hydroxocobalamin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4309	13422-51-0

Description:

Molecule	Description
Synonyms: hydroxocobalamin hydrocobalamin hydroxocobalamine hydroxocobemine Hydroxy vitamin B12 hydroxycobalamin hydroxycobalamine Cyanokit	Injectable form of VITAMIN B 12 that has been used therapeutically to treat VITAMIN B 12 DEFICIENCY. Molecular weight: 1346.38 Formula: C62H89CoN13O15P CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 508.94 ALOGS: ROTB: None

Molecule

Description

Synonyms:

hydroxocobalamin
hydrocobalamin
hydroxocobalamine
hydroxocobemine
Hydroxy vitamin B12
hydroxycobalamin
hydroxycobalamine
Cyanokit

Injectable form of VITAMIN B 12 that has been used therapeutically to treat VITAMIN B 12 DEFICIENCY.

Molecular weight: 1346.38
Formula: C62H89CoN13O15P
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 508.94
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
20	mcg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Aug. 16, 1978	FDA	WATSON LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyponatraemia	116.78	21.07	80	4217	111820	63372905
Pneumonia aspiration	56.81	21.07	33	4264	34507	63450218
Neutropenic sepsis	50.89	21.07	24	4273	16414	63468311
Acute kidney injury	48.09	21.07	73	4224	263342	63221383
Forceps delivery	42.31	21.07	8	4289	212	63484513
Lethargy	42.30	21.07	33	4264	55974	63428751
Somnolence	40.62	21.07	55	4242	178630	63306095
Food refusal	38.06	21.07	8	4289	367	63484358
Nystagmus	35.50	21.07	14	4283	6206	63478519
Coma	34.27	21.07	31	4266	64333	63420392
Developmental hip dysplasia	32.27	21.07	9	4288	1363	63483362
Pelvic deformity	29.57	21.07	6	4291	231	63484494
Haemorrhage in pregnancy	29.26	21.07	9	4288	1916	63482809
Inappropriate antidiuretic hormone secretion	28.71	21.07	16	4281	15446	63469279
Urosepsis	28.60	21.07	17	4280	18507	63466218
Coma scale abnormal	27.33	21.07	11	4286	5142	63479583
Dystrophic calcification	26.57	21.07	5	4292	129	63484596
Drug ineffective	25.76	21.07	20	4277	1044745	62439980
Swelling face	25.16	21.07	26	4271	63449	63421276
Underdose	22.52	21.07	17	4280	27439	63457286
Chromaturia	22.37	21.07	14	4283	16703	63468022
Eye swelling	22.30	21.07	16	4281	23902	63460823

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Chromaturia	69.22	21.48	31	3051	14489	34939360
Acute kidney injury	52.56	21.48	95	2987	304893	34648956
Orthostatic hypotension	34.80	21.48	24	3058	25895	34927954
Drug-device interaction	33.35	21.48	4	3078	0	34953849
Loss of proprioception	30.08	21.48	7	3075	393	34953456
Mean arterial pressure increased	28.34	21.48	4	3078	10	34953839
Lower respiratory tract infection	26.29	21.48	22	3060	31615	34922234
Confusional state	26.06	21.48	46	3036	144114	34809735
Normocytic anaemia	25.18	21.48	9	3073	2335	34951514
Hypomania	25.13	21.48	9	3073	2350	34951499
Serum colour abnormal	25.01	21.48	3	3079	0	34953849
Methaemoglobinaemia	24.89	21.48	10	3072	3571	34950278
Neutropenic sepsis	23.96	21.48	15	3067	13752	34940097
Cardiac flutter	23.30	21.48	8	3074	1845	34952004
Funguria	22.52	21.48	4	3078	56	34953793

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	101.63	18.54	173	6983	519231	79218001
Hyponatraemia	94.47	18.54	97	7059	177751	79559481
Chromaturia	85.15	18.54	43	7113	25703	79711529
Neutropenic sepsis	63.57	18.54	36	7120	27028	79710204
Pneumonia aspiration	53.75	18.54	46	7110	66921	79670311
Orthostatic hypotension	43.88	18.54	38	7118	56126	79681106
Confusional state	39.89	18.54	88	7068	317909	79419323
Swelling face	32.69	18.54	36	7120	71176	79666056
Food refusal	32.62	18.54	8	7148	552	79736680
Coma	31.66	18.54	42	7114	100607	79636625
Somnolence	30.92	18.54	67	7089	238914	79498318
Hallucination	30.45	18.54	38	7118	85707	79651525
Lethargy	30.44	18.54	37	7119	81255	79655977
Skin abrasion	29.18	18.54	17	7139	13439	79723793
Lip swelling	28.60	18.54	26	7130	40885	79696347
Liver function test abnormal	28.57	18.54	32	7124	64443	79672789
Dizziness	27.97	18.54	107	7049	526334	79210898
Methaemoglobinaemia	26.68	18.54	12	7144	5545	79731687
Laboratory test interference	26.57	18.54	8	7148	1193	79736039
Forceps delivery	25.59	18.54	5	7151	118	79737114
Nystagmus	25.50	18.54	14	7142	9890	79727342
Loss of proprioception	25.26	18.54	7	7149	779	79736453
Dystrophic calcification	24.98	18.54	5	7151	134	79737098
Mean arterial pressure increased	22.65	18.54	4	7152	53	79737179
Serum colour abnormal	22.42	18.54	3	7153	4	79737228
Bradycardia	22.27	18.54	42	7114	135515	79601717
Haemorrhage in pregnancy	21.20	18.54	7	7149	1407	79735825
Lower respiratory tract infection	21.18	18.54	40	7116	129180	79608052
Sarcoma	19.70	18.54	6	7150	930	79736302
Eye swelling	18.85	18.54	17	7139	26451	79710781
Urosepsis	18.83	18.54	17	7139	26478	79710754

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B03BA03	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS VITAMIN B12 AND FOLIC ACID Vitamin B12 (cyanocobalamin and analogues)
ATC	B03BA53	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS VITAMIN B12 AND FOLIC ACID Vitamin B12 (cyanocobalamin and analogues)
ATC	V03AB33	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Antidotes
FDA EPC	N0000175429	Antidote
MeSH PA	D006397	Hematinics
MeSH PA	D006401	Hematologic Agents
MeSH PA	D018977	Micronutrients
MeSH PA	D014803	Vitamin B Complex
MeSH PA	D014815	Vitamins
CHEBI has role	CHEBI:75835	antianaemic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Toxic effect of cyanide	indication	66207005
Pernicious anemia	indication	84027009	DOID:13381
Cobalamin deficiency	indication	190634004
Prevention of Vitamin B12 Deficiency	indication
Methylmalonic acidemia	off-label use	42393006
Hypertensive disorder	contraindication	38341003	DOID:10763

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4017961	VUID
N0000146311	NUI
D01027	KEGG_DRUG
4017961	VANDF
C0020316	UMLSCUI
CHEBI:27786	CHEBI
I2A	PDB_CHEM_ID
CHEMBL2103737	ChEMBL_ID
D006879	MESH_DESCRIPTOR_UI
DB00200	DRUGBANK_ID
1043	INN_ID
Q40X8H422O	UNII
24892771	PUBCHEM_CID
5514	RXNORM
4850	MMSL
7093	MMSL
92212	MMSL
d03133	MMSL
001044	NDDF
1217428002	SNOMEDCT_US
327529002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Cyanokit	HUMAN PRESCRIPTION DRUG LABEL	1	11704-370	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	5 g	INTRAVENOUS	NDA	29 sections
Cyanokit	HUMAN PRESCRIPTION DRUG LABEL	1	50633-310	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	5 g	INTRAVENOUS	NDA	28 sections
Cyanokit	HUMAN PRESCRIPTION DRUG LABEL	1	50633-310	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	5 g	INTRAVENOUS	NDA	28 sections