hydroxocobalamin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4309 13422-51-0

Description:

MoleculeDescription

Synonyms:

  • hydroxocobalamin
  • hydrocobalamin
  • hydroxocobalamine
  • hydroxocobemine
  • Hydroxy vitamin B12
  • hydroxycobalamin
  • hydroxycobalamine
  • Cyanokit
Injectable form of VITAMIN B 12 that has been used therapeutically to treat VITAMIN B 12 DEFICIENCY.
  • Molecular weight: 1346.38
  • Formula: C62H89CoN13O15P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 508.94
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
20 mcg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Aug. 16, 1978 FDA WATSON LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 122.77 22.21 84 5295 133454 90489614
Pneumonia aspiration 69.04 22.21 38 5341 40902 90582166
Lip swelling 65.55 22.21 36 5343 38574 90584494
Acute kidney injury 63.22 22.21 86 5293 320301 90302767
Somnolence 58.67 22.21 67 5312 209017 90414051
Neutropenic sepsis 57.94 22.21 26 5353 18104 90604964
Lethargy 53.88 22.21 38 5341 63101 90559967
Swelling face 47.41 22.21 39 5340 81313 90541755
Coma 44.81 22.21 36 5343 72596 90550472
Forceps delivery 44.04 22.21 8 5371 194 90622874
Nystagmus 35.24 22.21 14 5365 7213 90615855
Food refusal 34.91 22.21 8 5371 627 90622441
Pyroglutamic acidosis 34.06 22.21 9 5370 1271 90621797
Hallucination 33.05 22.21 29 5350 65930 90557138
Developmental hip dysplasia 32.15 22.21 9 5370 1576 90621492
Coma scale abnormal 31.33 22.21 12 5367 5614 90617454
Pelvic deformity 30.38 22.21 6 5373 230 90622838
Chromaturia 30.12 22.21 17 5362 19170 90603898
Haemorrhage in pregnancy 29.30 22.21 9 5370 2176 90620892
Laboratory test interference 29.14 22.21 7 5372 673 90622395
Inappropriate antidiuretic hormone secretion 27.20 22.21 16 5363 19489 90603579
Halo vision 26.56 22.21 6 5373 441 90622627
Dystrophic calcification 25.38 22.21 5 5374 189 90622879
Myalgia 24.38 22.21 40 5339 175085 90447983
Underdose 23.61 22.21 22 5357 53995 90569073

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Chromaturia 92.94 21.28 39 3635 15950 42601711
Acute kidney injury 64.64 21.28 114 3560 367223 42250438
Drug-device interaction 53.25 21.28 8 3666 36 42617625
Dizziness 35.69 21.28 71 3603 249183 42368478
Neuropathy vitamin B12 deficiency 34.73 21.28 7 3667 203 42617458
Orthostatic hypotension 33.95 21.28 25 3649 30545 42587116
Loss of proprioception 29.38 21.28 7 3667 445 42617216
Serum colour abnormal 25.08 21.28 3 3671 0 42617661
Pancreatitis necrotising 24.92 21.28 10 3664 3639 42614022
Hypomania 24.79 21.28 9 3665 2499 42615162
Confusional state 24.24 21.28 48 3626 167549 42450112
Lower respiratory tract infection 23.57 21.28 23 3651 41183 42576478
Laboratory test interference 22.61 21.28 6 3668 591 42617070
Mean arterial pressure increased 22.35 21.28 4 3670 60 42617601
Cardiac flutter 22.35 21.28 8 3666 2132 42615529
Neutropenic sepsis 22.25 21.28 15 3659 15931 42601730
Liver function test abnormal 22.21 21.28 20 3654 32371 42585290
Normocytic anaemia 21.68 21.28 9 3665 3568 42614093
Funguria 21.56 21.28 4 3670 74 42617587

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 135.72 19.19 206 8571 635224 109945298
Chromaturia 118.21 19.19 54 8723 29306 110551216
Hyponatraemia 95.03 19.19 101 8676 217552 110362970
Lip swelling 80.16 19.19 50 8727 50617 110529905
Neutropenic sepsis 68.84 19.19 38 8739 30708 110549814
Pneumonia aspiration 65.22 19.19 53 8724 81180 110499342
Swelling face 63.32 19.19 55 8722 92266 110488256
Laboratory test interference 49.19 19.19 13 8764 1370 110579152
Orthostatic hypotension 44.47 19.19 39 8738 66210 110514312
Lethargy 43.58 19.19 45 8732 93531 110486991
Hallucination 42.31 19.19 46 8731 101386 110479136
Dizziness 41.89 19.19 136 8641 698057 109882465
Somnolence 41.43 19.19 80 8697 297369 110283153
Coma 38.31 19.19 47 8730 117822 110462700
Liver function test abnormal 35.47 19.19 35 8742 68915 110511607
Confusional state 35.33 19.19 99 8678 468581 110111941
Drug-device interaction 32.25 19.19 6 8771 123 110580399
Bradycardia 30.98 19.19 49 8728 155468 110425054
Neuropathy vitamin B12 deficiency 29.97 19.19 6 8771 183 110580339
Food refusal 29.39 19.19 8 8769 942 110579580
Skin abrasion 28.24 19.19 17 8760 16134 110564388
Swollen tongue 28.04 19.19 29 8748 60333 110520189
Myalgia 26.39 19.19 56 8721 222325 110358197
Forceps delivery 26.25 19.19 5 8772 117 110580405
Methaemoglobinaemia 25.21 19.19 13 8764 9155 110571367
Loss of proprioception 25.06 19.19 7 8770 907 110579615
Nystagmus 25.06 19.19 14 8763 11563 110568959
Metabolic acidosis 24.98 19.19 35 8742 99709 110480813
Malaise 24.64 19.19 112 8665 671707 109908815
Dystrophic calcification 24.22 19.19 5 8772 178 110580344
Pyroglutamic acidosis 23.26 19.19 8 8769 2060 110578462
Halo vision 22.46 19.19 6 8771 659 110579863
Serum colour abnormal 22.03 19.19 3 8774 6 110580516
Pancreatitis necrotising 21.76 19.19 10 8767 5491 110575031
Haemorrhage in pregnancy 20.91 19.19 7 8770 1661 110578861
Faeces discoloured 20.82 19.19 19 8758 33929 110546593
Mean arterial pressure increased 20.14 19.19 4 8773 117 110580405
Sarcoma 19.93 19.19 6 8771 1011 110579511
Vision blurred 19.54 19.19 36 8741 128986 110451536

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03BA03 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
ATC B03BA53 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
ATC V03AB33 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
FDA EPC N0000175429 Antidote
MeSH PA D006397 Hematinics
MeSH PA D006401 Hematologic Agents
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50247 antidote
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:90749 antidote to cyanide poisoning

Related Drugs by ATC class:

B03BA Vitamin B12 (cyanocobalamin and analogues) 3 drugs
cobamamidecyanocobalaminmecobalamin
V03AB Antidotes 28 drugs
4-dimethylaminophenolacetylcysteineamyl nitriteandexanet alfaatropinecopper sulfatedimercaprolethanolflumazenilfomepizoleglutathioneidarucizumab show all 28 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Toxic effect of cyanide indication 66207005
Pernicious anemia indication 84027009 DOID:13381
Cobalamin deficiency indication 190634004
Prevention of Vitamin B12 Deficiency indication
Methylmalonic acidemia off-label use 42393006
Hypertensive disorder contraindication 38341003 DOID:10763




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017961 VUID
N0000146311 NUI
D01027 KEGG_DRUG
4017961 VANDF
C0020316 UMLSCUI
CHEBI:27786 CHEBI
I2A PDB_CHEM_ID
CHEMBL2103737 ChEMBL_ID
D006879 MESH_DESCRIPTOR_UI
DB00200 DRUGBANK_ID
1043 INN_ID
Q40X8H422O UNII
44475014 PUBCHEM_CID
5514 RXNORM
399994 MMSL
4850 MMSL
7093 MMSL
92212 MMSL
d03133 MMSL
001044 NDDF
1217428002 SNOMEDCT_US
327529002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyanokit HUMAN PRESCRIPTION DRUG LABEL 1 50633-310 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 5 g INTRAVENOUS NDA 28 sections
Hydroxocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 85551-125 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 7 sections