Stem definition | Drug id | CAS RN |
---|---|---|
steroids for topical use, acetal derivatives | 3135 | 638-94-8 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 4, 1972 | FDA | PERRIGO NEW YORK |
None
None
Source | Code | Description |
---|---|---|
ATC | D07AB08 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, moderately potent (group II) |
ATC | D07BB02 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS Corticosteroids, moderately potent, combinations with antiseptics |
ATC | S01BA11 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids, plain |
FDA EPC | N0000175576 | Corticosteroid |
FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
MeSH PA | D000893 | Anti-Inflammatory Agents |
CHEBI has role | CHEBI:35472 | anti-inflammatory drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Otitis externa | indication | 3135009 | |
Atopic dermatitis | indication | 24079001 | DOID:3310 |
Crohn's disease | indication | 34000006 | |
Contact dermatitis | indication | 40275004 | DOID:2773 |
Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
Lichen simplex chronicus | indication | 53891004 | |
Allergic rhinitis | indication | 61582004 | |
Granuloma annulare | indication | 65508009 | DOID:3777 |
Pruritus ani | indication | 90446007 | |
Asthma | indication | 195967001 | DOID:2841 |
Discoid lupus erythematosus | indication | 200938002 | |
Plaque psoriasis | indication | 200965009 | |
Scalp psoriasis | indication | 238608008 | |
Pruritus of genital organs | indication | 267802000 | |
Eruption of skin | indication | 271807003 | DOID:0050486 |
Primary cutaneous T-cell lymphoma | indication | 400122007 | |
Asthma management | indication | 406162001 | |
Crohn's disease in remission | indication | 426549001 | |
Allergic Rhinitis Prevention | indication | ||
Chronic Non-Allergic Rhinitis | indication | ||
Severe chronic obstructive pulmonary disease | off-label use | 313299006 | |
Otitis Externa Eczema | off-label use | ||
Otitis Externa Seborrhea | off-label use | ||
Infection by Strongyloides | contraindication | 1214006 | DOID:10955 |
Mycosis | contraindication | 3218000 | DOID:1564 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Gastritis | contraindication | 4556007 | DOID:4029 |
Inactive tuberculosis | contraindication | 11999007 | |
Epistaxis | contraindication | 12441001 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Hypercholesterolemia | contraindication | 13644009 | |
Measles | contraindication | 14189004 | DOID:8622 |
Disease caused by parasite | contraindication | 17322007 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Arginase deficiency | contraindication | 23501004 | DOID:9278 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Acute tuberculosis | contraindication | 25629007 | |
Viral disease | contraindication | 34014006 | DOID:934 |
Immunosuppression | contraindication | 38013005 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Infectious disease | contraindication | 40733004 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Hypokalemia | contraindication | 43339004 | |
Hypercortisolism | contraindication | 47270006 | |
Chronic heart failure | contraindication | 48447003 | |
Cerebral malaria | contraindication | 53622003 | DOID:14069 |
Tuberculosis | contraindication | 56717001 | |
Perforation of tympanic membrane | contraindication | 60442001 | |
Congenital hyperammonemia, type I | contraindication | 62522004 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Psychotic disorder | contraindication | 69322001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hypopituitarism | contraindication | 74728003 | DOID:9406 |
Perforation of nasal septum | contraindication | 80142000 | |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Bacterial infectious disease | contraindication | 87628006 | |
Muscle atrophy | contraindication | 88092000 | DOID:767 |
Herpes simplex | contraindication | 88594005 | DOID:8566 |
Operation on nose | contraindication | 88733004 | |
Bilateral cataracts | contraindication | 95722004 | |
Seizure disorder | contraindication | 128613002 | |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Pulmonary tuberculosis | contraindication | 154283005 | DOID:2957 |
Ophthalmic herpes simplex | contraindication | 186542001 | |
Anastomosis of intestine | contraindication | 235407009 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Telangiectasia disorder | contraindication | 247479008 | |
Edema | contraindication | 267038008 | |
Pathological fracture | contraindication | 268029009 | |
Diverticulitis of gastrointestinal tract | contraindication | 271366000 | |
Cerebral trauma | contraindication | 275382005 | |
Varicella-zoster virus infection | contraindication | 309465005 | |
Osteopenia | contraindication | 312894000 | |
Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
Avascular necrosis of bone | contraindication | 397758007 | DOID:10159 |
Citrullinemia | contraindication | 398680004 | DOID:9273 |
Atrophoderma | contraindication | 399979006 | |
Peripheral vascular disease | contraindication | 400047006 | |
Traumatic rupture of tendon | contraindication | 415749005 | |
Exposure to varicella | contraindication | 444453009 | |
Nasal Candidiasis | contraindication | ||
Untreated Fungal Infection | contraindication | ||
Uncontrolled Bacterial Infections | contraindication | ||
Nasal Septal Ulcers | contraindication | ||
Ornithine Carbamyltransferase Deficiency | contraindication | ||
Nasal Trauma | contraindication | ||
Arginosuccinate Lyase Deficiency | contraindication | ||
Oropharyngeal Candidiasis | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.78 | acidic |
pKa2 | 12.78 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
0.05% | DESONATE | LEO PHARMA AS | N021844 | Oct. 20, 2006 | RX | GEL | TOPICAL | 6387383 | Aug. 3, 2020 | DESONATE GEL IS INDICATED FOR THE TREATMENT OF MILD TO MODERATE ATOPIC DERMATITIS IN PATIENTS 3 MONTHS OF AGE AND OLDER |
0.05% | VERDESO | ALMIRALL | N021978 | Sept. 19, 2006 | RX | AEROSOL, FOAM | TOPICAL | 8962000 | Aug. 31, 2025 | TREATMENT OF ATOPIC DERMATITIS |
0.05% | VERDESO | ALMIRALL | N021978 | Sept. 19, 2006 | RX | AEROSOL, FOAM | TOPICAL | 9492384 | Aug. 31, 2025 | TREATMENT OF ATOPIC DERMATITIS |
0.05% | VERDESO | ALMIRALL | N021978 | Sept. 19, 2006 | RX | AEROSOL, FOAM | TOPICAL | 8460641 | Aug. 13, 2027 | TREATMENT OF ATOPIC DERMATITIS |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
ID | Source |
---|---|
D003898 | MESH_DESCRIPTOR_UI |
4018267 | VUID |
N0000146597 | NUI |
C0011705 | UMLSCUI |
D03696 | KEGG_DRUG |
52215008 | SNOMEDCT_US |
4018267 | VANDF |
002199 | NDDF |
1093 | MMSL |
3254 | RXNORM |
412363005 | SNOMEDCT_US |
4550 | MMSL |
J280872D1O | UNII |
2889 | INN_ID |
DB01260 | DRUGBANK_ID |
CHEBI:204734 | CHEBI |
7066 | IUPHAR_LIGAND_ID |
CHEMBL1201109 | ChEMBL_ID |
5311066 | PUBCHEM_CID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1517 | LOTION | 0.50 mg | TOPICAL | ANDA | 11 sections |
desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0309 | OINTMENT | 0.50 mg | TOPICAL | ANDA | 11 sections |
desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0310 | LOTION | 0.50 mg | TOPICAL | ANDA | 11 sections |
DesOwen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0299-5765 | LOTION | 0.50 mg | TOPICAL | ANDA | 10 sections |
DesOwen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0299-5770 | CREAM | 0.50 mg | TOPICAL | NDA | 10 sections |
LoKara | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0462-0392 | LOTION | 0.50 mg | TOPICAL | ANDA | 11 sections |
DESONIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0472-0803 | LOTION | 0.50 mg | TOPICAL | ANDA | 19 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0472-0804 | CREAM | 0.50 mg | TOPICAL | NDA authorized generic | 10 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0661 | CREAM | 0.50 mg | TOPICAL | ANDA | 19 sections |
DESONATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10922-828 | GEL | 0.50 mg | TOPICAL | NDA | 15 sections |
Verdeso | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16110-111 | AEROSOL, FOAM | 0.50 mg | TOPICAL | NDA | 16 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-729 | CREAM | 0.50 mg | TOPICAL | ANDA | 11 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-828 | OINTMENT | 0.50 mg | TOPICAL | ANDA | 12 sections |
DESONIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-944 | CREAM | 0.50 mg | TOPICAL | ANDA | 11 sections |
Desonide Ointment, 0.05% | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21922-004 | OINTMENT | 0.50 mg | TOPICAL | ANDA | 10 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-142 | CREAM | 0.50 mg | TOPICAL | NDA | 12 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-422 | CREAM | 0.50 mg | TOPICAL | NDA | 12 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-423 | OINTMENT | 0.50 mg | TOPICAL | NDA | 12 sections |
DESONATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50222-504 | GEL | 0.50 mg | TOPICAL | NDA | 15 sections |
DESONATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50419-828 | GEL | 0.50 mg | TOPICAL | NDA | 15 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1280 | CREAM | 0.50 mg | TOPICAL | ANDA | 11 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1281 | OINTMENT | 0.50 mg | TOPICAL | ANDA | 11 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4079 | LOTION | 0.50 mg | TOPICAL | ANDA | 11 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52565-038 | OINTMENT | 0.50 mg | TOPICAL | ANDA | 12 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-3284 | CREAM | 0.50 mg | TOPICAL | NDA | 12 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4453 | OINTMENT | 0.50 mg | TOPICAL | NDA | 12 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5050 | LOTION | 0.50 mg | TOPICAL | ANDA | 19 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61748-470 | OINTMENT | 0.50 mg | TOPICAL | ANDA | 12 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62332-485 | OINTMENT | 0.50 mg | TOPICAL | ANDA | 11 sections |
Desonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63187-747 | CREAM | 0.50 mg | TOPICAL | NDA authorized generic | 9 sections |