prednylidene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2254 599-33-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednylidene
  • dacorsol
  • dacortilen
  • decortilen
  • Molecular weight: 372.46
  • Formula: C22H28O5
  • CLOGP: 1.86
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.02
  • ROTB: 2

Drug dosage:

DoseUnitRoute
12 mg O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.804 Moderate 0.72
caco2-efflux Caco-2 efflux ratio (BA/AB) 8.710 Moderate 0.72
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 30.620 10^-6 cm/s Moderate 0.72
dh-clint Dog hepatocyte intrinsic clearance 5.458 uL/min/10^6 cells Moderate 0.72
dppb Dog plasma protein binding (% unbound) 31.970 % Moderate 0.72
fcs-ppb Fetal calf serum protein binding (% unbound) 51.780 % Moderate 0.72
herg hERG pIC50 4.354 pIC50 Moderate 0.72
hh-clint Human hepatocyte intrinsic clearance 4.656 uL/min/10^6 cells Moderate 0.72
hlm-clint Human liver microsomal intrinsic clearance 31.046 uL/min/mg protein Moderate 0.72
hppb Human plasma protein binding (% unbound) 21.750 % Moderate 0.72
kinase-safety-class ACVR2B,CDK5,EIF2AK3,GRK2,ITK,MAPK10,PDK1,PDK2,PDK4,PRKDC 10
kinase-selectivity-class GRK2,MAP2K6,MAP3K14 3
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 9.817 Moderate 0.73
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 15.560 Moderate 0.72
mh-clint Mouse hepatocyte intrinsic clearance 21.478 Moderate 0.72
mppb Mouse plasma protein binding (% unbound) 31.770 Moderate 0.72
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 31.405 Moderate 0.72
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 Moderate 0.73
pppb Pig plasma protein binding (% unbound) 40.950 % Moderate 0.72
rat-kpuu-brain Rat brain Kpuu 0.037 % Moderate 0.73
rh-clint Rat hepatocyte intrinsic clearance 31.989 uL/min/10^6 cells Moderate 0.72
rh-fuinc Rat hepatocyte fraction unbound in incubation 78.170 % Moderate 0.72
rppb Rat plasma protein binding (% unbound) 22.030 % Moderate 0.72
solubility-dd Solubility at pH 7.4 in DMSO 550.808 uM Moderate 0.72

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H02AB11 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids

Related Drugs by ATC class:

H02AB Glucocorticoids 15 drugs
betamethasonecloprednolcortivazoldeflazacortdexamethasonefluocortolonehydrocortisonemeprednisonemethylprednisoloneparamethasone acetateprednisoloneprednisone show all 15 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.38 acidic
pKa2 12.04 acidic
pKa3 13.69 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07230 KEGG_DRUG
C0044955 UMLSCUI
CHEBI:135572 CHEBI
CHEMBL2105359 ChEMBL_ID
DB13208 DRUGBANK_ID
C036266 MESH_SUPPLEMENTAL_RECORD_UI
20055008 PUBCHEM_CID
1457 INN_ID
IF8PQP966U UNII
12473 RXNORM
006604 NDDF

Pharmaceutical products:

None