fomepizole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1233 7554-65-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • homepizoru
  • fomepizole
  • 4-methylpyrazole
  • antizol
A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.
  • Molecular weight: 82.11
  • Formula: C4H6N2
  • CLOGP: 0.51
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 28.68
  • ALOGS: 0.83
  • ROTB: 0

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.35 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.73 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.42 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 4, 1997 FDA PALADIN LABS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V03AB34 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
FDA EPC N0000175429 Antidote
CHEBI has role CHEBI:50247 antidotes
CHEBI has role CHEBI:50267 protective agents
CHEBI has role CHEBI:50269 alcohol dehydrogenase inhibitors
MeSH PA D000931 Antidotes
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D020011 Protective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Accidental poisoning by methyl alcohol indication 216640006
Ethylene Glycol Toxicity indication
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Antidote for ethylene glycol (antifreeze) poisoning Indication

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.62 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alcohol dehydrogenase Enzyme INHIBITOR CHEMBL CHEMBL
Alcohol dehydrogenase Enzyme Kd 7.89 CHEMBL

External reference:

IDSource
83LCM6L2BY UNII
4021081 VUID
N0000148539 NUI
D00707 KEGG_DRUG
4021081 VANDF
C0048504 UMLSCUI
CHEBI:5141 CHEBI
4PZ PDB_CHEM_ID
CHEMBL1308 ChEMBL_ID
3406 PUBCHEM_CID
DB01213 DRUGBANK_ID
D000077604 MESH_DESCRIPTOR_UI
6633 INN_ID
11705 IUPHAR_LIGAND_ID
15226 RXNORM
11512 MMSL
130106 MMSL
4762 MMSL
d04274 MMSL
007238 NDDF
109100006 SNOMEDCT_US
386970006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
fomepizole HUMAN PRESCRIPTION DRUG LABEL 1 0517-0710 INJECTION, SOLUTION 1 g INTRAVENOUS ANDA 21 sections
fomepizole HUMAN PRESCRIPTION DRUG LABEL 1 0517-0710 INJECTION, SOLUTION 1 g INTRAVENOUS ANDA 21 sections
fomepizole Human Prescription Drug Label 1 0781-3182 INJECTION, SOLUTION 1 g INTRAVENOUS ANDA 18 sections
Antizol Human Prescription Drug Label 1 46129-200 INJECTION 1 g INTRAVENOUS NDA 19 sections
Fomepizole HUMAN PRESCRIPTION DRUG LABEL 1 67457-211 INJECTION, SOLUTION 1 g INTRAVENOUS ANDA 22 sections
Fomepizole HUMAN PRESCRIPTION DRUG LABEL 1 68475-510 INJECTION, SOLUTION 1 g INTRAVENOUS ANDA 11 sections
Fomepizole HUMAN PRESCRIPTION DRUG LABEL 1 70710-1478 INJECTION, SOLUTION 1 g INTRAVENOUS ANDA 11 sections