dexamethasone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 824 50-02-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexamethasone
  • dexasone
  • dexmethsone
An anti-inflammatory 9-fluoro-glucocorticoid. The NIH COVID-19 Treatment Guidelines Panel recommends the use of dexamethasone in patients with COVID-19 who are receiving mechanical ventilation or in those who require supplemental oxygen but are not on me-chanical ventilation. It is not recommended the use of dexamethasone or other corticosteroids in nonhospitalized patients with mild to moderate COVID-19 or in hospitalized patients with COVID-19 who do not require supplemental oxygen.
  • Molecular weight: 392.47
  • Formula: C22H29FO5
  • CLOGP: 1.78
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.89
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 mg O
1.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.09 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2.60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.33 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.94 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.32 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 30, 1958 FDA
Aug. 25, 2021 PMDA NICHI - IKO PHARMACEUTICAL Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 2457.25 10.29 1732 273906 29590 50299896
Neuropathy peripheral 1762.65 10.29 2394 273244 94363 50235123
Neutropenia 1632.41 10.29 2904 272734 145061 50184425
Febrile neutropenia 1367.11 10.29 2134 273504 95533 50233953
Thrombocytopenia 1243.87 10.29 2376 273262 125297 50204189
Diarrhoea 847.15 10.29 5783 269855 582693 49746793
Rheumatoid arthritis 777.15 10.29 95 275543 202455 50127031
Drug ineffective 763.59 10.29 2135 273503 817198 49512288
Pneumonia 659.00 10.29 3907 271731 374494 49954992
Completed suicide 658.18 10.29 12 275626 131877 50197609
Platelet count decreased 593.66 10.29 1534 274104 99192 50230294
Constipation 579.31 10.29 2270 273368 183438 50146048
Systemic lupus erythematosus 539.04 10.29 66 275572 140556 50188930
Death 535.56 10.29 3312 272326 322067 50007419
Disease progression 530.27 10.29 1426 274212 94440 50235046
White blood cell count decreased 506.75 10.29 1592 274046 115130 50214356
Plasma cell myeloma recurrent 505.49 10.29 260 275378 2398 50327088
Contraindicated product administered 496.67 10.29 103 275535 148855 50180631
Pemphigus 479.18 10.29 49 275589 120117 50209369
Full blood count decreased 476.09 10.29 598 275040 21748 50307738
Neutrophil count decreased 475.16 10.29 879 274759 45147 50284339
Anaemia 418.10 10.29 2575 273063 249881 50079605
Pain 417.50 10.29 1683 273955 577220 49752266
Pancytopenia 417.28 10.29 1202 274436 82828 50246658
Arthralgia 407.22 10.29 1142 274496 437560 49891926
Therapeutic product effect decreased 396.05 10.29 124 275514 135926 50193560
Drug hypersensitivity 395.74 10.29 471 275167 250539 50078947
Hand deformity 379.11 10.29 49 275589 100150 50229336
Sepsis 368.19 10.29 1567 274071 131358 50198128
Condition aggravated 357.17 10.29 672 274966 296386 50033100
Injection site pain 351.48 10.29 86 275552 110938 50218548
Synovitis 337.80 10.29 126 275512 123739 50205747
Thrombosis 335.55 10.29 857 274781 54976 50274510
Deep vein thrombosis 332.89 10.29 1016 274622 72288 50257198
Arthropathy 332.77 10.29 226 275412 157680 50171806
Mucosal inflammation 328.95 10.29 696 274942 39446 50290040
Plasmacytoma 324.75 10.29 187 275451 2198 50327288
Leukopenia 319.87 10.29 950 274688 66578 50262908
Abdominal discomfort 315.07 10.29 484 275154 231157 50098329
Glossodynia 312.73 10.29 119 275519 115450 50214036
Intentional overdose 291.89 10.29 11 275627 62493 50266993
Unevaluable event 286.08 10.29 716 274922 45350 50284136
Neutropenic sepsis 278.36 10.29 364 275274 13783 50315703
Joint swelling 268.94 10.29 585 275053 244701 50084785
Anti-cyclic citrullinated peptide antibody positive 261.08 10.29 37 275601 70550 50258936
Swelling 253.18 10.29 441 275197 200431 50129055
Cytopenia 248.86 10.29 272 275366 8503 50320983
Pulmonary embolism 248.26 10.29 1155 274483 100549 50228937
Laboratory test abnormal 245.44 10.29 448 275190 22760 50306726
Pericarditis 245.05 10.29 63 275575 78626 50250860
Psoriasis 244.20 10.29 41 275597 68959 50260527
Febrile bone marrow aplasia 232.16 10.29 225 275413 6086 50323400
Overdose 229.05 10.29 129 275509 99598 50229888
Wound 228.76 10.29 147 275491 105647 50223839
Drug abuse 219.85 10.29 32 275606 59814 50269672
Septic shock 215.70 10.29 744 274894 56431 50273055
Tumour lysis syndrome 215.63 10.29 233 275405 7188 50322298
Musculoskeletal stiffness 209.86 10.29 234 275404 128247 50201239
Treatment failure 209.53 10.29 265 275373 137372 50192114
Headache 209.16 10.29 1761 273877 504774 49824712
Drug intolerance 202.93 10.29 570 275068 218534 50110952
Suicide attempt 198.78 10.29 24 275614 51708 50277778
Discomfort 198.04 10.29 179 275459 108201 50221285
Peripheral sensory neuropathy 196.89 10.29 210 275428 6381 50323105
Injection site erythema 194.75 10.29 82 275556 74854 50254632
Pyrexia 193.44 10.29 3024 272614 377179 49952307
Hepatic enzyme increased 191.48 10.29 282 275356 137098 50192388
Polyneuropathy 190.48 10.29 280 275358 11851 50317635
Fatigue 184.60 10.29 5097 270541 702504 49626982
Maternal exposure during pregnancy 184.27 10.29 370 275268 159408 50170078
Malignant neoplasm progression 180.63 10.29 793 274845 67331 50262155
Rheumatoid factor positive 177.81 10.29 29 275609 49830 50279656
Asthenia 172.33 10.29 2564 273074 316478 50013008
Plasma cell leukaemia 166.63 10.29 90 275548 925 50328561
Psoriatic arthropathy 161.93 10.29 30 275608 47002 50282484
Abortion spontaneous 156.57 10.29 21 275617 41751 50287735
Posterior reversible encephalopathy syndrome 156.35 10.29 287 275351 14641 50314845
Loss of personal independence in daily activities 156.01 10.29 94 275544 69956 50259530
Dehydration 154.99 10.29 1386 274252 151063 50178423
Muscle injury 153.53 10.29 13 275625 37098 50292388
Multiple sclerosis relapse 153.18 10.29 25 275613 42939 50286547
Injection site reaction 152.07 10.29 42 275596 49990 50279496
Knee arthroplasty 149.84 10.29 12 275626 35834 50293652
Bone marrow failure 146.60 10.29 405 275233 27219 50302267
Helicobacter infection 143.28 10.29 46 275592 49656 50279830
Mobility decreased 137.89 10.29 139 275499 79809 50249677
Off label use 137.81 10.29 3468 272170 470958 49858528
Irritable bowel syndrome 134.12 10.29 56 275582 51385 50278101
Sleep disorder due to general medical condition, insomnia type 132.93 10.29 10 275628 31437 50298049
Flushing 132.31 10.29 717 274921 66298 50263188
Injection site pruritus 130.39 10.29 30 275608 40381 50289105
Light chain analysis increased 128.31 10.29 78 275560 1020 50328466
Osteonecrosis 127.38 10.29 338 275300 22179 50307307
Inappropriate schedule of product administration 127.21 10.29 122 275516 71709 50257777
Injection site swelling 127.08 10.29 35 275603 41738 50287748
Folliculitis 126.80 10.29 29 275609 39196 50290290
Therapeutic product effect incomplete 126.35 10.29 189 275449 91326 50238160
Bone pain 125.34 10.29 550 275088 46679 50282807
Suicidal ideation 125.19 10.29 73 275565 55312 50274174
Osteoarthritis 124.47 10.29 114 275524 68492 50260994
Venoocclusive liver disease 124.17 10.29 134 275504 4127 50325359
Injection site bruising 123.31 10.29 25 275613 36743 50292743
Duodenal ulcer perforation 123.25 10.29 47 275591 45564 50283922
Monoclonal immunoglobulin present 119.77 10.29 65 275573 675 50328811
Depression 117.19 10.29 483 275155 164940 50164546
Impaired healing 115.10 10.29 126 275512 69660 50259826
Wrong technique in product usage process 114.75 10.29 81 275557 55429 50274057
Pneumocystis jirovecii pneumonia 114.05 10.29 249 275389 14414 50315072
COVID-19 pneumonia 113.78 10.29 181 275457 8214 50321272
Haematotoxicity 113.65 10.29 175 275463 7720 50321766
Metastases to central nervous system 113.26 10.29 213 275425 11069 50318417
Endophthalmitis 113.01 10.29 107 275531 2809 50326677
Decreased appetite 112.28 10.29 1625 274013 199298 50130188
Migraine 111.35 10.29 148 275490 75132 50254354
Intentional self-injury 108.12 10.29 4 275634 23108 50306378
C-reactive protein abnormal 106.59 10.29 13 275625 27796 50301690
Sinusitis 106.40 10.29 522 275116 170036 50159450
Intentional product misuse 105.05 10.29 62 275576 46672 50282814
Neurotoxicity 104.24 10.29 241 275397 14499 50314987
Haemophagocytic lymphohistiocytosis 103.35 10.29 176 275462 8457 50321029
Hip arthroplasty 101.40 10.29 21 275617 30408 50299078
Stress 98.03 10.29 89 275549 53704 50275782
Hospitalisation 98.01 10.29 136 275502 67801 50261685
Hyperglycaemia 97.38 10.29 425 275213 35980 50293506
Myelodysplastic syndrome 94.73 10.29 236 275402 14896 50314590
Asthma 94.50 10.29 217 275421 89120 50240366
Acute lymphocytic leukaemia recurrent 93.29 10.29 81 275557 1894 50327592
Dysgeusia 91.23 10.29 437 275201 38479 50291007
Blood potassium decreased 91.09 10.29 421 275217 36524 50292962
Ill-defined disorder 90.88 10.29 98 275540 54556 50274930
Ageusia 90.43 10.29 197 275441 11386 50318100
COVID-19 89.23 10.29 495 275143 46167 50283319
Pneumonitis 88.68 10.29 357 275281 29153 50300333
Alopecia 87.28 10.29 883 274755 244164 50085322
Cardiac amyloidosis 85.60 10.29 52 275586 679 50328807
Blister 85.18 10.29 214 275424 85204 50244282
Drug withdrawal syndrome 84.21 10.29 17 275621 25064 50304422
Therapy partial responder 83.74 10.29 138 275500 6453 50323033
Pain in extremity 83.42 10.29 1018 274620 271847 50057639
Drug interaction 83.35 10.29 691 274947 198930 50130556
Hypokalaemia 81.77 10.29 785 274853 87207 50242279
Multiple organ dysfunction syndrome 81.43 10.29 511 275127 49826 50279660
Arthritis 79.12 10.29 227 275411 86494 50242992
Surgery 76.95 10.29 34 275604 30171 50299315
Corneal oedema 76.07 10.29 62 275576 1325 50328161
Haemoglobin decreased 74.22 10.29 1037 274601 126179 50203307
Back pain 73.85 10.29 1642 273996 218388 50111098
Osteolysis 73.79 10.29 80 275558 2477 50327009
Red blood cell sedimentation rate increased 73.55 10.29 34 275604 29382 50300104
Cytokine release syndrome 73.37 10.29 152 275486 8482 50321004
Accidental exposure to product 72.64 10.29 18 275620 23039 50306447
Injury 71.51 10.29 97 275541 48828 50280658
Taste disorder 71.27 10.29 147 275491 8177 50321309
Erythema 70.89 10.29 1156 274482 145258 50184228
Myocardial infarction 70.05 10.29 249 275389 88778 50240708
Gait disturbance 69.74 10.29 504 275134 149501 50179985
Anaphylactic shock 69.73 10.29 255 275383 19900 50309586
Diffuse large B-cell lymphoma recurrent 68.54 10.29 62 275576 1533 50327953
Corneal decompensation 68.28 10.29 20 275618 25 50329461
Pregnancy 68.24 10.29 38 275600 29539 50299947
Fall 66.74 10.29 1355 274283 333577 49995909
Palmar-plantar erythrodysaesthesia syndrome 65.96 10.29 250 275388 19848 50309638
Incorrect dose administered 65.82 10.29 101 275537 48313 50281173
Sleep apnoea syndrome 65.48 10.29 24 275614 23844 50305642
Hypoglycaemia 65.25 10.29 120 275518 53461 50276025
Respiratory syncytial virus infection 65.05 10.29 107 275531 4995 50324491
Pulmonary thrombosis 63.19 10.29 132 275506 7409 50322077
Injection site haemorrhage 62.87 10.29 19 275619 21327 50308159
Hypoxia 62.65 10.29 485 275153 50638 50278848
Fibromyalgia 61.95 10.29 93 275545 44885 50284601
Coronary artery disease 61.93 10.29 43 275595 29683 50299803
Product use issue 60.74 10.29 521 275117 148954 50180532
Large intestine perforation 60.27 10.29 129 275509 7365 50322121
Clostridium difficile colitis 59.31 10.29 222 275416 17520 50311966
Coma 58.66 10.29 140 275498 56739 50272747
Nausea 58.56 10.29 4527 271111 700871 49628615
Muscle spasms 58.07 10.29 984 274654 124569 50204917
Hepatitis B reactivation 57.97 10.29 64 275574 2023 50327463
Blood pressure fluctuation 57.61 10.29 66 275572 35757 50293729
Bronchospasm 57.47 10.29 195 275443 14659 50314827
Muscle spasticity 56.96 10.29 12 275626 17172 50312314
Cytomegalovirus infection 56.95 10.29 221 275417 17741 50311745
Protein total increased 56.68 10.29 69 275569 2427 50327059
Ejection fraction decreased 56.40 10.29 225 275413 18295 50311191
Product quality issue 56.28 10.29 51 275587 30807 50298679
Aplasia 55.56 10.29 85 275553 3728 50325758
Joint range of motion decreased 55.39 10.29 16 275622 18496 50310990
Pneumonia influenzal 55.27 10.29 53 275585 1414 50328072
Respiratory failure 54.27 10.29 746 274892 90435 50239051
Acute lymphocytic leukaemia 54.25 10.29 64 275574 2177 50327309
Intentional product use issue 54.15 10.29 225 275413 76693 50252793
Weight increased 54.04 10.29 774 274864 201117 50128369
Product use in unapproved indication 54.03 10.29 909 274729 114910 50214576
Myelosuppression 53.67 10.29 179 275459 13338 50316148
Pathological fracture 53.66 10.29 125 275513 7557 50321929
Foot deformity 53.23 10.29 19 275619 19191 50310295
Multiple sclerosis 52.31 10.29 23 275615 20470 50309016
Exposure during pregnancy 52.25 10.29 415 275223 120600 50208886
Cytomegalovirus infection reactivation 52.22 10.29 68 275570 2563 50326923
Herpes simplex encephalitis 52.15 10.29 28 275610 284 50329202
Blood pressure systolic increased 52.09 10.29 70 275568 35379 50294107
Colitis 52.01 10.29 374 275264 38155 50291331
Bacteraemia 51.96 10.29 185 275453 14248 50315238
Osteoporosis 51.61 10.29 104 275534 44775 50284711
Laryngospasm 51.07 10.29 68 275570 2620 50326866
Cataract 51.07 10.29 436 275202 46864 50282622
Dry skin 50.86 10.29 406 275232 42785 50286701
Impaired work ability 50.77 10.29 7 275631 13633 50315853
Substance-induced psychotic disorder 50.50 10.29 53 275585 1580 50327906
Lymphopenia 50.18 10.29 193 275445 15428 50314058
Device issue 50.06 10.29 23 275615 19949 50309537
Injection site warmth 49.57 10.29 8 275630 13858 50315628
Hypofibrinogenaemia 49.31 10.29 44 275594 1068 50328418
Obesity 49.28 10.29 15 275623 16760 50312726
Dyspnoea 48.97 10.29 3536 272102 544072 49785414
Hyperviscosity syndrome 48.87 10.29 22 275616 146 50329340
Multiple allergies 48.83 10.29 128 275510 8335 50321151
Escherichia bacteraemia 47.59 10.29 71 275567 3045 50326441
Adverse drug reaction 47.56 10.29 485 275153 54737 50274749
Product complaint 47.47 10.29 4 275634 11462 50318024
Poisoning 47.17 10.29 6 275632 12423 50317063
Lactic acidosis 46.88 10.29 68 275570 33287 50296199
Paraesthesia 46.69 10.29 917 274721 119326 50210160
Sopor 46.65 10.29 25 275613 19854 50309632
Brain oedema 46.64 10.29 161 275477 12209 50317277
Injection site urticaria 46.11 10.29 6 275632 12211 50317275
Contusion 46.01 10.29 390 275248 111793 50217693
Bone erosion 45.94 10.29 5 275633 11682 50317804
Mucormycosis 45.93 10.29 62 275576 2421 50327065
Hypertriglyceridaemia 45.87 10.29 96 275542 5395 50324091
Pulmonary arterial hypertension 45.60 10.29 27 275611 20292 50309194
Sedation 45.43 10.29 60 275578 30550 50298936
Febrile infection 45.03 10.29 43 275595 1141 50328345
Bronchopulmonary aspergillosis 45.01 10.29 116 275522 7476 50322010
Neutrophil count abnormal 44.88 10.29 61 275577 2398 50327088
Injection site rash 44.83 10.29 16 275622 16161 50313325
Feeling hot 44.26 10.29 365 275273 38837 50290649
Product substitution issue 44.23 10.29 11 275627 14046 50315440
Chronic obstructive pulmonary disease 43.68 10.29 147 275491 53288 50276198
Bursitis 43.54 10.29 34 275604 22101 50307385
Joint stiffness 43.37 10.29 61 275577 30247 50299239
Systemic candida 43.22 10.29 64 275574 2726 50326760
Brain abscess 43.11 10.29 51 275587 1740 50327746
International normalised ratio increased 43.09 10.29 108 275530 43044 50286442
Carpal tunnel syndrome 43.05 10.29 19 275619 16874 50312612
Withdrawal syndrome 42.95 10.29 21 275617 17569 50311917
Embolism 42.91 10.29 108 275530 6860 50322626
Bone lesion 42.74 10.29 90 275548 5080 50324406
Injection site mass 42.62 10.29 16 275622 15664 50313822
Brain stem glioma 42.47 10.29 19 275619 124 50329362
Neutropenic infection 42.34 10.29 40 275598 1047 50328439
Aspergillus infection 42.29 10.29 106 275532 6715 50322771
Strongyloidiasis 42.14 10.29 36 275602 823 50328663
Vomiting 42.13 10.29 2981 272657 457777 49871709
Sleep disorder 41.93 10.29 165 275473 57118 50272368
Right ventricular failure 41.90 10.29 17 275621 15876 50313610
Peripheral motor neuropathy 41.69 10.29 45 275593 1386 50328100
Human chorionic gonadotropin increased 41.20 10.29 42 275596 1209 50328277
Influenza like illness 41.11 10.29 167 275471 57292 50272194
Blood pressure diastolic decreased 41.02 10.29 20 275618 16761 50312725
Renal failure 40.99 10.29 812 274826 105821 50223665
Body height decreased 40.88 10.29 124 275514 8784 50320702
Full blood count increased 40.82 10.29 36 275602 860 50328626
Inflammation 40.35 10.29 166 275472 56746 50272740
Cardiotoxicity 40.26 10.29 106 275532 6921 50322565
Intestinal perforation 40.04 10.29 137 275501 10342 50319144
Venous thrombosis 39.57 10.29 80 275558 4386 50325100
Hypocalcaemia 39.55 10.29 266 275372 26550 50302936
Atrial fibrillation 39.52 10.29 776 274862 100969 50228517
Rhabdomyolysis 39.49 10.29 97 275541 38930 50290556
Squamous cell carcinoma of skin 39.21 10.29 87 275551 5091 50324395
Somnolence 39.09 10.29 601 275037 154384 50175102
Medication error 38.72 10.29 87 275551 36017 50293469
Tooth disorder 38.57 10.29 245 275393 23983 50305503
Lacrimation increased 38.51 10.29 189 275449 16803 50312683
Rhinovirus infection 38.34 10.29 69 275569 3465 50326021
Iron deficiency anaemia 38.30 10.29 22 275616 16812 50312674
Anxiety 37.88 10.29 710 274928 176896 50152590
Device breakage 37.75 10.29 4 275634 9543 50319943
Palpitations 37.66 10.29 331 275307 94175 50235311
Type 2 diabetes mellitus 37.55 10.29 82 275556 34293 50295193
Lupus-like syndrome 37.46 10.29 4 275634 9487 50319999
Wheezing 37.44 10.29 192 275446 61855 50267631
Hypercholesterolaemia 37.13 10.29 9 275629 11694 50317792
Colitis ulcerative 36.98 10.29 23 275615 16831 50312655
Nephrolithiasis 36.88 10.29 84 275554 34609 50294877
Blood pressure diastolic abnormal 36.81 10.29 4 275634 9357 50320129
Breast cancer metastatic 36.59 10.29 132 275506 10232 50319254
Hyperbilirubinaemia 36.47 10.29 125 275513 9445 50320041
Treatment noncompliance 36.28 10.29 68 275570 30082 50299404
Hypercalcaemia 35.86 10.29 234 275404 23118 50306368
Product storage error 35.78 10.29 11 275627 12213 50317273
Disseminated intravascular coagulation 35.61 10.29 186 275452 16949 50312537
Blood pressure increased 35.38 10.29 511 275127 132621 50196865
Underdose 35.24 10.29 35 275603 20243 50309243
Myalgia 34.87 10.29 472 275166 123847 50205639
Crying 34.61 10.29 36 275602 20380 50309106
Acute interstitial pneumonitis 34.49 10.29 28 275610 595 50328891
Device malfunction 34.06 10.29 20 275618 15101 50314385
Seasonal allergy 33.80 10.29 164 275474 14512 50314974
Light chain analysis abnormal 33.57 10.29 16 275622 123 50329363
No adverse event 33.55 10.29 84 275554 33494 50295992
Chorioretinopathy 33.33 10.29 31 275607 795 50328691
Nasal congestion 33.26 10.29 154 275484 50966 50278520
Pneumonia fungal 33.18 10.29 73 275565 4247 50325239
Salmonella sepsis 33.16 10.29 19 275619 221 50329265
Performance status decreased 32.92 10.29 61 275577 3134 50326352
Refractory cytopenia with multilineage dysplasia 32.62 10.29 16 275622 132 50329354
Neuroleptic malignant syndrome 32.61 10.29 10 275628 11120 50318366
Jugular vein thrombosis 32.32 10.29 55 275583 2641 50326845
Human bocavirus infection 32.28 10.29 22 275616 354 50329132
Product prescribing error 32.23 10.29 40 275598 20921 50308565
Pneumonia cytomegaloviral 32.21 10.29 46 275592 1895 50327591
Radiation skin injury 32.18 10.29 31 275607 832 50328654
Pseudomonal sepsis 32.16 10.29 48 275590 2059 50327427
Neoplasm progression 32.12 10.29 270 275368 28887 50300599
Infective pulmonary exacerbation of cystic fibrosis 32.09 10.29 3 275635 7906 50321580
Blood lactate dehydrogenase abnormal 32.05 10.29 18 275620 201 50329285
Pleural effusion 31.88 10.29 622 275016 80832 50248654
Parkinsonism 31.86 10.29 5 275633 8842 50320644
Glioblastoma 31.60 10.29 29 275609 731 50328755
Hypersensitivity 31.36 10.29 912 274726 214249 50115237
Skin discolouration 31.28 10.29 294 275344 32463 50297023
Gastrointestinal perforation 30.98 10.29 58 275580 3003 50326483
Musculoskeletal pain 30.91 10.29 248 275390 71929 50257557
Poor venous access 30.82 10.29 9 275629 10331 50319155
Prescribed underdose 30.74 10.29 25 275613 15924 50313562
Adrenogenital syndrome 30.62 10.29 11 275627 36 50329450
Therapeutic response unexpected 30.61 10.29 25 275613 15890 50313596
Parainfluenzae virus infection 30.48 10.29 44 275594 1831 50327655
Candida infection 30.40 10.29 226 275412 23297 50306189
Coombs indirect test positive 30.40 10.29 11 275627 37 50329449
Respiratory tract infection 30.39 10.29 287 275351 31730 50297756
Intraocular pressure increased 30.38 10.29 82 275556 5434 50324052
Pneumonia pneumococcal 30.33 10.29 42 275596 1681 50327805
Foot fracture 30.20 10.29 39 275599 20052 50309434
Oral candidiasis 30.06 10.29 176 275462 16739 50312747
Clostridium difficile infection 29.87 10.29 239 275399 25200 50304286
Cholecystectomy 29.82 10.29 7 275631 9296 50320190
Alopecia areata 29.75 10.29 37 275601 1331 50328155
Labelled drug-drug interaction medication error 29.65 10.29 10 275628 10467 50319019
Joint effusion 29.65 10.29 17 275621 13004 50316482
Computerised tomogram thorax abnormal 29.43 10.29 37 275601 1346 50328140
Pneumatosis intestinalis 29.41 10.29 46 275592 2057 50327429
Epistaxis 29.09 10.29 500 275138 63454 50266032
White blood cell count abnormal 29.09 10.29 80 275558 5360 50324126
Diffuse large B-cell lymphoma refractory 28.92 10.29 32 275606 1014 50328472
Blood culture positive 28.89 10.29 69 275569 4239 50325247
Hyperaemia 28.89 10.29 45 275593 2005 50327481
Body dysmorphic disorder 28.86 10.29 18 275620 247 50329239
Spinal cord compression 28.86 10.29 63 275575 3646 50325840
Perineal necrosis 28.80 10.29 14 275624 113 50329373
Amyloidosis 28.79 10.29 31 275607 952 50328534
Hypopyon 28.74 10.29 26 275612 643 50328843
Gastrointestinal fungal infection 28.68 10.29 18 275620 250 50329236
Red blood cell count decreased 28.57 10.29 296 275342 33539 50295947
Enthesopathy 28.47 10.29 3 275635 7190 50322296
Ileus 28.46 10.29 145 275493 13084 50316402
Stridor 28.36 10.29 57 275581 3112 50326374
Heart block congenital 28.24 10.29 8 275630 8 50329478
Osteonecrosis of jaw 28.16 10.29 286 275352 32240 50297246
Panniculitis 28.06 10.29 6 275632 8497 50320989
Tremor 28.02 10.29 822 274816 114081 50215405
Product dispensing error 27.89 10.29 7 275631 8884 50320602
Nasopharyngitis 27.79 10.29 819 274819 192108 50137378
Perineal infection 27.79 10.29 14 275624 123 50329363
Hypogammaglobulinaemia 27.74 10.29 81 275557 5618 50323868
Propofol infusion syndrome 27.59 10.29 27 275611 739 50328747
Grip strength decreased 27.35 10.29 16 275622 12105 50317381
Respiratory distress 27.31 10.29 270 275368 30219 50299267
Sedation complication 27.31 10.29 7 275631 8759 50320727
Mitochondrial DNA mutation 27.28 10.29 17 275621 233 50329253
Hiatus hernia 27.18 10.29 36 275602 18308 50311178
Disease recurrence 27.14 10.29 195 275443 19886 50309600
Paraproteinaemia 26.98 10.29 15 275623 164 50329322
Glycosylated haemoglobin increased 26.91 10.29 12 275626 10594 50318892
Hordeolum 26.89 10.29 47 275591 2306 50327180
Swollen joint count increased 26.62 10.29 25 275613 14848 50314638
Pseudocellulitis 26.48 10.29 8 275630 12 50329474
Central nervous system leukaemia 26.42 10.29 13 275625 108 50329378
Blood pressure systolic abnormal 26.34 10.29 5 275633 7701 50321785
Accidental overdose 26.31 10.29 41 275597 19492 50309994
Depressed mood 26.19 10.29 96 275542 33927 50295559
Enterocolitis 26.10 10.29 87 275551 6480 50323006
Cardiopulmonary failure 25.91 10.29 57 275581 3316 50326170
Keratitis fungal 25.77 10.29 12 275626 87 50329399
Eczema 25.76 10.29 53 275585 22649 50306837
Haemoglobin abnormal 25.73 10.29 67 275571 4345 50325141
Electrolyte imbalance 25.73 10.29 171 275467 16998 50312488
Ulcer 25.71 10.29 44 275594 20156 50309330
Ovarian cyst 25.68 10.29 23 275615 13973 50315513
Hepatic cirrhosis 25.53 10.29 35 275603 17542 50311944
Vitreous haemorrhage 25.52 10.29 39 275599 1709 50327777
Fear 25.41 10.29 25 275613 14524 50314962
Neoplasm recurrence 25.38 10.29 46 275592 2323 50327163
Eosinophilia 25.26 10.29 39 275599 18613 50310873
Platelet count abnormal 25.20 10.29 51 275587 2798 50326688
Vasogenic cerebral oedema 25.10 10.29 21 275617 466 50329020
Rheumatic fever 25.09 10.29 33 275605 16834 50312652
Cholelithiasis 24.94 10.29 114 275524 37859 50291627
Crossmatch incompatible 24.93 10.29 9 275629 30 50329456
Fusarium infection 24.86 10.29 22 275616 528 50328958
Neutropenic colitis 24.72 10.29 46 275592 2371 50327115
Heavy menstrual bleeding 24.58 10.29 29 275609 15508 50313978
Extrapyramidal disorder 24.55 10.29 17 275621 11753 50317733
Adrenal insufficiency 24.54 10.29 147 275491 14096 50315390
Urticaria 24.30 10.29 529 275109 129032 50200454
Tardive dyskinesia 24.30 10.29 5 275633 7274 50322212
Escherichia test positive 23.97 10.29 42 275596 2065 50327421
Spinal fracture 23.88 10.29 156 275482 15417 50314069
Antithrombin III decreased 23.61 10.29 15 275623 213 50329273
Premature baby 23.60 10.29 176 275462 18161 50311325
Nocardiosis 23.55 10.29 37 275601 1661 50327825
Corneal opacity 23.46 10.29 23 275615 631 50328855
Pre-existing condition improved 23.43 10.29 5 275633 7092 50322394
Mesenteric abscess 23.37 10.29 11 275627 82 50329404
Hypertransaminasaemia 23.32 10.29 57 275581 3554 50325932
Bacterial sepsis 23.31 10.29 57 275581 3555 50325931
Hysterectomy 23.28 10.29 7 275631 7883 50321603
Immune effector cell-associated neurotoxicity syndrome 23.26 10.29 30 275608 1120 50328366
Pseudomonas test positive 23.17 10.29 23 275615 641 50328845
Bone density decreased 23.09 10.29 16 275622 11059 50318427
Product packaging confusion 23.00 10.29 13 275625 147 50329339
Pulmonary fibrosis 22.99 10.29 63 275575 24374 50305112
Depressed level of consciousness 22.95 10.29 177 275461 51776 50277710
Sternal fracture 22.89 10.29 40 275598 1962 50327524
Protein urine 22.85 10.29 22 275616 590 50328896
Exostosis 22.79 10.29 18 275620 11635 50317851
Hypoaesthesia 22.77 10.29 878 274760 126379 50203107
Road traffic accident 22.75 10.29 63 275575 24289 50305197
Lower respiratory tract infection 22.70 10.29 373 275265 94828 50234658
Recall phenomenon 22.70 10.29 21 275617 535 50328951
Blood immunoglobulin G increased 22.69 10.29 32 275606 1303 50328183
Hypothyroidism 22.68 10.29 102 275536 34023 50295463
Shock 22.63 10.29 191 275447 20459 50309027
Cryptococcosis 22.57 10.29 26 275612 862 50328624
Tendonitis 22.56 10.29 35 275603 16670 50312816
Primary amyloidosis 22.55 10.29 8 275630 25 50329461
Cytomegalovirus chorioretinitis 22.53 10.29 34 275604 1473 50328013
Klebsiella bacteraemia 22.28 10.29 31 275607 1246 50328240
Superficial spreading melanoma stage unspecified 22.24 10.29 12 275626 123 50329363
Large intestinal ulcer perforation 22.14 10.29 10 275628 67 50329419
Panic attack 22.08 10.29 45 275593 19297 50310189
Drug level increased 21.85 10.29 45 275593 19223 50310263
Hallucination, auditory 21.71 10.29 16 275622 10712 50318774
Leukoencephalopathy 21.66 10.29 58 275580 3825 50325661
Antinuclear antibody positive 21.59 10.29 4 275634 6268 50323218
Gastrointestinal disorder 21.57 10.29 373 275265 94083 50235403
Spinal operation 21.53 10.29 4 275634 6256 50323230
Pulmonary haemorrhage 21.50 10.29 81 275557 6411 50323075
Malignant neoplasm of unknown primary site 21.46 10.29 15 275623 252 50329234
Autonomic neuropathy 21.39 10.29 27 275611 986 50328500
Acute myeloid leukaemia 21.32 10.29 148 275490 14926 50314560
Ocular hypertension 21.31 10.29 24 275614 776 50328710
Nasal abscess 21.29 10.29 12 275626 135 50329351
Prescribed overdose 21.27 10.29 29 275609 14571 50314915
Phaeochromocytoma crisis 21.21 10.29 14 275624 213 50329273
Pupillary deformity 21.09 10.29 5 275633 0 50329486
Peripheral sensorimotor neuropathy 21.08 10.29 30 275608 1232 50328254
Blood magnesium decreased 21.06 10.29 118 275520 11042 50318444
Lung infiltration 21.05 10.29 135 275503 13258 50316228
Clostridium bacteraemia 20.87 10.29 13 275625 178 50329308
Vascular pain 20.82 10.29 22 275616 661 50328825
Gastrooesophageal reflux disease 20.77 10.29 292 275346 76136 50253350
Ascites 20.75 10.29 292 275346 35569 50293917
Procedural pain 20.64 10.29 27 275611 13805 50315681
Joint dislocation 20.62 10.29 22 275616 12311 50317175
Corneal disorder 20.60 10.29 34 275604 1592 50327894
Haematoma 20.39 10.29 91 275547 30419 50299067
Hyperkalaemia 20.24 10.29 166 275472 47923 50281563
Mantle cell lymphoma recurrent 20.20 10.29 11 275627 115 50329371
Gastroenteritis norovirus 20.10 10.29 35 275603 1712 50327774
Pneumonia viral 19.99 10.29 82 275556 6752 50322734
Stem cell transplant 19.96 10.29 34 275604 1634 50327852
Mucocutaneous ulceration 19.93 10.29 12 275626 154 50329332
Bipolar disorder 19.92 10.29 6 275632 6751 50322735
Therapeutic response decreased 19.89 10.29 163 275475 47068 50282418
Aplastic anaemia 19.89 10.29 89 275549 7614 50321872
Atrial septal defect 19.88 10.29 5 275633 6336 50323150
Scar 19.85 10.29 21 275617 11797 50317689
Birdshot chorioretinopathy 19.83 10.29 9 275629 61 50329425
Coronary artery occlusion 19.82 10.29 8 275630 7495 50321991
Venous thrombosis limb 19.79 10.29 44 275594 2578 50326908
Hair texture abnormal 19.79 10.29 54 275584 3602 50325884
Oral disorder 19.78 10.29 90 275548 7754 50321732
Musculoskeletal chest pain 19.74 10.29 170 275468 18316 50311170
Device leakage 19.70 10.29 4 275634 5874 50323612
Alveolitis 19.67 10.29 43 275595 2491 50326995
Adenocarcinoma pancreas 19.64 10.29 26 275612 996 50328490
Spinal osteoarthritis 19.53 10.29 29 275609 14063 50315423
Hypogeusia 19.53 10.29 27 275611 1079 50328407
Complication associated with device 19.51 10.29 31 275607 14624 50314862
Adenocarcinoma of colon 19.48 10.29 39 275599 2123 50327363
Compression fracture 19.47 10.29 73 275565 5764 50323722
Amenorrhoea 19.43 10.29 11 275627 8473 50321013
Nail dystrophy 19.37 10.29 23 275615 788 50328698
Intervertebral disc degeneration 19.35 10.29 27 275611 13434 50316052
Cerebral aspergillosis 19.28 10.29 16 275622 351 50329135
Lactose intolerance 19.26 10.29 43 275595 2527 50326959
Electrocardiogram QT prolonged 19.24 10.29 185 275453 51701 50277785
Product administration error 19.12 10.29 50 275588 19649 50309837
Alpha haemolytic streptococcal infection 19.09 10.29 24 275614 873 50328613
Disability 19.00 10.29 25 275613 12750 50316736
Abnormal dreams 18.96 10.29 14 275624 9363 50320123
Therapy interrupted 18.92 10.29 52 275586 20100 50309386
Lip swelling 18.91 10.29 70 275568 24666 50304820
Philadelphia chromosome positive 18.83 10.29 16 275622 363 50329123
Cholecystitis chronic 18.83 10.29 15 275623 9654 50319832
Refractory anaemia with ringed sideroblasts 18.76 10.29 5 275633 3 50329483
Babesiosis 18.72 10.29 13 275625 216 50329270
Blood immunoglobulin A increased 18.68 10.29 16 275622 367 50329119
Spinal stenosis 18.67 10.29 28 275610 13522 50315964
Post procedural infection 18.56 10.29 9 275629 7567 50321919
Incorrect product administration duration 18.56 10.29 14 275624 9261 50320225
Movement disorder 18.49 10.29 43 275595 17589 50311897
Adverse event 18.45 10.29 151 275487 43612 50285874
Enlarged uvula 18.44 10.29 12 275626 178 50329308
Malaise 18.44 10.29 1575 274063 333957 49995529
Respiratory depression 18.38 10.29 23 275615 11987 50317499
Maternal exposure before pregnancy 18.36 10.29 4 275634 5593 50323893
Leukaemia recurrent 18.33 10.29 28 275610 1226 50328260
Femur fracture 18.30 10.29 124 275514 37340 50292146
Enterococcal bacteraemia 18.27 10.29 28 275610 1230 50328256
Lymphoedema 18.26 10.29 98 275540 9024 50320462
Ileus paralytic 18.23 10.29 56 275582 3994 50325492
Hypothalamic pituitary adrenal axis suppression 18.22 10.29 11 275627 142 50329344
Polyp 18.20 10.29 4 275634 5558 50323928
Enterobacter infection 18.15 10.29 35 275603 1853 50327633
Subclavian vein thrombosis 18.10 10.29 34 275604 1765 50327721
Food allergy 17.99 10.29 11 275627 8126 50321360
Blood cholesterol increased 17.97 10.29 203 275435 55012 50274474
Staphylococcal bacteraemia 17.97 10.29 63 275575 4814 50324672
Staphylococcal sepsis 17.95 10.29 81 275557 6955 50322531
Chalazion 17.92 10.29 15 275623 333 50329153
Pseudomyopia 17.91 10.29 8 275630 52 50329434
Iris atrophy 17.91 10.29 8 275630 52 50329434
Tonsillar disorder 17.89 10.29 25 275613 1009 50328477
Necrotising fasciitis 17.78 10.29 42 275596 2562 50326924
Refractory anaemia with an excess of blasts 17.77 10.29 16 275622 393 50329093
Human herpesvirus 6 infection 17.76 10.29 42 275596 2564 50326922
Haematemesis 17.75 10.29 84 275554 27641 50301845
Spinal compression fracture 17.74 10.29 124 275514 12532 50316954
Premature delivery 17.66 10.29 202 275436 23461 50306025
Cytomegalovirus colitis 17.65 10.29 35 275603 1892 50327594
Stomatitis 17.60 10.29 697 274941 100647 50228839
Chronic myelomonocytic leukaemia 17.58 10.29 14 275624 289 50329197
Palmar erythema 17.58 10.29 31 275607 1532 50327954
Oral pain 17.49 10.29 211 275427 24822 50304664
Mood swings 17.47 10.29 38 275600 15916 50313570
Catabolic state 17.42 10.29 8 275630 56 50329430
Transplant rejection 17.38 10.29 16 275622 9593 50319893
Hypothermia 17.38 10.29 24 275614 11992 50317494
Meningitis cryptococcal 17.36 10.29 26 275612 1119 50328367
Neck pain 17.35 10.29 213 275425 56854 50272632
Virilism 17.34 10.29 7 275631 34 50329452
Vitamin D deficiency 17.28 10.29 22 275616 11380 50318106
Drug level decreased 17.20 10.29 7 275631 6526 50322960
Meningoencephalitis herpetic 17.20 10.29 25 275613 1047 50328439
Deformity 17.19 10.29 11 275627 7929 50321557
Myelopathy 17.15 10.29 41 275597 2520 50326966
Colitis microscopic 17.15 10.29 7 275631 6513 50322973
Vein discolouration 17.15 10.29 12 275626 202 50329284
Pruritus 17.11 10.29 1321 274317 282247 50047239
Diverticulitis intestinal perforated 17.09 10.29 6 275632 18 50329468
Anhedonia 17.06 10.29 16 275622 9508 50319978
Nightmare 17.06 10.29 39 275599 16047 50313439
Breast cancer female 17.05 10.29 8 275630 6854 50322632
Angina pectoris 16.97 10.29 79 275559 26109 50303377
Serotonin syndrome 16.95 10.29 73 275565 24640 50304846
Vitreous loss 16.87 10.29 4 275634 0 50329486
Tuberculosis 16.84 10.29 18 275620 10065 50319421
Intermenstrual bleeding 16.84 10.29 8 275630 6806 50322680
Eosinophil count increased 16.82 10.29 14 275624 8816 50320670
Device use error 16.80 10.29 4 275634 5262 50324224
Hyperproteinaemia 16.79 10.29 9 275629 91 50329395
Metastases to meninges 16.72 10.29 35 275603 1967 50327519
Thrombotic microangiopathy 16.62 10.29 93 275545 8698 50320788
Enterococcal sepsis 16.61 10.29 27 275611 1248 50328238
Fungaemia 16.60 10.29 35 275603 1977 50327509
Urinary tract infection 16.53 10.29 1426 274212 222594 50106892
Listeriosis 16.52 10.29 28 275610 1340 50328146
Chemotherapy 16.50 10.29 28 275610 1341 50328145
Herpes simplex 16.47 10.29 80 275558 7082 50322404
Tooth erosion 16.44 10.29 16 275622 435 50329051
Tuberculoma of central nervous system 16.43 10.29 14 275624 319 50329167
Diverticular perforation 16.36 10.29 46 275592 3122 50326364
Miosis 16.23 10.29 7 275631 6303 50323183
Meniscus injury 16.20 10.29 7 275631 6295 50323191
Swelling face 16.20 10.29 388 275250 52207 50277279
Acute respiratory distress syndrome 16.15 10.29 181 275457 20918 50308568
Arachnoiditis 16.14 10.29 13 275625 273 50329213
Device failure 16.13 10.29 5 275633 5523 50323963
Pulmonary hypertension 16.13 10.29 111 275527 33306 50296180
Madarosis 16.10 10.29 40 275598 2520 50326966
Transplant dysfunction 16.09 10.29 3 275635 4681 50324805
Endocarditis bacterial 16.08 10.29 18 275620 578 50328908
Escherichia sepsis 16.06 10.29 56 275582 4268 50325218
Gastrointestinal toxicity 16.03 10.29 59 275579 4618 50324868
Soft tissue disorder 16.02 10.29 55 275583 4159 50325327
Fungal abscess central nervous system 15.99 10.29 5 275633 9 50329477
Chronic kidney disease 15.96 10.29 139 275499 39632 50289854
Bone marrow infiltration 15.94 10.29 16 275622 452 50329034
Metapneumovirus infection 15.93 10.29 21 275617 801 50328685
Pulmonary sepsis 15.93 10.29 27 275611 1292 50328194
Bone debridement 15.91 10.29 12 275626 228 50329258
Cancer pain 15.83 10.29 40 275598 2547 50326939
Genital haemorrhage 15.82 10.29 8 275630 6566 50322920
Nail infection 15.81 10.29 34 275604 1947 50327539
Infection reactivation 15.81 10.29 23 275615 964 50328522
Varicella zoster virus infection 15.77 10.29 39 275599 2450 50327036
Rotator cuff syndrome 15.77 10.29 24 275614 11520 50317966
Akathisia 15.73 10.29 13 275625 8216 50321270
Pulse waveform abnormal 15.72 10.29 8 275630 72 50329414
Target skin lesion 15.69 10.29 9 275629 105 50329381
Hypomagnesaemia 15.67 10.29 194 275444 22962 50306524
Ankle brachial index decreased 15.62 10.29 8 275630 73 50329413
Menstruation irregular 15.59 10.29 7 275631 6155 50323331
Botryomycosis 15.59 10.29 6 275632 25 50329461
Computerised tomogram thorax 15.56 10.29 10 275628 145 50329341
Rectal adenocarcinoma 15.56 10.29 17 275621 531 50328955
Myopathy 15.54 10.29 94 275544 9045 50320441
Atelectasis 15.50 10.29 160 275478 18110 50311376
Necrotising retinitis 15.48 10.29 13 275625 290 50329196
JC virus infection 15.48 10.29 32 275606 1783 50327703
Pneumonia aspiration 15.46 10.29 102 275536 30902 50298584
Infusion site swelling 15.46 10.29 10 275628 7166 50322320
B precursor type acute leukaemia 15.45 10.29 10 275628 147 50329339
Embolism venous 15.40 10.29 39 275599 2486 50327000
Application site erythema 15.39 10.29 3 275635 4535 50324951
Aggression 15.34 10.29 61 275577 21055 50308431
Failure to thrive 15.33 10.29 72 275566 6286 50323200
Meningitis listeria 15.32 10.29 16 275622 474 50329012
Acute respiratory failure 15.32 10.29 231 275407 28551 50300935
Carotid intima-media thickness increased 15.26 10.29 8 275630 77 50329409
Hypophosphataemia 15.25 10.29 88 275550 8326 50321160
Lymphorrhoea 15.24 10.29 7 275631 49 50329437
Streptococcal bacteraemia 15.23 10.29 28 275610 1430 50328056
Pain in jaw 15.12 10.29 135 275503 38293 50291193
Sense of oppression 15.10 10.29 22 275616 923 50328563
Choroiditis 15.05 10.29 9 275629 114 50329372
Iridocyclitis 15.04 10.29 34 275604 2015 50327471
Pre-eclampsia 15.02 10.29 13 275625 8031 50321455
Skin exfoliation 15.00 10.29 262 275376 33350 50296136
Obstructive airways disorder 14.99 10.29 40 275598 15612 50313874
Emotional distress 14.95 10.29 93 275545 28570 50300916
Respiratory depth decreased 14.89 10.29 6 275632 29 50329457
Cerebral venous thrombosis 14.81 10.29 32 275606 1839 50327647
Blood fibrinogen decreased 14.79 10.29 18 275620 633 50328853
Vitritis 14.78 10.29 21 275617 861 50328625
Product adhesion issue 14.70 10.29 3 275635 4389 50325097
Haemophilus bacteraemia 14.65 10.29 4 275634 3 50329483
Acne 14.62 10.29 56 275582 19539 50309947
Oesophageal squamous cell carcinoma 14.59 10.29 9 275629 121 50329365
Polyarthritis 14.57 10.29 13 275625 7914 50321572
Blood creatine phosphokinase increased 14.57 10.29 84 275554 26283 50303203
Herpes zoster reactivation 14.56 10.29 6 275632 31 50329455
Joint injury 14.55 10.29 65 275573 21724 50307762
Plasma cell myeloma refractory 14.49 10.29 5 275633 14 50329472
Genital rash 14.49 10.29 15 275623 440 50329046
Hemiparesis 14.45 10.29 170 275468 19878 50309608
Scoliosis 14.39 10.29 9 275629 6567 50322919
Macular degeneration 14.37 10.29 36 275602 14352 50315134
Urosepsis 14.36 10.29 138 275500 15327 50314159
Renal disorder 14.35 10.29 220 275418 27285 50302201
Superior vena cava occlusion 14.35 10.29 7 275631 57 50329429
Emphysematous cystitis 14.34 10.29 9 275629 125 50329361
Crohn's disease 14.33 10.29 4 275634 4729 50324757
Respiratory arrest 14.33 10.29 100 275538 29909 50299577
Pulmonary mucormycosis 14.32 10.29 11 275627 215 50329271
Non-small cell lung cancer metastatic 14.29 10.29 16 275622 514 50328972
Alanine aminotransferase increased 14.27 10.29 603 275035 87756 50241730
Hypergeusia 14.24 10.29 5 275633 15 50329471
Hallucination 14.23 10.29 174 275464 46483 50283003
Blood calcium abnormal 14.15 10.29 23 275615 1063 50328423
Cataract traumatic 14.12 10.29 4 275634 4 50329482
Lipogranuloma 14.12 10.29 4 275634 4 50329482
Palatal ulcer 14.04 10.29 7 275631 60 50329426
Polychromasia 14.04 10.29 8 275630 92 50329394
Adjusted calcium increased 14.00 10.29 5 275633 16 50329470
Intentional dose omission 13.98 10.29 5 275633 5045 50324441
Bone infarction 13.94 10.29 11 275627 224 50329262
Enteritis 13.90 10.29 75 275563 6920 50322566
Lentigo maligna 13.81 10.29 10 275628 178 50329308
Mucosal infection 13.80 10.29 9 275629 134 50329352
Expired product administered 13.80 10.29 6 275632 5376 50324110
Corneal perforation 13.77 10.29 15 275623 467 50329019
Frequent bowel movements 13.76 10.29 35 275603 13883 50315603
Steroid diabetes 13.76 10.29 21 275617 919 50328567
Hyperamylasaemia 13.68 10.29 13 275625 343 50329143
Electrocardiogram QRS complex prolonged 13.63 10.29 6 275632 5338 50324148
Pneumonia bacterial 13.61 10.29 77 275561 7232 50322254
Postictal state 13.59 10.29 21 275617 929 50328557
Hyperpyrexia 13.58 10.29 42 275596 3007 50326479
Therapeutic response delayed 13.55 10.29 16 275622 545 50328941
Monoclonal immunoglobulin increased 13.54 10.29 8 275630 99 50329387
Frustration tolerance decreased 13.51 10.29 7 275631 5667 50323819
Blood gases abnormal 13.44 10.29 17 275621 622 50328864
Thiopurine methyltransferase decreased 13.42 10.29 12 275626 292 50329194
Hypophagia 13.42 10.29 219 275419 27509 50301977
Nasal disorder 13.41 10.29 35 275603 2273 50327213
Osteomyelitis bacterial 13.39 10.29 10 275628 187 50329299
Low density lipoprotein increased 13.39 10.29 7 275631 5639 50323847
Circulatory collapse 13.29 10.29 167 275471 19833 50309653
Uterine leiomyoma 13.28 10.29 14 275624 7877 50321609
Salmonella bacteraemia 13.25 10.29 9 275629 144 50329342
Plasma cell myeloma in remission 13.24 10.29 4 275634 6 50329480
Renal amyloidosis 13.20 10.29 9 275629 145 50329341
Lymphocyte count decreased 13.19 10.29 209 275429 26098 50303388
Abortion induced 13.18 10.29 19 275619 9325 50320161
Acute kidney injury 13.17 10.29 1427 274211 226631 50102855
Granuloma 13.13 10.29 5 275633 4853 50324633
Foetal growth restriction 13.13 10.29 71 275567 6556 50322930
Eye infection 13.09 10.29 92 275546 9314 50320172
Infusion related reaction 13.04 10.29 773 274865 168784 50160702
Low birth weight baby 13.03 10.29 65 275573 5816 50323670
Ankle fracture 13.02 10.29 43 275595 15679 50313807
Major depression 13.01 10.29 11 275627 6873 50322613
Oedema peripheral 13.01 10.29 1014 274624 156947 50172539
Intraocular pressure decreased 13.00 10.29 8 275630 107 50329379
Sputum discoloured 13.00 10.29 34 275604 13361 50316125
Infusion site streaking 13.00 10.29 14 275624 430 50329056
Therapy non-responder 12.98 10.29 367 275271 50655 50278831
Sinus polyp 12.96 10.29 12 275626 306 50329180
Cerebellar haemangioma 12.96 10.29 7 275631 72 50329414
Chemical burns of eye 12.96 10.29 7 275631 72 50329414
Renal-limited thrombotic microangiopathy 12.86 10.29 4 275634 7 50329479
Substance-induced mood disorder 12.86 10.29 4 275634 7 50329479
Loss of consciousness 12.85 10.29 452 275186 103901 50225585
Metastatic malignant melanoma 12.84 10.29 23 275615 1151 50328335
Alopecia totalis 12.83 10.29 12 275626 310 50329176
Iris adhesions 12.83 10.29 12 275626 310 50329176
Caesarean section 12.79 10.29 43 275595 15596 50313890
Gene mutation 12.76 10.29 24 275614 1247 50328239
Adenoviral haemorrhagic cystitis 12.73 10.29 9 275629 154 50329332
Post procedural complication 12.72 10.29 41 275597 15063 50314423
Foetal exposure during delivery 12.71 10.29 6 275632 45 50329441
Bradyphrenia 12.68 10.29 9 275629 6143 50323343
Soft tissue infection 12.68 10.29 30 275608 1832 50327654
Non-small cell lung cancer 12.66 10.29 40 275598 2897 50326589
Cleft palate repair 12.66 10.29 3 275635 0 50329486
Oropharyngeal squamous cell carcinoma 12.66 10.29 3 275635 0 50329486
Radiotherapy to brain 12.66 10.29 3 275635 0 50329486
Secondary immunodeficiency 12.64 10.29 23 275615 1165 50328321
Hyphaema 12.64 10.29 9 275629 156 50329330
Gastric perforation 12.63 10.29 26 275612 1444 50328042
Rash 12.61 10.29 2631 273007 434840 49894646
Encephalitis 12.61 10.29 76 275562 7304 50322182
Injection site irritation 12.58 10.29 4 275634 4346 50325140
Hair colour changes 12.58 10.29 38 275600 2686 50326800
Throat tightness 12.57 10.29 171 275467 20676 50308810
Drug tolerance decreased 12.55 10.29 19 275619 9141 50320345
Skin sensitisation 12.54 10.29 18 275620 745 50328741
Enterocolitis infectious 12.53 10.29 26 275612 1452 50328034
Unintentional medical device removal 12.51 10.29 7 275631 5428 50324058
General physical health deterioration 12.51 10.29 919 274719 141515 50187971
Asphyxia 12.48 10.29 7 275631 5420 50324066
Corneal infiltrates 12.45 10.29 8 275630 116 50329370
Vascular compression 12.45 10.29 8 275630 116 50329370
Joint destruction 12.45 10.29 3 275635 3913 50325573
Haematochezia 12.45 10.29 148 275490 39734 50289752
Nodule 12.42 10.29 49 275589 16954 50312532
Haemolytic anaemia 12.42 10.29 90 275548 9202 50320284
Immune system disorder 12.41 10.29 82 275556 8135 50321351
Myeloma cast nephropathy 12.39 10.29 8 275630 117 50329369
Peritonitis viral 12.39 10.29 6 275632 48 50329438
Capillary leak syndrome 12.38 10.29 30 275608 1860 50327626
Angina unstable 12.33 10.29 11 275627 6695 50322791
Sialoadenitis 12.31 10.29 25 275613 1375 50328111
Impaired quality of life 12.30 10.29 9 275629 6047 50323439
Atypical pneumonia 12.29 10.29 46 275592 3629 50325857
Peritonitis bacterial 12.26 10.29 5 275633 4656 50324830
Urethral cancer 12.21 10.29 4 275634 9 50329477
Ear pain 12.19 10.29 97 275541 28186 50301300
Mental disorder 12.18 10.29 70 275568 21921 50307565
Demyelination 12.18 10.29 9 275629 6017 50323469
Intraductal proliferative breast lesion 12.18 10.29 36 275602 2514 50326972
Injection site discolouration 12.16 10.29 12 275626 6962 50322524
Diastolic hypotension 12.10 10.29 7 275631 83 50329403
Leukaemic lymphoma 12.10 10.29 7 275631 83 50329403
Superior sagittal sinus thrombosis 12.10 10.29 17 275621 690 50328796
Cardiomyopathy 12.06 10.29 134 275504 15452 50314034
Skin candida 12.04 10.29 24 275614 1302 50328184
Apathy 12.03 10.29 14 275624 7534 50321952
Oxygen saturation 12.02 10.29 9 275629 169 50329317
Atypical haemolytic uraemic syndrome 12.01 10.29 15 275623 542 50328944
Drug dependence 11.99 10.29 61 275577 19698 50309788
Human herpesvirus 8 infection 11.99 10.29 10 275628 221 50329265
Muscle rigidity 11.97 10.29 22 275616 9807 50319679
White blood cell count increased 11.97 10.29 160 275478 42080 50287406
Phyllodes tumour 11.96 10.29 5 275633 27 50329459
B-cell type acute leukaemia 11.94 10.29 8 275630 125 50329361
Eye abscess 11.94 10.29 8 275630 125 50329361
Actinomycosis 11.92 10.29 20 275618 949 50328537
Drug clearance decreased 11.92 10.29 22 275616 1127 50328359
Cerebral artery thrombosis 11.90 10.29 12 275626 341 50329145
Tracheal deviation 11.88 10.29 6 275632 53 50329433
Dysaesthesia 11.88 10.29 46 275592 3689 50325797
Visceral leishmaniasis 11.87 10.29 14 275624 476 50329010
Heart rate increased 11.85 10.29 325 275313 76925 50252561
Escherichia urinary tract infection 11.84 10.29 97 275541 10298 50319188
Skin ulcer 11.83 10.29 129 275509 35189 50294297
Papule 11.82 10.29 51 275587 4294 50325192
Malignant transformation 11.81 10.29 12 275626 344 50329142
Bone marrow disorder 11.79 10.29 30 275608 1918 50327568
Therapy cessation 11.78 10.29 88 275550 25923 50303563
Increased appetite 11.77 10.29 82 275556 8279 50321207
Reflux gastritis 11.75 10.29 19 275619 874 50328612
Thrombophlebitis 11.75 10.29 48 275590 3945 50325541
Intracranial tumour haemorrhage 11.72 10.29 8 275630 129 50329357
Laryngeal inflammation 11.72 10.29 8 275630 129 50329357
Application site pruritus 11.71 10.29 3 275635 3756 50325730
Pseudomonal bacteraemia 11.69 10.29 23 275615 1236 50328250
Paraparesis 11.69 10.29 31 275607 2033 50327453
Blood pressure diastolic increased 11.66 10.29 14 275624 7429 50322057
Uterine fistula 11.65 10.29 4 275634 11 50329475
Light chain analysis 11.65 10.29 4 275634 11 50329475
Disturbance in attention 11.64 10.29 111 275527 31075 50298411
Amnesia 11.64 10.29 161 275477 42099 50287387
Immune-mediated encephalitis 11.62 10.29 7 275631 90 50329396
Retinal detachment 11.59 10.29 57 275581 5072 50324414
Body temperature decreased 11.51 10.29 48 275590 16347 50313139
Chills 11.43 10.29 640 274998 96047 50233439
Morganella infection 11.42 10.29 15 275623 570 50328916
Pharyngitis streptococcal 11.38 10.29 19 275619 8789 50320697
Subileus 11.37 10.29 37 275601 2722 50326764
Arterial occlusive disease 11.35 10.29 6 275632 4802 50324684
Dyskinesia 11.35 10.29 97 275541 27764 50301722
Arteriosclerosis 11.34 10.29 20 275618 9057 50320429
Tachycardia 11.34 10.29 658 274980 99105 50230381
Dermatitis acneiform 11.33 10.29 48 275590 4009 50325477
Rash maculo-papular 11.30 10.29 206 275432 26435 50303051
Pulse absent 11.28 10.29 54 275584 4752 50324734
Urinary tract infection enterococcal 11.28 10.29 34 275604 2400 50327086
Gastritis 11.24 10.29 120 275518 32863 50296623
Guillain-Barre syndrome 11.20 10.29 43 275595 3434 50326052
Dysaesthesia pharynx 11.17 10.29 8 275630 140 50329346
Cholangitis infective 11.13 10.29 9 275629 190 50329296
Transverse sinus thrombosis 11.12 10.29 14 275624 510 50328976
Maternal exposure timing unspecified 11.07 10.29 3 275635 3617 50325869
Colony stimulating factor therapy 11.07 10.29 11 275627 307 50329179
Bronchitis viral 11.04 10.29 19 275619 921 50328565
Renal replacement therapy 11.00 10.29 6 275632 63 50329423
Appendiceal abscess 10.98 10.29 9 275629 194 50329292
Cardiac failure 10.97 10.29 513 275125 75527 50253959
Brain tumour operation 10.93 10.29 4 275634 14 50329472
Blood potassium increased 10.90 10.29 49 275589 16349 50313137
Meningitis streptococcal 10.88 10.29 8 275630 146 50329340
Device related infection 10.88 10.29 166 275472 20569 50308917
Anaphylactoid reaction 10.87 10.29 42 275596 3364 50326122
Retinal ischaemia 10.87 10.29 11 275627 314 50329172
Histiocytic sarcoma 10.84 10.29 6 275632 65 50329421
Catheter site bruise 10.84 10.29 11 275627 315 50329171
Listeria encephalitis 10.83 10.29 10 275628 254 50329232
Gastrointestinal motility disorder 10.83 10.29 51 275587 4458 50325028
Epstein Barr virus positive mucocutaneous ulcer 10.78 10.29 12 275626 383 50329103
Torsade de pointes 10.77 10.29 31 275607 11804 50317682
Rash pruritic 10.77 10.29 339 275299 47507 50281979
Hyperglycaemic hyperosmolar nonketotic syndrome 10.74 10.29 15 275623 605 50328881
Blood stem cell transplant failure 10.70 10.29 8 275630 150 50329336
Serology abnormal 10.59 10.29 3 275635 3 50329483
Kernicterus 10.59 10.29 3 275635 3 50329483
Splenic infection fungal 10.59 10.29 3 275635 3 50329483
Feeling jittery 10.57 10.29 100 275538 11060 50318426
Bundle branch block left 10.54 10.29 11 275627 6219 50323267
Head injury 10.53 10.29 82 275556 23938 50305548
Dysphonia 10.52 10.29 282 275356 38610 50290876
Emphysema 10.51 10.29 21 275617 9072 50320414
Acute febrile neutrophilic dermatosis 10.50 10.29 35 275603 2607 50326879
Bronchitis chronic 10.46 10.29 4 275634 3873 50325613
Second primary malignancy 10.44 10.29 69 275569 6845 50322641
Somnambulism 10.42 10.29 7 275631 4917 50324569
Blood lactate dehydrogenase increased 10.41 10.29 157 275481 19405 50310081
Aplasia pure red cell 10.34 10.29 5 275633 4210 50325276
Stenotrophomonas test positive 10.33 10.29 4 275634 17 50329469
Neuralgia 10.33 10.29 172 275466 21691 50307795
Cyst 10.32 10.29 33 275605 12154 50317332
Endocarditis 10.31 10.29 55 275583 5052 50324434
Arteriosclerosis coronary artery 10.31 10.29 16 275622 7620 50321866

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 2319.41 11.28 2211 262407 34904 29275005
Neuropathy peripheral 1308.16 11.28 2307 262311 68720 29241189
Neutropenia 935.76 11.28 2944 261674 128767 29181142
Pneumonia 830.58 11.28 5290 259328 314882 28995027
Thrombocytopenia 772.26 11.28 2804 261814 132019 29177890
Febrile neutropenia 706.78 11.28 2409 262209 109831 29200078
Completed suicide 676.56 11.28 31 264587 90215 29219694
Drug abuse 575.05 11.28 35 264583 79848 29230061
Plasma cell myeloma recurrent 503.06 11.28 347 264271 3336 29306573
Drug interaction 475.82 11.28 643 263975 196742 29113167
Unevaluable event 473.40 11.28 910 263708 28941 29280968
Deep vein thrombosis 424.88 11.28 1303 263315 56096 29253813
Platelet count decreased 414.91 11.28 1945 262673 102727 29207182
Pancytopenia 358.91 11.28 1585 263033 81583 29228326
Full blood count decreased 335.30 11.28 551 264067 15441 29294468
Thrombosis 331.43 11.28 991 263627 42054 29267855
Overdose 330.71 11.28 150 264468 79669 29230240
Fatigue 324.19 11.28 4285 260333 312536 28997373
Intentional overdose 323.12 11.28 4 264614 38524 29271385
Plasmacytoma 306.52 11.28 244 264374 2971 29306938
White blood cell count decreased 301.28 11.28 1509 263109 81853 29228056
Pulmonary embolism 286.92 11.28 1400 263218 75134 29234775
Constipation 284.25 11.28 1871 262747 112289 29197620
Disease progression 280.76 11.28 1461 263157 80455 29229454
Off label use 247.56 11.28 3918 260700 296882 29013027
Cytopenia 233.23 11.28 359 264259 9500 29300409
Sepsis 232.71 11.28 2119 262499 140563 29169346
Laboratory test abnormal 224.24 11.28 500 264118 17685 29292224
Rheumatoid arthritis 222.73 11.28 17 264601 32135 29277774
Rhabdomyolysis 218.45 11.28 137 264481 60671 29249238
Neutropenic sepsis 206.41 11.28 374 264244 11353 29298556
Suicide attempt 203.45 11.28 31 264587 34079 29275830
Suicidal ideation 201.55 11.28 34 264584 34682 29275227
Tumour lysis syndrome 192.11 11.28 400 264218 13484 29296425
Neutrophil count decreased 190.50 11.28 834 263784 42733 29267176
Arthralgia 189.37 11.28 629 263989 138988 29170921
Septic shock 188.75 11.28 1078 263540 61482 29248427
Blood creatine phosphokinase increased 178.48 11.28 70 264548 40574 29269335
Polyneuropathy 171.54 11.28 353 264265 11799 29298110
Plasma cell leukaemia 171.22 11.28 100 264518 697 29309212
Hiccups 170.87 11.28 294 264324 8559 29301350
Endophthalmitis 166.87 11.28 164 264454 2684 29307225
Injection site pain 165.31 11.28 43 264575 32403 29277506
Death 157.51 11.28 4087 260531 337997 28971912
Intentional product misuse 156.70 11.28 57 264561 34604 29275305
Adverse drug reaction 154.55 11.28 520 264098 23500 29286409
Psoriasis 154.40 11.28 48 264570 32179 29277730
Pyrexia 153.56 11.28 3507 261111 284115 29025794
Myelodysplastic syndrome 150.65 11.28 424 264194 17370 29292539
Inappropriate schedule of product administration 150.54 11.28 107 264511 44365 29265544
Pneumocystis jirovecii pneumonia 146.18 11.28 404 264214 16375 29293534
Depression 144.67 11.28 344 264274 84803 29225106
Drug ineffective 142.40 11.28 2341 262277 360829 28949080
Hospitalisation 141.32 11.28 122 264496 45866 29264043
Diarrhoea 133.85 11.28 3907 260711 328791 28981118
Complication of device insertion 133.81 11.28 44 264574 44 29309865
Wrong technique in product usage process 133.32 11.28 57 264561 31371 29278538
Squamous cell carcinoma of skin 132.05 11.28 274 264344 9212 29300697
Intraocular pressure increased 128.48 11.28 185 264433 4604 29305305
Coronary artery disease 126.58 11.28 125 264493 44065 29265844
Mucosal inflammation 125.50 11.28 588 264030 31007 29278902
Leukopenia 124.18 11.28 883 263735 54320 29255589
Strongyloidiasis 124.18 11.28 127 264491 2185 29307724
Drug dependence 123.00 11.28 20 264598 20961 29288948
Febrile bone marrow aplasia 122.50 11.28 229 264389 7122 29302787
Osteonecrosis 122.24 11.28 330 264288 13189 29296720
Venoocclusive liver disease 119.69 11.28 219 264399 6698 29303211
Light chain analysis increased 116.76 11.28 89 264529 1012 29308897
Hypoglycaemia 116.60 11.28 157 264461 48189 29261720
Osteonecrosis of jaw 114.79 11.28 367 264251 16143 29293766
Drug hypersensitivity 114.08 11.28 279 264339 68127 29241782
Condition aggravated 114.08 11.28 803 263815 145492 29164417
Headache 113.92 11.28 1002 263616 173005 29136904
Anxiety 113.28 11.28 388 264230 84977 29224932
Aggression 110.76 11.28 93 264525 35448 29274461
Haematotoxicity 105.84 11.28 204 264414 6495 29303414
Serotonin syndrome 104.22 11.28 16 264602 17496 29292413
Myocardial infarction 103.78 11.28 571 264047 109725 29200184
Rash 101.76 11.28 2317 262301 187502 29122407
Cytomegalovirus chorioretinitis 101.75 11.28 135 264483 3103 29306806
Myalgia 101.23 11.28 332 264286 73687 29236222
Neuroleptic malignant syndrome 100.21 11.28 13 264605 16135 29293774
COVID-19 pneumonia 100.09 11.28 246 264372 9276 29300633
Therapy partial responder 98.16 11.28 171 264447 5028 29304881
Anaemia 98.00 11.28 2421 262197 198530 29111379
Drug withdrawal syndrome 95.17 11.28 22 264596 17962 29291947
Tooth disorder 94.73 11.28 241 264377 9288 29300621
Infection 94.66 11.28 1077 263541 75674 29234235
Stress 92.71 11.28 38 264580 21452 29288457
Incorrect dose administered 92.52 11.28 95 264523 32889 29277020
Hallucination 91.72 11.28 162 264456 44550 29265359
Angioedema 91.71 11.28 90 264528 31825 29278084
Peripheral sensory neuropathy 91.56 11.28 179 264439 5760 29304149
Malignant neoplasm progression 90.45 11.28 1035 263583 72824 29237085
Hypofibrinogenaemia 88.99 11.28 87 264531 1414 29308495
Bone marrow failure 88.69 11.28 482 264136 26967 29282942
Sedation 86.88 11.28 24 264594 17381 29292528
Electrocardiogram QT prolonged 85.47 11.28 119 264499 36018 29273891
Mucormycosis 85.10 11.28 160 264458 4998 29304911
Product prescribing error 83.92 11.28 28 264590 17948 29291961
Body height decreased 83.52 11.28 127 264491 3323 29306586
COVID-19 83.25 11.28 580 264038 35434 29274475
Monoclonal immunoglobulin present 83.21 11.28 67 264551 830 29309079
International normalised ratio increased 82.93 11.28 170 264448 44202 29265707
Contraindicated product administered 82.61 11.28 30 264588 18236 29291673
Asthma 81.53 11.28 110 264508 33739 29276170
Multiple sclerosis relapse 79.18 11.28 6 264612 11413 29298496
Bone lesion 77.78 11.28 108 264510 2596 29307313
Myelosuppression 77.13 11.28 263 264355 11964 29297945
Corneal oedema 76.86 11.28 71 264547 1071 29308838
Hyperkalaemia 76.12 11.28 287 264331 61105 29248804
Posterior reversible encephalopathy syndrome 76.08 11.28 214 264404 8762 29301147
Blood pressure increased 75.60 11.28 371 264247 73432 29236477
Respiratory arrest 75.21 11.28 72 264546 25761 29284148
Loss of personal independence in daily activities 75.13 11.28 70 264548 25370 29284539
Intentional self-injury 75.04 11.28 11 264607 12450 29297459
Musculoskeletal stiffness 74.78 11.28 138 264480 37320 29272589
Lactic acidosis 74.16 11.28 97 264521 30150 29279759
Bacteraemia 73.99 11.28 316 264302 16007 29293902
Blood pressure fluctuation 73.95 11.28 43 264575 19851 29290058
Ageusia 73.71 11.28 211 264407 8727 29301182
Hypercalcaemia 73.21 11.28 266 264352 12493 29297416
Coma 72.99 11.28 152 264466 39298 29270611
Psoriatic arthropathy 71.96 11.28 21 264597 14670 29295239
Cataract 71.65 11.28 392 264226 21986 29287923
Stomatitis 70.69 11.28 571 264047 36542 29273367
Abnormal behaviour 70.24 11.28 62 264556 23065 29286844
Hyperglycaemia 69.97 11.28 536 264082 33751 29276158
Product substitution issue 69.15 11.28 3 264615 9169 29300740
Cytokine release syndrome 69.03 11.28 266 264352 12853 29297056
Somnolence 68.69 11.28 525 264093 93430 29216479
Acute myeloid leukaemia 67.53 11.28 310 264308 16203 29293706
Surgery 67.34 11.28 12 264606 11767 29298142
Poisoning 67.22 11.28 6 264612 9987 29299922
Product quality issue 65.56 11.28 30 264588 15865 29294044
Synovitis 64.69 11.28 10 264608 10880 29299029
Injury 64.20 11.28 46 264572 19000 29290909
Respiratory tract infection 64.13 11.28 294 264324 15357 29294552
Bone pain 63.69 11.28 330 264288 18122 29291787
Lymphopenia 63.68 11.28 265 264353 13268 29296641
Treatment noncompliance 63.28 11.28 74 264544 24153 29285756
Respiratory depression 63.24 11.28 21 264597 13502 29296407
Dyskinesia 63.10 11.28 52 264566 20009 29289900
Parainfluenzae virus infection 61.97 11.28 88 264530 2161 29307748
Diffuse large B-cell lymphoma refractory 61.43 11.28 57 264561 865 29309044
Sleep apnoea syndrome 61.32 11.28 41 264577 17558 29292351
Accidental overdose 61.28 11.28 41 264577 17552 29292357
Gastrointestinal haemorrhage 61.19 11.28 438 264180 79095 29230814
Foetal exposure during pregnancy 60.56 11.28 133 264485 33734 29276175
Bronchopulmonary aspergillosis 59.88 11.28 244 264374 12100 29297809
Erectile dysfunction 58.76 11.28 45 264573 17964 29291945
Acute lymphocytic leukaemia recurrent 58.63 11.28 91 264527 2425 29307484
Sopor 58.61 11.28 13 264605 10921 29298988
Influenza 57.26 11.28 600 264018 41281 29268628
Labelled drug-drug interaction medication error 56.65 11.28 19 264599 12140 29297769
Diffuse large B-cell lymphoma recurrent 56.47 11.28 91 264527 2506 29307403
Hallucination, visual 56.46 11.28 32 264586 14983 29294926
Colitis ulcerative 56.03 11.28 22 264596 12747 29297162
Pain 55.26 11.28 1142 263476 170290 29139619
Neurotoxicity 55.13 11.28 268 264350 14345 29295564
Muscle spasms 54.70 11.28 852 263766 64230 29245679
Bone disorder 54.13 11.28 143 264475 5640 29304269
Pneumonia influenzal 53.90 11.28 63 264555 1267 29308642
Osteolysis 53.47 11.28 68 264550 1497 29308412
Medication error 53.05 11.28 67 264551 21144 29288765
Product use in unapproved indication 52.67 11.28 1080 263538 85795 29224114
Asthenia 52.52 11.28 2391 262227 212859 29097050
Large intestine perforation 52.48 11.28 165 264453 7191 29302718
Chest pain 52.15 11.28 697 263921 111276 29198633
Melaena 52.06 11.28 127 264491 31049 29278860
Haemophagocytic lymphohistiocytosis 52.04 11.28 209 264409 10295 29299614
Spinal cord compression 51.66 11.28 105 264513 3477 29306432
Metabolic acidosis 51.40 11.28 169 264449 37493 29272416
Lower respiratory tract infection 51.14 11.28 409 264209 26093 29283816
Full blood count increased 50.81 11.28 48 264570 746 29309163
Spinal fracture 50.49 11.28 150 264468 6336 29303573
Microsporidia infection 50.00 11.28 41 264577 522 29309387
Eosinophilia 49.43 11.28 76 264542 22085 29287824
Wheezing 49.01 11.28 144 264474 33096 29276813
Ventricular tachycardia 48.85 11.28 79 264539 22495 29287414
Atrial fibrillation 48.45 11.28 1263 263355 104383 29205526
Cushingoid 48.40 11.28 82 264536 2356 29307553
Injection site erythema 47.97 11.28 33 264585 13923 29295986
Pathological fracture 47.51 11.28 106 264512 3749 29306160
Nightmare 46.39 11.28 22 264596 11395 29298514
Infusion related reaction 45.86 11.28 597 264021 43289 29266620
Agitation 45.82 11.28 270 264348 51034 29258875
Fear 45.79 11.28 14 264604 9490 29300419
Adenocarcinoma of colon 45.78 11.28 90 264528 2908 29307001
Gynaecomastia 45.63 11.28 9 264609 8208 29301701
Blood pressure systolic increased 45.57 11.28 50 264568 16795 29293114
Depressed level of consciousness 44.94 11.28 174 264444 36768 29273141
Torsade de pointes 44.80 11.28 4 264614 6657 29303252
Corneal decompensation 44.70 11.28 12 264606 0 29309909
Myelopathy 44.06 11.28 70 264548 1904 29308005
Infective pulmonary exacerbation of cystic fibrosis 44.03 11.28 3 264615 6233 29303676
Loss of consciousness 43.81 11.28 437 264181 73619 29236290
Plasma cell myeloma refractory 43.62 11.28 20 264598 77 29309832
Hepatic cirrhosis 43.53 11.28 39 264579 14405 29295504
H1N1 influenza 43.51 11.28 46 264572 824 29309085
Injection site haemorrhage 42.92 11.28 11 264607 8375 29301534
Akathisia 42.88 11.28 5 264613 6737 29303172
Pemphigoid 42.74 11.28 8 264610 7573 29302336
Product administration error 42.69 11.28 39 264579 14271 29295638
Taste disorder 42.58 11.28 116 264502 4660 29305249
Emotional distress 42.50 11.28 37 264581 13858 29296051
Autonomic neuropathy 42.39 11.28 45 264573 810 29309099
Choroiditis 42.05 11.28 48 264570 940 29308969
Spinal compression fracture 41.93 11.28 135 264483 5959 29303950
Glycosylated haemoglobin increased 41.75 11.28 16 264602 9410 29300499
Injection site swelling 41.69 11.28 16 264602 9401 29300508
Hypogammaglobulinaemia 41.68 11.28 132 264486 5775 29304134
Pulmonary thrombosis 41.22 11.28 141 264477 6424 29303485
Substance abuse 40.85 11.28 6 264612 6781 29303128
Amyloidosis 40.58 11.28 68 264550 1936 29307973
Drug level increased 40.41 11.28 66 264552 18721 29291188
Device issue 40.22 11.28 10 264608 7770 29302139
Acute lymphocytic leukaemia 40.19 11.28 79 264539 2552 29307357
Palpitations 40.02 11.28 153 264465 32451 29277458
Back pain 39.67 11.28 1197 263421 101087 29208822
Underdose 39.57 11.28 29 264589 11840 29298069
Type 2 diabetes mellitus 39.36 11.28 38 264580 13543 29296366
Obstructive airways disorder 39.28 11.28 25 264593 10991 29298918
Neoplasm progression 39.10 11.28 293 264325 18319 29291590
Embolism 38.91 11.28 143 264475 6753 29303156
Exposure during pregnancy 38.76 11.28 14 264604 8540 29301369
Cytomegalovirus infection reactivation 38.68 11.28 90 264528 3274 29306635
Visceral leishmaniasis 38.50 11.28 34 264584 482 29309427
Peripheral motor neuropathy 38.49 11.28 60 264558 1605 29308304
Muscle rigidity 38.44 11.28 18 264600 9393 29300516
Parkinsonism 38.32 11.28 9 264609 7269 29302640
Dehydration 38.30 11.28 1319 263299 113429 29196480
Kidney transplant rejection 38.21 11.28 8 264610 6997 29302912
Delusion 37.92 11.28 27 264591 11189 29298720
Malignant neoplasm of unknown primary site 37.83 11.28 30 264588 363 29309546
Substance-induced psychotic disorder 37.79 11.28 54 264564 1334 29308575
Cardio-respiratory arrest 37.77 11.28 281 264337 50320 29259589
Ocular hypertension 37.58 11.28 39 264579 683 29309226
Rhinocerebral mucormycosis 37.49 11.28 25 264593 226 29309683
Obesity 37.11 11.28 21 264597 9842 29300067
Transplant rejection 37.05 11.28 18 264600 9194 29300715
Meningitis pneumococcal 36.96 11.28 21 264597 138 29309771
Rectal haemorrhage 36.92 11.28 171 264447 34378 29275531
Acute kidney injury 36.73 11.28 1970 262648 263297 29046612
Escherichia sepsis 36.30 11.28 97 264521 3852 29306057
Haematochezia 36.09 11.28 189 264429 36794 29273115
Haematuria 35.94 11.28 239 264379 43900 29266009
Red blood cell sedimentation rate increased 35.93 11.28 11 264607 7450 29302459
Cardiac failure congestive 35.88 11.28 476 264142 76105 29233804
Arteriosclerosis 35.59 11.28 24 264594 10232 29299677
Therapeutic product effect incomplete 35.54 11.28 206 264412 39099 29270810
Dizziness 35.52 11.28 1363 263255 188321 29121588
Compression fracture 35.50 11.28 76 264542 2612 29307297
Panic attack 35.46 11.28 15 264603 8311 29301598
Febrile infection 35.37 11.28 64 264554 1940 29307969
Sexual dysfunction 35.31 11.28 5 264613 5809 29304100
Eczema 35.28 11.28 43 264575 13783 29296126
Hallucination, auditory 35.28 11.28 21 264597 9572 29300337
Device malfunction 35.17 11.28 16 264602 8491 29301418
Dystonia 34.93 11.28 22 264596 9727 29300182
Prescribed overdose 34.87 11.28 17 264601 8666 29301243
Minimal residual disease 34.78 11.28 27 264591 316 29309593
Coronary artery occlusion 34.52 11.28 24 264594 10070 29299839
Joint stiffness 34.47 11.28 21 264597 9452 29300457
Candida infection 34.46 11.28 244 264374 14981 29294928
Peripheral swelling 34.31 11.28 779 263839 62960 29246949
Extrapyramidal disorder 34.16 11.28 28 264590 10803 29299106
Osteoarthritis 34.11 11.28 69 264549 18034 29291875
Injection site reaction 33.96 11.28 30 264588 11158 29298751
Ischaemic cardiomyopathy 33.89 11.28 5 264613 5633 29304276
B precursor type acute leukaemia 33.54 11.28 19 264599 124 29309785
Chronic kidney disease 33.39 11.28 190 264428 36226 29273683
Injection site bruising 33.35 11.28 13 264605 7567 29302342
Paraplegia 32.72 11.28 71 264547 2463 29307446
Bradycardia 32.57 11.28 403 264215 65226 29244683
Injection site mass 32.42 11.28 5 264613 5450 29304459
Nephrolithiasis 32.32 11.28 117 264501 25217 29284692
Hyperlipidaemia 32.29 11.28 39 264579 12551 29297358
Visual acuity reduced 32.28 11.28 236 264382 14640 29295269
Metastases to central nervous system 32.27 11.28 138 264480 6993 29302916
Anhedonia 32.26 11.28 12 264606 7188 29302721
Paranoia 31.81 11.28 25 264593 9852 29300057
Abdominal pain 31.78 11.28 945 263673 134412 29175497
Aplasia 31.66 11.28 94 264524 3969 29305940
Cardiac murmur 31.40 11.28 10 264608 6603 29303306
Road traffic accident 31.34 11.28 57 264561 15504 29294405
Refractory anaemia with an excess of blasts 31.32 11.28 27 264591 370 29309539
Hyperviscosity syndrome 31.29 11.28 20 264598 167 29309742
Diverticular perforation 31.26 11.28 77 264541 2907 29307002
Injection site pruritus 31.26 11.28 7 264611 5842 29304067
Refractory cytopenia with multilineage dysplasia 31.23 11.28 18 264600 122 29309787
Mitral valve incompetence 31.20 11.28 44 264574 13249 29296660
Coronary artery bypass 31.01 11.28 3 264615 4682 29305227
Arthritis 30.97 11.28 117 264501 24902 29285007
Disseminated cryptococcosis 30.86 11.28 45 264573 1133 29308776
C-reactive protein abnormal 30.82 11.28 10 264608 6526 29303383
Cardiac amyloidosis 30.48 11.28 39 264579 864 29309045
Miosis 30.21 11.28 17 264601 7992 29301917
Progressive multifocal leukoencephalopathy 30.13 11.28 156 264462 8563 29301346
Basal cell carcinoma 29.95 11.28 256 264362 16654 29293255
Heart rate decreased 29.87 11.28 118 264500 24794 29285115
Anger 29.82 11.28 32 264586 10858 29299051
Seasonal allergy 29.80 11.28 107 264511 4995 29304914
Pain in extremity 29.79 11.28 756 263862 109677 29200232
Mobility decreased 29.72 11.28 124 264494 25656 29284253
Blood loss anaemia 29.52 11.28 14 264604 7252 29302657
Hypertension 29.43 11.28 806 263812 115808 29194101
Psychotic disorder 29.41 11.28 89 264529 20265 29289644
Vertebral lesion 29.31 11.28 19 264599 163 29309746
Pancreatitis 29.05 11.28 185 264433 34329 29275580
Accidental exposure to product 28.99 11.28 32 264586 10721 29299188
Primary amyloidosis 28.80 11.28 16 264602 100 29309809
Cellulitis orbital 28.76 11.28 23 264595 282 29309627
Drug level decreased 28.69 11.28 10 264608 6237 29303672
Tricuspid valve incompetence 28.65 11.28 20 264598 8374 29301535
Bacterial sepsis 28.65 11.28 100 264518 4603 29305306
Angina pectoris 28.49 11.28 140 264478 27710 29282199
Therapeutic product effect decreased 28.46 11.28 151 264467 29300 29280609
Ulcerative keratitis 28.43 11.28 48 264570 1375 29308534
Hepatitis B reactivation 28.36 11.28 78 264540 3151 29306758
Neutropenic colitis 28.27 11.28 65 264553 2346 29307563
Middle insomnia 28.25 11.28 8 264610 5700 29304209
Benign prostatic hyperplasia 28.24 11.28 38 264580 11672 29298237
Peripheral sensorimotor neuropathy 28.20 11.28 47 264571 1332 29308577
Disseminated aspergillosis 28.00 11.28 26 264592 395 29309514
Haematoma 27.80 11.28 110 264508 23102 29286807
Viral haemorrhagic cystitis 27.72 11.28 38 264580 902 29309007
Atrial septal defect 27.71 11.28 13 264605 6776 29303133
Metapneumovirus infection 27.52 11.28 31 264587 598 29309311
Gastrooesophageal reflux disease 27.45 11.28 167 264451 31329 29278580
Respiratory failure 27.44 11.28 1096 263522 96035 29213874
Herpes zoster 27.39 11.28 399 264219 29653 29280256
Multiple allergies 27.26 11.28 59 264559 2043 29307866
Pneumonia escherichia 27.19 11.28 24 264594 340 29309569
Device leakage 26.99 11.28 4 264614 4491 29305418
Cardiac arrest 26.98 11.28 572 264046 85019 29224890
Priapism 26.93 11.28 4 264614 4484 29305425
Immunosuppressant drug level increased 26.92 11.28 5 264613 4760 29305149
Peritonitis bacterial 26.81 11.28 9 264609 5747 29304162
Faeces discoloured 26.80 11.28 49 264569 13302 29296607
Disturbance in attention 26.64 11.28 100 264518 21324 29288585
Frequent bowel movements 26.60 11.28 26 264592 9213 29300696
Pseudomonas infection 26.39 11.28 177 264441 10675 29299234
Skin striae 26.09 11.28 26 264592 433 29309476
Protein total increased 25.83 11.28 58 264560 2060 29307849
Malaise 25.79 11.28 1166 263452 158436 29151473
Hepatitis C 25.74 11.28 25 264593 8885 29301024
Cholestasis 25.73 11.28 115 264503 23347 29286562
Pulmonary hypertension 25.73 11.28 83 264535 18525 29291384
Alcohol abuse 25.69 11.28 4 264614 4329 29305580
Adrenal insufficiency 25.67 11.28 179 264439 10935 29298974
Diabetic ketoacidosis 25.65 11.28 67 264551 16006 29293903
Knee arthroplasty 25.50 11.28 10 264608 5799 29304110
Product storage error 25.48 11.28 13 264605 6457 29303452
Decreased appetite 25.38 11.28 1565 263053 143777 29166132
Pneumonia viral 25.20 11.28 66 264552 2589 29307320
Pulmonary arterial hypertension 25.09 11.28 18 264600 7431 29302478
Cataract subcapsular 25.05 11.28 23 264595 344 29309565
Liver function test abnormal 24.86 11.28 154 264464 28764 29281145
Blood calcium increased 24.63 11.28 74 264544 3145 29306764
Hypertriglyceridaemia 24.63 11.28 132 264486 7343 29302566
Coombs positive haemolytic anaemia 24.63 11.28 32 264586 720 29309189
Ankylosing spondylitis 24.43 11.28 4 264614 4172 29305737
B-cell lymphoma recurrent 24.40 11.28 29 264589 594 29309315
Pulmonary function test decreased 24.33 11.28 4 264614 4159 29305750
Pneumonitis 24.25 11.28 369 264249 27675 29282234
Differentiation syndrome 24.20 11.28 39 264579 1074 29308835
Cerebral haemorrhage 24.18 11.28 173 264445 31253 29278656
Dyslipidaemia 24.13 11.28 12 264606 6049 29303860
Intestinal perforation 24.12 11.28 139 264479 7947 29301962
Escherichia bacteraemia 24.08 11.28 68 264550 2790 29307119
Vascular pain 24.00 11.28 15 264603 120 29309789
Cerebral venous thrombosis 23.84 11.28 29 264589 609 29309300
Crying 23.84 11.28 9 264609 5342 29304567
Swollen tongue 23.76 11.28 46 264572 12220 29297689
Rectal adenocarcinoma 23.71 11.28 32 264586 748 29309161
Negative pressure pulmonary oedema 23.59 11.28 18 264600 205 29309704
Performance status decreased 23.36 11.28 80 264538 3647 29306262
Blood immunoglobulin M increased 23.29 11.28 17 264601 180 29309729
Hyperhidrosis 23.16 11.28 422 264196 64118 29245791
Arteriosclerosis coronary artery 23.05 11.28 37 264581 10568 29299341
Aspergillus infection 23.04 11.28 168 264450 10413 29299496
Meningitis bacterial 23 11.28 38 264580 1069 29308840
Therapeutic response unexpected 22.97 11.28 26 264592 8612 29301297
Pulmonary congestion 22.92 11.28 48 264570 12388 29297521
Blood pressure measurement 22.84 11.28 16 264602 158 29309751
Lip swelling 22.79 11.28 48 264570 12362 29297547
Heart block congenital 22.74 11.28 10 264608 34 29309875
Multiple organ dysfunction syndrome 22.69 11.28 732 263886 62384 29247525
Complications of transplanted kidney 22.66 11.28 4 264614 3950 29305959
Dysgeusia 22.66 11.28 306 264312 22368 29287541
Staphylococcal bacteraemia 22.65 11.28 124 264494 6955 29302954
Ecthyma 22.63 11.28 22 264596 355 29309554
Nephrogenic systemic fibrosis 22.57 11.28 4 264614 3938 29305971
Second primary malignancy 22.50 11.28 119 264499 6586 29303323
Bacterial infection 22.40 11.28 195 264423 12753 29297156
Keratitis fungal 22.25 11.28 11 264607 52 29309857
Tendonitis 22.24 11.28 23 264595 7938 29301971
Immunosuppression 22.18 11.28 100 264518 5186 29304723
Familial periodic paralysis 22.13 11.28 12 264606 71 29309838
Light chain disease 22.09 11.28 14 264604 115 29309794
JC virus infection 22.09 11.28 51 264567 1846 29308063
Drug reaction with eosinophilia and systemic symptoms 22.07 11.28 153 264465 27839 29282070
Pulmonary mucormycosis 22.05 11.28 26 264592 528 29309381
Blood urea increased 22.00 11.28 154 264464 27958 29281951
Hypocalcaemia 21.95 11.28 282 264336 20383 29289526
Pneumonia bacterial 21.89 11.28 151 264467 9192 29300717
Neoplasm recurrence 21.76 11.28 52 264566 1925 29307984
Inflammation 21.70 11.28 117 264501 22611 29287298
Blood triglycerides increased 21.64 11.28 52 264566 12782 29297127
Rash pruritic 21.61 11.28 300 264318 22063 29287846
Obsessive-compulsive disorder 21.58 11.28 7 264611 4569 29305340
Large intestine polyp 21.57 11.28 16 264602 6493 29303416
Cardiomegaly 21.55 11.28 58 264560 13718 29296191
Fall 21.53 11.28 1332 263286 175846 29134063
Blood creatinine increased 21.51 11.28 588 264030 84514 29225395
Gastric ulcer 21.39 11.28 60 264558 14001 29295908
Nocardiosis 21.33 11.28 71 264547 3189 29306720
Therapy non-responder 21.32 11.28 392 264226 30519 29279390
Syringe issue 21.27 11.28 4 264614 3774 29306135
Salivary hypersecretion 21.16 11.28 21 264597 7388 29302521
Product complaint 21.08 11.28 11 264607 5394 29304515
Cellulitis enterococcal 21.00 11.28 11 264607 60 29309849
Blood immunoglobulin G increased 20.99 11.28 32 264586 839 29309070
Hypoxia 20.98 11.28 564 264054 46815 29263094
Oral candidiasis 20.97 11.28 166 264452 10556 29299353
Paraproteinaemia 20.96 11.28 20 264598 315 29309594
Haematemesis 20.72 11.28 132 264486 24494 29285415
Heart rate irregular 20.68 11.28 55 264563 13062 29296847
Withdrawal syndrome 20.62 11.28 42 264576 10950 29298959
Iron deficiency anaemia 20.59 11.28 30 264588 8912 29300997
Pulmonary fibrosis 20.52 11.28 71 264547 15511 29294398
Blood potassium increased 20.50 11.28 65 264553 14586 29295323
Myocardial ischaemia 20.46 11.28 74 264544 15954 29293955
Disability 20.40 11.28 7 264611 4409 29305500
Cardiac failure chronic 20.04 11.28 17 264601 6450 29303459
Back disorder 20.04 11.28 106 264512 5867 29304042
Periorbital infection 20.01 11.28 13 264605 112 29309797
Angina unstable 19.97 11.28 42 264576 10823 29299086
Taeniasis 19.94 11.28 10 264608 49 29309860
Joint range of motion decreased 19.91 11.28 15 264603 6039 29303870
Electrocardiogram QRS complex prolonged 19.90 11.28 6 264612 4104 29305805
Cardiogenic shock 19.90 11.28 96 264522 19094 29290815
Fungal sepsis 19.89 11.28 30 264588 779 29309130
Hypotony of eye 19.72 11.28 12 264606 91 29309818
Right ventricular failure 19.65 11.28 25 264593 7865 29302044
Hepatic encephalopathy 19.55 11.28 56 264562 12979 29296930
Coronary artery stenosis 19.50 11.28 29 264589 8544 29301365
Sputum discoloured 19.44 11.28 18 264600 6545 29303364
Pruritus 19.40 11.28 851 263767 115998 29193911
Aeromonas infection 19.31 11.28 17 264601 240 29309669
Malignant transformation 19.20 11.28 30 264588 804 29309105
Upper gastrointestinal haemorrhage 19.20 11.28 116 264502 21798 29288111
Foot deformity 19.19 11.28 6 264612 4009 29305900
Blood immunoglobulin A increased 19.09 11.28 18 264600 279 29309630
Pneumoretroperitoneum 19.03 11.28 10 264608 55 29309854
Body tinea 19.03 11.28 10 264608 55 29309854
Hordeolum 19.01 11.28 29 264589 761 29309148
Autoimmune lymphoproliferative syndrome 18.89 11.28 14 264604 152 29309757
Mydriasis 18.86 11.28 16 264602 6069 29303840
Urticaria 18.80 11.28 360 264258 54300 29255609
Hypokinesia 18.74 11.28 24 264594 7530 29302379
Intraocular pressure decreased 18.74 11.28 10 264608 57 29309852
Eosinophil count increased 18.72 11.28 23 264595 7346 29302563
Oral pain 18.70 11.28 145 264473 9162 29300747
Lactose intolerance 18.70 11.28 36 264582 1145 29308764
Influenza like illness 18.68 11.28 135 264483 24335 29285574
Bradykinesia 18.67 11.28 4 264614 3443 29306466
Gallbladder oedema 18.49 11.28 15 264603 188 29309721
Atrial flutter 18.48 11.28 198 264420 13696 29296213
Tubulointerstitial nephritis 18.45 11.28 88 264530 17555 29292354
Sleep disorder due to a general medical condition 18.43 11.28 3 264615 3143 29306766
Depressed mood 18.41 11.28 80 264538 16368 29293541
Respiratory rate increased 18.35 11.28 31 264587 8677 29301232
Gait disturbance 18.22 11.28 508 264110 72841 29237068
Necrotising retinitis 18.21 11.28 28 264590 740 29309169
Chalazion 18.13 11.28 12 264606 107 29309802
Hepatitis cholestatic 18.05 11.28 21 264597 6872 29303037
Human herpesvirus 6 encephalitis 18.04 11.28 15 264603 195 29309714
Oroantral fistula 18.04 11.28 15 264603 195 29309714
Hypothyroidism 18.03 11.28 77 264541 15829 29294080
Diverticulum 18.02 11.28 18 264600 6314 29303595
Haemorrhage 18.01 11.28 289 264329 44783 29265126
Irritability 18.00 11.28 120 264498 22032 29287877
Pneumonia parainfluenzae viral 17.94 11.28 13 264605 136 29309773
Streptococcal bacteraemia 17.76 11.28 44 264574 1667 29308242
Ventricular fibrillation 17.73 11.28 77 264541 15756 29294153
Pneumonia aspiration 17.69 11.28 227 264391 36510 29273399
Varicella zoster virus infection 17.68 11.28 40 264578 1428 29308481
Chronic obstructive pulmonary disease 17.59 11.28 259 264359 40696 29269213
Fungal oesophagitis 17.58 11.28 18 264600 310 29309599
Keratitis bacterial 17.56 11.28 10 264608 66 29309843
Respirovirus test positive 17.56 11.28 10 264608 66 29309843
Abdominal discomfort 17.56 11.28 312 264306 47591 29262318
Muscle spasticity 17.52 11.28 11 264607 4872 29305037
Pneumonia pneumococcal 17.50 11.28 44 264574 1683 29308226
Colitis 17.46 11.28 384 264234 30864 29279045
Clostridium difficile colitis 17.45 11.28 188 264430 13024 29296885
SARS-CoV-2 test positive 17.44 11.28 67 264551 3232 29306677
Exercise tolerance decreased 17.42 11.28 8 264610 4223 29305686
Corneal abscess 17.33 11.28 7 264611 18 29309891
Neutropenic infection 17.31 11.28 37 264581 1270 29308639
Blood stem cell transplant failure 17.27 11.28 20 264598 398 29309511
Blood glucose decreased 17.27 11.28 53 264565 12016 29297893
Gastritis 17.26 11.28 103 264515 19414 29290495
Hiatus hernia 17.23 11.28 21 264597 6731 29303178
Disseminated strongyloidiasis 17.10 11.28 11 264607 93 29309816
Corneal lesion 17.06 11.28 7 264611 19 29309890
Altered state of consciousness 17.05 11.28 106 264512 19783 29290126
Infection reactivation 17.04 11.28 33 264585 1054 29308855
Pneumonia fungal 17.03 11.28 99 264519 5678 29304231
Steroid withdrawal syndrome 17.02 11.28 15 264603 212 29309697
Presyncope 16.97 11.28 80 264538 16009 29293900
Immunoglobulins increased 16.96 11.28 14 264604 180 29309729
Central nervous system vasculitis 16.93 11.28 19 264599 365 29309544
Diabetes mellitus inadequate control 16.86 11.28 54 264564 12080 29297829
Photosensitivity reaction 16.84 11.28 36 264582 9222 29300687
Blood cholesterol increased 16.77 11.28 77 264541 15518 29294391
Meningitis cryptococcal 16.76 11.28 49 264569 2051 29307858
Hypothermia 16.74 11.28 36 264582 9203 29300706
Pericardial haemorrhage 16.72 11.28 3 264615 2928 29306981
Blood pressure diastolic decreased 16.72 11.28 23 264595 6999 29302910
Renal injury 16.68 11.28 42 264576 10160 29299749
Encephalitis brain stem 16.63 11.28 10 264608 74 29309835
Musculoskeletal pain 16.63 11.28 172 264446 28781 29281128
Myoclonus 16.62 11.28 62 264556 13247 29296662
White blood cell count increased 16.55 11.28 236 264382 37280 29272629
Upper respiratory tract infection 16.55 11.28 340 264278 27009 29282900
Restlessness 16.51 11.28 123 264495 22022 29287887
Glioblastoma multiforme 16.50 11.28 25 264593 652 29309257
Gastric perforation 16.49 11.28 50 264568 2136 29307773
Stent placement 16.44 11.28 9 264609 4297 29305612
Electrocardiogram abnormal 16.43 11.28 25 264593 7297 29302612
Flushing 16.43 11.28 357 264261 28635 29281274
Light chain analysis abnormal 16.42 11.28 10 264608 76 29309833
Chromaturia 16.41 11.28 59 264559 12743 29297166
Discomfort 16.41 11.28 72 264546 14691 29295218
Cerebral haematoma 16.37 11.28 9 264609 4287 29305622
Rib fracture 16.34 11.28 180 264438 12538 29297371
Cytomegalovirus infection 16.22 11.28 295 264323 22920 29286989
Posterior capsule rupture 16.20 11.28 6 264612 11 29309898
Needle issue 16.19 11.28 11 264607 4672 29305237
Jaw disorder 16.14 11.28 47 264571 1963 29307946
Testicular germ cell cancer metastatic 16.11 11.28 9 264609 57 29309852
Aspiration bone marrow abnormal 16.09 11.28 11 264607 104 29309805
Mantle cell lymphoma recurrent 16.01 11.28 21 264597 477 29309432
Dyspnoea exertional 15.94 11.28 230 264388 36260 29273649
Choroidal detachment 15.91 11.28 18 264600 349 29309560
Protein total abnormal 15.88 11.28 17 264601 309 29309600
Steroid diabetes 15.85 11.28 42 264576 1659 29308250
Epstein-Barr virus infection reactivation 15.81 11.28 22 264596 530 29309379
Glioblastoma 15.76 11.28 30 264588 946 29308963
Gastritis erosive 15.73 11.28 15 264603 5378 29304531
Seizure 15.70 11.28 677 263941 92446 29217463
Ureteric compression 15.70 11.28 13 264605 168 29309741
Herpes simplex reactivation 15.67 11.28 8 264610 41 29309868
Skin plaque 15.67 11.28 7 264611 3755 29306154
Refeeding syndrome 15.66 11.28 7 264611 25 29309884
Pallor 15.56 11.28 117 264501 20907 29289002
Stem cell transplant 15.51 11.28 46 264572 1941 29307968
Lentigo maligna 15.50 11.28 17 264601 318 29309591
Umbilical hernia 15.48 11.28 7 264611 3728 29306181
Orthopnoea 15.38 11.28 11 264607 4549 29305360
Non-small cell lung cancer 15.32 11.28 60 264558 2921 29306988
Post procedural complication 15.31 11.28 45 264573 10344 29299565
Joint injury 15.25 11.28 24 264594 6909 29303000
Tumour perforation 15.23 11.28 15 264603 246 29309663
Disseminated coccidioidomycosis 15.21 11.28 5 264613 5 29309904
Device related infection 15.21 11.28 210 264408 15426 29294483
Exposed bone in jaw 15.20 11.28 38 264580 1448 29308461
Sternal fracture 15.17 11.28 23 264595 600 29309309
Glaucoma 15.13 11.28 97 264521 5760 29304149
Hyperbilirubinaemia 15.11 11.28 202 264416 14732 29295177
Disorientation 15.10 11.28 180 264438 29335 29280574
Enterococcal infection 15.08 11.28 126 264492 8142 29301767
Incorrect route of product administration 15.06 11.28 48 264570 10753 29299156
Renal cyst 15.01 11.28 30 264588 7877 29302032
Panophthalmitis 14.97 11.28 6 264612 15 29309894
Hypertransaminasaemia 14.96 11.28 68 264550 3538 29306371
Mental disorder 14.92 11.28 62 264556 12843 29297066
Granulocytopenia 14.92 11.28 19 264599 5975 29303934
Fascial infection 14.90 11.28 4 264614 0 29309909
VIIIth nerve lesion 14.90 11.28 4 264614 0 29309909
Syncope 14.90 11.28 586 264032 80785 29229124
Hepatocellular carcinoma 14.88 11.28 25 264593 7013 29302896
Cryptococcal meningoencephalitis 14.88 11.28 11 264607 119 29309790
Corneal degeneration 14.87 11.28 7 264611 29 29309880
Duodenal ulcer haemorrhage 14.86 11.28 11 264607 4468 29305441
Catatonia 14.78 11.28 11 264607 4457 29305452
Acute lymphocytic leukaemia refractory 14.76 11.28 10 264608 93 29309816
Haemodialysis 14.76 11.28 43 264575 9911 29299998
Weight fluctuation 14.74 11.28 74 264544 4012 29305897
Productive cough 14.73 11.28 194 264424 31065 29278844
Secondary immunodeficiency 14.69 11.28 17 264601 338 29309571
Staphylococcal sepsis 14.57 11.28 132 264486 8730 29301179
Atypical haemolytic uraemic syndrome 14.56 11.28 12 264606 154 29309755
Guillain-Barre syndrome 14.47 11.28 86 264532 4972 29304937
Body temperature decreased 14.44 11.28 48 264570 10616 29299293
Recalled product administered 14.44 11.28 19 264599 433 29309476
Alcohol use 14.41 11.28 5 264613 3127 29306782
Intestinal atresia 14.40 11.28 9 264609 72 29309837
Pregnancy of partner 14.39 11.28 16 264602 304 29309605
Prescribed underdose 14.39 11.28 30 264588 7756 29302153
Coordination abnormal 14.38 11.28 26 264592 7088 29302821
Toxicity to various agents 14.36 11.28 1348 263270 172313 29137596
Euglycaemic diabetic ketoacidosis 14.35 11.28 3 264615 2627 29307282
Systemic candida 14.32 11.28 56 264562 2724 29307185
Ejection fraction decreased 14.30 11.28 84 264534 15894 29294015
Nicotinic acid deficiency 14.30 11.28 9 264609 73 29309836
Hepatitis 14.30 11.28 118 264500 20665 29289244
Device dislocation 14.28 11.28 79 264539 4448 29305461
Abnormal dreams 14.25 11.28 25 264593 6895 29303014
Hypoalbuminaemia 14.25 11.28 148 264470 10157 29299752
Hepatic steatosis 14.23 11.28 77 264541 14869 29295040
Speech disorder 14.21 11.28 138 264480 23378 29286531
Hypercholesterolaemia 14.14 11.28 27 264591 7211 29302698
Pneumonia respiratory syncytial viral 14.14 11.28 26 264592 798 29309111
B-cell type acute leukaemia 14.13 11.28 15 264603 270 29309639
Corneal perforation 14.12 11.28 12 264606 161 29309748
Colorectal adenocarcinoma 14.08 11.28 13 264605 196 29309713
Bundle branch block right 14.07 11.28 24 264594 6693 29303216
Lower gastrointestinal haemorrhage 14.07 11.28 33 264585 8180 29301729
Cerebrovascular accident 14.06 11.28 554 264064 76357 29233552
Product dispensing error 14.03 11.28 17 264601 5463 29304446
Congenital herpes simplex infection 14.01 11.28 7 264611 34 29309875
VIth nerve disorder 13.96 11.28 6 264612 19 29309890
Injection site induration 13.93 11.28 3 264615 2573 29307336
Exposure to toxic agent 13.93 11.28 3 264615 2572 29307337
Vitreous loss 13.92 11.28 5 264613 8 29309901
Paraesthesia 13.92 11.28 602 264016 53243 29256666
Tooth deposit 13.90 11.28 9 264609 77 29309832
Electrocardiogram Q waves 13.85 11.28 7 264611 35 29309874
Drug specific antibody present 13.82 11.28 3 264615 2558 29307351
Clostridium difficile infection 13.81 11.28 212 264406 15929 29293980
Expired product administered 13.80 11.28 4 264614 2807 29307102
Amyotrophy 13.79 11.28 18 264600 407 29309502
Dysphonia 13.79 11.28 245 264373 18951 29290958
Vocal cord paresis 13.77 11.28 10 264608 105 29309804
Haematoma muscle 13.74 11.28 28 264590 929 29308980
Glomerular filtration rate decreased 13.74 11.28 53 264565 11213 29298696
Unresponsive to stimuli 13.73 11.28 151 264467 24975 29284934
Post procedural hypotension 13.67 11.28 8 264610 56 29309853
Duodenal ulcer 13.63 11.28 40 264578 9198 29300711
Rhinovirus infection 13.61 11.28 61 264557 3155 29306754
Renal amyloidosis 13.55 11.28 8 264610 57 29309852
Meningoradiculitis 13.54 11.28 7 264611 37 29309872
Hypopyon 13.53 11.28 16 264602 326 29309583
Hyperreflexia 13.51 11.28 4 264614 2768 29307141
Developmental delay 13.48 11.28 3 264615 2515 29307394
Dysarthria 13.44 11.28 195 264423 30716 29279193
Pharyngeal oedema 13.43 11.28 19 264599 5715 29304194
Spinal disorder 13.39 11.28 67 264551 3628 29306281
Escherichia infection 13.38 11.28 105 264513 6659 29303250
C-reactive protein increased 13.30 11.28 298 264320 43965 29265944
Vitamin D deficiency 13.27 11.28 18 264600 5511 29304398
VIth nerve paralysis 13.27 11.28 24 264594 727 29309182
Psychomotor retardation 13.27 11.28 5 264613 2971 29306938
Central nervous system leukaemia 13.23 11.28 14 264604 251 29309658
Enterocolitis infectious 13.23 11.28 33 264585 1256 29308653
Autologous haematopoietic stem cell transplant 13.22 11.28 5 264613 10 29309899
Metastatic malignant melanoma 13.21 11.28 41 264577 1774 29308135
Blood culture positive 13.21 11.28 78 264540 4499 29305410
Squamous cell carcinoma of head and neck 13.17 11.28 11 264607 144 29309765
Blood pressure decreased 13.15 11.28 308 264310 45169 29264740
Superior sagittal sinus thrombosis 13.14 11.28 14 264604 253 29309656
Head injury 13.12 11.28 87 264531 15994 29293915
Drug-induced liver injury 13.12 11.28 127 264491 21528 29288381
POEMS syndrome 13.11 11.28 7 264611 40 29309869
Hypercalcaemia of malignancy 13.10 11.28 12 264606 179 29309730
Aplasia pure red cell 13.06 11.28 18 264600 5473 29304436
Status epilepticus 13.02 11.28 51 264567 10743 29299166
Oropharyngeal candidiasis 13.01 11.28 22 264596 631 29309278
Capillary leak syndrome 13.00 11.28 42 264576 1857 29308052
Peripheral vascular disorder 12.98 11.28 13 264605 4554 29305355
Joint effusion 12.97 11.28 11 264607 4173 29305736
Acidosis 12.93 11.28 44 264574 9661 29300248
Transitional cell cancer of the renal pelvis and ureter 12.91 11.28 6 264612 24 29309885
Impaired work ability 12.91 11.28 19 264599 5621 29304288
Diabetic hyperosmolar coma 12.90 11.28 16 264602 343 29309566
Spinal pain 12.84 11.28 81 264537 4783 29305126
Corneal deposits 12.83 11.28 12 264606 184 29309725
Personality change due to a general medical condition 12.83 11.28 7 264611 42 29309867
Leukoencephalopathy 12.74 11.28 67 264551 3700 29306209
Anal inflammation 12.71 11.28 15 264603 305 29309604
Feeling cold 12.70 11.28 41 264577 9150 29300759
Plasma cells present 12.69 11.28 4 264614 3 29309906
Ascites 12.64 11.28 241 264377 36378 29273531
Mucosal haemorrhage 12.63 11.28 36 264582 1485 29308424
Thinking abnormal 12.62 11.28 17 264601 5219 29304690
Basosquamous carcinoma of skin 12.62 11.28 5 264613 12 29309897
Peritumoural oedema 12.62 11.28 5 264613 12 29309897
Gingivitis 12.60 11.28 56 264562 2886 29307023
Ventricular septal defect 12.59 11.28 8 264610 3521 29306388
Bone sequestrum 12.58 11.28 19 264599 494 29309415
Red blood cell count decreased 12.57 11.28 309 264309 25293 29284616
Lymphocytic leukaemia 12.57 11.28 11 264607 154 29309755
Post procedural infection 12.53 11.28 12 264606 4293 29305616
Sarcoidosis 12.52 11.28 4 264614 2636 29307273
Hip deformity 12.51 11.28 9 264609 93 29309816
Osteomyelitis 12.48 11.28 182 264436 13527 29296382
Pulmonary sepsis 12.43 11.28 41 264577 1833 29308076
Macular fibrosis 12.42 11.28 16 264602 357 29309552
Hepatic cytolysis 12.42 11.28 36 264582 8311 29301598
Renal disorder 12.41 11.28 277 264341 22318 29287591
Cholelithiasis 12.40 11.28 107 264511 18565 29291344
Lymphadenitis 12.35 11.28 37 264581 1570 29308339
Injury corneal 12.34 11.28 5 264613 13 29309896
Pseudomonal bacteraemia 12.29 11.28 27 264591 945 29308964
Dysuria 12.20 11.28 135 264483 22305 29287604
Subdural haematoma 12.19 11.28 104 264514 18089 29291820
Listeriosis 12.17 11.28 26 264592 892 29309017
Epstein-Barr virus associated lymphoma 12.17 11.28 20 264598 560 29309349
Platelet disorder 12.17 11.28 33 264585 1322 29308587
Concomitant disease aggravated 12.16 11.28 16 264602 4962 29304947
Lymphocyte count decreased 12.13 11.28 241 264377 19030 29290879
Radiation necrosis 12.12 11.28 9 264609 98 29309811
Normochromic normocytic anaemia 12.11 11.28 9 264609 3649 29306260
Neck pain 12.07 11.28 128 264490 21319 29288590
Interstitial lung disease 12.06 11.28 409 264209 57309 29252600
Transformation to acute myeloid leukaemia 12.02 11.28 22 264596 673 29309236
Somnambulism 11.98 11.28 5 264613 2793 29307116
Oropharyngeal discomfort 11.98 11.28 50 264568 2506 29307403
Systemic lupus erythematosus 11.97 11.28 4 264614 2562 29307347
Hypertonia 11.95 11.28 10 264608 3819 29306090
Acute myocardial infarction 11.89 11.28 336 264282 48102 29261807
Snoring 11.88 11.28 5 264613 2779 29307130
Bacillus test positive 11.87 11.28 6 264612 30 29309879
Gastrointestinal toxicity 11.86 11.28 44 264574 2087 29307822
Nerve injury 11.86 11.28 56 264562 2961 29306948
Cataract cortical 11.85 11.28 8 264610 74 29309835
Squamous cell carcinoma of the hypopharynx 11.83 11.28 5 264613 15 29309894
Gastrointestinal wall thinning 11.83 11.28 5 264613 15 29309894
Eye pain 11.80 11.28 157 264461 11438 29298471
Therapy responder 11.75 11.28 11 264607 169 29309740
Nasal congestion 11.74 11.28 110 264508 18769 29291140
Aspiration 11.71 11.28 49 264569 10131 29299778
High density lipoprotein decreased 11.71 11.28 6 264612 2973 29306936
Memory impairment 11.69 11.28 243 264375 36227 29273682
Bronchiectasis 11.65 11.28 26 264592 6559 29303350
Hyperglycaemic hyperosmolar nonketotic syndrome 11.62 11.28 28 264590 1042 29308867
Corneal infiltrates 11.60 11.28 10 264608 137 29309772
Shock haemorrhagic 11.60 11.28 45 264573 9506 29300403
Janeway lesion 11.59 11.28 5 264613 16 29309893
Hypogeusia 11.57 11.28 25 264593 865 29309044
Hyponatraemia 11.54 11.28 491 264127 67142 29242767
Enterococcal bacteraemia 11.50 11.28 35 264583 1498 29308411
Pneumonia cryptococcal 11.49 11.28 23 264595 753 29309156
Bladder cancer 11.49 11.28 49 264569 10078 29299831
Adenoviral hepatitis 11.48 11.28 12 264606 212 29309697
Aortic aneurysm 11.47 11.28 24 264594 6196 29303713
Neoplasm 11.43 11.28 70 264548 4091 29305818
Aortic valve incompetence 11.36 11.28 17 264601 4996 29304913
Superficial spreading melanoma stage II 11.29 11.28 4 264614 6 29309903

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 3569.51 10.22 2716 418139 43359 64034518
Neutropenia 2313.24 10.22 4934 415921 234690 63843187
Febrile neutropenia 2092.77 10.22 4103 416752 183554 63894323
Neuropathy peripheral 1939.45 10.22 3054 417801 114471 63963406
Thrombocytopenia 1918.11 10.22 4395 416460 219406 63858471
Pneumonia 1538.04 10.22 7459 413396 552117 63525760
Completed suicide 1286.33 10.22 39 420816 224375 63853502
Plasma cell myeloma recurrent 884.92 10.22 462 420393 3603 64074274
Platelet count decreased 827.67 10.22 2691 418164 165020 63912857
Pancytopenia 759.55 10.22 2357 418498 140952 63936925
Rheumatoid arthritis 745.51 10.22 96 420759 164198 63913679
Deep vein thrombosis 702.47 10.22 1880 418975 103302 63974575
Sepsis 677.43 10.22 3137 417718 227204 63850673
Drug abuse 639.19 10.22 62 420793 132312 63945565
Disease progression 626.86 10.22 2192 418663 139488 63938389
Arthralgia 617.00 10.22 1222 419633 441038 63636839
Neutrophil count decreased 585.78 10.22 1448 419407 75748 64002129
Pulmonary embolism 569.51 10.22 2172 418683 144184 63933693
Unevaluable event 560.01 10.22 1103 419752 49386 64028491
White blood cell count decreased 540.78 10.22 2251 418604 155586 63922291
Plasmacytoma 533.27 10.22 326 420529 3544 64074333
Neutropenic sepsis 528.07 10.22 704 420151 22568 64055309
Intentional overdose 517.27 10.22 15 420840 89929 63987948
Drug hypersensitivity 491.36 10.22 496 420359 237319 63840558
Pain 485.78 10.22 1914 418941 551597 63526280
Septic shock 471.11 10.22 1637 419218 103800 63974077
Leukopenia 453.31 10.22 1573 419282 99669 63978208
Anaemia 451.36 10.22 4102 416753 374578 63703299
Pyrexia 450.30 10.22 5591 415264 553053 63524824
Injection site pain 441.13 10.22 94 420761 111314 63966563
Overdose 433.83 10.22 251 420604 159315 63918562
Mucosal inflammation 432.18 10.22 1133 419722 61451 64016426
Death 431.42 10.22 4928 415927 477777 63600100
Off label use 430.12 10.22 6140 414715 626666 63451211
Cytopenia 410.78 10.22 506 420349 14965 64062912
Tumour lysis syndrome 407.60 10.22 566 420289 18874 64059003
Drug interaction 403.95 10.22 1126 419729 360957 63716920
Full blood count decreased 402.79 10.22 609 420246 21973 64055904
Contraindicated product administered 386.18 10.22 112 420743 107717 63970160
Constipation 376.33 10.22 2674 418181 226663 63851214
Polyneuropathy 371.25 10.22 548 420307 19346 64058531
Synovitis 369.74 10.22 95 420760 98995 63978882
Joint swelling 360.42 10.22 529 420326 214853 63863024
Diarrhoea 353.87 10.22 6644 414211 716060 63361817
Systemic lupus erythematosus 350.33 10.22 46 420809 77566 64000311
Arthropathy 349.64 10.22 176 420679 120791 63957086
Malignant neoplasm progression 343.65 10.22 1554 419301 111317 63966560
Therapeutic product effect decreased 342.25 10.22 162 420693 115189 63962688
Plasma cell leukaemia 330.89 10.22 174 420681 1379 64076498
Drug ineffective 329.83 10.22 3704 417151 836543 63241334
Thrombosis 327.84 10.22 1111 419744 69531 64008346
Pneumocystis jirovecii pneumonia 327.50 10.22 621 420234 27013 64050864
Suicide attempt 299.99 10.22 51 420804 70956 64006921
Hand deformity 298.74 10.22 31 420824 62740 64015137
Headache 296.73 10.22 2130 418725 527337 63550540
Abdominal discomfort 294.15 10.22 459 420396 181863 63896014
Condition aggravated 292.07 10.22 1343 419512 371083 63706794
Peripheral sensory neuropathy 289.04 10.22 364 420491 11014 64066863
Psoriasis 280.75 10.22 62 420793 71641 64006236
Pemphigus 276.31 10.22 35 420820 60666 64017211
Myelodysplastic syndrome 270.78 10.22 573 420282 27006 64050871
Musculoskeletal stiffness 269.37 10.22 244 420611 122962 63954915
Bone marrow failure 249.31 10.22 784 420071 47168 64030709
Osteonecrosis 247.05 10.22 560 420295 27669 64050208
Posterior reversible encephalopathy syndrome 240.81 10.22 490 420365 22456 64055421
Injection site erythema 238.38 10.22 82 420773 70718 64007159
Haematotoxicity 233.11 10.22 350 420505 12546 64065331
Depression 227.91 10.22 539 420316 182752 63895125
Anti-cyclic citrullinated peptide antibody positive 222.17 10.22 30 420825 49532 64028345
Endophthalmitis 219.43 10.22 220 420635 5145 64072732
Drug intolerance 215.74 10.22 576 420279 187416 63890461
Febrile bone marrow aplasia 212.83 10.22 312 420543 10943 64066934
COVID-19 pneumonia 210.73 10.22 383 420472 16121 64061756
Suicidal ideation 210.71 10.22 85 420770 66457 64011420
Glossodynia 207.56 10.22 81 420774 64615 64013262
Swelling 200.08 10.22 470 420385 159748 63918129
Strongyloidiasis 195.76 10.22 162 420693 2928 64074949
Stress 195.51 10.22 75 420780 60459 64017418
Intentional product misuse 193.15 10.22 116 420739 72179 64005698
Product use in unapproved indication 188.73 10.22 1871 418984 174747 63903130
Inappropriate schedule of product administration 187.50 10.22 195 420660 92091 63985786
Squamous cell carcinoma of skin 186.35 10.22 302 420553 11574 64066303
Loss of personal independence in daily activities 180.30 10.22 126 420729 72328 64005549
Therapy partial responder 177.96 10.22 273 420582 9975 64067902
Pain in extremity 175.87 10.22 1206 419649 301879 63775998
Multiple sclerosis relapse 174.94 10.22 29 420826 41106 64036771
Cytomegalovirus chorioretinitis 173.15 10.22 186 420669 4726 64073151
Arthritis 172.65 10.22 175 420680 83639 63994238
Rhabdomyolysis 169.80 10.22 209 420646 91517 63986360
Bronchopulmonary aspergillosis 169.66 10.22 381 420474 18704 64059173
Wound 168.86 10.22 150 420705 76327 64001550
Hyperglycaemia 166.82 10.22 814 420041 60154 64017723
Discomfort 166.45 10.22 169 420686 80709 63997168
Mucormycosis 166.39 10.22 222 420633 7119 64070758
Wrong technique in product usage process 165.67 10.22 110 420745 64864 64013013
Injection site reaction 164.23 10.22 50 420805 46614 64031263
Injection site swelling 161.38 10.22 36 420819 41317 64036560
Psoriatic arthropathy 158.54 10.22 43 420812 43238 64034639
Haemophagocytic lymphohistiocytosis 154.82 10.22 350 420505 17259 64060618
Cytokine release syndrome 153.96 10.22 387 420468 20442 64057435
Injection site pruritus 153.65 10.22 30 420825 37796 64040081
Light chain analysis increased 152.19 10.22 99 420756 1209 64076668
Rheumatoid factor positive 149.99 10.22 24 420831 34914 64042963
Anxiety 149.68 10.22 746 420109 201903 63875974
Multiple organ dysfunction syndrome 149.24 10.22 1153 419702 100260 63977617
Neurotoxicity 147.92 10.22 454 420401 26950 64050927
Injection site bruising 147.42 10.22 29 420826 36344 64041533
Intentional self-injury 147.24 10.22 11 420844 29033 64048844
Acute lymphocytic leukaemia recurrent 146.42 10.22 155 420700 3871 64074006
Blood pressure fluctuation 146.06 10.22 78 420777 51793 64026084
Dehydration 144.56 10.22 2099 418756 214664 63863213
Respiratory failure 144.32 10.22 1648 419207 159535 63918342
Asthma 142.09 10.22 252 420603 94973 63982904
Sleep disorder due to general medical condition, insomnia type 138.93 10.22 8 420847 26262 64051615
Weight increased 137.96 10.22 821 420034 212527 63865350
Osteoarthritis 137.70 10.22 126 420729 63210 64014667
Bacteraemia 137.11 10.22 437 420418 26474 64051403
Injury 135.86 10.22 100 420755 55892 64021985
Hypoglycaemia 135.83 10.22 236 420619 89656 63988221
Mobility decreased 135.59 10.22 219 420636 85621 63992256
Intraocular pressure increased 134.20 10.22 214 420641 8088 64069789
Hiccups 134.15 10.22 215 420640 8161 64069716
Pericarditis 133.99 10.22 126 420729 62390 64015487
Lymphopenia 132.88 10.22 419 420436 25238 64052639
Monoclonal immunoglobulin present 131.54 10.22 77 420778 768 64077109
Flushing 130.43 10.22 920 419935 77728 64000149
Irritable bowel syndrome 128.01 10.22 42 420813 37327 64040550
Large intestine perforation 127.35 10.22 265 420590 12339 64065538
COVID-19 126.12 10.22 792 420063 64348 64013529
Muscle injury 125.92 10.22 13 420842 26424 64051453
Blood pressure increased 125.23 10.22 639 420216 171913 63905964
Myelosuppression 124.18 10.22 390 420465 23440 64054437
Parainfluenzae virus infection 124.08 10.22 154 420701 4589 64073288
Treatment failure 122.84 10.22 373 420482 116443 63961434
C-reactive protein abnormal 122.37 10.22 21 420834 29026 64048851
Hospitalisation 121.50 10.22 189 420666 75018 64002859
Hepatic enzyme increased 121.44 10.22 437 420418 129506 63948371
Nasopharyngitis 120.78 10.22 766 420089 195307 63882570
Bone pain 120.15 10.22 621 420234 46951 64030926
Pneumonitis 117.34 10.22 643 420212 49722 64028155
Metastases to central nervous system 115.12 10.22 270 420585 13642 64064235
Acute myeloid leukaemia 113.62 10.22 416 420439 27047 64050830
Knee arthroplasty 112.68 10.22 20 420835 26979 64050898
Drug withdrawal syndrome 111.07 10.22 33 420822 31258 64046619
Atrial fibrillation 110.97 10.22 1649 419206 169440 63908437
Helicobacter infection 110.51 10.22 56 420799 38306 64039571
Hypofibrinogenaemia 110.11 10.22 92 420763 1686 64076191
Coronary artery disease 109.43 10.22 140 420715 60293 64017584
Poisoning 108.91 10.22 9 420846 21870 64056007
Abortion spontaneous 108.55 10.22 17 420838 25126 64052751
Somnolence 107.55 10.22 832 420023 202813 63875064
Myalgia 107.53 10.22 601 420254 158016 63919861
Osteolysis 105.66 10.22 110 420745 2693 64075184
Fatigue 104.79 10.22 5925 414930 742805 63335072
Sedation 104.61 10.22 71 420784 41391 64036486
Maternal exposure during pregnancy 104.54 10.22 301 420554 95583 63982294
Sinusitis 103.85 10.22 544 420311 145384 63932493
Fall 103.75 10.22 2006 418849 414820 63663057
Cytomegalovirus infection reactivation 103.71 10.22 156 420699 5600 64072277
Blood creatine phosphokinase increased 103.62 10.22 138 420717 58420 64019457
Incorrect dose administered 102.72 10.22 148 420707 60617 64017260
Coma 102.28 10.22 266 420589 87349 63990528
Fibromyalgia 101.67 10.22 53 420802 35678 64042199
Osteonecrosis of jaw 101.35 10.22 521 420334 39304 64038573
Corneal oedema 101.23 10.22 99 420756 2244 64075633
Neuroleptic malignant syndrome 101.15 10.22 20 420835 24976 64052901
Sopor 98.71 10.22 35 420820 29626 64048251
Lactic acidosis 97.61 10.22 156 420699 61254 64016623
Hypoxia 97.56 10.22 941 419914 87208 63990669
Cytomegalovirus infection 96.31 10.22 489 420366 36710 64041167
Red blood cell sedimentation rate increased 95.50 10.22 42 420813 31193 64046684
Product prescribing error 95.02 10.22 56 420799 35213 64042664
Respiratory tract infection 94.94 10.22 489 420366 36918 64040959
Myocardial infarction 93.98 10.22 664 420191 165157 63912720
Aspergillus infection 93.72 10.22 277 420578 16102 64061775
Cardiac amyloidosis 93.44 10.22 76 420779 1339 64076538
Surgery 92.69 10.22 34 420821 28179 64049698
International normalised ratio increased 92.68 10.22 240 420615 78927 63998950
Therapeutic product effect incomplete 91.46 10.22 356 420499 103126 63974751
Blood pressure systolic increased 91.17 10.22 113 420742 49340 64028537
Migraine 89.80 10.22 170 420685 62507 64015370
Myelopathy 88.26 10.22 119 420736 3855 64074022
Hypercalcaemia 87.75 10.22 422 420433 30994 64046883
Injection site haemorrhage 87.28 10.22 25 420830 24253 64053624
Diffuse large B-cell lymphoma recurrent 86.92 10.22 105 420750 3041 64074836
Duodenal ulcer perforation 86.41 10.22 60 420795 34565 64043312
Embolism 85.93 10.22 223 420632 12012 64065865
Device issue 85.82 10.22 21 420834 22627 64055250
Venoocclusive liver disease 85.75 10.22 197 420658 9818 64068059
Gait disturbance 85.51 10.22 715 420140 171440 63906437
Acute lymphocytic leukaemia 85.30 10.22 123 420732 4248 64073629
Product dose omission issue 84.91 10.22 836 420019 193911 63883966
Aplasia 84.53 10.22 158 420697 6795 64071082
Secondary immunodeficiency 83.70 10.22 96 420759 2628 64075249
Malaise 83.66 10.22 1958 418897 394289 63683588
Amyloidosis 83.65 10.22 92 420763 2402 64075475
Laboratory test abnormal 83.65 10.22 345 420510 23718 64054159
Peripheral motor neuropathy 83.48 10.22 100 420755 2870 64075007
Wheezing 83.48 10.22 259 420596 80320 63997557
Electrocardiogram QT prolonged 83.28 10.22 254 420601 79194 63998683
Palpitations 82.73 10.22 375 420480 104113 63973764
Spinal cord compression 82.73 10.22 140 420715 5563 64072314
Asthenia 82.46 10.22 3496 417359 424548 63653329
Folliculitis 82.10 10.22 47 420808 30030 64047847
Febrile infection 82.08 10.22 98 420757 2803 64075074
Pneumonia influenzal 81.09 10.22 91 420764 2431 64075446
Contusion 80.98 10.22 425 420430 113540 63964337
Anaphylactic shock 80.85 10.22 402 420453 29926 64047951
Clostridium difficile colitis 80.65 10.22 372 420483 26851 64051026
Colitis 79.67 10.22 655 420200 58019 64019858
Sleep apnoea syndrome 78.09 10.22 49 420806 29783 64048094
Osteoporosis 77.73 10.22 96 420759 41984 64035893
Pathological fracture 76.96 10.22 177 420678 8828 64069049
Respiratory arrest 75.66 10.22 144 420711 52841 64025036
Diffuse large B-cell lymphoma refractory 75.56 10.22 61 420794 1063 64076814
Gastrooesophageal reflux disease 74.78 10.22 284 420571 82859 63995018
Medication error 74.72 10.22 132 420723 49834 64028043
Injection site warmth 74.72 10.22 3 420852 13459 64064418
Candida infection 74.44 10.22 403 420452 31016 64046861
Serotonin syndrome 74.27 10.22 88 420767 39194 64038683
Impaired healing 74.15 10.22 179 420676 60294 64017583
Alopecia 74.01 10.22 707 420148 164983 63912894
Joint stiffness 72.85 10.22 55 420800 30349 64047528
Neoplasm progression 72.51 10.22 487 420368 40477 64037400
Pseudomonal sepsis 72.43 10.22 125 420730 5047 64072830
Accidental exposure to product 72.25 10.22 41 420814 26323 64051554
Nasal congestion 72.04 10.22 178 420677 59480 64018397
Hypertriglyceridaemia 71.40 10.22 197 420658 11008 64066869
Substance-induced psychotic disorder 71.35 10.22 89 420766 2666 64075211
Dizziness 71.11 10.22 2201 418654 427962 63649915
Colitis ulcerative 70.35 10.22 31 420824 22997 64054880
Drug dependence 69.21 10.22 69 420786 33243 64044634
Product substitution issue 68.78 10.22 16 420839 17845 64060032
Pruritus 68.61 10.22 1534 419321 310866 63767011
Accidental overdose 68.03 10.22 71 420784 33486 64044391
Adenocarcinoma of colon 67.93 10.22 118 420737 4790 64073087
Aggression 67.46 10.22 124 420731 46108 64031769
Blister 66.86 10.22 286 420569 80681 63997196
Treatment noncompliance 66.73 10.22 113 420742 43369 64034508
Feeling abnormal 66.72 10.22 554 420301 133048 63944829
Autonomic neuropathy 66.20 10.22 67 420788 1585 64076292
Escherichia bacteraemia 65.96 10.22 123 420732 5280 64072597
Pulmonary arterial hypertension 65.94 10.22 42 420813 25325 64052552
Hepatitis B reactivation 65.66 10.22 116 420739 4773 64073104
Pregnancy 65.48 10.22 27 420828 20838 64057039
Hip arthroplasty 64.82 10.22 29 420826 21322 64056555
Choroiditis 64.75 10.22 55 420800 1032 64076845
Tenosynovitis 64.47 10.22 3 420852 11830 64066047
Hyperviscosity syndrome 64.33 10.22 36 420819 327 64077550
Parkinsonism 63.70 10.22 9 420846 14364 64063513
Injection site mass 63.54 10.22 17 420838 17253 64060624
Decreased appetite 62.60 10.22 2334 418521 278955 63798922
Musculoskeletal pain 62.42 10.22 295 420560 80999 63996878
Product quality issue 61.60 10.22 62 420793 29737 64048140
Malignant neoplasm of unknown primary site 61.09 10.22 44 420811 641 64077236
Plasma cell myeloma refractory 60.95 10.22 24 420831 86 64077791
Labelled drug-drug interaction medication error 60.90 10.22 34 420821 22028 64055849
Brain oedema 60.55 10.22 295 420560 21780 64056097
Glycosylated haemoglobin increased 60.41 10.22 15 420840 16004 64061873
Bone lesion 60.30 10.22 115 420740 5022 64072855
Sleep disorder 59.68 10.22 195 420660 59514 64018363
Refractory cytopenia with multilineage dysplasia 59.55 10.22 31 420824 240 64077637
Hypokalaemia 59.51 10.22 1122 419733 120781 63957096
Inflammation 59.40 10.22 222 420633 65078 64012799
Obesity 59.24 10.22 30 420825 20532 64057345
Bacterial infection 59.09 10.22 320 420535 24630 64053247
Bacterial sepsis 58.75 10.22 142 420713 7315 64070562
Hyperkalaemia 58.23 10.22 403 420452 100726 63977151
Ill-defined disorder 57.56 10.22 126 420729 43926 64033951
Foot deformity 57.50 10.22 18 420837 16486 64061391
Pulmonary thrombosis 57.45 10.22 175 420680 10343 64067534
Heart rate decreased 57.03 10.22 177 420678 54890 64022987
Ageusia 56.93 10.22 209 420646 13604 64064273
Diverticular perforation 56.69 10.22 113 420742 5100 64072777
Corneal decompensation 56.38 10.22 18 420837 27 64077850
Systemic candida 56.14 10.22 114 420741 5215 64072662
Joint range of motion decreased 56.06 10.22 28 420827 19315 64058562
Influenza like illness 55.97 10.22 210 420645 61492 64016385
Infective pulmonary exacerbation of cystic fibrosis 55.67 10.22 6 420849 11790 64066087
Hepatic cirrhosis 55.18 10.22 54 420801 26244 64051633
Blood pressure diastolic decreased 55.18 10.22 39 420816 22262 64055615
Intestinal perforation 55.17 10.22 222 420633 15091 64062786
Rhinovirus infection 54.83 10.22 123 420732 6033 64071844
Hallucination 54.80 10.22 266 420589 72522 64005355
Herpes simplex encephalitis 54.50 10.22 40 420815 601 64077276
Oral candidiasis 54.49 10.22 297 420558 22915 64054962
Depressed level of consciousness 54.37 10.22 310 420545 81126 63996751
Hypogammaglobulinaemia 54.07 10.22 169 420686 10130 64067747
Panic attack 54.04 10.22 35 420820 20918 64056959
Crying 53.98 10.22 32 420823 20058 64057819
Right ventricular failure 53.85 10.22 37 420818 21434 64056443
Pleural effusion 53.49 10.22 1140 419715 125419 63952458
Device malfunction 53.45 10.22 24 420831 17609 64060268
Hypocalcaemia 53.43 10.22 460 420395 41293 64036584
Muscle spasticity 53.24 10.22 21 420834 16648 64061229
Angioedema 53.14 10.22 215 420640 61606 64016271
Fear 52.98 10.22 33 420822 20138 64057739
Adrenal insufficiency 52.97 10.22 288 420567 22199 64055678
Nocardiosis 52.64 10.22 104 420751 4663 64073214
Staphylococcal bacteraemia 52.60 10.22 168 420687 10187 64067690
Pneumonia fungal 52.58 10.22 152 420703 8725 64069152
Primary amyloidosis 52.17 10.22 22 420833 98 64077779
Dysgeusia 51.92 10.22 502 420353 46545 64031332
Neutropenic colitis 51.87 10.22 101 420754 4480 64073397
Product complaint 51.79 10.22 8 420847 11946 64065931
Visceral leishmaniasis 51.69 10.22 46 420809 921 64076956
Type 2 diabetes mellitus 51.66 10.22 89 420766 33931 64043946
Taste disorder 51.57 10.22 157 420698 9276 64068601
Microsporidia infection 51.50 10.22 42 420813 743 64077134
Bronchospasm 51.29 10.22 278 420577 21404 64056473
Pseudomonas infection 51.23 10.22 242 420613 17641 64060236
Eczema 50.60 10.22 72 420783 29648 64048229
Injection site rash 50 10.22 20 420835 15722 64062155
Blood cholesterol increased 49.70 10.22 164 420691 49902 64027975
Peripheral sensorimotor neuropathy 49.36 10.22 72 420783 2513 64075364
Nephrolithiasis 49.17 10.22 135 420720 43548 64034329
Underdose 48.68 10.22 58 420797 25771 64052106
B precursor type acute leukaemia 48.54 10.22 28 420827 271 64077606
Neutropenic infection 48.54 10.22 62 420793 1903 64075974
Eosinophilia 48.04 10.22 111 420744 37965 64039912
Stomatitis 47.85 10.22 992 419863 108613 63969264
Pneumonia pneumococcal 47.72 10.22 80 420775 3154 64074723
Escherichia sepsis 47.68 10.22 128 420727 7037 64070840
Glioblastoma 47.46 10.22 53 420802 1408 64076469
Hypertransaminasaemia 47.38 10.22 128 420727 7063 64070814
Product storage error 47.35 10.22 14 420841 13304 64064573
Injection site urticaria 47.28 10.22 8 420847 11173 64066704
Impaired work ability 47.26 10.22 20 420835 15199 64062678
Blood pressure diastolic abnormal 47.25 10.22 10 420845 11907 64065970
Respiratory depression 47.07 10.22 50 420805 23393 64054484
Refractory anaemia with an excess of blasts 46.73 10.22 41 420814 805 64077072
Disseminated intravascular coagulation 46.56 10.22 366 420489 31982 64045895
Performance status decreased 46.46 10.22 106 420749 5258 64072619
Injection site induration 46.39 10.22 3 420852 8929 64068948
Renal failure 46.20 10.22 1531 419324 180157 63897720
Road traffic accident 46.17 10.22 81 420774 30664 64047213
Extrapyramidal disorder 46.04 10.22 36 420819 19516 64058361
Anhedonia 45.90 10.22 16 420839 13690 64064187
Rectal adenocarcinoma 45.84 10.22 50 420805 1293 64076584
Tendonitis 45.70 10.22 39 420816 20243 64057634
Gastrointestinal disorder 45.68 10.22 370 420485 89339 63988538
Respiratory syncytial virus infection 45.53 10.22 127 420728 7141 64070736
Hiatus hernia 45.43 10.22 38 420817 19919 64057958
Bone erosion 45.43 10.22 10 420845 11585 64066292
Enthesopathy 45.23 10.22 5 420850 9633 64068244
Rhinocerebral mucormycosis 44.97 10.22 32 420823 457 64077420
Gastrointestinal perforation 44.58 10.22 105 420750 5319 64072558
Product administration error 44.13 10.22 70 420785 27573 64050304
Meningitis cryptococcal 43.82 10.22 74 420781 2935 64074942
Iron deficiency anaemia 43.60 10.22 47 420808 21842 64056035
Brain stem glioma 43.58 10.22 21 420834 135 64077742
Dyskinesia 43.39 10.22 123 420732 39265 64038612
Emotional distress 43.13 10.22 108 420747 35930 64041947
Ocular hypertension 43.13 10.22 47 420808 1214 64076663
Keratitis fungal 43.07 10.22 22 420833 163 64077714
JC virus infection 43.00 10.22 78 420777 3277 64074600
Carpal tunnel syndrome 42.82 10.22 25 420830 15803 64062074
Tardive dyskinesia 42.48 10.22 5 420850 9173 64068704
Venous thrombosis 42.47 10.22 114 420741 6267 64071610
Prescribed overdose 42.37 10.22 42 420813 20289 64057588
Transplant rejection 42.31 10.22 31 420824 17370 64060507
Device related infection 42.16 10.22 343 420512 30283 64047594
Multiple sclerosis 41.98 10.22 37 420818 18904 64058973
Infection 41.79 10.22 1537 419318 183343 63894534
Staphylococcal sepsis 41.77 10.22 181 420674 12718 64065159
Second primary malignancy 41.40 10.22 175 420680 12162 64065715
Urticaria 41.25 10.22 694 420161 146623 63931254
Therapy non-responder 41.05 10.22 631 420224 65268 64012609
Foot fracture 40.81 10.22 35 420820 18122 64059755
Acute respiratory distress syndrome 40.80 10.22 411 420444 38524 64039353
Substance abuse 40.76 10.22 6 420849 9286 64068591
Poor venous access 40.73 10.22 15 420840 12402 64065475
Pneumonia bacterial 40.58 10.22 200 420655 14835 64063042
Non-small cell lung cancer 40.56 10.22 95 420760 4795 64073082
Hyperbilirubinaemia 40.51 10.22 257 420598 20948 64056929
Hallucination, visual 40.30 10.22 75 420780 27759 64050118
Pulmonary mucormycosis 40.21 10.22 37 420818 775 64077102
Lupus-like syndrome 40.17 10.22 5 420850 8786 64069091
Intentional product use issue 40.02 10.22 413 420442 94951 63982926
Nightmare 39.71 10.22 47 420808 20946 64056931
Haematoma 39.65 10.22 161 420694 46089 64031788
Sleep disorder due to a general medical condition 39.34 10.22 4 420851 8230 64069647
Metapneumovirus infection 39.12 10.22 48 420807 1413 64076464
Frequent bowel movements 39.09 10.22 37 420818 18268 64059609
Withdrawal syndrome 38.93 10.22 58 420797 23434 64054443
Obstructive airways disorder 38.66 10.22 57 420798 23128 64054749
Loss of consciousness 38.65 10.22 708 420147 147657 63930220
Peripheral swelling 38.53 10.22 1054 419801 208099 63869778
Blood culture positive 38.47 10.22 126 420729 7742 64070135
Human bocavirus infection 38.41 10.22 31 420824 540 64077337
Torsade de pointes 38.38 10.22 34 420821 17329 64060548
Drug level increased 38.25 10.22 106 420749 34090 64043787
Depressed mood 38.23 10.22 138 420717 40874 64037003
Blood pressure systolic abnormal 38.10 10.22 9 420846 9933 64067944
Paraplegia 38.09 10.22 88 420767 4402 64073475
Disseminated cryptococcosis 38.01 10.22 49 420806 1518 64076359
Infection reactivation 37.98 10.22 56 420799 1974 64075903
Coombs indirect test positive 37.83 10.22 15 420840 55 64077822
Disability 37.79 10.22 16 420839 12156 64065721
Exposure during pregnancy 37.46 10.22 325 420530 77350 64000527
Meningitis pneumococcal 37.40 10.22 26 420829 357 64077520
Visual acuity reduced 37.38 10.22 304 420551 26837 64051040
Hyperaemia 37.32 10.22 65 420790 2644 64075233
Respiratory distress 37.31 10.22 513 420342 51818 64026059
Coeliac disease 37.03 10.22 3 420852 7409 64070468
Enterocolitis 36.92 10.22 166 420689 11852 64066025
Pneumonia cytomegaloviral 36.76 10.22 85 420770 4254 64073623
Bursitis 36.63 10.22 52 420803 21433 64056444
Neck pain 36.51 10.22 243 420612 61290 64016587
Cushingoid 36.50 10.22 121 420734 7482 64070395
Hypothyroidism 36.49 10.22 138 420717 40319 64037558
Hallucination, auditory 36.45 10.22 34 420821 16905 64060972
Haemoglobin decreased 36.28 10.22 1588 419267 193475 63884402
Leukoencephalopathy 36.27 10.22 114 420741 6853 64071024
Disseminated aspergillosis 36.15 10.22 32 420823 636 64077241
Radiation skin injury 36.11 10.22 44 420811 1286 64076591
Differentiation syndrome 36.06 10.22 55 420800 1999 64075878
Akathisia 35.95 10.22 15 420840 11495 64066382
Neoplasm recurrence 35.90 10.22 77 420778 3662 64074215
Miosis 35.82 10.22 21 420834 13245 64064632
Mycobacterium chelonae infection 35.80 10.22 56 420799 2081 64075796
Joint injury 35.79 10.22 59 420796 22888 64054989
Hypercholesterolaemia 35.33 10.22 29 420826 15344 64062533
Recall phenomenon 35.29 10.22 38 420817 968 64076909
Fusarium infection 34.87 10.22 47 420808 1522 64076355
Ulcerative keratitis 34.72 10.22 68 420787 3029 64074848
Pneumonia viral 34.49 10.22 121 420734 7701 64070176
Pneumatosis intestinalis 34.38 10.22 93 420762 5136 64072741
Drug level decreased 34.33 10.22 16 420839 11487 64066390
Chest pain 34.28 10.22 1227 419628 234753 63843124
Burning sensation 34.27 10.22 187 420668 49477 64028400
Nervous system disorder 34.26 10.22 263 420592 22815 64055062
Progressive multifocal leukoencephalopathy 34.23 10.22 220 420635 18012 64059865
Haematochezia 34.14 10.22 273 420582 66100 64011777
Exostosis 34.00 10.22 16 420839 11422 64066455
Spinal compression fracture 33.98 10.22 188 420667 14587 64063290
Mantle cell lymphoma recurrent 33.80 10.22 27 420828 463 64077414
Stem cell transplant 33.78 10.22 72 420783 3409 64074468
Basal cell carcinoma 33.51 10.22 328 420527 30510 64047367
Coronary artery occlusion 33.44 10.22 25 420830 13866 64064011
Cholecystectomy 33.41 10.22 6 420849 8026 64069851
Device breakage 33.40 10.22 8 420847 8747 64069130
Arachnoiditis 33.35 10.22 31 420824 658 64077219
Necrotising fasciitis 33.30 10.22 93 420762 5233 64072644
Muscle rigidity 33.18 10.22 39 420816 17434 64060443
Minimal residual disease 33.17 10.22 25 420830 392 64077485
Amnesia 33.16 10.22 182 420673 48087 64029790
Thrombotic microangiopathy 33.16 10.22 204 420651 16451 64061426
Ileus 33.13 10.22 260 420595 22706 64055171
Pseudomonas test positive 32.93 10.22 46 420809 1542 64076335
Pulmonary hypertension 32.84 10.22 157 420698 42982 64034895
Streptococcal bacteraemia 32.77 10.22 66 420789 3001 64074876
Varicella zoster virus infection 32.76 10.22 76 420779 3812 64074065
Cholelithiasis 32.70 10.22 169 420686 45337 64032540
Central nervous system leukaemia 32.68 10.22 24 420831 361 64077516
Gastrointestinal haemorrhage 32.42 10.22 638 420217 131674 63946203
Cardiotoxicity 32.38 10.22 143 420712 10131 64067746
Brain abscess 32.28 10.22 79 420776 4102 64073775
Atrial flutter 32.28 10.22 227 420628 19153 64058724
Anger 32.25 10.22 33 420822 15708 64062169
Angina unstable 32.17 10.22 32 420823 15435 64062442
Cardio-respiratory arrest 32.15 10.22 450 420405 97943 63979934
Gastric perforation 32.06 10.22 71 420784 3452 64074425
Lip swelling 32.02 10.22 104 420751 31803 64046074
Memory impairment 32.01 10.22 381 420474 85301 63992576
Blood immunoglobulin G increased 31.90 10.22 49 420806 1792 64076085
Disease recurrence 31.76 10.22 330 420525 31180 64046697
Pemphigoid 31.75 10.22 23 420832 12963 64064914
Protein total increased 31.74 10.22 69 420786 3312 64074565
Sedation complication 31.53 10.22 14 420841 10340 64067537
Cryptococcosis 31.51 10.22 61 420794 2694 64075183
Abnormal behaviour 31.43 10.22 113 420742 33509 64044368
Malignant transformation 31.39 10.22 38 420817 1103 64076774
Aplastic anaemia 31.26 10.22 176 420679 13744 64064133
Immunosuppressant drug level increased 31.13 10.22 5 420850 7254 64070623
Weight decreased 31.12 10.22 1535 419320 284204 63793673
Encephalitis 30.97 10.22 163 420692 12408 64065469
Erythema 30.91 10.22 1505 419350 185565 63892312
Back pain 30.82 10.22 1959 418896 248212 63829665
Listeriosis 30.77 10.22 50 420805 1920 64075957
Device leakage 30.67 10.22 8 420847 8258 64069619
Cytomegalovirus viraemia 30.63 10.22 146 420709 10682 64067195
Arteriosclerosis 30.62 10.22 35 420820 15842 64062035
Electrocardiogram QRS complex prolonged 30.60 10.22 11 420844 9233 64068644
Enterococcal bacteraemia 30.55 10.22 57 420798 2448 64075429
Panniculitis 30.37 10.22 10 420845 8869 64069008
Immune effector cell-associated neurotoxicity syndrome 30.35 10.22 58 420797 2537 64075340
Joint effusion 30.24 10.22 26 420829 13447 64064430
Necrotising retinitis 30.22 10.22 36 420819 1027 64076850
Venous thrombosis limb 30.16 10.22 73 420782 3764 64074113
Chronic obstructive pulmonary disease 30.09 10.22 307 420548 70741 64007136
Polyp 29.99 10.22 4 420851 6669 64071208
Ecthyma 29.76 10.22 28 420827 604 64077273
Immunosuppression 29.75 10.22 144 420711 10602 64067275
Sputum discoloured 29.67 10.22 44 420811 17812 64060065
Cellulitis orbital 29.63 10.22 29 420826 658 64077219
Fungal oesophagitis 29.48 10.22 31 420824 768 64077109
Abdominal pain upper 29.46 10.22 893 419962 174137 63903740
Meningitis bacterial 29.43 10.22 54 420801 2289 64075588
Exposure to toxic agent 29.40 10.22 3 420852 6156 64071721
Crossmatch incompatible 29.39 10.22 11 420844 33 64077844
Guillain-Barre syndrome 29.37 10.22 113 420742 7522 64070355
Lung infiltration 29.32 10.22 235 420620 20654 64057223
Hypothermia 29.19 10.22 53 420802 19803 64058074
Cell-mediated immune deficiency 28.93 10.22 14 420841 91 64077786
Cardiac murmur 28.90 10.22 20 420835 11543 64066334
Sexual dysfunction 28.80 10.22 4 420851 6467 64071410
Coombs positive haemolytic anaemia 28.78 10.22 32 420823 846 64077031
Metastatic malignant melanoma 28.74 10.22 56 420799 2485 64075392
Kidney transplant rejection 28.74 10.22 13 420842 9498 64068379
Fungaemia 28.68 10.22 71 420784 3714 64074163
Laryngospasm 28.65 10.22 67 420788 3378 64074499
Vascular pain 28.63 10.22 31 420824 795 64077082
Faeces discoloured 28.59 10.22 80 420775 25649 64052228
Anaphylactic reaction 28.51 10.22 617 420238 68047 64009830
Negative pressure pulmonary oedema 28.44 10.22 18 420837 209 64077668
Light chain analysis abnormal 28.40 10.22 15 420840 120 64077757
Delusion 28.39 10.22 46 420809 17968 64059909
Grip strength decreased 28.36 10.22 21 420834 11703 64066174
Angina pectoris 28.29 10.22 175 420680 44906 64032971
Bradyphrenia 28.20 10.22 13 420842 9393 64068484
Hyperlipidaemia 28.17 10.22 68 420787 22908 64054969
Computerised tomogram thorax abnormal 28.12 10.22 48 420807 1921 64075956
Steroid diabetes 28.05 10.22 57 420798 2609 64075268
Gastric disorder 28.05 10.22 97 420758 29100 64048777
Pulmonary sepsis 28.01 10.22 62 420793 3013 64074864
Bone density decreased 27.96 10.22 15 420840 9937 64067940
Chalazion 27.92 10.22 23 420832 413 64077464
Alanine aminotransferase increased 27.67 10.22 1140 419715 137891 63939986
Enterobacter infection 27.65 10.22 69 420786 3627 64074250
Ovarian cyst 27.61 10.22 19 420836 10999 64066878
Disturbance in attention 27.60 10.22 156 420699 40918 64036959
Antinuclear antibody positive 27.50 10.22 4 420851 6246 64071631
Acute interstitial pneumonitis 27.40 10.22 34 420821 1013 64076864
Coronary artery bypass 27.33 10.22 3 420852 5812 64072065
Drug abuser 27.29 10.22 3 420852 5805 64072072
Escherichia infection 27.24 10.22 181 420674 14987 64062890
Sternal fracture 27.24 10.22 51 420804 2196 64075681
Therapeutic response unexpected 27.19 10.22 43 420812 16958 64060919
Body temperature decreased 27.08 10.22 83 420772 25845 64052032
Product dispensing error 27.06 10.22 21 420834 11429 64066448
Klebsiella bacteraemia 26.99 10.22 52 420803 2288 64075589
Tuberculoma of central nervous system 26.96 10.22 25 420830 529 64077348
Alopecia areata 26.94 10.22 41 420814 1487 64076390
H1N1 influenza 26.93 10.22 51 420804 2215 64075662
Embolism venous 26.80 10.22 66 420789 3441 64074436
B-cell lymphoma recurrent 26.71 10.22 30 420825 802 64077075
Meningoencephalitis herpetic 26.57 10.22 44 420811 1717 64076160
Blood loss anaemia 26.39 10.22 31 420824 13861 64064016
Peritonitis bacterial 26.34 10.22 13 420842 9030 64068847
Corneal opacity 26.31 10.22 31 420824 874 64077003
Enterocolitis infectious 26.30 10.22 53 420802 2411 64075466
Cancer pain 26.29 10.22 74 420781 4183 64073694
Viral haemorrhagic cystitis 26.23 10.22 42 420813 1593 64076284
Capillary leak syndrome 26.21 10.22 63 420792 3234 64074643
Paraproteinaemia 25.96 10.22 21 420834 367 64077510
Thymus hypoplasia 25.84 10.22 24 420831 509 64077368
Oroantral fistula 25.82 10.22 21 420834 370 64077507
Perineal necrosis 25.80 10.22 14 420841 119 64077758
Phaeochromocytoma crisis 25.75 10.22 19 420836 288 64077589
Dry mouth 25.61 10.22 261 420594 60157 64017720
Blood lactate dehydrogenase increased 25.54 10.22 329 420526 32749 64045128
Chills 25.40 10.22 1117 419738 136147 63941730
Enteritis 25.36 10.22 150 420705 11927 64065950
Blood immunoglobulin A increased 25.23 10.22 24 420831 525 64077352
Enterococcal infection 25.23 10.22 166 420689 13700 64064177
Blood potassium decreased 25.22 10.22 387 420468 40012 64037865
Pneumonia parainfluenzae viral 25.12 10.22 18 420837 260 64077617
Ear infection 25.11 10.22 74 420781 23330 64054547
Heavy menstrual bleeding 25.10 10.22 25 420830 12052 64065825
B-cell type acute leukaemia 24.99 10.22 22 420833 434 64077443
Melaena 24.95 10.22 226 420629 53322 64024555
Food allergy 24.89 10.22 10 420845 7841 64070036
Blood glucose decreased 24.89 10.22 73 420782 23050 64054827
Lymphocyte count decreased 24.69 10.22 388 420467 40311 64037566
Hypopyon 24.68 10.22 32 420823 997 64076880
Lentigo maligna 24.66 10.22 22 420833 442 64077435
Spinal operation 24.62 10.22 5 420850 6128 64071749
Device use error 24.52 10.22 6 420849 6465 64071412
Swollen tongue 24.45 10.22 131 420724 34823 64043054
Clostridium bacteraemia 24.44 10.22 18 420837 272 64077605
Superior sagittal sinus thrombosis 24.43 10.22 31 420824 945 64076932
Leukaemia recurrent 24.42 10.22 53 420802 2541 64075336
Heart rate increased 24.41 10.22 475 420380 98200 63979677
Drug tolerance 24.35 10.22 5 420850 6080 64071797
Failure to thrive 24.34 10.22 133 420722 10271 64067606
Musculoskeletal discomfort 24.33 10.22 43 420812 16234 64061643
Hypophosphataemia 24.27 10.22 172 420683 14548 64063329
Eosinophil count increased 24.21 10.22 34 420821 14078 64063799
Klebsiella infection 24.17 10.22 159 420696 13122 64064755
Salivary hypersecretion 24.13 10.22 26 420829 12087 64065790
Unintentional medical device removal 24.08 10.22 7 420848 6727 64071150
Atypical haemolytic uraemic syndrome 24.03 10.22 26 420829 666 64077211
Autoimmune lymphoproliferative syndrome 24.00 10.22 15 420840 170 64077707
Urosepsis 24.00 10.22 235 420620 21859 64056018
Gynaecomastia 23.95 10.22 5 420850 6011 64071866
Transplant dysfunction 23.94 10.22 7 420848 6701 64071176
Mitochondrial DNA mutation 23.94 10.22 17 420838 242 64077635
Haematemesis 23.85 10.22 194 420661 46805 64031072
Cardiac failure congestive 23.78 10.22 659 420196 129921 63947956
Human herpesvirus 8 infection 23.63 10.22 32 420823 1041 64076836
Device adhesion issue 23.57 10.22 3 420852 5183 64072694
Human chorionic gonadotropin increased 23.55 10.22 29 420826 857 64077020
Productive cough 23.48 10.22 336 420519 72867 64005010
Familial periodic paralysis 23.47 10.22 14 420841 145 64077732
Lipogranuloma 23.46 10.22 7 420848 7 64077870
Metabolic acidosis 23.36 10.22 324 420531 70634 64007243
Acne 23.32 10.22 75 420780 23006 64054871
Skin striae 23.30 10.22 37 420818 1393 64076484
Movement disorder 23.28 10.22 70 420785 21930 64055947
Feeling hot 23.21 10.22 423 420432 45240 64032637
Meningitis listeria 23.20 10.22 27 420828 751 64077126
Blood immunoglobulin M increased 23.17 10.22 21 420834 431 64077446
Erectile dysfunction 23.11 10.22 29 420826 12598 64065279
Illness 23.08 10.22 70 420785 21868 64056009
Large intestine polyp 23.03 10.22 22 420833 10815 64067062
Forced expiratory volume decreased 23.03 10.22 8 420847 6859 64071018
Cytomegalovirus colitis 23.01 10.22 67 420788 3861 64074016
Taeniasis 22.96 10.22 10 420845 49 64077828
Adenocarcinoma gastric 22.93 10.22 39 420816 1556 64076321
Ischaemic cardiomyopathy 22.87 10.22 8 420847 6830 64071047
Intraocular pressure decreased 22.76 10.22 14 420841 154 64077723
Colitis microscopic 22.71 10.22 10 420845 7422 64070455
General physical health deterioration 22.70 10.22 1587 419268 202838 63875039
Liver function test abnormal 22.62 10.22 263 420592 59138 64018739
Frustration tolerance decreased 22.59 10.22 6 420849 6119 64071758
Post procedural complication 22.56 10.22 68 420787 21285 64056592
Blood potassium increased 22.54 10.22 90 420765 25890 64051987
Disseminated strongyloidiasis 22.52 10.22 12 420843 98 64077779
Superficial spreading melanoma stage unspecified 22.48 10.22 17 420838 268 64077609
Corneal infiltrates 22.48 10.22 17 420838 268 64077609
Haemorrhage 22.47 10.22 373 420482 78978 63998899
Blood thyroid stimulating hormone increased 22.30 10.22 11 420844 7643 64070234
Hypoalbuminaemia 22.23 10.22 194 420661 17480 64060397
Post procedural infection 22.18 10.22 18 420837 9579 64068298
Sickle cell anaemia with crisis 22.14 10.22 4 420851 5328 64072549
Vitreous loss 22.13 10.22 7 420848 10 64077867
Intervertebral disc degeneration 22.12 10.22 32 420823 13088 64064789
Jugular vein thrombosis 22.11 10.22 65 420790 3766 64074111
Pseudomonal bacteraemia 22.10 10.22 47 420808 2222 64075655
Sinus congestion 22.00 10.22 42 420813 15397 64062480
Cerebral venous thrombosis 21.99 10.22 49 420806 2392 64075485
Blood stem cell transplant failure 21.99 10.22 22 420833 513 64077364
Chorioretinopathy 21.97 10.22 46 420809 2151 64075726
Gastric ulcer 21.88 10.22 112 420743 30122 64047755
Cataract subcapsular 21.88 10.22 28 420827 861 64077016
Cardiomegaly 21.87 10.22 80 420775 23604 64054273
Gastrointestinal fungal infection 21.83 10.22 19 420836 369 64077508
Choroidal detachment 21.75 10.22 22 420833 520 64077357
Lymphoid tissue hypoplasia 21.69 10.22 21 420834 470 64077407
Body dysmorphic disorder 21.66 10.22 16 420839 243 64077634
Antithrombin III decreased 21.65 10.22 20 420835 421 64077456
Renal amyloidosis 21.60 10.22 13 420842 137 64077740
Prescribed underdose 21.55 10.22 54 420801 17961 64059916
Peritonitis 21.53 10.22 254 420601 24769 64053108
Hemiparesis 21.50 10.22 293 420562 29534 64048343
Diverticulum 21.47 10.22 33 420822 13165 64064712
Dystonia 21.45 10.22 58 420797 18807 64059070
Cataract 21.40 10.22 461 420394 50801 64027076
Congenital herpes simplex infection 21.36 10.22 7 420848 12 64077865
Pneumonia escherichia 21.33 10.22 26 420829 760 64077117
Limb injury 21.31 10.22 80 420775 23425 64054452
Bone marrow infiltration 21.30 10.22 21 420834 481 64077396
Pneumoretroperitoneum 21.26 10.22 11 420844 84 64077793
Propofol infusion syndrome 21.24 10.22 38 420817 1579 64076298
Hydrocephalus 21.22 10.22 102 420753 7489 64070388
Abdominal sepsis 21.21 10.22 41 420814 1809 64076068
Stridor 21.15 10.22 75 420780 4799 64073078
Schizophrenia 21.13 10.22 25 420830 11143 64066734
Chronic kidney disease 21.07 10.22 259 420596 57660 64020217
Product packaging confusion 20.97 10.22 15 420840 216 64077661
Rotator cuff syndrome 20.94 10.22 29 420826 12078 64065799
Blood stem cell harvest failure 20.94 10.22 11 420844 87 64077790
Clostridium difficile infection 20.90 10.22 342 420513 35821 64042056
Pulmonary fibrosis 20.89 10.22 112 420743 29766 64048111
Mental disorder 20.86 10.22 95 420760 26350 64051527
Breast cancer female 20.82 10.22 4 420851 5099 64072778
Neurological decompensation 20.76 10.22 70 420785 4366 64073511
Heart rate irregular 20.73 10.22 100 420755 27313 64050564
Mesenteric abscess 20.73 10.22 12 420843 117 64077760
Hysterectomy 20.72 10.22 4 420851 5081 64072796
Restless legs syndrome 20.71 10.22 51 420804 17065 64060812
Colorectal adenocarcinoma 20.69 10.22 17 420838 304 64077573
Spinal stenosis 20.65 10.22 37 420818 13894 64063983
Salmonella sepsis 20.62 10.22 18 420837 351 64077526
Neutrophil count abnormal 20.56 10.22 53 420802 2843 64075034
Cellulitis 20.51 10.22 776 420079 92881 63984996
Ventricular tachycardia 20.48 10.22 135 420720 34130 64043747
Large intestinal ulcer perforation 20.41 10.22 10 420845 67 64077810
Respirovirus test positive 20.39 10.22 12 420843 121 64077756
Scar 20.39 10.22 35 420820 13363 64064514
Blood pressure inadequately controlled 20.38 10.22 5 420850 5379 64072498
Spinal fracture 20.38 10.22 169 420686 15005 64062872
Subclavian vein thrombosis 20.35 10.22 46 420809 2268 64075609
Device failure 20.20 10.22 6 420849 5686 64072191
Steroid withdrawal syndrome 20.13 10.22 23 420832 627 64077250
Cauda equina syndrome 20.02 10.22 30 420825 1073 64076804
Mitral valve incompetence 19.99 10.22 92 420763 25446 64052431
Eastern Cooperative Oncology Group performance status worsened 19.94 10.22 32 420823 1216 64076661
Injection site discolouration 19.85 10.22 10 420845 6865 64071012
Gastrointestinal toxicity 19.85 10.22 78 420777 5244 64072633
Cellulitis enterococcal 19.84 10.22 8 420847 31 64077846
Aeromonas infection 19.79 10.22 17 420838 324 64077553
Abnormal dreams 19.79 10.22 23 420832 10333 64067544
Campylobacter gastroenteritis 19.76 10.22 30 420825 1086 64076791
Procedural pain 19.73 10.22 45 420810 15463 64062414
Encephalitis brain stem 19.73 10.22 14 420841 199 64077678
VIth nerve paresis 19.66 10.22 12 420843 130 64077747
Adenocarcinoma pancreas 19.65 10.22 40 420815 1833 64076044
Compression fracture 19.62 10.22 82 420773 5670 64072207
Light chain disease 19.61 10.22 14 420841 201 64077676
Mucosal infection 19.60 10.22 19 420836 426 64077451
Bone debridement 19.60 10.22 19 420836 426 64077451
Cholecystitis chronic 19.56 10.22 19 420836 9268 64068609
Alpha haemolytic streptococcal infection 19.49 10.22 38 420817 1687 64076190
Vitreous haemorrhage 19.42 10.22 54 420801 3031 64074846
Alcohol abuse 19.39 10.22 4 420851 4848 64073029
Retinal detachment 19.36 10.22 103 420752 7873 64070004
Head injury 19.33 10.22 130 420725 32712 64045165
Pseudocellulitis 19.32 10.22 9 420846 53 64077824
Finger deformity 19.28 10.22 5 420850 5181 64072696
Atypical pneumonia 19.27 10.22 77 420778 5217 64072660
Vitamin D deficiency 19.24 10.22 29 420826 11663 64066214
Ureteric compression 19.23 10.22 13 420842 170 64077707
Morganella infection 19.18 10.22 28 420827 978 64076899
Corneal perforation 19.18 10.22 23 420832 661 64077216
Ulcer 19.10 10.22 81 420774 22909 64054968
Sense of oppression 19.00 10.22 34 420821 1413 64076464
Arteriosclerosis coronary artery 19.00 10.22 46 420809 15483 64062394
Fluid retention 18.97 10.22 274 420581 59332 64018545
Rib fracture 18.94 10.22 240 420615 23798 64054079
Testicular germ cell cancer metastatic 18.92 10.22 9 420846 56 64077821
Keratitis bacterial 18.91 10.22 12 420843 140 64077737
Platelet count abnormal 18.47 10.22 64 420791 4048 64073829
Alanine aminotransferase abnormal 18.46 10.22 11 420844 6877 64071000
Deformity 18.42 10.22 9 420846 6288 64071589
Pseudomyopia 18.41 10.22 9 420846 60 64077817
Photosensitivity reaction 18.40 10.22 59 420796 18114 64059763
Escherichia test positive 18.33 10.22 50 420805 2775 64075102
Impaired driving ability 18.26 10.22 4 420851 4650 64073227
Salmonellosis 18.19 10.22 32 420823 1312 64076565
Birdshot chorioretinopathy 18.16 10.22 9 420846 62 64077815
Amenorrhoea 18.16 10.22 10 420845 6529 64071348
Pain in jaw 18.13 10.22 174 420681 40581 64037296
Drug resistance 18.13 10.22 326 420529 34776 64043101
Corneal thinning 18.08 10.22 12 420843 152 64077725
Malignant melanoma in situ 18.07 10.22 38 420817 1782 64076095
Metastases to bone marrow 17.97 10.22 22 420833 646 64077231
Alcohol use 17.97 10.22 4 420851 4598 64073279
Rash 17.90 10.22 3324 417531 455225 63622652
Microangiopathic haemolytic anaemia 17.88 10.22 32 420823 1330 64076547
Tonsillar disorder 17.85 10.22 27 420828 974 64076903
Meningitis 17.85 10.22 104 420751 8225 64069652
Epstein-Barr virus associated lymphoma 17.84 10.22 26 420829 907 64076970
Glioblastoma multiforme 17.82 10.22 29 420826 1115 64076762
Social avoidant behaviour 17.71 10.22 4 420851 4553 64073324
Tumour perforation 17.71 10.22 16 420839 327 64077550
Oxygen saturation 17.68 10.22 14 420841 237 64077640
Diffuse large B-cell lymphoma 17.63 10.22 122 420733 10239 64067638
Blood fibrinogen decreased 17.56 10.22 33 420822 1425 64076452
VIth nerve paralysis 17.43 10.22 33 420822 1433 64076444
Tricuspid valve incompetence 17.36 10.22 55 420800 16948 64060929
Scoliosis 17.33 10.22 9 420846 6073 64071804
Lung transplant 17.24 10.22 3 420852 4105 64073772
Epstein Barr virus positive mucocutaneous ulcer 17.23 10.22 22 420833 675 64077202
Abscess bacterial 17.22 10.22 23 420832 738 64077139
Cerebral haematoma 17.21 10.22 13 420842 7172 64070705
Long QT syndrome 17.21 10.22 6 420849 5133 64072744
Dyspnoea 17.17 10.22 5094 415761 713580 63364297
Drug level above therapeutic 17.16 10.22 12 420843 6889 64070988
Anal inflammation 17.15 10.22 18 420837 445 64077432
Menstruation irregular 17.02 10.22 4 420851 4431 64073446
Paraesthesia 17.02 10.22 1056 419799 133466 63944411
Dyspnoea exertional 17.02 10.22 359 420496 73371 64004506
Pollakiuria 17.00 10.22 128 420727 31402 64046475
Pulmonary congestion 16.98 10.22 89 420766 23791 64054086
Amoebiasis 16.98 10.22 10 420845 101 64077776
Feeling cold 16.97 10.22 88 420767 23590 64054287
Gastritis 16.89 10.22 187 420668 42431 64035446
Bradykinesia 16.86 10.22 11 420844 6549 64071328
Pharyngitis streptococcal 16.83 10.22 19 420836 8649 64069228
Ejection fraction decreased 16.78 10.22 272 420583 28435 64049442
Pneumonia respiratory syncytial viral 16.75 10.22 32 420823 1399 64076478
Phrenic nerve paralysis 16.67 10.22 13 420842 215 64077662
Intentional dose omission 16.66 10.22 8 420847 5644 64072233
Periorbital infection 16.64 10.22 9 420846 76 64077801
Cardiac pacemaker insertion 16.59 10.22 6 420849 5017 64072860
Vein discolouration 16.59 10.22 15 420840 307 64077570
Lacrimation increased 16.57 10.22 188 420667 18158 64059719
Adverse drug reaction 16.53 10.22 401 420454 45063 64032814
Epistaxis 16.51 10.22 791 420064 97340 63980537
Asphyxia 16.46 10.22 23 420832 9543 64068334
Mucosal haemorrhage 16.46 10.22 42 420813 2239 64075638
Meniscus injury 16.45 10.22 9 420846 5898 64071979
Priapism 16.44 10.22 3 420852 3967 64073910
Therapy interrupted 16.39 10.22 71 420784 19965 64057912
Atrioventricular block first degree 16.37 10.22 28 420827 10706 64067171
Immunoglobulins increased 16.36 10.22 18 420837 470 64077407
Periodontitis 16.36 10.22 62 420793 4097 64073780
Pneumonia aspiration 16.33 10.22 280 420575 58991 64018886
Nodule 16.32 10.22 61 420794 17886 64059991
Pneumococcal sepsis 16.31 10.22 30 420825 1274 64076603
Skin candida 16.27 10.22 35 420820 1668 64076209
Incorrect product administration duration 16.26 10.22 24 420831 9734 64068143
Stent placement 16.24 10.22 8 420847 5563 64072314
Musculoskeletal disorder 16.20 10.22 61 420794 17845 64060032
Radiation necrosis 16.19 10.22 15 420840 317 64077560
Corneal abscess 16.16 10.22 8 420847 55 64077822
Ankle fracture 16.15 10.22 46 420809 14664 64063213
Pneumonia cryptococcal 16.13 10.22 29 420826 1210 64076667
Aortic arteriosclerosis 16.09 10.22 15 420840 7461 64070416
Nasal abscess 16.07 10.22 11 420844 147 64077730
Nail dystrophy 16.04 10.22 23 420832 790 64077087
5q minus syndrome 16.04 10.22 14 420841 273 64077604
Refractory anaemia with ringed sideroblasts 16.03 10.22 6 420849 18 64077859
Exercise tolerance decreased 15.98 10.22 16 420839 7694 64070183
Superior vena cava occlusion 15.95 10.22 10 420845 114 64077763
JC virus CSF test positive 15.95 10.22 11 420844 149 64077728
Initial insomnia 15.94 10.22 9 420846 5795 64072082
Injection site discomfort 15.94 10.22 4 420851 4237 64073640
Hereditary angioedema 15.90 10.22 3 420852 3873 64074004
Carotid intima-media thickness increased 15.88 10.22 9 420846 84 64077793
Malignant pleural effusion 15.86 10.22 49 420806 2918 64074959
Hyperamylasaemia 15.84 10.22 24 420831 867 64077010
Knee operation 15.82 10.22 5 420850 4552 64073325
Secretion discharge 15.81 10.22 34 420821 11930 64065947
Pneumonia mycoplasmal 15.79 10.22 30 420825 1306 64076571
Adverse event 15.76 10.22 173 420682 39316 64038561
Pneumonia klebsiella 15.74 10.22 60 420795 3977 64073900
Inflammatory bowel disease 15.72 10.22 5 420850 4533 64073344
Acute respiratory failure 15.69 10.22 432 420423 49502 64028375
Thyroid disorder 15.64 10.22 33 420822 11659 64066218
Respiratory rate increased 15.59 10.22 64 420791 18267 64059610
Catatonia 15.58 10.22 16 420839 7604 64070273
Renal cyst 15.57 10.22 37 420818 12533 64065344
Molluscum contagiosum 15.54 10.22 17 420838 441 64077436
Intermenstrual bleeding 15.49 10.22 7 420848 5118 64072759
Ileus paralytic 15.47 10.22 101 420754 8314 64069563
Osteomyelitis bacterial 15.45 10.22 17 420838 444 64077433
Expired product administered 15.44 10.22 10 420845 5977 64071900
Blood gases abnormal 15.42 10.22 25 420830 958 64076919
Blood calcium increased 15.38 10.22 102 420753 8440 64069437
Hepatic cytolysis 15.38 10.22 44 420811 14005 64063872
Blast cells present 15.34 10.22 23 420832 823 64077054
Body height decreased 15.34 10.22 93 420762 7461 64070416
Corneal disorder 15.33 10.22 38 420817 1989 64075888
Cryptococcal meningoencephalitis 15.31 10.22 12 420843 200 64077677
Catabolic state 15.27 10.22 9 420846 91 64077786
Hypertension 15.26 10.22 1470 419385 257791 63820086
Wrong patient received product 15.24 10.22 3 420852 3759 64074118
Uterine leiomyoma 15.22 10.22 8 420847 5361 64072516
Pre-existing condition improved 15.21 10.22 6 420849 4756 64073121
Cardiopulmonary failure 15.20 10.22 80 420775 6090 64071787
Amyotrophy 15.16 10.22 19 420836 572 64077305
Post procedural hypotension 15.15 10.22 8 420847 64 64077813
Intestinal atresia 15.15 10.22 8 420847 64 64077813
Dyslipidaemia 15.14 10.22 23 420832 9219 64068658
Plethoric face 15.13 10.22 6 420849 22 64077855
Polyarthritis 15.13 10.22 25 420830 9690 64068187
Posterior capsule rupture 15.10 10.22 5 420850 9 64077868
Haematoma muscle 15.05 10.22 35 420820 1758 64076119
Palmar erythema 15.04 10.22 34 420821 1676 64076201
Red blood cell count decreased 15.03 10.22 418 420437 47968 64029909
Breast cancer metastatic 15.03 10.22 89 420766 7080 64070797
Iris adhesions 15.02 10.22 18 420837 517 64077360
Central nervous system vasculitis 15.01 10.22 27 420828 1127 64076750
Hyperglycaemic hyperosmolar nonketotic syndrome 14.92 10.22 34 420821 1685 64076192
Emotional disorder 14.92 10.22 38 420817 12569 64065308
Prostate cancer 14.91 10.22 196 420659 19599 64058278
Erysipelas 14.91 10.22 106 420749 8975 64068902
Cystitis bacterial 14.88 10.22 16 420839 407 64077470
Sarcoidosis 14.88 10.22 11 420844 6135 64071742
Dental caries 14.85 10.22 30 420825 10770 64067107
Actinomycosis 14.84 10.22 24 420831 918 64076959
Human herpesvirus 6 infection 14.84 10.22 65 420790 4589 64073288
Snoring 14.79 10.22 6 420849 4676 64073201
Human herpesvirus 6 encephalitis 14.78 10.22 16 420839 410 64077467
Peritumoural oedema 14.77 10.22 5 420850 10 64077867
Plasma cell myeloma in remission 14.77 10.22 5 420850 10 64077867
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 14.77 10.22 5 420850 10 64077867
Hyperpyrexia 14.76 10.22 69 420786 5008 64072869
Pupillary deformity 14.73 10.22 6 420849 24 64077853
Metastases to retroperitoneum 14.71 10.22 15 420840 358 64077519
Granuloma 14.68 10.22 13 420842 6628 64071249
Spinal fusion surgery 14.61 10.22 3 420852 3648 64074229
Metastases to meninges 14.60 10.22 46 420809 2769 64075108
Tubulointerstitial nephritis 14.60 10.22 130 420725 30779 64047098
Cerebrovascular accident 14.59 10.22 741 420114 136842 63941035
Panophthalmitis 14.55 10.22 9 420846 100 64077777
Genital haemorrhage 14.55 10.22 9 420846 5513 64072364
SARS-CoV-2 test positive 14.46 10.22 80 420775 6206 64071671
Pneumococcal infection 14.44 10.22 22 420833 799 64077078
Oral pain 14.43 10.22 256 420599 27237 64050640
Trichosporon infection 14.43 10.22 23 420832 869 64077008
Retinal infiltrates 14.40 10.22 7 420848 46 64077831
Anaphylactoid shock 14.40 10.22 21 420834 733 64077144
Cholangiocarcinoma 14.40 10.22 37 420818 1981 64075896
Syringe issue 14.36 10.22 5 420850 4281 64073596
Impaired gastric emptying 14.33 10.22 22 420833 8782 64069095
Hypotony of eye 14.27 10.22 12 420843 222 64077655
Ankle brachial index decreased 14.27 10.22 8 420847 73 64077804
Appendiceal abscess 14.26 10.22 13 420842 269 64077608
Vertebral lesion 14.24 10.22 16 420839 428 64077449
Mucocutaneous ulceration 14.19 10.22 14 420841 321 64077556
Dental fistula 14.16 10.22 17 420838 489 64077388
Caesarean section 14.11 10.22 33 420822 11241 64066636
Antithrombin III deficiency 14.11 10.22 9 420846 106 64077771
Vasogenic cerebral oedema 14.08 10.22 24 420831 959 64076918
Pulse waveform abnormal 14.08 10.22 8 420847 75 64077802
Radiation oesophagitis 14.08 10.22 18 420837 553 64077324
Gastroenteritis norovirus 14.07 10.22 45 420810 2730 64075147
Babesiosis 14.06 10.22 13 420842 274 64077603
Administration site extravasation 14.06 10.22 25 420830 1034 64076843
Encephalitis enteroviral 14.04 10.22 10 420845 143 64077734
Norovirus test positive 14.04 10.22 16 420839 435 64077442
Pre-eclampsia 14.02 10.22 12 420843 6219 64071658
Psychotic disorder 13.99 10.22 151 420704 34427 64043450
Application site pruritus 13.97 10.22 3 420852 3536 64074341
Low density lipoprotein increased 13.94 10.22 18 420837 7722 64070155
Post-traumatic stress disorder 13.93 10.22 5 420850 4200 64073677
Blood prolactin increased 13.91 10.22 3 420852 3525 64074352
Computerised tomogram thorax 13.87 10.22 10 420845 146 64077731
Respiratory depth decreased 13.84 10.22 6 420849 29 64077848
Depressive symptom 13.82 10.22 6 420849 4490 64073387
Cholangitis infective 13.81 10.22 16 420839 443 64077434
Hepatitis E 13.80 10.22 41 420814 2390 64075487
Macular fibrosis 13.80 10.22 20 420835 694 64077183
Lung adenocarcinoma 13.79 10.22 84 420771 6749 64071128
Creatinine renal clearance decreased 13.79 10.22 48 420807 14373 64063504
Pneumomediastinum 13.79 10.22 46 420809 2854 64075023
Varicella 13.75 10.22 43 420812 2578 64075299
Toe amputation 13.75 10.22 3 420852 3497 64074380
Infusion related reaction 13.72 10.22 1249 419606 163218 63914659
Nephrogenic systemic fibrosis 13.68 10.22 11 420844 5881 64071996
Full blood count increased 13.67 10.22 16 420839 448 64077429
Cyst 13.66 10.22 37 420818 11990 64065887
Maternal exposure before pregnancy 13.65 10.22 3 420852 3480 64074397
Pneumonia staphylococcal 13.64 10.22 61 420794 4345 64073532
Acute erythroid leukaemia 13.62 10.22 12 420843 237 64077640
Squamous cell carcinoma of the hypopharynx 13.61 10.22 5 420850 14 64077863
Lung squamous cell carcinoma stage III 13.61 10.22 5 420850 14 64077863
Perineal infection 13.57 10.22 14 420841 339 64077538
Epstein-Barr virus infection reactivation 13.56 10.22 26 420829 1140 64076737
Pericardial haemorrhage 13.56 10.22 5 420850 4131 64073746
Chromaturia 13.56 10.22 89 420766 22522 64055355
Cardioactive drug level increased 13.55 10.22 3 420852 3462 64074415
Soft tissue infection 13.48 10.22 49 420806 3174 64074703
Abdominal pain 13.47 10.22 1809 419046 310566 63767311
Diabetic ketoacidosis 13.46 10.22 127 420728 29718 64048159
Herpes simplex 13.44 10.22 116 420739 10420 64067457
Blood calcium abnormal 13.42 10.22 27 420828 1227 64076650
Respiratory tract congestion 13.40 10.22 57 420798 16108 64061769
Amoebic colitis 13.40 10.22 8 420847 83 64077794
Ketoacidosis 13.38 10.22 15 420840 6848 64071029
Balamuthia infection 13.37 10.22 6 420849 32 64077845
Hypergeusia 13.36 10.22 5 420850 15 64077862
Hepatitis cholestatic 13.35 10.22 38 420817 12117 64065760
Viral myelitis 13.26 10.22 7 420848 56 64077821
Joint dislocation 13.23 10.22 35 420820 11430 64066447
Micturition urgency 13.23 10.22 30 420825 10329 64067548
Tuberculosis of central nervous system 13.21 10.22 15 420840 406 64077471
Procalcitonin increased 13.19 10.22 41 420814 2450 64075427
Oropharyngeal candidiasis 13.19 10.22 30 420825 1485 64076392
Apathy 13.18 10.22 34 420821 11198 64066679
Streptococcus test positive 13.16 10.22 35 420820 1913 64075964
Spinal cord injury 13.16 10.22 23 420832 938 64076939
Hypophagia 13.16 10.22 345 420510 39242 64038635
Transitional cell cancer of the renal pelvis and ureter 13.15 10.22 7 420848 57 64077820
Bacillus infection 13.13 10.22 20 420835 726 64077151
Sneezing 13.13 10.22 53 420802 15198 64062679
Janeway lesion 13.12 10.22 5 420850 16 64077861
Musculoskeletal chest pain 13.12 10.22 205 420650 21274 64056603
Irritability 13.11 10.22 165 420690 36581 64041296
White blood cell count increased 13.11 10.22 329 420526 65685 64012192
Target skin lesion 13.11 10.22 9 420846 121 64077756
Haematopoietic stem cell mobilisation 13.01 10.22 11 420844 205 64077672
Intracranial tumour haemorrhage 13.01 10.22 15 420840 413 64077464
Benign prostatic hyperplasia 13.00 10.22 25 420830 9140 64068737
Philadelphia chromosome positive 12.98 10.22 18 420837 599 64077278
Peripheral vascular disorder 12.96 10.22 17 420838 7244 64070633
Catheter management 12.93 10.22 3 420852 3352 64074525
Recalled product administered 12.93 10.22 20 420835 736 64077141
Enlarged uvula 12.90 10.22 14 420841 360 64077517
Renal-limited thrombotic microangiopathy 12.90 10.22 5 420850 17 64077860
Spinal osteoarthritis 12.88 10.22 49 420806 14292 64063585
Hypokinesia 12.86 10.22 60 420795 16536 64061341
Hair texture abnormal 12.84 10.22 46 420809 2958 64074919
Hepatitis viral 12.84 10.22 22 420833 883 64076994
Paraparesis 12.80 10.22 51 420804 3451 64074426
Impaired quality of life 12.77 10.22 14 420841 6457 64071420
Drug specific antibody present 12.77 10.22 9 420846 5145 64072732
Clostridium test positive 12.76 10.22 57 420798 4058 64073819
Skin laceration 12.75 10.22 100 420755 24317 64053560
Somnambulism 12.71 10.22 9 420846 5132 64072745
Gastrointestinal wall thinning 12.68 10.22 5 420850 18 64077859
Pneumothorax 12.67 10.22 226 420629 24072 64053805
Hepatitis 12.66 10.22 215 420640 45367 64032510
Femur fracture 12.66 10.22 152 420703 33983 64043894
POEMS syndrome 12.66 10.22 6 420849 37 64077840
Spinal pain 12.63 10.22 132 420723 12489 64065388
Pneumocystis jirovecii infection 12.63 10.22 39 420816 2322 64075555
Pulmonary haemorrhage 12.60 10.22 136 420719 12973 64064904
Acute monocytic leukaemia 12.59 10.22 15 420840 428 64077449
Cachexia 12.56 10.22 103 420752 9114 64068763
Leukaemia 12.55 10.22 66 420789 5022 64072855
Lung squamous cell carcinoma stage II 12.53 10.22 4 420851 6 64077871
Emphysematous cystitis 12.50 10.22 11 420844 217 64077660
Hepatitis B 12.48 10.22 90 420765 7655 64070222
Mood swings 12.48 10.22 65 420790 17403 64060474
Coronavirus infection 12.47 10.22 70 420785 5460 64072417
Refeeding syndrome 12.47 10.22 7 420848 64 64077813
Drug level below therapeutic 12.46 10.22 18 420837 7366 64070511
Dry eye 12.44 10.22 125 420730 28894 64048983
Dermatitis acneiform 12.41 10.22 96 420759 8347 64069530
Skin disorder 12.39 10.22 118 420737 27562 64050315
Perihepatic abscess 12.39 10.22 9 420846 133 64077744
Tracheal deviation 12.38 10.22 7 420848 65 64077812
Tumour flare 12.33 10.22 20 420835 767 64077110
Cryptosporidiosis infection 12.32 10.22 18 420837 629 64077248
Fibrin D dimer increased 12.31 10.22 81 420774 6684 64071193
Insomnia 12.31 10.22 1117 419738 196719 63881158
Gestational diabetes 12.29 10.22 11 420844 5579 64072298
Haemolysis 12.28 10.22 118 420737 10921 64066956
Glomerular filtration rate decreased 12.27 10.22 76 420779 19496 64058381
Drooling 12.26 10.22 10 420845 5309 64072568
Retinal ischaemia 12.25 10.22 19 420836 701 64077176
Blood pressure measurement 12.24 10.22 14 420841 382 64077495
Mesenteric vascular insufficiency 12.22 10.22 9 420846 136 64077741
Middle insomnia 12.22 10.22 43 420812 12834 64065043
Chemotherapy 12.20 10.22 29 420826 1478 64076399
Drug-induced liver injury 12.19 10.22 228 420627 47415 64030462
Ear pain 12.19 10.22 105 420750 25031 64052846
Tendon disorder 12.17 10.22 14 420841 6318 64071559
Skin induration 12.16 10.22 6 420849 4169 64073708
Acanthamoeba keratitis 12.15 10.22 4 420851 7 64077870
Cataract traumatic 12.15 10.22 4 420851 7 64077870
Plasma cells present 12.15 10.22 4 420851 7 64077870
Skin plaque 12.15 10.22 25 420830 8915 64068962
Hypogeusia 12.15 10.22 29 420826 1482 64076395
Electrocardiogram abnormal 12.15 10.22 46 420809 13435 64064442
Onychalgia 12.14 10.22 20 420835 777 64077100
Fibrin increased 12.12 10.22 3 420852 0 64077877
Sensory ganglionitis 12.12 10.22 3 420852 0 64077877
Hymenolepiasis 12.12 10.22 3 420852 0 64077877
Purine metabolism disorder 12.12 10.22 3 420852 0 64077877
General physical condition abnormal 12.10 10.22 69 420786 5413 64072464
Candida sepsis 12.10 10.22 37 420818 2191 64075686
Escherichia urinary tract infection 12.10 10.22 126 420729 11911 64065966
Tachypnoea 12.08 10.22 242 420613 26329 64051548
Mydriasis 12.08 10.22 55 420800 15257 64062620
Herpes zoster reactivation 12.07 10.22 8 420847 101 64077776
Thinking abnormal 12.06 10.22 37 420818 11519 64066358
Acute myelomonocytic leukaemia 12.06 10.22 12 420843 278 64077599
Orthopnoea 12.03 10.22 26 420829 9108 64068769
Haemophilus bacteraemia 12.03 10.22 6 420849 42 64077835
Blood immunoglobulin E increased 12.02 10.22 5 420850 3839 64074038
Concomitant disease aggravated 12.02 10.22 37 420818 11505 64066372
Madarosis 12.02 10.22 38 420817 2292 64075585
Complication associated with device 12.00 10.22 54 420801 15026 64062851
Cystitis haemorrhagic 11.99 10.22 91 420764 7865 64070012
Skin toxicity 11.99 10.22 79 420776 6523 64071354
Macular hole 11.97 10.22 19 420836 715 64077162
Palmar-plantar erythrodysaesthesia syndrome 11.97 10.22 259 420596 28560 64049317
Leishmaniasis 11.92 10.22 13 420842 336 64077541
Blindness 11.91 10.22 206 420649 21813 64056064
Ligament sprain 11.87 10.22 34 420821 10818 64067059
Epstein-Barr virus associated lymphoproliferative disorder 11.87 10.22 46 420809 3073 64074804
Hip deformity 11.85 10.22 10 420845 186 64077691
Brain neoplasm 11.84 10.22 63 420792 4815 64073062
Rales 11.84 10.22 55 420800 15174 64062703
Oropharyngeal pain 11.79 10.22 467 420388 88400 63989477
Cerebellar haemangioma 11.78 10.22 7 420848 72 64077805
Arthropod bite 11.72 10.22 16 420839 6705 64071172
Needle issue 11.72 10.22 27 420828 9245 64068632
Oesophageal candidiasis 11.70 10.22 91 420764 7926 64069951
Chest wall abscess 11.69 10.22 9 420846 146 64077731
Tooth fracture 11.68 10.22 30 420825 9897 64067980
Human rhinovirus test positive 11.68 10.22 14 420841 402 64077475
Mood altered 11.67 10.22 59 420796 15920 64061957
Pulmonary function test decreased 11.66 10.22 15 420840 6446 64071431
Drug reaction with eosinophilia and systemic symptoms 11.65 10.22 267 420588 53950 64023927
Haemorrhagic necrotic pancreatitis 11.61 10.22 7 420848 74 64077803
Complications of transplanted kidney 11.59 10.22 11 420844 5424 64072453
Disseminated blastomycosis 11.56 10.22 8 420847 109 64077768
Affect lability 11.51 10.22 26 420829 8964 64068913
Nasal flaring 11.50 10.22 4 420851 9 64077868
Rhinitis allergic 11.49 10.22 22 420833 8056 64069821
Fungal sepsis 11.42 10.22 30 420825 1628 64076249
Lymphocytic leukaemia 11.41 10.22 10 420845 196 64077681
Blood urea increased 11.39 10.22 211 420644 43942 64033935
Osteochondrosis 11.38 10.22 28 420827 1459 64076418
Major depression 11.37 10.22 21 420834 7795 64070082
Enterococcal sepsis 11.36 10.22 39 420816 2455 64075422
Rash maculo-papular 11.36 10.22 394 420461 46632 64031245
Abortion induced 11.35 10.22 15 420840 6373 64071504
Alveolitis 11.34 10.22 51 420804 3641 64074236
Hyperlactacidaemia 11.30 10.22 9 420846 4835 64073042
Vocal cord paresis 11.29 10.22 10 420845 199 64077678
Diabetes mellitus inadequate control 11.28 10.22 87 420768 21234 64056643
Hepatotoxicity 11.25 10.22 341 420514 39621 64038256
Enteric neuropathy 11.21 10.22 4 420851 10 64077867
Light chain analysis 11.21 10.22 4 420851 10 64077867
Hyperproteinaemia 11.19 10.22 9 420846 156 64077721
Retinal vein thrombosis 11.18 10.22 17 420838 616 64077261
Shock haemorrhagic 11.16 10.22 64 420791 16727 64061150
Squamous cell carcinoma of head and neck 11.15 10.22 11 420844 252 64077625
Vitreous haze 11.15 10.22 7 420848 80 64077797
Limb deformity 11.13 10.22 4 420851 3357 64074520
Thrombophlebitis 11.10 10.22 69 420786 5585 64072292
VIth nerve disorder 11.09 10.22 5 420850 27 64077850
Cognitive disorder 11.08 10.22 274 420581 54813 64023064
Adjusted calcium increased 11.06 10.22 6 420849 51 64077826
Therapy responder 11.03 10.22 14 420841 427 64077450
Tongue disorder 11.03 10.22 41 420814 12039 64065838
Bone marrow disorder 11.02 10.22 42 420813 2783 64075094
Intraductal proliferative breast lesion 11.02 10.22 35 420820 2116 64075761
Diabetic metabolic decompensation 11.01 10.22 41 420814 2687 64075190
Dissociation 11.01 10.22 3 420852 3008 64074869
High density lipoprotein decreased 11.01 10.22 6 420849 3940 64073937
Osteopenia 11.00 10.22 58 420797 15482 64062395
Thiopurine methyltransferase decreased 10.98 10.22 12 420843 311 64077566
Streptococcal infection 10.97 10.22 85 420770 7394 64070483
Immunodeficiency 10.96 10.22 61 420794 16063 64061814
Agitation 10.95 10.22 468 420387 87899 63989978
Precursor T-lymphoblastic lymphoma/leukaemia recurrent 10.94 10.22 4 420851 11 64077866
Uterine fistula 10.94 10.22 4 420851 11 64077866
Viraemia 10.94 10.22 37 420818 2312 64075565
Pneumonia legionella 10.93 10.22 38 420817 2408 64075469
Gingival erosion 10.91 10.22 8 420847 120 64077757
Polychromasia 10.91 10.22 11 420844 259 64077618
Adenoviral haemorrhagic cystitis 10.89 10.22 15 420840 496 64077381
Infusion site streaking 10.88 10.22 14 420841 433 64077444
Haemodialysis 10.87 10.22 66 420789 17011 64060866
Epstein-Barr viraemia 10.87 10.22 31 420824 1766 64076111
Calciphylaxis 10.86 10.22 4 420851 3308 64074569
Electrocardiogram Q waves 10.86 10.22 7 420848 84 64077793
Leukaemic lymphoma 10.86 10.22 7 420848 84 64077793
Peripheral arterial occlusive disease 10.86 10.22 18 420837 6969 64070908
Limb discomfort 10.86 10.22 119 420736 27056 64050821
Epstein-Barr virus infection 10.85 10.22 127 420728 12361 64065516
Hyperthermia malignant 10.81 10.22 38 420817 2421 64075456
Dysstasia 10.81 10.22 98 420757 23117 64054760
Haemophilus sepsis 10.80 10.22 5 420850 29 64077848
Bone marrow leukaemic cell infiltration 10.80 10.22 5 420850 29 64077848
Body temperature fluctuation 10.79 10.22 4 420851 3294 64074583
Muscle haemorrhage 10.75 10.22 13 420842 5740 64072137
Bladder transitional cell carcinoma stage 0 10.75 10.22 8 420847 123 64077754
Gallbladder disorder 10.74 10.22 66 420789 16964 64060913
Opportunistic infection 10.74 10.22 40 420815 2622 64075255
Encephalopathy 10.73 10.22 478 420377 58341 64019536
Radiation mucositis 10.72 10.22 9 420846 166 64077711
Feeling drunk 10.69 10.22 7 420848 4160 64073717
Corneal lesion 10.68 10.22 6 420849 55 64077822
Injection site extravasation 10.67 10.22 23 420832 8063 64069814
Dermatitis atopic 10.66 10.22 6 420849 3870 64074007
Paranoid personality disorder 10.66 10.22 5 420850 30 64077847
Sinus polyp 10.66 10.22 14 420841 442 64077435
Pancreatic carcinoma metastatic 10.65 10.22 48 420807 3430 64074447
Focal segmental glomerulosclerosis 10.64 10.22 3 420852 2941 64074936
Ichthyosis 10.64 10.22 8 420847 125 64077752
SARS-CoV-2 sepsis 10.64 10.22 8 420847 125 64077752
Tooth erosion 10.61 10.22 13 420842 382 64077495
Exposed bone in jaw 10.59 10.22 48 420807 3439 64074438
Hypersensitivity 10.57 10.22 1121 419734 195331 63882546
Abdominal pain lower 10.54 10.22 116 420739 26353 64051524
Gastritis erosive 10.54 10.22 30 420825 9565 64068312
Throat irritation 10.54 10.22 150 420705 32561 64045316
Peritonitis viral 10.50 10.22 6 420849 57 64077820
Bone infarction 10.48 10.22 13 420842 387 64077490
Staphylococcal scalded skin syndrome 10.48 10.22 13 420842 387 64077490
Wrist fracture 10.46 10.22 32 420823 9969 64067908
Bronchiectasis 10.45 10.22 52 420803 14088 64063789
Botryomycosis 10.41 10.22 6 420849 58 64077819
Tumour pain 10.41 10.22 32 420823 1901 64075976
Mucosal erosion 10.40 10.22 32 420823 1902 64075975
Cardiac failure 10.39 10.22 1001 419854 131372 63946505
Radiation inflammation 10.39 10.22 10 420845 222 64077655
Coronary artery stenosis 10.38 10.22 38 420817 11210 64066667
Urticaria papular 10.38 10.22 8 420847 130 64077747
Mucocutaneous haemorrhage 10.37 10.22 9 420846 174 64077703
Bradypnoea 10.36 10.22 11 420844 5148 64072729
Fungal disease carrier 10.35 10.22 11 420844 276 64077601
Oesophageal squamous cell carcinoma 10.35 10.22 14 420841 455 64077422
Petechiae 10.34 10.22 175 420680 18451 64059426
Suicidal behaviour 10.33 10.22 3 420852 2884 64074993
Rhinorrhoea 10.31 10.22 305 420550 59664 64018213
Accident 10.31 10.22 18 420837 6828 64071049
Systemic mycosis 10.30 10.22 36 420819 2287 64075590
Wrong technique in device usage process 10.30 10.22 3 420852 2879 64074998
Haemorrhagic stroke 10.29 10.22 32 420823 9919 64067958
Tooth deposit 10.29 10.22 10 420845 225 64077652
Bradycardia 10.28 10.22 649 420206 117570 63960307
Idiopathic pulmonary fibrosis 10.28 10.22 6 420849 3794 64074083
Drug clearance decreased 10.27 10.22 39 420816 2580 64075297
Natural killer-cell lymphoblastic lymphoma 10.27 10.22 5 420850 33 64077844
Human herpesvirus 7 infection 10.26 10.22 7 420848 93 64077784
Hordeolum 10.25 10.22 35 420820 2197 64075680
Plasmablastic lymphoma 10.25 10.22 13 420842 396 64077481
Refractory cancer 10.25 10.22 10 420845 226 64077651
Hand fracture 10.23 10.22 10 420845 4864 64073013
Periorbital cellulitis 10.23 10.22 18 420837 738 64077139
Varices oesophageal 10.23 10.22 11 420844 5119 64072758

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AC02 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Corticosteroids for local oral treatment
ATC C05AA09 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AB19 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC D07CB04 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, moderately potent, combinations with antibiotics
ATC D07XB05 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, moderately potent, other combinations
ATC D10AA03 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Corticosteroids, combinations for treatment of acne
ATC H02AB02 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD03 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R01AD53 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC S01BA01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01CA01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S01CB01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA06 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC S02CA06 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S03BA01 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS
Corticosteroids
ATC S03CA01 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000932 Antiemetics
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:37962 adrenergic agents
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Otitis externa indication 3135009
Keratitis indication 5888003 DOID:4677
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Cyclitis indication 17657000
Systemic AL amyloidosis indication 23132008
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Keloid scar indication 33659008
Crohn's disease indication 34000006
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Punctate keratitis indication 42513006 DOID:12197
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Lรถffler's syndrome indication 64936001 DOID:9503
Iritis indication 65074000 DOID:1406
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Blepharoconjunctivitis indication 68659002 DOID:2456
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Perforation of cornea indication 74895004
Iridocyclitis indication 77971008
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Corneal abrasion indication 85848002
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Corneal ulcer indication 91514001 DOID:8463
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Multiple myeloma indication 109989006 DOID:9538
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Mycosis fungoides indication 118618005
Uveitis indication 128473001 DOID:13141
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Central retinal vein occlusion with macular edema indication 232039004
Branch retinal vein occlusion with macular edema indication 232048009
Malignant otitis externa due to Pseudomonas aeruginosa indication 232230009
Scalp psoriasis indication 238608008
Punctate keratopathy indication 246936005
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Infective otitis media indication 312218008
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Herpes zoster keratitis indication 397573005
Rosacea indication 398909004 DOID:8881
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Allergic otitis externa indication 405821001
Anterior uveitis indication 410692006 DOID:1407
Autoimmune hemolytic anemia indication 413603009 DOID:718
Allergic conjunctivitis indication 473460002 DOID:11204
Transfusion Reaction Urticaria indication
Erythroblastic Anemia indication
Synovitis due to Osteoarthritis indication
Post-Op Ocular Inflammation indication
Tuberculosis Meningitis Treatment Adjunct indication
Non-infectious Posterior Uveitis indication
Staphylococcus Aureus Otitis Externa indication
Progressive Diffuse Large B-Cell Lymphoma indication
Otitis Externa Seborrhea indication
Diagnostic Test for Cushing's Syndrome indication
Otitis Externa Eczema indication
Systemic Dermatomyositis indication
Pericarditis off-label use 3238004 DOID:1787
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Tendinitis off-label use 34840004 DOID:971
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Croup off-label use 71186008 DOID:9395
Pemphigoid off-label use 86142006
Myasthenia gravis off-label use 91637004 DOID:437
Polyarteritis nodosa off-label use 155441006 DOID:9810
Chemotherapy-induced nausea and vomiting off-label use 236084000
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Prevention of Post-Operative Nausea and Vomiting off-label use
Metastatic Prostate Carcinoma off-label use
Prevention of Radiation-Induced Nausea and Vomiting off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Endophthalmitis contraindication 1847009 DOID:4692
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Herpes simplex keratitis contraindication 9389005
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Glaucoma contraindication 23986001 DOID:1686
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Severe myopia contraindication 34187009
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Retinal detachment contraindication 42059000 DOID:5327
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Bacterial infection of eye contraindication 128984004
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Injury of eye region contraindication 282752000
Varicella-zoster virus infection contraindication 309465005
Viral eye infection contraindication 312132001
Viral ear infection contraindication 312137007
Osteopenia contraindication 312894000
Vaccinia keratitis contraindication 397552005
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Arginosuccinate Lyase Deficiency contraindication
Ornithine Carbamyltransferase Deficiency contraindication




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Cats Inflammation Indication
Cattle Primary bovine ketosis Indication
Cattle Inflammation Indication
Dogs Inflammation Indication
Horses Inflammation Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Azium Tablets 0.25 mg Intervet Inc. 1
Azium Aqueous Suspension Veterinary Intervet Inc. 1
Azium Solution Intervet Inc. 1
Naquasone Bolus Intervet Inc. 2
Azium Powder Intervet Inc. 1
Azium Boluses 10 mg Intervet Inc. 1
Tresaderm Dermatologic Solution Boehringer lngelheim Animal Health USA Inc. 3
Azium Oral Solution 2 mg Intervet Inc. 1
Dexium Tablets Bimeda Animal Health Limited 1
Dexameth-A-Vet Injection Bimeda Animal Health Limited 1
Dexameth-A-Vet Bimeda Animal Health Limited 1
Pet Derm III Tablets Kinetic Technologies LLC 1
Dexamethasone Sterile Solution Kinetic Technologies LLC 1
Zonometh Solution Huvepharma EOOD 1
Dexachel Zoetis Inc. 1
Dexamethasone Solution Huvepharma EOOD 1
Dexium Bimeda Animal Health Limited 1
Dexamethasone Injection Sparhawk Laboratories Inc. 1
Dexamethasone Solution Med-Pharmex Inc. 1
Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Dechra Veterinary Products LLC 3

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 12.45 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.3%;0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 9149486 Sept. 13, 2022 TREATMENT OF ACUTE OTITIS MEDIA
0.3%;0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 9345714 Sept. 13, 2022 TREATMENT OF ACUTE OTITIS MEDIA
0.3%;0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 9402805 Sept. 13, 2022 TREATMENT OF ACUTE OTITIS EXTERNA
0.3%;0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 9402805 Sept. 13, 2022 TREATMENT OF ACUTE OTITIS MEDIA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 10702539 Jan. 9, 2023 TREATMENT OF DIABETIC MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 10702539 Jan. 9, 2023 TREATMENT OF MACULAR EDEMA FOLLOWING BRANCH RETINAL VEIN OCCLUSION (BRVO) OR CENTRAL RETINAL VEIN OCCLUSION (CRVO)
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 10702539 Jan. 9, 2023 TREATMENT OF NON-INFECTIOUS UVEITIS AFFECTING THE POSTERIOR SEGMENT OF THE EYE
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8034366 Jan. 9, 2023 TREATMENT OF MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8034366 Jan. 9, 2023 TREATMENT OF UVEITIS
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8506987 Jan. 9, 2023 TREATMENT OF MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8506987 Jan. 9, 2023 TREATMENT OF UVEITIS
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 6899717 Nov. 1, 2023 DELIVERING AN OCULAR IMPLANT AS DESCRIBED IN THE DOSAGE AND ADMINISTRATION SECTION OF THE APPROVED LABELING OF OZURDEX
0.3%;0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 8846650 June 4, 2025 TREATMENT OF ACUTE OTITIS MEDIA
0.05%;0.3% TOBRADEX ST EYEVANCE N050818 Feb. 13, 2009 RX SUSPENSION/DROPS OPHTHALMIC 8101582 Dec. 19, 2027 USE OF A COMBINATION OF TOBRAMYCIN AND DEXAMETHASONE TO TREAT OCULAR INFLAMMATION WHERE AN INFECTION OR RISK OF INFECTION EXISTS
0.05%;0.3% TOBRADEX ST EYEVANCE N050818 Feb. 13, 2009 RX SUSPENSION/DROPS OPHTHALMIC 7795316 Aug. 3, 2028 USE OF A COMBINATION OF TOBRAMYCIN AND DEXAMETHASONE TO TREAT OCULAR INFLAMMATION WHERE AN INFECTION OR RISK OF INFECTION EXISTS
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC 8563027 Feb. 12, 2030 DEXTENZA IS APPROVED FOR THE TREATMENT OF OCULAR PAIN FOLLOWING OPHTHALMIC SURGERY
9% DEXYCU KIT EYEPOINT PHARMS N208912 Feb. 9, 2018 RX SUSPENSION INTRAOCULAR 10028965 May 23, 2034 TREATMENT OF POSTOPERATIVE INFLAMMATION
9% DEXYCU KIT EYEPOINT PHARMS N208912 Feb. 9, 2018 RX SUSPENSION INTRAOCULAR 10022502 June 22, 2034 TREATMENT OF POSTOPERATIVE INFLAMMATION
20MG HEMADY DEXCEL PHARMA N211379 Oct. 3, 2019 RX TABLET ORAL 11304961 Dec. 18, 2037 A METHOD OF TREATING ADULTS WITH MULTIPLE MYELOMA USING DEXAMETHASONE IN COMBINATION WITH AN ANTI-MYELOMA PRODUCT

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
6MG DEXAMETHASONE AMNEAL A215106 Oct. 14, 2021 RX TABLET ORAL April 19, 2022 COMPETITIVE GENERIC THERAPY
4MG DEXAMETHASONE AMNEAL A215106 Oct. 14, 2021 RX TABLET ORAL April 20, 2022 COMPETITIVE GENERIC THERAPY
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC June 20, 2022 TREATMENT OF OCULAR INFLAMMATION FOLLOWING OPHTHALMIC SURGERY
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC Oct. 7, 2024 TREATMENT OF OCULAR ITCHING ASSOCIATED WITH ALLERGIC CONJUNCTIVITIS
20MG HEMADY DEXCEL PHARMA N211379 Oct. 3, 2019 RX TABLET ORAL Oct. 3, 2026 INDICATED IN COMBINATION WITH OTHER ANTI-MYELOMA PRODUCTS FOR THE TREATMENT OF ADULTS WITH MULTIPLE MYELOMA (MM)

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8.88 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK
Interleukin-5 Cytokine IC50 8.46 WOMBAT-PK
Mineralocorticoid receptor Nuclear hormone receptor EC50 9 WOMBAT-PK
Interleukin-4 Cytokine IC50 8.33 WOMBAT-PK
Androgen receptor Nuclear hormone receptor Ki 5.85 CHEMBL
Progesterone receptor Nuclear hormone receptor Ki 6.25 CHEMBL
Prostaglandin G/H synthase 2 Enzyme Ki 6.89 PDSP
Androgen receptor Transcription factor Ki 4.79 DRUG MATRIX
Fatty acid-binding protein, liver Unclassified Ki 4.66 CHEMBL
Progesterone receptor Transcription factor Ki 5.52 DRUG MATRIX
Glucocorticoid receptor Transcription factor IC50 7.66 CHEMBL
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor AGONIST EC50 6.10 IUPHAR

External reference:

IDSource
4017922 VUID
N0000146273 NUI
D00292 KEGG_DRUG
203704 RXNORM
4017922 VANDF
C0011777 UMLSCUI
CHEBI:41879 CHEBI
DEX PDB_CHEM_ID
CHEMBL384467 ChEMBL_ID
CHEMBL2021430 ChEMBL_ID
CHEMBL1200637 ChEMBL_ID
DB01234 DRUGBANK_ID
D003907 MESH_DESCRIPTOR_UI
5743 PUBCHEM_CID
2768 IUPHAR_LIGAND_ID
816 INN_ID
7S5I7G3JQL UNII
4552 MMSL
6848 MMSL
6849 MMSL
d00206 MMSL
002174 NDDF
372584003 SNOMEDCT_US
7561000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
OZURDEX HUMAN PRESCRIPTION DRUG LABEL 1 0023-3348 IMPLANT 0.70 mg INTRAVITREAL NDA 24 sections
Dexamethasone Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3176 SOLUTION, CONCENTRATE 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-3177 SOLUTION 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4179 TABLET 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4180 TABLET 0.75 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4181 TABLET 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4182 TABLET 1.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4183 TABLET 2 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4184 TABLET 4 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4186 TABLET 6 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8174 TABLET 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8175 TABLET 4 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8176 TABLET 2 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8179 TABLET 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8180 TABLET 0.75 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8181 TABLET 1.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8183 TABLET 6 mg ORAL ANDA 20 sections
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0065-0631 OINTMENT 1 mg OPHTHALMIC NDA 18 sections
TobraDex HUMAN PRESCRIPTION DRUG LABEL 2 0065-0647 SUSPENSION/ DROPS 1 mg OPHTHALMIC NDA 18 sections
TobraDex HUMAN PRESCRIPTION DRUG LABEL 2 0065-0648 OINTMENT 1 mg OPHTHALMIC NDA 18 sections
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0078-0771 OINTMENT 1 mg OPHTHALMIC NDA 18 sections
CIPRODEX HUMAN PRESCRIPTION DRUG LABEL 2 0078-0799 SUSPENSION/ DROPS 1 mg AURICULAR (OTIC) NDA 28 sections
CIPRODEX HUMAN PRESCRIPTION DRUG LABEL 2 0078-0799 SUSPENSION/ DROPS 1 mg AURICULAR (OTIC) NDA 28 sections
TobraDex HUMAN PRESCRIPTION DRUG LABEL 2 0078-0876 OINTMENT 1 mg OPHTHALMIC NDA 18 sections
TobraDex HUMAN PRESCRIPTION DRUG LABEL 2 0078-0953 SUSPENSION/ DROPS 1 mg OPHTHALMIC NDA 18 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0095-0087 TABLET 1.50 mg ORAL ANDA 23 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0095-0088 TABLET 1.50 mg ORAL ANDA 23 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0095-0089 TABLET 1.50 mg ORAL ANDA 23 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0121-0907 SOLUTION 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0121-1814 SOLUTION 1 mg ORAL ANDA 20 sections