ethanol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1076	64-17-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: alcohol ethanol ethyl alcohol grain alcohol	A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. Molecular weight: 46.07 Formula: C2H6O CLOGP: -0.24 LIPINSKI: 0 HAC: 1 HDO: 1 TPSA: 20.23 ALOGS: 1.10 ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

alcohol
ethanol
ethyl alcohol
grain alcohol

A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.

Molecular weight: 46.07
Formula: C2H6O
CLOGP: -0.24
LIPINSKI: 0
HAC: 1
HDO: 1
TPSA: 20.23
ALOGS: 1.10
ROTB: 0

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	2.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	2170.63 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	80 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Jan. 17, 1946	FDA	B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	8405.24	19.13	3086	27917	135115	53182948
Toxicity to various agents	4747.35	19.13	2364	28639	217234	53100829
Drug abuse	2744.90	19.13	1126	29877	64400	53253663
Cardio-respiratory arrest	1694.09	19.13	777	30226	57981	53260082
Intentional overdose	1525.53	19.13	754	30249	66451	53251612
Respiratory arrest	1145.56	19.13	500	30503	33040	53285023
Overdose	1095.83	19.13	715	30288	107021	53211042
Cardiac arrest	879.96	19.13	592	30411	93075	53224988
Suicide attempt	873.53	19.13	496	30507	57672	53260391
Poisoning	835.02	19.13	311	30692	13539	53304524
Intentional product misuse	735.45	19.13	419	30584	48973	53269090
Death	589.93	19.13	869	30134	356363	52961700
Alcohol interaction	537.69	19.13	139	30864	1718	53316345
Drug hypersensitivity	521.31	19.13	702	30301	264540	53053523
Alcohol poisoning	445.90	19.13	120	30883	1749	53316314
Alcohol use	443.69	19.13	122	30881	1936	53316127
Exposure via ingestion	339.02	19.13	110	30893	3145	53314918
Alcohol abuse	265.74	19.13	82	30921	1982	53316081
Coma	252.53	19.13	240	30763	61543	53256520
Suspected suicide	230.24	19.13	89	30914	4279	53313784
Poisoning deliberate	188.72	19.13	95	30908	8618	53309445
Somnolence	176.96	19.13	335	30668	167399	53150664
Blood alcohol increased	165.20	19.13	43	30960	546	53317517
Diarrhoea	160.71	19.13	82	30921	625464	52692599
Drug ineffective	126.68	19.13	175	30828	817070	52500993
Mydriasis	119.04	19.13	77	30926	11249	53306814
Methaemoglobinaemia	118.69	19.13	46	30957	2226	53315837
Fatigue	117.62	19.13	152	30851	730354	52587709
Headache	117.28	19.13	85	30918	536736	52781327
Pneumonia	111.03	19.13	49	30954	407120	52910943
Pain	108.06	19.13	110	30893	588288	52729775
Substance abuse	97.31	19.13	49	30954	4445	53313618
Intentional self-injury	95.25	19.13	94	30909	25190	53292873
Asthenia	94.17	19.13	41	30962	343549	52974514
Dyspnoea	93.14	19.13	123	30880	586109	52731954
Nausea	91.12	19.13	190	30813	755901	52562162
Alcoholism	88.31	19.13	37	30966	2194	53315869
Loss of consciousness	86.16	19.13	199	30804	114013	53204050
Off label use	85.76	19.13	89	30914	472123	52845940
Agitation	83.74	19.13	134	30869	58492	53259571
Anaemia	79.05	19.13	31	30972	276687	53041376
Cough	78.09	19.13	26	30977	256867	53061196
Rheumatoid arthritis	72.25	19.13	47	30956	314484	53003579
Drug abuser	70.09	19.13	35	30968	3118	53314945
Pyrexia	69.81	19.13	79	30924	403114	52914949
Metabolic acidosis	67.93	19.13	102	30901	42140	53275923
Product dose omission issue	66.44	19.13	15	30988	191605	53126458
Accidental death	65.64	19.13	28	30975	1736	53316327
Drug dependence	64.98	19.13	71	30932	21401	53296662
Tachycardia	64.14	19.13	172	30831	108040	53210023
Back pain	64.04	19.13	28	30975	234219	53083844
Rash	63.48	19.13	101	30902	446090	52871973
Malaise	63.06	19.13	69	30934	357548	52960515
Unresponsive to stimuli	62.94	19.13	87	30916	33339	53284724
Liver injury	61.59	19.13	70	30933	22033	53296030
Depressed level of consciousness	61.35	19.13	112	30891	54316	53263747
Urinary tract infection	59.05	19.13	33	30970	239870	53078193
Aggression	58.34	19.13	70	30933	23333	53294730
Postmortem blood drug level abnormal	57.08	19.13	16	30987	273	53317790
Neutropenia	56.10	19.13	12	30991	159173	53158890
Victim of sexual abuse	55.17	19.13	18	30985	523	53317540
Drug use disorder	55.13	19.13	30	30973	3189	53314874
Electrocardiogram QT prolonged	54.85	19.13	109	30894	56294	53261769
Exposure to toxic agent	54.36	19.13	25	30978	1855	53316208
Hepatic failure	54.09	19.13	84	30919	35722	53282341
Dizziness	53.15	19.13	84	30919	372175	52945888
Electrocardiogram QRS complex prolonged	52.98	19.13	36	30967	5706	53312357
Drug withdrawal syndrome	52.85	19.13	73	30930	27949	53290114
Gastrointestinal toxicity	51.58	19.13	33	30970	4729	53313334
Decreased appetite	48.14	19.13	33	30970	214941	53103122
Weight decreased	47.58	19.13	40	30963	234908	53083155
Bronchitis	47.26	19.13	5	30998	111894	53206169
Seizure	47.25	19.13	174	30829	129335	53188728
Constipation	46.40	19.13	29	30974	198383	53119680
Suicidal ideation	46.21	19.13	106	30897	60405	53257658
Arthralgia	45.91	19.13	119	30884	439664	52878399
Disease progression	44.50	19.13	4	30999	101916	53216147
Pain in extremity	43.89	19.13	61	30942	284989	53033074
Cerebrovascular accident	43.65	19.13	5	30998	105169	53212894
Pulmonary toxicity	43.20	19.13	31	30972	5360	53312703
White blood cell count decreased	42.61	19.13	10	30993	124465	53193598
Blood ethanol increased	42.59	19.13	10	30993	80	53317983
Myocarditis	42.58	19.13	37	30966	8431	53309632
Sepsis	42.43	19.13	16	30987	146413	53171650
Cardiac failure congestive	42.28	19.13	3	31000	92754	53225309
Postoperative wound infection	41.65	19.13	38	30965	9228	53308835
Febrile neutropenia	41.12	19.13	6	30997	104930	53213133
Respiratory depression	39.89	19.13	43	30960	12763	53305300
Sinus tachycardia	39.43	19.13	58	30945	23514	53294549
Somnambulism	38.63	19.13	29	30974	5373	53312690
Fall	38.14	19.13	96	30907	358344	52959719
Hepatotoxicity	37.44	19.13	62	30941	27818	53290245
Chest pain	36.54	19.13	34	30969	190151	53127912
Asphyxia	36.35	19.13	29	30974	5872	53312191
Influenza	36.13	19.13	6	30997	95373	53222690
Homicide	35.95	19.13	12	30991	375	53317688
Thrombocytopenia	35.69	19.13	18	30985	138709	53179354
Haemoglobin decreased	35.05	19.13	18	30985	137289	53180774
Pruritus	35.03	19.13	74	30929	293758	53024305
Abdominal pain	34.38	19.13	60	30943	255843	53062220
Pancytopenia	33.82	19.13	6	30997	90922	53227141
Accidental overdose	33.29	19.13	51	30952	21428	53296635
Aspiration	33.06	19.13	35	30968	10175	53307888
Condition aggravated	32.83	19.13	78	30925	297056	53021007
Housebound	32.78	19.13	10	30993	232	53317831
Drug screen positive	32.72	19.13	23	30980	3849	53314214
Pulmonary embolism	32.33	19.13	13	30990	114429	53203634
Blood pressure increased	32.18	19.13	21	30982	140458	53177605
Arthritis	31.96	19.13	6	30997	87292	53230771
Dehydration	31.30	19.13	31	30972	168379	53149684
Weight increased	31.24	19.13	44	30959	204523	53113540
Muscular weakness	31.03	19.13	10	30993	100982	53217081
Acute hepatic failure	30.69	19.13	43	30960	16677	53301386
Neuropathy peripheral	30.35	19.13	11	30992	103176	53214887
Injection site pain	30.25	19.13	14	30989	113377	53204686
Chemical submission	29.96	19.13	9	30994	198	53317865
Platelet count decreased	29.38	19.13	13	30990	108086	53209977
Disinhibition	29.28	19.13	13	30990	888	53317175
Iodine allergy	29.24	19.13	12	30991	675	53317388
Sinusitis	29.12	19.13	33	30970	168531	53149532
Erythema	29.05	19.13	29	30974	156940	53161123
Sopor	28.46	19.13	47	30956	21037	53297026
Mobility decreased	28.44	19.13	5	30998	76266	53241797
Protein C increased	28.14	19.13	8	30995	144	53317919
Environmental exposure	27.65	19.13	7	30996	79	53317984
Victim of chemical submission	27.64	19.13	9	30994	260	53317803
Loss of personal independence in daily activities	27.33	19.13	4	30999	69811	53248252
Herpes zoster	27.28	19.13	5	30998	74014	53244049
Abdominal pain upper	27.18	19.13	34	30969	166257	53151806
Brain oedema	26.59	19.13	36	30967	13522	53304541
Migraine	26.47	19.13	7	30996	80410	53237653
Alopecia	26.36	19.13	61	30942	234522	53083541
Malignant neoplasm progression	26.01	19.13	5	30998	71536	53246527
Oedema peripheral	25.80	19.13	37	30966	170750	53147313
Gastrooesophageal reflux disease	25.72	19.13	8	30995	82655	53235408
Asthma	25.35	19.13	16	30987	108956	53209107
Injection site erythema	24.91	19.13	7	30996	77242	53240821
Medication error	24.82	19.13	61	30942	36304	53281759
Incorrect route of product administration	24.78	19.13	42	30961	19202	53298861
Miosis	24.46	19.13	25	30978	6977	53311086
Induced abortion failed	23.85	19.13	8	30995	254	53317809
Alcohol withdrawal syndrome	23.79	19.13	11	30992	826	53317237
Abdominal discomfort	23.64	19.13	59	30944	221003	53097060
Osteoarthritis	23.46	19.13	6	30997	70480	53247583
Brain death	23.42	19.13	17	30986	2991	53315072
Septic shock	23.37	19.13	4	30999	62225	53255838
Oropharyngeal pain	23.33	19.13	9	30994	81259	53236804
Areflexia	23.28	19.13	17	30986	3019	53315044
Ventricular tachycardia	23.18	19.13	39	30964	17723	53300340
Blood pH decreased	23.11	19.13	16	30987	2614	53315449
Leukopenia	23.06	19.13	7	30996	73456	53244607
Toxicologic test abnormal	22.91	19.13	10	30993	656	53317407
Amnesia	22.90	19.13	68	30935	45220	53272843
Shock	22.82	19.13	45	30958	23094	53294969
Productive cough	22.79	19.13	3	31000	56726	53261337
Visceral congestion	22.40	19.13	8	30995	307	53317756
Substance dependence	22.38	19.13	7	30996	177	53317886
C-reactive protein increased	22.17	19.13	6	30997	67880	53250183
Abnormal behaviour	22.14	19.13	43	30960	21823	53296240
Swelling	22.03	19.13	49	30954	191056	53127007
Hypotension	21.99	19.13	235	30768	253841	53064222
Alcoholic	21.88	19.13	5	30998	35	53318028
Pulmonary congestion	21.78	19.13	36	30967	16120	53301943
Muscle spasms	21.57	19.13	28	30975	134767	53183296
Interstitial lung disease	21.51	19.13	4	30999	58618	53259445
Drug interaction	21.43	19.13	208	30795	219121	53098942
Product administration error	21.39	19.13	42	30961	21489	53296574
Euphoric mood	21.19	19.13	19	30984	4510	53313553
Upper respiratory tract infection	20.95	19.13	7	30996	69090	53248973
Analgesic drug level increased	20.81	19.13	13	30990	1787	53316276
Acute kidney injury	20.54	19.13	77	30926	253791	53064272
Infusion related reaction	20.53	19.13	37	30966	155920	53162143
Drug level increased	20.48	19.13	40	30963	20381	53297682
Hospitalisation	20.16	19.13	8	30995	71004	53247059
Peripheral swelling	19.78	19.13	58	30945	206050	53112013
Cyanosis	19.70	19.13	35	30968	16604	53301459
Ventricular fibrillation	19.45	19.13	29	30974	11896	53306167
Blood methanol increased	19.35	19.13	3	31000	0	53318063

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	6857.18	21.42	2619	27932	77624	32405351
Completed suicide	6103.07	21.42	2506	28045	90011	32392964
Toxicity to various agents	5093.90	21.42	2703	27848	175338	32307637
Cardio-respiratory arrest	1384.54	21.42	780	29771	55209	32427766
Intentional product misuse	1181.10	21.42	606	29945	35445	32447530
Intentional overdose	1152.18	21.42	625	29926	40976	32441999
Poisoning	954.00	21.42	368	30183	10790	32472185
Respiratory arrest	929.06	21.42	480	30071	28428	32454547
Overdose	921.20	21.42	714	29837	86363	32396612
Alcohol abuse	703.64	21.42	232	30319	4240	32478735
Suicide attempt	606.86	21.42	402	30149	37842	32445133
Cardiac arrest	569.10	21.42	569	29982	96207	32386768
Alcohol interaction	514.84	21.42	156	30395	2133	32480842
Alcohol poisoning	474.99	21.42	160	30391	3129	32479846
Exposure via ingestion	463.88	21.42	145	30406	2212	32480763
Substance abuse	406.96	21.42	176	30375	6931	32476044
Death	354.60	21.42	966	29585	381551	32101424
Drug dependence	348.46	21.42	237	30314	23247	32459728
Alcohol use	333.73	21.42	124	30427	3259	32479716
Coma	263.50	21.42	258	30293	42354	32440621
Suspected suicide	255.40	21.42	99	30452	2929	32480046
Poisoning deliberate	230.99	21.42	115	30436	6260	32476715
Asphyxia	229.84	21.42	110	30441	5490	32477485
Blood alcohol increased	208.70	21.42	60	30491	674	32482301
Pneumonia	188.31	21.42	51	30500	355201	32127774
Diarrhoea	183.08	21.42	58	30493	364744	32118231
Aggression	181.68	21.42	204	30347	39185	32443790
Pyrexia	158.43	21.42	52	30499	319916	32163059
Anaemia	156.16	21.42	15	30536	223609	32259366
Drug ineffective	150.93	21.42	87	30464	383390	32099585
Accidental death	148.21	21.42	61	30490	2116	32480859
Dyspnoea	142.62	21.42	82	30469	361963	32121012
Respiratory depression	140.38	21.42	109	30442	13102	32469873
Fatigue	128.99	21.42	86	30465	350615	32132360
Accidental overdose	117.36	21.42	116	30435	19223	32463752
Rash	108.87	21.42	31	30520	209302	32273673
Incorrect route of product administration	103.89	21.42	87	30464	11639	32471336
Neutropenia	100.57	21.42	9	30542	142166	32340809
Intentional self-injury	98.81	21.42	91	30460	13809	32469166
Off label use	92.68	21.42	91	30460	306229	32176746
Alcohol withdrawal syndrome	92.15	21.42	39	30512	1452	32481523
Drug withdrawal syndrome	91.87	21.42	104	30447	20127	32462848
Cough	90.04	21.42	12	30539	138805	32344170
Sepsis	89.32	21.42	20	30531	158814	32324161
Drug abuser	86.25	21.42	52	30499	4132	32478843
Nausea	83.23	21.42	108	30443	320741	32162234
Drug screen positive	83.04	21.42	51	30500	4190	32478785
Asthenia	79.85	21.42	63	30488	235881	32247094
Arthralgia	78.96	21.42	21	30530	148427	32334548
Miosis	77.97	21.42	65	30486	8639	32474336
Febrile neutropenia	75.96	21.42	11	30540	119555	32363420
Alcoholism	75.20	21.42	45	30506	3527	32479448
Intentional product use issue	68.94	21.42	134	30417	42077	32440898
Pain in extremity	68.80	21.42	14	30537	118887	32364088
Suicidal ideation	67.27	21.42	125	30426	37958	32445017
Agitation	66.23	21.42	158	30393	57078	32425897
Product dose omission issue	66.17	21.42	9	30542	102566	32380409
Back pain	62.36	21.42	14	30537	111039	32371936
Pruritus	61.60	21.42	22	30529	128680	32354295
Decreased appetite	60.86	21.42	38	30513	160775	32322200
Alcohol intolerance	60.31	21.42	20	30531	371	32482604
Pancytopenia	58.85	21.42	8	30543	91227	32391748
White blood cell count decreased	58.82	21.42	8	30543	91190	32391785
Malignant neoplasm progression	58.18	21.42	4	30547	78492	32404483
Haemoglobin decreased	58.05	21.42	20	30531	119651	32363324
Sopor	57.81	21.42	63	30488	11686	32471289
Platelet count decreased	57.61	21.42	18	30533	114573	32368402
Mydriasis	57.45	21.42	48	30503	6398	32476577
Pain	57.43	21.42	55	30496	187501	32295474
Road traffic accident	57.25	21.42	76	30475	17305	32465670
Medication error	57.19	21.42	87	30464	22448	32460527
Drug use disorder	57.12	21.42	38	30513	3583	32479392
Oedema peripheral	55.46	21.42	19	30532	114072	32368903
Depressed level of consciousness	55.28	21.42	120	30431	40727	32442248
Environmental exposure	55.18	21.42	17	30534	246	32482729
Dizziness	54.81	21.42	70	30481	209548	32273427
Unresponsive to stimuli	54.33	21.42	95	30456	27514	32455461
Infection	53.31	21.42	8	30543	84707	32398268
Condition aggravated	53.30	21.42	41	30510	155620	32327355
Withdrawal syndrome	52.80	21.42	61	30490	12061	32470914
Thrombocytopenia	52.14	21.42	38	30513	148261	32334714
Cerebrovascular accident	50.26	21.42	10	30541	86310	32396665
Cardiac failure	48.64	21.42	13	30538	91660	32391315
Blood ethanol increased	47.53	21.42	17	30534	399	32482576
Renal impairment	47.02	21.42	14	30537	91958	32391017
Cardiac failure congestive	47.02	21.42	11	30540	84841	32398134
Ex-drug abuser	46.67	21.42	13	30538	129	32482846
Atrial fibrillation	46.35	21.42	26	30525	116678	32366297
Shock	46.18	21.42	82	30469	24032	32458943
Dehydration	45.38	21.42	33	30518	128925	32354050
Headache	44.87	21.42	72	30479	196125	32286850
Chest pain	44.69	21.42	31	30520	124106	32358869
Metabolic acidosis	44.55	21.42	110	30441	40589	32442386
Abdominal pain	43.29	21.42	46	30505	149483	32333492
Myocardial infarction	43.14	21.42	33	30518	125643	32357332
Physical assault	42.89	21.42	21	30530	1101	32481874
Somnolence	42.79	21.42	202	30349	103595	32379380
Homicide	42.63	21.42	20	30531	953	32482022
Nasopharyngitis	42.57	21.42	5	30546	63782	32419193
Methaemoglobinaemia	42.54	21.42	29	30522	2847	32480128
General physical health deterioration	42.53	21.42	28	30523	115231	32367744
Weight decreased	42.07	21.42	56	30495	164762	32318213
Neuropathy peripheral	40.68	21.42	11	30540	76971	32406004
Pulmonary embolism	40.52	21.42	14	30537	83645	32399330
Pleural effusion	40.42	21.42	12	30539	78980	32403995
Amnesia	40.28	21.42	79	30472	24957	32458018
Deep vein thrombosis	40.11	21.42	6	30545	63707	32419268
Urinary tract infection	39.48	21.42	13	30538	80058	32402917
Constipation	38.71	21.42	37	30514	126336	32356639
Malaise	37.73	21.42	68	30483	177070	32305905
Self-medication	37.59	21.42	25	30526	2356	32480619
Peripheral swelling	37.58	21.42	9	30542	68336	32414639
Joint swelling	37.29	21.42	3	30548	51732	32431243
Muscular weakness	37.25	21.42	9	30542	67920	32415055
Cluster headache	36.83	21.42	15	30536	506	32482469
Drug intolerance	35.97	21.42	3	30548	50232	32432743
Acute kidney injury	35.30	21.42	149	30402	293319	32189656
Erythema	35.23	21.42	17	30534	83088	32399887
Suicidal behaviour	34.83	21.42	20	30531	1451	32481524
Chronic obstructive pulmonary disease	34.66	21.42	3	30548	48750	32434225
Urticaria	34.50	21.42	7	30544	59607	32423368
Hepatic fibrosis	34.45	21.42	28	30523	3590	32479385
Septic shock	34.36	21.42	11	30540	68978	32413997
Loss of consciousness	34.09	21.42	161	30390	82546	32400429
Gun shot wound	34.07	21.42	18	30533	1108	32481867
Abnormal behaviour	33.81	21.42	76	30475	26390	32456585
Tachycardia	33.37	21.42	155	30396	78933	32404042
Weight increased	32.69	21.42	19	30532	83644	32399331
Dysarthria	32.45	21.42	86	30465	33115	32449860
Toxicologic test abnormal	32.42	21.42	14	30537	548	32482427
Dysphagia	32.07	21.42	9	30542	61467	32421508
Infusion related reaction	31.90	21.42	3	30548	45596	32437379
Exposure to toxic agent	31.82	21.42	17	30534	1071	32481904
Impaired driving ability	31.67	21.42	23	30528	2496	32480479
Chills	31.56	21.42	17	30534	78067	32404908
Pulmonary oedema	31.12	21.42	105	30446	46162	32436813
Renal failure	31.04	21.42	49	30502	134429	32348546
Myalgia	30.96	21.42	19	30532	81211	32401764
Thrombosis	29.52	21.42	4	30547	45750	32437225
Leukopenia	29.21	21.42	10	30541	60112	32422863
Prescription drug used without a prescription	28.81	21.42	17	30534	1298	32481677
Product use in unapproved indication	28.53	21.42	24	30527	87180	32395795
Foetal alcohol syndrome	28.20	21.42	9	30542	147	32482828
Influenza	27.47	21.42	5	30546	46009	32436966
Stomatitis	27.22	21.42	3	30548	40226	32442749
C-reactive protein increased	27.11	21.42	6	30545	48096	32434879
Exposure via inhalation	27.04	21.42	7	30544	51	32482924
Chest discomfort	26.87	21.42	7	30544	50223	32432752
Drug interaction	26.38	21.42	317	30234	217868	32265107
Haematochezia	26.34	21.42	3	30548	39205	32443770
Acidosis	26.28	21.42	41	30510	10805	32472170
Dyspnoea exertional	26.12	21.42	3	30548	38958	32444017
Hospitalisation	25.86	21.42	7	30544	48964	32434011
Accident	25.50	21.42	25	30526	4097	32478878
Bradypnoea	25.29	21.42	20	30531	2466	32480509
Drug hypersensitivity	24.71	21.42	135	30416	73265	32409710
Chronic kidney disease	24.62	21.42	4	30547	39971	32443004
Abdominal distension	24.12	21.42	9	30542	51286	32431689
Psoriasis	23.60	21.42	7	30544	46116	32436859
Haematuria	23.57	21.42	8	30543	48353	32434622
Pupil fixed	23.50	21.42	17	30534	1834	32481141
Acute hepatic failure	23.42	21.42	43	30508	12926	32470049
Cellulitis	23.31	21.42	9	30542	50221	32432754
Drug diversion	23.30	21.42	13	30538	892	32482083
Blood creatinine increased	23.16	21.42	34	30517	96098	32386877
Hypersensitivity	22.72	21.42	13	30538	57745	32425230
Fall	22.70	21.42	101	30450	196100	32286875
Sensorimotor disorder	22.61	21.42	10	30541	415	32482560
Legal problem	22.56	21.42	8	30543	183	32482792
Brain oedema	22.19	21.42	42	30509	12918	32470057
Alcoholic liver disease	22.09	21.42	11	30540	598	32482377
Sinus tachycardia	21.94	21.42	48	30503	16366	32466609
Musculoskeletal stiffness	21.92	21.42	5	30546	39259	32443716
Bronchitis	21.79	21.42	6	30545	41501	32441474
Drug level increased	21.67	21.42	54	30497	20026	32462949
Electrocardiogram QRS complex prolonged	21.58	21.42	24	30527	4550	32478425
Haemoptysis	21.46	21.42	3	30548	33522	32449453

Pharmacologic Action:

Source	Code	Description
ATC	D08AX08	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Other antiseptics and disinfectants
ATC	V03AB16	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Antidotes
ATC	V03AZ01	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Nerve depressants
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D012997	Solvents
CHEBI has role	CHEBI:35488	CNS depressants
CHEBI has role	CHEBI:48218	local microbicides
CHEBI has role	CHEBI:48219	Desinfektionsmittel
CHEBI has role	CHEBI:48354	polar solvents
CHEBI has role	CHEBI:50905	teratogen
CHEBI has role	CHEBI:50910	agente neurotoxico
CHEBI has role	CHEBI:60643	N-methyl-D-aspartate receptor antagonists
CHEBI has role	CHEBI:64018	protein kinase C agonists
CHEBI has role	CHEBI:75771	Mus musculus metabolite
CHEBI has role	CHEBI:75772	bakers yeast metabolite
CHEBI has role	CHEBI:76971	E.coli metabolites
CHEBI has role	CHEBI:77746	H. sapiens metabolites

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Antiseptic preparation	indication	261276004

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Exclusivity date	Description
99% (1ML)	ABLYSINOL	BELCHER	N207987	June 21, 2018	RX	SOLUTION	INTRA-ARTERIAL	June 21, 2025	INDICATED TO INDUCE CONTROLLED CARDIAC SEPTAL INFRACTION TO IMPROVE EXERCISE CAPACITY IN ADULTS WITH SYMPTOMATIC HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY WHO ARE NOT CANDIDATES FOR SURGICAL MYECTOMY
99% (5ML)	ABLYSINOL	BELCHER	N207987	June 21, 2018	RX	SOLUTION	INTRA-ARTERIAL	June 21, 2025	INDICATED TO INDUCE CONTROLLED CARDIAC SEPTAL INFRACTION TO IMPROVE EXERCISE CAPACITY IN ADULTS WITH SYMPTOMATIC HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY WHO ARE NOT CANDIDATES FOR SURGICAL MYECTOMY

Bioactivity Summary:

Target	Class	Pharos	UniProt	Bioact source
Glutamate receptor ionotropic, NMDA 3A	Ion channel	Q8TCU5	NMD3A_HUMAN	WOMBAT-PK
Glycine receptor subunit alpha-1	Ion channel	P23415	GLRA1_HUMAN	WOMBAT-PK
Glycine receptor subunit alpha-2	Ion channel	P23416	GLRA2_HUMAN	WOMBAT-PK
GABA A receptor alpha-4/beta-2/delta	Ion channel	O14764 P47870 P48169	GBRD_HUMAN GBRB2_HUMAN GBRA4_HUMAN	WOMBAT-PK

External reference:

ID	Source
4017736	VUID
N0000146104	NUI
D06542	KEGG_DRUG
4017424	VANDF
4017736	VANDF
C0001962	UMLSCUI
CHEBI:16236	CHEBI
EOH	PDB_CHEM_ID
CHEMBL545	ChEMBL_ID
702	PUBCHEM_CID
DB00898	DRUGBANK_ID
D000431	MESH_DESCRIPTOR_UI
2299	IUPHAR_LIGAND_ID
3K9958V90M	UNII
448	RXNORM
10010	MMSL
4693	MMSL
9888	MMSL
d03162	MMSL
001539	NDDF
002464	NDDF
333164008	SNOMEDCT_US
398624005	SNOMEDCT_US
419442005	SNOMEDCT_US
53041004	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
TRISEPTINHAND AND BODY ANTISEPTIC	HUMAN OTC DRUG LABEL	1	0064-1050	LOTION	0.70 mL	TOPICAL	OTC monograph not final	9 sections
SURGICEPT Waterless, Surgical Handscrub and Healthcare Personnel Handwash	HUMAN OTC DRUG LABEL	1	0064-1080	SOLUTION	0.75 mL	TOPICAL	OTC monograph not final	10 sections
hand sanitizer	HUMAN OTC DRUG LABEL	1	0113-7077	GEL	70 mL	TOPICAL	OTC monograph not final	12 sections
Humphreys Alcoholado Maravilla	HUMAN OTC DRUG LABEL	1	0219-2020	LIQUID	70 mL	TOPICAL	OTC MONOGRAPH NOT FINAL	13 sections
Nozin Nasal Sanitizer	HUMAN OTC DRUG LABEL	1	0295-9025	LIQUID	62 mL	TOPICAL	OTC monograph not final	9 sections
Keri Clinical Care Hand Sanitizing Gel - HEALTHCARE	HUMAN OTC DRUG LABEL	1	0316-0214	GEL	0.70 mL	TOPICAL	OTC monograph not final	11 sections
Keri Clinical Care Hand Sanitizing Gel	HUMAN OTC DRUG LABEL	1	0316-0292	GEL	0.70 mL	TOPICAL	OTC monograph not final	11 sections
SeptoSan Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0362-6000	LIQUID	60 L	TOPICAL	OTC MONOGRAPH NOT FINAL	14 sections
SeptoSan Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0362-6001	LIQUID	60 L	TOPICAL	OTC MONOGRAPH NOT FINAL	14 sections
SeptoSan Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0362-6002	LIQUID	60 L	TOPICAL	OTC MONOGRAPH NOT FINAL	14 sections
Alcohol	HUMAN OTC DRUG LABEL	1	0363-0046	LIQUID	62 mg	TOPICAL	OTC monograph not final	12 sections
Iodine	HUMAN OTC DRUG LABEL	3	0363-0088	LIQUID	470 mg	TOPICAL	OTC monograph not final	12 sections
Advanced Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0370	GEL	70 mL	TOPICAL	OTC monograph not final	12 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0469	GEL	545 mg	TOPICAL	OTC monograph not final	12 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0596	GEL	567 mg	TOPICAL	OTC monograph not final	12 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0643	GEL	558 mg	TOPICAL	OTC monograph not final	11 sections
Crisp Apple Hand Sani	HUMAN OTC DRUG LABEL	1	0363-0663	LIQUID	585 g	TOPICAL	OTC monograph not final	13 sections
Ethyl Rubbing Alcohol	HUMAN OTC DRUG LABEL	1	0363-0876	LIQUID	610 mg	TOPICAL	OTC monograph not final	13 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0890	GEL	567 mg	TOPICAL	OTC monograph not final	11 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0898	GEL	567 mg	TOPICAL	OTC monograph not final	11 sections
Advanced Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0952	GEL	700 mg	TOPICAL	OTC monograph not final	12 sections
WALGREENS ADVANCED HAND SANITIZER WITH FRESH SCENT	HUMAN OTC DRUG LABEL	1	0363-0967	AEROSOL, SPRAY	70 mg	TOPICAL	OTC monograph not final	12 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0968	LOTION	558 mg	TOPICAL	OTC monograph not final	13 sections
Walgreens Advanced Hand Sanitizer Citrus Scent	HUMAN OTC DRUG LABEL	1	0363-0969	AEROSOL, SPRAY	70 mg	TOPICAL	OTC monograph not final	12 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0984	GEL	567 mg	TOPICAL	OTC monograph not final	11 sections
A Little Something Eucalyptus Mist Hand Sanitier	HUMAN OTC DRUG LABEL	1	0363-1050	LIQUID	700 mg	TOPICAL	OTC monograph not final	1 sections
A Little Something Eucalyptus Mist Hand Sanitier	HUMAN OTC DRUG LABEL	1	0363-1050	LIQUID	700 mg	TOPICAL	OTC monograph not final	1 sections
A Little Something Prosecco Bubbles Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-1051	LIQUID	700 mg	TOPICAL	OTC monograph not final	1 sections
A Little Something Prosecco Bubbles Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-1051	LIQUID	700 mg	TOPICAL	OTC monograph not final	1 sections
WalgreensHand Sanitizer Aloe Vitamin E	HUMAN OTC DRUG LABEL	1	0363-1305	LIQUID	62 mL	TOPICAL	OTC monograph not final	11 sections