ethanol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1076 64-17-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alcohol
  • ethanol
  • ethyl alcohol
  • grain alcohol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
  • Molecular weight: 46.07
  • Formula: C2H6O
  • CLOGP: -0.24
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: 1.10
  • ROTB: 0

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2170.63 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Jan. 17, 1946 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 7284.14 22.02 4085 166445 140973 90316944
Toxicity to various agents 3202.09 22.02 3286 167244 284560 90173357
Drug abuse 2611.23 22.02 1732 168798 80615 90377302
Cardio-respiratory arrest 1292.10 22.02 1019 169511 62121 90395796
Respiratory arrest 745.15 22.02 567 169963 32744 90425173
Intentional overdose 713.13 22.02 881 169649 92953 90364964
Irritable bowel syndrome 617.35 22.02 1267 169263 206181 90251736
Folliculitis 600.91 22.02 1242 169288 203111 90254806
Poisoning 590.47 22.02 364 170166 14853 90443064
Injury 551.73 22.02 1175 169355 196174 90261743
Muscle injury 548.13 22.02 1098 169432 175556 90282361
Helicobacter infection 540.39 22.02 1267 169263 225583 90232334
Ill-defined disorder 537.95 22.02 1119 169411 183772 90274145
Alcohol interaction 527.24 22.02 176 170354 1578 90456339
Cough 508.70 22.02 52 170478 368910 90089007
Drug ineffective 504.47 22.02 1170 169360 1383128 89074789
Impaired healing 502.14 22.02 1256 169274 232943 90224974
Anaemia 490.87 22.02 48 170482 352754 90105163
Rheumatic fever 469.26 22.02 947 169583 152174 90305743
Duodenal ulcer perforation 457.88 22.02 1171 169359 220117 90237800
Type 2 diabetes mellitus 423 22.02 1078 169452 202166 90255751
Joint range of motion decreased 420.46 22.02 843 169687 134800 90323117
Suicide attempt 414.93 22.02 605 169925 74794 90383123
Sleep disorder 414.88 22.02 1053 169477 196977 90260940
Alcohol poisoning 402.05 22.02 147 170383 1765 90456152
Overdose 398.60 22.02 902 169628 156807 90301110
Urinary tract infection 391.79 22.02 55 170475 305577 90152340
Pericarditis 391.01 22.02 1257 169273 268894 90189023
Liver injury 390.05 22.02 938 169592 169629 90288288
Cardiac arrest 386.65 22.02 702 169828 104233 90353684
Constipation 385.12 22.02 40 170490 280355 90177562
Suspected suicide 384.29 22.02 234 170296 9334 90448583
Sleep disorder due to general medical condition, insomnia type 362.56 22.02 769 169761 127925 90329992
Neutropenia 361.96 22.02 14 170516 224890 90233027
Swollen joint count increased 358.88 22.02 703 169827 110503 90347414
Hand deformity 357.88 22.02 1298 169232 295064 90162853
Product dose omission issue 352.34 22.02 62 170468 291625 90166292
Hypercholesterolaemia 335.55 22.02 646 169884 100246 90357671
Adjustment disorder with depressed mood 335.15 22.02 471 170059 56282 90401635
Intentional product misuse 332.05 22.02 601 169929 89003 90368914
Back pain 329.81 22.02 94 170436 317081 90140836
Dislocation of vertebra 328.30 22.02 463 170067 55505 90402412
Lupus vulgaris 311.85 22.02 404 170126 44655 90413262
Lip dry 308.66 22.02 624 169906 100331 90357586
Glossodynia 307.96 22.02 1310 169220 320469 90137448
Facet joint syndrome 306.61 22.02 613 169917 97776 90360141
Fall 302.33 22.02 277 170253 481533 89976384
Blister 301.96 22.02 1110 169420 253888 90204029
Exposure to toxic agent 300.00 22.02 187 170343 7780 90450137
Wound 299.67 22.02 1246 169284 301734 90156183
Lower respiratory tract infection 296.71 22.02 1091 169439 249568 90208349
Fibromyalgia 296.66 22.02 958 169572 205311 90252606
Pemphigus 293.16 22.02 1305 169225 325559 90132358
Anti-cyclic citrullinated peptide antibody positive 290.77 22.02 1042 169488 235391 90222526
Amnesia 290.24 22.02 635 169895 107870 90350047
Grip strength decreased 288.73 22.02 577 169953 91999 90365918
Psoriatic arthropathy 288.24 22.02 1015 169515 227320 90230597
Road traffic accident 286.91 22.02 629 169901 106997 90350920
Acute kidney injury 285.02 22.02 123 170407 320264 90137653
Rheumatoid factor positive 283.77 22.02 837 169693 170813 90287104
Wound infection 279.28 22.02 618 169912 105784 90352133
Victim of crime 276.09 22.02 91 170439 781 90457136
Deep vein thrombosis postoperative 266.22 22.02 478 170052 70331 90387586
Diarrhoea 263.51 22.02 898 169632 938292 89519625
Erythema 263.50 22.02 55 170475 229191 90228726
Febrile neutropenia 261.26 22.02 8 170522 158341 90299576
Nausea 243.96 22.02 1169 169361 1109147 89348770
Stomatitis 243.37 22.02 1093 169437 273605 90184312
C-reactive protein abnormal 242.51 22.02 654 169876 126775 90331142
Dehydration 242.14 22.02 38 170492 194409 90263508
Disease progression 241.35 22.02 13 170517 156602 90301315
Exposure via ingestion 240.86 22.02 112 170418 2555 90455362
Breast cancer stage III 240.50 22.02 507 170023 83940 90373977
White blood cell count decreased 239.59 22.02 20 170510 167089 90290828
Blood cholesterol increased 233.25 22.02 890 169640 207122 90250795
X-ray abnormal 231.92 22.02 352 170178 45072 90412845
Blood pressure increased 231.46 22.02 45 170485 197172 90260745
Alcohol use 229.47 22.02 95 170435 1622 90456295
Haemoglobin decreased 225.15 22.02 22 170508 161934 90295983
Injection site pain 223.08 22.02 31 170499 173668 90284249
Pulmonary fibrosis 220.08 22.02 567 169963 106936 90350981
Sepsis 217.52 22.02 38 170492 179776 90278141
Lower limb fracture 213.24 22.02 485 170045 84528 90373389
Hepatic enzyme increased 211.14 22.02 1279 169251 359457 90098460
COVID-19 210.21 22.02 33 170497 168810 90289107
Discomfort 209.04 22.02 1045 169485 273290 90184627
Synovitis 209.01 22.02 1194 169336 328558 90129359
Gait inability 205.74 22.02 675 169855 145781 90312136
Off label use 204.55 22.02 1228 169302 1101024 89356893
Autoimmune disorder 203.89 22.02 448 170082 76296 90381621
Systemic lupus erythematosus 201.04 22.02 1266 169264 360630 90097287
Alcohol abuse 198.08 22.02 90 170440 1943 90455974
Confusional state 193.81 22.02 1317 169213 384888 90073029
Fatigue 192.06 22.02 1329 169201 1152694 89305223
Mobility decreased 188.80 22.02 952 169578 249782 90208135
Liver disorder 186.82 22.02 577 169953 120692 90337225
Retinitis 185.07 22.02 290 170240 38168 90419749
Platelet count decreased 184.24 22.02 21 170509 136948 90320969
Pulmonary embolism 183.87 22.02 17 170513 130803 90327114
Contusion 183.68 22.02 946 169584 250270 90207647
Anti-cyclic citrullinated peptide antibody 183.55 22.02 241 170289 26980 90430937
Influenza 183.25 22.02 23 170507 139241 90318676
Delirium 183.08 22.02 520 170010 103839 90354078
Feeling abnormal 182.37 22.02 45 170485 167190 90290727
Neuropathy peripheral 181.75 22.02 22 170508 136948 90320969
Pancytopenia 179.18 22.02 12 170518 120251 90337666
Porphyria acute 178.76 22.02 194 170336 17781 90440136
Peripheral venous disease 178.37 22.02 449 170081 83472 90374445
Walking aid user 178.22 22.02 273 170257 35233 90422684
Chills 175.62 22.02 21 170509 131960 90325957
Gastrointestinal disorder 175.59 22.02 949 169581 255738 90202179
Hyponatraemia 171.06 22.02 24 170506 133514 90324403
Malignant neoplasm progression 170.70 22.02 7 170523 106863 90351054
Substance use disorder 170.61 22.02 81 170449 1939 90455978
Wheezing 168.83 22.02 889 169641 237191 90220726
Myalgia 160.85 22.02 64 170466 175061 90282856
Bone erosion 158.74 22.02 325 170205 52696 90405221
Chest discomfort 157.29 22.02 34 170496 138331 90319586
Poisoning deliberate 157.13 22.02 174 170356 16312 90441605
Oedema 156.75 22.02 769 169761 199526 90258391
Prescribed overdose 155.48 22.02 470 170060 97155 90360762
Oropharyngeal pain 154.07 22.02 18 170512 115169 90342748
Lupus-like syndrome 151.69 22.02 304 170226 48542 90409375
Exostosis 151.23 22.02 319 170211 52815 90405102
Sciatica 150.25 22.02 476 170054 100906 90357011
Ulcer haemorrhage 148.79 22.02 214 170316 26107 90431810
Herpes zoster 148.52 22.02 7 170523 94637 90363280
Cerebrovascular accident 147.44 22.02 27 170503 123506 90334411
Obesity 145.20 22.02 483 170047 105024 90352893
Subcutaneous drug absorption impaired 144.96 22.02 152 170378 13393 90444524
Bursitis 143.13 22.02 558 169972 131096 90326821
Hepatic cirrhosis 139.21 22.02 343 170187 62910 90395007
Vision blurred 138.53 22.02 21 170509 110272 90347645
Drug use disorder 137.77 22.02 119 170411 8224 90449693
Onychomycosis 136.23 22.02 249 170281 37127 90420790
Laryngitis 135.60 22.02 297 170233 50456 90407461
Injection site erythema 135.27 22.02 14 170516 98488 90359429
Dyspepsia 134.35 22.02 731 169799 197429 90260488
Septic shock 132.79 22.02 6 170524 84154 90373763
Anaphylactic reaction 132.56 22.02 8 170522 87516 90370401
Dysphagia 130.90 22.02 26 170504 112252 90345665
Night sweats 130.54 22.02 534 169996 128232 90329685
Infusion related reaction 129.59 22.02 1275 169255 415505 90042412
Syncope 129.37 22.02 44 170486 132619 90325298
General physical health deterioration 128.84 22.02 1123 169407 353992 90103925
Rheumatoid arthritis 126.03 22.02 1136 169394 361478 90096439
General symptom 123.18 22.02 145 170385 14523 90443394
Cellulitis 122.83 22.02 14 170516 91323 90366594
Deep vein thrombosis 120.84 22.02 15 170515 91605 90366312
Blood alcohol increased 120.58 22.02 44 170486 525 90457392
Onychomadesis 120.43 22.02 267 170263 45731 90412186
Headache 120.39 22.02 1042 169488 861704 89596213
Chemical submission 119.85 22.02 43 170487 487 90457430
Infection 118.08 22.02 1119 169411 360975 90096942
Palpitations 117.54 22.02 55 170475 136673 90321244
Prescribed underdose 117.40 22.02 359 170171 74660 90383257
Asthenia 116.62 22.02 562 169968 533189 89924728
Interstitial lung disease 115.67 22.02 7 170523 76398 90381519
Hyperhidrosis 115.38 22.02 56 170474 136249 90321668
Rhinorrhoea 115.17 22.02 15 170515 88301 90369616
Memory impairment 114.97 22.02 699 169831 196545 90261372
Medication error 112.45 22.02 383 170147 84269 90373648
Epistaxis 112.12 22.02 14 170516 85111 90372806
Influenza like illness 111.88 22.02 11 170519 80600 90377317
Disability 111.77 22.02 241 170289 40504 90417413
Thrombocytopenia 111.65 22.02 137 170393 208588 90249329
Renal failure 110.62 22.02 54 170476 130953 90326964
Neutrophil count decreased 109.98 22.02 6 170524 71526 90386391
Tremor 109.71 22.02 77 170453 153096 90304821
Pustular psoriasis 109.50 22.02 154 170376 18402 90439515
Rash vesicular 108.83 22.02 152 170378 18045 90439872
Arthropathy 108.77 22.02 1110 169420 365132 90092785
Renal impairment 108.07 22.02 32 170498 105389 90352528
Cystitis 107.80 22.02 4 170526 66714 90391203
Inappropriate schedule of product administration 106.56 22.02 76 170454 149857 90308060
Urticaria 106.21 22.02 975 169555 311759 90146158
Balance disorder 106.05 22.02 26 170504 97054 90360863
Haematochezia 105.85 22.02 7 170523 70906 90387011
Atrial fibrillation 105.55 22.02 60 170470 133551 90324366
Cataract 105.05 22.02 8 170522 72084 90385833
Gastrointestinal haemorrhage 104.99 22.02 21 170509 90227 90367690
Myocardial infarction 103.58 22.02 35 170495 105937 90351980
Productive cough 103.15 22.02 12 170518 77051 90380866
Cardiac failure congestive 102.93 22.02 29 170501 98665 90359252
Intentional product use issue 102.33 22.02 729 169801 216163 90241754
Nasal congestion 102.23 22.02 17 170513 83397 90374520
Thrombosis 101.65 22.02 10 170520 73241 90384676
Hip arthroplasty 101.40 22.02 345 170185 75863 90382054
Colitis 101.25 22.02 8 170522 69934 90387983
Death 99.87 22.02 1304 169226 455247 90002670
Dry mouth 98.98 22.02 639 169891 183420 90274497
Swelling 98.92 22.02 1214 169316 417844 90040073
Lung disorder 98.26 22.02 548 169982 149335 90308582
Hypokalaemia 97.81 22.02 63 170467 131053 90326864
Grip strength 96.64 22.02 101 170429 8864 90449053
Respiratory failure 95.24 22.02 52 170478 118366 90339551
Maternal exposure timing unspecified 95.19 22.02 160 170370 22323 90435594
Substance abuse 95.18 22.02 80 170450 5326 90452591
Coma 94.18 22.02 326 170204 72306 90385611
Inflammation 94.18 22.02 617 169913 177975 90279942
Pneumonia 94.12 22.02 759 169771 637300 89820617
Dry skin 93.49 22.02 25 170505 88048 90369869
Joint dislocation 93.10 22.02 237 170293 44345 90413572
Dyspnoea exertional 92.54 22.02 13 170517 72275 90385642
Hypertrichosis 91.48 22.02 48 170482 1431 90456486
Pleural effusion 90.33 22.02 49 170481 111942 90345975
Hypoaesthesia 90.26 22.02 946 169584 313264 90144653
Diabetes mellitus 89.64 22.02 9 170521 64866 90393051
Blood pressure systolic increased 89.37 22.02 5 170525 58340 90399577
C-reactive protein 88.88 22.02 188 170342 31179 90426738
Blood glucose increased 88.76 22.02 34 170496 95212 90362705
Chronic obstructive pulmonary disease 88.38 22.02 16 170514 73813 90384104
Cardiac failure 88.18 22.02 48 170482 109448 90348469
Eye injury 87.71 22.02 106 170424 10914 90447003
Back disorder 87.45 22.02 166 170364 25465 90432452
Flushing 86.88 22.02 29 170501 88462 90369455
Osteoarthritis 86.65 22.02 648 169882 195082 90262835
Mydriasis 86.23 22.02 123 170407 14889 90443028
Hypersensitivity 86.16 22.02 1266 169264 453411 90004506
Heart rate increased 85.93 22.02 53 170477 112849 90345068
Breast cancer stage II 85.70 22.02 199 170331 35135 90422782
Pain 85.28 22.02 1341 169189 995000 89462917
Rash erythematous 85.03 22.02 11 170519 65093 90392824
Dysphonia 84.00 22.02 10 170520 63074 90394843
Blood creatinine increased 83.77 22.02 43 170487 101343 90356574
Injection site swelling 83.47 22.02 8 170522 59831 90398086
Incorrect dose administered 82.66 22.02 23 170507 78907 90379010
Burning sensation 82.20 22.02 11 170519 63441 90394476
Injection site bruising 81.64 22.02 4 170526 52303 90405614
Injection site pruritus 81.28 22.02 5 170525 53829 90404088
Insomnia 81.22 22.02 972 169558 332502 90125415
Foot deformity 81.08 22.02 272 170258 59379 90398538
Nasopharyngitis 80.87 22.02 1143 169387 405961 90051956
Bone pain 79.69 22.02 11 170519 61972 90395945
Dysgeusia 79.00 22.02 5 170525 52555 90405362
Sinusitis 78.79 22.02 989 169541 342099 90115818
Migraine 78.52 22.02 620 169910 189772 90268145
Myositis 78.32 22.02 153 170377 23975 90433942
Weight increased 77.72 22.02 1160 169370 416767 90041150
Swelling face 75.88 22.02 29 170501 81323 90376594
Skin exfoliation 74.54 22.02 18 170512 67895 90390022
Stress 74.29 22.02 30 170500 81365 90376552
Illness 73.54 22.02 31 170499 81938 90375979
Victim of sexual abuse 71.63 22.02 32 170498 663 90457254
Alanine aminotransferase increased 70.58 22.02 71 170459 118267 90339650
Blood pressure fluctuation 70.55 22.02 8 170522 52405 90405512
Femur fracture 70.43 22.02 4 170526 46078 90411839
Pneumonitis 70.17 22.02 3 170527 44167 90413750
Bradycardia 70.11 22.02 35 170495 83812 90374105
Vertigo 70.08 22.02 22 170508 69789 90388128
Knee arthroplasty 69.80 22.02 326 170204 82856 90375061
Hypotension 69.01 22.02 346 170184 325051 90132866
Dry eye 68.39 22.02 13 170517 57918 90399999
Ascites 67.61 22.02 6 170524 47734 90410183
Lymphadenopathy 66.92 22.02 5 170525 45770 90412147
Hot flush 66.81 22.02 15 170515 59473 90398444
Hyperkalaemia 66.07 22.02 20 170510 64944 90392973
Cognitive disorder 65.97 22.02 24 170506 69383 90388534
Musculoskeletal pain 65.91 22.02 549 169981 170702 90287215
Pain in jaw 65.41 22.02 7 170523 47978 90409939
Abdominal pain 65.25 22.02 456 170074 395265 90062652
Red blood cell count decreased 65.18 22.02 6 170524 46345 90411572
Drug interaction 64.47 22.02 284 170246 276169 90181748
Therapy interrupted 64.17 22.02 9 170521 50099 90407818
Angioedema 64.14 22.02 21 170509 64855 90393062
Musculoskeletal stiffness 63.92 22.02 845 169685 295687 90162230
Nail disorder 63.86 22.02 250 170280 58817 90399100
Mouth ulceration 62.57 22.02 3 170527 39971 90417946
Alcoholism 62.15 22.02 40 170490 1760 90456157
Adverse event 62.08 22.02 406 170124 117012 90340905
Leukopenia 61.71 22.02 59 170471 100651 90357266
Drug reaction with eosinophilia and systemic symptoms 61.58 22.02 5 170525 42753 90415164
Cholelithiasis 61.52 22.02 12 170518 52494 90405423
Breast cancer 61.51 22.02 13 170517 53748 90404169
Cardiac disorder 60.63 22.02 16 170514 56856 90401061
Diverticulitis 60.56 22.02 7 170523 45180 90412737
Hypothyroidism 60.47 22.02 13 170517 53114 90404803
Ear infection 60.42 22.02 276 170254 69499 90388418
Drug-induced liver injury 60.35 22.02 332 170198 89986 90367931
Skin ulcer 59.62 22.02 11 170519 50064 90407853
Neoplasm progression 59.35 22.02 7 170523 44479 90413438
Oxygen saturation decreased 59.10 22.02 69 170461 107414 90350503
Rash maculo-papular 58.36 22.02 5 170525 40928 90416989
Aspartate aminotransferase increased 57.77 22.02 65 170465 102872 90355045
Transient ischaemic attack 57.10 22.02 7 170523 43169 90414748
Live birth 57.08 22.02 297 170233 78810 90379107
Viral infection 56.56 22.02 6 170524 41408 90416509
Full blood count abnormal 56.48 22.02 3 170527 36594 90421323
Joint swelling 56.07 22.02 1290 169240 502010 89955907
Postmortem blood drug level abnormal 55.31 22.02 20 170510 232 90457685
Heart rate decreased 55.27 22.02 16 170514 53489 90404428
Hyperglycaemia 54.99 22.02 14 170516 50956 90406961
Swollen tongue 54.92 22.02 10 170520 45946 90411971
Dyspnoea 54.75 22.02 1252 169278 879703 89578214
Eczema 54.26 22.02 16 170514 52854 90405063
Limb discomfort 53.32 22.02 5 170525 38055 90419862
Dysuria 53.07 22.02 6 170524 39395 90418522
Swollen joint count 52.82 22.02 73 170457 8580 90449337
Haematocrit decreased 52.44 22.02 8 170522 41824 90416093
Methaemoglobinaemia 52.05 22.02 50 170480 3965 90453952
Fungal infection 51.59 22.02 9 170521 42652 90415265
Pulmonary hypertension 51.36 22.02 9 170521 42514 90415403
Wrong technique in product usage process 51.20 22.02 36 170494 71535 90386382
Hypocalcaemia 51.10 22.02 9 170521 42359 90415558
Abortion spontaneous 50.86 22.02 19 170511 54037 90403880
Haemoptysis 50.59 22.02 3 170527 33317 90424600
Peripheral swelling 50.47 22.02 1073 169457 412033 90045884
Chronic kidney disease 50.05 22.02 16 170514 50175 90407742
Haemorrhage 49.49 22.02 35 170495 69334 90388583
Oral pain 49.45 22.02 3 170527 32680 90425237
Neoplasm malignant 48.69 22.02 4 170526 33876 90424041
Victim of chemical submission 48.62 22.02 25 170505 714 90457203
Blood ethanol increased 48.29 22.02 15 170515 104 90457813
Tinnitus 48.14 22.02 11 170519 43091 90414826
Procedural pain 47.77 22.02 4 170526 33356 90424561
Aphasia 47.67 22.02 11 170519 42801 90415116
Flatulence 47.33 22.02 10 170520 41357 90416560
Premature delivery 47.27 22.02 8 170522 38754 90419163
Unevaluable event 47.22 22.02 22 170508 54826 90403091
Hypomagnesaemia 46.50 22.02 6 170524 35582 90422335
Candida infection 46.34 22.02 5 170525 34052 90423865
Angina pectoris 45.77 22.02 9 170521 39151 90418766
Disease recurrence 45.41 22.02 8 170522 37645 90420272
Cholestasis 45.37 22.02 7 170523 36292 90421625
Gastric disorder 45.17 22.02 5 170525 33379 90424538
Abdominal pain lower 44.97 22.02 3 170527 30174 90427743
Skin lesion 44.93 22.02 8 170522 37357 90420560
Hypophagia 44.76 22.02 7 170523 35930 90421987
Cerebral haemorrhage 44.68 22.02 6 170524 34516 90423401
Respiratory tract infection 44.58 22.02 28 170502 59050 90398867
Adverse reaction 44.44 22.02 140 170390 29572 90428345
Skin discolouration 44.42 22.02 14 170516 44301 90413616
Renal disorder 43.63 22.02 9 170521 37850 90420067
Blood alkaline phosphatase increased 43.42 22.02 18 170512 48061 90409856
Nephrolithiasis 43.33 22.02 19 170511 49066 90408851
Localised infection 43.04 22.02 6 170524 33556 90424361
Dizziness 42.55 22.02 817 169713 588467 89869450
Metastases to liver 42.53 22.02 3 170527 28804 90429113
Rash macular 42.36 22.02 4 170526 30276 90427641
Orthostatic hypotension 42.31 22.02 13 170517 41814 90416103
Anaphylactic shock 42.12 22.02 5 170525 31612 90426305
Bronchitis 42.08 22.02 147 170383 152780 90305137
C-reactive protein increased 42.05 22.02 524 170006 180865 90277052
Hypertension 41.81 22.02 1142 169388 456390 90001527
Accidental death 41.72 22.02 33 170497 2015 90455902
Toxic epidermal necrolysis 41.28 22.02 6 170524 32522 90425395
Finger deformity 41.20 22.02 146 170384 32751 90425166
Therapy cessation 41.17 22.02 9 170521 36352 90421565
Eye pain 40.76 22.02 16 170514 44152 90413765
Gastritis 40.43 22.02 14 170516 41739 90416178
Hip fracture 39.95 22.02 7 170523 33070 90424847
Blepharospasm 39.88 22.02 208 170322 55237 90402680
Skin disorder 39.75 22.02 10 170520 36696 90421221
Haematoma 39.74 22.02 12 170518 39036 90418881
Drug tolerance decreased 39.73 22.02 142 170388 31988 90425929
Blood calcium decreased 39.65 22.02 5 170525 30177 90427740
Diplopia 39.62 22.02 4 170526 28710 90429207
Neuralgia 39.54 22.02 6 170524 31494 90426423
Urinary incontinence 39.23 22.02 11 170519 37555 90420362
Seronegative arthritis 39.18 22.02 98 170432 18136 90439781
Arthralgia 39.09 22.02 1141 169389 777381 89680536
Tooth disorder 38.85 22.02 6 170524 31084 90426833
Melaena 38.63 22.02 9 170521 34788 90423129
Back injury 38.57 22.02 182 170348 46440 90411477
Blindness 38.56 22.02 3 170527 26565 90431352
Blood potassium decreased 38.30 22.02 21 170509 47706 90410211
Eye swelling 38.29 22.02 5 170525 29381 90428536
Osteonecrosis 37.98 22.02 3 170527 26238 90431679
Red blood cell sedimentation rate increased 37.97 22.02 276 170254 82319 90375598
Staphylococcal infection 37.89 22.02 22 170508 48417 90409500
Pulmonary arterial hypertension 37.88 22.02 3 170527 26184 90431733
Drug resistance 37.76 22.02 6 170524 30443 90427474
Eye pruritus 37.67 22.02 5 170525 29022 90428895
Contraindicated product administered 37.62 22.02 827 169703 319312 90138605
Gastric ulcer 37.42 22.02 4 170526 27444 90430473
Limb injury 37.34 22.02 7 170523 31501 90426416
Hypervolaemia 37.31 22.02 8 170522 32749 90425168
Device related infection 37.18 22.02 3 170527 25783 90432134
Joint stiffness 37.15 22.02 263 170267 77779 90380138
Vaginal haemorrhage 36.95 22.02 7 170523 31264 90426653
Acute myocardial infarction 36.84 22.02 10 170520 34880 90423037
Eosinophilia 36.83 22.02 5 170525 28528 90429389
Lacrimation increased 36.75 22.02 4 170526 27058 90430859
Metastases to bone 36.68 22.02 3 170527 25502 90432415
Tenderness 36.42 22.02 4 170526 26864 90431053
Drug ineffective for unapproved indication 36.40 22.02 43 170487 66601 90391316
Emotional distress 36.01 22.02 12 170518 36650 90421267
Stevens-Johnson syndrome 35.96 22.02 6 170524 29370 90428547
Dyskinesia 35.81 22.02 12 170518 36522 90421395
Hemiparesis 35.78 22.02 8 170522 31811 90426106
Osteomyelitis 35.66 22.02 5 170525 27841 90430076
Lip swelling 35.61 22.02 14 170516 38596 90419321
Paraesthesia oral 35.52 22.02 8 170522 31651 90426266
Movement disorder 35.36 22.02 6 170524 29013 90428904
Liver function test increased 35.32 22.02 277 170253 84578 90373339
Product prescribing error 35.08 22.02 7 170523 30138 90427779
Feeling cold 35.01 22.02 5 170525 27460 90430457
Product label confusion 34.48 22.02 108 170422 22742 90435175
Incorrect route of product administration 34.42 22.02 187 170343 50439 90407478
Sleep disorder due to a general medical condition 34.39 22.02 171 170359 44567 90413350
Pancreatitis acute 34.30 22.02 9 170521 32106 90425811
Food allergy 34.01 22.02 4 170526 25474 90432443
Carpal tunnel syndrome 33.90 22.02 3 170527 23925 90433992
Speech disorder 33.85 22.02 22 170508 45563 90412354
Clostridium difficile colitis 33.72 22.02 5 170525 26701 90431216
Nodule 33.69 22.02 5 170525 26681 90431236
Eye irritation 33.58 22.02 11 170519 33967 90423950
Gastroenteritis 33.58 22.02 7 170523 29222 90428695
Therapeutic product effect decreased 33.55 22.02 720 169810 276851 90181066
Joint injury 33.31 22.02 10 170520 32654 90425263
Immunodeficiency 33.30 22.02 20 170510 43214 90414703
Liver function test abnormal 33.28 22.02 28 170502 50817 90407100
Dysstasia 33.28 22.02 4 170526 25048 90432869
Blood pressure decreased 33.27 22.02 56 170474 74839 90383078
Rib fracture 33.26 22.02 5 170525 26430 90431487
Abdominal discomfort 33.09 22.02 1152 169378 476176 89981741
Alopecia 32.88 22.02 1189 169341 493882 89964035
Oral herpes 32.88 22.02 11 170519 33513 90424404
Urinary retention 32.71 22.02 15 170515 37729 90420188
Blood lactate dehydrogenase increased 32.41 22.02 5 170525 25927 90431990
Kidney infection 32.38 22.02 5 170525 25911 90432006
Intervertebral disc protrusion 32.32 22.02 6 170524 27190 90430727
Pregnancy 31.85 22.02 213 170317 61834 90396083
Haematuria 31.68 22.02 13 170517 34924 90422993
Haemorrhoids 31.50 22.02 6 170524 26696 90431221
Haematemesis 31.48 22.02 12 170518 33714 90424203
Posterior reversible encephalopathy syndrome 31.12 22.02 3 170527 22336 90435581
Premature baby 30.97 22.02 5 170525 25072 90432845
Hepatic function abnormal 30.91 22.02 25 170505 46263 90411654
Product formulation issue 30.80 22.02 18 170512 665 90457252
Asphyxia 30.67 22.02 51 170479 7052 90450865
Bacterial infection 30.52 22.02 4 170526 23440 90434477
Acne 30.42 22.02 8 170522 28499 90429418
Colitis ulcerative 30.40 22.02 206 170324 60060 90397857
Frequent bowel movements 30.16 22.02 197 170333 56738 90401179
Gamma-glutamyltransferase increased 30.02 22.02 17 170513 37935 90419982
Bone disorder 29.96 22.02 4 170526 23116 90434801
Blood urea increased 29.79 22.02 10 170520 30403 90427514
Upper gastrointestinal haemorrhage 29.72 22.02 4 170526 22972 90434945
Coronary artery disease 29.70 22.02 13 170517 33610 90424307
Gastroenteritis viral 29.70 22.02 10 170520 30345 90427572
Heart rate irregular 29.61 22.02 5 170525 24263 90433654
Therapeutic response shortened 29.55 22.02 4 170526 22875 90435042
Electrocardiogram QRS complex prolonged 29.40 22.02 51 170479 7297 90450620
Foot fracture 29.30 22.02 7 170523 26599 90431318
Surgery 29.04 22.02 25 170505 44862 90413055
Hepatic cytolysis 28.86 22.02 11 170519 30905 90427012
Pollakiuria 28.78 22.02 13 170517 32992 90424925
Hypoxia 28.72 22.02 58 170472 72341 90385576
Blood test abnormal 28.70 22.02 3 170527 20949 90436968
Iron deficiency anaemia 28.60 22.02 5 170525 23657 90434260
Presyncope 28.57 22.02 12 170518 31793 90426124
Sleep apnoea syndrome 28.48 22.02 12 170518 31735 90426182
Toothache 28.44 22.02 4 170526 22226 90435691
Throat tightness 28.35 22.02 10 170520 29474 90428443
Foetal death 28.30 22.02 3 170527 20720 90437197
Fracture 28.18 22.02 4 170526 22072 90435845
Malaise 28.08 22.02 864 169666 585122 89872795
Pharyngitis 27.96 22.02 4 170526 21943 90435974
Product dose omission in error 27.92 22.02 3 170527 20500 90437417
Diabetic ketoacidosis 27.72 22.02 6 170524 24401 90433516
Rash papular 27.66 22.02 3 170527 20352 90437565
Head injury 27.64 22.02 12 170518 31176 90426741
Drug dependence 27.64 22.02 119 170411 29208 90428709
Conjunctivitis 27.56 22.02 8 170522 26698 90431219
Hepatocellular injury 27.54 22.02 10 170520 28948 90428969
Osteopenia 27.49 22.02 5 170525 22997 90434920
Product storage error 27.47 22.02 3 170527 20238 90437679
Pallor 27.46 22.02 15 170515 34150 90423767
Seasonal allergy 27.46 22.02 5 170525 22978 90434939
Red blood cell sedimentation rate abnormal 27.39 22.02 6 170524 24198 90433719
Cerebral infarction 27.38 22.02 8 170522 26588 90431329
Hiatus hernia 27.29 22.02 7 170523 25354 90432563
Blood sodium decreased 27.18 22.02 9 170521 27604 90430313
Tendonitis 26.99 22.02 4 170526 21368 90436549
Multiple organ dysfunction syndrome 26.89 22.02 55 170475 68281 90389636
Photophobia 26.81 22.02 4 170526 21265 90436652
Mitral valve incompetence 26.70 22.02 5 170525 22519 90435398
Deafness 26.68 22.02 5 170525 22509 90435408
Musculoskeletal chest pain 26.65 22.02 6 170524 23744 90434173
International normalised ratio increased 26.41 22.02 30 170500 47286 90410631
Obstructive airways disorder 26.24 22.02 8 170522 25861 90432056
Disturbance in attention 26.15 22.02 30 170500 47079 90410838
Skin fissures 26.03 22.02 4 170526 20805 90437112
Blood bilirubin increased 26.01 22.02 26 170504 43444 90414473
Glaucoma 25.94 22.02 4 170526 20751 90437166
Therapy partial responder 25.90 22.02 5 170525 22038 90435879
Bronchospasm 25.87 22.02 4 170526 20705 90437212
Spinal fracture 25.86 22.02 5 170525 22011 90435906
Impaired quality of life 25.66 22.02 6 170524 23138 90434779
Sedation 25.33 22.02 32 170498 48139 90409778
Protein C increased 25.21 22.02 8 170522 60 90457857
Hallucination 25.19 22.02 54 170476 65905 90392012
Epilepsy 24.73 22.02 250 170280 81956 90375961
Nervousness 24.53 22.02 17 170513 34039 90423878
Acute respiratory failure 24.18 22.02 27 170503 42891 90415026
Blood pressure abnormal 24.07 22.02 4 170526 19641 90438276
COVID-19 pneumonia 23.90 22.02 3 170527 18174 90439743
Neutropenic sepsis 23.82 22.02 3 170527 18127 90439790
Vaginal discharge 23.77 22.02 4 170526 19460 90438457
Jaundice 23.73 22.02 16 170514 32501 90425416
Product substitution issue 23.61 22.02 3 170527 18005 90439912
Depression 23.50 22.02 736 169794 299865 90158052
Disinhibition 23.47 22.02 18 170512 1050 90456867
Heavy menstrual bleeding 23.41 22.02 5 170525 20525 90437392
Vomiting 23.35 22.02 1229 169301 787064 89670853
Spinal osteoarthritis 23.24 22.02 4 170526 19144 90438773
Ankle fracture 23.15 22.02 5 170525 20365 90437552
Eating disorder 23.04 22.02 12 170518 28061 90429856
Ocular hyperaemia 22.88 22.02 18 170512 33780 90424137
Osteoporosis 22.84 22.02 280 170250 96251 90361666
Poor quality sleep 22.69 22.02 9 170521 24684 90433233
Weight decreased 22.63 22.02 543 169987 379367 90078550
Visual acuity reduced 22.41 22.02 8 170522 23402 90434515
Aphthous ulcer 22.38 22.02 3 170527 17284 90440633
Musculoskeletal discomfort 22.19 22.02 6 170524 20985 90436932
Radiculopathy 22.17 22.02 4 170526 18501 90439416
Peritonitis 22.06 22.02 5 170525 19700 90438217

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 10943.49 18.14 4127 42637 100644 42473927
Completed suicide 8265.39 18.14 3299 43465 93166 42481405
Toxicity to various agents 6623.59 18.14 3697 43067 225439 42349132
Cardio-respiratory arrest 1811.89 18.14 998 45766 57638 42516933
Poisoning 1232.23 18.14 499 46265 14200 42560371
Intentional product misuse 1158.23 18.14 764 46000 61136 42513435
Intentional overdose 1135.90 18.14 705 46059 50751 42523820
Respiratory arrest 1016.68 18.14 534 46230 27890 42546681
Overdose 880.57 18.14 806 45958 104458 42470113
Alcohol abuse 726.49 18.14 241 46523 3808 42570763
Substance use disorder 679.64 18.14 246 46518 5099 42569472
Drug use disorder 633.20 18.14 281 46483 10052 42564519
Suicide attempt 610.12 18.14 461 46303 45639 42528932
Alcohol interaction 604.19 18.14 180 46584 1955 42572616
Cardiac arrest 586.80 18.14 659 46105 108661 42465910
Coma 545 18.14 459 46305 53095 42521476
Suspected suicide 500.42 18.14 205 46559 5994 42568577
Drug dependence 492.52 18.14 338 46426 28756 42545815
Exposure via ingestion 464.91 18.14 147 46617 1975 42572596
Death 464.47 18.14 1344 45420 469841 42104730
Substance abuse 432.18 18.14 206 46558 8699 42565872
Alcohol poisoning 429.01 18.14 195 46569 7379 42567192
Asphyxia 420.59 18.14 198 46566 8128 42566443
Poisoning deliberate 360.75 18.14 190 46574 9944 42564627
Exposure to toxic agent 348.55 18.14 149 46615 4855 42569716
Miosis 263.00 18.14 171 46593 13275 42561296
Aggression 260.19 18.14 280 46484 43883 42530688
Respiratory depression 258.89 18.14 193 46571 18675 42555896
Drug ineffective 243.48 18.14 202 46562 629995 41944576
Alcohol use 239.45 18.14 97 46667 2751 42571820
Off label use 231.64 18.14 217 46547 638118 41936453
Diarrhoea 226.49 18.14 112 46652 460737 42113834
Pyrexia 215.34 18.14 82 46682 393960 42180611
Fatigue 199.14 18.14 116 46648 435525 42139046
Pneumonia 196.38 18.14 110 46654 422039 42152532
Anaemia 180.68 18.14 43 46721 280235 42294336
Blood alcohol increased 175.89 18.14 52 46712 548 42574023
Accidental death 173.36 18.14 79 46685 3004 42571567
Neutropenia 166.78 18.14 14 46750 199417 42375154
Prescription drug used without a prescription 163.17 18.14 73 46691 2657 42571914
Agitation 155.29 18.14 264 46500 64050 42510521
Hypertrichosis 154.44 18.14 47 46717 551 42574020
Febrile neutropenia 147.42 18.14 16 46748 185687 42388884
Rash 143.95 18.14 62 46702 276892 42297679
Suicidal ideation 139.84 18.14 215 46549 47946 42526625
Disease progression 129.06 18.14 7 46757 143649 42430922
Tachycardia 122.04 18.14 312 46452 100775 42473796
Product formulation issue 121.30 18.14 42 46722 759 42573812
Dyspnoea 119.23 18.14 189 46575 442432 42132139
Cough 115.28 18.14 27 46737 178076 42396495
Mydriasis 114.24 18.14 87 46677 8683 42565888
Intentional self-injury 112.38 18.14 109 46655 15093 42559478
Depressed level of consciousness 109.32 18.14 192 46572 47778 42526793
Sepsis 106.10 18.14 43 46721 199291 42375280
Incorrect route of product administration 102.71 18.14 130 46634 24175 42550396
Platelet count decreased 102.51 18.14 15 46749 138566 42436005
Decreased appetite 100.63 18.14 43 46721 193094 42381477
Alcohol withdrawal syndrome 100.35 18.14 43 46721 1408 42573163
Drug screen positive 99.55 18.14 60 46704 4071 42570500
Malignant neoplasm progression 98.23 18.14 5 46759 108395 42466176
Arthralgia 95.83 18.14 53 46711 205185 42369386
Withdrawal syndrome 94.61 18.14 98 46666 14677 42559894
Bradypnoea 93.63 18.14 59 46705 4334 42570237
Constipation 89.67 18.14 33 46731 162258 42412313
Pain in extremity 89.54 18.14 27 46737 150577 42423994
Condition aggravated 88.99 18.14 93 46671 260661 42313910
Pain 86.20 18.14 85 46679 244763 42329808
Nausea 85.99 18.14 193 46571 396606 42177965
Pulmonary oedema 85.62 18.14 184 46580 53088 42521483
Thrombocytopenia 84.76 18.14 52 46712 190227 42384344
Drug withdrawal syndrome 84.38 18.14 111 46653 21438 42553133
White blood cell count decreased 79.24 18.14 13 46751 110383 42464188
Asthenia 79.18 18.14 116 46648 280677 42293894
Pancytopenia 77.85 18.14 17 46747 117726 42456845
Environmental exposure 73.15 18.14 22 46742 247 42574324
Blood ethanol increased 72.55 18.14 25 46739 445 42574126
Methaemoglobinaemia 72.40 18.14 56 46708 5718 42568853
Alcoholism 71.75 18.14 43 46721 2887 42571684
Interstitial lung disease 69.88 18.14 4 46760 78458 42496113
Altered state of consciousness 67.79 18.14 118 46646 29141 42545430
Product dose omission issue 67.59 18.14 43 46721 154322 42420249
Nasopharyngitis 67.19 18.14 7 46757 83989 42490582
Neuropathy peripheral 66.73 18.14 15 46749 101838 42472733
Alcohol intolerance 66.13 18.14 22 46742 350 42574221
Unresponsive to stimuli 64.27 18.14 120 46644 31283 42543288
Impaired driving ability 63.76 18.14 40 46724 2915 42571656
Intentional product use issue 63.36 18.14 198 46566 71635 42502936
Dehydration 61.37 18.14 40 46724 141727 42432844
Medication error 60.88 18.14 121 46643 33033 42541538
Weight decreased 60.45 18.14 84 46680 207864 42366707
Back pain 58.70 18.14 42 46722 141734 42432837
Somnolence 58.24 18.14 307 46457 140798 42433773
Road traffic accident 57.87 18.14 87 46677 19006 42555565
Malaise 57.47 18.14 90 46674 212066 42362505
Pruritus 57.15 18.14 74 46690 188697 42385874
Septic shock 57.12 18.14 15 46749 91657 42482914
Behavioural addiction 55.93 18.14 14 46750 73 42574498
Infection 55.13 18.14 27 46737 112041 42462530
Drug intolerance 54.40 18.14 11 46753 80413 42494158
Accidental overdose 53.96 18.14 105 46659 28225 42546346
Renal impairment 53.55 18.14 27 46737 110201 42464370
Pulmonary embolism 52.79 18.14 33 46731 119579 42454992
General physical health deterioration 52.59 18.14 53 46711 151193 42423378
Suicidal behaviour 52.21 18.14 28 46736 1518 42573053
Peripheral swelling 52.16 18.14 17 46747 90253 42484318
Loss of consciousness 52.03 18.14 220 46544 92134 42482437
Urinary tract infection 51.82 18.14 22 46742 99262 42475309
Ex-drug abuser 51.74 18.14 13 46751 69 42574502
Amnesia 50.08 18.14 102 46662 28335 42546236
COVID-19 47.14 18.14 35 46729 115913 42458658
Sopor 47.09 18.14 65 46699 13137 42561434
Cerebrovascular accident 46.89 18.14 24 46740 97136 42477435
Urticaria 46.34 18.14 12 46752 74024 42500547
Dizziness 46.28 18.14 131 46633 249123 42325448
Abnormal behaviour 45.54 18.14 94 46670 26357 42548214
Asthma 45.46 18.14 7 46757 62307 42512264
Erythema 44.02 18.14 33 46731 108760 42465811
Infusion related reaction 43.97 18.14 7 46757 60799 42513772
Haematochezia 43.94 18.14 6 46758 58430 42516141
Homicide 43.86 18.14 21 46743 894 42573677
Drug abuser 43.73 18.14 34 46730 3497 42571074
Deep vein thrombosis 43.57 18.14 15 46749 76942 42497629
Physical assault 43.42 18.14 22 46742 1060 42573511
Metabolic acidosis 43.03 18.14 140 46624 51718 42522853
Haemoglobin decreased 42.09 18.14 50 46714 132421 42442150
Dysphagia 41.47 18.14 14 46750 72705 42501866
Chills 41.43 18.14 26 46738 94040 42480531
Pericardial effusion 41.27 18.14 96 46668 29179 42545392
Influenza 41.03 18.14 9 46755 62166 42512405
Blood ethanol 40.70 18.14 11 46753 81 42574490
Brain oedema 40.65 18.14 68 46696 16259 42558312
Acute kidney injury 39.96 18.14 238 46526 367099 42207472
Chronic obstructive pulmonary disease 39.94 18.14 10 46754 63104 42511467
Productive cough 39.48 18.14 5 46759 51562 42523009
Abdominal pain 39.23 18.14 95 46669 190376 42384195
Cardiac failure 37.64 18.14 37 46727 106819 42467752
Treatment failure 37.59 18.14 11 46753 62613 42511958
Joint swelling 37.24 18.14 14 46750 68008 42506563
Atrial fibrillation 37.03 18.14 60 46704 139533 42435038
Leukopenia 36.76 18.14 18 46746 74728 42499843
Haemoptysis 36.52 18.14 4 46760 46163 42528408
Inappropriate schedule of product administration 36.40 18.14 31 46733 95871 42478700
Abdominal distension 35.70 18.14 17 46747 71718 42502853
Plasma cell myeloma 35.50 18.14 5 46759 47573 42526998
Toxicologic test abnormal 35.18 18.14 15 46749 485 42574086
Hypothermia 35.07 18.14 55 46709 12460 42562111
Prostate cancer 34.98 18.14 4 46760 44639 42529932
Cellulitis 34.87 18.14 12 46752 61573 42512998
Myocardial fibrosis 34.60 18.14 20 46744 1255 42573316
Abdominal discomfort 34.25 18.14 20 46744 75235 42499336
Product use in unapproved indication 34.16 18.14 97 46667 184359 42390212
Wheezing 34.04 18.14 9 46755 54772 42519799
Opiates positive 33.88 18.14 15 46749 532 42574039
Stomatitis 33.79 18.14 7 46757 50322 42524249
Cluster headache 33.49 18.14 15 46749 547 42574024
Loss of personal independence in daily activities 33.30 18.14 7 46757 49809 42524762
Gastrointestinal disorder 32.35 18.14 6 46758 46647 42527924
Pneumonitis 32.04 18.14 4 46760 41714 42532857
Drug interaction 31.75 18.14 439 46325 266560 42308011
Dysarthria 31.70 18.14 106 46658 39701 42534870
Headache 31.65 18.14 145 46619 239224 42335347
Foetal alcohol syndrome 31.52 18.14 9 46755 83 42574488
Epistaxis 31.51 18.14 17 46747 66809 42507762
Potentiating drug interaction 31.20 18.14 37 46727 6431 42568140
Shock 31.13 18.14 86 46678 29035 42545536
Hepatitis C virus test positive 30.73 18.14 12 46752 308 42574263
Gun shot wound 30.11 18.14 17 46747 1020 42573551
Haematuria 29.84 18.14 13 46751 57786 42516785
Herpes zoster 29.20 18.14 4 46760 38873 42535698
Therapy non-responder 29.18 18.14 11 46753 53348 42521223
Exposure via inhalation 29.09 18.14 7 46757 30 42574541
Adulterated product 29.07 18.14 15 46749 751 42573820
Sinusitis 28.95 18.14 8 46756 47284 42527287
Hepatic fibrosis 28.84 18.14 31 46733 4841 42569730
Delirium tremens 28.77 18.14 14 46750 618 42573953
Behaviour disorder 28.64 18.14 37 46727 7017 42567554
Oropharyngeal pain 28.36 18.14 6 46758 42504 42532067
Postmortem blood drug level increased 28.19 18.14 13 46751 508 42574063
Hepatic steatosis 27.71 18.14 68 46696 21380 42553191
Mucosal inflammation 27.30 18.14 10 46754 49364 42525207
Therapeutic product effect decreased 27.22 18.14 5 46759 39145 42535426
Pulmonary congestion 27.19 18.14 56 46708 15674 42558897
Pupil fixed 27.15 18.14 20 46744 1897 42572674
Bronchitis 27.06 18.14 9 46755 47192 42527379
Dysgeusia 26.95 18.14 3 46761 34186 42540385
Blood glucose increased 26.55 18.14 25 46739 73674 42500897
Fall 26.49 18.14 150 46614 234370 42340201
Thrombosis 26.17 18.14 22 46742 68489 42506082
Upper respiratory tract infection 26.07 18.14 7 46757 42166 42532405
C-reactive protein increased 26.06 18.14 19 46745 63541 42511030
Postmortem blood drug level 26.02 18.14 9 46755 162 42574409
Electrocardiogram QRS complex prolonged 25.95 18.14 32 46732 5791 42568780
Hospitalisation 25.87 18.14 26 46738 74304 42500267
Product label on wrong product 25.85 18.14 7 46757 52 42574519
Self-medication 25.23 18.14 24 46740 3242 42571329
Acidosis 25.21 18.14 47 46717 12232 42562339
Sinus tachycardia 25.13 18.14 64 46700 20589 42553982
Cytomegalovirus infection 25.05 18.14 3 46761 32303 42542268
Pneumonia aspiration 24.92 18.14 115 46649 49963 42524608
Dextrocardia 24.66 18.14 7 46757 63 42574508
Aspiration 24.49 18.14 58 46706 17828 42556743
Substance use 24.20 18.14 18 46746 1733 42572838
Accidental poisoning 24.15 18.14 16 46748 1280 42573291
Musculoskeletal stiffness 24.03 18.14 17 46747 57748 42516823
Myalgia 23.90 18.14 43 46721 96037 42478534
Hyponatraemia 23.84 18.14 47 46717 101415 42473156
Muscle spasms 23.74 18.14 36 46728 86008 42488563
Accidental exposure to product 23.58 18.14 62 46702 20331 42554240
Coma scale abnormal 23.50 18.14 27 46737 4538 42570033
Left ventricular hypertrophy 23.45 18.14 39 46725 9280 42565291
Restlessness 23.39 18.14 78 46686 29171 42545400
Sensorimotor disorder 23.36 18.14 11 46753 451 42574120
Therapeutic product effect incomplete 23.35 18.14 26 46738 70913 42503658
Alcoholic coma 23.32 18.14 7 46757 78 42574493
Chest pain 23.24 18.14 77 46687 139453 42435118
Electrocardiogram repolarisation abnormality 23.00 18.14 14 46750 967 42573604
Mixed anxiety and depressive disorder 22.94 18.14 9 46755 234 42574337
Weight increased 22.89 18.14 53 46711 107930 42466641
Drug ineffective for unapproved indication 22.87 18.14 11 46753 46152 42528419
Rectal haemorrhage 22.83 18.14 13 46751 49593 42524978
Somnambulism 22.49 18.14 23 46741 3392 42571179
Eczema 22.35 18.14 5 46759 34081 42540490
Hypersensitivity 22.25 18.14 28 46736 72342 42502229
Diabetes mellitus 22.09 18.14 20 46744 60067 42514504
Renal cyst haemorrhage 21.92 18.14 12 46752 678 42573893
Rash pruritic 21.89 18.14 5 46759 33598 42540973
Dyspnoea exertional 21.88 18.14 14 46750 50134 42524437
Mobility decreased 21.56 18.14 6 46758 35300 42539271
Injection site pain 21.54 18.14 19 46745 57779 42516792
Analgesic drug level increased 21.43 18.14 14 46750 1094 42573477
Eosinophilia 21.22 18.14 5 46759 32894 42541677
Rectal prolapse 21.20 18.14 11 46753 557 42574014
Nephrolithiasis 21.15 18.14 7 46757 36823 42537748
Muscular weakness 21.10 18.14 37 46727 83461 42491110
Agranulocytosis 21.09 18.14 4 46760 30608 42543963
Drug level increased 21.06 18.14 70 46694 26130 42548441
Substance-induced mood disorder 21.04 18.14 6 46758 55 42574516
Alcoholic liver disease 21.04 18.14 11 46753 566 42574005
Acute hepatic failure 20.87 18.14 53 46711 17020 42557551
Respiratory acidosis 20.84 18.14 30 46734 6301 42568270
Amphetamines positive 20.76 18.14 8 46756 198 42574373
Bacterial infection 20.63 18.14 3 46761 27876 42546695
Drug diversion 20.39 18.14 13 46751 974 42573597
Visceral oedema 20.31 18.14 6 46758 63 42574508
Renal failure 20.22 18.14 85 46679 143641 42430930
Lower respiratory tract infection 20.14 18.14 10 46754 41196 42533375
Anaphylactic reaction 19.96 18.14 11 46753 42732 42531839
Legal problem 19.74 18.14 7 46757 136 42574435
Toxic epidermal necrolysis 19.52 18.14 3 46761 26747 42547824
Pulmonary fibrosis 19.45 18.14 3 46761 26678 42547893
Chemical submission 19.08 18.14 6 46758 79 42574492
Colitis ulcerative 18.95 18.14 3 46761 26172 42548399
Liver disorder 18.81 18.14 10 46754 39634 42534937
Dyspepsia 18.80 18.14 11 46753 41341 42533230
Toxic leukoencephalopathy 18.66 18.14 11 46753 716 42573855
Lymphocyte count decreased 18.39 18.14 4 46760 27805 42546766
Transient ischaemic attack 18.37 18.14 7 46757 33732 42540839
Psychiatric disorder prophylaxis 18.36 18.14 5 46759 38 42574533

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 15026.69 17.97 7440 170548 234941 110176370
Drug abuse 11745.97 17.97 5704 172284 171707 110239604
Toxicity to various agents 8850.39 17.97 6796 171192 473759 109937552
Cardio-respiratory arrest 2972.40 17.97 2013 175975 113823 110297488
Respiratory arrest 1746.50 17.97 1117 176871 57182 110354129
Poisoning 1676.86 17.97 855 177133 28250 110383061
Intentional overdose 1562.39 17.97 1458 176530 131043 110280268
Intentional product misuse 1312.38 17.97 1327 176661 131577 110279734
Overdose 1094.93 17.97 1599 176389 232195 110179116
Alcohol interaction 945.73 17.97 316 177672 3378 110407933
Cardiac arrest 944.72 17.97 1362 176626 195391 110215920
Suspected suicide 796.17 17.97 419 177569 14780 110396531
Substance use disorder 766.47 17.97 325 177663 6965 110404346
Suicide attempt 687.61 17.97 840 177148 102554 110308757
Drug use disorder 664.83 17.97 395 177593 17679 110393632
Alcohol abuse 658.91 17.97 261 177727 4668 110406643
Exposure via ingestion 646.44 17.97 257 177731 4643 110406668
Death 639.84 17.97 2516 175472 696353 109714958
Anaemia 630.08 17.97 72 177916 547014 109864297
Exposure to toxic agent 615.92 17.97 334 177654 12524 110398787
Alcohol poisoning 575.23 17.97 284 177704 8736 110402575
Alcohol use 532.66 17.97 213 177775 3909 110407402
Cough 504.21 17.97 72 177916 461569 109949742
Drug ineffective 500.76 17.97 1066 176922 1519474 108891837
Neutropenia 496.13 17.97 26 177962 374594 110036717
Coma 467.42 17.97 747 177241 117122 110294189
Irritable bowel syndrome 448.71 17.97 884 177104 163331 110247980
Poisoning deliberate 448.59 17.97 358 177630 25973 110385338
Ill-defined disorder 446.39 17.97 859 177129 155994 110255317
Rheumatic fever 437.72 17.97 741 177247 121838 110289473
Diarrhoea 427.58 17.97 738 177250 1138767 109272544
Febrile neutropenia 422.51 17.97 21 177967 316746 110094565
Folliculitis 419.36 17.97 870 177118 166783 110244528
Helicobacter infection 400.12 17.97 896 177092 180981 110230330
Substance abuse 395.87 17.97 248 177740 12215 110399096
Constipation 392.44 17.97 55 177933 357731 110053580
Lip dry 385.46 17.97 626 177362 99457 110311854
Muscle injury 383.42 17.97 757 177231 140050 110271261
Facet joint syndrome 378.85 17.97 610 177378 96218 110315093
Injury 375.15 17.97 860 177128 176405 110234906
Off label use 361.60 17.97 1226 176762 1498959 108912352
Joint range of motion decreased 354.91 17.97 674 177314 121158 110290153
Drug dependence 351.34 17.97 418 177570 49602 110361709
Type 2 diabetes mellitus 350.11 17.97 837 177151 176395 110234916
Duodenal ulcer perforation 332.64 17.97 822 177166 176878 110234433
Acute kidney injury 332.29 17.97 320 177668 635110 109776201
Urinary tract infection 331.27 17.97 62 177926 326220 110085091
Hand deformity 328.98 17.97 932 177056 217574 110193737
Sepsis 328.54 17.97 64 177924 327282 110084029
Glossodynia 324.61 17.97 937 177051 221067 110190244
Sleep disorder 319.50 17.97 868 177120 197776 110213535
Road traffic accident 318.82 17.97 599 177389 106799 110304512
Disease progression 313.60 17.97 20 177968 244014 110167297
Asphyxia 312.32 17.97 225 177763 13990 110397321
Impaired healing 311.82 17.97 855 177133 195862 110215449
Pemphigus 311.17 17.97 903 177085 213667 110197644
Sleep disorder due to general medical condition, insomnia type 309.61 17.97 586 177402 105057 110306254
Liver injury 303.15 17.97 716 177272 149697 110261614
Wound 298.99 17.97 943 177045 233494 110177817
C-reactive protein abnormal 297.62 17.97 650 177338 129045 110282266
Back pain 290.05 17.97 117 177871 370879 110040432
Nausea 289.70 17.97 1021 176967 1234669 109176642
Product dose omission issue 289.01 17.97 80 177908 321702 110089609
Pericarditis 286.44 17.97 889 177099 218225 110193086
Swollen joint count increased 283.15 17.97 494 177494 83167 110328144
Pneumonia 278.82 17.97 625 177363 876089 109535222
Systemic lupus erythematosus 277.95 17.97 971 177017 253367 110157944
Fatigue 276.18 17.97 1018 176970 1214940 109196371
Erythema 276.07 17.97 65 177923 291382 110119929
Dehydration 275.54 17.97 57 177931 279454 110131857
White blood cell count decreased 274.54 17.97 26 177962 229364 110181947
Rheumatoid factor positive 270.00 17.97 631 177357 131009 110280302
Platelet count decreased 263.27 17.97 31 177957 230412 110180899
Psoriatic arthropathy 262.45 17.97 804 177184 195957 110215354
Breast cancer stage III 258.47 17.97 460 177528 78657 110332654
Fibromyalgia 253.27 17.97 725 177263 170184 110241127
Pancytopenia 250.20 17.97 24 177964 209589 110201722
Victim of crime 248.92 17.97 91 177897 1292 110410019
Malignant neoplasm progression 241.20 17.97 9 177979 174558 110236753
Blood alcohol increased 239.89 17.97 82 177906 944 110410367
Amnesia 239.21 17.97 526 177462 104882 110306429
Hypertrichosis 230.16 17.97 92 177896 1686 110409625
Lupus vulgaris 229.48 17.97 278 177710 33605 110377706
Fall 229.13 17.97 387 177601 603095 109808216
Deep vein thrombosis postoperative 228.40 17.97 371 177617 58920 110352391
Adjustment disorder with depressed mood 228.27 17.97 316 177672 43567 110367744
Haemoglobin decreased 226.77 17.97 60 177928 248667 110162644
Peripheral venous disease 226.18 17.97 450 177538 83667 110327644
X-ray abnormal 223.52 17.97 291 177697 37826 110373485
COVID-19 221.74 17.97 60 177928 245000 110166311
Dislocation of vertebra 221.70 17.97 311 177677 43410 110367901
Pulmonary embolism 214.98 17.97 42 177946 214432 110196879
Porphyria acute 206.35 17.97 199 177789 18581 110392730
Hypercholesterolaemia 200.14 17.97 448 177540 90389 110320922
Blood pressure increased 199.40 17.97 83 177905 258290 110153021
Anti-cyclic citrullinated peptide antibody positive 198.90 17.97 695 177293 181289 110230022
Lower limb fracture 198.87 17.97 400 177588 74948 110336363
Medication error 196.62 17.97 487 177501 104879 110306432
Neuropathy peripheral 195.42 17.97 28 177960 179249 110232062
Bursitis 191.34 17.97 550 177438 129368 110281943
Accidental death 190.81 17.97 112 177876 4897 110406414
Miosis 190.62 17.97 205 177783 21778 110389533
Interstitial lung disease 189.72 17.97 8 177980 139326 110271985
Chills 189.57 17.97 38 177950 190542 110220769
Grip strength decreased 187.49 17.97 405 177583 79769 110331542
Hyponatraemia 186.45 17.97 59 177929 217594 110193717
Septic shock 185.46 17.97 19 177969 157509 110253802
Injection site pain 184.41 17.97 32 177956 177890 110233421
Synovitis 184.18 17.97 901 177087 273191 110138120
Dyspnoea 183.82 17.97 1039 176949 1105833 109305478
Lower respiratory tract infection 181.49 17.97 824 177164 242282 110169029
Influenza 180.65 17.97 28 177960 169073 110242238
Wound infection 180.13 17.97 446 177542 96019 110315292
Mydriasis 177.15 17.97 198 177790 21959 110389352
Night sweats 175.33 17.97 544 177444 133439 110277872
Obesity 174.86 17.97 488 177500 112863 110298448
Thrombocytopenia 173.75 17.97 183 177805 348702 110062609
Blister 173.71 17.97 776 177212 226600 110184711
Onychomycosis 167.67 17.97 255 177733 38276 110373035
Cerebrovascular accident 166.61 17.97 43 177945 181241 110230070
Pyrexia 165.28 17.97 814 177174 897451 109513860
Autoimmune disorder 162.60 17.97 339 177649 65144 110346167
Neutrophil count decreased 161.21 17.97 8 177980 120933 110290378
Renal impairment 158.02 17.97 53 177935 188392 110222919
Sciatica 156.74 17.97 412 177576 91987 110319324
Herpes zoster 155.41 17.97 4 177984 108375 110302936
Onychomadesis 154.94 17.97 270 177718 45393 110365918
Retinitis 152.21 17.97 222 177766 32105 110379206
Stomatitis 151.60 17.97 845 177143 269397 110141914
Oropharyngeal pain 150.08 17.97 20 177968 135256 110276055
Blood cholesterol increased 148.22 17.97 640 177348 184145 110227166
Aggression 147.57 17.97 307 177681 58903 110352408
Discomfort 145.76 17.97 708 177280 213999 110197312
Intentional product use issue 145.65 17.97 785 177203 247121 110164190
Liver disorder 144.94 17.97 531 177457 141712 110269599
Mobility decreased 144.40 17.97 759 177229 236663 110174648
Dysphagia 143.92 17.97 35 177953 153565 110257746
Haematochezia 143.91 17.97 11 177977 115513 110295798
Chemical submission 142.06 17.97 48 177940 532 110410779
Myalgia 139.77 17.97 93 177895 222288 110189023
Respiratory depression 139.54 17.97 212 177776 31789 110379522
Cellulitis 138.92 17.97 19 177969 125997 110285314
Cardiac failure 137.30 17.97 65 177923 187561 110223750
Myelosuppression 137.13 17.97 3 177985 94337 110316974
Deep vein thrombosis 136.82 17.97 29 177959 139858 110271453
Chest discomfort 135.47 17.97 55 177933 173793 110237518
Syncope 133.76 17.97 80 177908 202456 110208855
Colitis 132.56 17.97 8 177980 102315 110308996
Inappropriate schedule of product administration 132.30 17.97 82 177906 203555 110207756
Product formulation issue 132.06 17.97 57 177931 1277 110410034
Hepatic enzyme increased 131.60 17.97 926 177062 319966 110091345
Anaphylactic reaction 131.44 17.97 15 177973 114285 110297026
Incorrect route of product administration 130.10 17.97 306 177682 63755 110347556
Headache 129.67 17.97 860 177128 881517 109529794
Lupus-like syndrome 129.13 17.97 234 177754 40558 110370753
Productive cough 128.97 17.97 16 177972 114289 110297022
Epistaxis 127.56 17.97 27 177961 130345 110280966
Dry mouth 126.97 17.97 647 177341 199301 110212010
Bone erosion 125.73 17.97 249 177739 46122 110365189
Inflammation 122.50 17.97 625 177363 192613 110218698
Blood ethanol increased 122.17 17.97 44 177944 597 110410714
Renal failure 121.81 17.97 111 177877 226463 110184848
Gait inability 121.61 17.97 488 177500 135888 110275423
Feeling abnormal 121.28 17.97 70 177918 180641 110230670
Exostosis 121.28 17.97 244 177744 45712 110365599
Prescription drug used without a prescription 118.46 17.97 86 177902 5410 110405901
Atrial fibrillation 118.20 17.97 117 177871 229525 110181786
Gastrointestinal haemorrhage 117.08 17.97 60 177928 165458 110245853
Chronic obstructive pulmonary disease 116.75 17.97 18 177970 109140 110302171
Maternal exposure timing unspecified 116.36 17.97 156 177832 20857 110390454
Asthenia 116.10 17.97 643 177345 688356 109722955
Rheumatoid arthritis 114.42 17.97 850 177138 298763 110112548
Pulmonary fibrosis 114.28 17.97 393 177595 101649 110309662
Grip strength 114.13 17.97 104 177884 9037 110402274
Mucosal inflammation 112.11 17.97 12 177976 96129 110315182
Methaemoglobinaemia 111.92 17.97 103 177885 9065 110402246
Anti-cyclic citrullinated peptide antibody 111.75 17.97 149 177839 19815 110391496
C-reactive protein 111.68 17.97 186 177802 30145 110381166
Respiratory failure 111.64 17.97 109 177879 215223 110196088
Swelling 111.18 17.97 954 177034 350087 110061224
Drug reaction with eosinophilia and systemic symptoms 107.62 17.97 6 177982 82089 110329222
Laryngitis 106.97 17.97 221 177767 42190 110369121
Injection site erythema 106.70 17.97 13 177975 94163 110317148
Rash maculo-papular 105.44 17.97 3 177985 74219 110337092
Prescribed overdose 103.99 17.97 344 177644 87237 110324074
Agitation 103.57 17.97 408 177580 112643 110298668
Lung disorder 102.92 17.97 566 177422 179481 110231830
Myocardial infarction 102.18 17.97 95 177893 191988 110219323
Ulcer haemorrhage 101.93 17.97 152 177836 22419 110388892
Vision blurred 101.85 17.97 40 177948 128982 110282329
Pain 99.10 17.97 1021 176967 953934 109457377
Diabetes mellitus 98.42 17.97 20 177968 99361 110311950
Cataract 97.79 17.97 8 177980 79477 110331834
Arthralgia 97.56 17.97 795 177193 778837 109632474
Dyspnoea exertional 96.91 17.97 24 177964 104036 110307275
Leukopenia 96.52 17.97 60 177928 148731 110262580
Pneumonitis 96.14 17.97 7 177981 76524 110334787
Thrombosis 95.65 17.97 28 177960 108634 110302677
Nasal congestion 94.83 17.97 21 177967 98261 110313050
Musculoskeletal pain 94.53 17.97 560 177428 182463 110228848
Osteoarthritis 94.46 17.97 559 177429 182064 110229247
Memory impairment 94.38 17.97 591 177397 196353 110214958
Haemoptysis 94.20 17.97 5 177983 71349 110339962
Rhinorrhoea 93.08 17.97 25 177963 102641 110308670
Weight decreased 92.41 17.97 413 177575 467644 109943667
Influenza like illness 91.38 17.97 16 177972 88396 110322915
Hypothyroidism 90.63 17.97 7 177981 72892 110338419
Abdominal pain 90.62 17.97 471 177517 512518 109898793
Hyperkalaemia 90.55 17.97 53 177935 135743 110275568
Bronchitis 89.17 17.97 73 177915 156959 110254352
Dysgeusia 89.08 17.97 6 177982 69979 110341332
Blood pressure systolic increased 88.03 17.97 14 177974 82977 110328334
Live birth 87.98 17.97 279 177709 69205 110342106
Nail disorder 87.91 17.97 248 177740 57687 110353624
Blood creatinine increased 86.50 17.97 100 177888 182789 110228522
Pleural effusion 86.41 17.97 95 177893 177614 110233697
Dry skin 85.59 17.97 33 177955 107620 110303691
Plasma cell myeloma 84.39 17.97 4 177984 62932 110348379
Stress 84.25 17.97 32 177956 105316 110305995
Rash erythematous 84.16 17.97 15 177973 81817 110329494
Intentional self-injury 83.98 17.97 186 177802 37243 110374068
Blood glucose increased 83.79 17.97 55 177933 132441 110278870
Environmental exposure 83.23 17.97 29 177959 355 110410956
Agranulocytosis 82.57 17.97 4 177984 61756 110349555
Cardiac failure congestive 82.31 17.97 73 177915 150927 110260384
Gastrointestinal disorder 82.12 17.97 668 177320 241284 110170027
Alcohol withdrawal syndrome 82.12 17.97 48 177940 2082 110409229
Drug abuser 80.49 17.97 68 177920 5341 110405970
Palpitations 78.64 17.97 84 177904 159128 110252183
Neoplasm progression 78.10 17.97 7 177981 64588 110346723
Alcoholism 77.62 17.97 57 177931 3650 110407661
Contusion 77.43 17.97 641 177347 232720 110178591
Subcutaneous drug absorption impaired 76.41 17.97 77 177911 7582 110403729
Skin exfoliation 76.39 17.97 23 177965 87628 110323683
Arthropathy 76.12 17.97 752 177236 286770 110124541
Dysphonia 75.77 17.97 15 177973 75914 110335397
Wheezing 75.76 17.97 684 177304 254546 110156765
Delirium 74.83 17.97 421 177567 134604 110276707
Walking aid user 74.53 17.97 140 177848 24935 110386376
Angioedema 73.78 17.97 33 177955 98467 110312844
Hepatic cirrhosis 73.58 17.97 258 177730 67368 110343943
Eczema 72.74 17.97 14 177974 72279 110339032
Intestinal obstruction 72.63 17.97 3 177985 53224 110358087
Drug screen positive 72.45 17.97 69 177919 6341 110404970
Lymphadenopathy 71.85 17.97 9 177979 63826 110347485
Haemorrhage 70.62 17.97 42 177946 106650 110304661
Haematuria 70.16 17.97 23 177965 82982 110328329
Lymphocyte count decreased 69.76 17.97 6 177982 57237 110354074
Transient ischaemic attack 69.68 17.97 10 177978 63972 110347339
Ascites 69.66 17.97 31 177957 92777 110318534
Injection site pruritus 69.57 17.97 3 177985 51255 110360056
Drug resistance 68.45 17.97 6 177982 56368 110354943
Dizziness 68.45 17.97 756 177232 697437 109713874
Blood pressure fluctuation 68.24 17.97 18 177970 74806 110336505
Confusional state 68.12 17.97 1096 176892 467584 109943727
Heart rate decreased 68.10 17.97 24 177964 82732 110328579
Multiple sclerosis relapse 67.99 17.97 3 177985 50237 110361074
Balance disorder 67.66 17.97 53 177935 116507 110294804
Contraindicated product administered 67.00 17.97 652 177336 247615 110163696
Flushing 66.87 17.97 43 177945 104693 110306618
Bone pain 66.84 17.97 12 177976 65121 110346190
Migraine 66.61 17.97 489 177499 171163 110240148
Injection site swelling 66.50 17.97 10 177978 61780 110349531
Injection site bruising 66.42 17.97 4 177984 51259 110360052
Hypokalaemia 66.34 17.97 120 177868 182328 110228983
Toxic epidermal necrolysis 66.34 17.97 7 177981 56720 110354591
Maternal exposure during pregnancy 66.18 17.97 664 177324 254219 110157092
Drug ineffective for unapproved indication 65.96 17.97 42 177946 102796 110308515
Dyspepsia 65.74 17.97 529 177459 190436 110220875
Hyperhidrosis 65.62 17.97 126 177862 187172 110224139
Tachycardia 65.53 17.97 604 177384 226041 110185270
Postmortem blood drug level abnormal 65.51 17.97 28 177960 612 110410699
Withdrawal syndrome 64.91 17.97 151 177837 31229 110380082
Adverse event 64.81 17.97 346 177642 108463 110302848
Alanine aminotransferase increased 64.06 17.97 124 177864 183649 110227662
Victim of sexual abuse 63.28 17.97 26 177962 513 110410798
Insomnia 62.82 17.97 870 177118 359720 110051591
Fungal infection 62.81 17.97 5 177983 50801 110360510
Condition aggravated 62.74 17.97 820 177168 734016 109677295
Nephrolithiasis 62.18 17.97 15 177973 66197 110345114
Prescribed underdose 61.94 17.97 238 177750 64936 110346375
Hot flush 61.93 17.97 15 177973 66021 110345290
Adverse reaction 61.87 17.97 143 177845 29451 110381860
Swollen joint count 61.73 17.97 73 177915 8601 110402710
Throat irritation 61.63 17.97 7 177981 53545 110357766
Anaphylactic shock 61.22 17.97 6 177982 51540 110359771
Hypocalcaemia 61.01 17.97 15 177973 65351 110345960
Pregnancy 60.98 17.97 201 177787 50866 110360445
Infusion related reaction 60.97 17.97 906 177082 380256 110031055
Eosinophilia 60.94 17.97 10 177978 57926 110353385
Hypoaesthesia 60.90 17.97 773 177215 313450 110097861
Skin ulcer 60.59 17.97 14 177974 63631 110347680
Incorrect dose administered 60.31 17.97 47 177941 103594 110307717
Dry eye 60.11 17.97 9 177979 55784 110355527
Victim of chemical submission 60.01 17.97 29 177959 850 110410461
Back injury 59.70 17.97 190 177798 47209 110364102
Hypercalcaemia 59.38 17.97 4 177984 46653 110364658
Electrocardiogram QRS complex prolonged 59.24 17.97 88 177900 12933 110398378
Diverticulitis 59.15 17.97 8 177980 53514 110357797
Viral infection 58.59 17.97 8 177980 53131 110358180
Blepharospasm 58.58 17.97 208 177780 54643 110356668
Bacterial infection 58.43 17.97 4 177984 46032 110365279
Melaena 58.21 17.97 19 177969 68738 110342573
Hypomagnesaemia 58.03 17.97 13 177975 60357 110350954
Foot deformity 57.16 17.97 190 177798 48290 110363021
Heart rate increased 56.52 17.97 90 177898 143744 110267567
Oral candidiasis 56.49 17.97 4 177984 44756 110366555
Suicidal ideation 56.14 17.97 299 177689 93638 110317673
Swollen tongue 56.05 17.97 14 177974 60348 110350963
Candida infection 55.95 17.97 6 177982 48003 110363308
Oedema 55.94 17.97 550 177438 209426 110201885
Dysuria 55.87 17.97 14 177974 60217 110351094
General symptom 55.73 17.97 70 177918 8776 110402535
Upper respiratory tract infection 55.66 17.97 78 177910 131250 110280061
Finger deformity 55.53 17.97 147 177841 32945 110378366
Acute myocardial infarction 55.42 17.97 33 177955 83744 110327567
Bradypnoea 55.38 17.97 69 177919 8580 110402731
Illness 54.87 17.97 32 177956 82139 110329172
Disease recurrence 54.72 17.97 15 177973 60769 110350542
Haematocrit decreased 54.70 17.97 19 177969 66098 110345213
Blood ethanol 54.48 17.97 16 177972 107 110411204
Mouth ulceration 53.66 17.97 7 177981 48131 110363180
Pain in jaw 53.46 17.97 9 177979 51168 110360143
Cardiac disorder 53.41 17.97 28 177960 76252 110335059
Therapeutic product effect decreased 52.98 17.97 614 177374 243702 110167609
Lymphopenia 52.45 17.97 3 177985 40167 110371144
Drug tolerance decreased 52.09 17.97 128 177860 27412 110383899
Upper gastrointestinal haemorrhage 51.91 17.97 9 177979 50087 110361224
Stevens-Johnson syndrome 51.85 17.97 7 177981 46894 110364417
Neuralgia 51.82 17.97 8 177980 48470 110362841
Therapy interrupted 51.52 17.97 9 177979 49813 110361498
Hypophagia 51.26 17.97 11 177977 52615 110358696
Red blood cell count decreased 51.10 17.97 21 177967 65902 110345409
Hip arthroplasty 50.75 17.97 201 177787 55612 110355699
Sinusitis 50.11 17.97 712 177276 295976 110115335
Multiple organ dysfunction syndrome 48.94 17.97 107 177881 151603 110259708
Orthostatic hypotension 48.37 17.97 23 177965 66226 110345085
Oral pain 48.27 17.97 3 177985 37441 110373870
Homicide 48.20 17.97 27 177961 1079 110410232
Pulmonary mass 48.05 17.97 3 177985 37298 110374013
Limb discomfort 47.88 17.97 5 177983 40849 110370462
Depressed level of consciousness 47.71 17.97 327 177661 111951 110299360
Respiratory tract infection 47.67 17.97 28 177960 71589 110339722
Bacteraemia 47.65 17.97 6 177982 42384 110368927
Burning sensation 47.59 17.97 26 177962 69186 110342125
Tinnitus 47.39 17.97 19 177969 60521 110350790
Vertigo 47.33 17.97 42 177946 86828 110324483
Clostridium difficile colitis 47.31 17.97 7 177981 43771 110367540
Diplopia 46.92 17.97 6 177982 41888 110369423
Product label confusion 46.77 17.97 109 177879 22568 110388743
Chronic kidney disease 46.45 17.97 33 177955 76258 110335053
Haematoma 46.36 17.97 18 177970 58458 110352853
Ulcer 46.35 17.97 7 177981 43109 110368202
Ischaemic stroke 46.00 17.97 6 177982 41257 110370054
Blood pressure diastolic decreased 45.89 17.97 3 177985 35882 110375429
Vasculitis 45.87 17.97 3 177985 35870 110375441
Alopecia 45.71 17.97 833 177155 363920 110047391
Staphylococcal infection 45.63 17.97 28 177960 69916 110341395
Myelodysplastic syndrome 45.48 17.97 4 177984 37480 110373831
Hepatic function abnormal 45.34 17.97 46 177942 89249 110322062
Abdominal pain lower 45.18 17.97 4 177984 37279 110374032
Aspartate aminotransferase increased 45.12 17.97 121 177867 159815 110251496
Cholestasis 44.70 17.97 24 177964 64494 110346817
Rash macular 44.66 17.97 5 177983 38681 110372630
Skin lesion 44.18 17.97 14 177974 51617 110359694
Blood alkaline phosphatase increased 44.09 17.97 30 177958 70905 110340406
Localised infection 44.02 17.97 8 177980 43040 110368271
Urinary retention 43.95 17.97 29 177959 69654 110341657
Angina pectoris 43.42 17.97 23 177965 62272 110349039
Flatulence 43.12 17.97 15 177973 52134 110359177
Hyperglycaemia 43.01 17.97 44 177944 85046 110326265
Pustular psoriasis 43.00 17.97 78 177910 13527 110397784
Postmortem blood drug level 42.96 17.97 17 177971 303 110411008
Oxygen saturation decreased 42.62 17.97 121 177867 156861 110254450
Tubulointerstitial nephritis 42.55 17.97 17 177971 54267 110357044
Cerebral haemorrhage 42.40 17.97 26 177962 64942 110346369
Neoplasm malignant 42.38 17.97 5 177983 37138 110374173
Metastases to liver 42.34 17.97 4 177984 35382 110375929
Breast cancer stage II 42.32 17.97 118 177870 27257 110384054
Unresponsive to stimuli 41.56 17.97 208 177780 63582 110347729
Bronchiectasis 41.42 17.97 5 177983 36488 110374823
Tremor 41.34 17.97 176 177812 202056 110209255
Ear infection 41.19 17.97 205 177783 62527 110348784
Lip swelling 41.16 17.97 15 177973 50652 110360659
Opiates positive 41.13 17.97 23 177965 916 110410395
Sinus disorder 41.08 17.97 3 177985 32725 110378586
Pulmonary arterial hypertension 40.84 17.97 3 177985 32565 110378746
Limb injury 40.71 17.97 6 177982 37630 110373681
Alcohol intolerance 40.67 17.97 18 177970 429 110410882
Urticaria 40.58 17.97 730 177258 318127 110093184
Diabetic ketoacidosis 40.54 17.97 9 177979 42049 110369262
Polyneuropathy 40.00 17.97 3 177985 32009 110379302
COVID-19 pneumonia 39.99 17.97 6 177982 37137 110374174
Skin disorder 39.75 17.97 10 177978 42903 110368408
Hypoacusis 39.51 17.97 5 177983 35186 110376125
Dementia 39.48 17.97 3 177985 31670 110379641
Hypersensitivity 39.45 17.97 889 177099 403109 110008202
Bradycardia 39.25 17.97 124 177864 155393 110255918
Basal cell carcinoma 39.23 17.97 12 177976 45258 110366053
Cholelithiasis 39.18 17.97 27 177961 63395 110347916
Behavioural addiction 39.05 17.97 11 177977 62 110411249
Toxicologic test abnormal 38.99 17.97 25 177963 1282 110410029
Rash vesicular 38.90 17.97 78 177910 14574 110396737
Pain in extremity 38.47 17.97 552 177436 486566 109924745
Respiratory tract congestion 38.25 17.97 3 177985 30854 110380457
Tumour lysis syndrome 38.16 17.97 3 177985 30798 110380513
Analgesic drug level increased 38.14 17.97 39 177949 3907 110407404
Urosepsis 37.97 17.97 3 177985 30672 110380639
Swelling face 37.97 17.97 56 177932 92265 110319046
Procedural pain 37.72 17.97 6 177982 35559 110375752
Breast cancer 37.65 17.97 8 177980 38534 110372777
Therapy cessation 36.92 17.97 13 177975 44844 110366467
Amphetamines positive 36.88 17.97 15 177973 288 110411023
Iron deficiency anaemia 36.63 17.97 4 177984 31555 110379756
Renal disorder 36.39 17.97 17 177971 49462 110361849
Injection site haemorrhage 36.34 17.97 5 177983 33023 110378288
Therapeutic response shortened 36.33 17.97 3 177985 29580 110381731
Coronary artery disease 36.32 17.97 37 177951 71653 110339658
Joint dislocation 35.95 17.97 129 177859 34061 110377250
Nodule 35.77 17.97 5 177983 32626 110378685
Joint injury 35.76 17.97 10 177978 39984 110371327
Therapy partial responder 35.58 17.97 8 177980 37053 110374258
Jaundice 35.57 17.97 26 177962 59210 110352101
Gastric ulcer 35.53 17.97 10 177978 39817 110371494
Feeling cold 35.45 17.97 6 177982 33981 110377330
Faeces discoloured 35.39 17.97 6 177982 33942 110377369
Eye disorder 35.30 17.97 3 177985 28903 110382408
Obstructive airways disorder 35.29 17.97 15 177973 46134 110365177
Accidental overdose 35.18 17.97 171 177817 51663 110359648
Device related infection 35.11 17.97 10 177978 39509 110371802
Hip fracture 34.95 17.97 7 177981 35144 110376167
Hepatocellular injury 34.85 17.97 19 177969 50623 110360688
Gastric disorder 34.54 17.97 6 177982 33351 110377960
Gastritis 34.34 17.97 22 177966 53677 110357634
Rash 34.26 17.97 1033 176955 819931 109591380
Oral herpes 34.22 17.97 8 177980 36072 110375239
Dysstasia 34.01 17.97 6 177982 32980 110378331
Aphasia 34.01 17.97 27 177961 58970 110352341
Diabetes mellitus inadequate control 33.99 17.97 4 177984 29771 110381540
Heart rate irregular 33.72 17.97 7 177981 34267 110377044
Eye pruritus 33.71 17.97 6 177982 32769 110378542
International normalised ratio increased 33.42 17.97 55 177933 86717 110324594
Blood pressure decreased 33.28 17.97 86 177902 115005 110296306
Thrombotic microangiopathy 33.07 17.97 4 177984 29145 110382166
Rib fracture 33.01 17.97 7 177981 33763 110377548
Osteomyelitis 33.00 17.97 9 177979 36591 110374720
Small intestinal obstruction 32.91 17.97 6 177982 32207 110379104
Premature delivery 32.86 17.97 5 177983 30627 110380684
Eye pain 32.76 17.97 20 177968 50079 110361232
Gastroenteritis 32.35 17.97 11 177977 38789 110372522
Disability 31.75 17.97 114 177874 30109 110381202
Abortion spontaneous 31.73 17.97 8 177980 34274 110377037
Pneumonia bacterial 31.33 17.97 3 177985 26258 110385053
Wrong technique in product usage process 31.25 17.97 58 177930 87290 110324021
Tooth disorder 31.24 17.97 5 177983 29504 110381807
Posterior reversible encephalopathy syndrome 31.15 17.97 8 177980 33853 110377458
Hyperthyroidism 30.89 17.97 5 177983 29256 110382055
Brain death 30.73 17.97 45 177943 6528 110404783
Knee arthroplasty 30.52 17.97 194 177794 64754 110346557
Hypophosphataemia 30.22 17.97 8 177980 33174 110378137
Blood lactate dehydrogenase increased 29.98 17.97 17 177971 44317 110366994
Musculoskeletal stiffness 29.93 17.97 624 177364 279198 110132113
Blood test abnormal 29.87 17.97 5 177983 28549 110382762
Appendicitis 29.74 17.97 5 177983 28459 110382852
Cerebral infarction 29.54 17.97 24 177964 51814 110359497
Altered state of consciousness 29.51 17.97 176 177812 57450 110353861
Gastroenteritis viral 29.46 17.97 7 177981 31219 110380092
Blood urea increased 29.42 17.97 27 177961 54930 110356381
Gout 29.41 17.97 11 177977 36555 110374756
Conjunctivitis 29.20 17.97 9 177979 33783 110377528
Movement disorder 29.20 17.97 11 177977 36393 110374918
Pulmonary oedema 28.94 17.97 268 177720 100391 110310920
Lung infiltration 28.90 17.97 3 177985 24625 110386686
Cognitive disorder 28.82 17.97 61 177927 87450 110323861
Neurotoxicity 28.80 17.97 16 177972 42191 110369120
Poor venous access 28.74 17.97 3 177985 24519 110386792
Mitral valve incompetence 28.58 17.97 9 177979 33320 110377991
Pulmonary hypertension 28.54 17.97 28 177960 55192 110356119
Blood potassium decreased 28.48 17.97 27 177961 54087 110357224
Blood bilirubin increased 28.48 17.97 49 177939 75923 110335388
Blood calcium decreased 28.47 17.97 11 177977 35834 110375477
Back disorder 28.32 17.97 86 177902 20836 110390475
Hypothermia 28.30 17.97 100 177888 26202 110385109
Cholecystitis 28.29 17.97 4 177984 25878 110385433
Neuroleptic malignant syndrome 27.81 17.97 10 177978 34049 110377262
Subdural haematoma 27.63 17.97 12 177976 36442 110374869
Laboratory test abnormal 27.50 17.97 142 177846 43937 110367374
Frequent bowel movements 27.46 17.97 203 177785 71187 110340124
Pancreatitis acute 27.37 17.97 34 177954 60240 110351071
Paraesthesia oral 27.30 17.97 10 177978 33661 110377650
Vaginal haemorrhage 27.11 17.97 4 177984 25070 110386241
Injection site rash 27.10 17.97 3 177985 23416 110387895
Acne 27.10 17.97 10 177978 33510 110377801
Urinary incontinence 27.06 17.97 23 177965 48564 110362747
Drug-induced liver injury 27.01 17.97 304 177684 119763 110291548
Petechiae 26.95 17.97 3 177985 23314 110387997
Epilepsy 26.92 17.97 263 177725 99946 110311365
Drug withdrawal syndrome 26.88 17.97 127 177861 37927 110373384
Normal newborn 26.87 17.97 87 177901 21809 110389502
Infection 26.78 17.97 768 177220 361432 110049879
Metastases to lung 26.58 17.97 3 177985 23060 110388251
Pallor 26.55 17.97 31 177957 56436 110354875
Delirium tremens 26.54 17.97 16 177972 735 110410576
Eye injury 26.49 17.97 46 177942 7709 110403602
Malaise 26.38 17.97 852 177136 670967 109740344
Hypoalbuminaemia 26.36 17.97 7 177981 28967 110382344
Weight fluctuation 26.29 17.97 87 177901 22058 110389253
Skin fissures 26.22 17.97 4 177984 24454 110386857
Metastases to central nervous system 26.21 17.97 3 177985 22814 110388497
Presyncope 26.19 17.97 24 177964 48863 110362448
Pneumothorax 26.14 17.97 12 177976 35273 110376038
Impaired driving ability 26.08 17.97 41 177947 6329 110404982
Oesophagitis 26.01 17.97 7 177981 28708 110382603
Blindness 25.97 17.97 13 177975 36346 110374965
Impaired quality of life 25.93 17.97 8 177980 30009 110381302
Carpal tunnel syndrome 25.91 17.97 3 177985 22607 110388704
Multiple sclerosis 25.80 17.97 5 177983 25693 110385618
Immune thrombocytopenia 25.73 17.97 3 177985 22491 110388820
Kidney infection 25.66 17.97 5 177983 25594 110385717
Foot fracture 25.58 17.97 5 177983 25541 110385770
Myocardial fibrosis 25.50 17.97 23 177965 1972 110409339
Product prescribing error 25.43 17.97 27 177961 51304 110360007
Hemiparesis 25.42 17.97 20 177968 43883 110367428
Visual acuity reduced 25.34 17.97 10 177978 32163 110379148
Physical assault 25.33 17.97 21 177967 1607 110409704
Weight increased 25.28 17.97 868 177120 418776 109992535
Joint swelling 24.94 17.97 909 177079 441936 109969375
Vomiting 24.89 17.97 1205 176783 909470 109501841
Accidental poisoning 24.80 17.97 25 177963 2462 110408849
Impaired work ability 24.78 17.97 6 177982 26413 110384898
Myopathy 24.76 17.97 5 177983 24955 110386356
Somnolence 24.62 17.97 640 177348 296809 110114502
Macular degeneration 24.50 17.97 3 177985 21656 110389655
Acute respiratory failure 24.33 17.97 53 177935 75207 110336104
Red blood cell sedimentation rate increased 24.31 17.97 212 177776 78090 110333221
Abdominal discomfort 24.31 17.97 817 177171 393041 110018270
Colitis ulcerative 24.30 17.97 210 177778 77153 110334158
Peritonitis 24.30 17.97 11 177977 32596 110378715
Skin necrosis 24.29 17.97 3 177985 21509 110389802
Product substitution issue 24.21 17.97 4 177984 23057 110388254
Sleep disorder due to a general medical condition 24.08 17.97 155 177833 51957 110359354
Skin discolouration 24.07 17.97 26 177962 49020 110362291
Taste disorder 24.06 17.97 184 177804 65203 110346108
Muscle spasms 24.05 17.97 602 177386 277555 110133756
Electrolyte imbalance 23.91 17.97 15 177973 37013 110374298
Throat tightness 23.88 17.97 12 177976 33477 110377834
Bone disorder 23.82 17.97 3 177985 21189 110390122
Blood urine present 23.75 17.97 5 177983 24240 110387071
Erythema multiforme 23.68 17.97 3 177985 21094 110390217
Eating disorder 23.64 17.97 10 177978 30848 110380463
Intestinal perforation 23.45 17.97 3 177985 20941 110390370
Sedation 23.43 17.97 48 177940 69635 110341676
Haemolytic anaemia 23.42 17.97 3 177985 20917 110390394
Unevaluable event 23.32 17.97 37 177951 59190 110352121
Hydronephrosis 23.05 17.97 3 177985 20662 110390649
Brain oedema 22.86 17.97 105 177883 30993 110380318
Product label on wrong product 22.85 17.97 7 177981 55 110411256
Behaviour disorder 22.84 17.97 49 177939 9598 110401713
Rash pruritic 22.82 17.97 81 177907 97988 110313323
Toothache 22.81 17.97 5 177983 23570 110387741
Hiatus hernia 22.72 17.97 8 177980 27598 110383713
Musculoskeletal chest pain 22.67 17.97 9 177979 28838 110382473
Gamma-glutamyltransferase increased 22.57 17.97 40 177948 61269 110350042
Abscess 22.54 17.97 8 177980 27461 110383850
Body temperature decreased 22.45 17.97 16 177972 36919 110374392
Surgery 22.44 17.97 20 177968 41263 110370048
Protein C increased 22.42 17.97 7 177981 59 110411252
Cardiac murmur 22.31 17.97 6 177982 24622 110386689
Exposure via inhalation 22.25 17.97 8 177980 108 110411203
Lacrimation increased 22.20 17.97 11 177977 30939 110380372
Red blood cell sedimentation rate abnormal 22.15 17.97 6 177982 24503 110386808
Immunodeficiency 22.11 17.97 18 177970 38820 110372491
Klebsiella infection 22.09 17.97 3 177985 20006 110391305
Supraventricular tachycardia 22.03 17.97 6 177982 24416 110386895
Pupil fixed 22.03 17.97 29 177959 3809 110407502
Food allergy 22.00 17.97 3 177985 19945 110391366
Eye swelling 21.88 17.97 13 177975 33035 110378276
Hyperbilirubinaemia 21.85 17.97 11 177977 30660 110380651
Feeding disorder 21.78 17.97 4 177984 21358 110389953
Substance abuser 21.76 17.97 12 177976 465 110410846
Metabolic acidosis 21.74 17.97 251 177737 99493 110311818
Chromaturia 21.73 17.97 10 177978 29350 110381961
Postmortem blood drug level increased 21.70 17.97 17 177971 1200 110410111
Poor quality sleep 21.67 17.97 9 177979 28068 110383243
Ageusia 21.56 17.97 3 177985 19642 110391669
Blood sodium decreased 21.51 17.97 18 177970 38301 110373010
Spinal fracture 21.50 17.97 5 177983 22628 110388683
Muscle rigidity 21.50 17.97 6 177982 24025 110387286
Glaucoma 21.34 17.97 5 177983 22512 110388799
Adrenal insufficiency 21.33 17.97 22 177966 42368 110368943
Skin infection 21.33 17.97 5 177983 22504 110388807
Bronchospasm 21.31 17.97 11 177977 30228 110381083
Tricuspid valve incompetence 21.28 17.97 6 177982 23867 110387444
Glomerular filtration rate decreased 21.22 17.97 10 177978 28946 110382365
Intervertebral disc protrusion 21.18 17.97 9 177979 27689 110383622
Liver function test abnormal 21.12 17.97 50 177938 68900 110342411
Upper limb fracture 21.11 17.97 4 177984 20884 110390427
Hepatic cytolysis 21.10 17.97 35 177953 55018 110356293
Substance use 21.08 17.97 23 177965 2483 110408828
Blood iron decreased 20.93 17.97 3 177985 19211 110392100
Osteopenia 20.91 17.97 5 177983 22204 110389107
Hypotension 20.87 17.97 663 177325 523186 109888125
Enteritis 20.84 17.97 3 177985 19153 110392158
Psoriasis 20.68 17.97 136 177852 139857 110271454
Injection site mass 20.48 17.97 7 177981 24606 110386705
Drug interaction 20.42 17.97 631 177357 499552 109911759
Dyskinesia 20.39 17.97 32 177956 51414 110359897
Hepatitis C virus test positive 20.34 17.97 11 177977 410 110410901
Tooth abscess 20.31 17.97 3 177985 18786 110392525
Blood uric acid increased 19.97 17.97 5 177983 21524 110389787
Myasthenia gravis 19.95 17.97 5 177983 21506 110389805
Hyperlipidaemia 19.93 17.97 17 177971 35831 110375480
Alcoholic coma 19.92 17.97 7 177981 88 110411223
End stage renal disease 19.90 17.97 5 177983 21468 110389843
Pain of skin 19.89 17.97 4 177984 20025 110391286
Breath sounds abnormal 19.84 17.97 8 177980 25396 110385915
Squamous cell carcinoma 19.84 17.97 3 177985 18460 110392851
Haemorrhage intracranial 19.74 17.97 11 177977 28958 110382353
Atelectasis 19.70 17.97 18 177970 36694 110374617
Eye irritation 19.67 17.97 15 177973 33437 110377874
Coeliac disease 19.67 17.97 128 177860 43059 110368252
Gingival bleeding 19.62 17.97 4 177984 19835 110391476
Blood albumin decreased 19.58 17.97 10 177978 27642 110383669
Decubitus ulcer 19.51 17.97 3 177985 18233 110393078
Substance dependence 19.51 17.97 13 177975 712 110410599
Nephropathy toxic 19.36 17.97 10 177978 27468 110383843
Housebound 19.36 17.97 11 177977 452 110410859
Intervertebral disc degeneration 19.29 17.97 3 177985 18082 110393229
Coma scale abnormal 19.24 17.97 46 177942 9680 110401631
Sleep apnoea syndrome 19.24 17.97 22 177966 40425 110370886
Duodenal ulcer 19.17 17.97 4 177984 19510 110391801
Areflexia 19.14 17.97 37 177951 6732 110404579
Exposure during pregnancy 19.10 17.97 377 177611 167047 110244264
Ocular hyperaemia 19.09 17.97 21 177967 39265 110372046
Fracture 19.04 17.97 8 177980 24780 110386531
Leukocytosis 19.03 17.97 36 177952 53792 110357519
Pollakiuria 18.97 17.97 26 177962 44169 110367142
Proteinuria 18.78 17.97 22 177966 39996 110371315
Photophobia 18.73 17.97 9 177979 25762 110385549
Red cell distribution width increased 18.60 17.97 3 177985 17599 110393712
Alcoholic 18.59 17.97 5 177983 23 110411288
Photosensitivity reaction 18.50 17.97 9 177979 25580 110385731
Deafness 18.41 17.97 10 177978 26699 110384612
Staphylococcal sepsis 18.38 17.97 3 177985 17451 110393860
C-reactive protein increased 18.35 17.97 470 177518 217449 110193862
Adulterated product 18.18 17.97 15 177973 1140 110410171
Sensory loss 18.04 17.97 6 177982 21451 110389860
Complication associated with device 17.98 17.97 5 177983 20068 110391243

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AX08 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Other antiseptics and disinfectants
ATC V03AB16 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
ATC V03AZ01 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Nerve depressants
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D012997 Solvents
CHEBI has role CHEBI:35488 central nervous system depressant
CHEBI has role CHEBI:48218 antiseptic drug
CHEBI has role CHEBI:48219 disinfectant
CHEBI has role CHEBI:48354 polar solvent
CHEBI has role CHEBI:50905 teratogenic agent
CHEBI has role CHEBI:50910 neurotoxin
CHEBI has role CHEBI:60643 NMDA receptor antagonist
CHEBI has role CHEBI:64018 protein kinase C agonist
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:75772 <em>Saccharomyces cerevisiae </em> metabolite
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite
CHEBI has role CHEBI:77746 human metabolite

Related Drugs by ATC class:

D08AX Other antiseptics and disinfectants 7 drugs
eosinhydrogen peroxideisopropanolpotassium permanganatepropanolsodium hypochloritetosylchloramide sodium
V03AB Antidotes 28 drugs
4-dimethylaminophenolacetylcysteineamyl nitriteandexanet alfaatropinecopper sulfatedimercaprolflumazenilfomepizoleglutathionehydroxocobalaminidarucizumab show all 28 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Antiseptic preparation indication 261276004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glutamate receptor ionotropic, NMDA 3A Ion channel WOMBAT-PK
Glycine receptor subunit alpha-1 Ion channel WOMBAT-PK
Glycine receptor subunit alpha-2 Ion channel WOMBAT-PK
GABA A receptor alpha-4/beta-2/delta Ion channel WOMBAT-PK

External reference:

IDSource
4017736 VUID
N0000146104 NUI
D06542 KEGG_DRUG
4017424 VANDF
4017736 VANDF
C0001962 UMLSCUI
CHEBI:16236 CHEBI
EOH PDB_CHEM_ID
CHEMBL545 ChEMBL_ID
702 PUBCHEM_CID
DB00898 DRUGBANK_ID
D000431 MESH_DESCRIPTOR_UI
2299 IUPHAR_LIGAND_ID
448 RXNORM
10010 MMSL
4693 MMSL
9888 MMSL
d03162 MMSL
001539 NDDF
002464 NDDF
398624005 SNOMEDCT_US
419442005 SNOMEDCT_US
3K9958V90M UNII
3K9958V90M INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TRISEPTINHAND AND BODY ANTISEPTIC HUMAN OTC DRUG LABEL 1 0064-1050 LOTION 0.70 mL TOPICAL OTC monograph not final 9 sections
SURGICEPT Waterless, Surgical Handscrub and Healthcare Personnel Handwash HUMAN OTC DRUG LABEL 1 0064-1080 SOLUTION 0.75 mL TOPICAL OTC monograph not final 10 sections
SeptoSan Hand Sanitizer HUMAN OTC DRUG LABEL 1 0362-6000 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
SeptoSan Hand Sanitizer HUMAN OTC DRUG LABEL 1 0362-6001 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
SeptoSan Hand Sanitizer HUMAN OTC DRUG LABEL 1 0362-6002 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
Alcohol HUMAN OTC DRUG LABEL 1 0363-0046 LIQUID 62 mL TOPICAL OTC Monograph Drug 12 sections
Crisp Apple Hand Sani HUMAN OTC DRUG LABEL 1 0363-0663 LIQUID 585 g TOPICAL OTC monograph not final 13 sections
Walgreens HUMAN OTC DRUG LABEL 1 0363-0859 GEL 700 mg TOPICAL OTC Monograph Drug 11 sections
Ethyl Rubbing Alcohol HUMAN OTC DRUG LABEL 1 0363-0876 LIQUID 70 mL TOPICAL OTC Monograph Drug 14 sections
A Little Something Eucalyptus Mist Hand Sanitier HUMAN OTC DRUG LABEL 1 0363-1050 LIQUID 700 mg TOPICAL OTC monograph not final 1 sections
A Little Something Eucalyptus Mist Hand Sanitier HUMAN OTC DRUG LABEL 1 0363-1050 LIQUID 700 mg TOPICAL OTC monograph not final 1 sections
A Little Something Prosecco Bubbles Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-1051 LIQUID 700 mg TOPICAL OTC monograph not final 1 sections
A Little Something Prosecco Bubbles Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-1051 LIQUID 700 mg TOPICAL OTC monograph not final 1 sections
Walgreens HUMAN OTC DRUG LABEL 1 0363-1233 GEL 700 mg TOPICAL OTC Monograph Drug 11 sections
Walgreens WATERMELON Hand Sanitizer Mist HUMAN OTC DRUG LABEL 1 0363-5190 SPRAY 70 mL TOPICAL OTC Monograph Drug 10 sections
Walgreens PEAR Hand Sanitizer Mist HUMAN OTC DRUG LABEL 1 0363-5191 SPRAY 70 mL TOPICAL OTC Monograph Drug 11 sections
Walgreens SWEET PEA PETALS Hand Sanitizer Mist HUMAN OTC DRUG LABEL 1 0363-5192 SPRAY 70 mL TOPICAL OTC Monograph Drug 11 sections
Walgreens WATERMELON Hand Sanitizer Mist HUMAN OTC DRUG LABEL 1 0363-5193 SPRAY 70 mL TOPICAL OTC Monograph Drug 11 sections
Walgreens VANILLA Hand Sanitizer Mist HUMAN OTC DRUG LABEL 1 0363-5199 SPRAY 70 mL TOPICAL OTC Monograph Drug 11 sections
Walgreens HUMAN OTC DRUG LABEL 1 0363-5721 GEL 700 mg TOPICAL OTC Monograph Drug 10 sections
Walgreens HUMAN OTC DRUG LABEL 1 0363-5721 GEL 700 mg TOPICAL OTC Monograph Drug 10 sections
Walgreens HUMAN OTC DRUG LABEL 1 0363-5721 GEL 700 mg TOPICAL OTC Monograph Drug 10 sections
Walgreens Advanced Hand Sanitizer with Aloe and Vitamin E HUMAN OTC DRUG LABEL 1 0363-9003 GEL 69 mL TOPICAL OTC monograph not final 12 sections
Walgreens Advanced Hand Sanitizer with Vitamin E HUMAN OTC DRUG LABEL 1 0363-9004 GEL 69 mL TOPICAL OTC monograph not final 12 sections
Walgreens Advanced Hand Sanitizer Made with Plant-Based Ethyl Alcohol HUMAN OTC DRUG LABEL 1 0363-9005 GEL 69 mL TOPICAL OTC monograph not final 12 sections
Walgreens Hand Sanitizer Coastal Breeze Scent HUMAN OTC DRUG LABEL 1 0363-9006 GEL 69 mL TOPICAL OTC monograph not final 12 sections
Walgreens Hand Sanitizer Crisp Apple Scent HUMAN OTC DRUG LABEL 1 0363-9007 GEL 69 mL TOPICAL OTC monograph not final 12 sections
Walgreens Advanced Hand Sanitizer with Vitamin E HUMAN OTC DRUG LABEL 1 0363-9008 GEL 69 mL TOPICAL OTC monograph not final 13 sections
WALGREENS INSTANT HAND SANITIZER HUMAN OTC DRUG LABEL 1 0363-9320 SPRAY 62 mL TOPICAL OTC monograph not final 11 sections
Ethyl Rubbing Alcohol HUMAN OTC DRUG LABEL 1 0395-0040 LIQUID 700 mg TOPICAL OTC Monograph Drug 13 sections