clobetasone butyrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3911 25122-57-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • eumovate
  • kindavate
  • clobetasone butyrate
  • 21-Chloro-11-dehydrobetamethasone
  • clobetasone 17-butyrate
  • Molecular weight: 478.99
  • Formula: C26H32ClFO5
  • CLOGP: 4.21
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 77.51
  • ALOGS: -5.44
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.680 Moderate 0.69
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.324 Moderate 0.69
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 74.302 10^-6 cm/s Moderate 0.69
dh-clint Dog hepatocyte intrinsic clearance 84.918 uL/min/10^6 cells Moderate 0.69
dppb Dog plasma protein binding (% unbound) 1.840 % Moderate 0.69
fcs-ppb Fetal calf serum protein binding (% unbound) 3.930 % Moderate 0.69
herg hERG pIC50 4.919 pIC50 Moderate 0.69
hh-clint Human hepatocyte intrinsic clearance 108.643 uL/min/10^6 cells Moderate 0.69
hlm-clint Human liver microsomal intrinsic clearance 236.592 uL/min/mg protein Moderate 0.69
hppb Human plasma protein binding (% unbound) 2.190 % Moderate 0.69
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,MAP2K6,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 42
kinase-selectivity-class AXL,GRK2,MAP2K6 3
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.328 Moderate 0.69
mh-clint Mouse hepatocyte intrinsic clearance 184.077 Moderate 0.69
mppb Mouse plasma protein binding (% unbound) 2.150 Moderate 0.69
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 8.072 Moderate 0.69
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 4.880 % Moderate 0.69
rh-clint Rat hepatocyte intrinsic clearance 152.055 uL/min/10^6 cells Moderate 0.69
rh-fuinc Rat hepatocyte fraction unbound in incubation 18.990 % Moderate 0.69
rppb Rat plasma protein binding (% unbound) 1.630 % Moderate 0.69
solubility-dd Solubility at pH 7.4 in DMSO 5.248 uM Moderate 0.69

Approvals:

DateAgencyCompanyOrphan
None PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Steroid withdrawal syndrome 95.98 33.71 16 1952 660 90625819
Skin weeping 73.29 33.71 16 1952 2784 90623695
Skin exfoliation 68.19 33.71 32 1936 67881 90558598
Skin burning sensation 42.51 33.71 16 1952 19595 90606884
Pruritus 35.98 33.71 51 1917 541474 90085005
Eczema 35.55 33.71 19 1949 52851 90573628
Catarrh 35.40 33.71 8 1960 1626 90624853
Medication error 34.55 33.71 22 1946 84630 90541849
Rash erythematous 34.49 33.71 20 1948 65084 90561395
Skin atrophy 34.37 33.71 10 1958 5519 90620960
Burns second degree 33.87 33.71 8 1960 1972 90624507

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Catarrh 236.75 105.71 63 3852 5923 42611497
Burns second degree 235.61 105.71 63 3852 6033 42611387
Steroid dependence 229.51 105.71 63 3852 6659 42610761
Parosmia 221.11 105.71 63 3852 7628 42609792
Hypopnoea 219.59 105.71 63 3852 7819 42609601
Gingival pain 219.35 105.71 64 3851 8430 42608990
Systemic lupus erythematosus 213.45 105.71 64 3851 9260 42608160
Rhinitis 193.60 105.71 63 3852 11914 42605506
Cardiac murmur 189.61 105.71 63 3852 12712 42604708
Impaired work ability 180.92 105.71 60 3855 12031 42605389
Swollen tongue 172.46 105.71 67 3848 21164 42596256
Bronchiectasis 172.07 105.71 64 3851 17955 42599465
Frequent bowel movements 164.86 105.71 65 3850 21342 42596078
Alcohol poisoning 164.75 105.71 50 3865 7524 42609896
Eczema 157.48 105.71 72 3843 34014 42583406
Colitis ulcerative 152.22 105.71 65 3850 26110 42591310
Impaired quality of life 148.80 105.71 54 3861 14123 42603297
Nightmare 148.38 105.71 63 3852 24949 42592471
Migraine 147.42 105.71 63 3852 25351 42592069
Tinnitus 145.95 105.71 65 3850 28873 42588547
Accidental overdose 144.05 105.71 64 3851 28266 42589154
Medication error 137.49 105.71 65 3850 33089 42584331
Tubulointerstitial nephritis 134.35 105.71 63 3852 31485 42585935
Dysgeusia 132.55 105.71 64 3851 34125 42583295
Vertigo 132.27 105.71 64 3851 34283 42583137
Stress 119.78 105.71 65 3850 44147 42573273
Palpitations 119.37 105.71 68 3847 50729 42566691
Arthritis 117.18 105.71 63 3852 42002 42575418
Rectal haemorrhage 112.78 105.71 65 3850 49541 42567879
Loss of personal independence in daily activities 109.87 105.71 64 3851 49752 42567668

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Catarrh 299.95 50.54 71 5757 7264 110576207
Burns second degree 296.22 50.54 71 5757 7662 110575809
Steroid dependence 289.80 50.54 71 5757 8398 110575073
Hypopnoea 268.98 50.54 71 5757 11309 110572162
Parosmia 258.65 50.54 71 5757 13109 110570362
Gingival pain 250.66 50.54 72 5756 15664 110567807
Rhinitis 221.02 50.54 71 5757 22474 110560997
Cardiac murmur 214.86 50.54 71 5757 24557 110558914
Bronchiectasis 198.48 50.54 74 5754 36419 110547052
Impaired work ability 198.20 50.54 68 5760 26351 110557120
Swollen tongue 194.73 50.54 84 5744 60278 110523193
Alcohol poisoning 192.84 50.54 52 5776 8968 110574503
Nightmare 186.77 50.54 72 5756 38791 110544680
Eczema 180.20 50.54 84 5744 72209 110511262
Impaired quality of life 167.34 50.54 62 5766 29955 110553516
Tubulointerstitial nephritis 166.76 50.54 73 5755 54211 110529260
Accidental overdose 163.44 50.54 71 5757 51763 110531708
Tinnitus 162.27 50.54 74 5754 60466 110523005
Medication error 150.27 50.54 84 5744 105282 110478189
Dysgeusia 149.03 50.54 73 5755 69912 110513559
Frequent bowel movements 147.65 50.54 73 5755 71317 110512154
Colitis ulcerative 145.00 50.54 74 5754 77289 110506182
Vertigo 139.72 50.54 75 5753 86795 110496676
Stress 121.02 50.54 73 5755 105275 110478196
Haematochezia 119.83 50.54 75 5753 115449 110468022
Rectal haemorrhage 112.37 50.54 73 5755 119760 110463711
Palpitations 109.23 50.54 80 5748 159132 110424339
Deep vein thrombosis 104.43 50.54 74 5754 139813 110443658
Loss of personal independence in daily activities 95.31 50.54 72 5756 149948 110433523
Arthritis 92.50 50.54 74 5754 167512 110415959
Cerebrovascular accident 85.35 50.54 73 5755 181211 110402260
Migraine 84.66 50.54 71 5757 171581 110411890
Adverse drug reaction 83.77 50.54 58 5770 105501 110477970
Inappropriate schedule of product administration 79.96 50.54 74 5754 203563 110379908
Rash 78.24 50.54 148 5680 820816 109762655
Pulmonary embolism 74.81 50.54 73 5755 214401 110369070
Steroid withdrawal syndrome 70.69 50.54 15 5813 930 110582541
COVID-19 64.93 50.54 72 5756 244988 110338483
Somnolence 64.79 50.54 79 5749 297370 110286101
Systemic lupus erythematosus 64.44 50.54 73 5755 254265 110329206
Intentional product use issue 62.54 50.54 71 5757 247835 110335636
Skin weeping 54.59 50.54 16 5812 3719 110579752
Depression 53.06 50.54 74 5754 317261 110266210

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AB01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC S01BA09 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01CA11 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Related Drugs by ATC class:

D07AB Corticosteroids, moderately potent (group II) 12 drugs
alclometasone dipropionateclocortolone pivalatedesonidedexamethasoneflumetasonefluocortin butylfluorometholonefluperolonefluprednidenehydrocortisone butyratehydrocortisone probutatetriamcinolone
S01BA Corticosteroids, plain 15 drugs
alclometasone dipropionatebetamethasoneclobetasol propionatedesonidedexamethasonedifluprednatefluocinolone acetonidefluorometholoneformocortalhydrocortisoneloteprednol etabonatemedrysone show all 15 →
S01CA Corticosteroids and antiinfectives in combination 11 drugs
betamethasonechloroprednisonedexamethasonefludrocortisone acetatefluocinolone acetonidefluocortolonefluorometholonehydrocortisoneloteprednol etabonatemethylprednisoloneprednisolone

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Eczema indication 43116000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST KEGG DRUG KEGG DRUG

External reference:

IDSource
D01273 KEGG_DRUG
C0055896 UMLSCUI
CHEBI:31415 CHEBI
CHEMBL2308885 ChEMBL_ID
C010893 MESH_SUPPLEMENTAL_RECORD_UI
8U0H6XI6EO UNII
71386 PUBCHEM_CID
DB13158 DRUGBANK_ID
108074 RXNORM
003809 NDDF
003810 NDDF
116576003 SNOMEDCT_US
395963000 SNOMEDCT_US
395967004 SNOMEDCT_US
C0360518 UMLSCUI
54063-32-0 SECONDARY_CAS_RN
71387 PUBCHEM_CID
9088 IUPHAR_LIGAND_ID
3155 INN_ID
LT69WY1J6D UNII
8U0H6XI6EO INXIGHT DRUGS
LT69WY1J6D INXIGHT DRUGS

Pharmaceutical products:

None