desonide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids for topical use, acetal derivatives 3135 638-94-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • desonide
  • budesonide acetonide
  • prednacinolone
A nonfluorinated corticosteroid anti-inflammatory agent used topically for DERMATOSES.
  • Molecular weight: 416.51
  • Formula: C24H32O6
  • CLOGP: 2.37
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 93.06
  • ALOGS: -3.85
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 4, 1972 FDA PERRIGO NEW YORK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 1119.94 25.29 280 4808 24096 63459838
Drug ineffective 244.55 25.29 352 4736 1044413 62439521
Chronic sinusitis 226.88 25.29 70 5018 12773 63471161
Paraesthesia oral 195.21 25.29 69 5019 19187 63464747
Procedural pain 187.57 25.29 69 5019 21500 63462434
Dermatitis atopic 154.93 25.29 49 5039 9675 63474259
Psoriasis 125.21 25.29 81 5007 86876 63397058
Vaginal flatulence 102.94 25.29 28 5060 3265 63480669
Dyspepsia 97.50 25.29 74 5014 102122 63381812
Proctitis 93.24 25.29 29 5059 5412 63478522
Therapeutic product effect incomplete 88.43 25.29 76 5012 124980 63358954
Radiculopathy 80.18 25.29 29 5059 8582 63475352
Female genital tract fistula 80.02 25.29 28 5060 7531 63476403
Vaginal discharge 78.31 25.29 29 5059 9169 63474765
Weight decreased 53.12 25.29 86 5002 276712 63207222
Oral candidiasis 53.07 25.29 29 5059 22769 63461165
Frequent bowel movements 52.81 25.29 29 5059 22993 63460941
Colitis ulcerative 52.08 25.29 30 5058 26061 63457873
Rectal haemorrhage 43.39 25.29 34 5054 48996 63434938
Cutaneous T-cell lymphoma 39.72 25.29 11 5077 1369 63482565
Nausea 39.20 25.29 153 4935 854318 62629616
Skin exfoliation 38.37 25.29 30 5058 43072 63440862
Infusion related reaction 37.49 25.29 69 5019 245452 63238482
Dry skin 36.96 25.29 33 5055 56854 63427080
Erythema 36.95 25.29 57 5031 175694 63308240
Haematochezia 34.66 25.29 31 5057 53513 63430421
Eczema 32.09 25.29 24 5064 32267 63451667
Colitis 31.22 25.29 28 5060 48500 63435434
Malaise 28.16 25.29 85 5003 415869 63068065
Iridoschisis 27.71 25.29 4 5084 14 63483920
Pyrexia 25.41 25.29 89 4999 470389 63013545

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Psoriasis 123.44 23.54 57 2234 38755 34915885
Dermatitis atopic 90.81 23.54 27 2264 5320 34949320
Dry skin 39.69 23.54 25 2266 31262 34923378
Drug ineffective 34.32 23.54 85 2206 456666 34497974
Pruritus 32.37 23.54 43 2248 141938 34812702
Product dose omission issue 31.60 23.54 39 2252 119672 34834968
Skin exfoliation 30.05 23.54 20 2271 27412 34927228
Hepatic lesion 27.43 23.54 10 2281 3702 34950938
Ocular hyperaemia 24.86 23.54 13 2278 11439 34943201

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 236.24 22.01 68 5502 11228 79727590
Chronic sinusitis 226.67 22.01 68 5502 12958 79725860
Paraesthesia oral 196.44 22.01 68 5502 20403 79718415
Procedural pain 188.45 22.01 68 5502 23016 79715802
Psoriasis 151.49 22.01 88 5482 89499 79649319
Dermatitis atopic 147.26 22.01 46 5524 10010 79728808
Vaginal flatulence 108.55 22.01 27 5543 2548 79736270
Dyspepsia 100.21 22.01 73 5497 108614 79630204
Therapeutic product effect incomplete 89.24 22.01 76 5494 141569 79597249
Female genital tract fistula 86.06 22.01 27 5543 5948 79732870
Vaginal discharge 84.13 22.01 28 5542 7435 79731383
Proctitis 84.10 22.01 27 5543 6405 79732413
Radiculopathy 75.73 22.01 27 5543 8797 79730021
Weight decreased 57.81 22.01 95 5475 355103 79383715
Oral candidiasis 52.36 22.01 30 5540 29598 79709220
Frequent bowel movements 49.78 22.01 29 5541 29510 79709308
Dry skin 47.97 22.01 39 5531 67956 79670862
Colitis ulcerative 47.94 22.01 30 5540 34712 79704106
Infusion related reaction 46.37 22.01 68 5502 230169 79508649
Cutaneous T-cell lymphoma 42.22 22.01 13 5557 2690 79736128
Rectal haemorrhage 42.07 22.01 38 5532 76262 79662556
Pruritus 39.72 22.01 86 5484 394562 79344256
Drug ineffective 36.32 22.01 160 5410 1080753 78658065
Pyrexia 32.95 22.01 113 5457 678596 79060222
Nausea 32.34 22.01 142 5428 957054 78781764
Product dose omission issue 32.11 22.01 60 5510 247477 79491341
Skin exfoliation 31.47 22.01 28 5542 55072 79683746
Pain 31.43 22.01 114 5456 703688 79035130
Malaise 29.61 22.01 88 5482 489781 79249037
Iridoschisis 28.26 22.01 4 5566 14 79738804
Application site pain 27.86 22.01 11 5559 4736 79734082
Erythema 27.56 22.01 53 5517 223237 79515581
Haematochezia 27.11 22.01 32 5538 87613 79651205
Eczema 25.84 22.01 22 5548 40796 79698022
Dry eye 25.65 22.01 21 5549 36910 79701908
Off label use 25.03 22.01 127 5443 907088 78831730
Colitis 24.74 22.01 28 5542 73279 79665539

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AB08 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC D07BB02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, moderately potent, combinations with antiseptics
ATC S01BA11 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Atopic dermatitis indication 24079001 DOID:3310
Crohn's disease indication 34000006
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Lichen simplex chronicus indication 53891004
Allergic rhinitis indication 61582004
Granuloma annulare indication 65508009 DOID:3777
Pruritus ani indication 90446007
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Scalp psoriasis indication 238608008
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Primary cutaneous T-cell lymphoma indication 400122007
Asthma management indication 406162001
Crohn's disease in remission indication 426549001
Allergic Rhinitis Prevention indication
Chronic Non-Allergic Rhinitis indication
Severe chronic obstructive pulmonary disease off-label use 313299006
Otitis Externa Eczema off-label use
Otitis Externa Seborrhea off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Epistaxis contraindication 12441001
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Disease caused by parasite contraindication 17322007
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Glaucoma contraindication 23986001 DOID:1686
Acute tuberculosis contraindication 25629007
Viral disease contraindication 34014006 DOID:934
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Hypercortisolism contraindication 47270006
Chronic heart failure contraindication 48447003
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Perforation of tympanic membrane contraindication 60442001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Perforation of nasal septum contraindication 80142000
Hyperglycemia contraindication 80394007 DOID:4195
Ornithine Carbamyltransferase Deficiency contraindication 80908008 DOID:9271
Open-angle glaucoma contraindication 84494001 DOID:1067
Bacterial infectious disease contraindication 87628006
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Operation on nose contraindication 88733004
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Pulmonary tuberculosis contraindication 154283005 DOID:2957
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Disease of liver contraindication 235856003 DOID:409
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Varicella-zoster virus infection contraindication 309465005
Osteopenia contraindication 312894000
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Nasal Candidiasis contraindication
Untreated Fungal Infection contraindication
Uncontrolled Bacterial Infections contraindication
Nasal Septal Ulcers contraindication
Nasal Trauma contraindication
Arginosuccinate Lyase Deficiency contraindication
Oropharyngeal Candidiasis contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.78 acidic
pKa2 12.78 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.05% VERDESO ALMIRALL N021978 Sept. 19, 2006 RX AEROSOL, FOAM TOPICAL 8962000 Aug. 31, 2025 TREATMENT OF ATOPIC DERMATITIS
0.05% VERDESO ALMIRALL N021978 Sept. 19, 2006 RX AEROSOL, FOAM TOPICAL 9492384 Aug. 31, 2025 TREATMENT OF ATOPIC DERMATITIS
0.05% VERDESO ALMIRALL N021978 Sept. 19, 2006 RX AEROSOL, FOAM TOPICAL 8460641 Aug. 13, 2027 TREATMENT OF ATOPIC DERMATITIS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
4018267 VUID
N0000146597 NUI
D03696 KEGG_DRUG
4018267 VANDF
C0011705 UMLSCUI
CHEBI:204734 CHEBI
CHEMBL1201109 ChEMBL_ID
D003898 MESH_DESCRIPTOR_UI
DB01260 DRUGBANK_ID
5311066 PUBCHEM_CID
7066 IUPHAR_LIGAND_ID
2889 INN_ID
J280872D1O UNII
3254 RXNORM
1093 MMSL
4550 MMSL
002199 NDDF
412363005 SNOMEDCT_US
52215008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 0115-1517 LOTION 0.50 mg TOPICAL ANDA 17 sections
desonide HUMAN PRESCRIPTION DRUG LABEL 1 0168-0309 OINTMENT 0.50 mg TOPICAL ANDA 17 sections
desonide HUMAN PRESCRIPTION DRUG LABEL 1 0168-0310 LOTION 0.50 mg TOPICAL ANDA 19 sections
DesOwen HUMAN PRESCRIPTION DRUG LABEL 1 0299-5765 LOTION 0.50 mg TOPICAL ANDA 18 sections
DesOwen HUMAN PRESCRIPTION DRUG LABEL 1 0299-5770 CREAM 0.50 mg TOPICAL NDA 18 sections
LoKara HUMAN PRESCRIPTION DRUG LABEL 1 0462-0392 LOTION 0.50 mg TOPICAL ANDA 18 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 0472-0803 LOTION 0.50 mg TOPICAL ANDA 19 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 0472-0804 CREAM 0.50 mg TOPICAL NDA authorized generic 19 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 0713-0661 CREAM 0.50 mg TOPICAL ANDA 18 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 0713-0661 CREAM 0.50 mg TOPICAL ANDA 18 sections
DESONATE HUMAN PRESCRIPTION DRUG LABEL 1 10922-828 GEL 0.50 mg TOPICAL NDA 24 sections
Verdeso HUMAN PRESCRIPTION DRUG LABEL 1 16110-111 AEROSOL, FOAM 0.50 mg TOPICAL NDA 26 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 16714-729 CREAM 0.50 mg TOPICAL ANDA 21 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 16714-729 CREAM 0.50 mg TOPICAL ANDA 21 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 16714-828 OINTMENT 0.50 mg TOPICAL ANDA 20 sections
DESONIDE HUMAN PRESCRIPTION DRUG LABEL 1 21695-944 CREAM 0.50 mg TOPICAL ANDA 21 sections
Desonide Ointment, 0.05% HUMAN PRESCRIPTION DRUG LABEL 1 21922-004 OINTMENT 0.50 mg TOPICAL ANDA 18 sections
DESONIDE HUMAN PRESCRIPTION DRUG LABEL 1 24470-920 GEL 0.50 mg TOPICAL ANDA 20 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 42254-142 CREAM 0.50 mg TOPICAL NDA 20 sections
DESRX HUMAN PRESCRIPTION DRUG LABEL 1 44118-710 GEL 0.50 mg TOPICAL ANDA 20 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 45802-422 CREAM 0.50 mg TOPICAL NDA 20 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 45802-422 CREAM 0.50 mg TOPICAL NDA 20 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 45802-423 OINTMENT 0.50 mg TOPICAL NDA 20 sections
DESONATE HUMAN PRESCRIPTION DRUG LABEL 1 50222-504 GEL 0.50 mg TOPICAL NDA 24 sections
DESONATE HUMAN PRESCRIPTION DRUG LABEL 1 50419-828 GEL 0.50 mg TOPICAL NDA 24 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 50436-3300 CREAM 0.50 mg TOPICAL ANDA 18 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 51672-1280 CREAM 0.50 mg TOPICAL ANDA 21 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 51672-1280 CREAM 0.50 mg TOPICAL ANDA 21 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 51672-1281 OINTMENT 0.50 mg TOPICAL ANDA 21 sections
Desonide HUMAN PRESCRIPTION DRUG LABEL 1 51672-1281 OINTMENT 0.50 mg TOPICAL ANDA 21 sections