clobetasone butyrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3911 25122-57-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • eumovate
  • kindavate
  • clobetasone butyrate
  • 21-Chloro-11-dehydrobetamethasone
  • clobetasone 17-butyrate
  • Molecular weight: 478.99
  • Formula: C26H32ClFO5
  • CLOGP: 4.21
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 77.51
  • ALOGS: -5.44
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Steroid withdrawal syndrome 100.70 39.95 16 1037 511 50603560
Skin exfoliation 91.51 39.95 32 1021 33580 50570491
Skin weeping 89.28 39.95 14 1039 410 50603661
Pruritus 57.25 39.95 47 1006 283521 50320550
Skin burning sensation 53.52 39.95 16 1037 10169 50593902

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Skin weeping 97.49 39.33 16 1367 608 64496741
Skin exfoliation 95.80 39.33 36 1347 44849 64452500
Steroid withdrawal syndrome 89.81 39.33 15 1368 635 64496714
Skin burning sensation 65.48 39.33 19 1364 10564 64486785
Rash 59.28 39.33 60 1323 458489 64038860
Pruritus 57.89 39.33 50 1333 312350 64184999
Skin wrinkling 39.43 39.33 8 1375 991 64496358

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AB01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC S01BA09 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01CA11 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Eczema indication 43116000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST KEGG DRUG KEGG DRUG

External reference:

IDSource
D01273 KEGG_DRUG
C0055896 UMLSCUI
CHEBI:31415 CHEBI
CHEMBL2308885 ChEMBL_ID
C010893 MESH_SUPPLEMENTAL_RECORD_UI
9088 IUPHAR_LIGAND_ID
54063-32-0 SECONDARY_CAS_RN
8U0H6XI6EO UNII
71386 PUBCHEM_CID
71387 PUBCHEM_CID
DB13158 DRUGBANK_ID
108074 RXNORM
003809 NDDF
003810 NDDF
116576003 SNOMEDCT_US
395963000 SNOMEDCT_US
395967004 SNOMEDCT_US
C0360518 UMLSCUI
3155 INN_ID
LT69WY1J6D UNII

Pharmaceutical products:

None