clobetasone butyrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3911 | 25122-57-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | PMDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Steroid withdrawal syndrome | 100.70 | 39.95 | 16 | 1037 | 511 | 50603560 |
| Skin exfoliation | 91.51 | 39.95 | 32 | 1021 | 33580 | 50570491 |
| Skin weeping | 89.28 | 39.95 | 14 | 1039 | 410 | 50603661 |
| Pruritus | 57.25 | 39.95 | 47 | 1006 | 283521 | 50320550 |
| Skin burning sensation | 53.52 | 39.95 | 16 | 1037 | 10169 | 50593902 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Skin weeping | 97.49 | 39.33 | 16 | 1367 | 608 | 64496741 |
| Skin exfoliation | 95.80 | 39.33 | 36 | 1347 | 44849 | 64452500 |
| Steroid withdrawal syndrome | 89.81 | 39.33 | 15 | 1368 | 635 | 64496714 |
| Skin burning sensation | 65.48 | 39.33 | 19 | 1364 | 10564 | 64486785 |
| Rash | 59.28 | 39.33 | 60 | 1323 | 458489 | 64038860 |
| Pruritus | 57.89 | 39.33 | 50 | 1333 | 312350 | 64184999 |
| Skin wrinkling | 39.43 | 39.33 | 8 | 1375 | 991 | 64496358 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D07AB01 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, moderately potent (group II) |
| ATC | S01BA09 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids, plain |
| ATC | S01CA11 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Atopic dermatitis | indication | 24079001 | DOID:3310 |
| Eczema | indication | 43116000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | KEGG DRUG | KEGG DRUG |
External reference:
| ID | Source |
|---|---|
| D01273 | KEGG_DRUG |
| C0055896 | UMLSCUI |
| CHEBI:31415 | CHEBI |
| CHEMBL2308885 | ChEMBL_ID |
| C010893 | MESH_SUPPLEMENTAL_RECORD_UI |
| 9088 | IUPHAR_LIGAND_ID |
| 54063-32-0 | SECONDARY_CAS_RN |
| 8U0H6XI6EO | UNII |
| 71386 | PUBCHEM_CID |
| 71387 | PUBCHEM_CID |
| DB13158 | DRUGBANK_ID |
| 108074 | RXNORM |
| 003809 | NDDF |
| 003810 | NDDF |
| 116576003 | SNOMEDCT_US |
| 395963000 | SNOMEDCT_US |
| 395967004 | SNOMEDCT_US |
| C0360518 | UMLSCUI |
| 3155 | INN_ID |
| LT69WY1J6D | UNII |
Pharmaceutical products:
None