tixocortol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| corticosteroids, except prednisolone derivatives | 4064 | 55560-96-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
21-thiol derivative of hydrocortisone
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 8 | mg | N |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Necrosis ischaemic | 155.70 | 104.66 | 20 | 216 | 840 | 63487946 |
| Pneumonia streptococcal | 140.81 | 104.66 | 20 | 216 | 1791 | 63486995 |
| Beta haemolytic streptococcal infection | 138.58 | 104.66 | 20 | 216 | 2005 | 63486781 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Necrosis ischaemic | 148.13 | 67.98 | 20 | 317 | 1070 | 79742981 |
| Beta haemolytic streptococcal infection | 135.05 | 67.98 | 20 | 317 | 2077 | 79741974 |
| Pneumonia streptococcal | 129.67 | 67.98 | 20 | 317 | 2725 | 79741326 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A07EA05 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFLAMMATORY AGENTS Corticosteroids acting locally |
| ATC | R01AD07 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
| ATC | R01AD57 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
| FDA CS | M0000728 | Allergens |
| MeSH PA | D018926 | Anti-Allergic Agents |
| FDA PE | N0000175629 | Increased Histamine Release |
| FDA PE | N0000184306 | Cell-mediated Immunity |
| FDA EPC | N0000185508 | Standardized Chemical Allergen |
| CHEBI has role | CHEBI:63562 | glucocorticoid receptor agonists |
| CHEBI has role | CHEBI:50857 | anti-allergic drugs |
| CHEBI has role | CHEBI:50904 | alergeno |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.14 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4027692 | VUID |
| N0000179344 | NUI |
| D06171 | KEGG_DRUG |
| 4027692 | VANDF |
| 4027693 | VANDF |
| C0146010 | UMLSCUI |
| CHEBI:63560 | CHEBI |
| CHEMBL2107112 | ChEMBL_ID |
| DB09091 | DRUGBANK_ID |
| C040971 | MESH_SUPPLEMENTAL_RECORD_UI |
| C019112 | MESH_SUPPLEMENTAL_RECORD_UI |
| 162955 | PUBCHEM_CID |
| 4125 | INN_ID |
| ZX3KEK657Z | UNII |
| 38336 | RXNORM |
| 003663 | NDDF |
| 003664 | NDDF |
| 412322004 | SNOMEDCT_US |
| 734662006 | SNOMEDCT_US |
| 61951-99-3 | SECONDARY_CAS_RN |
Pharmaceutical products:
None