dexamethasone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 824 50-02-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexamethasone
  • dexasone
  • dexmethsone
An anti-inflammatory 9-fluoro-glucocorticoid. The NIH COVID-19 Treatment Guidelines Panel recommends the use of dexamethasone in patients with COVID-19 who are receiving mechanical ventilation or in those who require supplemental oxygen but are not on me-chanical ventilation. It is not recommended the use of dexamethasone or other corticosteroids in nonhospitalized patients with mild to moderate COVID-19 or in hospitalized patients with COVID-19 who do not require supplemental oxygen.
  • Molecular weight: 392.47
  • Formula: C22H29FO5
  • CLOGP: 1.79
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.89
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 mg O
1.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.09 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2.60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.33 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.94 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.32 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 30, 1958 FDA
Aug. 25, 2021 PMDA NICHI - IKO PHARMACEUTICAL Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 5449.33 9.96 3266 270257 44608 53030935
Neuropathy peripheral 1662.32 9.96 2332 271191 100855 52974688
Neutropenia 1503.78 9.96 2823 270700 156362 52919181
Febrile neutropenia 1272.33 9.96 2078 271445 102858 52972685
Rheumatoid arthritis 1203.36 9.96 113 273410 314418 52761125
Thrombocytopenia 1136.54 9.96 2318 271205 136409 52939134
Diarrhoea 737.39 9.96 5597 267926 619949 52455594
Drug ineffective 660.87 9.96 2081 271442 815164 52260379
Completed suicide 648.51 9.96 12 273511 138189 52937354
Pneumonia 597.31 9.96 3846 269677 403323 52672220
Platelet count decreased 552.34 9.96 1503 272020 106596 52968947
Constipation 504.43 9.96 2184 271339 196228 52879315
Plasma cell myeloma recurrent 499.75 9.96 256 273267 2501 53073042
White blood cell count decreased 474.98 9.96 1561 271962 122914 52952629
Systemic lupus erythematosus 473.70 9.96 47 273476 125367 52950176
Disease progression 472.41 9.96 1368 272155 100552 52974991
Full blood count decreased 460.87 9.96 592 272931 23437 53052106
Death 443.34 9.96 3240 270283 353992 52721551
Contraindicated product administered 428.22 9.96 87 273436 135542 52940001
Neutrophil count decreased 425.82 9.96 841 272682 48257 53027286
Pemphigus 411.80 9.96 32 273491 103999 52971544
Drug hypersensitivity 393.08 9.96 469 273054 264773 52810770
Pancytopenia 381.10 9.96 1178 272345 89750 52985793
Pain 357.19 9.96 1679 271844 586719 52488824
Arthralgia 347.86 9.96 1128 272395 438655 52636888
Injection site pain 337.25 9.96 83 273440 113308 52962235
Anaemia 334.34 9.96 2495 271028 274223 52801320
Condition aggravated 329.82 9.96 640 272883 296494 52779049
Plasmacytoma 326.85 9.96 189 273334 2392 53073151
Therapeutic product effect decreased 324.76 9.96 119 273404 125536 52950007
Sepsis 323.40 9.96 1547 271976 144882 52930661
Hand deformity 322.44 9.96 31 273492 84818 52990725
Thrombosis 303.98 9.96 839 272684 59954 53015589
Mucosal inflammation 298.96 9.96 671 272852 42113 53033430
Intentional overdose 292.48 9.96 12 273511 67193 53008350
Psoriasis 287.33 9.96 50 273473 87039 52988504
Leukopenia 286.00 9.96 928 272595 72535 53003008
Deep vein thrombosis 282.00 9.96 1001 272522 81912 52993631
Unevaluable event 275.64 9.96 711 272812 48787 53026756
Arthropathy 264.26 9.96 203 273320 141250 52934293
Synovitis 257.89 9.96 115 273408 107778 52967765
Neutropenic sepsis 253.20 9.96 343 273180 14306 53061237
Abdominal discomfort 250.49 9.96 470 273053 220592 52854951
Overdose 249.50 9.96 120 273403 107616 52967927
Glossodynia 247.51 9.96 102 273421 100189 52975354
Cytopenia 238.63 9.96 264 273259 8906 53066637
Laboratory test abnormal 236.02 9.96 438 273085 23971 53051572
Drug abuse 233.65 9.96 30 273493 65496 53010047
Febrile bone marrow aplasia 220.76 9.96 226 273297 6963 53068580
Tumour lysis syndrome 214.12 9.96 232 273291 7642 53067901
Anti-cyclic citrullinated peptide antibody positive 211.72 9.96 23 273500 57149 53018394
Headache 205.83 9.96 1763 271760 535058 52540485
Suicide attempt 204.13 9.96 28 273495 58140 53017403
Joint swelling 200.58 9.96 580 272943 234058 52841485
Plasma cell leukaemia 193.58 9.96 104 273419 1129 53074414
Pulmonary embolism 190.04 9.96 1118 272405 113324 52962219
Injection site erythema 189.89 9.96 79 273444 77170 52998373
Swelling 189.69 9.96 438 273085 190667 52884876
Pericarditis 187.87 9.96 49 273474 64357 53011186
Septic shock 186.17 9.96 721 272802 61508 53014035
Peripheral sensory neuropathy 181.20 9.96 203 273320 6945 53068598
Malignant neoplasm progression 179.41 9.96 785 272738 70756 53004787
Pyrexia 175.67 9.96 2972 270551 400221 52675322
Wound 175.30 9.96 128 273395 91429 52984114
Fatigue 173.68 9.96 4933 268590 725573 52349970
Treatment failure 172.46 9.96 244 273279 128159 52947384
Maternal exposure during pregnancy 170.01 9.96 338 273185 155301 52920242
Musculoskeletal stiffness 168.12 9.96 232 273291 123136 52952407
Abortion spontaneous 167.11 9.96 21 273502 46614 53028929
Polyneuropathy 161.26 9.96 263 273260 12970 53062573
Hepatic enzyme increased 158.62 9.96 251 273272 125944 52949599
Psoriatic arthropathy 158.19 9.96 28 273495 48162 53027381
Discomfort 154.16 9.96 157 273366 95315 52980228
Asthenia 150.74 9.96 2536 270987 341054 52734489
Multiple sclerosis relapse 147.36 9.96 26 273497 44827 53030716
Haemophagocytic lymphohistiocytosis 144.50 9.96 205 273318 8932 53066611
Posterior reversible encephalopathy syndrome 143.89 9.96 280 273243 15880 53059663
Injection site reaction 143.48 9.96 42 273481 51124 53024419
Bone marrow failure 142.98 9.96 408 273115 29707 53045836
Rheumatoid factor positive 141.81 9.96 21 273502 41177 53034366
Drug intolerance 138.83 9.96 562 272961 204931 52870612
Knee arthroplasty 136.60 9.96 9 273514 33560 53041983
Depression 136.38 9.96 481 273042 182571 52892972
Off label use 135.31 9.96 3270 270253 468942 52606601
Loss of personal independence in daily activities 133.12 9.96 98 273425 69717 53005826
Venoocclusive liver disease 131.88 9.96 139 273384 4433 53071110
Dehydration 127.29 9.96 1372 272151 167038 52908505
Endophthalmitis 127.26 9.96 122 273401 3465 53072078
Muscle injury 127.23 9.96 6 273517 29760 53045783
Asthma 126.55 9.96 228 273295 108744 52966799
Suicidal ideation 126.04 9.96 77 273446 60434 53015109
Flushing 124.51 9.96 701 272822 69899 53005644
Inappropriate schedule of product administration 124.48 9.96 120 273403 74758 53000785
Acute lymphocytic leukaemia recurrent 123.30 9.96 98 273425 2150 53073393
Injection site swelling 121.36 9.96 34 273489 42594 53032949
Injection site pruritus 120.60 9.96 32 273491 41557 53033986
Osteoarthritis 119.47 9.96 111 273412 70375 53005168
Wrong technique in product usage process 118.75 9.96 81 273442 59951 53015592
Light chain analysis increased 117.82 9.96 74 273449 1098 53074445
Monoclonal immunoglobulin present 117.42 9.96 65 273458 752 53074791
Intentional product misuse 117.42 9.96 53 273470 49339 53026204
Metastases to central nervous system 117.35 9.96 217 273306 11840 53063703
Injection site bruising 116.97 9.96 25 273498 37621 53037922
Bone pain 114.77 9.96 540 272983 50182 53025361
Haematotoxicity 113 9.96 169 273354 7728 53067815
Neurotoxicity 111.99 9.96 245 273278 15104 53060439
Intentional self-injury 111.75 9.96 4 273519 25280 53050263
Therapeutic product effect incomplete 111.15 9.96 187 273336 91597 52983946
Mobility decreased 110.47 9.96 137 273386 76134 52999409
Helicobacter infection 107.85 9.96 33 273490 39036 53036507
Sleep disorder due to general medical condition, insomnia type 107.10 9.96 4 273519 24345 53051198
Osteonecrosis 106.33 9.96 339 273184 26236 53049307
Irritable bowel syndrome 105.00 9.96 46 273477 43586 53031957
Pneumocystis jirovecii pneumonia 100.29 9.96 244 273279 16134 53059409
COVID-19 pneumonia 100.01 9.96 152 273371 7051 53068492
C-reactive protein abnormal 96.81 9.96 10 273513 25860 53049683
Decreased appetite 96.37 9.96 1593 271930 213381 52862162
COVID-19 95.68 9.96 409 273114 36479 53039064
Folliculitis 94.63 9.96 23 273500 31686 53043857
Hospitalisation 94.25 9.96 136 273387 70876 53004667
Drug interaction 93.50 9.96 699 272824 218630 52856913
Hip arthroplasty 91.85 9.96 16 273507 27846 53047697
Migraine 91.80 9.96 170 273353 80247 52995296
Drug withdrawal syndrome 90.42 9.96 17 273506 28005 53047538
Duodenal ulcer perforation 89.69 9.96 34 273489 35149 53040394
Sinusitis 89.22 9.96 503 273020 168061 52907482
Stress 88.62 9.96 97 273426 56987 53018556
Myelodysplastic syndrome 87.28 9.96 234 273289 16426 53059117
Cardiac amyloidosis 87.01 9.96 51 273472 663 53074880
Ageusia 84.92 9.96 195 273328 12419 53063124
Impaired healing 84.19 9.96 124 273399 64081 53011462
Blood potassium decreased 83.09 9.96 419 273104 40041 53035502
Pneumonitis 81.28 9.96 344 273179 30544 53044999
Acute lymphocytic leukaemia 80.68 9.96 86 273437 2779 53072764
Myocardial infarction 79.46 9.96 253 273270 99101 52976442
Injury 78.70 9.96 87 273436 50884 53024659
Diffuse large B-cell lymphoma recurrent 78.51 9.96 67 273456 1629 53073914
Fall 78.47 9.96 1329 272194 357111 52718432
Taste disorder 78.29 9.96 144 273379 7824 53067719
Dysgeusia 78.14 9.96 430 273093 42501 53033042
Hyperglycaemia 77.38 9.96 408 273115 39676 53035867
Therapy partial responder 75.78 9.96 123 273400 6040 53069503
Cytokine release syndrome 75.00 9.96 143 273380 7986 53067557
Multiple sclerosis 74.83 9.96 23 273500 27130 53048413
Pregnancy 74.32 9.96 34 273489 31407 53044136
Corneal oedema 73.97 9.96 68 273455 1829 53073714
Hypoglycaemia 73.52 9.96 118 273405 58895 53016648
Surgery 73.35 9.96 36 273487 31928 53043615
Gait disturbance 73.13 9.96 495 273028 158347 52917196
Pain in extremity 70.73 9.96 1032 272491 284018 52791525
Pulmonary arterial hypertension 69.48 9.96 26 273497 27096 53048447
Coronary artery disease 68.99 9.96 43 273480 33394 53042149
Ill-defined disorder 67.29 9.96 93 273430 49351 53026192
Back pain 67.05 9.96 1623 271900 232624 52842919
Erythema 65.85 9.96 1151 272372 155818 52919725
Respiratory syncytial virus infection 65.06 9.96 106 273417 5222 53070321
Anaphylactic shock 64.89 9.96 253 273270 21640 53053903
Product use in unapproved indication 64.67 9.96 869 272654 111420 52964123
Arthritis 63.87 9.96 231 273292 87067 52988476
Osteolysis 63.69 9.96 75 273448 2710 53072833
Adverse drug reaction 63.61 9.96 482 273041 53143 53022400
Haemoglobin decreased 62.76 9.96 1021 272502 136286 52939257
Coma 61.70 9.96 141 273382 61642 53013901
Sleep apnoea syndrome 61.64 9.96 28 273495 25974 53049569
Incorrect dose administered 60.86 9.96 105 273418 50940 53024603
Palmar-plantar erythrodysaesthesia syndrome 60.28 9.96 245 273278 21361 53054182
Injection site haemorrhage 60.19 9.96 19 273504 22032 53053511
Exposure during pregnancy 60.03 9.96 384 273139 124476 52951067
Blister 59.89 9.96 205 273318 78548 52996995
Red blood cell sedimentation rate increased 59.40 9.96 35 273488 28022 53047521
Pulmonary thrombosis 59.40 9.96 129 273394 7912 53067631
Multiple organ dysfunction syndrome 58.67 9.96 487 273036 55190 53020353
Large intestine perforation 58.55 9.96 128 273395 7886 53067657
Cataract 58.29 9.96 445 273078 49175 53026368
Muscle spasticity 57.17 9.96 11 273512 17827 53057716
Protein total increased 56.89 9.96 69 273454 2573 53072970
Accidental exposure to product 55.33 9.96 26 273497 23648 53051895
Product quality issue 55.19 9.96 65 273458 36958 53038585
Brain oedema 55.19 9.96 174 273349 13384 53062159
Alopecia 55.16 9.96 858 272665 233725 52841818
Chronic obstructive pulmonary disease 55.02 9.96 147 273376 60926 53014617
Lactic acidosis 54.89 9.96 66 273457 37187 53038356
Aplasia 54.75 9.96 86 273437 4106 53071437
Hypokalaemia 54.36 9.96 744 272779 95773 52979770
Colitis ulcerative 54.27 9.96 20 273503 21041 53054502
Cytomegalovirus infection reactivation 54.06 9.96 66 273457 2478 53073065
Herpes simplex encephalitis 53.66 9.96 28 273495 285 53075258
Pneumonia influenzal 53.13 9.96 53 273470 1582 53073961
Clostridium difficile colitis 52.68 9.96 221 273302 19544 53055999
Multiple allergies 52.48 9.96 127 273396 8368 53067175
Nausea 52.39 9.96 4526 268997 751565 52323978
Corneal decompensation 51.37 9.96 16 273507 31 53075512
Fibromyalgia 51.33 9.96 92 273431 43983 53031560
Cytomegalovirus infection 50.93 9.96 217 273306 19322 53056221
Hypoxia 50.37 9.96 471 273052 55209 53020334
Device issue 50.29 9.96 24 273499 21634 53053909
Poisoning 50.19 9.96 6 273517 13844 53061699
Pathological fracture 49.98 9.96 124 273399 8300 53067243
Hepatitis B reactivation 49.15 9.96 56 273467 1952 53073591
Anxiety 49.14 9.96 711 272812 195993 52879550
Hyperviscosity syndrome 49.13 9.96 23 273500 181 53075362
Muscle spasms 49.07 9.96 967 272556 133828 52941715
Impaired work ability 48.91 9.96 7 273516 14083 53061460
Bronchospasm 48.54 9.96 191 273332 16407 53059136
Substance-induced psychotic disorder 48.17 9.96 52 273471 1705 53073838
Joint range of motion decreased 48.07 9.96 16 273507 17940 53057603
Osteoporosis 48.05 9.96 104 273419 46356 53029187
Bacteraemia 47.98 9.96 182 273341 15367 53060176
Product complaint 47.83 9.96 4 273519 12253 53063290
International normalised ratio increased 47.68 9.96 109 273414 47652 53027891
Hypofibrinogenaemia 47.54 9.96 43 273480 1132 53074411
Colitis 47.33 9.96 370 273153 41182 53034361
Blood pressure systolic increased 47.03 9.96 67 273456 35110 53040433
Paraesthesia 46.83 9.96 916 272607 126599 52948944
Injection site warmth 46.82 9.96 8 273515 14120 53061423
Sopor 46.51 9.96 25 273498 21059 53054484
Product substitution issue 46.39 9.96 12 273511 15854 53059689
Myelosuppression 46.26 9.96 158 273365 12670 53062873
Rhabdomyolysis 45.69 9.96 98 273425 43825 53031718
Dry skin 45.43 9.96 395 273128 45365 53030178
Withdrawal syndrome 45.42 9.96 21 273502 19280 53056263
Laryngospasm 44.90 9.96 65 273458 2885 53072658
No adverse event 44.80 9.96 83 273440 39182 53036361
Escherichia bacteraemia 44.79 9.96 69 273454 3239 53072304
Lymphopenia 44.63 9.96 188 273335 16655 53058888
Amyloidosis 44.53 9.96 41 273482 1105 53074438
Injection site urticaria 44.38 9.96 6 273517 12601 53062942
Obesity 44.34 9.96 15 273508 16647 53058896
Weight increased 44.18 9.96 760 272763 203807 52871736
Somnolence 44.12 9.96 600 272923 167134 52908409
Foot deformity 44.01 9.96 20 273503 18548 53056995
Ejection fraction decreased 43.92 9.96 210 273313 19638 53055905
Right ventricular failure 43.39 9.96 16 273507 16827 53058716
Blood pressure fluctuation 43.17 9.96 72 273451 35398 53040145
Palpitations 42.69 9.96 328 273195 102020 52973523
Neutrophil count abnormal 42.64 9.96 60 273463 2594 53072949
Iron deficiency anaemia 42.52 9.96 21 273502 18559 53056984
Injection site mass 42.45 9.96 15 273508 16199 53059344
Carpal tunnel syndrome 42.32 9.96 19 273504 17748 53057795
Injection site rash 42.29 9.96 16 273507 16563 53058980
Sedation 42.23 9.96 54 273469 29621 53045922
Human chorionic gonadotropin increased 41.98 9.96 42 273481 1258 53074285
Febrile infection 41.95 9.96 42 273481 1259 53074284
Influenza like illness 41.94 9.96 165 273358 60694 53014849
Hypertriglyceridaemia 41.93 9.96 97 273426 6207 53069336
Systemic candida 41.72 9.96 64 273459 2993 53072550
Sleep disorder 41.60 9.96 158 273365 58712 53016831
Lacrimation increased 41.50 9.96 192 273331 17711 53057832
Neutropenic infection 41.41 9.96 40 273483 1147 53074396
Full blood count increased 40.98 9.96 36 273487 911 53074632
Corneal disorder 40.79 9.96 48 273475 1733 53073810
Bronchopulmonary aspergillosis 40.73 9.96 117 273406 8548 53066995
Brain abscess 40.67 9.96 50 273473 1891 53073652
Bone lesion 40.61 9.96 90 273433 5596 53069947
Squamous cell carcinoma of skin 40.23 9.96 87 273436 5320 53070223
Product use issue 40.14 9.96 490 273033 139094 52936449
Bone erosion 40.00 9.96 5 273518 11147 53064396
Aspergillus infection 39.98 9.96 106 273417 7390 53068153
Respiratory failure 39.98 9.96 731 272792 99781 52975762
Bursitis 39.80 9.96 34 273489 22458 53053085
Tenosynovitis 39.47 9.96 3 273520 9936 53065607
Strongyloidiasis 39.45 9.96 36 273487 959 53074584
Treatment noncompliance 39.34 9.96 68 273455 32967 53042576
Diffuse large B-cell lymphoma refractory 38.94 9.96 37 273486 1039 53074504
Body height decreased 38.58 9.96 125 273398 9754 53065789
Primary amyloidosis 38.55 9.96 13 273510 36 53075507
Intentional product use issue 38.49 9.96 216 273307 72278 53003265
Blood pressure diastolic decreased 38.44 9.96 19 273504 16784 53058759
Peripheral motor neuropathy 38.31 9.96 44 273479 1547 53073996
Joint stiffness 38.23 9.96 60 273463 30223 53045320
Adrenogenital syndrome 37.80 9.96 13 273510 39 53075504
Cardiotoxicity 37.71 9.96 102 273421 7197 53068346
Infective pulmonary exacerbation of cystic fibrosis 37.67 9.96 6 273517 11150 53064393
Underdose 37.52 9.96 33 273490 21489 53054054
Nephrolithiasis 37.39 9.96 83 273440 36664 53038879
Device breakage 37.27 9.96 5 273518 10562 53064981
Feeling hot 36.86 9.96 350 273173 41194 53034349
Tooth disorder 36.74 9.96 239 273284 25073 53050470
Hypercalcaemia 36.64 9.96 232 273291 24116 53051427
Product storage error 36.40 9.96 11 273512 13119 53062424
Device malfunction 36.37 9.96 18 273505 15890 53059653
Myalgia 36.37 9.96 474 273049 133017 52942526
Medication error 36.29 9.96 83 273440 36282 53039261
Embolism 35.94 9.96 102 273421 7401 53068142
Venous thrombosis 35.40 9.96 79 273444 4935 53070608
Blood pressure increased 35.33 9.96 507 273016 139972 52935571
Intraocular pressure increased 35.32 9.96 92 273431 6346 53069197
Dyspnoea 35.28 9.96 3475 270048 582757 52492786
Product prescribing error 34.79 9.96 40 273483 22991 53052552
Nasal congestion 34.51 9.96 148 273375 53139 53022404
Keratitis fungal 34.39 9.96 16 273507 124 53075419
Crying 34.36 9.96 38 273485 22224 53053319
Seasonal allergy 34.02 9.96 162 273361 15123 53060420
Neoplasm progression 33.85 9.96 266 273257 29653 53045890
Corneal opacity 33.81 9.96 29 273494 710 53074833
Blood pressure diastolic abnormal 33.73 9.96 3 273520 8742 53066801
Contusion 33.65 9.96 384 273139 110348 52965195
Neuroleptic malignant syndrome 33.50 9.96 10 273513 12023 53063520
Type 2 diabetes mellitus 33.49 9.96 70 273453 31600 53043943
Mucormycosis 33.49 9.96 53 273470 2547 53072996
Salmonella sepsis 33.44 9.96 19 273504 232 53075311
Refractory cytopenia with multilineage dysplasia 33.33 9.96 16 273507 134 53075409
Intestinal perforation 33.31 9.96 131 273392 11249 53064294
Wheezing 33.31 9.96 197 273326 65078 53010465
Hypocalcaemia 33.28 9.96 261 273262 29076 53046467
Rhinovirus infection 33.23 9.96 66 273457 3799 53071744
Pseudomonal sepsis 33.15 9.96 48 273475 2131 53073412
White blood cell count abnormal 32.99 9.96 80 273443 5278 53070265
Chorioretinopathy 32.87 9.96 31 273492 862 53074681
Immune effector cell-associated neurotoxicity syndrome 32.72 9.96 34 273489 1066 53074477
Acute interstitial pneumonitis 32.02 9.96 28 273495 704 53074839
Radiation skin injury 31.75 9.96 31 273492 901 53074642
Body dysmorphic disorder 31.74 9.96 18 273505 219 53075324
Brain stem glioma 31.70 9.96 16 273507 151 53075392
Hordeolum 31.62 9.96 50 273473 2401 53073142
Cholecystectomy 31.57 9.96 6 273517 9809 53065734
Prescribed underdose 31.16 9.96 21 273502 15646 53059897
Coombs indirect test positive 31.05 9.96 11 273512 37 53075506
Lupus-like syndrome 31.01 9.96 5 273518 9207 53066336
Hypercholesterolaemia 30.87 9.96 13 273510 12613 53062930
Paraproteinaemia 30.57 9.96 16 273507 164 53075379
Inflammation 30.46 9.96 170 273353 56966 53018577
Stomatitis 30.45 9.96 688 272835 97470 52978073
Pneumonia cytomegaloviral 30.39 9.96 46 273477 2126 53073417
Human bocavirus infection 30.38 9.96 20 273503 323 53075220
Depressed mood 30.33 9.96 93 273430 36871 53038672
Pneumonia fungal 30.27 9.96 71 273452 4585 53070958
Light chain analysis abnormal 30.14 9.96 15 273508 137 53075406
Parkinsonism 30.09 9.96 5 273518 9008 53066535
Respiratory tract infection 30.02 9.96 281 273242 32943 53042600
Glioblastoma 29.98 9.96 29 273494 833 53074710
Hyperbilirubinaemia 29.68 9.96 124 273399 10945 53064598
Fear 29.64 9.96 25 273498 16616 53058927
Therapeutic response unexpected 29.48 9.96 27 273496 17243 53058300
Blood culture positive 29.45 9.96 70 273453 4559 53070984
Jugular vein thrombosis 29.42 9.96 53 273470 2833 53072710
Parainfluenzae virus infection 29.42 9.96 44 273479 2012 53073531
Spinal cord compression 29.37 9.96 63 273460 3831 53071712
Blood lactate dehydrogenase abnormal 29.25 9.96 18 273505 257 53075286
Joint effusion 29.20 9.96 16 273507 13336 53062207
Foot fracture 29.20 9.96 39 273484 21000 53054543
Vomiting 29.16 9.96 2942 270581 494197 52581346
Gastrointestinal fungal infection 29.07 9.96 18 273505 260 53075283
Atrial fibrillation 29.04 9.96 764 272759 110888 52964655
Cholelithiasis 28.90 9.96 110 273413 40854 53034689
Perineal necrosis 28.79 9.96 14 273509 121 53075422
Heart block congenital 28.72 9.96 8 273515 8 53075535
Labelled drug-drug interaction medication error 28.68 9.96 10 273513 10889 53064654
Accidental overdose 28.62 9.96 41 273482 21438 53054105
Glycosylated haemoglobin increased 28.50 9.96 12 273511 11643 53063900
Alopecia areata 28.33 9.96 37 273486 1488 53074055
Poor venous access 28.30 9.96 8 273515 9967 53065576
Mitochondrial DNA mutation 28.16 9.96 17 273506 234 53075309
Eosinophilia 28.16 9.96 41 273482 21294 53054249
Pneumonia pneumococcal 28.12 9.96 42 273481 1918 53073625
Renal failure 28.11 9.96 801 272722 117651 52957892
Skin discolouration 28.07 9.96 290 273233 34902 53040641
Disseminated intravascular coagulation 27.90 9.96 185 273338 19534 53056009
Gastrointestinal perforation 27.75 9.96 57 273466 3362 53072181
Propofol infusion syndrome 27.64 9.96 27 273496 785 53074758
Hiatus hernia 27.61 9.96 36 273487 19584 53055959
Hypopyon 27.58 9.96 29 273494 922 53074621
Heavy menstrual bleeding 27.55 9.96 29 273494 17347 53058196
Ocular hypertension 27.47 9.96 28 273495 858 53074685
Panic attack 27.45 9.96 42 273481 21376 53054167
Perineal infection 27.39 9.96 14 273509 136 53075407
Gastrooesophageal reflux disease 27.38 9.96 281 273242 82382 52993161
Corneal perforation 27.32 9.96 22 273501 492 53075051
Grip strength decreased 27.31 9.96 13 273510 11736 53063807
Hyperaemia 27.31 9.96 45 273478 2238 53073305
Red blood cell count decreased 27.29 9.96 293 273230 35610 53039933
Adrenal insufficiency 27.29 9.96 149 273374 14680 53060863
Clostridium difficile infection 26.77 9.96 239 273284 27654 53047889
Pneumatosis intestinalis 26.50 9.96 44 273479 2202 53073341
Musculoskeletal pain 26.42 9.96 252 273271 74948 53000595
Haemoglobin abnormal 26.41 9.96 67 273456 4547 53070996
Performance status decreased 26.31 9.96 56 273467 3387 53072156
Urticaria 26.13 9.96 515 273008 135370 52940173
Pleural effusion 25.97 9.96 616 272907 87963 52987580
Ovarian cyst 25.92 9.96 24 273499 15245 53060298
Oral candidiasis 25.88 9.96 175 273348 18598 53056945
Tardive dyskinesia 25.81 9.96 5 273518 8065 53067478
Fusarium infection 25.73 9.96 23 273500 596 53074947
Crossmatch incompatible 25.46 9.96 9 273514 30 53075513
Hyperkalaemia 24.98 9.96 169 273354 54087 53021456
Neoplasm recurrence 24.93 9.96 45 273478 2409 53073134
Vitreous haemorrhage 24.69 9.96 39 273484 1871 53073672
Pseudocellulitis 24.59 9.96 8 273515 19 53075524
Platelet count abnormal 24.58 9.96 50 273473 2928 53072615
Prescribed overdose 24.46 9.96 21 273502 13838 53061705
Dacryostenosis acquired 24.45 9.96 22 273501 575 53074968
Hepatic cirrhosis 24.41 9.96 34 273489 17988 53057555
Product dispensing error 24.31 9.96 11 273512 10229 53065314
Eczema 24.29 9.96 55 273468 24127 53051416
Hypothyroidism 24.17 9.96 99 273424 36008 53039535
Cardiopulmonary failure 24.17 9.96 57 273466 3694 53071849
Extrapyramidal disorder 24.16 9.96 17 273506 12385 53063158
Ileus 24.07 9.96 145 273378 14810 53060733
Hysterectomy 24.04 9.96 7 273516 8554 53066989
Mesenteric abscess 23.89 9.96 11 273512 83 53075460
Pre-existing condition improved 23.88 9.96 6 273517 8083 53067460
Blood pressure systolic abnormal 23.75 9.96 4 273519 7135 53068408
Vasogenic cerebral oedema 23.63 9.96 21 273502 540 53075003
Road traffic accident 23.61 9.96 61 273462 25570 53049973
Drug level increased 23.44 9.96 43 273480 20378 53055165
Osteonecrosis of jaw 23.44 9.96 286 273237 35860 53039683
Haematoma 23.16 9.96 92 273431 33752 53041791
Enthesopathy 23.16 9.96 3 273520 6508 53069035
Hypogammaglobulinaemia 23.13 9.96 76 273447 5974 53069569
Blood immunoglobulin G increased 23.06 9.96 32 273491 1365 53074178
Disease recurrence 23.02 9.96 185 273338 20761 53054782
Computerised tomogram thorax abnormal 23.01 9.96 32 273491 1368 53074175
Intermenstrual bleeding 22.85 9.96 8 273515 8690 53066853
Large intestinal ulcer perforation 22.72 9.96 10 273513 67 53075476
Superficial spreading melanoma stage unspecified 22.68 9.96 12 273511 126 53075417
Respiratory distress 22.52 9.96 269 273254 33558 53041985
Spinal fracture 22.33 9.96 153 273370 16332 53059211
Stridor 22.30 9.96 52 273471 3345 53072198
Ulcer 22.29 9.96 45 273478 20574 53054969
Hypoaesthesia 22.23 9.96 863 272660 132132 52943411
Bacterial sepsis 22.13 9.96 57 273466 3905 53071638
Bipolar disorder 22.12 9.96 6 273517 7680 53067863
Epistaxis 22.06 9.96 484 273039 68226 53007317
B precursor type acute leukaemia 22.04 9.96 14 273509 212 53075331
Electrocardiogram QT prolonged 22.01 9.96 184 273339 56219 53019324
Tremor 22.00 9.96 820 272703 124916 52950627
Post procedural infection 21.99 9.96 7 273516 8074 53067469
Central nervous system leukaemia 21.96 9.96 11 273512 102 53075441
Protein urine 21.96 9.96 22 273501 660 53074883
Recall phenomenon 21.89 9.96 21 273502 597 53074946
Antinuclear antibody positive 21.87 9.96 4 273519 6721 53068822
Hallucination, auditory 21.82 9.96 17 273506 11756 53063787
Leukoencephalopathy 21.79 9.96 59 273464 4165 53071378
Cryptococcosis 21.51 9.96 26 273497 966 53074577
Depressed level of consciousness 21.49 9.96 177 273346 54251 53021292
Scar 21.48 9.96 20 273503 12673 53062870
Candida infection 21.47 9.96 211 273312 25062 53050481
Phaeochromocytoma crisis 21.44 9.96 14 273509 223 53075320
Electrolyte imbalance 21.42 9.96 168 273355 18716 53056827
Swelling face 21.42 9.96 412 273111 56756 53018787
Klebsiella bacteraemia 21.41 9.96 30 273493 1292 53074251
Complication associated with device 21.40 9.96 31 273492 16134 53059409
Pupillary deformity 21.39 9.96 5 273518 0 53075543
Vascular pain 21.35 9.96 22 273501 683 53074860
Nasal abscess 21.30 9.96 12 273511 144 53075399
Hallucination 21.30 9.96 175 273348 53663 53021880
Philadelphia chromosome positive 21.21 9.96 16 273507 324 53075219
Spinal osteoarthritis 21.13 9.96 28 273495 15129 53060414
Escherichia test positive 21.11 9.96 39 273484 2126 53073417
Pseudomonas test positive 21.04 9.96 23 273500 765 53074778
Malignant neoplasm of unknown primary site 20.93 9.96 15 273508 280 53075263
Pneumonia viral 20.92 9.96 82 273441 7030 53068513
Nocardiosis 20.91 9.96 37 273486 1950 53073593
Panniculitis 20.85 9.96 7 273516 7807 53067736
Clostridium bacteraemia 20.81 9.96 13 273510 191 53075352
Emotional distress 20.77 9.96 90 273433 32227 53043316
Neutropenic colitis 20.77 9.96 43 273480 2550 53072993
Amenorrhoea 20.74 9.96 11 273512 9338 53066205
Procedural pain 20.71 9.96 27 273496 14690 53060853
Escherichia sepsis 20.71 9.96 61 273462 4520 53071023
Oral disorder 20.70 9.96 92 273431 8343 53067200
Spinal operation 20.63 9.96 4 273519 6447 53069096
Bone density decreased 20.48 9.96 16 273507 11048 53064495
Haematemesis 20.41 9.96 85 273438 30772 53044771
Retinal detachment 20.40 9.96 69 273454 5506 53070037
Cytomegalovirus chorioretinitis 20.40 9.96 33 273490 1616 53073927
Polyp 20.38 9.96 3 273520 5911 53069632
Intervertebral disc degeneration 20.36 9.96 26 273497 14272 53061271
Eye infection 20.27 9.96 102 273421 9736 53065807
Antithrombin III decreased 20.26 9.96 15 273508 295 53075248
Stem cell transplant 20.25 9.96 35 273488 1810 53073733
Lung infiltration 20.22 9.96 137 273386 14570 53060973
Mantle cell lymphoma recurrent 20.19 9.96 11 273512 123 53075420
Differentiation syndrome 20.15 9.96 26 273497 1033 53074510
Mucocutaneous ulceration 20.08 9.96 12 273511 162 53075381
Abnormal dreams 20.04 9.96 15 273508 10586 53064957
Rheumatic fever 20.02 9.96 21 273502 12583 53062960
Crohn's disease 19.94 9.96 5 273518 6745 53068798
Nasopharyngitis 19.87 9.96 795 272728 191500 52884043
Product packaging confusion 19.83 9.96 12 273511 166 53075377
Nightmare 19.83 9.96 38 273485 17713 53057830
Pulmonary hypertension 19.80 9.96 111 273412 37159 53038384
Sternal fracture 19.79 9.96 35 273488 1844 53073699
Cholecystitis chronic 19.74 9.96 15 273508 10503 53065040
Gastroenteritis norovirus 19.70 9.96 33 273490 1664 53073879
Enterocolitis 19.69 9.96 80 273443 6972 53068571
Iridocyclitis 19.66 9.96 38 273485 2144 53073399
Enterococcal bacteraemia 19.65 9.96 29 273494 1310 53074233
Hypertransaminasaemia 19.63 9.96 55 273468 3961 53071582
Pulmonary fibrosis 19.60 9.96 61 273462 24074 53051469
Coronary artery occlusion 19.52 9.96 9 273514 8278 53067265
Exostosis 19.34 9.96 18 273505 11406 53064137
Blood magnesium decreased 19.31 9.96 115 273408 11699 53063844
Hair texture abnormal 19.28 9.96 54 273469 3888 53071655
Device failure 19.21 9.96 4 273519 6131 53069412
Premature baby 19.17 9.96 170 273353 19631 53055912
Joint dislocation 19.13 9.96 21 273502 12324 53063219
Malaise 19.12 9.96 1576 271947 356041 52719502
Anhedonia 19.10 9.96 16 273507 10671 53064872
Peripheral sensorimotor neuropathy 19.07 9.96 29 273494 1346 53074197
Virilism 19.02 9.96 7 273516 27 53075516
Device leakage 18.96 9.96 4 273519 6076 53069467
Blood immunoglobulin A increased 18.96 9.96 16 273507 383 53075160
Femur fracture 18.87 9.96 122 273401 39463 53036080
Incorrect product administration duration 18.87 9.96 16 273507 10608 53064935
Swollen joint count increased 18.86 9.96 18 273505 11272 53064271
Pulmonary haemorrhage 18.85 9.96 78 273445 6855 53068688
Vitamin D deficiency 18.80 9.96 21 273502 12227 53063316
Varicella zoster virus infection 18.79 9.96 41 273482 2522 53073021
Atrial septal defect 18.79 9.96 6 273517 6908 53068635
Vitritis 18.77 9.96 24 273499 945 53074598
Lactose intolerance 18.73 9.96 43 273480 2738 53072805
Compression fracture 18.64 9.96 74 273449 6382 53069161
Alpha haemolytic streptococcal infection 18.62 9.96 23 273500 874 53074669
Shock 18.60 9.96 191 273332 22948 53052595
Hypotony of eye 18.50 9.96 11 273512 147 53075396
Product adhesion issue 18.46 9.96 3 273520 5494 53070049
Angina pectoris 18.46 9.96 80 273443 28645 53046898
Aggression 18.41 9.96 60 273463 23343 53052200
Diffuse large B-cell lymphoma 18.38 9.96 75 273448 6550 53068993
Cerebral aspergillosis 18.38 9.96 16 273507 400 53075143
Corneal thinning 18.34 9.96 10 273513 112 53075431
Hypothermia 18.33 9.96 24 273499 13032 53062511
Pneumonia aspiration 18.31 9.96 102 273421 34199 53041344
Respiratory arrest 18.31 9.96 99 273424 33441 53042102
Listeriosis 18.26 9.96 29 273494 1398 53074145
Venous thrombosis limb 18.18 9.96 44 273479 2899 53072644
Spinal stenosis 18.18 9.96 28 273495 14213 53061330
Iris adhesions 18.17 9.96 15 273508 348 53075195
Sedation complication 18.14 9.96 7 273516 7159 53068384
Cytomegalovirus colitis 18.10 9.96 35 273488 1975 53073568
Vein discolouration 18.06 9.96 12 273511 197 53075346
Necrotising retinitis 18.05 9.96 14 273509 296 53075247
Catabolic state 17.76 9.96 8 273515 57 53075486
Iris atrophy 17.76 9.96 8 273515 57 53075486
Metastases to meninges 17.76 9.96 36 273487 2103 53073440
Food allergy 17.75 9.96 10 273513 8208 53067335
Menstruation irregular 17.72 9.96 7 273516 7059 53068484
Eosinophil count increased 17.67 9.96 14 273509 9598 53065945
Adenocarcinoma of colon 17.60 9.96 38 273485 2321 53073222
Subclavian vein thrombosis 17.59 9.96 34 273489 1918 53073625
Movement disorder 17.56 9.96 44 273479 18637 53056906
Ulcerative keratitis 17.54 9.96 39 273484 2430 53073113
Refractory anaemia with an excess of blasts 17.51 9.96 16 273507 427 53075116
Respiratory depression 17.51 9.96 24 273499 12782 53062761
Miosis 17.46 9.96 7 273516 6995 53068548
Glioblastoma multiforme 17.45 9.96 22 273501 854 53074689
Corneal infiltrates 17.41 9.96 11 273512 165 53075378
Soft tissue disorder 17.41 9.96 55 273468 4235 53071308
Necrotising fasciitis 17.38 9.96 42 273481 2765 53072778
Rash 17.37 9.96 2574 270949 443617 52631926
Serotonin syndrome 17.30 9.96 73 273450 26333 53049210
Peritonitis bacterial 17.27 9.96 14 273509 9491 53066052
Hyperproteinaemia 17.22 9.96 9 273514 92 53075451
Obstructive airways disorder 17.21 9.96 40 273483 17389 53058154
Maternal exposure before pregnancy 17.21 9.96 4 273519 5682 53069861
Enlarged uvula 17.16 9.96 12 273511 215 53075328
Oropharyngeal squamous cell carcinoma 17.11 9.96 4 273519 0 53075543
Product administration error 17.08 9.96 55 273468 21476 53054067
Leukaemia recurrent 16.90 9.96 28 273495 1399 53074144
Chronic myelomonocytic leukaemia 16.87 9.96 14 273509 327 53075216
Loss of consciousness 16.84 9.96 451 273072 113761 52961782
Tendonitis 16.82 9.96 39 273484 16967 53058576
Palmar erythema 16.78 9.96 30 273493 1594 53073949
Chemotherapy 16.68 9.96 28 273495 1414 53074129
Breast cancer female 16.64 9.96 7 273516 6797 53068746
Pseudomyopia 16.57 9.96 8 273515 68 53075475
Tooth erosion 16.53 9.96 16 273507 460 53075083
Drug level decreased 16.52 9.96 7 273516 6767 53068776
Autonomic neuropathy 16.51 9.96 23 273500 985 53074558
Tuberculoma of central nervous system 16.45 9.96 14 273509 339 53075204
Target skin lesion 16.42 9.96 9 273514 102 53075441
Oral pain 16.39 9.96 210 273313 26627 53048916
Babesiosis 16.38 9.96 12 273511 232 53075311
Neck pain 16.37 9.96 213 273310 59803 53015740
Intraocular pressure decreased 16.30 9.96 10 273513 142 53075401
Refractory anaemia with ringed sideroblasts 16.29 9.96 5 273518 9 53075534
Fungal abscess central nervous system 16.29 9.96 5 273518 9 53075534
Dyskinesia 16.27 9.96 96 273427 31737 53043806
Colitis microscopic 16.26 9.96 8 273515 7086 53068457
Amnesia 16.23 9.96 151 273372 45137 53030406
Infection reactivation 16.23 9.96 23 273500 1001 53074542
Pulse waveform abnormal 16.18 9.96 8 273515 72 53075471
Fungaemia 16.16 9.96 35 273488 2142 53073401
Hypogeusia 16.14 9.96 25 273498 1179 53074364
Abortion induced 16.14 9.96 19 273504 10807 53064736
Madarosis 16.10 9.96 41 273482 2789 53072754
Ankle brachial index decreased 16.08 9.96 8 273515 73 53075470
Genital haemorrhage 16.06 9.96 8 273515 7036 53068507
Alveolitis 16.06 9.96 40 273483 2684 53072859
Enterococcal sepsis 16.03 9.96 27 273496 1367 53074176
Transplant rejection 16.03 9.96 17 273506 10134 53065409
Myelopathy 15.99 9.96 40 273483 2691 53072852
Staphylococcal sepsis 15.95 9.96 81 273442 7759 53067784
Lower respiratory tract infection 15.95 9.96 350 273173 90631 52984912
Botryomycosis 15.95 9.96 6 273517 25 53075518
Ileus paralytic 15.94 9.96 56 273467 4555 53070988
Staphylococcal bacteraemia 15.94 9.96 61 273462 5172 53070371
Nail dystrophy 15.93 9.96 19 273504 696 53074847
Transplant dysfunction 15.92 9.96 3 273520 4935 53070608
Tuberculosis 15.90 9.96 20 273503 11051 53064492
Meningitis cryptococcal 15.89 9.96 26 273497 1285 53074258
Diverticular perforation 15.86 9.96 46 273477 3379 53072164
Herpes simplex 15.83 9.96 80 273443 7649 53067894
Renal amyloidosis 15.83 9.96 10 273513 150 53075393
White blood cell count increased 15.81 9.96 156 273367 46089 53029454
Chronic kidney disease 15.81 9.96 144 273379 43226 53032317
Lymphoedema 15.80 9.96 94 273429 9559 53065984
Bone marrow infiltration 15.76 9.96 16 273507 488 53075055
Gastrointestinal toxicity 15.75 9.96 57 273466 4705 53070838
Metapneumovirus infection 15.73 9.96 20 273503 783 53074760
Pain in jaw 15.72 9.96 133 273390 40536 53035007
Acute myeloid leukaemia 15.69 9.96 144 273379 16788 53058755
Plasmablastic lymphoma 15.66 9.96 12 273511 249 53075294
Enterobacter infection 15.65 9.96 33 273490 1983 53073560
Lymphorrhoea 15.64 9.96 7 273516 49 53075494
Carotid intima-media thickness increased 15.63 9.96 8 273515 78 53075465
Skin exfoliation 15.61 9.96 266 273257 35817 53039726
Lip swelling 15.57 9.96 79 273444 27122 53048421
Therapy non-responder 15.45 9.96 345 273178 48775 53026768
Scoliosis 15.41 9.96 8 273515 6874 53068669
Pre-eclampsia 15.39 9.96 13 273510 8634 53066909
Caesarean section 15.36 9.96 42 273481 17278 53058265
Salmonella bacteraemia 15.35 9.96 9 273514 117 53075426
Birdshot chorioretinopathy 15.28 9.96 8 273515 82 53075461
Therapeutic response decreased 15.22 9.96 163 273360 47406 53028137
Chalazion 15.20 9.96 13 273510 317 53075226
Adenocarcinoma pancreas 15.20 9.96 24 273499 1151 53074392
Akathisia 15.11 9.96 13 273510 8558 53066985
POEMS syndrome 15.07 9.96 6 273517 30 53075513
Mood swings 15.06 9.96 43 273480 17443 53058100
Adjusted calcium increased 15.05 9.96 5 273518 13 53075530
Myopathy 14.98 9.96 93 273430 9599 53065944
Aplastic anaemia 14.90 9.96 83 273440 8238 53067305
Oesophageal squamous cell carcinoma 14.84 9.96 9 273514 125 53075418
Arachnoiditis 14.80 9.96 13 273510 329 53075214
Diverticulitis intestinal perforated 14.79 9.96 5 273518 14 53075529
Plasma cell myeloma refractory 14.79 9.96 5 273518 14 53075529
Streptococcal bacteraemia 14.78 9.96 28 273495 1556 53073987
Pruritus 14.78 9.96 1301 272222 292531 52783012
Failure to thrive 14.77 9.96 73 273450 6919 53068624
Ascites 14.76 9.96 286 273237 39449 53036094
Punctate keratitis 14.75 9.96 17 273506 600 53074943
Tonsillar disorder 14.67 9.96 22 273501 1008 53074535
Pulmonary sepsis 14.66 9.96 27 273496 1468 53074075
Polychromasia 14.64 9.96 8 273515 90 53075453
Retinal pigment epitheliopathy 14.62 9.96 11 273512 222 53075321
Visual acuity reduced 14.61 9.96 178 273345 22307 53053236
Application site erythema 14.60 9.96 4 273519 5087 53070456
Acne 14.56 9.96 59 273464 21527 53054016
Spinal compression fracture 14.55 9.96 120 273403 13570 53061973
Musculoskeletal chest pain 14.55 9.96 160 273363 19562 53055981
Device use error 14.55 9.96 5 273518 5494 53070049
Hypergeusia 14.54 9.96 5 273518 15 53075528
Breast cancer metastatic 14.53 9.96 131 273392 15197 53060346
Meniscus injury 14.52 9.96 8 273515 6647 53068896
Blood creatine phosphokinase increased 14.51 9.96 88 273435 28897 53046646
Infusion site streaking 14.50 9.96 14 273509 401 53075142
Renal replacement therapy 14.46 9.96 6 273517 34 53075509
Haematochezia 14.43 9.96 143 273380 42215 53033328
Uterine leiomyoma 14.43 9.96 14 273509 8698 53066845
Intentional dose omission 14.40 9.96 4 273519 5041 53070502
Ocular hyperaemia 14.38 9.96 173 273350 21618 53053925
Cataract traumatic 14.36 9.96 4 273519 4 53075539
Palatal ulcer 14.35 9.96 7 273516 61 53075482
Rotator cuff syndrome 14.35 9.96 26 273497 12379 53063164
Post procedural complication 14.34 9.96 41 273482 16625 53058918
Urosepsis 14.27 9.96 139 273384 16471 53059072
Infusion site swelling 14.27 9.96 9 273514 6945 53068598
Osteomyelitis bacterial 14.26 9.96 10 273513 180 53075363
Mucosal infection 14.24 9.96 9 273514 135 53075408
Lentigo maligna 14.17 9.96 10 273513 182 53075361
Superior vena cava occlusion 14.15 9.96 7 273516 63 53075480
Sputum discoloured 14.09 9.96 33 273490 14306 53061237
Encephalitis 14.07 9.96 79 273444 7865 53067678
Immune-mediated encephalitis 14.06 9.96 7 273516 64 53075479
Gastric perforation 14.00 9.96 27 273496 1521 53074022
Hemiparesis 13.95 9.96 170 273353 21305 53054238
Skin sensitisation 13.94 9.96 19 273504 797 53074746
Electrocardiogram QRS complex prolonged 13.90 9.96 6 273517 5736 53069807
Rectal adenocarcinoma 13.89 9.96 17 273506 640 53074903
Therapeutic response delayed 13.85 9.96 16 273507 566 53074977
Mental disorder 13.84 9.96 71 273452 24305 53051238
Injection site irritation 13.83 9.96 3 273520 4469 53071074
Cerebrovascular accident 13.81 9.96 422 273101 104752 52970791
Gastritis 13.78 9.96 119 273404 36115 53039428
Heart rate increased 13.77 9.96 319 273204 81996 52993547
Papule 13.75 9.96 54 273469 4633 53070910
Disability 13.75 9.96 27 273496 12471 53063072
Genital rash 13.75 9.96 15 273508 498 53075045
Vision blurred 13.72 9.96 553 272970 85051 52990492
Cancer pain 13.60 9.96 39 273484 2847 53072696
Monoclonal immunoglobulin increased 13.58 9.96 8 273515 105 53075438
Therapy cessation 13.55 9.96 86 273437 27939 53047604
Respiratory depth decreased 13.53 9.96 6 273517 41 53075502
Sense of oppression 13.50 9.96 22 273501 1084 53074459
Disturbance in attention 13.49 9.96 112 273411 34271 53041272
Bradyphrenia 13.49 9.96 9 273514 6741 53068802
Epstein Barr virus positive mucocutaneous ulcer 13.49 9.96 12 273511 309 53075234
Aqueous humour leakage 13.48 9.96 4 273519 6 53075537
Haemophilus bacteraemia 13.48 9.96 4 273519 6 53075537
Amoebic brain abscess 13.48 9.96 4 273519 6 53075537
Plasma cell myeloma in remission 13.48 9.96 4 273519 6 53075537
Renal disorder 13.41 9.96 217 273306 28922 53046621
Blood fibrinogen decreased 13.37 9.96 18 273505 746 53074797
Cerebellar haemangioma 13.35 9.96 7 273516 72 53075471
Drug tolerance 13.34 9.96 3 273520 4360 53071183
Blood gases abnormal 13.34 9.96 17 273506 667 53074876
Sinus polyp 13.33 9.96 12 273511 314 53075229
Thiopurine methyltransferase decreased 13.33 9.96 12 273511 314 53075229
Nail infection 13.29 9.96 32 273491 2102 53073441
Eye discharge 13.27 9.96 58 273465 5222 53070321
Intraductal proliferative breast lesion 13.23 9.96 38 273485 2776 53072767
Hyperamylasaemia 13.20 9.96 13 273510 382 53075161
Muscle rigidity 13.19 9.96 22 273501 10819 53064724
Hypothalamic pituitary adrenal axis suppression 13.18 9.96 9 273514 155 53075388
Vascular compression 13.14 9.96 8 273515 112 53075431
Gastrointestinal disorder 13.11 9.96 356 273167 89648 52985895
Lipogranuloma 13.10 9.96 4 273519 7 53075536
Foetal exposure during delivery 13.06 9.96 6 273517 45 53075498
JC virus infection 13.03 9.96 29 273494 1808 53073735
Emphysematous cystitis 13.03 9.96 9 273514 158 53075385
Asphyxia 13.01 9.96 7 273516 5894 53069649
Choroiditis 12.98 9.96 9 273514 159 53075384
General physical health deterioration 12.93 9.96 897 272626 146045 52929498
Deformity 12.92 9.96 13 273510 7941 53067602
Mantle cell lymphoma 12.91 9.96 16 273507 610 53074933
Otitis media acute 12.90 9.96 20 273503 944 53074599
Postictal state 12.88 9.96 21 273502 1035 53074508
Radiotherapy to brain 12.84 9.96 3 273520 0 53075543
Cleft palate repair 12.84 9.96 3 273520 0 53075543
Acute respiratory distress syndrome 12.77 9.96 179 273344 23153 53052390
Major depression 12.77 9.96 12 273511 7570 53067973
Bone infarction 12.77 9.96 11 273512 271 53075272
Urethral cancer 12.76 9.96 4 273519 8 53075535
Renal-limited thrombotic microangiopathy 12.76 9.96 4 273519 8 53075535
Joint injury 12.75 9.96 64 273459 22036 53053507
Peritonitis viral 12.73 9.96 6 273517 48 53075495
Blood cholesterol increased 12.70 9.96 193 273330 52796 53022747
Sialoadenitis 12.65 9.96 24 273499 1335 53074208
Immune system disorder 12.62 9.96 81 273442 8457 53067086
Low density lipoprotein increased 12.62 9.96 8 273515 6158 53069385
Chest pain 12.57 9.96 823 272700 189362 52886181
Histiocytic sarcoma 12.57 9.96 7 273516 82 53075461
Therapy interrupted 12.57 9.96 54 273469 19382 53056161
Endocarditis bacterial 12.55 9.96 16 273507 628 53074915
Eye abscess 12.55 9.96 8 273515 122 53075421
Non-small cell lung cancer metastatic 12.53 9.96 16 273507 629 53074914
Somnambulism 12.52 9.96 6 273517 5396 53070147
Enteritis 12.50 9.96 73 273450 7373 53068170
Diastolic hypotension 12.50 9.96 7 273516 83 53075460
Drug dependence 12.50 9.96 62 273461 21410 53054133
Visceral leishmaniasis 12.49 9.96 14 273509 479 53075064
Aplasia pure red cell 12.47 9.96 4 273519 4592 53070951
Adenoviral haemorrhagic cystitis 12.47 9.96 9 273514 170 53075373
Persistent corneal epithelial defect 12.45 9.96 4 273519 9 53075534
Cardio-respiratory arrest 12.43 9.96 219 273304 58539 53017004
Malignant transformation 12.42 9.96 12 273511 344 53075199
Capillary leak syndrome 12.42 9.96 30 273493 1974 53073569
Hyperpyrexia 12.41 9.96 42 273481 3352 53072191
Chills 12.41 9.96 657 272866 104191 52971352
Application site pruritus 12.40 9.96 3 273520 4146 53071397
Hypersensitivity 12.38 9.96 921 272602 209744 52865799
Hallucination, visual 12.38 9.96 52 273471 18780 53056763
Gene mutation 12.37 9.96 23 273500 1260 53074283
Angina unstable 12.37 9.96 12 273511 7456 53068087
Polyarthritis 12.35 9.96 13 273510 7776 53067767
Myeloma cast nephropathy 12.33 9.96 8 273515 126 53075417
Blood calcium abnormal 12.32 9.96 21 273502 1074 53074469
Conjunctival hyperaemia 12.29 9.96 32 273491 2207 53073336
Leukaemic lymphoma 12.28 9.96 7 273516 86 53075457
Frustration tolerance decreased 12.22 9.96 8 273515 6053 53069490
Enterocolitis infectious 12.20 9.96 26 273497 1574 53073969
Morganella infection 12.17 9.96 15 273508 569 53074974
Gastrointestinal haemorrhage 12.15 9.96 316 273207 80014 52995529
Blastic plasmacytoid dendritic cell neoplasia 12.10 9.96 5 273518 28 53075515
Hypophosphataemia 12.09 9.96 82 273441 8723 53066820
Secondary immunodeficiency 12.04 9.96 21 273502 1094 53074449
Bone debridement 12.03 9.96 12 273511 358 53075185
Hyphaema 12.03 9.96 9 273514 180 53075363
Frequent bowel movements 12.01 9.96 36 273487 14376 53061167
Apathy 11.96 9.96 15 273508 8297 53067246
Torsade de pointes 11.94 9.96 31 273492 12974 53062569
Bundle branch block left 11.93 9.96 11 273512 7002 53068541
Steroid diabetes 11.91 9.96 19 273504 919 53074624
Laryngeal inflammation 11.90 9.96 8 273515 134 53075409
Light chain analysis 11.88 9.96 4 273519 11 53075532
Uterine fistula 11.88 9.96 4 273519 11 53075532
Arteriosclerosis 11.87 9.96 21 273502 10090 53065453
Skin ulcer 11.86 9.96 123 273400 35996 53039547
Anaphylactoid reaction 11.78 9.96 44 273479 3687 53071856
Forced expiratory volume decreased 11.77 9.96 7 273516 5578 53069965
Embolism venous 11.76 9.96 38 273485 2961 53072582
Human herpesvirus 6 infection 11.74 9.96 34 273489 2496 53073047
Urinary tract infection 11.69 9.96 1403 272120 238500 52837043
Acute respiratory failure 11.61 9.96 225 273298 31033 53044510
Meningitis streptococcal 11.60 9.96 8 273515 140 53075403
Vitreous opacities 11.60 9.96 11 273512 308 53075235
Injection site discolouration 11.54 9.96 12 273511 7218 53068325
Paraparesis 11.53 9.96 31 273492 2179 53073364
Demyelination 11.53 9.96 9 273514 6218 53069325
B-cell type acute leukaemia 11.51 9.96 8 273515 142 53075401
Soft tissue infection 11.50 9.96 30 273493 2071 53073472
Adverse event 11.47 9.96 145 273378 40916 53034627
Appendiceal abscess 11.46 9.96 9 273514 194 53075349
Hernia 11.43 9.96 22 273501 10238 53065305
Macular hole 11.42 9.96 17 273506 774 53074769
Emphysema 11.40 9.96 21 273502 9938 53065605
Ear infection staphylococcal 11.39 9.96 4 273519 13 53075530
Substance-induced mood disorder 11.39 9.96 4 273519 13 53075530
Escherichia urinary tract infection 11.38 9.96 97 273426 11076 53064467
Atelectasis 11.37 9.96 154 273369 19772 53055771
Diabetes mellitus 11.37 9.96 201 273322 53698 53021845
Drug clearance decreased 11.36 9.96 21 273502 1145 53074398
Cerebral venous thrombosis 11.36 9.96 32 273491 2312 53073231
Blood potassium increased 11.27 9.96 50 273473 17791 53057752
Urinary tract infection enterococcal 11.25 9.96 34 273489 2555 53072988
Large intestine polyp 11.25 9.96 15 273508 8082 53067461
Cauda equina syndrome 11.24 9.96 17 273506 785 53074758
Foetal growth restriction 11.19 9.96 69 273454 7105 53068438
Phyllodes tumour 11.17 9.96 5 273518 35 53075508
Listeria encephalitis 11.13 9.96 10 273513 261 53075282
Arterial occlusive disease 11.12 9.96 6 273517 5043 53070500
Cholangitis infective 11.08 9.96 9 273514 204 53075339
Alopecia totalis 11.06 9.96 11 273512 327 53075216
Bronchitis chronic 11.03 9.96 4 273519 4250 53071293
Flat anterior chamber of eye 11.02 9.96 6 273517 67 53075476
Unintentional medical device removal 11.01 9.96 7 273516 5379 53070164
Blood glucose decreased 10.97 9.96 59 273464 19957 53055586
Blood stem cell transplant failure 10.95 9.96 8 273515 154 53075389
Thrombophlebitis superficial 10.94 9.96 53 273470 4982 53070561
Cyst 10.94 9.96 32 273491 12879 53062664
Pneumonia bacterial 10.94 9.96 74 273449 7866 53067677
Hair colour changes 10.93 9.96 36 273487 2833 53072710
Atypical pneumonia 10.92 9.96 44 273479 3821 53071722
Hepatitis 10.90 9.96 116 273407 33778 53041765
Catheter site bruise 10.87 9.96 11 273512 334 53075209
Intracranial tumour haemorrhage 10.86 9.96 8 273515 156 53075387
Protein total abnormal 10.84 9.96 12 273511 405 53075138
Meningitis pneumococcal 10.82 9.96 9 273514 211 53075332
Oxygen saturation 10.82 9.96 9 273514 211 53075332
Throat tightness 10.81 9.96 167 273356 22049 53053494
Pseudomonal bacteraemia 10.79 9.96 23 273500 1392 53074151
Lymphocyte count decreased 10.79 9.96 203 273320 27849 53047694
Circulatory collapse 10.77 9.96 170 273353 22544 53052999
Hypertension 10.76 9.96 1002 272521 224429 52851114
Colony stimulating factor therapy 10.74 9.96 11 273512 339 53075204
Delusion 10.74 9.96 29 273494 11980 53063563
Rash pruritic 10.72 9.96 334 273189 49676 53025867
Nasal disorder 10.72 9.96 32 273491 2389 53073154
Cerebral artery thrombosis 10.68 9.96 12 273511 412 53075131
Stenotrophomonas test positive 10.57 9.96 4 273519 17 53075526
Splinter haemorrhages 10.57 9.96 4 273519 17 53075526
Ciliary hyperaemia 10.57 9.96 4 273519 17 53075526
Cardiac failure congestive 10.56 9.96 379 273144 92378 52983165
Skin striae 10.49 9.96 20 273503 1117 53074426
Meningoencephalitis herpetic 10.47 9.96 20 273503 1118 53074425
Arteriosclerosis coronary artery 10.43 9.96 17 273506 8437 53067106
Brain neoplasm 10.40 9.96 45 273478 4033 53071510
Dysphonia 10.33 9.96 285 273238 41653 53033890
Posterior capsule rupture 10.31 9.96 3 273520 4 53075539
Ear swelling 10.30 9.96 21 273502 1232 53074311
Fungal oesophagitis 10.29 9.96 14 273509 586 53074957
Anger 10.29 9.96 31 273492 12359 53063184
Increased appetite 10.26 9.96 81 273442 9041 53066502
Choking 10.24 9.96 20 273503 9256 53066287
Injection site phlebitis 10.23 9.96 7 273516 121 53075422
Renal cyst 10.17 9.96 21 273502 9524 53066019
Pneumonia parainfluenzae viral 10.17 9.96 6 273517 79 53075464
Ketoacidosis 10.13 9.96 5 273518 4421 53071122
Aborted pregnancy 10.11 9.96 5 273518 45 53075498
Blood pressure diastolic increased 10.10 9.96 13 273510 7111 53068432
Urinary tract infection bacterial 10.05 9.96 48 273475 4486 53071057
Brain tumour operation 10.05 9.96 4 273519 20 53075523
Ureteritis 10.05 9.96 4 273519 20 53075523
Natural killer-cell lymphoblastic lymphoma 10.05 9.96 4 273519 20 53075523
Acute lymphocytic leukaemia refractory 10.04 9.96 6 273517 81 53075462
Actinomycosis 10.04 9.96 19 273504 1055 53074488
Hypophagia 10.03 9.96 219 273304 30843 53044700
Ankle fracture 10.01 9.96 47 273476 16468 53059075
Thrombotic microangiopathy 10.01 9.96 82 273441 9255 53066288
Intervertebral disc disorder 9.98 9.96 6 273517 4751 53070792
Blood thyroid stimulating hormone increased 9.97 9.96 11 273512 6441 53069102

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 5568.94 11.26 4213 257856 53401 32198056
Neuropathy peripheral 1255.87 11.26 2236 259833 74746 32176711
Neutropenia 908.20 11.26 2861 259208 139314 32112143
Pneumonia 768.65 11.26 5187 256882 350065 31901392
Thrombocytopenia 735.34 11.26 2743 259326 145556 32105901
Febrile neutropenia 660.82 11.26 2292 259777 117274 32134183
Completed suicide 613.93 11.26 32 262037 92485 32158972
Drug abuse 525.39 11.26 30 262039 80213 32171244
Plasma cell myeloma recurrent 519.78 11.26 347 261722 3530 32247927
Drug interaction 470.06 11.26 644 261425 217541 32033916
Unevaluable event 452.67 11.26 900 261169 32686 32218771
Deep vein thrombosis 401.83 11.26 1278 260791 62435 32189022
Platelet count decreased 398.09 11.26 1903 260166 112688 32138769
Full blood count decreased 341.78 11.26 543 261526 16467 32234990
Thrombosis 338.51 11.26 971 261098 44783 32206674
Overdose 336.78 11.26 140 261929 86937 32164520
Pancytopenia 335.65 11.26 1541 260528 89694 32161763
Plasmacytoma 328.56 11.26 252 261817 3241 32248216
Intentional overdose 313.81 11.26 4 262065 41597 32209860
Rheumatoid arthritis 290.41 11.26 17 262052 44527 32206930
White blood cell count decreased 286.97 11.26 1473 260596 89725 32161732
Fatigue 274.43 11.26 4152 257917 346549 31904908
Pulmonary embolism 268.61 11.26 1359 260710 82300 32169157
Disease progression 262.91 11.26 1388 260681 85474 32165983
Constipation 250.94 11.26 1811 260258 124562 32126895
Cytopenia 241.50 11.26 349 261720 9715 32241742
Off label use 234.45 11.26 3614 258455 302706 31948751
Laboratory test abnormal 231.70 11.26 490 261579 18597 32232860
Rhabdomyolysis 218.41 11.26 136 261933 67129 32184328
Psoriasis 215.72 11.26 53 262016 46070 32205387
Sepsis 207.04 11.26 2072 259997 156762 32094695
Suicide attempt 206.20 11.26 31 262038 38213 32213244
Neutropenic sepsis 201.56 11.26 365 261704 12334 32239123
Plasma cell leukaemia 199.85 11.26 113 261956 828 32250629
Tumour lysis syndrome 196.10 11.26 390 261679 14157 32237300
Suicidal ideation 187.64 11.26 39 262030 38044 32213413
Neutrophil count decreased 187.27 11.26 815 261254 46324 32205133
Blood creatine phosphokinase increased 182.49 11.26 69 262000 45407 32206050
Septic shock 172.06 11.26 1047 261022 67942 32183515
Arthralgia 166.92 11.26 624 261445 147824 32103633
Hiccups 164.20 11.26 290 261779 9605 32241852
Adverse drug reaction 162.16 11.26 518 261551 25343 32226114
Endophthalmitis 160.28 11.26 178 261891 3771 32247686
Polyneuropathy 156.62 11.26 336 261733 12879 32238578
Intentional product misuse 150.95 11.26 51 262018 36000 32215457
Depression 147.97 11.26 354 261715 96706 32154751
Injection site pain 145.12 11.26 43 262026 33015 32218442
Squamous cell carcinoma of skin 142.87 11.26 272 261797 9554 32241903
Pyrexia 135.48 11.26 3454 258615 316514 31934943
Pneumocystis jirovecii pneumonia 133.23 11.26 394 261675 18476 32232981
Drug ineffective 132.69 11.26 2235 259834 381242 31870215
Inappropriate schedule of product administration 132.43 11.26 105 261964 45720 32205737
Hospitalisation 131.98 11.26 120 261949 48851 32202606
Coronary artery disease 130.20 11.26 125 261944 49581 32201876
Mucosal inflammation 129.67 11.26 574 261495 32860 32218597
Intraocular pressure increased 129.64 11.26 192 261877 5466 32245991
Hypoglycaemia 128.72 11.26 149 261920 54233 32197224
Myelodysplastic syndrome 128.03 11.26 404 261665 19634 32231823
Death 126.66 11.26 4002 258067 378515 31872942
Wrong technique in product usage process 126.64 11.26 62 262007 34997 32216460
Venoocclusive liver disease 126.29 11.26 219 261850 7146 32244311
Strongyloidiasis 126.22 11.26 128 261941 2433 32249024
Headache 126.06 11.26 995 261074 195202 32056255
Complication of device insertion 124.41 11.26 43 262026 68 32251389
Diarrhoea 122.67 11.26 3824 258245 360978 31890479
Drug dependence 122.17 11.26 21 262048 23463 32227994
Myocardial infarction 120.27 11.26 562 261507 125114 32126343
Leukopenia 117.60 11.26 859 261210 59263 32192194
Febrile bone marrow aplasia 116.30 11.26 228 261841 8187 32243270
Anxiety 114.83 11.26 393 261676 95612 32155845
Asthma 114.03 11.26 112 261957 43953 32207504
Light chain analysis increased 113.30 11.26 85 261984 1055 32250402
Drug withdrawal syndrome 112.32 11.26 15 262054 20216 32231241
Haematotoxicity 109.10 11.26 196 261873 6580 32244877
Hallucination 107.31 11.26 161 261908 52458 32198999
Neuroleptic malignant syndrome 107.28 11.26 9 262060 17486 32233971
Aggression 105.57 11.26 97 261972 39292 32212165
Myalgia 103.02 11.26 324 261745 80906 32170551
Osteonecrosis 102.42 11.26 331 261738 16291 32235166
Serotonin syndrome 101.89 11.26 16 262053 19101 32232356
Cytomegalovirus chorioretinitis 101.23 11.26 135 261934 3477 32247980
Drug hypersensitivity 98.65 11.26 285 261784 73115 32178342
Osteonecrosis of jaw 98.28 11.26 359 261710 18807 32232650
Malignant neoplasm progression 96.30 11.26 1012 261057 77484 32173973
Condition aggravated 95.96 11.26 798 261271 154863 32096594
Tooth disorder 94.41 11.26 234 261835 9873 32241584
Therapy partial responder 94.38 11.26 154 261915 4776 32246681
Angioedema 93.01 11.26 93 261976 36196 32215261
Stress 92.24 11.26 38 262031 23744 32227713
Electrocardiogram QT prolonged 91.24 11.26 111 261958 39530 32211927
Monoclonal immunoglobulin present 91.14 11.26 69 262000 869 32250588
Acute lymphocytic leukaemia recurrent 91.02 11.26 118 261951 2954 32248503
Hypofibrinogenaemia 86.83 11.26 87 261982 1629 32249828
Bone marrow failure 86.51 11.26 478 261591 29926 32221531
Rash 84.31 11.26 2246 259823 207087 32044370
Haemophagocytic lymphohistiocytosis 84.16 11.26 241 261828 11094 32240363
Body height decreased 83.89 11.26 127 261942 3688 32247769
COVID-19 83.65 11.26 492 261577 31523 32219934
Infection 83.61 11.26 1047 261022 83668 32167789
International normalised ratio increased 83.61 11.26 168 261901 48867 32202590
Psoriatic arthropathy 82.56 11.26 21 262048 17839 32233618
Peripheral sensory neuropathy 82.26 11.26 170 261899 6344 32245113
Diffuse large B-cell lymphoma recurrent 81.28 11.26 103 261966 2519 32248938
Hyperkalaemia 81.04 11.26 289 261780 69461 32181996
Anaemia 80.73 11.26 2366 259703 221258 32030199
Posterior reversible encephalopathy syndrome 80.43 11.26 213 261856 9363 32242094
Corneal oedema 80.41 11.26 77 261992 1361 32250096
Sedation 79.67 11.26 25 262044 18501 32232956
Incorrect dose administered 79.65 11.26 99 261970 34929 32216528
Bone lesion 79.44 11.26 108 261961 2835 32248622
Lactic acidosis 79.22 11.26 92 261977 33444 32218013
Product prescribing error 78.94 11.26 30 262039 19687 32231770
Myelosuppression 78.83 11.26 240 261829 11436 32240021
Hypercalcaemia 77.89 11.26 268 261801 13626 32237831
COVID-19 pneumonia 77.39 11.26 198 261871 8522 32242935
Acute lymphocytic leukaemia 77.20 11.26 117 261952 3401 32248056
Colitis ulcerative 77.01 11.26 21 262048 17030 32234427
Respiratory arrest 76.50 11.26 72 261997 28836 32222621
Contraindicated product administered 76.41 11.26 29 262040 19047 32232410
Cataract 76.17 11.26 391 261678 23792 32227665
Intentional self-injury 75.53 11.26 11 262058 13889 32237568
Cytokine release syndrome 74.07 11.26 259 261810 13276 32238181
Product use in unapproved indication 73.73 11.26 1048 261021 86156 32165301
Ageusia 73.71 11.26 208 261861 9494 32241963
Stomatitis 73.66 11.26 566 261503 39663 32211794
Abnormal behaviour 72.32 11.26 64 262005 26402 32225055
Somnolence 71.94 11.26 515 261554 103282 32148175
Dyskinesia 70.84 11.26 52 262017 23551 32227906
Treatment noncompliance 70.53 11.26 69 262000 27133 32224324
Amyloidosis 70.22 11.26 89 261980 2177 32249280
Coma 70.10 11.26 149 261920 42463 32208994
Blood pressure increased 70.01 11.26 365 261704 78989 32172468
Peritonitis bacterial 70.00 11.26 9 262060 12487 32238970
Multiple sclerosis relapse 69.72 11.26 7 262062 11774 32239683
Diffuse large B-cell lymphoma refractory 69.68 11.26 59 262010 881 32250576
Bacteraemia 69.31 11.26 304 261765 17329 32234128
Injury 68.08 11.26 48 262021 22197 32229260
Product substitution issue 67.95 11.26 4 262065 10432 32241025
Poisoning 67.71 11.26 6 262063 11152 32240305
Loss of personal independence in daily activities 66.24 11.26 71 261998 26762 32224695
Product quality issue 65.04 11.26 37 262032 19196 32232261
Hyperglycaemia 62.59 11.26 526 261543 37865 32213592
Respiratory tract infection 62.52 11.26 291 261778 17014 32234443
Blood pressure fluctuation 62.21 11.26 43 262026 20092 32231365
Musculoskeletal stiffness 61.54 11.26 141 261928 39123 32212334
Hallucination, visual 60.97 11.26 31 262038 17128 32234329
Mucormycosis 60.49 11.26 138 261931 5516 32245941
Accidental overdose 60.15 11.26 41 262028 19298 32232159
Surgery 59.83 11.26 14 262055 12585 32238872
Neurotoxicity 59.37 11.26 260 261809 14810 32236647
Bone pain 59.32 11.26 322 261747 20022 32231435
Gastrointestinal haemorrhage 58.78 11.26 434 261635 86448 32165009
Lymphopenia 56.64 11.26 249 261820 14207 32237250
Erectile dysfunction 56.62 11.26 46 262023 19793 32231664
Influenza 56.27 11.26 593 261476 45421 32206036
Synovitis 55.98 11.26 10 262059 10868 32240589
Sopor 55.90 11.26 13 262056 11736 32239721
Sleep apnoea syndrome 55.75 11.26 42 262027 18772 32232685
Acute myeloid leukaemia 55.58 11.26 303 261766 18871 32232586
Infective pulmonary exacerbation of cystic fibrosis 55.28 11.26 4 262065 8775 32242682
Eosinophilia 55.22 11.26 72 261997 24886 32226571
Osteolysis 55.02 11.26 70 261999 1719 32249738
Parainfluenzae virus infection 54.54 11.26 80 261989 2257 32249200
Infusion related reaction 54.53 11.26 585 261484 45014 32206443
Bronchopulmonary aspergillosis 53.81 11.26 236 261833 13451 32238006
Muscle spasms 53.53 11.26 831 261238 69587 32181870
Melaena 53.11 11.26 126 261943 34539 32216918
Full blood count increased 52.49 11.26 48 262021 798 32250659
Hepatic cirrhosis 51.79 11.26 36 262033 16773 32234684
Respiratory depression 51.41 11.26 21 262048 13190 32238267
Ventricular tachycardia 51.31 11.26 79 261990 25477 32225980
Labelled drug-drug interaction medication error 51.19 11.26 18 262051 12395 32239062
Pain 51.12 11.26 1137 260932 186419 32065038
Fear 51.01 11.26 14 262055 11305 32240152
Spinal cord compression 50.44 11.26 102 261967 3747 32247710
Cushingoid 49.13 11.26 82 261987 2592 32248865
Metabolic acidosis 49.02 11.26 166 261903 40533 32210924
Wheezing 48.91 11.26 144 261925 36730 32214727
Chest pain 48.90 11.26 705 261364 123432 32128025
Medication error 47.84 11.26 67 262002 22468 32228989
Microsporidia infection 47.81 11.26 40 262029 587 32250870
Spinal fracture 47.78 11.26 146 261923 6970 32244487
Lower respiratory tract infection 47.31 11.26 400 261669 28843 32222614
Pneumonia influenzal 47.28 11.26 59 262010 1420 32250037
Bone disorder 46.99 11.26 142 261927 6738 32244719
Nightmare 46.46 11.26 24 262045 13142 32238315
Emotional distress 46.29 11.26 38 262031 16268 32235189
Agitation 46.23 11.26 271 261798 56965 32194492
Foetal exposure during pregnancy 46.06 11.26 174 261895 41127 32210330
Injection site erythema 45.75 11.26 31 262038 14637 32236820
Hepatitis C 45.72 11.26 26 262043 13492 32237965
Pathological fracture 45.66 11.26 104 261965 4152 32247305
Loss of consciousness 45.61 11.26 436 261633 82271 32169186
Neoplasm progression 45.60 11.26 293 261776 19365 32232092
Depressed level of consciousness 44.96 11.26 173 261896 40674 32210783
Torsade de pointes 44.96 11.26 4 262065 7411 32244046
Muscle rigidity 44.81 11.26 17 262052 11169 32240288
Asthenia 44.49 11.26 2326 259743 233618 32017839
Ulcerative keratitis 43.96 11.26 58 262011 1478 32249979
Pulmonary thrombosis 43.91 11.26 139 261930 6765 32244692
Gynaecomastia 43.49 11.26 9 262060 8810 32242647
Corneal decompensation 43.29 11.26 12 262057 3 32251454
H1N1 influenza 43.26 11.26 46 262023 926 32250531
Acute kidney injury 43.16 11.26 1930 260139 291538 31959919
Large intestine perforation 43.13 11.26 154 261915 7976 32243481
Pemphigoid 42.88 11.26 8 262061 8428 32243029
Palpitations 42.45 11.26 148 261921 35821 32215636
Device issue 42.12 11.26 10 262059 8902 32242555
Ocular hypertension 42.02 11.26 42 262027 784 32250673
Back pain 41.88 11.26 1182 260887 109871 32141586
Delusion 41.83 11.26 27 262042 13081 32238376
Adenocarcinoma of colon 41.66 11.26 89 261980 3400 32248057
Cardio-respiratory arrest 41.64 11.26 272 261797 55717 32195740
Myelopathy 41.62 11.26 66 262003 1997 32249460
Spinal compression fracture 41.60 11.26 134 261935 6582 32244875
Glycosylated haemoglobin increased 41.27 11.26 16 262053 10373 32241084
Primary amyloidosis 40.83 11.26 21 262048 124 32251333
Diffuse large B-cell lymphoma 40.46 11.26 155 261914 8307 32243150
Metastases to central nervous system 40.03 11.26 145 261924 7563 32243894
Escherichia sepsis 39.91 11.26 100 261969 4248 32247209
Atrial fibrillation 39.88 11.26 1227 260842 115477 32135980
Malignant neoplasm of unknown primary site 39.74 11.26 30 262039 376 32251081
Akathisia 39.49 11.26 5 262064 7020 32244437
Autonomic neuropathy 39.46 11.26 43 262026 891 32250566
Arteriosclerosis 39.10 11.26 20 262049 11014 32240443
Obstructive airways disorder 39.05 11.26 24 262045 11937 32239520
Taste disorder 38.76 11.26 104 261965 4607 32246850
Plasma cell myeloma refractory 38.76 11.26 16 262053 51 32251406
Type 2 diabetes mellitus 38.73 11.26 39 262030 15133 32236324
Blood pressure systolic increased 38.67 11.26 50 262019 17346 32234111
Kidney transplant rejection 38.07 11.26 8 262061 7747 32243710
Cellulitis orbital 37.96 11.26 28 262041 338 32251119
Cytomegalovirus infection reactivation 37.85 11.26 84 261985 3295 32248162
Product administration error 37.83 11.26 42 262027 15583 32235874
Substance abuse 37.75 11.26 6 262063 7101 32244356
Peripheral motor neuropathy 37.72 11.26 58 262011 1708 32249749
Injection site swelling 37.67 11.26 15 262054 9569 32241888
Drug level increased 37.57 11.26 65 262004 20015 32231442
Cardiac failure congestive 37.34 11.26 471 261598 84381 32167076
Embolism 37.27 11.26 138 261931 7276 32244181
Choroiditis 37.23 11.26 45 262024 1047 32250410
Panic attack 37.22 11.26 14 262055 9247 32242210
Parkinsonism 36.86 11.26 9 262060 7860 32243597
Hyperviscosity syndrome 36.68 11.26 23 262046 208 32251249
Underdose 36.43 11.26 31 262038 13038 32238419
Hypogammaglobulinaemia 36.26 11.26 121 261948 6055 32245402
Coronary artery occlusion 36.18 11.26 24 262045 11461 32239996
Hypertension 36.05 11.26 798 261271 130952 32120505
Dizziness 36.00 11.26 1354 260715 208264 32043193
Rectal haemorrhage 35.94 11.26 167 261902 37256 32214201
Haematuria 35.93 11.26 235 261834 48126 32203331
Injection site haemorrhage 35.80 11.26 12 262057 8516 32242941
Prescribed overdose 35.65 11.26 16 262053 9503 32241954
Transplant rejection 35.62 11.26 18 262051 9981 32241476
Cardiac amyloidosis 35.60 11.26 42 262027 952 32250505
Substance-induced psychotic disorder 35.52 11.26 53 262016 1519 32249938
Exposure during pregnancy 35.38 11.26 15 262054 9214 32242243
Anhedonia 35.37 11.26 12 262057 8452 32243005
Abdominal pain 35.34 11.26 926 261143 148603 32102854
Peripheral swelling 35.21 11.26 759 261310 67586 32183871
Visual acuity reduced 35.05 11.26 240 261829 16205 32235252
Cardiac arrest 34.55 11.26 560 261509 96216 32155241
Visceral leishmaniasis 34.47 11.26 32 262037 543 32250914
Eczema 34.40 11.26 42 262027 14938 32236519
Psychotic disorder 34.21 11.26 85 261984 22935 32228522
Sexual dysfunction 34.11 11.26 5 262064 6284 32245173
Hyperlipidaemia 34.06 11.26 40 262029 14471 32236986
Febrile infection 34.01 11.26 63 262006 2166 32249291
Differentiation syndrome 33.85 11.26 46 262023 1207 32250250
Compression fracture 33.79 11.26 75 261994 2942 32248515
Basal cell carcinoma 33.73 11.26 250 261819 17318 32234139
Seasonal allergy 33.68 11.26 107 261962 5217 32246240
Tardive dyskinesia 33.49 11.26 3 262066 5528 32245929
Minimal residual disease 33.47 11.26 25 262044 308 32251149
Hallucination, auditory 33.46 11.26 21 262048 10329 32241128
Extrapyramidal disorder 33.42 11.26 28 262041 11867 32239590
Pulmonary arterial hypertension 33.05 11.26 19 262050 9802 32241655
Ischaemic cardiomyopathy 32.92 11.26 6 262063 6428 32245029
Mitral valve incompetence 32.79 11.26 43 262026 14828 32236629
Pancreatitis 32.78 11.26 177 261892 37974 32213483
Road traffic accident 32.76 11.26 56 262013 17325 32234132
Angina pectoris 32.75 11.26 136 261933 31290 32220167
Device malfunction 32.61 11.26 16 262053 9023 32242434
Haematochezia 32.54 11.26 184 261885 39024 32212433
Obesity 32.45 11.26 21 262048 10161 32241296
Dystonia 32.40 11.26 23 262046 10600 32240857
Paraplegia 32.39 11.26 70 261999 2696 32248761
Bradycardia 32.32 11.26 395 261674 71167 32180290
Refractory anaemia with an excess of blasts 32.06 11.26 27 262042 400 32251057
Dehydration 31.72 11.26 1306 260763 127652 32123805
Therapeutic product effect incomplete 31.67 11.26 199 261870 41142 32210315
Aplasia 31.58 11.26 93 261976 4349 32247108
Mobility decreased 31.47 11.26 120 261949 28289 32223168
Cholestasis 31.38 11.26 112 261957 26921 32224536
Red blood cell sedimentation rate increased 31.23 11.26 12 262057 7823 32243634
B precursor type acute leukaemia 31.06 11.26 18 262051 139 32251318
Paranoia 30.86 11.26 25 262044 10774 32240683
Refractory cytopenia with multilineage dysplasia 30.84 11.26 18 262051 141 32251316
Osteoarthritis 30.74 11.26 71 261998 19648 32231809
Herpes zoster 30.71 11.26 397 261672 31944 32219513
Candida infection 30.51 11.26 236 261833 16567 32234890
Diverticular perforation 30.42 11.26 76 261993 3222 32248235
Cardiac murmur 30.39 11.26 10 262059 7181 32244276
B-cell lymphoma recurrent 30.34 11.26 32 262037 638 32250819
Heart block congenital 30.10 11.26 12 262057 34 32251423
Coronary artery bypass 30.08 11.26 3 262066 5073 32246384
Anger 29.93 11.26 31 262038 11873 32239584
Vertebral lesion 29.93 11.26 19 262050 176 32251281
Joint stiffness 29.84 11.26 22 262047 9943 32241514
Chronic kidney disease 29.82 11.26 194 261875 39781 32211676
Tricuspid valve incompetence 29.81 11.26 19 262050 9268 32242189
Injection site bruising 29.51 11.26 13 262056 7807 32243650
Disseminated aspergillosis 29.42 11.26 21 262048 240 32251217
Miosis 29.06 11.26 17 262052 8687 32242770
Meningitis pneumococcal 29.04 11.26 17 262052 134 32251323
Blood creatinine increased 29.01 11.26 573 261496 95559 32155898
Blood loss anaemia 28.87 11.26 14 262055 7948 32243509
Haematoma 28.77 11.26 108 261961 25576 32225881
Nephrolithiasis 28.74 11.26 118 261951 27236 32224221
Pain in extremity 28.69 11.26 734 261335 118167 32133290
Injection site pruritus 28.46 11.26 7 262062 6083 32245374
Ankylosing spondylitis 28.45 11.26 4 262065 5186 32246271
Hepatitis B reactivation 28.24 11.26 76 261993 3373 32248084
Middle insomnia 27.44 11.26 9 262060 6475 32244982
Knee arthroplasty 27.40 11.26 7 262062 5930 32245527
Gastrooesophageal reflux disease 27.24 11.26 166 261903 34572 32216885
Protein total increased 27.23 11.26 58 262011 2211 32249246
Metapneumovirus infection 27.21 11.26 30 262039 630 32250827
Blood calcium increased 27.19 11.26 76 261993 3449 32248008
Disturbance in attention 27.18 11.26 99 261970 23654 32227803
Faeces discoloured 27.07 11.26 49 262020 14828 32236629
Injection site reaction 27.03 11.26 32 262037 11537 32239920
Peripheral sensorimotor neuropathy 26.97 11.26 45 262024 1422 32250035
Pulmonary function test decreased 26.88 11.26 4 262065 4971 32246486
Frequent bowel movements 26.87 11.26 22 262047 9430 32242027
Cataract subcapsular 26.86 11.26 23 262046 349 32251108
Salivary hypersecretion 26.72 11.26 16 262053 8072 32243385
Hepatocellular carcinoma 26.68 11.26 26 262043 10244 32241213
Pneumonia escherichia 26.49 11.26 23 262046 356 32251101
Pulmonary hypertension 26.48 11.26 81 261988 20413 32231044
Chronic obstructive pulmonary disease 26.44 11.26 258 261811 48495 32202962
Malaise 26.36 11.26 1163 260906 175975 32075482
Injection site mass 26.34 11.26 6 262063 5495 32245962
Multiple allergies 26.32 11.26 58 262011 2264 32249193
Arthritis 26.29 11.26 118 261951 26574 32224883
Diabetic ketoacidosis 26.04 11.26 67 262002 17865 32233592
Bacterial sepsis 26.01 11.26 98 261971 5210 32246247
Benign prostatic hyperplasia 26.01 11.26 37 262032 12327 32239130
Keratitis fungal 26.01 11.26 14 262055 92 32251365
Skin striae 25.98 11.26 26 262043 486 32250971
Light chain disease 25.97 11.26 15 262054 115 32251342
Blood urea increased 25.95 11.26 153 261916 32120 32219337
Liver function test abnormal 25.93 11.26 151 261918 31796 32219661
Immunosuppressant drug level increased 25.90 11.26 5 262064 5140 32246317
Decreased appetite 25.88 11.26 1563 260506 159250 32092207
Cerebral venous thrombosis 25.83 11.26 29 262040 622 32250835
Drug level decreased 25.48 11.26 10 262059 6436 32245021
Product storage error 25.45 11.26 13 262056 7165 32244292
Negative pressure pulmonary oedema 25.27 11.26 18 262051 205 32251252
Dyslipidaemia 25.11 11.26 12 262057 6871 32244586
Schizophrenia 25.10 11.26 26 262043 9958 32241499
Drug reaction with eosinophilia and systemic symptoms 25.07 11.26 156 261913 32329 32219128
Pneumonitis 24.97 11.26 361 261708 29773 32221684
C-reactive protein abnormal 24.90 11.26 10 262059 6346 32245111
Escherichia bacteraemia 24.84 11.26 69 262000 3120 32248337
Hyperhidrosis 24.67 11.26 414 261655 70754 32180703
Coombs positive haemolytic anaemia 24.62 11.26 32 262037 803 32250654
Arteriosclerosis coronary artery 24.55 11.26 36 262033 11845 32239612
Second primary malignancy 24.54 11.26 116 261953 6825 32244632
Atrial septal defect 24.50 11.26 13 262056 7012 32244445
Device leakage 24.43 11.26 4 262065 4632 32246825
Blood immunoglobulin M increased 24.43 11.26 17 262052 186 32251271
Pneumonia viral 24.43 11.26 65 262004 2865 32248592
Blood potassium increased 24.23 11.26 63 262006 16741 32234716
Blood triglycerides increased 24.13 11.26 51 262018 14568 32236889
Angina unstable 24.03 11.26 39 262030 12316 32239141
Adrenal insufficiency 23.95 11.26 172 261897 11796 32239661
Progressive multifocal leukoencephalopathy 23.94 11.26 145 261924 9386 32242071
Therapeutic product effect decreased 23.91 11.26 149 261920 30868 32220589
Rectal adenocarcinoma 23.85 11.26 32 262037 829 32250628
Performance status decreased 23.80 11.26 80 261989 4018 32247439
Corneal perforation 23.78 11.26 16 262053 165 32251292
Ecthyma 23.62 11.26 22 262047 375 32251082
Fall 23.59 11.26 1317 260752 194884 32056573
Eye pain 23.59 11.26 182 261887 12766 32238691
Respiratory failure 23.34 11.26 1072 260997 106110 32145347
Viral haemorrhagic cystitis 23.27 11.26 33 262036 902 32250555
Alcohol abuse 23.25 11.26 4 262065 4468 32246989
Withdrawal syndrome 22.90 11.26 39 262030 12083 32239374
Tendonitis 22.82 11.26 22 262047 8713 32242744
Blood pressure measurement 22.48 11.26 16 262053 182 32251275
Nephrogenic systemic fibrosis 22.40 11.26 4 262065 4348 32247109
Hepatitis cholestatic 22.33 11.26 20 262049 8205 32243252
Cerebral haemorrhage 22.33 11.26 176 261893 34571 32216886
Gastric ulcer 22.24 11.26 60 262009 15749 32235708
Staphylococcal bacteraemia 22.24 11.26 119 261950 7357 32244100
Neutropenic colitis 22.22 11.26 58 262011 2527 32248930
Hepatic encephalopathy 22.13 11.26 55 262014 14840 32236617
Accidental exposure to product 22.13 11.26 35 262034 11167 32240290
Hypertriglyceridaemia 22.13 11.26 133 261936 8586 32242871
Therapeutic response unexpected 22.02 11.26 27 262042 9585 32241872
Complications of transplanted kidney 21.95 11.26 4 262065 4286 32247171
Neoplasm recurrence 21.94 11.26 50 262019 1997 32249460
Bradykinesia 21.92 11.26 4 262065 4282 32247175
Malignant transformation 21.91 11.26 30 262039 793 32250664
Aspergillus infection 21.82 11.26 164 261905 11410 32240047
Haematemesis 21.70 11.26 132 261937 27503 32223954
Pruritus 21.68 11.26 833 261236 127869 32123588
Cardiac failure chronic 21.66 11.26 16 262053 7224 32244233
Oral pain 21.49 11.26 146 261923 9832 32241625
Large intestine polyp 21.46 11.26 16 262053 7190 32244267
Therapy non-responder 21.33 11.26 376 261693 32278 32219179
Pulmonary fibrosis 21.28 11.26 68 262001 16906 32234551
Immunosuppression 21.25 11.26 96 261973 5541 32245916
Familial periodic paralysis 21.21 11.26 12 262057 88 32251369
Disability 21.10 11.26 6 262063 4734 32246723
Heart rate decreased 21.05 11.26 118 261951 25082 32226375
Intestinal perforation 21.02 11.26 133 261936 8742 32242715
JC virus infection 21.00 11.26 48 262021 1921 32249536
Priapism 20.99 11.26 7 262062 4984 32246473
Pulmonary congestion 20.96 11.26 47 262022 13144 32238313
Nocardiosis 20.94 11.26 72 261997 3659 32247798
Coronary artery stenosis 20.90 11.26 29 262040 9764 32241693
Oral candidiasis 20.78 11.26 167 261902 11860 32239597
Vascular pain 20.76 11.26 14 262055 145 32251312
Eosinophil count increased 20.74 11.26 22 262047 8333 32243124
Pseudomonas infection 20.61 11.26 167 261902 11889 32239568
Cardiomegaly 20.61 11.26 58 262011 15013 32236444
Hypotony of eye 20.51 11.26 13 262056 120 32251337
Periorbital infection 20.51 11.26 13 262056 120 32251337
Crying 20.43 11.26 11 262058 5885 32245572
Paraproteinaemia 20.39 11.26 19 262050 324 32251133
Blood immunoglobulin G increased 20.33 11.26 31 262038 906 32250551
Myocardial ischaemia 20.33 11.26 74 261995 17685 32233772
Pneumonia aspiration 20.19 11.26 223 261846 40933 32210524
Autoimmune lymphoproliferative syndrome 20.13 11.26 14 262055 153 32251304
Dysgeusia 20.03 11.26 303 261766 25228 32226229
Electrocardiogram QRS complex prolonged 19.98 11.26 6 262063 4568 32246889
Renal injury 19.95 11.26 42 262027 12013 32239444
Pneumoretroperitoneum 19.87 11.26 10 262059 56 32251401
Muscle spasticity 19.87 11.26 11 262058 5794 32245663
Chalazion 19.85 11.26 12 262057 101 32251356
Hypocalcaemia 19.83 11.26 278 261791 22776 32228681
Respiratory rate increased 19.68 11.26 28 262041 9329 32242128
Rash pruritic 19.67 11.26 293 261776 24318 32227139
Iron deficiency anaemia 19.46 11.26 30 262039 9671 32241786
Colitis 19.43 11.26 383 261686 33568 32217889
Pneumonia fungal 19.39 11.26 101 261968 6179 32245278
Heart rate irregular 19.38 11.26 54 262015 14024 32237433
Acute lymphocytic leukaemia refractory 19.37 11.26 12 262057 106 32251351
Meningitis bacterial 19.33 11.26 35 262034 1182 32250275
Streptococcal bacteraemia 19.33 11.26 44 262025 1756 32249701
Intraocular pressure decreased 19.28 11.26 12 262057 107 32251350
Depressed mood 19.19 11.26 79 261990 18221 32233236
Right ventricular failure 19.15 11.26 24 262045 8439 32243018
Prescribed underdose 19.13 11.26 25 262044 8634 32242823
Disseminated strongyloidiasis 19.08 11.26 11 262058 84 32251373
Hiatus hernia 19.07 11.26 20 262049 7616 32243841
Swollen tongue 19.01 11.26 52 262017 13587 32237870
Macular fibrosis 19.01 11.26 21 262048 442 32251015
Urticaria 18.99 11.26 352 261717 59262 32192195
Sputum discoloured 18.96 11.26 20 262049 7596 32243861
Obsessive-compulsive disorder 18.94 11.26 8 262061 4926 32246531
Gallbladder oedema 18.92 11.26 15 262054 203 32251254
Forced expiratory volume decreased 18.89 11.26 3 262066 3553 32247904
Gastritis 18.89 11.26 101 261968 21726 32229731
Varicella zoster virus infection 18.85 11.26 40 262029 1521 32249936
Hypokinesia 18.85 11.26 24 262045 8381 32243076
Pulmonary mucormycosis 18.84 11.26 23 262046 541 32250916
Diabetes mellitus inadequate control 18.81 11.26 53 262016 13715 32237742
Bacterial infection 18.79 11.26 184 261885 13822 32237635
Blood stem cell transplant failure 18.75 11.26 20 262049 404 32251053
Upper gastrointestinal haemorrhage 18.68 11.26 114 261955 23735 32227722
Respirovirus test positive 18.54 11.26 10 262059 66 32251391
Product complaint 18.45 11.26 12 262057 5791 32245666
Tubulointerstitial nephritis 18.42 11.26 88 261981 19489 32231968
Body tinea 18.42 11.26 10 262059 67 32251390
Human herpesvirus 6 encephalitis 18.39 11.26 15 262054 212 32251245
Haemorrhage 18.34 11.26 284 261785 49164 32202293
Steroid withdrawal syndrome 18.33 11.26 15 262054 213 32251244
Testicular germ cell cancer metastatic 18.30 11.26 10 262059 68 32251389
Fungal oesophagitis 18.27 11.26 18 262051 330 32251127
Cardiogenic shock 18.22 11.26 95 261974 20567 32230890
Glioblastoma 18.19 11.26 34 262035 1177 32250280
Fungal sepsis 18.16 11.26 30 262039 940 32250517
Neutropenic infection 18.03 11.26 35 262034 1247 32250210
Necrotising retinitis 18.02 11.26 28 262041 832 32250625
Multiple organ dysfunction syndrome 17.97 11.26 711 261358 69143 32182314
Back disorder 17.97 11.26 101 261968 6362 32245095
Electrocardiogram abnormal 17.93 11.26 22 262047 7808 32243649
Restlessness 17.92 11.26 122 261947 24759 32226698
Syringe issue 17.87 11.26 4 262065 3707 32247750
Aeromonas infection 17.86 11.26 17 262052 298 32251159
Blood glucose decreased 17.84 11.26 53 262016 13481 32237976
Altered state of consciousness 17.83 11.26 104 261965 21893 32229564
Glioblastoma multiforme 17.83 11.26 28 262041 840 32250617
Blood cholesterol increased 17.79 11.26 78 261991 17679 32233778
Atrial flutter 17.77 11.26 194 261875 14989 32236468
Corneal lesion 17.77 11.26 7 262062 19 32251438
Acute myocardial infarction 17.77 11.26 325 261744 54824 32196633
Diverticulum 17.76 11.26 18 262051 6964 32244493
White blood cell count increased 17.76 11.26 231 261838 41171 32210286
Mental disorder 17.74 11.26 59 262010 14489 32236968
Hypothermia 17.74 11.26 34 262035 10069 32241388
Lactose intolerance 17.73 11.26 35 262034 1263 32250194
Taeniasis 17.72 11.26 10 262059 73 32251384
Irritability 17.70 11.26 121 261948 24533 32226924
Central nervous system vasculitis 17.70 11.26 20 262049 432 32251025
Immunoglobulins increased 17.69 11.26 14 262055 189 32251268
Ear swelling 17.67 11.26 20 262049 433 32251024
Abnormal dreams 17.65 11.26 26 262043 8538 32242919
Pallor 17.59 11.26 110 261959 22771 32228686
B-cell type acute leukaemia 17.50 11.26 17 262052 306 32251151
Rhinocerebral mucormycosis 17.50 11.26 12 262057 128 32251329
Chromaturia 17.46 11.26 59 262010 14419 32237038
Mantle cell lymphoma recurrent 17.46 11.26 21 262048 486 32250971
Flushing 17.43 11.26 350 261719 30777 32220680
Myoclonus 17.38 11.26 60 262009 14569 32236888
Upper respiratory tract infection 17.38 11.26 334 261735 29139 32222318
Lip swelling 17.36 11.26 55 262014 13710 32237747
Hypoxia 17.22 11.26 546 261523 51586 32199871
Photosensitivity reaction 17.16 11.26 35 262034 10128 32241329
Blood immunoglobulin A increased 17.11 11.26 17 262052 315 32251142
Syncope 17.05 11.26 575 261494 89549 32161908
Pneumonia bacterial 17.02 11.26 146 261923 10570 32240887
Light chain analysis abnormal 16.96 11.26 10 262059 80 32251377
Gait disturbance 16.90 11.26 506 261563 79902 32171555
Hordeolum 16.86 11.26 27 262042 824 32250633
Disseminated cryptococcosis 16.84 11.26 32 262037 1122 32250335
Joint range of motion decreased 16.82 11.26 15 262054 6167 32245290
Aspiration bone marrow abnormal 16.80 11.26 11 262058 108 32251349
Ventricular fibrillation 16.76 11.26 77 261992 17233 32234224
Hypothyroidism 16.74 11.26 75 261994 16900 32234557
Inflammation 16.71 11.26 122 261947 24371 32227086
Central nervous system leukaemia 16.65 11.26 16 262053 284 32251173
Cerebral haematoma 16.63 11.26 9 262060 4802 32246655
Foot deformity 16.61 11.26 6 262063 4064 32247393
Weight fluctuation 16.47 11.26 74 261995 4261 32247196
Oroantral fistula 16.42 11.26 15 262054 249 32251208
Musculoskeletal pain 16.38 11.26 171 261898 31726 32219731
Capillary leak syndrome 16.38 11.26 43 262026 1880 32249577
Protein total abnormal 16.31 11.26 17 262052 334 32251123
Influenza like illness 16.28 11.26 140 261929 27000 32224457
Umbilical hernia 16.27 11.26 7 262062 4263 32247194
Encephalitis brain stem 16.27 11.26 10 262059 87 32251370
Hepatitis 16.17 11.26 118 261951 23575 32227882
Abdominal discomfort 16.06 11.26 313 261756 52311 32199146
Disorientation 16.04 11.26 182 261887 33243 32218214
Gastritis erosive 15.95 11.26 15 262054 6012 32245445
Multiple sclerosis 15.95 11.26 23 262046 7621 32243836
Monoclonal gammopathy 15.87 11.26 16 262053 302 32251155
Posterior capsule rupture 15.86 11.26 6 262063 14 32251443
Pneumonia parainfluenzae viral 15.84 11.26 11 262058 120 32251337
Clostridium difficile colitis 15.81 11.26 181 261888 14150 32237307
SARS-CoV-2 test positive 15.73 11.26 52 262017 2589 32248868
Toxic skin eruption 15.65 11.26 45 262024 11569 32239888
Lentigo maligna 15.62 11.26 15 262054 266 32251191
Seizure 15.60 11.26 681 261388 103173 32148284
Glomerular filtration rate decreased 15.59 11.26 52 262017 12759 32238698
Rib fracture 15.59 11.26 176 261893 13713 32237744
Pericardial haemorrhage 15.53 11.26 3 262066 3083 32248374
Idiopathic pulmonary fibrosis 15.52 11.26 8 262061 4387 32247070
Coordination abnormal 15.50 11.26 24 262045 7724 32243733
Haemodialysis 15.48 11.26 42 262027 11004 32240453
Interstitial lung disease 15.47 11.26 402 261667 64599 32186858
Immune effector cell-associated neurotoxicity syndrome 15.38 11.26 37 262032 1531 32249926
Bundle branch block right 15.37 11.26 23 262046 7505 32243952
Brain oedema 15.36 11.26 166 261903 12794 32238663
Cerebrovascular accident 15.35 11.26 555 261514 85765 32165692
Steroid diabetes 15.34 11.26 41 262028 1812 32249645
Peripheral vascular disorder 15.32 11.26 12 262057 5260 32246197
VIIIth nerve lesion 15.32 11.26 4 262065 0 32251457
Dysphonia 15.28 11.26 243 261826 20441 32231016
Intestinal atresia 15.27 11.26 9 262060 72 32251385
Sleep disorder due to a general medical condition 15.26 11.26 4 262065 3330 32248127
Stem cell transplant 15.24 11.26 46 262023 2181 32249276
Hypertonia 15.22 11.26 10 262059 4799 32246658
Corneal abscess 15.21 11.26 7 262062 31 32251426
Ejection fraction decreased 15.12 11.26 82 261987 17576 32233881
Corneal degeneration 15.04 11.26 7 262062 32 32251425
Keratitis bacterial 14.96 11.26 9 262060 75 32251382
Pregnancy of partner 14.93 11.26 16 262053 325 32251132
Mydriasis 14.88 11.26 18 262051 6428 32245029
Duodenal ulcer haemorrhage 14.87 11.26 11 262058 4963 32246494
Nicotinic acid deficiency 14.77 11.26 9 262060 77 32251380
Enterocolitis infectious 14.74 11.26 32 262037 1236 32250221
Post procedural complication 14.72 11.26 48 262021 11859 32239598
Spinal disorder 14.69 11.26 65 262004 3718 32247739
Blood pressure diastolic decreased 14.68 11.26 22 262047 7175 32244282
VIth nerve disorder 14.56 11.26 6 262063 19 32251438
Pneumonia pneumococcal 14.51 11.26 42 262027 1945 32249512
Vitreous loss 14.43 11.26 5 262064 8 32251449
Lower gastrointestinal haemorrhage 14.35 11.26 31 262038 8786 32242671
Corneal disorder 14.32 11.26 25 262044 820 32250637
Tumour perforation 14.26 11.26 15 262054 298 32251159
Corneal thinning 14.24 11.26 11 262058 143 32251314
Enterococcal infection 14.20 11.26 124 261945 9023 32242434
Speech disorder 14.20 11.26 139 261930 26114 32225343
Granulocytopenia 14.20 11.26 19 262050 6496 32244961
Transitional cell cancer of the renal pelvis and ureter 14.12 11.26 6 262063 21 32251436
Panophthalmitis 14.12 11.26 6 262063 21 32251436
Hypopyon 14.11 11.26 19 262050 494 32250963
Meningoradiculitis 14.08 11.26 7 262062 38 32251419
Electrocardiogram Q waves 14.08 11.26 7 262062 38 32251419
Aspiration 14.04 11.26 45 262024 11178 32240279
Productive cough 14.03 11.26 192 261877 33924 32217533
Corneal infiltrates 13.98 11.26 13 262056 221 32251236
Pneumonia respiratory syncytial viral 13.96 11.26 25 262044 837 32250620
Discomfort 13.92 11.26 73 261996 15782 32235675
Acidosis 13.92 11.26 43 262026 10803 32240654
Renal cyst 13.91 11.26 31 262038 8688 32242769
Exercise tolerance decreased 13.90 11.26 10 262059 4578 32246879
Renal amyloidosis 13.89 11.26 8 262061 61 32251396
Cholelithiasis 13.87 11.26 105 261964 20807 32230650
Hypercholesterolaemia 13.86 11.26 27 262042 7947 32243510
Stent placement 13.83 11.26 10 262059 4565 32246892
Cytomegalovirus infection 13.82 11.26 285 261784 25179 32226278
Alcohol use 13.79 11.26 5 262064 3378 32248079
Post procedural infection 13.77 11.26 11 262058 4774 32246683
Duodenal ulcer 13.74 11.26 41 262028 10414 32241043
Autologous haematopoietic stem cell transplant 13.73 11.26 5 262064 10 32251447
Uveitis 13.73 11.26 93 261976 6257 32245200
Keratitis 13.72 11.26 31 262038 1231 32250226
Dysuria 13.71 11.26 132 261937 24878 32226579
Eosinophilic pneumonia 13.70 11.26 4 262065 3102 32248355
Immune reconstitution inflammatory syndrome 13.66 11.26 36 262033 9523 32241934
POEMS syndrome 13.66 11.26 7 262062 41 32251416
No adverse event 13.63 11.26 100 261969 19953 32231504
Joint injury 13.62 11.26 25 262044 7525 32243932
Vocal cord paresis 13.61 11.26 10 262059 120 32251337
Personality change due to a general medical condition 13.52 11.26 7 262062 42 32251415
Refeeding syndrome 13.52 11.26 7 262062 42 32251415
Hypertransaminasaemia 13.50 11.26 68 262001 4106 32247351
Blood culture positive 13.47 11.26 78 261991 4967 32246490
Nephrotic syndrome 13.46 11.26 24 262045 7305 32244152
Liver disorder 13.43 11.26 177 261892 31477 32219980
Fibromyalgia 13.40 11.26 3 262066 2781 32248676
Listeriosis 13.38 11.26 26 262043 927 32250530
Dyspnoea exertional 13.38 11.26 227 261842 38734 32212723
Sternal fracture 13.37 11.26 21 262048 630 32250827
Paraesthesia 13.35 11.26 592 261477 58352 32193105
Catatonia 13.33 11.26 11 262058 4697 32246760
Retinal detachment 13.28 11.26 80 261989 5168 32246289
Herpes simplex reactivation 13.26 11.26 7 262062 44 32251413
Jaw disorder 13.23 11.26 45 262024 2274 32249183
Skin plaque 13.20 11.26 8 262061 4009 32247448
Drug-induced liver injury 13.19 11.26 127 261942 23936 32227521
Gastrointestinal toxicity 13.18 11.26 43 262026 2126 32249331
Staphylococcal sepsis 13.18 11.26 130 261939 9783 32241674
Basosquamous carcinoma of skin 13.12 11.26 5 262064 12 32251445
Status epilepticus 13.11 11.26 51 262018 11955 32239502
Disseminated coccidioidomycosis 13.10 11.26 4 262065 3 32251454
Plasma cells present 13.10 11.26 4 262065 3 32251454
Shock haemorrhagic 13.10 11.26 43 262026 10602 32240855
VIth nerve paralysis 13.08 11.26 23 262046 759 32250698
Orthopnoea 13.07 11.26 13 262056 5074 32246383
Corneal deposits 13.05 11.26 12 262057 201 32251256
Hip deformity 13.05 11.26 9 262060 97 32251360
Neck pain 13.03 11.26 119 261950 22668 32228789
Head injury 13.03 11.26 86 261983 17577 32233880
Lymphocyte count decreased 13.02 11.26 241 261828 20878 32230579
Hyperreflexia 13.01 11.26 4 262065 3000 32248457
Unresponsive to stimuli 12.99 11.26 151 261918 27458 32223999
Cellulitis enterococcal 12.96 11.26 6 262063 27 32251430
Hypogeusia 12.93 11.26 25 262044 888 32250569
Thrombophlebitis superficial 12.90 11.26 51 262018 2774 32248683
Glaucoma 12.89 11.26 93 261976 6387 32245070
Cellulitis streptococcal 12.88 11.26 7 262062 47 32251410
Needle issue 12.86 11.26 10 262059 4399 32247058
Injury corneal 12.84 11.26 5 262064 13 32251444
Feeling cold 12.84 11.26 40 262029 10024 32241433
Somnambulism 12.80 11.26 5 262064 3227 32248230
Injection site induration 12.71 11.26 3 262066 2681 32248776
Hepatic steatosis 12.69 11.26 77 261992 16056 32235401
Normochromic normocytic anaemia 12.67 11.26 9 262060 4146 32247311
Device related infection 12.62 11.26 209 261860 17724 32233733
Memory impairment 12.58 11.26 240 261829 40239 32211218
Atypical haemolytic uraemic syndrome 12.58 11.26 11 262058 172 32251285
Diabetic hyperosmolar coma 12.57 11.26 16 262053 393 32251064
Vitamin D deficiency 12.54 11.26 18 262051 5976 32245481
Squamous cell carcinoma of head and neck 12.53 11.26 11 262058 173 32251284
Leukoencephalopathy 12.50 11.26 66 262003 4059 32247398
Systemic lupus erythematosus 12.49 11.26 4 262065 2922 32248535
Bacillus test positive 12.46 11.26 6 262063 30 32251427
Tooth deposit 12.46 11.26 9 262060 105 32251352
Gastric perforation 12.45 11.26 43 262026 2190 32249267
Spinal pain 12.44 11.26 76 261993 4935 32246522
Blindness 12.40 11.26 161 261908 12965 32238492
Chemotherapeutic drug level increased 12.40 11.26 12 262057 215 32251242
Blood pressure decreased 12.39 11.26 315 261754 50765 32200692
Presyncope 12.38 11.26 85 261984 17216 32234241
Exposed bone in jaw 12.37 11.26 38 262031 1819 32249638
Gastrointestinal wall thinning 12.33 11.26 5 262064 15 32251442
Squamous cell carcinoma of the hypopharynx 12.33 11.26 5 262064 15 32251442
Peritumoural oedema 12.33 11.26 5 262064 15 32251442
Guillain-Barre syndrome 12.33 11.26 81 261988 5393 32246064
Developmental delay 12.32 11.26 3 262066 2625 32248832
Central vision loss 12.31 11.26 6 262063 31 32251426
Therapy responder 12.22 11.26 11 262058 179 32251278
Product dispensing error 12.22 11.26 21 262048 6484 32244973
Superior sagittal sinus thrombosis 12.19 11.26 14 262055 308 32251149
Congenital herpes simplex infection 12.19 11.26 7 262062 53 32251404
Abdominal pain upper 12.18 11.26 432 261637 66906 32184551
Red blood cell count decreased 12.18 11.26 302 261767 27511 32223946
Anal inflammation 12.18 11.26 15 262054 356 32251101
Sarcoidosis 12.17 11.26 4 262065 2875 32248582
Secondary immunodeficiency 12.15 11.26 15 262054 357 32251100
Epstein-Barr virus associated lymphoma 12.15 11.26 20 262049 625 32250832
Transformation to acute myeloid leukaemia 12.11 11.26 21 262048 685 32250772
Infection reactivation 12.11 11.26 28 262041 1129 32250328
Janeway lesion 12.10 11.26 5 262064 16 32251441
Incorrect route of product administration 12.06 11.26 51 262018 11675 32239782
High density lipoprotein decreased 11.99 11.26 6 262063 3346 32248111
Lymphadenitis 11.96 11.26 37 262032 1778 32249679
Hyperaemia 11.95 11.26 27 262042 1072 32250385
Haematoma muscle 11.95 11.26 26 262043 1006 32250451
Sleep disorder 11.94 11.26 148 261921 26604 32224853
Virologic failure 11.81 11.26 8 262061 3779 32247678
Concomitant disease aggravated 11.81 11.26 17 262052 5636 32245821
Atrioventricular block complete 11.80 11.26 35 262034 8909 32242548
Aplasia pure red cell 11.78 11.26 18 262051 5824 32245633
Hyperlactacidaemia 11.78 11.26 5 262064 3069 32248388
Nasal congestion 11.76 11.26 106 261963 20245 32231212
Jaundice 11.73 11.26 199 261870 33959 32217498
Thinking abnormal 11.72 11.26 17 262052 5618 32245839
Dry mouth 11.70 11.26 131 261938 23988 32227469
Superficial spreading melanoma stage II 11.70 11.26 4 262065 6 32251451
Cataract cortical 11.69 11.26 8 262061 85 32251372
Rhinovirus infection 11.65 11.26 56 262013 3317 32248140
Hypotension 11.65 11.26 1545 260524 214565 32036892
Ventricular septal defect 11.63 11.26 8 262061 3749 32247708
Hypoalbuminaemia 11.59 11.26 146 261923 11676 32239781
Encephalitis enteroviral 11.56 11.26 10 262059 154 32251303
Vitamin B complex deficiency 11.56 11.26 10 262059 154 32251303
Dysarthria 11.54 11.26 193 261876 33008 32218449
Hyponatraemia 11.52 11.26 487 261582 74026 32177431
Amyotrophy 11.51 11.26 18 262051 538 32250919
Adenocarcinoma of salivary gland 11.49 11.26 3 262066 0 32251457
Noninfective conjunctivitis 11.49 11.26 3 262066 0 32251457
Fibrin increased 11.49 11.26 3 262066 0 32251457
Herpes simplex meningitis 11.49 11.26 3 262066 0 32251457
Malignant mediastinal neoplasm 11.49 11.26 3 262066 0 32251457
Full blood count 11.49 11.26 3 262066 0 32251457
Lung squamous cell carcinoma stage II 11.49 11.26 3 262066 0 32251457
Nasal cavity mass 11.49 11.26 3 262066 0 32251457
Lymphocyte adoptive therapy 11.49 11.26 3 262066 0 32251457
Oropharyngeal candidiasis 11.49 11.26 22 262047 776 32250681
Aortic aneurysm 11.46 11.26 23 262046 6696 32244761
Noninfective encephalitis 11.46 11.26 6 262063 37 32251420
Epstein-Barr virus infection reactivation 11.45 11.26 17 262052 485 32250972
Perihepatic abscess 11.39 11.26 8 262061 89 32251368
Ascites 11.38 11.26 242 261827 39949 32211508
Pulmonary sepsis 11.38 11.26 41 262028 2133 32249324
Joint effusion 11.36 11.26 11 262058 4348 32247109
Hepatic cancer 11.34 11.26 26 262043 7214 32244243
Tumour marker abnormal 11.33 11.26 4 262065 7 32251450
Corneal endothelial cell loss 11.33 11.26 4 262065 7 32251450
Lung hypoinflation 11.33 11.26 4 262065 7 32251450
Nerve injury 11.32 11.26 54 262015 3189 32248268
Mean cell haemoglobin increased 11.31 11.26 28 262041 1180 32250277
Stomatitis necrotising 11.31 11.26 8 262061 90 32251367
Hyperdynamic left ventricle 11.31 11.26 8 262061 90 32251367
Adenoviral hepatitis 11.31 11.26 12 262057 241 32251216
C-reactive protein increased 11.30 11.26 298 261771 47804 32203653
Ventricular hypertrophy 11.28 11.26 14 262055 4944 32246513
Enterococcal bacteraemia 11.27 11.26 35 262034 1686 32249771
Body temperature decreased 11.26 11.26 48 262021 10966 32240491
Non-small cell lung cancer 11.26 11.26 62 262007 3875 32247582

Pharmacologic Action:

SourceCodeDescription
ATC A01AC02 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Corticosteroids for local oral treatment
ATC C05AA09 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AB19 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC D07XB05 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, moderately potent, other combinations
ATC D10AA03 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Corticosteroids, combinations for treatment of acne
ATC H02AB02 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD03 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC S01BA01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01CB01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA06 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC S03BA01 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS
Corticosteroids
ATC D07CB04 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, moderately potent, combinations with antibiotics
ATC R01AD53 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC S01CA01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S02CA06 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S03CA01 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000932 Antiemetics
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35705 immunosuppressant
CHEBI has role CHEBI:37962 adrenergic neuron agents
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Otitis externa indication 3135009
Keratitis indication 5888003 DOID:4677
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Cyclitis indication 17657000
Systemic AL amyloidosis indication 23132008
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Keloid scar indication 33659008
Crohn's disease indication 34000006
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Punctate keratitis indication 42513006 DOID:12197
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Iritis indication 65074000 DOID:1406
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Blepharoconjunctivitis indication 68659002 DOID:2456
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Perforation of cornea indication 74895004
Iridocyclitis indication 77971008
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Corneal abrasion indication 85848002
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Corneal ulcer indication 91514001 DOID:8463
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Multiple myeloma indication 109989006 DOID:9538
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Mycosis fungoides indication 118618005
Uveitis indication 128473001 DOID:13141
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Central retinal vein occlusion with macular edema indication 232039004
Branch retinal vein occlusion with macular edema indication 232048009
Malignant otitis externa due to Pseudomonas aeruginosa indication 232230009
Scalp psoriasis indication 238608008
Punctate keratopathy indication 246936005
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Infective otitis media indication 312218008
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Herpes zoster keratitis indication 397573005
Rosacea indication 398909004 DOID:8881
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Allergic otitis externa indication 405821001
Anterior uveitis indication 410692006 DOID:1407
Autoimmune hemolytic anemia indication 413603009 DOID:718
Allergic conjunctivitis indication 473460002 DOID:11204
Transfusion Reaction Urticaria indication
Erythroblastic Anemia indication
Synovitis due to Osteoarthritis indication
Post-Op Ocular Inflammation indication
Tuberculosis Meningitis Treatment Adjunct indication
Non-infectious Posterior Uveitis indication
Staphylococcus Aureus Otitis Externa indication
Progressive Diffuse Large B-Cell Lymphoma indication
Otitis Externa Seborrhea indication
Diagnostic Test for Cushing's Syndrome indication
Otitis Externa Eczema indication
Systemic Dermatomyositis indication
Pericarditis off-label use 3238004 DOID:1787
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Tendinitis off-label use 34840004 DOID:971
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Croup off-label use 71186008 DOID:9395
Pemphigoid off-label use 86142006
Myasthenia gravis off-label use 91637004 DOID:437
Polyarteritis nodosa off-label use 155441006 DOID:9810
Chemotherapy-induced nausea and vomiting off-label use 236084000
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Prevention of Post-Operative Nausea and Vomiting off-label use
Metastatic Prostate Carcinoma off-label use
Prevention of Radiation-Induced Nausea and Vomiting off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Endophthalmitis contraindication 1847009 DOID:4692
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Herpes simplex keratitis contraindication 9389005
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Glaucoma contraindication 23986001 DOID:1686
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Severe myopia contraindication 34187009
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Retinal detachment contraindication 42059000 DOID:5327
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Bacterial infection of eye contraindication 128984004
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Injury of eye region contraindication 282752000
Varicella-zoster virus infection contraindication 309465005
Viral eye infection contraindication 312132001
Viral ear infection contraindication 312137007
Osteopenia contraindication 312894000
Vaccinia keratitis contraindication 397552005
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Arginosuccinate Lyase Deficiency contraindication
Ornithine Carbamyltransferase Deficiency contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 12.45 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.3%;0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 9149486 Sept. 13, 2022 TREATMENT OF ACUTE OTITIS MEDIA
0.3%;0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 9345714 Sept. 13, 2022 TREATMENT OF ACUTE OTITIS MEDIA
0.3%;0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 9402805 Sept. 13, 2022 TREATMENT OF ACUTE OTITIS EXTERNA
0.3%;0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 9402805 Sept. 13, 2022 TREATMENT OF ACUTE OTITIS MEDIA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 10702539 Jan. 9, 2023 TREATMENT OF DIABETIC MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 10702539 Jan. 9, 2023 TREATMENT OF MACULAR EDEMA FOLLOWING BRANCH RETINAL VEIN OCCLUSION (BRVO) OR CENTRAL RETINAL VEIN OCCLUSION (CRVO)
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 10702539 Jan. 9, 2023 TREATMENT OF NON-INFECTIOUS UVEITIS AFFECTING THE POSTERIOR SEGMENT OF THE EYE
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8034366 Jan. 9, 2023 TREATMENT OF MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8034366 Jan. 9, 2023 TREATMENT OF UVEITIS
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8506987 Jan. 9, 2023 TREATMENT OF MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8506987 Jan. 9, 2023 TREATMENT OF UVEITIS
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 6899717 Nov. 1, 2023 DELIVERING AN OCULAR IMPLANT AS DESCRIBED IN THE DOSAGE AND ADMINISTRATION SECTION OF THE APPROVED LABELING OF OZURDEX
0.3%;0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 8846650 June 4, 2025 TREATMENT OF ACUTE OTITIS MEDIA
0.05%;0.3% TOBRADEX ST EYEVANCE N050818 Feb. 13, 2009 RX SUSPENSION/DROPS OPHTHALMIC 8101582 Dec. 19, 2027 USE OF A COMBINATION OF TOBRAMYCIN AND DEXAMETHASONE TO TREAT OCULAR INFLAMMATION WHERE AN INFECTION OR RISK OF INFECTION EXISTS
0.05%;0.3% TOBRADEX ST EYEVANCE N050818 Feb. 13, 2009 RX SUSPENSION/DROPS OPHTHALMIC 7795316 Aug. 3, 2028 USE OF A COMBINATION OF TOBRAMYCIN AND DEXAMETHASONE TO TREAT OCULAR INFLAMMATION WHERE AN INFECTION OR RISK OF INFECTION EXISTS
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC 8563027 Feb. 12, 2030 DEXTENZA IS APPROVED FOR THE TREATMENT OF OCULAR PAIN FOLLOWING OPHTHALMIC SURGERY
9% DEXYCU KIT EYEPOINT PHARMS N208912 Feb. 9, 2018 RX SUSPENSION INTRAOCULAR 10028965 May 23, 2034 TREATMENT OF POSTOPERATIVE INFLAMMATION
9% DEXYCU KIT EYEPOINT PHARMS N208912 Feb. 9, 2018 RX SUSPENSION INTRAOCULAR 10022502 June 22, 2034 TREATMENT OF POSTOPERATIVE INFLAMMATION

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
6MG DEXAMETHASONE AMNEAL A215106 Oct. 14, 2021 RX TABLET ORAL April 19, 2022 COMPETITIVE GENERIC THERAPY
4MG DEXAMETHASONE AMNEAL A215106 Oct. 14, 2021 RX TABLET ORAL April 20, 2022 COMPETITIVE GENERIC THERAPY
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC June 20, 2022 TREATMENT OF OCULAR INFLAMMATION FOLLOWING OPHTHALMIC SURGERY
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC Oct. 7, 2024 TREATMENT OF OCULAR ITCHING ASSOCIATED WITH ALLERGIC CONJUNCTIVITIS
20MG HEMADY DEXCEL PHARMA N211379 Oct. 3, 2019 RX TABLET ORAL Oct. 3, 2026 INDICATED IN COMBINATION WITH OTHER ANTI-MYELOMA PRODUCTS FOR THE TREATMENT OF ADULTS WITH MULTIPLE MYELOMA (MM)

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8.88 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK
Interleukin-5 Cytokine IC50 8.46 WOMBAT-PK
Mineralocorticoid receptor Nuclear hormone receptor EC50 9 WOMBAT-PK
Interleukin-4 Cytokine IC50 8.33 WOMBAT-PK
Androgen receptor Nuclear hormone receptor Ki 5.85 CHEMBL
Progesterone receptor Nuclear hormone receptor Ki 6.25 CHEMBL
Prostaglandin G/H synthase 2 Enzyme Ki 6.89 PDSP
Androgen receptor Transcription factor Ki 4.79 DRUG MATRIX
Fatty acid-binding protein, liver Unclassified Ki 4.66 CHEMBL
Progesterone receptor Transcription factor Ki 5.52 DRUG MATRIX
Glucocorticoid receptor Transcription factor IC50 7.66 CHEMBL
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor AGONIST EC50 6.10 IUPHAR

External reference:

IDSource
4017922 VUID
N0000146273 NUI
D00292 KEGG_DRUG
C0011777 UMLSCUI
CHEBI:41879 CHEBI
DEX PDB_CHEM_ID
CHEMBL384467 ChEMBL_ID
CHEMBL2021430 ChEMBL_ID
CHEMBL1200637 ChEMBL_ID
DB01234 DRUGBANK_ID
D003907 MESH_DESCRIPTOR_UI
5743 PUBCHEM_CID
2768 IUPHAR_LIGAND_ID
816 INN_ID
7S5I7G3JQL UNII
203704 RXNORM
4552 MMSL
6848 MMSL
6849 MMSL
d00206 MMSL
002174 NDDF
372584003 SNOMEDCT_US
7561000 SNOMEDCT_US
4017922 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
OZURDEX HUMAN PRESCRIPTION DRUG LABEL 1 0023-3348 IMPLANT 0.70 mg INTRAVITREAL NDA 24 sections
Dexamethasone Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3176 SOLUTION, CONCENTRATE 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-3177 SOLUTION 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4179 TABLET 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4180 TABLET 0.75 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4181 TABLET 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4182 TABLET 1.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4183 TABLET 2 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4184 TABLET 4 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4186 TABLET 6 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8174 TABLET 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8175 TABLET 4 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8176 TABLET 2 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8179 TABLET 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8180 TABLET 0.75 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8181 TABLET 1.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8183 TABLET 6 mg ORAL ANDA 20 sections
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0065-0631 OINTMENT 1 mg OPHTHALMIC NDA 18 sections
TobraDex HUMAN PRESCRIPTION DRUG LABEL 2 0065-0647 SUSPENSION/ DROPS 1 mg OPHTHALMIC NDA 18 sections
TobraDex HUMAN PRESCRIPTION DRUG LABEL 2 0065-0648 OINTMENT 1 mg OPHTHALMIC NDA 18 sections
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0078-0771 OINTMENT 1 mg OPHTHALMIC NDA 18 sections
CIPRODEX HUMAN PRESCRIPTION DRUG LABEL 2 0078-0799 SUSPENSION/ DROPS 1 mg AURICULAR (OTIC) NDA 28 sections
TobraDex HUMAN PRESCRIPTION DRUG LABEL 2 0078-0876 OINTMENT 1 mg OPHTHALMIC NDA 18 sections
TobraDex HUMAN PRESCRIPTION DRUG LABEL 2 0078-0953 SUSPENSION/ DROPS 1 mg OPHTHALMIC NDA 18 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0095-0087 TABLET 1.50 mg ORAL ANDA 23 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0095-0088 TABLET 1.50 mg ORAL ANDA 23 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0095-0089 TABLET 1.50 mg ORAL ANDA 23 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0121-0907 SOLUTION 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0121-1814 SOLUTION 1 mg ORAL ANDA 20 sections
Neomycin and Polymyxin B Sulfates and Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 3 0574-4160 OINTMENT 1 mg OPHTHALMIC ANDA 10 sections