ethanol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1076 64-17-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alcohol
  • ethanol
  • ethyl alcohol
  • grain alcohol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
  • Molecular weight: 46.07
  • Formula: C2H6O
  • CLOGP: -0.24
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: 1.10
  • ROTB: 0

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2170.63 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 17, 1946 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 8405.24 19.13 3086 27917 135115 53182948
Toxicity to various agents 4747.35 19.13 2364 28639 217234 53100829
Drug abuse 2744.90 19.13 1126 29877 64400 53253663
Cardio-respiratory arrest 1694.09 19.13 777 30226 57981 53260082
Intentional overdose 1525.53 19.13 754 30249 66451 53251612
Respiratory arrest 1145.56 19.13 500 30503 33040 53285023
Overdose 1095.83 19.13 715 30288 107021 53211042
Cardiac arrest 879.96 19.13 592 30411 93075 53224988
Suicide attempt 873.53 19.13 496 30507 57672 53260391
Poisoning 835.02 19.13 311 30692 13539 53304524
Intentional product misuse 735.45 19.13 419 30584 48973 53269090
Death 589.93 19.13 869 30134 356363 52961700
Alcohol interaction 537.69 19.13 139 30864 1718 53316345
Drug hypersensitivity 521.31 19.13 702 30301 264540 53053523
Alcohol poisoning 445.90 19.13 120 30883 1749 53316314
Alcohol use 443.69 19.13 122 30881 1936 53316127
Exposure via ingestion 339.02 19.13 110 30893 3145 53314918
Alcohol abuse 265.74 19.13 82 30921 1982 53316081
Coma 252.53 19.13 240 30763 61543 53256520
Suspected suicide 230.24 19.13 89 30914 4279 53313784
Poisoning deliberate 188.72 19.13 95 30908 8618 53309445
Somnolence 176.96 19.13 335 30668 167399 53150664
Blood alcohol increased 165.20 19.13 43 30960 546 53317517
Diarrhoea 160.71 19.13 82 30921 625464 52692599
Drug ineffective 126.68 19.13 175 30828 817070 52500993
Mydriasis 119.04 19.13 77 30926 11249 53306814
Methaemoglobinaemia 118.69 19.13 46 30957 2226 53315837
Fatigue 117.62 19.13 152 30851 730354 52587709
Headache 117.28 19.13 85 30918 536736 52781327
Pneumonia 111.03 19.13 49 30954 407120 52910943
Pain 108.06 19.13 110 30893 588288 52729775
Substance abuse 97.31 19.13 49 30954 4445 53313618
Intentional self-injury 95.25 19.13 94 30909 25190 53292873
Asthenia 94.17 19.13 41 30962 343549 52974514
Dyspnoea 93.14 19.13 123 30880 586109 52731954
Nausea 91.12 19.13 190 30813 755901 52562162
Alcoholism 88.31 19.13 37 30966 2194 53315869
Loss of consciousness 86.16 19.13 199 30804 114013 53204050
Off label use 85.76 19.13 89 30914 472123 52845940
Agitation 83.74 19.13 134 30869 58492 53259571
Anaemia 79.05 19.13 31 30972 276687 53041376
Cough 78.09 19.13 26 30977 256867 53061196
Rheumatoid arthritis 72.25 19.13 47 30956 314484 53003579
Drug abuser 70.09 19.13 35 30968 3118 53314945
Pyrexia 69.81 19.13 79 30924 403114 52914949
Metabolic acidosis 67.93 19.13 102 30901 42140 53275923
Product dose omission issue 66.44 19.13 15 30988 191605 53126458
Accidental death 65.64 19.13 28 30975 1736 53316327
Drug dependence 64.98 19.13 71 30932 21401 53296662
Tachycardia 64.14 19.13 172 30831 108040 53210023
Back pain 64.04 19.13 28 30975 234219 53083844
Rash 63.48 19.13 101 30902 446090 52871973
Malaise 63.06 19.13 69 30934 357548 52960515
Unresponsive to stimuli 62.94 19.13 87 30916 33339 53284724
Liver injury 61.59 19.13 70 30933 22033 53296030
Depressed level of consciousness 61.35 19.13 112 30891 54316 53263747
Urinary tract infection 59.05 19.13 33 30970 239870 53078193
Aggression 58.34 19.13 70 30933 23333 53294730
Postmortem blood drug level abnormal 57.08 19.13 16 30987 273 53317790
Neutropenia 56.10 19.13 12 30991 159173 53158890
Victim of sexual abuse 55.17 19.13 18 30985 523 53317540
Drug use disorder 55.13 19.13 30 30973 3189 53314874
Electrocardiogram QT prolonged 54.85 19.13 109 30894 56294 53261769
Exposure to toxic agent 54.36 19.13 25 30978 1855 53316208
Hepatic failure 54.09 19.13 84 30919 35722 53282341
Dizziness 53.15 19.13 84 30919 372175 52945888
Electrocardiogram QRS complex prolonged 52.98 19.13 36 30967 5706 53312357
Drug withdrawal syndrome 52.85 19.13 73 30930 27949 53290114
Gastrointestinal toxicity 51.58 19.13 33 30970 4729 53313334
Decreased appetite 48.14 19.13 33 30970 214941 53103122
Weight decreased 47.58 19.13 40 30963 234908 53083155
Bronchitis 47.26 19.13 5 30998 111894 53206169
Seizure 47.25 19.13 174 30829 129335 53188728
Constipation 46.40 19.13 29 30974 198383 53119680
Suicidal ideation 46.21 19.13 106 30897 60405 53257658
Arthralgia 45.91 19.13 119 30884 439664 52878399
Disease progression 44.50 19.13 4 30999 101916 53216147
Pain in extremity 43.89 19.13 61 30942 284989 53033074
Cerebrovascular accident 43.65 19.13 5 30998 105169 53212894
Pulmonary toxicity 43.20 19.13 31 30972 5360 53312703
White blood cell count decreased 42.61 19.13 10 30993 124465 53193598
Blood ethanol increased 42.59 19.13 10 30993 80 53317983
Myocarditis 42.58 19.13 37 30966 8431 53309632
Sepsis 42.43 19.13 16 30987 146413 53171650
Cardiac failure congestive 42.28 19.13 3 31000 92754 53225309
Postoperative wound infection 41.65 19.13 38 30965 9228 53308835
Febrile neutropenia 41.12 19.13 6 30997 104930 53213133
Respiratory depression 39.89 19.13 43 30960 12763 53305300
Sinus tachycardia 39.43 19.13 58 30945 23514 53294549
Somnambulism 38.63 19.13 29 30974 5373 53312690
Fall 38.14 19.13 96 30907 358344 52959719
Hepatotoxicity 37.44 19.13 62 30941 27818 53290245
Chest pain 36.54 19.13 34 30969 190151 53127912
Asphyxia 36.35 19.13 29 30974 5872 53312191
Influenza 36.13 19.13 6 30997 95373 53222690
Homicide 35.95 19.13 12 30991 375 53317688
Thrombocytopenia 35.69 19.13 18 30985 138709 53179354
Haemoglobin decreased 35.05 19.13 18 30985 137289 53180774
Pruritus 35.03 19.13 74 30929 293758 53024305
Abdominal pain 34.38 19.13 60 30943 255843 53062220
Pancytopenia 33.82 19.13 6 30997 90922 53227141
Accidental overdose 33.29 19.13 51 30952 21428 53296635
Aspiration 33.06 19.13 35 30968 10175 53307888
Condition aggravated 32.83 19.13 78 30925 297056 53021007
Housebound 32.78 19.13 10 30993 232 53317831
Drug screen positive 32.72 19.13 23 30980 3849 53314214
Pulmonary embolism 32.33 19.13 13 30990 114429 53203634
Blood pressure increased 32.18 19.13 21 30982 140458 53177605
Arthritis 31.96 19.13 6 30997 87292 53230771
Dehydration 31.30 19.13 31 30972 168379 53149684
Weight increased 31.24 19.13 44 30959 204523 53113540
Muscular weakness 31.03 19.13 10 30993 100982 53217081
Acute hepatic failure 30.69 19.13 43 30960 16677 53301386
Neuropathy peripheral 30.35 19.13 11 30992 103176 53214887
Injection site pain 30.25 19.13 14 30989 113377 53204686
Chemical submission 29.96 19.13 9 30994 198 53317865
Platelet count decreased 29.38 19.13 13 30990 108086 53209977
Disinhibition 29.28 19.13 13 30990 888 53317175
Iodine allergy 29.24 19.13 12 30991 675 53317388
Sinusitis 29.12 19.13 33 30970 168531 53149532
Erythema 29.05 19.13 29 30974 156940 53161123
Sopor 28.46 19.13 47 30956 21037 53297026
Mobility decreased 28.44 19.13 5 30998 76266 53241797
Protein C increased 28.14 19.13 8 30995 144 53317919
Environmental exposure 27.65 19.13 7 30996 79 53317984
Victim of chemical submission 27.64 19.13 9 30994 260 53317803
Loss of personal independence in daily activities 27.33 19.13 4 30999 69811 53248252
Herpes zoster 27.28 19.13 5 30998 74014 53244049
Abdominal pain upper 27.18 19.13 34 30969 166257 53151806
Brain oedema 26.59 19.13 36 30967 13522 53304541
Migraine 26.47 19.13 7 30996 80410 53237653
Alopecia 26.36 19.13 61 30942 234522 53083541
Malignant neoplasm progression 26.01 19.13 5 30998 71536 53246527
Oedema peripheral 25.80 19.13 37 30966 170750 53147313
Gastrooesophageal reflux disease 25.72 19.13 8 30995 82655 53235408
Asthma 25.35 19.13 16 30987 108956 53209107
Injection site erythema 24.91 19.13 7 30996 77242 53240821
Medication error 24.82 19.13 61 30942 36304 53281759
Incorrect route of product administration 24.78 19.13 42 30961 19202 53298861
Miosis 24.46 19.13 25 30978 6977 53311086
Induced abortion failed 23.85 19.13 8 30995 254 53317809
Alcohol withdrawal syndrome 23.79 19.13 11 30992 826 53317237
Abdominal discomfort 23.64 19.13 59 30944 221003 53097060
Osteoarthritis 23.46 19.13 6 30997 70480 53247583
Brain death 23.42 19.13 17 30986 2991 53315072
Septic shock 23.37 19.13 4 30999 62225 53255838
Oropharyngeal pain 23.33 19.13 9 30994 81259 53236804
Areflexia 23.28 19.13 17 30986 3019 53315044
Ventricular tachycardia 23.18 19.13 39 30964 17723 53300340
Blood pH decreased 23.11 19.13 16 30987 2614 53315449
Leukopenia 23.06 19.13 7 30996 73456 53244607
Toxicologic test abnormal 22.91 19.13 10 30993 656 53317407
Amnesia 22.90 19.13 68 30935 45220 53272843
Shock 22.82 19.13 45 30958 23094 53294969
Productive cough 22.79 19.13 3 31000 56726 53261337
Visceral congestion 22.40 19.13 8 30995 307 53317756
Substance dependence 22.38 19.13 7 30996 177 53317886
C-reactive protein increased 22.17 19.13 6 30997 67880 53250183
Abnormal behaviour 22.14 19.13 43 30960 21823 53296240
Swelling 22.03 19.13 49 30954 191056 53127007
Hypotension 21.99 19.13 235 30768 253841 53064222
Alcoholic 21.88 19.13 5 30998 35 53318028
Pulmonary congestion 21.78 19.13 36 30967 16120 53301943
Muscle spasms 21.57 19.13 28 30975 134767 53183296
Interstitial lung disease 21.51 19.13 4 30999 58618 53259445
Drug interaction 21.43 19.13 208 30795 219121 53098942
Product administration error 21.39 19.13 42 30961 21489 53296574
Euphoric mood 21.19 19.13 19 30984 4510 53313553
Upper respiratory tract infection 20.95 19.13 7 30996 69090 53248973
Analgesic drug level increased 20.81 19.13 13 30990 1787 53316276
Acute kidney injury 20.54 19.13 77 30926 253791 53064272
Infusion related reaction 20.53 19.13 37 30966 155920 53162143
Drug level increased 20.48 19.13 40 30963 20381 53297682
Hospitalisation 20.16 19.13 8 30995 71004 53247059
Peripheral swelling 19.78 19.13 58 30945 206050 53112013
Cyanosis 19.70 19.13 35 30968 16604 53301459
Ventricular fibrillation 19.45 19.13 29 30974 11896 53306167
Blood methanol increased 19.35 19.13 3 31000 0 53318063

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 6857.18 21.42 2619 27932 77624 32405351
Completed suicide 6103.07 21.42 2506 28045 90011 32392964
Toxicity to various agents 5093.90 21.42 2703 27848 175338 32307637
Cardio-respiratory arrest 1384.54 21.42 780 29771 55209 32427766
Intentional product misuse 1181.10 21.42 606 29945 35445 32447530
Intentional overdose 1152.18 21.42 625 29926 40976 32441999
Poisoning 954.00 21.42 368 30183 10790 32472185
Respiratory arrest 929.06 21.42 480 30071 28428 32454547
Overdose 921.20 21.42 714 29837 86363 32396612
Alcohol abuse 703.64 21.42 232 30319 4240 32478735
Suicide attempt 606.86 21.42 402 30149 37842 32445133
Cardiac arrest 569.10 21.42 569 29982 96207 32386768
Alcohol interaction 514.84 21.42 156 30395 2133 32480842
Alcohol poisoning 474.99 21.42 160 30391 3129 32479846
Exposure via ingestion 463.88 21.42 145 30406 2212 32480763
Substance abuse 406.96 21.42 176 30375 6931 32476044
Death 354.60 21.42 966 29585 381551 32101424
Drug dependence 348.46 21.42 237 30314 23247 32459728
Alcohol use 333.73 21.42 124 30427 3259 32479716
Coma 263.50 21.42 258 30293 42354 32440621
Suspected suicide 255.40 21.42 99 30452 2929 32480046
Poisoning deliberate 230.99 21.42 115 30436 6260 32476715
Asphyxia 229.84 21.42 110 30441 5490 32477485
Blood alcohol increased 208.70 21.42 60 30491 674 32482301
Pneumonia 188.31 21.42 51 30500 355201 32127774
Diarrhoea 183.08 21.42 58 30493 364744 32118231
Aggression 181.68 21.42 204 30347 39185 32443790
Pyrexia 158.43 21.42 52 30499 319916 32163059
Anaemia 156.16 21.42 15 30536 223609 32259366
Drug ineffective 150.93 21.42 87 30464 383390 32099585
Accidental death 148.21 21.42 61 30490 2116 32480859
Dyspnoea 142.62 21.42 82 30469 361963 32121012
Respiratory depression 140.38 21.42 109 30442 13102 32469873
Fatigue 128.99 21.42 86 30465 350615 32132360
Accidental overdose 117.36 21.42 116 30435 19223 32463752
Rash 108.87 21.42 31 30520 209302 32273673
Incorrect route of product administration 103.89 21.42 87 30464 11639 32471336
Neutropenia 100.57 21.42 9 30542 142166 32340809
Intentional self-injury 98.81 21.42 91 30460 13809 32469166
Off label use 92.68 21.42 91 30460 306229 32176746
Alcohol withdrawal syndrome 92.15 21.42 39 30512 1452 32481523
Drug withdrawal syndrome 91.87 21.42 104 30447 20127 32462848
Cough 90.04 21.42 12 30539 138805 32344170
Sepsis 89.32 21.42 20 30531 158814 32324161
Drug abuser 86.25 21.42 52 30499 4132 32478843
Nausea 83.23 21.42 108 30443 320741 32162234
Drug screen positive 83.04 21.42 51 30500 4190 32478785
Asthenia 79.85 21.42 63 30488 235881 32247094
Arthralgia 78.96 21.42 21 30530 148427 32334548
Miosis 77.97 21.42 65 30486 8639 32474336
Febrile neutropenia 75.96 21.42 11 30540 119555 32363420
Alcoholism 75.20 21.42 45 30506 3527 32479448
Intentional product use issue 68.94 21.42 134 30417 42077 32440898
Pain in extremity 68.80 21.42 14 30537 118887 32364088
Suicidal ideation 67.27 21.42 125 30426 37958 32445017
Agitation 66.23 21.42 158 30393 57078 32425897
Product dose omission issue 66.17 21.42 9 30542 102566 32380409
Back pain 62.36 21.42 14 30537 111039 32371936
Pruritus 61.60 21.42 22 30529 128680 32354295
Decreased appetite 60.86 21.42 38 30513 160775 32322200
Alcohol intolerance 60.31 21.42 20 30531 371 32482604
Pancytopenia 58.85 21.42 8 30543 91227 32391748
White blood cell count decreased 58.82 21.42 8 30543 91190 32391785
Malignant neoplasm progression 58.18 21.42 4 30547 78492 32404483
Haemoglobin decreased 58.05 21.42 20 30531 119651 32363324
Sopor 57.81 21.42 63 30488 11686 32471289
Platelet count decreased 57.61 21.42 18 30533 114573 32368402
Mydriasis 57.45 21.42 48 30503 6398 32476577
Pain 57.43 21.42 55 30496 187501 32295474
Road traffic accident 57.25 21.42 76 30475 17305 32465670
Medication error 57.19 21.42 87 30464 22448 32460527
Drug use disorder 57.12 21.42 38 30513 3583 32479392
Oedema peripheral 55.46 21.42 19 30532 114072 32368903
Depressed level of consciousness 55.28 21.42 120 30431 40727 32442248
Environmental exposure 55.18 21.42 17 30534 246 32482729
Dizziness 54.81 21.42 70 30481 209548 32273427
Unresponsive to stimuli 54.33 21.42 95 30456 27514 32455461
Infection 53.31 21.42 8 30543 84707 32398268
Condition aggravated 53.30 21.42 41 30510 155620 32327355
Withdrawal syndrome 52.80 21.42 61 30490 12061 32470914
Thrombocytopenia 52.14 21.42 38 30513 148261 32334714
Cerebrovascular accident 50.26 21.42 10 30541 86310 32396665
Cardiac failure 48.64 21.42 13 30538 91660 32391315
Blood ethanol increased 47.53 21.42 17 30534 399 32482576
Renal impairment 47.02 21.42 14 30537 91958 32391017
Cardiac failure congestive 47.02 21.42 11 30540 84841 32398134
Ex-drug abuser 46.67 21.42 13 30538 129 32482846
Atrial fibrillation 46.35 21.42 26 30525 116678 32366297
Shock 46.18 21.42 82 30469 24032 32458943
Dehydration 45.38 21.42 33 30518 128925 32354050
Headache 44.87 21.42 72 30479 196125 32286850
Chest pain 44.69 21.42 31 30520 124106 32358869
Metabolic acidosis 44.55 21.42 110 30441 40589 32442386
Abdominal pain 43.29 21.42 46 30505 149483 32333492
Myocardial infarction 43.14 21.42 33 30518 125643 32357332
Physical assault 42.89 21.42 21 30530 1101 32481874
Somnolence 42.79 21.42 202 30349 103595 32379380
Homicide 42.63 21.42 20 30531 953 32482022
Nasopharyngitis 42.57 21.42 5 30546 63782 32419193
Methaemoglobinaemia 42.54 21.42 29 30522 2847 32480128
General physical health deterioration 42.53 21.42 28 30523 115231 32367744
Weight decreased 42.07 21.42 56 30495 164762 32318213
Neuropathy peripheral 40.68 21.42 11 30540 76971 32406004
Pulmonary embolism 40.52 21.42 14 30537 83645 32399330
Pleural effusion 40.42 21.42 12 30539 78980 32403995
Amnesia 40.28 21.42 79 30472 24957 32458018
Deep vein thrombosis 40.11 21.42 6 30545 63707 32419268
Urinary tract infection 39.48 21.42 13 30538 80058 32402917
Constipation 38.71 21.42 37 30514 126336 32356639
Malaise 37.73 21.42 68 30483 177070 32305905
Self-medication 37.59 21.42 25 30526 2356 32480619
Peripheral swelling 37.58 21.42 9 30542 68336 32414639
Joint swelling 37.29 21.42 3 30548 51732 32431243
Muscular weakness 37.25 21.42 9 30542 67920 32415055
Cluster headache 36.83 21.42 15 30536 506 32482469
Drug intolerance 35.97 21.42 3 30548 50232 32432743
Acute kidney injury 35.30 21.42 149 30402 293319 32189656
Erythema 35.23 21.42 17 30534 83088 32399887
Suicidal behaviour 34.83 21.42 20 30531 1451 32481524
Chronic obstructive pulmonary disease 34.66 21.42 3 30548 48750 32434225
Urticaria 34.50 21.42 7 30544 59607 32423368
Hepatic fibrosis 34.45 21.42 28 30523 3590 32479385
Septic shock 34.36 21.42 11 30540 68978 32413997
Loss of consciousness 34.09 21.42 161 30390 82546 32400429
Gun shot wound 34.07 21.42 18 30533 1108 32481867
Abnormal behaviour 33.81 21.42 76 30475 26390 32456585
Tachycardia 33.37 21.42 155 30396 78933 32404042
Weight increased 32.69 21.42 19 30532 83644 32399331
Dysarthria 32.45 21.42 86 30465 33115 32449860
Toxicologic test abnormal 32.42 21.42 14 30537 548 32482427
Dysphagia 32.07 21.42 9 30542 61467 32421508
Infusion related reaction 31.90 21.42 3 30548 45596 32437379
Exposure to toxic agent 31.82 21.42 17 30534 1071 32481904
Impaired driving ability 31.67 21.42 23 30528 2496 32480479
Chills 31.56 21.42 17 30534 78067 32404908
Pulmonary oedema 31.12 21.42 105 30446 46162 32436813
Renal failure 31.04 21.42 49 30502 134429 32348546
Myalgia 30.96 21.42 19 30532 81211 32401764
Thrombosis 29.52 21.42 4 30547 45750 32437225
Leukopenia 29.21 21.42 10 30541 60112 32422863
Prescription drug used without a prescription 28.81 21.42 17 30534 1298 32481677
Product use in unapproved indication 28.53 21.42 24 30527 87180 32395795
Foetal alcohol syndrome 28.20 21.42 9 30542 147 32482828
Influenza 27.47 21.42 5 30546 46009 32436966
Stomatitis 27.22 21.42 3 30548 40226 32442749
C-reactive protein increased 27.11 21.42 6 30545 48096 32434879
Exposure via inhalation 27.04 21.42 7 30544 51 32482924
Chest discomfort 26.87 21.42 7 30544 50223 32432752
Drug interaction 26.38 21.42 317 30234 217868 32265107
Haematochezia 26.34 21.42 3 30548 39205 32443770
Acidosis 26.28 21.42 41 30510 10805 32472170
Dyspnoea exertional 26.12 21.42 3 30548 38958 32444017
Hospitalisation 25.86 21.42 7 30544 48964 32434011
Accident 25.50 21.42 25 30526 4097 32478878
Bradypnoea 25.29 21.42 20 30531 2466 32480509
Drug hypersensitivity 24.71 21.42 135 30416 73265 32409710
Chronic kidney disease 24.62 21.42 4 30547 39971 32443004
Abdominal distension 24.12 21.42 9 30542 51286 32431689
Psoriasis 23.60 21.42 7 30544 46116 32436859
Haematuria 23.57 21.42 8 30543 48353 32434622
Pupil fixed 23.50 21.42 17 30534 1834 32481141
Acute hepatic failure 23.42 21.42 43 30508 12926 32470049
Cellulitis 23.31 21.42 9 30542 50221 32432754
Drug diversion 23.30 21.42 13 30538 892 32482083
Blood creatinine increased 23.16 21.42 34 30517 96098 32386877
Hypersensitivity 22.72 21.42 13 30538 57745 32425230
Fall 22.70 21.42 101 30450 196100 32286875
Sensorimotor disorder 22.61 21.42 10 30541 415 32482560
Legal problem 22.56 21.42 8 30543 183 32482792
Brain oedema 22.19 21.42 42 30509 12918 32470057
Alcoholic liver disease 22.09 21.42 11 30540 598 32482377
Sinus tachycardia 21.94 21.42 48 30503 16366 32466609
Musculoskeletal stiffness 21.92 21.42 5 30546 39259 32443716
Bronchitis 21.79 21.42 6 30545 41501 32441474
Drug level increased 21.67 21.42 54 30497 20026 32462949
Electrocardiogram QRS complex prolonged 21.58 21.42 24 30527 4550 32478425
Haemoptysis 21.46 21.42 3 30548 33522 32449453

Pharmacologic Action:

SourceCodeDescription
ATC D08AX08 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Other antiseptics and disinfectants
ATC V03AB16 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
ATC V03AZ01 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Nerve depressants
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D012997 Solvents
CHEBI has role CHEBI:35488 CNS depressants
CHEBI has role CHEBI:48218 local microbicides
CHEBI has role CHEBI:48219 Desinfektionsmittel
CHEBI has role CHEBI:48354 polar solvents
CHEBI has role CHEBI:50905 teratogen
CHEBI has role CHEBI:50910 agente neurotoxico
CHEBI has role CHEBI:60643 N-methyl-D-aspartate receptor antagonists
CHEBI has role CHEBI:64018 protein kinase C agonists
CHEBI has role CHEBI:75771 Mus musculus metabolite
CHEBI has role CHEBI:75772 bakers yeast metabolite
CHEBI has role CHEBI:76971 E.coli metabolites
CHEBI has role CHEBI:77746 H. sapiens metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Antiseptic preparation indication 261276004

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
99% (1ML) ABLYSINOL BELCHER N207987 June 21, 2018 RX SOLUTION INTRA-ARTERIAL June 21, 2025 INDICATED TO INDUCE CONTROLLED CARDIAC SEPTAL INFRACTION TO IMPROVE EXERCISE CAPACITY IN ADULTS WITH SYMPTOMATIC HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY WHO ARE NOT CANDIDATES FOR SURGICAL MYECTOMY
99% (5ML) ABLYSINOL BELCHER N207987 June 21, 2018 RX SOLUTION INTRA-ARTERIAL June 21, 2025 INDICATED TO INDUCE CONTROLLED CARDIAC SEPTAL INFRACTION TO IMPROVE EXERCISE CAPACITY IN ADULTS WITH SYMPTOMATIC HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY WHO ARE NOT CANDIDATES FOR SURGICAL MYECTOMY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glutamate receptor ionotropic, NMDA 3A Ion channel WOMBAT-PK
Glycine receptor subunit alpha-1 Ion channel WOMBAT-PK
Glycine receptor subunit alpha-2 Ion channel WOMBAT-PK
GABA A receptor alpha-4/beta-2/delta Ion channel WOMBAT-PK

External reference:

IDSource
4017736 VUID
N0000146104 NUI
D06542 KEGG_DRUG
4017424 VANDF
4017736 VANDF
C0001962 UMLSCUI
CHEBI:16236 CHEBI
EOH PDB_CHEM_ID
CHEMBL545 ChEMBL_ID
702 PUBCHEM_CID
DB00898 DRUGBANK_ID
D000431 MESH_DESCRIPTOR_UI
2299 IUPHAR_LIGAND_ID
3K9958V90M UNII
448 RXNORM
10010 MMSL
4693 MMSL
9888 MMSL
d03162 MMSL
001539 NDDF
002464 NDDF
333164008 SNOMEDCT_US
398624005 SNOMEDCT_US
419442005 SNOMEDCT_US
53041004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TRISEPTINHAND AND BODY ANTISEPTIC HUMAN OTC DRUG LABEL 1 0064-1050 LOTION 0.70 mL TOPICAL OTC monograph not final 9 sections
SURGICEPT Waterless, Surgical Handscrub and Healthcare Personnel Handwash HUMAN OTC DRUG LABEL 1 0064-1080 SOLUTION 0.75 mL TOPICAL OTC monograph not final 10 sections
hand sanitizer HUMAN OTC DRUG LABEL 1 0113-7077 GEL 70 mL TOPICAL OTC monograph not final 12 sections
Humphreys Alcoholado Maravilla HUMAN OTC DRUG LABEL 1 0219-2020 LIQUID 70 mL TOPICAL OTC MONOGRAPH NOT FINAL 13 sections
Nozin Nasal Sanitizer HUMAN OTC DRUG LABEL 1 0295-9025 LIQUID 62 mL TOPICAL OTC monograph not final 9 sections
Keri Clinical Care Hand Sanitizing Gel - HEALTHCARE HUMAN OTC DRUG LABEL 1 0316-0214 GEL 0.70 mL TOPICAL OTC monograph not final 11 sections
Keri Clinical Care Hand Sanitizing Gel HUMAN OTC DRUG LABEL 1 0316-0292 GEL 0.70 mL TOPICAL OTC monograph not final 11 sections
SeptoSan Hand Sanitizer HUMAN OTC DRUG LABEL 1 0362-6000 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
SeptoSan Hand Sanitizer HUMAN OTC DRUG LABEL 1 0362-6001 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
SeptoSan Hand Sanitizer HUMAN OTC DRUG LABEL 1 0362-6002 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
Alcohol HUMAN OTC DRUG LABEL 1 0363-0046 LIQUID 62 mg TOPICAL OTC monograph not final 12 sections
Iodine HUMAN OTC DRUG LABEL 3 0363-0088 LIQUID 470 mg TOPICAL OTC monograph not final 12 sections
Advanced Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0370 GEL 70 mL TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0469 GEL 545 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0596 GEL 567 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0643 GEL 558 mg TOPICAL OTC monograph not final 11 sections
Crisp Apple Hand Sani HUMAN OTC DRUG LABEL 1 0363-0663 LIQUID 585 g TOPICAL OTC monograph not final 13 sections
Ethyl Rubbing Alcohol HUMAN OTC DRUG LABEL 1 0363-0876 LIQUID 610 mg TOPICAL OTC monograph not final 13 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0890 GEL 567 mg TOPICAL OTC monograph not final 11 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0898 GEL 567 mg TOPICAL OTC monograph not final 11 sections
Advanced Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0952 GEL 700 mg TOPICAL OTC monograph not final 12 sections
WALGREENS ADVANCED HAND SANITIZER WITH FRESH SCENT HUMAN OTC DRUG LABEL 1 0363-0967 AEROSOL, SPRAY 70 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0968 LOTION 558 mg TOPICAL OTC monograph not final 13 sections
Walgreens Advanced Hand Sanitizer Citrus Scent HUMAN OTC DRUG LABEL 1 0363-0969 AEROSOL, SPRAY 70 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0984 GEL 567 mg TOPICAL OTC monograph not final 11 sections
A Little Something Eucalyptus Mist Hand Sanitier HUMAN OTC DRUG LABEL 1 0363-1050 LIQUID 700 mg TOPICAL OTC monograph not final 1 sections
A Little Something Eucalyptus Mist Hand Sanitier HUMAN OTC DRUG LABEL 1 0363-1050 LIQUID 700 mg TOPICAL OTC monograph not final 1 sections
A Little Something Prosecco Bubbles Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-1051 LIQUID 700 mg TOPICAL OTC monograph not final 1 sections
A Little Something Prosecco Bubbles Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-1051 LIQUID 700 mg TOPICAL OTC monograph not final 1 sections
WalgreensHand Sanitizer Aloe Vitamin E HUMAN OTC DRUG LABEL 1 0363-1305 LIQUID 62 mL TOPICAL OTC monograph not final 11 sections