dexamethasone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 824 50-02-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexamethasone
  • dexasone
  • dexmethsone
An anti-inflammatory 9-fluoro-glucocorticoid. The NIH COVID-19 Treatment Guidelines Panel recommends the use of dexamethasone in patients with COVID-19 who are receiving mechanical ventilation or in those who require supplemental oxygen but are not on me-chanical ventilation. It is not recommended the use of dexamethasone or other corticosteroids in nonhospitalized patients with mild to moderate COVID-19 or in hospitalized patients with COVID-19 who do not require supplemental oxygen.
  • Molecular weight: 392.47
  • Formula: C22H29FO5
  • CLOGP: 1.78
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.89
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 mg O
1.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.08 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 2.60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.33 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.94 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.32 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 25, 2021 PMDA NICHI - IKO PHARMACEUTICAL Co., Ltd.
Oct. 30, 1958 FDA
July 26, 2010 EMA AbbVie Deutschland GmbH & Co. KG

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 2646.05 10.38 1867 323768 34038 63129349
Neutropenia 2135.34 10.38 3474 322161 171531 62991856
Neuropathy peripheral 2047.03 10.38 2712 322923 110955 63052432
Febrile neutropenia 1748.64 10.38 2569 323066 115880 63047507
Thrombocytopenia 1671.05 10.38 2872 322763 148285 63015102
Disease progression 989.69 10.38 2039 323596 120719 63042668
Diarrhoea 948.56 10.38 6585 319050 708781 62454606
Rheumatoid arthritis 808.43 10.38 160 325475 253659 62909728
Death 737.43 10.38 3826 321809 370555 62792832
Pneumonia 677.29 10.38 4328 321307 452439 62710948
Platelet count decreased 669.99 10.38 1690 323945 114432 63048955
Systemic lupus erythematosus 662.39 10.38 133 325502 208785 62954602
Completed suicide 651.96 10.38 21 325614 145652 63017735
Constipation 624.35 10.38 2544 323091 222399 62940988
Pemphigus 594.98 10.38 111 325524 183615 62979772
Plasma cell myeloma recurrent 590.01 10.38 301 325334 2912 63160475
Contraindicated product administered 570.28 10.38 202 325433 217446 62945941
Pain 557.72 10.38 1944 323691 738684 62424703
Neutrophil count decreased 544.08 10.38 1011 324624 55395 63107992
Drug ineffective 530.84 10.38 3172 322463 1041593 62121794
Pancytopenia 528.25 10.38 1381 324254 95552 63067835
White blood cell count decreased 528.10 10.38 1742 323893 137362 63026025
Arthralgia 518.03 10.38 1370 324265 568340 62595047
Anaemia 512.81 10.38 2904 322731 290526 62872861
Hand deformity 491.98 10.38 108 325527 159349 63004038
Therapeutic product effect decreased 488.05 10.38 190 325445 192997 62970390
Sepsis 480.69 10.38 1801 323834 151322 63012065
Arthropathy 469.38 10.38 314 325321 234478 62928909
Full blood count decreased 466.03 10.38 620 325015 25404 63137983
Glossodynia 433.85 10.38 187 325448 178689 62984698
Synovitis 430.69 10.38 210 325425 186708 62976679
Mucosal inflammation 428.81 10.38 822 324813 46106 63117281
Abdominal discomfort 423.13 10.38 619 325016 320266 62843121
Drug hypersensitivity 413.89 10.38 595 325040 310092 62853295
Leukopenia 400.57 10.38 1081 324554 76209 63087178
Joint swelling 391.43 10.38 675 324960 326991 62836396
Off label use 389.29 10.38 5214 320421 669248 62494139
Injection site pain 374.77 10.38 101 325534 129699 63033688
Cytopenia 365.83 10.38 370 325265 11231 63152156
Plasmacytoma 364.66 10.38 203 325432 2376 63161011
Deep vein thrombosis 360.44 10.38 1096 324539 82704 63080683
Anti-cyclic citrullinated peptide antibody positive 349.82 10.38 83 325552 116129 63047258
Swelling 348.63 10.38 546 325089 274832 62888555
Pericarditis 346.37 10.38 121 325514 131458 63031929
Condition aggravated 336.94 10.38 1005 324630 401212 62762175
Thrombosis 332.81 10.38 903 324732 63852 63099535
Wound 322.56 10.38 221 325414 163042 63000345
Musculoskeletal stiffness 315.59 10.38 289 325346 184329 62979058
Neutropenic sepsis 311.93 10.38 403 325232 16035 63147352
Intentional overdose 310.70 10.38 17 325618 74135 63089252
Septic shock 294.55 10.38 880 324755 65749 63097638
Psoriasis 286.83 10.38 50 325585 86907 63076480
Hepatic enzyme increased 280.69 10.38 376 325259 201952 62961435
Polyneuropathy 278.92 10.38 359 325276 14230 63149157
Unevaluable event 270.49 10.38 723 324912 50663 63112724
Pulmonary embolism 266.09 10.38 1245 324390 115439 63047948
Treatment failure 265.00 10.38 381 325254 198662 62964725
Malignant neoplasm progression 261.66 10.38 971 324664 81150 63082237
Discomfort 256.41 10.38 288 325347 167086 62996301
Psoriatic arthropathy 248.08 10.38 80 325555 91440 63071947
Tumour lysis syndrome 246.34 10.38 266 325369 8724 63154663
Overdose 241.99 10.38 145 325490 114933 63048454
Laboratory test abnormal 239.18 10.38 466 325169 26446 63136941
Headache 238.61 10.38 2090 323545 631151 62532236
Drug abuse 236.34 10.38 43 325592 72475 63090912
Drug intolerance 233.95 10.38 806 324829 307855 62855532
Rheumatoid factor positive 230.17 10.38 73 325562 84333 63079054
Posterior reversible encephalopathy syndrome 223.97 10.38 354 325281 16991 63146396
Peripheral sensory neuropathy 221.08 10.38 230 325405 7221 63156166
Febrile bone marrow aplasia 220.74 10.38 228 325407 7097 63156290
Helicobacter infection 218.55 10.38 101 325534 92684 63070703
Asthenia 217.14 10.38 2958 322677 380646 62782741
Therapy partial responder 209.62 10.38 266 325369 10392 63152995
Pyrexia 208.23 10.38 3478 322157 467000 62696387
Suicide attempt 207.65 10.38 32 325603 60886 63102501
Injection site erythema 203.05 10.38 86 325549 83088 63080299
Mobility decreased 197.24 10.38 198 325437 120961 63042426
Loss of personal independence in daily activities 195.70 10.38 129 325506 97161 63066226
Cytokine release syndrome 187.40 10.38 294 325341 14020 63149367
Bone marrow failure 179.97 10.38 437 325198 28853 63134534
Flushing 179.86 10.38 813 324822 74274 63089113
Plasma cell leukaemia 179.30 10.38 96 325539 1034 63162353
Light chain analysis increased 177.82 10.38 101 325534 1232 63162155
Irritable bowel syndrome 168.85 10.38 107 325528 82305 63081082
Haematotoxicity 168.78 10.38 224 325411 9152 63154235
Muscle injury 166.97 10.38 63 325572 65282 63098105
Duodenal ulcer perforation 166.96 10.38 122 325513 87087 63076300
Multiple sclerosis relapse 159.57 10.38 28 325607 48450 63114937
Injection site reaction 158.87 10.38 51 325584 58473 63104914
Dehydration 158.22 10.38 1469 324166 171885 62991502
Knee arthroplasty 156.73 10.38 42 325593 54164 63109223
Abortion spontaneous 155.91 10.38 27 325608 47168 63116219
Bone pain 154.32 10.38 622 325013 54019 63109368
Maternal exposure during pregnancy 153.18 10.38 595 325040 219467 62943920
Impaired healing 153.12 10.38 180 325455 102362 63061025
Therapeutic product effect incomplete 149.59 10.38 257 325378 124799 63038588
Osteoarthritis 149.31 10.38 161 325474 95182 63068205
Venoocclusive liver disease 148.41 10.38 152 325483 4683 63158704
Pneumocystis jirovecii pneumonia 145.59 10.38 289 325346 16625 63146762
COVID-19 pneumonia 144.90 10.38 261 325374 13948 63149439
Osteonecrosis 144.37 10.38 360 325275 24170 63139217
Fatigue 142.68 10.38 5732 319903 882296 62281091
Sinusitis 140.33 10.38 641 324994 226012 62937375
Diffuse large B-cell lymphoma recurrent 137.73 10.38 106 325529 2214 63161173
Endophthalmitis 136.62 10.38 127 325508 3465 63159922
Suicidal ideation 136.40 10.38 75 325560 62346 63101041
Injection site pruritus 136.15 10.38 32 325603 45084 63118303
Sleep disorder due to general medical condition, insomnia type 135.67 10.38 49 325586 52168 63111219
Alopecia 135.26 10.38 1095 324540 336441 62826946
Injection site swelling 133.55 10.38 39 325596 47533 63115854
Injection site bruising 132.00 10.38 27 325608 41883 63121504
Pneumonitis 131.55 10.38 439 325196 34783 63128604
Monoclonal immunoglobulin present 131.40 10.38 71 325564 780 63162607
Blister 130.89 10.38 295 325340 129519 63033868
Folliculitis 129.94 10.38 102 325533 70215 63093172
Haemophagocytic lymphohistiocytosis 126.44 10.38 209 325426 10418 63152969
Metastases to central nervous system 126.40 10.38 235 325400 12870 63150517
Migraine 125.78 10.38 210 325425 103136 63060251
Neurotoxicity 124.80 10.38 272 325363 16718 63146669
Hyperglycaemia 121.75 10.38 481 325154 41386 63122001
Hepatitis B reactivation 121.42 10.38 112 325523 3025 63160362
Multiple organ dysfunction syndrome 114.55 10.38 585 325050 56167 63107220
Arthritis 113.97 10.38 267 325368 115654 63047733
Plasma cell myeloma refractory 113.63 10.38 49 325586 310 63163077
Asthma 112.89 10.38 310 325325 127251 63036136
Decreased appetite 112.19 10.38 1860 323775 249192 62914195
Product use issue 111.60 10.38 668 324967 219852 62943535
Bronchopulmonary aspergillosis 111.15 10.38 176 325459 8459 63154928
Hip arthroplasty 110.43 10.38 53 325582 47593 63115794
Intentional self-injury 110.42 10.38 5 325630 25682 63137705
Myelodysplastic syndrome 108.34 10.38 255 325380 16499 63146888
Acute lymphocytic leukaemia recurrent 107.80 10.38 91 325544 2178 63161209
Depression 107.64 10.38 580 325055 195912 62967475
Hypokalaemia 105.63 10.38 901 324734 102903 63060484
Stress 105.62 10.38 113 325522 67054 63096333
Anaphylactic shock 103.31 10.38 311 325324 23322 63140065
Pain in extremity 103.01 10.38 1145 324490 330341 62833046
Intentional product misuse 102.05 10.38 97 325538 60820 63102567
Fibromyalgia 102.00 10.38 159 325476 80261 63083126
Wrong technique in product usage process 101.28 10.38 102 325533 62238 63101149
Respiratory failure 99.41 10.38 876 324759 100982 63062405
Osteolysis 98.63 10.38 96 325539 2778 63160609
Inappropriate schedule of product administration 97.05 10.38 246 325389 103719 63059668
Ill-defined disorder 96.84 10.38 169 325466 81586 63081801
Lymphopenia 96.54 10.38 258 325377 18069 63145318
Dysgeusia 96.02 10.38 484 325151 46226 63117161
Mucormycosis 94.99 10.38 94 325541 2777 63160610
Injury 94.64 10.38 143 325492 73104 63090283
Hospitalisation 91.86 10.38 186 325449 84895 63078492
Cardiac amyloidosis 90.48 10.38 55 325580 767 63162620
Blood potassium decreased 89.60 10.38 440 325195 41586 63121801
Corneal oedema 88.16 10.38 68 325567 1425 63161962
Ageusia 86.66 10.38 207 325428 13521 63149866
Ejection fraction decreased 84.86 10.38 280 325355 22052 63141335
Surgery 84.68 10.38 39 325596 35873 63127514
Drug withdrawal syndrome 84.65 10.38 18 325617 27176 63136211
Cytomegalovirus infection 83.50 10.38 267 325368 20685 63142702
Hypoxia 83.38 10.38 559 325076 59233 63104154
Corneal decompensation 82.08 10.38 24 325611 33 63163354
Nausea 82.04 10.38 5251 320384 849220 62314167
Acute lymphocytic leukaemia 80.70 10.38 81 325554 2435 63160952
Aspergillus infection 80.41 10.38 147 325488 7946 63155441
Systemic candida 78.55 10.38 90 325545 3155 63160232
Premature delivery 77.88 10.38 335 325300 29946 63133441
Blood pressure fluctuation 77.29 10.38 74 325561 46243 63117144
Back pain 76.57 10.38 1834 323801 262311 62901076
Type 2 diabetes mellitus 76.57 10.38 131 325504 63737 63099650
Clostridium difficile colitis 76.47 10.38 256 325379 20313 63143074
Sleep apnoea syndrome 76.25 10.38 27 325608 29106 63134281
Fall 74.97 10.38 1490 324145 390844 62772543
Incorrect dose administered 74.68 10.38 120 325515 59848 63103539
Haemoglobin decreased 74.45 10.38 1103 324532 144382 63019005
Myelosuppression 74.38 10.38 279 325356 23424 63139963
Foot deformity 74.31 10.38 25 325610 27828 63135559
Myocardial infarction 74.06 10.38 263 325372 99630 63063757
Blood pressure systolic increased 73.12 10.38 81 325554 47316 63116071
Bacteraemia 72.74 10.38 225 325410 17123 63146264
Pathological fracture 72.51 10.38 148 325487 8686 63154701
Drug interaction 71.28 10.38 791 324844 228340 62935047
Renal failure 71.16 10.38 919 324716 116733 63046654
Gait disturbance 71.08 10.38 599 325036 182579 62980808
Accidental exposure to product 70.70 10.38 26 325609 27379 63136008
Rhinovirus infection 70.68 10.38 101 325534 4428 63158959
Cytomegalovirus infection reactivation 70.29 10.38 94 325541 3869 63159518
Weight increased 69.85 10.38 930 324705 259862 62903525
Rhinocerebral mucormycosis 69.59 10.38 38 325597 427 63162960
Palmar-plantar erythrodysaesthesia syndrome 69.00 10.38 267 325368 22748 63140639
Febrile infection 68.99 10.38 60 325575 1497 63161890
Pneumonia influenzal 68.44 10.38 62 325573 1635 63161752
Red blood cell sedimentation rate increased 68.03 10.38 75 325560 43907 63119480
Neutrophil count abnormal 67.97 10.38 79 325556 2813 63160574
Hypoglycaemia 67.70 10.38 128 325507 59937 63103450
Strongyloidiasis 67.56 10.38 54 325581 1194 63162193
Hypertriglyceridaemia 66.42 10.38 117 325518 6142 63157245
Eastern Cooperative Oncology Group performance status worsened 65.21 10.38 53 325582 1201 63162186
Neoplasm progression 64.98 10.38 363 325272 36065 63127322
Impaired work ability 64.79 10.38 7 325628 17468 63145919
Pulmonary thrombosis 64.69 10.38 140 325495 8562 63154825
Hypercholesterolaemia 64.63 10.38 15 325620 21319 63142068
Vasogenic cerebral oedema 64.56 10.38 46 325589 850 63162537
Injection site haemorrhage 64.55 10.38 22 325613 24292 63139095
Coma 64.25 10.38 147 325488 64217 63099170
Bronchospasm 64.18 10.38 215 325420 17065 63146322
Red blood cell sedimentation rate abnormal 63.86 10.38 12 325623 19770 63143617
Joint range of motion decreased 63.84 10.38 44 325591 32384 63131003
Colitis ulcerative 63.62 10.38 27 325608 26064 63137323
Coronary artery disease 62.33 10.38 45 325590 32332 63131055
Osteoporosis 62.19 10.38 125 325510 57213 63106174
Erythema 61.91 10.38 1255 324380 174496 62988891
Immune effector cell-associated neurotoxicity syndrome 61.73 10.38 67 325568 2210 63161177
Respiratory syncytial virus infection 61.71 10.38 121 325514 6897 63156490
C-reactive protein abnormal 61.49 10.38 88 325547 46008 63117379
Sedation 61.33 10.38 65 325570 38744 63124643
Substance-induced psychotic disorder 61.09 10.38 62 325573 1889 63161498
Bone erosion 61.07 10.38 9 325626 17708 63145679
Rheumatic fever 60.84 10.38 79 325556 43032 63120355
Contusion 60.32 10.38 486 325149 149558 63013829
Large intestine perforation 60.27 10.38 134 325501 8348 63155039
Multiple sclerosis 59.78 10.38 25 325610 24347 63139040
Aplasia 59.28 10.38 90 325545 4169 63159218
Colitis 59.07 10.38 439 325196 48089 63115298
Product quality issue 59.03 10.38 58 325577 35807 63127580
Wheezing 58.70 10.38 271 325364 95324 63068063
Tenosynovitis 58.28 10.38 3 325632 13792 63149595
Escherichia bacteraemia 56.82 10.38 84 325551 3799 63159588
Pregnancy 56.77 10.38 63 325572 36773 63126614
Obesity 55.89 10.38 43 325592 29909 63133478
Blood cholesterol increased 55.73 10.38 270 325365 93762 63069625
Muscle spasticity 55.68 10.38 21 325614 21773 63141614
Candida infection 55.63 10.38 290 325345 28061 63135326
Blood pressure diastolic decreased 54.56 10.38 24 325611 22682 63140705
Protein total increased 54.12 10.38 69 325566 2708 63160679
Pneumonia fungal 54.09 10.38 99 325536 5356 63158031
Sleep disorder 53.86 10.38 225 325410 81341 63082046
Bone lesion 53.67 10.38 103 325532 5778 63157609
Weight fluctuation 53.51 10.38 140 325495 9679 63153708
Blood pressure diastolic abnormal 53.47 10.38 6 325629 14536 63148851
Coeliac disease 53.39 10.38 3 325632 12794 63150593
Computerised tomogram thorax abnormal 53.34 10.38 55 325580 1708 63161679
Carpal tunnel syndrome 53.28 10.38 20 325615 20797 63142590
Muscle spasms 52.03 10.38 1106 324529 155044 63008343
Joint stiffness 51.93 10.38 84 325551 41785 63121602
Injection site warmth 51.73 10.38 8 325627 15187 63148200
Neutropenic colitis 51.24 10.38 71 325564 3024 63160363
COVID-19 51.17 10.38 840 324795 112263 63051124
Nasopharyngitis 51.12 10.38 957 324678 253300 62910087
Injection site mass 51.08 10.38 16 325619 18640 63144747
Atrial fibrillation 50.85 10.38 861 324774 115775 63047612
Liver injury 50.64 10.38 151 325484 60369 63103018
Product complaint 50.51 10.38 4 325631 12805 63150582
Brain stem glioma 50.46 10.38 23 325612 169 63163218
Hypersensitivity 50.43 10.38 1130 324505 291555 62871832
Herpes simplex encephalitis 50.05 10.38 28 325607 331 63163056
Lupus-like syndrome 49.97 10.38 9 325626 15286 63148101
Swollen joint count increased 49.92 10.38 67 325568 35987 63127400
Taste disorder 49.87 10.38 169 325466 13493 63149894
Hypofibrinogenaemia 49.66 10.38 44 325591 1126 63162261
Laryngospasm 49.43 10.38 69 325566 2959 63160428
Therapeutic response shortened 48.94 10.38 3 325632 11885 63151502
Injection site urticaria 48.85 10.38 7 325628 14066 63149321
Dyspnoea 48.65 10.38 3979 321656 657334 62506053
Device issue 48.52 10.38 31 325604 23750 63139637
Brain abscess 48.35 10.38 57 325578 2061 63161326
Brain oedema 47.83 10.38 171 325464 14024 63149363
Hyperviscosity syndrome 47.66 10.38 22 325613 167 63163220
Cataract 47.29 10.38 474 325161 56579 63106808
Computerised tomogram thorax 46.76 10.38 29 325606 420 63162967
Pulmonary arterial hypertension 46.66 10.38 29 325606 22548 63140839
Nasal congestion 46.60 10.38 176 325459 65484 63097903
Peripheral motor neuropathy 46.51 10.38 50 325585 1631 63161756
Embolism 46.48 10.38 116 325519 7790 63155597
Sedation complication 45.45 10.38 8 325627 13814 63149573
Disseminated intravascular coagulation 45.38 10.38 206 325429 18845 63144542
Human chorionic gonadotropin increased 45.37 10.38 48 325587 1537 63161850
Vomiting 45.20 10.38 3392 322243 556225 62607162
Nephrolithiasis 45.12 10.38 92 325543 41892 63121495
Primary amyloidosis 44.89 10.38 15 325620 40 63163347
Drug ineffective for unapproved indication 44.83 10.38 314 325321 33749 63129638
Pneumonia pneumococcal 44.69 10.38 56 325579 2159 63161228
Product use in unapproved indication 44.39 10.38 1218 324417 177862 62985525
Influenza like illness 44.32 10.38 184 325451 66640 63096747
Therapy non-responder 44.25 10.38 589 325046 75312 63088075
International normalised ratio increased 43.97 10.38 109 325526 46316 63117071
Withdrawal syndrome 43.72 10.38 24 325611 19973 63143414
Cardiotoxicity 43.64 10.38 118 325517 8320 63155067
Injection site rash 43.46 10.38 21 325614 18788 63144599
Osteonecrosis of jaw 43.46 10.38 319 325316 34804 63128583
Blood pressure increased 43.32 10.38 578 325057 161484 63001903
Lacrimation increased 43.26 10.38 215 325420 20416 63142971
Chronic obstructive pulmonary disease 43.22 10.38 170 325465 62516 63100871
Palpitations 43.16 10.38 370 325265 112400 63050987
Dry skin 43.07 10.38 464 325171 56423 63106964
Macular degeneration 42.99 10.38 37 325598 24339 63139048
Eczema 42.72 10.38 62 325573 32229 63131158
Ileus 42.66 10.38 169 325466 14556 63148831
Joint effusion 42.66 10.38 17 325618 17043 63146344
Venous thrombosis 42.47 10.38 84 325551 4818 63158569
Sopor 42.41 10.38 31 325604 22133 63141254
Inflammation 42.21 10.38 248 325387 82025 63081362
Ankylosing spondylitis 42.07 10.38 3 325632 10471 63152916
Intestinal perforation 41.93 10.38 146 325489 11817 63151570
Lactic acidosis 41.92 10.38 83 325552 38204 63125183
Hypocalcaemia 41.54 10.38 292 325343 31421 63131966
Haemoglobin abnormal 41.47 10.38 85 325550 5003 63158384
Premature baby 41.31 10.38 213 325422 20522 63142865
Pleural effusion 40.96 10.38 689 324946 92521 63070866
Intraocular pressure increased 40.93 10.38 94 325541 5984 63157403
Breast cancer metastatic 40.69 10.38 145 325490 11873 63151514
Cytomegalovirus chorioretinitis 40.51 10.38 48 325587 1745 63161642
Vitreous haemorrhage 40.05 10.38 51 325584 1999 63161388
Musculoskeletal pain 39.36 10.38 294 325341 91983 63071404
Paraesthesia 39.29 10.38 1069 324566 155897 63007490
Crying 39.29 10.38 37 325598 23306 63140081
Full blood count increased 39.28 10.38 37 325598 1027 63162360
Rhabdomyolysis 38.71 10.38 107 325528 43844 63119543
Blood lactate dehydrogenase abnormal 38.50 10.38 24 325611 351 63163036
Hepatic cirrhosis 38.44 10.38 42 325593 24692 63138695
Neutropenic infection 38.42 10.38 41 325594 1326 63162061
Hypercalcaemia 38.40 10.38 263 325372 28059 63135328
Prescribed overdose 38.29 10.38 73 325562 34080 63129307
Exostosis 38.24 10.38 22 325613 17840 63145547
Aplastic anaemia 38.18 10.38 122 325513 9447 63153940
Blood lactate dehydrogenase increased 37.73 10.38 225 325410 22891 63140496
Procedural pain 37.72 10.38 33 325602 21536 63141851
Therapy interrupted 37.60 10.38 68 325567 32387 63131000
Labelled drug-drug interaction medication error 37.57 10.38 11 325624 13388 63149999
B precursor type acute leukaemia 37.55 10.38 20 325615 213 63163174
Treatment noncompliance 37.44 10.38 85 325550 37240 63126147
Respiratory distress 37.35 10.38 300 325335 33651 63129736
Amyloidosis 37.25 10.38 37 325598 1098 63162289
Product storage error 37.24 10.38 15 325620 14941 63148446
Clostridium difficile infection 37.16 10.38 272 325363 29650 63133737
Squamous cell carcinoma of skin 37.14 10.38 91 325544 6041 63157346
Body height decreased 37.08 10.38 125 325510 9953 63153434
Hypogammaglobulinaemia 36.95 10.38 100 325535 7055 63156332
Shock 36.78 10.38 226 325409 23237 63140150
Ulcer 36.67 10.38 48 325587 26059 63137328
Bursitis 36.64 10.38 85 325550 36956 63126431
Panniculitis 36.55 10.38 7 325628 11378 63152009
B-cell type acute leukaemia 36.53 10.38 19 325616 192 63163195
Parainfluenzae virus infection 36.47 10.38 52 325583 2275 63161112
Pneumatosis intestinalis 36.47 10.38 53 325582 2360 63161027
Breast cancer female 36.47 10.38 12 325623 13547 63149840
Acute respiratory distress syndrome 36.47 10.38 226 325409 23308 63140079
Human bocavirus infection 36.38 10.38 24 325611 389 63162998
Tooth disorder 36.14 10.38 258 325377 27899 63135488
Mitochondrial DNA mutation 35.91 10.38 24 325611 398 63162989
Frequent bowel movements 35.89 10.38 39 325596 22983 63140404
Impaired quality of life 35.68 10.38 13 325622 13770 63149617
Exposure during pregnancy 35.56 10.38 572 325063 154975 63008412
Peripheral sensorimotor neuropathy 35.23 10.38 41 325594 1462 63161925
Leukoencephalopathy 35.12 10.38 73 325562 4340 63159047
Epistaxis 35.09 10.38 546 325089 72179 63091208
Joint dislocation 35.06 10.38 27 325608 18773 63144614
Feeling hot 35.06 10.38 404 325231 49950 63113437
Poor venous access 34.94 10.38 16 325619 14769 63148618
Cryptococcosis 34.84 10.38 36 325599 1121 63162266
Diffuse large B-cell lymphoma refractory 34.76 10.38 37 325598 1193 63162194
Salmonella sepsis 34.72 10.38 20 325615 251 63163136
Spinal cord compression 34.65 10.38 70 325565 4078 63159309
Meningitis listeria 34.58 10.38 28 325607 631 63162756
Hyperbilirubinaemia 34.52 10.38 132 325503 11182 63152205
Chorioretinopathy 34.52 10.38 31 325604 808 63162579
Acute kidney injury 34.51 10.38 1667 323968 261748 62901639
Pulmonary fibrosis 34.26 10.38 98 325537 39711 63123676
Bone density decreased 34.24 10.38 16 325619 14596 63148791
Underdose 34.12 10.38 55 325580 27401 63135986
Infective pulmonary exacerbation of cystic fibrosis 34.09 10.38 3 325632 8814 63154573
Acute myeloid leukaemia 34.06 10.38 176 325459 16971 63146416
Propofol infusion syndrome 34.04 10.38 33 325602 950 63162437
Blood pressure systolic abnormal 34.03 10.38 13 325622 13373 63150014
Jugular vein thrombosis 34.02 10.38 59 325576 3059 63160328
Eosinophilia 33.89 10.38 40 325595 22716 63140671
Lower respiratory tract infection 33.87 10.38 476 325159 131831 63031556
Pseudomonal sepsis 33.79 10.38 51 325584 2350 63161037
Light chain analysis abnormal 33.72 10.38 17 325618 160 63163227
Neuroleptic malignant syndrome 33.62 10.38 10 325625 12046 63151341
Refractory cytopenia with multilineage dysplasia 33.53 10.38 16 325619 132 63163255
Pulmonary mucormycosis 33.40 10.38 21 325614 312 63163075
Cholecystectomy 33.37 10.38 7 325628 10670 63152717
Product prescribing error 33.30 10.38 52 325583 26237 63137150
Platelet count abnormal 33.29 10.38 61 325574 3303 63160084
Enthesopathy 33.12 10.38 3 325632 8611 63154776
Acute interstitial pneumonitis 32.96 10.38 28 325607 676 63162711
Gastrointestinal perforation 32.92 10.38 62 325573 3429 63159958
Blood culture positive 32.74 10.38 74 325561 4661 63158726
Stridor 32.68 10.38 62 325573 3448 63159939
Glioblastoma 32.62 10.38 30 325605 807 63162580
Pneumonia cytomegaloviral 32.55 10.38 48 325587 2166 63161221
Somnolence 32.44 10.38 684 324951 178001 62985386
Enterobacter infection 32.34 10.38 48 325587 2179 63161208
Low birth weight baby 32.28 10.38 95 325540 7034 63156353
Blood fibrinogen decreased 32.14 10.38 30 325605 823 63162564
Poisoning 32.11 10.38 15 325620 13685 63149702
White blood cell count abnormal 31.99 10.38 87 325548 6155 63157232
Hyperaemia 31.81 10.38 48 325587 2211 63161176
Chronic sinusitis 31.78 10.38 13 325622 12830 63150557
Disease recurrence 31.55 10.38 249 325386 27781 63135606
Tremor 31.51 10.38 895 324740 131344 63032043
Pseudomonas test positive 31.49 10.38 28 325607 720 63162667
Radiation skin injury 31.43 10.38 31 325604 912 63162475
Iris atrophy 31.28 10.38 13 325622 74 63163313
Adrenogenital syndrome 31.27 10.38 11 325624 36 63163351
Myalgia 31.16 10.38 546 325089 145983 63017404
Oral candidiasis 31.09 10.38 212 325423 22586 63140801
Coombs indirect test positive 31.04 10.38 11 325624 37 63163350
Respiratory tract infection 30.77 10.38 337 325298 41146 63122241
Nocardiosis 30.74 10.38 44 325591 1932 63161455
Anxiety 30.66 10.38 865 324770 216676 62946711
Performance status decreased 30.64 10.38 62 325573 3616 63159771
Foot fracture 30.58 10.38 47 325588 23867 63139520
Escherichia infection 30.44 10.38 138 325497 12616 63150771
Deformity 30.28 10.38 11 325624 11673 63151714
Enterocolitis 30.28 10.38 99 325536 7759 63155628
Drug tolerance decreased 30.23 10.38 27 325608 17446 63145941
Cardiopulmonary failure 30.22 10.38 61 325574 3551 63159836
Paraproteinaemia 30.15 10.38 16 325619 169 63163218
Staphylococcal sepsis 30.07 10.38 101 325534 8027 63155360
Hiatus hernia 30.03 10.38 40 325595 21554 63141833
Gastrointestinal fungal infection 30.01 10.38 20 325615 330 63163057
Pupillary deformity 29.95 10.38 7 325628 0 63163387
Alopecia areata 29.93 10.38 40 325595 1645 63161742
Iron deficiency anaemia 29.85 10.38 35 325600 19934 63143453
Skin discolouration 29.78 10.38 311 325324 37517 63125870
Accidental overdose 29.63 10.38 46 325589 23263 63140124
Ovarian cyst 29.61 10.38 23 325612 15922 63147465
Perineal necrosis 29.60 10.38 14 325621 113 63163274
Electrolyte imbalance 29.37 10.38 190 325445 19886 63143501
Intentional product use issue 29.33 10.38 470 325165 127422 63035965
Urticaria 29.13 10.38 638 324997 165164 62998223
Corneal disorder 29.11 10.38 41 325594 1773 63161614
Food allergy 29.10 10.38 11 325624 11390 63151997
Adrenal insufficiency 29.00 10.38 174 325461 17741 63145646
Spinal operation 28.98 10.38 4 325631 8267 63155120
Heavy menstrual bleeding 28.95 10.38 29 325606 17744 63145643
Ascites 28.91 10.38 328 325307 40400 63122987
Fusarium infection 28.84 10.38 25 325610 621 63162766
Depressed level of consciousness 28.80 10.38 193 325442 61885 63101502
Heart block congenital 28.72 10.38 8 325627 8 63163379
Prescribed underdose 28.67 10.38 69 325566 29620 63133767
Malaise 28.56 10.38 1795 323840 414159 62749228
Klebsiella bacteraemia 28.54 10.38 39 325596 1639 63161748
Pneumonia bacterial 28.53 10.38 110 325525 9355 63154032
Parkinsonism 28.50 10.38 9 325626 10430 63152957
Acute respiratory failure 28.33 10.38 286 325349 34199 63129188
Device malfunction 28.11 10.38 30 325605 17827 63145560
Metastases to meninges 28.08 10.38 49 325586 2553 63160834
Hypopyon 28.07 10.38 26 325609 706 63162681
JC virus infection 28.06 10.38 43 325592 2008 63161379
Device breakage 28.05 10.38 12 325623 11530 63151857
Right ventricular failure 28.05 10.38 28 325607 17160 63146227
Central nervous system leukaemia 28.02 10.38 14 325621 129 63163258
Infusion related reaction 27.93 10.38 1004 324631 244517 62918870
Body dysmorphic disorder 27.92 10.38 19 325616 325 63163062
Sleep disorder due to a general medical condition 27.57 10.38 14 325621 12174 63151213
Colitis microscopic 27.44 10.38 7 325628 9332 63154055
Herpes simplex oesophagitis 27.36 10.38 15 325620 170 63163217
Thrombotic microangiopathy 27.28 10.38 117 325518 10444 63152943
Pruritus 27.26 10.38 1546 324089 359907 62803480
Human herpesvirus 6 infection 27.24 10.38 52 325583 2905 63160482
Perineal infection 27.21 10.38 14 325621 138 63163249
Chalazion 27.07 10.38 20 325615 392 63162995
Glycosylated haemoglobin increased 26.93 10.38 15 325620 12383 63151004
Ocular hypertension 26.91 10.38 30 325605 1020 63162367
Throat tightness 26.88 10.38 219 325416 24668 63138719
Gastrooesophageal reflux disease 26.68 10.38 338 325297 95301 63068086
Pre-existing condition improved 26.61 10.38 5 325630 8239 63155148
Medication error 26.60 10.38 158 325477 52126 63111261
Pseudocellulitis 26.57 10.38 8 325627 13 63163374
Atelectasis 26.51 10.38 195 325440 21288 63142099
Herpes simplex 26.48 10.38 98 325537 8173 63155214
Bacterial sepsis 26.42 10.38 61 325574 3897 63159490
Sternal fracture 26.37 10.38 44 325591 2210 63161177
Obstructive airways disorder 26.16 10.38 41 325594 20658 63142729
Cholelithiasis 26.09 10.38 126 325509 43799 63119588
Red blood cell count decreased 26.05 10.38 321 325314 40324 63123063
Keratitis fungal 25.97 10.38 14 325621 153 63163234
Escherichia sepsis 25.88 10.38 70 325565 4937 63158450
Escherichia test positive 25.86 10.38 45 325590 2339 63161048
Pulmonary sepsis 25.86 10.38 36 325599 1540 63161847
Corneal opacity 25.84 10.38 25 325610 718 63162669
Depressed mood 25.83 10.38 112 325523 40079 63123308
Therapeutic response unexpected 25.83 10.38 35 325600 18724 63144663
Tardive dyskinesia 25.71 10.38 6 325629 8496 63154891
Hordeolum 25.67 10.38 54 325581 3238 63160149
Partial seizures 25.64 10.38 77 325558 5765 63157622
Tendonitis 25.61 10.38 38 325597 19577 63143810
Haematochezia 25.58 10.38 165 325470 53379 63110008
Alpha haemolytic streptococcal infection 25.51 10.38 32 325603 1235 63162152
Blood calcium abnormal 25.49 10.38 32 325603 1236 63162151
Pulmonary haemorrhage 25.48 10.38 88 325547 7093 63156294
Road traffic accident 25.47 10.38 99 325536 36533 63126854
Crossmatch incompatible 25.46 10.38 9 325626 30 63163357
Fear 25.37 10.38 26 325609 15740 63147647
Listeriosis 25.34 10.38 35 325600 1486 63161901
Staphylococcal bacteraemia 25.33 10.38 74 325561 5456 63157931
Adverse event 25.25 10.38 223 325412 67336 63096051
Hypertransaminasaemia 25.23 10.38 83 325552 6526 63156861
Drug tolerance 25.22 10.38 3 325632 6946 63156441
Urosepsis 25.10 10.38 172 325463 18352 63145035
Neoplasm recurrence 25.06 10.38 47 325588 2591 63160796
Type I hypersensitivity 24.99 10.38 50 325585 2892 63160495
Mantle cell lymphoma recurrent 24.94 10.38 15 325620 205 63163182
Hyperglycaemic hyperosmolar nonketotic syndrome 24.91 10.38 28 325607 961 63162426
Enteritis 24.73 10.38 96 325539 8190 63155197
Musculoskeletal chest pain 24.68 10.38 189 325446 20894 63142493
Product dispensing error 24.59 10.38 11 325624 10294 63153093
Cardiac failure 24.58 10.38 615 325020 88527 63074860
Hyperamylasaemia 24.36 10.38 20 325615 460 63162927
Lip swelling 24.22 10.38 80 325555 30983 63132404
Sensitivity to weather change 24.21 10.38 4 325631 7233 63156154
Alveolitis 24.12 10.38 49 325586 2866 63160521
Nervous system disorder 24.11 10.38 172 325463 18594 63144793
Pneumonia viral 23.82 10.38 92 325543 7830 63155557
Dermatitis atopic 23.81 10.38 10 325625 9714 63153673
Spinal fracture 23.79 10.38 168 325467 18103 63145284
Nasal abscess 23.68 10.38 14 325621 185 63163202
Movement disorder 23.67 10.38 47 325588 21614 63141773
Mesenteric abscess 23.66 10.38 11 325624 85 63163302
Hereditary angioedema 23.54 10.38 5 325630 7557 63155830
Disability 23.52 10.38 36 325599 18311 63145076
Allergy test negative 23.36 10.38 14 325621 190 63163197
Lymphoedema 23.22 10.38 120 325515 11572 63151815
Blood magnesium decreased 23.19 10.38 131 325504 13067 63150320
Hallucination, auditory 23.18 10.38 19 325616 12805 63150582
Intervertebral disc degeneration 23.06 10.38 28 325607 15704 63147683
Ear infection 23.05 10.38 109 325526 38104 63125283
Amenorrhoea 23.01 10.38 11 325624 9903 63153484
Autonomic neuropathy 22.91 10.38 29 325606 1130 63162257
Chemotherapy 22.88 10.38 34 325601 1545 63161842
Malignant neoplasm of unknown primary site 22.77 10.38 16 325619 289 63163098
Large intestinal ulcer perforation 22.71 10.38 10 325625 67 63163320
Breast cancer stage I 22.62 10.38 4 325631 6885 63156502
Hyperproteinaemia 22.53 10.38 11 325624 96 63163291
Product packaging confusion 22.51 10.38 13 325622 164 63163223
Hypomagnesaemia 22.50 10.38 236 325399 28501 63134886
Lung infiltration 22.48 10.38 139 325496 14324 63149063
Nightmare 22.43 10.38 40 325595 19154 63144233
Extrapyramidal disorder 22.42 10.38 21 325614 13263 63150124
Antithrombin III decreased 22.38 10.38 15 325620 250 63163137
Pneumomediastinum 22.37 10.38 32 325603 1404 63161983
Superficial spreading melanoma stage unspecified 22.35 10.38 12 325623 130 63163257
Cerebral aspergillosis 22.29 10.38 18 325617 404 63162983
Serotonin syndrome 22.27 10.38 74 325561 28608 63134779
Madarosis 22.26 10.38 49 325586 3032 63160355
Hypothyroidism 22.13 10.38 128 325507 42504 63120883
Enterococcal bacteraemia 21.98 10.38 32 325603 1427 63161960
Joint destruction 21.96 10.38 3 325632 6249 63157138
Bone marrow infiltration 21.90 10.38 22 325613 662 63162725
Stem cell transplant 21.90 10.38 36 325599 1786 63161601
Encephalitis 21.88 10.38 97 325538 8783 63154604
Meningitis pneumococcal 21.82 10.38 15 325620 261 63163126
Secondary immunodeficiency 21.81 10.38 31 325604 1352 63162035
Maternal exposure before pregnancy 21.77 10.38 6 325629 7597 63155790
Neck pain 21.63 10.38 239 325396 69079 63094308
Erysipelas 21.52 10.38 89 325546 7816 63155571
Pneumococcal sepsis 21.47 10.38 22 325613 678 63162709
Adverse drug reaction 21.40 10.38 548 325087 79166 63084221
Temperature regulation disorder 21.40 10.38 3 325632 6129 63157258
Eosinophil count increased 21.28 10.38 15 325620 10913 63152474
Oral disorder 21.28 10.38 96 325539 8758 63154629
Enterococcal sepsis 21.22 10.38 31 325604 1387 63162000
Bone infarction 21.17 10.38 16 325619 325 63163062
Choroiditis 21.16 10.38 13 325622 185 63163202
Vascular pain 21.13 10.38 23 325612 761 63162626
Leukaemia recurrent 21.12 10.38 30 325605 1308 63162079
Drug level increased 21.05 10.38 54 325581 22682 63140705
Cerebral venous thrombosis 21.02 10.38 38 325597 2036 63161351
Recall phenomenon 20.98 10.38 21 325614 629 63162758
Cytomegalovirus colitis 20.98 10.38 41 325594 2331 63161056
Infusion site swelling 20.96 10.38 12 325623 9758 63153629
Ileus paralytic 20.94 10.38 61 325574 4490 63158897
T-cell lymphoma refractory 20.86 10.38 9 325626 57 63163330
Gastrointestinal protozoal infection 20.86 10.38 7 325628 19 63163368
Gastrointestinal disorder 20.81 10.38 513 325122 130726 63032661
Atrial septal defect 20.77 10.38 5 325630 6933 63156454
Urinary tract infection 20.72 10.38 1601 324034 263083 62900304
Clostridium bacteraemia 20.69 10.38 13 325622 193 63163194
Anaphylactic reaction 20.66 10.38 464 325171 65636 63097751
Klebsiella sepsis 20.61 10.38 31 325604 1424 63161963
Swelling face 20.60 10.38 448 325187 63027 63100360
Phaeochromocytoma crisis 20.60 10.38 14 325621 239 63163148
Illness 20.58 10.38 157 325478 48902 63114485
Grip strength decreased 20.58 10.38 53 325582 22234 63141153
Platelet disorder 20.57 10.38 36 325599 1880 63161507
Therapeutic response decreased 20.47 10.38 209 325426 61316 63102071
Nail dystrophy 20.46 10.38 26 325609 1017 63162370
Rhinitis allergic 20.44 10.38 18 325617 11709 63151678
Multiple allergies 20.42 10.38 131 325504 13671 63149716
Product administration error 20.12 10.38 54 325581 22343 63141044
Birdshot chorioretinopathy 20.11 10.38 9 325626 63 63163324
Palmar erythema 20.02 10.38 34 325601 1733 63161654
Tonsillar disorder 19.92 10.38 27 325608 1126 63162261
Hysterectomy 19.91 10.38 12 325623 9487 63153900
Streptococcal bacteraemia 19.88 10.38 34 325601 1743 63161644
Gastroenteritis norovirus 19.84 10.38 37 325598 2031 63161356
Mucocutaneous ulceration 19.83 10.38 12 325623 166 63163221
Adenocarcinoma pancreas 19.78 10.38 26 325609 1052 63162335
Hyperkalaemia 19.78 10.38 180 325455 54023 63109364
Scar 19.71 10.38 25 325610 13757 63149630
Hypothalamic pituitary adrenal axis suppression 19.70 10.38 12 325623 168 63163219
Varicella zoster virus infection 19.69 10.38 43 325592 2646 63160741
Protein urine 19.69 10.38 22 325613 750 63162637
Venous thrombosis limb 19.68 10.38 46 325589 2962 63160425
Anticipatory anxiety 19.67 10.38 28 325607 1223 63162164
Intermenstrual bleeding 19.65 10.38 8 325627 7918 63155469
Hair texture abnormal 19.65 10.38 57 325578 4186 63159201
Subclavian vein thrombosis 19.63 10.38 35 325600 1855 63161532
Oesophageal squamous cell carcinoma 19.59 10.38 11 325624 131 63163256
Device leakage 19.58 10.38 6 325629 7090 63156297
Adenocarcinoma of colon 19.44 10.38 41 325594 2463 63160924
Babesiosis 19.43 10.38 13 325622 216 63163171
Precursor B-lymphoblastic lymphoma 19.23 10.38 7 325628 26 63163361
Angina pectoris 19.22 10.38 84 325551 29994 63133393
Coronary artery occlusion 19.15 10.38 9 325626 8182 63155205
Endocarditis 19.14 10.38 69 325566 5681 63157706
Eastern Cooperative Oncology Group performance status improved 19.14 10.38 6 325629 12 63163375
Dysphonia 19.13 10.38 347 325288 47267 63116120
Blood gases abnormal 19.12 10.38 22 325613 775 63162612
Enlarged uvula 19.10 10.38 12 325623 178 63163209
Spinal fusion surgery 19.08 10.38 3 325632 5625 63157762
Refractory anaemia with ringed sideroblasts 19.06 10.38 5 325630 3 63163384
Product substitution issue 18.99 10.38 33 325602 15963 63147424
Soft tissue infection 18.98 10.38 37 325598 2100 63161287
Arachnoiditis 18.95 10.38 15 325620 327 63163060
Polyp 18.95 10.38 5 325630 6516 63156871
Miosis 18.93 10.38 7 325628 7346 63156041
CSF oligoclonal band present 18.92 10.38 16 325619 384 63163003
Lactose intolerance 18.90 10.38 45 325590 2933 63160454
Exposure to toxic agent 18.89 10.38 3 325632 5584 63157803
Appendicitis 18.87 10.38 88 325547 8141 63155246
Cancer pain 18.82 10.38 47 325588 3158 63160229
Haemolytic anaemia 18.79 10.38 102 325533 10023 63153364
Tuberculoma of central nervous system 18.75 10.38 15 325620 332 63163055
Philadelphia chromosome positive 18.71 10.38 16 325619 390 63162997
Meningoencephalitis herpetic 18.67 10.38 27 325608 1197 63162190
Nodule 18.66 10.38 51 325584 20975 63142412
Abnormal dreams 18.50 10.38 16 325619 10500 63152887
Hyphaema 18.49 10.38 14 325621 285 63163102
Panic attack 18.47 10.38 56 325579 22275 63141112
Spinal stenosis 18.45 10.38 30 325605 14895 63148492
Pseudomyopia 18.37 10.38 8 325627 52 63163335
Product dose omission in error 18.36 10.38 8 325627 7604 63155783
Tachycardia 18.35 10.38 761 324874 117395 63045992
Ankle brachial index decreased 18.29 10.38 9 325626 80 63163307
Pulse waveform abnormal 18.29 10.38 9 325626 80 63163307
Encephalopathy 18.26 10.38 289 325346 38331 63125056
Tracheal deviation 18.25 10.38 11 325624 151 63163236
C-reactive protein increased 18.22 10.38 359 325276 94348 63069039
Intraocular pressure decreased 18.19 10.38 10 325625 114 63163273
Nail infection 18.08 10.38 40 325595 2483 63160904
Atypical pneumonia 18.07 10.38 57 325578 4383 63159004
Vitamin D deficiency 18.06 10.38 27 325608 13865 63149522
Hypertension 18.00 10.38 1212 324423 278091 62885296
Escherichia urinary tract infection 17.99 10.38 114 325521 11848 63151539
Mood swings 17.94 10.38 42 325593 18206 63145181
Respiratory depth decreased 17.91 10.38 7 325628 33 63163354
Carotid intima-media thickness increased 17.91 10.38 9 325626 84 63163303
Hallucination 17.91 10.38 187 325448 54630 63108757
Blood pressure diastolic increased 17.89 10.38 15 325620 9995 63153392
Catabolic state 17.88 10.38 8 325627 56 63163331
Compression fracture 17.87 10.38 73 325562 6375 63157012
Hypotension 17.86 10.38 1627 324008 270977 62892410
Seasonal allergy 17.81 10.38 175 325460 20775 63142612
Spinal osteoarthritis 17.79 10.38 35 325600 16151 63147236
Diverticular perforation 17.79 10.38 49 325586 3493 63159894
Virilism 17.75 10.38 7 325628 34 63163353
Herpes simplex reactivation 17.69 10.38 18 325617 550 63162837
Myopathy 17.67 10.38 108 325527 11083 63152304
Oral pain 17.66 10.38 223 325412 28171 63135216
Heart rate decreased 17.64 10.38 149 325486 45411 63117976
Meningitis cryptococcal 17.63 10.38 28 325607 1349 63162038
Lymphoma 17.62 10.38 115 325520 12072 63151315
Endocarditis bacterial 17.59 10.38 19 325616 623 63162764
Circulatory collapse 17.57 10.38 181 325454 21757 63141630
Cerebellar haemangioma 17.56 10.38 9 325626 88 63163299
Device use error 17.55 10.38 4 325631 5757 63157630
Dermatitis acneiform 17.53 10.38 61 325574 4935 63158452
Eosinophilic cystitis 17.52 10.38 8 325627 59 63163328
Gene mutation 17.51 10.38 31 325604 1634 63161753
Menstruation irregular 17.48 10.38 7 325628 6997 63156390
Second primary malignancy 17.47 10.38 84 325551 7869 63155518
Procalcitonin abnormal 17.44 10.38 6 325629 18 63163369
Meningitis 17.39 10.38 78 325557 7099 63156288
Refractory anaemia with an excess of blasts 17.38 10.38 16 325619 431 63162956
Soft tissue disorder 17.30 10.38 56 325579 4366 63159021
Cardiac murmur 17.30 10.38 30 325605 14522 63148865
Akathisia 17.23 10.38 13 325622 9133 63154254
Insurance issue 17.21 10.38 5 325630 6116 63157271
Metastatic malignant melanoma 17.20 10.38 27 325608 1288 63162099
Myelopathy 17.18 10.38 42 325593 2784 63160603
Hypophagia 17.16 10.38 240 325395 31019 63132368
Listeria sepsis 17.14 10.38 20 325615 715 63162672
Fungaemia 17.11 10.38 38 325597 2365 63161022
Vitreous loss 17.11 10.38 4 325631 0 63163387
Klebsiella infection 17.07 10.38 88 325547 8478 63154909
Hyperpyrexia 17.02 10.38 49 325586 3583 63159804
Hypogeusia 16.95 10.38 27 325608 1304 63162083
Chronic myelomonocytic leukaemia 16.94 10.38 14 325621 325 63163062
Lymphocyte count decreased 16.89 10.38 233 325402 30024 63133363
Device adhesion issue 16.85 10.38 3 325632 5138 63158249
Cholecystitis chronic 16.77 10.38 17 325618 10344 63153043
Device failure 16.74 10.38 5 325630 6006 63157381
Sinus polyp 16.73 10.38 15 325620 390 63162997
Spinal compression fracture 16.69 10.38 128 325507 14155 63149232
Thiopurine methyltransferase decreased 16.66 10.38 14 325621 333 63163054
Anhedonia 16.65 10.38 19 325616 10955 63152432
Tooth erosion 16.61 10.38 16 325619 457 63162930
Hypoglobulinaemia 16.54 10.38 7 325628 42 63163345
Necrotising retinitis 16.51 10.38 15 325620 397 63162990
Creatinine renal clearance decreased 16.47 10.38 37 325598 16271 63147116
Vein discolouration 16.47 10.38 12 325623 230 63163157
Neurological symptom 16.45 10.38 66 325569 5717 63157670
Incorrect product administration duration 16.45 10.38 21 325614 11525 63151862
Skin candida 16.36 10.38 30 325605 1625 63161762
Bone debridement 16.34 10.38 12 325623 233 63163154
Enterocolitis infectious 16.33 10.38 30 325605 1628 63161759
Phrenic nerve paralysis 16.32 10.38 11 325624 185 63163202
Fungal abscess central nervous system 16.29 10.38 5 325630 9 63163378
Necrotising fasciitis 16.21 10.38 43 325592 2998 63160389
Acne 16.16 10.38 63 325572 23230 63140157
N-terminal prohormone brain natriuretic peptide decreased 16.13 10.38 6 325629 24 63163363
Intracranial mass 16.09 10.38 25 325610 1182 63162205
Eye abscess 16.06 10.38 10 325625 146 63163241
Foetal growth restriction 16.04 10.38 79 325556 7474 63155913
Confusional state 16.03 10.38 1021 324614 235359 62928028
Visceral leishmaniasis 16.03 10.38 17 325618 546 63162841
Polyarthritis 16.02 10.38 17 325618 10129 63153258
Aggression 16.02 10.38 64 325571 23434 63139953
Cholangitis infective 16.01 10.38 14 325621 352 63163035
Bronchiectasis 16.00 10.38 37 325598 16105 63147282
Blood alkaline phosphatase abnormal 15.98 10.38 17 325618 548 63162839
Botryomycosis 15.94 10.38 6 325629 25 63163362
Steroid diabetes 15.93 10.38 26 325609 1282 63162105
Pneumothorax 15.92 10.38 140 325495 16121 63147266
Capillary leak syndrome 15.90 10.38 35 325600 2165 63161222
Iridocyclitis 15.89 10.38 38 325597 2484 63160903
Frustration tolerance decreased 15.85 10.38 8 325627 6980 63156407
Intentional dose omission 15.83 10.38 11 325624 8064 63155323
Alanine aminotransferase increased 15.81 10.38 667 324968 103103 63060284
Palatal ulcer 15.80 10.38 8 325627 76 63163311
Haematoma 15.78 10.38 109 325526 34711 63128676
Salmonella bacteraemia 15.77 10.38 10 325625 151 63163236
Genital haemorrhage 15.74 10.38 9 325626 7323 63156064
Rectal adenocarcinoma 15.73 10.38 18 325617 630 63162757
Platelet transfusion 15.66 10.38 20 325615 786 63162601
Respiratory depression 15.65 10.38 29 325606 13686 63149701
Alopecia totalis 15.65 10.38 14 325621 363 63163024
Intracranial tumour haemorrhage 15.54 10.38 11 325624 201 63163186
Skin necrosis 15.48 10.38 30 325605 13920 63149467
Application site erythema 15.46 10.38 3 325632 4832 63158555
Hypophosphataemia 15.43 10.38 106 325529 11320 63152067
Non-small cell lung cancer 15.42 10.38 47 325588 3548 63159839
Haematemesis 15.42 10.38 92 325543 30320 63133067
Hypersensitivity myocarditis 15.36 10.38 11 325624 205 63163182
Target skin lesion 15.35 10.38 9 325626 117 63163270
Chills 15.35 10.38 720 324915 112658 63050729
Clostridial sepsis 15.31 10.38 16 325619 505 63162882
Vitritis 15.30 10.38 22 325613 970 63162417
Chemical burns of eye 15.28 10.38 8 325627 82 63163305
Drug level decreased 15.25 10.38 11 325624 7908 63155479
Enterococcal infection 15.20 10.38 80 325555 7768 63155619
Disturbance in attention 15.19 10.38 124 325511 38065 63125322
Iris adhesions 15.16 10.38 13 325622 318 63163069
Myeloma cast nephropathy 15.09 10.38 9 325626 121 63163266
Meningitis bacterial 15.09 10.38 26 325609 1341 63162046
Uterine leiomyoma 14.99 10.38 15 325620 9183 63154204
Pulmonary trichosporonosis 14.96 10.38 7 325628 55 63163332
Transplant rejection 14.96 10.38 20 325615 10760 63152627
Product adhesion issue 14.94 10.38 3 325632 4716 63158671
Sense of oppression 14.90 10.38 22 325613 994 63162393
Meniscus injury 14.89 10.38 9 325626 7105 63156282
Lineage switch leukaemia 14.89 10.38 4 325631 3 63163384
Haemophilus bacteraemia 14.89 10.38 4 325631 3 63163384
Hernia 14.88 10.38 26 325609 12548 63150839
Low density lipoprotein increased 14.84 10.38 7 325628 6350 63157037
Drug clearance decreased 14.80 10.38 27 325608 1457 63161930
Arterial occlusive disease 14.79 10.38 6 325629 5952 63157435
Chronic kidney disease 14.78 10.38 155 325480 45243 63118144
Acute monocytic leukaemia 14.78 10.38 9 325626 126 63163261
Apathy 14.73 10.38 14 325621 8780 63154607
Electrocardiogram QRS complex prolonged 14.71 10.38 6 325629 5932 63157455
Hydrocephalus 14.69 10.38 60 325575 5240 63158147
Breast cancer stage III 14.68 10.38 19 325616 10367 63153020
Device related infection 14.67 10.38 184 325451 23208 63140179
Lymphorrhoea 14.64 10.38 7 325628 58 63163329
Corneal perforation 14.64 10.38 16 325619 532 63162855
Pulmonary hypertension 14.56 10.38 121 325514 37002 63126385
Hypergeusia 14.54 10.38 5 325630 15 63163372
Pustular psoriasis 14.52 10.38 3 325632 4623 63158764
Catheterisation cardiac 14.42 10.38 3 325632 4600 63158787
Skin ulcer 14.41 10.38 146 325489 42899 63120488
Failure to thrive 14.38 10.38 74 325561 7124 63156263
Dysentery 14.37 10.38 21 325614 940 63162447
Cataract traumatic 14.36 10.38 4 325631 4 63163383
Major depression 14.35 10.38 12 325623 8006 63155381
Neoplasm 14.32 10.38 75 325560 7270 63156117
Non-small cell lung cancer metastatic 14.31 10.38 17 325618 620 63162767
Cutaneous mucormycosis 14.30 10.38 5 325630 16 63163371
Adjusted calcium increased 14.30 10.38 5 325630 16 63163371
Bacterial infection 14.27 10.38 158 325477 19341 63144046
Eye irritation 14.25 10.38 61 325574 21910 63141477
Pseudomonal bacteraemia 14.23 10.38 28 325607 1600 63161787
Abortion induced 14.21 10.38 19 325616 10223 63153164
Metapneumovirus infection 14.19 10.38 22 325613 1038 63162349
Rotator cuff syndrome 14.16 10.38 30 325605 13472 63149915
Bipolar disorder 14.14 10.38 12 325623 7948 63155439
Asphyxia 14.13 10.38 7 325628 6174 63157213
Injection site irritation 14.12 10.38 4 325631 4974 63158413
Unmasking of previously unidentified disease 14.12 10.38 21 325614 955 63162432
Dyskinesia 14.10 10.38 101 325534 31901 63131486
Cerebral toxoplasmosis 14.09 10.38 21 325614 957 63162430
Body temperature decreased 14.07 10.38 55 325580 20264 63143123
Superior vena cava occlusion 14.06 10.38 7 325628 64 63163323
Tachypnoea 13.97 10.38 143 325492 17159 63146228
Hepatic infection fungal 13.91 10.38 6 325629 38 63163349
Unintentional medical device removal 13.87 10.38 7 325628 6108 63157279
Crohn's disease 13.84 10.38 4 325631 4909 63158478
Retinal detachment 13.81 10.38 64 325571 5905 63157482
Chest discomfort 13.76 10.38 693 324942 109276 63054111
Complication associated with device 13.74 10.38 43 325592 16935 63146452
Injection site discolouration 13.73 10.38 12 325623 7836 63155551
Excessive eye blinking 13.68 10.38 24 325611 1256 63162131
Aspergilloma 13.62 10.38 11 325624 247 63163140
Cerebral artery thrombosis 13.62 10.38 13 325622 367 63163020
Oncologic complication 13.58 10.38 10 325625 195 63163192
Hypothermia 13.56 10.38 31 325604 13550 63149837
Renal amyloidosis 13.53 10.38 9 325626 148 63163239
Hair colour changes 13.52 10.38 41 325594 3086 63160301
Product administration interrupted 13.51 10.38 4 325631 4832 63158555
Infection reactivation 13.49 10.38 23 325612 1176 63162211
Diarrhoea haemorrhagic 13.49 10.38 86 325549 8956 63154431
Plasma cell myeloma in remission 13.48 10.38 4 325631 6 63163381
Dysaesthesia pharynx 13.48 10.38 9 325626 149 63163238
Infusion site pain 13.46 10.38 43 325592 16826 63146561
Pleocytosis 13.42 10.38 19 325616 826 63162561
Muscle rigidity 13.40 10.38 24 325611 11476 63151911
Osteomyelitis bacterial 13.40 10.38 10 325625 199 63163188
Diffuse large B-cell lymphoma 13.40 10.38 69 325566 6643 63156744
Pleuroparenchymal fibroelastosis 13.39 10.38 8 325627 108 63163279
Polychromasia 13.38 10.38 9 325626 151 63163236
Sexual dysfunction 13.33 10.38 3 325632 4356 63159031
Embolism venous 13.31 10.38 41 325594 3113 63160274
Hemiparesis 13.29 10.38 180 325455 23102 63140285
Product dose omission issue 13.27 10.38 1028 324607 233285 62930102
Paraparesis 13.23 10.38 33 325602 2215 63161172
Adenoviral haemorrhagic cystitis 13.22 10.38 9 325626 154 63163233
Infusion related hypersensitivity reaction 13.22 10.38 11 325624 258 63163129
Blood albumin abnormal 13.13 10.38 15 325620 524 63162863
Cardiomyopathy 13.11 10.38 143 325492 17441 63145946
Substance-induced mood disorder 13.10 10.38 4 325631 7 63163380
Lipogranuloma 13.10 10.38 4 325631 7 63163380
Postictal state 13.07 10.38 21 325614 1022 63162365
Bradyphrenia 13.05 10.38 10 325625 6970 63156417
Musculoskeletal disorder 12.98 10.38 58 325577 20586 63142801
Pulmonary oedema 12.95 10.38 371 325264 54502 63108885
Blood creatine phosphokinase increased 12.95 10.38 97 325538 30333 63133054
Tumour pain 12.91 10.38 25 325610 1412 63161975
Ureteritis 12.89 10.38 5 325630 23 63163364
Superior sagittal sinus thrombosis 12.88 10.38 18 325617 773 63162614
Cavernous sinus syndrome 12.83 10.38 3 325632 0 63163387
Cleft palate repair 12.83 10.38 3 325632 0 63163387
Bronchitis pneumococcal 12.83 10.38 3 325632 0 63163387
Radiotherapy to brain 12.83 10.38 3 325632 0 63163387
Oropharyngeal squamous cell carcinoma 12.83 10.38 3 325632 0 63163387
Emphysematous cystitis 12.83 10.38 9 325626 162 63163225
Demyelination 12.83 10.38 10 325625 6910 63156477
Transplant 12.75 10.38 18 325617 780 63162607
Peritonitis viral 12.73 10.38 6 325629 48 63163339
Bone marrow disorder 12.73 10.38 34 325601 2380 63161007
Balamuthia infection 12.72 10.38 5 325630 24 63163363
Pneumonia parainfluenzae viral 12.72 10.38 7 325628 80 63163307
Pharyngitis streptococcal 12.69 10.38 22 325613 10650 63152737
Anaphylactoid reaction 12.67 10.38 45 325590 3678 63159709
Glioblastoma multiforme 12.67 10.38 18 325617 785 63162602
Rales 12.66 10.38 29 325606 12668 63150719
Arteriosclerosis 12.66 10.38 20 325615 10046 63153341
Cyst 12.66 10.38 34 325601 14065 63149322
Septic pulmonary embolism 12.64 10.38 7 325628 81 63163306
Pre-eclampsia 12.61 10.38 17 325618 9116 63154271
Blood immunoglobulin G increased 12.61 10.38 34 325601 2393 63160994
Spinal cord injury 12.61 10.38 19 325616 874 63162513
Bronchitis viral 12.58 10.38 21 325614 1055 63162332
Genital rash 12.58 10.38 15 325620 549 63162838
Ankle fracture 12.57 10.38 48 325587 17807 63145580
Thrombophlebitis 12.55 10.38 50 325585 4318 63159069
Infection in an immunocompromised host 12.50 10.38 17 325618 711 63162676
Blood glucose decreased 12.50 10.38 60 325575 20892 63142495
Leukaemic lymphoma 12.49 10.38 7 325628 83 63163304
Granuloma 12.47 10.38 7 325628 5754 63157633
Gastric perforation 12.47 10.38 27 325608 1652 63161735
Burning sensation 12.45 10.38 200 325435 54207 63109180
Pneumopericardium 12.42 10.38 6 325629 51 63163336
Lymphangitis 12.39 10.38 19 325616 888 63162499
Atypical haemolytic uraemic syndrome 12.38 10.38 17 325618 718 63162669
Sarcoidosis 12.33 10.38 11 325624 7111 63156276
Toxic neuropathy 12.32 10.38 13 325622 415 63162972
SARS-CoV-2 test positive 12.25 10.38 77 325558 7979 63155408
Phyllodes tumour 12.25 10.38 5 325630 27 63163360
Angina unstable 12.23 10.38 11 325624 7084 63156303
Fungal oesophagitis 12.22 10.38 17 325618 727 63162660
Maternal exposure timing unspecified 12.20 10.38 11 325624 7076 63156311
Subileus 12.20 10.38 40 325595 3139 63160248
Quadriparesis 12.17 10.38 30 325605 1999 63161388
Therapeutic response delayed 12.16 10.38 16 325619 648 63162739
Ligament sprain 12.16 10.38 30 325605 12770 63150617
Urinary tract infection enterococcal 12.14 10.38 36 325599 2677 63160710
Sputum discoloured 12.13 10.38 43 325592 16304 63147083
Crepitations 12.11 10.38 14 325621 8026 63155361
Respiratory arrest 12.09 10.38 108 325527 32537 63130850
Morganella infection 12.03 10.38 16 325619 655 63162732
Diastolic hypotension 12.01 10.38 7 325628 90 63163297
Human herpesvirus 7 infection 12.00 10.38 8 325627 132 63163255
Peritonitis bacterial 11.97 10.38 5 325630 4874 63158513
Post procedural complication 11.96 10.38 46 325589 17028 63146359
Sinus congestion 11.95 10.38 50 325585 18073 63145314
Herpes zoster reactivation 11.94 10.38 7 325628 91 63163296
Drug level below therapeutic 11.92 10.38 5 325630 4861 63158526
Limb injury 11.92 10.38 79 325556 25398 63137989
Corneal infiltrates 11.90 10.38 8 325627 134 63163253
Limb operation 11.89 10.38 3 325632 4028 63159359
Light chain analysis 11.88 10.38 4 325631 11 63163376
Uterine fistula 11.88 10.38 4 325631 11 63163376
Dysaesthesia 11.87 10.38 50 325585 4428 63158959
Oxygen saturation 11.86 10.38 9 325626 184 63163203
Femur fracture 11.85 10.38 147 325488 41609 63121778
Epstein Barr virus positive mucocutaneous ulcer 11.85 10.38 13 325622 434 63162953
Laryngeal inflammation 11.85 10.38 8 325627 135 63163252
Progressive multifocal leukoencephalopathy 11.85 10.38 110 325525 12861 63150526
Bacillus infection 11.84 10.38 18 325617 835 63162552
Infusion site streaking 11.77 10.38 14 325621 511 63162876
Visual acuity reduced 11.75 10.38 167 325468 21659 63141728
Monoclonal immunoglobulin increased 11.70 10.38 8 325627 138 63163249
White blood cell disorder 11.69 10.38 34 325601 2500 63160887
Application site pruritus 11.68 10.38 3 325632 3981 63159406
Haemodynamic instability 11.67 10.38 84 325551 9106 63154281
Myopathy toxic 11.67 10.38 14 325621 516 63162871
Electrocardiogram QT prolonged 11.65 10.38 225 325410 59305 63104082
Inflammatory bowel disease 11.63 10.38 3 325632 3970 63159417
Subcutaneous emphysema 11.63 10.38 18 325617 848 63162539
Actinomycosis 11.63 10.38 20 325615 1030 63162357
Somnambulism 11.62 10.38 7 325628 5536 63157851
Therapy cessation 11.61 10.38 100 325535 30357 63133030
Cardiac dysfunction 11.60 10.38 32 325603 2283 63161104
Acute sinusitis 11.57 10.38 45 325590 3842 63159545
Seronegative arthritis 11.57 10.38 3 325632 3956 63159431
Human herpesvirus 8 infection 11.55 10.38 10 325625 248 63163139
Lentigo maligna 11.55 10.38 10 325625 248 63163139
Guillain-Barre syndrome 11.53 10.38 45 325590 3848 63159539
Pulmonary alveolar haemorrhage 11.51 10.38 51 325584 4617 63158770
Affect lability 11.51 10.38 25 325610 11126 63152261
Mucosal infection 11.49 10.38 9 325626 193 63163194
Emotional distress 11.48 10.38 109 325526 32440 63130947
Aortic arteriosclerosis 11.47 10.38 9 325626 6200 63157187
Large intestine polyp 11.45 10.38 15 325620 8142 63155245
Renal disorder 11.44 10.38 235 325400 32739 63130648
Immune system disorder 11.42 10.38 88 325547 9746 63153641
Atrial rupture 11.42 10.38 6 325629 62 63163325
Feeling jittery 11.42 10.38 112 325523 13291 63150096
Sialoadenitis 11.41 10.38 26 325609 1646 63161741
Electrophoresis protein abnormal 11.39 10.38 4 325631 13 63163374
Expired product administered 11.37 10.38 9 325626 6172 63157215
Colony stimulating factor therapy 11.37 10.38 11 325624 316 63163071
Optic neuritis 11.35 10.38 16 325619 8419 63154968
Listeria encephalitis 11.35 10.38 10 325625 254 63163133
Post procedural infection 11.34 10.38 19 325616 9323 63154064
Wrist fracture 11.29 10.38 34 325601 13553 63149834
Skin sensitisation 11.28 10.38 18 325617 871 63162516
Protein total abnormal 11.27 10.38 13 325622 459 63162928
Infusion site haemorrhage 11.27 10.38 6 325629 5080 63158307
Proctitis 11.23 10.38 7 325628 5434 63157953
Blood iron abnormal 11.21 10.38 3 325632 3873 63159514
Gastrointestinal motility disorder 11.20 10.38 54 325581 5065 63158322
Choking 11.17 10.38 21 325614 9858 63153529
Meningitis streptococcal 11.17 10.38 8 325627 149 63163238
Urethral cancer 11.17 10.38 4 325631 14 63163373
Blood stem cell transplant failure 11.13 10.38 8 325627 150 63163237
Transverse sinus thrombosis 11.09 10.38 14 325621 544 63162843
Diverticulitis intestinal perforated 11.08 10.38 7 325628 105 63163282
Hepatic failure 11.05 10.38 250 325385 35406 63127981
Loss of consciousness 11.04 10.38 494 325141 117627 63045760
Acute febrile neutrophilic dermatosis 11.04 10.38 37 325598 2937 63160450
Vertebral lesion 11.04 10.38 15 325620 627 63162760
Histiocytic sarcoma 11.02 10.38 6 325629 67 63163320
Salmonellosis 11.00 10.38 21 325614 1173 63162214
Reflux gastritis 10.99 10.38 21 325614 1174 63162213
Systemic mycosis 10.97 10.38 21 325614 1176 63162211
Nasal disorder 10.96 10.38 36 325599 2828 63160559
Rash maculo-papular 10.96 10.38 227 325408 31669 63131718
Bundle branch block left 10.96 10.38 12 325623 7047 63156340
Blood corticotrophin increased 10.94 10.38 6 325629 68 63163319
Energy increased 10.94 10.38 35 325600 2712 63160675
Differentiation syndrome 10.91 10.38 20 325615 1083 63162304
Foetal exposure during delivery 10.86 10.38 8 325627 156 63163231
Hypoaesthesia 10.86 10.38 1004 324631 167389 62995998
Malignant transformation 10.84 10.38 12 325623 405 63162982
Oropharyngeal candidiasis 10.81 10.38 20 325615 1091 63162296
Forced expiratory volume decreased 10.80 10.38 6 325629 4962 63158425
Neuralgia 10.78 10.38 190 325445 25736 63137651
Splenic infection fungal 10.77 10.38 3 325632 3 63163384
Capnocytophaga infection 10.77 10.38 3 325632 3 63163384
Serology abnormal 10.77 10.38 3 325632 3 63163384
Kernicterus 10.77 10.38 3 325632 3 63163384
Gingival swelling 10.69 10.38 48 325587 4370 63159017
Bacterial endophthalmitis 10.63 10.38 7 325628 113 63163274
Secretion discharge 10.60 10.38 30 325605 12201 63151186
Atrioventricular block first degree 10.60 10.38 13 325622 7260 63156127
Eye infection 10.60 10.38 102 325533 12043 63151344
Retinal ischaemia 10.58 10.38 11 325624 345 63163042
Stenotrophomonas test positive 10.57 10.38 4 325631 17 63163370
Gastrointestinal toxicity 10.56 10.38 72 325563 7669 63155718
Pulse absent 10.56 10.38 55 325580 5319 63158068
Drug-induced liver injury 10.54 10.38 144 325491 40078 63123309
Hallucination, visual 10.53 10.38 57 325578 19241 63144146
Soft tissue injury 10.52 10.38 25 325610 1627 63161760
Graft versus host disease 10.51 10.38 65 325570 6698 63156689
Mesenteric haemorrhage 10.50 10.38 5 325630 41 63163346
Blood calcium increased 10.49 10.38 83 325552 9267 63154120
Trichosporon infection 10.49 10.38 10 325625 282 63163105
Humerus fracture 10.47 10.38 80 325555 8836 63154551
Urinary tract infection bacterial 10.47 10.38 53 325582 5069 63158318
Chest wall mass 10.44 10.38 6 325629 75 63163312
Libido increased 10.41 10.38 22 325613 1323 63162064
Leukocytosis 10.41 10.38 189 325446 25746 63137641
Immunodeficiency 10.41 10.38 61 325574 20193 63143194
Depressive symptom 10.40 10.38 4 325631 4098 63159289

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 2377.25 11.57 2337 300629 39700 34614265
Neuropathy peripheral 1403.75 11.57 2556 300410 80707 34573258
Neutropenia 1154.29 11.57 3475 299491 153303 34500662
Thrombocytopenia 988.25 11.57 3287 299679 152960 34501005
Febrile neutropenia 940.22 11.57 2962 300004 133887 34520078
Pneumonia 928.48 11.57 5832 297134 356795 34297170
Completed suicide 718.24 11.57 31 302935 98137 34555828
Drug abuse 653.76 11.57 55 302911 99041 34554924
Plasma cell myeloma recurrent 641.99 11.57 429 302537 4036 34649929
Off label use 575.29 11.57 5848 297118 413676 34240289
Disease progression 565.52 11.57 2138 300828 105939 34548026
Drug interaction 520.39 11.57 720 302246 225226 34428739
Platelet count decreased 471.57 11.57 2171 300795 117546 34536419
Deep vein thrombosis 455.04 11.57 1421 301545 63827 34590138
Unevaluable event 450.70 11.57 921 302045 31669 34622296
Pancytopenia 428.07 11.57 1796 301170 93361 34560604
Intentional overdose 356.55 11.57 4 302962 43670 34610295
Overdose 345.24 11.57 179 302787 90880 34563085
Plasmacytoma 331.61 11.57 267 302699 3424 34650541
Full blood count decreased 321.56 11.57 569 302397 17519 34636446
Cytopenia 313.23 11.57 464 302502 12259 34641706
White blood cell count decreased 310.03 11.57 1639 301327 93806 34560159
Thrombosis 309.39 11.57 1052 301914 49406 34604559
Fatigue 296.99 11.57 4680 298286 365973 34287992
Pulmonary embolism 287.94 11.57 1536 301430 88210 34565755
Sepsis 274.41 11.57 2418 300548 164143 34489822
Septic shock 256.52 11.57 1267 301699 70567 34583398
Rheumatoid arthritis 255.41 11.57 20 302946 38218 34615747
Arthralgia 252.84 11.57 701 302265 169340 34484625
Rhabdomyolysis 252.42 11.57 138 302828 68025 34585940
Constipation 252.22 11.57 2039 300927 134943 34519022
Neutropenic sepsis 244.60 11.57 433 302533 13334 34640631
Polyneuropathy 238.67 11.57 448 302518 14448 34639517
Tumour lysis syndrome 235.64 11.57 482 302484 16577 34637388
Therapy partial responder 218.69 11.57 338 302628 9278 34644687
Suicide attempt 218.00 11.57 38 302928 39078 34614887
Suicidal ideation 214.94 11.57 44 302922 40344 34613621
Laboratory test abnormal 209.54 11.57 512 302454 19879 34634086
Inappropriate schedule of product administration 201.92 11.57 147 302819 62149 34591816
Death 198.09 11.57 4675 298291 393374 34260591
Neutrophil count decreased 196.55 11.57 921 302045 50183 34603782
Injection site pain 194.55 11.57 49 302917 38956 34615009
Psoriasis 183.73 11.57 54 302912 38758 34615207
Intentional product misuse 179.82 11.57 85 302881 45526 34608439
Blood creatine phosphokinase increased 179.31 11.57 82 302884 44775 34609190
Plasma cell leukaemia 178.87 11.57 108 302858 836 34653129
Depression 176.23 11.57 360 302606 96738 34557227
Endophthalmitis 174.12 11.57 182 302784 3326 34650639
Myelodysplastic syndrome 169.10 11.57 455 302511 18753 34635212
Hiccups 168.75 11.57 309 302657 9773 34644192
Mucormycosis 164.26 11.57 229 302737 5713 34648252
Pyrexia 160.45 11.57 3895 299071 329118 34324847
Intraocular pressure increased 157.15 11.57 213 302753 5170 34648795
Pneumocystis jirovecii pneumonia 156.83 11.57 450 302516 19260 34634705
Leukopenia 155.57 11.57 1005 301961 61851 34592114
COVID-19 pneumonia 155.52 11.57 408 302558 16559 34637406
Wrong technique in product usage process 154.75 11.57 59 302907 35927 34618038
Hospitalisation 154.37 11.57 159 302807 56743 34597222
Mucosal inflammation 154.35 11.57 704 302262 37918 34616047
Light chain analysis increased 151.23 11.57 113 302853 1288 34652677
Anxiety 145.30 11.57 413 302553 99015 34554950
Stress 144.04 11.57 42 302924 30305 34623660
Complication of device insertion 143.26 11.57 48 302918 57 34653908
Drug dependence 142.93 11.57 20 302946 24197 34629768
Drug hypersensitivity 142.37 11.57 303 302663 80226 34573739
Coronary artery disease 137.93 11.57 129 302837 48176 34605789
Bronchopulmonary aspergillosis 135.89 11.57 354 302612 14305 34639660
Osteonecrosis 135.40 11.57 357 302609 14533 34639432
Rhinocerebral mucormycosis 134.20 11.57 75 302891 493 34653472
Febrile bone marrow aplasia 134.13 11.57 249 302717 7960 34646005
Headache 132.18 11.57 1108 301858 199527 34454438
Venoocclusive liver disease 129.37 11.57 241 302725 7725 34646240
Hypoglycaemia 127.51 11.57 172 302794 54468 34599497
Anaemia 125.67 11.57 2773 300193 230562 34423403
Diarrhoea 124.21 11.57 4330 298636 385582 34268383
Incorrect dose administered 123.15 11.57 102 302864 40413 34613552
Malignant neoplasm progression 120.65 11.57 1230 301736 86816 34567149
Squamous cell carcinoma of skin 120.17 11.57 281 302685 10600 34643365
Osteonecrosis of jaw 118.49 11.57 383 302583 17506 34636459
Serotonin syndrome 116.38 11.57 17 302949 19916 34634049
Loss of personal independence in daily activities 115.93 11.57 72 302894 33107 34620858
Strongyloidiasis 115.91 11.57 130 302836 2581 34651384
Plasma cell myeloma refractory 115.60 11.57 70 302896 545 34653420
Condition aggravated 114.88 11.57 1088 301878 191108 34462857
Cytokine release syndrome 113.94 11.57 446 302520 22431 34631534
Hallucination 113.33 11.57 169 302797 51329 34602636
Peripheral sensory neuropathy 112.90 11.57 207 302759 6553 34647412
Aggression 112.48 11.57 103 302863 38861 34615104
Cytomegalovirus chorioretinitis 112.43 11.57 147 302819 3442 34650523
Asthma 111.43 11.57 123 302843 42533 34611432
Myocardial infarction 110.99 11.57 606 302360 120479 34533486
Adverse drug reaction 110.71 11.57 526 302440 28816 34625149
Neuroleptic malignant syndrome 110.21 11.57 13 302953 17921 34636044
Haematotoxicity 109.01 11.57 228 302738 7966 34645999
Musculoskeletal stiffness 108.86 11.57 147 302819 46533 34607432
Myalgia 107.60 11.57 371 302595 83739 34570226
Blood pressure increased 105.82 11.57 399 302567 87703 34566262
Sedation 105.49 11.57 26 302940 20980 34632985
Psoriatic arthropathy 104.43 11.57 22 302944 19776 34634189
Bone marrow failure 104.33 11.57 516 302450 28737 34625228
Bacteraemia 103.60 11.57 391 302575 19326 34634639
Infection 102.93 11.57 1223 301743 89692 34564273
Rash 100.58 11.57 2584 300382 220168 34433797
Blood pressure fluctuation 99.59 11.57 47 302919 25202 34628763
Drug withdrawal syndrome 98.73 11.57 25 302941 19809 34634156
Coma 94.70 11.57 156 302810 45522 34608443
Angioedema 94.11 11.57 111 302855 37263 34616702
Hyperglycaemia 93.83 11.57 625 302341 38855 34615110
Somnolence 91.74 11.57 575 302391 110541 34543424
Product prescribing error 91.47 11.57 42 302924 22885 34631080
Electrocardiogram QT prolonged 91.46 11.57 133 302833 40819 34613146
Myelosuppression 90.65 11.57 369 302597 18896 34635069
Multiple sclerosis relapse 90.18 11.57 6 302960 13127 34640838
Lactic acidosis 90.02 11.57 101 302865 34671 34619294
COVID-19 89.44 11.57 1047 301919 76503 34577462
Diffuse large B-cell lymphoma recurrent 88.62 11.57 124 302842 3104 34650861
Hypofibrinogenaemia 88.24 11.57 90 302876 1596 34652369
Pain 88.22 11.57 1246 301720 203429 34450536
Corneal oedema 87.38 11.57 81 302885 1270 34652695
Therapy non-responder 87.25 11.57 610 302356 38536 34615429
Synovitis 86.92 11.57 10 302956 14056 34639909
Monoclonal immunoglobulin present 85.40 11.57 71 302895 955 34653010
Tooth disorder 84.20 11.57 246 302720 10636 34643329
International normalised ratio increased 82.84 11.57 179 302787 47148 34606817
Intentional self-injury 82.14 11.57 11 302955 13760 34640205
Haemophagocytic lymphohistiocytosis 81.66 11.57 273 302693 12700 34641265
Bone lesion 81.61 11.57 114 302852 2849 34651116
Hypercalcaemia 80.65 11.57 306 302660 15162 34638803
Poisoning 79.96 11.57 7 302959 12219 34641746
Neurotoxicity 79.29 11.57 338 302628 17672 34636293
Hyperkalaemia 78.37 11.57 322 302644 69067 34584898
Acute lymphocytic leukaemia 78.21 11.57 113 302853 2916 34651049
Lymphopenia 77.75 11.57 314 302652 16021 34637944
Posterior reversible encephalopathy syndrome 76.99 11.57 225 302741 9729 34644236
Colitis ulcerative 76.34 11.57 24 302942 16496 34637469
Body height decreased 76.30 11.57 127 302839 3716 34650249
Surgery 76.19 11.57 15 302951 14142 34639823
Contraindicated product administered 75.90 11.57 46 302920 21435 34632530
Parainfluenzae virus infection 75.16 11.57 107 302859 2723 34651242
Ageusia 74.99 11.57 228 302738 10080 34643885
Diffuse large B-cell lymphoma refractory 74.43 11.57 72 302894 1194 34652771
Respiratory tract infection 73.36 11.57 352 302614 19360 34634605
Wheezing 72.95 11.57 156 302810 41246 34612719
Sleep apnoea syndrome 72.52 11.57 43 302923 20278 34633687
Labelled drug-drug interaction medication error 72.14 11.57 20 302946 14919 34639046
Acute lymphocytic leukaemia recurrent 72.03 11.57 109 302857 2935 34651030
Respiratory arrest 71.99 11.57 82 302884 27961 34626004
Blood pressure systolic increased 71.97 11.57 56 302910 22896 34631069
Medication error 70.95 11.57 70 302896 25495 34628470
Abnormal behaviour 70.89 11.57 67 302899 24902 34629063
Erectile dysfunction 70.42 11.57 46 302920 20591 34633374
Treatment noncompliance 70.17 11.57 84 302882 28016 34625949
Stomatitis 70.16 11.57 618 302348 41896 34612069
Accidental overdose 69.95 11.57 44 302922 20096 34633869
Drug ineffective for unapproved indication 68.64 11.57 395 302571 23320 34630645
Acute myeloid leukaemia 68.53 11.57 327 302639 17943 34636022
Injury 68.07 11.57 48 302918 20639 34633326
Hypogammaglobulinaemia 67.76 11.57 183 302783 7557 34646408
Bone pain 66.85 11.57 355 302611 20331 34633634
Product quality issue 66.73 11.57 32 302934 17003 34636962
Cataract 66.15 11.57 421 302545 25765 34628200
Respiratory depression 65.99 11.57 29 302937 16216 34637749
Neoplasm progression 65.43 11.57 385 302581 22915 34631050
Pathological fracture 65.33 11.57 128 302838 4263 34649702
Sopor 65.02 11.57 13 302953 12123 34641842
Dyskinesia 64.98 11.57 59 302907 22354 34631611
Hallucination, visual 64.41 11.57 37 302929 17754 34636211
Obstructive airways disorder 62.41 11.57 28 302938 15466 34638499
Metabolic acidosis 61.88 11.57 184 302782 43496 34610469
Product substitution issue 60.37 11.57 8 302958 10087 34643878
Large intestine perforation 59.92 11.57 186 302780 8317 34645648
Chest pain 59.87 11.57 757 302209 126005 34527960
Lower respiratory tract infection 59.72 11.57 474 302492 31163 34622802
Cushingoid 58.37 11.57 93 302873 2621 34651344
Melaena 57.71 11.57 139 302827 35241 34618724
Osteolysis 57.18 11.57 100 302866 3048 34650917
Infusion related reaction 57.06 11.57 707 302259 52350 34601615
Gastrointestinal haemorrhage 56.61 11.57 492 302474 87985 34565980
Pneumonia influenzal 56.50 11.57 68 302898 1460 34652505
Nightmare 56.42 11.57 27 302939 14364 34639601
Injection site erythema 56.23 11.57 34 302932 15865 34638100
Foetal exposure during pregnancy 55.80 11.57 158 302808 37943 34616022
Bone disorder 55.47 11.57 148 302818 6067 34647898
Palpitations 54.81 11.57 171 302795 39815 34614150
Spinal cord compression 54.51 11.57 112 302854 3863 34650102
Asthenia 54.34 11.57 2622 300344 242629 34411336
H1N1 influenza 53.37 11.57 53 302913 909 34653056
Ventricular tachycardia 53.03 11.57 93 302873 26486 34627479
Eosinophilia 53.01 11.57 91 302875 26131 34627834
Eczema 52.89 11.57 49 302917 18387 34635578
Disseminated aspergillosis 52.85 11.57 48 302918 732 34653233
Injection site swelling 52.81 11.57 17 302949 11510 34642455
Agitation 52.68 11.57 287 302679 57112 34596853
Muscle spasms 52.54 11.57 928 302038 74073 34579892
Obesity 52.30 11.57 23 302943 12855 34641110
Hepatic cirrhosis 52.10 11.57 44 302922 17270 34636695
Akathisia 52.07 11.57 5 302961 8104 34645861
Respiratory failure 51.97 11.57 1270 301696 107302 34546663
Glycosylated haemoglobin increased 51.61 11.57 17 302949 11343 34642622
Spinal fracture 50.98 11.57 162 302804 7336 34646629
Dizziness 50.97 11.57 1473 301493 217048 34436917
Fear 50.63 11.57 14 302952 10462 34643503
Candida infection 50.57 11.57 294 302672 17421 34636544
Disseminated cryptococcosis 50.14 11.57 61 302905 1325 34652640
Full blood count increased 49.68 11.57 49 302917 833 34653132
Injection site haemorrhage 49.22 11.57 12 302954 9756 34644209
Heart rate decreased 49.22 11.57 128 302838 31617 34622348
Pemphigoid 49.20 11.57 8 302958 8658 34645307
Embolism 48.60 11.57 164 302802 7665 34646300
Gynaecomastia 48.47 11.57 14 302952 10166 34643799
Influenza 48.42 11.57 650 302316 49016 34604949
Drug level increased 48.12 11.57 73 302893 22023 34631942
Depressed level of consciousness 47.61 11.57 200 302766 42641 34611324
Myelopathy 47.56 11.57 81 302885 2416 34651549
Torsade de pointes 47.49 11.57 4 302962 7205 34646760
Device issue 47.38 11.57 13 302953 9764 34644201
B precursor type acute leukaemia 47.05 11.57 27 302939 188 34653777
Infective pulmonary exacerbation of cystic fibrosis 47.01 11.57 3 302963 6798 34647167
Microsporidia infection 46.96 11.57 43 302923 663 34653302
Progressive multifocal leukoencephalopathy 46.71 11.57 188 302778 9576 34644389
Device malfunction 46.63 11.57 16 302950 10405 34643560
Haematochezia 46.47 11.57 226 302740 46308 34607657
Choroiditis 46.45 11.57 55 302911 1160 34652805
Therapeutic response shortened 46.42 11.57 5 302961 7399 34646566
Substance abuse 45.82 11.57 6 302960 7635 34646330
Cytomegalovirus infection reactivation 45.80 11.57 122 302844 4996 34648969
C-reactive protein abnormal 45.28 11.57 10 302956 8700 34645265
Arthritis 45.15 11.57 131 302835 31215 34622750
Product administration error 45.07 11.57 45 302921 16299 34637666
Loss of consciousness 44.70 11.57 479 302487 82188 34571777
Abdominal pain 44.68 11.57 1078 301888 162540 34491425
Substance-induced psychotic disorder 43.65 11.57 64 302902 1674 34652291
Pneumonia bacterial 43.45 11.57 211 302755 11661 34642304
Pulmonary mucormycosis 43.18 11.57 43 302923 740 34653225
Frequent bowel movements 42.96 11.57 29 302937 12758 34641207
Red blood cell sedimentation rate increased 42.89 11.57 13 302953 9149 34644816
Rectal haemorrhage 42.83 11.57 191 302775 40058 34613907
Ocular hypertension 42.27 11.57 44 302922 800 34653165
Minimal residual disease 42.23 11.57 33 302933 404 34653561
Visceral leishmaniasis 42.13 11.57 38 302928 574 34653391
Hypertension 42.06 11.57 882 302084 135561 34518404
Systemic candida 41.99 11.57 97 302869 3629 34650336
Therapeutic product effect incomplete 41.95 11.57 261 302705 50280 34603685
Emotional distress 41.86 11.57 41 302925 14985 34638980
Spinal compression fracture 41.50 11.57 146 302820 6970 34646995
Hepatitis B reactivation 41.35 11.57 99 302867 3792 34650173
Pain in extremity 41.32 11.57 810 302156 125703 34528262
Neutropenic colitis 41.25 11.57 87 302879 3057 34650908
Atrial fibrillation 41.14 11.57 1369 301597 121024 34532941
Parkinsonism 41.00 11.57 10 302956 8128 34645837
Bacterial sepsis 40.92 11.57 119 302847 5131 34648834
Delusion 40.67 11.57 30 302936 12605 34641360
Injection site reaction 40.61 11.57 32 302934 13001 34640964
Amyloidosis 40.61 11.57 69 302897 2054 34651911
Gastrooesophageal reflux disease 40.33 11.57 180 302786 37744 34616221
Underdose 40.27 11.57 36 302930 13744 34640221
Injection site mass 40.23 11.57 5 302961 6621 34647344
Prescribed overdose 40.20 11.57 21 302945 10626 34643339
Adenocarcinoma of colon 40.12 11.57 90 302876 3301 34650664
Ventricular fibrillation 40.00 11.57 87 302879 22867 34631098
Therapeutic product effect decreased 39.98 11.57 160 302806 34583 34619382
Product use in unapproved indication 39.94 11.57 1316 301650 116183 34537782
Peripheral motor neuropathy 39.86 11.57 63 302903 1763 34652202
Device leakage 39.82 11.57 5 302961 6570 34647395
Visual acuity reduced 39.78 11.57 258 302708 15891 34638074
Cardiac failure congestive 39.76 11.57 496 302470 82774 34571191
Panic attack 39.66 11.57 16 302950 9416 34644549
Hyperhidrosis 39.56 11.57 442 302524 75250 34578715
Injection site bruising 39.29 11.57 13 302953 8650 34645315
Autonomic neuropathy 39.28 11.57 45 302921 915 34653050
Escherichia sepsis 38.97 11.57 109 302857 4595 34649370
Cardiac murmur 38.77 11.57 10 302956 7827 34646138
Hallucination, auditory 38.75 11.57 28 302938 11889 34642076
Aspergillus infection 38.71 11.57 209 302757 12045 34641920
Nephrolithiasis 38.62 11.57 134 302832 30199 34623766
Drug ineffective 38.61 11.57 3422 299544 453329 34200636
Febrile infection 38.57 11.57 69 302897 2142 34651823
Injection site pruritus 38.43 11.57 7 302959 6976 34646989
Staphylococcal bacteraemia 38.27 11.57 160 302806 8292 34645673
Coronary artery occlusion 37.99 11.57 24 302942 10938 34643027
Exposure during pregnancy 37.82 11.57 15 302951 8919 34645046
Malignant neoplasm of unknown primary site 37.75 11.57 30 302936 377 34653588
Sexual dysfunction 37.68 11.57 5 302961 6298 34647667
Skin striae 37.51 11.57 36 302930 591 34653374
Dystonia 37.24 11.57 24 302942 10821 34643144
Miosis 37.21 11.57 18 302948 9517 34644448
Bladder cancer 37.19 11.57 52 302914 16226 34637739
Pneumonia escherichia 37.16 11.57 31 302935 419 34653546
Paranoia 37.14 11.57 30 302936 12038 34641927
Osteoarthritis 37.01 11.57 77 302889 20565 34633400
Corneal decompensation 36.87 11.57 12 302954 12 34653953
Ulcerative keratitis 36.85 11.57 59 302907 1670 34652295
Type 2 diabetes mellitus 36.84 11.57 51 302915 15981 34637984
Aplasia 36.73 11.57 105 302861 4483 34649482
Transplant rejection 36.53 11.57 22 302944 10289 34643676
Pseudomonas infection 36.32 11.57 207 302759 12175 34641790
Lip swelling 36.11 11.57 52 302914 16028 34637937
Psychotic disorder 36.09 11.57 101 302865 24351 34629614
Ischaemic cardiomyopathy 36.04 11.57 6 302960 6383 34647582
Pulmonary thrombosis 35.74 11.57 143 302823 7264 34646701
Disturbance in attention 35.52 11.57 111 302855 25834 34628131
Meningitis pneumococcal 35.43 11.57 23 302943 205 34653760
Aeromonas infection 35.42 11.57 25 302941 259 34653706
Mobility decreased 35.14 11.57 138 302828 29990 34623975
Diverticular perforation 35.02 11.57 86 302880 3348 34650617
Compression fracture 34.99 11.57 80 302886 2972 34650993
Middle insomnia 34.98 11.57 8 302958 6794 34647171
Adrenal insufficiency 34.95 11.57 225 302741 13822 34640143
Malaise 34.87 11.57 1288 301678 184537 34469428
Primary amyloidosis 34.74 11.57 19 302947 119 34653846
Hyperlipidaemia 34.63 11.57 45 302921 14484 34639481
Ankylosing spondylitis 34.59 11.57 4 302962 5600 34648365
Sleep disorder due to a general medical condition 34.11 11.57 3 302963 5218 34648747
Blood cholesterol increased 34.06 11.57 80 302886 20463 34633502
Metastases to central nervous system 33.83 11.57 151 302815 8054 34645911
Cardio-respiratory arrest 33.74 11.57 311 302655 54962 34599003
Drug level decreased 33.50 11.57 13 302953 7833 34646132
Dehydration 33.39 11.57 1411 301555 128558 34525407
Accidental exposure to product 33.33 11.57 37 302929 12765 34641200
Pruritus 33.32 11.57 956 302010 141025 34512940
Infection reactivation 33.14 11.57 52 302914 1446 34652519
Chronic kidney disease 33.07 11.57 215 302751 40995 34612970
Swollen tongue 33.03 11.57 47 302919 14558 34639407
Refractory anaemia with an excess of blasts 32.94 11.57 28 302938 389 34653576
Bradycardia 32.80 11.57 458 302508 74960 34579005
Fall 32.74 11.57 1431 301535 201454 34452511
Kidney transplant rejection 32.71 11.57 12 302954 7485 34646480
Extrapyramidal disorder 32.69 11.57 38 302928 12842 34641123
Multiple organ dysfunction syndrome 32.62 11.57 882 302084 75684 34578281
Pneumonia fungal 32.61 11.57 135 302831 6965 34647000
Toxicity to various agents 32.58 11.57 1412 301554 198950 34455015
Muscle rigidity 32.55 11.57 26 302940 10492 34643473
Disseminated mucormycosis 32.29 11.57 31 302935 509 34653456
Hypertriglyceridaemia 32.26 11.57 152 302814 8296 34645669
Road traffic accident 32.21 11.57 64 302902 17386 34636579
Product storage error 32.21 11.57 15 302951 8107 34645858
Haematuria 32.18 11.57 278 302688 49788 34604177
Mitral valve incompetence 31.93 11.57 50 302916 14893 34639072
Refractory cytopenia with multilineage dysplasia 31.76 11.57 18 302948 122 34653843
Anhedonia 31.67 11.57 13 302953 7572 34646393
Cataract subcapsular 31.54 11.57 27 302939 379 34653586
Abdominal discomfort 31.42 11.57 349 302617 59486 34594479
Immunosuppressant drug level increased 31.38 11.57 7 302959 6048 34647917
Hyperviscosity syndrome 31.29 11.57 21 302945 199 34653766
Taste disorder 31.27 11.57 134 302832 7021 34646944
JC virus infection 31.21 11.57 63 302903 2145 34651820
Peripheral sensorimotor neuropathy 31.03 11.57 52 302914 1530 34652435
Protein total increased 30.84 11.57 64 302902 2223 34651742
Benign prostatic hyperplasia 30.50 11.57 49 302917 14446 34639519
Incorrect route of product administration 30.48 11.57 51 302915 14794 34639171
Myasthenia gravis 30.46 11.57 11 302955 6929 34647036
Acute kidney injury 30.44 11.57 2254 300712 302734 34351231
Atrial septal defect 30.34 11.57 13 302953 7379 34646586
Mantle cell lymphoma recurrent 29.94 11.57 35 302931 728 34653237
Back pain 29.89 11.57 1316 301650 120473 34533492
Cholestasis 29.82 11.57 126 302840 26822 34627143
Paraplegia 29.79 11.57 73 302893 2838 34651127
Cardiogenic shock 29.73 11.57 124 302842 26494 34627471
Cellulitis enterococcal 29.68 11.57 16 302950 97 34653868
Pulmonary function test decreased 29.61 11.57 4 302962 4971 34648994
Blood phosphorus increased 29.49 11.57 15 302951 7706 34646259
Vertebral lesion 29.33 11.57 20 302946 195 34653770
Anger 29.16 11.57 36 302930 11848 34642117
Tricuspid valve incompetence 29.12 11.57 25 302941 9735 34644230
Coronary artery bypass 29.04 11.57 4 302962 4898 34649067
Blood lactate dehydrogenase increased 29.01 11.57 316 302650 22674 34631291
Pneumonia pneumococcal 28.88 11.57 60 302906 2086 34651879
Joint stiffness 28.78 11.57 31 302935 10842 34643123
Pneumonia viral 28.75 11.57 76 302890 3098 34650867
Arteriosclerosis 28.59 11.57 37 302929 11931 34642034
Syringe issue 28.46 11.57 7 302959 5657 34648308
Monoclonal immunoglobulin increased 28.43 11.57 18 302948 153 34653812
Atypical haemolytic uraemic syndrome 28.12 11.57 23 302943 302 34653663
B-cell type acute leukaemia 28.05 11.57 23 302943 303 34653662
Basal cell carcinoma 28.02 11.57 277 302689 19381 34634584
Dyslipidaemia 27.93 11.57 15 302951 7473 34646492
Tendonitis 27.78 11.57 23 302943 9117 34644848
Obsessive-compulsive disorder 27.72 11.57 7 302959 5557 34648408
Clostridium difficile colitis 27.69 11.57 232 302734 15498 34638467
Drug reaction with eosinophilia and systemic symptoms 27.63 11.57 170 302796 32842 34621123
Herpes simplex reactivation 27.63 11.57 13 302953 56 34653909
Viral haemorrhagic cystitis 27.56 11.57 42 302924 1138 34652827
Haematoma 27.55 11.57 121 302845 25484 34628481
Alcohol abuse 27.38 11.57 4 302962 4686 34649279
Cellulitis orbital 27.33 11.57 23 302943 315 34653650
Salivary hypersecretion 27.21 11.57 21 302945 8623 34645342
Pulmonary fibrosis 27.14 11.57 76 302890 18320 34635645
Familial periodic paralysis 27.06 11.57 14 302952 77 34653888
Blood loss anaemia 26.97 11.57 19 302947 8175 34645790
Hypertransaminasaemia 26.86 11.57 108 302858 5498 34648467
Pasteurella infection 26.86 11.57 11 302955 31 34653934
Enthesopathy 26.77 11.57 4 302962 4609 34649356
Joint range of motion decreased 26.76 11.57 15 302951 7297 34646668
Herpes zoster 26.76 11.57 433 302533 33966 34619999
Ascites 26.74 11.57 266 302700 46305 34607660
Gait disturbance 26.61 11.57 549 302417 84591 34569374
Cardiomegaly 26.50 11.57 59 302907 15379 34638586
Arteriosclerosis coronary artery 26.47 11.57 42 302924 12443 34641522
Cardiac failure chronic 26.29 11.57 18 302948 7861 34646104
Pneumonitis 26.19 11.57 426 302540 33452 34620513
Coombs positive haemolytic anaemia 26.18 11.57 37 302929 935 34653030
Dermatitis atopic 26.11 11.57 7 302959 5340 34648625
Blood triglycerides increased 26.07 11.57 52 302914 14107 34639858
Discomfort 25.94 11.57 81 302885 18857 34635108
Sputum discoloured 25.86 11.57 18 302948 7794 34646171
Heart rate irregular 25.85 11.57 62 302904 15745 34638220
Chronic obstructive pulmonary disease 25.81 11.57 285 302681 48633 34605332
Meningitis bacterial 25.69 11.57 43 302923 1264 34652701
Urticaria 25.65 11.57 383 302583 61994 34591971
Intestinal perforation 25.62 11.57 150 302816 8910 34645055
Paraproteinaemia 25.52 11.57 23 302943 347 34653618
Dry mouth 25.43 11.57 155 302811 30010 34623955
Escherichia bacteraemia 25.23 11.57 74 302892 3206 34650759
Disseminated strongyloidiasis 25.22 11.57 18 302948 190 34653775
Large intestine polyp 25.20 11.57 19 302947 7895 34646070
Blood pressure measurement 25.17 11.57 17 302949 163 34653802
Liver function test abnormal 24.99 11.57 162 302804 30912 34623053
Decreased appetite 24.81 11.57 1717 301249 164675 34489290
Enterocolitis infectious 24.72 11.57 49 302917 1646 34652319
Ureteric compression 24.61 11.57 20 302946 260 34653705
Iron deficiency anaemia 24.61 11.57 32 302934 10297 34643668
Complications of transplanted kidney 24.56 11.57 5 302961 4604 34649361
Crying 24.55 11.57 10 302956 5852 34648113
Hypocalcaemia 24.54 11.57 320 302646 23969 34629996
Gastric perforation 24.53 11.57 62 302904 2458 34651507
Cardiac amyloidosis 24.38 11.57 41 302925 1210 34652755
Ecthyma 24.35 11.57 25 302941 447 34653518
Light chain disease 24.33 11.57 15 302951 121 34653844
Hypotony of eye 24.33 11.57 14 302952 98 34653867
Cerebral haemorrhage 24.27 11.57 190 302776 34747 34619218
Performance status decreased 24.23 11.57 85 302881 4052 34649913
Cytomegalovirus infection 24.22 11.57 339 302627 25796 34628169
Depressed mood 24.14 11.57 86 302880 19231 34634734
Immune effector cell-associated neurotoxicity syndrome 24.13 11.57 79 302887 3634 34650331
Tubulointerstitial nephritis 24.07 11.57 97 302869 20927 34633038
Blood immunoglobulin G increased 23.94 11.57 35 302931 913 34653052
Hypokinesia 23.86 11.57 25 302941 8855 34645110
Blood calcium increased 23.84 11.57 77 302889 3517 34650448
Dysentery 23.83 11.57 22 302944 343 34653622
Faeces discoloured 23.82 11.57 59 302907 14819 34639146
Cerebral venous thrombosis 23.80 11.57 31 302935 723 34653242
B-cell lymphoma recurrent 23.75 11.57 32 302934 772 34653193
Blood potassium increased 23.71 11.57 69 302897 16426 34637539
Neoplasm recurrence 23.66 11.57 57 302909 2192 34651773
Metapneumovirus infection 23.60 11.57 32 302934 777 34653188
Atrial flutter 23.45 11.57 222 302744 15352 34638613
Negative pressure pulmonary oedema 23.40 11.57 18 302948 215 34653750
Blood immunoglobulin M increased 23.26 11.57 19 302947 249 34653716
Meningitis cryptococcal 23.25 11.57 59 302907 2345 34651620
Exercise tolerance decreased 23.23 11.57 8 302958 5190 34648775
Respiratory rate increased 23.21 11.57 31 302935 9863 34644102
Muscle spasticity 23.15 11.57 11 302955 5877 34648088
Enterococcal infection 23.12 11.57 149 302817 9157 34644808
Heart block congenital 23.05 11.57 10 302956 34 34653931
Pallor 23.04 11.57 128 302838 25352 34628613
Immunosuppression 23.04 11.57 112 302854 6192 34647773
Pulmonary arterial hypertension 23.03 11.57 25 302941 8714 34645251
Rectal adenocarcinoma 23.02 11.57 32 302934 796 34653169
Angina pectoris 23.00 11.57 168 302798 31195 34622770
Blood pressure diastolic decreased 22.90 11.57 27 302939 9067 34644898
Electrocardiogram QRS complex prolonged 22.81 11.57 7 302959 4887 34649078
Gallbladder oedema 22.79 11.57 18 302948 224 34653741
Central nervous system vasculitis 22.78 11.57 25 302941 484 34653481
Myocardial ischaemia 22.77 11.57 76 302890 17332 34636633
Bronchiectasis 22.70 11.57 31 302935 9770 34644195
Coronary artery stenosis 22.69 11.57 30 302936 9586 34644379
Peripheral swelling 22.68 11.57 844 302122 75697 34578268
Necrotising retinitis 22.60 11.57 32 302934 810 34653155
Platelet count abnormal 22.55 11.57 66 302900 2856 34651109
Steroid withdrawal syndrome 22.53 11.57 18 302948 228 34653737
Restlessness 22.50 11.57 129 302837 25353 34628612
Dyspnoea exertional 22.49 11.57 253 302713 43026 34610939
Hordeolum 22.30 11.57 36 302930 1026 34652939
Cystitis haemorrhagic 22.28 11.57 103 302863 5576 34648389
Blood pressure diastolic abnormal 22.26 11.57 7 302959 4811 34649154
Mydriasis 22.26 11.57 18 302948 7219 34646746
Guillain-Barre syndrome 22.14 11.57 108 302858 5979 34647986
Nephrogenic systemic fibrosis 22.07 11.57 4 302962 4001 34649964
Eosinophil count increased 22.07 11.57 25 302941 8547 34645418
Oral candidiasis 22.06 11.57 180 302786 11930 34642035
Needle issue 22.06 11.57 13 302953 6152 34647813
Diabetic ketoacidosis 22.06 11.57 81 302885 17951 34636014
Renal amyloidosis 21.96 11.57 12 302954 75 34653890
Second primary malignancy 21.94 11.57 130 302836 7756 34646209
Blood immunoglobulin A increased 21.92 11.57 20 302946 307 34653658
Human herpesvirus 6 encephalitis 21.91 11.57 21 302945 344 34653621
Disability 21.88 11.57 7 302959 4758 34649207
Exposure to toxic agent 21.77 11.57 3 302963 3672 34650293
Pulmonary congestion 21.72 11.57 55 302911 13710 34640255
Peritonitis bacterial 21.70 11.57 13 302953 6097 34647868
Product complaint 21.68 11.57 12 302954 5878 34648087
Electrocardiogram abnormal 21.67 11.57 29 302937 9218 34644747
Blood pressure systolic abnormal 21.63 11.57 4 302962 3944 34650021
Blood urea increased 21.62 11.57 164 302802 30200 34623765
Haemorrhage 21.61 11.57 314 302652 51056 34602909
Rhinovirus infection 21.55 11.57 84 302882 4215 34649750
Product dose omission issue 21.48 11.57 834 302132 118877 34535088
Body temperature decreased 21.41 11.57 51 302915 12983 34640982
Hydrocephalus 21.35 11.57 96 302870 5136 34648829
Vascular pain 21.28 11.57 15 302951 155 34653810
Joint injury 21.26 11.57 29 302937 9144 34644821
Influenza like illness 21.25 11.57 146 302820 27488 34626477
Umbilical hernia 21.24 11.57 7 302959 4670 34649295
Sleep disorder 21.24 11.57 174 302792 31514 34622451
Pancreatitis 21.15 11.57 225 302741 38666 34615299
Keratopathy 21.11 11.57 27 302939 618 34653347
Staphylococcal sepsis 21.11 11.57 152 302814 9692 34644273
Withdrawal syndrome 21.05 11.57 48 302918 12407 34641558
Haematemesis 21.02 11.57 147 302819 27564 34626401
Bacterial infection 20.82 11.57 233 302733 16830 34637135
Hypoxia 20.78 11.57 625 302341 54470 34599495
Stent placement 20.73 11.57 9 302957 5069 34648896
Gastric ulcer 20.69 11.57 68 302898 15582 34638383
Memory impairment 20.67 11.57 258 302708 43060 34610905
Intercepted product preparation error 20.57 11.57 5 302961 4073 34649892
Therapeutic response unexpected 20.51 11.57 33 302933 9724 34644241
Joint swelling 20.28 11.57 381 302585 59509 34594456
C-reactive protein increased 20.28 11.57 338 302628 53760 34600205
Taeniasis 20.24 11.57 10 302956 49 34653916
Foot deformity 20.24 11.57 7 302959 4530 34649435
Varices oesophageal 20.16 11.57 4 302962 3751 34650214
Priapism 20.15 11.57 9 302957 4985 34648980
Lymphocytic leukaemia 20.07 11.57 15 302951 171 34653794
Upper gastrointestinal haemorrhage 20.03 11.57 134 302832 25384 34628581
Venous thrombosis limb 20.00 11.57 50 302916 1969 34651996
Systemic lupus erythematosus 19.93 11.57 4 302962 3720 34650245
Keratitis bacterial 19.85 11.57 11 302955 71 34653894
Allergy test negative 19.83 11.57 13 302953 118 34653847
Rash pruritic 19.80 11.57 336 302630 26605 34627360
Glioblastoma 19.70 11.57 34 302932 1025 34652940
Bacillus infection 19.69 11.57 18 302948 277 34653688
Angina unstable 19.62 11.57 45 302921 11608 34642357
Cerebral toxoplasmosis 19.61 11.57 45 302921 1676 34652289
Pneumonia parainfluenzae viral 19.60 11.57 14 302952 148 34653817
Diabetes mellitus inadequate control 19.58 11.57 56 302910 13408 34640557
Lymphoid tissue hypoplasia 19.53 11.57 21 302945 397 34653568
Thymus hypoplasia 19.53 11.57 21 302945 397 34653568
Light chain analysis abnormal 19.47 11.57 13 302953 122 34653843
Malignant transformation 19.47 11.57 30 302936 821 34653144
Blood stem cell transplant failure 19.36 11.57 21 302945 401 34653564
Blood glucose decreased 19.29 11.57 55 302911 13182 34640783
Autoimmune lymphoproliferative syndrome 19.29 11.57 14 302952 152 34653813
Psychomotor skills impaired 19.29 11.57 5 302961 3901 34650064
Varicella zoster virus infection 19.24 11.57 46 302920 1760 34652205
Impaired work ability 19.20 11.57 19 302947 6911 34647054
Bradykinesia 19.20 11.57 5 302961 3888 34650077
Fungal sepsis 19.13 11.57 30 302936 834 34653131
Skin plaque 19.12 11.57 8 302958 4606 34649359
Differentiation syndrome 19.11 11.57 40 302926 1398 34652567
Colitis 19.07 11.57 445 302521 37305 34616660
Klebsiella infection 19.03 11.57 133 302833 8398 34645567
Pulmonary hypertension 18.98 11.57 105 302861 20819 34633146
Hiatus hernia 18.93 11.57 23 302943 7622 34646343
Pseudomyopia 18.91 11.57 9 302957 40 34653925
Renal cyst 18.89 11.57 31 302935 9062 34644903
Nocardiosis 18.84 11.57 76 302890 3875 34650090
Mental disorder 18.81 11.57 68 302898 15141 34638824
Cardiac arrest 18.79 11.57 663 302303 95496 34558469
Actinomycosis 18.77 11.57 22 302944 459 34653506
Anaphylactic shock 18.69 11.57 216 302750 15725 34638240
Tuberculosis of central nervous system 18.65 11.57 15 302951 192 34653773
Neck pain 18.48 11.57 136 302830 25213 34628752
Therapy interrupted 18.47 11.57 59 302907 13638 34640327
Oroantral fistula 18.46 11.57 15 302951 195 34653770
Metastatic malignant melanoma 18.40 11.57 49 302917 2006 34651959
Hepatic cancer 18.35 11.57 27 302939 8248 34645717
Pulmonary sepsis 18.29 11.57 52 302914 2213 34651752
Intraocular pressure decreased 18.24 11.57 10 302956 63 34653902
Irritability 18.23 11.57 132 302834 24558 34629407
Productive cough 18.12 11.57 225 302741 37588 34616377
Drug-induced liver injury 18.12 11.57 161 302805 28671 34625294
Chronic inflammatory demyelinating polyradiculoneuropathy 18.09 11.57 27 302939 718 34653247
Forced expiratory volume decreased 18.09 11.57 3 302963 3200 34650765
Disorientation 18.04 11.57 192 302774 32996 34620969
Phrenic nerve paralysis 18.03 11.57 12 302954 112 34653853
Streptococcal bacteraemia 18.00 11.57 48 302918 1967 34651998
Lactose intolerance 17.97 11.57 37 302929 1278 34652687
Orthopnoea 17.92 11.57 11 302955 5092 34648873
Seasonal allergy 17.90 11.57 109 302857 6566 34647399
Lymphadenitis 17.80 11.57 48 302918 1980 34651985
Septic embolus 17.77 11.57 36 302930 1229 34652736
Periorbital infection 17.70 11.57 13 302953 144 34653821
Hypothermia 17.70 11.57 42 302924 10706 34643259
Cavernous sinus thrombosis 17.68 11.57 14 302952 175 34653790
Choroidal detachment 17.64 11.57 20 302946 402 34653563
Listeriosis 17.60 11.57 32 302934 1006 34652959
Cerebral haematoma 17.58 11.57 9 302957 4606 34649359
Hypoalbuminaemia 17.57 11.57 172 302794 12002 34641963
Hepatitis cholestatic 17.55 11.57 26 302940 7921 34646044
Corneal abscess 17.54 11.57 7 302959 18 34653947
Jugular vein thrombosis 17.54 11.57 43 302923 1672 34652293
Respirovirus test positive 17.50 11.57 10 302956 69 34653896
Neurological decompensation 17.42 11.57 61 302905 2905 34651060
Psychomotor retardation 17.41 11.57 5 302961 3645 34650320
Blood creatinine increased 17.40 11.57 660 302306 94316 34559649
Renal cancer 17.38 11.57 25 302941 7710 34646255
Vitamin D deficiency 17.31 11.57 19 302947 6589 34647376
Necrotising fasciitis 17.27 11.57 71 302895 3651 34650314
Dysgeusia 17.18 11.57 324 302642 26173 34627792
Stem cell transplant 17.17 11.57 49 302917 2090 34651875
Joint effusion 17.15 11.57 12 302954 5181 34648784
Implantation complication 17.12 11.57 6 302960 9 34653956
Cryptococcosis 17.12 11.57 53 302913 2366 34651599
Colorectal cancer 17.09 11.57 10 302956 4751 34649214
Altered state of consciousness 17.09 11.57 122 302844 22771 34631194
Poor venous access 17.08 11.57 12 302954 5171 34648794
Hyperbilirubinaemia 17.06 11.57 222 302744 16621 34637344
Expired product administered 17.04 11.57 4 302962 3337 34650628
Eastern Cooperative Oncology Group performance status worsened 17.00 11.57 31 302935 977 34652988
Multiple allergies 16.99 11.57 61 302905 2942 34651023
Photosensitivity reaction 16.97 11.57 42 302924 10552 34643413
Protein total abnormal 16.96 11.57 18 302948 335 34653630
Hypopyon 16.95 11.57 19 302947 377 34653588
Inflammation 16.92 11.57 160 302806 28135 34625830
Hyponatraemia 16.88 11.57 567 302399 82124 34571841
Neutropenic infection 16.88 11.57 39 302927 1459 34652506
Glioblastoma multiforme 16.86 11.57 26 302940 712 34653253
Myoclonus 16.82 11.57 68 302898 14657 34639308
Migraine 16.80 11.57 86 302880 17392 34636573
Knee arthroplasty 16.79 11.57 24 302942 7420 34646545
Corneal perforation 16.74 11.57 14 302952 190 34653775
Hepatic steatosis 16.73 11.57 92 302874 18270 34635695
Hepatic encephalopathy 16.65 11.57 68 302898 14617 34639348
Subarachnoid haemorrhage 16.64 11.57 55 302911 12580 34641385
Chromaturia 16.62 11.57 67 302899 14453 34639512
Transient ischaemic attack 16.57 11.57 156 302810 27457 34626508
Fungal oesophagitis 16.56 11.57 19 302947 387 34653578
Abnormal dreams 16.53 11.57 25 302941 7553 34646412
Hepatic cytolysis 16.52 11.57 67 302899 14429 34639536
Product dispensing error 16.48 11.57 18 302948 6256 34647709
Blood pressure decreased 16.44 11.57 331 302635 51184 34602781
Syncope 16.42 11.57 637 302329 90814 34563151
Posterior capsule rupture 16.39 11.57 6 302960 11 34653954
Testicular germ cell cancer metastatic 16.38 11.57 9 302957 57 34653908
Escherichia infection 16.36 11.57 125 302841 8120 34645845
Ejection fraction decreased 16.36 11.57 98 302868 19056 34634909
Retinal vein thrombosis 16.33 11.57 19 302947 393 34653572
Hypercholesterolaemia 16.29 11.57 32 302934 8730 34645235
Dysarthria 16.28 11.57 208 302758 34574 34619391
Clostridium difficile infection 16.27 11.57 242 302724 18656 34635309
Thrombotic microangiopathy 16.24 11.57 152 302814 10478 34643487
Back disorder 16.22 11.57 106 302860 6545 34647420
Bundle branch block right 16.20 11.57 25 302941 7491 34646474
Nasal congestion 16.20 11.57 125 302841 22932 34631033
Encephalitis brain stem 16.19 11.57 10 302956 81 34653884
Musculoskeletal pain 16.16 11.57 188 302778 31775 34622190
Euglycaemic diabetic ketoacidosis 16.15 11.57 4 302962 3218 34650747
Nervous system disorder 16.15 11.57 195 302771 14348 34639617
Device related infection 16.14 11.57 224 302742 17013 34636952
Atypical pneumonia 16.10 11.57 65 302901 3315 34650650
Post procedural complication 16.10 11.57 48 302918 11340 34642625
Eye pain 16.05 11.57 183 302783 13279 34640686
Secondary immunodeficiency 16.04 11.57 19 302947 401 34653564
Presyncope 16.03 11.57 98 302868 18961 34635004
Flushing 16.02 11.57 381 302585 32039 34621926
Drug level below therapeutic 16.01 11.57 15 302951 5600 34648365
Duodenal ulcer haemorrhage 16.01 11.57 12 302954 5001 34648964
Granulocytopenia 16.00 11.57 20 302946 6547 34647418
Acute respiratory distress syndrome 15.97 11.57 315 302651 25654 34628311
Keratitis fungal 15.97 11.57 12 302954 138 34653827
Rib fracture 15.95 11.57 193 302773 14207 34639758
Coordination abnormal 15.93 11.57 26 302940 7618 34646347
Body tinea 15.89 11.57 10 302956 84 34653881
Haemodialysis 15.89 11.57 43 302923 10483 34643482
Corneal lesion 15.88 11.57 7 302959 25 34653940
Refeeding syndrome 15.88 11.57 7 302959 25 34653940
Sternal fracture 15.84 11.57 24 302942 647 34653318
Seizure 15.78 11.57 745 302221 104112 34549853
Left ventricular hypertrophy 15.72 11.57 29 302937 8101 34645864
Jaw disorder 15.72 11.57 48 302918 2127 34651838
Spinal column injury 15.70 11.57 23 302943 601 34653364
Pericardial haemorrhage 15.68 11.57 4 302962 3154 34650811
Oral pain 15.64 11.57 153 302813 10674 34643291
Upper respiratory tract infection 15.58 11.57 386 302580 32673 34621292
Pseudomonal bacteraemia 15.54 11.57 37 302929 1412 34652553
Nerve injury 15.49 11.57 66 302900 3449 34650516
Injection site induration 15.45 11.57 3 302963 2857 34651108
White blood cell count increased 15.45 11.57 257 302709 40894 34613071
Depressive symptom 15.45 11.57 3 302963 2856 34651109
Normochromic normocytic anaemia 15.40 11.57 9 302957 4278 34649687
Aplastic anaemia 15.38 11.57 140 302826 9576 34644389
Lymphocyte adoptive therapy 15.36 11.57 5 302961 5 34653960
Hypothyroidism 15.31 11.57 112 302854 20790 34633175
Post procedural hypotension 15.30 11.57 9 302957 66 34653899
Hepatocellular carcinoma 15.23 11.57 26 302940 7483 34646482
Abdominal distension 15.22 11.57 388 302578 58104 34595861
Snoring 15.21 11.57 5 302961 3341 34650624
Status epilepticus 15.21 11.57 57 302909 12557 34641408
Pseudomonal sepsis 15.17 11.57 66 302900 3481 34650484
Cholelithiasis 15.16 11.57 114 302852 21034 34632931
Tooth deposit 15.14 11.57 10 302956 92 34653873
Non-small cell lung cancer 15.12 11.57 71 302895 3869 34650096
Adenoviral hepatitis 15.09 11.57 21 302945 523 34653442
Autologous haematopoietic stem cell transplant 15.04 11.57 8 302958 47 34653918
Speech disorder 15.04 11.57 146 302820 25540 34628425
VIIIth nerve lesion 15.03 11.57 4 302962 0 34653965
Fascial infection 15.03 11.57 4 302962 0 34653965
Long QT syndrome 15.02 11.57 3 302963 2800 34651165
Heart rate increased 15.02 11.57 297 302669 46046 34607919
Meibomian gland dysfunction 14.98 11.57 9 302957 69 34653896
Amoebic colitis 14.97 11.57 10 302956 94 34653871
Ventricular septal defect 14.94 11.57 8 302958 3993 34649972
Developmental delay 14.81 11.57 3 302963 2772 34651193
Alcohol use 14.80 11.57 5 302961 3283 34650682
Enterococcal bacteraemia 14.78 11.57 43 302923 1854 34652111
Drug specific antibody present 14.77 11.57 5 302961 3280 34650685
Aspiration 14.77 11.57 55 302911 12139 34641826
Haematoma muscle 14.74 11.57 35 302931 1333 34652632
Musculoskeletal chest pain 14.74 11.57 141 302825 9777 34644188
Lower gastrointestinal haemorrhage 14.73 11.57 38 302928 9414 34644551
Right ventricular failure 14.73 11.57 34 302932 8750 34645215
Amnesia 14.71 11.57 153 302813 26410 34627555
Oropharyngeal candidiasis 14.67 11.57 26 302940 801 34653164
Carotid artery occlusion 14.67 11.57 7 302959 3730 34650235
Lupus-like syndrome 14.66 11.57 3 302963 2753 34651212
Lentigo maligna 14.64 11.57 17 302949 351 34653614
Thinking abnormal 14.63 11.57 19 302947 6118 34647847
Radiation necrosis 14.60 11.57 11 302955 127 34653838
Aplasia pure red cell 14.60 11.57 19 302947 6113 34647852
Pneumonia necrotising 14.60 11.57 25 302941 749 34653216
Chalazion 14.58 11.57 12 302954 159 34653806
Corneal degeneration 14.55 11.57 7 302959 32 34653933
Bronchopneumopathy 14.55 11.57 20 302946 492 34653473
Steroid diabetes 14.54 11.57 47 302919 2148 34651817
Cryptococcal meningoencephalitis 14.53 11.57 11 302955 128 34653837
Candida pneumonia 14.49 11.57 19 302947 446 34653519
Neoplasm 14.49 11.57 89 302877 5378 34648587
Central nervous system leukaemia 14.48 11.57 15 302951 271 34653694
Asphyxia 14.48 11.57 23 302943 6812 34647153
Aspiration bone marrow abnormal 14.46 11.57 11 302955 129 34653836
Cataract cortical 14.46 11.57 9 302957 74 34653891
Squamous cell carcinoma of head and neck 14.46 11.57 12 302954 161 34653804
Head injury 14.44 11.57 95 302871 18065 34635900
Abdominal pain upper 14.40 11.57 491 302475 70999 34582966
Glaucoma 14.40 11.57 106 302860 6806 34647159
Exposed bone in jaw 14.39 11.57 38 302928 1548 34652417
Panophthalmitis 14.38 11.57 6 302960 18 34653947
Hepatitis B 14.38 11.57 95 302871 5888 34648077
Platelet disorder 14.38 11.57 40 302926 1681 34652284
Aortic valve incompetence 14.37 11.57 18 302948 5886 34648079
Disseminated coccidioidomycosis 14.36 11.57 9 302957 75 34653890
Disease recurrence 14.36 11.57 264 302702 21226 34632739
BK virus infection 14.33 11.57 92 302874 5646 34648319
Hypogeusia 14.32 11.57 28 302938 931 34653034
Gastritis 14.25 11.57 121 302845 21752 34632213
Congenital herpes simplex infection 14.22 11.57 7 302959 34 34653931
Hyperreflexia 14.21 11.57 5 302961 3201 34650764
Acidosis 14.17 11.57 48 302918 10897 34643068
Intervertebral disc degeneration 14.16 11.57 21 302945 6396 34647569
Immunoglobulins increased 14.15 11.57 14 302952 239 34653726
Gingivitis 14.15 11.57 65 302901 3510 34650455
SARS-CoV-2 RNA increased 14.14 11.57 6 302960 19 34653946
VIth nerve disorder 14.14 11.57 6 302960 19 34653946
Stress echocardiogram abnormal 14.08 11.57 5 302961 8 34653957
Vitreous loss 14.08 11.57 5 302961 8 34653957
Microangiopathic haemolytic anaemia 14.07 11.57 27 302939 885 34653080
Inflammatory bowel disease 13.93 11.57 4 302962 2916 34651049
Precursor B-lymphoblastic lymphoma 13.92 11.57 6 302960 20 34653945
Colorectal adenocarcinoma 13.91 11.57 13 302953 206 34653759
Impaired quality of life 13.88 11.57 18 302948 5800 34648165
Post procedural infection 13.82 11.57 13 302953 4843 34649122
Mucosal haemorrhage 13.80 11.57 38 302928 1587 34652378
Intestinal atresia 13.79 11.57 9 302957 81 34653884
Pregnancy of partner 13.79 11.57 16 302950 330 34653635
Vertigo 13.77 11.57 148 302818 25388 34628577
Pneumonia aspiration 13.74 11.57 268 302698 41635 34612330
Peripheral vascular disorder 13.73 11.57 14 302952 5022 34648943
Drug tolerance 13.65 11.57 4 302962 2878 34651087
High density lipoprotein decreased 13.64 11.57 6 302960 3354 34650611
Subdural hygroma 13.64 11.57 16 302950 334 34653631
Electrocardiogram Q waves 13.60 11.57 7 302959 38 34653927
Fungaemia 13.55 11.57 51 302915 2517 34651448
Gastrointestinal toxicity 13.52 11.57 53 302913 2666 34651299
Hepatitis C 13.49 11.57 42 302924 9788 34644177
Cerebrovascular accident 13.48 11.57 599 302367 84212 34569753
Diabetic hyperosmolar coma 13.46 11.57 18 302948 431 34653534
Prostate cancer stage I 13.40 11.57 3 302963 2586 34651379
Tear break up time decreased 13.38 11.57 5 302961 10 34653955
Secretion discharge 13.35 11.57 19 302947 5886 34648079
Pneumomediastinum 13.32 11.57 48 302918 2319 34651646
POEMS syndrome 13.32 11.57 7 302959 40 34653925
Oesophageal carcinoma 13.31 11.57 39 302927 9265 34644700
Acute lymphocytic leukaemia refractory 13.31 11.57 10 302956 115 34653850
Somnambulism 13.26 11.57 5 302961 3067 34650898
Superior sagittal sinus thrombosis 13.21 11.57 14 302952 260 34653705
Pneumonia cytomegaloviral 13.19 11.57 57 302909 2997 34650968
Epstein-Barr virus associated lymphoma 13.16 11.57 22 302944 646 34653319
Eosinophilic pneumonia 13.08 11.57 7 302959 3494 34650471
Immune reconstitution inflammatory syndrome 13.06 11.57 36 302930 8723 34645242
Personality change due to a general medical condition 13.04 11.57 7 302959 42 34653923
Meningoradiculitis 13.04 11.57 7 302959 42 34653923
Pneumonia cryptococcal 13.02 11.57 26 302940 878 34653087
Arrhythmia 13 11.57 225 302741 35583 34618382
Swelling 12.99 11.57 274 302692 42092 34611873
Retroperitoneal mass 12.93 11.57 9 302957 91 34653874
Myoglobin blood increased 12.92 11.57 5 302961 3018 34650947
Capillary leak syndrome 12.89 11.57 46 302920 2212 34651753
Corynebacterium infection 12.87 11.57 21 302945 604 34653361
Acinetobacter bacteraemia 12.87 11.57 11 302955 154 34653811
Metastases to spleen 12.85 11.57 18 302948 451 34653514
Polyp 12.84 11.57 9 302957 3883 34650082
Oesophageal irritation 12.83 11.57 8 302958 66 34653899
Blood immunoglobulin D increased 12.82 11.57 4 302962 3 34653962
Ilium fracture 12.82 11.57 11 302955 155 34653810
Lichenoid keratosis 12.80 11.57 3 302963 2505 34651460
Arachnoiditis 12.79 11.57 16 302950 358 34653607
Diabetic metabolic decompensation 12.79 11.57 39 302927 1727 34652238
VIth nerve paresis 12.78 11.57 7 302959 44 34653921
Basosquamous carcinoma of skin 12.77 11.57 5 302961 12 34653953
Blood culture positive 12.76 11.57 78 302888 4705 34649260
Tumour perforation 12.76 11.57 15 302951 314 34653651
Epstein-Barr virus infection reactivation 12.73 11.57 29 302937 1075 34652890
Disinhibition 12.73 11.57 6 302960 3220 34650745
Macular fibrosis 12.72 11.57 16 302950 360 34653605
Leukoencephalopathy 12.71 11.57 71 302895 4144 34649821
Pneumonia respiratory syncytial viral 12.65 11.57 26 302940 897 34653068
Weight increased 12.64 11.57 668 302298 92365 34561600
Bone sequestrum 12.60 11.57 20 302946 562 34653403
Diverticulum 12.58 11.57 27 302939 7132 34646833
Hypertonia 12.52 11.57 11 302955 4235 34649730
Acute myocardial infarction 12.50 11.57 362 302604 53357 34600608
Metastases to meninges 12.35 11.57 34 302932 1420 34652545
Bradyphrenia 12.34 11.57 14 302952 4784 34649181
Glomerular filtration rate decreased 12.33 11.57 64 302902 12897 34641068
Amyotrophy 12.33 11.57 18 302948 469 34653496
Hypercalcaemia of malignancy 12.31 11.57 12 302954 201 34653764
Plasma cells present 12.29 11.57 4 302962 4 34653961
Recalled product administered 12.28 11.57 19 302947 522 34653443
Pneumonia legionella 12.26 11.57 40 302926 1837 34652128
Duodenal ulcer 12.25 11.57 47 302919 10285 34643680
Mixed anxiety and depressive disorder 12.23 11.57 9 302957 100 34653865
Coccidioidomycosis 12.20 11.57 23 302943 744 34653221
Cytokine storm 12.18 11.57 22 302944 688 34653277
Retinal injury 12.17 11.57 8 302958 73 34653892
Hip deformity 12.16 11.57 9 302957 101 34653864
Acute erythroid leukaemia 12.15 11.57 11 302955 167 34653798
Renal disorder 12.15 11.57 298 302668 25182 34628783
Aspergillus test positive 12.10 11.57 18 302948 477 34653488
Chest discomfort 12.06 11.57 370 302596 54160 34599805
Transitional cell cancer of the renal pelvis and ureter 12.05 11.57 6 302960 30 34653935
Abscess fungal 12.04 11.57 13 302953 247 34653718
Dialysis 12.03 11.57 53 302913 11155 34642810
VIth nerve paralysis 12.03 11.57 24 302942 810 34653155
Peritumoural oedema 11.98 11.57 5 302961 15 34653950
Gastrointestinal wall thinning 11.98 11.57 5 302961 15 34653950
Renal injury 11.98 11.57 53 302913 11142 34642823
Maternal exposure during pregnancy 11.96 11.57 15 302951 4903 34649062
Hyperglycaemic hyperosmolar nonketotic syndrome 11.95 11.57 31 302935 1249 34652716
Idiopathic pulmonary fibrosis 11.89 11.57 8 302958 3526 34650439
Therapy responder 11.89 11.57 11 302955 172 34653793
B-cell lymphoma refractory 11.89 11.57 11 302955 172 34653793
Pneumoretroperitoneum 11.88 11.57 10 302956 137 34653828
Interstitial lung disease 11.87 11.57 454 302512 64828 34589137
Impaired driving ability 11.86 11.57 4 302962 2629 34651336
Radiation inflammation 11.82 11.57 25 302941 880 34653085
Device use error 11.81 11.57 3 302963 2372 34651593
Corneal deposits 11.80 11.57 12 302954 212 34653753
Spinal disorder 11.77 11.57 70 302896 4182 34649783
Dysuria 11.75 11.57 165 302801 26987 34626978
Injury corneal 11.75 11.57 5 302961 16 34653949
Precursor T-lymphoblastic lymphoma/leukaemia recurrent 11.75 11.57 5 302961 16 34653949
Bacteroides bacteraemia 11.75 11.57 5 302961 16 34653949
Janeway lesion 11.75 11.57 5 302961 16 34653949
Renal failure 11.73 11.57 1298 301668 129259 34524706
Nicotinic acid deficiency 11.73 11.57 9 302957 107 34653858
Alanine aminotransferase abnormal 11.72 11.57 14 302952 4674 34649291
Chest wall mass 11.65 11.57 8 302958 79 34653886
Pneumonia klebsiella 11.61 11.57 58 302908 3242 34650723

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 3858.21 10.09 2971 498056 50288 79193073
Neutropenia 2971.88 10.09 5957 495070 281753 78961608
Febrile neutropenia 2699.89 10.09 5041 495986 225958 79017403
Thrombocytopenia 2529.02 10.09 5315 495712 259944 78983417
Neuropathy peripheral 2290.11 10.09 3568 497459 137737 79105624
Pneumonia 1640.54 10.09 8326 492701 651920 78591441
Completed suicide 1338.75 10.09 46 500981 245721 78997640
Disease progression 1212.21 10.09 3198 497829 181164 79062197
Plasma cell myeloma recurrent 1087.64 10.09 561 500466 4440 79238921
Off label use 1069.56 10.09 9504 491523 897711 78345650
Platelet count decreased 956.13 10.09 3042 497985 191622 79051739
Pancytopenia 927.01 10.09 2711 498316 163034 79080327
Sepsis 839.55 10.09 3635 497392 265793 78977568
Rheumatoid arthritis 823.20 10.09 156 500871 208314 79035047
Arthralgia 781.62 10.09 1506 499521 570297 78673064
Deep vein thrombosis 752.28 10.09 2056 498971 118863 79124498
Drug abuse 709.51 10.09 92 500935 162599 79080762
Pain 664.66 10.09 2238 498789 701564 78541797
Death 653.22 10.09 5913 495114 560601 78682760
Neutrophil count decreased 641.52 10.09 1654 499373 92305 79151056
Septic shock 625.38 10.09 1944 499083 120857 79122504
Cytopenia 605.51 10.09 693 500334 19690 79223671
Plasmacytoma 591.53 10.09 360 500667 4043 79239318
Pulmonary embolism 591.22 10.09 2389 498638 169265 79074096
Neutropenic sepsis 587.72 10.09 786 500241 26278 79217083
Intentional overdose 572.57 10.09 21 501006 105939 79137422
Drug hypersensitivity 566.98 10.09 625 500402 298291 78945070
White blood cell count decreased 566.64 10.09 2515 498512 185773 79057588
Leukopenia 566.24 10.09 1815 499212 114698 79128663
Anaemia 557.02 10.09 4731 496296 440284 78803077
Mucosal inflammation 548.77 10.09 1362 499665 74218 79169143
Unevaluable event 535.01 10.09 1120 499907 54465 79188896
Joint swelling 517.77 10.09 631 500396 288015 78955346
Polyneuropathy 514.65 10.09 695 500332 23456 79219905
Synovitis 489.12 10.09 168 500859 150566 79092795
Tumour lysis syndrome 487.61 10.09 674 500353 23265 79220096
Overdose 463.98 10.09 292 500735 183914 79059447
Systemic lupus erythematosus 462.72 10.09 98 500929 121051 79122310
Injection site pain 462.43 10.09 122 500905 129716 79113645
Therapeutic product effect decreased 459.98 10.09 227 500800 163636 79079725
Arthropathy 459.70 10.09 271 500756 176840 79066521
Pyrexia 452.77 10.09 6364 494663 672345 78571016
Malignant neoplasm progression 450.96 10.09 1871 499156 134119 79109242
Contraindicated product administered 450.19 10.09 213 500814 157325 79086036
Drug interaction 416.20 10.09 1284 499743 413899 78829462
Hand deformity 409.52 10.09 78 500949 103841 79139520
Diarrhoea 407.02 10.09 7771 493256 872718 78370643
Musculoskeletal stiffness 401.51 10.09 307 500720 174701 79068660
Constipation 395.57 10.09 3087 497940 279963 78963398
Abdominal discomfort 385.60 10.09 612 500415 250115 78993246
Full blood count decreased 385.49 10.09 642 500385 26177 79217184
Therapy partial responder 374.27 10.09 503 500524 16894 79226467
Pemphigus 373.29 10.09 84 500943 99498 79143863
Pneumocystis jirovecii pneumonia 365.49 10.09 699 500328 31809 79211552
Headache 358.42 10.09 2521 498506 651251 78592110
Plasma cell leukaemia 353.16 10.09 188 500839 1598 79241763
Psoriasis 345.11 10.09 71 500956 89516 79153845
Peripheral sensory neuropathy 334.05 10.09 411 500616 12622 79230739
Bronchopulmonary aspergillosis 331.62 10.09 542 500485 21752 79221609
COVID-19 pneumonia 331.34 10.09 626 500401 28223 79215138
Thrombosis 323.88 10.09 1213 499814 82887 79160474
Suicide attempt 318.89 10.09 66 500961 82866 79160495
Anti-cyclic citrullinated peptide antibody positive 315.94 10.09 68 500959 83075 79160286
Mucormycosis 310.98 10.09 322 500705 8147 79235214
Cytokine release syndrome 310.49 10.09 694 500333 35304 79208057
Glossodynia 305.66 10.09 133 500894 103204 79140157
Myelodysplastic syndrome 303.78 10.09 621 500406 29680 79213681
Swelling 302.02 10.09 563 500464 216148 79027213
Posterior reversible encephalopathy syndrome 296.55 10.09 566 500461 25715 79217646
Bone marrow failure 294.95 10.09 846 500181 50261 79193100
Haematotoxicity 289.50 10.09 419 500608 15100 79228261
Loss of personal independence in daily activities 279 10.09 148 500879 102432 79140929
Condition aggravated 278.40 10.09 1924 499103 499200 78744161
Osteonecrosis 268.76 10.09 600 500427 30495 79212866
Drug intolerance 258.58 10.09 825 500202 263294 78980067
Injection site erythema 255.60 10.09 86 500941 78111 79165250
Endophthalmitis 249.83 10.09 252 500775 6176 79237185
Psoriatic arthropathy 249.40 10.09 89 500938 77910 79165451
Wound 246.35 10.09 220 500807 115959 79127402
Pericarditis 245.25 10.09 178 500849 104058 79139303
Stress 237.77 10.09 101 500926 79511 79163850
Arthritis 235.93 10.09 224 500803 114656 79128705
Respiratory failure 232.82 10.09 1937 499090 178974 79064387
Depression 232.46 10.09 649 500378 216141 79027220
Discomfort 227.76 10.09 272 500755 125345 79118016
Suicidal ideation 227.75 10.09 97 500930 76243 79167118
Light chain analysis increased 224.47 10.09 138 500889 1580 79241781
Pain in extremity 222.36 10.09 1360 499667 363178 78880183
Febrile bone marrow aplasia 219.15 10.09 335 500692 12685 79230676
Plasma cell myeloma refractory 217.56 10.09 99 500928 573 79242788
Rhinocerebral mucormycosis 216.65 10.09 114 500913 944 79242417
Hyperglycaemia 210.89 10.09 939 500088 69396 79173965
Haemophagocytic lymphohistiocytosis 210.04 10.09 440 500587 21397 79221964
Strongyloidiasis 209.56 10.09 183 500844 3715 79239646
Multiple organ dysfunction syndrome 209.10 10.09 1383 499644 118863 79124498
Cytomegalovirus chorioretinitis 205.67 10.09 211 500816 5279 79238082
Mobility decreased 204.47 10.09 281 500746 121894 79121467
Rheumatoid factor positive 204.13 10.09 61 500966 59778 79183583
Intentional product misuse 203.20 10.09 179 500848 94986 79148375
Inappropriate schedule of product administration 198.89 10.09 333 500694 133295 79110066
Lymphopenia 198.26 10.09 528 500499 30029 79213332
Bacteraemia 196.84 10.09 551 500476 32273 79211088
Asthma 195.26 10.09 343 500684 134752 79108609
Blood pressure fluctuation 192.94 10.09 90 500937 67055 79176306
Rhabdomyolysis 192.67 10.09 218 500809 102913 79140448
Neurotoxicity 192.20 10.09 543 500484 31975 79211386
Multiple sclerosis relapse 189.64 10.09 32 500995 46501 79196860
Hepatic enzyme increased 188.90 10.09 556 500471 182054 79061307
Weight increased 183.98 10.09 1007 500020 276379 78966982
Helicobacter infection 183.10 10.09 105 500922 69599 79173762
Treatment failure 181.52 10.09 512 500515 169974 79073387
Injection site reaction 179.48 10.09 60 500967 54725 79188636
Osteoarthritis 173.76 10.09 175 500852 87134 79156227
Injection site swelling 172.16 10.09 42 500985 47090 79196271
Squamous cell carcinoma of skin 170.51 10.09 312 500715 13721 79229640
Product use in unapproved indication 169.00 10.09 2355 498672 248004 78995357
Wrong technique in product usage process 168.81 10.09 130 500897 73745 79169616
Acute lymphocytic leukaemia recurrent 168.76 10.09 177 500850 4547 79238814
Injury 167.59 10.09 144 500883 77352 79166009
Injection site pruritus 165.99 10.09 32 500995 42251 79201110
Diffuse large B-cell lymphoma recurrent 163.63 10.09 165 500862 4042 79239319
Blood pressure increased 163.32 10.09 727 500300 210633 79032728
Flushing 163.10 10.09 1031 499996 87237 79156124
Myelosuppression 161.61 10.09 589 500438 39707 79203654
Nasopharyngitis 161.12 10.09 935 500092 252946 78990415
Injection site bruising 161.02 10.09 31 500996 40971 79202390
Intraocular pressure increased 159.40 10.09 240 500787 8965 79234396
Intentional self-injury 157.74 10.09 12 501015 32407 79210954
Anxiety 155.69 10.09 919 500108 247593 78995768
Irritable bowel syndrome 153.41 10.09 101 500926 62140 79181221
Aspergillus infection 151.51 10.09 357 500670 18804 79224557
Sinusitis 149.51 10.09 675 500352 194826 79048535
Sleep disorder due to general medical condition, insomnia type 149.29 10.09 44 500983 43512 79199849
Muscle injury 149.22 10.09 59 500968 48502 79194859
Acute lymphocytic leukaemia 147.65 10.09 169 500858 4800 79238561
Pneumonitis 145.95 10.09 762 500265 60098 79183263
Hypoglycaemia 145.84 10.09 259 500768 101335 79142026
Parainfluenzae virus infection 145.31 10.09 179 500848 5503 79237858
Fibromyalgia 144.76 10.09 115 500912 64225 79179136
Bone pain 144.24 10.09 713 500314 55029 79188332
Blood pressure systolic increased 139.41 10.09 129 500898 66857 79176504
Monoclonal immunoglobulin present 138.83 10.09 86 500941 999 79242362
Sedation 137.98 10.09 77 500950 51818 79191543
Dehydration 136.30 10.09 2254 498773 245933 78997428
Duodenal ulcer perforation 136.04 10.09 129 500898 66082 79177279
Hiccups 136.02 10.09 234 500793 9797 79233564
Large intestine perforation 134.86 10.09 289 500738 14278 79229083
Wheezing 134.28 10.09 337 500690 116327 79127034
Cytomegalovirus infection 132.89 10.09 576 500451 42068 79201293
Drug ineffective for unapproved indication 132.29 10.09 655 500372 50583 79192778
Fall 131.93 10.09 2212 498815 485417 78757944
Incorrect dose administered 131.48 10.09 173 500854 76457 79166904
Acute myeloid leukaemia 131.16 10.09 460 500567 30425 79212936
Cytomegalovirus infection reactivation 131.10 10.09 213 500814 8503 79234858
COVID-19 128.60 10.09 1536 499491 156138 79087223
Coma 128.50 10.09 275 500752 100374 79142987
Osteolysis 126.99 10.09 149 500878 4349 79239012
Therapeutic product effect incomplete 126.56 10.09 460 500567 141185 79102176
Anaphylactic shock 125.31 10.09 503 500524 35493 79207868
Metastases to central nervous system 125.05 10.09 301 500726 16074 79227287
Systemic candida 124.99 10.09 181 500846 6525 79236836
Osteonecrosis of jaw 122.77 10.09 568 500459 42658 79200703
Hospitalisation 122.39 10.09 255 500772 93981 79149380
Neoplasm progression 121.80 10.09 644 500383 51038 79192323
Atrial fibrillation 121.41 10.09 1831 499196 196055 79047306
Knee arthroplasty 119.64 10.09 61 500966 43187 79200174
Clostridium difficile colitis 117.94 10.09 458 500569 31825 79211536
Candida infection 117.42 10.09 514 500513 37700 79205661
Hypoxia 117.40 10.09 1076 499951 102167 79141194
Malaise 117.08 10.09 2271 498756 487598 78755763
Alopecia 116.75 10.09 912 500115 230443 79012918
Impaired healing 116.54 10.09 234 500793 87421 79155940
Migraine 115.96 10.09 234 500793 87259 79156102
Product dose omission issue 115.70 10.09 996 500031 246541 78996820
Colitis ulcerative 115.64 10.09 37 500990 34705 79208656
Drug withdrawal syndrome 115.52 10.09 37 500990 34681 79208680
Corneal oedema 115.41 10.09 110 500917 2510 79240851
Abortion spontaneous 114.42 10.09 23 501004 29484 79213877
Coronary artery disease 114.20 10.09 146 500881 65328 79178033
Blister 114.16 10.09 377 500650 119099 79124262
Somnolence 113.30 10.09 958 500069 238023 79005338
Pathological fracture 112.84 10.09 222 500805 10315 79233046
Hypofibrinogenaemia 111.69 10.09 96 500931 1906 79241455
Drug ineffective 110.68 10.09 5610 495417 1075303 78168058
Neuroleptic malignant syndrome 110.01 10.09 20 501007 27539 79215822
Venoocclusive liver disease 109.51 10.09 234 500793 11537 79231824
Myalgia 108.68 10.09 701 500326 184940 79058421
Blood cholesterol increased 107.49 10.09 228 500799 83492 79159869
Asthenia 107.44 10.09 4078 496949 507611 78735750
Secondary immunodeficiency 106.40 10.09 116 500911 3118 79240243
Lactic acidosis 104.97 10.09 175 500852 70184 79173177
Palpitations 102.95 10.09 427 500600 126183 79117178
Red blood cell sedimentation rate increased 102.24 10.09 83 500944 45859 79197502
Myocardial infarction 101.91 10.09 707 500320 183422 79059939
Therapy non-responder 100.92 10.09 954 500073 91351 79152010
Sopor 99.96 10.09 41 500986 32969 79210392
Blood creatine phosphokinase increased 99.88 10.09 163 500864 65927 79177434
Hypercalcaemia 99.72 10.09 492 500535 37938 79205423
C-reactive protein abnormal 99.63 10.09 94 500933 48273 79195088
Respiratory tract infection 99.61 10.09 584 500443 48105 79195256
Poisoning 99.46 10.09 19 501008 25253 79218108
Embolism 99.34 10.09 250 500777 13732 79229629
Diffuse large B-cell lymphoma refractory 99.32 10.09 78 500949 1357 79242004
Surgery 98.73 10.09 41 500986 32725 79210636
Sleep apnoea syndrome 98.61 10.09 53 500974 36425 79206936
Contusion 98.60 10.09 540 500487 148236 79095125
Product prescribing error 98.44 10.09 82 500945 44731 79198630
Gait disturbance 98.26 10.09 832 500195 206674 79036687
Febrile infection 98.07 10.09 113 500914 3233 79240128
Dizziness 97.48 10.09 2540 498487 523901 78719460
Hypertriglyceridaemia 96.02 10.09 233 500794 12507 79230854
Injection site haemorrhage 95.80 10.09 28 500999 27842 79215519
Myelopathy 95.16 10.09 131 500896 4502 79238859
Nasal congestion 94.55 10.09 213 500814 76339 79167022
Rhinovirus infection 94.33 10.09 175 500852 7778 79235583
International normalised ratio increased 94.20 10.09 249 500778 84472 79158889
Pneumonia influenzal 93.53 10.09 103 500924 2801 79240560
Gastrooesophageal reflux disease 93.47 10.09 338 500689 103908 79139453
Red blood cell sedimentation rate abnormal 93.41 10.09 11 501016 20952 79222409
Folliculitis 93.00 10.09 127 500900 55253 79188108
Hepatitis B reactivation 92.87 10.09 150 500877 5958 79237403
Hypogammaglobulinaemia 92.47 10.09 232 500795 12719 79230642
Device issue 91.79 10.09 28 500999 27080 79216281
Pruritus 91.66 10.09 1838 499189 392810 78850551
Pneumonia fungal 90.96 10.09 211 500816 10999 79232362
Peripheral motor neuropathy 90.87 10.09 109 500918 3258 79240103
Maternal exposure during pregnancy 90.80 10.09 495 500532 136043 79107318
Spinal cord compression 90.75 10.09 152 500875 6225 79237136
Serotonin syndrome 89.86 10.09 90 500937 44937 79198424
Cardiac amyloidosis 88.26 10.09 81 500946 1759 79241602
Fatigue 88.23 10.09 6879 494148 922848 78320513
Colitis 87.93 10.09 773 500254 72534 79170827
Osteoporosis 86.99 10.09 128 500899 53984 79189377
Heart rate decreased 86.56 10.09 196 500831 70120 79173241
Obesity 86.55 10.09 57 500970 35068 79208293
Aplasia 86.47 10.09 167 500860 7653 79235708
Amyloidosis 85.46 10.09 95 500932 2611 79240750
Substance-induced psychotic disorder 85.44 10.09 106 500921 3283 79240078
B precursor type acute leukaemia 84.48 10.09 45 500982 383 79242978
Hip arthroplasty 84.15 10.09 61 500966 35695 79207666
Immune effector cell-associated neurotoxicity syndrome 84.03 10.09 140 500887 5708 79237653
Neutropenic colitis 83.85 10.09 138 500889 5569 79237792
Staphylococcal bacteraemia 83.21 10.09 215 500812 12003 79231358
Foot deformity 83.09 10.09 24 501003 24050 79219311
Pneumonia bacterial 83.01 10.09 289 500738 19042 79224319
Labelled drug-drug interaction medication error 82.67 10.09 35 500992 27615 79215746
Pseudomonal sepsis 82.37 10.09 143 500884 6031 79237330
Laboratory test abnormal 82.20 10.09 372 500655 27676 79215685
Pulmonary mucormycosis 82.10 10.09 64 500963 1101 79242260
Sleep disorder 82.07 10.09 270 500757 85407 79157954
Joint range of motion decreased 82.02 10.09 54 500973 33228 79210133
Accidental overdose 81.44 10.09 77 500950 39504 79203857
Type 2 diabetes mellitus 80.73 10.09 147 500880 56975 79186386
Eastern Cooperative Oncology Group performance status worsened 80.33 10.09 81 500946 1984 79241377
Musculoskeletal pain 80.25 10.09 350 500677 102004 79141357
Renal failure 80.20 10.09 1738 499289 199230 79044131
Injection site warmth 79.74 10.09 3 501024 14804 79228557
Accidental exposure to product 79.69 10.09 49 500978 31273 79212088
Blood pressure diastolic abnormal 78.69 10.09 13 501014 19189 79224172
Frequent bowel movements 78.28 10.09 44 500983 29495 79213866
Tenosynovitis 77.87 10.09 5 501022 15549 79227812
Blood pressure diastolic decreased 77.25 10.09 47 500980 30169 79213192
Choroiditis 76.60 10.09 66 500961 1315 79242046
Joint stiffness 76.57 10.09 86 500941 40744 79202617
Eczema 76.52 10.09 86 500941 40732 79202629
Medication error 74.61 10.09 204 500823 68438 79174923
Therapeutic response shortened 74.08 10.09 7 501020 15856 79227505
Hepatic cirrhosis 74.08 10.09 66 500961 34840 79208521
Bacterial sepsis 74.01 10.09 161 500866 8037 79235324
Feeling abnormal 73.70 10.09 642 500385 158557 79084804
Injection site mass 73.68 10.09 18 501009 20166 79223195
Escherichia bacteraemia 73.62 10.09 141 500886 6421 79236940
Hallucination 73.61 10.09 283 500744 85462 79157899
Electrocardiogram QT prolonged 73.37 10.09 305 500722 90081 79153280
Bacterial infection 73.16 10.09 389 500638 30891 79212470
Bone lesion 72.42 10.09 132 500895 5787 79237574
Blood lactate dehydrogenase increased 72.00 10.09 457 500570 38713 79204648
Respiratory arrest 71.99 10.09 159 500868 57391 79185970
Acute respiratory distress syndrome 70.69 10.09 497 500530 43570 79199791
Primary amyloidosis 70.40 10.09 29 500998 126 79243235
Hypokalaemia 70.29 10.09 1284 499743 142756 79100605
Treatment noncompliance 69.93 10.09 139 500888 52129 79191232
Product quality issue 69.86 10.09 66 500961 33874 79209487
Peripheral swelling 69.55 10.09 1233 499794 268384 78974977
Pseudomonas infection 69.50 10.09 288 500739 20615 79222746
Disseminated aspergillosis 69.37 10.09 57 500970 1061 79242300
Adrenal insufficiency 69.20 10.09 358 500669 28129 79215232
Bone erosion 69.01 10.09 14 501013 17833 79225528
Aggression 68.62 10.09 135 500892 50823 79192538
Pulmonary arterial hypertension 68.59 10.09 47 500980 28319 79215042
Sleep disorder due to a general medical condition 67.48 10.09 6 501021 14271 79229090
Hypertransaminasaemia 67.43 10.09 196 500831 11728 79231633
Impaired work ability 67.23 10.09 20 501007 19661 79223700
Glycosylated haemoglobin increased 66.84 10.09 19 501008 19241 79224120
Ill-defined disorder 66.32 10.09 203 500824 65672 79177689
Microsporidia infection 65.77 10.09 52 500975 914 79242447
Decreased appetite 65.42 10.09 2702 498325 339716 78903645
Obstructive airways disorder 64.96 10.09 61 500966 31398 79211963
Disseminated cryptococcosis 64.24 10.09 68 500959 1766 79241595
Autonomic neuropathy 64.15 10.09 69 500958 1826 79241535
Diverticular perforation 64.12 10.09 125 500902 5768 79237593
JC virus infection 64.11 10.09 99 500928 3782 79239579
Ankylosing spondylitis 63.97 10.09 3 501024 12202 79231159
Prescribed overdose 63.48 10.09 87 500940 37796 79205565
Depressed level of consciousness 63.37 10.09 352 500675 96300 79147061
Adenocarcinoma of colon 63.32 10.09 120 500907 5421 79237940
Drug dependence 63.06 10.09 99 500928 40670 79202691
Crying 62.99 10.09 33 500994 23010 79220351
Aplastic anaemia 62.95 10.09 251 500776 17654 79225707
Muscle spasticity 62.91 10.09 28 500999 21447 79221914
Pneumonia pneumococcal 62.55 10.09 100 500927 3937 79239424
Brain oedema 62.42 10.09 319 500708 24944 79218417
Hyperviscosity syndrome 62.30 10.09 37 500990 396 79242965
Parkinsonism 62.10 10.09 14 501013 16570 79226791
Nephrolithiasis 62.03 10.09 153 500874 53138 79190223
Peripheral sensorimotor neuropathy 61.66 10.09 85 500942 2925 79240436
Escherichia sepsis 61.36 10.09 153 500874 8355 79235006
Visceral leishmaniasis 60.93 10.09 53 500974 1070 79242291
Malignant neoplasm of unknown primary site 60.72 10.09 45 500982 715 79242646
Influenza like illness 60.69 10.09 238 500789 71469 79171892
Refractory cytopenia with multilineage dysplasia 60.66 10.09 31 500996 240 79243121
Inflammation 60.62 10.09 343 500684 93410 79149951
Disseminated intravascular coagulation 60.30 10.09 409 500618 35433 79207928
Panic attack 60.07 10.09 39 500988 24177 79219184
Ageusia 59.96 10.09 235 500792 16397 79226964
Blood pressure systolic abnormal 59.88 10.09 17 501010 17230 79226131
Pleural effusion 59.78 10.09 1262 499765 144000 79099361
Staphylococcal sepsis 59.67 10.09 216 500811 14510 79228851
Hypocalcaemia 59.64 10.09 526 500501 49398 79193963
Progressive multifocal leukoencephalopathy 59.46 10.09 272 500755 20328 79223033
B-cell type acute leukaemia 59.43 10.09 39 500988 504 79242857
Urticaria 59.23 10.09 813 500214 184388 79058973
Infective pulmonary exacerbation of cystic fibrosis 59.15 10.09 6 501021 12845 79230516
Hyperkalaemia 59.05 10.09 448 500579 113950 79129411
Nervous system disorder 58.78 10.09 328 500699 26528 79216833
Intestinal perforation 58.65 10.09 241 500786 17185 79226176
Device malfunction 58.21 10.09 31 500996 21417 79221944
Bronchospasm 58.04 10.09 309 500718 24550 79218811
Fear 57.90 10.09 33 500994 21953 79221408
Thymus hypoplasia 57.03 10.09 48 500979 925 79242436
Nocardiosis 56.45 10.09 116 500911 5563 79237798
Road traffic accident 55.97 10.09 119 500908 43545 79199816
Coeliac disease 55.80 10.09 4 501023 11347 79232014
Premature delivery 55.68 10.09 293 500734 23174 79220187
Pregnancy 55.52 10.09 52 500975 26799 79216562
Sedation complication 55.23 10.09 15 501012 15654 79227707
Hypercholesterolaemia 54.87 10.09 39 500988 23056 79220305
Product complaint 54.79 10.09 9 501018 13340 79230021
Cryptococcosis 54.78 10.09 87 500940 3406 79239955
Infection reactivation 54.38 10.09 75 500952 2582 79240779
Tendonitis 54.35 10.09 42 500985 23788 79219573
Haematochezia 54.34 10.09 325 500702 87320 79156041
Injection site urticaria 54.11 10.09 8 501019 12818 79230543
Pulmonary thrombosis 54.04 10.09 184 500843 11987 79231374
Oral candidiasis 54.04 10.09 345 500682 29283 79214078
Multiple sclerosis 53.77 10.09 37 500990 22245 79221116
Respiratory distress 53.68 10.09 582 500445 57757 79185604
Carpal tunnel syndrome 53.33 10.09 28 500999 19500 79223861
Lupus-like syndrome 53.31 10.09 11 501016 13846 79229515
Lymphoid tissue hypoplasia 52.71 10.09 45 500982 885 79242476
Human bocavirus infection 52.66 10.09 41 500986 704 79242657
Ocular hypertension 52.61 10.09 56 500971 1464 79241897
Klebsiella infection 52.59 10.09 217 500810 15503 79227858
Exostosis 52.59 10.09 20 501007 16838 79226523
Meningitis cryptococcal 51.81 10.09 85 500942 3421 79239940
Eosinophilia 51.37 10.09 132 500895 45213 79198148
Herpes simplex encephalitis 50.93 10.09 40 500987 696 79242665
Underdose 50.80 10.09 81 500946 33070 79210291
Second primary malignancy 50.32 10.09 201 500826 14149 79229212
Corneal decompensation 50.29 10.09 18 501009 48 79243313
Injection site rash 50.14 10.09 25 501002 17929 79225432
Nightmare 50.12 10.09 53 500974 25808 79217553
Ear infection 50.10 10.09 87 500940 34345 79209016
Hydrocephalus 50.05 10.09 146 500881 8754 79234607
Illness 49.96 10.09 139 500888 46372 79196989
Injection site induration 49.63 10.09 3 501024 9816 79233545
Poor venous access 49.60 10.09 26 501001 18123 79225238
Hiatus hernia 49.56 10.09 44 500983 23268 79220093
Product storage error 49.38 10.09 20 501007 16206 79227155
Escherichia infection 49.14 10.09 234 500793 17783 79225578
Respiratory syncytial virus infection 48.86 10.09 150 500877 9252 79234109
Pneumonia cytomegaloviral 48.81 10.09 101 500926 4868 79238493
Dysgeusia 48.78 10.09 562 500465 56615 79186746
Neck pain 48.71 10.09 276 500751 75141 79168220
Dyskinesia 48.70 10.09 133 500894 44640 79198721
Glioblastoma 48.55 10.09 56 500971 1604 79241757
Tardive dyskinesia 48.49 10.09 5 501022 10566 79232795
Device related infection 48.29 10.09 375 500652 33919 79209442
Venous thrombosis 48.23 10.09 125 500902 6991 79236370
Lip swelling 47.97 10.09 117 500910 40794 79202567
Thrombotic microangiopathy 47.97 10.09 252 500775 19917 79223444
Refractory anaemia with an excess of blasts 47.63 10.09 42 500985 864 79242497
Enterococcal infection 47.62 10.09 210 500817 15450 79227911
Computerised tomogram thorax abnormal 47.60 10.09 67 500960 2352 79241009
Enterobacter infection 47.50 10.09 95 500932 4467 79238894
Joint effusion 47.49 10.09 27 501000 17987 79225374
Enthesopathy 47.26 10.09 8 501019 11600 79231761
Brain stem glioma 47.16 10.09 24 501003 184 79243177
Ileus 47.06 10.09 304 500723 25907 79217454
Product administration error 46.76 10.09 80 500947 31766 79211595
Respiratory depression 46.75 10.09 63 500964 27567 79215794
Leukoencephalopathy 46.45 10.09 132 500895 7797 79235564
Hallucination, visual 46.45 10.09 84 500943 32645 79210716
Breast cancer female 46.43 10.09 8 501019 11453 79231908
Performance status decreased 46.28 10.09 112 500915 6001 79237360
Angioedema 46.06 10.09 284 500743 75751 79167610
Necrotising fasciitis 45.97 10.09 111 500916 5939 79237422
Cardiac murmur 45.78 10.09 21 501006 15803 79227558
Substance abuse 45.74 10.09 6 501021 10520 79232841
Rectal adenocarcinoma 45.30 10.09 51 500976 1422 79241939
Listeriosis 45.28 10.09 63 500964 2187 79241174
Panniculitis 45.22 10.09 11 501016 12360 79231001
Minimal residual disease 45.02 10.09 32 500995 475 79242886
Anaphylactic reaction 44.95 10.09 758 500269 82985 79160376
Ulcerative keratitis 44.79 10.09 82 500945 3607 79239754
Vasogenic cerebral oedema 44.74 10.09 51 500976 1442 79241919
Visual acuity reduced 44.74 10.09 328 500699 29141 79214220
Disability 44.65 10.09 26 501001 17094 79226267
Neutropenic infection 44.49 10.09 65 500962 2362 79240999
Disease recurrence 44.34 10.09 448 500579 43661 79199700
Anhedonia 44.31 10.09 19 501008 14879 79228482
Herpes simplex reactivation 44.31 10.09 31 500996 448 79242913
Encephalitis 44.18 10.09 197 500830 14563 79228798
Allergy test negative 44.07 10.09 27 501000 307 79243054
Miosis 44.07 10.09 22 501005 15767 79227594
Disseminated mucormycosis 44.05 10.09 37 500990 711 79242650
Bursitis 44.04 10.09 100 500927 35744 79207617
Gastrointestinal perforation 43.88 10.09 110 500917 6027 79237334
Meningitis pneumococcal 43.79 10.09 31 500996 457 79242904
Depressed mood 43.57 10.09 157 500870 48323 79195038
Meningitis listeria 43.55 10.09 43 500984 1026 79242335
Product substitution issue 43.34 10.09 38 500989 20218 79223143
Hyperbilirubinaemia 43.18 10.09 283 500744 24235 79219126
Pulmonary sepsis 43.17 10.09 81 500946 3631 79239730
Memory impairment 43.09 10.09 471 500556 111263 79132098
Bone density decreased 43.05 10.09 15 501012 13332 79230029
Pneumatosis intestinalis 42.98 10.09 112 500915 6285 79237076
Pneumonia viral 42.92 10.09 141 500886 9017 79234344
Enterocolitis 42.92 10.09 193 500834 14319 79229042
Cytomegalovirus viraemia 42.90 10.09 177 500850 12644 79230717
Exposure to toxic agent 42.88 10.09 4 501023 9154 79234207
Foot fracture 42.65 10.09 45 500982 21936 79221425
Pneumomediastinum 42.63 10.09 80 500947 3587 79239774
Akathisia 42.59 10.09 15 501012 13244 79230117
Arachnoiditis 42.58 10.09 37 500990 746 79242615
Gastrointestinal disorder 42.53 10.09 527 500500 121678 79121683
Mantle cell lymphoma recurrent 42.12 10.09 33 500994 572 79242789
Gastric perforation 41.96 10.09 84 500943 3953 79239408
Gastric disorder 41.61 10.09 110 500917 37323 79206038
Loss of consciousness 41.40 10.09 774 500253 167169 79076192
Non-small cell lung cancer 41.35 10.09 110 500917 6250 79237111
Computerised tomogram thorax 41.34 10.09 29 500998 421 79242940
Burning sensation 40.95 10.09 209 500818 58423 79184938
Drug level increased 40.76 10.09 121 500906 39530 79203831
Procedural pain 40.74 10.09 51 500976 23033 79220328
Chronic obstructive pulmonary disease 40.62 10.09 342 500685 85077 79158284
Blood culture positive 40.61 10.09 131 500896 8298 79235063
Hallucination, auditory 40.56 10.09 42 500985 20651 79222710
Pseudomonas test positive 40.52 10.09 54 500973 1798 79241563
Metastatic malignant melanoma 40.42 10.09 68 500959 2795 79240566
Atypical pneumonia 40.37 10.09 112 500915 6524 79236837
Hyperaemia 40.15 10.09 71 500956 3039 79240322
Extrapyramidal disorder 40.14 10.09 50 500977 22629 79220732
Iron deficiency anaemia 40.03 10.09 62 500965 25610 79217751
Withdrawal syndrome 39.85 10.09 67 500960 26787 79216574
Paraplegia 39.79 10.09 94 500933 4959 79238402
Keratitis fungal 39.74 10.09 25 501002 299 79243062
Mycobacterium chelonae infection 39.66 10.09 62 500965 2394 79240967
Venous thrombosis limb 39.63 10.09 87 500940 4370 79238991
Cholecystectomy 39.52 10.09 6 501021 9426 79233935
Guillain-Barre syndrome 39.34 10.09 135 500892 8830 79234531
Dry mouth 38.94 10.09 359 500668 87660 79155701
Atrial flutter 38.94 10.09 251 500776 21374 79221987
Emotional distress 38.94 10.09 125 500902 39844 79203517
Rheumatic fever 38.90 10.09 75 500952 28450 79214911
Meningitis bacterial 38.72 10.09 65 500962 2667 79240694
Varicella zoster virus infection 38.71 10.09 86 500941 4355 79239006
Streptococcal bacteraemia 38.64 10.09 76 500951 3530 79239831
Colitis microscopic 38.54 10.09 10 501017 10758 79232603
Hypertension 38.34 10.09 1694 499333 329298 78914063
Right ventricular failure 38.33 10.09 55 500972 23442 79219919
Enterococcal bacteraemia 38.27 10.09 69 500958 2999 79240362
Pseudomyopia 38.14 10.09 17 501010 93 79243268
Coombs indirect test positive 37.97 10.09 15 501012 57 79243304
Cardiotoxicity 37.88 10.09 165 500862 12074 79231287
Pemphigoid 37.53 10.09 25 501002 15290 79228071
Coronary artery occlusion 37.53 10.09 25 501002 15290 79228071
Transplant rejection 37.48 10.09 40 500987 19397 79223964
Atypical haemolytic uraemic syndrome 37.46 10.09 39 500988 993 79242368
Drug level decreased 37.38 10.09 22 501005 14380 79228981
Disturbance in attention 37.25 10.09 178 500849 50623 79192738
Cholelithiasis 37.19 10.09 187 500840 52477 79190884
Neoplasm recurrence 37.18 10.09 82 500945 4132 79239229
Device leakage 37.14 10.09 11 501016 10845 79232516
Haematoma 37.05 10.09 185 500842 52010 79191351
Brain abscess 36.90 10.09 90 500937 4846 79238515
Enteritis 36.63 10.09 185 500842 14398 79228963
Fusarium infection 36.43 10.09 51 500976 1781 79241580
Sensitivity to weather change 36.41 10.09 4 501023 8043 79235318
Aeromonas infection 36.34 10.09 25 501002 351 79243010
Blood fibrinogen decreased 36.28 10.09 53 500974 1926 79241435
Chest pain 36.24 10.09 1428 499599 280876 78962485
Body temperature decreased 36.09 10.09 94 500933 32051 79211310
Stem cell transplant 36.04 10.09 75 500952 3629 79239732
Haemoglobin decreased 36.04 10.09 1724 499303 220395 79022966
Metapneumovirus infection 35.98 10.09 50 500977 1734 79241627
Impaired quality of life 35.91 10.09 23 501004 14363 79228998
Cerebral toxoplasmosis 35.90 10.09 58 500969 2304 79241057
Fungaemia 35.71 10.09 85 500942 4506 79238855
Pulmonary fibrosis 35.70 10.09 149 500878 43963 79199398
Sickle cell anaemia with crisis 35.69 10.09 4 501023 7918 79235443
Klebsiella bacteraemia 35.41 10.09 66 500961 2944 79240417
Drug tolerance 35.27 10.09 6 501021 8669 79234692
Electrocardiogram QRS complex prolonged 35.24 10.09 12 501015 10821 79232540
Food allergy 35.19 10.09 12 501015 10812 79232549
Movement disorder 35.18 10.09 74 500953 27185 79216176
Enterocolitis infectious 35.12 10.09 64 500963 2805 79240556
Protein total increased 35.01 10.09 75 500952 3704 79239657
Chalazion 35.00 10.09 28 500999 501 79242860
Radiation skin injury 34.79 10.09 44 500983 1390 79241971
Sexual dysfunction 34.77 10.09 4 501023 7759 79235602
Dermatitis atopic 34.75 10.09 10 501017 10046 79233315
Necrotising retinitis 34.74 10.09 41 500986 1204 79242157
Immunosuppression 34.71 10.09 166 500861 12637 79230724
Coombs positive haemolytic anaemia 34.54 10.09 39 500988 1091 79242270
Cushingoid 34.46 10.09 135 500892 9417 79233944
Taste disorder 34.46 10.09 193 500834 15630 79227731
Polyp 34.33 10.09 5 501022 8102 79235259
Deformity 34.22 10.09 9 501018 9596 79233765
Phrenic nerve paralysis 33.73 10.09 23 501004 318 79243043
Central nervous system leukaemia 33.54 10.09 25 501002 401 79242960
Sputum discoloured 33.43 10.09 53 500974 21690 79221671
Cystitis haemorrhagic 33.39 10.09 130 500897 9042 79234319
Ovarian cyst 33.32 10.09 19 501008 12636 79230725
Neurological decompensation 33.29 10.09 90 500937 5163 79238198
Spinal operation 33.26 10.09 5 501022 7912 79235449
H1N1 influenza 33.16 10.09 58 500969 2461 79240900
Weight decreased 33.15 10.09 1859 499168 353339 78890022
Jugular vein thrombosis 33.14 10.09 82 500945 4456 79238905
Differentiation syndrome 33.07 10.09 58 500969 2466 79240895
Muscle rigidity 32.97 10.09 46 500981 19836 79223525
Joint injury 32.66 10.09 95 500932 31240 79212121
Recall phenomenon 32.66 10.09 38 500989 1099 79242262
Pneumonia escherichia 32.65 10.09 34 500993 866 79242495
Light chain analysis abnormal 32.58 10.09 19 501008 196 79243165
Bradyphrenia 32.57 10.09 13 501014 10627 79232734
Amnesia 32.50 10.09 247 500780 62810 79180551
Product monitoring error 32.40 10.09 8 501019 8898 79234463
Cellulitis orbital 32.29 10.09 32 500995 767 79242594
Urosepsis 32.08 10.09 280 500747 26215 79217146
Pneumothorax 32.08 10.09 295 500732 28028 79215333
Disseminated strongyloidiasis 31.95 10.09 20 501007 237 79243124
Angina unstable 31.88 10.09 34 500993 16493 79226868
Spinal compression fracture 31.88 10.09 199 500828 16759 79226602
Ulcer 31.88 10.09 90 500937 29882 79213479
Fungal oesophagitis 31.74 10.09 35 500992 953 79242408
Blood glucose decreased 31.57 10.09 74 500953 26160 79217201
Heavy menstrual bleeding 31.56 10.09 25 501002 13986 79229375
Neutrophil count abnormal 31.55 10.09 69 500958 3457 79239904
Immunosuppressant drug level increased 31.15 10.09 9 501018 9018 79234343
Device breakage 31.14 10.09 14 501013 10661 79232700
Paraproteinaemia 31.12 10.09 24 501003 406 79242955
Erysipelas 31.12 10.09 143 500884 10707 79232654
Hypothyroidism 31.06 10.09 197 500830 52195 79191166
Eosinophil count increased 31.02 10.09 37 500990 17068 79226293
Mitochondrial DNA mutation 30.98 10.09 24 501003 409 79242952
Infection 30.97 10.09 1835 499192 239877 79003484
Device adhesion issue 30.82 10.09 4 501023 7071 79236290
Finger deformity 30.76 10.09 5 501022 7469 79235892
Malignant transformation 30.55 10.09 38 500989 1180 79242181
Therapy interrupted 30.54 10.09 98 500929 31243 79212118
Gastrointestinal protozoal infection 30.49 10.09 14 501013 83 79243278
Diffuse large B-cell lymphoma 30.43 10.09 154 500873 11995 79231366
Sternal fracture 30.42 10.09 56 500971 2474 79240887
Bronchiectasis 30.40 10.09 59 500968 22327 79221034
Bone marrow infiltration 30.38 10.09 30 500997 716 79242645
Chills 30.22 10.09 1263 499764 158971 79084390
Ureteric compression 30.18 10.09 20 501007 263 79243098
Intervertebral disc degeneration 29.87 10.09 33 500994 15752 79227609
Capillary leak syndrome 29.81 10.09 72 500955 3853 79239508
Crossmatch incompatible 29.80 10.09 11 501016 33 79243328
Torsade de pointes 29.77 10.09 47 500980 19265 79224096
Abdominal pain upper 29.62 10.09 1128 499899 222691 79020670
Erectile dysfunction 29.62 10.09 29 500998 14635 79228726
Skin striae 29.57 10.09 47 500980 1841 79241520
Steroid diabetes 29.56 10.09 67 500960 3439 79239922
Hyperlipidaemia 29.52 10.09 76 500951 26017 79217344
Pseudomonal bacteraemia 29.52 10.09 62 500965 3020 79240341
Hypoalbuminaemia 29.50 10.09 232 500795 21065 79222296
Grip strength decreased 29.39 10.09 58 500969 21811 79221550
Dysentery 29.35 10.09 37 500990 1165 79242196
Clostridium difficile infection 29.33 10.09 403 500624 42282 79201079
Stridor 29.28 10.09 88 500939 5365 79237996
Central nervous system vasculitis 29.20 10.09 40 500987 1368 79241993
Propofol infusion syndrome 29.20 10.09 48 500979 1935 79241426
Anger 29.17 10.09 39 500988 17123 79226238
Corneal opacity 29.15 10.09 34 500993 986 79242375
Faeces discoloured 29.14 10.09 90 500937 29037 79214324
Cataract subcapsular 29.09 10.09 33 500994 928 79242433
Hypersensitivity 28.95 10.09 1349 499678 260890 78982471
Swollen joint count increased 28.95 10.09 63 500964 22864 79220497
Peritonitis 28.78 10.09 286 500741 27750 79215611
Vascular pain 28.69 10.09 32 500995 883 79242478
Breast cancer stage I 28.68 10.09 4 501023 6696 79236665
Drug dose omission by device 28.55 10.09 3 501024 6247 79237114
Platelet count abnormal 28.54 10.09 81 500946 4781 79238580
Pneumonia klebsiella 28.51 10.09 83 500944 4971 79238390
Tuberculoma of central nervous system 28.47 10.09 26 501001 561 79242800
Lymphocyte count decreased 28.35 10.09 436 500591 46853 79196508
Clostridium bacteraemia 28.34 10.09 22 501005 376 79242985
Pneumonia parainfluenzae viral 28.30 10.09 20 501007 294 79243067
Sinus congestion 28.29 10.09 51 500976 19845 79223516
Negative pressure pulmonary oedema 28.28 10.09 18 501009 220 79243141
Cerebral venous thrombosis 28.27 10.09 57 500970 2696 79240665
Ecthyma 28.22 10.09 29 500998 727 79242634
Lung infiltration 28.19 10.09 243 500784 22669 79220692
Alpha haemolytic streptococcal infection 28.08 10.09 52 500975 2308 79241053
Musculoskeletal discomfort 28.06 10.09 51 500976 19784 79223577
B-cell lymphoma recurrent 28.02 10.09 33 500994 967 79242394
Leukaemia recurrent 27.97 10.09 57 500970 2717 79240644
Melaena 27.96 10.09 246 500781 60644 79182717
Familial periodic paralysis 27.94 10.09 16 501011 159 79243202
Blood thyroid stimulating hormone increased 27.90 10.09 13 501014 9695 79233666
Cystitis bacterial 27.89 10.09 28 500999 682 79242679
Viral haemorrhagic cystitis 27.84 10.09 48 500979 2013 79241348
Meningoencephalitis herpetic 27.76 10.09 47 500980 1942 79241419
Salivary hypersecretion 27.73 10.09 29 500998 14195 79229166
Alanine aminotransferase increased 27.68 10.09 1268 499759 161302 79082059
Norovirus test positive 27.66 10.09 27 501000 635 79242726
Hypopyon 27.64 10.09 35 500992 1107 79242254
Coronary artery bypass 27.46 10.09 3 501024 6059 79237302
Joint dislocation 27.29 10.09 40 500987 16899 79226462
Acne 27.21 10.09 84 500943 27106 79216255
Drug abuser 27.18 10.09 3 501024 6010 79237351
Productive cough 27.07 10.09 391 500636 87940 79155421
Abnormal behaviour 27.06 10.09 127 500900 36294 79207067
Product dispensing error 27.05 10.09 26 501001 13237 79230124
Pulmonary hypertension 26.88 10.09 184 500843 47896 79195465
Antipsychotic drug level increased 26.86 10.09 3 501024 5954 79237407
Nodule 26.77 10.09 66 500961 22928 79220433
Liver injury 26.76 10.09 227 500800 56387 79186974
Cardio-respiratory arrest 26.76 10.09 500 500527 108010 79135351
Hypothermia 26.71 10.09 65 500962 22681 79220680
Human chorionic gonadotropin increased 26.64 10.09 35 500992 1149 79242212
Cancer pain 26.63 10.09 83 500944 5162 79238199
Device use error 26.58 10.09 6 501021 7095 79236266
Angina pectoris 26.49 10.09 203 500824 51529 79191832
Keratopathy 26.41 10.09 35 500992 1159 79242202
Restless legs syndrome 26.39 10.09 54 500973 20038 79223323
Alopecia areata 26.32 10.09 44 500983 1799 79241562
Pasteurella infection 26.31 10.09 11 501016 50 79243311
Back pain 26.27 10.09 2236 498791 301944 78941417
Temperature regulation disorder 26.26 10.09 3 501024 5850 79237511
Exposure during pregnancy 26.20 10.09 462 500565 100670 79142691
Perineal necrosis 26.10 10.09 14 501013 121 79243240
Bladder cancer 26.05 10.09 52 500975 19474 79223887
Oroantral fistula 26.05 10.09 21 501006 380 79242981
Unintentional medical device removal 26.05 10.09 8 501019 7704 79235657
Dystonia 26.04 10.09 60 500967 21339 79222022
Acute respiratory failure 26.03 10.09 522 500505 59019 79184342
Cell-mediated immune deficiency 26.00 10.09 14 501013 122 79243239
Cellulitis 25.92 10.09 882 500145 108178 79135183
Shock 25.91 10.09 401 500626 43147 79200214
Laryngospasm 25.86 10.09 69 500958 3928 79239433
Large intestine polyp 25.82 10.09 25 501002 12683 79230678
Meningitis 25.81 10.09 124 500903 9458 79233903
Basal cell carcinoma 25.73 10.09 353 500674 37022 79206339
Heart rate increased 25.68 10.09 570 500457 120154 79123207
Arteriosclerosis 25.67 10.09 47 500980 18180 79225181
Ejection fraction decreased 25.64 10.09 331 500696 34246 79209115
Foot operation 25.57 10.09 3 501024 5730 79237631
Blood loss anaemia 25.56 10.09 36 500991 15462 79227899
Catheterisation cardiac 25.54 10.09 3 501024 5725 79237636
Human herpesvirus 6 infection 25.46 10.09 83 500944 5287 79238074
Heart rate irregular 25.45 10.09 112 500915 32567 79210794
Blood potassium decreased 25.32 10.09 422 500605 46090 79197271
Human herpesvirus 6 encephalitis 25.29 10.09 26 501001 652 79242709
Alanine aminotransferase abnormal 25.29 10.09 12 501015 8855 79234506
Lymphocytic leukaemia 25.18 10.09 17 501010 231 79243130
Rhinitis allergic 25.08 10.09 24 501003 12245 79231116
Gastrointestinal fungal infection 25.08 10.09 23 501004 499 79242862
Delusion 25.07 10.09 57 500970 20366 79222995
Actinomycosis 25.06 10.09 33 500994 1086 79242275
Frustration tolerance decreased 24.95 10.09 8 501019 7494 79235867
Forced expiratory volume decreased 24.83 10.09 9 501018 7805 79235556
Superior sagittal sinus thrombosis 24.82 10.09 32 500995 1031 79242330
Phaeochromocytoma crisis 24.81 10.09 19 501008 318 79243043
Partial seizures 24.77 10.09 117 500910 8861 79234500
Intraocular pressure decreased 24.75 10.09 15 501012 167 79243194
C-reactive protein increased 24.73 10.09 619 500408 128408 79114953
Blood stem cell harvest failure 24.67 10.09 13 501014 108 79243253
Musculoskeletal disorder 24.63 10.09 62 500965 21386 79221975
Cytomegalovirus colitis 24.58 10.09 75 500952 4610 79238751
Cardiomegaly 24.58 10.09 84 500943 26268 79217093
Hyperamylasaemia 24.42 10.09 33 500994 1114 79242247
Metabolic acidosis 24.36 10.09 368 500659 82161 79161200
Cellulitis enterococcal 24.36 10.09 10 501017 43 79243318
Schizophrenia 24.35 10.09 37 500990 15403 79227958
Human herpesvirus 8 infection 24.32 10.09 34 500993 1186 79242175
Fluid retention 24.30 10.09 301 500726 69508 79173853
Post procedural complication 24.29 10.09 73 500954 23756 79219605
Embolism venous 24.28 10.09 70 500957 4169 79239192
Acute interstitial pneumonitis 24.25 10.09 34 500993 1189 79242172
Bacillus infection 24.24 10.09 33 500994 1122 79242239
Autoimmune lymphoproliferative syndrome 24.23 10.09 15 501012 174 79243187
Tuberculosis of central nervous system 24.23 10.09 22 501005 471 79242890
Ischaemic cardiomyopathy 24.22 10.09 9 501018 7686 79235675
Corneal disorder 24.21 10.09 48 500979 2243 79241118
Sneezing 24.11 10.09 55 500972 19628 79223733
Steroid withdrawal syndrome 23.96 10.09 26 501001 695 79242666
Renal amyloidosis 23.96 10.09 14 501013 145 79243216
Neoplasm 23.85 10.09 117 500910 8999 79234362
Chronic sinusitis 23.81 10.09 28 500999 12998 79230363
Spinal stenosis 23.80 10.09 39 500988 15752 79227609
Pneumonia cryptococcal 23.75 10.09 38 500989 1497 79241864
Iris atrophy 23.72 10.09 14 501013 148 79243213
Vitamin D deficiency 23.71 10.09 33 500994 14246 79229115
Blood pressure inadequately controlled 23.57 10.09 5 501022 6172 79237189
Salmonella sepsis 23.48 10.09 20 501007 392 79242969
Kidney transplant rejection 23.44 10.09 18 501009 10228 79233133
Taeniasis 23.32 10.09 10 501017 49 79243312
Cardiac failure 23.26 10.09 1193 499834 153649 79089712
Insurance issue 23.23 10.09 4 501023 5729 79237632
Metastases to meninges 23.13 10.09 62 500965 3539 79239822
Limb injury 23.12 10.09 101 500926 29427 79213934
Epistaxis 23.11 10.09 888 500139 110627 79132734
Choroidal detachment 23.02 10.09 24 501003 612 79242749
Depressive symptom 22.92 10.09 6 501021 6417 79236944
Vitreous haemorrhage 22.92 10.09 63 500964 3650 79239711
Endocarditis 22.91 10.09 129 500898 10468 79232893
Hyperglycaemic hyperosmolar nonketotic syndrome 22.84 10.09 47 500980 2256 79241105
Haematemesis 22.76 10.09 214 500813 52050 79191311
Abdominal sepsis 22.75 10.09 44 500983 2018 79241343
Blood stem cell transplant failure 22.69 10.09 22 501005 513 79242848
Chorioretinopathy 22.68 10.09 46 500981 2185 79241176
Epstein-Barr virus associated lymphoma 22.68 10.09 31 500996 1058 79242303
Amenorrhoea 22.58 10.09 10 501017 7682 79235679
Acute monocytic leukaemia 22.55 10.09 22 501005 517 79242844
Microangiopathic haemolytic anaemia 22.54 10.09 37 500990 1490 79241871
Gynaecomastia 22.52 10.09 10 501017 7671 79235690
VIth nerve paresis 22.47 10.09 13 501014 132 79243229
Haemorrhage 22.42 10.09 420 500607 90698 79152663
Blood potassium increased 22.40 10.09 101 500926 29174 79214187
Lipogranuloma 22.39 10.09 7 501020 10 79243351
Vitreous loss 22.39 10.09 7 501020 10 79243351
Lymphocyte adoptive therapy 22.39 10.09 7 501020 10 79243351
Superficial spreading melanoma stage unspecified 22.38 10.09 17 501010 281 79243080
Carotid artery occlusion 22.35 10.09 10 501017 7637 79235724
Nasal polyps 22.35 10.09 9 501018 7318 79236043
Platelet transfusion 22.30 10.09 47 500980 2295 79241066
Colorectal adenocarcinoma 22.20 10.09 19 501008 375 79242986
Injection site discolouration 22.19 10.09 10 501017 7604 79235757
Device failure 22.06 10.09 6 501021 6255 79237106
Chronic kidney disease 22.00 10.09 288 500739 65866 79177495
Spinal fracture 21.96 10.09 191 500836 17863 79225498
Adverse event 21.96 10.09 257 500770 59957 79183404
Blood immunoglobulin E increased 21.96 10.09 5 501022 5877 79237484
Subclavian vein thrombosis 21.89 10.09 48 500979 2409 79240952
Knee operation 21.87 10.09 5 501022 5861 79237500
Secretion discharge 21.81 10.09 38 500989 14984 79228377
Erythema 21.80 10.09 1657 499370 221633 79021728
Lentigo maligna 21.78 10.09 22 501005 540 79242821
Corneal infiltrates 21.78 10.09 17 501010 293 79243068
Creatinine renal clearance decreased 21.77 10.09 55 500972 18947 79224414
Drug level above therapeutic 21.70 10.09 14 501013 8709 79234652
Liver function test abnormal 21.70 10.09 280 500747 64195 79179166
Peritonitis bacterial 21.64 10.09 17 501010 9550 79233811
Congenital herpes simplex infection 21.62 10.09 7 501020 12 79243349
Renal cancer 21.59 10.09 27 501000 12199 79231162
Scar 21.56 10.09 39 500988 15157 79228204
Breast cancer stage III 21.55 10.09 18 501009 9808 79233553
Light chain disease 21.54 10.09 15 501012 215 79243146
Pneumococcal sepsis 21.53 10.09 38 500989 1624 79241737
Abdominal pain 21.53 10.09 2131 498896 387438 78855923
Babesiosis 21.47 10.09 18 501009 345 79243016
Impaired driving ability 21.46 10.09 4 501023 5411 79237950
Trichosporon infection 21.46 10.09 29 500998 979 79242382
Philadelphia chromosome positive 21.41 10.09 24 501003 666 79242695
Rales 21.31 10.09 60 500967 19941 79223420
Drug level below therapeutic 21.30 10.09 18 501009 9752 79233609
Stomatitis 21.30 10.09 1127 499900 145630 79097731
Ventricular tachycardia 21.26 10.09 165 500862 41770 79201591
Sarcoidosis 21.26 10.09 13 501014 8322 79235039
Salmonellosis 21.24 10.09 40 500987 1798 79241563
Glioblastoma multiforme 21.24 10.09 32 500995 1196 79242165
Adenocarcinoma gastric 21.20 10.09 39 500988 1722 79241639
Oxygen saturation 21.16 10.09 17 501010 306 79243055
Therapeutic response unexpected 21.13 10.09 60 500967 19886 79223475
Corneal perforation 21.08 10.09 25 501002 738 79242623
Body dysmorphic disorder 21.07 10.09 17 501010 308 79243053
Pneumococcal infection 21.06 10.09 28 500999 930 79242431
Herpes simplex 21.06 10.09 140 500887 12047 79231314
Head injury 20.89 10.09 143 500884 37226 79206135
Herpes simplex oesophagitis 20.87 10.09 18 501009 359 79243002
Periodontitis 20.87 10.09 69 500958 4427 79238934
Epstein Barr virus positive mucocutaneous ulcer 20.86 10.09 26 501001 809 79242552
Arteriosclerosis coronary artery 20.85 10.09 51 500976 17765 79225596
Keratitis bacterial 20.84 10.09 13 501014 153 79243208
Encephalopathy 20.84 10.09 563 500464 66834 79176527
Large intestinal ulcer perforation 20.77 10.09 10 501017 67 79243294
Blood immunoglobulin G increased 20.77 10.09 53 500974 2936 79240425
Pupillary deformity 20.75 10.09 8 501019 28 79243333
Prescribed underdose 20.72 10.09 105 500922 29409 79213952
Atrioventricular block first degree 20.61 10.09 29 500998 12462 79230899
Gastrointestinal haemorrhage 20.53 10.09 740 500287 146979 79096382
SARS-CoV-2 test positive 20.49 10.09 135 500892 11581 79231780
Spinal fusion surgery 20.48 10.09 4 501023 5234 79238127
Failure to thrive 20.43 10.09 136 500891 11708 79231653
Abnormal dreams 20.36 10.09 25 501002 11387 79231974
Hyperpyrexia 20.30 10.09 84 500943 6008 79237353
Dyslipidaemia 20.22 10.09 26 501001 11607 79231754
Tension headache 20.20 10.09 10 501017 7201 79236160
Antithrombin III decreased 20.16 10.09 20 501007 480 79242881
Tachypnoea 20.14 10.09 298 500729 31765 79211596
Injection site discomfort 20.08 10.09 4 501023 5162 79238199
Cholangitis infective 20.07 10.09 23 501004 654 79242707
Viraemia 20.07 10.09 51 500976 2818 79240543
Product packaging confusion 20.05 10.09 15 501012 242 79243119
Campylobacter gastroenteritis 20.05 10.09 33 500994 1332 79242029
Diabetic metabolic decompensation 20.04 10.09 56 500971 3276 79240085
Superior vena cava occlusion 20.03 10.09 14 501013 202 79243159
Respirovirus test positive 20.00 10.09 12 501015 131 79243230
Candida pneumonia 19.96 10.09 23 501004 658 79242703
Spinal cord injury 19.96 10.09 32 500995 1263 79242098
Needle issue 19.96 10.09 32 500995 13036 79230325
Stent placement 19.90 10.09 8 501019 6512 79236849
Rhinorrhoea 19.87 10.09 347 500680 75727 79167634
Retinal vein thrombosis 19.85 10.09 23 501004 662 79242699
Bone debridement 19.85 10.09 19 501008 436 79242925
Hemiparesis 19.83 10.09 310 500717 33423 79209938
Gastric ulcer 19.83 10.09 128 500899 33777 79209584
Dry eye 19.82 10.09 143 500884 36788 79206573
Drug-induced liver injury 19.79 10.09 294 500733 65823 79177538
Skin laceration 19.79 10.09 104 500923 28858 79214503
Staphylococcal infection 19.78 10.09 493 500534 57802 79185559
Hepatitis B 19.74 10.09 104 500923 8228 79235133
Cardiac pacemaker insertion 19.73 10.09 6 501021 5816 79237545
Escherichia test positive 19.73 10.09 54 500973 3121 79240240
Respiratory tract congestion 19.72 10.09 62 500965 19892 79223469
Seronegative arthritis 19.63 10.09 3 501024 4689 79238672
Retinal detachment 19.61 10.09 112 500915 9135 79234226
VIth nerve paralysis 19.59 10.09 36 500991 1588 79241773
Asphyxia 19.55 10.09 27 501000 11693 79231668
Electrocardiogram abnormal 19.52 10.09 48 500979 16689 79226672
Weight fluctuation 19.50 10.09 133 500894 11542 79231819
Amoebic colitis 19.50 10.09 11 501016 106 79243255
Hypophosphataemia 19.41 10.09 201 500826 19712 79223649
Myasthenia gravis 19.39 10.09 22 501005 10377 79232984
Platelet disorder 19.39 10.09 51 500976 2878 79240483
Respiratory rate increased 19.37 10.09 70 500957 21530 79221831
Menstruation irregular 19.37 10.09 4 501023 5032 79238329
Blood gases abnormal 19.35 10.09 30 500997 1150 79242211
Pollakiuria 19.31 10.09 146 500881 37171 79206190
Abscess bacterial 19.30 10.09 25 501002 809 79242552
Chest wall mass 19.30 10.09 13 501014 176 79243185
Mesenteric abscess 19.25 10.09 12 501015 141 79243220
Testicular germ cell cancer metastatic 19.24 10.09 9 501018 56 79243305
Wrong patient received product 19.21 10.09 3 501024 4615 79238746
Psychotic disorder 19.13 10.09 167 500860 41235 79202126
Tubulointerstitial nephritis 19.13 10.09 151 500876 38084 79205277
T-cell lymphoma refractory 19.11 10.09 9 501018 57 79243304
Nasal abscess 19.05 10.09 13 501014 180 79243181
Corneal thinning 19.05 10.09 13 501014 180 79243181
Morganella infection 18.97 10.09 29 500998 1098 79242263
Klebsiella sepsis 18.92 10.09 54 500973 3198 79240163
Lung transplant 18.89 10.09 3 501024 4558 79238803
Skin candida 18.85 10.09 41 500986 2046 79241315
Rib fracture 18.85 10.09 263 500764 27684 79215677
Inflammatory bowel disease 18.84 10.09 6 501021 5645 79237716
Colorectal cancer 18.77 10.09 16 501011 8631 79234730
Drug resistance 18.75 10.09 371 500656 41842 79201519
Product dose omission in error 18.70 10.09 13 501014 7775 79235586
Hysterectomy 18.65 10.09 8 501019 6264 79237097
Feeling cold 18.62 10.09 105 500922 28624 79214737
Bradykinesia 18.57 10.09 14 501013 8029 79235332
Pharyngitis streptococcal 18.57 10.09 24 501003 10690 79232671
Pneumonia staphylococcal 18.50 10.09 70 500957 4804 79238557
Granuloma 18.45 10.09 15 501012 8282 79235079
Adenocarcinoma pancreas 18.44 10.09 40 500987 1993 79241368
Cholecystitis chronic 18.43 10.09 21 501006 9885 79233476
Compression fracture 18.42 10.09 85 500942 6375 79236986
Septic pulmonary embolism 18.42 10.09 11 501016 119 79243242
Rotator cuff syndrome 18.41 10.09 38 500989 14057 79229304
Pre-existing condition improved 18.38 10.09 6 501021 5557 79237804
Quadriparesis 18.33 10.09 56 500971 3445 79239916
Intermenstrual bleeding 18.32 10.09 7 501020 5877 79237484
Cardiac failure congestive 18.32 10.09 720 500307 141682 79101679
Radiation necrosis 18.32 10.09 18 501009 427 79242934
Birdshot chorioretinopathy 18.25 10.09 9 501018 64 79243297
Vertebral lesion 18.25 10.09 21 501006 600 79242761
Alcohol use 18.25 10.09 4 501023 4827 79238534
Swollen tongue 18.24 10.09 175 500852 42395 79200966
Carotid intima-media thickness increased 18.21 10.09 10 501017 91 79243270
Renal cyst 18.18 10.09 41 500986 14691 79228670
Social avoidant behaviour 18.15 10.09 4 501023 4810 79238551
Encephalitis brain stem 18.15 10.09 14 501013 237 79243124
Liver transplant 18.11 10.09 3 501024 4420 79238941
Cavernous sinus thrombosis 18.08 10.09 17 501010 381 79242980
Cauda equina syndrome 18.07 10.09 32 500995 1371 79241990
Sense of oppression 18 10.09 34 500993 1532 79241829
Arthropod bite 17.99 10.09 16 501011 8455 79234906
Dyspnoea exertional 17.98 10.09 413 500614 86660 79156701
Photosensitivity reaction 17.95 10.09 70 500957 21057 79222304
Uterine leiomyoma 17.95 10.09 9 501018 6434 79236927
Eastern Cooperative Oncology Group performance status improved 17.94 10.09 6 501021 12 79243349
Tear break up time decreased 17.94 10.09 6 501021 12 79243349
Pseudocellulitis 17.91 10.09 9 501018 67 79243294
Macular degeneration 17.88 10.09 27 501000 11269 79232092
Chronic inflammatory demyelinating polyradiculoneuropathy 17.88 10.09 29 500998 1156 79242205
Thrombophlebitis 17.80 10.09 83 500944 6252 79237109
Drug tolerance decreased 17.80 10.09 34 500993 12944 79230417
Emotional disorder 17.78 10.09 40 500987 14347 79229014
Mucosal infection 17.75 10.09 19 501008 500 79242861
Hepatic cytolysis 17.72 10.09 99 500928 27052 79216309
Radiation inflammation 17.71 10.09 25 501002 880 79242481
Aortic arteriosclerosis 17.59 10.09 18 501009 8900 79234461
Eye pruritus 17.58 10.09 68 500959 20502 79222859
Blood immunoglobulin A increased 17.55 10.09 26 501001 957 79242404
Pulmonary haemorrhage 17.54 10.09 155 500872 14562 79228799
Thyroid disorder 17.52 10.09 39 500988 14040 79229321
Peripheral venous disease 17.49 10.09 47 500980 15862 79227499
Bacterial endophthalmitis 17.47 10.09 12 501015 168 79243193
Tracheal deviation 17.41 10.09 12 501015 169 79243192
Alcohol abuse 17.34 10.09 6 501021 5357 79238004
Palmar erythema 17.31 10.09 38 500989 1909 79241452
Ankle fracture 17.28 10.09 52 500975 16917 79226444
Intracranial tumour haemorrhage 17.27 10.09 19 501008 516 79242845
Syringe issue 17.24 10.09 9 501018 6289 79237072
Accident 17.22 10.09 18 501009 8813 79234548
Escherichia urinary tract infection 17.21 10.09 147 500880 13678 79229683
Hereditary angioedema 17.20 10.09 6 501021 5329 79238032
Mitral valve incompetence 17.14 10.09 107 500920 28458 79214903
Neurological symptom 17.09 10.09 104 500923 8679 79234682
Musculoskeletal chest pain 17.09 10.09 234 500793 24530 79218831
Pulmonary congestion 17.05 10.09 100 500927 27000 79216361
Cataract 17.01 10.09 511 500516 61609 79181752
Ligament sprain 17.00 10.09 37 500990 13427 79229934
Nail dystrophy 16.96 10.09 26 501001 987 79242374
Iris adhesions 16.95 10.09 19 501008 527 79242834
Facet joint syndrome 16.95 10.09 28 500999 11274 79232087
Balance disorder 16.91 10.09 482 500545 98375 79144986
Sinus disorder 16.89 10.09 78 500949 22386 79220975
Cardiopulmonary failure 16.88 10.09 86 500941 6715 79236646
Pneumonia mycoplasmal 16.88 10.09 32 500995 1446 79241915
Cerebral haematoma 16.87 10.09 15 501012 7927 79235434
Respiratory tract infection viral 16.86 10.09 62 500965 4197 79239164
Hepatitis E 16.80 10.09 49 500978 2937 79240424
Cryptosporidiosis infection 16.77 10.09 22 501005 721 79242640
Madarosis 16.76 10.09 47 500980 2755 79240606
Blood pressure diastolic increased 16.73 10.09 42 500985 14500 79228861
Snoring 16.71 10.09 7 501020 5559 79237802
Malignant pleural effusion 16.71 10.09 53 500974 3327 79240034
Meniscus injury 16.65 10.09 11 501016 6757 79236604
Dysstasia 16.61 10.09 104 500923 27642 79215719
Post-traumatic stress disorder 16.60 10.09 5 501022 4876 79238485
Rectal haemorrhage 16.58 10.09 359 500668 75941 79167420
Post procedural hypotension 16.57 10.09 9 501018 80 79243281
Ankle brachial index decreased 16.57 10.09 9 501018 80 79243281
Hyperhidrosis 16.56 10.09 780 500247 150712 79092649
Type I hypersensitivity 16.56 10.09 63 500964 4335 79239026
Respiratory depth decreased 16.54 10.09 7 501020 33 79243328
Middle insomnia 16.54 10.09 49 500978 16020 79227341
Lung adenocarcinoma 16.52 10.09 95 500932 7769 79235592
Bone infarction 16.48 10.09 18 501009 485 79242876
Tonsillar disorder 16.47 10.09 29 500998 1237 79242124
Corneal abscess 16.45 10.09 8 501019 55 79243306
Chemotherapy 16.43 10.09 35 500992 1722 79241639
Oropharyngeal candidiasis 16.43 10.09 35 500992 1722 79241639
Panophthalmitis 16.39 10.09 11 501016 148 79243213
Soft tissue infection 16.38 10.09 58 500969 3854 79239507
Balamuthia infection 16.37 10.09 7 501020 34 79243327
BK virus infection 16.35 10.09 103 500924 8701 79234660
Post procedural infection 16.35 10.09 29 500998 11355 79232006
Low density lipoprotein increased 16.34 10.09 18 501009 8604 79234757
Ileus paralytic 16.31 10.09 110 500917 9510 79233851
Localised infection 16.30 10.09 154 500873 37421 79205940
Pulse waveform abnormal 16.29 10.09 9 501018 83 79243278
Precursor B-lymphoblastic lymphoma 16.25 10.09 6 501021 18 79243343
Gastrointestinal wall thinning 16.25 10.09 6 501021 18 79243343
5q minus syndrome 16.24 10.09 14 501013 279 79243082
Pleocytosis 16.24 10.09 31 500996 1408 79241953
Amoebiasis 16.23 10.09 10 501017 115 79243246
Dental caries 16.18 10.09 31 500996 11789 79231572
Skin ulcer 16.13 10.09 241 500786 53909 79189452
Transplant dysfunction 16.12 10.09 13 501014 7208 79236153
Listeria sepsis 16.11 10.09 22 501005 750 79242611
Drug specific antibody present 16.11 10.09 11 501016 6641 79236720
Mucosal haemorrhage 16.08 10.09 44 500983 2542 79240819
Cognitive disorder 16.08 10.09 326 500701 69600 79173761
Pulmonary infarction 16.06 10.09 57 500970 3792 79239569
Incorrect product administration duration 16.05 10.09 32 500995 11990 79231371
Dacryocanaliculitis 16.05 10.09 5 501022 7 79243354
Cholangiocarcinoma 15.95 10.09 43 500984 2463 79240898
Mental disorder 15.95 10.09 123 500904 31179 79212182
Blood calcium increased 15.92 10.09 116 500911 10284 79233077
Wrong technique in device usage process 15.91 10.09 3 501024 4025 79239336
Cyst 15.90 10.09 40 500987 13800 79229561
Dissociation 15.87 10.09 3 501024 4018 79239343
Polyarthritis 15.85 10.09 33 500994 12169 79231192
Cerebellar haemangioma 15.84 10.09 9 501018 88 79243273
Vein discolouration 15.82 10.09 15 501012 340 79243021
Blood prolactin increased 15.82 10.09 3 501024 4008 79239353
Haemodynamic instability 15.80 10.09 173 500854 17209 79226152
Plasma cell myeloma in remission 15.79 10.09 6 501021 20 79243341
Product use issue 15.76 10.09 1120 499907 208702 79034659
Pulmonary trichosporonosis 15.76 10.09 8 501019 61 79243300
Spinal osteoarthritis 15.76 10.09 54 500973 16873 79226488
Micturition urgency 15.74 10.09 35 500992 12606 79230755
Hypotony of eye 15.69 10.09 13 501014 245 79243116
Stress echocardiogram abnormal 15.65 10.09 5 501022 8 79243353
Diverticulum 15.64 10.09 45 500982 14851 79228510
Blast cells present 15.61 10.09 24 501003 913 79242448
General physical condition abnormal 15.61 10.09 82 500945 6481 79236880
Catabolic state 15.59 10.09 9 501018 91 79243270
Breast cancer metastatic 15.58 10.09 100 500927 8502 79234859
Refractory anaemia with ringed sideroblasts 15.57 10.09 6 501021 21 79243340
Pulmonary function test decreased 15.54 10.09 15 501012 7622 79235739
Pneumonia legionella 15.54 10.09 47 500980 2875 79240486
Acute pulmonary oedema 15.50 10.09 147 500880 14083 79229278
Cachexia 15.49 10.09 121 500906 10962 79232399
Varicella 15.44 10.09 47 500980 2885 79240476
CSF oligoclonal band present 15.44 10.09 16 501011 405 79242956
Tumour perforation 15.44 10.09 16 501011 405 79242956
Intestinal atresia 15.43 10.09 8 501019 64 79243297
JC virus CSF test positive 15.38 10.09 11 501016 165 79243196
Clostridial sepsis 15.37 10.09 24 501003 926 79242435
Expired product administered 15.36 10.09 13 501014 7038 79236323
Osteomyelitis bacterial 15.36 10.09 17 501010 465 79242896
Lacrimation increased 15.35 10.09 212 500815 22265 79221096
Epstein-Barr virus infection 15.25 10.09 148 500879 14268 79229093
Impaired gastric emptying 15.21 10.09 26 501001 10327 79233034
Tumour pain 15.19 10.09 40 500987 2259 79241102
Molluscum contagiosum 15.16 10.09 17 501010 472 79242889
Pneumoretroperitoneum 15.15 10.09 11 501016 169 79243192
Enterobacter sepsis 15.13 10.09 27 501000 1164 79242197
Full blood count abnormal 15.05 10.09 172 500855 40302 79203059
Metastases to bone marrow 15.05 10.09 22 501005 800 79242561
Hyperproteinaemia 15.05 10.09 11 501016 171 79243190
Rash 15.03 10.09 3968 497059 574390 78668971
Corneal lesion 15.03 10.09 8 501019 68 79243293
Amyotrophy 15.00 10.09 19 501008 601 79242760
Cytokine storm 14.97 10.09 25 501002 1021 79242340
Mood swings 14.96 10.09 69 500958 19811 79223550
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 14.95 10.09 5 501022 10 79243351
Cavernous sinus syndrome 14.95 10.09 5 501022 10 79243351
Anticipatory anxiety 14.92 10.09 27 501000 1177 79242184
Wrist fracture 14.85 10.09 33 500994 11888 79231473
Subcutaneous emphysema 14.81 10.09 34 500993 1760 79241601
Gas gangrene 14.80 10.09 13 501014 266 79243095
Full blood count increased 14.77 10.09 18 501009 547 79242814
Abdominal distension 14.74 10.09 608 500419 119042 79124319
Acute erythroid leukaemia 14.72 10.09 13 501014 268 79243093
Diffuse alveolar damage 14.72 10.09 53 500974 3551 79239810
Pneumonia respiratory syncytial viral 14.71 10.09 35 500992 1855 79241506
Application site pruritus 14.71 10.09 3 501024 3807 79239554
Retinal infiltrates 14.65 10.09 7 501020 46 79243315
Enterococcal sepsis 14.64 10.09 44 500983 2682 79240679
Caesarean section 14.58 10.09 36 500991 12499 79230862
Confusional state 14.57 10.09 1762 499265 316235 78927126
Blood calcium abnormal 14.55 10.09 29 500998 1360 79242001
Citrobacter sepsis 14.55 10.09 8 501019 73 79243288
Malignant melanoma in situ 14.54 10.09 41 500986 2411 79240950
Pruritus genital 14.54 10.09 5 501022 4481 79238880
Apathy 14.53 10.09 38 500989 12939 79230422
Tricuspid valve incompetence 14.49 10.09 69 500958 19643 79223718
Somnambulism 14.48 10.09 9 501018 5712 79237649
Oropharyngeal pain 14.48 10.09 551 500476 108802 79134559
Dermatitis acneiform 14.47 10.09 110 500917 9883 79233478
Gestational diabetes 14.47 10.09 11 501016 6282 79237079
Anaphylactoid shock 14.44 10.09 21 501006 760 79242601
Agitation 14.43 10.09 497 500530 99218 79144143
Acinetobacter bacteraemia 14.41 10.09 13 501014 276 79243085
Infusion related hypersensitivity reaction 14.41 10.09 15 501012 382 79242979
VIth nerve disorder 14.40 10.09 6 501021 27 79243334
Encephalitis enteroviral 14.38 10.09 10 501017 143 79243218
Bone marrow disorder 14.37 10.09 50 500977 3293 79240068
Spinal pain 14.36 10.09 154 500873 15238 79228123
Posterior capsule rupture 14.34 10.09 5 501022 12 79243349
Genital haemorrhage 14.29 10.09 11 501016 6244 79237117
Haemolysis 14.28 10.09 133 500894 12679 79230682
Haemolytic anaemia 14.24 10.09 173 500854 17647 79225714
Monoclonal immunoglobulin increased 14.21 10.09 10 501017 146 79243215
Palmoplantar keratoderma 14.19 10.09 3 501024 3713 79239648
Hernia 14.19 10.09 57 500970 17002 79226359
Macular fibrosis 14.19 10.09 20 501007 703 79242658
Metastases to retroperitoneum 14.19 10.09 15 501012 389 79242972
Affect lability 14.17 10.09 31 500996 11228 79232133
Hand fracture 14.16 10.09 11 501016 6214 79237147
Chromaturia 14.16 10.09 99 500928 25647 79217714
Cardioactive drug level increased 14.15 10.09 3 501024 3706 79239655
B-cell lymphoma refractory 14.15 10.09 10 501017 147 79243214
Synovial cyst 14.13 10.09 26 501001 10039 79233322
Spondylitis 14.12 10.09 6 501021 4725 79238636
Drooling 14.12 10.09 10 501017 5924 79237437
Tongue disorder 14.11 10.09 43 500984 13932 79229429
Irritability 14.09 10.09 178 500849 40966 79202395
Blood immunoglobulin D increased 14.09 10.09 4 501023 3 79243358
Periorbital infection 14.07 10.09 9 501018 111 79243250
Leukaemia 14.07 10.09 74 500953 5851 79237510
Plethoric face 14.06 10.09 6 501021 29 79243332
Haemophilus sepsis 14.05 10.09 7 501020 51 79243310
Gallbladder disorder 14.04 10.09 68 500959 19272 79224089
Administration site extravasation 14.02 10.09 28 500999 1315 79242046
Dental fistula 13.99 10.09 17 501010 515 79242846
Diabetes mellitus inadequate control 13.99 10.09 92 500935 24172 79219189
Maternal exposure before pregnancy 13.96 10.09 5 501022 4368 79238993
Paraparesis 13.92 10.09 54 500973 3749 79239612
Gastrointestinal toxicity 13.92 10.09 93 500934 8016 79235345
Candida sepsis 13.91 10.09 41 500986 2472 79240889
Peripheral vascular disorder 13.90 10.09 18 501009 8012 79235349
Haematoma muscle 13.85 10.09 42 500985 2573 79240788
Streptococcus test positive 13.84 10.09 38 500989 2200 79241161
Sinus polyp 13.84 10.09 17 501010 521 79242840
Pallor 13.84 10.09 226 500801 49836 79193525
Gastroenteritis norovirus 13.83 10.09 47 500980 3059 79240302
Insomnia 13.82 10.09 1339 499688 243831 78999530
Antithrombin III deficiency 13.80 10.09 9 501018 115 79243246
Vitamin D decreased 13.76 10.09 25 501002 9700 79233661
High density lipoprotein decreased 13.74 10.09 6 501021 4649 79238712
Eye irritation 13.72 10.09 75 500952 20606 79222755
Hepatitis cholestatic 13.72 10.09 43 500984 13809 79229552
Major depression 13.70 10.09 22 501005 8958 79234403
Appendiceal abscess 13.69 10.09 14 501013 349 79243012
Iron deficiency 13.68 10.09 29 500998 10625 79232736
Hepatitis 13.67 10.09 257 500770 55470 79187891
Postictal state 13.65 10.09 34 500993 1855 79241506
Epstein-Barr virus infection reactivation 13.62 10.09 34 500993 1858 79241503
Thiopurine methyltransferase decreased 13.59 10.09 14 501013 352 79243009
Cryptococcal meningoencephalitis 13.56 10.09 12 501015 248 79243113
Injection site extravasation 13.55 10.09 25 501002 9644 79233717
Complications of transplanted kidney 13.55 10.09 12 501015 6354 79237007
Hypergeusia 13.54 10.09 5 501022 15 79243346
Pain in jaw 13.54 10.09 206 500821 45945 79197416
Myeloma cast nephropathy 13.49 10.09 10 501017 159 79243202
Maternal exposure timing unspecified 13.47 10.09 10 501017 5782 79237579
Abdominal pain lower 13.47 10.09 131 500896 31651 79211710
Hepatitis viral 13.46 10.09 24 501003 1034 79242327
N-terminal prohormone brain natriuretic peptide decreased 13.43 10.09 6 501021 33 79243328
Hepatic steatosis 13.40 10.09 162 500865 37576 79205785
Mood altered 13.40 10.09 62 500965 17785 79225576
Radiation oesophagitis 13.39 10.09 19 501008 672 79242689
Biliary tract infection 13.38 10.09 28 500999 1360 79242001
Haematopoietic stem cell mobilisation 13.38 10.09 11 501016 205 79243156
Systemic mycosis 13.36 10.09 42 500985 2624 79240737
Immunodeficiency 13.34 10.09 81 500946 21687 79221674
Toe amputation 13.31 10.09 4 501023 3907 79239454
Janeway lesion 13.31 10.09 5 501022 16 79243345
Abortion induced 13.30 10.09 15 501012 7094 79236267
Hypokinesia 13.27 10.09 68 500959 18992 79224369
Upper-airway cough syndrome 13.27 10.09 34 500993 11659 79231702
Blood urea increased 13.24 10.09 221 500806 48569 79194792
Diverticulum intestinal 13.21 10.09 21 501006 8584 79234777
Exercise tolerance decreased 13.12 10.09 23 501004 9048 79234313
Skin induration 13.10 10.09 6 501021 4519 79238842
Intentional dose omission 13.08 10.09 22 501005 8795 79234566
Squamous cell carcinoma of the hypopharynx 13.08 10.09 5 501022 17 79243344
Pneumocystis jirovecii infection 13.07 10.09 44 500983 2850 79240511
Adenoviral hepatitis 13.06 10.09 22 501005 905 79242456
SARS-CoV-2 sepsis 13.05 10.09 9 501018 127 79243234
Human herpesvirus 7 infection 13.05 10.09 9 501018 127 79243234
Oesophageal squamous cell carcinoma 13.04 10.09 16 501011 490 79242871
Perihepatic abscess 13.03 10.09 10 501017 168 79243193
Pre-eclampsia 13.02 10.09 15 501012 7026 79236335
Subdural effusion 13.00 10.09 7 501020 61 79243300
Pericardial haemorrhage 12.95 10.09 6 501021 4489 79238872
Thinking abnormal 12.93 10.09 41 500986 13120 79230241
Venoocclusive disease 12.91 10.09 60 500967 4513 79238848
Metastases to spleen 12.91 10.09 18 501009 626 79242735
Breast mass 12.91 10.09 14 501013 6740 79236621
Adjusted calcium increased 12.91 10.09 7 501020 62 79243299
Red blood cell count decreased 12.88 10.09 462 500565 57051 79186310
Septic embolus 12.86 10.09 35 500992 2016 79241345
Nerve compression 12.85 10.09 24 501003 9215 79234146
Onychomycosis 12.83 10.09 20 501007 8241 79235120
Gastritis 12.83 10.09 218 500809 47775 79195586
Sciatica 12.82 10.09 140 500887 33082 79210279
Overweight 12.82 10.09 5 501022 4145 79239216
Drug clearance decreased 12.81 10.09 48 500979 3279 79240082
Blood pressure measurement 12.78 10.09 15 501012 438 79242923
Infectious pleural effusion 12.77 10.09 52 500975 3692 79239669
Body temperature fluctuation 12.77 10.09 4 501023 3803 79239558
Hordeolum 12.74 10.09 47 500980 3186 79240175
POEMS syndrome 12.74 10.09 6 501021 38 79243323
Squamous cell carcinoma of head and neck 12.73 10.09 12 501015 270 79243091
Normochromic normocytic anaemia 12.69 10.09 18 501009 7709 79235652
Alveolitis 12.67 10.09 56 500971 4124 79239237
Hypogeusia 12.66 10.09 32 500995 1762 79241599
Oral pain 12.66 10.09 275 500752 31523 79211838
Peritumoural oedema 12.66 10.09 5 501022 19 79243342
Nephrogenic systemic fibrosis 12.65 10.09 12 501015 6148 79237213
Humerus fracture 12.65 10.09 101 500926 9212 79234149
Arterial occlusive disease 12.64 10.09 21 501006 8435 79234926
Oncologic complication 12.58 10.09 13 501014 328 79243033
Opportunistic infection 12.58 10.09 44 500983 2906 79240455
Calciphylaxis 12.57 10.09 4 501023 3766 79239595
Ilium fracture 12.55 10.09 12 501015 275 79243086
Feeling drunk 12.55 10.09 7 501020 4712 79238649
Transitional cell cancer of the renal pelvis and ureter 12.54 10.09 7 501020 66 79243295
Oesophageal candidiasis 12.54 10.09 100 500927 9118 79234243
Immunoglobulins increased 12.53 10.09 18 501009 644 79242717
Intestinal resection 12.51 10.09 4 501023 3753 79239608
Infection in an immunocompromised host 12.50 10.09 27 501000 1341 79242020
Colon cancer metastatic 12.48 10.09 36 500991 2145 79241216
Lymphoma 12.47 10.09 166 500861 17294 79226067
Dyspnoea 12.46 10.09 5753 495274 851272 78392089
Lung squamous cell carcinoma stage III 12.46 10.09 5 501022 20 79243341
Precursor T-lymphoblastic lymphoma/leukaemia recurrent 12.46 10.09 5 501022 20 79243341
Limb discomfort 12.45 10.09 139 500888 32711 79210650
Hospice care 12.44 10.09 109 500918 10215 79233146
Tumour flare 12.44 10.09 24 501003 1099 79242262
Skin plaque 12.38 10.09 31 500996 10714 79232647
Prostate cancer metastatic 12.38 10.09 54 500973 3953 79239408
Hypophagia 12.37 10.09 373 500654 44994 79198367
Bacterial parotitis 12.37 10.09 6 501021 41 79243320
Coinfection 12.36 10.09 7 501020 68 79243293
Mucocutaneous ulceration 12.36 10.09 14 501013 393 79242968
Antinuclear antibody positive 12.35 10.09 19 501008 7871 79235490
Vitreous haze 12.35 10.09 8 501019 101 79243260
Acinetobacter infection 12.34 10.09 42 500985 2735 79240626
Cataract traumatic 12.30 10.09 4 501023 7 79243354
Acanthamoeba keratitis 12.30 10.09 4 501023 7 79243354
Eosinophilic cystitis 12.28 10.09 8 501019 102 79243259
Mydriasis 12.25 10.09 63 500964 17580 79225781
Fungal sepsis 12.25 10.09 32 500995 1798 79241563
Target skin lesion 12.25 10.09 9 501018 141 79243220
Benign prostatic hyperplasia 12.25 10.09 35 500992 11577 79231784
Haemophilus bacteraemia 12.24 10.09 6 501021 42 79243319
Purine metabolism disorder 12.23 10.09 3 501024 0 79243361
Fibrin increased 12.23 10.09 3 501024 0 79243361
Hymenolepiasis 12.23 10.09 3 501024 0 79243361
Sensory ganglionitis 12.23 10.09 3 501024 0 79243361
Vaccine virus shedding 12.23 10.09 3 501024 0 79243361
Blood selenium increased 12.23 10.09 3 501024 0 79243361
Reoviral infection 12.23 10.09 3 501024 0 79243361
Leukaemic infiltration extramedullary 12.22 10.09 10 501017 185 79243176
Blood cholesterol abnormal 12.20 10.09 3 501024 3347 79240014
Mesenteric vascular insufficiency 12.20 10.09 9 501018 142 79243219
Coronary artery stenosis 12.19 10.09 39 500988 12445 79230916
Bradypnoea 12.19 10.09 12 501015 6040 79237321
Body height decreased 12.18 10.09 94 500933 8486 79234875
Haemoglobin abnormal 12.17 10.09 81 500946 6973 79236388
Disseminated coccidioidomycosis 12.14 10.09 9 501018 143 79243218
Hyphaema 12.14 10.09 21 501006 883 79242478
Procalcitonin increased 12.10 10.09 44 500983 2962 79240399
Mucosal erosion 12.06 10.09 37 500990 2281 79241080
Focal segmental glomerulosclerosis 12.05 10.09 3 501024 3318 79240043
Embedded device 12.04 10.09 3 501024 3316 79240045
Catheter management 12.02 10.09 4 501023 3659 79239702
Hyperthermia malignant 12.00 10.09 43 500984 2874 79240487
Abscess fungal 12.00 10.09 13 501014 347 79243014
Hair texture abnormal 11.99 10.09 49 500978 3485 79239876
Engraftment syndrome 11.96 10.09 27 501000 1382 79241979
Plasma cells present 11.96 10.09 4 501023 8 79243353
Night sweats 11.94 10.09 243 500784 51852 79191509
Bundle branch block left 11.93 10.09 35 500992 11478 79231883
Tracheobronchitis 11.93 10.09 34 500993 2012 79241349
Coordination abnormal 11.92 10.09 62 500965 17250 79226111
SARS-CoV-2 viraemia 11.90 10.09 6 501021 45 79243316
Fibrin D dimer increased 11.83 10.09 94 500933 8560 79234801
Retroperitoneal mass 11.83 10.09 11 501016 243 79243118
Cerebrovascular accident 11.81 10.09 828 500199 154464 79088897
White blood cell count abnormal 11.80 10.09 69 500958 5676 79237685
Recalled product administered 11.80 10.09 20 501007 827 79242534
Psychomotor hyperactivity 11.80 10.09 60 500967 16789 79226572
Long QT syndrome 11.77 10.09 12 501015 5943 79237418
Vertigo 11.77 10.09 337 500690 68745 79174616
Gait inability 11.73 10.09 281 500746 58636 79184725
Transplant 11.73 10.09 22 501005 986 79242375
Infective aneurysm 11.73 10.09 22 501005 986 79242375
Histoplasmosis disseminated 11.73 10.09 37 500990 2316 79241045
Brain neoplasm 11.72 10.09 68 500959 5578 79237783
Transient ischaemic attack 11.72 10.09 247 500780 52448 79190913
Coronavirus infection 11.70 10.09 84 500943 7413 79235948
Choking 11.68 10.09 38 500989 12063 79231298
Glomerular filtration rate decreased 11.66 10.09 89 500938 22613 79220748
Mucocutaneous haemorrhage 11.66 10.09 10 501017 198 79243163
Orthopnoea 11.66 10.09 29 500998 10044 79233317
Lung squamous cell carcinoma stage II 11.65 10.09 4 501023 9 79243352
Ependymitis 11.65 10.09 4 501023 9 79243352
Tinnitus 11.65 10.09 202 500825 44131 79199230
Idiopathic pulmonary fibrosis 11.64 10.09 6 501021 4222 79239139
Flat anterior chamber of eye 11.63 10.09 9 501018 153 79243208
Hip deformity 11.62 10.09 10 501017 199 79243162
Throat irritation 11.60 10.09 184 500843 40762 79202599
Blood glucose fluctuation 11.55 10.09 15 501012 6667 79236694
Cutaneous mucormycosis 11.53 10.09 10 501017 201 79243160
Retinal ischaemia 11.50 10.09 19 501008 769 79242592
White blood cell count increased 11.50 10.09 369 500658 74264 79169097
Enlarged uvula 11.48 10.09 14 501013 426 79242935
Chemical burns of eye 11.47 10.09 8 501019 115 79243246
Cystic fibrosis 11.46 10.09 5 501022 3875 79239486
Haemodialysis 11.45 10.09 67 500960 18101 79225260
Cardiac failure chronic 11.43 10.09 34 500993 11101 79232260
Gastrointestinal mucormycosis 11.43 10.09 14 501013 428 79242933
Bronchopneumopathy 11.42 10.09 19 501008 774 79242587
Corneal epithelium defect 11.40 10.09 18 501009 701 79242660
Gene mutation 11.40 10.09 40 500987 2646 79240715
Enteric neuropathy 11.36 10.09 4 501023 10 79243351
Light chain analysis 11.36 10.09 4 501023 10 79243351
Onychalgia 11.36 10.09 21 501006 931 79242430
Viral myelitis 11.35 10.09 8 501019 117 79243244
Hypersensitivity myocarditis 11.33 10.09 11 501016 257 79243104
Acute myelomonocytic leukaemia 11.33 10.09 12 501015 312 79243049
Cerebral fungal infection 11.30 10.09 14 501013 433 79242928
Laryngitis 11.30 10.09 57 500970 15982 79227379
Refeeding syndrome 11.25 10.09 7 501020 82 79243279
Glucose tolerance impaired 11.25 10.09 21 501006 8063 79235298
Pulmonary function test abnormal 11.23 10.09 6 501021 4138 79239223
Epstein-Barr virus associated lymphoproliferative disorder 11.22 10.09 48 500979 3484 79239877
Delayed graft function 11.21 10.09 4 501023 3503 79239858
Skin toxicity 11.20 10.09 90 500937 8224 79235137
Embolic pneumonia 11.18 10.09 7 501020 83 79243278
Palmar-plantar erythrodysaesthesia syndrome 11.17 10.09 280 500747 32854 79210507
Therapy responder 11.15 10.09 14 501013 439 79242922
Toxicity to various agents 11.13 10.09 2410 498617 419130 78824231
Aplasia pure red cell 11.12 10.09 20 501007 7790 79235571
Vascular device infection 11.12 10.09 106 500921 10170 79233191
Alopecia totalis 11.12 10.09 13 501014 378 79242983
Leukaemic lymphoma 11.11 10.09 7 501020 84 79243277
Gastroenteritis viral 11.10 10.09 101 500926 24730 79218631
Gingival hypertrophy 11.09 10.09 3 501024 3139 79240222
Uterine fistula 11.09 10.09 4 501023 11 79243350
Tenderness 11.08 10.09 95 500932 23547 79219814
Tension 11.05 10.09 7 501020 4397 79238964
Subileus 11.04 10.09 67 500960 5587 79237774
Leishmaniasis 11.04 10.09 13 501014 381 79242980
Adenoviral haemorrhagic cystitis 11.02 10.09 15 501012 510 79242851
Papilloedema 11.01 10.09 72 500955 6161 79237200
Immune-mediated myositis 11.00 10.09 4 501023 3463 79239898
Vaccination failure 11.00 10.09 31 500996 1822 79241539
Cancer fatigue 10.98 10.09 9 501018 167 79243194
Urine leukocyte esterase positive 10.98 10.09 6 501021 4085 79239276
Pulpitis dental 10.97 10.09 25 501002 1288 79242073
Pneumonia necrotising 10.97 10.09 24 501003 1203 79242158
Prescription drug used without a prescription 10.95 10.09 6 501021 4079 79239282
Macular hole 10.93 10.09 19 501008 802 79242559
Toxic neuropathy 10.92 10.09 21 501006 959 79242402
Oedema 10.92 10.09 627 500400 118953 79124408
Hepatic cancer 10.92 10.09 32 500995 10497 79232864
Back injury 10.90 10.09 32 500995 10491 79232870
Bladder transitional cell carcinoma stage 0 10.85 10.09 8 501019 126 79243235
Bone marrow leukaemic cell infiltration 10.84 10.09 5 501022 30 79243331
Paranoid personality disorder 10.84 10.09 5 501022 30 79243331
Muscle tightness 10.84 10.09 43 500984 12871 79230490
Lineage switch leukaemia 10.84 10.09 4 501023 12 79243349
Bone cyst 10.83 10.09 4 501023 3429 79239932
Varices oesophageal 10.82 10.09 13 501014 5978 79237383
Cogwheel rigidity 10.80 10.09 3 501024 3085 79240276
Persistent corneal epithelial defect 10.80 10.09 6 501021 56 79243305
Lower gastrointestinal perforation 10.80 10.09 6 501021 56 79243305
Limb operation 10.79 10.09 4 501023 3422 79239939
Lung cancer metastatic 10.79 10.09 49 500978 3650 79239711
Intracranial mass 10.78 10.09 35 500992 2224 79241137
Blood iron decreased 10.78 10.09 55 500972 15379 79227982
Extra dose administered 10.73 10.09 23 501004 8392 79234969
Tumour haemorrhage 10.71 10.09 53 500974 4091 79239270
Anti-neutrophil cytoplasmic antibody positive vasculitis 10.71 10.09 5 501022 3724 79239637
Peritonitis viral 10.71 10.09 6 501021 57 79243304
Tuberculin test positive 10.70 10.09 4 501023 3404 79239957
Electrocardiogram Q waves 10.70 10.09 7 501020 90 79243271
Throat tightness 10.68 10.09 240 500787 27667 79215694
Tooth erosion 10.67 10.09 13 501014 395 79242966
Mucous stools 10.67 10.09 10 501017 5152 79238209
Bone marrow necrosis 10.66 10.09 11 501016 277 79243084
Gingival erosion 10.64 10.09 8 501019 130 79243231
Diastolic hypotension 10.63 10.09 9 501018 175 79243186
Myopathy 10.62 10.09 185 500842 20378 79222983
Botryomycosis 10.62 10.09 6 501021 58 79243303
Petechiae 10.61 10.09 185 500842 20380 79222981
Ventricular fibrillation 10.61 10.09 139 500888 31787 79211574
Acute kidney injury 10.60 10.09 3529 497498 515875 78727486
Nasal flaring 10.60 10.09 4 501023 13 79243348
Tendon disorder 10.60 10.09 18 501009 7168 79236193
Heart sounds abnormal 10.58 10.09 26 501001 1407 79241954
Refractory cancer 10.57 10.09 10 501017 226 79243135
Therapy cessation 10.57 10.09 169 500858 37393 79205968
Radiation injury 10.57 10.09 19 501008 824 79242537
Blood triglycerides increased 10.57 10.09 83 500944 20957 79222404
Staphylococcal scalded skin syndrome 10.54 10.09 13 501014 400 79242961
Palatal ulcer 10.54 10.09 8 501019 132 79243229
Chloroma 10.49 10.09 18 501009 752 79242609
Natural killer-cell lymphoblastic lymphoma 10.45 10.09 5 501022 33 79243328
Bacteroides bacteraemia 10.44 10.09 7 501020 94 79243267
Meningoencephalitis bacterial 10.43 10.09 10 501017 230 79243131
Emphysematous cystitis 10.42 10.09 12 501015 343 79243018
Pancreatic carcinoma metastatic 10.42 10.09 49 500978 3704 79239657
Ketoacidosis 10.41 10.09 21 501006 7833 79235528
Pulmonary alveolar haemorrhage 10.40 10.09 114 500913 11343 79232018
Fungal disease carrier 10.40 10.09 12 501015 344 79243017
Intervertebral disc disorder 10.39 10.09 9 501018 4816 79238545
Epstein-Barr viraemia 10.38 10.09 34 500993 2171 79241190
Acute leukaemia 10.37 10.09 29 500998 1697 79241664
Chemotherapeutic drug level increased 10.37 10.09 12 501015 345 79243016
Osteomyelitis fungal 10.35 10.09 11 501016 287 79243074
Acute febrile neutrophilic dermatosis 10.35 10.09 50 500977 3822 79239539
Polymyalgia rheumatica 10.34 10.09 8 501019 4529 79238832
T-cell type acute leukaemia 10.33 10.09 9 501018 182 79243179
Concomitant disease aggravated 10.33 10.09 45 500982 13122 79230239
Hot flush 10.31 10.09 264 500763 54613 79188748
Human rhinovirus test positive 10.31 10.09 14 501013 475 79242886
Pustular psoriasis 10.30 10.09 9 501018 4797 79238564
Subarachnoid haemorrhage 10.30 10.09 101 500926 24364 79218997
Metastases to muscle 10.29 10.09 12 501015 348 79243013
Granulocytopenia 10.28 10.09 37 500990 11394 79231967
Tic 10.26 10.09 3 501024 2983 79240378
Complication associated with device 10.26 10.09 66 500961 17430 79225931
Cytomegalovirus hepatitis 10.25 10.09 18 501009 766 79242595
Pleural thickening 10.24 10.09 3 501024 2979 79240382
Myasthenia gravis crisis 10.24 10.09 22 501005 1089 79242272
Catheter placement 10.20 10.09 3 501024 2971 79240390
Priapism 10.20 10.09 8 501019 4497 79238864
Hepatotoxicity 10.18 10.09 407 500620 50945 79192416
Brain herniation 10.17 10.09 81 500946 7382 79235979
Oesophageal adenocarcinoma 10.17 10.09 19 501008 849 79242512
Fascial infection 10.17 10.09 3 501024 3 79243358
Electrophoresis protein abnormal 10.17 10.09 3 501024 3 79243358
Porocarcinoma 10.17 10.09 3 501024 3 79243358
Urinary bladder haematoma 10.17 10.09 4 501023 15 79243346
Eosinophilic pneumonia 10.16 10.09 11 501016 5299 79238062
Physical disability 10.14 10.09 4 501023 3294 79240067
Lymphoedema 10.14 10.09 121 500906 12292 79231069

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AC02 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Corticosteroids for local oral treatment
ATC C05AA09 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AB19 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC D07CB04 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, moderately potent, combinations with antibiotics
ATC D07XB05 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, moderately potent, other combinations
ATC D10AA03 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Corticosteroids, combinations for treatment of acne
ATC H02AB02 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD03 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R01AD53 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC S01BA01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01CA01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S01CB01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA06 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC S02CA06 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S03BA01 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS
Corticosteroids
ATC S03CA01 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000932 Antiemetics
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:37962 adrenergic agents
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Otitis externa indication 3135009
Keratitis indication 5888003 DOID:4677
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Cyclitis indication 17657000
Systemic AL amyloidosis indication 23132008
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Keloid scar indication 33659008
Crohn's disease indication 34000006
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Punctate keratitis indication 42513006 DOID:12197
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Lรถffler's syndrome indication 64936001 DOID:9503
Iritis indication 65074000 DOID:1406
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Blepharoconjunctivitis indication 68659002 DOID:2456
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Perforation of cornea indication 74895004
Iridocyclitis indication 77971008
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Corneal abrasion indication 85848002
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Corneal ulcer indication 91514001 DOID:8463
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Multiple myeloma indication 109989006 DOID:9538
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Mycosis fungoides indication 118618005
Uveitis indication 128473001 DOID:13141
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Central retinal vein occlusion with macular edema indication 232039004
Branch retinal vein occlusion with macular edema indication 232048009
Malignant otitis externa due to Pseudomonas aeruginosa indication 232230009
Scalp psoriasis indication 238608008
Punctate keratopathy indication 246936005
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Infective otitis media indication 312218008
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Herpes zoster keratitis indication 397573005
Rosacea indication 398909004 DOID:8881
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Allergic otitis externa indication 405821001
Anterior uveitis indication 410692006 DOID:1407
Autoimmune hemolytic anemia indication 413603009 DOID:718
Allergic conjunctivitis indication 473460002 DOID:11204
Otitis Externa Seborrhea indication
Non-infectious Posterior Uveitis indication
Transfusion Reaction Urticaria indication
Staphylococcus Aureus Otitis Externa indication
Tuberculosis Meningitis Treatment Adjunct indication
Synovitis due to Osteoarthritis indication
Otitis Externa Eczema indication
Diagnostic Test for Cushing's Syndrome indication
Erythroblastic Anemia indication
Post-Op Ocular Inflammation indication
Progressive Diffuse Large B-Cell Lymphoma indication
Systemic Dermatomyositis indication
Pericarditis off-label use 3238004 DOID:1787
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Tendinitis off-label use 34840004 DOID:971
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Croup off-label use 71186008 DOID:9395
Pemphigoid off-label use 86142006
Myasthenia gravis off-label use 91637004 DOID:437
Polyarteritis nodosa off-label use 155441006 DOID:9810
Chemotherapy-induced nausea and vomiting off-label use 236084000
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Metastatic Prostate Carcinoma off-label use
Prevention of Post-Operative Nausea and Vomiting off-label use
Prevention of Radiation-Induced Nausea and Vomiting off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Endophthalmitis contraindication 1847009 DOID:4692
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Herpes simplex keratitis contraindication 9389005
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Glaucoma contraindication 23986001 DOID:1686
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Severe myopia contraindication 34187009
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Retinal detachment contraindication 42059000 DOID:5327
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Ornithine Carbamyltransferase Deficiency contraindication 80908008 DOID:9271
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Bacterial infection of eye contraindication 128984004
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Injury of eye region contraindication 282752000
Varicella-zoster virus infection contraindication 309465005
Viral eye infection contraindication 312132001
Viral ear infection contraindication 312137007
Osteopenia contraindication 312894000
Vaccinia keratitis contraindication 397552005
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Arginosuccinate Lyase Deficiency contraindication




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Cats Inflammation Indication
Cattle Primary bovine ketosis Indication
Cattle Inflammation Indication
Dogs Inflammation Indication
Horses Inflammation Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Azium Tablets 0.25 mg Intervet Inc. 1
Azium Aqueous Suspension Veterinary Intervet Inc. 1
Azium Solution Intervet Inc. 1
Naquasone Bolus Intervet Inc. 2
Azium Powder Intervet Inc. 1
Azium Boluses 10 mg Intervet Inc. 1
Tresaderm Dermatologic Solution Boehringer lngelheim Animal Health USA Inc. 3
Azium Oral Solution 2 mg Intervet Inc. 1
Dexium Tablets Bimeda Animal Health Limited 1
Dexameth-A-Vet Injection Bimeda Animal Health Limited 1
Dexameth-A-Vet Bimeda Animal Health Limited 1
Pet Derm III Tablets Kinetic Technologies LLC 1
Dexamethasone Sterile Solution Kinetic Technologies LLC 1
Zonometh Solution Huvepharma EOOD 1
Dexachel Zoetis Inc. 1
Dexamethasone Solution Huvepharma EOOD 1
Dexium Bimeda Animal Health Limited 1
Dexamethasone Injection Sparhawk Laboratories Inc. 1
Dexamethasone Solution Med-Pharmex Inc. 1
Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Dechra Veterinary Products LLC 3

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 12.45 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.7MG OZURDEX ABBVIE N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 10702539 Jan. 9, 2023 TREATMENT OF DIABETIC MACULAR EDEMA
0.7MG OZURDEX ABBVIE N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 10702539 Jan. 9, 2023 TREATMENT OF MACULAR EDEMA FOLLOWING BRANCH RETINAL VEIN OCCLUSION (BRVO) OR CENTRAL RETINAL VEIN OCCLUSION (CRVO)
0.7MG OZURDEX ABBVIE N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 10702539 Jan. 9, 2023 TREATMENT OF NON-INFECTIOUS UVEITIS AFFECTING THE POSTERIOR SEGMENT OF THE EYE
0.7MG OZURDEX ABBVIE N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8034366 Jan. 9, 2023 TREATMENT OF MACULAR EDEMA
0.7MG OZURDEX ABBVIE N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8034366 Jan. 9, 2023 TREATMENT OF UVEITIS
0.7MG OZURDEX ABBVIE N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8506987 Jan. 9, 2023 TREATMENT OF MACULAR EDEMA
0.7MG OZURDEX ABBVIE N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8506987 Jan. 9, 2023 TREATMENT OF UVEITIS
0.7MG OZURDEX ABBVIE N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 6899717 Nov. 1, 2023 DELIVERING AN OCULAR IMPLANT AS DESCRIBED IN THE DOSAGE AND ADMINISTRATION SECTION OF THE APPROVED LABELING OF OZURDEX
0.3%;0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 8846650 June 4, 2025 TREATMENT OF ACUTE OTITIS MEDIA
0.05%;0.3% TOBRADEX ST EYEVANCE N050818 Feb. 13, 2009 RX SUSPENSION/DROPS OPHTHALMIC 8101582 Dec. 19, 2027 USE OF A COMBINATION OF TOBRAMYCIN AND DEXAMETHASONE TO TREAT OCULAR INFLAMMATION WHERE AN INFECTION OR RISK OF INFECTION EXISTS
0.05%;0.3% TOBRADEX ST EYEVANCE N050818 Feb. 13, 2009 RX SUSPENSION/DROPS OPHTHALMIC 7795316 Aug. 3, 2028 USE OF A COMBINATION OF TOBRAMYCIN AND DEXAMETHASONE TO TREAT OCULAR INFLAMMATION WHERE AN INFECTION OR RISK OF INFECTION EXISTS
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC 8563027 Feb. 12, 2030 DEXTENZA IS APPROVED FOR THE TREATMENT OF OCULAR PAIN FOLLOWING OPHTHALMIC SURGERY
9% DEXYCU KIT EYEPOINT PHARMS N208912 Feb. 9, 2018 RX SUSPENSION INTRAOCULAR 10028965 May 23, 2034 TREATMENT OF POSTOPERATIVE INFLAMMATION
9% DEXYCU KIT EYEPOINT PHARMS N208912 Feb. 9, 2018 RX SUSPENSION INTRAOCULAR 10022502 June 22, 2034 TREATMENT OF POSTOPERATIVE INFLAMMATION
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC 11458041 Nov. 16, 2037 TREATMENT OF OCULAR INFLAMMATION AND PAIN FOLLOWING OPHTHALMIC SURGERY
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC 11458041 Nov. 16, 2037 TREATMENT OF OCULAR ITCHING ASSOCIATED WITH ALLERGIC CONJUNCTIVITIS
20MG HEMADY DEXCEL N211379 Oct. 3, 2019 RX TABLET ORAL 11304961 Dec. 18, 2037 A METHOD OF TREATING ADULTS WITH MULTIPLE MYELOMA USING DEXAMETHASONE IN COMBINATION WITH AN ANTI-MYELOMA PRODUCT
9% DEXYCU KIT EYEPOINT PHARMS N208912 Feb. 9, 2018 RX SUSPENSION INTRAOCULAR 11097061 June 23, 2039 A METHOD OF LOADING MEDICATION INTO A SYRINGE AND DELIVERING THE MEDICATION TO A TREATMENT SITE

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2MG DEXAMETHASONE AMNEAL A216295 Sept. 8, 2022 RX TABLET ORAL March 8, 2023 COMPETITIVE GENERIC THERAPY
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC Oct. 7, 2024 TREATMENT OF OCULAR ITCHING ASSOCIATED WITH ALLERGIC CONJUNCTIVITIS
20MG HEMADY DEXCEL N211379 Oct. 3, 2019 RX TABLET ORAL Oct. 3, 2026 INDICATED IN COMBINATION WITH OTHER ANTI-MYELOMA PRODUCTS FOR THE TREATMENT OF ADULTS WITH MULTIPLE MYELOMA (MM)

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8.88 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK
Interleukin-5 Cytokine IC50 8.46 WOMBAT-PK
Mineralocorticoid receptor Nuclear hormone receptor EC50 9 WOMBAT-PK
Interleukin-4 Cytokine IC50 8.33 WOMBAT-PK
Androgen receptor Nuclear hormone receptor Ki 5.85 CHEMBL
Progesterone receptor Nuclear hormone receptor Ki 6.25 CHEMBL
Prostaglandin G/H synthase 2 Enzyme Ki 6.89 PDSP
Androgen receptor Transcription factor Ki 4.79 DRUG MATRIX
Fatty acid-binding protein, liver Unclassified Ki 4.66 CHEMBL
Progesterone receptor Transcription factor Ki 5.52 DRUG MATRIX
Glucocorticoid receptor Transcription factor IC50 7.66 CHEMBL
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor AGONIST EC50 6.10 IUPHAR

External reference:

IDSource
4017922 VUID
N0000146273 NUI
D00292 KEGG_DRUG
203704 RXNORM
4017922 VANDF
C0011777 UMLSCUI
CHEBI:41879 CHEBI
DEX PDB_CHEM_ID
CHEMBL384467 ChEMBL_ID
CHEMBL2021430 ChEMBL_ID
CHEMBL1200637 ChEMBL_ID
DB01234 DRUGBANK_ID
D003907 MESH_DESCRIPTOR_UI
5743 PUBCHEM_CID
2768 IUPHAR_LIGAND_ID
816 INN_ID
7S5I7G3JQL UNII
4552 MMSL
6848 MMSL
6849 MMSL
d00206 MMSL
002174 NDDF
372584003 SNOMEDCT_US
7561000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
OZURDEX HUMAN PRESCRIPTION DRUG LABEL 1 0023-3348 IMPLANT 0.70 mg INTRAVITREAL NDA 24 sections
OZURDEX HUMAN PRESCRIPTION DRUG LABEL 1 0023-3348 IMPLANT 0.70 mg INTRAVITREAL NDA 24 sections
Dexamethasone Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3176 SOLUTION, CONCENTRATE 1 mg ORAL ANDA 20 sections
Dexamethasone Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3176 SOLUTION, CONCENTRATE 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-3177 SOLUTION 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-3177 SOLUTION 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4179 TABLET 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4179 TABLET 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4180 TABLET 0.75 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4180 TABLET 0.75 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4181 TABLET 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4181 TABLET 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4182 TABLET 1.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4182 TABLET 1.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4183 TABLET 2 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4183 TABLET 2 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4184 TABLET 4 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4184 TABLET 4 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4186 TABLET 6 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4186 TABLET 6 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8174 TABLET 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8174 TABLET 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8175 TABLET 4 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8175 TABLET 4 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8176 TABLET 2 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8176 TABLET 2 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8179 TABLET 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8179 TABLET 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8180 TABLET 0.75 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8180 TABLET 0.75 mg ORAL ANDA 20 sections