cortivazol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 736 1110-40-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cortivazol
  • idaltim
  • Molecular weight: 530.67
  • Formula: C32H38N2O5
  • CLOGP: 5.32
  • LIPINSKI: 2
  • HAC: 7
  • HDO: 2
  • TPSA: 101.65
  • ALOGS: -5.21
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CG,PRKDC 17
kinase-selectivity-class GRK2,MAP2K6 2
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H02AB17 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:35480 analgesic

Related Drugs by ATC class:

H02AB Glucocorticoids 15 drugs
betamethasonecloprednoldeflazacortdexamethasonefluocortolonehydrocortisonemeprednisonemethylprednisoloneparamethasone acetateprednisoloneprednisoneprednylidene show all 15 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.83 acidic
pKa2 12.53 acidic
pKa3 0.93 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST KEGG DRUG KEGG DRUG

External reference:

IDSource
D03594 KEGG_DRUG
21660 RXNORM
C0056396 UMLSCUI
CHEBI:135820 CHEBI
CHEMBL2105842 ChEMBL_ID
DB13003 DRUGBANK_ID
C005924 MESH_SUPPLEMENTAL_RECORD_UI
2882 INN_ID
YM183K0H63 UNII
66249 PUBCHEM_CID
005797 NDDF
715389007 SNOMEDCT_US
YM183K0H63 INXIGHT DRUGS

Pharmaceutical products:

None