dexamethasone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 824 50-02-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexamethasone
  • dexasone
  • dexmethsone
An anti-inflammatory 9-fluoro-glucocorticoid. The NIH COVID-19 Treatment Guidelines Panel recommends the use of dexamethasone in patients with COVID-19 who are receiving mechanical ventilation or in those who require supplemental oxygen but are not on me-chanical ventilation. It is not recommended the use of dexamethasone or other corticosteroids in nonhospitalized patients with mild to moderate COVID-19 or in hospitalized patients with COVID-19 who do not require supplemental oxygen.
  • Molecular weight: 392.47
  • Formula: C22H29FO5
  • CLOGP: 1.79
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.89
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 mg O
1.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.09 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2.60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.33 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.94 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.32 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 30, 1958 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 4921.91 10.28 3085 260303 41393 46381281
Neuropathy peripheral 1430.94 10.28 2137 261251 88756 46333918
Neutropenia 1291.97 10.28 2633 260755 140571 46282103
Febrile neutropenia 1120.33 10.28 1955 261433 92672 46330002
Rheumatoid arthritis 1032.40 10.28 87 263301 240128 46182546
Thrombocytopenia 863.48 10.28 2082 261306 124499 46298175
Completed suicide 757.56 10.28 13 263375 145907 46276767
Drug ineffective 687.88 10.28 1784 261604 676054 45746620
Pneumonia 506.32 10.28 3741 259647 372579 46050095
Diarrhoea 505.89 10.28 5091 258297 554511 45868163
Platelet count decreased 502.32 10.28 1469 261919 98555 46324119
Disease progression 491.57 10.28 1375 262013 89925 46332749
White blood cell count decreased 458.14 10.28 1534 261854 110697 46311977
Plasma cell myeloma recurrent 431.63 10.28 229 263159 2178 46420496
Drug hypersensitivity 415.50 10.28 458 262930 243367 46179307
Neutrophil count decreased 415.03 10.28 819 262569 42607 46380067
Constipation 389.38 10.28 1976 261412 172121 46250553
Pancytopenia 375.23 10.28 1194 262194 83864 46338810
Full blood count decreased 370.09 10.28 537 262851 21674 46401000
Injection site pain 353.28 10.28 85 263303 107067 46315607
Death 348.04 10.28 3146 260242 332402 46090272
Deep vein thrombosis 323.24 10.28 1088 262300 78685 46343989
Condition aggravated 319.53 10.28 558 262830 244494 46178180
Intentional overdose 310.23 10.28 13 263375 64931 46357743
Plasmacytoma 309.50 10.28 186 263202 2291 46420383
Psoriasis 302.77 10.28 42 263346 78562 46344112
Arthralgia 299.47 10.28 1055 262333 363548 46059126
Sepsis 295.67 10.28 1532 261856 134482 46288192
Drug abuse 283.18 10.28 19 263369 63389 46359285
Overdose 275.58 10.28 115 263273 101864 46320810
Contraindicated product administered 274.37 10.28 58 263330 79889 46342785
Systemic lupus erythematosus 270.44 10.28 27 263361 65153 46357521
Mucosal inflammation 260.76 10.28 637 262751 38339 46384335
Thrombosis 252.57 10.28 793 262595 55276 46367398
Anaemia 239.16 10.28 2347 261041 253432 46169242
Pain 236.41 10.28 1649 261739 475299 45947375
Leukopenia 235.53 10.28 884 262504 67459 46355215
Unevaluable event 222.80 10.28 669 262719 45506 46377168
Headache 220.14 10.28 1689 261699 476663 45946011
Suicide attempt 217.71 10.28 27 263361 55009 46367665
Therapeutic product effect decreased 215.46 10.28 98 263290 82503 46340171
Pemphigus 209.94 10.28 11 263377 45263 46377411
Malignant neoplasm progression 209.12 10.28 822 262566 64104 46358570
Febrile bone marrow aplasia 208.00 10.28 224 263164 6638 46416036
Pyrexia 206.76 10.28 2932 260456 345870 46076804
Injection site erythema 202.55 10.28 83 263305 74344 46348330
Tumour lysis syndrome 198.22 10.28 224 263164 7012 46415662
Plasma cell leukaemia 195.73 10.28 107 263281 1086 46421588
Cytopenia 186.97 10.28 225 263163 7543 46415131
Pulmonary embolism 181.77 10.28 1141 262247 107444 46315230
Laboratory test abnormal 180.89 10.28 399 262989 22448 46400226
Neutropenic sepsis 176.89 10.28 278 263110 12046 46410628
Abortion spontaneous 173.64 10.28 21 263367 43625 46379049
Dehydration 161.27 10.28 1489 261899 158051 46264623
Depression 160.41 10.28 462 262926 169642 46253032
Peripheral sensory neuropathy 158.50 10.28 191 263197 6412 46416262
Injection site reaction 155.60 10.28 39 263349 47810 46374864
Hand deformity 152.49 10.28 11 263377 34563 46388111
Multiple sclerosis relapse 152.02 10.28 27 263361 42098 46380576
Septic shock 151.43 10.28 688 262700 57205 46365469
Psoriatic arthropathy 151.07 10.28 15 263373 36364 46386310
Fatigue 146.50 10.28 4477 258911 604220 45818454
Bone marrow failure 143.22 10.28 430 262958 29239 46393435
Intentional product misuse 142.83 10.28 44 263344 47084 46375590
Abdominal discomfort 141.45 10.28 412 262976 150753 46271921
Flushing 138.95 10.28 726 262662 63888 46358786
Injection site pruritus 138.04 10.28 28 263360 39715 46382959
Therapeutic product effect incomplete 137.06 10.28 143 263245 78010 46344664
Metastases to central nervous system 136.59 10.28 235 263153 10986 46411688
Treatment failure 136.20 10.28 196 263192 92891 46329783
Musculoskeletal stiffness 135.96 10.28 214 263174 97779 46324895
Arthropathy 135.47 10.28 167 263221 84533 46338141
Suicidal ideation 134.84 10.28 75 263313 56307 46366367
Injection site swelling 134.80 10.28 31 263357 40296 46382378
Asthenia 128.39 10.28 2465 260923 308610 46114064
Synovitis 126.00 10.28 96 263292 60979 46361695
Venoocclusive liver disease 122.28 10.28 135 263253 4116 46418558
Wrong technique in product usage process 122.25 10.28 78 263310 54344 46368330
Haemophagocytic lymphohistiocytosis 120.86 10.28 189 263199 8153 46414521
Drug interaction 120.53 10.28 663 262725 202431 46220243
Posterior reversible encephalopathy syndrome 120.50 10.28 265 263123 14876 46407798
Osteonecrosis 120.40 10.28 369 263019 25375 46397299
Injection site bruising 119.90 10.28 27 263361 35609 46387065
Intentional self-injury 118.26 10.28 4 263384 24162 46398512
Inappropriate schedule of product administration 117.37 10.28 116 263272 64897 46357777
Joint swelling 114.67 10.28 514 262874 165559 46257115
Asthma 111.46 10.28 217 263171 91325 46331349
Pneumocystis jirovecii pneumonia 111.45 10.28 258 263130 14990 46407684
Endophthalmitis 106.43 10.28 111 263277 3167 46419507
Knee arthroplasty 105.90 10.28 7 263381 23658 46399016
Polyneuropathy 105.65 10.28 215 263173 11429 46411245
Hospitalisation 105.59 10.28 121 263267 63264 46359410
Light chain analysis increased 104.68 10.28 69 263319 1009 46421665
Acute lymphocytic leukaemia recurrent 104.54 10.28 90 263298 2005 46420669
Loss of personal independence in daily activities 103.25 10.28 102 263286 57081 46365593
Osteoarthritis 102.67 10.28 119 263269 61906 46360768
Myocardial infarction 101.61 10.28 252 263136 97276 46325398
Monoclonal immunoglobulin present 100.70 10.28 59 263329 691 46421983
Drug withdrawal syndrome 100.01 10.28 17 263371 27367 46395307
Maternal exposure during pregnancy 99.94 10.28 274 263114 102275 46320399
Migraine 98.95 10.28 151 263237 69875 46352799
Haematotoxicity 98.95 10.28 156 263232 6777 46415897
Stomatitis 96.93 10.28 689 262699 67608 46355066
Rheumatoid factor positive 94.76 10.28 5 263383 20456 46402218
Stress 94.18 10.28 91 263297 51460 46371214
Fall 93.20 10.28 1302 262086 327795 46094879
Bone pain 90.75 10.28 512 262876 46378 46376296
C-reactive protein abnormal 90.36 10.28 8 263380 21262 46401412
Decreased appetite 89.59 10.28 1564 261824 192272 46230402
Anti-cyclic citrullinated peptide antibody positive 84.69 10.28 6 263382 19139 46403535
Pregnancy 84.66 10.28 24 263364 27113 46395561
Pulmonary arterial hypertension 84.55 10.28 21 263367 25907 46396767
Neurotoxicity 84.17 10.28 217 263171 13500 46409174
Mobility decreased 83.38 10.28 133 263255 60461 46362213
Hyperglycaemia 81.63 10.28 403 262985 34668 46388006
Drug intolerance 81.29 10.28 491 262897 146558 46276116
Pain in extremity 79.14 10.28 1007 262381 257673 46165001
Hypoglycaemia 78.91 10.28 115 263273 54234 46368440
Anaphylactic shock 76.33 10.28 270 263118 20004 46402670
Palmar-plantar erythrodysaesthesia syndrome 74.98 10.28 270 263118 20181 46402493
Glossodynia 74.66 10.28 84 263304 44289 46378385
Acute lymphocytic leukaemia 74.52 10.28 85 263303 2688 46419986
Arthritis 74.26 10.28 208 263180 77108 46345566
Diffuse large B-cell lymphoma recurrent 74.25 10.28 64 263324 1428 46421246
Coronary artery disease 73.60 10.28 50 263338 33702 46388972
Multiple sclerosis 73.59 10.28 24 263364 24767 46397907
Hepatic enzyme increased 73.50 10.28 227 263161 81560 46341114
Erythema 71.65 10.28 1168 262220 141652 46281022
Brain oedema 71.07 10.28 192 263196 12286 46410388
Corneal oedema 70.77 10.28 65 263323 1581 46421093
Haemoglobin decreased 70.53 10.28 1070 262318 127879 46294795
Exposure during pregnancy 70.46 10.28 342 263046 107870 46314804
Ageusia 69.89 10.28 181 263207 11291 46411383
Product quality issue 69.80 10.28 59 263329 35589 46387085
Gait disturbance 69.73 10.28 506 262882 144757 46277917
Surgery 69.23 10.28 38 263350 28747 46393927
Blood potassium decreased 68.68 10.28 408 262980 37655 46385019
Myelodysplastic syndrome 68.67 10.28 220 263168 15491 46407183
Pneumonitis 68.59 10.28 330 263058 28090 46394584
Adverse drug reaction 67.92 10.28 456 262932 43906 46378768
Hip arthroplasty 66.68 10.28 11 263377 18101 46404573
Poisoning 66.15 10.28 3 263385 13991 46408683
Swelling 66.07 10.28 421 262967 124090 46298584
Incorrect dose administered 65.52 10.28 97 263291 45453 46377221
Cardiac amyloidosis 65.26 10.28 39 263349 475 46422199
Anxiety 64.26 10.28 686 262702 181271 46241403
Injury 63.09 10.28 94 263294 43933 46378741
Accidental exposure to product 61.54 10.28 21 263367 21060 46401614
Dysgeusia 61.27 10.28 415 262973 40076 46382598
Osteolysis 60.16 10.28 74 263314 2538 46420136
Device issue 59.91 10.28 19 263369 19961 46402713
Injection site haemorrhage 59.81 10.28 21 263367 20688 46401986
Sopor 59.20 10.28 19 263369 19809 46402865
Taste disorder 58.71 10.28 113 263275 5765 46416909
Injection site rash 57.34 10.28 10 263378 15803 46406871
Sinusitis 56.64 10.28 464 262924 129304 46293370
Large intestine perforation 56.21 10.28 129 263259 7451 46415223
Product substitution issue 55.62 10.28 9 263379 15022 46407652
Coma 55.27 10.28 158 263230 58191 46364483
Bone lesion 54.50 10.28 99 263289 4832 46417842
Pericarditis 54.13 10.28 34 263354 23893 46398781
Red blood cell sedimentation rate increased 53.92 10.28 31 263357 22858 46399816
Sleep apnoea syndrome 53.84 10.28 29 263359 22172 46400502
Protein total increased 53.23 10.28 68 263320 2425 46420249
Right ventricular failure 52.54 10.28 13 263375 16080 46406594
Chronic obstructive pulmonary disease 52.46 10.28 159 263229 57474 46365200
Respiratory syncytial virus infection 52.08 10.28 96 263292 4739 46417935
Gastrointestinal perforation 52.07 10.28 77 263311 3160 46419514
Back pain 52.00 10.28 1552 261836 208487 46214187
Herpes simplex encephalitis 51.83 10.28 28 263360 277 46422397
Withdrawal syndrome 51.33 10.28 19 263369 18115 46404559
Fibromyalgia 51.14 10.28 79 263309 36384 46386290
Somnolence 50.56 10.28 602 262786 155919 46266755
Influenza like illness 50.16 10.28 162 263226 57408 46365266
No adverse event 50.11 10.28 72 263316 34159 46388515
Injection site urticaria 49.51 10.28 5 263383 11962 46410712
Injection site mass 49.39 10.28 12 263376 15028 46407646
Injection site warmth 49.31 10.28 9 263379 13763 46408911
Lactic acidosis 48.97 10.28 72 263316 33837 46388837
Pulmonary thrombosis 48.44 10.28 120 263268 7282 46415392
Wound 48.24 10.28 106 263282 42696 46379978
Corneal decompensation 47.99 10.28 14 263374 16 46422658
Joint range of motion decreased 47.88 10.28 13 263375 15111 46407563
Multiple allergies 47.71 10.28 119 263269 7252 46415422
Hyperviscosity syndrome 47.69 10.28 23 263365 175 46422499
Pneumonia influenzal 47.04 10.28 50 263338 1459 46421215
Pathological fracture 46.96 10.28 124 263264 7826 46414848
Therapy partial responder 46.75 10.28 90 263298 4592 46418082
Colitis ulcerative 46.27 10.28 21 263367 17711 46404963
Rhabdomyolysis 45.43 10.28 106 263282 41803 46380871
Osteoporosis 45.41 10.28 101 263287 40507 46382167
Underdose 45.35 10.28 27 263361 19531 46403143
Clostridium difficile colitis 45.18 10.28 216 263172 18337 46404337
Palpitations 45.11 10.28 333 263055 94926 46327748
Neuroleptic malignant syndrome 45.11 10.28 5 263383 11117 46411557
Myalgia 45.08 10.28 460 262928 122628 46300046
Human chorionic gonadotropin increased 44.30 10.28 44 263344 1183 46421491
Laryngospasm 44.30 10.28 67 263321 2806 46419868
Hypercalcaemia 44.19 10.28 235 263153 20811 46401863
Amyloidosis 44.16 10.28 42 263346 1069 46421605
Blood pressure fluctuation 43.63 10.28 65 263323 30383 46392291
COVID-19 pneumonia 43.06 10.28 71 263317 3204 46419470
Peripheral motor neuropathy 42.67 10.28 47 263341 1429 46421245
Iron deficiency anaemia 42.43 10.28 22 263366 17184 46405490
Cataract 42.37 10.28 417 262971 44998 46377676
Muscle spasticity 42.00 10.28 7 263381 11433 46411241
Disseminated intravascular coagulation 41.83 10.28 215 263173 18790 46403884
Multiple organ dysfunction syndrome 41.72 10.28 461 262927 51249 46371425
Impaired work ability 41.65 10.28 10 263378 12626 46410048
Bacteraemia 41.23 10.28 174 263214 14005 46408669
Infective pulmonary exacerbation of cystic fibrosis 41.06 10.28 6 263382 10801 46411873
Product complaint 41.04 10.28 9 263379 12092 46410582
Hypoxia 40.85 10.28 460 262928 51378 46371296
Neutrophil count abnormal 40.45 10.28 59 263329 2391 46420283
International normalised ratio increased 40.10 10.28 133 263255 46750 46375924
Obesity 40.02 10.28 15 263373 14191 46408483
Bronchospasm 39.80 10.28 185 263203 15522 46407152
Joint stiffness 39.70 10.28 57 263331 27051 46395623
Neutropenic infection 39.60 10.28 40 263348 1098 46421576
Rash 39.28 10.28 2420 260968 354092 46068582
Off label use 39.05 10.28 2563 260825 377278 46045396
Ejection fraction decreased 38.84 10.28 202 263186 17735 46404939
Dyspnoea 38.72 10.28 3393 259995 512155 45910519
Intestinal perforation 38.71 10.28 142 263246 10709 46411965
Treatment noncompliance 38.36 10.28 68 263320 29663 46393011
Hepatitis B reactivation 38.32 10.28 45 263343 1469 46421205
Carpal tunnel syndrome 38.04 10.28 21 263367 15838 46406836
Colitis 37.86 10.28 349 263039 36998 46385676
Device breakage 37.72 10.28 5 263383 9687 46412987
Emotional distress 37.17 10.28 73 263315 30634 46392040
Sedation 36.79 10.28 45 263343 22865 46399809
Ileus 36.64 10.28 167 263221 13897 46408777
Adrenogenital syndrome 36.58 10.28 13 263375 39 46422635
Glioblastoma multiforme 36.52 10.28 34 263354 842 46421832
Cytomegalovirus infection 36.34 10.28 200 263188 17944 46404730
Nephrolithiasis 36.30 10.28 83 263305 32968 46389706
Product storage error 35.74 10.28 11 263377 11781 46410893
Hypokalaemia 35.62 10.28 696 262692 87328 46335346
Crying 35.58 10.28 40 263348 21101 46401573
Nasal congestion 35.55 10.28 145 263243 47968 46374706
Depressed mood 35.53 10.28 85 263303 33234 46389440
Discomfort 35.53 10.28 139 263249 46531 46376143
Squamous cell carcinoma of skin 35.34 10.28 85 263303 5062 46417612
Medication error 35.29 10.28 76 263312 30835 46391839
Accidental overdose 34.84 10.28 37 263351 20029 46402645
Peritonitis bacterial 34.81 10.28 4 263384 8649 46414025
Intentional product use issue 34.80 10.28 166 263222 52614 46370060
Foot deformity 34.78 10.28 22 263366 15403 46407271
Product prescribing error 34.77 10.28 37 263351 20010 46402664
Febrile infection 34.42 10.28 39 263349 1224 46421450
Feeling hot 34.29 10.28 346 263042 37582 46385092
Primary amyloidosis 34.27 10.28 12 263376 34 46422640
Venous thrombosis 34.17 10.28 80 263308 4682 46417992
Corneal disorder 34.09 10.28 45 263343 1658 46421016
COVID-19 34.08 10.28 200 263188 18375 46404299
Full blood count increased 33.66 10.28 33 263355 873 46421801
Respiratory failure 33.54 10.28 735 262653 94081 46328593
Spinal cord compression 33.39 10.28 68 263320 3616 46419058
Systemic candida 33.04 10.28 57 263331 2670 46420004
Dry skin 32.78 10.28 365 263023 40651 46382023
Vomiting 32.73 10.28 2972 260416 449822 45972852
Fear 32.61 10.28 26 263362 16146 46406528
Glioblastoma 32.47 10.28 31 263357 793 46421881
Hallucination 32.41 10.28 158 263230 49793 46372881
Panic attack 32.25 10.28 40 263348 20202 46402472
Hypocalcaemia 32.23 10.28 260 263128 26525 46396149
Embolism 32.15 10.28 101 263287 7037 46415637
Bone erosion 32.07 10.28 7 263381 9436 46413238
Blood lactate dehydrogenase abnormal 31.96 10.28 20 263368 266 46422408
Paraesthesia 31.84 10.28 878 262510 116559 46306115
Bursitis 31.83 10.28 39 263349 19803 46402871
Hypertriglyceridaemia 31.71 10.28 87 263301 5617 46417057
Body height decreased 31.69 10.28 123 263265 9529 46413145
Device malfunction 31.66 10.28 18 263370 13356 46409318
Red blood cell count decreased 31.63 10.28 302 263086 32321 46390353
Joint effusion 31.62 10.28 14 263374 11981 46410693
Keratitis fungal 31.57 10.28 15 263373 110 46422564
Tenosynovitis 31.46 10.28 3 263385 7512 46415162
Blood pressure increased 31.32 10.28 514 262874 126152 46296522
Pseudomonal sepsis 31.31 10.28 47 263341 1955 46420719
Intraocular pressure increased 31.29 10.28 89 263299 5868 46416806
Escherichia bacteraemia 31.24 10.28 56 263332 2705 46419969
Lacrimation increased 31.21 10.28 174 263214 15687 46406987
Strongyloidiasis 31.20 10.28 31 263357 834 46421840
Gastrooesophageal reflux disease 30.99 10.28 269 263119 74075 46348599
Haemoglobin abnormal 30.98 10.28 73 263315 4290 46418384
Femur fracture 30.92 10.28 106 263282 36891 46385783
Lymphopenia 30.91 10.28 169 263219 15124 46407550
Foot fracture 30.88 10.28 39 263349 19543 46403131
Cytokine release syndrome 30.79 10.28 91 263297 6132 46416542
Substance-induced psychotic disorder 30.68 10.28 41 263347 1529 46421145
Aspergillus infection 30.58 10.28 97 263291 6793 46415881
Neoplasm progression 30.49 10.28 256 263132 26427 46396247
Product use in unapproved indication 30.43 10.28 695 262693 89578 46333096
Hiatus hernia 30.40 10.28 35 263353 18267 46404407
Sleep disorder 30.37 10.28 148 263240 46647 46376027
Pleural effusion 30.29 10.28 646 262742 82306 46340368
Nausea 30.26 10.28 4369 259019 683085 45739589
Diffuse large B-cell lymphoma refractory 30.15 10.28 32 263356 932 46421742
Tooth disorder 30.13 10.28 230 263158 23073 46399601
Refractory cytopenia with multilineage dysplasia 29.75 10.28 15 263373 127 46422547
Cholelithiasis 29.58 10.28 115 263273 38566 46384108
Eosinophilia 29.55 10.28 39 263349 19178 46403496
Rhinovirus infection 29.34 10.28 64 263324 3572 46419102
Acute interstitial pneumonitis 29.19 10.28 27 263361 663 46422011
Therapeutic response unexpected 29.18 10.28 27 263361 15589 46407085
Musculoskeletal pain 29.11 10.28 254 263134 69874 46352800
Hypofibrinogenaemia 29.09 10.28 33 263355 1037 46421637
Cardiopulmonary failure 28.95 10.28 64 263324 3605 46419069
Jugular vein thrombosis 28.74 10.28 53 263335 2617 46420057
Hyperkalaemia 28.68 10.28 168 263220 50541 46372133
Hyperaemia 28.67 10.28 45 263343 1947 46420727
Human bocavirus infection 28.54 10.28 20 263368 325 46422349
Corneal opacity 28.46 10.28 27 263361 685 46421989
Blood pressure diastolic decreased 28.46 10.28 23 263365 14188 46408486
Hepatic cirrhosis 28.46 10.28 28 263360 15704 46406970
Coombs indirect test positive 28.39 10.28 10 263378 29 46422645
Nightmare 28.38 10.28 31 263357 16567 46406107
Lupus-like syndrome 28.35 10.28 5 263383 7839 46414835
Cholecystectomy 28.20 10.28 8 263380 9034 46413640
Malaise 28.13 10.28 1555 261833 329677 46092997
Hypothyroidism 28.12 10.28 87 263301 31251 46391423
Hypercholesterolaemia 28.05 10.28 15 263373 11515 46411159
Gastrointestinal fungal infection 27.98 10.28 18 263370 252 46422422
Heart block congenital 27.97 10.28 8 263380 8 46422666
Oral candidiasis 27.91 10.28 182 263206 17350 46405324
Prescribed overdose 27.85 10.28 12 263376 10437 46412237
Injection site phlebitis 27.62 10.28 14 263374 120 46422554
Cardiotoxicity 27.46 10.28 92 263296 6630 46416044
Performance status decreased 27.29 10.28 58 263330 3179 46419495
Body dysmorphic disorder 27.29 10.28 15 263373 154 46422520
Blood culture positive 27.29 10.28 71 263317 4441 46418233
White blood cell count abnormal 27.27 10.28 77 263311 5055 46417619
General physical health deterioration 27.14 10.28 850 262538 114919 46307755
Electrocardiogram QT prolonged 26.97 10.28 174 263214 51151 46371523
Lung infiltration 26.93 10.28 153 263235 13890 46408784
Parkinsonism 26.78 10.28 6 263382 7942 46414732
Light chain analysis abnormal 26.76 10.28 14 263374 129 46422545
Pneumatosis intestinalis 26.76 10.28 44 263344 1981 46420693
Seasonal allergy 26.72 10.28 147 263241 13187 46409487
Aplasia 26.67 10.28 61 263327 3515 46419159
Mitochondrial DNULL mutation 26.67 10.28 17 263371 234 46422440
Labelled drug-drug interaction medication error 26.49 10.28 9 263379 9052 46413622
Road traffic accident 26.42 10.28 59 263329 23632 46399042
Inflammation 26.34 10.28 164 263224 48617 46374057
Osteonecrosis of jaw 26.08 10.28 303 263085 34099 46388575
Corneal perforation 25.78 10.28 22 263366 484 46422190
Blood pressure systolic increased 25.77 10.28 80 263308 28707 46393967
Enterocolitis 25.72 10.28 85 263303 6083 46416591
Pneumonia fungal 25.71 10.28 66 263322 4094 46418580
Wheezing 25.56 10.28 186 263202 53200 46369474
Haematoma 25.51 10.28 93 263295 31779 46390895
Injection site induration 25.47 10.28 7 263381 8072 46414602
Parainfluenzae virus infection 25.26 10.28 40 263348 1744 46420930
Glycosylated haemoglobin increased 25.23 10.28 15 263373 10861 46411813
Pneumonia cytomegaloviral 25.11 10.28 42 263346 1918 46420756
Botryomycosis 25.10 10.28 6 263382 0 46422674
Tardive dyskinesia 24.80 10.28 6 263382 7537 46415137
Prescribed underdose 24.78 10.28 19 263369 12034 46410640
Product use issue 24.75 10.28 380 263008 94264 46328410
Crossmatch incompatible 24.62 10.28 9 263379 30 46422644
Dermatitis acneiform 24.57 10.28 64 263324 4006 46418668
Propofol infusion syndrome 24.56 10.28 26 263362 755 46421919
Radiation skin injury 24.28 10.28 27 263361 830 46421844
Neoplasm recurrence 24.17 10.28 46 263342 2327 46420347
Hysterectomy 24.17 10.28 7 263381 7799 46414875
Extrapyramidal disorder 24.15 10.28 17 263371 11251 46411423
Genital haemorrhage 24.14 10.28 4 263384 6562 46416112
Abnormal dreams 24.10 10.28 14 263374 10265 46412409
Hordeolum 24.08 10.28 44 263344 2157 46420517
Amenorrhoea 24.06 10.28 10 263378 8885 46413789
Product dispensing error 23.99 10.28 11 263377 9222 46413452
Mood swings 23.97 10.28 34 263354 16218 46406456
Pseudocellulitis 23.84 10.28 8 263380 19 46422655
Stridor 23.82 10.28 54 263334 3093 46419581
Cerebrovascular accident 23.67 10.28 414 262974 100625 46322049
Urticaria 23.65 10.28 496 262892 117396 46305278
Hyperbilirubinaemia 23.61 10.28 119 263269 10319 46412355
Helicobacter infection 23.50 10.28 19 263369 11717 46410957
Weight increased 23.35 10.28 728 262660 163745 46258929
Ovarian cyst 23.33 10.28 27 263361 14060 46408614
Perineal necrosis 23.27 10.28 12 263376 107 46422567
Phaeochromocytoma crisis 23.18 10.28 14 263374 174 46422500
Drug level increased 23.05 10.28 43 263345 18398 46404276
Poor venous access 23.02 10.28 9 263379 8299 46414375
Mesenteric abscess 23.00 10.28 11 263377 82 46422592
Vitreous haemorrhage 22.94 10.28 39 263349 1805 46420869
Salmonella sepsis 22.83 10.28 15 263373 218 46422456
Computerised tomogram thorax abnormal 22.80 10.28 33 263355 1328 46421346
Candida infection 22.62 10.28 208 263180 22032 46400642
Platelet count abnormal 22.60 10.28 49 263339 2723 46419951
Ocular hypertension 22.46 10.28 25 263363 769 46421905
Haematemesis 22.44 10.28 85 263303 28721 46393953
Vasogenic cerebral oedema 22.41 10.28 20 263368 468 46422206
Intervertebral disc degeneration 22.38 10.28 25 263363 13227 46409447
Brain abscess 22.31 10.28 37 263351 1678 46420996
Cholecystitis chronic 22.29 10.28 16 263372 10483 46412191
Pre-existing condition improved 22.26 10.28 5 263383 6607 46416067
Coronary artery occlusion 22.09 10.28 9 263379 8093 46414581
Hypopyon 22.03 10.28 25 263363 786 46421888
Vein discolouration 21.99 10.28 13 263375 155 46422519
Perineal infection 21.85 10.28 12 263376 123 46422551
Large intestinal ulcer perforation 21.80 10.28 10 263378 67 46422607
Philadelphia chromosome positive 21.68 10.28 16 263372 283 46422391
Venous thrombosis limb 21.53 10.28 49 263339 2814 46419860
Fusarium infection 21.37 10.28 21 263367 557 46422117
Recall phenomenon 21.37 10.28 21 263367 557 46422117
Therapeutic response decreased 21.30 10.28 149 263239 42996 46379678
Aggression 21.23 10.28 62 263326 22682 46399992
Grip strength decreased 21.22 10.28 11 263377 8595 46414079
Bipolar disorder 21.21 10.28 7 263381 7170 46415504
Leukoencephalopathy 21.20 10.28 60 263328 3944 46418730
Blood immunoglobulin G increased 21.16 10.28 30 263358 1184 46421490
Blood pressure systolic abnormal 21.11 10.28 3 263385 5514 46417160
Renal failure 21.11 10.28 812 262576 112782 46309892
Device failure 21.11 10.28 4 263384 5955 46416719
Irritable bowel syndrome 21.10 10.28 38 263350 16477 46406197
Procedural pain 21.04 10.28 26 263362 13153 46409521
Cryptococcosis 21.03 10.28 25 263363 827 46421847
Pulmonary hypertension 21.02 10.28 118 263270 35875 46386799
Cytomegalovirus infection reactivation 20.84 10.28 33 263355 1439 46421235
Atrial fibrillation 20.82 10.28 747 262641 102843 46319831
Pneumonia pneumococcal 20.73 10.28 37 263351 1781 46420893
Retinal pigment epitheliopathy 20.60 10.28 14 263374 216 46422458
Product packaging confusion 20.60 10.28 12 263376 139 46422535
Vascular pain 20.58 10.28 22 263366 646 46422028
Gastroenteritis norovirus 20.54 10.28 34 263354 1539 46421135
Ulcer 20.49 10.28 42 263346 17350 46405324
Therapy cessation 20.47 10.28 79 263309 26550 46396124
Failure to thrive 20.33 10.28 83 263305 6581 46416093
Subclavian vein thrombosis 20.32 10.28 37 263351 1809 46420865
Pseudomonas test positive 20.27 10.28 23 263365 723 46421951
Eczema 20.23 10.28 54 263334 20346 46402328
Nasal abscess 20.23 10.28 12 263376 144 46422530
Stem cell transplant 20.21 10.28 36 263352 1730 46420944
Shock 20.09 10.28 200 263188 21645 46401029
Clostridium bacteraemia 20.08 10.28 13 263375 184 46422490
Tuberculosis 20.08 10.28 17 263371 10248 46412426
Scar 19.94 10.28 23 263365 11996 46410678
Malignant neoplasm of unknown primary site 19.92 10.28 15 263373 274 46422400
Protein urine 19.91 10.28 21 263367 607 46422067
Blood immunoglobulin A increased 19.85 10.28 17 263371 376 46422298
Incorrect product administration duration 19.81 10.28 15 263373 9562 46413112
Escherichia test positive 19.80 10.28 38 263350 1934 46420740
Cardio-respiratory arrest 19.79 10.28 229 263159 59640 46363034
Dizziness 19.70 10.28 1653 261735 338761 46083913
Differentiation syndrome 19.69 10.28 25 263363 886 46421788
Antithrombin III decreased 19.64 10.28 15 263373 280 46422394
Cancer pain 19.63 10.28 43 263345 2407 46420267
Adrenal insufficiency 19.54 10.28 134 263254 12990 46409684
Superficial spreading melanoma stage unspecified 19.52 10.28 11 263377 119 46422555
Hypothermia 19.48 10.28 24 263364 12159 46410515
Amnesia 19.47 10.28 146 263242 41485 46381189
Enterococcal bacteraemia 19.43 10.28 29 263359 1200 46421474
Iridocyclitis 19.43 10.28 38 263350 1962 46420712
Central nervous system leukaemia 19.41 10.28 10 263378 89 46422585
Crohn's disease 19.32 10.28 7 263381 6764 46415910
Cerebral aspergillosis 19.29 10.28 16 263372 338 46422336
Hypertransaminasaemia 19.19 10.28 53 263335 3435 46419239
Listeriosis 19.08 10.28 28 263360 1141 46421533
Pulmonary haemorrhage 19.05 10.28 80 263308 6425 46416249
Spinal operation 19.03 10.28 4 263384 5536 46417138
Angina pectoris 18.97 10.28 82 263306 26693 46395981
Skin discolouration 18.94 10.28 274 263114 32406 46390268
Cytomegalovirus chorioretinitis 18.92 10.28 32 263356 1475 46421199
Vitamin D deficiency 18.81 10.28 21 263367 11113 46411561
Miosis 18.80 10.28 7 263381 6650 46416024
Hypoaesthesia 18.51 10.28 834 262554 118035 46304639
Ill-defined disorder 18.50 10.28 83 263305 26744 46395930
Hallucination, auditory 18.49 10.28 20 263368 10736 46411938
Lip swelling 18.47 10.28 77 263311 25318 46397356
Respiratory tract infection 18.46 10.28 254 263134 29718 46392956
Myelopathy 18.45 10.28 43 263345 2509 46420165
Complication associated with device 18.44 10.28 37 263351 15404 46407270
Infection 18.41 10.28 926 262462 132666 46290008
Torsade de pointes 18.35 10.28 25 263363 12129 46410545
Oral disorder 18.28 10.28 90 263298 7732 46414942
Breast cancer metastatic 18.24 10.28 136 263252 13542 46409132
Peripheral sensorimotor neuropathy 18.21 10.28 28 263360 1190 46421484
Hypotony of eye 18.20 10.28 11 263377 137 46422537
Anaphylactoid reaction 18.18 10.28 52 263336 3439 46419235
Cytomegalovirus colitis 18.13 10.28 34 263354 1701 46420973
Neck pain 18.11 10.28 212 263176 55094 46367580
Mucormycosis 18.10 10.28 40 263348 2252 46420422
Ulcerative keratitis 18.09 10.28 40 263348 2253 46420421
Bone density decreased 18.06 10.28 17 263371 9735 46412939
Eosinophil count increased 18.04 10.28 11 263377 7855 46414819
Application site erythema 18.00 10.28 3 263385 4901 46417773
Virilism 17.98 10.28 7 263381 29 46422645
Dyskinesia 17.90 10.28 93 263295 28832 46393842
Abnormal behaviour 17.82 10.28 60 263328 20998 46401676
Blood creatine phosphokinase increased 17.81 10.28 88 263300 27636 46395038
Haematochezia 17.77 10.28 131 263257 37362 46385312
Corneal thinning 17.76 10.28 10 263378 108 46422566
Diverticular perforation 17.72 10.28 50 263338 3281 46419393
Hemiparesis 17.62 10.28 182 263206 19887 46402787
Alopecia 17.59 10.28 743 262645 161671 46261003
Compression fracture 17.58 10.28 76 263312 6181 46416493
Necrotising retinitis 17.56 10.28 14 263374 279 46422395
Chalazion 17.52 10.28 14 263374 280 46422394
Bacterial sepsis 17.49 10.28 52 263336 3515 46419159
Transplant rejection 17.45 10.28 17 263371 9579 46413095
Nail dystrophy 17.39 10.28 17 263371 448 46422226
Respiratory depression 17.37 10.28 24 263364 11576 46411098
Mantle cell lymphoma recurrent 17.30 10.28 10 263378 114 46422560
Target skin lesion 17.29 10.28 9 263379 82 46422592
Serotonin syndrome 17.27 10.28 74 263314 24146 46398528
Caesarean section 17.20 10.28 43 263345 16560 46406114
Pneumonia aspiration 17.19 10.28 106 263282 31499 46391175
Myopathy 17.19 10.28 97 263291 8784 46413890
Muscle spasms 17.09 10.28 854 262534 122259 46300415
Chorioretinopathy 17.08 10.28 21 263367 720 46421954
Mucocutaneous ulceration 17.04 10.28 11 263377 155 46422519
Catabolic state 17.03 10.28 8 263380 57 46422617
Mental disorder 16.93 10.28 67 263321 22358 46400316
Enthesopathy 16.93 10.28 3 263385 4687 46417987
Anhedonia 16.91 10.28 20 263368 10315 46412359
Food allergy 16.89 10.28 9 263379 6924 46415750
Transplant dysfunction 16.89 10.28 3 263385 4679 46417995
Metastases to meninges 16.80 10.28 35 263353 1892 46420782
Device use error 16.79 10.28 4 263384 5077 46417597
Pneumonia viral 16.77 10.28 78 263310 6546 46416128
Corneal infiltrates 16.68 10.28 11 263377 161 46422513
Bone marrow infiltration 16.67 10.28 16 263372 412 46422262
Menstruation irregular 16.66 10.28 8 263380 6531 46416143
Drug dependence 16.64 10.28 57 263331 19844 46402830
Ileus paralytic 16.64 10.28 58 263330 4265 46418409
Abortion induced 16.63 10.28 20 263368 10240 46412434
Lymphoedema 16.63 10.28 94 263294 8518 46414156
Respiratory arrest 16.58 10.28 117 263271 33699 46388975
Plasma cell myeloma refractory 16.58 10.28 5 263383 7 46422667
Somnambulism 16.58 10.28 4 263384 5033 46417641
Post procedural infection 16.55 10.28 11 263377 7502 46415172
Streptococcal bacteraemia 16.55 10.28 28 263360 1291 46421383
Chronic kidney disease 16.53 10.28 149 263239 40722 46381952
Adenocarcinoma of colon 16.51 10.28 37 263351 2103 46420571
Swelling face 16.49 10.28 404 262984 52655 46370019
Refractory anaemia with an excess of blasts 16.45 10.28 16 263372 419 46422255
Escherichia sepsis 16.43 10.28 57 263331 4181 46418493
Meningoencephalitis herpetic 16.42 10.28 25 263363 1053 46421621
Movement disorder 16.41 10.28 45 263343 16804 46405870
Contusion 16.41 10.28 372 263016 87115 46335559
Device leakage 16.27 10.28 5 263383 5360 46417314
Myelosuppression 16.16 10.28 86 263302 7617 46415057
Product administration error 16.03 10.28 57 263331 19624 46403050
Hypogammaglobulinaemia 16.02 10.28 67 263321 5371 46417303
Spinal fracture 16.00 10.28 144 263244 15161 46407513
Spinal osteoarthritis 15.98 10.28 35 263353 14116 46408558
Electrolyte imbalance 15.98 10.28 158 263230 17068 46405606
Bronchopulmonary aspergillosis 15.94 10.28 84 263304 7412 46415262
Pre-eclampsia 15.93 10.28 13 263375 7981 46414693
Joint dislocation 15.91 10.28 24 263364 11162 46411512
Vitritis 15.89 10.28 22 263366 849 46421825
Refractory anaemia with ringed sideroblasts 15.82 10.28 5 263383 9 46422665
Atrial septal defect 15.75 10.28 8 263380 6324 46416350
Muscle injury 15.75 10.28 4 263384 4862 46417812
Breast cancer female 15.65 10.28 7 263381 5956 46416718
Mucosal infection 15.61 10.28 9 263379 102 46422572
Skin exfoliation 15.61 10.28 267 263121 32671 46390003
Exostosis 15.61 10.28 21 263367 10242 46412432
Respiratory distress 15.59 10.28 260 263128 31656 46391018
Disturbance in attention 15.57 10.28 109 263279 31451 46391223
Human chorionic gonadotropin positive 15.50 10.28 7 263381 45 46422629
Neutropenic colitis 15.47 10.28 37 263351 2195 46420479
Pain in jaw 15.47 10.28 140 263248 38232 46384442
Oesophageal squamous cell carcinoma 15.46 10.28 9 263379 104 46422570
Pulse waveform abnormal 15.45 10.28 8 263380 72 46422602
Drug level decreased 15.43 10.28 7 263381 5905 46416769
Gastrointestinal haemorrhage 15.37 10.28 326 263062 77047 46345627
Ankle brachial index decreased 15.36 10.28 8 263380 73 46422601
Infusion site streaking 15.29 10.28 14 263374 339 46422335
Adenocarcinoma pancreas 15.28 10.28 25 263363 1121 46421553
B precursor type acute leukaemia 15.28 10.28 11 263377 187 46422487
Colitis microscopic 15.27 10.28 9 263379 6547 46416127
Polyp 15.22 10.28 5 263383 5138 46417536
Scoliosis 15.22 10.28 8 263380 6202 46416472
Polyarthritis 15.21 10.28 9 263379 6533 46416141
Paraproteinaemia 15.18 10.28 10 263378 146 46422528
Tooth erosion 15.16 10.28 16 263372 463 46422211
Soft tissue disorder 15.12 10.28 55 263333 4131 46418543
Plasmablastic lymphoma 15.10 10.28 12 263376 238 46422436
Tuberculoma of central nervous system 15.08 10.28 13 263375 290 46422384
Hallucination, visual 15.07 10.28 51 263337 17822 46404852
Lymphorrhoea 15.00 10.28 7 263381 49 46422625
Abdominal pain lower 14.92 10.28 65 263323 21116 46401558
Atelectasis 14.91 10.28 167 263221 18623 46404051
Carotid intima-media thickness increased 14.91 10.28 8 263380 78 46422596
Immune-mediated encephalitis 14.89 10.28 7 263381 50 46422624
Spinal compression fracture 14.85 10.28 124 263264 12779 46409895
Klebsiella bacteraemia 14.80 10.28 25 263363 1151 46421523
Non-small cell lung cancer metastatic 14.78 10.28 18 263370 611 46422063
Chemotherapy 14.76 10.28 27 263361 1325 46421349
Hyperamylasaemia 14.73 10.28 14 263374 356 46422318
Brain stem glioma 14.65 10.28 8 263380 81 46422593
Adjusted calcium increased 14.59 10.28 5 263383 13 46422661
Blood gases abnormal 14.57 10.28 18 263370 620 46422054
Pupillary deformity 14.51 10.28 4 263384 3 46422671
Meningitis cryptococcal 14.51 10.28 25 263363 1170 46421504
Birdshot chorioretinopathy 14.48 10.28 8 263380 83 46422591
Infusion site swelling 14.48 10.28 7 263381 5692 46416982
Intraocular pressure decreased 14.43 10.28 9 263379 119 46422555
Polychromasia 14.40 10.28 8 263380 84 46422590
Asphyxia 14.38 10.28 6 263382 5320 46417354
Diffuse large B-cell lymphoma 14.36 10.28 69 263319 5869 46416805
Vertebral column mass 14.35 10.28 10 263378 161 46422513
Chronic myelomonocytic leukaemia 14.33 10.28 13 263375 311 46422363
Eye abscess 14.32 10.28 8 263380 85 46422589
Hypogeusia 14.30 10.28 23 263365 1016 46421658
Sense of oppression 14.30 10.28 23 263365 1016 46421658
Iris adhesions 14.23 10.28 13 263375 314 46422360
Therapy non-responder 14.22 10.28 318 263070 40834 46381840
Spinal stenosis 14.18 10.28 31 263357 12512 46410162
Loss of consciousness 14.18 10.28 484 262904 107754 46314920
Angina unstable 14.16 10.28 13 263375 7535 46415139
Chills 14.13 10.28 670 262718 95362 46327312
Hepatitis 14.12 10.28 115 263273 32100 46390574
Joint injury 14.12 10.28 58 263330 19151 46403523
Acne 14.11 10.28 61 263327 19858 46402816
Monoclonal immunoglobulin increased 14.08 10.28 8 263380 88 46422586
Frustration tolerance decreased 14.07 10.28 6 263382 5251 46417423
Renal replacement therapy 14.06 10.28 6 263382 33 46422641
Cardiac failure congestive 14.03 10.28 402 262986 91348 46331326
Cauda equina syndrome 14.02 10.28 18 263370 645 46422029
Tendonitis 14.00 10.28 38 263350 14239 46408435
Urethral cancer 13.98 10.28 4 263384 4 46422670
Cataract traumatic 13.98 10.28 4 263384 4 46422670
Blood glucose decreased 13.91 10.28 57 263331 18835 46403839
Maternal exposure before pregnancy 13.91 10.28 4 263384 4477 46418197
Emphysematous cystitis 13.87 10.28 9 263379 128 46422546
Enterobacter infection 13.87 10.28 32 263356 1855 46420819
Secondary immunodeficiency 13.80 10.28 22 263366 965 46421709
Arachnoiditis 13.80 10.28 13 263375 327 46422347
Diabetes mellitus 13.77 10.28 199 263189 49866 46372808
Punctate keratitis 13.75 10.28 17 263371 586 46422088
Capillary leak syndrome 13.75 10.28 32 263356 1865 46420809
Learning disability 13.71 10.28 8 263380 93 46422581
Lentigo maligna 13.69 10.28 10 263378 174 46422500
Osteomyelitis bacterial 13.69 10.28 10 263378 174 46422500
Morganella infection 13.65 10.28 15 263373 455 46422219
Akathisia 13.64 10.28 14 263374 7700 46414974
Adenoviral haemorrhagic cystitis 13.63 10.28 9 263379 132 46422542
Intraductal proliferative breast lesion 13.60 10.28 39 263349 2583 46420091
Muscle rigidity 13.57 10.28 22 263366 9939 46412735
Urinary tract infection enterococcal 13.56 10.28 37 263351 2381 46420293
Pseudomyopia 13.52 10.28 7 263381 63 46422611
Recalled product administered 13.48 10.28 11 263377 227 46422447
Electrocardiogram QRS complex prolonged 13.39 10.28 7 263381 5442 46417232
Forced expiratory volume decreased 13.39 10.28 6 263382 5098 46417576
Therapeutic response delayed 13.37 10.28 16 263372 533 46422141
Respiratory depth decreased 13.36 10.28 6 263382 38 46422636
Acute myeloid leukaemia 13.34 10.28 142 263246 15636 46407038
Epstein Barr virus positive mucocutaneous ulcer 13.32 10.28 11 263377 231 46422443
Rectal adenocarcinoma 13.31 10.28 17 263371 606 46422068
Listeria encephalitis 13.31 10.28 10 263378 182 46422492
Genital rash 13.28 10.28 15 263373 469 46422205
Sialoadenitis 13.27 10.28 25 263363 1255 46421419
Ankle fracture 13.26 10.28 44 263344 15467 46407207
Hyperpyrexia 13.26 10.28 40 263348 2726 46419948
Disease recurrence 13.25 10.28 161 263227 18310 46404364
Atypical pneumonia 13.21 10.28 46 263342 3381 46419293
Head injury 13.20 10.28 83 263305 24553 46398121
Arteriosclerosis coronary artery 13.11 10.28 16 263372 8140 46414534
Staphylococcal sepsis 13.11 10.28 80 263308 7452 46415222
Aqueous humour leakage 13.10 10.28 4 263384 6 46422668
Haemophilus bacteraemia 13.10 10.28 4 263384 6 46422668
Amoebic brain abscess 13.10 10.28 4 263384 6 46422668
Apathy 13.07 10.28 13 263375 7255 46415419
Panniculitis 13.05 10.28 8 263380 5696 46416978
Injection site irritation 12.99 10.28 4 263384 4283 46418391
Autonomic neuropathy 12.96 10.28 18 263370 697 46421977
Uterine leiomyoma 12.90 10.28 16 263372 8083 46414591
Tendon disorder 12.90 10.28 6 263382 4989 46417685
Hyperproteinaemia 12.89 10.28 7 263381 70 46422604
Leukaemia recurrent 12.87 10.28 25 263363 1284 46421390
Histiocytic sarcoma 12.81 10.28 7 263381 71 46422603
Arteriosclerosis 12.79 10.28 22 263366 9711 46412963
Rotator cuff syndrome 12.79 10.28 29 263359 11554 46411120
Productive cough 12.79 10.28 205 263183 50510 46372164
Conjunctival hyperaemia 12.76 10.28 32 263356 1957 46420717
Feeling abnormal 12.73 10.28 576 262812 124484 46298190
Lipogranuloma 12.73 10.28 4 263384 7 46422667
Catheter site bruise 12.70 10.28 12 263376 303 46422371
Malignant transformation 12.70 10.28 12 263376 303 46422371
Oedema peripheral 12.67 10.28 1056 262332 158650 46264024
Alveolitis 12.67 10.28 37 263351 2476 46420198
Hernia 12.66 10.28 22 263366 9673 46413001
Lactose intolerance 12.66 10.28 36 263352 2373 46420301
Enterocolitis infectious 12.63 10.28 27 263361 1486 46421188
Premature baby 12.62 10.28 157 263231 17955 46404719
Liver injury 12.60 10.28 47 263341 15954 46406720
Sinus polyp 12.60 10.28 12 263376 306 46422368
Skin sensitisation 12.59 10.28 19 263369 794 46421880
Ovarian cancer 12.59 10.28 65 263323 5690 46416984
Bradyphrenia 12.58 10.28 10 263378 6220 46416454
Cleft palate repair 12.55 10.28 3 263385 0 46422674
Oropharyngeal squamous cell carcinoma 12.55 10.28 3 263385 0 46422674
Bone debridement 12.55 10.28 13 263375 368 46422306
Stress fracture 12.53 10.28 13 263375 7114 46415560
Enterococcal sepsis 12.46 10.28 25 263363 1315 46421359
Disability 12.45 10.28 24 263364 10143 46412531
Clostridium difficile infection 12.45 10.28 205 263183 24898 46397776
White blood cell count increased 12.43 10.28 175 263213 44044 46378630
Urosepsis 12.43 10.28 137 263251 15216 46407458
Vascular compression 12.43 10.28 8 263380 112 46422562
Mantle cell lymphoma 12.43 10.28 16 263372 575 46422099
Metastatic malignant melanoma 12.41 10.28 25 263363 1319 46421355
Dysphonia 12.39 10.28 294 263094 38120 46384554
Blood thyroid stimulating hormone increased 12.39 10.28 9 263379 5860 46416814
Precursor B-lymphoblastic lymphoma 12.38 10.28 4 263384 8 46422666
Delusion 12.36 10.28 28 263360 11160 46411514
Choroiditis 12.35 10.28 9 263379 156 46422518
Thiopurine methyltransferase decreased 12.35 10.28 12 263376 314 46422360
Endocarditis bacterial 12.34 10.28 16 263372 579 46422095
Eye infection 12.33 10.28 91 263297 9032 46413642
Emphysema 12.33 10.28 20 263368 9034 46413640
Drug-induced liver injury 12.33 10.28 88 263300 25280 46397394
Blood magnesium decreased 12.31 10.28 105 263283 10887 46411787
Hypothalamic pituitary adrenal axis suppression 12.30 10.28 9 263379 157 46422517
Varicella zoster virus infection 12.30 10.28 35 263353 2308 46420366
Infusion site phlebitis 12.29 10.28 6 263382 47 46422627
Intracranial hypotension 12.25 10.28 12 263376 317 46422357
Type 2 diabetes mellitus 12.24 10.28 64 263324 19811 46402863
Sternal fracture 12.23 10.28 27 263361 1519 46421155
Paraparesis 12.23 10.28 31 263357 1908 46420766
Actinomycosis 12.22 10.28 22 263366 1066 46421608
Peritonitis viral 12.19 10.28 6 263382 48 46422626
Renal disorder 12.17 10.28 215 263173 26471 46396203
Skin striae 12.15 10.28 22 263366 1071 46421603
Herpes simplex 12.12 10.28 76 263312 7147 46415527
Oral pain 12.11 10.28 202 263186 24595 46398079
Fungal abscess central nervous system 12.07 10.28 4 263384 9 46422665
Epistaxis 12.01 10.28 460 262928 63845 46358829
JC virus infection 12.01 10.28 28 263360 1634 46421040
Thrombophlebitis superficial 12 10.28 58 263330 4945 46417729
Major depression 11.99 10.28 12 263376 6678 46415996
Impaired healing 11.96 10.28 141 263247 36602 46386072
Brain neoplasm 11.96 10.28 48 263340 3776 46418898
Aplasia pure red cell 11.93 10.28 5 263383 4420 46418254
Deformity 11.92 10.28 14 263374 7243 46415431
Thyroid neoplasm 11.91 10.28 3 263385 3666 46419008
Immune effector cell-associated neurotoxicity syndrome 11.88 10.28 17 263371 677 46421997
Diastolic hypotension 11.87 10.28 7 263381 83 46422591
Ventricular septal defect 11.81 10.28 4 263384 4030 46418644
Sputum discoloured 11.80 10.28 35 263353 12743 46409931
Light chain analysis 11.78 10.28 4 263384 10 46422664
Gastric perforation 11.76 10.28 24 263364 1278 46421396
Blood calcium abnormal 11.76 10.28 19 263369 843 46421831
Pulmonary tuberculosis 11.74 10.28 6 263382 4725 46417949
Metapneumovirus infection 11.72 10.28 18 263370 764 46421910
Injection site discolouration 11.71 10.28 13 263375 6897 46415777
Brain neoplasm malignant 11.67 10.28 19 263369 848 46421826
Leukaemic lymphoma 11.66 10.28 7 263381 86 46422588
Pulmonary fibrosis 11.66 10.28 66 263322 20026 46402648
Low density lipoprotein increased 11.66 10.28 10 263378 5990 46416684
Meniscus injury 11.64 10.28 10 263378 5986 46416688
Blastic plasmacytoid dendritic cell neoplasia 11.64 10.28 5 263383 28 46422646
Laryngeal inflammation 11.63 10.28 8 263380 126 46422548
Myeloma cast nephropathy 11.63 10.28 8 263380 126 46422548
Acute respiratory distress syndrome 11.61 10.28 181 263207 21741 46400933
Tonsillar disorder 11.61 10.28 20 263368 936 46421738
Nasopharyngitis 11.59 10.28 731 262657 153267 46269407
Blood pressure diastolic increased 11.55 10.28 10 263378 5964 46416710
Gastritis 11.55 10.28 131 263257 34247 46388427
Iris atrophy 11.50 10.28 6 263382 55 46422619
Superior vena cava occlusion 11.50 10.28 6 263382 55 46422619
Visual acuity reduced 11.50 10.28 182 263206 21931 46400743
Pulmonary artery thrombosis 11.47 10.28 17 263371 699 46421975
Mitral valve incompetence 11.45 10.28 61 263327 18791 46403883
Protein total abnormal 11.43 10.28 12 263376 345 46422329
Frequent bowel movements 11.38 10.28 35 263353 12597 46410077
Musculoskeletal chest pain 11.38 10.28 154 263234 17952 46404722
Human rhinovirus test positive 11.37 10.28 8 263380 131 46422543
Sciatica 11.30 10.28 62 263326 18958 46403716
Anger 11.29 10.28 32 263356 11820 46410854
Cyst 11.28 10.28 33 263355 12067 46410607
Simple partial seizures 11.28 10.28 15 263373 557 46422117
Pharyngitis streptococcal 11.26 10.28 19 263369 8449 46414225
Throat tightness 11.16 10.28 171 263217 20468 46402206
Staphylococcal bacteraemia 11.16 10.28 56 263332 4848 46417826
Flat anterior chamber of eye 11.14 10.28 6 263382 59 46422615
Oxygen saturation 11.10 10.28 9 263379 184 46422490
Blood corticotrophin increased 11.09 10.28 5 263383 32 46422642
Gene mutation 11.08 10.28 21 263367 1059 46421615
Encephalitis 11.06 10.28 76 263312 7372 46415302
Large intestine polyp 11.05 10.28 17 263371 7844 46414830
Substance-induced mood disorder 11.02 10.28 4 263384 13 46422661
Ear infection staphylococcal 11.02 10.28 4 263384 13 46422661
Eye discharge 11.02 10.28 56 263332 4872 46417802
Wrist fracture 11.00 10.28 31 263357 11472 46411202
Blood alkaline phosphatase abnormal 11.00 10.28 12 263376 361 46422313
Appendiceal abscess 10.98 10.28 9 263379 187 46422487
Pneumonia parainfluenzae viral 10.97 10.28 6 263382 61 46422613
Gastrointestinal toxicity 10.96 10.28 51 263337 4280 46418394
Ocular hyperaemia 10.93 10.28 164 263224 19546 46403128
Meningitis streptococcal 10.91 10.28 8 263380 140 46422534
Tremor 10.89 10.28 775 262613 114864 46307810
Bundle branch block left 10.89 10.28 12 263376 6387 46416287
Device related infection 10.87 10.28 173 263215 20868 46401806
Hyperammonaemia 10.83 10.28 54 263334 4662 46418012
Necrotising fasciitis 10.80 10.28 36 263352 2587 46420087
Ovarian cancer recurrent 10.80 10.28 20 263368 991 46421683
Retinal detachment 10.74 10.28 57 263331 5043 46417631
Phyllodes tumour 10.72 10.28 5 263383 35 46422639
Fungaemia 10.71 10.28 30 263358 1961 46420713
Colony stimulating factor therapy 10.68 10.28 11 263377 309 46422365
Candida pneumonia 10.68 10.28 8 263380 145 46422529
Macular hole 10.67 10.28 17 263371 745 46421929
Eye swelling 10.66 10.28 166 263222 19937 46402737
Tubulointerstitial nephritis 10.65 10.28 45 263343 14743 46407931
Visceral leishmaniasis 10.63 10.28 13 263375 443 46422231
Arterial occlusive disease 10.63 10.28 7 263381 4797 46417877
Aplastic anaemia 10.63 10.28 73 263315 7080 46415594
Limb injury 10.59 10.28 64 263324 19110 46403564
Papillary serous endometrial carcinoma 10.59 10.28 4 263384 15 46422659
Blood stem cell transplant failure 10.58 10.28 8 263380 147 46422527
Human herpesvirus 6 infection 10.52 10.28 34 263354 2405 46420269
Chest pain 10.50 10.28 854 262534 175470 46247204
Fungal disease carrier 10.49 10.28 3 263385 3 46422671
Flavobacterium infection 10.49 10.28 3 263385 3 46422671
Cataract operation 10.49 10.28 5 263383 4098 46418576
Injection site nodule 10.48 10.28 3 263385 3368 46419306
Anterior chamber flare 10.47 10.28 7 263381 105 46422569
Papule 10.45 10.28 50 263338 4245 46418429
Postoperative wound infection 10.43 10.28 21 263367 8732 46413942
Intracranial tumour haemorrhage 10.40 10.28 8 263380 151 46422523
Demyelination 10.40 10.28 10 263378 5670 46417004
Skin ulcer 10.40 10.28 125 263263 32333 46390341
Palmar erythema 10.35 10.28 24 263364 1396 46421278
Nodule 10.33 10.28 49 263339 15556 46407118
Salmonella bacteraemia 10.30 10.28 7 263381 108 46422566

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 5015.96 11.15 3933 251920 49529 29647096
Neuropathy peripheral 1149.12 11.15 2115 253738 68360 29628265
Neutropenia 794.70 11.15 2658 253195 125882 29570743
Pneumonia 737.54 11.15 5124 250729 329182 29367443
Completed suicide 717.53 11.15 31 255822 99461 29597164
Thrombocytopenia 643.76 11.15 2593 253260 134451 29562174
Drug abuse 587.01 11.15 27 255826 82045 29614580
Febrile neutropenia 538.85 11.15 2066 253787 104627 29591998
Drug interaction 507.31 11.15 575 255278 198993 29497632
Deep vein thrombosis 462.52 11.15 1348 254505 59153 29637472
Plasma cell myeloma recurrent 440.28 11.15 305 255548 3109 29693516
Platelet count decreased 433.94 11.15 1926 253927 104203 29592422
Unevaluable event 420.01 11.15 874 254979 30911 29665714
Pancytopenia 356.18 11.15 1555 254298 83497 29613128
Overdose 353.36 11.15 139 255714 84198 29612427
Disease progression 341.84 11.15 1470 254383 78404 29618221
Intentional overdose 332.63 11.15 4 255849 41477 29655148
White blood cell count decreased 308.47 11.15 1477 254376 82470 29614155
Plasmacytoma 305.13 11.15 243 255610 3113 29693512
Pulmonary embolism 297.46 11.15 1389 254464 76746 29619879
Thrombosis 292.42 11.15 909 254944 41322 29655303
Full blood count decreased 291.95 11.15 500 255353 15217 29681408
Rheumatoid arthritis 280.61 11.15 18 255835 41179 29655446
Psoriasis 226.42 11.15 44 255809 42462 29654163
Suicide attempt 225.41 11.15 25 255828 36672 29659953
Rhabdomyolysis 223.30 11.15 133 255720 63447 29633178
Constipation 220.65 11.15 1685 254168 111221 29585404
Drug ineffective 216.10 11.15 1866 253987 338521 29358104
Neutrophil count decreased 207.20 11.15 814 255039 41640 29654985
Fatigue 207.07 11.15 3864 251989 316809 29379816
Plasma cell leukaemia 206.26 11.15 117 255736 808 29695817
Sepsis 203.75 11.15 2027 253826 144368 29552257
Cytopenia 199.21 11.15 296 255557 7960 29688665
Laboratory test abnormal 196.59 11.15 450 255403 16992 29679633
Tumour lysis syndrome 183.97 11.15 366 255487 12519 29684106
Neutropenic sepsis 179.92 11.15 338 255515 11071 29685554
Suicidal ideation 178.93 11.15 44 255809 36070 29660555
Blood creatine phosphokinase increased 175.91 11.15 77 255776 43771 29652854
Hiccups 171.09 11.15 297 255556 9137 29687488
Arthralgia 169.70 11.15 593 255260 135198 29561427
Intentional product misuse 155.54 11.15 51 255802 34616 29662009
Myocardial infarction 143.60 11.15 569 255284 125056 29571569
Septic shock 143.52 11.15 983 254870 62624 29634001
Adverse drug reaction 140.09 11.15 476 255377 22669 29673956
Pyrexia 139.95 11.15 3395 252458 291094 29405531
Coronary artery disease 139.75 11.15 131 255722 49581 29647044
Injection site pain 137.02 11.15 44 255809 30266 29666359
Malignant neoplasm progression 135.04 11.15 1068 254785 71219 29625406
Strongyloidiasis 133.14 11.15 130 255723 2216 29694409
Endophthalmitis 130.72 11.15 155 255698 3325 29693300
Depression 128.99 11.15 372 255481 90065 29606560
Squamous cell carcinoma of skin 128.22 11.15 257 255596 8838 29687787
Osteonecrosis 127.43 11.15 364 255489 15771 29680854
Headache 126.85 11.15 974 254879 181332 29515293
Venoocclusive liver disease 126.24 11.15 213 255640 6400 29690225
Inappropriate schedule of product administration 126.09 11.15 93 255760 39635 29656990
Hospitalisation 124.32 11.15 117 255736 44202 29652423
Hypoglycaemia 121.55 11.15 154 255699 50827 29645798
Mucosal inflammation 120.96 11.15 549 255304 29945 29666680
Leukopenia 118.53 11.15 854 254999 55305 29641320
Wrong technique in product usage process 118.33 11.15 59 255794 31096 29665529
Pneumocystis jirovecii pneumonia 117.02 11.15 367 255486 16753 29679872
Myalgia 114.78 11.15 308 255545 76359 29620266
Intraocular pressure increased 114.22 11.15 177 255676 4943 29691682
Condition aggravated 112.92 11.15 702 255151 137164 29559461
Drug dependence 111.39 11.15 23 255830 21272 29675353
Drug withdrawal syndrome 110.92 11.15 18 255835 19791 29676834
Light chain analysis increased 110.56 11.15 82 255771 938 29695687
Osteonecrosis of jaw 110.13 11.15 380 255473 18238 29678387
Complication of device insertion 108.66 11.15 39 255814 67 29696558
Myelodysplastic syndrome 103.96 11.15 375 255478 18403 29678222
Neuroleptic malignant syndrome 102.89 11.15 10 255843 16285 29680340
Aggression 102.85 11.15 98 255755 36809 29659816
Febrile bone marrow aplasia 101.47 11.15 218 255635 7879 29688746
Drug hypersensitivity 101.25 11.15 277 255576 68242 29628383
Death 100.87 11.15 3864 251989 353419 29343206
Serotonin syndrome 100.75 11.15 16 255837 17875 29678750
Hallucination 100.40 11.15 165 255688 48894 29647731
Off label use 97.69 11.15 2803 253050 246487 29450138
Psoriatic arthropathy 96.11 11.15 11 255842 15750 29680875
Anxiety 95.82 11.15 418 255435 89453 29607172
Angioedema 93.84 11.15 93 255760 34291 29662334
Bone marrow failure 93.70 11.15 502 255351 29283 29667342
International normalised ratio increased 90.92 11.15 168 255685 47571 29649054
Cytomegalovirus chorioretinitis 90.33 11.15 125 255728 3143 29693482
Diarrhoea 89.22 11.15 3592 252261 330511 29366114
Lactic acidosis 89.19 11.15 81 255772 31132 29665493
Asthma 86.50 11.15 109 255744 36065 29660560
Haematotoxicity 85.36 11.15 173 255680 5997 29690628
Electrocardiogram QT prolonged 84.63 11.15 109 255744 35726 29660899
Acute lymphocytic leukaemia recurrent 84.43 11.15 109 255744 2558 29694067
Polyneuropathy 84.09 11.15 257 255596 11566 29685059
Diffuse large B-cell lymphoma recurrent 83.28 11.15 96 255757 1996 29694629
Monoclonal immunoglobulin present 83.08 11.15 66 255787 842 29695783
Hypofibrinogenaemia 82.06 11.15 85 255768 1560 29695065
Hyperkalaemia 81.18 11.15 290 255563 65720 29630905
Body height decreased 80.39 11.15 127 255726 3607 29693018
Tooth disorder 79.58 11.15 214 255639 8947 29687678
Intentional self-injury 78.74 11.15 11 255842 13521 29683104
Posterior reversible encephalopathy syndrome 78.27 11.15 206 255647 8501 29688124
Hypercalcaemia 78.27 11.15 260 255593 12235 29684390
Poisoning 77.40 11.15 5 255848 11377 29685248
Bone lesion 77.02 11.15 104 255749 2553 29694072
Hyperglycaemia 76.98 11.15 540 255313 34660 29661965
Anaemia 76.83 11.15 2322 253531 205670 29490955
Stomatitis 75.81 11.15 562 255291 36717 29659908
Corneal oedema 73.14 11.15 72 255781 1240 29695385
Peripheral sensory neuropathy 72.94 11.15 158 255695 5743 29690882
Infusion related reaction 72.79 11.15 594 255259 39970 29656655
Contraindicated product administered 72.75 11.15 28 255825 17203 29679422
Product quality issue 72.12 11.15 35 255818 18739 29677886
Peritonitis bacterial 71.79 11.15 7 255846 11371 29685254
Acute lymphocytic leukaemia 71.05 11.15 108 255745 2964 29693661
Incorrect dose administered 70.16 11.15 101 255752 31585 29665040
Infection 69.81 11.15 994 254859 77080 29619545
Product substitution issue 69.47 11.15 4 255849 10031 29686594
Product prescribing error 69.31 11.15 28 255825 16705 29679920
Haemophagocytic lymphohistiocytosis 68.86 11.15 212 255641 9579 29687046
Amyloidosis 68.62 11.15 88 255765 2051 29694574
Bone disorder 67.36 11.15 166 255687 6575 29690050
Cataract 67.31 11.15 366 255487 21469 29675156
Respiratory arrest 67.03 11.15 91 255762 29167 29667458
Dehydration 66.34 11.15 1450 254403 122089 29574536
Therapy partial responder 65.36 11.15 115 255738 3576 29693049
Sedation 65.26 11.15 29 255824 16344 29680281
Multiple sclerosis relapse 65.19 11.15 8 255845 10854 29685771
Stress 64.67 11.15 47 255806 20188 29676437
Abnormal behaviour 64.67 11.15 74 255779 25549 29671076
Treatment noncompliance 62.58 11.15 74 255779 25179 29671446
Hallucination, visual 61.96 11.15 30 255823 16083 29680542
Neoplasm progression 60.28 11.15 309 255544 17714 29678911
Coma 59.37 11.15 164 255689 40285 29656340
Sopor 59.31 11.15 11 255842 10980 29685645
Accidental overdose 58.99 11.15 42 255811 18233 29678392
Acute kidney injury 58.97 11.15 1836 254017 272006 29424619
Hepatic cirrhosis 58.23 11.15 32 255821 15967 29680658
Blood pressure increased 57.90 11.15 368 255485 71560 29625065
Infective pulmonary exacerbation of cystic fibrosis 57.60 11.15 4 255849 8568 29688057
Dyskinesia 57.36 11.15 61 255792 21773 29674852
Surgery 57.34 11.15 14 255839 11537 29685088
Somnolence 57.26 11.15 539 255314 96224 29600401
Colitis ulcerative 56.85 11.15 26 255827 14408 29682217
Blood pressure fluctuation 56.79 11.15 40 255813 17463 29679162
Labelled drug-drug interaction medication error 55.91 11.15 11 255842 10527 29686098
Melaena 55.88 11.15 121 255732 32316 29664309
Gastrointestinal haemorrhage 55.49 11.15 451 255402 82995 29613630
Bone pain 54.71 11.15 313 255540 18713 29677912
Synovitis 54.52 11.15 9 255844 9774 29686851
Ageusia 54.04 11.15 184 255669 8769 29687856
Musculoskeletal stiffness 53.77 11.15 144 255709 35737 29660888
Diffuse large B-cell lymphoma refractory 53.61 11.15 48 255805 729 29695896
Respiratory tract infection 53.37 11.15 268 255585 15238 29681387
Spinal cord compression 53.36 11.15 105 255748 3561 29693064
Influenza 53.13 11.15 586 255267 42812 29653813
Glioblastoma multiforme 53.09 11.15 50 255803 813 29695812
Lymphopenia 52.94 11.15 238 255615 12925 29683700
Erectile dysfunction 52.88 11.15 46 255807 18056 29678569
Foetal exposure during pregnancy 51.54 11.15 153 255700 36718 29659907
Metabolic acidosis 50.54 11.15 158 255695 37303 29659322
Osteolysis 49.76 11.15 64 255789 1496 29695129
Eosinophilia 49.68 11.15 70 255783 22090 29674535
Full blood count increased 49.33 11.15 47 255806 776 29695849
Neurotoxicity 49.07 11.15 233 255620 12949 29683676
Metastases to central nervous system 48.71 11.15 155 255698 7129 29689496
Cushingoid 48.66 11.15 81 255772 2406 29694219
Peripheral motor neuropathy 48.18 11.15 65 255788 1594 29695031
Agitation 48.08 11.15 268 255585 53805 29642820
Microsporidia infection 47.09 11.15 40 255813 564 29696061
Asthenia 46.92 11.15 2325 253528 218965 29477660
COVID-19 46.82 11.15 287 255566 17591 29679034
Bacteraemia 46.73 11.15 259 255594 15301 29681324
H1N1 influenza 46.63 11.15 49 255804 915 29695710
Acute myeloid leukaemia 46.49 11.15 288 255565 17718 29678907
Rash 46.44 11.15 2043 253810 189846 29506779
Injury 46.42 11.15 71 255782 21660 29674965
Glycosylated haemoglobin increased 46.16 11.15 12 255841 9479 29687146
Pathological fracture 45.98 11.15 106 255747 4020 29692605
Bradycardia 45.48 11.15 350 255503 65176 29631449
Ventricular tachycardia 45.39 11.15 84 255769 23778 29672847
Chest pain 45.31 11.15 719 255134 116908 29579717
Prescribed overdose 45.28 11.15 9 255844 8552 29688073
Corneal decompensation 45.26 11.15 12 255841 0 29696625
Respiratory depression 44.87 11.15 21 255832 11482 29685143
Parainfluenzae virus infection 44.82 11.15 70 255783 1968 29694657
Muscle rigidity 44.45 11.15 16 255837 10245 29686380
Hepatitis C 44.42 11.15 29 255824 13176 29683449
Sleep apnoea syndrome 44.39 11.15 47 255806 16810 29679815
Large intestine perforation 44.23 11.15 155 255698 7496 29689129
Nightmare 44.17 11.15 24 255829 12052 29684573
Torsade de pointes 43.88 11.15 5 255848 7185 29689440
Mucormycosis 43.70 11.15 121 255732 5147 29691478
Cardio-respiratory arrest 43.68 11.15 298 255555 57008 29639617
Loss of personal independence in daily activities 43.51 11.15 73 255780 21462 29675163
Extrapyramidal disorder 42.52 11.15 19 255834 10674 29685951
Cardiac failure congestive 42.24 11.15 489 255364 83918 29612707
Spinal compression fracture 42.00 11.15 133 255720 6101 29690524
Injection site erythema 41.83 11.15 34 255819 13800 29682825
Device issue 41.80 11.15 8 255845 7808 29688817
Pemphigoid 41.79 11.15 7 255846 7521 29689104
Adenocarcinoma of colon 41.67 11.15 89 255764 3203 29693422
Myelopathy 41.61 11.15 66 255787 1881 29694744
Palpitations 41.58 11.15 147 255706 33426 29663199
Hyperviscosity syndrome 40.96 11.15 25 255828 201 29696424
Dizziness 40.85 11.15 1311 254542 193598 29503027
Malignant neoplasm of unknown primary site 40.32 11.15 30 255823 345 29696280
Substance abuse 40.31 11.15 6 255847 7034 29689591
Pain 39.92 11.15 1146 254707 171495 29525130
Atrial fibrillation 39.24 11.15 1205 254648 106919 29589706
Diverticular perforation 39.19 11.15 85 255768 3092 29693533
Akathisia 38.97 11.15 3 255850 5901 29690724
Arteriosclerosis 38.94 11.15 22 255831 10811 29685814
Pneumonia influenzal 38.92 11.15 52 255801 1263 29695362
Transplant rejection 38.79 11.15 15 255838 9191 29687434
Cardiac amyloidosis 38.70 11.15 40 255813 732 29695893
Haematuria 38.35 11.15 225 255628 44609 29652016
Herpes zoster 38.35 11.15 408 255445 29535 29667090
Product use in unapproved indication 38.25 11.15 861 254992 72832 29623793
Gynaecomastia 37.95 11.15 12 255841 8339 29688286
Myelosuppression 37.81 11.15 143 255710 7179 29689446
Injection site swelling 37.51 11.15 14 255839 8766 29687859
Fear 37.48 11.15 23 255830 10802 29685823
Kidney transplant rejection 37.47 11.15 9 255844 7500 29689125
Autonomic neuropathy 37.47 11.15 42 255811 846 29695779
Road traffic accident 37.21 11.15 55 255798 17016 29679609
Pancreatitis 36.88 11.15 173 255680 36317 29660308
Hyperlipidaemia 36.37 11.15 39 255814 13868 29682757
Drug level increased 36.36 11.15 63 255790 18291 29678334
Pulmonary arterial hypertension 36.24 11.15 17 255836 9284 29687341
Emotional distress 36.14 11.15 49 255804 15716 29680909
Cytokine release syndrome 35.83 11.15 174 255679 9759 29686866
Decreased appetite 35.77 11.15 1594 254259 148316 29548309
Product administration error 35.76 11.15 42 255811 14335 29682290
Parkinsonism 35.72 11.15 9 255844 7260 29689365
Cellulitis orbital 35.69 11.15 27 255826 319 29696306
Coronary artery occlusion 35.54 11.15 26 255827 11131 29685494
Pulmonary thrombosis 35.38 11.15 127 255726 6216 29690409
Disturbance in attention 35.32 11.15 86 255767 22043 29674582
Back pain 35.27 11.15 1136 254717 101460 29595165
Cardiac arrest 35.26 11.15 569 255284 92281 29604344
Panic attack 35.19 11.15 15 255838 8666 29687959
Disseminated aspergillosis 34.86 11.15 17 255836 82 29696543
Diffuse large B-cell lymphoma 34.76 11.15 146 255707 7695 29688930
Sexual dysfunction 34.63 11.15 5 255848 5996 29690629
Arteriosclerosis coronary artery 34.38 11.15 27 255826 11149 29685476
Wheezing 34.10 11.15 142 255711 30796 29665829
Underdose 34.09 11.15 32 255821 12109 29684516
Type 2 diabetes mellitus 33.66 11.15 40 255813 13582 29683043
Hallucination, auditory 33.61 11.15 21 255832 9768 29686857
Withdrawal syndrome 33.58 11.15 28 255825 11222 29685403
Seasonal allergy 33.50 11.15 103 255750 4650 29691975
Escherichia sepsis 33.39 11.15 92 255761 3902 29692723
Pain in extremity 33.25 11.15 703 255150 109518 29587107
Hepatitis cholestatic 32.88 11.15 13 255840 7859 29688766
Substance-induced psychotic disorder 32.82 11.15 49 255804 1323 29695302
Compression fracture 32.78 11.15 76 255777 2893 29693732
Injection site haemorrhage 32.77 11.15 13 255840 7842 29688783
Blood pressure systolic increased 32.62 11.15 49 255804 15061 29681564
Spinal fracture 32.57 11.15 129 255724 6619 29690006
Ischaemic cardiomyopathy 32.52 11.15 7 255846 6290 29690335
Ulcerative keratitis 32.36 11.15 49 255804 1340 29695285
Medication error 32.31 11.15 83 255770 20889 29675736
Chronic kidney disease 32.30 11.15 190 255663 37648 29658977
Minimal residual disease 32.26 11.15 22 255831 218 29696407
Rectal haemorrhage 32.24 11.15 171 255682 34768 29661857
Tardive dyskinesia 32.20 11.15 3 255850 5054 29691571
Alcohol abuse 31.98 11.15 4 255849 5349 29691276
Loss of consciousness 31.96 11.15 481 255372 78894 29617731
Ocular hypertension 31.85 11.15 36 255817 732 29695893
Exposure during pregnancy 31.61 11.15 20 255833 9241 29687384
Differentiation syndrome 31.51 11.15 44 255809 1116 29695509
Haematoma 30.93 11.15 103 255750 23850 29672775
Taste disorder 30.89 11.15 82 255771 3401 29693224
Injection site bruising 30.85 11.15 12 255841 7326 29689299
Respiratory failure 30.70 11.15 1099 254754 99543 29597082
Dystonia 30.55 11.15 23 255830 9704 29686921
Coronary artery bypass 30.50 11.15 4 255849 5158 29691467
Refractory anaemia with an excess of blasts 30.41 11.15 26 255827 370 29696255
Cholestasis 30.39 11.15 110 255743 24840 29671785
Angina pectoris 30.39 11.15 139 255714 29379 29667246
Lower respiratory tract infection 30.11 11.15 355 255498 26359 29670266
Hypocalcaemia 30.10 11.15 297 255556 21079 29675546
Refractory cytopenia with multilineage dysplasia 29.98 11.15 18 255835 140 29696485
Haematochezia 29.66 11.15 171 255682 34051 29662574
Knee arthroplasty 29.61 11.15 6 255847 5624 29691001
Visual acuity reduced 29.47 11.15 234 255619 15612 29681013
Heart block congenital 29.42 11.15 12 255841 34 29696591
Therapeutic product effect incomplete 29.36 11.15 169 255684 33665 29662960
Delusion 28.78 11.15 36 255817 11953 29684672
Basal cell carcinoma 28.65 11.15 235 255618 15833 29680792
Nephrolithiasis 28.52 11.15 112 255741 24698 29671927
Pneumonitis 28.41 11.15 359 255494 27095 29669530
Cerebrovascular accident 28.32 11.15 522 255331 82955 29613670
Arthritis 28.15 11.15 110 255743 24291 29672334
B-cell lymphoma recurrent 28.14 11.15 31 255822 612 29696013
Blood immunoglobulin M increased 28.14 11.15 19 255834 185 29696440
Blood loss anaemia 28.13 11.15 15 255838 7612 29689013
Depressed level of consciousness 28.02 11.15 201 255652 38021 29658604
COVID-19 pneumonia 28.01 11.15 94 255759 4446 29692179
Accidental exposure to product 28.00 11.15 27 255826 10088 29686537
Liver function test abnormal 27.72 11.15 153 255700 30797 29665828
Mobility decreased 27.62 11.15 121 255732 25878 29670747
Cardiac murmur 27.40 11.15 12 255841 6822 29689803
Hepatocellular carcinoma 27.37 11.15 25 255828 9585 29687040
Hypertension 27.15 11.15 809 255044 120545 29576080
Meningitis pneumococcal 27.13 11.15 16 255837 120 29696505
Anger 27.11 11.15 33 255820 11087 29685538
Malaise 27.11 11.15 1158 254695 165804 29530821
Paraplegia 27.09 11.15 66 255787 2595 29694030
Device malfunction 27.03 11.15 18 255835 8093 29688532
Drug abuser 27.01 11.15 3 255850 4398 29692227
Blood triglycerides increased 26.96 11.15 49 255804 13968 29682657
Embolism 26.90 11.15 125 255728 6884 29689741
Ecthyma 26.80 11.15 23 255830 329 29696296
Therapeutic response unexpected 26.77 11.15 22 255831 8881 29687744
Middle insomnia 26.77 11.15 8 255845 5765 29690860
Blood calcium increased 26.70 11.15 72 255781 3015 29693610
Haematemesis 26.61 11.15 124 255729 26079 29670546
Flushing 26.53 11.15 376 255477 29116 29667509
Angina unstable 26.50 11.15 40 255813 12270 29684355
Therapeutic product effect decreased 26.44 11.15 143 255710 28933 29667692
Frequent bowel movements 26.24 11.15 20 255833 8385 29688240
Jaw disorder 26.10 11.15 59 255794 2208 29694417
Myoclonus 26.09 11.15 46 255807 13266 29683359
Product storage error 25.97 11.15 11 255842 6380 29690245
Drug reaction with eosinophilia and systemic symptoms 25.97 11.15 140 255713 28348 29668277
Red blood cell sedimentation rate increased 25.96 11.15 15 255838 7280 29689345
Joint stiffness 25.90 11.15 25 255828 9336 29687289
Hepatitis B reactivation 25.79 11.15 68 255785 2809 29693816
Muscle spasms 25.78 11.15 731 255122 64107 29632518
Osteoarthritis 25.74 11.15 76 255777 18273 29678352
Faeces discoloured 25.73 11.15 50 255803 13896 29682729
Ankylosing spondylitis 25.65 11.15 4 255849 4530 29692095
Chronic obstructive pulmonary disease 25.55 11.15 261 255592 45865 29650760
Blood cholesterol increased 25.50 11.15 68 255785 16902 29679723
Injection site pruritus 25.48 11.15 8 255845 5584 29691041
Febrile infection 25.42 11.15 49 255804 1636 29694989
Blood immunoglobulin G increased 25.38 11.15 35 255818 877 29695748
Plasma cell myeloma refractory 25.38 11.15 11 255842 38 29696587
Bacterial sepsis 25.27 11.15 96 255757 4830 29691795
Light chain disease 25.24 11.15 14 255839 92 29696533
Abdominal pain 25.23 11.15 926 254927 134728 29561897
Schizophrenia 25.23 11.15 24 255829 9024 29687601
Fall 25.20 11.15 1283 254570 180589 29516036
Protein total increased 25.16 11.15 56 255797 2074 29694551
Intestinal perforation 25.05 11.15 141 255712 8378 29688247
Atrial septal defect 24.97 11.15 13 255840 6688 29689937
Obsessive-compulsive disorder 24.97 11.15 3 255850 4138 29692487
Salivary hypersecretion 24.93 11.15 17 255836 7549 29689076
Miosis 24.93 11.15 18 255835 7758 29688867
Multiple allergies 24.93 11.15 56 255797 2087 29694538
Tooth extraction 24.88 11.15 94 255759 4717 29691908
Mitral valve incompetence 24.80 11.15 47 255806 13187 29683438
Obesity 24.67 11.15 22 255831 8533 29688092
Eczema 24.60 11.15 48 255805 13321 29683304
Cataract subcapsular 24.46 11.15 19 255834 234 29696391
Negative pressure pulmonary oedema 24.41 11.15 18 255835 204 29696421
Neoplasm recurrence 24.24 11.15 51 255802 1816 29694809
Immunosuppression 24.23 11.15 98 255755 5077 29691548
Brain oedema 24.11 11.15 185 255668 12213 29684412
Paranoia 24.03 11.15 31 255822 10157 29686468
Blood creatinine increased 23.83 11.15 596 255257 90779 29605846
Pulmonary function test decreased 23.83 11.15 4 255849 4291 29692334
Pulmonary hypertension 23.80 11.15 83 255770 18953 29677672
Rectal adenocarcinoma 23.77 11.15 32 255821 783 29695842
Pneumonia viral 23.72 11.15 63 255790 2614 29694011
Pulmonary congestion 23.59 11.15 43 255810 12244 29684381
Anhedonia 23.57 11.15 22 255831 8347 29688278
Depressed mood 23.55 11.15 71 255782 16958 29679667
Aplasia 23.52 11.15 82 255771 3955 29692670
Choroiditis 23.17 11.15 32 255821 803 29695822
Psychotic disorder 22.94 11.15 100 255753 21415 29675210
Oral pain 22.92 11.15 149 255704 9320 29687305
Hyperhidrosis 22.92 11.15 419 255434 66671 29629954
Immunosuppressant drug level increased 22.76 11.15 6 255847 4696 29691929
Tricuspid valve incompetence 22.75 11.15 24 255829 8599 29688026
Cerebral venous thrombosis 22.74 11.15 27 255826 580 29696045
Performance status decreased 22.73 11.15 80 255773 3877 29692748
Injection site mass 22.72 11.15 7 255846 4946 29691679
Hypogammaglobulinaemia 22.67 11.15 97 255756 5155 29691470
Exposed bone in jaw 22.44 11.15 49 255804 1791 29694834
Paraproteinaemia 22.38 11.15 20 255833 303 29696322
Photosensitivity reaction 22.35 11.15 30 255823 9664 29686961
Malignant transformation 22.35 11.15 29 255824 684 29695941
Coombs positive haemolytic anaemia 22.26 11.15 30 255823 735 29695890
Dermatitis acneiform 22.23 11.15 102 255751 5587 29691038
C-reactive protein abnormal 22.14 11.15 10 255843 5583 29691042
Vertebral lesion 22.05 11.15 15 255838 148 29696477
Gastrooesophageal reflux disease 22.03 11.15 173 255680 32082 29664543
Oral candidiasis 21.98 11.15 166 255687 10905 29685720
Obstructive airways disorder 21.96 11.15 27 255826 9032 29687593
Acute myocardial infarction 21.93 11.15 319 255534 52620 29644005
Visceral leishmaniasis 21.86 11.15 24 255829 472 29696153
Diabetic ketoacidosis 21.86 11.15 67 255786 15919 29680706
Pseudomonas infection 21.85 11.15 159 255694 10323 29686302
Hypertriglyceridaemia 21.84 11.15 131 255722 7967 29688658
Irritability 21.72 11.15 112 255741 22938 29673687
Pruritus 21.72 11.15 808 255045 117396 29579229
Bone sequestrum 21.72 11.15 29 255824 704 29695921
Dyslipidaemia 21.51 11.15 11 255842 5716 29690909
Device leakage 21.50 11.15 3 255850 3691 29692934
Escherichia bacteraemia 21.50 11.15 64 255789 2838 29693787
Adenoviral hepatitis 21.32 11.15 15 255838 157 29696468
Myocardial ischaemia 21.32 11.15 76 255777 17241 29679384
Second primary malignancy 21.27 11.15 109 255744 6247 29690378
Glioblastoma 21.08 11.15 37 255816 1148 29695477
Coronary artery stenosis 20.98 11.15 28 255825 9042 29687583
Streptococcal bacteraemia 20.97 11.15 45 255808 1625 29695000
Nocardiosis 20.84 11.15 71 255782 3384 29693241
Skin striae 20.80 11.15 22 255831 414 29696211
Familial periodic paralysis 20.79 11.15 12 255841 86 29696539
Gastrointestinal perforation 20.68 11.15 73 255780 3543 29693082
Corneal perforation 20.59 11.15 14 255839 138 29696487
Product complaint 20.57 11.15 12 255841 5794 29690831
Drug level decreased 20.56 11.15 12 255841 5793 29690832
Vascular pain 20.51 11.15 14 255839 139 29696486
Ear swelling 20.51 11.15 21 255832 380 29696245
Weight fluctuation 20.46 11.15 75 255778 3709 29692916
Injection site reaction 20.35 11.15 38 255815 10722 29685903
Complications of transplanted kidney 20.30 11.15 5 255848 4096 29692529
Varices oesophageal 20.07 11.15 3 255850 3506 29693119
Steroid withdrawal syndrome 19.96 11.15 16 255837 207 29696418
Periorbital infection 19.82 11.15 13 255840 120 29696505
Capillary leak syndrome 19.79 11.15 44 255809 1628 29694997
Meningitis bacterial 19.76 11.15 35 255818 1094 29695531
Benign prostatic hyperplasia 19.67 11.15 37 255816 10410 29686215
Upper gastrointestinal haemorrhage 19.67 11.15 109 255744 21919 29674706
Cardiac failure chronic 19.55 11.15 13 255840 5850 29690775
Priapism 19.54 11.15 8 255845 4735 29691890
Viral haemorrhagic cystitis 19.53 11.15 30 255823 831 29695794
Keratitis fungal 19.50 11.15 11 255842 75 29696550
Eosinophil count increased 19.49 11.15 21 255832 7452 29689173
Blood stem cell transplant failure 19.49 11.15 21 255832 404 29696221
Bronchopulmonary aspergillosis 19.45 11.15 175 255678 12109 29684516
Autoimmune lymphoproliferative syndrome 19.40 11.15 14 255839 153 29696472
Pneumoretroperitoneum 19.32 11.15 10 255843 56 29696569
Crying 19.30 11.15 12 255841 5597 29691028
Diabetes mellitus inadequate control 19.28 11.15 51 255802 12711 29683914
Blood pressure diastolic decreased 19.23 11.15 15 255838 6216 29690409
Therapy non-responder 19.19 11.15 356 255497 29097 29667528
Gastritis 19.11 11.15 98 255755 20100 29676525
Toxic skin eruption 19.04 11.15 41 255812 10974 29685651
Swollen tongue 18.97 11.15 54 255799 13138 29683487
Macular fibrosis 18.97 11.15 20 255833 375 29696250
Progressive multifocal leukoencephalopathy 18.95 11.15 137 255716 8876 29687749
Prescribed underdose 18.94 11.15 23 255830 7736 29688889
Pneumonia escherichia 18.90 11.15 19 255834 336 29696289
JC virus infection 18.87 11.15 45 255808 1745 29694880
Tooth deposit 18.83 11.15 12 255841 105 29696520
Abnormal dreams 18.83 11.15 25 255828 8090 29688535
Acute lymphocytic leukaemia refractory 18.83 11.15 12 255841 105 29696520
Jaundice 18.75 11.15 182 255671 32304 29664321
Peripheral sensorimotor neuropathy 18.74 11.15 37 255816 1258 29695367
Intraocular pressure decreased 18.73 11.15 12 255841 106 29696519
Urticaria 18.65 11.15 341 255512 54265 29642360
Adrenal insufficiency 18.64 11.15 153 255700 10310 29686315
Body tinea 18.63 11.15 10 255843 61 29696564
Corneal lesion 18.51 11.15 7 255846 15 29696610
Right ventricular failure 18.40 11.15 25 255828 8011 29688614
Gastric ulcer 18.19 11.15 67 255786 15054 29681571
Forced expiratory volume decreased 18.09 11.15 3 255850 3247 29693378
B-cell type acute leukaemia 18.07 11.15 17 255836 276 29696349
Musculoskeletal pain 18.00 11.15 173 255680 30767 29665858
Mental disorder 17.94 11.15 57 255796 13392 29683233
Prostate cancer stage II 17.86 11.15 15 255838 208 29696417
Iron deficiency anaemia 17.85 11.15 31 255822 8993 29687632
Blood pressure measurement 17.80 11.15 13 255840 145 29696480
Alcohol use 17.78 11.15 5 255848 3750 29692875
Hypoxia 17.78 11.15 535 255318 47319 29649306
Testicular germ cell cancer metastatic 17.75 11.15 10 255843 68 29696557
Metapneumovirus infection 17.74 11.15 23 255830 542 29696083
Stem cell transplant 17.73 11.15 49 255804 2082 29694543
Chalazion 17.67 11.15 11 255842 92 29696533
Hepatitis 17.65 11.15 115 255738 22241 29674384
Blood glucose decreased 17.64 11.15 55 255798 12998 29683627
Renal injury 17.62 11.15 47 255806 11682 29684943
Necrotising retinitis 17.50 11.15 26 255827 699 29695926
Tendonitis 17.41 11.15 26 255827 8010 29688615
Pregnancy of partner 17.40 11.15 17 255836 290 29696335
Osteomyelitis 17.39 11.15 197 255656 14484 29682141
Immune reconstitution inflammatory syndrome 17.34 11.15 32 255821 9069 29687556
Disability 17.33 11.15 8 255845 4410 29692215
Hiatus hernia 17.32 11.15 21 255832 7069 29689556
Staphylococcal bacteraemia 17.31 11.15 108 255745 6660 29689965
Blood immunoglobulin A increased 17.31 11.15 17 255836 292 29696333
Neutropenic colitis 17.30 11.15 50 255803 2180 29694445
Rash pruritic 17.29 11.15 280 255573 22292 29674333
Gallbladder oedema 17.28 11.15 14 255839 184 29696441
Hypotony of eye 17.26 11.15 12 255841 123 29696502
Taeniasis 17.17 11.15 10 255843 73 29696552
Epidural lipomatosis 17.12 11.15 15 255838 221 29696404
Red blood cell count decreased 17.10 11.15 318 255535 26003 29670622
Hypothermia 17.05 11.15 35 255818 9532 29687093
Chromaturia 16.97 11.15 61 255792 13804 29682821
Non-small cell lung cancer 16.96 11.15 70 255783 3660 29692965
Joint range of motion decreased 16.89 11.15 15 255838 5830 29690795
Dysphonia 16.86 11.15 242 255611 18790 29677835
Muscle spasticity 16.64 11.15 12 255841 5176 29691449
Cerebral haematoma 16.47 11.15 9 255844 4505 29692120
Aspergillus infection 16.42 11.15 146 255707 10068 29686557
Electrocardiogram QRS complex prolonged 16.39 11.15 8 255845 4269 29692356
Tubulointerstitial nephritis 16.26 11.15 88 255765 17803 29678822
Large intestine polyp 16.26 11.15 20 255833 6689 29689936
Pulmonary fibrosis 16.25 11.15 75 255778 15815 29680810
Dysgeusia 16.24 11.15 300 255553 24501 29672124
Subdural hygroma 16.20 11.15 17 255836 317 29696308
B precursor type acute leukaemia 16.12 11.15 10 255843 83 29696542
Immunoglobulins increased 16.10 11.15 13 255840 170 29696455
Protein total abnormal 15.99 11.15 17 255836 322 29696303
Haemorrhage 15.97 11.15 287 255566 45792 29650833
Abdominal discomfort 15.95 11.15 307 255546 48484 29648141
Neck pain 15.90 11.15 109 255744 20835 29675790
Influenza like illness 15.83 11.15 141 255712 25464 29671161
VIth nerve paralysis 15.77 11.15 25 255828 712 29695913
Pneumonia parainfluenzae viral 15.72 11.15 11 255842 114 29696511
Hepatic encephalopathy 15.72 11.15 65 255788 14127 29682498
Oroantral fistula 15.68 11.15 15 255838 249 29696376
Rib fracture 15.67 11.15 172 255681 12548 29684077
Blood urea increased 15.60 11.15 182 255671 31199 29665426
Stent placement 15.59 11.15 10 255843 4586 29692039
Heart rate decreased 15.58 11.15 110 255743 20884 29675741
Pericardial haemorrhage 15.58 11.15 3 255850 2915 29693710
Peripheral swelling 15.55 11.15 654 255199 60420 29636205
Multiple organ dysfunction syndrome 15.53 11.15 677 255176 62810 29633815
Foot deformity 15.51 11.15 5 255848 3432 29693193
Abdominal pain upper 15.50 11.15 411 255442 62140 29634485
Encephalitis brain stem 15.42 11.15 9 255844 66 29696559
Diverticulum 15.36 11.15 21 255832 6712 29689913
Pneumonia fungal 15.23 11.15 90 255763 5443 29691182
Syringe issue 15.18 11.15 3 255850 2862 29693763
Cardiomegaly 15.12 11.15 68 255785 14441 29682184
VIIIth nerve lesion 15.09 11.15 4 255849 0 29696625
Drug-induced liver injury 15.05 11.15 113 255740 21161 29675464
Idiopathic pulmonary fibrosis 15.01 11.15 8 255845 4061 29692564
Spinal disorder 14.98 11.15 63 255790 3322 29693303
Corneal degeneration 14.97 11.15 6 255847 16 29696609
Antithrombin III deficiency 14.93 11.15 10 255843 96 29696529
Pneumonia aspiration 14.83 11.15 230 255623 37550 29659075
Corneal abscess 14.82 11.15 7 255846 31 29696594
Fungal sepsis 14.80 11.15 24 255829 697 29695928
Tumour perforation 14.80 11.15 15 255838 268 29696357
Intestinal atresia 14.78 11.15 9 255844 72 29696553
Phaeochromocytoma crisis 14.71 11.15 6 255847 17 29696608
Listeriosis 14.69 11.15 27 255826 869 29695756
Candida infection 14.68 11.15 198 255655 15164 29681461
Hypogeusia 14.61 11.15 26 255827 816 29695809
Hypoalbuminaemia 14.60 11.15 152 255701 10940 29685685
Blood potassium increased 14.60 11.15 80 255773 16133 29680492
Sternal fracture 14.59 11.15 21 255832 548 29696077
Nicotinic acid deficiency 14.58 11.15 9 255844 74 29696551
Glomerular filtration rate decreased 14.57 11.15 49 255804 11313 29685312
Hepatic enzyme increased 14.51 11.15 200 255653 33294 29663331
Aspiration bone marrow abnormal 14.51 11.15 10 255843 101 29696524
Respirovirus test positive 14.50 11.15 8 255845 52 29696573
Pneumonia bacterial 14.40 11.15 133 255720 9270 29687355
Hypopyon 14.39 11.15 19 255834 456 29696169
Peripheral vascular disorder 14.37 11.15 14 255839 5205 29691420
Heart rate irregular 14.31 11.15 55 255798 12204 29684421
Pneumatosis intestinalis 14.28 11.15 53 255800 2637 29693988
VIth nerve disorder 14.23 11.15 6 255847 19 29696606
Nephrogenic systemic fibrosis 14.16 11.15 10 255843 4361 29692264
Vitreous loss 14.15 11.15 5 255848 8 29696617
Renal amyloidosis 14.13 11.15 8 255845 55 29696570
Corneal thinning 14.06 11.15 11 255842 137 29696488
Sputum discoloured 14.03 11.15 22 255831 6646 29689979
Enterocolitis infectious 14.02 11.15 31 255822 1143 29695482
Transitional cell cancer of the renal pelvis and ureter 14.00 11.15 6 255847 20 29696605
Somnambulism 13.94 11.15 5 255848 3209 29693416
Eye pain 13.88 11.15 158 255695 11631 29684994
Subarachnoid haemorrhage 13.83 11.15 41 255812 9845 29686780
Central nervous system leukaemia 13.82 11.15 14 255839 250 29696375
Product dispensing error 13.81 11.15 18 255835 5871 29690754
Umbilical hernia 13.80 11.15 7 255846 3654 29692971
Panophthalmitis 13.78 11.15 6 255847 21 29696604
White blood cell count increased 13.78 11.15 247 255606 39426 29657199
Anal inflammation 13.76 11.15 16 255837 336 29696289
Retinal detachment 13.74 11.15 82 255771 4978 29691647
Central nervous system vasculitis 13.73 11.15 17 255836 382 29696243
Lip swelling 13.73 11.15 59 255794 12685 29683940
Incorrect route of product administration 13.70 11.15 50 255803 11265 29685360
Electrocardiogram Q waves 13.70 11.15 7 255846 38 29696587
Cytomegalovirus infection 13.68 11.15 281 255572 23393 29673232
Chemotherapeutic drug level increased 13.68 11.15 13 255840 214 29696411
Gastric perforation 13.66 11.15 44 255809 2037 29694588
Cardiac failure 13.62 11.15 578 255275 82840 29613785
Superior sagittal sinus thrombosis 13.58 11.15 15 255838 297 29696328
Light chain analysis abnormal 13.56 11.15 8 255845 60 29696565
Primary amyloidosis 13.56 11.15 8 255845 60 29696565
No adverse event 13.55 11.15 90 255763 17329 29679296
Neoplasm 13.54 11.15 70 255783 4026 29692599
Blood culture positive 13.54 11.15 80 255773 4839 29691786
Corneal infiltrates 13.53 11.15 13 255840 217 29696408
Colitis 13.53 11.15 352 255501 30468 29666157
Presyncope 13.50 11.15 81 255772 15975 29680650
Hip deformity 13.47 11.15 9 255844 86 29696539
Therapy cessation 13.46 11.15 75 255778 15062 29681563
Multiple sclerosis 13.45 11.15 26 255827 7241 29689384
Pallor 13.41 11.15 115 255738 20934 29675691
Hordeolum 13.40 11.15 23 255830 701 29695924
Memory impairment 13.37 11.15 230 255623 36944 29659681
Status epilepticus 13.36 11.15 49 255804 11023 29685602
Lymphocyte count decreased 13.36 11.15 233 255620 18822 29677803
Sleep disorder 13.35 11.15 139 255714 24340 29672285
Fibromyalgia 13.34 11.15 3 255850 2615 29694010
Renal tubular necrosis 13.32 11.15 76 255777 15175 29681450
Corneal deposits 13.31 11.15 12 255841 184 29696441
Steroid diabetes 13.28 11.15 32 255821 1249 29695376
Hyperlactacidaemia 13.25 11.15 3 255850 2603 29694022
Squamous cell carcinoma of head and neck 13.25 11.15 11 255842 150 29696475
Head injury 13.21 11.15 88 255765 16932 29679693
Mydriasis 13.18 11.15 20 255833 6123 29690502
Cardiogenic shock 13.18 11.15 87 255766 16774 29679851
Personality change due to a general medical condition 13.14 11.15 7 255846 42 29696583
Basosquamous carcinoma of skin 13.14 11.15 5 255848 11 29696614
Back disorder 13.12 11.15 92 255761 5902 29690723
Hyperreflexia 13.04 11.15 4 255849 2835 29693790
Hemiparesis 13.02 11.15 188 255665 14614 29682011
Hypertonia 12.98 11.15 11 255842 4374 29692251
Staphylococcal sepsis 12.94 11.15 131 255722 9360 29687265
Hyperaemia 12.93 11.15 27 255826 956 29695669
Lung infiltration 12.89 11.15 164 255689 12395 29684230
Inflammation 12.88 11.15 123 255730 21903 29674722
Plasma cells present 12.87 11.15 4 255849 3 29696622
Radiation skin injury 12.87 11.15 22 255831 668 29695957
Thrombophlebitis superficial 12.86 11.15 51 255802 2618 29694007
Aeromonas infection 12.85 11.15 14 255839 273 29696352
Concomitant disease aggravated 12.74 11.15 15 255838 5114 29691511
Atrioventricular block complete 12.71 11.15 34 255819 8443 29688182
Thinking abnormal 12.69 11.15 16 255837 5295 29691330
Granulocytopenia 12.67 11.15 21 255832 6205 29690420
Bacterial infection 12.66 11.15 164 255689 12446 29684179
Gait disturbance 12.66 11.15 516 255337 74261 29622364
Cerebral haemorrhage 12.65 11.15 201 255652 32686 29663939
Agranulocytosis 12.63 11.15 123 255730 21819 29674806
Transformation to acute myeloid leukaemia 12.59 11.15 21 255832 625 29696000
Hypokinesia 12.57 11.15 27 255826 7233 29689392
Hypercholesterolaemia 12.51 11.15 29 255824 7563 29689062
Cellulitis streptococcal 12.50 11.15 7 255846 47 29696578
Monoclonal immunoglobulin increased 12.50 11.15 7 255846 47 29696578
Metastases to meninges 12.48 11.15 30 255823 1169 29695456
Impaired work ability 12.47 11.15 18 255835 5625 29691000
POEMS syndrome 12.46 11.15 6 255847 28 29696597
Drug eruption 12.44 11.15 93 255760 17433 29679192
Dental fistula 12.43 11.15 10 255843 130 29696495
Arachnoiditis 12.43 11.15 15 255838 328 29696297
Vocal cord paresis 12.42 11.15 9 255844 99 29696526
Lower gastrointestinal haemorrhage 12.39 11.15 31 255822 7873 29688752
Recall phenomenon 12.38 11.15 20 255833 579 29696046
Microangiopathic haemolytic anaemia 12.38 11.15 24 255829 805 29695820
Keratitis bacterial 12.37 11.15 8 255845 72 29696553
Pachymeningitis 12.35 11.15 9 255844 100 29696525
Bundle branch block right 12.35 11.15 26 255827 7016 29689609
High density lipoprotein decreased 12.30 11.15 6 255847 3204 29693421
Posterior capsule rupture 12.30 11.15 5 255848 14 29696611
Hyperdynamic left ventricle 12.27 11.15 8 255845 73 29696552
Cataract cortical 12.27 11.15 8 255845 73 29696552
Leukoencephalopathy 12.27 11.15 67 255786 3935 29692690
Joint injury 12.26 11.15 24 255829 6653 29689972
Sarcoidosis 12.26 11.15 4 255849 2725 29693900
Prostate cancer stage IV 12.22 11.15 12 255841 206 29696419
Blood test abnormal 12.21 11.15 85 255768 5440 29691185
Lentigo maligna 12.19 11.15 13 255840 247 29696378
Mean cell haemoglobin increased 12.18 11.15 28 255825 1060 29695565
Haemoglobin abnormal 12.15 11.15 56 255797 3073 29693552
Platelet count abnormal 12.14 11.15 46 255807 2311 29694314
Bacillus test positive 12.13 11.15 6 255847 30 29696595
Needle issue 12.11 11.15 9 255844 3823 29692802
Syncope 12.10 11.15 597 255256 84306 29612319
Neutropenic infection 12.07 11.15 27 255826 1003 29695622
Heparin-induced thrombocytopenia 12.07 11.15 17 255836 5366 29691259
Squamous cell carcinoma of the hypopharynx 12.05 11.15 5 255848 15 29696610
Gastrointestinal wall thinning 12.05 11.15 5 255848 15 29696610
Keratitis 12.05 11.15 29 255824 1131 29695494
Restlessness 12.05 11.15 129 255724 22470 29674155
Renal tubular disorder 12.05 11.15 15 255838 4991 29691634
Atrial flutter 12.02 11.15 180 255673 14101 29682524
Central vision loss 11.98 11.15 6 255847 31 29696594
Congenital herpes simplex infection 11.92 11.15 7 255846 52 29696573
Gastrointestinal toxicity 11.88 11.15 41 255812 1967 29694658
Electrocardiogram abnormal 11.87 11.15 20 255833 5872 29690753
Recalled product administered 11.87 11.15 16 255837 392 29696233
Duodenal ulcer 11.83 11.15 44 255809 9857 29686768
Aortic aneurysm 11.82 11.15 23 255830 6390 29690235
Transient ischaemic attack 11.82 11.15 148 255705 25052 29671573
Janeway lesion 11.82 11.15 5 255848 16 29696609
Oesophageal stenosis 11.81 11.15 35 255818 1548 29695077
Cholelithiasis 11.80 11.15 113 255740 20112 29676513
Blood potassium decreased 11.77 11.15 204 255649 16458 29680167
Catatonia 11.77 11.15 12 255841 4368 29692257
Bipolar disorder 11.77 11.15 9 255844 3767 29692858
Post procedural infection 11.76 11.15 13 255840 4559 29692066
Mesenteric vascular insufficiency 11.71 11.15 7 255846 54 29696571
Diabetic hyperosmolar coma 11.68 11.15 15 255838 350 29696275
Therapy responder 11.67 11.15 11 255842 179 29696446
Pancreatitis acute 11.65 11.15 152 255701 25543 29671082
Nephrotic syndrome 11.59 11.15 26 255827 6859 29689766
Vena cava thrombosis 11.59 11.15 27 255826 1031 29695594
Orthopnoea 11.57 11.15 13 255840 4527 29692098
Expired product administered 11.56 11.15 5 255848 2864 29693761
Ventricular septal defect 11.53 11.15 8 255845 3521 29693104
Subdural haematoma 11.50 11.15 105 255748 18867 29677758
Superficial spreading melanoma stage II 11.47 11.15 4 255849 6 29696619
Lung hypoinflation 11.47 11.15 4 255849 6 29696619
Corneal disorder 11.47 11.15 23 255830 791 29695834
Aplasia pure red cell 11.43 11.15 19 255834 5607 29691018
Mantle cell lymphoma recurrent 11.42 11.15 16 255837 407 29696218
Jaw operation 11.40 11.15 13 255840 267 29696358
Subclavian vein thrombosis 11.38 11.15 24 255829 856 29695769
Cellulitis enterococcal 11.31 11.15 3 255850 0 29696625
Full blood count 11.31 11.15 3 255850 0 29696625
Fibrin increased 11.31 11.15 3 255850 0 29696625
Noninfective conjunctivitis 11.31 11.15 3 255850 0 29696625
Herpes simplex meningitis 11.31 11.15 3 255850 0 29696625
Nasal cavity mass 11.31 11.15 3 255850 0 29696625
Lung squamous cell carcinoma stage II 11.31 11.15 3 255850 0 29696625
Dystrophic calcification 11.31 11.15 3 255850 0 29696625
Adenocarcinoma of salivary gland 11.31 11.15 3 255850 0 29696625
Lymphocyte adoptive therapy 11.31 11.15 3 255850 0 29696625
Hypothyroidism 11.30 11.15 78 255775 14885 29681740
Chest wall abscess 11.30 11.15 7 255846 58 29696567
Spinal pain 11.27 11.15 71 255782 4393 29692232
Aspiration 11.27 11.15 49 255804 10502 29686123
Gingivitis 11.23 11.15 54 255799 3016 29693609
Joint swelling 11.23 11.15 310 255543 46636 29649989
Monoclonal gammopathy 11.21 11.15 13 255840 272 29696353
Coordination abnormal 11.18 11.15 29 255824 7276 29689349
Maternal drugs affecting foetus 11.15 11.15 12 255841 4261 29692364
Tumour haemorrhage 11.15 11.15 47 255806 2481 29694144

Pharmacologic Action:

SourceCodeDescription
ATC A01AC02 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Corticosteroids for local oral treatment
ATC C05AA09 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AB19 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC D07XB05 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, moderately potent, other combinations
ATC D10AA03 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Corticosteroids, combinations for treatment of acne
ATC H02AB02 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD03 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC S01BA01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01CB01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA06 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC S03BA01 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS
Corticosteroids
ATC D07CB04 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, moderately potent, combinations with antibiotics
ATC R01AD53 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC S01CA01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S02CA06 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S03CA01 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000932 Antiemetics
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressant
CHEBI has role CHEBI:37962 adrenergic neuron agents
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Otitis externa indication 3135009
Keratitis indication 5888003 DOID:4677
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Cyclitis indication 17657000
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Keloid scar indication 33659008
Crohn's disease indication 34000006
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Punctate keratitis indication 42513006 DOID:12197
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Iritis indication 65074000 DOID:1406
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Blepharoconjunctivitis indication 68659002 DOID:2456
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Perforation of cornea indication 74895004
Iridocyclitis indication 77971008
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Corneal abrasion indication 85848002
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Corneal ulcer indication 91514001 DOID:8463
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Multiple myeloma indication 109989006 DOID:9538
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Mycosis fungoides indication 118618005
Uveitis indication 128473001 DOID:13141
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Central retinal vein occlusion with macular edema indication 232039004
Branch retinal vein occlusion with macular edema indication 232048009
Malignant otitis externa due to Pseudomonas aeruginosa indication 232230009
Scalp psoriasis indication 238608008
Punctate keratopathy indication 246936005
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Infective otitis media indication 312218008
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Herpes zoster keratitis indication 397573005
Rosacea indication 398909004 DOID:8881
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Allergic otitis externa indication 405821001
Anterior uveitis indication 410692006 DOID:1407
Autoimmune hemolytic anemia indication 413603009 DOID:718
Allergic conjunctivitis indication 473460002 DOID:11204
Otitis Externa Seborrhea indication
Post-Op Ocular Inflammation indication
Otitis Externa Eczema indication
Non-infectious Posterior Uveitis indication
Progressive Diffuse Large B-Cell Lymphoma indication
Synovitis due to Osteoarthritis indication
Tuberculosis Meningitis Treatment Adjunct indication
Transfusion Reaction Urticaria indication
Erythroblastic Anemia indication
Staphylococcus Aureus Otitis Externa indication
Diagnostic Test for Cushing's Syndrome indication
Systemic Dermatomyositis indication
Pericarditis off-label use 3238004 DOID:1787
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Tendinitis off-label use 34840004 DOID:971
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Croup off-label use 71186008 DOID:9395
Pemphigoid off-label use 86142006
Myasthenia gravis off-label use 91637004 DOID:437
Polyarteritis nodosa off-label use 155441006 DOID:9810
Chemotherapy-induced nausea and vomiting off-label use 236084000
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Metastatic Prostate Carcinoma off-label use
Prevention of Radiation-Induced Nausea and Vomiting off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Prevention of Post-Operative Nausea and Vomiting off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Endophthalmitis contraindication 1847009 DOID:4692
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Herpes simplex keratitis contraindication 9389005
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Glaucoma contraindication 23986001 DOID:1686
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Severe myopia contraindication 34187009
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Retinal detachment contraindication 42059000 DOID:5327
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Bacterial infection of eye contraindication 128984004
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Injury of eye region contraindication 282752000
Varicella-zoster virus infection contraindication 309465005
Viral eye infection contraindication 312132001
Viral ear infection contraindication 312137007
Osteopenia contraindication 312894000
Vaccinia keratitis contraindication 397552005
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 12.45 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
9% DEXYCU KIT EYEPOINT PHARMS N208912 Feb. 9, 2018 RX SUSPENSION INTRAOCULAR Feb. 9, 2021 NEW PRODUCT
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC Nov. 30, 2021 NEW PRODUCT
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC June 20, 2022 TREATMENT OF OCULAR INFLAMMATION FOLLOWING OPHTHALMIC SURGERY
20MG HEMADY DEXCEL PHARMA N211379 Oct. 3, 2019 RX TABLET ORAL Oct. 3, 2026 INDICATED IN COMBINULLTION WITH OTHER ANTI-MYELOMA PRODUCTS FOR THE TREATMENT OF ADULTS WITH MULTIPLE MYELOMA (MM)

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8.88 WOMBAT-PK CHEMBL
Interleukin-5 Cytokine IC50 8.46 WOMBAT-PK
Mineralocorticoid receptor Nuclear hormone receptor EC50 9 WOMBAT-PK
Annexin A1 Cytosolic other WOMBAT-PK
Progesterone receptor Nuclear hormone receptor Ki 6.25 CHEMBL
Androgen receptor Nuclear hormone receptor Ki 5.85 CHEMBL
Prostaglandin G/H synthase 2 Enzyme Ki 6.89 PDSP
Interleukin-4 Cytokine IC50 8.33 WOMBAT-PK
Androgen receptor Transcription factor Ki 4.79 DRUG MATRIX
Progesterone receptor Transcription factor Ki 5.52 DRUG MATRIX
Fatty acid-binding protein, liver Unclassified Ki 4.66 CHEMBL
Glucocorticoid receptor Transcription factor IC50 7.66 CHEMBL
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor AGONIST EC50 6.10 IUPHAR

External reference:

IDSource
4017922 VUID
N0000146273 NUI
D00292 KEGG_DRUG
4017922 VANDF
C0011777 UMLSCUI
CHEBI:41879 CHEBI
DEX PDB_CHEM_ID
CHEMBL384467 ChEMBL_ID
CHEMBL1200637 ChEMBL_ID
CHEMBL2021430 ChEMBL_ID
DB01234 DRUGBANK_ID
D003907 MESH_DESCRIPTOR_UI
5743 PUBCHEM_CID
2768 IUPHAR_LIGAND_ID
816 INN_ID
7S5I7G3JQL UNII
203704 RXNORM
4552 MMSL
6848 MMSL
6849 MMSL
d00206 MMSL
002174 NDDF
372584003 SNOMEDCT_US
7561000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
OZURDEX HUMAN PRESCRIPTION DRUG LABEL 1 0023-3348 IMPLANT 0.70 mg INTRAVITREAL NDA 24 sections
Dexamethasone Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3176 SOLUTION, CONCENTRATE 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-3177 SOLUTION 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4179 TABLET 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4180 TABLET 0.75 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4181 TABLET 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4182 TABLET 1.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4183 TABLET 2 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4184 TABLET 4 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4186 TABLET 6 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8174 TABLET 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8175 TABLET 4 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8176 TABLET 2 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8179 TABLET 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8180 TABLET 0.75 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8181 TABLET 1.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8183 TABLET 6 mg ORAL ANDA 20 sections
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0065-0631 OINTMENT 1 mg OPHTHALMIC NDA 18 sections
TobraDex HUMAN PRESCRIPTION DRUG LABEL 2 0065-0647 SUSPENSION/ DROPS 1 mg OPHTHALMIC NDA 18 sections
TobraDex HUMAN PRESCRIPTION DRUG LABEL 2 0065-0648 OINTMENT 1 mg OPHTHALMIC NDA 18 sections
TOBRADEX ST HUMAN PRESCRIPTION DRUG LABEL 2 0065-0652 SUSPENSION/ DROPS 0.50 mg OPHTHALMIC NDA 21 sections
CIPRODEX HUMAN PRESCRIPTION DRUG LABEL 2 0065-8533 SUSPENSION/ DROPS 1 mg AURICULAR (OTIC) NDA 27 sections
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0078-0771 OINTMENT 1 mg OPHTHALMIC NDA 18 sections
CIPRODEX HUMAN PRESCRIPTION DRUG LABEL 2 0078-0799 SUSPENSION/ DROPS 1 mg AURICULAR (OTIC) NDA 28 sections
TobraDex HUMAN PRESCRIPTION DRUG LABEL 2 0078-0876 OINTMENT 1 mg OPHTHALMIC NDA 18 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0095-0087 TABLET 1.50 mg ORAL ANDA 23 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0095-0088 TABLET 1.50 mg ORAL ANDA 23 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0095-0089 TABLET 1.50 mg ORAL ANDA 23 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0121-0907 SOLUTION 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0121-1814 SOLUTION 1 mg ORAL ANDA 20 sections