All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

hydroxocobalamin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4309	13422-51-0

Description:

Molecule	Description
Synonyms: hydroxocobalamin hydrocobalamin hydroxocobalamine hydroxocobemine Hydroxy vitamin B12 hydroxycobalamin hydroxycobalamine Cyanokit	Injectable form of VITAMIN B 12 that has been used therapeutically to treat VITAMIN B 12 DEFICIENCY. Molecular weight: 1346.38 Formula: C62H89CoN13O15P CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 508.94 ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
20	mcg	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
Aug. 16, 1978	FDA	WATSON LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyponatraemia	122.77	22.21	84	5295	133454	90489614
Pneumonia aspiration	69.04	22.21	38	5341	40902	90582166
Lip swelling	65.55	22.21	36	5343	38574	90584494
Acute kidney injury	63.22	22.21	86	5293	320301	90302767
Somnolence	58.67	22.21	67	5312	209017	90414051
Neutropenic sepsis	57.94	22.21	26	5353	18104	90604964
Lethargy	53.88	22.21	38	5341	63101	90559967
Swelling face	47.41	22.21	39	5340	81313	90541755
Coma	44.81	22.21	36	5343	72596	90550472
Forceps delivery	44.04	22.21	8	5371	194	90622874
Nystagmus	35.24	22.21	14	5365	7213	90615855
Food refusal	34.91	22.21	8	5371	627	90622441
Pyroglutamic acidosis	34.06	22.21	9	5370	1271	90621797
Hallucination	33.05	22.21	29	5350	65930	90557138
Developmental hip dysplasia	32.15	22.21	9	5370	1576	90621492
Coma scale abnormal	31.33	22.21	12	5367	5614	90617454
Pelvic deformity	30.38	22.21	6	5373	230	90622838
Chromaturia	30.12	22.21	17	5362	19170	90603898
Haemorrhage in pregnancy	29.30	22.21	9	5370	2176	90620892
Laboratory test interference	29.14	22.21	7	5372	673	90622395
Inappropriate antidiuretic hormone secretion	27.20	22.21	16	5363	19489	90603579
Halo vision	26.56	22.21	6	5373	441	90622627
Dystrophic calcification	25.38	22.21	5	5374	189	90622879
Myalgia	24.38	22.21	40	5339	175085	90447983
Underdose	23.61	22.21	22	5357	53995	90569073

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Chromaturia	92.94	21.28	39	3635	15950	42601711
Acute kidney injury	64.64	21.28	114	3560	367223	42250438
Drug-device interaction	53.25	21.28	8	3666	36	42617625
Dizziness	35.69	21.28	71	3603	249183	42368478
Neuropathy vitamin B12 deficiency	34.73	21.28	7	3667	203	42617458
Orthostatic hypotension	33.95	21.28	25	3649	30545	42587116
Loss of proprioception	29.38	21.28	7	3667	445	42617216
Serum colour abnormal	25.08	21.28	3	3671	0	42617661
Pancreatitis necrotising	24.92	21.28	10	3664	3639	42614022
Hypomania	24.79	21.28	9	3665	2499	42615162
Confusional state	24.24	21.28	48	3626	167549	42450112
Lower respiratory tract infection	23.57	21.28	23	3651	41183	42576478
Laboratory test interference	22.61	21.28	6	3668	591	42617070
Mean arterial pressure increased	22.35	21.28	4	3670	60	42617601
Cardiac flutter	22.35	21.28	8	3666	2132	42615529
Neutropenic sepsis	22.25	21.28	15	3659	15931	42601730
Liver function test abnormal	22.21	21.28	20	3654	32371	42585290
Normocytic anaemia	21.68	21.28	9	3665	3568	42614093
Funguria	21.56	21.28	4	3670	74	42617587

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	135.72	19.19	206	8571	635224	109945298
Chromaturia	118.21	19.19	54	8723	29306	110551216
Hyponatraemia	95.03	19.19	101	8676	217552	110362970
Lip swelling	80.16	19.19	50	8727	50617	110529905
Neutropenic sepsis	68.84	19.19	38	8739	30708	110549814
Pneumonia aspiration	65.22	19.19	53	8724	81180	110499342
Swelling face	63.32	19.19	55	8722	92266	110488256
Laboratory test interference	49.19	19.19	13	8764	1370	110579152
Orthostatic hypotension	44.47	19.19	39	8738	66210	110514312
Lethargy	43.58	19.19	45	8732	93531	110486991
Hallucination	42.31	19.19	46	8731	101386	110479136
Dizziness	41.89	19.19	136	8641	698057	109882465
Somnolence	41.43	19.19	80	8697	297369	110283153
Coma	38.31	19.19	47	8730	117822	110462700
Liver function test abnormal	35.47	19.19	35	8742	68915	110511607
Confusional state	35.33	19.19	99	8678	468581	110111941
Drug-device interaction	32.25	19.19	6	8771	123	110580399
Bradycardia	30.98	19.19	49	8728	155468	110425054
Neuropathy vitamin B12 deficiency	29.97	19.19	6	8771	183	110580339
Food refusal	29.39	19.19	8	8769	942	110579580
Skin abrasion	28.24	19.19	17	8760	16134	110564388
Swollen tongue	28.04	19.19	29	8748	60333	110520189
Myalgia	26.39	19.19	56	8721	222325	110358197
Forceps delivery	26.25	19.19	5	8772	117	110580405
Methaemoglobinaemia	25.21	19.19	13	8764	9155	110571367
Loss of proprioception	25.06	19.19	7	8770	907	110579615
Nystagmus	25.06	19.19	14	8763	11563	110568959
Metabolic acidosis	24.98	19.19	35	8742	99709	110480813
Malaise	24.64	19.19	112	8665	671707	109908815
Dystrophic calcification	24.22	19.19	5	8772	178	110580344
Pyroglutamic acidosis	23.26	19.19	8	8769	2060	110578462
Halo vision	22.46	19.19	6	8771	659	110579863
Serum colour abnormal	22.03	19.19	3	8774	6	110580516
Pancreatitis necrotising	21.76	19.19	10	8767	5491	110575031
Haemorrhage in pregnancy	20.91	19.19	7	8770	1661	110578861
Faeces discoloured	20.82	19.19	19	8758	33929	110546593
Mean arterial pressure increased	20.14	19.19	4	8773	117	110580405
Sarcoma	19.93	19.19	6	8771	1011	110579511
Vision blurred	19.54	19.19	36	8741	128986	110451536

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B03BA03	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS VITAMIN B12 AND FOLIC ACID Vitamin B12 (cyanocobalamin and analogues)
ATC	B03BA53	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS VITAMIN B12 AND FOLIC ACID Vitamin B12 (cyanocobalamin and analogues)
ATC	V03AB33	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Antidotes
FDA EPC	N0000175429	Antidote
MeSH PA	D006397	Hematinics
MeSH PA	D006401	Hematologic Agents
MeSH PA	D014803	Vitamin B Complex
MeSH PA	D014815	Vitamins
MeSH PA	D018977	Micronutrients
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:50247	antidote
CHEBI has role	CHEBI:66981	ophthalmology drug
CHEBI has role	CHEBI:67079	anti-inflammatory agent
CHEBI has role	CHEBI:75835	anti-anaemic agent
CHEBI has role	CHEBI:90749	antidote to cyanide poisoning

Related Drugs by ATC class:

B03BA Vitamin B12 (cyanocobalamin and analogues) 3 drugs

cobamamidecyanocobalaminmecobalamin

V03AB Antidotes 28 drugs

4-dimethylaminophenolacetylcysteineamyl nitriteandexanet alfaatropinecopper sulfatedimercaprolethanolflumazenilfomepizoleglutathioneidarucizumab show all 28 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Toxic effect of cyanide	indication	66207005
Pernicious anemia	indication	84027009	DOID:13381
Cobalamin deficiency	indication	190634004
Prevention of Vitamin B12 Deficiency	indication
Methylmalonic acidemia	off-label use	42393006
Hypertensive disorder	contraindication	38341003	DOID:10763

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4017961	VUID
N0000146311	NUI
D01027	KEGG_DRUG
4017961	VANDF
C0020316	UMLSCUI
CHEBI:27786	CHEBI
I2A	PDB_CHEM_ID
CHEMBL2103737	ChEMBL_ID
D006879	MESH_DESCRIPTOR_UI
DB00200	DRUGBANK_ID
1043	INN_ID
Q40X8H422O	UNII
44475014	PUBCHEM_CID
5514	RXNORM
399994	MMSL
4850	MMSL
7093	MMSL
92212	MMSL
d03133	MMSL
001044	NDDF
1217428002	SNOMEDCT_US
327529002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Cyanokit	HUMAN PRESCRIPTION DRUG LABEL	1	50633-310	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	5 g	INTRAVENOUS	NDA	28 sections
Hydroxocobalamin	HUMAN PRESCRIPTION DRUG LABEL	1	85551-125	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	7 sections