prednisone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2253 53-03-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednisone anhydrous
  • prednisone
  • 1,2-dehydrocortisone
  • dehydrocortisone
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
  • Molecular weight: 358.43
  • Formula: C21H26O5
  • CLOGP: 1.66
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 91.67
  • ALOGS: -3.51
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.12 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 3 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 7.97 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.57 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.27 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 21, 1955 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1901.88 11.41 7742 870364 246077 62364839
Completed suicide 1613.56 11.41 101 878005 145572 62465344
Drug ineffective 1499.44 11.41 21444 856662 1023321 61587595
Death 971.32 11.41 2356 875750 372025 62238891
Toxicity to various agents 957.45 11.41 1208 876898 246042 62364874
Joint swelling 827.38 11.41 7524 870582 320142 62290774
Contraindicated product administered 767.97 11.41 5398 872708 212250 62398666
Intentional overdose 697.97 11.41 98 878008 74054 62536862
Systemic lupus erythematosus 663.28 11.41 5053 873053 203865 62407051
Treatment failure 641.29 11.41 4831 873275 194212 62416704
Overdose 615.53 11.41 418 877688 114660 62496256
Arthralgia 614.72 11.41 11173 866933 558537 62052379
Drug abuse 581.86 11.41 143 877963 72375 62538541
Pemphigus 567.57 11.41 4416 873690 179310 62431606
Therapeutic product effect incomplete 564.19 11.41 3302 874804 121754 62489162
Constipation 550.41 11.41 1457 876649 223486 62387430
Asthma 549.09 11.41 3327 874779 124234 62486682
Condition aggravated 539.21 11.41 8176 869930 394041 62216875
Off label use 538.50 11.41 12652 865454 661810 61949106
Colitis ulcerative 534.84 11.41 1142 876964 24949 62585967
Arthropathy 505.85 11.41 5217 872889 229575 62381341
Drug interaction 478.35 11.41 1598 876508 227533 62383383
Electrocardiogram QT prolonged 472.53 11.41 120 877986 59410 62551506
Depressed level of consciousness 466.79 11.41 139 877967 61939 62548977
Swelling 458.34 11.41 5819 872287 269559 62341357
Therapeutic product effect decreased 456.42 11.41 4376 873730 188811 62422105
Loss of personal independence in daily activities 442.66 11.41 2575 875531 94715 62516201
Drug intolerance 442.09 11.41 6348 871758 302313 62308603
Hyponatraemia 440.72 11.41 539 877567 111361 62499555
Suicide attempt 435.68 11.41 149 877957 60769 62550147
Glossodynia 429.53 11.41 4066 874040 174810 62436106
Acute kidney injury 419.35 11.41 2044 876062 261371 62349545
Post transplant lymphoproliferative disorder 419.16 11.41 428 877678 4603 62606313
Pain 413.63 11.41 13269 864837 727359 61883557
Bradycardia 410.58 11.41 252 877854 72975 62537941
Wheezing 403.46 11.41 2481 875625 93114 62517802
Hand deformity 402.62 11.41 3664 874442 155793 62455123
Fall 390.18 11.41 3508 874598 388826 62222090
Hypotension 383.36 11.41 2206 875900 270398 62340518
Synovitis 368.60 11.41 4081 874025 182837 62428079
Nausea 357.08 11.41 9051 869055 845420 61765496
Device expulsion 356.25 11.41 35 878071 34887 62576029
Seizure 355.58 11.41 819 877287 131815 62479101
Dizziness 351.87 11.41 4027 874079 425898 62185018
Obstructive airways disorder 344.21 11.41 834 877272 19865 62591051
Intentional product use issue 326.96 11.41 2947 875159 124945 62485971
Malignant neoplasm progression 321.80 11.41 397 877709 81724 62529192
Vomiting 319.28 11.41 5634 872472 553983 62056933
Anaemia 316.39 11.41 2568 875538 290862 62320054
Musculoskeletal stiffness 312.25 11.41 3914 874192 180704 62430212
Somnolence 296.78 11.41 1365 876741 177320 62433596
Cardiac arrest 291.00 11.41 521 877585 92024 62518892
Infusion related reaction 289.88 11.41 4889 873217 240632 62370284
Abdominal discomfort 288.24 11.41 6126 871980 314759 62296157
Cardio-respiratory arrest 282.11 11.41 248 877858 59711 62551205
Alopecia 277.87 11.41 6364 871742 331172 62279744
Sleep disorder due to a general medical condition 264.35 11.41 546 877560 11642 62599274
Dehydration 263.73 11.41 1366 876740 171988 62438928
White blood cell count decreased 263.54 11.41 1010 877096 138094 62472822
Cognitive disorder 262.43 11.41 231 877875 55584 62555332
Hypoglycaemia 259.73 11.41 268 877838 59797 62551119
Sedation 254.10 11.41 109 877997 38700 62572216
Decreased appetite 251.71 11.41 2239 875867 248813 62362103
Wound 247.86 11.41 3394 874712 159869 62451047
Hypokalaemia 241.91 11.41 688 877418 103116 62507800
Nocardiosis 239.47 11.41 207 877899 1769 62609147
Intentional self-injury 239.22 11.41 35 878071 25652 62585264
Rhabdomyolysis 237.11 11.41 158 877948 43793 62567123
Loss of consciousness 228.70 11.41 850 877256 117271 62493645
Product use issue 219.97 11.41 4277 873829 216243 62394673
Peripheral swelling 219.23 11.41 5016 873090 260926 62349990
Serotonin syndrome 217.84 11.41 63 878043 28619 62582297
Orthostatic hypotension 217.64 11.41 114 877992 36046 62574870
Balance disorder 214.53 11.41 536 877570 83886 62527030
Tremor 213.13 11.41 1021 877085 131218 62479698
Epstein-Barr virus infection 210.28 11.41 390 877716 7660 62603256
Hepatic function abnormal 207.92 11.41 128 877978 37014 62573902
Anti-cyclic citrullinated peptide antibody positive 207.68 11.41 2490 875616 113722 62497194
Histoplasmosis disseminated 206.42 11.41 167 877939 1289 62609627
Lactic acidosis 204.71 11.41 139 877967 38148 62572768
Pericarditis 202.38 11.41 2742 875364 128837 62482079
Suicidal ideation 201.12 11.41 346 877760 62075 62548841
Weight increased 200.28 11.41 4871 873235 255921 62354995
Cytomegalovirus infection 198.49 11.41 690 877416 20262 62590654
Full blood count abnormal 195.01 11.41 913 877193 30804 62580112
Discomfort 194.83 11.41 3326 874780 164048 62446868
Neutrophil count decreased 191.66 11.41 302 877804 56104 62554812
Respiratory arrest 190.52 11.41 107 877999 32538 62578378
Hallucination 189.59 11.41 290 877816 54527 62556389
Hyperkalaemia 189.16 11.41 285 877821 53918 62556998
Drug withdrawal syndrome 188.47 11.41 70 878036 27124 62583792
Agitation 186.41 11.41 338 877768 59419 62551497
Metabolic acidosis 186.05 11.41 209 877897 44860 62566056
Inflammation 183.89 11.41 1843 876263 80430 62530486
Blood pressure fluctuation 180.97 11.41 1179 876927 45138 62565778
Pneumocystis jirovecii pneumonia 178.82 11.41 578 877528 16336 62594580
Strongyloidiasis 178.75 11.41 144 877962 1104 62609812
Osteoporosis 178.27 11.41 1381 876725 55957 62554959
Product use in unapproved indication 177.39 11.41 3470 874636 175610 62435306
Diarrhoea 172.93 11.41 8112 869994 707254 61903662
Wrong technique in product usage process 172.65 11.41 378 877728 61962 62548954
Lower respiratory tract infection 171.73 11.41 2677 875429 129630 62481286
Multiple sclerosis relapse 170.04 11.41 254 877852 48224 62562692
Syncope 169.56 11.41 941 877165 116444 62494472
Aspergillus infection 169.03 11.41 357 877749 7736 62603180
Productive cough 168.88 11.41 1471 876635 61737 62549179
Intentional product misuse 168.18 11.41 370 877736 60547 62550369
Sputum discoloured 166.87 11.41 552 877554 15795 62595121
Sinusitis 164.62 11.41 4202 873904 222451 62388465
Forced expiratory volume decreased 164.14 11.41 267 877839 4701 62606215
Transplant rejection 162.05 11.41 418 877688 10362 62600554
Infection 157.53 11.41 4218 873888 224955 62385961
Red blood cell sedimentation rate increased 157.12 11.41 1095 877011 42887 62568029
Palmar-plantar erythrodysaesthesia syndrome 156.57 11.41 61 878045 22954 62587962
Arthritis 156.01 11.41 2360 875746 113561 62497355
Dyskinesia 155.87 11.41 128 877978 31874 62579042
Lethargy 154.76 11.41 340 877766 55667 62555249
Hypersensitivity 154.29 11.41 5213 872893 287472 62323444
Blood calcium decreased 153.93 11.41 87 878019 26364 62584552
Platelet count decreased 153.83 11.41 957 877149 115165 62495751
Neutropenia 151.96 11.41 1616 876490 173389 62437527
Cushingoid 150.94 11.41 351 877755 8134 62602782
Gastrointestinal haemorrhage 150.73 11.41 594 877512 80582 62530334
Unresponsive to stimuli 150.62 11.41 147 877959 33669 62577247
Cerebrovascular accident 150.59 11.41 876 877230 107148 62503768
Creatinine renal clearance decreased 147.80 11.41 24 878082 16284 62594632
International normalised ratio increased 146.22 11.41 261 877845 46164 62564752
Ill-defined disorder 145.26 11.41 1750 876356 80005 62530911
Blood pressure systolic increased 144.81 11.41 1137 876969 46260 62564656
Smooth muscle cell neoplasm 144.30 11.41 108 877998 733 62610183
Trichodysplasia spinulosa 143.36 11.41 93 878013 484 62610432
Kidney transplant rejection 143.10 11.41 231 877875 4040 62606876
Product dose omission issue 142.80 11.41 2329 875777 231984 62378932
Polyomavirus-associated nephropathy 142.79 11.41 151 877955 1697 62609219
Sopor 139.22 11.41 66 878040 22098 62588818
Disease recurrence 137.33 11.41 757 877349 27273 62583643
Neuropathy peripheral 135.87 11.41 966 877140 112701 62498215
Tachycardia 135.53 11.41 1016 877090 117140 62493776
Hyperhidrosis 133.54 11.41 907 877199 106929 62503987
C-reactive protein abnormal 132.77 11.41 1091 877015 45005 62565911
Faecal calprotectin increased 132.42 11.41 191 877915 3012 62607904
Nasopharyngitis 131.78 11.41 4520 873586 249737 62361179
Poisoning 131.51 11.41 17 878089 13683 62597233
Cytomegalovirus viraemia 129.55 11.41 259 877847 5390 62605526
Histoplasmosis 127.96 11.41 147 877959 1824 62609092
Disturbance in attention 127.34 11.41 207 877899 37982 62572934
Product quality issue 126.67 11.41 187 877919 35678 62575238
Depression 124.06 11.41 1940 876166 194552 62416364
Cardiac failure congestive 123.85 11.41 759 877347 91674 62519242
Hepatic enzyme increased 123.67 11.41 3669 874437 198659 62412257
Product substitution issue 123.58 11.41 34 878072 15962 62594954
Metastases to liver 123.48 11.41 88 878018 23551 62587365
Muscle spasms 122.91 11.41 1474 876632 154676 62456240
Aggression 122.06 11.41 88 878018 23410 62587506
Device dislocation 121.28 11.41 106 878000 25599 62585317
Metastases to bone 121.07 11.41 70 878036 20949 62589967
Neuroleptic malignant syndrome 120.59 11.41 13 878093 12043 62598873
Dysarthria 119.90 11.41 257 877849 42454 62568462
Circulatory collapse 118.14 11.41 79 878027 21859 62589057
Dysgeusia 117.53 11.41 298 877808 46412 62564504
Maternal exposure during pregnancy 117.52 11.41 3926 874180 216136 62394780
Hypomagnesaemia 116.72 11.41 135 877971 28602 62582314
Red blood cell sedimentation rate abnormal 116.19 11.41 562 877544 19220 62591696
Altered state of consciousness 115.50 11.41 107 877999 25123 62585793
Palpitations 115.39 11.41 1000 877106 111770 62499146
Renal failure 113.09 11.41 1060 877046 116592 62494324
Coma 112.59 11.41 482 877624 63882 62547034
Muscle injury 112.28 11.41 1390 876716 63955 62546961
Gastrointestinal disorder 112.22 11.41 2489 875617 128750 62482166
Cardiac failure 111.25 11.41 748 877358 88394 62522522
Haematemesis 109.93 11.41 156 877950 30256 62580660
Rheumatoid factor positive 108.39 11.41 1705 876401 82701 62528215
Melaena 107.55 11.41 158 877948 30207 62580709
Poisoning deliberate 107.49 11.41 14 878092 11204 62599712
Rebound effect 106.79 11.41 210 877896 4316 62606600
Nasal polyps 106.53 11.41 249 877857 5790 62605126
Frequent bowel movements 106.33 11.41 612 877494 22410 62588506
Impaired healing 105.55 11.41 1999 876107 100543 62510373
Varicella zoster virus infection 104.87 11.41 156 877950 2533 62608383
Cryptococcosis 104.79 11.41 103 878003 1054 62609862
Transient ischaemic attack 104.45 11.41 229 877877 37524 62573392
Folliculitis 104.22 11.41 1456 876650 68861 62542055
Cough 103.75 11.41 4997 873109 287746 62323170
Brain abscess 103.64 11.41 137 877969 1981 62608935
Anxiety 102.64 11.41 2259 875847 215282 62395634
Blood alkaline phosphatase increased 102.12 11.41 282 877824 42685 62568231
Phaeohyphomycosis 100.51 11.41 59 878047 248 62610668
Psoriatic arthropathy 99.71 11.41 1800 876306 89720 62521196
Device difficult to use 99.23 11.41 27 878079 12769 62598147
Accidental exposure to product 98.64 11.41 141 877965 27264 62583652
Atrial fibrillation 97.60 11.41 1086 877020 115550 62495366
Memory impairment 97.35 11.41 946 877160 103312 62507604
Oedema peripheral 97.30 11.41 1941 876165 187570 62423346
Haemophagocytic lymphohistiocytosis 97.23 11.41 346 877760 10281 62600635
Confusional state 97.06 11.41 2507 875599 233873 62377043
Rheumatoid nodule 96.92 11.41 482 877624 16673 62594243
Mucous stools 96.50 11.41 194 877912 4054 62606862
Epistaxis 95.95 11.41 600 877506 72125 62538791
Respiratory depression 95.55 11.41 35 878071 13680 62597236
Helicobacter infection 94.87 11.41 1807 876299 90978 62519938
Duodenal ulcer perforation 93.88 11.41 1712 876394 85497 62525419
Paraesthesia 93.65 11.41 1566 876540 155400 62455516
Amnesia 92.54 11.41 424 877682 55161 62555755
Drug level below therapeutic 91.77 11.41 206 877900 4660 62606256
Sensitivity to weather change 91.18 11.41 263 877843 6974 62603942
Diffuse large B-cell lymphoma recurrent 91.06 11.41 135 877971 2185 62608731
Ascites 90.45 11.41 276 877830 40452 62570464
Cerebral haemorrhage 88.69 11.41 182 877924 30547 62580369
Dystonia 88.58 11.41 40 878066 13779 62597137
Epidermodysplasia verruciformis 88.40 11.41 41 878065 91 62610825
Mobility decreased 88.07 11.41 2247 875859 118912 62492004
Blood creatine phosphokinase increased 88.02 11.41 180 877926 30250 62580666
Urinary retention 87.85 11.41 179 877927 30122 62580794
Thrombocytopenia 87.59 11.41 1516 876590 149641 62461275
Respiratory disorder 87.54 11.41 876 877230 38206 62572710
Hepatitis B reactivation 87.03 11.41 156 877950 2981 62607935
Irritable bowel syndrome 86.67 11.41 1612 876494 80800 62530116
Gamma-glutamyltransferase increased 86.47 11.41 216 877890 33815 62577101
Epilepsy 86.27 11.41 151 877955 26914 62584002
Arrhythmia 85.74 11.41 257 877849 37883 62573033
Labelled drug-drug interaction medication error 85.55 11.41 39 878067 13360 62597556
Tardive dyskinesia 85.47 11.41 9 878097 8493 62602423
Therapeutic response shortened 85.00 11.41 358 877748 11530 62599386
Eosinophilic bronchitis 83.95 11.41 67 878039 506 62610410
Blood glucose increased 83.77 11.41 747 877359 83009 62527907
Myocardial infarction 83.61 11.41 930 877176 98963 62511953
Torsade de pointes 83.48 11.41 40 878066 13311 62597605
Vaginal haemorrhage 83.47 11.41 158 877948 27329 62583587
Blood pressure diastolic abnormal 82.45 11.41 409 877697 14133 62596783
Muscle rigidity 82.43 11.41 28 878078 11472 62599444
Steroid diabetes 82.31 11.41 96 878010 1212 62609704
Therapeutic reaction time decreased 81.89 11.41 130 877976 2240 62608676
Withdrawal syndrome 81.15 11.41 94 878012 19903 62591013
Metastases to central nervous system 80.82 11.41 40 878066 13065 62597851
Alanine aminotransferase increased 80.69 11.41 982 877124 102788 62508128
Limb deformity 80.65 11.41 174 877932 3828 62607088
Product administration error 79.85 11.41 116 877990 22281 62588635
Disorientation 79.55 11.41 279 877827 39173 62571743
Full blood count decreased 79.55 11.41 149 877957 25875 62585041
Akathisia 79.52 11.41 15 878091 9131 62601785
Hallucination, auditory 79.31 11.41 39 878067 12785 62598131
Aspartate aminotransferase increased 78.55 11.41 833 877273 89444 62521472
Skin ulcer 78.45 11.41 926 877180 42119 62568797
Hallucination, visual 78.01 11.41 91 878015 19207 62591709
Respiratory tract congestion 77.81 11.41 467 877639 17365 62593551
Mycobacterial infection 77.66 11.41 109 877997 1674 62609242
Suspected suicide 77.61 11.41 3 878103 6565 62604351
Sensitisation 77.35 11.41 155 877951 3231 62607685
Plasma cell myeloma 77.13 11.41 247 877859 35658 62575258
Steroid dependence 77.07 11.41 108 877998 1656 62609260
Adrenal insufficiency 76.79 11.41 467 877639 17448 62593468
Subdural haematoma 76.61 11.41 52 878054 14276 62596640
Product prescribing error 76.47 11.41 155 877951 26134 62584782
Cytomegalovirus colitis 76.36 11.41 126 877980 2246 62608670
Polyarthritis 76.05 11.41 310 877796 9836 62601080
Mydriasis 76.02 11.41 35 878071 11921 62598995
Ventricular tachycardia 75.72 11.41 99 878007 19880 62591036
Generalised tonic-clonic seizure 75.43 11.41 182 877924 28834 62582082
Vision blurred 75.28 11.41 860 877246 91064 62519852
Foetal exposure during pregnancy 75.04 11.41 211 877895 31751 62579165
Renal impairment 74.97 11.41 820 877286 87535 62523381
Neutropenic sepsis 74.91 11.41 70 878036 16368 62594548
Diabetic ketoacidosis 74.29 11.41 105 878001 20400 62590516
Flushing 73.64 11.41 673 877433 74414 62536502
Drug reaction with eosinophilia and systemic symptoms 72.52 11.41 233 877873 33603 62577313
Haematoma 72.40 11.41 243 877863 34577 62576339
Sinus bradycardia 72.36 11.41 57 878049 14494 62596422
Diffuse large B-cell lymphoma 71.52 11.41 230 877876 6482 62604434
Cerebral infarction 71.11 11.41 139 877967 23754 62587162
Stevens-Johnson syndrome 70.97 11.41 149 877957 24801 62586115
Accidental overdose 70.76 11.41 134 877972 23175 62587741
Therapy partial responder 70.11 11.41 313 877793 10345 62600571
Deformity 70.11 11.41 334 877772 11350 62599566
Bronchiectasis 69.96 11.41 422 877684 15720 62595196
Restlessness 69.47 11.41 194 877912 29259 62581657
Dementia 69.33 11.41 95 878011 18699 62592217
Blood immunoglobulin E increased 69.32 11.41 160 877946 3689 62607227
Delusion 69.24 11.41 40 878066 11977 62598939
Medication error 69.15 11.41 431 877675 51853 62559063
Meningitis cryptococcal 68.82 11.41 90 878016 1287 62609629
Vaccination failure 68.28 11.41 68 878038 708 62610208
Neoplasm progression 67.96 11.41 266 877840 36162 62574754
Haematochezia 67.74 11.41 1079 877027 52465 62558451
West Nile viral infection 67.70 11.41 51 878055 350 62610566
Blood bilirubin increased 67.51 11.41 274 877832 36866 62574050
Renal transplant failure 67.46 11.41 67 878039 695 62610221
Parkinsonism 67.25 11.41 30 878076 10409 62600507
Blood pressure systolic abnormal 67.24 11.41 364 877742 13022 62597894
Dry skin 67.20 11.41 485 877621 56402 62554514
Complication of device insertion 66.64 11.41 12 878094 7552 62603364
Contrast media allergy 66.10 11.41 119 877987 2282 62608634
Blood pressure diastolic decreased 65.69 11.41 538 877568 22168 62588748
Hypothermia 65.29 11.41 55 878051 13526 62597390
Breast cancer stage I 65.05 11.41 9 878097 6880 62604036
Abnormal dreams 65.00 11.41 32 878074 10484 62600432
Impaired quality of life 64.70 11.41 368 877738 13415 62597501
Epidural lipomatosis 64.61 11.41 32 878074 87 62610829
Sleep disorder due to general medical condition, insomnia type 64.47 11.41 1048 877058 51169 62559747
Hypophagia 64.41 11.41 219 877887 31040 62579876
Obliterative bronchiolitis 64.39 11.41 109 877997 1986 62608930
Fluid retention 63.85 11.41 523 877583 59163 62551753
Panniculitis 63.69 11.41 319 877787 11066 62599850
Acute myocardial infarction 63.55 11.41 229 877877 31895 62579021
Ventricular fibrillation 63.54 11.41 43 878063 11824 62599092
Blister 63.48 11.41 2293 875813 127521 62483395
Immunosuppressant drug level increased 63.08 11.41 149 877957 3489 62607427
Heart rate increased 63.07 11.41 1729 876377 92509 62518407
Temperature regulation disorder 62.92 11.41 6 878100 6126 62604790
Knee arthroplasty 62.55 11.41 1076 877030 53130 62557786
Infection reactivation 62.48 11.41 80 878026 1119 62609797
Therapeutic response decreased 62.46 11.41 1197 876909 60328 62550588
C-reactive protein increased 62.36 11.41 1734 876372 92973 62517943
Body temperature increased 62.10 11.41 787 877319 36405 62574511
Complications of transplanted kidney 61.89 11.41 118 877988 2368 62608548
Breast cancer 61.85 11.41 403 877703 47980 62562936
Complication associated with device 61.45 11.41 87 878019 16891 62594025
Drug specific antibody 61.39 11.41 114 877992 2241 62608675
Inappropriate antidiuretic hormone secretion 61.33 11.41 74 878032 15388 62595528
BK virus infection 60.93 11.41 138 877968 3141 62607775
Jaundice 60.91 11.41 204 877902 29047 62581869
Dust allergy 60.67 11.41 61 878045 643 62610273
Hepatic failure 60.53 11.41 270 877836 35386 62575530
Anal fissure 60.42 11.41 166 877940 4277 62606639
Coronary artery disease 60.03 11.41 237 877869 32140 62578776
Extrapyramidal disorder 60.03 11.41 57 878049 13227 62597689
Breast cancer metastatic 59.86 11.41 47 878059 11971 62598945
Disseminated cryptococcosis 59.79 11.41 49 878057 386 62610530
Liver function test abnormal 59.74 11.41 405 877701 47776 62563140
Pallor 59.09 11.41 220 877886 30348 62580568
Mental status changes 59.04 11.41 314 877792 39285 62571631
Chest pain 59.02 11.41 2414 875692 213545 62397371
Incorrect product administration duration 58.98 11.41 44 878062 11502 62599414
Breath sounds abnormal 58.97 11.41 304 877802 10669 62600247
Rash 58.65 11.41 8726 869380 552145 62058771
Exposure to toxic agent 58.59 11.41 5 878101 5582 62605334
Mycobacterium avium complex infection 58.54 11.41 131 877975 2957 62607959
Myalgia 58.52 11.41 1560 876546 144969 62465947
Abnormal behaviour 58.42 11.41 131 877975 21295 62589621
Blood urea increased 58.40 11.41 179 877927 26200 62584716
Joint injury 58.31 11.41 646 877460 28926 62581990
Ear pain 58.08 11.41 759 877347 35359 62575557
Hip arthroplasty 57.98 11.41 954 877152 46692 62564224
Hypocalcaemia 57.62 11.41 234 877872 31479 62579437
Restless legs syndrome 57.61 11.41 105 878001 18426 62592490
Angioedema 57.59 11.41 407 877699 47558 62563358
Chronic allograft nephropathy 57.16 11.41 60 878046 668 62610248
Septic shock 57.02 11.41 1264 876842 65365 62545551
Polymyalgia rheumatica 56.98 11.41 147 877959 3644 62607272
Humoral immune defect 56.89 11.41 39 878067 226 62610690
Osteoporotic fracture 56.04 11.41 145 877961 3601 62607315
Rhinitis allergic 55.64 11.41 314 877792 11413 62599503
Poor venous access 55.10 11.41 372 877734 14413 62596503
Device issue 55.08 11.41 158 877948 23623 62587293
Urinary incontinence 54.60 11.41 242 877864 31772 62579144
Salivary hypersecretion 54.37 11.41 19 878087 7647 62603269
Herpes zoster 54.34 11.41 1510 876596 80952 62529964
Nightmare 54.28 11.41 115 877991 19079 62591837
Metastases to lung 53.86 11.41 58 878048 12692 62598224
Myoclonus 53.85 11.41 85 878021 15783 62595133
Sarcoidosis 53.69 11.41 218 877888 6904 62604012
Breast cancer female 53.67 11.41 65 878041 13494 62597422
Cytomegalovirus gastrointestinal infection 53.62 11.41 40 878066 270 62610646
Eosinophil count increased 53.44 11.41 295 877811 10633 62600283
Atrioventricular block first degree 53.37 11.41 17 878089 7256 62603660
Lupus nephritis 53.33 11.41 120 877986 2719 62608197
Joint stiffness 53.06 11.41 844 877262 41025 62569891
Treatment noncompliance 52.89 11.41 301 877805 37024 62573892
Device adhesion issue 52.83 11.41 5 878101 5136 62605780
Central nervous system lymphoma 52.74 11.41 83 878023 1419 62609497
Biopsy lung abnormal 52.69 11.41 31 878075 131 62610785
Delirium 52.64 11.41 446 877660 50095 62560821
Blood creatinine increased 52.48 11.41 876 877230 86968 62523948
Epstein-Barr virus associated lymphoproliferative disorder 52.30 11.41 94 878012 1800 62609116
Foot deformity 52 11.41 602 877504 27251 62583665
Depressed mood 51.76 11.41 334 877772 39857 62571059
Dysphagia 51.75 11.41 887 877219 87698 62523218
Impaired work ability 51.61 11.41 416 877690 17059 62593857
Uterine perforation 51.59 11.41 16 878090 6947 62603969
Bronchial wall thickening 51.49 11.41 82 878024 1417 62609499
Haemoglobin decreased 51.47 11.41 1575 876531 143910 62467006
Substance abuse 51.24 11.41 4 878102 4803 62606113
Defaecation urgency 50.94 11.41 150 877956 4025 62606891
Joint effusion 50.86 11.41 407 877699 16653 62594263
Miosis 50.83 11.41 19 878087 7334 62603582
Mental impairment 50.73 11.41 73 878033 14078 62596838
Toxic epidermal necrolysis 50.51 11.41 180 877926 25154 62585762
Granuloma skin 50.49 11.41 241 877865 8196 62602720
Skin exfoliation 50.17 11.41 369 877737 42733 62568183
Blood pressure diastolic increased 50.14 11.41 272 877834 9738 62601178
Aphasia 50.13 11.41 260 877846 32740 62578176
Unintended pregnancy 49.91 11.41 12 878094 6167 62604749
Bone pain 49.64 11.41 499 877607 54142 62556774
Bacillary angiomatosis 49.55 11.41 26 878080 83 62610833
Candida infection 49.51 11.41 605 877501 27746 62583170
Multiple sclerosis 49.37 11.41 172 877934 24200 62586716
Vasculitis 49.25 11.41 425 877681 17784 62593132
Upper gastrointestinal haemorrhage 49.20 11.41 118 877988 18734 62592182
Unintentional medical device removal 49.15 11.41 12 878094 6103 62604813
Genital haemorrhage 48.94 11.41 20 878086 7312 62603604
Device use error 48.93 11.41 10 878096 5751 62605165
Colectomy 48.78 11.41 110 877996 2496 62608420
Body height below normal 48.76 11.41 99 878007 2084 62608832
Musculoskeletal pain 48.59 11.41 1644 876462 90633 62520283
Ketoacidosis 48.54 11.41 3 878103 4375 62606541
Blood parathyroid hormone decreased 48.34 11.41 265 877841 9526 62601390
Osteonecrosis of jaw 48.29 11.41 286 877820 34837 62576079
Sexual dysfunction 48.29 11.41 3 878103 4356 62606560
Complication of device removal 47.89 11.41 7 878099 5135 62605781
Delayed graft function 47.87 11.41 67 878039 1026 62609890
Sickle cell anaemia with crisis 47.82 11.41 12 878094 5991 62604925
Cataract 47.77 11.41 1079 877027 55974 62554942
Pleural effusion 47.69 11.41 955 877151 92255 62518661
Uveitis 47.48 11.41 317 877789 12236 62598680
Product adhesion issue 47.42 11.41 5 878101 4714 62606202
Human antichimeric antibody positive 47.25 11.41 85 878021 1629 62609287
Liver transplant rejection 47.24 11.41 77 878029 1358 62609558
Tenosynovitis 47.24 11.41 340 877766 13455 62597461
Blood sodium decreased 47.24 11.41 174 877932 24078 62586838
Human polyomavirus infection 47.10 11.41 38 878068 292 62610624
Gastritis 47.03 11.41 312 877794 36991 62573925
Diabetes mellitus 46.89 11.41 1056 877050 54754 62556162
Feeling abnormal 46.67 11.41 1631 876475 146761 62464155
Coccidioidomycosis 46.62 11.41 62 878044 902 62610014
Hot flush 46.56 11.41 467 877639 50692 62560224
Bone density decreased 46.55 11.41 354 877752 14258 62596658
Posterior reversible encephalopathy syndrome 46.48 11.41 404 877702 16941 62593975
Ulcer 46.41 11.41 559 877547 25548 62585368
Acquired haemophilia 46.35 11.41 64 878042 967 62609949
Polyp 46.33 11.41 196 877910 6325 62604591
Lymphocyte count decreased 46.18 11.41 238 877868 30019 62580897
Renal graft infection 45.75 11.41 34 878072 228 62610688
Pre-existing disease 45.68 11.41 30 878076 160 62610756
Hypogammaglobulinaemia 45.47 11.41 208 877898 6947 62603969
Secondary immunodeficiency 45.25 11.41 74 878032 1309 62609607
Blood pressure decreased 45.13 11.41 630 877476 64392 62546524
Tumour marker increased 45.07 11.41 7 878099 4908 62606008
Crohn's disease 44.98 11.41 160 877946 4753 62606163
Disability 44.90 11.41 419 877687 17928 62592988
Pulmonary embolism 44.83 11.41 1249 876857 115435 62495481
Inappropriate schedule of product administration 44.53 11.41 1810 876296 102155 62508761
Wrist deformity 44.53 11.41 94 878012 2036 62608880
Asthenia 44.41 11.41 4636 873470 378968 62231948
Epstein-Barr viraemia 44.37 11.41 62 878044 948 62609968
Pruritus allergic 44.31 11.41 79 878027 1503 62609413
Eye infection toxoplasmal 44.30 11.41 35 878071 260 62610656
Caesarean section 44.14 11.41 107 877999 16925 62593991
Therapy non-responder 44.04 11.41 1368 876738 74533 62536383
Device breakage 43.94 11.41 57 878049 11485 62599431
Multiple-drug resistance 43.86 11.41 9 878097 5161 62605755
Drug level decreased 43.68 11.41 221 877885 7698 62603218
Heart transplant rejection 43.57 11.41 48 878058 567 62610349
Bronchopulmonary aspergillosis 43.50 11.41 235 877871 8400 62602516
Psychotic disorder 43.47 11.41 195 877911 25517 62585399
Swollen tongue 43.40 11.41 292 877814 34508 62576408
Listeriosis 42.66 11.41 76 878030 1445 62609471
Animal scratch 42.56 11.41 73 878033 1345 62609571
Vertigo 42.37 11.41 578 877528 59309 62551607
Aphthous ulcer 42.36 11.41 334 877772 13604 62597312
Pulmonary fibrosis 42.30 11.41 780 877326 39029 62571887
Hyperprolactinaemia 42.27 11.41 3 878103 3897 62607019
Ataxia 42.17 11.41 92 878014 15103 62595813
Personality change 41.93 11.41 22 878084 6951 62603965
Hypertonia 41.63 11.41 7 878099 4630 62606286
Granuloma 41.59 11.41 174 877932 5587 62605329
Ear pruritus 41.46 11.41 135 877971 3830 62607086
Acanthamoeba infection 41.32 11.41 19 878087 41 62610875
Herpes simplex hepatitis 41.23 11.41 39 878067 379 62610537
Heavy menstrual bleeding 41.23 11.41 118 877988 17655 62593261
Nasal congestion 41.22 11.41 1195 876911 64465 62546451
Systemic lupus erythematosus rash 40.98 11.41 94 878012 2158 62608758
Drug tolerance decreased 40.75 11.41 395 877711 17078 62593838
Cholecystitis chronic 40.66 11.41 50 878056 10311 62600605
Bradyphrenia 40.55 11.41 23 878083 6957 62603959
American trypanosomiasis 40.48 11.41 21 878085 65 62610851
Galactorrhoea 40.26 11.41 5 878101 4150 62606766
Chronic kidney disease 40.25 11.41 417 877689 44981 62565935
Schizophrenia 40.15 11.41 47 878059 9905 62601011
Nasal oedema 40.08 11.41 74 878032 1448 62609468
Toxic skin eruption 40.06 11.41 73 878033 12812 62598104
Sinus tachycardia 39.86 11.41 186 877920 24082 62586834
Mycobacterium chelonae infection 39.85 11.41 42 878064 470 62610446
Application site erythema 39.82 11.41 9 878097 4826 62606090
Ejection fraction decreased 39.81 11.41 166 877940 22166 62588750
Therapy cessation 39.79 11.41 252 877854 30205 62580711
Arthritis bacterial 39.69 11.41 186 877920 6277 62604639
Cyanosis 39.60 11.41 112 877994 16823 62594093
Clonus 39.47 11.41 8 878098 4628 62606288
Sensory disturbance 39.43 11.41 81 878025 13591 62597325
Euglycaemic diabetic ketoacidosis 39.33 11.41 3 878103 3671 62607245
Lupus-like syndrome 39.31 11.41 353 877753 14942 62595974
Abortion spontaneous 39.23 11.41 440 877666 46755 62564161
Finger deformity 39.17 11.41 211 877895 7534 62603382
Pseudohyponatraemia 39.14 11.41 17 878089 30 62610886
Multiple drug therapy 38.96 11.41 3 878103 3643 62607273
No adverse event 38.92 11.41 375 877731 41030 62569886
Oropharyngeal pain 38.87 11.41 1638 876468 92849 62518067
Wrist surgery 38.87 11.41 54 878052 821 62610095
Swollen joint count increased 38.85 11.41 708 877398 35346 62575570
Toxoplasmosis 38.80 11.41 73 878033 1450 62609466
Subarachnoid haemorrhage 38.39 11.41 88 878018 14195 62596721
Electrocardiogram QRS complex prolonged 38.35 11.41 17 878089 5921 62604995
Drug effective for unapproved indication 38.35 11.41 118 877988 3246 62607670
Blood test abnormal 38.28 11.41 357 877749 15272 62595644
Clostridium difficile infection 38.23 11.41 604 877502 29318 62581598
Musculoskeletal disorder 38.01 11.41 445 877661 20199 62590717
Ejection fraction 37.94 11.41 95 878011 2311 62608605
Lung transplant rejection 37.92 11.41 55 878051 872 62610044
Urticaria 37.91 11.41 2722 875384 163080 62447836
SARS-CoV-2 RNA increased 37.86 11.41 20 878086 65 62610851
Bloody discharge 37.85 11.41 73 878033 1478 62609438
Visual acuity reduced 37.82 11.41 164 877942 21662 62589254
Hypoxia 37.79 11.41 590 877516 59202 62551714
Neuroendocrine carcinoma of the skin 37.70 11.41 44 878062 556 62610360
Lung disorder 37.68 11.41 1128 876978 61133 62549783
Status epilepticus 37.68 11.41 98 878008 15135 62595781
Hypernatraemia 37.59 11.41 30 878076 7579 62603337
Ischaemic stroke 37.55 11.41 125 877981 17832 62593084
Irritability 37.53 11.41 270 877836 31424 62579492
Human herpesvirus 8 infection 37.44 11.41 30 878076 228 62610688
Rheumatic fever 37.24 11.41 819 877287 42292 62568624
Anaphylactic shock 37.15 11.41 184 877922 23449 62587467
Urinary tract infection 37.12 11.41 3153 874953 261531 62349385
Fear 37.07 11.41 104 878002 15662 62595254
Vital capacity decreased 36.99 11.41 77 878029 1651 62609265
Bronchial disorder 36.88 11.41 65 878041 1225 62609691
Hepatic cytolysis 36.69 11.41 101 878005 15306 62595610
Upper-airway cough syndrome 36.58 11.41 277 877829 11141 62599775
Visceral leishmaniasis 36.57 11.41 42 878064 521 62610395
Pulmonary nocardiosis 36.54 11.41 34 878072 323 62610593
Ventricular extrasystoles 36.53 11.41 66 878040 11621 62599295
Muscle twitching 36.44 11.41 144 877962 19524 62591392
Antipsychotic drug level increased 36.22 11.41 3 878103 3432 62607484
Acute generalised exanthematous pustulosis 36.22 11.41 61 878045 11038 62599878
Pregnancy with contraceptive device 36.22 11.41 10 878096 4684 62606232
Angina pectoris 36.21 11.41 255 877851 29823 62581093
Calciphylaxis 36.18 11.41 109 877997 2963 62607953
Eosinophilic granulomatosis with polyangiitis 36.09 11.41 88 878018 2104 62608812
Necrotising retinitis 36.06 11.41 36 878070 376 62610540
Alternaria infection 36.03 11.41 29 878077 222 62610694
Mucocutaneous leishmaniasis 36.00 11.41 35 878071 353 62610563
Lennox-Gastaut syndrome 35.57 11.41 30 878076 247 62610669
Blastomycosis 35.47 11.41 32 878074 291 62610625
Ileostomy 35.25 11.41 69 878037 1413 62609503
Schizoaffective disorder 35.22 11.41 4 878102 3558 62607358
Polyomavirus viraemia 35.18 11.41 47 878059 687 62610229
Pulmonary function test abnormal 35.10 11.41 78 878028 1752 62609164
Thirst 34.99 11.41 90 878016 13951 62596965
Visual impairment 34.76 11.41 895 877211 83551 62527365
Blood pressure increased 34.75 11.41 2647 875459 159415 62451501
Intermenstrual bleeding 34.67 11.41 35 878071 7891 62603025
Wheelchair user 34.61 11.41 176 877930 6143 62604773
Dry mouth 34.56 11.41 816 877290 77047 62533869
Scleritis 34.55 11.41 137 877969 4291 62606625
Dermatomyositis 34.44 11.41 102 878004 2746 62608170
Mycotic allergy 34.35 11.41 55 878051 955 62609961
Escherichia bacteraemia 34.31 11.41 125 877981 3758 62607158
Device occlusion 34.20 11.41 31 878075 7356 62603560
Respiratory symptom 34.14 11.41 113 877993 3234 62607682
Myopathy 33.91 11.41 268 877838 10923 62599993
Secretion discharge 33.88 11.41 287 877819 11944 62598972
Sinus pain 33.78 11.41 114 877992 3296 62607620
Coordination abnormal 33.77 11.41 89 878017 13684 62597232
Rhinorrhoea 33.68 11.41 1165 876941 64412 62546504
Prothrombin time prolonged 33.64 11.41 50 878056 9514 62601402
Device malfunction 33.56 11.41 130 877976 17727 62593189
Parvovirus B19 infection 33.53 11.41 40 878066 518 62610398
Sporotrichosis 33.50 11.41 16 878090 39 62610877
Mood altered 33.38 11.41 99 878007 14644 62596272
Apnoea 33.32 11.41 37 878069 7985 62602931
Bone swelling 33.28 11.41 73 878033 1625 62609291
Loose body in joint 33.21 11.41 62 878044 1224 62609692
Total lung capacity increased 33.11 11.41 88 878018 2222 62608694
Right ventricular failure 33.03 11.41 124 877982 17064 62593852
Pulmonary toxicity 32.94 11.41 234 877872 9221 62601695
Encephalopathy 32.92 11.41 358 877748 38262 62572654
Coma scale abnormal 32.90 11.41 15 878091 5138 62605778
Peak expiratory flow rate decreased 32.83 11.41 42 878064 587 62610329
Product preparation error 32.72 11.41 22 878084 6070 62604846
Faecaloma 32.58 11.41 37 878069 7904 62603012
Speech disorder 32.51 11.41 382 877724 40247 62570669
Laboratory test abnormal 32.48 11.41 228 877878 26684 62584232
Herpes simplex oesophagitis 32.28 11.41 24 878082 161 62610755
Hypotonia 32.21 11.41 49 878057 9236 62601680
Immobile 32.18 11.41 165 877941 5778 62605138
Mental disorder 32.06 11.41 218 877888 25701 62585215
Ovarian hyperstimulation syndrome 32.02 11.41 8 878098 4006 62606910
Therapy responder 31.94 11.41 31 878075 312 62610604
Drug specific antibody present 31.82 11.41 130 877976 4129 62606787
Presyncope 31.79 11.41 239 877867 27546 62583370
Electrolyte imbalance 31.73 11.41 156 877950 19920 62590996
Arthrodesis 31.70 11.41 98 878008 2703 62608213
Disseminated mycobacterium avium complex infection 31.69 11.41 21 878085 114 62610802
Rheumatoid lung 31.61 11.41 121 877985 3727 62607189
Human ehrlichiosis 31.56 11.41 23 878083 149 62610767
Femoral neck fracture 31.52 11.41 43 878063 8480 62602436
Drug screen positive 31.45 11.41 6 878100 3623 62607293
JC virus infection 31.31 11.41 80 878026 1971 62608945
Diplopia 31.16 11.41 196 877910 23532 62587384
Multifocal micronodular pneumocyte hyperplasia 31.15 11.41 18 878088 73 62610843
Bronchial polyp 31.15 11.41 18 878088 73 62610843
Pain in extremity 31.04 11.41 5127 872979 326359 62284557
Pre-engraftment immune reaction 31.03 11.41 26 878080 212 62610704
Tuberculin test positive 31.00 11.41 113 877993 3398 62607518
Cholestasis 30.98 11.41 259 877847 29175 62581741
Sudden death 30.91 11.41 61 878045 10388 62600528
Psychomotor hyperactivity 30.90 11.41 63 878043 10600 62600316
Nephrectomy 30.89 11.41 66 878040 1442 62609474
Hypertensive crisis 30.88 11.41 108 877998 15178 62595738
Myocardial ischaemia 30.85 11.41 84 878022 12775 62598141
Pneumonia aspiration 30.73 11.41 317 877789 34223 62576693
Episcleritis 30.70 11.41 52 878054 948 62609968
Type 2 diabetes mellitus 30.67 11.41 1126 876980 62742 62548174
Left ventricular dysfunction 30.52 11.41 76 878030 11912 62599004
Skin necrosis 30.42 11.41 311 877795 13639 62597277
Psychomotor retardation 30.32 11.41 8 878098 3862 62607054
Device leakage 30.28 11.41 32 878074 7064 62603852
Rash erythematous 30.17 11.41 410 877696 42100 62568816
Atrioventricular block complete 30.14 11.41 42 878064 8209 62602707
Pulmonary hypertension 30.11 11.41 348 877758 36775 62574141
Sputum purulent 30.08 11.41 54 878052 1033 62609883
Cerebral aspergillosis 30.01 11.41 33 878073 389 62610527
Polycystic ovaries 29.94 11.41 132 877974 4339 62606577
Nodule 29.79 11.41 432 877674 20594 62590322
Abortion incomplete 29.78 11.41 4 878102 3127 62607789
Product complaint 29.74 11.41 85 878021 12724 62598192
Urinary tract discomfort 29.72 11.41 41 878065 619 62610297
Deep vein thrombosis 29.67 11.41 907 877199 82893 62528023
Erythema multiforme 29.54 11.41 60 878046 10109 62600807
Hepatosplenic T-cell lymphoma 29.50 11.41 39 878067 564 62610352
Carotid artery occlusion 29.45 11.41 14 878092 4680 62606236
Lung diffusion test decreased 29.41 11.41 42 878064 656 62610260
Metastases to lymph nodes 29.33 11.41 42 878064 8116 62602800
Long QT syndrome 29.33 11.41 5 878101 3274 62607642
Pleural mesothelioma malignant 29.25 11.41 15 878091 45 62610871
Atrial tachycardia 29.24 11.41 11 878095 4229 62606687
Urine output decreased 29.01 11.41 72 878034 11298 62599618
Herpes simplex 28.99 11.41 205 877901 8066 62602850
Temporal lobe epilepsy 28.98 11.41 32 878074 379 62610537
Respiratory acidosis 28.98 11.41 30 878076 6685 62604231
Amylase increased 28.93 11.41 27 878079 6318 62604598
Fibromyalgia 28.88 11.41 1375 876731 79045 62531871
COVID-19 28.87 11.41 1874 876232 111229 62499687
Respiratory tract infection 28.85 11.41 765 877341 40718 62570198
Atrial septal defect 28.82 11.41 32 878074 6906 62604010
Haematotoxicity 28.67 11.41 225 877881 9151 62601765
Head injury 28.42 11.41 242 877864 27154 62583762
COVID-19 pneumonia 28.28 11.41 311 877795 13898 62597018
Rash maculo-papular 28.26 11.41 293 877813 31603 62579313
Granulomatosis with polyangiitis 28.23 11.41 82 878024 2183 62608733
Lower respiratory tract congestion 28.17 11.41 96 878010 2790 62608126
Hypervolaemia 28.14 11.41 254 877852 28159 62582757
Symptom masked 28.13 11.41 43 878063 716 62610200
Lip swelling 28.08 11.41 284 877822 30779 62580137
Microsporidia infection 27.95 11.41 27 878079 270 62610646
Cholelithiasis 27.90 11.41 433 877673 43492 62567424
Polyuria 27.82 11.41 47 878059 8495 62602421
Serum sickness 27.79 11.41 95 878011 2765 62608151
Epstein-Barr virus associated lymphoma 27.68 11.41 35 878071 483 62610433
Paranasal sinus discomfort 27.65 11.41 127 877979 4249 62606667
Ammonia increased 27.54 11.41 15 878091 4641 62606275
Glycosylated haemoglobin increased 27.54 11.41 84 878022 12314 62598602
Pulmonary oedema 27.53 11.41 564 877542 54309 62556607
Thinking abnormal 27.47 11.41 67 878039 10576 62600340
Joint destruction 27.44 11.41 164 877942 6088 62604828
Bronchopulmonary aspergillosis allergic 27.43 11.41 81 878025 2177 62608739
Pseudomonas infection 27.40 11.41 256 877850 10957 62599959
Contusion 27.40 11.41 2421 875685 147623 62463293
International normalised ratio fluctuation 27.39 11.41 86 878020 2392 62608524
Pyoderma gangrenosum 27.36 11.41 111 877995 3514 62607402
Somnambulism 27.20 11.41 22 878084 5521 62605395
Device deployment issue 27.11 11.41 10 878096 3892 62607024
Feeling hot 26.94 11.41 512 877594 49842 62561074
Disability assessment scale score increased 26.83 11.41 102 878004 3131 62607785
Electrocardiogram abnormal 26.80 11.41 54 878052 9125 62601791
Alveolar osteitis 26.54 11.41 46 878060 855 62610061
Ileus 26.53 11.41 109 877997 14616 62596300
Joint range of motion decreased 26.43 11.41 611 877495 31817 62579099
Therapy interrupted 26.42 11.41 304 877802 32151 62578765
Emphysema 26.37 11.41 249 877857 10689 62600227
Bedridden 26.35 11.41 251 877855 10800 62600116
Malacoplakia 26.27 11.41 21 878085 159 62610757
Tinnitus 26.24 11.41 341 877765 35287 62575629
Asphyxia 26.24 11.41 28 878078 6153 62604763
Graft loss 26.23 11.41 29 878077 344 62610572
Disseminated strongyloidiasis 26.20 11.41 11 878095 17 62610899
Hyperreflexia 26.19 11.41 26 878080 5908 62605008
Blood potassium decreased 26.12 11.41 416 877690 41610 62569306
Ventricular septal defect 26.05 11.41 14 878092 4364 62606552
Blood glucose decreased 26.03 11.41 176 877930 20776 62590140
Tuberculosis 25.93 11.41 253 877853 10958 62599958
Petit mal epilepsy 25.90 11.41 10 878096 3784 62607132
Mucormycosis 25.86 11.41 93 878013 2778 62608138
Philadelphia positive chronic myeloid leukaemia 25.83 11.41 13 878093 37 62610879
Glomerular filtration rate decreased 25.81 11.41 97 878009 13344 62597572
Giant cell arteritis 25.78 11.41 80 878026 2211 62608705
Panic attack 25.59 11.41 192 877914 22139 62588777
Influenza 25.54 11.41 1789 876317 106933 62503983
Cat scratch disease 25.51 11.41 23 878083 209 62610707
Face oedema 25.50 11.41 169 877937 20043 62590873
Oral pain 25.50 11.41 260 877846 28134 62582782
Abdominal pain upper 25.48 11.41 2483 875623 203961 62406955
Cytopenia 25.48 11.41 259 877847 11342 62599574
Product physical issue 25.41 11.41 19 878087 4961 62605955
Hepatic encephalopathy 25.37 11.41 76 878030 11206 62599710
Hemiparesis 25.36 11.41 203 877903 23079 62587837
Hypoglycaemic coma 25.19 11.41 3 878103 2572 62608344
Tractional retinal detachment 25.12 11.41 13 878093 40 62610876
Disseminated tuberculosis 25.08 11.41 92 878014 2775 62608141
Immunosuppression 25.04 11.41 208 877898 8606 62602310
New onset diabetes after transplantation 25.00 11.41 17 878089 97 62610819
Shock 24.90 11.41 206 877900 23257 62587659
Scleroderma renal crisis 24.89 11.41 27 878079 313 62610603
Flatulence 24.88 11.41 334 877772 34368 62576548
Bradypnoea 24.83 11.41 9 878097 3541 62607375
Heart rate decreased 24.82 11.41 815 877291 44745 62566171
Application site pruritus 24.81 11.41 12 878094 3972 62606944
Faeces discoloured 24.77 11.41 152 877954 18357 62592559
Steroid withdrawal syndrome 24.76 11.41 34 878072 511 62610405
Fistula 2