hydroxocobalamin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4309 13422-51-0

Description:

MoleculeDescription

Synonyms:

  • hydroxocobalamin
  • hydrocobalamin
  • hydroxocobalamine
  • hydroxocobemine
  • Hydroxy vitamin B12
  • hydroxycobalamin
  • hydroxycobalamine
  • Cyanokit
Injectable form of VITAMIN B 12 that has been used therapeutically to treat VITAMIN B 12 DEFICIENCY.
  • Molecular weight: 1346.38
  • Formula: C62H89CoN13O15P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 508.94
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
20 mcg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 16, 1978 FDA WATSON LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 119.23 22.72 80 3778 96059 50505207
Neutropenic sepsis 48.52 22.72 23 3835 14124 50587142
Pneumonia aspiration 46.16 22.72 29 3829 30975 50570291
Lethargy 42.48 22.72 33 3825 49399 50551867
Forceps delivery 42.41 22.72 8 3850 185 50601081
Acute kidney injury 41.09 22.72 67 3791 227991 50373275
Food refusal 38.33 22.72 8 3850 314 50600952
Somnolence 35.60 22.72 51 3807 154934 50446332
Nystagmus 35.41 22.72 14 3844 5547 50595719
Developmental hip dysplasia 31.75 22.72 9 3849 1282 50599984
Inappropriate antidiuretic hormone secretion 29.36 22.72 16 3842 13127 50588139
Haemorrhage in pregnancy 29.26 22.72 9 3849 1700 50599566
Pelvic deformity 29.06 22.72 6 3852 223 50601043
Coma scale abnormal 26.88 22.72 11 3847 4760 50596506
Dystrophic calcification 26.61 22.72 5 3853 113 50601153
Urosepsis 24.35 22.72 15 3843 15450 50585816
Coma 23.19 22.72 25 3833 56854 50544412

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Chromaturia 62.01 23.01 28 2695 12774 29559030
Acute kidney injury 51.29 23.01 89 2634 265178 29306626
Loss of proprioception 30.25 23.01 7 2716 367 29571437
Orthostatic hypotension 29.67 23.01 21 2702 22608 29549196
Mean arterial pressure increased 28.17 23.01 4 2719 10 29571794
Confusional state 27.31 23.01 45 2678 127832 29443972
Normocytic anaemia 26.24 23.01 9 2714 1983 29569821
Hypomania 25.46 23.01 9 2714 2166 29569638
Cardiac flutter 23.78 23.01 8 2715 1662 29570142
Dizziness 23.54 23.01 53 2670 189631 29382173

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 94.02 18.10 163 6237 449077 64043255
Hyponatraemia 91.79 18.10 92 6308 148247 64344085
Chromaturia 77.59 18.10 40 6360 22571 64469761
Neutropenic sepsis 54.50 18.10 32 6368 23240 64469092
Pneumonia aspiration 46.55 18.10 42 6358 59229 64433103
Orthostatic hypotension 40.45 18.10 35 6365 46703 64445629
Confusional state 39.79 18.10 83 6317 261061 64231271
Food refusal 33.47 18.10 8 6392 447 64491885
Dizziness 31.60 18.10 104 6296 430059 64062273
Lethargy 30.82 18.10 37 6363 72557 64419775
Swelling face 29.90 18.10 33 6367 59133 64433199
Skin abrasion 29.88 18.10 17 6383 11628 64480704
Hallucination 29.12 18.10 36 6364 72752 64419580
Somnolence 27.85 18.10 62 6338 203583 64288749
Liver function test abnormal 26.40 18.10 31 6369 59370 64432962
Forceps delivery 26.12 18.10 5 6395 95 64492237
Loss of proprioception 25.54 18.10 7 6393 675 64491657
Nystagmus 25.34 18.10 14 6386 9054 64483278
Dystrophic calcification 24.89 18.10 5 6395 123 64492209
Serum colour abnormal 24.66 18.10 3 6397 0 64492332
Lip swelling 23.84 18.10 22 6378 31885 64460447
Laboratory test interference 22.64 18.10 7 6393 1031 64491301
Mean arterial pressure increased 22.25 18.10 4 6396 53 64492279
Lower respiratory tract infection 21.83 18.10 36 6364 94578 64397754
Haemorrhage in pregnancy 21.20 18.10 7 6393 1273 64491059
Malaise 19.24 18.10 84 6316 396163 64096169
Coma 18.44 18.10 32 6368 87583 64404749

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03BA03 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
ATC B03BA53 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
ATC V03AB33 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
FDA EPC N0000175429 Antidote
MeSH PA D006397 Hematinics
MeSH PA D006401 Hematologic Agents
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:75835 antianaemic drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Toxic effect of cyanide indication 66207005
Pernicious anemia indication 84027009 DOID:13381
Cobalamin deficiency indication 190634004
Prevention of Vitamin B12 Deficiency indication
Methylmalonic acidemia off-label use 42393006
Hypertensive disorder contraindication 38341003 DOID:10763




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017961 VUID
N0000146311 NUI
D01027 KEGG_DRUG
4017961 VANDF
C0020316 UMLSCUI
CHEBI:27786 CHEBI
I2A PDB_CHEM_ID
CHEMBL2103737 ChEMBL_ID
D006879 MESH_DESCRIPTOR_UI
DB00200 DRUGBANK_ID
1043 INN_ID
Q40X8H422O UNII
44475014 PUBCHEM_CID
5514 RXNORM
4850 MMSL
7093 MMSL
92212 MMSL
d03133 MMSL
001044 NDDF
327529002 SNOMEDCT_US
409258004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyanokit HUMAN PRESCRIPTION DRUG LABEL 1 11704-370 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 5 g INTRAVENOUS NDA 29 sections
Cyanokit HUMAN PRESCRIPTION DRUG LABEL 1 50633-310 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 5 g INTRAVENOUS NDA 28 sections