fluticasone propionate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids not used as glucocorticosteroids | 1225 | 80474-14-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A STEROID with GLUCOCORTICOID RECEPTOR activity that is used to manage the symptoms of ASTHMA; ALLERGIC RHINITIS, and ATOPIC DERMATITIS. It has received approval to be used in combination with salmeterol.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.20 | mg | N |
| 0.60 | mg | Inhal.aerosol |
| 0.60 | mg | Inhal.powder |
| 1.50 | mg | Inhal.solution |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.00 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 3 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 6.65 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 1 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 3.60 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 17 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.10 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 6 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 26, 2021 | EMA | TEVA B.V. | |
| Dec. 14, 1990 | FDA | FOUGERA PHARMS |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Asthma | 2733.84 | 9.84 | 2530 | 184654 | 89012 | 46409866 |
| Wheezing | 772.77 | 9.84 | 1010 | 186174 | 52376 | 46446502 |
| Dyspnoea | 591.40 | 9.84 | 3804 | 183380 | 511744 | 45987134 |
| Chronic obstructive pulmonary disease | 543.74 | 9.84 | 891 | 186293 | 56742 | 46442136 |
| Completed suicide | 527.29 | 9.84 | 12 | 187172 | 145908 | 46352970 |
| Cough | 411.06 | 9.84 | 1919 | 185265 | 228330 | 46270548 |
| Toxicity to various agents | 394.17 | 9.84 | 178 | 187006 | 211588 | 46287290 |
| Obstructive airways disorder | 335.48 | 9.84 | 337 | 186847 | 13075 | 46485803 |
| Sinusitis | 297.93 | 9.84 | 1168 | 186016 | 128600 | 46370278 |
| Productive cough | 288.53 | 9.84 | 632 | 186552 | 50083 | 46448795 |
| Forced expiratory volume decreased | 285.64 | 9.84 | 204 | 186980 | 4900 | 46493978 |
| Infective pulmonary exacerbation of cystic fibrosis | 278.51 | 9.84 | 276 | 186908 | 10531 | 46488347 |
| Bronchitis | 254.70 | 9.84 | 968 | 186216 | 105011 | 46393867 |
| Sputum discoloured | 250.34 | 9.84 | 282 | 186902 | 12496 | 46486382 |
| Chest discomfort | 245.18 | 9.84 | 858 | 186326 | 89411 | 46409467 |
| Pneumonia | 218.84 | 9.84 | 2387 | 184797 | 373933 | 46124945 |
| Product quality issue | 207.00 | 9.84 | 448 | 186736 | 35200 | 46463678 |
| Eosinophilic granulomatosis with polyangiitis | 184.11 | 9.84 | 106 | 187078 | 1730 | 46497148 |
| Drug abuse | 178.54 | 9.84 | 22 | 187162 | 63386 | 46435492 |
| Neutropenia | 176.67 | 9.84 | 188 | 186996 | 143016 | 46355862 |
| Synovitis | 170.00 | 9.84 | 22 | 187162 | 61053 | 46437825 |
| Upper respiratory tract infection | 169.82 | 9.84 | 601 | 186583 | 62955 | 46435923 |
| Nasal congestion | 161.79 | 9.84 | 492 | 186692 | 47621 | 46451257 |
| Intentional overdose | 151.33 | 9.84 | 37 | 187147 | 64907 | 46433971 |
| Rheumatoid arthritis | 146.01 | 9.84 | 485 | 186699 | 239730 | 46259148 |
| Febrile neutropenia | 142.31 | 9.84 | 103 | 187081 | 94524 | 46404354 |
| Off label use | 136.69 | 9.84 | 927 | 186257 | 378914 | 46119964 |
| Treatment failure | 136.53 | 9.84 | 104 | 187080 | 92983 | 46405895 |
| Blood count abnormal | 131.58 | 9.84 | 248 | 186936 | 17630 | 46481248 |
| Thrombocytopenia | 124.35 | 9.84 | 197 | 186987 | 126384 | 46372494 |
| Nasal polyps | 122.90 | 9.84 | 88 | 187096 | 2122 | 46496756 |
| Food allergy | 119.05 | 9.84 | 143 | 187041 | 6790 | 46492088 |
| Temperature regulation disorder | 117.98 | 9.84 | 102 | 187082 | 3258 | 46495620 |
| Pancytopenia | 114.87 | 9.84 | 103 | 187081 | 84955 | 46413923 |
| Contraindicated product administered | 110.14 | 9.84 | 95 | 187089 | 79852 | 46419026 |
| Pulmonary function test decreased | 106.74 | 9.84 | 102 | 187082 | 3718 | 46495160 |
| Systemic lupus erythematosus | 106.00 | 9.84 | 65 | 187119 | 65115 | 46433763 |
| Drug ineffective | 105.21 | 9.84 | 2002 | 185182 | 675836 | 45823042 |
| Dyspnoea exertional | 99.72 | 9.84 | 433 | 186751 | 49856 | 46449022 |
| Influenza | 98.99 | 9.84 | 655 | 186529 | 88615 | 46410263 |
| Dysphonia | 98.09 | 9.84 | 358 | 186826 | 38056 | 46460822 |
| Drug intolerance | 96.21 | 9.84 | 287 | 186897 | 146762 | 46352116 |
| Hand deformity | 94.90 | 9.84 | 13 | 187171 | 34561 | 46464317 |
| Malignant neoplasm progression | 94.60 | 9.84 | 73 | 187111 | 64853 | 46434025 |
| Seasonal allergy | 89.61 | 9.84 | 178 | 187006 | 13156 | 46485722 |
| Coeliac disease | 87.61 | 9.84 | 125 | 187059 | 7036 | 46491842 |
| Middle insomnia | 86.79 | 9.84 | 145 | 187039 | 9370 | 46489508 |
| Coma | 85.78 | 9.84 | 65 | 187119 | 58284 | 46440594 |
| Rhinitis allergic | 85.13 | 9.84 | 121 | 187063 | 6787 | 46492091 |
| Cardio-respiratory arrest | 85.10 | 9.84 | 69 | 187115 | 59800 | 46439078 |
| Leukopenia | 85.02 | 9.84 | 89 | 187095 | 68254 | 46430624 |
| Death | 82.86 | 9.84 | 903 | 186281 | 334645 | 46164233 |
| Drug interaction | 81.96 | 9.84 | 478 | 186706 | 202616 | 46296262 |
| Respiratory tract congestion | 79.37 | 9.84 | 165 | 187019 | 12599 | 46486279 |
| Adrenal suppression | 77.39 | 9.84 | 48 | 187136 | 903 | 46497975 |
| Rhinorrhoea | 74.47 | 9.84 | 383 | 186801 | 47282 | 46451596 |
| Maternal exposure during pregnancy | 73.85 | 9.84 | 191 | 186993 | 102358 | 46396520 |
| Fluid retention | 73.48 | 9.84 | 401 | 186783 | 50645 | 46448233 |
| Hypersensitivity | 73.37 | 9.84 | 923 | 186261 | 149398 | 46349480 |
| Anaemia | 73.25 | 9.84 | 664 | 186520 | 255115 | 46243763 |
| Blood immunoglobulin E increased | 72.97 | 9.84 | 59 | 187125 | 1714 | 46497164 |
| Oropharyngeal pain | 72.07 | 9.84 | 527 | 186657 | 73641 | 46425237 |
| Immunodeficiency | 71.85 | 9.84 | 161 | 187023 | 12945 | 46485933 |
| Breath sounds abnormal | 71.15 | 9.84 | 119 | 187065 | 7696 | 46491182 |
| Joint swelling | 70.70 | 9.84 | 384 | 186800 | 165689 | 46333189 |
| Multiple organ dysfunction syndrome | 70.54 | 9.84 | 62 | 187122 | 51648 | 46447230 |
| Alopecia | 69.99 | 9.84 | 374 | 186810 | 162040 | 46336838 |
| Cystic fibrosis | 68.18 | 9.84 | 79 | 187105 | 3609 | 46495269 |
| Sleep apnoea syndrome | 67.22 | 9.84 | 219 | 186965 | 21982 | 46476896 |
| Sputum increased | 67.17 | 9.84 | 56 | 187128 | 1700 | 46497178 |
| Hepatic function abnormal | 66.99 | 9.84 | 27 | 187157 | 34394 | 46464484 |
| Sleep disorder due to a general medical condition | 66.45 | 9.84 | 76 | 187108 | 3423 | 46495455 |
| Product dose omission issue | 66.05 | 9.84 | 995 | 186189 | 167525 | 46331353 |
| Glossodynia | 65.77 | 9.84 | 49 | 187135 | 44324 | 46454554 |
| Hepatotoxicity | 64.98 | 9.84 | 11 | 187173 | 24998 | 46473880 |
| Drug reaction with eosinophilia and systemic symptoms | 64.72 | 9.84 | 19 | 187165 | 29529 | 46469349 |
| Emphysema | 64.65 | 9.84 | 124 | 187060 | 8930 | 46489948 |
| Acute kidney injury | 64.62 | 9.84 | 619 | 186565 | 235236 | 46263642 |
| Peak expiratory flow rate decreased | 64.58 | 9.84 | 37 | 187147 | 598 | 46498280 |
| Gastrooesophageal reflux disease | 63.18 | 9.84 | 512 | 186672 | 73832 | 46425046 |
| Mucosal inflammation | 63.18 | 9.84 | 39 | 187145 | 38937 | 46459941 |
| Malaise | 61.36 | 9.84 | 1750 | 185434 | 329482 | 46169396 |
| Nasopharyngitis | 60.23 | 9.84 | 909 | 186275 | 153089 | 46345789 |
| Upper-airway cough syndrome | 59.17 | 9.84 | 110 | 187074 | 7737 | 46491141 |
| Suicide attempt | 57.54 | 9.84 | 82 | 187102 | 54954 | 46443924 |
| Overdose | 57.08 | 9.84 | 213 | 186971 | 101766 | 46397112 |
| Gamma-glutamyltransferase increased | 56.89 | 9.84 | 28 | 187156 | 31712 | 46467166 |
| Eosinophil count increased | 56.50 | 9.84 | 108 | 187076 | 7758 | 46491120 |
| Therapeutic product effect decreased | 56.33 | 9.84 | 158 | 187026 | 82443 | 46416435 |
| Platelet count decreased | 55.93 | 9.84 | 209 | 186975 | 99815 | 46399063 |
| Headache | 55.57 | 9.84 | 2395 | 184789 | 475957 | 46022921 |
| Respiratory symptom | 55.44 | 9.84 | 54 | 187130 | 2016 | 46496862 |
| Cardiac arrest | 54.47 | 9.84 | 183 | 187001 | 90216 | 46408662 |
| Asthmatic crisis | 54.20 | 9.84 | 46 | 187138 | 1432 | 46497446 |
| Arthropathy | 54.15 | 9.84 | 167 | 187017 | 84533 | 46414345 |
| Adrenal insufficiency | 53.61 | 9.84 | 144 | 187040 | 12980 | 46485898 |
| Chronic sinusitis | 53.16 | 9.84 | 82 | 187102 | 4951 | 46493927 |
| Exposure during pregnancy | 52.46 | 9.84 | 239 | 186945 | 107973 | 46390905 |
| Bone marrow failure | 51.94 | 9.84 | 27 | 187157 | 29642 | 46469236 |
| Eye pruritus | 51.09 | 9.84 | 133 | 187051 | 11765 | 46487113 |
| Inhalation therapy | 49.90 | 9.84 | 16 | 187168 | 50 | 46498828 |
| Bursitis | 49.03 | 9.84 | 183 | 187001 | 19659 | 46479219 |
| Haemoptysis | 48.50 | 9.84 | 221 | 186963 | 25968 | 46472910 |
| Sinus disorder | 47.13 | 9.84 | 160 | 187024 | 16403 | 46482475 |
| Sopor | 46.76 | 9.84 | 11 | 187173 | 19817 | 46479061 |
| Oxygen saturation decreased | 46.71 | 9.84 | 453 | 186731 | 68711 | 46430167 |
| Prolonged expiration | 46.35 | 9.84 | 25 | 187159 | 357 | 46498521 |
| Sneezing | 46.33 | 9.84 | 134 | 187050 | 12607 | 46486271 |
| Respiratory arrest | 45.57 | 9.84 | 41 | 187143 | 33775 | 46465103 |
| Rhinitis | 45.46 | 9.84 | 99 | 187085 | 7807 | 46491071 |
| C-reactive protein increased | 45.41 | 9.84 | 105 | 187079 | 58485 | 46440393 |
| Cytomegalovirus infection | 44.95 | 9.84 | 9 | 187175 | 18135 | 46480743 |
| Acute respiratory failure | 44.71 | 9.84 | 233 | 186951 | 28905 | 46469973 |
| Lung disorder | 44.54 | 9.84 | 312 | 186872 | 42992 | 46455886 |
| Hypotension | 43.91 | 9.84 | 662 | 186522 | 231927 | 46266951 |
| Agranulocytosis | 43.83 | 9.84 | 17 | 187167 | 22168 | 46476710 |
| Viral infection | 43.82 | 9.84 | 238 | 186946 | 29997 | 46468881 |
| Forced vital capacity decreased | 43.42 | 9.84 | 33 | 187151 | 874 | 46498004 |
| Heart rate increased | 42.52 | 9.84 | 473 | 186711 | 74318 | 46424560 |
| Nasal discomfort | 42.46 | 9.84 | 63 | 187121 | 3675 | 46495203 |
| Neutrophil count decreased | 42.21 | 9.84 | 68 | 187116 | 43358 | 46455520 |
| Pulmonary mass | 41.90 | 9.84 | 162 | 187022 | 17695 | 46481183 |
| Serotonin syndrome | 41.00 | 9.84 | 23 | 187161 | 24197 | 46474681 |
| Respiratory tract infection | 40.16 | 9.84 | 231 | 186953 | 29741 | 46469137 |
| Pericarditis | 40.10 | 9.84 | 23 | 187161 | 23904 | 46474974 |
| Infusion related reaction | 39.81 | 9.84 | 240 | 186944 | 100968 | 46397910 |
| Dizziness | 39.78 | 9.84 | 1706 | 185478 | 338708 | 46160170 |
| Alanine aminotransferase increased | 39.57 | 9.84 | 201 | 186983 | 88250 | 46410628 |
| General physical health deterioration | 38.79 | 9.84 | 288 | 186896 | 115481 | 46383397 |
| Bradycardia | 38.72 | 9.84 | 136 | 187048 | 66162 | 46432716 |
| Hyperkalaemia | 38.39 | 9.84 | 92 | 187092 | 50617 | 46448261 |
| Foetal exposure during pregnancy | 38.27 | 9.84 | 40 | 187144 | 30707 | 46468171 |
| Lactic acidosis | 38.00 | 9.84 | 48 | 187136 | 33861 | 46465017 |
| Toxic epidermal necrolysis | 37.93 | 9.84 | 21 | 187163 | 22257 | 46476621 |
| Aphonia | 37.44 | 9.84 | 92 | 187092 | 7853 | 46491025 |
| Bronchial wall thickening | 37.08 | 9.84 | 29 | 187155 | 802 | 46498076 |
| Lower respiratory tract infection | 36.79 | 9.84 | 360 | 186824 | 54729 | 46444149 |
| Chest pain | 36.65 | 9.84 | 946 | 186238 | 175378 | 46323500 |
| Osteonecrosis of jaw | 36.21 | 9.84 | 51 | 187133 | 34351 | 46464527 |
| Renal impairment | 36.19 | 9.84 | 164 | 187020 | 74208 | 46424670 |
| Metabolic acidosis | 35.59 | 9.84 | 63 | 187121 | 38717 | 46460161 |
| Renal failure | 35.53 | 9.84 | 288 | 186896 | 113306 | 46385572 |
| Hypoventilation | 35.32 | 9.84 | 61 | 187123 | 4049 | 46494829 |
| Hepatocellular injury | 34.99 | 9.84 | 40 | 187144 | 29482 | 46469396 |
| Anxiety | 34.89 | 9.84 | 966 | 186218 | 180991 | 46317887 |
| Increased viscosity of bronchial secretion | 34.70 | 9.84 | 19 | 187165 | 280 | 46498598 |
| Aspartate aminotransferase increased | 34.55 | 9.84 | 180 | 187004 | 78520 | 46420358 |
| Poisoning | 34.55 | 9.84 | 7 | 187177 | 13987 | 46484891 |
| Therapeutic product effect incomplete | 33.96 | 9.84 | 470 | 186714 | 77683 | 46421195 |
| Throat irritation | 33.80 | 9.84 | 215 | 186969 | 28686 | 46470192 |
| Septic shock | 33.65 | 9.84 | 119 | 187065 | 57774 | 46441104 |
| Secretion discharge | 33.56 | 9.84 | 97 | 187087 | 9122 | 46489756 |
| Peritonitis | 33.19 | 9.84 | 21 | 187163 | 20693 | 46478185 |
| Asthma-chronic obstructive pulmonary disease overlap syndrome | 33.15 | 9.84 | 22 | 187162 | 467 | 46498411 |
| Pneumocystis jirovecii pneumonia | 33.04 | 9.84 | 10 | 187174 | 15238 | 46483640 |
| Intentional self-injury | 32.92 | 9.84 | 29 | 187155 | 24137 | 46474741 |
| Bronchial obstruction | 32.65 | 9.84 | 33 | 187151 | 1289 | 46497589 |
| Bronchiectasis | 31.98 | 9.84 | 96 | 187088 | 9220 | 46489658 |
| Feeling abnormal | 31.80 | 9.84 | 690 | 186494 | 124370 | 46374508 |
| Increased upper airway secretion | 31.52 | 9.84 | 51 | 187133 | 3208 | 46495670 |
| Product use in unapproved indication | 31.48 | 9.84 | 222 | 186962 | 90051 | 46408827 |
| Eosinophil count abnormal | 31.47 | 9.84 | 21 | 187163 | 450 | 46498428 |
| Pulmonary function test abnormal | 31.39 | 9.84 | 32 | 187152 | 1263 | 46497615 |
| Blood lactate dehydrogenase increased | 31.21 | 9.84 | 22 | 187162 | 20478 | 46478400 |
| Depressed level of consciousness | 30.95 | 9.84 | 93 | 187091 | 47476 | 46451402 |
| Premature baby | 30.94 | 9.84 | 17 | 187167 | 18095 | 46480783 |
| Sinus congestion | 30.82 | 9.84 | 119 | 187065 | 12990 | 46485888 |
| Ear infection | 30.59 | 9.84 | 177 | 187007 | 22836 | 46476042 |
| Bronchospasm | 30.17 | 9.84 | 134 | 187050 | 15573 | 46483305 |
| Blood creatinine increased | 30.14 | 9.84 | 181 | 187003 | 76222 | 46422656 |
| Cushing's syndrome | 30.07 | 9.84 | 25 | 187159 | 756 | 46498122 |
| Status asthmaticus | 30.03 | 9.84 | 27 | 187157 | 909 | 46497969 |
| Palmar-plantar erythrodysaesthesia syndrome | 29.77 | 9.84 | 23 | 187161 | 20428 | 46478450 |
| Neurotoxicity | 29.71 | 9.84 | 9 | 187175 | 13708 | 46485170 |
| Hyponatraemia | 29.40 | 9.84 | 262 | 186922 | 101070 | 46397808 |
| Otorrhoea | 29.13 | 9.84 | 32 | 187152 | 1378 | 46497500 |
| Aspirin-exacerbated respiratory disease | 28.91 | 9.84 | 24 | 187160 | 724 | 46498154 |
| Rash erythematous | 28.86 | 9.84 | 236 | 186948 | 34114 | 46464764 |
| Smoke sensitivity | 28.51 | 9.84 | 16 | 187168 | 248 | 46498630 |
| Bone erosion | 28.45 | 9.84 | 93 | 187091 | 9350 | 46489528 |
| Cor pulmonale | 28.44 | 9.84 | 37 | 187147 | 1906 | 46496972 |
| Drug hypersensitivity | 28.44 | 9.84 | 752 | 186432 | 243073 | 46255805 |
| Wound | 28.34 | 9.84 | 83 | 187101 | 42719 | 46456159 |
| Reversible airways obstruction | 28.33 | 9.84 | 21 | 187163 | 535 | 46498343 |
| Musculoskeletal stiffness | 28.15 | 9.84 | 254 | 186930 | 97739 | 46401139 |
| Weight increased | 27.91 | 9.84 | 860 | 186324 | 163613 | 46335265 |
| Posterior reversible encephalopathy syndrome | 27.68 | 9.84 | 13 | 187171 | 15128 | 46483750 |
| Shock | 27.66 | 9.84 | 28 | 187156 | 21817 | 46477061 |
| Infusion site erythema | 27.42 | 9.84 | 80 | 187104 | 7562 | 46491316 |
| Disease progression | 27.40 | 9.84 | 234 | 186950 | 91066 | 46407812 |
| Rales | 27.37 | 9.84 | 93 | 187091 | 9538 | 46489340 |
| Palpitations | 27.30 | 9.84 | 535 | 186649 | 94724 | 46404154 |
| Hospitalisation | 27.05 | 9.84 | 380 | 186804 | 63005 | 46435873 |
| Spirometry abnormal | 26.84 | 9.84 | 14 | 187170 | 186 | 46498692 |
| Throat clearing | 26.49 | 9.84 | 18 | 187166 | 398 | 46498480 |
| Urticaria | 26.40 | 9.84 | 639 | 186545 | 117253 | 46381625 |
| Cholestasis | 26.24 | 9.84 | 42 | 187142 | 26851 | 46472027 |
| Eosinophilic oesophagitis | 26.14 | 9.84 | 14 | 187170 | 197 | 46498681 |
| Rhonchi | 26.12 | 9.84 | 38 | 187146 | 2177 | 46496701 |
| Bronchial disorder | 25.86 | 9.84 | 26 | 187158 | 1009 | 46497869 |
| Hepatic failure | 25.79 | 9.84 | 60 | 187124 | 33356 | 46465522 |
| Cortisol decreased | 25.67 | 9.84 | 26 | 187158 | 1018 | 46497860 |
| Ectropion | 25.58 | 9.84 | 13 | 187171 | 163 | 46498715 |
| Asphyxia | 25.44 | 9.84 | 62 | 187122 | 5264 | 46493614 |
| Product complaint | 25.37 | 9.84 | 106 | 187078 | 11995 | 46486883 |
| Paranasal sinus discomfort | 25.20 | 9.84 | 41 | 187143 | 2591 | 46496287 |
| Altered state of consciousness | 25.19 | 9.84 | 34 | 187150 | 23314 | 46475564 |
| Rhabdomyolysis | 25.12 | 9.84 | 85 | 187099 | 41824 | 46457054 |
| Circulatory collapse | 24.87 | 9.84 | 30 | 187154 | 21594 | 46477284 |
| Acute generalised exanthematous pustulosis | 24.74 | 9.84 | 4 | 187180 | 9401 | 46489477 |
| Rectal prolapse | 24.72 | 9.84 | 31 | 187153 | 1539 | 46497339 |
| Anosmia | 24.54 | 9.84 | 51 | 187133 | 3893 | 46494985 |
| Abortion spontaneous | 24.51 | 9.84 | 91 | 187093 | 43555 | 46455323 |
| Migraine | 24.19 | 9.84 | 405 | 186779 | 69621 | 46429257 |
| Mite allergy | 23.95 | 9.84 | 17 | 187167 | 404 | 46498474 |
| Sinus headache | 23.84 | 9.84 | 56 | 187128 | 4644 | 46494234 |
| Dermatitis allergic | 23.82 | 9.84 | 107 | 187077 | 12496 | 46486382 |
| Metastases to liver | 23.79 | 9.84 | 26 | 187158 | 19559 | 46479319 |
| Metastases to bone | 23.77 | 9.84 | 21 | 187163 | 17455 | 46481423 |
| Respiratory disorder | 23.71 | 9.84 | 189 | 186995 | 27111 | 46471767 |
| Cardiac failure | 23.50 | 9.84 | 206 | 186978 | 79742 | 46419136 |
| Drug resistance | 23.47 | 9.84 | 21 | 187163 | 17347 | 46481531 |
| Acute sinusitis | 23.35 | 9.84 | 50 | 187134 | 3897 | 46494981 |
| Device expulsion | 23.29 | 9.84 | 47 | 187137 | 27495 | 46471383 |
| Humidity intolerance | 23.00 | 9.84 | 16 | 187168 | 368 | 46498510 |
| Jaundice | 22.91 | 9.84 | 51 | 187133 | 28794 | 46470084 |
| Total lung capacity abnormal | 22.87 | 9.84 | 8 | 187176 | 35 | 46498843 |
| Dust allergy | 22.65 | 9.84 | 18 | 187166 | 510 | 46498368 |
| Acute myeloid leukaemia | 22.64 | 9.84 | 18 | 187166 | 15760 | 46483118 |
| Pneumonia aspiration | 22.63 | 9.84 | 59 | 187125 | 31546 | 46467332 |
| Multiple allergies | 22.57 | 9.84 | 73 | 187111 | 7298 | 46491580 |
| Increased bronchial secretion | 22.49 | 9.84 | 30 | 187154 | 1584 | 46497294 |
| Pruritus | 22.19 | 9.84 | 1186 | 185998 | 241166 | 46257712 |
| Stevens-Johnson syndrome | 22.15 | 9.84 | 37 | 187147 | 23260 | 46475618 |
| Drug eruption | 22.07 | 9.84 | 32 | 187152 | 21297 | 46477581 |
| Lower respiratory tract congestion | 22.05 | 9.84 | 32 | 187152 | 1829 | 46497049 |
| Seizure | 21.91 | 9.84 | 354 | 186830 | 122700 | 46376178 |
| Sinusitis fungal | 21.84 | 9.84 | 22 | 187162 | 856 | 46498022 |
| Atopy | 21.79 | 9.84 | 12 | 187172 | 179 | 46498699 |
| Pulmonary pain | 21.61 | 9.84 | 30 | 187154 | 1646 | 46497232 |
| Sputum retention | 21.57 | 9.84 | 16 | 187168 | 408 | 46498470 |
| Lung hyperinflation | 21.54 | 9.84 | 25 | 187159 | 1144 | 46497734 |
| Hypothermia | 21.45 | 9.84 | 11 | 187173 | 12172 | 46486706 |
| Laryngitis | 21.43 | 9.84 | 84 | 187100 | 9232 | 46489646 |
| Transplant rejection | 21.33 | 9.84 | 6 | 187178 | 9590 | 46489288 |
| Respiratory tract irritation | 21.17 | 9.84 | 16 | 187168 | 420 | 46498458 |
| Perfume sensitivity | 21.06 | 9.84 | 18 | 187166 | 566 | 46498312 |
| Bronchopulmonary aspergillosis allergic | 20.99 | 9.84 | 20 | 187164 | 726 | 46498152 |
| Injury | 20.87 | 9.84 | 269 | 186915 | 43758 | 46455120 |
| Muscle rigidity | 20.75 | 9.84 | 7 | 187177 | 9954 | 46488924 |
| Dyskinesia | 20.71 | 9.84 | 54 | 187130 | 28871 | 46470007 |
| Eosinophilic pneumonia chronic | 20.70 | 9.84 | 9 | 187175 | 77 | 46498801 |
| Salpingo-oophorectomy unilateral | 20.69 | 9.84 | 15 | 187169 | 369 | 46498509 |
| Emotional distress | 20.66 | 9.84 | 201 | 186983 | 30506 | 46468372 |
| Sepsis | 20.50 | 9.84 | 403 | 186781 | 135611 | 46363267 |
| Illness | 20.33 | 9.84 | 100 | 187084 | 12124 | 46486754 |
| Nasal mucosal disorder | 20.21 | 9.84 | 15 | 187169 | 383 | 46498495 |
| Disseminated intravascular coagulation | 20.17 | 9.84 | 28 | 187156 | 18977 | 46479901 |
| Anaphylactic reaction | 20.14 | 9.84 | 312 | 186872 | 52800 | 46446078 |
| Hyposmia | 20.07 | 9.84 | 15 | 187169 | 387 | 46498491 |
| Helicobacter infection | 20.07 | 9.84 | 11 | 187173 | 11725 | 46487153 |
| Weight decreased | 19.93 | 9.84 | 1035 | 186149 | 209814 | 46289064 |
| Bronchitis bacterial | 19.87 | 9.84 | 19 | 187165 | 693 | 46498185 |
| Pre-existing condition improved | 19.81 | 9.84 | 65 | 187119 | 6547 | 46492331 |
| Neoplasm progression | 19.73 | 9.84 | 49 | 187135 | 26634 | 46472244 |
| Liver injury | 19.71 | 9.84 | 21 | 187163 | 15980 | 46482898 |
| Accidental exposure to product | 19.57 | 9.84 | 34 | 187150 | 21047 | 46477831 |
| Cerebral haemorrhage | 19.53 | 9.84 | 54 | 187130 | 28317 | 46470561 |
| Rheumatoid nodule | 19.39 | 9.84 | 6 | 187178 | 9014 | 46489864 |
| Nocturnal dyspnoea | 19.27 | 9.84 | 22 | 187162 | 989 | 46497889 |
| Nasal turbinate hypertrophy | 19.21 | 9.84 | 15 | 187169 | 414 | 46498464 |
| Influenza B virus test positive | 19.05 | 9.84 | 14 | 187170 | 352 | 46498526 |
| Oral candidiasis | 19.02 | 9.84 | 128 | 187056 | 17404 | 46481474 |
| Poor quality device used | 19.01 | 9.84 | 32 | 187152 | 2080 | 46496798 |
| Bronchospasm paradoxical | 18.90 | 9.84 | 9 | 187175 | 97 | 46498781 |
| Cerebral infarction | 18.81 | 9.84 | 41 | 187143 | 23325 | 46475553 |
| Bladder prolapse | 18.81 | 9.84 | 30 | 187154 | 1864 | 46497014 |
| Influenza like illness | 18.81 | 9.84 | 330 | 186854 | 57240 | 46441638 |
| Neurosensory hypoacusis | 18.80 | 9.84 | 13 | 187171 | 296 | 46498582 |
| Haemodynamic instability | 18.79 | 9.84 | 4 | 187180 | 7721 | 46491157 |
| Candida infection | 18.79 | 9.84 | 153 | 187031 | 22087 | 46476791 |
| Blood bilirubin increased | 18.72 | 9.84 | 72 | 187112 | 34112 | 46464766 |
| Blood pressure systolic increased | 18.67 | 9.84 | 187 | 186997 | 28600 | 46470278 |
| Respiratory rate increased | 18.64 | 9.84 | 93 | 187091 | 11340 | 46487538 |
| White blood cell count decreased | 18.63 | 9.84 | 327 | 186857 | 111904 | 46386974 |
| Throat tightness | 18.53 | 9.84 | 144 | 187040 | 20495 | 46478383 |
| Concussion | 18.49 | 9.84 | 66 | 187118 | 6937 | 46491941 |
| Agitation | 18.48 | 9.84 | 138 | 187046 | 55277 | 46443601 |
| Back pain | 18.25 | 9.84 | 1023 | 186161 | 209016 | 46289862 |
| Neuroleptic malignant syndrome | 18.20 | 9.84 | 11 | 187173 | 11111 | 46487767 |
| Eye infection bacterial | 18.06 | 9.84 | 9 | 187175 | 108 | 46498770 |
| Distal intestinal obstruction syndrome | 18.03 | 9.84 | 14 | 187170 | 383 | 46498495 |
| Proteinuria | 17.96 | 9.84 | 24 | 187160 | 16529 | 46482349 |
| Infusion site swelling | 17.96 | 9.84 | 57 | 187127 | 5642 | 46493236 |
| Toxic skin eruption | 17.94 | 9.84 | 14 | 187170 | 12373 | 46486505 |
| Lymphopenia | 17.82 | 9.84 | 21 | 187163 | 15272 | 46483606 |
| Thyroid atrophy | 17.78 | 9.84 | 6 | 187178 | 23 | 46498855 |
| Pregnancy | 17.69 | 9.84 | 53 | 187131 | 27084 | 46471794 |
| Total lung capacity decreased | 17.62 | 9.84 | 22 | 187162 | 1087 | 46497791 |
| Conjunctivitis allergic | 17.60 | 9.84 | 18 | 187166 | 713 | 46498165 |
| Encephalopathy | 17.60 | 9.84 | 72 | 187112 | 33517 | 46465361 |
| Expiratory reserve volume decreased | 17.55 | 9.84 | 7 | 187177 | 47 | 46498831 |
| Bronchial haemorrhage | 17.51 | 9.84 | 13 | 187171 | 332 | 46498546 |
| Vomiting | 17.41 | 9.84 | 1571 | 185613 | 451223 | 46047655 |
| Nasal discharge discolouration | 17.31 | 9.84 | 25 | 187159 | 1423 | 46497455 |
| Extrapyramidal disorder | 17.27 | 9.84 | 12 | 187172 | 11256 | 46487622 |
| Haemolytic anaemia | 17.16 | 9.84 | 9 | 187175 | 9833 | 46489045 |
| Immune-mediated pancreatitis | 16.95 | 9.84 | 7 | 187177 | 52 | 46498826 |
| Subarachnoid haemorrhage | 16.94 | 9.84 | 12 | 187172 | 11141 | 46487737 |
| Drug-induced liver injury | 16.93 | 9.84 | 49 | 187135 | 25319 | 46473559 |
| Metastases to lung | 16.92 | 9.84 | 11 | 187173 | 10685 | 46488193 |
| Nasal obstruction | 16.84 | 9.84 | 17 | 187167 | 663 | 46498215 |
| Myelodysplastic syndrome | 16.82 | 9.84 | 23 | 187161 | 15688 | 46483190 |
| Aplastic anaemia | 16.80 | 9.84 | 4 | 187180 | 7149 | 46491729 |
| Nasal oedema | 16.66 | 9.84 | 19 | 187165 | 853 | 46498025 |
| Expired product administered | 16.60 | 9.84 | 55 | 187129 | 5567 | 46493311 |
| Cardiogenic shock | 16.54 | 9.84 | 25 | 187159 | 16359 | 46482519 |
| Tubulointerstitial nephritis | 16.50 | 9.84 | 21 | 187163 | 14767 | 46484111 |
| Mydriasis | 16.50 | 9.84 | 11 | 187173 | 10542 | 46488336 |
| Anuria | 16.45 | 9.84 | 13 | 187171 | 11418 | 46487460 |
| Ascites | 16.43 | 9.84 | 83 | 187101 | 36501 | 46462377 |
| Haematuria | 16.42 | 9.84 | 54 | 187130 | 26804 | 46472074 |
| Bronchial neoplasm | 16.39 | 9.84 | 11 | 187173 | 238 | 46498640 |
| Hereditary angioedema | 16.32 | 9.84 | 54 | 187130 | 5462 | 46493416 |
| Sensitivity to weather change | 16.32 | 9.84 | 54 | 187130 | 5462 | 46493416 |
| Cholecystitis chronic | 16.13 | 9.84 | 84 | 187100 | 10415 | 46488463 |
| Premature labour | 16.08 | 9.84 | 13 | 187171 | 11286 | 46487592 |
| Hypokalaemia | 16.07 | 9.84 | 252 | 186932 | 87772 | 46411106 |
| Drug level increased | 16.00 | 9.84 | 31 | 187153 | 18410 | 46480468 |
| Parkinsonism | 15.85 | 9.84 | 6 | 187178 | 7942 | 46490936 |
| Decreased bronchial secretion | 15.80 | 9.84 | 7 | 187177 | 63 | 46498815 |
| Inappropriate antidiuretic hormone secretion | 15.76 | 9.84 | 20 | 187164 | 14082 | 46484796 |
| Lung diffusion test decreased | 15.68 | 9.84 | 16 | 187168 | 632 | 46498246 |
| Cushingoid | 15.65 | 9.84 | 58 | 187126 | 6208 | 46492670 |
| Rash | 15.64 | 9.84 | 1224 | 185960 | 355288 | 46143590 |
| Psychotic disorder | 15.61 | 9.84 | 43 | 187141 | 22578 | 46476300 |
| Sputum purulent | 15.47 | 9.84 | 18 | 187166 | 826 | 46498052 |
| Bronchial secretion retention | 15.46 | 9.84 | 19 | 187165 | 924 | 46497954 |
| Interstitial lung disease | 15.41 | 9.84 | 140 | 187044 | 53809 | 46445069 |
| Oliguria | 15.29 | 9.84 | 8 | 187176 | 8751 | 46490127 |
| Arteriosclerosis coronary artery | 15.23 | 9.84 | 69 | 187115 | 8087 | 46490791 |
| Haemoglobin decreased | 15.19 | 9.84 | 397 | 186787 | 128552 | 46370326 |
| Administration site erythema | 15.16 | 9.84 | 15 | 187169 | 571 | 46498307 |
| Myelosuppression | 15.06 | 9.84 | 6 | 187178 | 7697 | 46491181 |
| Lipohypertrophy | 15.05 | 9.84 | 17 | 187167 | 755 | 46498123 |
| Infective exacerbation of chronic obstructive airways disease | 15.03 | 9.84 | 21 | 187163 | 1159 | 46497719 |
| Total lung capacity increased | 15.02 | 9.84 | 17 | 187167 | 757 | 46498121 |
| Lung neoplasm malignant | 15.00 | 9.84 | 110 | 187074 | 15379 | 46483499 |
| Respiration abnormal | 14.97 | 9.84 | 46 | 187138 | 4475 | 46494403 |
| Generalised tonic-clonic seizure | 14.93 | 9.84 | 57 | 187127 | 27065 | 46471813 |
| Fracture | 14.89 | 9.84 | 27 | 187157 | 16444 | 46482434 |
| Acute respiratory distress syndrome | 14.88 | 9.84 | 42 | 187142 | 21880 | 46476998 |
| Ear discomfort | 14.78 | 9.84 | 60 | 187124 | 6701 | 46492177 |
| Diverticulum | 14.77 | 9.84 | 86 | 187098 | 11120 | 46487758 |
| Dystonia | 14.75 | 9.84 | 14 | 187170 | 11243 | 46487635 |
| Cystic fibrosis related diabetes | 14.71 | 9.84 | 6 | 187178 | 43 | 46498835 |
| Perineal fistula | 14.71 | 9.84 | 6 | 187178 | 43 | 46498835 |
| Polyneuropathy | 14.66 | 9.84 | 15 | 187169 | 11629 | 46487249 |
| Limb injury | 14.66 | 9.84 | 129 | 187055 | 19045 | 46479833 |
| Infusion site haemorrhage | 14.58 | 9.84 | 29 | 187155 | 2145 | 46496733 |
| Stillbirth | 14.54 | 9.84 | 4 | 187180 | 6487 | 46492391 |
| Eosinophilic bronchitis | 14.48 | 9.84 | 11 | 187173 | 291 | 46498587 |
| Infusion site pruritus | 14.43 | 9.84 | 36 | 187148 | 3102 | 46495776 |
| Multiple drug therapy | 14.36 | 9.84 | 18 | 187166 | 893 | 46497985 |
| Hypercapnia | 14.33 | 9.84 | 46 | 187138 | 4580 | 46494298 |
| Epilepsy | 14.32 | 9.84 | 48 | 187136 | 23690 | 46475188 |
| Neutropenic sepsis | 14.28 | 9.84 | 17 | 187167 | 12307 | 46486571 |
| Infusion site pain | 14.27 | 9.84 | 79 | 187105 | 10028 | 46488850 |
| Fluid overload | 14.13 | 9.84 | 169 | 187015 | 27016 | 46471862 |
| Functional residual capacity increased | 14.12 | 9.84 | 7 | 187177 | 83 | 46498795 |
| Cystic fibrosis lung | 14.09 | 9.84 | 8 | 187176 | 127 | 46498751 |
| Febrile bone marrow aplasia | 13.99 | 9.84 | 5 | 187179 | 6857 | 46492021 |
| Sarcoidosis | 13.95 | 9.84 | 49 | 187135 | 5110 | 46493768 |
| Oesophageal spasm | 13.90 | 9.84 | 27 | 187157 | 1962 | 46496916 |
| Heart sounds | 13.90 | 9.84 | 10 | 187174 | 243 | 46498635 |
| Chronic respiratory failure | 13.84 | 9.84 | 25 | 187159 | 1719 | 46497159 |
| Rash maculo-papular | 13.83 | 9.84 | 61 | 187123 | 27813 | 46471065 |
| Plasma cell myeloma | 13.79 | 9.84 | 113 | 187071 | 44365 | 46454513 |
| Product use issue | 13.78 | 9.84 | 282 | 186902 | 94362 | 46404516 |
| Administration site swelling | 13.76 | 9.84 | 20 | 187164 | 1145 | 46497733 |
| Growth failure | 13.74 | 9.84 | 11 | 187173 | 315 | 46498563 |
| Growth retardation | 13.69 | 9.84 | 18 | 187166 | 937 | 46497941 |
| Brain oedema | 13.63 | 9.84 | 18 | 187166 | 12460 | 46486418 |
| Fatigue | 13.62 | 9.84 | 2701 | 184483 | 605996 | 45892882 |
| Burning sensation | 13.60 | 9.84 | 252 | 186932 | 44159 | 46454719 |
| Stress | 13.59 | 9.84 | 286 | 186898 | 51265 | 46447613 |
| Bronchiolitis | 13.58 | 9.84 | 29 | 187155 | 2256 | 46496622 |
| Metastases to central nervous system | 13.52 | 9.84 | 15 | 187169 | 11206 | 46487672 |
| Bronchitis chronic | 13.43 | 9.84 | 42 | 187142 | 4125 | 46494753 |
| Mobility decreased | 13.36 | 9.84 | 167 | 187017 | 60427 | 46438451 |
| Femoral neck fracture | 13.28 | 9.84 | 8 | 187176 | 8095 | 46490783 |
| Forced expiratory flow decreased | 13.26 | 9.84 | 6 | 187178 | 57 | 46498821 |
| Oropharyngitis fungal | 13.17 | 9.84 | 6 | 187178 | 58 | 46498820 |
| Magnetic resonance imaging thoracic abnormal | 13.15 | 9.84 | 5 | 187179 | 29 | 46498849 |
| Peripheral sensory neuropathy | 13.14 | 9.84 | 5 | 187179 | 6598 | 46492280 |
| Premature delivery | 13.06 | 9.84 | 45 | 187139 | 22024 | 46476854 |
| Nasal dryness | 12.91 | 9.84 | 37 | 187147 | 3463 | 46495415 |
| Embolism venous | 12.86 | 9.84 | 30 | 187154 | 2477 | 46496401 |
| Ulcer | 12.81 | 9.84 | 32 | 187152 | 17360 | 46481518 |
| Torsade de pointes | 12.81 | 9.84 | 18 | 187166 | 12136 | 46486742 |
| Nephropathy toxic | 12.73 | 9.84 | 7 | 187177 | 7447 | 46491431 |
| Allergy to animal | 12.72 | 9.84 | 14 | 187170 | 604 | 46498274 |
| Hepatic enzyme increased | 12.72 | 9.84 | 241 | 186943 | 81546 | 46417332 |
| Ear pain | 12.67 | 9.84 | 140 | 187044 | 21952 | 46476926 |
| Restlessness | 12.58 | 9.84 | 56 | 187128 | 25468 | 46473410 |
| Acute hepatic failure | 12.55 | 9.84 | 25 | 187159 | 14696 | 46484182 |
| Fracture displacement | 12.48 | 9.84 | 20 | 187164 | 1248 | 46497630 |
| Body mass index increased | 12.44 | 9.84 | 18 | 187166 | 1026 | 46497852 |
| Central obesity | 12.35 | 9.84 | 16 | 187168 | 821 | 46498057 |
| Nasal pruritus | 12.24 | 9.84 | 10 | 187174 | 295 | 46498583 |
| Transferrin saturation decreased | 12.23 | 9.84 | 12 | 187172 | 452 | 46498426 |
| Cystic fibrosis respiratory infection suppression | 12.17 | 9.84 | 12 | 187172 | 455 | 46498423 |
| Epstein-Barr virus infection | 12.13 | 9.84 | 6 | 187178 | 6778 | 46492100 |
| Red blood cell sedimentation rate increased | 12.03 | 9.84 | 49 | 187135 | 22840 | 46476038 |
| Impaired healing | 12.01 | 9.84 | 92 | 187092 | 36651 | 46462227 |
| Functional residual capacity decreased | 11.97 | 9.84 | 6 | 187178 | 73 | 46498805 |
| Contusion | 11.92 | 9.84 | 446 | 186738 | 87041 | 46411837 |
| Peak expiratory flow rate abnormal | 11.91 | 9.84 | 7 | 187177 | 119 | 46498759 |
| Hypoxia | 11.90 | 9.84 | 282 | 186902 | 51556 | 46447322 |
| Symptom recurrence | 11.88 | 9.84 | 11 | 187173 | 385 | 46498493 |
| Hyperhidrosis | 11.86 | 9.84 | 454 | 186730 | 88854 | 46410024 |
| Tobacco abuse | 11.83 | 9.84 | 14 | 187170 | 654 | 46498224 |
| Blood creatine phosphokinase increased | 11.83 | 9.84 | 64 | 187120 | 27660 | 46471218 |
| Secondary adrenocortical insufficiency | 11.79 | 9.84 | 16 | 187168 | 859 | 46498019 |
| Gammopathy | 11.75 | 9.84 | 7 | 187177 | 122 | 46498756 |
| Muscle spasms | 11.75 | 9.84 | 605 | 186579 | 122508 | 46376370 |
| Nasal mucosal discolouration | 11.72 | 9.84 | 4 | 187180 | 16 | 46498862 |
| Hyperthermia | 11.68 | 9.84 | 9 | 187175 | 8005 | 46490873 |
| Infusion site nodule | 11.65 | 9.84 | 17 | 187167 | 977 | 46497901 |
| Restrictive pulmonary disease | 11.61 | 9.84 | 19 | 187165 | 1207 | 46497671 |
| Small airways disease | 11.53 | 9.84 | 4 | 187180 | 17 | 46498861 |
| Ear canal erythema | 11.50 | 9.84 | 3 | 187181 | 3 | 46498875 |
| Vocal cord atrophy | 11.50 | 9.84 | 3 | 187181 | 3 | 46498875 |
| Cardiovascular deconditioning | 11.50 | 9.84 | 3 | 187181 | 3 | 46498875 |
| Fungal endocarditis | 11.47 | 9.84 | 9 | 187175 | 250 | 46498628 |
| Sedation | 11.45 | 9.84 | 50 | 187134 | 22860 | 46476018 |
| Hiatus hernia | 11.44 | 9.84 | 118 | 187066 | 18184 | 46480694 |
| Gluten sensitivity | 11.44 | 9.84 | 12 | 187172 | 490 | 46498388 |
| Physiotherapy | 11.38 | 9.84 | 5 | 187179 | 44 | 46498834 |
| Trifascicular block | 11.37 | 9.84 | 7 | 187177 | 130 | 46498748 |
| Laryngitis viral | 11.35 | 9.84 | 4 | 187180 | 18 | 46498860 |
| Vocal cord disorder | 11.24 | 9.84 | 19 | 187165 | 1239 | 46497639 |
| Blood test abnormal | 11.24 | 9.84 | 71 | 187113 | 9449 | 46489429 |
| Dermatitis atopic | 11.23 | 9.84 | 21 | 187163 | 1483 | 46497395 |
| Bronchial irritation | 11.17 | 9.84 | 4 | 187180 | 19 | 46498859 |
| Accidental overdose | 11.16 | 9.84 | 42 | 187142 | 20024 | 46478854 |
| Exercise tolerance decreased | 11.13 | 9.84 | 42 | 187142 | 4535 | 46494343 |
| Retching | 11.12 | 9.84 | 90 | 187094 | 12967 | 46485911 |
| Hypercalcaemia | 11.10 | 9.84 | 45 | 187139 | 21001 | 46477877 |
| Electrocardiogram QRS complex prolonged | 11.06 | 9.84 | 4 | 187180 | 5445 | 46493433 |
| Shock haemorrhagic | 10.98 | 9.84 | 11 | 187173 | 8613 | 46490265 |
| Insomnia | 10.96 | 9.84 | 785 | 186399 | 164139 | 46334739 |
| Foot deformity | 10.89 | 9.84 | 29 | 187155 | 15396 | 46483482 |
| Hypoglycaemia | 10.81 | 9.84 | 153 | 187031 | 54196 | 46444682 |
| Hypocalcaemia | 10.80 | 9.84 | 63 | 187121 | 26722 | 46472156 |
| Injection site inflammation | 10.68 | 9.84 | 32 | 187152 | 3070 | 46495808 |
| Eczema | 10.68 | 9.84 | 127 | 187057 | 20273 | 46478605 |
| Infusion site urticaria | 10.61 | 9.84 | 14 | 187170 | 731 | 46498147 |
| Sinus operation | 10.48 | 9.84 | 20 | 187164 | 1435 | 46497443 |
| Ventricular tachycardia | 10.45 | 9.84 | 34 | 187150 | 16933 | 46481945 |
| Hyperreflexia | 10.42 | 9.84 | 4 | 187180 | 5250 | 46493628 |
| Ligament sprain | 10.35 | 9.84 | 75 | 187109 | 10444 | 46488434 |
| Exposure to allergen | 10.33 | 9.84 | 7 | 187177 | 154 | 46498724 |
| Stoma obstruction | 10.30 | 9.84 | 3 | 187181 | 6 | 46498872 |
| Pituitary-dependent Cushing's syndrome | 10.30 | 9.84 | 3 | 187181 | 6 | 46498872 |
| Therapy partial responder | 10.27 | 9.84 | 3 | 187181 | 4679 | 46494199 |
| Enterocolitis | 10.23 | 9.84 | 6 | 187178 | 6162 | 46492716 |
| Choking | 10.22 | 9.84 | 63 | 187121 | 8313 | 46490565 |
| Hyperplastic cholecystopathy | 10.21 | 9.84 | 6 | 187178 | 102 | 46498776 |
| Vital capacity decreased | 10.20 | 9.84 | 12 | 187172 | 557 | 46498321 |
| Respiratory tract infection viral | 10.19 | 9.84 | 23 | 187161 | 1858 | 46497020 |
| Osteonecrosis | 10.14 | 9.84 | 61 | 187123 | 25683 | 46473195 |
| Injection site reaction | 10.13 | 9.84 | 133 | 187051 | 47716 | 46451162 |
| Disorientation | 10.03 | 9.84 | 97 | 187087 | 36821 | 46462057 |
| Electrocardiogram QT prolonged | 10.03 | 9.84 | 145 | 187039 | 51180 | 46447698 |
| Gastroenteritis viral | 10.02 | 9.84 | 114 | 187070 | 18005 | 46480873 |
| Investigation | 10.01 | 9.84 | 21 | 187163 | 1613 | 46497265 |
| Pyelonephritis | 10.01 | 9.84 | 30 | 187154 | 15327 | 46483551 |
| Biliary dyskinesia | 9.92 | 9.84 | 29 | 187155 | 2744 | 46496134 |
| Abdominal discomfort | 9.91 | 9.84 | 500 | 186684 | 150665 | 46348213 |
| Pharyngitis streptococcal | 9.90 | 9.84 | 63 | 187121 | 8405 | 46490473 |
| Hilar lymphadenopathy | 9.85 | 9.84 | 16 | 187168 | 1010 | 46497868 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Asthma | 1642.78 | 10.16 | 1141 | 90036 | 35033 | 29826268 |
| Wheezing | 537.30 | 10.16 | 562 | 90615 | 30376 | 29830925 |
| Chronic obstructive pulmonary disease | 445.45 | 10.16 | 622 | 90555 | 45504 | 29815797 |
| Dyspnoea | 367.74 | 10.16 | 1986 | 89191 | 331309 | 29529992 |
| Obstructive airways disorder | 326.77 | 10.16 | 249 | 90928 | 8810 | 29852491 |
| Cough | 313.38 | 10.16 | 966 | 90211 | 124676 | 29736625 |
| Toxicity to various agents | 278.74 | 10.16 | 96 | 91081 | 177087 | 29684214 |
| Infective pulmonary exacerbation of cystic fibrosis | 264.71 | 10.16 | 215 | 90962 | 8357 | 29852944 |
| Productive cough | 246.91 | 10.16 | 375 | 90802 | 29578 | 29831723 |
| Sputum discoloured | 226.75 | 10.16 | 177 | 91000 | 6491 | 29854810 |
| Eosinophilic granulomatosis with polyangiitis | 222.65 | 10.16 | 99 | 91078 | 1216 | 29860085 |
| Forced expiratory volume decreased | 196.97 | 10.16 | 123 | 91054 | 3127 | 29858174 |
| Completed suicide | 190.58 | 10.16 | 36 | 91141 | 99456 | 29761845 |
| Sinusitis | 181.38 | 10.16 | 347 | 90830 | 32998 | 29828303 |
| Blood count abnormal | 178.10 | 10.16 | 198 | 90979 | 11454 | 29849847 |
| Nasal congestion | 163.77 | 10.16 | 240 | 90937 | 18326 | 29842975 |
| Adrenal suppression | 155.16 | 10.16 | 62 | 91115 | 571 | 29860730 |
| Pneumonia | 151.44 | 10.16 | 1617 | 89560 | 332689 | 29528612 |
| Product quality issue | 136.56 | 10.16 | 222 | 90955 | 18552 | 29842749 |
| Bronchitis | 121.60 | 10.16 | 326 | 90851 | 38799 | 29822502 |
| Pulmonary function test decreased | 120.66 | 10.16 | 102 | 91075 | 4193 | 29857108 |
| Chest discomfort | 113.30 | 10.16 | 350 | 90827 | 45130 | 29816171 |
| Bronchiectasis | 107.59 | 10.16 | 104 | 91073 | 5100 | 29856201 |
| Drug abuse | 100.23 | 10.16 | 63 | 91114 | 82009 | 29779292 |
| Respiratory tract congestion | 91.86 | 10.16 | 98 | 91079 | 5408 | 29855893 |
| Thrombocytopenia | 89.60 | 10.16 | 176 | 91001 | 136868 | 29724433 |
| Therapeutic product effect incomplete | 88.58 | 10.16 | 265 | 90912 | 33569 | 29827732 |
| Nasal obstruction | 86.39 | 10.16 | 42 | 91135 | 640 | 29860661 |
| Nasopharyngitis | 82.13 | 10.16 | 376 | 90801 | 58473 | 29802828 |
| Cystic fibrosis | 80.87 | 10.16 | 62 | 91115 | 2212 | 29859089 |
| Nasal polyps | 78.08 | 10.16 | 50 | 91127 | 1329 | 29859972 |
| Dyspnoea exertional | 76.76 | 10.16 | 260 | 90917 | 35170 | 29826131 |
| Asthma-chronic obstructive pulmonary disease overlap syndrome | 75.25 | 10.16 | 38 | 91139 | 631 | 29860670 |
| Sleep disorder due to a general medical condition | 71.66 | 10.16 | 49 | 91128 | 1458 | 29859843 |
| Neutropenia | 70.99 | 10.16 | 181 | 90996 | 128359 | 29732942 |
| Blood immunoglobulin E increased | 67.81 | 10.16 | 50 | 91127 | 1680 | 29859621 |
| Throat irritation | 66.15 | 10.16 | 104 | 91073 | 8444 | 29852857 |
| Acute kidney injury | 65.00 | 10.16 | 528 | 90649 | 273314 | 29587987 |
| Multiple organ dysfunction syndrome | 64.35 | 10.16 | 59 | 91118 | 63428 | 29797873 |
| Upper respiratory tract infection | 64.31 | 10.16 | 207 | 90970 | 27269 | 29834032 |
| Breath sounds abnormal | 63.88 | 10.16 | 77 | 91100 | 4858 | 29856443 |
| Renal impairment | 62.29 | 10.16 | 100 | 91077 | 84084 | 29777217 |
| Respiratory disorder | 61.78 | 10.16 | 153 | 91024 | 17341 | 29843960 |
| Middle insomnia | 60.37 | 10.16 | 81 | 91096 | 5692 | 29855609 |
| Influenza | 60.32 | 10.16 | 277 | 90900 | 43121 | 29818180 |
| Bronchial hyperreactivity | 59.46 | 10.16 | 40 | 91137 | 1158 | 29860143 |
| Intentional overdose | 57.68 | 10.16 | 27 | 91150 | 41454 | 29819847 |
| Sinus pain | 57.22 | 10.16 | 32 | 91145 | 659 | 29860642 |
| Sputum increased | 56.10 | 10.16 | 46 | 91131 | 1811 | 29859490 |
| Renal failure | 53.29 | 10.16 | 207 | 90970 | 128759 | 29732542 |
| Nasal disorder | 53.15 | 10.16 | 37 | 91140 | 1134 | 29860167 |
| Lower respiratory tract infection | 52.63 | 10.16 | 190 | 90987 | 26524 | 29834777 |
| Cortisol decreased | 51.27 | 10.16 | 33 | 91144 | 885 | 29860416 |
| Product dose omission issue | 51.26 | 10.16 | 464 | 90713 | 91167 | 29770134 |
| Off label use | 49.79 | 10.16 | 502 | 90675 | 248788 | 29612513 |
| Rhinorrhoea | 49.14 | 10.16 | 157 | 91020 | 20597 | 29840704 |
| Pancytopenia | 49.08 | 10.16 | 117 | 91060 | 84935 | 29776366 |
| Bone marrow failure | 48.71 | 10.16 | 15 | 91162 | 29770 | 29831531 |
| Respiratory rate increased | 48.71 | 10.16 | 93 | 91084 | 8822 | 29852479 |
| Anaemia | 47.92 | 10.16 | 404 | 90773 | 207588 | 29653713 |
| Inhalation therapy | 47.52 | 10.16 | 13 | 91164 | 28 | 29861273 |
| Status asthmaticus | 47.23 | 10.16 | 22 | 91155 | 303 | 29860998 |
| Febrile neutropenia | 46.84 | 10.16 | 167 | 91010 | 106526 | 29754775 |
| Central obesity | 46.64 | 10.16 | 26 | 91151 | 532 | 29860769 |
| Dust allergy | 44.90 | 10.16 | 23 | 91154 | 394 | 29860907 |
| Hepatic function abnormal | 44.90 | 10.16 | 37 | 91140 | 41908 | 29819393 |
| Oxygen saturation decreased | 44.77 | 10.16 | 255 | 90922 | 43185 | 29818116 |
| Rhabdomyolysis | 44.73 | 10.16 | 78 | 91099 | 63502 | 29797799 |
| Malignant neoplasm progression | 44.50 | 10.16 | 96 | 91081 | 72191 | 29789110 |
| Bronchospasm | 43.69 | 10.16 | 97 | 91080 | 10241 | 29851060 |
| Blood creatinine increased | 43.53 | 10.16 | 138 | 91039 | 91237 | 29770064 |
| Sinus disorder | 43.08 | 10.16 | 72 | 91105 | 6153 | 29855148 |
| Emphysema | 42.91 | 10.16 | 91 | 91086 | 9311 | 29851990 |
| Cushingoid | 42.79 | 10.16 | 45 | 91132 | 2442 | 29858859 |
| Hypothalamic pituitary adrenal axis suppression | 42.31 | 10.16 | 18 | 91159 | 197 | 29861104 |
| Sensitivity to weather change | 41.81 | 10.16 | 35 | 91142 | 1419 | 29859882 |
| Seasonal allergy | 41.25 | 10.16 | 61 | 91116 | 4692 | 29856609 |
| Painful respiration | 41.13 | 10.16 | 33 | 91144 | 1259 | 29860042 |
| Pulmonary function test abnormal | 40.96 | 10.16 | 34 | 91143 | 1362 | 29859939 |
| Dysphonia | 40.62 | 10.16 | 139 | 91038 | 18893 | 29842408 |
| Pulmonary mass | 40.48 | 10.16 | 97 | 91080 | 10765 | 29850536 |
| Cytomegalovirus infection | 40.41 | 10.16 | 11 | 91166 | 23663 | 29837638 |
| Heart rate increased | 40.36 | 10.16 | 228 | 90949 | 38493 | 29822808 |
| Leukopenia | 40.32 | 10.16 | 68 | 91109 | 56091 | 29805210 |
| Osteopenia | 39.41 | 10.16 | 59 | 91118 | 4589 | 29856712 |
| Vocal cord dysfunction | 38.97 | 10.16 | 16 | 91161 | 159 | 29861142 |
| Hypoventilation | 38.85 | 10.16 | 47 | 91130 | 2976 | 29858325 |
| Adrenal insufficiency | 38.53 | 10.16 | 93 | 91084 | 10370 | 29850931 |
| Respiratory tract infection | 38.27 | 10.16 | 119 | 91058 | 15387 | 29845914 |
| Neuroleptic malignant syndrome | 38.20 | 10.16 | 3 | 91174 | 16292 | 29845009 |
| Mycobacterium avium complex infection | 37.90 | 10.16 | 44 | 91133 | 2667 | 29858634 |
| Platelet count decreased | 37.90 | 10.16 | 180 | 90997 | 105949 | 29755352 |
| Interstitial lung disease | 37.84 | 10.16 | 79 | 91098 | 60118 | 29801183 |
| Chorioretinopathy | 37.77 | 10.16 | 33 | 91144 | 1419 | 29859882 |
| Rhinitis | 37.42 | 10.16 | 57 | 91120 | 4502 | 29856799 |
| Restrictive pulmonary disease | 37.36 | 10.16 | 29 | 91148 | 1054 | 29860247 |
| Drug resistance | 37.01 | 10.16 | 8 | 91169 | 20125 | 29841176 |
| Sleep apnoea syndrome | 36.75 | 10.16 | 124 | 91053 | 16733 | 29844568 |
| Anosmia | 36.13 | 10.16 | 38 | 91139 | 2062 | 29859239 |
| Overdose | 35.69 | 10.16 | 134 | 91043 | 84203 | 29777098 |
| Secondary adrenocortical insufficiency | 34.58 | 10.16 | 27 | 91150 | 990 | 29860311 |
| Rhinalgia | 34.47 | 10.16 | 19 | 91158 | 380 | 29860921 |
| Increased viscosity of bronchial secretion | 33.86 | 10.16 | 16 | 91161 | 228 | 29861073 |
| Gastrooesophageal reflux disease | 33.66 | 10.16 | 190 | 90987 | 32065 | 29829236 |
| Sinus congestion | 33.19 | 10.16 | 55 | 91122 | 4667 | 29856634 |
| Growth retardation | 33.12 | 10.16 | 32 | 91145 | 1568 | 29859733 |
| Sneezing | 32.59 | 10.16 | 52 | 91125 | 4275 | 29857026 |
| Cerebral infarction | 32.51 | 10.16 | 20 | 91157 | 26353 | 29834948 |
| Cushing's syndrome | 31.87 | 10.16 | 19 | 91158 | 443 | 29860858 |
| Hospitalisation | 31.51 | 10.16 | 237 | 90940 | 44082 | 29817219 |
| Eosinophil count increased | 31.44 | 10.16 | 70 | 91107 | 7403 | 29853898 |
| Nasal discharge discolouration | 31.24 | 10.16 | 15 | 91162 | 222 | 29861079 |
| Product complaint | 31.02 | 10.16 | 60 | 91117 | 5746 | 29855555 |
| Death | 30.94 | 10.16 | 840 | 90337 | 356443 | 29504858 |
| Malaise | 30.94 | 10.16 | 695 | 90482 | 166267 | 29695034 |
| Rhinitis allergic | 30.86 | 10.16 | 41 | 91136 | 2853 | 29858448 |
| Foetal malformation | 30.83 | 10.16 | 13 | 91164 | 139 | 29861162 |
| Peripheral swelling | 30.50 | 10.16 | 302 | 90875 | 60772 | 29800529 |
| Hepatocellular injury | 30.45 | 10.16 | 20 | 91157 | 25451 | 29835850 |
| Chronic sinusitis | 30.07 | 10.16 | 30 | 91147 | 1529 | 29859772 |
| Blood urea increased | 29.66 | 10.16 | 31 | 91146 | 31350 | 29829951 |
| Bronchial wall thickening | 29.66 | 10.16 | 18 | 91159 | 434 | 29860867 |
| Body temperature decreased | 29.51 | 10.16 | 80 | 91097 | 9575 | 29851726 |
| Neutrophil count decreased | 29.02 | 10.16 | 53 | 91124 | 42401 | 29818900 |
| Mucosal inflammation | 28.96 | 10.16 | 30 | 91147 | 30464 | 29830837 |
| Septic shock | 28.94 | 10.16 | 98 | 91079 | 63509 | 29797792 |
| Ear infection | 28.73 | 10.16 | 67 | 91110 | 7307 | 29853994 |
| Blood pressure increased | 28.66 | 10.16 | 340 | 90837 | 71588 | 29789713 |
| Depressed level of consciousness | 28.63 | 10.16 | 45 | 91132 | 38177 | 29823124 |
| Mite allergy | 28.47 | 10.16 | 14 | 91163 | 219 | 29861082 |
| Delirium | 28.43 | 10.16 | 50 | 91127 | 40581 | 29820720 |
| Upper-airway cough syndrome | 28.30 | 10.16 | 38 | 91139 | 2672 | 29858629 |
| Sepsis | 28.24 | 10.16 | 297 | 90880 | 146098 | 29715203 |
| Peritonitis | 28.07 | 10.16 | 15 | 91162 | 21360 | 29839941 |
| Cholestasis | 27.97 | 10.16 | 21 | 91156 | 24929 | 29836372 |
| General physical health deterioration | 27.79 | 10.16 | 184 | 90993 | 99760 | 29761541 |
| Respiratory tract irritation | 27.68 | 10.16 | 12 | 91165 | 138 | 29861163 |
| Alanine aminotransferase increased | 27.67 | 10.16 | 124 | 91053 | 74152 | 29787149 |
| Cardio-respiratory arrest | 27.66 | 10.16 | 86 | 91091 | 57220 | 29804081 |
| C-reactive protein increased | 27.36 | 10.16 | 57 | 91120 | 43416 | 29817885 |
| Lung diffusion test decreased | 27.10 | 10.16 | 19 | 91158 | 589 | 29860712 |
| Asthmatic crisis | 26.34 | 10.16 | 17 | 91160 | 458 | 29860843 |
| Weight decreased | 26.33 | 10.16 | 623 | 90554 | 150298 | 29711003 |
| Lower respiratory tract congestion | 26.30 | 10.16 | 23 | 91154 | 990 | 29860311 |
| Serotonin syndrome | 25.88 | 10.16 | 11 | 91166 | 17880 | 29843421 |
| Cardiac arrest | 25.78 | 10.16 | 171 | 91006 | 92679 | 29768622 |
| Coma | 25.48 | 10.16 | 53 | 91124 | 40396 | 29820905 |
| Granulomatous rosacea | 25.40 | 10.16 | 12 | 91165 | 171 | 29861130 |
| Forced vital capacity decreased | 25.18 | 10.16 | 20 | 91157 | 752 | 29860549 |
| Trisomy 18 | 25.00 | 10.16 | 13 | 91164 | 230 | 29861071 |
| Hepatic failure | 24.63 | 10.16 | 41 | 91136 | 34002 | 29827299 |
| Walking aid user | 24.57 | 10.16 | 26 | 91151 | 1421 | 29859880 |
| Toxic epidermal necrolysis | 24.44 | 10.16 | 12 | 91165 | 17928 | 29843373 |
| Disseminated intravascular coagulation | 24.42 | 10.16 | 19 | 91158 | 22152 | 29839149 |
| Fatigue | 24.39 | 10.16 | 1201 | 89976 | 319472 | 29541829 |
| Aspartate aminotransferase increased | 24.15 | 10.16 | 105 | 91072 | 63317 | 29797984 |
| Drug reaction with eosinophilia and systemic symptoms | 23.85 | 10.16 | 31 | 91146 | 28457 | 29832844 |
| Weight increased | 23.51 | 10.16 | 339 | 90838 | 74574 | 29786727 |
| Gamma-glutamyltransferase increased | 23.49 | 10.16 | 33 | 91144 | 29317 | 29831984 |
| Hypotension | 23.08 | 10.16 | 451 | 90726 | 200114 | 29661187 |
| Blood pressure systolic increased | 22.90 | 10.16 | 99 | 91078 | 15011 | 29846290 |
| Eosinophil count | 22.69 | 10.16 | 10 | 91167 | 120 | 29861181 |
| Agranulocytosis | 22.69 | 10.16 | 20 | 91157 | 21922 | 29839379 |
| Foetal exposure during pregnancy | 22.65 | 10.16 | 49 | 91128 | 36822 | 29824479 |
| Smoke sensitivity | 22.54 | 10.16 | 11 | 91166 | 169 | 29861132 |
| Chest injury | 22.26 | 10.16 | 24 | 91153 | 1340 | 29859961 |
| Treatment failure | 22.22 | 10.16 | 45 | 91132 | 34634 | 29826667 |
| Hepatotoxicity | 22.03 | 10.16 | 14 | 91163 | 18131 | 29843170 |
| Poisoning | 22.02 | 10.16 | 4 | 91173 | 11378 | 29849923 |
| Peritonitis bacterial | 22.01 | 10.16 | 4 | 91173 | 11374 | 29849927 |
| Suffocation feeling | 21.46 | 10.16 | 16 | 91161 | 547 | 29860754 |
| Bronchopulmonary aspergillosis allergic | 21.44 | 10.16 | 13 | 91164 | 313 | 29860988 |
| Product use in unapproved indication | 21.33 | 10.16 | 134 | 91043 | 73559 | 29787742 |
| Shock | 21.13 | 10.16 | 23 | 91154 | 22836 | 29838465 |
| Transposition of the great vessels | 21.06 | 10.16 | 15 | 91162 | 477 | 29860824 |
| Snoring | 20.76 | 10.16 | 34 | 91143 | 2857 | 29858444 |
| Bronchial obstruction | 20.71 | 10.16 | 24 | 91153 | 1452 | 29859849 |
| Reversible airways obstruction | 20.63 | 10.16 | 12 | 91165 | 267 | 29861034 |
| Drug intolerance | 20.45 | 10.16 | 70 | 91107 | 45221 | 29816080 |
| Ascites | 20.24 | 10.16 | 50 | 91127 | 35871 | 29825430 |
| Conjunctivitis allergic | 19.96 | 10.16 | 15 | 91162 | 519 | 29860782 |
| Blood lactate dehydrogenase increased | 19.87 | 10.16 | 20 | 91157 | 20581 | 29840720 |
| Hot flush | 19.86 | 10.16 | 93 | 91084 | 14587 | 29846714 |
| Mycotic allergy | 19.75 | 10.16 | 10 | 91167 | 167 | 29861134 |
| Nasal inflammation | 19.60 | 10.16 | 11 | 91166 | 228 | 29861073 |
| Altered state of consciousness | 19.60 | 10.16 | 19 | 91158 | 19900 | 29841401 |
| Lung hyperinflation | 19.50 | 10.16 | 18 | 91159 | 832 | 29860469 |
| Oropharyngeal pain | 19.47 | 10.16 | 151 | 91026 | 28345 | 29832956 |
| Loss of personal independence in daily activities | 19.35 | 10.16 | 122 | 91055 | 21413 | 29839888 |
| Hyperbilirubinaemia | 19.33 | 10.16 | 14 | 91163 | 16928 | 29844373 |
| Hypertrophic osteoarthropathy | 19.27 | 10.16 | 8 | 91169 | 82 | 29861219 |
| Acute hepatic failure | 19.26 | 10.16 | 6 | 91171 | 11821 | 29849480 |
| Haemoptysis | 19.23 | 10.16 | 161 | 91016 | 30917 | 29830384 |
| Blood bilirubin increased | 19.11 | 10.16 | 53 | 91124 | 36583 | 29824718 |
| Haemoglobin decreased | 19.05 | 10.16 | 239 | 90938 | 113859 | 29747442 |
| Respiratory symptom | 18.97 | 10.16 | 17 | 91160 | 756 | 29860545 |
| Carcinoid tumour of the gastrointestinal tract | 18.94 | 10.16 | 7 | 91170 | 51 | 29861250 |
| Blood immunoglobulin E decreased | 18.59 | 10.16 | 7 | 91170 | 54 | 29861247 |
| Tumour lysis syndrome | 18.51 | 10.16 | 8 | 91169 | 12877 | 29848424 |
| Hypersensitivity | 18.37 | 10.16 | 248 | 90929 | 53780 | 29807521 |
| Headache | 18.32 | 10.16 | 703 | 90474 | 181603 | 29679698 |
| Peak expiratory flow rate decreased | 18.17 | 10.16 | 9 | 91168 | 143 | 29861158 |
| Confusional state | 18.09 | 10.16 | 295 | 90882 | 134539 | 29726762 |
| Nephropathy toxic | 18.05 | 10.16 | 5 | 91172 | 10634 | 29850667 |
| Immune reconstitution inflammatory syndrome | 18.04 | 10.16 | 3 | 91174 | 9098 | 29852203 |
| Rales | 18.04 | 10.16 | 52 | 91125 | 6448 | 29854853 |
| Skin striae | 17.99 | 10.16 | 13 | 91164 | 423 | 29860878 |
| Drug-induced liver injury | 17.96 | 10.16 | 23 | 91154 | 21251 | 29840050 |
| Multiple allergies | 17.88 | 10.16 | 27 | 91150 | 2116 | 29859185 |
| Myocardial infarction | 17.81 | 10.16 | 272 | 90905 | 125353 | 29735948 |
| Migraine | 17.74 | 10.16 | 82 | 91095 | 12792 | 29848509 |
| Rhonchi | 17.68 | 10.16 | 24 | 91153 | 1705 | 29859596 |
| Cerebral haemorrhage | 17.59 | 10.16 | 47 | 91130 | 32840 | 29828461 |
| Throat tightness | 17.56 | 10.16 | 55 | 91122 | 7137 | 29854164 |
| Sputum purulent | 17.52 | 10.16 | 13 | 91164 | 441 | 29860860 |
| Choking | 17.19 | 10.16 | 43 | 91134 | 4903 | 29856398 |
| Stress | 17.18 | 10.16 | 113 | 91064 | 20122 | 29841179 |
| Jaundice | 16.94 | 10.16 | 47 | 91130 | 32439 | 29828862 |
| Cystic fibrosis respiratory infection suppression | 16.92 | 10.16 | 12 | 91165 | 379 | 29860922 |
| Tracheal disorder | 16.63 | 10.16 | 8 | 91169 | 119 | 29861182 |
| Acute respiratory failure | 16.58 | 10.16 | 135 | 91042 | 25715 | 29835586 |
| Lipohypertrophy | 16.45 | 10.16 | 11 | 91166 | 315 | 29860986 |
| Forced expiratory flow decreased | 16.39 | 10.16 | 8 | 91169 | 123 | 29861178 |
| Hyposmia | 16.33 | 10.16 | 9 | 91168 | 180 | 29861121 |
| Acute respiratory distress syndrome | 16.31 | 10.16 | 29 | 91148 | 23443 | 29837858 |
| Liver disorder | 16.26 | 10.16 | 42 | 91135 | 29680 | 29831621 |
| Blood test abnormal | 16.11 | 10.16 | 45 | 91132 | 5480 | 29855821 |
| Limb injury | 16.07 | 10.16 | 62 | 91115 | 8929 | 29852372 |
| Acute myocardial infarction | 15.97 | 10.16 | 95 | 91082 | 52844 | 29808457 |
| Haemophagocytic lymphohistiocytosis | 15.88 | 10.16 | 5 | 91172 | 9786 | 29851515 |
| Nasal discomfort | 15.84 | 10.16 | 19 | 91158 | 1192 | 29860109 |
| Nasal oedema | 15.83 | 10.16 | 11 | 91166 | 336 | 29860965 |
| Contusion | 15.76 | 10.16 | 155 | 91022 | 31125 | 29830176 |
| Bone deformity | 15.75 | 10.16 | 6 | 91171 | 48 | 29861253 |
| Drug interaction | 15.73 | 10.16 | 475 | 90702 | 199093 | 29662208 |
| Haemodialysis | 15.71 | 10.16 | 7 | 91170 | 11066 | 29850235 |
| Hyperkalaemia | 15.70 | 10.16 | 127 | 91050 | 65883 | 29795418 |
| Anxiety | 15.65 | 10.16 | 371 | 90806 | 89500 | 29771801 |
| Eye pruritus | 15.65 | 10.16 | 36 | 91141 | 3891 | 29857410 |
| Oral candidiasis | 15.62 | 10.16 | 71 | 91106 | 11000 | 29850301 |
| Vision blurred | 15.49 | 10.16 | 195 | 90982 | 41621 | 29819680 |
| Coma uraemic | 15.33 | 10.16 | 6 | 91171 | 52 | 29861249 |
| Alveolar bone resorption | 15.27 | 10.16 | 5 | 91172 | 24 | 29861277 |
| Hypoacusis | 15.22 | 10.16 | 84 | 91093 | 14055 | 29847246 |
| Eosinophilic oesophagitis | 15.21 | 10.16 | 9 | 91168 | 207 | 29861094 |
| Rheumatoid arthritis | 15.20 | 10.16 | 69 | 91108 | 41128 | 29820173 |
| Hypokalaemia | 15.18 | 10.16 | 90 | 91087 | 50102 | 29811199 |
| Lung consolidation | 15.10 | 10.16 | 41 | 91136 | 4911 | 29856390 |
| White blood cell count decreased | 15.09 | 10.16 | 173 | 91004 | 83774 | 29777527 |
| Gastroenteritis viral | 15.07 | 10.16 | 46 | 91131 | 5887 | 29855414 |
| Vomiting | 15.00 | 10.16 | 533 | 90644 | 219285 | 29642016 |
| Hyperthermia | 14.94 | 10.16 | 6 | 91171 | 10093 | 29851208 |
| Blood corticotrophin decreased | 14.93 | 10.16 | 8 | 91169 | 151 | 29861150 |
| Neurotoxicity | 14.90 | 10.16 | 11 | 91166 | 13171 | 29848130 |
| Hypersomnia | 14.81 | 10.16 | 71 | 91106 | 11245 | 29850056 |
| Extrapyramidal disorder | 14.80 | 10.16 | 7 | 91170 | 10686 | 29850615 |
| Nervous system neoplasm | 14.79 | 10.16 | 8 | 91169 | 154 | 29861147 |
| Bronchial disorder | 14.77 | 10.16 | 16 | 91161 | 898 | 29860403 |
| Thrombotic microangiopathy | 14.69 | 10.16 | 4 | 91173 | 8606 | 29852695 |
| Back injury | 14.68 | 10.16 | 33 | 91144 | 3512 | 29857789 |
| Psychotic disorder | 14.58 | 10.16 | 27 | 91150 | 21488 | 29839813 |
| Hepatic haematoma | 14.56 | 10.16 | 12 | 91165 | 476 | 29860825 |
| Infective exacerbation of chronic obstructive airways disease | 14.55 | 10.16 | 20 | 91157 | 1438 | 29859863 |
| Pyrexia | 14.47 | 10.16 | 741 | 90436 | 293748 | 29567553 |
| Suicide attempt | 14.43 | 10.16 | 60 | 91117 | 36637 | 29824664 |
| Nasal polypectomy | 14.39 | 10.16 | 3 | 91174 | 0 | 29861301 |
| Bradycardia | 14.27 | 10.16 | 129 | 91048 | 65397 | 29795904 |
| Malpositioned teeth | 14.21 | 10.16 | 5 | 91172 | 31 | 29861270 |
| Rhinitis perennial | 14.21 | 10.16 | 7 | 91170 | 110 | 29861191 |
| Proteinuria | 14.11 | 10.16 | 17 | 91160 | 16128 | 29845173 |
| Increased bronchial secretion | 14.10 | 10.16 | 19 | 91158 | 1340 | 29859961 |
| Allergic sinusitis | 14.08 | 10.16 | 6 | 91171 | 66 | 29861235 |
| Atopy | 13.98 | 10.16 | 7 | 91170 | 114 | 29861187 |
| Pneumocystis jirovecii pneumonia | 13.95 | 10.16 | 19 | 91158 | 17101 | 29844200 |
| Administration site swelling | 13.91 | 10.16 | 8 | 91169 | 174 | 29861127 |
| Restlessness | 13.90 | 10.16 | 30 | 91147 | 22569 | 29838732 |
| Necrotising oesophagitis | 13.86 | 10.16 | 11 | 91166 | 413 | 29860888 |
| Nocturnal dyspnoea | 13.85 | 10.16 | 12 | 91165 | 510 | 29860791 |
| Sleep terror | 13.78 | 10.16 | 14 | 91163 | 729 | 29860572 |
| Hepatocellular carcinoma | 13.75 | 10.16 | 6 | 91171 | 9604 | 29851697 |
| Transaminases increased | 13.73 | 10.16 | 32 | 91145 | 23425 | 29837876 |
| Metabolic acidosis | 13.67 | 10.16 | 63 | 91114 | 37398 | 29823903 |
| Cortisol abnormal | 13.58 | 10.16 | 5 | 91172 | 36 | 29861265 |
| Lung disorder | 13.53 | 10.16 | 151 | 91026 | 31318 | 29829983 |
| Tubulointerstitial nephritis | 13.46 | 10.16 | 21 | 91156 | 17870 | 29843431 |
| Panic reaction | 13.42 | 10.16 | 19 | 91158 | 1404 | 29859897 |
| Increased upper airway secretion | 13.41 | 10.16 | 21 | 91156 | 1699 | 29859602 |
| Drug level increased | 13.37 | 10.16 | 22 | 91155 | 18332 | 29842969 |
| Blood alkaline phosphatase increased | 13.32 | 10.16 | 50 | 91127 | 31437 | 29829864 |
| Deformity thorax | 13.23 | 10.16 | 5 | 91172 | 39 | 29861262 |
| Liver injury | 13.19 | 10.16 | 11 | 91166 | 12389 | 29848912 |
| Polyp | 13.08 | 10.16 | 30 | 91147 | 3236 | 29858065 |
| Encephalopathy | 13.07 | 10.16 | 52 | 91125 | 32153 | 29829148 |
| Epilepsy | 13.06 | 10.16 | 26 | 91151 | 20143 | 29841158 |
| Lung transplant | 13.04 | 10.16 | 22 | 91155 | 1894 | 29859407 |
| Aspirin-exacerbated respiratory disease | 13.04 | 10.16 | 10 | 91167 | 357 | 29860944 |
| Personality change | 12.96 | 10.16 | 37 | 91140 | 4563 | 29856738 |
| Tendon calcification | 12.91 | 10.16 | 5 | 91172 | 42 | 29861259 |
| Status epilepticus | 12.82 | 10.16 | 9 | 91168 | 11063 | 29850238 |
| Dyspnoea at rest | 12.80 | 10.16 | 26 | 91151 | 2580 | 29858721 |
| Hilar lymphadenopathy | 12.71 | 10.16 | 14 | 91163 | 801 | 29860500 |
| Hepatitis | 12.69 | 10.16 | 31 | 91146 | 22325 | 29838976 |
| Infective exacerbation of bronchiectasis | 12.65 | 10.16 | 11 | 91166 | 470 | 29860831 |
| Palmar-plantar erythrodysaesthesia syndrome | 12.63 | 10.16 | 16 | 91161 | 14854 | 29846447 |
| Spirometry abnormal | 12.56 | 10.16 | 9 | 91168 | 289 | 29861012 |
| Crepitations | 12.36 | 10.16 | 28 | 91149 | 2996 | 29858305 |
| Pre-existing condition improved | 12.35 | 10.16 | 22 | 91155 | 1979 | 29859322 |
| Eosinophilic bronchitis | 12.33 | 10.16 | 5 | 91172 | 48 | 29861253 |
| Forced expiratory volume abnormal | 12.32 | 10.16 | 3 | 91174 | 3 | 29861298 |
| Viral upper respiratory tract infection | 12.31 | 10.16 | 26 | 91151 | 2652 | 29858649 |
| Neutropenic sepsis | 12.28 | 10.16 | 10 | 91167 | 11399 | 29849902 |
| Aphonia | 12.23 | 10.16 | 28 | 91149 | 3016 | 29858285 |
| Neck pain | 12.17 | 10.16 | 107 | 91070 | 20837 | 29840464 |
| Flour sensitivity | 12.15 | 10.16 | 5 | 91172 | 50 | 29861251 |
| Extra dose administered | 12.10 | 10.16 | 27 | 91150 | 2859 | 29858442 |
| Graft versus host disease | 12.09 | 10.16 | 8 | 91169 | 10142 | 29851159 |
| Seizure | 12.05 | 10.16 | 219 | 90958 | 98256 | 29763045 |
| Epidural lipomatosis | 12 | 10.16 | 8 | 91169 | 228 | 29861073 |
| Respiratory tract oedema | 12.00 | 10.16 | 10 | 91167 | 403 | 29860898 |
| Disease progression | 11.98 | 10.16 | 171 | 91006 | 79703 | 29781598 |
| Stevens-Johnson syndrome | 11.92 | 10.16 | 22 | 91155 | 17534 | 29843767 |
| Throat clearing | 11.88 | 10.16 | 8 | 91169 | 232 | 29861069 |
| Drug eruption | 11.87 | 10.16 | 22 | 91155 | 17504 | 29843797 |
| Bronchitis bacterial | 11.84 | 10.16 | 13 | 91164 | 741 | 29860560 |
| Pseudomonas infection | 11.77 | 10.16 | 63 | 91114 | 10419 | 29850882 |
| Feeling of body temperature change | 11.75 | 10.16 | 17 | 91160 | 1282 | 29860019 |
| Infusion site swelling | 11.60 | 10.16 | 19 | 91158 | 1597 | 29859704 |
| Posterior reversible encephalopathy syndrome | 11.59 | 10.16 | 6 | 91171 | 8701 | 29852600 |
| Prothrombin time prolonged | 11.54 | 10.16 | 7 | 91170 | 9296 | 29852005 |
| Abnormal behaviour | 11.50 | 10.16 | 124 | 91053 | 25499 | 29835802 |
| Ischaemic stroke | 11.41 | 10.16 | 20 | 91157 | 16255 | 29845046 |
| Haemophilus infection | 11.40 | 10.16 | 14 | 91163 | 900 | 29860401 |
| Ligament sprain | 11.40 | 10.16 | 26 | 91151 | 2794 | 29858507 |
| Ventricular tachycardia | 11.37 | 10.16 | 36 | 91141 | 23826 | 29837475 |
| Lymphopenia | 11.35 | 10.16 | 14 | 91163 | 13149 | 29848152 |
| Back pain | 11.34 | 10.16 | 400 | 90777 | 102196 | 29759105 |
| Spinal osteoarthritis | 11.34 | 10.16 | 44 | 91133 | 6355 | 29854946 |
| Plasma cell myeloma | 11.31 | 10.16 | 106 | 91071 | 53356 | 29807945 |
| Pulmonary congestion | 11.28 | 10.16 | 70 | 91107 | 12217 | 29849084 |
| Dermatitis atopic | 11.23 | 10.16 | 15 | 91162 | 1049 | 29860252 |
| Pulmonary artery dilatation | 11.21 | 10.16 | 6 | 91171 | 113 | 29861188 |
| Haemolysis | 11.19 | 10.16 | 4 | 91173 | 7227 | 29854074 |
| Blood pressure diastolic decreased | 11.17 | 10.16 | 43 | 91134 | 6188 | 29855113 |
| Diarrhoea | 11.14 | 10.16 | 871 | 90306 | 333232 | 29528069 |
| Acidosis | 11.13 | 10.16 | 9 | 91168 | 10292 | 29851009 |
| ACTH stimulation test abnormal | 11.12 | 10.16 | 3 | 91174 | 6 | 29861295 |
| Plethoric face | 11.12 | 10.16 | 3 | 91174 | 6 | 29861295 |
| Administration site pain | 11.07 | 10.16 | 7 | 91170 | 182 | 29861119 |
| Respiratory distress | 11.06 | 10.16 | 151 | 91026 | 32821 | 29828480 |
| Intentional self-injury | 11.04 | 10.16 | 15 | 91162 | 13517 | 29847784 |
| Ileus | 11.01 | 10.16 | 19 | 91158 | 15536 | 29845765 |
| Acute myeloid leukaemia | 11.00 | 10.16 | 24 | 91153 | 17982 | 29843319 |
| Pathogen resistance | 10.90 | 10.16 | 6 | 91171 | 8404 | 29852897 |
| Diabetic ketoacidosis | 10.88 | 10.16 | 20 | 91157 | 15966 | 29845335 |
| Eye swelling | 10.84 | 10.16 | 55 | 91122 | 8909 | 29852392 |
| Eye irritation | 10.78 | 10.16 | 40 | 91137 | 5656 | 29855645 |
| Substance abuse | 10.72 | 10.16 | 4 | 91173 | 7036 | 29854265 |
| Nausea | 10.72 | 10.16 | 769 | 90408 | 296188 | 29565113 |
| Viral infection | 10.67 | 10.16 | 81 | 91096 | 15104 | 29846197 |
| Infusion site pruritus | 10.55 | 10.16 | 11 | 91166 | 591 | 29860710 |
| Cytopenia | 10.54 | 10.16 | 6 | 91171 | 8250 | 29853051 |
| Victim of child abuse | 10.52 | 10.16 | 8 | 91169 | 282 | 29861019 |
| Muscle spasms | 10.48 | 10.16 | 265 | 90912 | 64573 | 29796728 |
| Electrocardiogram QT prolonged | 10.44 | 10.16 | 65 | 91112 | 35770 | 29825531 |
| Hypohidrosis | 10.33 | 10.16 | 7 | 91170 | 205 | 29861096 |
| Oral mucosal blistering | 10.31 | 10.16 | 19 | 91158 | 1754 | 29859547 |
| Enuresis | 10.30 | 10.16 | 19 | 91158 | 1755 | 29859546 |
| Cystic fibrosis related diabetes | 10.29 | 10.16 | 6 | 91171 | 134 | 29861167 |
| Toxic skin eruption | 10.27 | 10.16 | 11 | 91166 | 11004 | 29850297 |
| Alpha-1 antitrypsin deficiency | 10.26 | 10.16 | 3 | 91174 | 9 | 29861292 |
| IPEX syndrome | 10.26 | 10.16 | 3 | 91174 | 9 | 29861292 |
| Neoplasm progression | 10.22 | 10.16 | 25 | 91152 | 17998 | 29843303 |
| Swollen tongue | 10.20 | 10.16 | 72 | 91105 | 13120 | 29848181 |
| CADASIL | 10.18 | 10.16 | 5 | 91172 | 78 | 29861223 |
| Ultrasound skull abnormal | 10.18 | 10.16 | 5 | 91172 | 78 | 29861223 |
| Pharyngeal erythema | 10.16 | 10.16 | 10 | 91167 | 501 | 29860800 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D07AC17 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III) |
| ATC | R01AD08 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
| ATC | R01AD58 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
| ATC | R03AK06 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
| ATC | R03AK11 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
| ATC | R03BA05 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids |
| CHEBI has role | CHEBI:49167 | anti-asthmatic agents |
| CHEBI has role | CHEBI:50857 | anti-allergic agents |
| MeSH PA | D018926 | Anti-Allergic Agents |
| MeSH PA | D018927 | Anti-Asthmatic Agents |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D001993 | Bronchodilator Agents |
| MeSH PA | D003879 | Dermatologic Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D019141 | Respiratory System Agents |
| FDA EPC | N0000175576 | Corticosteroid |
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:35523 | bronchodilator agents |
| CHEBI has role | CHEBI:37962 | adrenergic neuron agents |
| CHEBI has role | CHEBI:50177 | dermatological agent |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Atopic dermatitis | indication | 24079001 | DOID:3310 |
| Contact dermatitis | indication | 40275004 | DOID:2773 |
| Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
| Lichen simplex chronicus | indication | 53891004 | |
| Allergic rhinitis | indication | 61582004 | |
| Granuloma annulare | indication | 65508009 | DOID:3777 |
| Pulmonary emphysema | indication | 87433001 | |
| Pruritus ani | indication | 90446007 | |
| Discoid lupus erythematosus | indication | 200938002 | |
| Plaque psoriasis | indication | 200965009 | |
| Scalp psoriasis | indication | 238608008 | |
| Non-allergic asthma | indication | 266361008 | DOID:9360 |
| Pruritus of genital organs | indication | 267802000 | |
| Eruption of skin | indication | 271807003 | DOID:0050486 |
| Allergic asthma | indication | 389145006 | DOID:9415 |
| Primary cutaneous T-cell lymphoma | indication | 400122007 | |
| Asthma management | indication | 406162001 | |
| Bronchospasm Prevention with COPD | indication | ||
| Chronic Non-Allergic Rhinitis | indication | ||
| COPD Associated with Chronic Bronchitis | indication | ||
| Severe chronic obstructive pulmonary disease | off-label use | 313299006 | |
| Mycosis | contraindication | 3218000 | DOID:1564 |
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Inactive tuberculosis | contraindication | 11999007 | |
| Epistaxis | contraindication | 12441001 | |
| Measles | contraindication | 14189004 | DOID:8622 |
| Disease caused by parasite | contraindication | 17322007 | |
| Glaucoma | contraindication | 23986001 | DOID:1686 |
| Acute tuberculosis | contraindication | 25629007 | |
| Viral disease | contraindication | 34014006 | DOID:934 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Hypokalemia | contraindication | 43339004 | |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Hypercortisolism | contraindication | 47270006 | |
| Ketoacidosis | contraindication | 56051008 | |
| Osteoporosis | contraindication | 64859006 | DOID:11476 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Hypopituitarism | contraindication | 74728003 | DOID:9406 |
| Candidiasis of mouth | contraindication | 79740000 | DOID:14262 |
| Perforation of nasal septum | contraindication | 80142000 | |
| Hyperglycemia | contraindication | 80394007 | DOID:4195 |
| Bacterial infectious disease | contraindication | 87628006 | |
| Operation on nose | contraindication | 88733004 | |
| Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
| Bilateral cataracts | contraindication | 95722004 | |
| Prolonged QT interval | contraindication | 111975006 | |
| Seizure disorder | contraindication | 128613002 | |
| Pulmonary tuberculosis | contraindication | 154283005 | DOID:2957 |
| Ophthalmic herpes simplex | contraindication | 186542001 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Telangiectasia disorder | contraindication | 247479008 | |
| Exacerbation of asthma | contraindication | 281239006 | |
| Varicella-zoster virus infection | contraindication | 309465005 | |
| Osteopenia | contraindication | 312894000 | |
| Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
| Atrophoderma | contraindication | 399979006 | |
| Peripheral vascular disease | contraindication | 400047006 | |
| Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
| Congenital long QT syndrome | contraindication | 442917000 | |
| Exposure to varicella | contraindication | 444453009 | |
| Nasal Candidiasis | contraindication | ||
| Untreated Fungal Infection | contraindication | ||
| Uncontrolled Bacterial Infections | contraindication | ||
| Nasal Septal Ulcers | contraindication | ||
| Nasal Trauma | contraindication |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.49 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | EC50 | 10.74 | WOMBAT-PK | CHEMBL | |||
| Progesterone receptor | Nuclear hormone receptor | AGONIST | EC50 | 9.77 | WOMBAT-PK | ||||
| Cytosolic phospholipase A2 | Enzyme | WOMBAT-PK | |||||||
| Mineralocorticoid receptor | Nuclear hormone receptor | AGONIST | EC50 | 6.83 | IUPHAR | ||||
| Glucocorticoid receptor | Transcription factor | EC50 | 9.12 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020180 | VUID |
| N0000148122 | NUI |
| D01708 | KEGG_DRUG |
| 90566-53-3 | SECONDARY_CAS_RN |
| 4020180 | VANDF |
| 4020529 | VANDF |
| C0591521 | UMLSCUI |
| C0082607 | UMLSCUI |
| CHEBI:31441 | CHEBI |
| CHEBI:5134 | CHEBI |
| CHEMBL1473 | ChEMBL_ID |
| DB00588 | DRUGBANK_ID |
| D000068298 | MESH_DESCRIPTOR_UI |
| 7080 | IUPHAR_LIGAND_ID |
| 5636 | INN_ID |
| O2GMZ0LF5W | UNII |
| CUT2W21N7U | UNII |
| 444036 | PUBCHEM_CID |
| 5311101 | PUBCHEM_CID |
| 6699 | IUPHAR_LIGAND_ID |
| DB13867 | DRUGBANK_ID |
| 41126 | RXNORM |
| 4756 | MMSL |
| 51966 | MMSL |
| 81052 | MMSL |
| d01296 | MMSL |
| 003593 | NDDF |
| 004952 | NDDF |
| 108632003 | SNOMEDCT_US |
| 396064000 | SNOMEDCT_US |
| 397192001 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| DYMISTA | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0037-0245 | SPRAY, METERED | 50 ug | NULLSAL | NDA | 28 sections |
| fluticasone propionate and salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0054-0326 | POWDER | 100 ug | RESPIRATORY (INHALATION) | ANDA | 29 sections |
| fluticasone propionate and salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0054-0327 | POWDER | 250 ug | RESPIRATORY (INHALATION) | ANDA | 29 sections |
| Fluticasone Propionate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-3270 | SPRAY, METERED | 50 ug | NULLSAL | ANDA | 26 sections |
| Fluticasone Propionate and Salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-3607 | POWDER, METERED | 55 ug | RESPIRATORY (INHALATION) | NDA AUTHORIZED GENERIC | 28 sections |
| Fluticasone Propionate and Salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-3608 | POWDER, METERED | 113 ug | RESPIRATORY (INHALATION) | NDA AUTHORIZED GENERIC | 28 sections |
| Fluticasone Propionate and Salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-3609 | POWDER, METERED | 232 ug | RESPIRATORY (INHALATION) | NDA AUTHORIZED GENERIC | 28 sections |
| Good Sense 24 hour allergy nasal | HUMAN OTC DRUG LABEL | 1 | 0113-0028 | SPRAY, METERED | 50 ug | NULLSAL | ANDA | 17 sections |
| Good Sense 24 hour allergy nasal | HUMAN OTC DRUG LABEL | 1 | 0113-0285 | SPRAY, METERED | 50 ug | NULLSAL | ANDA | 17 sections |
| basic care allergy relief nasal | HUMAN OTC DRUG LABEL | 1 | 0113-7117 | SPRAY, METERED | 50 ug | NULLSAL | ANDA | 17 sections |
| FLONULLSEALLERGY RELIEF | HUMAN OTC DRUG LABEL | 1 | 0135-0576 | SPRAY, METERED | 50 ug | NULLSAL | NDA | 16 sections |
| CHILDRENS FLONULLSEALLERGY RELIEF | HUMAN OTC DRUG LABEL | 1 | 0135-0582 | SPRAY, METERED | 50 ug | NULLSAL | NDA | 16 sections |
| FLUTICASONE PROPIONULLTE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0332 | CREAM | 0.50 mg | TOPICAL | ANDA | 21 sections |
| Fluticasone Propionate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0333 | OINTMENT | 0.05 mg | TOPICAL | ANDA | 25 sections |
| FLUTICASONE PROPIONULLTE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0434 | LOTION | 0.50 mg | TOPICAL | NDA authorized generic | 26 sections |
| FLOVENTDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0600 | POWDER, METERED | 50 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
| FLOVENTDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0601 | POWDER, METERED | 250 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
| FLOVENTDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0602 | POWDER, METERED | 100 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
| ADVAIRDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0695 | POWDER | 100 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |
| ADVAIRDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0696 | POWDER | 250 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |
| ADVAIRDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0697 | POWDER | 500 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |
| ADVAIR HFA | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0715 | AEROSOL, METERED | 45 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
| ADVAIR HFA | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0716 | AEROSOL, METERED | 115 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
| ADVAIR HFA | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0717 | AEROSOL, METERED | 230 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
| FLOVENTHFA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0718 | AEROSOL, METERED | 44 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
| FLOVENTHFA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0719 | AEROSOL, METERED | 110 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
| FLOVENTHFA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0720 | AEROSOL, METERED | 220 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
| 24 Hour Allergy Nasal | HUMAN OTC DRUG LABEL | 1 | 0363-0024 | SPRAY, METERED | 50 ug | NULLSAL | ANDA | 17 sections |
| Fluticasone Propionate | HUMAN OTC DRUG LABEL | 1 | 0363-0652 | SPRAY, METERED | 50 ug | NULLSAL | ANDA | 16 sections |
| Allergy Nasal | HUMAN OTC DRUG LABEL | 1 | 0363-0881 | SPRAY, METERED | 50 ug | NULLSAL | ANDA | 17 sections |