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tixocortol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| corticosteroids, except prednisolone derivatives | 4064 | 55560-96-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
21-thiol derivative of hydrocortisone
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 8 | mg | N |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 45 | |||
| kinase-selectivity-class | GRK2 | 1 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 3.864 | Moderate | 0.74 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| rat-kpuu-brain | Rat brain Kpuu | 0.114 | % | Moderate | 0.74 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Necrosis ischaemic | 155.05 | 92.07 | 20 | 278 | 975 | 90627174 |
| Pneumonia streptococcal | 139.73 | 92.07 | 20 | 278 | 2121 | 90626028 |
| Beta haemolytic streptococcal infection | 136.48 | 92.07 | 20 | 278 | 2499 | 90625650 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Necrosis ischaemic | 144.55 | 69.86 | 20 | 425 | 1339 | 110587515 |
| Beta haemolytic streptococcal infection | 128.92 | 69.86 | 20 | 425 | 2951 | 110585903 |
| Pneumonia streptococcal | 125.70 | 69.86 | 20 | 425 | 3469 | 110585385 |
| Rash maculo-papular | 86.68 | 69.86 | 25 | 420 | 74197 | 110514657 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A07EA05 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFLAMMATORY AGENTS Corticosteroids acting locally |
| ATC | R01AD07 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
| ATC | R01AD57 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
| FDA CS | M0000728 | Allergens |
| MeSH PA | D018926 | Anti-Allergic Agents |
| FDA PE | N0000175629 | Increased Histamine Release |
| FDA PE | N0000184306 | Cell-mediated Immunity |
| FDA EPC | N0000185508 | Standardized Chemical Allergen |
| CHEBI has role | CHEBI:63562 | glucocorticoid receptor agonist |
| CHEBI has role | CHEBI:50857 | anti-allergic agent |
| CHEBI has role | CHEBI:50904 | allergen |
| CHEBI has role | CHEBI:77715 | nasal decongestant |
Related Drugs by ATC class:
A07EA Corticosteroids acting locally 6 drugs
R01AD Corticosteroids 12 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.14 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4027692 | VUID |
| N0000179344 | NUI |
| D06171 | KEGG_DRUG |
| 61951-99-3 | SECONDARY_CAS_RN |
| 4027692 | VANDF |
| 4027693 | VANDF |
| C0146010 | UMLSCUI |
| CHEBI:63560 | CHEBI |
| CHEMBL2107112 | ChEMBL_ID |
| DB09091 | DRUGBANK_ID |
| C040971 | MESH_SUPPLEMENTAL_RECORD_UI |
| 162955 | PUBCHEM_CID |
| C019112 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4125 | INN_ID |
| ZX3KEK657Z | UNII |
| 38336 | RXNORM |
| 003663 | NDDF |
| 003664 | NDDF |
| 412322004 | SNOMEDCT_US |
| 734662006 | SNOMEDCT_US |
Pharmaceutical products:
None