Stem definition | Drug id | CAS RN |
---|---|---|
steroids not used as glucocorticosteroids | 1225 | 80474-14-2 |
Dose | Unit | Route |
---|---|---|
0.20 | mg | N |
0.60 | mg | Inhal.aerosol |
0.60 | mg | Inhal.powder |
1.50 | mg | Inhal.solution |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.00 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 3 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 6.65 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 1 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 3.60 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 17 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.10 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 6 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
March 26, 2021 | EMA | TEVA B.V. | |
Dec. 14, 1990 | FDA | FOUGERA PHARMS | |
June 29, 2020 | PMDA | Kyorin Pharmaceutical Co., Ltd. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 757.81 | 9.70 | 1044 | 130852 | 88293 | 50384935 |
Wheezing | 351.73 | 9.70 | 602 | 131294 | 61445 | 50411783 |
Completed suicide | 309.93 | 9.70 | 7 | 131889 | 131882 | 50341346 |
Contraindicated product administered | 279.37 | 9.70 | 31 | 131865 | 148927 | 50324301 |
Infective pulmonary exacerbation of cystic fibrosis | 261.66 | 9.70 | 194 | 131702 | 7715 | 50465513 |
Toxicity to various agents | 257.24 | 9.70 | 116 | 131780 | 212383 | 50260845 |
Cough | 251.69 | 9.70 | 1268 | 130628 | 239996 | 50233232 |
Synovitis | 250.37 | 9.70 | 19 | 131877 | 123846 | 50349382 |
Dyspnoea | 241.35 | 9.70 | 2328 | 129568 | 545280 | 49927948 |
Systemic lupus erythematosus | 221.32 | 9.70 | 48 | 131848 | 140574 | 50332654 |
Hand deformity | 218.77 | 9.70 | 10 | 131886 | 100189 | 50373039 |
Sinusitis | 202.66 | 9.70 | 931 | 130965 | 169627 | 50303601 |
Chest discomfort | 202.58 | 9.70 | 616 | 131280 | 92106 | 50381122 |
Bronchitis | 188.66 | 9.70 | 649 | 131247 | 103510 | 50369718 |
Glossodynia | 176.73 | 9.70 | 42 | 131854 | 115527 | 50357701 |
Chronic obstructive pulmonary disease | 170.08 | 9.70 | 408 | 131488 | 53027 | 50420201 |
Treatment failure | 157.49 | 9.70 | 81 | 131815 | 137556 | 50335672 |
Drug intolerance | 156.56 | 9.70 | 205 | 131691 | 218899 | 50254329 |
Product quality issue | 151.11 | 9.70 | 281 | 131615 | 30577 | 50442651 |
Pericarditis | 151.00 | 9.70 | 15 | 131881 | 78674 | 50394554 |
Eosinophilic granulomatosis with polyangiitis | 148.17 | 9.70 | 81 | 131815 | 1874 | 50471354 |
Off label use | 140.49 | 9.70 | 698 | 131198 | 473728 | 49999500 |
Joint swelling | 139.71 | 9.70 | 267 | 131629 | 245019 | 50228209 |
Wound | 138.86 | 9.70 | 51 | 131845 | 105743 | 50367485 |
Arthropathy | 134.37 | 9.70 | 128 | 131768 | 157778 | 50315450 |
Maternal exposure during pregnancy | 126.32 | 9.70 | 138 | 131758 | 159640 | 50313588 |
Alopecia | 125.81 | 9.70 | 283 | 131613 | 244764 | 50228464 |
Therapeutic product effect decreased | 122.05 | 9.70 | 105 | 131791 | 135945 | 50337283 |
Obstructive airways disorder | 119.25 | 9.70 | 174 | 131722 | 15478 | 50457750 |
Pneumonia | 119.20 | 9.70 | 1507 | 130389 | 376894 | 50096334 |
Drug ineffective | 114.12 | 9.70 | 1481 | 130415 | 817852 | 49655376 |
Hepatic enzyme increased | 113.82 | 9.70 | 114 | 131782 | 137266 | 50335962 |
Neutropenia | 110.24 | 9.70 | 134 | 131762 | 147831 | 50325397 |
Product dose omission issue | 107.85 | 9.70 | 834 | 131062 | 183004 | 50290224 |
General physical health deterioration | 106.10 | 9.70 | 129 | 131767 | 142305 | 50330923 |
Nasal congestion | 101.77 | 9.70 | 329 | 131567 | 50791 | 50422437 |
Drug abuse | 101.37 | 9.70 | 17 | 131879 | 59829 | 50413399 |
Intentional overdose | 98.96 | 9.70 | 21 | 131875 | 62483 | 50410745 |
Sleep apnoea syndrome | 98.19 | 9.70 | 202 | 131694 | 23666 | 50449562 |
Anxiety | 95.57 | 9.70 | 790 | 131106 | 176816 | 50296412 |
Helicobacter infection | 86.71 | 9.70 | 13 | 131883 | 49689 | 50423539 |
Sputum increased | 85.69 | 9.70 | 56 | 131840 | 1811 | 50471417 |
Upper respiratory tract infection | 85.09 | 9.70 | 369 | 131527 | 65529 | 50407699 |
Productive cough | 83.95 | 9.70 | 315 | 131581 | 52379 | 50420849 |
Muscle injury | 83.34 | 9.70 | 3 | 131893 | 37108 | 50436120 |
Rheumatoid arthritis | 83.34 | 9.70 | 261 | 131635 | 202289 | 50270939 |
Chronic sinusitis | 81.40 | 9.70 | 90 | 131806 | 6055 | 50467173 |
Folliculitis | 79.26 | 9.70 | 6 | 131890 | 39219 | 50434009 |
Nasal polyps | 78.59 | 9.70 | 60 | 131836 | 2494 | 50470734 |
Febrile neutropenia | 77.54 | 9.70 | 84 | 131812 | 97583 | 50375645 |
Macular degeneration | 76.75 | 9.70 | 136 | 131760 | 14252 | 50458976 |
Discomfort | 76.70 | 9.70 | 102 | 131794 | 108278 | 50364950 |
Thrombocytopenia | 76.12 | 9.70 | 135 | 131761 | 127538 | 50345690 |
Infusion related reaction | 73.67 | 9.70 | 213 | 131683 | 169344 | 50303884 |
Dysphonia | 70.90 | 9.70 | 243 | 131653 | 38649 | 50434579 |
Adrenal suppression | 68.50 | 9.70 | 37 | 131859 | 835 | 50472393 |
Sleep disorder due to a general medical condition | 66.68 | 9.70 | 89 | 131807 | 7282 | 50465946 |
Swelling | 65.45 | 9.70 | 285 | 131611 | 200587 | 50272641 |
Sleep disorder due to general medical condition, insomnia type | 63.00 | 9.70 | 5 | 131891 | 31442 | 50441786 |
Gastrooesophageal reflux disease | 62.82 | 9.70 | 377 | 131519 | 76051 | 50397177 |
Acute kidney injury | 59.80 | 9.70 | 349 | 131547 | 227709 | 50245519 |
Leukopenia | 58.26 | 9.70 | 54 | 131842 | 67474 | 50405754 |
Malignant neoplasm progression | 58.16 | 9.70 | 55 | 131841 | 68069 | 50405159 |
Product complaint | 58.11 | 9.70 | 106 | 131790 | 11360 | 50461868 |
Pancytopenia | 56.53 | 9.70 | 82 | 131814 | 83948 | 50389280 |
Rhinitis allergic | 56.24 | 9.70 | 81 | 131815 | 7119 | 50466109 |
Dyspnoea exertional | 54.41 | 9.70 | 271 | 131625 | 50962 | 50422266 |
Bronchial neoplasm | 53.58 | 9.70 | 25 | 131871 | 408 | 50472820 |
Abdominal discomfort | 53.28 | 9.70 | 369 | 131527 | 231272 | 50241956 |
Bronchial haemorrhage | 52.16 | 9.70 | 26 | 131870 | 494 | 50472734 |
Emotional distress | 50.42 | 9.70 | 177 | 131719 | 28486 | 50444742 |
Feeling abnormal | 50.18 | 9.70 | 524 | 131372 | 124968 | 50348260 |
Respiratory symptom | 49.83 | 9.70 | 45 | 131851 | 2369 | 50470859 |
Coma | 49.64 | 9.70 | 45 | 131851 | 56834 | 50416394 |
Drug interaction | 49.42 | 9.70 | 311 | 131585 | 199310 | 50273918 |
Pulmonary function test decreased | 49.04 | 9.70 | 52 | 131844 | 3336 | 50469892 |
Nasal turbinate hypertrophy | 48.68 | 9.70 | 27 | 131869 | 643 | 50472585 |
Mucosal inflammation | 48.35 | 9.70 | 22 | 131874 | 40120 | 50433108 |
Migraine | 48.29 | 9.70 | 349 | 131547 | 74931 | 50398297 |
Hepatotoxicity | 47.76 | 9.70 | 7 | 131889 | 27219 | 50446009 |
Seasonal allergy | 47.68 | 9.70 | 113 | 131783 | 14563 | 50458665 |
Chest pain | 47.06 | 9.70 | 684 | 131212 | 176198 | 50297030 |
Cystic fibrosis | 46.95 | 9.70 | 47 | 131849 | 2817 | 50470411 |
Emphysema | 46.00 | 9.70 | 84 | 131812 | 9009 | 50464219 |
Blister | 45.94 | 9.70 | 96 | 131800 | 85322 | 50387906 |
Forced expiratory volume decreased | 45.94 | 9.70 | 57 | 131839 | 4337 | 50468891 |
Rhonchi | 45.66 | 9.70 | 42 | 131854 | 2265 | 50470963 |
Salpingo-oophorectomy unilateral | 45.44 | 9.70 | 24 | 131872 | 517 | 50472711 |
Rhinorrhoea | 45.32 | 9.70 | 259 | 131637 | 51324 | 50421904 |
Full blood count abnormal | 45.16 | 9.70 | 149 | 131747 | 23239 | 50449989 |
Hepatic function abnormal | 44.15 | 9.70 | 15 | 131881 | 32666 | 50440562 |
Drug reaction with eosinophilia and systemic symptoms | 44.07 | 9.70 | 10 | 131886 | 28414 | 50444814 |
Impaired healing | 43.21 | 9.70 | 72 | 131824 | 69714 | 50403514 |
Sinusitis fungal | 43.11 | 9.70 | 32 | 131864 | 1274 | 50471954 |
Depression | 42.94 | 9.70 | 637 | 131259 | 164786 | 50308442 |
Gamma-glutamyltransferase increased | 42.89 | 9.70 | 12 | 131884 | 29611 | 50443617 |
Sinus disorder | 42.49 | 9.70 | 125 | 131771 | 18333 | 50454895 |
Bronchial disorder | 42.29 | 9.70 | 30 | 131866 | 1112 | 50472116 |
Multiple organ dysfunction syndrome | 41.39 | 9.70 | 42 | 131854 | 50295 | 50422933 |
Nasal discomfort | 41.39 | 9.70 | 51 | 131845 | 3853 | 50469375 |
Cushing's syndrome | 41.39 | 9.70 | 24 | 131872 | 624 | 50472604 |
Sputum discoloured | 41.22 | 9.70 | 101 | 131795 | 13294 | 50459934 |
Headache | 41.07 | 9.70 | 1661 | 130235 | 504874 | 49968354 |
Oropharyngeal pain | 40.67 | 9.70 | 344 | 131552 | 77457 | 50395771 |
Injury | 40.61 | 9.70 | 242 | 131654 | 48683 | 50424545 |
Diverticulum | 40.36 | 9.70 | 87 | 131809 | 10527 | 50462701 |
Bone erosion | 40.17 | 9.70 | 92 | 131804 | 11595 | 50461633 |
Cholecystitis chronic | 39.96 | 9.70 | 82 | 131814 | 9587 | 50463641 |
Cardio-respiratory arrest | 39.89 | 9.70 | 49 | 131847 | 53843 | 50419385 |
Endometrial ablation | 39.89 | 9.70 | 26 | 131870 | 837 | 50472391 |
Rhinitis | 39.88 | 9.70 | 75 | 131821 | 8226 | 50465002 |
Musculoskeletal stiffness | 39.59 | 9.70 | 186 | 131710 | 128295 | 50344933 |
Overdose | 39.23 | 9.70 | 131 | 131765 | 99596 | 50373632 |
Deep vein thrombosis | 38.25 | 9.70 | 324 | 131572 | 72980 | 50400248 |
Acute respiratory failure | 37.77 | 9.70 | 162 | 131734 | 28620 | 50444608 |
Dizziness | 37.47 | 9.70 | 1174 | 130722 | 345195 | 50128033 |
Adrenal insufficiency | 37.23 | 9.70 | 101 | 131795 | 14142 | 50459086 |
Dermatitis allergic | 37.13 | 9.70 | 94 | 131802 | 12626 | 50460602 |
Upper-airway cough syndrome | 37.11 | 9.70 | 74 | 131822 | 8476 | 50464752 |
Ear infection | 37.07 | 9.70 | 150 | 131746 | 25820 | 50447408 |
Embolism venous | 36.98 | 9.70 | 39 | 131857 | 2486 | 50470742 |
Prolonged expiration | 36.49 | 9.70 | 23 | 131873 | 698 | 50472530 |
Multiple allergies | 36.43 | 9.70 | 73 | 131823 | 8390 | 50464838 |
Bone marrow failure | 35.09 | 9.70 | 14 | 131882 | 27610 | 50445618 |
Viral infection | 35.00 | 9.70 | 163 | 131733 | 29823 | 50443405 |
Influenza | 34.90 | 9.70 | 372 | 131524 | 89166 | 50384062 |
Metabolic acidosis | 34.74 | 9.70 | 30 | 131866 | 38795 | 50434433 |
Increased upper airway secretion | 33.21 | 9.70 | 41 | 131855 | 3103 | 50470125 |
Ectropion | 32.37 | 9.70 | 13 | 131883 | 144 | 50473084 |
Drug hypersensitivity | 32.35 | 9.70 | 460 | 131436 | 250550 | 50222678 |
C-reactive protein increased | 32.25 | 9.70 | 79 | 131817 | 66395 | 50406833 |
Product use issue | 31.97 | 9.70 | 243 | 131653 | 149232 | 50323996 |
Platelet count decreased | 31.51 | 9.70 | 145 | 131751 | 100581 | 50372647 |
Pre-existing condition improved | 31.49 | 9.70 | 62 | 131834 | 7035 | 50466193 |
Anaemia | 31.36 | 9.70 | 466 | 131430 | 251990 | 50221238 |
Toxic epidermal necrolysis | 31.34 | 9.70 | 8 | 131888 | 20984 | 50452244 |
Candida infection | 31.33 | 9.70 | 133 | 131763 | 23390 | 50449838 |
Palpitations | 31.13 | 9.70 | 380 | 131516 | 94126 | 50379102 |
Pulmonary embolism | 30.97 | 9.70 | 403 | 131493 | 101301 | 50371927 |
Acute sinusitis | 30.70 | 9.70 | 42 | 131854 | 3518 | 50469710 |
Death | 30.69 | 9.70 | 631 | 131265 | 324748 | 50148480 |
Dermatitis atopic | 30.46 | 9.70 | 42 | 131854 | 3544 | 50469684 |
Bladder prolapse | 30.06 | 9.70 | 30 | 131866 | 1791 | 50471437 |
Infusion site swelling | 29.82 | 9.70 | 61 | 131835 | 7115 | 50466113 |
Liver injury | 29.24 | 9.70 | 14 | 131882 | 24792 | 50448436 |
Infusion site erythema | 29.22 | 9.70 | 68 | 131828 | 8659 | 50464569 |
Eczema | 29.19 | 9.70 | 127 | 131769 | 22575 | 50450653 |
Cholestasis | 28.94 | 9.70 | 15 | 131881 | 25386 | 50447842 |
Hiatus hernia | 28.65 | 9.70 | 109 | 131787 | 18235 | 50454993 |
Agranulocytosis | 28.64 | 9.70 | 10 | 131886 | 21411 | 50451817 |
Hepatocellular injury | 28.58 | 9.70 | 16 | 131880 | 25931 | 50447297 |
Foetal exposure during pregnancy | 28.54 | 9.70 | 18 | 131878 | 27341 | 50445887 |
Bronchial obstruction | 28.52 | 9.70 | 25 | 131871 | 1265 | 50471963 |
Concussion | 28.40 | 9.70 | 62 | 131834 | 7566 | 50465662 |
Pulmonary mass | 28.28 | 9.70 | 110 | 131786 | 18595 | 50454633 |
Diastolic dysfunction | 28.12 | 9.70 | 50 | 131846 | 5252 | 50467976 |
Throat irritation | 27.99 | 9.70 | 154 | 131742 | 30085 | 50443143 |
Gastrointestinal disorder | 27.78 | 9.70 | 139 | 131757 | 94317 | 50378911 |
Anosmia | 27.50 | 9.70 | 42 | 131854 | 3889 | 50469339 |
Renal impairment | 26.69 | 9.70 | 104 | 131792 | 75557 | 50397671 |
Status asthmaticus | 26.58 | 9.70 | 20 | 131876 | 813 | 50472415 |
Eosinophil count increased | 26.56 | 9.70 | 66 | 131830 | 8764 | 50464464 |
Cytomegalovirus infection | 26.52 | 9.70 | 7 | 131889 | 17955 | 50455273 |
Nasal mucosal disorder | 26.47 | 9.70 | 15 | 131881 | 373 | 50472855 |
Breath sounds abnormal | 26.40 | 9.70 | 61 | 131835 | 7731 | 50465497 |
Suicide attempt | 26.27 | 9.70 | 60 | 131836 | 51672 | 50421556 |
Oropharyngeal oedema | 26.27 | 9.70 | 13 | 131883 | 243 | 50472985 |
Poor quality device used | 26.07 | 9.70 | 28 | 131868 | 1823 | 50471405 |
Posterior reversible encephalopathy syndrome | 25.81 | 9.70 | 4 | 131892 | 14924 | 50458304 |
Depressed level of consciousness | 25.79 | 9.70 | 61 | 131835 | 51892 | 50421336 |
Hyponatraemia | 25.22 | 9.70 | 147 | 131749 | 95992 | 50377236 |
Pneumocystis jirovecii pneumonia | 25.19 | 9.70 | 4 | 131892 | 14659 | 50458569 |
Urinary tract infection | 25.15 | 9.70 | 763 | 131133 | 223257 | 50249971 |
Serotonin syndrome | 24.78 | 9.70 | 17 | 131879 | 24696 | 50448532 |
Neutrophil count decreased | 24.51 | 9.70 | 52 | 131844 | 45974 | 50427254 |
Heart sounds | 24.38 | 9.70 | 17 | 131879 | 613 | 50472615 |
Oesophageal spasm | 24.35 | 9.70 | 30 | 131866 | 2266 | 50470962 |
Burning sensation | 24.30 | 9.70 | 202 | 131694 | 45244 | 50427984 |
Rash | 24.29 | 9.70 | 914 | 130982 | 436557 | 50036671 |
Electrocardiogram QT prolonged | 24.13 | 9.70 | 63 | 131833 | 51823 | 50421405 |
Rectal prolapse | 23.83 | 9.70 | 26 | 131870 | 1723 | 50471505 |
Premature baby | 23.77 | 9.70 | 9 | 131887 | 18328 | 50454900 |
Tricuspid valve incompetence | 23.45 | 9.70 | 80 | 131816 | 12690 | 50460538 |
Oesophagogastroduodenoscopy | 22.97 | 9.70 | 9 | 131887 | 93 | 50473135 |
Irritable bowel syndrome | 22.76 | 9.70 | 64 | 131832 | 51377 | 50421851 |
Exposure during pregnancy | 22.56 | 9.70 | 204 | 131692 | 120811 | 50352417 |
Pruritus | 22.45 | 9.70 | 928 | 130968 | 282640 | 50190588 |
Expiratory reserve volume decreased | 22.38 | 9.70 | 7 | 131889 | 34 | 50473194 |
Granuloma | 22.24 | 9.70 | 43 | 131853 | 4815 | 50468413 |
Interstitial lung disease | 22.20 | 9.70 | 68 | 131828 | 53108 | 50420120 |
Throat clearing | 22.15 | 9.70 | 21 | 131875 | 1177 | 50472051 |
Bronchitis bacterial | 22.07 | 9.70 | 17 | 131879 | 716 | 50472512 |
Illness | 22.06 | 9.70 | 124 | 131772 | 24416 | 50448812 |
Therapeutic response unexpected | 21.98 | 9.70 | 91 | 131805 | 15824 | 50457404 |
Hypotension | 21.77 | 9.70 | 458 | 131438 | 235011 | 50238217 |
Croup infectious | 21.75 | 9.70 | 14 | 131882 | 441 | 50472787 |
Inhalation therapy | 21.59 | 9.70 | 7 | 131889 | 39 | 50473189 |
Eosinophilic pneumonia chronic | 21.33 | 9.70 | 10 | 131886 | 165 | 50473063 |
Infusion site nodule | 21.30 | 9.70 | 20 | 131876 | 1107 | 50472121 |
Bradycardia | 21.19 | 9.70 | 91 | 131805 | 64335 | 50408893 |
Oesophageal pain | 21.12 | 9.70 | 31 | 131865 | 2771 | 50470457 |
Bronchial wall thickening | 20.94 | 9.70 | 18 | 131878 | 887 | 50472341 |
Haemoptysis | 20.90 | 9.70 | 126 | 131770 | 25447 | 50447781 |
Infusion site haemorrhage | 20.88 | 9.70 | 32 | 131864 | 2972 | 50470256 |
Altered state of consciousness | 20.76 | 9.70 | 16 | 131880 | 21894 | 50451334 |
Peak expiratory flow rate decreased | 20.75 | 9.70 | 15 | 131881 | 573 | 50472655 |
Rheumatoid nodule | 20.73 | 9.70 | 4 | 131892 | 12731 | 50460497 |
Cor pulmonale | 20.57 | 9.70 | 25 | 131871 | 1862 | 50471366 |
Myelosuppression | 20.47 | 9.70 | 5 | 131891 | 13512 | 50459716 |
Biliary dyskinesia | 20.37 | 9.70 | 29 | 131867 | 2521 | 50470707 |
Respiratory tract infection | 20.27 | 9.70 | 148 | 131748 | 31869 | 50441359 |
Confusional state | 20.14 | 9.70 | 352 | 131544 | 185576 | 50287652 |
Female genital tract fistula | 20.00 | 9.70 | 35 | 131861 | 3631 | 50469597 |
Neutropenic sepsis | 19.98 | 9.70 | 6 | 131890 | 14141 | 50459087 |
Circulatory collapse | 19.73 | 9.70 | 14 | 131882 | 19986 | 50453242 |
Lymphopenia | 19.70 | 9.70 | 8 | 131888 | 15613 | 50457615 |
Toxic skin eruption | 19.49 | 9.70 | 3 | 131893 | 11248 | 50461980 |
Respiratory arrest | 19.48 | 9.70 | 30 | 131866 | 29979 | 50443249 |
Eosinophil count abnormal | 19.21 | 9.70 | 13 | 131883 | 446 | 50472782 |
Pulmonary hypertension | 19.20 | 9.70 | 151 | 131745 | 33266 | 50439962 |
Aphonia | 19.12 | 9.70 | 57 | 131839 | 8421 | 50464807 |
Blood immunoglobulin E increased | 19.10 | 9.70 | 27 | 131869 | 2332 | 50470896 |
Drug eruption | 19.06 | 9.70 | 20 | 131876 | 23586 | 50449642 |
Bronchospasm | 19.02 | 9.70 | 83 | 131813 | 14771 | 50458457 |
Hyperkalaemia | 19.02 | 9.70 | 63 | 131833 | 48026 | 50425202 |
Muscle spasms | 18.77 | 9.70 | 444 | 131452 | 125109 | 50348119 |
Hospitalisation | 18.54 | 9.70 | 264 | 131632 | 67673 | 50405555 |
Stress | 18.45 | 9.70 | 218 | 131678 | 53575 | 50419653 |
Hip arthroplasty | 18.27 | 9.70 | 32 | 131864 | 30397 | 50442831 |
Premature delivery | 18.06 | 9.70 | 21 | 131875 | 23642 | 50449586 |
Affective disorder | 18.04 | 9.70 | 41 | 131855 | 5140 | 50468088 |
Mobility decreased | 18.02 | 9.70 | 128 | 131768 | 79820 | 50393408 |
Cystic fibrosis related diabetes | 17.99 | 9.70 | 6 | 131890 | 37 | 50473191 |
Growth failure | 17.90 | 9.70 | 11 | 131885 | 319 | 50472909 |
Neurotoxicity | 17.87 | 9.70 | 8 | 131888 | 14732 | 50458496 |
Iron deficiency anaemia | 17.83 | 9.70 | 89 | 131807 | 16745 | 50456483 |
Oxygen saturation decreased | 17.79 | 9.70 | 279 | 131617 | 72969 | 50400259 |
Hysterectomy | 17.75 | 9.70 | 53 | 131843 | 7837 | 50465391 |
Sinus operation | 17.73 | 9.70 | 22 | 131874 | 1674 | 50471554 |
Bronchiectasis | 17.65 | 9.70 | 63 | 131833 | 10220 | 50463008 |
Blood lactate dehydrogenase increased | 17.64 | 9.70 | 15 | 131881 | 19547 | 50453681 |
Influenza like illness | 17.61 | 9.70 | 228 | 131668 | 57231 | 50415997 |
Eye pruritus | 17.57 | 9.70 | 72 | 131824 | 12462 | 50460766 |
Jaundice | 17.56 | 9.70 | 26 | 131870 | 26403 | 50446825 |
Gallbladder disorder | 17.37 | 9.70 | 88 | 131808 | 16654 | 50456574 |
Cortisol decreased | 17.29 | 9.70 | 17 | 131879 | 997 | 50472231 |
Ankle fracture | 17.28 | 9.70 | 84 | 131812 | 15638 | 50457590 |
Urticaria | 17.23 | 9.70 | 451 | 131445 | 129110 | 50344118 |
Metastases to bone | 17.23 | 9.70 | 13 | 131883 | 17982 | 50455246 |
Tinnitus | 17.21 | 9.70 | 129 | 131767 | 28003 | 50445225 |
Thyroid atrophy | 17.18 | 9.70 | 5 | 131891 | 18 | 50473210 |
Nodular vasculitis | 17.18 | 9.70 | 5 | 131891 | 18 | 50473210 |
Intentional self-injury | 17.12 | 9.70 | 21 | 131875 | 23091 | 50450137 |
Fracture displacement | 17.02 | 9.70 | 18 | 131878 | 1151 | 50472077 |
Infusion site pruritus | 17.00 | 9.70 | 34 | 131862 | 3903 | 50469325 |
Total lung capacity abnormal | 16.99 | 9.70 | 6 | 131890 | 45 | 50473183 |
Cardiac arrest | 16.94 | 9.70 | 138 | 131758 | 83513 | 50389715 |
Live birth | 16.83 | 9.70 | 11 | 131885 | 16397 | 50456831 |
Sinus headache | 16.70 | 9.70 | 37 | 131859 | 4561 | 50468667 |
Blood creatinine increased | 16.65 | 9.70 | 123 | 131773 | 76037 | 50397191 |
Infusion site pain | 16.59 | 9.70 | 70 | 131826 | 12276 | 50460952 |
Hypoxia | 16.58 | 9.70 | 205 | 131691 | 50918 | 50422310 |
Surgery | 16.54 | 9.70 | 135 | 131761 | 30070 | 50443158 |
Hypokalaemia | 16.54 | 9.70 | 148 | 131748 | 87844 | 50385384 |
Disease progression | 16.42 | 9.70 | 165 | 131731 | 95701 | 50377527 |
Exposure to SARS-CoV-2 | 16.15 | 9.70 | 13 | 131883 | 584 | 50472644 |
Shock | 16.11 | 9.70 | 18 | 131878 | 20632 | 50452596 |
Intentional product use issue | 15.98 | 9.70 | 126 | 131770 | 76792 | 50396436 |
Hepatic failure | 15.94 | 9.70 | 38 | 131858 | 32245 | 50440983 |
Weight decreased | 15.70 | 9.70 | 716 | 131180 | 220529 | 50252699 |
Pneumococcal infection | 15.67 | 9.70 | 11 | 131885 | 401 | 50472827 |
Hereditary angioedema | 15.66 | 9.70 | 40 | 131856 | 5402 | 50467826 |
FEV1/FVC ratio decreased | 15.57 | 9.70 | 6 | 131890 | 59 | 50473169 |
Fluid retention | 15.53 | 9.70 | 201 | 131695 | 50448 | 50422780 |
Gallbladder injury | 15.52 | 9.70 | 18 | 131878 | 1276 | 50471952 |
Anuria | 15.47 | 9.70 | 5 | 131891 | 11239 | 50461989 |
Swelling face | 15.41 | 9.70 | 207 | 131689 | 52388 | 50420840 |
Hypothermia | 15.41 | 9.70 | 6 | 131890 | 12010 | 50461218 |
Asthmatic crisis | 15.25 | 9.70 | 20 | 131876 | 1608 | 50471620 |
Palmar-plantar erythrodysaesthesia syndrome | 15.16 | 9.70 | 18 | 131878 | 20080 | 50453148 |
Cardiac failure | 15.14 | 9.70 | 126 | 131770 | 75914 | 50397314 |
Haemophilus infection | 15.11 | 9.70 | 16 | 131880 | 1025 | 50472203 |
Hypervolaemia | 15.08 | 9.70 | 116 | 131780 | 25383 | 50447845 |
Sinus congestion | 14.89 | 9.70 | 74 | 131822 | 13897 | 50459331 |
Infusion site extravasation | 14.88 | 9.70 | 46 | 131850 | 6930 | 50466298 |
Ear canal erythema | 14.86 | 9.70 | 3 | 131893 | 0 | 50473228 |
Stevens-Johnson syndrome | 14.84 | 9.70 | 21 | 131875 | 21731 | 50451497 |
Limb injury | 14.82 | 9.70 | 97 | 131799 | 20153 | 50453075 |
Growth retardation | 14.64 | 9.70 | 16 | 131880 | 1062 | 50472166 |
Gammopathy | 14.44 | 9.70 | 7 | 131889 | 125 | 50473103 |
Cholecystectomy | 14.30 | 9.70 | 55 | 131841 | 9248 | 50463980 |
Bronchospasm paradoxical | 14.29 | 9.70 | 6 | 131890 | 75 | 50473153 |
Respiratory tract congestion | 14.29 | 9.70 | 74 | 131822 | 14125 | 50459103 |
Injection site inflammation | 14.22 | 9.70 | 28 | 131868 | 3177 | 50470051 |
Acute generalised exanthematous pustulosis | 14.15 | 9.70 | 3 | 131893 | 8935 | 50464293 |
Eosinophilic bronchitis | 14.10 | 9.70 | 11 | 131885 | 472 | 50472756 |
Conjunctivitis allergic | 14.07 | 9.70 | 13 | 131883 | 705 | 50472523 |
Peripheral swelling | 14.03 | 9.70 | 419 | 131477 | 205517 | 50267711 |
Sneezing | 14.00 | 9.70 | 73 | 131823 | 13971 | 50459257 |
Multiple drug therapy | 13.98 | 9.70 | 21 | 131875 | 1916 | 50471312 |
Infusion site bruising | 13.96 | 9.70 | 23 | 131873 | 2272 | 50470956 |
Middle insomnia | 13.92 | 9.70 | 57 | 131839 | 9864 | 50463364 |
Arthralgia | 13.82 | 9.70 | 971 | 130925 | 437731 | 50035497 |
Gluten sensitivity | 13.77 | 9.70 | 11 | 131885 | 489 | 50472739 |
Senile osteoporosis | 13.73 | 9.70 | 8 | 131888 | 210 | 50473018 |
Transplant rejection | 13.71 | 9.70 | 4 | 131892 | 9605 | 50463623 |
Aspirin-exacerbated respiratory disease | 13.70 | 9.70 | 14 | 131882 | 860 | 50472368 |
Lactic acidosis | 13.67 | 9.70 | 43 | 131853 | 33312 | 50439916 |
Dystonia | 13.65 | 9.70 | 7 | 131889 | 11919 | 50461309 |
Anaphylactic reaction | 13.55 | 9.70 | 207 | 131689 | 53848 | 50419380 |
Mite allergy | 13.52 | 9.70 | 11 | 131885 | 502 | 50472726 |
Oedema peripheral | 13.42 | 9.70 | 521 | 131375 | 157440 | 50315788 |
Hepatitis | 13.35 | 9.70 | 133 | 131763 | 31320 | 50441908 |
Thermal burn | 13.33 | 9.70 | 35 | 131861 | 4806 | 50468422 |
Osteoporosis | 13.30 | 9.70 | 177 | 131719 | 44702 | 50428526 |
Drug resistance | 13.29 | 9.70 | 18 | 131878 | 18971 | 50454257 |
Laryngeal pain | 13.28 | 9.70 | 32 | 131864 | 4167 | 50469061 |
Vision blurred | 13.28 | 9.70 | 283 | 131613 | 78364 | 50394864 |
Lemierre syndrome | 13.25 | 9.70 | 6 | 131890 | 91 | 50473137 |
Inappropriate antidiuretic hormone secretion | 13.23 | 9.70 | 9 | 131887 | 13134 | 50460094 |
Bronchial irritation | 13.22 | 9.70 | 4 | 131892 | 17 | 50473211 |
Memory impairment | 13.22 | 9.70 | 285 | 131611 | 79075 | 50394153 |
Exercise tolerance decreased | 13.18 | 9.70 | 35 | 131861 | 4839 | 50468389 |
Abortion spontaneous | 13.13 | 9.70 | 60 | 131836 | 41712 | 50431516 |
Acute myeloid leukaemia | 13.06 | 9.70 | 12 | 131884 | 15062 | 50458166 |
Ear discomfort | 13.05 | 9.70 | 43 | 131853 | 6701 | 50466527 |
Throat tightness | 12.98 | 9.70 | 96 | 131800 | 20751 | 50452477 |
Transferrin saturation decreased | 12.94 | 9.70 | 11 | 131885 | 534 | 50472694 |
Road traffic accident | 12.89 | 9.70 | 108 | 131788 | 24244 | 50448984 |
Insomnia | 12.86 | 9.70 | 568 | 131328 | 174297 | 50298931 |
Respiratory disorder | 12.81 | 9.70 | 131 | 131765 | 31056 | 50442172 |
Anhedonia | 12.80 | 9.70 | 54 | 131842 | 9470 | 50463758 |
Cardiovascular deconditioning | 12.79 | 9.70 | 3 | 131893 | 3 | 50473225 |
Fracture | 12.78 | 9.70 | 15 | 131881 | 16818 | 50456410 |
Wolff-Parkinson-White syndrome | 12.69 | 9.70 | 6 | 131890 | 101 | 50473127 |
Epilepsy | 12.66 | 9.70 | 23 | 131873 | 21544 | 50451684 |
Septic shock | 12.66 | 9.70 | 92 | 131804 | 57083 | 50416145 |
Tooth infection | 12.48 | 9.70 | 71 | 131825 | 14041 | 50459187 |
Body temperature increased | 12.43 | 9.70 | 41 | 131855 | 31300 | 50441928 |
Magnetic resonance imaging thoracic abnormal | 12.38 | 9.70 | 4 | 131892 | 22 | 50473206 |
Vitamin D decreased | 12.35 | 9.70 | 49 | 131847 | 8357 | 50464871 |
Rhabdomyolysis | 12.30 | 9.70 | 56 | 131840 | 38971 | 50434257 |
Periarthritis | 12.29 | 9.70 | 20 | 131876 | 1955 | 50471273 |
Neck pain | 12.24 | 9.70 | 213 | 131683 | 56854 | 50416374 |
Symptom recurrence | 12.23 | 9.70 | 12 | 131884 | 702 | 50472526 |
Respiration abnormal | 12.17 | 9.70 | 35 | 131861 | 5067 | 50468161 |
Hirsutism | 12.11 | 9.70 | 14 | 131882 | 989 | 50472239 |
Treatment noncompliance | 12.08 | 9.70 | 126 | 131770 | 30024 | 50443204 |
Fracture pain | 12.07 | 9.70 | 9 | 131887 | 361 | 50472867 |
Parkinsonism | 12.05 | 9.70 | 4 | 131892 | 8843 | 50464385 |
Atypical fracture | 12.04 | 9.70 | 11 | 131885 | 588 | 50472640 |
Inflammation | 11.93 | 9.70 | 93 | 131803 | 56819 | 50416409 |
Metastases to lung | 11.84 | 9.70 | 7 | 131889 | 11013 | 50462215 |
Heart rate increased | 11.79 | 9.70 | 274 | 131622 | 76976 | 50396252 |
Stress fracture | 11.70 | 9.70 | 42 | 131854 | 6833 | 50466395 |
Neoplasm progression | 11.66 | 9.70 | 38 | 131858 | 29119 | 50444109 |
Dermatitis contact | 11.60 | 9.70 | 49 | 131847 | 8597 | 50464631 |
Pituitary-dependent Cushing's syndrome | 11.58 | 9.70 | 3 | 131893 | 6 | 50473222 |
Neck injury | 11.53 | 9.70 | 18 | 131878 | 1699 | 50471529 |
Glucocorticoids increased | 11.50 | 9.70 | 6 | 131890 | 126 | 50473102 |
Sedation | 11.49 | 9.70 | 41 | 131855 | 30569 | 50442659 |
Renal failure | 11.49 | 9.70 | 202 | 131694 | 106431 | 50366797 |
Rales | 11.46 | 9.70 | 54 | 131842 | 9924 | 50463304 |
Ulcer | 11.46 | 9.70 | 22 | 131874 | 20178 | 50453050 |
Musculoskeletal chest pain | 11.44 | 9.70 | 85 | 131811 | 18401 | 50454827 |
Aplastic anaemia | 11.38 | 9.70 | 3 | 131893 | 7700 | 50465528 |
Increased bronchial secretion | 11.37 | 9.70 | 17 | 131879 | 1545 | 50471683 |
Subarachnoid haemorrhage | 11.36 | 9.70 | 7 | 131889 | 10769 | 50462459 |
Alanine aminotransferase increased | 11.33 | 9.70 | 162 | 131734 | 88197 | 50385031 |
Obstruction | 11.32 | 9.70 | 20 | 131876 | 2091 | 50471137 |
Spirometry abnormal | 11.30 | 9.70 | 7 | 131889 | 206 | 50473022 |
Osteonecrosis of jaw | 11.28 | 9.70 | 45 | 131851 | 32481 | 50440747 |
Pulmonary arterial hypertension | 11.23 | 9.70 | 91 | 131805 | 20228 | 50453000 |
Impaired quality of life | 11.17 | 9.70 | 38 | 131858 | 6018 | 50467210 |
Pharyngitis streptococcal | 11.11 | 9.70 | 49 | 131847 | 8759 | 50464469 |
Expired product administered | 11.03 | 9.70 | 35 | 131861 | 5347 | 50467881 |
Muscle rigidity | 10.91 | 9.70 | 6 | 131890 | 9823 | 50463405 |
Myalgia | 10.78 | 9.70 | 411 | 131485 | 123908 | 50349320 |
Weight increased | 10.78 | 9.70 | 636 | 131260 | 201255 | 50271973 |
Immune thrombocytopenia | 10.77 | 9.70 | 5 | 131891 | 9012 | 50464216 |
Tracheobronchitis bacterial | 10.72 | 9.70 | 3 | 131893 | 9 | 50473219 |
Vena cava embolism | 10.72 | 9.70 | 3 | 131893 | 9 | 50473219 |
Oliguria | 10.70 | 9.70 | 4 | 131892 | 8212 | 50465016 |
Brain natriuretic peptide | 10.69 | 9.70 | 4 | 131892 | 36 | 50473192 |
Respiratory tract irritation | 10.69 | 9.70 | 9 | 131887 | 431 | 50472797 |
Ill-defined disorder | 10.68 | 9.70 | 91 | 131805 | 54563 | 50418665 |
Hypothalamic pituitary adrenal axis suppression | 10.67 | 9.70 | 6 | 131890 | 147 | 50473081 |
Extrapyramidal disorder | 10.64 | 9.70 | 9 | 131887 | 11761 | 50461467 |
Diabetic ketoacidosis | 10.55 | 9.70 | 19 | 131877 | 17853 | 50455375 |
Vulvovaginal discomfort | 10.51 | 9.70 | 19 | 131877 | 2022 | 50471206 |
Aspergilloma | 10.49 | 9.70 | 6 | 131890 | 152 | 50473076 |
Rash maculo-papular | 10.46 | 9.70 | 35 | 131861 | 26606 | 50446622 |
Metastases to liver | 10.46 | 9.70 | 23 | 131873 | 20081 | 50453147 |
Cystitis interstitial | 10.45 | 9.70 | 15 | 131881 | 1314 | 50471914 |
Knee arthroplasty | 10.39 | 9.70 | 53 | 131843 | 35793 | 50437435 |
Proteinuria | 10.38 | 9.70 | 17 | 131879 | 16580 | 50456648 |
Corneal abrasion | 10.35 | 9.70 | 12 | 131884 | 850 | 50472378 |
Haemodynamic instability | 10.30 | 9.70 | 4 | 131892 | 8020 | 50465208 |
Ischaemic stroke | 10.29 | 9.70 | 16 | 131880 | 15932 | 50457296 |
Stomatitis | 10.29 | 9.70 | 194 | 131702 | 101150 | 50372078 |
Laryngitis | 10.28 | 9.70 | 56 | 131840 | 10900 | 50462328 |
Cytopenia | 10.27 | 9.70 | 5 | 131891 | 8770 | 50464458 |
Vocal cord atrophy | 10.27 | 9.70 | 3 | 131893 | 11 | 50473217 |
Selective IgA immunodeficiency | 10.27 | 9.70 | 3 | 131893 | 11 | 50473217 |
Myocardial infarction | 10.18 | 9.70 | 304 | 131592 | 88723 | 50384505 |
Drug level increased | 10.07 | 9.70 | 22 | 131874 | 19246 | 50453982 |
Food allergy | 10.06 | 9.70 | 45 | 131851 | 8092 | 50465136 |
Ageusia | 10.06 | 9.70 | 58 | 131838 | 11525 | 50461703 |
Hilar lymphadenopathy | 10.02 | 9.70 | 13 | 131883 | 1034 | 50472194 |
Aspartate aminotransferase increased | 10.00 | 9.70 | 143 | 131753 | 77855 | 50395373 |
Psoriasis | 10.00 | 9.70 | 243 | 131653 | 68757 | 50404471 |
Distal intestinal obstruction syndrome | 9.99 | 9.70 | 8 | 131888 | 357 | 50472871 |
Coronary artery disease | 9.99 | 9.70 | 120 | 131776 | 29606 | 50443622 |
Foot deformity | 9.98 | 9.70 | 22 | 131874 | 19188 | 50454040 |
Product taste abnormal | 9.96 | 9.70 | 17 | 131879 | 1728 | 50471500 |
Frostbite | 9.87 | 9.70 | 3 | 131893 | 13 | 50473215 |
Cellulitis | 9.86 | 9.70 | 248 | 131648 | 70550 | 50402678 |
Paraesthesia oral | 9.85 | 9.70 | 60 | 131836 | 12161 | 50461067 |
Haemolytic anaemia | 9.85 | 9.70 | 6 | 131890 | 9286 | 50463942 |
Ascites | 9.85 | 9.70 | 54 | 131842 | 35807 | 50437421 |
Pharyngeal abscess | 9.79 | 9.70 | 7 | 131889 | 263 | 50472965 |
Gastroenteritis viral | 9.77 | 9.70 | 83 | 131813 | 18703 | 50454525 |
Atrial flutter | 9.76 | 9.70 | 47 | 131849 | 8716 | 50464512 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 591.94 | 10.55 | 521 | 61252 | 33328 | 29479426 |
Wheezing | 187.28 | 10.55 | 285 | 61488 | 32955 | 29479799 |
Toxicity to various agents | 184.98 | 10.55 | 66 | 61707 | 173595 | 29339159 |
Sinusitis | 177.47 | 10.55 | 283 | 61490 | 34067 | 29478687 |
Infective pulmonary exacerbation of cystic fibrosis | 175.35 | 10.55 | 127 | 61646 | 6109 | 29506645 |
Eosinophilic granulomatosis with polyangiitis | 159.11 | 10.55 | 71 | 61702 | 1315 | 29511439 |
Cough | 159.10 | 10.55 | 603 | 61170 | 126124 | 29386630 |
Dyspnoea | 155.66 | 10.55 | 1189 | 60584 | 325543 | 29187211 |
Adrenal suppression | 130.13 | 10.55 | 47 | 61726 | 485 | 29512269 |
Productive cough | 120.12 | 10.55 | 226 | 61547 | 31033 | 29481721 |
Completed suicide | 109.24 | 10.55 | 27 | 61746 | 90219 | 29422535 |
Product dose omission issue | 86.17 | 10.55 | 414 | 61359 | 95969 | 29416785 |
Nasal congestion | 82.03 | 10.55 | 144 | 61629 | 18735 | 29494019 |
Acute kidney injury | 79.52 | 10.55 | 286 | 61487 | 264981 | 29247773 |
Bronchitis | 76.82 | 10.55 | 209 | 61564 | 36659 | 29476095 |
Product quality issue | 73.99 | 10.55 | 125 | 61648 | 15770 | 29496984 |
Pneumonia | 73.63 | 10.55 | 1004 | 60769 | 319168 | 29193586 |
Chronic obstructive pulmonary disease | 73.50 | 10.55 | 220 | 61553 | 40735 | 29472019 |
Cystic fibrosis | 72.98 | 10.55 | 43 | 61730 | 1449 | 29511305 |
Nasal polyps | 71.20 | 10.55 | 45 | 61728 | 1724 | 29511030 |
Thrombocytopenia | 58.61 | 10.55 | 121 | 61652 | 134702 | 29378052 |
Sleep disorder due to a general medical condition | 56.03 | 10.55 | 49 | 61724 | 3097 | 29509657 |
Hypothalamic pituitary adrenal axis suppression | 55.96 | 10.55 | 18 | 61755 | 126 | 29512628 |
Full blood count abnormal | 55.73 | 10.55 | 107 | 61666 | 14906 | 29497848 |
Malignant neoplasm progression | 52.70 | 10.55 | 46 | 61727 | 73813 | 29438941 |
Product complaint | 49.87 | 10.55 | 59 | 61714 | 5346 | 29507408 |
Obstructive airways disorder | 49.11 | 10.55 | 85 | 61688 | 10931 | 29501823 |
Epidural lipomatosis | 47.08 | 10.55 | 25 | 61748 | 686 | 29512068 |
Cortisol decreased | 46.11 | 10.55 | 26 | 61747 | 805 | 29511949 |
Drug abuse | 45.58 | 10.55 | 60 | 61713 | 79823 | 29432931 |
Upper respiratory tract infection | 45.40 | 10.55 | 143 | 61630 | 27206 | 29485548 |
Sinus disorder | 45.30 | 10.55 | 59 | 61714 | 5896 | 29506858 |
Sputum discoloured | 43.79 | 10.55 | 61 | 61712 | 6502 | 29506252 |
Cushingoid | 43.48 | 10.55 | 38 | 61735 | 2400 | 29510354 |
Victim of child abuse | 43.04 | 10.55 | 25 | 61748 | 820 | 29511934 |
Off label use | 42.82 | 10.55 | 412 | 61361 | 300388 | 29212366 |
Forced expiratory volume decreased | 42.61 | 10.55 | 40 | 61733 | 2773 | 29509981 |
Sputum increased | 42.58 | 10.55 | 34 | 61739 | 1893 | 29510861 |
Chorioretinopathy | 42.47 | 10.55 | 30 | 61743 | 1386 | 29511368 |
Vocal cord dysfunction | 42.22 | 10.55 | 15 | 61758 | 147 | 29512607 |
Anaemia | 42.01 | 10.55 | 247 | 61526 | 200704 | 29312050 |
Eosinophil count | 41.16 | 10.55 | 14 | 61759 | 119 | 29512635 |
Sleep apnoea syndrome | 40.96 | 10.55 | 104 | 61669 | 17495 | 29495259 |
Neutropenia | 40.01 | 10.55 | 141 | 61632 | 131570 | 29381184 |
Interstitial lung disease | 38.74 | 10.55 | 38 | 61735 | 57680 | 29455074 |
Cushing's syndrome | 38.06 | 10.55 | 18 | 61755 | 383 | 29512371 |
Intentional overdose | 37.08 | 10.55 | 17 | 61756 | 38511 | 29474243 |
Gastrooesophageal reflux disease | 37.03 | 10.55 | 147 | 61626 | 31349 | 29481405 |
Foetal malformation | 36.81 | 10.55 | 13 | 61760 | 125 | 29512629 |
Hepatic function abnormal | 36.74 | 10.55 | 18 | 61755 | 39241 | 29473513 |
Fatigue | 36.52 | 10.55 | 892 | 60881 | 315929 | 29196825 |
Multiple organ dysfunction syndrome | 36.42 | 10.55 | 47 | 61726 | 63069 | 29449685 |
Bronchial hyperreactivity | 35.84 | 10.55 | 27 | 61746 | 1379 | 29511375 |
Renal impairment | 35.30 | 10.55 | 73 | 61700 | 81260 | 29431494 |
Renal failure | 34.66 | 10.55 | 129 | 61644 | 118470 | 29394284 |
Influenza | 33.89 | 10.55 | 175 | 61598 | 41706 | 29471048 |
Breath sounds abnormal | 33.87 | 10.55 | 49 | 61724 | 5408 | 29507346 |
Bronchospasm | 33.85 | 10.55 | 67 | 61706 | 9542 | 29503212 |
Chest discomfort | 33.71 | 10.55 | 187 | 61586 | 45796 | 29466958 |
Chronic sinusitis | 33.22 | 10.55 | 28 | 61745 | 1683 | 29511071 |
Suffocation feeling | 32.93 | 10.55 | 18 | 61755 | 524 | 29512230 |
Overdose | 32.68 | 10.55 | 74 | 61699 | 79745 | 29433009 |
Rhinorrhoea | 32.54 | 10.55 | 109 | 61664 | 21410 | 29491344 |
Trisomy 18 | 32.37 | 10.55 | 13 | 61760 | 183 | 29512571 |
C-reactive protein increased | 32.26 | 10.55 | 27 | 61746 | 44236 | 29468518 |
Upper-airway cough syndrome | 31.45 | 10.55 | 35 | 61738 | 2968 | 29509786 |
Dyspnoea exertional | 31.29 | 10.55 | 155 | 61618 | 36335 | 29476419 |
Painful respiration | 30.94 | 10.55 | 23 | 61750 | 1151 | 29511603 |
Bone marrow failure | 29.89 | 10.55 | 10 | 61763 | 27439 | 29485315 |
Secondary adrenocortical insufficiency | 29.81 | 10.55 | 22 | 61751 | 1089 | 29511665 |
Dysphonia | 29.71 | 10.55 | 98 | 61675 | 19098 | 29493656 |
Bronchial obstruction | 29.58 | 10.55 | 24 | 61749 | 1367 | 29511387 |
Rhabdomyolysis | 29.52 | 10.55 | 51 | 61722 | 60757 | 29451997 |
Pancytopenia | 29.48 | 10.55 | 83 | 61690 | 83085 | 29429669 |
Chest injury | 28.96 | 10.55 | 24 | 61749 | 1409 | 29511345 |
Walking aid user | 28.32 | 10.55 | 24 | 61749 | 1453 | 29511301 |
Pulmonary function test decreased | 28.23 | 10.55 | 39 | 61734 | 4124 | 29508630 |
Respiratory tract congestion | 28.12 | 10.55 | 44 | 61729 | 5205 | 29507549 |
Coma | 27.61 | 10.55 | 25 | 61748 | 39425 | 29473329 |
Status asthmaticus | 27.38 | 10.55 | 13 | 61760 | 279 | 29512475 |
Septic shock | 27.27 | 10.55 | 56 | 61717 | 62504 | 29450250 |
Rhinitis | 26.92 | 10.55 | 41 | 61732 | 4737 | 29508017 |
Blood immunoglobulin E increased | 26.31 | 10.55 | 26 | 61747 | 1921 | 29510833 |
Adrenal insufficiency | 26.19 | 10.55 | 66 | 61707 | 11048 | 29501706 |
Cytomegalovirus infection | 26.09 | 10.55 | 8 | 61765 | 23207 | 29489547 |
Hyperkalaemia | 25.88 | 10.55 | 56 | 61717 | 61336 | 29451418 |
General physical health deterioration | 25.61 | 10.55 | 119 | 61654 | 102738 | 29410016 |
Ear infection | 25.60 | 10.55 | 54 | 61719 | 8046 | 29504708 |
Dyspnoea paroxysmal nocturnal | 25.41 | 10.55 | 22 | 61751 | 1372 | 29511382 |
Metabolic acidosis | 25.03 | 10.55 | 25 | 61748 | 37637 | 29475117 |
Skin striae | 24.50 | 10.55 | 14 | 61759 | 445 | 29512309 |
Leukopenia | 24.41 | 10.55 | 49 | 61724 | 55154 | 29457600 |
Lung hernia | 24.28 | 10.55 | 8 | 61765 | 61 | 29512693 |
Growth retardation | 24.27 | 10.55 | 23 | 61750 | 1613 | 29511141 |
Rhinalgia | 24.14 | 10.55 | 13 | 61760 | 367 | 29512387 |
Treatment failure | 24.00 | 10.55 | 25 | 61748 | 36914 | 29475840 |
Nasal inflammation | 23.70 | 10.55 | 11 | 61762 | 224 | 29512530 |
Neuroleptic malignant syndrome | 23.48 | 10.55 | 3 | 61770 | 16145 | 29496609 |
Dermatitis atopic | 23.48 | 10.55 | 26 | 61747 | 2193 | 29510561 |
Bronchiectasis | 23.30 | 10.55 | 46 | 61727 | 6539 | 29506215 |
Nasopharyngitis | 23.23 | 10.55 | 208 | 61565 | 59457 | 29453297 |
Drug resistance | 23.19 | 10.55 | 8 | 61765 | 21532 | 29491222 |
Foetal exposure during pregnancy | 23.06 | 10.55 | 22 | 61751 | 33845 | 29478909 |
Hypertrophic osteoarthropathy | 22.74 | 10.55 | 8 | 61765 | 76 | 29512678 |
Sinus congestion | 22.43 | 10.55 | 37 | 61736 | 4575 | 29508179 |
Febrile neutropenia | 22.33 | 10.55 | 140 | 61633 | 112100 | 29400654 |
Cerebral infarction | 22.06 | 10.55 | 12 | 61761 | 24663 | 29488091 |
Eosinophil count increased | 21.99 | 10.55 | 48 | 61725 | 7321 | 29505433 |
Vision blurred | 21.66 | 10.55 | 151 | 61622 | 40025 | 29472729 |
Throat irritation | 21.58 | 10.55 | 53 | 61720 | 8732 | 29504022 |
Headache | 21.50 | 10.55 | 495 | 61278 | 173512 | 29339242 |
Central obesity | 21.32 | 10.55 | 13 | 61760 | 467 | 29512287 |
Anxiety | 21.24 | 10.55 | 272 | 61501 | 85093 | 29427661 |
Carcinoid tumour of the gastrointestinal tract | 21.17 | 10.55 | 7 | 61766 | 54 | 29512700 |
Blood creatinine increased | 20.86 | 10.55 | 99 | 61674 | 85003 | 29427751 |
Depressed level of consciousness | 20.80 | 10.55 | 28 | 61745 | 36914 | 29475840 |
Peripheral swelling | 20.76 | 10.55 | 214 | 61559 | 63525 | 29449229 |
Bradycardia | 20.75 | 10.55 | 69 | 61704 | 65560 | 29447194 |
Blood creatine phosphokinase increased | 20.73 | 10.55 | 33 | 61740 | 40611 | 29472143 |
Plethoric face | 20.69 | 10.55 | 4 | 61769 | 0 | 29512754 |
Drug reaction with eosinophilia and systemic symptoms | 20.48 | 10.55 | 17 | 61756 | 27975 | 29484779 |
Hypersomnia | 20.45 | 10.55 | 59 | 61714 | 10695 | 29502059 |
Forced expiratory flow decreased | 20.45 | 10.55 | 9 | 61764 | 161 | 29512593 |
Hospitalisation | 20.36 | 10.55 | 165 | 61608 | 45823 | 29466931 |
Cholestasis | 20.13 | 10.55 | 12 | 61761 | 23450 | 29489304 |
Delirium | 20.09 | 10.55 | 32 | 61741 | 39365 | 29473389 |
Seasonal allergy | 19.72 | 10.55 | 37 | 61736 | 5065 | 29507689 |
Therapeutic product effect incomplete | 19.61 | 10.55 | 145 | 61628 | 39160 | 29473594 |
Hot flush | 19.61 | 10.55 | 72 | 61701 | 14798 | 29497956 |
Oral candidiasis | 19.60 | 10.55 | 58 | 61715 | 10664 | 29502090 |
Atopy | 19.40 | 10.55 | 8 | 61765 | 121 | 29512633 |
Premature baby | 19.33 | 10.55 | 6 | 61767 | 17274 | 29495480 |
Hypoacusis | 19.16 | 10.55 | 70 | 61703 | 14353 | 29498401 |
Loss of personal independence in daily activities | 19.00 | 10.55 | 104 | 61669 | 25336 | 29487418 |
Anosmia | 18.81 | 10.55 | 22 | 61751 | 1969 | 29510785 |
Altered state of consciousness | 18.79 | 10.55 | 9 | 61764 | 19880 | 29492874 |
Mucosal inflammation | 18.77 | 10.55 | 23 | 61750 | 31572 | 29481182 |
Rash maculo-papular | 18.72 | 10.55 | 14 | 61759 | 24275 | 29488479 |
Drug interaction | 18.65 | 10.55 | 295 | 61478 | 197090 | 29315664 |
Antineutrophil cytoplasmic antibody positive | 18.45 | 10.55 | 13 | 61760 | 598 | 29512156 |
Eosinophilic oesophagitis | 18.27 | 10.55 | 9 | 61764 | 210 | 29512544 |
Nasal oedema | 18.27 | 10.55 | 10 | 61763 | 292 | 29512462 |
Cystic fibrosis respiratory infection suppression | 18.23 | 10.55 | 9 | 61764 | 211 | 29512543 |
Neutrophil count decreased | 18.14 | 10.55 | 40 | 61733 | 43527 | 29469227 |
Stridor | 18.12 | 10.55 | 23 | 61750 | 2240 | 29510514 |
Serotonin syndrome | 18.01 | 10.55 | 7 | 61766 | 17505 | 29495249 |
Eye disorder | 17.92 | 10.55 | 46 | 61727 | 7788 | 29504966 |
Nasal discomfort | 17.91 | 10.55 | 17 | 61756 | 1195 | 29511559 |
Nervous system neoplasm | 17.88 | 10.55 | 8 | 61765 | 149 | 29512605 |
Tendon calcification | 17.74 | 10.55 | 6 | 61767 | 50 | 29512704 |
Juvenile idiopathic arthritis | 17.70 | 10.55 | 18 | 61755 | 1376 | 29511378 |
Contraindicated product administered | 17.66 | 10.55 | 8 | 61765 | 18258 | 29494496 |
Stress | 17.51 | 10.55 | 90 | 61683 | 21400 | 29491354 |
Illness | 17.18 | 10.55 | 41 | 61732 | 6633 | 29506121 |
Lacrimation increased | 17.02 | 10.55 | 42 | 61731 | 6938 | 29505816 |
Eosinophilic bronchitis | 16.92 | 10.55 | 8 | 61765 | 170 | 29512584 |
Middle insomnia | 16.83 | 10.55 | 37 | 61736 | 5671 | 29507083 |
Panic reaction | 16.74 | 10.55 | 17 | 61756 | 1298 | 29511456 |
Hepatocellular injury | 16.69 | 10.55 | 12 | 61761 | 21231 | 29491523 |
Agranulocytosis | 16.63 | 10.55 | 11 | 61762 | 20329 | 29492425 |
Rhinitis allergic | 16.54 | 10.55 | 24 | 61749 | 2656 | 29510098 |
Feeling cold | 16.12 | 10.55 | 49 | 61724 | 9142 | 29503612 |
Cortisol abnormal | 15.93 | 10.55 | 5 | 61768 | 32 | 29512722 |
Snoring | 15.84 | 10.55 | 24 | 61749 | 2760 | 29509994 |
Increased viscosity of bronchial secretion | 15.74 | 10.55 | 8 | 61765 | 200 | 29512554 |
Lower respiratory tract infection | 15.72 | 10.55 | 102 | 61671 | 26400 | 29486354 |
Abnormal behaviour | 15.59 | 10.55 | 92 | 61681 | 23035 | 29489719 |
Anger | 15.44 | 10.55 | 54 | 61719 | 10836 | 29501918 |
Migraine | 15.40 | 10.55 | 59 | 61714 | 12371 | 29500383 |
Nasal disorder | 15.37 | 10.55 | 17 | 61756 | 1432 | 29511322 |
Injection site pruritus | 15.13 | 10.55 | 36 | 61737 | 5813 | 29506941 |
Nasal obstruction | 14.95 | 10.55 | 11 | 61762 | 542 | 29512212 |
Central nervous system mass | 14.78 | 10.55 | 6 | 61767 | 87 | 29512667 |
Personality change | 14.75 | 10.55 | 31 | 61742 | 4607 | 29508147 |
Cerebral haemorrhage | 14.67 | 10.55 | 27 | 61746 | 31399 | 29481355 |
Dry skin | 14.62 | 10.55 | 91 | 61682 | 23216 | 29489538 |
Toxic epidermal necrolysis | 14.60 | 10.55 | 10 | 61763 | 18143 | 29494611 |
Sepsis | 14.57 | 10.55 | 210 | 61563 | 142472 | 29370282 |
Kidney infection | 14.54 | 10.55 | 31 | 61742 | 4652 | 29508102 |
Melaena | 14.36 | 10.55 | 27 | 61746 | 31149 | 29481605 |
Gamma-glutamyltransferase increased | 14.32 | 10.55 | 21 | 61752 | 26716 | 29486038 |
Choking | 14.26 | 10.55 | 30 | 61743 | 4461 | 29508293 |
Neck pain | 14.25 | 10.55 | 85 | 61688 | 21362 | 29491392 |
Back pain | 14.21 | 10.55 | 296 | 61477 | 101988 | 29410766 |
Wall motion score index abnormal | 14.19 | 10.55 | 6 | 61767 | 97 | 29512657 |
Insulin autoimmune syndrome | 13.98 | 10.55 | 8 | 61765 | 255 | 29512499 |
Oesophageal candidiasis | 13.89 | 10.55 | 27 | 61746 | 3794 | 29508960 |
Drug intolerance | 13.87 | 10.55 | 53 | 61720 | 48326 | 29464428 |
Platelet count decreased | 13.72 | 10.55 | 146 | 61627 | 104526 | 29408228 |
Blood lactate dehydrogenase increased | 13.64 | 10.55 | 12 | 61761 | 19197 | 29493557 |
Disseminated intravascular coagulation | 13.58 | 10.55 | 13 | 61760 | 19967 | 29492787 |
Cardiac arrest | 13.52 | 10.55 | 114 | 61659 | 85477 | 29427277 |
Oropharyngeal pain | 13.46 | 10.55 | 106 | 61667 | 29179 | 29483575 |
Shock | 13.33 | 10.55 | 15 | 61758 | 21389 | 29491365 |
Oxygen saturation decreased | 13.28 | 10.55 | 148 | 61625 | 44789 | 29467965 |
Blood urea increased | 13.26 | 10.55 | 24 | 61749 | 28088 | 29484666 |
Multiple allergies | 13.23 | 10.55 | 19 | 61754 | 2083 | 29510671 |
Haemophilus infection | 13.23 | 10.55 | 13 | 61760 | 954 | 29511800 |
Poor quality device used | 13.08 | 10.55 | 12 | 61761 | 808 | 29511946 |
Hepatic failure | 13.06 | 10.55 | 29 | 61744 | 31483 | 29481271 |
Rheumatoid arthritis | 12.99 | 10.55 | 30 | 61743 | 32122 | 29480632 |
Atelectasis | 12.92 | 10.55 | 65 | 61708 | 15327 | 29497427 |
Tracheal disorder | 12.89 | 10.55 | 6 | 61767 | 123 | 29512631 |
Hepatotoxicity | 12.89 | 10.55 | 11 | 61762 | 17856 | 29494898 |
Smoke sensitivity | 12.80 | 10.55 | 6 | 61767 | 125 | 29512629 |
Cardiac failure | 12.79 | 10.55 | 105 | 61668 | 79182 | 29433572 |
Inhalation therapy | 12.69 | 10.55 | 4 | 61769 | 26 | 29512728 |
Haemoptysis | 12.66 | 10.55 | 108 | 61665 | 30442 | 29482312 |
Drug-induced liver injury | 12.61 | 10.55 | 16 | 61757 | 21639 | 29491115 |
Lipohypertrophy | 12.58 | 10.55 | 7 | 61766 | 211 | 29512543 |
Increased bronchial secretion | 12.55 | 10.55 | 16 | 61757 | 1565 | 29511189 |
Night sweats | 12.49 | 10.55 | 63 | 61710 | 14869 | 29497885 |
Allergic sinusitis | 12.47 | 10.55 | 5 | 61768 | 70 | 29512684 |
Throat clearing | 12.44 | 10.55 | 7 | 61766 | 216 | 29512538 |
Respiratory disorder | 12.39 | 10.55 | 69 | 61704 | 16914 | 29495840 |
Eye swelling | 12.34 | 10.55 | 43 | 61730 | 8614 | 29504140 |
Sneezing | 12.33 | 10.55 | 28 | 61745 | 4386 | 29508368 |
Cardio-respiratory arrest | 12.31 | 10.55 | 59 | 61714 | 50542 | 29462212 |
Hyperbilirubinaemia | 12.31 | 10.55 | 8 | 61765 | 14926 | 29497828 |
Hypomagnesaemia | 12.30 | 10.55 | 11 | 61762 | 17457 | 29495297 |
Pre-existing condition improved | 12.22 | 10.55 | 19 | 61754 | 2234 | 29510520 |
Child abuse | 12.21 | 10.55 | 7 | 61766 | 224 | 29512530 |
Blood testosterone decreased | 12.19 | 10.55 | 26 | 61747 | 3904 | 29508850 |
Airway remodelling | 12.14 | 10.55 | 6 | 61767 | 141 | 29512613 |
Poisoning | 12.06 | 10.55 | 3 | 61770 | 9990 | 29502764 |
Hypertrichosis | 12.04 | 10.55 | 8 | 61765 | 334 | 29512420 |
Wrong technique in device usage process | 11.98 | 10.55 | 13 | 61760 | 1072 | 29511682 |
Hypoaesthesia | 11.90 | 10.55 | 167 | 61606 | 53300 | 29459454 |
Contusion | 11.89 | 10.55 | 108 | 61665 | 30987 | 29481767 |
Urticaria | 11.87 | 10.55 | 170 | 61603 | 54490 | 29458264 |
Synovitis | 11.80 | 10.55 | 4 | 61769 | 10886 | 29501868 |
Meralgia paraesthetica | 11.70 | 10.55 | 6 | 61767 | 153 | 29512601 |
Extrapyramidal disorder | 11.70 | 10.55 | 4 | 61769 | 10827 | 29501927 |
Hemiparesis | 11.62 | 10.55 | 8 | 61765 | 14478 | 29498276 |
Otitis media | 11.57 | 10.55 | 20 | 61753 | 2569 | 29510185 |
Nephropathy toxic | 11.57 | 10.55 | 4 | 61769 | 10752 | 29502002 |
Increased tendency to bruise | 11.55 | 10.55 | 24 | 61749 | 3538 | 29509216 |
Graft versus host disease | 11.41 | 10.55 | 3 | 61770 | 9625 | 29503129 |
IPEX syndrome | 11.38 | 10.55 | 3 | 61770 | 9 | 29512745 |
Deformity thorax | 11.28 | 10.55 | 4 | 61769 | 39 | 29512715 |
Penile erythema | 11.25 | 10.55 | 6 | 61767 | 166 | 29512588 |
Hyposmia | 11.19 | 10.55 | 6 | 61767 | 168 | 29512586 |
Blood bilirubin increased | 11.15 | 10.55 | 35 | 61738 | 33858 | 29478896 |
Bronchopulmonary aspergillosis allergic | 11.15 | 10.55 | 9 | 61764 | 509 | 29512245 |
Increased upper airway secretion | 11.12 | 10.55 | 15 | 61758 | 1551 | 29511203 |
Respiratory syncytial virus infection | 11.11 | 10.55 | 24 | 61749 | 3635 | 29509119 |
Infusion site pruritus | 11.10 | 10.55 | 9 | 61764 | 512 | 29512242 |
Respiratory tract infection | 11.03 | 10.55 | 63 | 61710 | 15588 | 29497166 |
Alanine aminotransferase increased | 10.97 | 10.55 | 95 | 61678 | 70849 | 29441905 |
Administration site swelling | 10.87 | 10.55 | 6 | 61767 | 178 | 29512576 |
Abdominal discomfort | 10.81 | 10.55 | 150 | 61623 | 47753 | 29465001 |
Cystitis | 10.81 | 10.55 | 40 | 61733 | 8252 | 29504502 |
Weight decreased | 10.80 | 10.55 | 401 | 61372 | 150504 | 29362250 |
Hand-foot-and-mouth disease | 10.77 | 10.55 | 4 | 61769 | 45 | 29512709 |
Muscle spasms | 10.61 | 10.55 | 193 | 61580 | 64889 | 29447865 |
Suicidal ideation | 10.56 | 10.55 | 115 | 61658 | 34601 | 29478153 |
Pancreatic failure | 10.56 | 10.55 | 10 | 61763 | 701 | 29512053 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 950.83 | 9.66 | 1138 | 148555 | 94087 | 64254952 |
Toxicity to various agents | 422.57 | 9.66 | 158 | 149535 | 363355 | 63985684 |
Completed suicide | 417.72 | 9.66 | 26 | 149667 | 224388 | 64124651 |
Wheezing | 399.97 | 9.66 | 691 | 149002 | 79888 | 64269151 |
Infective pulmonary exacerbation of cystic fibrosis | 377.82 | 9.66 | 271 | 149422 | 11525 | 64337514 |
Cough | 323.51 | 9.66 | 1473 | 148220 | 300675 | 64048364 |
Dyspnoea | 313.36 | 9.66 | 2782 | 146911 | 715892 | 63633147 |
Eosinophilic granulomatosis with polyangiitis | 286.45 | 9.66 | 138 | 149555 | 2744 | 64346295 |
Chest discomfort | 215.77 | 9.66 | 676 | 149017 | 115430 | 64233609 |
Bronchitis | 196.43 | 9.66 | 627 | 149066 | 108116 | 64240923 |
Sinusitis | 194.37 | 9.66 | 761 | 148932 | 145167 | 64203872 |
Product quality issue | 176.67 | 9.66 | 277 | 149416 | 29522 | 64319517 |
Synovitis | 171.48 | 9.66 | 16 | 149677 | 99074 | 64249965 |
Productive cough | 171.36 | 9.66 | 463 | 149230 | 72740 | 64276299 |
Chronic obstructive pulmonary disease | 166.94 | 9.66 | 450 | 149243 | 70598 | 64278441 |
Contraindicated product administered | 146.56 | 9.66 | 35 | 149658 | 107794 | 64241245 |
Off label use | 145.91 | 9.66 | 867 | 148826 | 631939 | 63717100 |
Obstructive airways disorder | 145.11 | 9.66 | 221 | 149472 | 22964 | 64326075 |
Acute kidney injury | 141.67 | 9.66 | 550 | 149143 | 448690 | 63900349 |
Nasal congestion | 139.28 | 9.66 | 377 | 149316 | 59281 | 64289758 |
Adrenal suppression | 136.31 | 9.66 | 65 | 149628 | 1262 | 64347777 |
Drug abuse | 135.36 | 9.66 | 69 | 149624 | 132305 | 64216734 |
Pneumonia | 135.03 | 9.66 | 1931 | 147762 | 557645 | 63791394 |
Neutropenia | 134.36 | 9.66 | 218 | 149475 | 239406 | 64109633 |
Product dose omission issue | 133.09 | 9.66 | 840 | 148853 | 193907 | 64155132 |
Thrombocytopenia | 127.92 | 9.66 | 201 | 149492 | 223600 | 64125439 |
Nasal polyps | 124.59 | 9.66 | 87 | 149606 | 3542 | 64345497 |
Sputum increased | 122.13 | 9.66 | 86 | 149607 | 3549 | 64345490 |
Intentional overdose | 116.84 | 9.66 | 32 | 149661 | 89912 | 64259127 |
Pemphigus | 112.93 | 9.66 | 7 | 149686 | 60694 | 64288345 |
Hand deformity | 108.96 | 9.66 | 10 | 149683 | 62761 | 64286278 |
Pericarditis | 100.79 | 9.66 | 13 | 149680 | 62503 | 64286536 |
Upper respiratory tract infection | 99.60 | 9.66 | 383 | 149310 | 72402 | 64276637 |
Cystic fibrosis | 98.89 | 9.66 | 74 | 149619 | 3360 | 64345679 |
Anxiety | 96.71 | 9.66 | 802 | 148891 | 201847 | 64147192 |
Treatment failure | 94.82 | 9.66 | 79 | 149614 | 116737 | 64232302 |
Sleep apnoea syndrome | 92.32 | 9.66 | 210 | 149483 | 29622 | 64319417 |
Drug intolerance | 91.93 | 9.66 | 186 | 149507 | 187806 | 64161233 |
General physical health deterioration | 91.90 | 9.66 | 212 | 149481 | 204213 | 64144826 |
Malignant neoplasm progression | 90.80 | 9.66 | 77 | 149616 | 112794 | 64236245 |
Systemic lupus erythematosus | 87.86 | 9.66 | 35 | 149658 | 77577 | 64271462 |
Pancytopenia | 84.44 | 9.66 | 126 | 149567 | 143183 | 64205856 |
Full blood count abnormal | 82.85 | 9.66 | 201 | 149492 | 29556 | 64319483 |
Chronic sinusitis | 81.11 | 9.66 | 86 | 149607 | 6206 | 64342833 |
Gastrooesophageal reflux disease | 79.64 | 9.66 | 393 | 149300 | 82750 | 64266289 |
Forced expiratory volume decreased | 78.32 | 9.66 | 88 | 149605 | 6779 | 64342260 |
Product complaint | 76.29 | 9.66 | 115 | 149578 | 11839 | 64337200 |
Febrile neutropenia | 75.48 | 9.66 | 206 | 149487 | 187451 | 64161588 |
Sleep disorder due to a general medical condition | 74.88 | 9.66 | 94 | 149599 | 8140 | 64340899 |
Multiple organ dysfunction syndrome | 74.68 | 9.66 | 75 | 149618 | 101338 | 64247701 |
Overdose | 73.71 | 9.66 | 163 | 149530 | 159403 | 64189636 |
Dyspnoea exertional | 73.12 | 9.66 | 352 | 149341 | 73378 | 64275661 |
Hepatic function abnormal | 72.80 | 9.66 | 29 | 149664 | 64284 | 64284755 |
Sputum discoloured | 71.91 | 9.66 | 140 | 149553 | 17716 | 64331323 |
Dysphonia | 70.06 | 9.66 | 252 | 149441 | 46130 | 64302909 |
Cushing's syndrome | 69.52 | 9.66 | 37 | 149656 | 914 | 64348125 |
Coma | 68.97 | 9.66 | 61 | 149632 | 87554 | 64261485 |
Anaemia | 67.73 | 9.66 | 558 | 149135 | 378122 | 63970917 |
Duodenal ulcer perforation | 64.38 | 9.66 | 4 | 149689 | 34621 | 64314418 |
Joint swelling | 61.91 | 9.66 | 273 | 149420 | 215109 | 64133930 |
Cardio-respiratory arrest | 60.42 | 9.66 | 84 | 149609 | 98309 | 64250730 |
Hepatic enzyme increased | 59.79 | 9.66 | 133 | 149560 | 129810 | 64219229 |
Leukopenia | 59.64 | 9.66 | 89 | 149604 | 101153 | 64247886 |
Mucosal inflammation | 59.07 | 9.66 | 36 | 149657 | 62548 | 64286491 |
Renal impairment | 59.06 | 9.66 | 142 | 149551 | 134875 | 64214164 |
Bronchial neoplasm | 59.02 | 9.66 | 26 | 149667 | 417 | 64348622 |
Bone marrow failure | 58.73 | 9.66 | 19 | 149674 | 47933 | 64301106 |
Hypothalamic pituitary adrenal axis suppression | 58.59 | 9.66 | 23 | 149670 | 271 | 64348768 |
Chest pain | 57.68 | 9.66 | 817 | 148876 | 235163 | 64113876 |
Pulmonary function test decreased | 57.55 | 9.66 | 73 | 149620 | 6388 | 64342651 |
Drug reaction with eosinophilia and systemic symptoms | 57.31 | 9.66 | 27 | 149666 | 54190 | 64294849 |
Respiratory symptom | 56.75 | 9.66 | 51 | 149642 | 3002 | 64346037 |
Metabolic acidosis | 56.33 | 9.66 | 49 | 149644 | 70909 | 64278130 |
Wound | 55.80 | 9.66 | 57 | 149636 | 76420 | 64272619 |
Platelet count decreased | 55.52 | 9.66 | 201 | 149492 | 167510 | 64181529 |
Rhinitis allergic | 54.84 | 9.66 | 80 | 149613 | 7998 | 64341041 |
Therapeutic product effect decreased | 54.78 | 9.66 | 116 | 149577 | 115235 | 64233804 |
Interstitial lung disease | 54.62 | 9.66 | 89 | 149604 | 97643 | 64251396 |
C-reactive protein increased | 54.40 | 9.66 | 85 | 149608 | 94824 | 64254215 |
Drug interaction | 53.73 | 9.66 | 559 | 149134 | 361524 | 63987515 |
Adrenal insufficiency | 53.36 | 9.66 | 143 | 149550 | 22344 | 64326695 |
Breath sounds abnormal | 52.58 | 9.66 | 96 | 149597 | 11573 | 64337466 |
Nasal turbinate hypertrophy | 52.55 | 9.66 | 26 | 149667 | 549 | 64348490 |
Drug ineffective | 52.49 | 9.66 | 1518 | 148175 | 838729 | 63510310 |
Cortisol decreased | 52.48 | 9.66 | 38 | 149655 | 1639 | 64347400 |
Rhinitis | 51.63 | 9.66 | 91 | 149602 | 10674 | 64338365 |
Migraine | 51.54 | 9.66 | 284 | 149409 | 62393 | 64286646 |
Helicobacter infection | 51.04 | 9.66 | 13 | 149680 | 38349 | 64310690 |
Glossodynia | 50.96 | 9.66 | 45 | 149648 | 64651 | 64284388 |
Bronchial obstruction | 50.87 | 9.66 | 43 | 149650 | 2331 | 64346708 |
Headache | 50.81 | 9.66 | 1597 | 148096 | 527870 | 63821169 |
Influenza | 49.89 | 9.66 | 420 | 149273 | 106111 | 64242928 |
Rheumatoid arthritis | 49.81 | 9.66 | 204 | 149489 | 164090 | 64184949 |
Muscle injury | 49.31 | 9.66 | 3 | 149690 | 26434 | 64322605 |
Folliculitis | 49.10 | 9.66 | 6 | 149687 | 30071 | 64318968 |
Rhinorrhoea | 48.82 | 9.66 | 271 | 149422 | 59698 | 64289341 |
Cytomegalovirus infection | 48.74 | 9.66 | 13 | 149680 | 37186 | 64311853 |
Deep vein thrombosis | 48.37 | 9.66 | 413 | 149280 | 104769 | 64244270 |
Eosinophil count increased | 47.78 | 9.66 | 103 | 149590 | 14009 | 64335030 |
Hepatotoxicity | 46.92 | 9.66 | 17 | 149676 | 39945 | 64309094 |
Injury | 44.89 | 9.66 | 252 | 149441 | 55740 | 64293299 |
Emotional distress | 44.74 | 9.66 | 184 | 149509 | 35854 | 64313185 |
Depressed level of consciousness | 44.73 | 9.66 | 75 | 149618 | 81361 | 64267678 |
Hyperkalaemia | 44.50 | 9.66 | 106 | 149587 | 101023 | 64248016 |
Endometrial ablation | 44.45 | 9.66 | 26 | 149667 | 775 | 64348264 |
Gamma-glutamyltransferase increased | 44.27 | 9.66 | 29 | 149664 | 48481 | 64300558 |
Hepatocellular injury | 44.13 | 9.66 | 25 | 149668 | 45210 | 64303829 |
Arthropathy | 44.10 | 9.66 | 139 | 149554 | 120828 | 64228211 |
Salpingo-oophorectomy unilateral | 44.06 | 9.66 | 22 | 149671 | 474 | 64348565 |
Sopor | 43.63 | 9.66 | 8 | 149685 | 29653 | 64319386 |
Maternal exposure during pregnancy | 43.40 | 9.66 | 99 | 149594 | 95785 | 64253254 |
Cushingoid | 42.74 | 9.66 | 69 | 149624 | 7534 | 64341505 |
Rhonchi | 42.29 | 9.66 | 46 | 149647 | 3417 | 64345622 |
Poor quality device used | 42.28 | 9.66 | 36 | 149657 | 1971 | 64347068 |
Infusion related reaction | 41.68 | 9.66 | 218 | 149475 | 164249 | 64184790 |
Sleep disorder due to general medical condition, insomnia type | 41.07 | 9.66 | 6 | 149687 | 26264 | 64322775 |
Depression | 40.99 | 9.66 | 625 | 149068 | 182666 | 64166373 |
Sinusitis fungal | 40.94 | 9.66 | 33 | 149660 | 1673 | 64347366 |
Serotonin syndrome | 40.85 | 9.66 | 20 | 149673 | 39262 | 64309777 |
Toxic epidermal necrolysis | 40.07 | 9.66 | 18 | 149675 | 37148 | 64311891 |
Feeling abnormal | 39.92 | 9.66 | 480 | 149213 | 133122 | 64215917 |
Status asthmaticus | 39.91 | 9.66 | 26 | 149667 | 942 | 64348097 |
Victim of child abuse | 39.90 | 9.66 | 25 | 149668 | 846 | 64348193 |
Epidural lipomatosis | 39.74 | 9.66 | 25 | 149668 | 852 | 64348187 |
Upper-airway cough syndrome | 39.33 | 9.66 | 72 | 149621 | 8698 | 64340341 |
Agranulocytosis | 38.94 | 9.66 | 20 | 149673 | 38209 | 64310830 |
Rhabdomyolysis | 38.90 | 9.66 | 98 | 149595 | 91628 | 64257411 |
Bradycardia | 38.90 | 9.66 | 142 | 149551 | 118077 | 64230962 |
Oropharyngeal pain | 38.80 | 9.66 | 345 | 149348 | 88522 | 64260517 |
Bladder prolapse | 38.34 | 9.66 | 27 | 149666 | 1114 | 64347925 |
Stress | 38.14 | 9.66 | 256 | 149437 | 60278 | 64288761 |
Dermatitis atopic | 38.07 | 9.66 | 46 | 149647 | 3830 | 64345209 |
Septic shock | 37.84 | 9.66 | 122 | 149571 | 105315 | 64243724 |
Cholecystitis chronic | 37.62 | 9.66 | 73 | 149620 | 9214 | 64339825 |
Viral infection | 37.61 | 9.66 | 175 | 149518 | 35965 | 64313074 |
Acute respiratory failure | 37.59 | 9.66 | 221 | 149472 | 49713 | 64299326 |
Eosinophil count | 37.46 | 9.66 | 13 | 149680 | 105 | 64348934 |
Alopecia | 37.45 | 9.66 | 228 | 149465 | 165462 | 64183577 |
Neutrophil count decreased | 37.17 | 9.66 | 77 | 149616 | 77119 | 64271920 |
Nasal discomfort | 37.13 | 9.66 | 48 | 149645 | 4280 | 64344759 |
Emphysema | 37.01 | 9.66 | 93 | 149600 | 13976 | 64335063 |
Altered state of consciousness | 36.90 | 9.66 | 21 | 149672 | 37881 | 64311158 |
Bronchial haemorrhage | 36.68 | 9.66 | 27 | 149666 | 1195 | 64347844 |
Renal failure | 36.53 | 9.66 | 259 | 149434 | 181429 | 64167610 |
Hospitalisation | 36.00 | 9.66 | 298 | 149395 | 74909 | 64274130 |
Myelosuppression | 35.99 | 9.66 | 6 | 149687 | 23824 | 64325215 |
Sinus disorder | 35.65 | 9.66 | 103 | 149590 | 16805 | 64332234 |
Seasonal allergy | 34.57 | 9.66 | 81 | 149612 | 11645 | 64337394 |
Throat irritation | 34.48 | 9.66 | 159 | 149534 | 32552 | 64316487 |
Cholestasis | 34.40 | 9.66 | 32 | 149661 | 44840 | 64304199 |
Posterior reversible encephalopathy syndrome | 34.16 | 9.66 | 6 | 149687 | 22940 | 64326099 |
Acute sinusitis | 33.87 | 9.66 | 45 | 149648 | 4121 | 64344918 |
Toxic skin eruption | 33.65 | 9.66 | 3 | 149690 | 19281 | 64329758 |
Blood immunoglobulin E increased | 33.55 | 9.66 | 43 | 149650 | 3801 | 64345238 |
Hypotension | 33.45 | 9.66 | 653 | 149040 | 380321 | 63968718 |
Blood creatinine increased | 33.28 | 9.66 | 182 | 149511 | 135600 | 64213439 |
Pulmonary embolism | 33.07 | 9.66 | 500 | 149193 | 145856 | 64203183 |
Dermatitis allergic | 32.79 | 9.66 | 93 | 149600 | 15016 | 64334023 |
Middle insomnia | 32.70 | 9.66 | 84 | 149609 | 12793 | 64336246 |
Cardiac failure | 32.68 | 9.66 | 177 | 149516 | 132196 | 64216843 |
Bronchiectasis | 32.62 | 9.66 | 89 | 149604 | 14051 | 64334988 |
Cardiac arrest | 32.26 | 9.66 | 217 | 149476 | 153847 | 64195192 |
Pneumocystis jirovecii pneumonia | 32.03 | 9.66 | 12 | 149681 | 27622 | 64321417 |
Bone erosion | 31.93 | 9.66 | 78 | 149615 | 11517 | 64337522 |
Haemoptysis | 31.85 | 9.66 | 209 | 149484 | 48839 | 64300200 |
Vision blurred | 31.74 | 9.66 | 335 | 149358 | 89981 | 64259058 |
Oesophageal spasm | 31.64 | 9.66 | 34 | 149659 | 2491 | 64346548 |
Palpitations | 31.47 | 9.66 | 376 | 149317 | 104112 | 64244927 |
Electrocardiogram QT prolonged | 31.33 | 9.66 | 88 | 149605 | 79360 | 64269679 |
Prolonged expiration | 31.26 | 9.66 | 21 | 149672 | 802 | 64348237 |
Bronchospasm | 31.22 | 9.66 | 116 | 149577 | 21566 | 64327473 |
Ear infection | 31.05 | 9.66 | 122 | 149571 | 23282 | 64325757 |
Bronchial disorder | 31.04 | 9.66 | 31 | 149662 | 2084 | 64346955 |
Oropharyngeal oedema | 30.88 | 9.66 | 14 | 149679 | 241 | 64348798 |
Hiatus hernia | 30.62 | 9.66 | 109 | 149584 | 19848 | 64329191 |
Dizziness | 30.24 | 9.66 | 1253 | 148440 | 428910 | 63920129 |
Pulmonary mass | 30.11 | 9.66 | 123 | 149570 | 23893 | 64325146 |
Vocal cord dysfunction | 29.57 | 9.66 | 16 | 149677 | 409 | 64348630 |
Urticaria | 29.41 | 9.66 | 493 | 149200 | 146824 | 64202215 |
Extrapyramidal disorder | 29.36 | 9.66 | 5 | 149688 | 19547 | 64329492 |
Death | 29.26 | 9.66 | 875 | 148818 | 481830 | 63867209 |
Rash maculo-papular | 29.01 | 9.66 | 40 | 149653 | 46986 | 64302053 |
Pulmonary hypertension | 28.73 | 9.66 | 185 | 149508 | 42954 | 64306085 |
Neuroleptic malignant syndrome | 28.73 | 9.66 | 11 | 149682 | 24985 | 64324054 |
Eosinophilic bronchitis | 28.58 | 9.66 | 15 | 149678 | 360 | 64348679 |
Eye pruritus | 28.53 | 9.66 | 79 | 149614 | 12580 | 64336459 |
Increased upper airway secretion | 28.53 | 9.66 | 38 | 149655 | 3489 | 64345550 |
Female genital tract fistula | 28.51 | 9.66 | 33 | 149660 | 2625 | 64346414 |
Chorioretinopathy | 28.27 | 9.66 | 30 | 149663 | 2167 | 64346872 |
Drug resistance | 28.15 | 9.66 | 24 | 149669 | 35078 | 64313961 |
Respiratory disorder | 27.94 | 9.66 | 161 | 149532 | 35950 | 64313089 |
Burning sensation | 27.18 | 9.66 | 203 | 149490 | 49461 | 64299578 |
Embolism venous | 27.17 | 9.66 | 37 | 149656 | 3470 | 64345569 |
Neutropenic sepsis | 27.15 | 9.66 | 10 | 149683 | 23262 | 64325777 |
Sinus operation | 27.04 | 9.66 | 26 | 149667 | 1669 | 64347370 |
Growth retardation | 26.92 | 9.66 | 25 | 149668 | 1536 | 64347503 |
Bronchial hyperreactivity | 26.63 | 9.66 | 31 | 149662 | 2481 | 64346558 |
Haemophilus infection | 26.52 | 9.66 | 27 | 149666 | 1858 | 64347181 |
Central obesity | 26.45 | 9.66 | 24 | 149669 | 1431 | 64347608 |
Throat clearing | 26.16 | 9.66 | 23 | 149670 | 1315 | 64347724 |
Liver injury | 25.85 | 9.66 | 19 | 149674 | 29913 | 64319126 |
Concussion | 25.81 | 9.66 | 57 | 149636 | 7881 | 64341158 |
Oxygen saturation decreased | 25.71 | 9.66 | 370 | 149323 | 106806 | 64242233 |
Fatigue | 25.69 | 9.66 | 2043 | 147650 | 746687 | 63602352 |
Suicide attempt | 25.59 | 9.66 | 82 | 149611 | 70925 | 64278114 |
Oesophagogastroduodenoscopy | 25.28 | 9.66 | 11 | 149682 | 171 | 64348868 |
Cerebral infarction | 25.23 | 9.66 | 35 | 149658 | 41009 | 64308030 |
Shock | 25.15 | 9.66 | 31 | 149662 | 38209 | 64310830 |
Secondary adrenocortical insufficiency | 24.96 | 9.66 | 29 | 149664 | 2316 | 64346723 |
Cor pulmonale | 24.91 | 9.66 | 27 | 149666 | 1998 | 64347041 |
Blood lactate dehydrogenase increased | 24.87 | 9.66 | 24 | 149669 | 33054 | 64315985 |
Rectal prolapse | 24.79 | 9.66 | 25 | 149668 | 1701 | 64347338 |
Diverticulum | 24.62 | 9.66 | 77 | 149616 | 13121 | 64335918 |
Cerebral haemorrhage | 24.56 | 9.66 | 51 | 149642 | 51039 | 64298000 |
Respiratory arrest | 24.55 | 9.66 | 54 | 149639 | 52931 | 64296108 |
Jaundice | 24.55 | 9.66 | 47 | 149646 | 48465 | 64300574 |
Hepatic failure | 24.41 | 9.66 | 58 | 149635 | 55336 | 64293703 |
Heart sounds | 24.38 | 9.66 | 16 | 149677 | 587 | 64348452 |
Gastrointestinal disorder | 24.38 | 9.66 | 116 | 149577 | 89593 | 64259446 |
Hypoxia | 24.30 | 9.66 | 312 | 149381 | 87837 | 64261202 |
Infusion site erythema | 24.23 | 9.66 | 51 | 149642 | 6822 | 64342217 |
Nasal mucosal disorder | 24.21 | 9.66 | 13 | 149680 | 327 | 64348712 |
Respiratory tract congestion | 23.70 | 9.66 | 87 | 149606 | 16078 | 64332961 |
Ectropion | 23.45 | 9.66 | 13 | 149680 | 349 | 64348690 |
Sinus congestion | 23.41 | 9.66 | 84 | 149609 | 15355 | 64333684 |
Tumour lysis syndrome | 23.28 | 9.66 | 8 | 149685 | 19432 | 64329607 |
Growth failure | 22.82 | 9.66 | 11 | 149682 | 219 | 64348820 |
Product use in unapproved indication | 22.49 | 9.66 | 282 | 149411 | 176336 | 64172703 |
Chest injury | 22.48 | 9.66 | 28 | 149665 | 2405 | 64346634 |
Confusional state | 22.47 | 9.66 | 449 | 149244 | 260695 | 64088344 |
Hypothermia | 22.39 | 9.66 | 9 | 149684 | 19847 | 64329192 |
Impaired healing | 22.38 | 9.66 | 69 | 149624 | 60404 | 64288635 |
Feeling cold | 22.00 | 9.66 | 111 | 149582 | 23567 | 64325472 |
Neck pain | 21.97 | 9.66 | 229 | 149464 | 61304 | 64287735 |
Granuloma | 21.94 | 9.66 | 48 | 149645 | 6593 | 64342446 |
Cystic fibrosis respiratory infection suppression | 21.91 | 9.66 | 13 | 149680 | 398 | 64348641 |
Hypervolaemia | 21.82 | 9.66 | 158 | 149535 | 38127 | 64310912 |
Oesophageal pain | 21.69 | 9.66 | 32 | 149661 | 3231 | 64345808 |
Thrombotic microangiopathy | 21.48 | 9.66 | 6 | 149687 | 16649 | 64332390 |
Biliary dyskinesia | 21.44 | 9.66 | 27 | 149666 | 2345 | 64346694 |
Eczema | 21.38 | 9.66 | 130 | 149563 | 29590 | 64319449 |
Lactic acidosis | 21.38 | 9.66 | 72 | 149621 | 61338 | 64287701 |
Nephropathy toxic | 21.34 | 9.66 | 7 | 149686 | 17507 | 64331532 |
Aphonia | 21.33 | 9.66 | 56 | 149637 | 8641 | 64340398 |
Inhalation therapy | 21.16 | 9.66 | 7 | 149686 | 48 | 64348991 |
Suffocation feeling | 21.16 | 9.66 | 22 | 149671 | 1552 | 64347487 |
Drug-induced liver injury | 20.90 | 9.66 | 50 | 149643 | 47593 | 64301446 |
Weight increased | 20.76 | 9.66 | 645 | 149048 | 212703 | 64136336 |
Anosmia | 20.74 | 9.66 | 37 | 149656 | 4380 | 64344659 |
Anuria | 20.73 | 9.66 | 9 | 149684 | 18955 | 64330084 |
Eosinophilic pneumonia chronic | 20.66 | 9.66 | 12 | 149681 | 353 | 64348686 |
Iron deficiency anaemia | 20.61 | 9.66 | 103 | 149590 | 21786 | 64327253 |
Discomfort | 20.59 | 9.66 | 107 | 149586 | 80771 | 64268268 |
Alanine aminotransferase increased | 20.42 | 9.66 | 215 | 149478 | 138816 | 64210223 |
Swelling | 20.33 | 9.66 | 256 | 149437 | 159962 | 64189077 |
Blood corticotrophin | 20.27 | 9.66 | 4 | 149689 | 0 | 64349039 |
Hypokalaemia | 20.23 | 9.66 | 183 | 149510 | 121720 | 64227319 |
Blood creatine phosphokinase increased | 20.15 | 9.66 | 69 | 149624 | 58489 | 64290550 |
Tinnitus | 20.11 | 9.66 | 142 | 149551 | 33991 | 64315048 |
Dyspnoea paroxysmal nocturnal | 20.04 | 9.66 | 24 | 149669 | 1980 | 64347059 |
Aplastic anaemia | 19.95 | 9.66 | 4 | 149689 | 13916 | 64335123 |
Procedural pain | 19.90 | 9.66 | 80 | 149613 | 15428 | 64333611 |
Nasal inflammation | 19.62 | 9.66 | 14 | 149679 | 590 | 64348449 |
Lung hernia | 19.60 | 9.66 | 7 | 149686 | 62 | 64348977 |
Blister | 19.57 | 9.66 | 109 | 149584 | 80858 | 64268181 |
Rheumatoid nodule | 19.52 | 9.66 | 3 | 149690 | 12648 | 64336391 |
Weight decreased | 19.51 | 9.66 | 830 | 148863 | 284909 | 64064130 |
Forced expiratory flow decreased | 19.44 | 9.66 | 10 | 149683 | 230 | 64348809 |
Bronchitis bacterial | 19.39 | 9.66 | 19 | 149674 | 1248 | 64347791 |
Palmar-plantar erythrodysaesthesia syndrome | 19.34 | 9.66 | 23 | 149670 | 28796 | 64320243 |
Candida infection | 19.27 | 9.66 | 132 | 149561 | 31287 | 64317752 |
Airway remodelling | 19.24 | 9.66 | 9 | 149684 | 167 | 64348872 |
Skin striae | 19.24 | 9.66 | 20 | 149673 | 1410 | 64347629 |
Osteoporosis | 19.21 | 9.66 | 165 | 149528 | 41915 | 64307124 |
Blood bilirubin increased | 19.01 | 9.66 | 69 | 149624 | 57484 | 64291555 |
Cystic fibrosis related diabetes | 19.00 | 9.66 | 9 | 149684 | 172 | 64348867 |
Respiratory tract infection | 18.86 | 9.66 | 150 | 149543 | 37257 | 64311782 |
Lymphopenia | 18.85 | 9.66 | 19 | 149674 | 25638 | 64323401 |
Nodular vasculitis | 18.82 | 9.66 | 6 | 149687 | 36 | 64349003 |
Swelling face | 18.73 | 9.66 | 215 | 149478 | 58951 | 64290088 |
Hypertrophic osteoarthropathy | 18.70 | 9.66 | 8 | 149685 | 119 | 64348920 |
Insomnia | 18.69 | 9.66 | 596 | 149097 | 197240 | 64151799 |
Expiratory reserve volume decreased | 18.68 | 9.66 | 7 | 149686 | 72 | 64348967 |
Acute respiratory distress syndrome | 18.60 | 9.66 | 39 | 149654 | 38896 | 64310143 |
Delirium | 18.49 | 9.66 | 90 | 149603 | 69104 | 64279935 |
Gluten sensitivity | 18.45 | 9.66 | 11 | 149682 | 340 | 64348699 |
Carcinoid tumour of the gastrointestinal tract | 18.43 | 9.66 | 7 | 149686 | 75 | 64348964 |
Shock haemorrhagic | 18.31 | 9.66 | 8 | 149685 | 16783 | 64332256 |
Drug eruption | 18.29 | 9.66 | 35 | 149658 | 36101 | 64312938 |
Pulmonary arterial hypertension | 18.27 | 9.66 | 111 | 149582 | 25256 | 64323783 |
Subarachnoid haemorrhage | 18.26 | 9.66 | 10 | 149683 | 18428 | 64330611 |
Sneezing | 18.25 | 9.66 | 77 | 149616 | 15174 | 64333865 |
Ankle fracture | 18.17 | 9.66 | 75 | 149618 | 14635 | 64334404 |
Affective disorder | 17.84 | 9.66 | 44 | 149649 | 6536 | 64342503 |
Labelled drug-drug interaction medication error | 17.79 | 9.66 | 15 | 149678 | 22047 | 64326992 |
Urinary tract infection | 17.72 | 9.66 | 681 | 149012 | 230915 | 64118124 |
Diastolic dysfunction | 17.69 | 9.66 | 53 | 149640 | 8822 | 64340217 |
Intentional self-injury | 17.62 | 9.66 | 25 | 149668 | 29019 | 64320020 |
Hyperthermia | 17.61 | 9.66 | 7 | 149686 | 15543 | 64333496 |
Ischaemic stroke | 17.60 | 9.66 | 25 | 149668 | 29010 | 64320029 |
Pharyngitis streptococcal | 17.50 | 9.66 | 52 | 149641 | 8616 | 64340423 |
Infusion site swelling | 17.49 | 9.66 | 39 | 149654 | 5426 | 64343613 |
Heart rate increased | 17.46 | 9.66 | 324 | 149369 | 98351 | 64250688 |
Osteonecrosis of jaw | 17.31 | 9.66 | 42 | 149651 | 39783 | 64309256 |
Acute myeloid leukaemia | 17.30 | 9.66 | 23 | 149670 | 27440 | 64321599 |
Sepsis | 17.21 | 9.66 | 405 | 149288 | 229936 | 64119103 |
Melaena | 17.16 | 9.66 | 65 | 149628 | 53483 | 64295556 |
Illness | 17.09 | 9.66 | 98 | 149595 | 21840 | 64327199 |
Inappropriate antidiuretic hormone secretion | 16.96 | 9.66 | 16 | 149677 | 22273 | 64326766 |
Sinus headache | 16.95 | 9.66 | 33 | 149660 | 4174 | 64344865 |
Peak expiratory flow rate decreased | 16.91 | 9.66 | 13 | 149680 | 615 | 64348424 |
Proteinuria | 16.68 | 9.66 | 24 | 149669 | 27699 | 64321340 |
Fracture displacement | 16.65 | 9.66 | 17 | 149676 | 1174 | 64347865 |
Stevens-Johnson syndrome | 16.62 | 9.66 | 34 | 149659 | 34215 | 64314824 |
Encephalopathy | 16.61 | 9.66 | 75 | 149618 | 58744 | 64290295 |
Drug level increased | 16.55 | 9.66 | 34 | 149659 | 34162 | 64314877 |
Laryngeal pain | 16.54 | 9.66 | 39 | 149654 | 5629 | 64343410 |
Acute generalised exanthematous pustulosis | 16.47 | 9.66 | 6 | 149687 | 14052 | 64334987 |
Fluid retention | 16.43 | 9.66 | 211 | 149482 | 59395 | 64289644 |
Limb injury | 16.39 | 9.66 | 102 | 149591 | 23403 | 64325636 |
Muscle spasms | 16.37 | 9.66 | 436 | 149257 | 140587 | 64208452 |
Torsade de pointes | 16.36 | 9.66 | 10 | 149683 | 17353 | 64331686 |
Oral candidiasis | 16.36 | 9.66 | 101 | 149592 | 23111 | 64325928 |
Painful respiration | 16.03 | 9.66 | 27 | 149666 | 3054 | 64345985 |
Therapeutic product effect incomplete | 16.02 | 9.66 | 333 | 149360 | 103149 | 64245890 |
Ear discomfort | 15.98 | 9.66 | 45 | 149648 | 7235 | 64341804 |
Cytopenia | 15.90 | 9.66 | 8 | 149685 | 15463 | 64333576 |
Intentional product use issue | 15.89 | 9.66 | 143 | 149550 | 95221 | 64253818 |
Throat tightness | 15.84 | 9.66 | 100 | 149593 | 23060 | 64325979 |
Cytomegalovirus viraemia | 15.76 | 9.66 | 3 | 149690 | 10825 | 64338214 |
Cardiac septal defect | 15.67 | 9.66 | 9 | 149684 | 259 | 64348780 |
Disease progression | 15.59 | 9.66 | 233 | 149460 | 141447 | 64207592 |
Pruritus | 15.57 | 9.66 | 880 | 148813 | 311520 | 64037519 |
Musculoskeletal stiffness | 15.57 | 9.66 | 197 | 149496 | 123009 | 64226030 |
Respiratory syncytial virus bronchiolitis | 15.53 | 9.66 | 11 | 149682 | 458 | 64348581 |
Brain oedema | 15.48 | 9.66 | 17 | 149676 | 22058 | 64326981 |
Paraesthesia oral | 15.48 | 9.66 | 66 | 149627 | 13065 | 64335974 |
Obesity | 15.47 | 9.66 | 91 | 149602 | 20471 | 64328568 |
Abnormal behaviour | 15.43 | 9.66 | 132 | 149561 | 33490 | 64315549 |
Eosinophil count abnormal | 15.38 | 9.66 | 12 | 149681 | 580 | 64348459 |
Hyponatraemia | 15.29 | 9.66 | 247 | 149446 | 148092 | 64200947 |
Temperature intolerance | 15.25 | 9.66 | 48 | 149645 | 8207 | 64340832 |
Ear canal erythema | 15.20 | 9.66 | 3 | 149690 | 0 | 64349039 |
Increased viscosity of bronchial secretion | 15.20 | 9.66 | 11 | 149682 | 474 | 64348565 |
Bronchoscopy | 15.19 | 9.66 | 6 | 149687 | 72 | 64348967 |
Metastases to bone | 15.16 | 9.66 | 15 | 149678 | 20420 | 64328619 |
Injection site inflammation | 15.15 | 9.66 | 27 | 149666 | 3194 | 64345845 |
Circulatory collapse | 15.12 | 9.66 | 35 | 149658 | 33697 | 64315342 |
Transplant rejection | 15.08 | 9.66 | 11 | 149682 | 17390 | 64331649 |
Smoke sensitivity | 15.08 | 9.66 | 11 | 149682 | 480 | 64348559 |
Diabetic ketoacidosis | 15.02 | 9.66 | 29 | 149664 | 29816 | 64319223 |
Disseminated intravascular coagulation | 14.96 | 9.66 | 33 | 149660 | 32315 | 64316724 |
Hysterectomy | 14.85 | 9.66 | 35 | 149658 | 5050 | 64343989 |
Multiple allergies | 14.84 | 9.66 | 38 | 149655 | 5776 | 64343263 |
Lymphocyte count decreased | 14.66 | 9.66 | 47 | 149646 | 40652 | 64308387 |
Hot flush | 14.63 | 9.66 | 168 | 149525 | 46067 | 64302972 |
Tricuspid valve incompetence | 14.61 | 9.66 | 78 | 149615 | 16925 | 64332114 |
Mobility decreased | 14.61 | 9.66 | 128 | 149565 | 85712 | 64263327 |
Hepatitis cholestatic | 14.56 | 9.66 | 5 | 149688 | 12150 | 64336889 |
Rhinovirus infection | 14.45 | 9.66 | 39 | 149654 | 6117 | 64342922 |
Acute hepatic failure | 14.38 | 9.66 | 24 | 149669 | 26088 | 64322951 |
Road traffic accident | 14.27 | 9.66 | 121 | 149572 | 30624 | 64318415 |
Pre-existing condition improved | 14.15 | 9.66 | 33 | 149660 | 4729 | 64344310 |
Hyperbilirubinaemia | 14.15 | 9.66 | 17 | 149676 | 21188 | 64327851 |
Gastroenteritis viral | 14.00 | 9.66 | 86 | 149607 | 19643 | 64329396 |
Parkinsonism | 13.94 | 9.66 | 8 | 149685 | 14365 | 64334674 |
Central nervous system mass | 13.92 | 9.66 | 6 | 149687 | 91 | 64348948 |
Tubulointerstitial nephritis | 13.91 | 9.66 | 32 | 149661 | 30877 | 64318162 |
Pneumococcal infection | 13.87 | 9.66 | 13 | 149680 | 808 | 64348231 |
Respiratory tract irritation | 13.78 | 9.66 | 11 | 149682 | 550 | 64348489 |
Chronic respiratory failure | 13.77 | 9.66 | 23 | 149670 | 2583 | 64346456 |
Haematuria | 13.76 | 9.66 | 83 | 149610 | 60388 | 64288651 |
Pneumonia aspiration | 13.67 | 9.66 | 81 | 149612 | 59190 | 64289849 |
Wall motion score index abnormal | 13.58 | 9.66 | 6 | 149687 | 97 | 64348942 |
Eosinophilic oesophagitis | 13.36 | 9.66 | 10 | 149683 | 454 | 64348585 |
Croup infectious | 13.34 | 9.66 | 11 | 149682 | 576 | 64348463 |
Epilepsy | 13.32 | 9.66 | 37 | 149656 | 33494 | 64315545 |
Nocturnal dyspnoea | 13.30 | 9.66 | 16 | 149677 | 1326 | 64347713 |
Polyneuropathy | 13.22 | 9.66 | 16 | 149677 | 19878 | 64329161 |
Haemoglobin decreased | 13.21 | 9.66 | 348 | 149345 | 194715 | 64154324 |
Atopy | 13.17 | 9.66 | 8 | 149685 | 256 | 64348783 |
Fracture pain | 13.14 | 9.66 | 9 | 149684 | 355 | 64348684 |
Bronchial wall thickening | 13.11 | 9.66 | 19 | 149674 | 1888 | 64347151 |
Hilar lymphadenopathy | 12.97 | 9.66 | 17 | 149676 | 1536 | 64347503 |
Pemphigoid | 12.92 | 9.66 | 7 | 149686 | 12979 | 64336060 |
Hypomagnesaemia | 12.89 | 9.66 | 44 | 149649 | 37332 | 64311707 |
Haemolytic anaemia | 12.84 | 9.66 | 11 | 149682 | 16042 | 64332997 |
Aspartate aminotransferase increased | 12.83 | 9.66 | 198 | 149495 | 119590 | 64229449 |
Dermatitis contact | 12.83 | 9.66 | 48 | 149645 | 8952 | 64340087 |
Hypersomnia | 12.79 | 9.66 | 84 | 149609 | 19633 | 64329406 |
Lung opacity | 12.78 | 9.66 | 25 | 149668 | 3174 | 64345865 |
Lemierre syndrome | 12.75 | 9.66 | 6 | 149687 | 113 | 64348926 |
Pain in extremity | 12.72 | 9.66 | 841 | 148852 | 302244 | 64046795 |
Cardiogenic shock | 12.72 | 9.66 | 36 | 149657 | 32391 | 64316648 |
Anger | 12.71 | 9.66 | 71 | 149622 | 15670 | 64333369 |
Periarthritis | 12.70 | 9.66 | 22 | 149671 | 2545 | 64346494 |
Therapy partial responder | 12.66 | 9.66 | 4 | 149689 | 10244 | 64338795 |
Stridor | 12.59 | 9.66 | 32 | 149661 | 4842 | 64344197 |
Electrocardiogram QRS complex prolonged | 12.55 | 9.66 | 3 | 149690 | 9241 | 64339798 |
Hyperuricaemia | 12.55 | 9.66 | 4 | 149689 | 10187 | 64338852 |
Carpal tunnel syndrome | 12.53 | 9.66 | 71 | 149622 | 15757 | 64333282 |
Immune thrombocytopenia | 12.45 | 9.66 | 10 | 149683 | 15056 | 64333983 |
Musculoskeletal chest pain | 12.44 | 9.66 | 89 | 149604 | 21390 | 64327649 |
Purpura | 12.41 | 9.66 | 13 | 149680 | 17233 | 64331806 |
Psychotic disorder | 12.41 | 9.66 | 40 | 149653 | 34538 | 64314501 |
Hip arthroplasty | 12.34 | 9.66 | 19 | 149674 | 21332 | 64327707 |
Arthropod bite | 12.34 | 9.66 | 39 | 149654 | 6682 | 64342357 |
Educational problem | 12.29 | 9.66 | 9 | 149684 | 395 | 64348644 |
Hypercalcaemia | 12.23 | 9.66 | 35 | 149658 | 31381 | 64317658 |
Tendon calcification | 12.20 | 9.66 | 6 | 149687 | 125 | 64348914 |
Loss of personal independence in daily activities | 12.16 | 9.66 | 236 | 149457 | 72218 | 64276821 |
Glucocorticoids increased | 12.16 | 9.66 | 6 | 149687 | 126 | 64348913 |
Ascites | 12.15 | 9.66 | 89 | 149604 | 61912 | 64287127 |
Product substitution issue | 12.14 | 9.66 | 77 | 149616 | 17784 | 64331255 |
Panic reaction | 12.07 | 9.66 | 28 | 149665 | 3999 | 64345040 |
FEV1/FVC ratio decreased | 12.07 | 9.66 | 6 | 149687 | 128 | 64348911 |
Cystitis interstitial | 12.05 | 9.66 | 14 | 149679 | 1118 | 64347921 |
Blood urea increased | 12.05 | 9.66 | 57 | 149636 | 44096 | 64304943 |
Myalgia | 12.02 | 9.66 | 466 | 149227 | 158151 | 64190888 |
Peritonitis | 12.01 | 9.66 | 25 | 149668 | 24998 | 64324041 |
Cortisol abnormal | 11.96 | 9.66 | 5 | 149688 | 70 | 64348969 |
Vena cava embolism | 11.92 | 9.66 | 3 | 149690 | 6 | 64349033 |
Malaise | 11.90 | 9.66 | 1071 | 148622 | 395176 | 63953863 |
Child abuse | 11.84 | 9.66 | 7 | 149686 | 213 | 64348826 |
Hereditary angioedema | 11.67 | 9.66 | 27 | 149666 | 3849 | 64345190 |
Bronchial secretion retention | 11.65 | 9.66 | 21 | 149672 | 2506 | 64346533 |
Nightmare | 11.59 | 9.66 | 86 | 149607 | 20907 | 64328132 |
Fracture | 11.52 | 9.66 | 16 | 149677 | 18739 | 64330300 |
Penile erythema | 11.47 | 9.66 | 6 | 149687 | 143 | 64348896 |
Eye disorder | 11.41 | 9.66 | 79 | 149614 | 18790 | 64330249 |
Enuresis | 11.38 | 9.66 | 22 | 149671 | 2768 | 64346271 |
Snoring | 11.33 | 9.66 | 30 | 149663 | 4652 | 64344387 |
Anaphylactic reaction | 11.30 | 9.66 | 223 | 149470 | 68441 | 64280598 |
Kidney transplant rejection | 11.24 | 9.66 | 4 | 149689 | 9507 | 64339532 |
Dry skin | 11.24 | 9.66 | 174 | 149519 | 50987 | 64298052 |
Expired product administered | 11.23 | 9.66 | 35 | 149658 | 5952 | 64343087 |
Memory impairment | 11.15 | 9.66 | 269 | 149424 | 85413 | 64263626 |
Increased bronchial secretion | 11.10 | 9.66 | 22 | 149671 | 2820 | 64346219 |
IPEX syndrome | 11.07 | 9.66 | 3 | 149690 | 9 | 64349030 |
Neurotoxicity | 11.06 | 9.66 | 30 | 149663 | 27374 | 64321665 |
Staphylococcal infection | 11.00 | 9.66 | 172 | 149521 | 50506 | 64298533 |
Total lung capacity abnormal | 10.96 | 9.66 | 6 | 149687 | 157 | 64348882 |
Vitamin D decreased | 10.96 | 9.66 | 41 | 149652 | 7646 | 64341393 |
Bacterial tracheitis | 10.96 | 9.66 | 4 | 149689 | 38 | 64349001 |
Insulin autoimmune syndrome | 10.93 | 9.66 | 8 | 149685 | 351 | 64348688 |
Bronchopulmonary aspergillosis allergic | 10.92 | 9.66 | 16 | 149677 | 1606 | 64347433 |
Therapy non-responder | 10.89 | 9.66 | 99 | 149594 | 65800 | 64283239 |
Inflammation | 10.84 | 9.66 | 98 | 149595 | 65202 | 64283837 |
Transaminases increased | 10.79 | 9.66 | 60 | 149633 | 44534 | 64304505 |
Cholecystectomy | 10.76 | 9.66 | 42 | 149651 | 7990 | 64341049 |
Electrocardiogram ST-T segment abnormal | 10.76 | 9.66 | 9 | 149684 | 481 | 64348558 |
Device dislocation | 10.71 | 9.66 | 85 | 149608 | 21093 | 64327946 |
Gallbladder disorder | 10.71 | 9.66 | 72 | 149621 | 16958 | 64332081 |
Dystonia | 10.70 | 9.66 | 17 | 149676 | 18848 | 64330191 |
Stress fracture | 10.66 | 9.66 | 33 | 149660 | 5591 | 64343448 |
Back pain | 10.64 | 9.66 | 695 | 148998 | 249476 | 64099563 |
Muscle rigidity | 10.64 | 9.66 | 15 | 149678 | 17458 | 64331581 |
Thermal burn | 10.60 | 9.66 | 34 | 149659 | 5872 | 64343167 |
Distal intestinal obstruction syndrome | 10.58 | 9.66 | 10 | 149683 | 628 | 64348411 |
Irritability | 10.52 | 9.66 | 131 | 149562 | 36615 | 64312424 |
Otitis media | 10.48 | 9.66 | 32 | 149661 | 5381 | 64343658 |
Restlessness | 10.48 | 9.66 | 52 | 149641 | 39733 | 64309306 |
Food allergy | 10.47 | 9.66 | 41 | 149652 | 7810 | 64341229 |
Metastases to lung | 10.44 | 9.66 | 12 | 149681 | 15252 | 64333787 |
Right ventricular systolic pressure | 10.40 | 9.66 | 3 | 149690 | 12 | 64349027 |
Pituitary-dependent Cushing's syndrome | 10.40 | 9.66 | 3 | 149690 | 12 | 64349027 |
Senile osteoporosis | 10.40 | 9.66 | 5 | 149688 | 99 | 64348940 |
Atypical fracture | 10.35 | 9.66 | 10 | 149683 | 646 | 64348393 |
Akathisia | 10.34 | 9.66 | 7 | 149686 | 11503 | 64337536 |
Hirsutism | 10.30 | 9.66 | 12 | 149681 | 961 | 64348078 |
Pickwickian syndrome | 10.28 | 9.66 | 8 | 149685 | 385 | 64348654 |
Gallbladder injury | 10.27 | 9.66 | 13 | 149680 | 1135 | 64347904 |
Meralgia paraesthetica | 10.27 | 9.66 | 7 | 149686 | 274 | 64348765 |
Vascular parkinsonism | 10.22 | 9.66 | 5 | 149688 | 103 | 64348936 |
Hypoaesthesia | 10.15 | 9.66 | 407 | 149286 | 138701 | 64210338 |
Lip swelling | 10.12 | 9.66 | 116 | 149577 | 31791 | 64317248 |
Cystitis | 10.10 | 9.66 | 147 | 149546 | 42528 | 64306511 |
Ventricular tachycardia | 10.09 | 9.66 | 43 | 149650 | 34222 | 64314817 |
Cataplexy | 10.08 | 9.66 | 11 | 149682 | 820 | 64348219 |
Orthopnoea | 10.07 | 9.66 | 45 | 149648 | 9089 | 64339950 |
Uterine perforation | 9.99 | 9.66 | 33 | 149660 | 5787 | 64343252 |
Vulvovaginal discomfort | 9.98 | 9.66 | 15 | 149678 | 1540 | 64347499 |
Transplant evaluation | 9.96 | 9.66 | 15 | 149678 | 1542 | 64347497 |
Asthmatic crisis | 9.96 | 9.66 | 16 | 149677 | 1740 | 64347299 |
Pharyngeal erythema | 9.94 | 9.66 | 16 | 149677 | 1743 | 64347296 |
Antineutrophil cytoplasmic antibody positive | 9.92 | 9.66 | 12 | 149681 | 1000 | 64348039 |
Febrile bone marrow aplasia | 9.91 | 9.66 | 7 | 149686 | 11248 | 64337791 |
Mood swings | 9.90 | 9.66 | 72 | 149621 | 17396 | 64331643 |
Neuroendocrine tumour of the lung metastatic | 9.88 | 9.66 | 5 | 149688 | 111 | 64348928 |
Obsessive-compulsive disorder | 9.82 | 9.66 | 29 | 149664 | 4789 | 64344250 |
Live birth | 9.82 | 9.66 | 7 | 149686 | 11197 | 64337842 |
Progressive multifocal leukoencephalopathy | 9.81 | 9.66 | 17 | 149676 | 18215 | 64330824 |
Accidental exposure to product | 9.81 | 9.66 | 30 | 149663 | 26334 | 64322705 |
Oedema peripheral | 9.81 | 9.66 | 589 | 149104 | 209728 | 64139311 |
Eye discharge | 9.80 | 9.66 | 30 | 149663 | 5054 | 64343985 |
Arthritis bacterial | 9.79 | 9.66 | 3 | 149690 | 7836 | 64341203 |
Femoral neck fracture | 9.76 | 9.66 | 4 | 149689 | 8720 | 64340319 |
Nephrotic syndrome | 9.75 | 9.66 | 5 | 149688 | 9562 | 64339477 |
Vocal cord atrophy | 9.70 | 9.66 | 3 | 149690 | 16 | 64349023 |
Product taste abnormal | 9.69 | 9.66 | 17 | 149676 | 1986 | 64347053 |
Secretion discharge | 9.69 | 9.66 | 54 | 149639 | 11910 | 64337129 |
Blood pressure inadequately controlled | 9.66 | 9.66 | 31 | 149662 | 5353 | 64343686 |
None
Source | Code | Description |
---|---|---|
ATC | D07AC17 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III) |
ATC | R01AD08 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
ATC | R01AD58 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
ATC | R03AK06 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
ATC | R03AK11 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
ATC | R03BA05 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids |
FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
FDA EPC | N0000175576 | Corticosteroid |
CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
CHEBI has role | CHEBI:50857 | anti-allergic drugs |
MeSH PA | D018926 | Anti-Allergic Agents |
MeSH PA | D018927 | Anti-Asthmatic Agents |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D001993 | Bronchodilator Agents |
MeSH PA | D003879 | Dermatologic Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D019141 | Respiratory System Agents |
CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
CHEBI has role | CHEBI:35523 | bronchodilator |
CHEBI has role | CHEBI:37962 | adrenergic agents |
CHEBI has role | CHEBI:50177 | dermatologic agent |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Atopic dermatitis | indication | 24079001 | DOID:3310 |
Contact dermatitis | indication | 40275004 | DOID:2773 |
Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
Lichen simplex chronicus | indication | 53891004 | |
Allergic rhinitis | indication | 61582004 | |
Granuloma annulare | indication | 65508009 | DOID:3777 |
Pulmonary emphysema | indication | 87433001 | |
Pruritus ani | indication | 90446007 | |
Discoid lupus erythematosus | indication | 200938002 | |
Plaque psoriasis | indication | 200965009 | |
Scalp psoriasis | indication | 238608008 | |
Non-allergic asthma | indication | 266361008 | DOID:9360 |
Pruritus of genital organs | indication | 267802000 | |
Eruption of skin | indication | 271807003 | DOID:0050486 |
Allergic asthma | indication | 389145006 | DOID:9415 |
Primary cutaneous T-cell lymphoma | indication | 400122007 | |
Asthma management | indication | 406162001 | |
Chronic Non-Allergic Rhinitis | indication | ||
Bronchospasm Prevention with COPD | indication | ||
COPD Associated with Chronic Bronchitis | indication | ||
Severe chronic obstructive pulmonary disease | off-label use | 313299006 | |
Mycosis | contraindication | 3218000 | DOID:1564 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Inactive tuberculosis | contraindication | 11999007 | |
Epistaxis | contraindication | 12441001 | |
Measles | contraindication | 14189004 | DOID:8622 |
Disease caused by parasite | contraindication | 17322007 | |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Acute tuberculosis | contraindication | 25629007 | |
Viral disease | contraindication | 34014006 | DOID:934 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Hypokalemia | contraindication | 43339004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Hypercortisolism | contraindication | 47270006 | |
Ketoacidosis | contraindication | 56051008 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hypopituitarism | contraindication | 74728003 | DOID:9406 |
Candidiasis of mouth | contraindication | 79740000 | DOID:14262 |
Perforation of nasal septum | contraindication | 80142000 | |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Bacterial infectious disease | contraindication | 87628006 | |
Operation on nose | contraindication | 88733004 | |
Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
Bilateral cataracts | contraindication | 95722004 | |
Prolonged QT interval | contraindication | 111975006 | |
Seizure disorder | contraindication | 128613002 | |
Pulmonary tuberculosis | contraindication | 154283005 | DOID:2957 |
Ophthalmic herpes simplex | contraindication | 186542001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Telangiectasia disorder | contraindication | 247479008 | |
Exacerbation of asthma | contraindication | 281239006 | |
Varicella-zoster virus infection | contraindication | 309465005 | |
Osteopenia | contraindication | 312894000 | |
Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
Atrophoderma | contraindication | 399979006 | |
Peripheral vascular disease | contraindication | 400047006 | |
Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
Congenital long QT syndrome | contraindication | 442917000 | |
Exposure to varicella | contraindication | 444453009 | |
Untreated Fungal Infection | contraindication | ||
Nasal Septal Ulcers | contraindication | ||
Uncontrolled Bacterial Infections | contraindication | ||
Nasal Candidiasis | contraindication | ||
Nasal Trauma | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.49 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
0.137MG/SPRAY;0.05MG/SPRAY | DYMISTA | MYLAN SPECIALITY LP | N202236 | May 1, 2012 | RX | SPRAY, METERED | NASAL | 9259428 | June 13, 2023 | TREATMENT OF SEASONAL ALLERGIC RHINITIS |
0.137MG/SPRAY;0.05MG/SPRAY | DYMISTA | MYLAN SPECIALITY LP | N202236 | May 1, 2012 | RX | SPRAY, METERED | NASAL | 8163723 | Aug. 29, 2023 | ALLERGIC RHINITIS |
0.137MG/SPRAY;0.05MG/SPRAY | DYMISTA | MYLAN SPECIALITY LP | N202236 | May 1, 2012 | RX | SPRAY, METERED | NASAL | 8163723 | Aug. 29, 2023 | RELIEF OF SYMPTOMS ASSOCIATED WITH SEASONAL ALLERGIC RHINITIS |
0.137MG/SPRAY;0.05MG/SPRAY | DYMISTA | MYLAN SPECIALITY LP | N202236 | May 1, 2012 | RX | SPRAY, METERED | NASAL | 8163723 | Aug. 29, 2023 | TREATMENT OF ALLERGIC RHINITIS, INCLUDING SEASONAL ALLERGIC RHINITIS |
0.137MG/SPRAY;0.05MG/SPRAY | DYMISTA | MYLAN SPECIALITY LP | N202236 | May 1, 2012 | RX | SPRAY, METERED | NASAL | 8163723 | Aug. 29, 2023 | TREATMENT OF SEASONAL ALLERGIC RHINITIS |
0.137MG/SPRAY;0.05MG/SPRAY | DYMISTA | MYLAN SPECIALITY LP | N202236 | May 1, 2012 | RX | SPRAY, METERED | NASAL | 8163723 | Aug. 29, 2023 | TREATMENT OF SYMPTOMS OF SEASONAL ALLERGIC RHINITIS |
0.093MG | XHANCE | OPTINOSE US INC | N209022 | Sept. 18, 2017 | RX | SPRAY, METERED | NASAL | 8327844 | Oct. 8, 2023 | METHOD OF DELIVERING FLUTICASONE PROPIONATE TO A NASAL AIRWAY |
0.093MG | XHANCE | OPTINOSE US INC | N209022 | Sept. 18, 2017 | RX | SPRAY, METERED | NASAL | 7975690 | Dec. 29, 2025 | METHOD OF DELIVERING FLUTICASONE PROPIONATE TO A NASAL AIRWAY |
0.093MG | XHANCE | OPTINOSE US INC | N209022 | Sept. 18, 2017 | RX | SPRAY, METERED | NASAL | 10124132 | March 6, 2027 | METHOD OF DELIVERING FLUTICASONE PROPIONATE TO A NASAL AIRWAY |
0.093MG | XHANCE | OPTINOSE US INC | N209022 | Sept. 18, 2017 | RX | SPRAY, METERED | NASAL | 10076615 | July 30, 2029 | METHOD OF DELIVERING FLUTICASONE PROPIONATE TO A NASAL AIRWAY |
0.093MG | XHANCE | OPTINOSE US INC | N209022 | Sept. 18, 2017 | RX | SPRAY, METERED | NASAL | 10179216 | July 8, 2033 | METHOD OF DELIVERING FLUTICASONE PROPIONATE TO A NASAL AIRWAY |
0.093MG | XHANCE | OPTINOSE US INC | N209022 | Sept. 18, 2017 | RX | SPRAY, METERED | NASAL | 10478574 | Nov. 4, 2033 | METHOD OF DELIVERING FLUTICASONE PROPIONATE TO A NASAL AIRWAY |
0.055MG/INH;EQ 0.014MG BASE/INH | AIRDUO DIGIHALER | TEVA PHARM | N208799 | July 12, 2019 | RX | POWDER | INHALATION | 9066957 | Oct. 6, 2034 | TREATMENT OF ASTHMA |
0.055MG/INH;EQ 0.014MG BASE/INH | AIRDUO RESPICLICK | TEVA PHARM | N208799 | Jan. 27, 2017 | RX | POWDER | INHALATION | 9066957 | Oct. 6, 2034 | TREATMENT OF ASTHMA |
0.055MG/INH;EQ 0.014MG BASE/INH | AIRDUO DIGIHALER | TEVA PHARM | N208799 | July 12, 2019 | RX | POWDER | INHALATION | 9415008 | Oct. 6, 2034 | TREATMENT OF ASTHMA |
0.055MG/INH;EQ 0.014MG BASE/INH | AIRDUO RESPICLICK | TEVA PHARM | N208799 | Jan. 27, 2017 | RX | POWDER | INHALATION | 9415008 | Oct. 6, 2034 | TREATMENT OF ASTHMA |
0.113MG/INH;EQ 0.014MG BASE/INH | AIRDUO DIGIHALER | TEVA PHARM | N208799 | July 12, 2019 | RX | POWDER | INHALATION | 9066957 | Oct. 6, 2034 | TREATMENT OF ASTHMA |
0.113MG/INH;EQ 0.014MG BASE/INH | AIRDUO RESPICLICK | TEVA PHARM | N208799 | Jan. 27, 2017 | RX | POWDER | INHALATION | 9066957 | Oct. 6, 2034 | TREATMENT OF ASTHMA |
0.232MG/INH;EQ 0.014MG BASE/INH | AIRDUO DIGIHALER | TEVA PHARM | N208799 | July 12, 2019 | RX | POWDER | INHALATION | 9066957 | Oct. 6, 2034 | TREATMENT OF ASTHMA |
0.232MG/INH;EQ 0.014MG BASE/INH | AIRDUO RESPICLICK | TEVA PHARM | N208799 | Jan. 27, 2017 | RX | POWDER | INHALATION | 9066957 | Oct. 6, 2034 | TREATMENT OF ASTHMA |
0.093MG | XHANCE | OPTINOSE US INC | N209022 | Sept. 18, 2017 | RX | SPRAY, METERED | NASAL | 10300229 | July 7, 2035 | METHOD OF DELIVERING FLUTICASONE PROPIONATE TO A NASAL AIRWAY |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
0.03MG/INH | ARMONAIR RESPICLICK | TEVA PHARM | N208798 | July 9, 2021 | DISCN | POWDER | INHALATION | July 9, 2024 | NEW STRENGTH |
0.055MG/INH | ARMONAIR DIGIHALER | TEVA PHARM | N208798 | Feb. 20, 2020 | RX | POWDER | INHALATION | July 9, 2024 | NEW PATIENT POPULATION |
0.055MG/INH | ARMONAIR RESPICLICK | TEVA PHARM | N208798 | Jan. 27, 2017 | DISCN | POWDER | INHALATION | July 9, 2024 | NEW PATIENT POPULATION |
0.055MG/INH;EQ 0.014MG BASE/INH | AIRDUO DIGIHALER | TEVA PHARM | N208799 | July 12, 2019 | RX | POWDER | INHALATION | July 9, 2024 | REVISIONS TO LABELING BASED ON DATA SUBMITTED IN RESPONSE TO PEDIATRIC WRITTEN REQUEST |
0.055MG/INH;EQ 0.014MG BASE/INH | AIRDUO RESPICLICK | TEVA PHARM | N208799 | Jan. 27, 2017 | RX | POWDER | INHALATION | July 9, 2024 | REVISIONS TO LABELING BASED ON DATA SUBMITTED IN RESPONSE TO PEDIATRIC WRITTEN REQUEST |
0.03MG/INH | ARMONAIR RESPICLICK | TEVA PHARM | N208798 | July 9, 2021 | DISCN | POWDER | INHALATION | Jan. 9, 2025 | PEDIATRIC EXCLUSIVITY |
0.055MG/INH | ARMONAIR DIGIHALER | TEVA PHARM | N208798 | Feb. 20, 2020 | RX | POWDER | INHALATION | Jan. 9, 2025 | PEDIATRIC EXCLUSIVITY |
0.055MG/INH | ARMONAIR RESPICLICK | TEVA PHARM | N208798 | Jan. 27, 2017 | DISCN | POWDER | INHALATION | Jan. 9, 2025 | PEDIATRIC EXCLUSIVITY |
0.055MG/INH;EQ 0.014MG BASE/INH | AIRDUO DIGIHALER | TEVA PHARM | N208799 | July 12, 2019 | RX | POWDER | INHALATION | Jan. 9, 2025 | PEDIATRIC EXCLUSIVITY |
0.055MG/INH;EQ 0.014MG BASE/INH | AIRDUO RESPICLICK | TEVA PHARM | N208799 | Jan. 27, 2017 | RX | POWDER | INHALATION | Jan. 9, 2025 | PEDIATRIC EXCLUSIVITY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | EC50 | 10.74 | WOMBAT-PK | CHEMBL | |||
Mineralocorticoid receptor | Nuclear hormone receptor | AGONIST | EC50 | 6.83 | IUPHAR | ||||
Progesterone receptor | Nuclear hormone receptor | AGONIST | EC50 | 9.77 | WOMBAT-PK | ||||
Cytosolic phospholipase A2 | Enzyme | WOMBAT-PK | |||||||
Glucocorticoid receptor | Transcription factor | EC50 | 9.12 | CHEMBL |
ID | Source |
---|---|
4020180 | VUID |
N0000148122 | NUI |
D01708 | KEGG_DRUG |
4020180 | VANDF |
4020529 | VANDF |
C0117996 | UMLSCUI |
CHEBI:31441 | CHEBI |
CHEBI:5134 | CHEBI |
CHEMBL1473 | ChEMBL_ID |
D000068298 | MESH_DESCRIPTOR_UI |
DB00588 | DRUGBANK_ID |
7080 | IUPHAR_LIGAND_ID |
6699 | IUPHAR_LIGAND_ID |
90566-53-3 | SECONDARY_CAS_RN |
O2GMZ0LF5W | UNII |
444036 | PUBCHEM_CID |
5311101 | PUBCHEM_CID |
DB13867 | DRUGBANK_ID |
41126 | RXNORM |
4756 | MMSL |
51966 | MMSL |
81052 | MMSL |
d01296 | MMSL |
003593 | NDDF |
004952 | NDDF |
108632003 | SNOMEDCT_US |
396064000 | SNOMEDCT_US |
397192001 | SNOMEDCT_US |
C0082607 | UMLSCUI |
CHEMBL1201396 | ChEMBL_ID |
5636 | INN_ID |
CUT2W21N7U | UNII |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
DYMISTA | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0037-0245 | SPRAY, METERED | 50 ug | NASAL | NDA | 28 sections |
fluticasone propionate and salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0054-0326 | POWDER | 100 ug | RESPIRATORY (INHALATION) | ANDA | 28 sections |
fluticasone propionate and salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0054-0327 | POWDER | 250 ug | RESPIRATORY (INHALATION) | ANDA | 28 sections |
Fluticasone Propionate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-3270 | SPRAY, METERED | 50 ug | NASAL | ANDA | 26 sections |
Fluticasone Propionate and Salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-3607 | POWDER, METERED | 55 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 28 sections |
Fluticasone Propionate and Salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-3607 | POWDER, METERED | 55 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 28 sections |
Fluticasone Propionate and Salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-3608 | POWDER, METERED | 113 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 28 sections |
Fluticasone Propionate and Salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-3608 | POWDER, METERED | 113 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 28 sections |
Fluticasone Propionate and Salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-3609 | POWDER, METERED | 232 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 28 sections |
Fluticasone Propionate and Salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-3609 | POWDER, METERED | 232 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 28 sections |
fluticasone propionate and salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-7516 | POWDER | 500 ug | RESPIRATORY (INHALATION) | ANDA | 28 sections |
fluticasone propionate and salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-7517 | POWDER | 100 ug | RESPIRATORY (INHALATION) | ANDA | 28 sections |
fluticasone propionate and salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-7518 | POWDER | 250 ug | RESPIRATORY (INHALATION) | ANDA | 28 sections |
Good Sense 24 hour allergy nasal | HUMAN OTC DRUG LABEL | 1 | 0113-0028 | SPRAY, METERED | 50 ug | NASAL | ANDA | 17 sections |
Good Sense 24 hour allergy nasal | HUMAN OTC DRUG LABEL | 1 | 0113-0028 | SPRAY, METERED | 50 ug | NASAL | ANDA | 17 sections |
Good Sense 24 hour allergy nasal | HUMAN OTC DRUG LABEL | 1 | 0113-0285 | SPRAY, METERED | 50 ug | NASAL | ANDA | 17 sections |
basic care allergy relief nasal | HUMAN OTC DRUG LABEL | 1 | 0113-7117 | SPRAY, METERED | 50 ug | NASAL | ANDA | 17 sections |
FLONASEALLERGY RELIEF | HUMAN OTC DRUG LABEL | 1 | 0135-0576 | SPRAY, METERED | 50 ug | NASAL | NDA | 16 sections |
CHILDRENS FLONASEALLERGY RELIEF | HUMAN OTC DRUG LABEL | 1 | 0135-0582 | SPRAY, METERED | 50 ug | NASAL | NDA | 16 sections |
CHILDRENS FLONASEALLERGY RELIEF | HUMAN OTC DRUG LABEL | 1 | 0135-0582 | SPRAY, METERED | 50 ug | NASAL | NDA | 16 sections |
FLUTICASONE PROPIONATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0332 | CREAM | 0.50 mg | TOPICAL | ANDA | 21 sections |
FLUTICASONE PROPIONATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0434 | LOTION | 0.50 mg | TOPICAL | NDA authorized generic | 26 sections |
FLOVENTDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0600 | POWDER, METERED | 50 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
FLOVENTDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0600 | POWDER, METERED | 50 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
FLOVENTDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0601 | POWDER, METERED | 250 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
FLOVENTDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0601 | POWDER, METERED | 250 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
FLOVENTDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0602 | POWDER, METERED | 100 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
FLOVENTDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0602 | POWDER, METERED | 100 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
ADVAIRDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0695 | POWDER | 100 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |
ADVAIRDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0695 | POWDER | 100 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |