tixocortol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
corticosteroids, except prednisolone derivatives	4064	55560-96-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: tixocortol tixocortol pivalate pivalone rectovalone tiovalon	21-thiol derivative of hydrocortisone Molecular weight: 462.65 Formula: C26H38O5S CLOGP: 4.37 LIPINSKI: 0 HAC: 5 HDO: 2 TPSA: 91.67 ALOGS: -4.55 ROTB: 5

Molecule

Description

Molfile Inchi Smiles

Synonyms:

tixocortol
tixocortol pivalate
pivalone
rectovalone
tiovalon

21-thiol derivative of hydrocortisone

Molecular weight: 462.65
Formula: C26H38O5S
CLOGP: 4.37
LIPINSKI: 0
HAC: 5
HDO: 2
TPSA: 91.67
ALOGS: -4.55
ROTB: 5

Drug dosage:

Dose	Unit	Route
8	mg	N

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Necrosis ischaemic	155.70	104.66	20	216	840	63487946
Pneumonia streptococcal	140.81	104.66	20	216	1791	63486995
Beta haemolytic streptococcal infection	138.58	104.66	20	216	2005	63486781

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FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Necrosis ischaemic	148.13	67.98	20	317	1070	79742981
Beta haemolytic streptococcal infection	135.05	67.98	20	317	2077	79741974
Pneumonia streptococcal	129.67	67.98	20	317	2725	79741326

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A07EA05	ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFLAMMATORY AGENTS Corticosteroids acting locally
ATC	R01AD07	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids
ATC	R01AD57	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids
CHEBI has role	CHEBI:63562	glucocorticoid receptor agonists
CHEBI has role	CHEBI:50857	anti-allergic drugs
CHEBI has role	CHEBI:50904	alergeno
FDA CS	M0000728	Allergens
FDA EPC	N0000185508	Standardized Chemical Allergen
FDA PE	N0000175629	Increased Histamine Release
FDA PE	N0000184306	Cell-mediated Immunity

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Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.14	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
003663	NDDF
003664	NDDF
162955	PUBCHEM_CID
38336	RXNORM
4027692	VUID
4027692	VANDF
4027693	VANDF
412322004	SNOMEDCT_US
4125	INN_ID
61951-99-3	SECONDARY_CAS_RN

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Pharmaceutical products:

None