prednisone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2253 53-03-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednisone anhydrous
  • prednisone
  • 1,2-dehydrocortisone
  • dehydrocortisone
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
  • Molecular weight: 358.43
  • Formula: C21H26O5
  • CLOGP: 1.66
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 91.67
  • ALOGS: -3.51
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.13 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 3 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 7.97 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.57 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.27 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 21, 1955 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1759.41 10.56 6344 522536 233871 45923311
Drug ineffective 1381.64 10.56 12678 516202 665160 45492022
Completed suicide 1333.12 10.56 80 528800 145840 46011342
Joint swelling 709.55 10.56 3733 525147 162340 45994842
Contraindicated product administered 663.40 10.56 2204 526676 77743 46079439
Death 657.97 10.56 1802 527078 333746 45823436
Toxicity to various agents 588.80 10.56 931 527949 210835 45946347
Systemic lupus erythematosus 564.98 10.56 1824 527056 63356 46093826
Arthralgia 558.10 10.56 6445 522435 358158 45799024
Treatment failure 555.84 10.56 2308 526572 90779 46066403
Intentional overdose 474.20 10.56 82 528798 64862 46092320
Pemphigus 465.25 10.56 1345 527535 43929 46113253
Overdose 452.82 10.56 299 528581 101680 46055502
Asthma 442.70 10.56 2132 526748 89410 46067772
Drug abuse 437.61 10.56 92 528788 63316 46093866
Colitis ulcerative 392.62 10.56 714 528166 17018 46140164
Post transplant lymphoproliferative disorder 373.00 10.56 326 528554 3530 46153652
Condition aggravated 360.76 10.56 4302 524578 240750 45916432
Therapeutic product effect incomplete 348.53 10.56 1779 527101 76374 46080808
Arthropathy 338.75 10.56 1871 527009 82829 46074353
Drug intolerance 329.99 10.56 2817 526063 144232 46012950
Pain 329.20 10.56 7384 521496 469564 45687618
Electrocardiogram QT prolonged 327.50 10.56 88 528792 51237 46105945
Product use in unapproved indication 324.97 10.56 1939 526941 88334 46068848
Therapeutic product effect decreased 322.59 10.56 1813 527067 80788 46076394
Musculoskeletal stiffness 302.55 10.56 2024 526856 95969 46061213
Drug interaction 291.63 10.56 1246 527634 201848 45955334
Bradycardia 290.70 10.56 197 528683 66101 46091081
Suicide attempt 289.89 10.56 130 528750 54906 46102276
Hyponatraemia 276.05 10.56 451 528429 100881 46056301
Loss of personal independence in daily activities 272.11 10.56 1326 527554 55857 46101325
Constipation 271.39 10.56 1034 527846 173063 45984119
Confusional state 264.78 10.56 926 527954 158966 45998216
Hand deformity 255.01 10.56 917 527963 33657 46123525
Infusion related reaction 254.48 10.56 1990 526890 99218 46057964
Acute kidney injury 246.90 10.56 1611 527269 234244 45922938
Depressed level of consciousness 244.89 10.56 116 528764 47453 46109729
Swelling 244.26 10.56 2317 526563 122194 46034988
Synovitis 243.35 10.56 1348 527532 59727 46097455
Glossodynia 234.56 10.56 1061 527819 43312 46113870
Cardio-respiratory arrest 226.96 10.56 206 528674 59663 46097519
Device expulsion 226.53 10.56 24 528856 27518 46129664
Seizure 226.36 10.56 680 528200 122374 46034808
Off label use 224.20 10.56 5758 523122 374083 45783099
Vomiting 224.06 10.56 3696 525184 449098 45708084
Histoplasmosis disseminated 223.14 10.56 146 528734 976 46156206
Cardiac arrest 216.10 10.56 436 528444 89963 46067219
Dizziness 212.81 10.56 2652 526228 337762 45819420
Cytomegalovirus infection 209.96 10.56 563 528317 17581 46139601
Osteoporosis 209.44 10.56 964 527916 39644 46117538
Wheezing 209.15 10.56 1173 527707 52213 46104969
Somnolence 190.22 10.56 1019 527861 155502 46001680
Decreased appetite 182.57 10.56 1365 527515 192471 45964711
Hypotension 178.24 10.56 1729 527151 230860 45926322
Loss of consciousness 177.64 10.56 629 528251 107609 46049573
Epstein-Barr virus infection 177.36 10.56 294 528586 6490 46150692
Rhabdomyolysis 173.91 10.56 132 528748 41777 46115405
Fall 173.64 10.56 2653 526227 326444 45830738
Obstructive airways disorder 171.43 10.56 432 528448 12980 46144202
Malignant neoplasm progression 169.36 10.56 297 528583 64629 46092553
Nausea 162.76 10.56 6261 522619 681193 45475989
Sinusitis 160.34 10.56 2207 526673 127561 46029621
Hallucination 160.08 10.56 198 528682 49753 46107429
Inflammation 158.59 10.56 1021 527859 47760 46109422
Agitation 157.14 10.56 240 528640 55175 46102007
Intentional self-injury 154.97 10.56 41 528839 24125 46133057
Hypoglycaemia 154.48 10.56 235 528645 54114 46103068
Hepatic function abnormal 153.93 10.56 100 528780 34321 46122861
Respiratory arrest 152.93 10.56 97 528783 33719 46123463
Aspergillus infection 151.95 10.56 277 528603 6613 46150569
Mobility decreased 149.21 10.56 1186 527694 59408 46097774
Peripheral swelling 149.09 10.56 2568 526312 155503 46001679
Cushingoid 147.26 10.56 259 528621 6007 46151175
Dehydration 147.08 10.56 1130 527750 158410 45998772
Drug withdrawal syndrome 145.26 10.56 64 528816 27320 46129862
Arthritis 144.72 10.56 1425 527455 75891 46081291
Productive cough 144.26 10.56 1027 527853 49688 46107494
Intentional product use issue 142.76 10.56 1056 527824 51724 46105458
Nocardiosis 141.13 10.56 129 528751 1488 46155694
Hyperkalaemia 137.74 10.56 226 528654 50483 46106699
Strongyloidiasis 137.47 10.56 98 528782 767 46156415
C-reactive protein abnormal 135.99 10.56 539 528341 20731 46136451
Pneumocystis jirovecii pneumonia 135.88 10.56 431 528449 14817 46142365
Abdominal discomfort 135.82 10.56 2437 526443 148728 46008454
Alopecia 135.05 10.56 2587 526293 159827 45997355
Forced expiratory volume decreased 134.51 10.56 222 528658 4882 46152300
Kidney transplant rejection 132.02 10.56 196 528684 3922 46153260
Transplant rejection 131.02 10.56 317 528563 9279 46147903
Sputum discoloured 128.67 10.56 377 528503 12401 46144781
Red blood cell sedimentation rate increased 128.26 10.56 557 528323 22332 46134850
Serotonin syndrome 126.28 10.56 58 528822 24162 46133020
Hypokalaemia 126.16 10.56 540 528340 87484 46069698
Anaemia 125.37 10.56 2090 526790 253689 45903493
Tremor 125.33 10.56 781 528099 114858 46042324
Suicidal ideation 124.66 10.56 284 528596 56098 46101084
Product use issue 121.51 10.56 1621 527259 93023 46064159
White blood cell count decreased 120.07 10.56 761 528119 111470 46045712
Pericarditis 119.66 10.56 563 528317 23364 46133818
Lactic acidosis 117.75 10.56 126 528754 33783 46123399
Red blood cell sedimentation rate abnormal 117.26 10.56 381 528499 13268 46143914
Dysarthria 116.65 10.56 152 528728 37346 46119836
Varicella zoster virus infection 116.05 10.56 138 528742 2205 46154977
Lethargy 115.38 10.56 255 528625 50916 46106266
Diffuse large B-cell lymphoma 115.17 10.56 226 528654 5712 46151470
Skin ulcer 114.00 10.56 693 528187 31765 46125417
Cerebrovascular accident 111.77 10.56 678 528202 100361 46056821
Dyskinesia 111.43 10.56 98 528782 28827 46128355
Smooth muscle cell neoplasm 111.33 10.56 73 528807 490 46156692
Nasopharyngitis 110.49 10.56 2400 526480 151598 46005584
Histoplasmosis 110.34 10.56 115 528765 1575 46155607
Wrong technique in product usage process 107.15 10.56 291 528589 54131 46103051
Wound 107.13 10.56 841 528039 41961 46115221
Blood pressure fluctuation 106.88 10.56 650 528230 29798 46127384
Poisoning 105.86 10.56 16 528864 13978 46143204
Anti-cyclic citrullinated peptide antibody positive 105.07 10.56 463 528417 18682 46138500
Sopor 104.13 10.56 47 528833 19781 46137401
Syncope 103.39 10.56 728 528152 104075 46053107
Product quality issue 103.37 10.56 152 528728 35496 46121686
Cardiac failure congestive 102.35 10.56 614 528266 91136 46066046
Sensitivity to weather change 102.25 10.56 206 528674 5310 46151872
Trichodysplasia spinulosa 100.72 10.56 62 528818 367 46156815
Palmar-plantar erythrodysaesthesia syndrome 100.53 10.56 53 528827 20398 46136784
Limb deformity 100.30 10.56 160 528720 3416 46153766
Haemophagocytic lymphohistiocytosis 98.68 10.56 261 528619 8081 46149101
Rheumatoid nodule 98.48 10.56 274 528606 8746 46148436
Polyomavirus-associated nephropathy 98.37 10.56 102 528778 1388 46155794
Metabolic acidosis 97.88 10.56 181 528699 38599 46118583
Aggression 97.78 10.56 69 528811 22675 46134507
Unresponsive to stimuli 96.45 10.56 134 528746 32040 46125142
Neuroleptic malignant syndrome 95.95 10.56 8 528872 11114 46146068
Cognitive disorder 95.91 10.56 169 528711 36714 46120468
Depression 95.84 10.56 1353 527527 168751 45988431
Infection 92.95 10.56 2073 526807 131519 46025663
Cytomegalovirus viraemia 92.45 10.56 175 528705 4303 46152879
Circulatory collapse 92.44 10.56 66 528814 21558 46135624
Balance disorder 92.32 10.56 396 528484 64125 46093057
Disease recurrence 91.91 10.56 434 528446 18037 46139145
International normalised ratio increased 91.31 10.56 252 528628 46631 46110551
Cough 90.99 10.56 3325 525555 226924 45930258
Septic shock 90.46 10.56 1029 527851 56864 46100318
Product substitution issue 88.21 10.56 30 528850 15001 46142181
Sedation 87.80 10.56 78 528802 22832 46134350
Blood pressure systolic increased 87.17 10.56 592 528288 28195 46128987
Multiple sclerosis relapse 86.92 10.56 220 528660 41905 46115277
Neutrophil count decreased 85.63 10.56 232 528648 43194 46113988
Disturbance in attention 85.38 10.56 141 528739 31419 46125763
Intentional product misuse 84.74 10.56 263 528617 46865 46110317
Gastrointestinal haemorrhage 83.57 10.56 523 528357 76850 46080332
Knee arthroplasty 83.56 10.56 506 528374 23159 46134023
Cardiac failure 83.49 10.56 546 528334 79402 46077780
Orthostatic hypotension 81.91 10.56 95 528785 24563 46132619
Haematemesis 81.42 10.56 125 528755 28681 46128501
Phaeohyphomycosis 80.87 10.56 44 528836 198 46156984
Herpes zoster 79.18 10.56 1143 527737 66729 46090453
Altered state of consciousness 78.59 10.56 89 528791 23259 46133923
BK virus infection 77.90 10.56 126 528754 2723 46154459
Blood alkaline phosphatase increased 77.81 10.56 212 528668 39397 46117785
Dysgeusia 77.11 10.56 220 528660 40271 46116911
Crohn's disease 76.22 10.56 208 528672 6563 46150619
Myocardial infarction 75.82 10.56 722 528158 96806 46060376
Diffuse large B-cell lymphoma recurrent 75.75 10.56 89 528791 1403 46155779
Adrenal insufficiency 74.77 10.56 321 528559 12803 46144379
Cryptococcosis 74.42 10.56 68 528812 784 46156398
Hyperhidrosis 74.26 10.56 650 528230 88658 46068524
Anxiety 74.03 10.56 1535 527345 180422 45976760
Weight increased 73.90 10.56 2411 526469 162062 45995120
Diarrhoea 73.84 10.56 5402 523478 554200 45602982
Contrast media allergy 73.17 10.56 96 528784 1703 46155479
Cytomegalovirus colitis 72.77 10.56 94 528786 1641 46155541
West Nile viral infection 72.75 10.56 49 528831 346 46156836
Amnesia 72.28 10.56 236 528644 41395 46115787
Product dose omission issue 72.04 10.56 1410 527470 167110 45990072
Complications of transplanted kidney 71.53 10.56 107 528773 2156 46155026
Brain abscess 70.50 10.56 92 528788 1623 46155559
Gamma-glutamyltransferase increased 70.05 10.56 160 528720 31580 46125602
Metastases to bone 70.02 10.56 57 528823 17419 46139763
Faecal calprotectin increased 69.80 10.56 94 528786 1712 46155470
Epidural lipomatosis 69.08 10.56 31 528849 82 46157100
Panniculitis 69.04 10.56 180 528700 5524 46151658
Extrapyramidal disorder 68.76 10.56 21 528859 11247 46145935
Respiratory depression 68.34 10.56 23 528857 11577 46145605
Abnormal behaviour 67.95 10.56 83 528797 20975 46136207
Sleep disorder due to a general medical condition 67.65 10.56 133 528747 3366 46153816
Melaena 67.13 10.56 133 528747 27639 46129543
Disorientation 67.10 10.56 205 528675 36713 46120469
Therapeutic response decreased 67.00 10.56 766 528114 42379 46114803
Schizophrenia 66.67 10.56 9 528871 8559 46148623
Hip arthroplasty 66.34 10.56 391 528489 17721 46139461
Metastases to liver 65.54 10.56 75 528805 19510 46137672
Bone density decreased 65.48 10.56 251 528629 9501 46147681
Dystonia 65.14 10.56 23 528857 11234 46145948
Rheumatoid factor positive 65.09 10.56 426 528454 20035 46137147
Respiratory tract congestion 65.04 10.56 302 528578 12462 46144720
Polyarthritis 64.90 10.56 192 528688 6350 46150832
Therapy partial responder 64.27 10.56 155 528725 4527 46152655
Muscle spasms 64.18 10.56 994 527886 122119 46035063
Renal failure 64.12 10.56 903 527977 112691 46044491
Acquired haemophilia 63.76 10.56 65 528815 866 46156316
Diabetes mellitus 63.59 10.56 856 528024 49209 46107973
Candida infection 63.00 10.56 450 528430 21790 46135392
Musculoskeletal pain 62.69 10.56 1130 527750 68998 46088184
Epilepsy 62.42 10.56 108 528772 23630 46133552
Device dislocation 62.20 10.56 94 528786 21708 46135474
Obliterative bronchiolitis 62.02 10.56 88 528792 1687 46155495
Torsade de pointes 61.98 10.56 30 528850 12124 46145058
Platelet count decreased 61.96 10.56 780 528100 99244 46057938
Transient ischaemic attack 61.89 10.56 196 528684 34707 46122475
Delusion 61.17 10.56 25 528855 11163 46146019
Medication error 61.05 10.56 165 528715 30746 46126436
Breast cancer metastatic 60.79 10.56 40 528840 13638 46143544
Blood creatine phosphokinase increased 60.18 10.56 141 528739 27583 46129599
Blood parathyroid hormone decreased 60.10 10.56 145 528735 4236 46152946
Blood count abnormal 59.81 10.56 377 528503 17501 46139681
Joint effusion 59.79 10.56 282 528598 11713 46145469
Cerebral haemorrhage 59.44 10.56 147 528733 28224 46128958
Restlessness 59.35 10.56 125 528755 25399 46131783
Deformity 59.14 10.56 199 528681 7058 46150124
Granuloma skin 58.92 10.56 125 528755 3345 46153837
Product prescribing error 58.59 10.56 85 528795 19962 46137220
Lupus nephritis 58.26 10.56 97 528783 2149 46155033
Alanine aminotransferase increased 58.11 10.56 681 528199 87770 46069412
Aspartate aminotransferase increased 58.06 10.56 590 528290 78110 46079072
Multiple sclerosis 57.99 10.56 121 528759 24670 46132512
Ventricular tachycardia 57.84 10.56 64 528816 16903 46140279
Sarcoidosis 57.59 10.56 158 528722 5001 46152181
Central nervous system lymphoma 57.45 10.56 71 528809 1183 46155999
Drug specific antibody 57.18 10.56 71 528809 1189 46155993
Mycobacterial infection 57.12 10.56 81 528799 1552 46155630
Withdrawal syndrome 56.92 10.56 73 528807 18061 46139121
Tenosynovitis 56.82 10.56 201 528679 7314 46149868
Body height below normal 56.77 10.56 86 528794 1753 46155429
Muscle rigidity 56.54 10.56 21 528859 9940 46147242
Tardive dyskinesia 56.20 10.56 9 528871 7534 46149648
Tachycardia 55.49 10.56 794 528086 98828 46058354
Arrhythmia 55.43 10.56 205 528675 34636 46122546
Mycobacterium avium complex infection 55.30 10.56 104 528776 2544 46154638
Disability 55.12 10.56 245 528635 9922 46147260
Vaginal haemorrhage 54.95 10.56 131 528749 25473 46131709
Palpitations 54.91 10.56 754 528126 94505 46062677
Ascites 54.52 10.56 221 528659 36363 46120819
Human antichimeric antibody positive 54.47 10.56 73 528807 1323 46155859
Neuropathy peripheral 54.36 10.56 714 528166 90179 46067003
Coma 54.30 10.56 412 528468 57937 46099245
Plasma cell myeloma 54.26 10.56 289 528591 44189 46112993
Posterior reversible encephalopathy syndrome 54.26 10.56 325 528555 14816 46142366
Miosis 54.23 10.56 6 528874 6651 46150531
Jaundice 53.98 10.56 158 528722 28687 46128495
Juvenile idiopathic arthritis 53.75 10.56 134 528746 3998 46153184
Impaired work ability 53.74 10.56 284 528596 12352 46144830
Akathisia 53.60 10.56 11 528869 7703 46149479
Infection reactivation 53.41 10.56 55 528825 742 46156440
Acute myocardial infarction 53.34 10.56 184 528696 31740 46125442
Joint stiffness 53.32 10.56 505 528375 26603 46130579
Psoriatic arthropathy 52.99 10.56 638 528242 35741 46121441
Biopsy lung abnormal 52.69 10.56 28 528852 119 46157063
Foot deformity 52.68 10.56 327 528553 15098 46142084
Chronic allograft nephropathy 52.62 10.56 50 528830 608 46156574
Blood bilirubin increased 52.53 10.56 204 528676 33980 46123202
Cataract 52.24 10.56 763 528117 44652 46112530
Hepatic enzyme increased 51.85 10.56 1253 527627 80534 46076648
Pre-existing disease 51.73 10.56 29 528851 140 46157042
Ulcer 51.66 10.56 356 528524 17036 46140146
Nightmare 50.88 10.56 68 528812 16530 46140652
Urinary retention 50.80 10.56 140 528740 25921 46131261
Diabetic ketoacidosis 50.53 10.56 80 528800 18130 46139052
Maternal exposure during pregnancy 50.43 10.56 1520 527360 101029 46056153
Sinus bradycardia 50.36 10.56 49 528831 13733 46143449
Stevens-Johnson syndrome 50.15 10.56 119 528761 23178 46134004
Toxoplasmosis 50.03 10.56 70 528810 1324 46155858
Lupus-like syndrome 49.51 10.56 198 528682 7646 46149536
Respiratory disorder 49.50 10.56 500 528380 26800 46130382
Accidental overdose 49.45 10.56 95 528785 19971 46137211
Cytomegalovirus gastrointestinal infection 49.28 10.56 34 528846 251 46156931
Ventricular fibrillation 49.25 10.56 35 528845 11461 46145721
Delayed graft function 49.14 10.56 58 528822 919 46156263
Visceral leishmaniasis 49.10 10.56 41 528839 415 46156767
Liver transplant rejection 48.97 10.56 69 528811 1314 46155868
Abnormal dreams 48.55 10.56 28 528852 10251 46146931
Hypothermia 48.48 10.56 40 528840 12143 46145039
Osteoporotic fracture 48.45 10.56 106 528774 2899 46154283
Steroid diabetes 48.35 10.56 47 528833 589 46156593
Steroid dependence 48.03 10.56 24 528856 87 46157095
Ill-defined disorder 48.00 10.56 490 528390 26337 46130845
Bronchiectasis 47.89 10.56 221 528659 9095 46148087
Cerebral infarction 47.45 10.56 123 528757 23243 46133939
Full blood count decreased 47.38 10.56 114 528766 22097 46135085
Metastases to central nervous system 46.98 10.56 35 528845 11186 46145996
Breast cancer 46.93 10.56 312 528568 45206 46111976
Product administration error 46.93 10.56 95 528785 19586 46137596
Myoclonus 46.91 10.56 56 528824 14296 46142886
Accidental exposure to product 46.73 10.56 106 528774 20975 46136207
Mucormycosis 46.61 10.56 89 528791 2203 46154979
Subdural haematoma 46.58 10.56 47 528833 12950 46144232
Blood pressure diastolic abnormal 46.44 10.56 167 528713 6127 46151055
Hallucination, visual 46.37 10.56 82 528798 17791 46139391
COVID-19 45.93 10.56 364 528516 18211 46138971
Dust allergy 45.84 10.56 42 528838 486 46156696
Hypomagnesaemia 45.81 10.56 116 528764 22094 46135088
Immobile 45.52 10.56 135 528745 4471 46152711
Blood immunoglobulin E increased 45.23 10.56 76 528804 1697 46155485
Device difficult to use 45.22 10.56 17 528863 7987 46149195
Eosinophilic bronchitis 45.22 10.56 33 528847 269 46156913
Lower respiratory tract infection 45.18 10.56 876 528004 54213 46102969
Oedema peripheral 45.14 10.56 1421 527459 158285 45998897
Atrial fibrillation 45.06 10.56 864 528016 102726 46054456
Epistaxis 45.02 10.56 488 528392 63817 46093365
Memory impairment 44.61 10.56 612 528268 76725 46080457
Generalised tonic-clonic seizure 44.19 10.56 158 528722 26964 46130218
Pruritus allergic 44.17 10.56 57 528823 994 46156188
Mucocutaneous leishmaniasis 44.17 10.56 34 528846 303 46156879
Mydriasis 44.08 10.56 33 528847 10520 46146662
Epidermodysplasia verruciformis 44.07 10.56 19 528861 44 46157138
Vasculitis 43.94 10.56 286 528594 13425 46143757
Swollen tongue 43.93 10.56 176 528704 29056 46128126
Delirium 43.70 10.56 245 528635 36983 46120199
Flushing 43.00 10.56 496 528384 64118 46093064
Renal graft infection 42.88 10.56 23 528857 100 46157082
Nasal polyps 42.72 10.56 84 528796 2126 46155056
Incorrect product administration duration 42.57 10.56 28 528852 9549 46147633
Human herpesvirus 8 infection 42.30 10.56 27 528853 172 46157010
Rheumatoid lung 42.21 10.56 72 528808 1628 46155554
Coccidioidomycosis 42.08 10.56 51 528829 832 46156350
Drug reaction with eosinophilia and systemic symptoms 41.86 10.56 182 528698 29366 46127816
Wrist surgery 41.67 10.56 48 528832 740 46156442
Hypogammaglobulinaemia 41.59 10.56 146 528734 5292 46151890
Coronary artery disease 41.34 10.56 219 528661 33533 46123649
Salivary hypersecretion 41.20 10.56 11 528869 6434 46150748
Immunosuppressant drug level increased 41.19 10.56 105 528775 3177 46154005
Haematoma 41.19 10.56 203 528677 31669 46125513
Eye infection toxoplasmal 41.11 10.56 31 528849 267 46156915
Granuloma 41.09 10.56 115 528765 3683 46153499
Heart transplant rejection 41.05 10.56 38 528842 446 46156736
Discomfort 40.99 10.56 750 528130 45920 46111262
Loose body in joint 40.87 10.56 55 528825 1001 46156181
Musculoskeletal disorder 40.86 10.56 309 528571 15236 46141946
Psychotic disorder 40.83 10.56 126 528754 22495 46134687
Hallucination, auditory 40.76 10.56 37 528843 10719 46146463
Neutropenia 40.75 10.56 1273 527607 141931 46015251
Scleritis 40.61 10.56 97 528783 2815 46154367
Secretion discharge 40.44 10.56 209 528671 9010 46148172
Sciatica 40.27 10.56 360 528520 18660 46138522
Heart rate increased 40.17 10.56 1121 527759 73670 46083512
Uterine perforation 40.12 10.56 16 528864 7251 46149931
Wheelchair user 40.11 10.56 118 528762 3890 46153292
Dementia 40.10 10.56 67 528813 14863 46142319
American trypanosomiasis 40.01 10.56 18 528862 48 46157134
Meningitis cryptococcal 39.93 10.56 58 528822 1137 46156045
Paraesthesia 39.76 10.56 1019 527861 116418 46040764
Vision blurred 39.69 10.56 649 528231 79059 46078123
Hypocalcaemia 39.16 10.56 163 528717 26622 46130560
Bedridden 39.05 10.56 206 528674 8953 46148229
Product adhesion issue 39.04 10.56 5 528875 4950 46152232
Finger deformity 38.97 10.56 138 528742 5024 46152158
Arthrodesis 38.96 10.56 82 528798 2182 46155000
Influenza 38.86 10.56 1304 527576 87966 46069216
Mucous stools 38.85 10.56 87 528793 2418 46154764
Symptom masked 38.82 10.56 40 528840 540 46156642
Hypersensitivity 38.71 10.56 2078 526802 148243 46008939
Lennox-Gastaut syndrome 38.63 10.56 29 528851 248 46156934
General physical health deterioration 38.54 10.56 1007 527873 114762 46042420
Escherichia bacteraemia 38.54 10.56 92 528788 2669 46154513
Chest pain 38.50 10.56 1619 527261 174705 45982477
Poisoning deliberate 38.28 10.56 21 528859 7905 46149277
Neutropenic sepsis 38.28 10.56 50 528830 12274 46144908
Rebound effect 38.21 10.56 91 528789 2636 46154546
Lung disorder 38.06 10.56 696 528184 42608 46114574
Blood glucose increased 37.99 10.56 580 528300 71433 46085749
Angioedema 37.93 10.56 275 528605 39067 46118115
Lung transplant rejection 37.60 10.56 45 528835 724 46156458
Blood pressure decreased 37.56 10.56 440 528440 56719 46100463
Pulmonary fibrosis 37.40 10.56 370 528510 19722 46137460
Complication associated with device 37.27 10.56 74 528806 15367 46141815
Blood calcium decreased 37.07 10.56 76 528804 15597 46141585
Parkinsonism 37.04 10.56 22 528858 7926 46149256
Gastrointestinal disorder 36.93 10.56 910 527970 58666 46098516
Blood urea increased 36.62 10.56 155 528725 25197 46131985
Liver disorder 36.56 10.56 259 528621 36987 46120195
Tuberculin test positive 36.56 10.56 95 528785 2909 46154273
Clostridium difficile infection 36.45 10.56 440 528440 24663 46132519
Hypertonia 36.45 10.56 4 528876 4462 46152720
Temporal lobe epilepsy 36.28 10.56 32 528848 351 46156831
Blood pressure systolic abnormal 36.22 10.56 141 528739 5376 46151806
Bronchitis 36.01 10.56 1506 527374 104473 46052709
Pulmonary toxicity 35.89 10.56 126 528754 4567 46152615
Fear of injection 35.84 10.56 116 528764 4031 46153151
Total lung capacity increased 35.74 10.56 44 528836 730 46156452
Dermatomyositis 35.71 10.56 74 528806 1947 46155235
Pseudohyponatraemia 35.67 10.56 17 528863 54 46157128
Skin necrosis 35.65 10.56 192 528688 8412 46148770
Unintended pregnancy 35.54 10.56 10 528870 5650 46151532
Genital haemorrhage 35.37 10.56 15 528865 6551 46150631
Haemoglobin decreased 35.31 10.56 1152 527728 127797 46029385
Listeriosis 35.14 10.56 54 528826 1115 46156067
Depressed mood 35.05 10.56 227 528653 33092 46124090
Joint range of motion decreased 35.03 10.56 292 528588 14832 46142350
Mental status changes 34.93 10.56 270 528610 37818 46119364
Joint injury 34.92 10.56 352 528528 18857 46138325
Unintentional medical device removal 34.91 10.56 5 528875 4548 46152634
Metastases to lung 34.68 10.56 42 528838 10654 46146528
Inappropriate antidiuretic hormone secretion 34.54 10.56 67 528813 14035 46143147
Wrist deformity 34.53 10.56 62 528818 1462 46155720
Pain in extremity 34.34 10.56 3389 525491 255291 45901891
Therapy responder 34.31 10.56 30 528850 325 46156857
Mental impairment 34.29 10.56 55 528825 12401 46144781
Therapy non-responder 34.29 10.56 656 528224 40496 46116686
Frequent bowel movements 34.28 10.56 253 528627 12379 46144803
Therapeutic response shortened 34.24 10.56 133 528747 5066 46152116
Epstein-Barr viraemia 34.20 10.56 42 528838 695 46156487
Fluid retention 33.90 10.56 392 528488 50654 46106528
Device use error 33.78 10.56 8 528872 5073 46152109
Pre-engraftment immune reaction 33.56 10.56 25 528855 211 46156971
Adjustment disorder with depressed mood 33.35 10.56 52 528828 1088 46156094
Substance abuse 33.33 10.56 4 528876 4163 46153019
No adverse event 33.13 10.56 239 528641 33992 46123190
Drug level below therapeutic 32.98 10.56 94 528786 3043 46154139
Hepatosplenic T-cell lymphoma 32.78 10.56 38 528842 590 46156592
Hypophagia 32.72 10.56 196 528684 29110 46128072
Oropharyngeal pain 32.68 10.56 1085 527795 73083 46084099
Uveitis 32.59 10.56 188 528692 8453 46148729
Foetal exposure during pregnancy 32.58 10.56 209 528671 30538 46126644
Restless legs syndrome 32.48 10.56 83 528797 15760 46141422
Complication of device insertion 32.44 10.56 8 528872 4936 46152246
Pleural mesothelioma malignant 32.33 10.56 15 528865 44 46157138
Herpes simplex hepatitis 32.20 10.56 27 528853 275 46156907
Pyoderma gangrenosum 32.13 10.56 85 528795 2632 46154550
Breath sounds abnormal 32.11 10.56 174 528706 7641 46149541
Epstein-Barr virus associated lymphoproliferative disorder 32.03 10.56 59 528821 1420 46155762
Renal impairment 31.82 10.56 622 528258 73750 46083432
Joint laxity 31.62 10.56 72 528808 2024 46155158
Hepatic failure 31.53 10.56 235 528645 33181 46124001
Poor venous access 31.49 10.56 181 528699 8127 46149055
Acanthamoeba infection 31.47 10.56 14 528866 36 46157146
Coordination abnormal 31.43 10.56 47 528833 10902 46146280
Fear 31.42 10.56 87 528793 16085 46141097
Interstitial lung disease 31.36 10.56 817 528063 53132 46104050
Human ehrlichiosis 31.17 10.56 23 528857 191 46156991
Focal segmental glomerulosclerosis 31.17 10.56 57 528823 1364 46155818
Ketoacidosis 31.14 10.56 4 528876 3951 46153231
Treatment noncompliance 31.04 10.56 203 528677 29528 46127654
Haematotoxicity 30.99 10.56 158 528722 6775 46150407
Epstein-Barr virus associated lymphoma 30.92 10.56 26 528854 266 46156916
Colectomy 30.88 10.56 71 528809 2009 46155173
Immunosuppression 30.82 10.56 167 528713 7333 46149849
Urticaria 30.79 10.56 1632 527248 116260 46040922
Urinary incontinence 30.71 10.56 193 528687 28337 46128845
Multifocal micronodular pneumocyte hyperplasia 30.66 10.56 16 528864 65 46157117
Bronchial polyp 30.66 10.56 16 528864 65 46157117
Myalgia 30.60 10.56 1113 527767 121975 46035207
Polymyalgia rheumatica 30.52 10.56 76 528804 2266 46154916
Liver function test abnormal 30.48 10.56 358 528522 46129 46111053
Lower respiratory tract congestion 30.41 10.56 66 528814 1795 46155387
Upper gastrointestinal haemorrhage 30.37 10.56 93 528787 16645 46140537
Bacillary angiomatosis 30.29 10.56 16 528864 67 46157115
Secondary immunodeficiency 30.25 10.56 46 528834 941 46156241
Localised infection 30.24 10.56 407 528473 23394 46133788
Application site erythema 30.18 10.56 9 528871 4895 46152287
Dry mouth 30.13 10.56 439 528441 54487 46102695
Electrocardiogram QRS complex prolonged 30.08 10.56 12 528868 5437 46151745
Irritability 30.04 10.56 198 528682 28748 46128434
Cutaneous calcification 30.02 10.56 17 528863 84 46157098
Labelled drug-drug interaction medication error 29.99 10.56 35 528845 9026 46148156
Rhinitis 29.81 10.56 172 528708 7734 46149448
Synovial cyst 29.81 10.56 163 528717 7183 46149999
Diffuse large B-cell lymphoma refractory 29.64 10.56 45 528835 919 46156263
Caesarean section 29.60 10.56 93 528787 16510 46140672
Galactorrhoea 29.52 10.56 4 528876 3793 46153389
Neoplasm progression 29.50 10.56 179 528701 26504 46130678
Skin exfoliation 29.50 10.56 235 528645 32703 46124479
Hypernatraemia 29.44 10.56 18 528862 6383 46150799
Arthritis bacterial 29.43 10.56 136 528744 5600 46151582
B-cell lymphoma recurrent 29.29 10.56 30 528850 402 46156780
Peritonitis bacterial 29.10 10.56 33 528847 8620 46148562
Atrioventricular block first degree 29.00 10.56 17 528863 6169 46151013
Infective tenosynovitis 29.00 10.56 23 528857 215 46156967
Faecaloma 28.98 10.56 27 528853 7725 46149457
Myopathy 28.92 10.56 186 528694 8695 46148487
Malacoplakia 28.91 10.56 16 528864 75 46157107
Ischaemic stroke 28.88 10.56 95 528785 16627 46140555
Blood glucose decreased 28.86 10.56 113 528767 18779 46138403
Necrotising retinitis 28.80 10.56 25 528855 268 46156914
Blood pressure increased 28.72 10.56 1731 527149 124935 46032247
Hepatitis B reactivation 28.61 10.56 57 528823 1457 46155725
Joint destruction 28.58 10.56 88 528792 2976 46154206
Panic attack 28.48 10.56 125 528755 20117 46137065
Creatinine renal clearance decreased 28.44 10.56 22 528858 6898 46150284
Graft loss 28.30 10.56 28 528852 359 46156823
Complement factor C3 decreased 28.12 10.56 19 528861 135 46157047
Renal transplant failure 28.10 10.56 36 528844 623 46156559
Polyomavirus viraemia 27.94 10.56 28 528852 365 46156817
Jaundice cholestatic 27.88 10.56 11 528869 5018 46152164
Bone swelling 27.88 10.56 50 528830 1178 46156004
Glomerulosclerosis 27.83 10.56 26 528854 309 46156873
Drug tolerance decreased 27.74 10.56 87 528793 2972 46154210
Calciphylaxis 27.67 10.56 77 528803 2458 46154724
Disease progression 27.58 10.56 805 528075 90495 46066687
Tuberculosis 27.52 10.56 205 528675 10060 46147122
Abdominal pain upper 27.48 10.56 1355 527525 143950 46013232
Renal tubular atrophy 27.45 10.56 32 528848 500 46156682
B-cell lymphoma 27.44 10.56 91 528789 3203 46153979
Anaphylactic shock 27.44 10.56 127 528753 20147 46137035
Oral herpes 27.34 10.56 338 528542 19052 46138130
Periostitis 27.12 10.56 22 528858 213 46156969
Rhinorrhoea 26.88 10.56 719 528161 46946 46110236
C-reactive protein increased 26.82 10.56 861 528019 57729 46099453
Complications of transplanted lung 26.80 10.56 22 528858 217 46156965
Speech disorder 26.72 10.56 271 528609 35896 46121286
Orf 26.57 10.56 11 528869 22 46157160
Cutaneous leishmaniasis 26.51 10.56 15 528865 74 46157108
Complement factor C4 decreased 26.51 10.56 15 528865 74 46157108
Microsporidia infection 26.48 10.56 22 528858 221 46156961
Pregnancy with contraceptive device 26.40 10.56 9 528871 4494 46152688
Human polyomavirus infection 26.34 10.56 21 528859 198 46156984
Therapeutic reaction time decreased 26.21 10.56 45 528835 1023 46156159
Endocarditis bacterial 26.16 10.56 33 528847 562 46156620
Drug screen positive 26.12 10.56 6 528874 3885 46153297
Clonus 26.01 10.56 7 528873 4073 46153109
Aphasia 25.96 10.56 203 528677 28364 46128818
Ventricular extrasystoles 25.87 10.56 54 528826 11009 46146173
Duodenal ulcer perforation 25.83 10.56 175 528705 8327 46148855
Encephalitis viral 25.72 10.56 57 528823 1573 46155609
Polyp 25.70 10.56 121 528759 5022 46152160
Immunodeficiency 25.69 10.56 244 528636 12862 46144320
Cholecystitis chronic 25.61 10.56 50 528830 10449 46146733
Nodule 25.56 10.56 280 528600 15325 46141857
Angiocentric lymphoma 25.53 10.56 29 528851 440 46156742
Elbow deformity 25.40 10.56 51 528829 1311 46155871
Ear pain 25.33 10.56 371 528509 21721 46135461
Parvovirus B19 infection 25.30 10.56 25 528855 320 46156862
Erythropoiesis abnormal 25.26 10.56 22 528858 237 46156945
Haemolytic uraemic syndrome 25.14 10.56 74 528806 2440 46154742
Necrotising herpetic retinopathy 25.07 10.56 14 528866 67 46157115
Oral pain 25.04 10.56 171 528709 24626 46132556
Bronchopulmonary aspergillosis 25.03 10.56 158 528722 7338 46149844
Herpes virus infection 25.00 10.56 114 528766 4668 46152514
Nasal congestion 24.96 10.56 718 528162 47395 46109787
Alternaria infection 24.83 10.56 18 528862 145 46157037
Mycobacterium chelonae infection 24.74 10.56 28 528852 423 46156759
Erythema multiforme 24.74 10.56 45 528835 9659 46147523
Blood pressure diastolic decreased 24.68 10.56 258 528622 13953 46143229
Atrioventricular block complete 24.67 10.56 30 528850 7597 46149585
Glycosylated haemoglobin increased 24.67 10.56 54 528826 10822 46146360
Intestinal resection 24.60 10.56 68 528812 2162 46155020
Sensory disturbance 24.58 10.56 65 528815 12202 46144980
Antinuclear antibody positive 24.58 10.56 138 528742 6142 46151040
Disability assessment scale score increased 24.56 10.56 68 528812 2164 46155018
Steroid withdrawal syndrome 24.45 10.56 29 528851 462 46156720
Status epilepticus 24.43 10.56 79 528801 13900 46143282
Injection site bruising 24.43 10.56 552 528328 35084 46122098
Emphysema 24.38 10.56 181 528699 8873 46148309
Isosporiasis 24.33 10.56 12 528868 42 46157140
Colitis microscopic 24.31 10.56 23 528857 6533 46150649
Joint warmth 24.30 10.56 48 528832 1219 46155963
Insomnia 24.25 10.56 1576 527304 163348 45993834
Bradyphrenia 24.12 10.56 21 528859 6209 46150973
Tractional retinal detachment 24.12 10.56 12 528868 43 46157139
Abortion incomplete 24.08 10.56 4 528876 3260 46153922
Escherichia infection 24.07 10.56 207 528673 10610 46146572
New onset diabetes after transplantation 24.02 10.56 11 528869 31 46157151
Immune system disorder 23.95 10.56 164 528716 7831 46149351
Hepatitis B 23.94 10.56 94 528786 3599 46153583
Bone pain 23.93 10.56 380 528500 46510 46110672
Disseminated varicella zoster virus infection 23.88 10.56 35 528845 692 46156490
JC virus infection 23.87 10.56 56 528824 1606 46155576
Toxic epidermal necrolysis 23.83 10.56 151 528729 22127 46135055
Product preparation error 23.81 10.56 8 528872 4031 46153151
Hot flush 23.80 10.56 348 528532 43169 46114013
Device breakage 23.78 10.56 46 528834 9646 46147536
Psychomotor retardation 23.77 10.56 4 528876 3229 46153953
Nerve injury 23.65 10.56 159 528721 7546 46149636
Human herpesvirus 6 infection 23.64 10.56 71 528809 2368 46154814
Acute generalised exanthematous pustulosis 23.64 10.56 44 528836 9361 46147821
Birdshot chorioretinopathy 23.55 10.56 14 528866 77 46157105
Sinus tachycardia 23.53 10.56 146 528734 21503 46135679
Humoral immune defect 23.48 10.56 13 528867 61 46157121
Disseminated cytomegaloviral infection 23.44 10.56 15 528865 96 46157086
Shock 23.40 10.56 148 528732 21697 46135485
Myocardial ischaemia 23.02 10.56 71 528809 12678 46144504
Hyperprolactinaemia 23.00 10.56 3 528877 2929 46154253
Peak expiratory flow rate decreased 22.96 10.56 32 528848 603 46156579
Serum sickness 22.96 10.56 71 528809 2407 46154775
Cerebral aspergillosis 22.95 10.56 24 528856 330 46156852
Injection site hypersensitivity 22.92 10.56 52 528828 1458 46155724
Neuroendocrine carcinoma of the skin 22.91 10.56 27 528853 427 46156755
Exposure during pregnancy 22.89 10.56 997 527883 107215 46049967
Thinking abnormal 22.87 10.56 48 528832 9766 46147416
Ileostomy 22.80 10.56 44 528836 1098 46156084
Ataxia 22.79 10.56 81 528799 13849 46143333
Inflammatory bowel disease 22.77 10.56 84 528796 3121 46154061
Renal disorder 22.71 10.56 193 528687 26493 46130689
Kidney fibrosis 22.67 10.56 50 528830 1375 46155807
Ureaplasma infection 22.58 10.56 27 528853 434 46156748
Sudden death 22.55 10.56 46 528834 9458 46147724
Cardiac disorder 22.53 10.56 355 528525 43503 46113679
Bronchopleural fistula 22.49 10.56 20 528860 222 46156960
Epstein Barr virus positive mucocutaneous ulcer 22.49 10.56 20 528860 222 46156960
Cerebral toxoplasmosis 22.48 10.56 34 528846 692 46156490
Lung diffusion test decreased 22.46 10.56 32 528848 616 46156566
Product physical issue 22.46 10.56 14 528866 4913 46152269
Urate nephropathy 22.38 10.56 15 528865 105 46157077
International normalised ratio fluctuation 22.36 10.56 65 528815 2128 46155054
Blood sodium decreased 22.35 10.56 149 528731 21577 46135605
Chronic kidney disease 22.30 10.56 327 528553 40544 46116638
Blood creatinine increased 22.24 10.56 677 528203 75726 46081456
Complication of device removal 22.23 10.56 6 528874 3484 46153698
Central nervous system vasculitis 22.16 10.56 39 528841 905 46156277
Herpes simplex 22.13 10.56 149 528731 7074 46150108
Pyomyositis 22.13 10.56 24 528856 345 46156837
Skin plaque 22.04 10.56 127 528753 5708 46151474
Perfume sensitivity 21.97 10.56 30 528850 554 46156628
Renal injury 21.95 10.56 47 528833 9494 46147688
Pneumonia cytomegaloviral 21.85 10.56 60 528820 1900 46155282
Pulmonary embolism 21.83 10.56 1006 527874 107579 46049603
Coma scale abnormal 21.76 10.56 15 528865 4991 46152191
Human bocavirus infection 21.67 10.56 23 528857 322 46156860
Toxic skin eruption 21.65 10.56 70 528810 12317 46144865
Infection parasitic 21.59 10.56 22 528858 293 46156889
Cerebral venous sinus thrombosis 21.48 10.56 57 528823 1768 46155414
Ankle deformity 21.48 10.56 25 528855 390 46156792
Respiratory tract infection 21.41 10.56 467 528413 29505 46127677
Hypertrophic osteoarthropathy 21.40 10.56 10 528870 30 46157152
Klebsiella infection 21.37 10.56 139 528741 6523 46150659
Lymphoproliferative disorder 21.22 10.56 73 528807 2619 46154563
Progressive multifocal leukoencephalopathy 21.15 10.56 209 528671 11137 46146045
Temperature regulation disorder 20.98 10.56 6 528874 3354 46153828
Lung hernia 20.95 10.56 6 528874 0 46157182
Granulomatosis with polyangiitis 20.93 10.56 56 528824 1746 46155436
Neck deformity 20.91 10.56 57 528823 1797 46155385
Limb mass 20.87 10.56 69 528811 2425 46154757
Bronchial disorder 20.81 10.56 40 528840 995 46156187
Incorrect route of product administration 20.79 10.56 105 528775 16278 46140904
Psychomotor hyperactivity 20.77 10.56 49 528831 9564 46147618
Device occlusion 20.74 10.56 22 528858 5923 46151259
Prosthesis user 20.72 10.56 13 528867 80 46157102
Somnambulism 20.72 10.56 16 528864 5021 46152161
Porokeratosis 20.68 10.56 15 528865 121 46157061
Epstein-Barr virus test positive 20.63 10.56 29 528851 551 46156631
Dysphagia 20.60 10.56 693 528187 76619 46080563
Vertigo 20.56 10.56 441 528439 51607 46105575
Peritoneal dialysis complication 20.56 10.56 3 528877 2691 46154491
Growth retardation 20.56 10.56 38 528842 917 46156265
Scleroderma renal crisis 20.55 10.56 20 528860 251 46156931
Feeling abnormal 20.49 10.56 1183 527697 123877 46033305
Lymphocyte count decreased 20.48 10.56 188 528692 25401 46131781
Cyanosis 20.47 10.56 102 528778 15869 46141313
Angina pectoris 20.46 10.56 199 528681 26576 46130606
Helicobacter infection 20.35 10.56 213 528667 11523 46145659
Acute lymphocytic leukaemia recurrent 20.32 10.56 61 528819 2034 46155148
Osteonecrosis of jaw 20.28 10.56 271 528609 34131 46123051
Tendon rupture 20.26 10.56 154 528726 7605 46149577
Long QT syndrome 20.18 10.56 5 528875 3075 46154107
Stomatitis 20.17 10.56 604 528276 67693 46089489
Lymphocele 20.16 10.56 35 528845 803 46156379
Respiratory acidosis 20.08 10.56 24 528856 6124 46151058
Product complaint 20.04 10.56 70 528810 12031 46145151
Histoplasmosis cutaneous 20 10.56 8 528872 14 46157168
Dacryocystitis 20 10.56 8 528872 14 46157168
Plasmablastic lymphoma 20.00 10.56 19 528861 231 46156951
Blood pressure diastolic increased 19.99 10.56 126 528754 5848 46151334
Immunosuppressant drug level decreased 19.96 10.56 37 528843 895 46156287
Nephrolithiasis 19.93 10.56 503 528377 32548 46124634
Acarodermatitis 19.90 10.56 32 528848 688 46156494
Prothrombin time prolonged 19.88 10.56 50 528830 9546 46147636
Haematochezia 19.85 10.56 561 528319 36932 46120250
Respiratory symptom 19.82 10.56 60 528820 2010 46155172
Pseudomonas infection 19.80 10.56 183 528697 9575 46147607
Visual acuity reduced 19.69 10.56 158 528722 21955 46135227
Pneumatosis intestinalis 19.68 10.56 59 528821 1966 46155216
Babesiosis 19.66 10.56 10 528870 38 46157144
Respiratory tract inflammation 19.63 10.56 25 528855 430 46156752
Nodular rash 19.60 10.56 17 528863 182 46157000
Abortion spontaneous 19.59 10.56 362 528518 43284 46113898
Thrombotic microangiopathy 19.57 10.56 161 528719 8145 46149037
Bloody discharge 19.56 10.56 38 528842 953 46156229
Fluid overload 19.54 10.56 205 528675 26980 46130202
Diplopia 19.50 10.56 134 528746 19271 46137911
Sarcoma of skin 19.50 10.56 9 528871 26 46157156
Gastritis 19.48 10.56 273 528607 34105 46123077
Hypotonia 19.38 10.56 40 528840 8189 46148993
Hypoglycaemic coma 19.34 10.56 3 528877 2571 46154611
Encephalopathy 19.29 10.56 266 528614 33323 46123859
Walking aid user 19.14 10.56 106 528774 4694 46152488
Mood altered 19.11 10.56 79 528801 12928 46144254
Squamous cell carcinoma 19.07 10.56 153 528727 7683 46149499
Torus fracture 19.06 10.56 13 528867 94 46157088
Ventricular septal defect 19.03 10.56 11 528869 4023 46153159
Cervix disorder 18.95 10.56 25 528855 446 46156736
Rhegmatogenous retinal detachment 18.85 10.56 12 528868 76 46157106
Pruritus 18.83 10.56 2431 526449 239921 45917261
T-cell lymphoma 18.83 10.56 29 528851 600 46156582
Pasteurella infection 18.76 10.56 7 528873 9 46157173
Apnoea 18.74 10.56 34 528846 7305 46149877
Acute pulmonary histoplasmosis 18.72 10.56 14 528866 119 46157063
Tooth infection 18.56 10.56 217 528663 12069 46145113
Viral infection 18.48 10.56 461 528419 29774 46127408
Arthritis infective 18.48 10.56 110 528770 5003 46152179
Systemic lupus erythematosus rash 18.42 10.56 43 528837 1229 46155953
Skin lesion 18.38 10.56 414 528466 26299 46130883
Multiple fractures 18.37 10.56 117 528763 5450 46151732
Atrial septal defect 18.35 10.56 27 528853 6305 46150877
B-cell lymphoma stage IV 18.35 10.56 7 528873 10 46157172
Myasthenia gravis crisis 18.24 10.56 22 528858 357 46156825
Giant cell arteritis 18.23 10.56 54 528826 1787 46155395
Chronic obstructive pulmonary disease 18.22 10.56 813 528067 56820 46100362
Pulmonary mass 18.22 10.56 294 528586 17563 46139619
Genitourinary tract infection 18.19 10.56 15 528865 149 46157033
Hepatic encephalopathy 18.03 10.56 57 528823 10100 46147082
Latent tuberculosis 18.01 10.56 56 528824 1904 46155278
X-ray abnormal 17.97 10.56 41 528839 1154 46156028
Cyst 17.96 10.56 213 528667 11887 46145295
Flatulence 17.94 10.56 225 528655 28653 46128529
Complications of bone marrow transplant 17.91 10.56 24 528856 435 46156747
Basal cell carcinoma 17.90 10.56 329 528551 20158 46137024
Atrioventricular block 17.89 10.56 31 528849 6780 46150402
Ammonia increased 17.88 10.56 14 528866 4363 46152819
Mycotic allergy 17.85 10.56 26 528854 511 46156671
Blood prolactin increased 17.83 10.56 6 528874 3021 46154161
Segmental diverticular colitis 17.81 10.56 14 528866 129 46157053
Genital herpes simplex 17.79 10.56 15 528865 154 46157028
Personality change 17.74 10.56 20 528860 5238 46151944
Drug resistance 17.74 10.56 286 528594 17082 46140100
Renal transplant 17.70 10.56 43 528837 1262 46155920
Injury 17.69 10.56 372 528508 43655 46113527
Device issue 17.68 10.56 143 528737 19837 46137345
Pneumocystis jirovecii infection 17.67 10.56 42 528838 1215 46155967
Foot fracture 17.65 10.56 316 528564 19266 46137916
Pleural effusion 17.59 10.56 764 528116 82188 46074994
Renal tubular injury 17.59 10.56 21 528859 337 46156845
Patent ductus arteriosus 17.57 10.56 11 528869 3851 46153331
Dry skin 17.54 10.56 343 528537 40673 46116509
Angina unstable 17.52 10.56 37 528843 7511 46149671
Dyspepsia 17.49 10.56 617 528263 67855 46089327
Metastatic squamous cell carcinoma 17.49 10.56 17 528863 213 46156969
Application site pruritus 17.48 10.56 12 528868 4001 46153181
Substance-induced psychotic disorder 17.44 10.56 48 528832 1522 46155660
Skin fragility 17.42 10.56 27 528853 562 46156620
Kaposi's sarcoma 17.41 10.56 15 528865 159 46157023
Immunoglobulins decreased 17.39 10.56 33 528847 813 46156369
Lupus vasculitis 17.34 10.56 24 528856 449 46156733
Mantle cell lymphoma recurrent 17.33 10.56 13 528867 111 46157071
Sickle cell anaemia with crisis 17.30 10.56 12 528868 3980 46153202
Mouth ulceration 17.27 10.56 412 528468 26420 46130762
Viraemia 17.27 10.56 37 528843 997 46156185
Urine output decreased 17.19 10.56 66 528814 11031 46146151
Pneumonia 17.02 10.56 4648 524232 371672 45785510
Extrasystoles 17.00 10.56 18 528862 4851 46152331
Hypothyroidism 17 10.56 251 528629 31087 46126095
Sinus congestion 16.99 10.56 225 528655 12884 46144298
Mental disorder 16.99 10.56 167 528713 22258 46134924
Candida pneumonia 16.98 10.56 14 528866 139 46157043
Pallor 16.94 10.56 174 528706 22992 46134190
Bone disorder 16.91 10.56 320 528560 19713 46137469
Neck mass 16.84 10.56 78 528802 3215 46153967
Eye disorder 16.80 10.56 294 528586 17847 46139335
Vital capacity decreased 16.71 10.56 26 528854 543 46156639
Metastases to lymph nodes 16.68 10.56 31 528849 6600 46150582
Sensitisation 16.62 10.56 29 528851 668 46156514
Pulse absent 16.56 10.56 19 528861 4937 46152245
Presyncope 16.54 10.56 187 528693 24267 46132915
Large intestinal ulcer 16.53 10.56 75 528805 3064 46154118
Sinusitis fungal 16.52 10.56 33 528847 845 46156337
Antibody test positive 16.45 10.56 58 528822 2107 46155075
Allergy to animal 16.45 10.56 27 528853 591 46156591
Red blood cell count decreased 16.44 10.56 265 528615 32358 46124824
Anuria 16.44 10.56 70 528810 11361 46145821
Diffuse alveolar damage 16.44 10.56 31 528849 760 46156422
Fusarium infection 16.40 10.56 26 528854 552 46156630
Pneumonia legionella 16.40 10.56 43 528837 1324 46155858
Product residue present 16.39 10.56 12 528868 3870 46153312
Body temperature increased 16.39 10.56 383 528497 24478 46132704
Faeces discoloured 16.34 10.56 117 528763 16670 46140512
Bradypnoea 16.28 10.56 7 528873 3032 46154150
Right ventricular failure 16.24 10.56 111 528769 15982 46141200
Thrombocytopenia 16.22 10.56 1224 527656 125357 46031825
Disseminated tuberculosis 16.21 10.56 68 528812 2684 46154498
Hypoaldosteronism 16.21 10.56 15 528865 176 46157006
Intervertebral disc compression 16.19 10.56 35 528845 949 46156233
Femoral neck fracture 16.19 10.56 43 528837 8060 46149122
Incorrect dosage administered 16.18 10.56 49 528831 1642 46155540
Salmonellosis 16.14 10.56 33 528847 860 46156322
Amylase increased 16.09 10.56 23 528857 5436 46151746
Ovarian hyperstimulation syndrome 16.09 10.56 8 528872 3184 46153998
Liver function test increased 16.09 10.56 355 528525 22471 46134711
Pulmonary oedema 16.09 10.56 448 528432 50657 46106525
Choroiditis 16.06 10.56 14 528866 151 46157031
Osteoarthritis 16.06 10.56 858 528022 61167 46096015
Therapeutic product effect delayed 16.04 10.56 53 528827 1862 46155320
Ileal stenosis 16.03 10.56 45 528835 1444 46155738
Impaired quality of life 16.00 10.56 76 528804 3166 46154016
Abdominal abscess 16.00 10.56 90 528790 4009 46153173
Episcleritis 15.98 10.56 30 528850 733 46156449
Eosinophil count abnormal 15.94 10.56 23 528857 448 46156734
Alcohol use 15.93 10.56 4 528876 2438 46154744
Abortion induced 15.91 10.56 61 528819 10199 46146983
Device deployment issue 15.90 10.56 10 528870 3493 46153689
Mycobacterium fortuitum infection 15.81 10.56 8 528872 30 46157152
Disseminated cryptococcosis 15.75 10.56 18 528862 275 46156907
Moraxella infection 15.75 10.56 20 528860 343 46156839
Pulmonary arterial hypertension 15.74 10.56 203 528677 25725 46131457
Urticaria thermal 15.65 10.56 11 528869 84 46157098
Face oedema 15.64 10.56 140 528740 19013 46138169
Libido decreased 15.64 10.56 5 528875 2600 46154582
Lung abscess 15.63 10.56 43 528837 1363 46155819
Diabetic neuropathy 15.63 10.56 12 528868 3777 46153405
Neurosarcoidosis 15.62 10.56 15 528865 185 46156997
Subarachnoid haemorrhage 15.61 10.56 69 528811 11084 46146098
Blastomycosis 15.59 10.56 17 528863 246 46156936
Chorioretinitis 15.58 10.56 19 528861 312 46156870
Hypomania 15.57 10.56 16 528864 4372 46152810
Rash maculo-papular 15.56 10.56 222 528658 27652 46129530
Maternal drugs affecting foetus 15.54 10.56 24 528856 5494 46151688
Abdominal pain lower 15.52 10.56 159 528721 21022 46136160
Peptic ulcer haemorrhage 15.51 10.56 35 528845 978 46156204
Antisynthetase syndrome 15.51 10.56 9 528871 47 46157135
Cholelithiasis 15.49 10.56 327 528553 38354 46118828
Aphthous ulcer 15.49 10.56 171 528709 9377 46147805
Blood potassium decreased 15.47 10.56 321 528559 37742 46119440
Graft versus host disease in lung 15.45 10.56 19 528861 315 46156867
Gastroenteritis norovirus 15.44 10.56 46 528834 1527 46155655
Device leakage 15.43 10.56 23 528857 5342 46151840
Application site rash 15.42 10.56 5 528875 2577 46154605
Scedosporium infection 15.40 10.56 24 528856 502 46156680
Bronchial wall thickening 15.36 10.56 31 528849 800 46156382
Erythema nodosum 15.36 10.56 84 528796 3702 46153480
Atypical haemolytic uraemic syndrome 15.32 10.56 23 528857 465 46156717
Pseudopolyp 15.30 10.56 16 528864 220 46156962
Impaired healing 15.29 10.56 534 528346 36209 46120973
Muscle injury 15.29 10.56 101 528779 4765 46152417
Leishmaniasis 15.24 10.56 8 528872 33 46157149
Menstruation irregular 15.22 10.56 32 528848 6507 46150675
Systemic bacterial infection 15.18 10.56 6 528874 10 46157172
Pigment nephropathy 15.18 10.56 6 528874 10 46157172
Pulmonary aplasia 15.18 10.56 6 528874 10 46157172
Oesophageal dilatation 15.18 10.56 19 528861 321 46156861
Hypovolaemic shock 15.12 10.56 22 528858 5161 46152021
Respiratory tract infection fungal 15.05 10.56 21 528859 396 46156786
Application site pain 15.05 10.56 14 528866 4009 46153173
Prescribed overdose 15.02 10.56 64 528816 10385 46146797
Bone density abnormal 15.00 10.56 72 528808 3012 46154170
Perinephric abscess 15.00 10.56 13 528867 139 46157043
Drug abuser 14.99 10.56 9 528871 3224 46153958
Segmented hyalinising vasculitis 14.98 10.56 7 528873 21 46157161
Aplasia 14.95 10.56 80 528800 3496 46153686
Emphysematous pyelonephritis 14.95 10.56 14 528866 167 46157015
Tongue oedema 14.92 10.56 14 528866 3992 46153190
Product dispensing error 14.90 10.56 54 528826 9179 46148003
Perinephric collection 14.89 10.56 12 528868 115 46157067
Mycobacterium abscessus infection 14.87 10.56 26 528854 600 46156582
Pedal pulse abnormal 14.85 10.56 13 528867 141 46157041
Joint dislocation reduction 14.83 10.56 6 528874 11 46157171
Nephrotic syndrome 14.77 10.56 101 528779 4820 46152362
Lymphadenopathy 14.77 10.56 490 528390 32998 46124184
Abdominal wall infection 14.75 10.56 11 528869 93 46157089
Glaucoma 14.73 10.56 258 528622 15663 46141519
Cytomegalovirus chorioretinitis 14.73 10.56 44 528836 1463 46155719
Thirst 14.71 10.56 69 528811 10907 46146275
Osteopenia 14.69 10.56 272 528608 16689 46140493
Swollen joint count increased 14.68 10.56 60 528820 2340 46154842
Hyperreflexia 14.65 10.56 23 528857 5231 46151951
Tenosynovitis stenosans 14.62 10.56 52 528828 1897 46155285
Intestinal stenosis 14.62 10.56 62 528818 2459 46154723
Conjunctival irritation 14.57 10.56 5 528875 4 46157178
Spinal disorder 14.56 10.56 147 528733 7877 46149305
Cerebral haematoma 14.52 10.56 10 528870 3329 46153853
Upper respiratory tract infection 14.48 10.56 869 528011 62687 46094495
Factor XIII deficiency 14.47 10.56 10 528870 74 46157108
Metabolic alkalosis 14.45 10.56 6 528874 2654 46154528
Pleural thickening 14.42 10.56 63 528817 2532 46154650
Colectomy total 14.41 10.56 12 528868 121 46157061
Rib fracture 14.40 10.56 298 528582 18656 46138526
Grip strength decreased 14.36 10.56 155 528725 8451 46148731
Pleural fibrosis 14.35 10.56 79 528801 3490 46153692
Nasal oedema 14.33 10.56 31 528849 841 46156341
Emotional distress 14.31 10.56 253 528627 30454 46126728
Urinary tract infection viral 14.30 10.56 7 528873 24 46157158
Eosinophilic fasciitis 14.29 10.56 11 528869 98 46157084
Blood thyroid stimulating hormone increased 14.27 10.56 28 528852 5841 46151341
Underdose 14.26 10.56 147 528733 19411 46137771
Defaecation urgency 14.25 10.56 64 528816 2603 46154579
Acute hepatitis B 14.25 10.56 18 528862 307 46156875
Hospitalisation 14.23 10.56 580 528300 62805 46094377
Ileus 14.19 10.56 97 528783 13967 46143215
Hypertensive crisis 14.19 10.56 93 528787 13522 46143660
Head injury 14.18 10.56 195 528685 24441 46132741
Visual impairment 14.18 10.56 614 528266 66075 46091107
Sputum abnormal 14.15 10.56 19 528861 345 46156837
Disseminated large cell lymphoma 14.14 10.56 9 528871 57 46157125
Drug specific antibody present 14.14 10.56 70 528810 2966 46154216
Anal incontinence 14.10 10.56 77 528803 11701 46145481
Upper respiratory fungal infection 14.10 10.56 12 528868 125 46157057
Deep vein thrombosis 14.09 10.56 749 528131 79024 46078158
Clubbing 14.09 10.56 17 528863 276 46156906
Nystagmus 14.02 10.56 27 528853 5672 46151510
Paracoccidioides infection 13.97 10.56 4 528876 0 46157182
Soft tissue neoplasm 13.97 10.56 4 528876 0 46157182
Autoimmune inner ear disease 13.97 10.56 4 528876 0 46157182
Abscess 13.92 10.56 228 528652 13661 46143521
Pneumonia aspiration 13.91 10.56 263 528617 31342 46125840
Cardiovascular disorder 13.87 10.56 81 528799 12106 46145076
Granulocytopenia 13.85 10.56 24 528856 5249 46151933
Impaired gastric emptying 13.84 10.56 46 528834 8026 46149156
Smoke sensitivity 13.82 10.56 16 528864 248 46156934
Philadelphia chromosome positive 13.81 10.56 17 528863 282 46156900
Device related infection 13.80 10.56 162 528718 20879 46136303
Oxygen saturation decreased 13.80 10.56 935 527945 68229 46088953
Eosinophilic granulomatosis with polyangiitis 13.79 10.56 49 528831 1787 46155395
Salmonella bacteraemia 13.77 10.56 11 528869 104 46157078
Primary immunodeficiency syndrome 13.75 10.56 8 528872 42 46157140
Exposure to toxic agent 13.73 10.56 3 528877 2011 46155171
Cholestasis 13.70 10.56 218 528662 26675 46130507
Glomerular filtration rate decreased 13.70 10.56 77 528803 11617 46145565
Embedded device 13.69 10.56 8 528872 2908 46154274
Legionella infection 13.66 10.56 20 528860 395 46156787
Herpes simplex oesophagitis 13.65 10.56 12 528868 131 46157051
Rectal prolapse 13.64 10.56 44 528836 1526 46155656
Pulmonary hypertension 13.63 10.56 307 528573 35686 46121496
Perihepatic abscess 13.60 10.56 6 528874 15 46157167
Fryns syndrome 13.54 10.56 9 528871 62 46157120
Petit mal epilepsy 13.54 10.56 10 528870 3210 46153972
Anovulatory cycle 13.51 10.56 12 528868 133 46157049
Respiratory rate increased 13.50 10.56 193 528687 11240 46145942
Rash 13.49 10.56 4372 524508 352140 45805042
Neoplasm recurrence 13.48 10.56 58 528822 2315 46154867
Cytomegalovirus infection reactivation 13.47 10.56 42 528838 1430 46155752
Low density lipoprotein increased 13.44 10.56 30 528850 5970 46151212
Paranoia 13.40 10.56 68 528812 10529 46146653
Gouty tophus 13.37 10.56 13 528867 163 46157019
Encephalitis brain stem 13.36 10.56 11 528869 109 46157073
Alcohol abuse 13.34 10.56 4 528876 2168 46155014
Intervertebral disc space narrowing 13.32 10.56 30 528850 837 46156345
Skin papilloma 13.31 10.56 87 528793 4089 46153093
Asphyxia 13.31 10.56 25 528855 5301 46151881
Myelodysplastic syndrome 13.27 10.56 251 528629 15460 46141722
Ophthalmic herpes zoster 13.27 10.56 43 528837 1495 46155687
Small for dates baby 13.21 10.56 13 528867 3624 46153558
Hepatocellular injury 13.20 10.56 245 528635 29277 46127905
Meningitis histoplasma 13.16 10.56 5 528875 7 46157175
Intestinal fibrosis 13.16 10.56 12 528868 138 46157044
Gastric disorder 13.16 10.56 396 528484 26309 46130873
Lymph node calcification 13.12 10.56 13 528867 167 46157015
Cytomegalovirus oesophagitis 13.08 10.56 15 528865 230 46156952
Amenorrhoea 13.08 10.56 54 528826 8841 46148341
Middle insomnia 13.04 10.56 165 528715 9350 46147832
Gastrosplenic fistula 13.04 10.56 8 528872 47 46157135
Polyuria 13.04 10.56 40 528840 7155 46150027
Body temperature fluctuation 13.03 10.56 48 528832 1782 46155400
Acute myelomonocytic leukaemia 13.03 10.56 14 528866 199 46156983
Rhodococcus infection 13.00 10.56 10 528870 89 46157093
Platelet count abnormal 12.97 10.56 64 528816 2708 46154474
White blood cell count abnormal 12.92 10.56 101 528779 5031 46152151
Polymyositis 12.91 10.56 44 528836 1571 46155611
Oesophageal candidiasis 12.91 10.56 102 528778 5098 46152084
Hepatitis E 12.90 10.56 37 528843 1202 46155980
Osteomyelitis bacterial 12.88 10.56 13 528867 171 46157011
Affect lability 12.88 10.56 47 528833 7973 46149209
Anaplastic large cell lymphoma T- and null-cell types 12.88 10.56 9 528871 68 46157114
Heparin-induced thrombocytopenia 12.86 10.56 18 528862 4291 46152891
Cardiogenic shock 12.84 10.56 121 528759 16263 46140919
Bronchopulmonary aspergillosis allergic 12.81 10.56 27 528853 719 46156463
Coronary artery stenosis 12.80 10.56 21 528859 4692 46152490
Vasomotor rhinitis 12.78 10.56 8 528872 49 46157133
Animal scratch 12.76 10.56 27 528853 721 46156461
Complications of transplant surgery 12.76 10.56 13 528867 173 46157009
Polydipsia 12.76 10.56 11 528869 3268 46153914
Premature delivery 12.76 10.56 334 528546 21735 46135447
Sputum purulent 12.74 10.56 29 528851 815 46156367
Laboratory test abnormal 12.74 10.56 182 528698 22665 46134517
Thyroid neoplasm 12.66 10.56 78 528802 3591 46153591
Ageusia 12.66 10.56 77 528803 11395 46145787
Avian influenza 12.65 10.56 8 528872 50 46157132
Acute biphenotypic leukaemia 12.65 10.56 8 528872 50 46157132
Weight fluctuation 12.62 10.56 122 528758 6462 46150720
Pancreas transplant 12.60 10.56 6 528874 19 46157163
Adrenal suppression 12.54 10.56 31 528849 920 46156262
Therapy cessation 12.54 10.56 219 528661 26410 46130772
Gastroenteritis viral 12.52 10.56 281 528599 17838 46139344
Food intolerance 12.49 10.56 56 528824 2276 46154906
Rhonchi 12.48 10.56 54 528826 2161 46155021
Viral upper respiratory tract infection 12.46 10.56 128 528752 6890 46150292
Skin infection 12.45 10.56 189 528691 11150 46146032
Urinary tract candidiasis 12.42 10.56 22 528858 513 46156669
Eye movement disorder 12.42 10.56 22 528858 4771 46152411
Forced vital capacity decreased 12.42 10.56 30 528850 877 46156305
Tendon disorder 12.41 10.56 98 528782 4897 46152285
Toothache 12.39 10.56 124 528756 16468 46140714
Skin graft rejection 12.38 10.56 6 528874 20 46157162
Bronchial obstruction 12.36 10.56 38 528842 1284 46155898
Cardiac failure chronic 12.34 10.56 13 528867 3511 46153671
Fibromyalgia 12.33 10.56 518 528362 35945 46121237
Acidosis 12.33 10.56 75 528805 11099 46146083
Sexual abuse 12.30 10.56 11 528869 123 46157059
Left ventricular dysfunction 12.30 10.56 67 528813 10188 46146994
Obsessive-compulsive disorder 12.25 10.56 11 528869 3204 46153978
Aplasia pure red cell 12.22 10.56 89 528791 4336 46152846
Cholecystitis acute 12.22 10.56 44 528836 7494 46149688
Limb injury 12.21 10.56 294 528586 18880 46138302
Blood test abnormal 12.18 10.56 163 528717 9357 46147825
Proteinuria 12.17 10.56 259 528621 16294 46140888
Necrotising ulcerative gingivostomatitis 12.16 10.56 6 528874 21 46157161
Malignant anorectal neoplasm 12.16 10.56 6 528874 21 46157161
Bone marrow granuloma 12.16 10.56 6 528874 21 46157161
Myasthenia gravis 12.16 10.56 74 528806 3392 46153790
Fracture delayed union 12.14 10.56 53 528827 2129 46155053
Infusion site pain 12.14 10.56 66 528814 10041 46147141
Multiple-drug resistance 12.09 10.56 7 528873 2558 46154624
Chronic hepatitis 12.09 10.56 28 528852 796 46156386
Microtia 12.09 10.56 17 528863 323 46156859
Endocarditis Q fever 12.08 10.56 5 528875 10 46157172
Blood bicarbonate decreased 12.08 10.56 9 528871 2876 46154306
Therapeutic response delayed 12.01 10.56 22 528858 527 46156655
Breast cancer recurrent 12.01 10.56 16 528864 3895 46153287
Hepatitis acute 12.00 10.56 50 528830 8164 46149018
Diarrhoea haemorrhagic 11.96 10.56 134 528746 7375 46149807
Systemic mycosis 11.95 10.56 30 528850 899 46156283
Abscess intestinal 11.95 10.56 38 528842 1308 46155874
Rales 11.95 10.56 164 528716 9467 46147715
Electrolyte imbalance 11.94 10.56 131 528749 17095 46140087
Headache 11.87 10.56 5066 523814 473286 45683896
Gastrointestinal stoma output abnormal 11.85 10.56 7 528873 38 46157144
Acute hepatic failure 11.85 10.56 108 528772 14613 46142569
Catabolic state 11.82 10.56 8 528872 57 46157125
Metastases to spine 11.81 10.56 8 528872 2686 46154496
Chorioretinopathy 11.79 10.56 26 528854 715 46156467
Medical device discomfort 11.78 10.56 4 528876 2002 46155180
Enterobiasis 11.76 10.56 4 528876 3 46157179
Prophylaxis against transplant rejection 11.76 10.56 6 528874 23 46157159
Herpes zoster cutaneous disseminated 11.76 10.56 11 528869 131 46157051
Anal abscess 11.75 10.56 75 528805 3497 46153685
Presbyacusis 11.71 10.56 63 528817 2759 46154423
Synovial disorder 11.69 10.56 28 528852 814 46156368
Second primary malignancy 11.65 10.56 120 528760 6464 46150718
Stress cardiomyopathy 11.61 10.56 47 528833 7737 46149445
Biloma 11.60 10.56 8 528872 59 46157123
Anhedonia 11.60 10.56 69 528811 10266 46146916
Disseminated mycobacterium avium complex infection 11.57 10.56 7 528873 40 46157142
Pancreas transplant rejection 11.56 10.56 11 528869 134 46157048
Androgenetic alopecia 11.53 10.56 12 528868 164 46157018
Dysuria 11.53 10.56 234 528646 27599 46129583
Sporotrichosis 11.48 10.56 5 528875 12 46157170
Bacteraemia 11.46 10.56 225 528655 13954 46143228
Encephalitis 11.45 10.56 132 528748 7316 46149866
Folliculitis 11.43 10.56 114 528766 6089 46151093
Nephropathy toxic 11.41 10.56 132 528748 7322 46149860
Enterobacter infection 11.41 10.56 47 528833 1840 46155342
Malignant melanoma 11.39 10.56 171 528709 10063 46147119
Enterocolitis 11.38 10.56 34 528846 6134 46151048
Meningoencephalitis viral 11.38 10.56 16 528864 304 46156878
Congenital osteodystrophy 11.38 10.56 6 528874 25 46157157
Tinnitus 11.36 10.56 233 528647 27440 46129742
Abscess rupture 11.31 10.56 13 528867 200 46156982
Autoimmune disorder 11.30 10.56 84 528796 4119 46153063
Lipomatosis 11.30 10.56 7 528873 42 46157140
Cutaneous T-cell dyscrasia 11.28 10.56 8 528872 62 46157120
Chest discomfort 11.27 10.56 1178 527702 89091 46068091
Diabetic retinopathy 11.26 10.56 6 528874 2296 46154886
Prescribed underdose 11.26 10.56 85 528795 11968 46145214
Extranodal marginal zone B-cell lymphoma (MALT type) stage IV 11.24 10.56 4 528876 4 46157178
Septic vasculitis 11.24 10.56 4 528876 4 46157178
Pseudoxanthoma elasticum-like syndrome 11.24 10.56 4 528876 4 46157178
Cataract traumatic 11.24 10.56 4 528876 4 46157178
Pelvic pain 11.23 10.56 81 528799 11521 46145661
Atrioventricular block second degree 11.21 10.56 16 528864 3783 46153399
Peritonitis 11.20 10.56 166 528714 20548 46136634
Idiopathic angioedema 11.20 10.56 5 528875 13 46157169
Acute hepatitis C 11.19 10.56 9 528871 86 46157096
Pharyngeal inflammation 11.18 10.56 22 528858 557 46156625
Pain in jaw 11.17 10.56 340 528540 38032 46119150
Stoma site discharge 11.16 10.56 4 528876 1936 46155246
Duodenal ulcer 11.13 10.56 43 528837 7175 46150007
Monoclonal gammopathy 11.13 10.56 23 528857 604 46156578
Dialysis 11.11 10.56 68 528812 10048 46147134
Glomerulonephropathy 11.11 10.56 9 528871 87 46157095
Calcium ionised decreased 11.07 10.56 14 528866 239 46156943
Cardiomyopathy acute 11.06 10.56 13 528867 205 46156977
Subdural haemorrhage 11.05 10.56 10 528870 2902 46154280
Coagulation test abnormal 11.05 10.56 24 528856 653 46156529
Extrapulmonary tuberculosis 11.02 10.56 15 528865 276 46156906
Haemorrhage subcutaneous 11.01 10.56 10 528870 2896 46154286
Bone erosion 10.99 10.56 159 528721 9284 46147898
Glomerulonephritis 10.98 10.56 41 528839 1532 46155650
Incontinence 10.98 10.56 66 528814 9796 46147386
Injection site mass 10.98 10.56 113 528767 14927 46142255
Lip swelling 10.97 10.56 212 528668 25183 46131999
Lacunar infarction 10.97 10.56 14 528866 3471 46153711
Abdominal distension 10.92 10.56 700 528180 72651 46084531
Nodal rhythm 10.92 10.56 3 528877 1722 46155460
Type III immune complex mediated reaction 10.92 10.56 13 528867 208 46156974
Arteriosclerosis 10.91 10.56 65 528815 9668 46147514
Eructation 10.91 10.56 44 528836 7251 46149931
Ectopic pregnancy 10.88 10.56 8 528872 2574 46154608
Oedema 10.88 10.56 635 528245 66436 46090746
Bundle branch block right 10.87 10.56 24 528856 4795 46152387
Pulseless electrical activity 10.86 10.56 43 528837 7124 46150058
Pneumonia pseudomonal 10.85 10.56 50 528830 2056 46155126
Cerebellar syndrome 10.82 10.56 14 528866 3451 46153731
Heart rate decreased 10.81 10.56 451 528429 31272 46125910
Congenital nail disorder 10.79 10.56 9 528871 91 46157091
Crepitations 10.77 10.56 111 528769 5981 46151201
Spondyloarthropathy 10.76 10.56 24 528856 665 46156517
Haemophilus infection 10.76 10.56 29 528851 908 46156274
Gait disturbance 10.76 10.56 1837 527043 143426 46013756
Intestinal anastomosis 10.75 10.56 15 528865 283 46156899
Bacterial translocation 10.73 10.56 13 528867 212 46156970
Pleuropericarditis 10.73 10.56 13 528867 212 46156970
Sensory loss 10.72 10.56 41 528839 6861 46150321
Joint fluid drainage 10.72 10.56 12 528868 179 46157003
Small cell lung cancer recurrent 10.70 10.56 5 528875 15 46157167
T-cell type acute leukaemia 10.69 10.56 8 528872 68 46157114
Osteonecrosis 10.67 10.56 374 528506 25370 46131812
Activated partial thromboplastin time prolonged 10.65 10.56 41 528839 6848 46150334
Bronchial secretion retention 10.64 10.56 29 528851 914 46156268
Stomatococcal infection 10.63 10.56 9 528871 93 46157089
Palindromic rheumatism 10.63 10.56 10 528870 120 46157062
Quality of life decreased 10.61 10.56 105 528775 5597 46151585
Breast cyst excision 10.60 10.56 8 528872 69 46157113
Prolonged expiration 10.59 10.56 17 528863 365 46156817
Lymphadenectomy 10.56 10.56 28 528852 868 46156314

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 568.10 11.14 137 292608 99355 29560378
Product use in unapproved indication 529.24 11.14 1754 290991 71939 29587794
Drug abuse 518.33 11.14 89 292656 81983 29577750
Colitis ulcerative 513.85 11.14 669 292076 13765 29645968
Drug ineffective 481.11 11.14 5256 287489 335131 29324602
Asthma 476.01 11.14 1076 291669 35098 29624635
Rheumatoid arthritis 430.34 11.14 1121 291624 40076 29619657
Off label use 414.68 11.14 3982 288763 245308 29414425
Nocardiosis 393.55 11.14 302 292443 3153 29656580
Polyomavirus-associated nephropathy 348.83 11.14 272 292473 2913 29656820
Transplant rejection 342.23 11.14 436 292309 8770 29650963
Post transplant lymphoproliferative disorder 334.53 11.14 331 292414 4975 29654758
Kidney transplant rejection 311.85 11.14 376 292369 7133 29652600
Overdose 298.76 11.14 232 292513 84105 29575628
Intentional overdose 284.92 11.14 35 292710 41446 29618287
Toxicity to various agents 266.88 11.14 866 291879 176317 29483416
Death 257.45 11.14 2246 290499 355037 29304696
Aspergillus infection 249.65 11.14 396 292349 9818 29649915
Cytomegalovirus infection 240.77 11.14 638 292107 23036 29636697
Strongyloidiasis 209.76 11.14 178 292567 2168 29657565
Therapeutic product effect incomplete 206.79 11.14 764 291981 33070 29626663
Somnolence 196.91 11.14 406 292339 96357 29563376
Mucormycosis 196.59 11.14 250 292495 5018 29654715
Wheezing 186.05 11.14 695 292050 30243 29629490
Bradycardia 185.66 11.14 220 292525 65306 29594427
Pneumocystis jirovecii pneumonia 181.86 11.14 469 292276 16651 29643082
Phaeohyphomycosis 175.98 11.14 106 292639 712 29659021
Fall 175.16 11.14 1051 291694 180821 29478912
Blood pressure fluctuation 172.21 11.14 466 292279 17037 29642696
Myocardial infarction 168.18 11.14 645 292100 124980 29534753
Condition aggravated 164.91 11.14 2065 290680 135801 29523932
Loss of consciousness 160.65 11.14 334 292411 79041 29580692
Histoplasmosis 158.25 11.14 117 292628 1149 29658584
Rhabdomyolysis 158.15 11.14 235 292510 63345 29596388
Obstructive airways disorder 157.17 11.14 302 292443 8757 29650976
Intentional product use issue 155.37 11.14 737 292008 35703 29624030
Transplant dysfunction 154.37 11.14 150 292595 2202 29657531
Epstein-Barr virus infection 154.33 11.14 253 292492 6453 29653280
Joint swelling 148.33 11.14 874 291871 46072 29613661
Suicide attempt 147.15 11.14 88 292657 36609 29623124
BK virus infection 145.60 11.14 196 292549 4168 29655565
Cryptococcosis 145.50 11.14 129 292616 1673 29658060
Progressive multifocal leukoencephalopathy 144.90 11.14 291 292454 8722 29651011
Hypoglycaemia 144.57 11.14 171 292574 50810 29608923
Arthralgia 143.64 11.14 1989 290756 133802 29525931
Dizziness 143.02 11.14 1218 291527 193691 29466042
Confusional state 142.82 11.14 755 291990 134079 29525654
Complications of transplanted kidney 139.60 11.14 186 292559 3915 29655818
Disease recurrence 139.28 11.14 377 292368 13784 29645949
Hypotension 138.51 11.14 1273 291472 199292 29460441
Aggression 137.76 11.14 96 292649 36811 29622922
Frequent bowel movements 137.07 11.14 273 292472 8132 29651601
Diffuse large B-cell lymphoma 136.77 11.14 262 292483 7579 29652154
Electrocardiogram QT prolonged 136.71 11.14 91 292654 35744 29623989
Agitation 135.31 11.14 199 292546 53874 29605859
Seizure 131.48 11.14 506 292239 97969 29561764
Blood creatine phosphokinase increased 129.84 11.14 142 292603 43706 29616027
Diffuse large B-cell lymphoma recurrent 127.25 11.14 128 292617 1964 29657769
West Nile viral infection 127.03 11.14 77 292668 524 29659209
Cardio-respiratory arrest 126.47 11.14 229 292516 57077 29602656
Cytomegalovirus viraemia 123.63 11.14 210 292535 5519 29654214
Histoplasmosis disseminated 122.54 11.14 90 292655 874 29658859
Hepatic function abnormal 120.74 11.14 139 292606 41806 29617927
Productive cough 120.62 11.14 596 292149 29357 29630376
Hallucination 118.45 11.14 185 292560 48874 29610859
Sleep disorder due to a general medical condition 117.95 11.14 106 292639 1401 29658332
Bronchopulmonary aspergillosis 115.80 11.14 322 292423 11962 29647771
Chronic allograft nephropathy 115.75 11.14 94 292651 1072 29658661
Depressed level of consciousness 110.73 11.14 126 292619 38096 29621637
Intentional product misuse 108.58 11.14 107 292638 34560 29625173
Hepatitis B reactivation 108.08 11.14 137 292608 2740 29656993
COVID-19 107.76 11.14 402 292343 17476 29642257
Coma 106.01 11.14 144 292601 40305 29619428
Serotonin syndrome 103.24 11.14 24 292721 17867 29641866
JC virus infection 100.67 11.14 105 292640 1685 29658048
Cardiac arrest 98.18 11.14 520 292225 92330 29567403
Focal segmental glomerulosclerosis 97.12 11.14 104 292641 1723 29658010
Syncope 96.31 11.14 464 292281 84439 29575294
Acute kidney injury 94.84 11.14 1999 290746 271843 29387890
Rebound effect 94.01 11.14 95 292650 1466 29658267
Neuroleptic malignant syndrome 93.75 11.14 22 292723 16273 29643460
Sputum discoloured 92.85 11.14 203 292542 6465 29653268
Cytomegalovirus colitis 92.10 11.14 115 292630 2264 29657469
Loss of personal independence in daily activities 91.36 11.14 435 292310 21100 29638633
Forced expiratory volume decreased 90.68 11.14 134 292611 3116 29656617
Renal transplant failure 90.41 11.14 78 292667 973 29658760
Brain abscess 90.34 11.14 121 292624 2560 29657173
Product use issue 90.22 11.14 763 291982 45253 29614480
Cerebral infarction 89.00 11.14 76 292669 26297 29633436
Blood count abnormal 88.54 11.14 283 292462 11369 29648364
Cardiac failure congestive 88.52 11.14 474 292271 83933 29575800
Therapeutic product effect decreased 88.40 11.14 536 292209 28540 29631193
Cryptosporidiosis infection 88.34 11.14 50 292695 294 29659439
Immunosuppressant drug level increased 88.09 11.14 162 292583 4540 29655193
Restlessness 88.08 11.14 56 292689 22543 29637190
Angioedema 87.51 11.14 125 292620 34259 29625474
Suicidal ideation 87.34 11.14 136 292609 35978 29623755
Varicella zoster virus infection 87.24 11.14 83 292662 1185 29658548
Adenovirus infection 86.28 11.14 152 292593 4116 29655617
Nasal congestion 86.13 11.14 385 292360 18181 29641552
Graft loss 86.07 11.14 70 292675 800 29658933
Abnormal behaviour 85.06 11.14 75 292670 25548 29634185
Sedation 81.52 11.14 29 292716 16344 29643389
Febrile neutropenia 81.33 11.14 1480 291265 105213 29554520
Therapy partial responder 80.57 11.14 136 292609 3555 29656178
Intentional self-injury 80.40 11.14 17 292728 13515 29646218
Cough 79.67 11.14 1695 291050 123947 29535786
Crohn's disease 79.09 11.14 148 292597 4204 29655529
Posterior reversible encephalopathy syndrome 78.90 11.14 225 292520 8482 29651251
Treatment failure 78.88 11.14 595 292150 34084 29625649
Respiratory arrest 78.87 11.14 102 292643 29156 29630577
Delirium 78.80 11.14 175 292570 40456 29619277
Cerebrovascular accident 78.29 11.14 486 292259 82991 29576742
Drug level below therapeutic 78.09 11.14 128 292617 3264 29656469
Human herpesvirus 8 infection 77.97 11.14 60 292685 629 29659104
Sensitivity to weather change 77.70 11.14 83 292662 1371 29658362
Coronary artery disease 77.41 11.14 239 292506 49473 29610260
International normalised ratio increased 76.86 11.14 226 292519 47513 29612220
Bronchiectasis 76.56 11.14 162 292583 5042 29654691
Kidney fibrosis 76.30 11.14 98 292647 1987 29657746
Nausea 75.71 11.14 2268 290477 294689 29365044
Fungal infection 75.55 11.14 298 292447 13302 29646431
Hyponatraemia 74.61 11.14 370 292375 66832 29592901
Lung transplant rejection 74.04 11.14 61 292684 711 29659022
Pulmonary mass 73.78 11.14 254 292491 10608 29649125
Rash 73.47 11.14 1377 291368 190512 29469221
Lactic acidosis 73.16 11.14 120 292625 31093 29628640
Mycobacterial infection 72.80 11.14 87 292658 1634 29658099
Faecal calprotectin increased 71.76 11.14 72 292673 1101 29658632
Extrapyramidal disorder 71.06 11.14 10 292735 10683 29649050
Drug interaction 70.68 11.14 1451 291294 198117 29461616
Alternaria infection 70.59 11.14 42 292703 275 29659458
Herpes zoster 70.51 11.14 518 292227 29425 29630308
Cardiac failure 70.51 11.14 501 292244 82917 29576816
Renal tubular atrophy 70.20 11.14 68 292677 994 29658739
Constipation 69.64 11.14 736 292009 112170 29547563
Arthropathy 69.41 11.14 392 292353 20335 29639398
Prostate cancer metastatic 69.13 11.14 153 292592 4914 29654819
Prostatic specific antigen increased 69.10 11.14 266 292479 11738 29647995
Schizophrenia 69.08 11.14 5 292740 9043 29650690
Dyskinesia 68.82 11.14 67 292678 21767 29637966
Acute myocardial infarction 67.43 11.14 277 292468 52662 29607071
Musculoskeletal stiffness 67.20 11.14 589 292156 35292 29624441
Clostridium difficile infection 67.08 11.14 319 292426 15464 29644269
Lymphadenopathy 67.02 11.14 438 292307 23938 29635795
Depression 66.68 11.14 564 292181 89873 29569860
Blastomycosis 65.59 11.14 39 292706 255 29659478
Nasal polyps 65.51 11.14 74 292671 1305 29658428
Liver disorder 65.34 11.14 119 292626 29603 29630130
Respiratory depression 65.25 11.14 16 292729 11487 29648246
Colitis 65.21 11.14 520 292225 30300 29629433
Pneumonia aspiration 63.64 11.14 175 292570 37605 29622128
Infusion related reaction 63.54 11.14 641 292104 39923 29619810
Hepatitis B 63.09 11.14 165 292580 5907 29653826
Infection reactivation 63.01 11.14 61 292684 891 29658842
Pneumonia cytomegaloviral 62.33 11.14 104 292641 2692 29657041
Vomiting 62.26 11.14 1654 291091 218164 29441569
General physical health deterioration 62.24 11.14 650 292095 99294 29560439
Mycobacterium avium complex infection 62.00 11.14 102 292643 2609 29657124
Pseudomonas infection 61.75 11.14 234 292511 10248 29649485
Foot deformity 61.36 11.14 116 292629 3321 29656412
Second primary malignancy 61.28 11.14 168 292577 6188 29653545
Infection 61.22 11.14 1088 291657 76986 29582747
Parvovirus B19 infection 60.95 11.14 48 292697 522 29659211
Circulatory collapse 60.34 11.14 65 292680 20149 29639584
Aspartate aminotransferase increased 60.09 11.14 368 292377 63054 29596679
Septic shock 60.09 11.14 914 291831 62693 29597040
Cerebral aspergillosis 59.67 11.14 70 292675 1288 29658445
Scedosporium infection 59.36 11.14 52 292693 663 29659070
Arthritis 59.10 11.14 425 292320 23976 29635757
Pemphigus 58.77 11.14 67 292678 1194 29658539
Immunoglobulin G4 related disease 58.51 11.14 25 292720 69 29659664
Osteoporosis 57.91 11.14 232 292513 10431 29649302
Drug withdrawal syndrome 57.69 11.14 65 292680 19744 29639989
Diffuse large B-cell lymphoma refractory 57.57 11.14 53 292692 724 29659009
Epistaxis 57.49 11.14 294 292451 52687 29607046
Irritability 57.47 11.14 85 292660 22965 29636768
Immunosuppression 57.26 11.14 144 292601 5031 29654702
Graft versus host disease in lung 56.66 11.14 44 292701 468 29659265
Altered state of consciousness 55.18 11.14 68 292677 19851 29639882
Steroid diabetes 54.58 11.14 65 292680 1216 29658517
Legionella infection 53.92 11.14 39 292706 369 29659364
Central nervous system lymphoma 53.81 11.14 54 292691 826 29658907
Escherichia infection 53.70 11.14 161 292584 6244 29653489
Disorientation 52.57 11.14 146 292599 31272 29628461
Fungal skin infection 52.28 11.14 89 292656 2343 29657390
Rheumatoid factor positive 51.86 11.14 42 292703 477 29659256
Orthostatic hypotension 51.83 11.14 97 292648 23882 29635851
Palmar-plantar erythrodysaesthesia syndrome 51.22 11.14 42 292703 14828 29644905
Rhodococcus infection 51.10 11.14 28 292717 153 29659580
Erectile dysfunction 50.99 11.14 61 292684 18041 29641692
Cushingoid 50.83 11.14 89 292656 2398 29657335
Delayed graft function 50.08 11.14 73 292672 1676 29658057
Dysarthria 50.04 11.14 143 292602 30347 29629386
Osteonecrosis 50.02 11.14 299 292446 15836 29643897
Haematemesis 49.87 11.14 114 292631 26089 29633644
Stevens-Johnson syndrome 49.62 11.14 59 292686 17497 29642236
Sinus pain 49.01 11.14 46 292699 645 29659088
Poisoning 48.94 11.14 25 292720 11357 29648376
Meningitis cryptococcal 48.80 11.14 78 292667 1946 29657787
Herpes simplex 48.12 11.14 123 292622 4341 29655392
Encephalitis viral 48.05 11.14 59 292686 1141 29658592
Miosis 47.81 11.14 9 292736 7767 29651966
Hyperkalaemia 47.59 11.14 414 292331 65596 29594137
Anxiety 47.56 11.14 606 292139 89265 29570468
White blood cell count decreased 47.47 11.14 558 292187 83389 29576344
Lymphopenia 47.46 11.14 254 292491 12909 29646824
Bacillary angiomatosis 47.38 11.14 20 292725 53 29659680
Gastroenteritis norovirus 47.29 11.14 64 292681 1368 29658365
Candida infection 47.19 11.14 284 292461 15078 29644655
Respiratory failure 47.17 11.14 1303 291442 99339 29560394
Decreased appetite 46.96 11.14 1111 291634 148799 29510934
Therapeutic response decreased 46.78 11.14 402 292343 23947 29635786
Alanine aminotransferase increased 46.65 11.14 482 292263 73794 29585939
Dehydration 46.43 11.14 889 291856 122650 29537083
Disseminated cryptococcosis 45.99 11.14 53 292692 956 29658777
B-cell lymphoma recurrent 45.98 11.14 43 292702 600 29659133
Pneumocystis jirovecii infection 45.77 11.14 61 292684 1284 29658449
Disturbance in attention 45.67 11.14 92 292653 22037 29637696
Joint stiffness 45.60 11.14 197 292548 9164 29650569
Nightmare 45.60 11.14 31 292714 12045 29647688
Drug eruption 45.30 11.14 63 292682 17463 29642270
Blood bilirubin increased 45.22 11.14 194 292551 36442 29623291
Osteopenia 44.95 11.14 123 292622 4525 29655208
Wrong technique in product usage process 44.87 11.14 155 292590 31000 29628733
Unresponsive to stimuli 44.77 11.14 122 292623 26297 29633436
Skin lesion 44.72 11.14 322 292423 18172 29641561
Malacoplakia 44.71 11.14 23 292722 108 29659625
Impaired work ability 44.65 11.14 139 292606 5504 29654229
Liver transplant rejection 44.07 11.14 78 292667 2120 29657613
Skin mass 44.00 11.14 102 292643 3380 29656353
Nephropathy toxic 43.74 11.14 213 292532 10426 29649307
Muscle rigidity 43.43 11.14 23 292722 10238 29649495
Cerebral haemorrhage 43.18 11.14 170 292575 32717 29627016
Psychotic disorder 43.09 11.14 91 292654 21424 29638309
Gamma-glutamyltransferase increased 42.97 11.14 145 292600 29205 29630528
Paranoia 42.88 11.14 23 292722 10165 29649568
Trichodysplasia spinulosa 42.69 11.14 27 292718 200 29659533
Steroid dependence 42.18 11.14 19 292726 62 29659671
Accidental overdose 42.13 11.14 71 292674 18204 29641529
Cognitive disorder 41.97 11.14 107 292638 23583 29636150
Pulmonary function test decreased 41.88 11.14 114 292631 4181 29655552
Human ehrlichiosis 41.62 11.14 26 292719 188 29659545
Myelodysplastic syndrome 41.46 11.14 320 292425 18458 29641275
Heart transplant rejection 41.38 11.14 56 292689 1197 29658536
Inflammation 40.94 11.14 361 292384 21665 29638068
Epstein-Barr virus associated lymphoproliferative disorder 40.85 11.14 66 292679 1662 29658071
Asthma-chronic obstructive pulmonary disease overlap syndrome 40.81 11.14 41 292704 628 29659105
Haematotoxicity 40.79 11.14 143 292602 6027 29653706
Nasopharyngitis 40.55 11.14 804 291941 58045 29601688
Hypofibrinogenaemia 40.50 11.14 64 292681 1581 29658152
Drug reaction with eosinophilia and systemic symptoms 40.18 11.14 143 292602 28345 29631388
Hepatosplenic T-cell lymphoma 39.97 11.14 35 292710 446 29659287
Weight decreased 39.86 11.14 1830 290915 149091 29510642
Abnormal dreams 39.34 11.14 15 292730 8100 29651633
Myocardial ischaemia 39.26 11.14 68 292677 17249 29642484
Renal graft infection 39.26 11.14 27 292718 234 29659499
Product substitution issue 38.92 11.14 25 292720 10010 29649723
Disseminated varicella zoster virus infection 38.79 11.14 48 292697 936 29658797
Melaena 38.67 11.14 174 292571 32263 29627470
Therapeutic response shortened 38.61 11.14 99 292646 3501 29656232
Influenza 38.45 11.14 617 292128 42781 29616952
Myoclonus 38.42 11.14 44 292701 13268 29646465
Tachycardia 37.98 11.14 500 292245 73239 29586494
Heart rate irregular 37.89 11.14 227 292518 12032 29647701
Eosinophil count abnormal 37.72 11.14 27 292718 251 29659482
Graft versus host disease in skin 37.62 11.14 93 292652 3214 29656519
Acanthamoeba infection 37.61 11.14 34 292711 453 29659280
Subdural haematoma 37.36 11.14 81 292664 18891 29640842
Memory impairment 37.16 11.14 212 292533 36962 29622771
Bronchial obstruction 37.13 11.14 58 292687 1418 29658315
Muscle spasms 37.02 11.14 430 292315 64408 29595325
Stenotrophomonas infection 37 11.14 61 292684 1563 29658170
Dermatophytosis 36.98 11.14 25 292720 210 29659523
Osteomyelitis fungal 36.97 11.14 24 292721 187 29659546
Transplant failure 36.89 11.14 78 292667 2426 29657307
Depressed mood 36.70 11.14 69 292676 16960 29642773
Epstein-Barr viraemia 36.62 11.14 45 292700 871 29658862
Body temperature fluctuation 36.38 11.14 53 292692 1216 29658517
Enterococcal infection 36.24 11.14 168 292577 8056 29651677
Acute myeloid leukaemia 36.03 11.14 300 292445 17706 29642027
Diabetes mellitus 35.90 11.14 592 292153 41273 29618460
End stage renal disease 35.86 11.14 156 292589 7279 29652454
Epilepsy 35.80 11.14 91 292654 20078 29639655
Sinusitis 35.77 11.14 490 292255 32855 29626878
Product quality issue 35.46 11.14 82 292663 18692 29641041
Hepatitis E 35.45 11.14 60 292685 1572 29658161
Pulmonary nocardiosis 35.11 11.14 30 292715 369 29659364
Meningitis listeria 35.06 11.14 29 292716 340 29659393
Product prescribing error 35.01 11.14 69 292676 16664 29643069
Balance disorder 34.94 11.14 211 292534 36282 29623451
Pericarditis fungal 34.89 11.14 22 292723 162 29659571
Therapeutic reaction time decreased 34.86 11.14 33 292712 468 29659265
Lymphoproliferative disorder 34.82 11.14 73 292672 2257 29657476
Pruritus 34.81 11.14 884 291861 117320 29542413
Mycobacterium marinum infection 34.70 11.14 25 292720 235 29659498
Human polyomavirus infection 34.55 11.14 37 292708 613 29659120
Lung hyperinflation 34.37 11.14 42 292703 808 29658925
Coronavirus infection 34.26 11.14 93 292652 3405 29656328
Mydriasis 33.96 11.14 9 292736 6134 29653599
Tremor 33.88 11.14 525 292220 74838 29584895
Mass 33.82 11.14 149 292596 6991 29652742
Drug level decreased 33.71 11.14 129 292616 5676 29654057
Cryptococcal cutaneous infection 33.70 11.14 17 292728 76 29659657
Amnesia 33.69 11.14 123 292622 24198 29635535
Klebsiella infection 33.60 11.14 145 292600 6742 29652991
Anaphylactic shock 33.53 11.14 53 292692 13940 29645793
Insomnia 33.43 11.14 677 292068 92659 29567074
Malignant transformation 33.43 11.14 38 292707 675 29659058
Steroid withdrawal syndrome 33.38 11.14 23 292722 200 29659533
Coccidioidomycosis 33.35 11.14 36 292709 602 29659131
Choroiditis 33.35 11.14 41 292704 794 29658939
Graft versus host disease 33.34 11.14 191 292554 9959 29649774
Visceral leishmaniasis 33.24 11.14 32 292713 464 29659269
Cytology abnormal 33.02 11.14 29 292716 371 29659362
Abdominal abscess 32.96 11.14 100 292645 3904 29655829
Diarrhoea 32.95 11.14 2815 289930 331288 29328445
Mobility decreased 32.95 11.14 394 292351 25605 29634128
Colectomy 32.93 11.14 55 292690 1425 29658308
Cat scratch disease 32.89 11.14 16 292729 65 29659668
Uveitis 32.87 11.14 123 292622 5354 29654379
Urinary retention 32.75 11.14 188 292557 32729 29627004
Myopathy 32.70 11.14 196 292549 10390 29649343
Cytomegalovirus gastrointestinal infection 32.61 11.14 19 292726 119 29659614
Status epilepticus 32.60 11.14 36 292709 11036 29648697
COVID-19 pneumonia 32.45 11.14 108 292637 4432 29655301
Squamous cell carcinoma 32.45 11.14 191 292554 10059 29649674
Labelled drug-drug interaction medication error 32.44 11.14 33 292712 10505 29649228
Hypogammaglobulinaemia 32.40 11.14 119 292626 5133 29654600
American trypanosomiasis 32.14 11.14 22 292723 189 29659544
Pneumonia pseudomonal 31.96 11.14 91 292654 3427 29656306
Smooth muscle cell neoplasm 31.90 11.14 17 292728 87 29659646
Scleroderma 31.80 11.14 51 292694 1276 29658457
Squamous cell carcinoma of skin 31.77 11.14 174 292571 8921 29650812
Night sweats 31.76 11.14 247 292498 14281 29645452
Diabetic ketoacidosis 31.69 11.14 68 292677 15918 29643815
Nasal obstruction 31.38 11.14 36 292709 646 29659087
Sinus bradycardia 31.28 11.14 41 292704 11654 29648079
Alcohol abuse 31.24 11.14 7 292738 5346 29654387
Pulmonary oedema 31.15 11.14 277 292468 43698 29616035
Periostitis 30.77 11.14 23 292722 230 29659503
Cerebral toxoplasmosis 30.50 11.14 53 292692 1419 29658314
Dystonia 30.47 11.14 30 292715 9697 29650036
Disseminated tuberculosis 30.42 11.14 65 292680 2037 29657696
Toxic epidermal necrolysis 30.28 11.14 83 292662 17857 29641876
Shock 30.11 11.14 118 292627 22741 29636992
Platelet count decreased 30.10 11.14 798 291947 105331 29554402
Delusion 30.09 11.14 44 292701 11945 29647788
Mantle cell lymphoma recurrent 29.70 11.14 28 292717 395 29659338
Hyperhidrosis 29.60 11.14 469 292276 66621 29593112
Pneumonia cryptococcal 29.56 11.14 36 292709 690 29659043
Superinfection bacterial 29.53 11.14 30 292715 466 29659267
Speech disorder 29.51 11.14 131 292614 24381 29635352
Eosinophilic granulomatosis with polyangiitis 29.43 11.14 49 292696 1266 29658467
Weight increased 29.42 11.14 949 291796 73964 29585769
Meningitis enterococcal 29.40 11.14 15 292730 69 29659664
T-cell lymphoma 29.28 11.14 41 292704 906 29658827
Ventricular remodelling 29.23 11.14 15 292730 70 29659663
Blood alkaline phosphatase increased 29.13 11.14 184 292561 31303 29628430
Salivary hypersecretion 29.13 11.14 19 292726 7547 29652186
Fistula 29.07 11.14 113 292632 5009 29654724
Fear 28.90 11.14 38 292707 10787 29648946
Vascular hyalinosis 28.82 11.14 11 292734 20 29659713
Vital capacity decreased 28.80 11.14 27 292718 378 29659355
Solar lentigo 28.77 11.14 25 292720 315 29659418
Tardive dyskinesia 28.75 11.14 7 292738 5050 29654683
Chest pain 28.69 11.14 903 291842 116724 29543009
B-cell lymphoma 28.51 11.14 103 292642 4407 29655326
Pneumonitis 28.46 11.14 401 292344 27053 29632680
Product dose omission issue 28.40 11.14 680 292065 90951 29568782
Myalgia 28.38 11.14 553 292192 76114 29583619
Parkinsonism 28.34 11.14 18 292727 7251 29652482
Chronic sinusitis 28.31 11.14 53 292692 1506 29658227
Lymphadenitis 28.20 11.14 56 292689 1664 29658069
Sudden death 28.20 11.14 69 292676 15423 29644310
Sarcoidosis 28.19 11.14 74 292671 2655 29657078
Blood immunoglobulin E increased 27.97 11.14 56 292689 1674 29658059
Herpes zoster cutaneous disseminated 27.97 11.14 19 292726 161 29659572
Herpes oesophagitis 27.96 11.14 15 292730 78 29659655
Granulocytopenia 27.79 11.14 13 292732 6213 29653520
Epidural lipomatosis 27.69 11.14 21 292724 215 29659518
Leukopenia 27.68 11.14 732 292013 55427 29604306
Staphylococcal infection 27.63 11.14 432 292313 29792 29629941
Hallucination, auditory 27.55 11.14 33 292712 9756 29649977
Pneumonia fungal 27.38 11.14 117 292628 5416 29654317
Prostate cancer 27.33 11.14 356 292389 23601 29636132
Cataract 27.27 11.14 330 292415 21505 29638228
Acquired haemophilia 27.25 11.14 36 292709 751 29658982
Peritoneal dialysis complication 27.09 11.14 4 292741 4123 29655610
Gastrointestinal haemorrhage 27.05 11.14 615 292130 82831 29576902
Enterovirus infection 26.99 11.14 31 292714 557 29659176
Defaecation urgency 26.94 11.14 50 292695 1411 29658322
Sporotrichosis 26.90 11.14 12 292733 38 29659695
Impaired quality of life 26.79 11.14 51 292694 1468 29658265
Cystitis haemorrhagic 26.67 11.14 105 292640 4682 29655051
Withdrawal syndrome 26.59 11.14 43 292702 11207 29648526
Psoriatic arthropathy 26.59 11.14 253 292492 15508 29644225
Encephalitis 26.56 11.14 129 292616 6307 29653426
Necrotising retinitis 26.41 11.14 34 292711 691 29659042
Adrenal insufficiency 26.36 11.14 184 292561 10279 29649454
Knee arthroplasty 26.29 11.14 117 292628 5513 29654220
Toxoplasmosis 26.26 11.14 41 292704 1002 29658731
Sexual dysfunction 26.07 11.14 13 292732 5988 29653745
Neutrophil count decreased 26.03 11.14 277 292468 42177 29617556
Diabetic cardiomyopathy 25.92 11.14 10 292735 19 29659714
Haemophagocytic lymphohistiocytosis 25.74 11.14 174 292571 9617 29650116
Head injury 25.66 11.14 83 292662 16937 29642796
Injury 25.65 11.14 117 292628 21614 29638119
Bradyphrenia 25.60 11.14 4 292741 3953 29655780
Cryptococcal fungaemia 25.48 11.14 14 292731 77 29659656
Poor venous access 25.36 11.14 67 292678 2413 29657320
Hiccups 25.30 11.14 33 292712 9401 29650332
Synovial cyst 25.29 11.14 54 292691 1691 29658042
Tendon rupture 25.25 11.14 136 292609 6928 29652805
Drug screen positive 25.25 11.14 6 292739 4401 29655332
Exposure during pregnancy 25.25 11.14 32 292713 9229 29650504
Plasmablastic lymphoma 25.20 11.14 21 292724 249 29659484
Primary effusion lymphoma 25.09 11.14 11 292734 33 29659700
Blood pressure decreased 25.04 11.14 317 292428 46758 29612975
Coombs positive haemolytic anaemia 24.97 11.14 34 292711 731 29659002
Pneumonia 24.96 11.14 3677 289068 330629 29329104
Arthritis bacterial 24.94 11.14 98 292647 4366 29655367
Mucous stools 24.90 11.14 38 292707 910 29658823
Medial tibial stress syndrome 24.82 11.14 9 292736 13 29659720
Hallucination, visual 24.69 11.14 78 292667 16035 29643698
Complications of transplanted lung 24.66 11.14 18 292727 173 29659560
Peripheral swelling 24.58 11.14 776 291969 60298 29599435
Inflammatory bowel disease 24.53 11.14 63 292682 2230 29657503
Muscle spasticity 24.47 11.14 10 292735 5178 29654555
Lipodystrophy acquired 24.44 11.14 3 292742 3557 29656176
Nasal oedema 24.42 11.14 23 292722 324 29659409
Cyanosis 24.30 11.14 50 292695 11885 29647848
Diaphragmatic hernia 24.21 11.14 21 292724 264 29659469
Obstructive nephropathy 24.10 11.14 10 292735 25 29659708
Systemic lupus erythematosus 24.08 11.14 67 292678 2489 29657244
Oropharyngeal pain 24.07 11.14 402 292343 28094 29631639
Listeria encephalitis 23.96 11.14 11 292734 38 29659695
Unevaluable event 23.95 11.14 197 292548 31588 29628145
Kaposi's sarcoma 23.94 11.14 39 292706 989 29658744
Product administration error 23.90 11.14 67 292678 14310 29645423
Graft versus host disease in gastrointestinal tract 23.73 11.14 75 292670 2994 29656739
Dysplastic naevus 23.70 11.14 23 292722 337 29659396
Hepatic encephalopathy 23.70 11.14 66 292679 14126 29645607
Physical disability 23.64 11.14 41 292704 1096 29658637
Epstein-Barr virus associated lymphoma 23.59 11.14 28 292717 522 29659211
Mycobacterium fortuitum infection 23.52 11.14 18 292727 187 29659546
Cerebral fungal infection 23.52 11.14 18 292727 187 29659546
Granulomatosis with polyangiitis 23.50 11.14 36 292709 865 29658868
Chorioretinopathy 23.48 11.14 47 292698 1405 29658328
Ventricular extrasystoles 23.42 11.14 48 292697 11426 29648307
Salmonellosis 23.33 11.14 32 292713 693 29659040
Tuberculosis of central nervous system 23.32 11.14 17 292728 163 29659570
Gastrointestinal inflammation 23.19 11.14 72 292673 2847 29656886
Hypothermia 23.15 11.14 36 292709 9531 29650202
Obsessive-compulsive disorder 23.02 11.14 6 292739 4135 29655598
Bacterial pyelonephritis 22.96 11.14 20 292725 253 29659480
Abscess 22.95 11.14 173 292572 9905 29649828
Hypomagnesaemia 22.95 11.14 84 292661 16514 29643219
Trichophytosis 22.92 11.14 21 292724 285 29659448
Scleritis 22.83 11.14 20 292725 255 29659478
Ventricular tachycardia 22.82 11.14 138 292607 23724 29636009
Ventricular fibrillation 22.69 11.14 74 292671 15064 29644669
Joint lock 22.66 11.14 39 292706 1036 29658697
Hyperglycaemia 22.61 11.14 476 292269 34724 29625009
Arrhythmia 22.59 11.14 211 292534 32958 29626775
Babesiosis 22.58 11.14 12 292733 61 29659672
Post transplant distal limb syndrome 22.52 11.14 20 292725 260 29659473
Poisoning deliberate 22.50 11.14 15 292730 5889 29653844
Lung consolidation 22.44 11.14 102 292643 4850 29654883
Dysgeusia 22.40 11.14 146 292599 24655 29635078
Tumour lysis syndrome 22.32 11.14 208 292537 12677 29647056
Necrotising oesophagitis 22.30 11.14 24 292721 400 29659333
Sinusitis bacterial 22.29 11.14 21 292724 296 29659437
Palpitations 22.26 11.14 215 292530 33358 29626375
Chronic lymphocytic leukaemia 22.24 11.14 97 292648 4531 29655202
Diverticular perforation 22.19 11.14 75 292670 3102 29656631
Mycobacterium haemophilum infection 22.11 11.14 9 292736 21 29659712
Obliterative bronchiolitis 22.09 11.14 41 292704 1157 29658576
Blood pressure increased 22.04 11.14 886 291859 71042 29588691
Inappropriate schedule of product administration 21.99 11.14 526 292219 39202 29620531
Bacterial sepsis 21.98 11.14 101 292644 4825 29654908
Lung infiltration 21.88 11.14 203 292542 12356 29647377
Pleocytosis 21.86 11.14 25 292720 447 29659286
Autoinflammatory disease 21.83 11.14 9 292736 22 29659711
Photodermatosis 21.79 11.14 24 292721 411 29659322
Gynaecomastia 21.60 11.14 30 292715 8321 29651412
Small for dates baby 21.32 11.14 3 292742 3205 29656528
Peritonitis bacterial 21.24 11.14 50 292695 11328 29648405
Nodule 21.24 11.14 98 292647 4690 29655043
Akathisia 21.18 11.14 16 292729 5888 29653845
Restrictive pulmonary disease 21.16 11.14 38 292707 1045 29658688
Hot flush 21.09 11.14 228 292517 14452 29645281
Emphysematous cystitis 21.06 11.14 10 292735 38 29659695
Rheumatoid lung 21.04 11.14 21 292724 319 29659414
Suspected suicide 20.90 11.14 3 292742 3158 29656575
Toxic skin eruption 20.89 11.14 48 292697 10967 29648766
Granuloma 20.88 11.14 61 292684 2331 29657402
Dust allergy 20.88 11.14 23 292722 394 29659339
Emphysematous pyelonephritis 20.87 11.14 10 292735 39 29659694
Lupus nephritis 20.85 11.14 19 292726 256 29659477
Neutrophilic dermatosis 20.78 11.14 17 292728 196 29659537
Disability 20.77 11.14 92 292653 4326 29655407
Lip swelling 20.74 11.14 60 292685 12684 29647049
Spinal instability 20.73 11.14 21 292724 325 29659408
Pulmonary fibrosis 20.66 11.14 242 292503 15648 29644085
Immunosuppressant drug level decreased 20.65 11.14 41 292704 1218 29658515
Hand deformity 20.60 11.14 52 292693 1821 29657912
Stomatitis 20.59 11.14 249 292496 37030 29622703
Symptom masked 20.57 11.14 24 292721 439 29659294
Tendon disorder 20.48 11.14 59 292686 2237 29657496
Acinetobacter infection 20.45 11.14 36 292709 974 29658759
Chondropathy 20.42 11.14 33 292712 831 29658902
Skin necrosis 20.42 11.14 96 292649 4631 29655102
Musculoskeletal pain 20.40 11.14 420 292325 30520 29629213
Muscle twitching 20.40 11.14 30 292715 8125 29651608
Disseminated Bacillus Calmette-Guerin infection 20.16 11.14 13 292732 100 29659633
Blood sodium decreased 20.16 11.14 83 292662 15773 29643960
Glomerulonephritis membranoproliferative 20.10 11.14 22 292723 374 29659359
Blood pressure diastolic increased 20.06 11.14 66 292679 2692 29657041
Lung disorder 20.03 11.14 425 292320 31044 29628689
Splenic lesion 20.02 11.14 14 292731 125 29659608
Hyperthermia 19.98 11.14 43 292702 10056 29649677
Central nervous system vasculitis 19.96 11.14 22 292723 377 29659356
Prescribed underdose 19.94 11.14 28 292717 7731 29652002
Bronchopulmonary aspergillosis allergic 19.93 11.14 20 292725 306 29659427
Pulmonary mucormycosis 19.91 11.14 23 292722 416 29659317
Rash maculo-papular 19.86 11.14 156 292589 25262 29634471
Hypertonia 19.81 11.14 9 292736 4376 29655357
Impaired healing 19.81 11.14 221 292524 14119 29645614
Atlantoaxial instability 19.62 11.14 20 292725 312 29659421
Synovitis 19.57 11.14 163 292582 9620 29650113
Spirometry abnormal 19.55 11.14 19 292726 279 29659454
Sleep disorder due to general medical condition, insomnia type 19.45 11.14 39 292706 1167 29658566
Appendiceal abscess 19.43 11.14 10 292735 47 29659686
Plasma cell myeloma 19.36 11.14 387 292358 53075 29606658
Glomerulonephritis minimal lesion 19.30 11.14 22 292723 392 29659341
Acquired apparent mineralocorticoid excess 19.28 11.14 8 292737 20 29659713
Intestinal perforation 19.27 11.14 146 292599 8373 29651360
Sopor 19.19 11.14 50 292695 10941 29648792
Somnambulism 19.17 11.14 4 292741 3210 29656523
Medication error 19.17 11.14 123 292622 20849 29638884
Wrist deformity 19.12 11.14 20 292725 322 29659411
Ileal stenosis 19.12 11.14 38 292707 1130 29658603
Chronic graft versus host disease in skin 19.11 11.14 29 292716 691 29659042
Anger 19.10 11.14 51 292694 11069 29648664
Lung abscess 19.09 11.14 61 292684 2450 29657283
Disease progression 19.03 11.14 959 291786 78915 29580818
Cytopenia 18.96 11.14 142 292603 8114 29651619
Pneumonia klebsiella 18.86 11.14 62 292683 2528 29657205
Body temperature decreased 18.85 11.14 160 292585 9495 29650238
Renal tubular necrosis 18.83 11.14 230 292515 15021 29644712
Mineral metabolism disorder 18.74 11.14 20 292725 330 29659403
Blood potassium increased 18.71 11.14 88 292657 16125 29643608
Ammonia increased 18.71 11.14 9 292736 4232 29655501
Lymphocele 18.70 11.14 43 292702 1417 29658316
Acute respiratory distress syndrome 18.69 11.14 328 292417 23144 29636589
Rheumatoid nodule 18.67 11.14 47 292698 1643 29658090
Small intestinal obstruction 18.64 11.14 210 292535 13449 29646284
Atrial fibrillation 18.62 11.14 865 291880 107259 29552474
Pancreas transplant rejection 18.62 11.14 15 292730 169 29659564
Transient ischaemic attack 18.61 11.14 157 292588 25043 29634690
Mycetoma mycotic 18.61 11.14 9 292736 36 29659697
Dysphagia 18.61 11.14 417 292328 56281 29603452
Wrong product administered 18.61 11.14 11 292734 4607 29655126
Complications of transplanted heart 18.54 11.14 17 292728 231 29659502
Transitional cell carcinoma 18.51 11.14 52 292693 1943 29657790
Therapy non-responder 18.50 11.14 397 292348 29056 29630677
Drug abuser 18.43 11.14 10 292735 4391 29655342
Erythema multiforme 18.43 11.14 31 292714 7954 29651779
Mycobacterium chelonae infection 18.42 11.14 26 292719 579 29659154
Complications of transplant surgery 18.41 11.14 24 292721 494 29659239
Dislocation of vertebra 18.39 11.14 21 292724 375 29659358
Epstein Barr virus positive mucocutaneous ulcer 18.36 11.14 17 292728 234 29659499
Blood urea increased 18.34 11.14 207 292538 31174 29628559
Angina pectoris 18.33 11.14 192 292553 29326 29630407
Abscess intestinal 18.29 11.14 42 292703 1383 29658350
Oxalosis 18.25 11.14 8 292737 24 29659709
Intervertebral disc space narrowing 18.23 11.14 27 292718 629 29659104
Listeriosis 18.23 11.14 32 292713 864 29658869
Infectious thyroiditis 18.23 11.14 12 292733 96 29659637
Priapism 18.14 11.14 12 292733 4731 29655002
Ankle deformity 18.14 11.14 16 292729 206 29659527
Refractory cytopenia with unilineage dysplasia 18.11 11.14 23 292722 461 29659272
Pneumonia necrotising 18.09 11.14 24 292721 503 29659230
Central nervous system infection 17.96 11.14 23 292722 465 29659268
Mental impairment 17.94 11.14 40 292705 9237 29650496
Emotional distress 17.94 11.14 86 292659 15679 29644054
Escherichia sepsis 17.90 11.14 82 292663 3912 29655821
Acute promyelocytic leukaemia 17.90 11.14 25 292720 551 29659182
Asphyxia 17.85 11.14 16 292729 5409 29654324
Cardiomegaly 17.79 11.14 77 292668 14432 29645301
Orbital myositis 17.78 11.14 11 292734 78 29659655
Bronchial disorder 17.77 11.14 32 292713 882 29658851
Viraemia 17.69 11.14 37 292708 1142 29658591
Cardiac perforation 17.67 11.14 11 292734 79 29659654
Heart rate decreased 17.67 11.14 296 292449 20698 29639035
Epstein-Barr virus test positive 17.66 11.14 24 292721 515 29659218
Zoonotic bacterial infection 17.64 11.14 10 292735 59 29659674
Pyrexia 17.64 11.14 3201 289544 291288 29368445
Corynebacterium infection 17.63 11.14 21 292724 393 29659340
Muscle swelling 17.60 11.14 20 292725 355 29659378
Euphoric mood 17.60 11.14 10 292735 4280 29655453
Pancreatic carcinoma 17.56 11.14 31 292714 7806 29651927
Granulomatous dermatitis 17.53 11.14 16 292729 216 29659517
Mycobacterium abscessus infection 17.50 11.14 25 292720 563 29659170
Aspergilloma 17.50 11.14 19 292726 320 29659413
Glycosylated haemoglobin increased 17.49 11.14 42 292703 9449 29650284
Presyncope 17.46 11.14 89 292656 15967 29643766
Renal failure 17.46 11.14 1057 291688 127909 29531824
Blood triglycerides increased 17.43 11.14 74 292671 13943 29645790
Myelosuppression 17.42 11.14 127 292618 7195 29652538
Emphysema 17.42 11.14 154 292591 9248 29650485
Colectomy total 17.35 11.14 12 292733 105 29659628
Oral candidiasis 17.35 11.14 175 292570 10896 29648837
Hypernatraemia 17.32 11.14 29 292716 7455 29652278
Azoospermia 17.30 11.14 21 292724 401 29659332
Atrioventricular block first degree 17.30 11.14 18 292727 5670 29654063
Upper-airway cough syndrome 17.22 11.14 62 292683 2648 29657085
Acne 17.19 11.14 154 292591 9282 29650451
Blood stem cell transplant failure 17.19 11.14 21 292724 404 29659329
Anaemia 17.07 11.14 1776 290969 206216 29453517
Chromoblastomycosis 17.06 11.14 9 292736 45 29659688
Fear of injection 17.02 11.14 26 292719 623 29659110
Lymph node calcification 17.01 11.14 15 292730 193 29659540
Haemorrhagic stroke 17.01 11.14 21 292724 6126 29653607
Vasculitis 17.00 11.14 135 292610 7855 29651878
Acute lymphocytic leukaemia recurrent 16.93 11.14 61 292684 2606 29657127
Swollen tongue 16.80 11.14 69 292676 13123 29646610
Endophthalmitis 16.77 11.14 73 292672 3407 29656326
Phospholipidosis 16.75 11.14 9 292736 47 29659686
Fluoride increased 16.75 11.14 9 292736 47 29659686
Orf 16.73 11.14 7 292738 18 29659715
Electrolyte imbalance 16.70 11.14 57 292688 11443 29648290
Apnoea 16.67 11.14 22 292723 6236 29653497
Intracranial pressure increased 16.66 11.14 73 292672 3417 29656316
Neuroendocrine carcinoma of the skin 16.64 11.14 25 292720 590 29659143
Cytomegalovirus nephritis 16.64 11.14 12 292733 113 29659620
Hydronephrosis 16.57 11.14 147 292598 8836 29650897
Drug intolerance 16.55 11.14 569 292176 44722 29615011
Diabetic metabolic decompensation 16.54 11.14 39 292706 1307 29658426
Ataxia 16.52 11.14 57 292688 11405 29648328
Cutaneous tuberculosis 16.51 11.14 11 292734 90 29659643
Necrotising herpetic retinopathy 16.47 11.14 7 292738 19 29659714
Pericarditis infective 16.45 11.14 9 292736 49 29659684
Rabies 16.42 11.14 6 292739 9 29659724
Haematochezia 16.26 11.14 444 292301 33778 29625955
Forced vital capacity decreased 16.26 11.14 28 292717 744 29658989
Lung opacity 16.25 11.14 30 292715 843 29658890
Acarodermatitis 16.22 11.14 19 292726 349 29659384
Empyema 16.20 11.14 63 292682 2793 29656940
Road traffic accident 16.18 11.14 99 292646 16972 29642761
Eye abscess 16.17 11.14 13 292732 146 29659587
Colostomy 16.16 11.14 20 292725 390 29659343
Mantle cell lymphoma 16.14 11.14 42 292703 1499 29658234
Exposure via ingestion 16.10 11.14 3 292742 2608 29657125
Cytomegalovirus chorioretinitis 16.09 11.14 69 292676 3199 29656534
Acute febrile neutrophilic dermatosis 16.08 11.14 35 292710 1111 29658622
Tuberculosis gastrointestinal 16.06 11.14 15 292730 209 29659524
Hyperlactacidaemia 16.05 11.14 3 292742 2603 29657130
Meningoencephalitis amoebic 16.05 11.14 12 292733 120 29659613
Polymyalgia rheumatica 16.05 11.14 34 292711 1059 29658674
Necrotising fasciitis fungal 16.04 11.14 6 292739 10 29659723
Respiratory disorder 15.97 11.14 250 292495 17244 29642489
Bronchitis 15.96 11.14 498 292247 38627 29621106
Acute erythroid leukaemia 15.95 11.14 13 292732 149 29659584
Pyogenic granuloma 15.94 11.14 15 292730 211 29659522
Colour blindness acquired 15.93 11.14 10 292735 73 29659660
Eschar 15.90 11.14 24 292721 569 29659164
Staphylococcal bacteraemia 15.88 11.14 117 292628 6651 29653082
Neurocryptococcosis 15.87 11.14 5 292740 3 29659730
Tuberculosis 15.85 11.14 134 292611 7943 29651790
Osteomyelitis 15.85 11.14 216 292529 14465 29645268
Urinary tract infection bacterial 15.83 11.14 41 292704 1459 29658274
Histology abnormal 15.81 11.14 17 292728 283 29659450
Mucocutaneous leishmaniasis 15.76 11.14 9 292736 54 29659679
Varicella zoster pneumonia 15.76 11.14 9 292736 54 29659679
Lip ulceration 15.72 11.14 28 292717 765 29658968
Sinus node dysfunction 15.70 11.14 9 292736 3834 29655899
Carotid artery aneurysm 15.65 11.14 8 292737 37 29659696
Red blood cell count decreased 15.62 11.14 173 292572 26148 29633585
Drooling 15.52 11.14 5 292740 3000 29656733
BK polyomavirus test positive 15.50 11.14 7 292738 23 29659710
Splenic marginal zone lymphoma 15.48 11.14 8 292737 38 29659695
Atrial septal defect 15.48 11.14 26 292719 6675 29653058
Psychomotor hyperactivity 15.47 11.14 36 292709 8188 29651545
Lower respiratory tract congestion 15.44 11.14 32 292713 981 29658752
Gastrointestinal fistula 15.44 11.14 17 292728 291 29659442
Anaphylactic reaction 15.41 11.14 187 292558 27795 29631938
Metapneumovirus infection 15.34 11.14 23 292722 542 29659191
Combined immunodeficiency 15.29 11.14 5 292740 4 29659729
Mitochondrial toxicity 15.26 11.14 3 292742 2511 29657222
Bacteraemia 15.22 11.14 225 292520 15335 29644398
Acute pulmonary histoplasmosis 15.19 11.14 10 292735 80 29659653
Pain 15.19 11.14 1918 290827 170723 29489010
Opportunistic infection 15.18 11.14 37 292708 1267 29658466
Diarrhoea haemorrhagic 15.16 11.14 103 292642 5702 29654031
Dermatitis acneiform 15.16 11.14 20 292725 5669 29654064
Pneumonia viral 15.14 11.14 59 292686 2618 29657115
Tongue disorder 15.14 11.14 12 292733 4310 29655423
Hyperammonaemia 15.12 11.14 19 292726 5501 29654232
Pneumonia acinetobacter 15.12 11.14 9 292736 59 29659674
Reversible airways obstruction 15.04 11.14 16 292729 263 29659470
Blood test abnormal 15.01 11.14 99 292646 5426 29654307
Ketoacidosis 14.99 11.14 9 292736 3737 29655996
Blood cholesterol 14.96 11.14 11 292734 107 29659626
Bone marrow reticulin fibrosis 14.95 11.14 13 292732 164 29659569
Myasthenic syndrome 14.94 11.14 18 292727 341 29659392
Dry mouth 14.86 11.14 147 292598 22703 29637030
Device occlusion 14.84 11.14 23 292722 6097 29653636
Glomerulonephropathy 14.80 11.14 11 292734 109 29659624
Thyroid gland abscess 14.76 11.14 9 292736 62 29659671
Nephritis haemorrhagic 14.74 11.14 6 292739 14 29659719
Hepatitis viral 14.73 11.14 21 292724 472 29659261
Prerenal failure 14.72 11.14 46 292699 1825 29657908
Glomerulosclerosis 14.71 11.14 25 292720 657 29659076
Bladder cancer 14.70 11.14 43 292702 9059 29650674
Pulmonary sarcoidosis 14.70 11.14 23 292722 563 29659170
Blood immunoglobulin G decreased 14.69 11.14 30 292715 910 29658823
Abdominal wall abscess 14.67 11.14 21 292724 474 29659259
Viral infection 14.63 11.14 219 292526 14966 29644767
Morphoea 14.62 11.14 12 292733 139 29659594
Incision site pain 14.61 11.14 48 292697 1956 29657777
Hypokalaemia 14.58 11.14 376 292369 49816 29609917
Gait disturbance 14.57 11.14 590 292155 74187 29585546
Erysipelothrix infection 14.55 11.14 4 292741 0 29659733
Respiratory fume inhalation disorder 14.55 11.14 4 292741 0 29659733
Foetal exposure during pregnancy 14.55 11.14 263 292482 36608 29623125
Disseminated varicella zoster vaccine virus infection 14.42 11.14 8 292737 45 29659688
Reactive gastropathy 14.33 11.14 13 292732 174 29659559
Lethargy 14.33 11.14 286 292459 39233 29620500
Prophylaxis against transplant rejection 14.29 11.14 7 292738 29 29659704
Traumatic lung injury 14.27 11.14 34 292711 1147 29658586
Coronary arterial stent insertion 14.25 11.14 12 292733 4182 29655551
Immunodeficiency 14.23 11.14 81 292664 4213 29655520
Intestinal stenosis 14.23 11.14 46 292699 1859 29657874
Haemolysis 14.21 11.14 120 292625 7111 29652622
Blood stem cell harvest failure 14.19 11.14 6 292739 16 29659717
Histoplasmosis cutaneous 14.19 11.14 6 292739 16 29659717
Renal transplant 14.11 11.14 44 292701 1744 29657989
Laryngeal mass 14.10 11.14 7 292738 30 29659703
Epidermodysplasia verruciformis 14.10 11.14 7 292738 30 29659703
Chronic myelomonocytic leukaemia 14.09 11.14 24 292721 632 29659101
Postoperative wound infection 14.09 11.14 83 292662 4372 29655361
Herpes simplex encephalitis 14.08 11.14 16 292729 284 29659449
Mood altered 14.05 11.14 38 292707 8212 29651521
Eosinophil count 14.01 11.14 11 292734 119 29659614
Lymphoma 13.99 11.14 156 292589 9965 29649768
Sweat gland tumour 13.97 11.14 19 292726 408 29659325
Peripheral arterial occlusive disease 13.94 11.14 18 292727 5150 29654583
Pericardial fibrosis 13.93 11.14 7 292738 31 29659702
Anhedonia 13.91 11.14 39 292706 8330 29651403
Generalised tonic-clonic seizure 13.91 11.14 123 292622 19428 29640305
Incorrect route of product administration 13.91 11.14 60 292685 11255 29648478
Cutaneous sporotrichosis 13.88 11.14 5 292740 7 29659726
Drug level abnormal 13.88 11.14 9 292736 70 29659663
Clostridium difficile colitis 13.84 11.14 188 292557 12580 29647153
Drug resistance 13.83 11.14 275 292470 19858 29639875
Pancytopenia 13.80 11.14 987 291758 84065 29575668
Ophthalmic herpes zoster 13.77 11.14 24 292721 644 29659089
Blood bilirubin decreased 13.75 11.14 15 292730 254 29659479
Necrotising soft tissue infection 13.74 11.14 8 292737 50 29659683
Atrioventricular block complete 13.73 11.14 40 292705 8437 29651296
Walking aid user 13.70 11.14 38 292707 1409 29658324
Human herpes virus 8 test positive 13.69 11.14 6 292739 18 29659715
Candida osteomyelitis 13.69 11.14 6 292739 18 29659715
Sudden cardiac death 13.68 11.14 10 292735 3742 29655991
Blood potassium decreased 13.61 11.14 101 292644 16561 29643172
Pneumonia legionella 13.56 11.14 40 292705 1537 29658196
Aphasia 13.52 11.14 123 292622 19316 29640417
Chemical peritonitis 13.51 11.14 11 292734 126 29659607
Meningitis haemophilus 13.49 11.14 5 292740 8 29659725
Limb deformity 13.47 11.14 20 292725 467 29659266
Renal tubular injury 13.47 11.14 23 292722 607 29659126
Application site erythema 13.46 11.14 3 292742 2300 29657433
Allergy to animal 13.45 11.14 12 292733 157 29659576
Rhinalgia 13.43 11.14 18 292727 381 29659352
Ventricular septal defect 13.40 11.14 9 292736 3520 29656213
Hepatic steatosis 13.40 11.14 87 292658 14706 29645027
Neurosarcoidosis 13.39 11.14 12 292733 158 29659575
Upper gastrointestinal haemorrhage 13.39 11.14 144 292601 21884 29637849
Chronic lymphocytic leukaemia refractory 13.38 11.14 10 292735 100 29659633
Sebaceous hyperplasia 13.37 11.14 8 292737 53 29659680
Chromaturia 13.35 11.14 80 292665 13785 29645948
Renal cell carcinoma stage I 13.23 11.14 6 292739 20 29659713
Muscle abscess 13.22 11.14 20 292725 475 29659258
Cold sweat 13.20 11.14 45 292700 9037 29650696
Serum sickness 13.17 11.14 43 292702 1747 29657986
Lip squamous cell carcinoma 13.09 11.14 9 292736 78 29659655
Enterocolonic fistula 13.09 11.14 9 292736 78 29659655
Enthesopathy 13.08 11.14 6 292739 2900 29656833
Disseminated intravascular coagulation 13.05 11.14 146 292599 22025 29637708
Renal impairment 13.02 11.14 681 292064 83503 29576230
Skin papilloma 13.01 11.14 41 292704 1634 29658099
Choriomeningitis lymphocytic 13.01 11.14 6 292739 21 29659712
Chronic granulomatous disease 13.01 11.14 6 292739 21 29659712
Aphthous ulcer 13 11.14 77 292668 4064 29655669
Retroperitoneal lymphadenopathy 12.99 11.14 24 292721 675 29659058
Mycoplasma infection 12.96 11.14 15 292730 272 29659461
Chronic obstructive pulmonary disease 12.95 11.14 563 292182 45563 29614170
Drug level above therapeutic 12.92 11.14 60 292685 2879 29656854
Prothrombin time prolonged 12.91 11.14 47 292698 9256 29650477
Vascular injury 12.91 11.14 15 292730 273 29659460
Nodular regenerative hyperplasia 12.91 11.14 25 292720 729 29659004
Meningoencephalitis viral 12.90 11.14 10 292735 106 29659627
Large intestinal ulcer 12.85 11.14 41 292704 1645 29658088
Cutaneous mucormycosis 12.81 11.14 7 292738 38 29659695
Vertebroplasty 12.81 11.14 7 292738 38 29659695
Diaphragm muscle weakness 12.81 11.14 9 292736 81 29659652
Cholangitis sclerosing 12.80 11.14 28 292717 892 29658841
Renal cell carcinoma stage III 12.79 11.14 5 292740 10 29659723
Bone marrow tumour cell infiltration 12.79 11.14 5 292740 10 29659723
Meningitis noninfective 12.79 11.14 5 292740 10 29659723
Chronic kidney disease 12.78 11.14 277 292468 37561 29622172
Liver injury 12.78 11.14 70 292675 12330 29647403
Social avoidant behaviour 12.74 11.14 6 292739 2857 29656876
Prescribed overdose 12.73 11.14 42 292703 8519 29651214
Polyomavirus viraemia 12.71 11.14 20 292725 492 29659241
Peripheral sensory neuropathy 12.71 11.14 100 292645 5801 29653932
Pancreatic carcinoma metastatic 12.71 11.14 8 292737 3239 29656494
Anal abscess 12.68 11.14 89 292656 4980 29654753
Post procedural diarrhoea 12.68 11.14 8 292737 59 29659674
Ischaemic stroke 12.66 11.14 100 292645 16175 29643558
Skin induration 12.63 11.14 49 292696 2170 29657563
Respiratory tract infection fungal 12.62 11.14 23 292722 640 29659093
Encephalopathy 12.61 11.14 230 292515 31975 29627758
Cryptitis 12.60 11.14 6 292739 23 29659710
Juvenile idiopathic arthritis 12.58 11.14 30 292715 1013 29658720
Clear cell renal cell carcinoma 12.57 11.14 28 292717 903 29658830
Vertigo 12.57 11.14 151 292594 22484 29637249
Petit mal epilepsy 12.53 11.14 5 292740 2626 29657107
Multiple sclerosis relapse 12.51 11.14 59 292686 10803 29648930
Urinoma 12.49 11.14 13 292732 208 29659525
Pseudarthrosis 12.48 11.14 5 292740 11 29659722
Ill-defined disorder 12.47 11.14 157 292588 10327 29649406
Maternal drugs affecting foetus 12.46 11.14 14 292731 4259 29655474
Sinus congestion 12.46 11.14 84 292661 4638 29655095
Ulcer 12.46 11.14 111 292634 6680 29653053
Arteriospasm coronary 12.43 11.14 5 292740 2613 29657120
Retinitis 12.42 11.14 15 292730 285 29659448
Angina unstable 12.41 11.14 70 292675 12240 29647493
Hepatosplenomegaly 12.39 11.14 70 292675 3631 29656102
Nasal disorder 12.35 11.14 32 292713 1139 29658594
Pulmonary cavitation 12.34 11.14 24 292721 702 29659031
Endocarditis Q fever 12.34 11.14 4 292741 3 29659730
Cutaneous blastomycosis 12.34 11.14 4 292741 3 29659730
Peripheral nerve palsy 12.34 11.14 4 292741 3 29659730
Quadriplegia 12.32 11.14 38 292707 1497 29658236
Secondary immunodeficiency 12.25 11.14 16 292729 330 29659403
Ileal ulcer 12.25 11.14 21 292724 556 29659177
Atypical mycobacterial pneumonia 12.25 11.14 10 292735 115 29659618
Transitional cell carcinoma metastatic 12.22 11.14 6 292739 25 29659708
Diffuse vasculitis 12.22 11.14 6 292739 25 29659708
Myiasis 12.19 11.14 5 292740 12 29659721
Biliary hamartoma 12.19 11.14 5 292740 12 29659721
Toxic optic neuropathy 12.15 11.14 23 292722 659 29659074
Mucosal inflammation 12.14 11.14 387 292358 30107 29629626
Chronic lymphocytic leukaemia recurrent 12.13 11.14 18 292727 420 29659313
Perirectal abscess 12.11 11.14 38 292707 1511 29658222
Lupus-like syndrome 12.11 11.14 47 292698 2082 29657651
Thrombotic microangiopathy 12.03 11.14 133 292612 8477 29651256
Blindness cortical 11.99 11.14 15 292730 296 29659437
Middle insomnia 11.98 11.14 97 292648 5676 29654057
Colitis ischaemic 11.98 11.14 24 292721 5762 29653971
Breath sounds abnormal 11.97 11.14 86 292659 4849 29654884
Oesophageal infection 11.97 11.14 13 292732 219 29659514
Pneumonia herpes viral 11.96 11.14 9 292736 91 29659642
Abdominal lymphadenopathy 11.95 11.14 20 292725 519 29659214
Total lung capacity abnormal 11.93 11.14 12 292733 184 29659549
Atrioventricular block second degree 11.93 11.14 8 292737 3132 29656601
Pneumonia escherichia 11.93 11.14 16 292729 339 29659394
Herpes simplex colitis 11.91 11.14 5 292740 13 29659720
Protein C decreased 11.91 11.14 5 292740 13 29659720
Gastroenteritis sapovirus 11.90 11.14 10 292735 120 29659613
Intestinal fistula 11.90 11.14 25 292720 774 29658959
Ureaplasma infection 11.88 11.14 12 292733 185 29659548
Bronchoscopy abnormal 11.87 11.14 7 292738 45 29659688
Urinary incontinence 11.86 11.14 107 292638 16833 29642900
Tongue necrosis 11.86 11.14 6 292739 27 29659706
Nocardia sepsis 11.82 11.14 4 292741 4 29659729
Nystagmus 11.81 11.14 15 292730 4323 29655410
Upper respiratory tract infection 11.81 11.14 352 292393 27124 29632609
Chronic spontaneous urticaria 11.80 11.14 9 292736 93 29659640
Haematocrit decreased 11.79 11.14 220 292525 30479 29629254
Microscopic polyangiitis 11.77 11.14 10 292735 122 29659611
Musculoskeletal disorder 11.74 11.14 85 292660 4804 29654929
Polychondritis 11.73 11.14 11 292734 154 29659579
Infection parasitic 11.72 11.14 9 292736 94 29659639
Pneumoperitoneum 11.71 11.14 39 292706 1601 29658132
Bronchial wall thickening 11.70 11.14 18 292727 434 29659299
Unmasking of previously unidentified disease 11.70 11.14 21 292724 577 29659156
Lymphocyte count abnormal 11.70 11.14 21 292724 577 29659156
Haematuria 11.69 11.14 341 292404 44493 29615240
Respiratory tract congestion 11.69 11.14 93 292652 5413 29654320
Gastroenteritis cryptosporidial 11.68 11.14 12 292733 189 29659544
Myasthenia gravis 11.66 11.14 59 292686 2933 29656800
Renal cancer stage I 11.65 11.14 5 292740 14 29659719
Donor specific antibody present 11.65 11.14 9 292736 95 29659638
Central nervous system lesion 11.62 11.14 85 292660 4821 29654912
Cutaneous T-cell lymphoma 11.61 11.14 34 292711 1301 29658432
Skin atrophy 11.60 11.14 39 292706 1609 29658124
Cutaneous nocardiosis 11.57 11.14 9 292736 96 29659637
Osteomyelitis acute 11.56 11.14 11 292734 157 29659576
Microsporidia infection 11.55 11.14 21 292724 583 29659150
Malignant melanoma 11.54 11.14 117 292628 7294 29652439
Cryoglobulinaemia 11.53 11.14 15 292730 308 29659425
Pancreatitis acute 11.53 11.14 179 292566 25516 29634217
Bronchiolitis 11.53 11.14 51 292694 2397 29657336
Obstruction 11.52 11.14 34 292711 1307 29658426
Diabetic neuropathy 11.52 11.14 13 292732 3946 29655787
Jejunal perforation 11.44 11.14 12 292733 194 29659539
Electrocardiogram QRS complex prolonged 11.43 11.14 15 292730 4262 29655471
Dementia 11.43 11.14 73 292672 12388 29647345
Bacteroides infection 11.42 11.14 9 292736 98 29659635
Pulmonary function test increased 11.40 11.14 5 292740 15 29659718
Leukocytosis 11.39 11.14 283 292462 21219 29638514
Alcohol poisoning 11.35 11.14 12 292733 3752 29655981
Painful respiration 11.33 11.14 33 292712 1259 29658474
Salmonella bacteraemia 11.32 11.14 10 292735 129 29659604
Actinic keratosis 11.31 11.14 67 292678 3536 29656197
Syringe issue 11.30 11.14 7 292738 2858 29656875
Meningitis candida 11.30 11.14 8 292737 73 29659660
Eye infection fungal 11.28 11.14 15 292730 315 29659418
Cardiac sarcoidosis 11.27 11.14 7 292738 50 29659683
Gastrosplenic fistula 11.22 11.14 6 292739 31 29659702
Vocal cord dysfunction 11.18 11.14 11 292734 164 29659569
Skin ulcer 11.18 11.14 252 292493 18597 29641136
Sebaceous adenoma 11.17 11.14 5 292740 16 29659717
Exophthalmos 11.16 11.14 19 292726 500 29659233

Pharmacologic Action:

SourceCodeDescription
ATC A07EA03 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC H02AB07 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:35705 immunosuppressant
CHEBI has role CHEBI:37962 adrenergic neuron agents
CHEBI has role CHEBI:50266 prodrugs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Thyroiditis indication 82119001 DOID:7166
Autoimmune disease indication 85828009
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Acute lymphoid leukemia indication 91857003 DOID:9952
Chronic lymphoid leukemia, disease indication 92814006
Disorder of skin indication 95320005 DOID:37
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Asthma indication 195967001 DOID:2841
Transplanted organ rejection indication 213148006
Adrenogenital disorder indication 267395000 DOID:0050811
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Prevention of Transplant Rejection indication
Erythroblastic Anemia indication
Systemic Dermatomyositis indication
Diffuse Proliferative Lupus Nephritis indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Pemphigoid off-label use 86142006
Myasthenia gravis off-label use 91637004 DOID:437
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Bell's palsy off-label use 193093009 DOID:12506
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Pure Red Cell Aplasia associated with Chronic Lymphocytic Leukemia off-label use
Metastatic Prostate Carcinoma off-label use
Neuroendocrine Prostate Carcinoma off-label use
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Cluster Headache Prevention off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Pregnancy, function contraindication 289908002
Varicella-zoster virus infection contraindication 309465005
Osteopenia contraindication 312894000
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.33 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8 WOMBAT-PK CHEMBL
Sodium/nucleoside cotransporter 1 Transporter Ki 5.77 DRUG MATRIX
Annexin A1 Cytosolic other WOMBAT-PK

External reference:

IDSource
4017876 VUID
N0000146229 NUI
D00473 KEGG_DRUG
4017876 VANDF
C0032952 UMLSCUI
CHEBI:8382 CHEBI
PDN PDB_CHEM_ID
5865 PUBCHEM_CID
DB00635 DRUGBANK_ID
CHEMBL635 ChEMBL_ID
D011241 MESH_DESCRIPTOR_UI
7096 IUPHAR_LIGAND_ID
536 INN_ID
VB0R961HZT UNII
8640 RXNORM
287 MMSL
5351 MMSL
72025 MMSL
d00350 MMSL
002164 NDDF
10312003 SNOMEDCT_US
116602009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0017 TABLET 10 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0018 TABLET 20 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0019 TABLET 50 mg ORAL ANDA 10 sections
PredniSONE Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3721 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-3722 SOLUTION 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4728 TABLET 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4741 TABLET 1 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4742 TABLET 2.50 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8724 TABLET 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8739 TABLET 1 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8740 TABLET 2.50 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-9817 TABLET 10 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-9818 TABLET 20 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-9828 TABLET 5 mg ORAL ANDA 10 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9738 TABLET 20 mg ORAL ANDA 18 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9739 TABLET 10 mg ORAL ANDA 18 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9740 TABLET 5 mg ORAL ANDA 18 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0640 TABLET 5 mg ORAL ANDA 21 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0641 TABLET 10 mg ORAL ANDA 21 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0642 TABLET 20 mg ORAL ANDA 21 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0440-8165 TABLET 5 mg ORAL ANDA 14 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0440-8167 TABLET 20 mg ORAL ANDA 14 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0463-6141 TABLET 20 mg ORAL ANDA 20 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0463-6155 TABLET 5 mg ORAL ANDA 20 sections
PREDNISONE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2930 TABLET 1 mg ORAL ANDA 10 sections
PREDNISONE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2931 TABLET 2.50 mg ORAL ANDA 13 sections
PREDNISONE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2932 TABLET 5 mg ORAL ANDA 13 sections
PREDNISONE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2933 TABLET 10 mg ORAL ANDA 13 sections
PREDNISONE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2934 TABLET 20 mg ORAL ANDA 13 sections
PREDNISONE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2935 TABLET 50 mg ORAL ANDA 13 sections