prednisone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2253 53-03-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednisone anhydrous
  • prednisone
  • 1,2-dehydrocortisone
  • dehydrocortisone
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
  • Molecular weight: 358.43
  • Formula: C21H26O5
  • CLOGP: 1.66
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 91.67
  • ALOGS: -3.51
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.12 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 3 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 7.97 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.57 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.27 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 21, 1955 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1901.88 11.41 7742 870364 246077 62364839
Completed suicide 1613.56 11.41 101 878005 145572 62465344
Drug ineffective 1499.44 11.41 21444 856662 1023321 61587595
Death 971.32 11.41 2356 875750 372025 62238891
Toxicity to various agents 957.45 11.41 1208 876898 246042 62364874
Joint swelling 827.38 11.41 7524 870582 320142 62290774
Contraindicated product administered 767.97 11.41 5398 872708 212250 62398666
Intentional overdose 697.97 11.41 98 878008 74054 62536862
Systemic lupus erythematosus 663.28 11.41 5053 873053 203865 62407051
Treatment failure 641.29 11.41 4831 873275 194212 62416704
Overdose 615.53 11.41 418 877688 114660 62496256
Arthralgia 614.72 11.41 11173 866933 558537 62052379
Drug abuse 581.86 11.41 143 877963 72375 62538541
Pemphigus 567.57 11.41 4416 873690 179310 62431606
Therapeutic product effect incomplete 564.19 11.41 3302 874804 121754 62489162
Constipation 550.41 11.41 1457 876649 223486 62387430
Asthma 549.09 11.41 3327 874779 124234 62486682
Condition aggravated 539.21 11.41 8176 869930 394041 62216875
Off label use 538.50 11.41 12652 865454 661810 61949106
Colitis ulcerative 534.84 11.41 1142 876964 24949 62585967
Arthropathy 505.85 11.41 5217 872889 229575 62381341
Drug interaction 478.35 11.41 1598 876508 227533 62383383
Electrocardiogram QT prolonged 472.53 11.41 120 877986 59410 62551506
Depressed level of consciousness 466.79 11.41 139 877967 61939 62548977
Swelling 458.34 11.41 5819 872287 269559 62341357
Therapeutic product effect decreased 456.42 11.41 4376 873730 188811 62422105
Loss of personal independence in daily activities 442.66 11.41 2575 875531 94715 62516201
Drug intolerance 442.09 11.41 6348 871758 302313 62308603
Hyponatraemia 440.72 11.41 539 877567 111361 62499555
Suicide attempt 435.68 11.41 149 877957 60769 62550147
Glossodynia 429.53 11.41 4066 874040 174810 62436106
Acute kidney injury 419.35 11.41 2044 876062 261371 62349545
Post transplant lymphoproliferative disorder 419.16 11.41 428 877678 4603 62606313
Pain 413.63 11.41 13269 864837 727359 61883557
Bradycardia 410.58 11.41 252 877854 72975 62537941
Wheezing 403.46 11.41 2481 875625 93114 62517802
Hand deformity 402.62 11.41 3664 874442 155793 62455123
Fall 390.18 11.41 3508 874598 388826 62222090
Hypotension 383.36 11.41 2206 875900 270398 62340518
Synovitis 368.60 11.41 4081 874025 182837 62428079
Nausea 357.08 11.41 9051 869055 845420 61765496
Device expulsion 356.25 11.41 35 878071 34887 62576029
Seizure 355.58 11.41 819 877287 131815 62479101
Dizziness 351.87 11.41 4027 874079 425898 62185018
Obstructive airways disorder 344.21 11.41 834 877272 19865 62591051
Intentional product use issue 326.96 11.41 2947 875159 124945 62485971
Malignant neoplasm progression 321.80 11.41 397 877709 81724 62529192
Vomiting 319.28 11.41 5634 872472 553983 62056933
Anaemia 316.39 11.41 2568 875538 290862 62320054
Musculoskeletal stiffness 312.25 11.41 3914 874192 180704 62430212
Somnolence 296.78 11.41 1365 876741 177320 62433596
Cardiac arrest 291.00 11.41 521 877585 92024 62518892
Infusion related reaction 289.88 11.41 4889 873217 240632 62370284
Abdominal discomfort 288.24 11.41 6126 871980 314759 62296157
Cardio-respiratory arrest 282.11 11.41 248 877858 59711 62551205
Alopecia 277.87 11.41 6364 871742 331172 62279744
Sleep disorder due to a general medical condition 264.35 11.41 546 877560 11642 62599274
Dehydration 263.73 11.41 1366 876740 171988 62438928
White blood cell count decreased 263.54 11.41 1010 877096 138094 62472822
Cognitive disorder 262.43 11.41 231 877875 55584 62555332
Hypoglycaemia 259.73 11.41 268 877838 59797 62551119
Sedation 254.10 11.41 109 877997 38700 62572216
Decreased appetite 251.71 11.41 2239 875867 248813 62362103
Wound 247.86 11.41 3394 874712 159869 62451047
Hypokalaemia 241.91 11.41 688 877418 103116 62507800
Nocardiosis 239.47 11.41 207 877899 1769 62609147
Intentional self-injury 239.22 11.41 35 878071 25652 62585264
Rhabdomyolysis 237.11 11.41 158 877948 43793 62567123
Loss of consciousness 228.70 11.41 850 877256 117271 62493645
Product use issue 219.97 11.41 4277 873829 216243 62394673
Peripheral swelling 219.23 11.41 5016 873090 260926 62349990
Serotonin syndrome 217.84 11.41 63 878043 28619 62582297
Orthostatic hypotension 217.64 11.41 114 877992 36046 62574870
Balance disorder 214.53 11.41 536 877570 83886 62527030
Tremor 213.13 11.41 1021 877085 131218 62479698
Epstein-Barr virus infection 210.28 11.41 390 877716 7660 62603256
Hepatic function abnormal 207.92 11.41 128 877978 37014 62573902
Anti-cyclic citrullinated peptide antibody positive 207.68 11.41 2490 875616 113722 62497194
Histoplasmosis disseminated 206.42 11.41 167 877939 1289 62609627
Lactic acidosis 204.71 11.41 139 877967 38148 62572768
Pericarditis 202.38 11.41 2742 875364 128837 62482079
Suicidal ideation 201.12 11.41 346 877760 62075 62548841
Weight increased 200.28 11.41 4871 873235 255921 62354995
Cytomegalovirus infection 198.49 11.41 690 877416 20262 62590654
Full blood count abnormal 195.01 11.41 913 877193 30804 62580112
Discomfort 194.83 11.41 3326 874780 164048 62446868
Neutrophil count decreased 191.66 11.41 302 877804 56104 62554812
Respiratory arrest 190.52 11.41 107 877999 32538 62578378
Hallucination 189.59 11.41 290 877816 54527 62556389
Hyperkalaemia 189.16 11.41 285 877821 53918 62556998
Drug withdrawal syndrome 188.47 11.41 70 878036 27124 62583792
Agitation 186.41 11.41 338 877768 59419 62551497
Metabolic acidosis 186.05 11.41 209 877897 44860 62566056
Inflammation 183.89 11.41 1843 876263 80430 62530486
Blood pressure fluctuation 180.97 11.41 1179 876927 45138 62565778
Pneumocystis jirovecii pneumonia 178.82 11.41 578 877528 16336 62594580
Strongyloidiasis 178.75 11.41 144 877962 1104 62609812
Osteoporosis 178.27 11.41 1381 876725 55957 62554959
Product use in unapproved indication 177.39 11.41 3470 874636 175610 62435306
Diarrhoea 172.93 11.41 8112 869994 707254 61903662
Wrong technique in product usage process 172.65 11.41 378 877728 61962 62548954
Lower respiratory tract infection 171.73 11.41 2677 875429 129630 62481286
Multiple sclerosis relapse 170.04 11.41 254 877852 48224 62562692
Syncope 169.56 11.41 941 877165 116444 62494472
Aspergillus infection 169.03 11.41 357 877749 7736 62603180
Productive cough 168.88 11.41 1471 876635 61737 62549179
Intentional product misuse 168.18 11.41 370 877736 60547 62550369
Sputum discoloured 166.87 11.41 552 877554 15795 62595121
Sinusitis 164.62 11.41 4202 873904 222451 62388465
Forced expiratory volume decreased 164.14 11.41 267 877839 4701 62606215
Transplant rejection 162.05 11.41 418 877688 10362 62600554
Infection 157.53 11.41 4218 873888 224955 62385961
Red blood cell sedimentation rate increased 157.12 11.41 1095 877011 42887 62568029
Palmar-plantar erythrodysaesthesia syndrome 156.57 11.41 61 878045 22954 62587962
Arthritis 156.01 11.41 2360 875746 113561 62497355
Dyskinesia 155.87 11.41 128 877978 31874 62579042
Lethargy 154.76 11.41 340 877766 55667 62555249
Hypersensitivity 154.29 11.41 5213 872893 287472 62323444
Blood calcium decreased 153.93 11.41 87 878019 26364 62584552
Platelet count decreased 153.83 11.41 957 877149 115165 62495751
Neutropenia 151.96 11.41 1616 876490 173389 62437527
Cushingoid 150.94 11.41 351 877755 8134 62602782
Gastrointestinal haemorrhage 150.73 11.41 594 877512 80582 62530334
Unresponsive to stimuli 150.62 11.41 147 877959 33669 62577247
Cerebrovascular accident 150.59 11.41 876 877230 107148 62503768
Creatinine renal clearance decreased 147.80 11.41 24 878082 16284 62594632
International normalised ratio increased 146.22 11.41 261 877845 46164 62564752
Ill-defined disorder 145.26 11.41 1750 876356 80005 62530911
Blood pressure systolic increased 144.81 11.41 1137 876969 46260 62564656
Smooth muscle cell neoplasm 144.30 11.41 108 877998 733 62610183
Trichodysplasia spinulosa 143.36 11.41 93 878013 484 62610432
Kidney transplant rejection 143.10 11.41 231 877875 4040 62606876
Product dose omission issue 142.80 11.41 2329 875777 231984 62378932
Polyomavirus-associated nephropathy 142.79 11.41 151 877955 1697 62609219
Sopor 139.22 11.41 66 878040 22098 62588818
Disease recurrence 137.33 11.41 757 877349 27273 62583643
Neuropathy peripheral 135.87 11.41 966 877140 112701 62498215
Tachycardia 135.53 11.41 1016 877090 117140 62493776
Hyperhidrosis 133.54 11.41 907 877199 106929 62503987
C-reactive protein abnormal 132.77 11.41 1091 877015 45005 62565911
Faecal calprotectin increased 132.42 11.41 191 877915 3012 62607904
Nasopharyngitis 131.78 11.41 4520 873586 249737 62361179
Poisoning 131.51 11.41 17 878089 13683 62597233
Cytomegalovirus viraemia 129.55 11.41 259 877847 5390 62605526
Histoplasmosis 127.96 11.41 147 877959 1824 62609092
Disturbance in attention 127.34 11.41 207 877899 37982 62572934
Product quality issue 126.67 11.41 187 877919 35678 62575238
Depression 124.06 11.41 1940 876166 194552 62416364
Cardiac failure congestive 123.85 11.41 759 877347 91674 62519242
Hepatic enzyme increased 123.67 11.41 3669 874437 198659 62412257
Product substitution issue 123.58 11.41 34 878072 15962 62594954
Metastases to liver 123.48 11.41 88 878018 23551 62587365
Muscle spasms 122.91 11.41 1474 876632 154676 62456240
Aggression 122.06 11.41 88 878018 23410 62587506
Device dislocation 121.28 11.41 106 878000 25599 62585317
Metastases to bone 121.07 11.41 70 878036 20949 62589967
Neuroleptic malignant syndrome 120.59 11.41 13 878093 12043 62598873
Dysarthria 119.90 11.41 257 877849 42454 62568462
Circulatory collapse 118.14 11.41 79 878027 21859 62589057
Dysgeusia 117.53 11.41 298 877808 46412 62564504
Maternal exposure during pregnancy 117.52 11.41 3926 874180 216136 62394780
Hypomagnesaemia 116.72 11.41 135 877971 28602 62582314
Red blood cell sedimentation rate abnormal 116.19 11.41 562 877544 19220 62591696
Altered state of consciousness 115.50 11.41 107 877999 25123 62585793
Palpitations 115.39 11.41 1000 877106 111770 62499146
Renal failure 113.09 11.41 1060 877046 116592 62494324
Coma 112.59 11.41 482 877624 63882 62547034
Muscle injury 112.28 11.41 1390 876716 63955 62546961
Gastrointestinal disorder 112.22 11.41 2489 875617 128750 62482166
Cardiac failure 111.25 11.41 748 877358 88394 62522522
Haematemesis 109.93 11.41 156 877950 30256 62580660
Rheumatoid factor positive 108.39 11.41 1705 876401 82701 62528215
Melaena 107.55 11.41 158 877948 30207 62580709
Poisoning deliberate 107.49 11.41 14 878092 11204 62599712
Rebound effect 106.79 11.41 210 877896 4316 62606600
Nasal polyps 106.53 11.41 249 877857 5790 62605126
Frequent bowel movements 106.33 11.41 612 877494 22410 62588506
Impaired healing 105.55 11.41 1999 876107 100543 62510373
Varicella zoster virus infection 104.87 11.41 156 877950 2533 62608383
Cryptococcosis 104.79 11.41 103 878003 1054 62609862
Transient ischaemic attack 104.45 11.41 229 877877 37524 62573392
Folliculitis 104.22 11.41 1456 876650 68861 62542055
Cough 103.75 11.41 4997 873109 287746 62323170
Brain abscess 103.64 11.41 137 877969 1981 62608935
Anxiety 102.64 11.41 2259 875847 215282 62395634
Blood alkaline phosphatase increased 102.12 11.41 282 877824 42685 62568231
Phaeohyphomycosis 100.51 11.41 59 878047 248 62610668
Psoriatic arthropathy 99.71 11.41 1800 876306 89720 62521196
Device difficult to use 99.23 11.41 27 878079 12769 62598147
Accidental exposure to product 98.64 11.41 141 877965 27264 62583652
Atrial fibrillation 97.60 11.41 1086 877020 115550 62495366
Memory impairment 97.35 11.41 946 877160 103312 62507604
Oedema peripheral 97.30 11.41 1941 876165 187570 62423346
Haemophagocytic lymphohistiocytosis 97.23 11.41 346 877760 10281 62600635
Confusional state 97.06 11.41 2507 875599 233873 62377043
Rheumatoid nodule 96.92 11.41 482 877624 16673 62594243
Mucous stools 96.50 11.41 194 877912 4054 62606862
Epistaxis 95.95 11.41 600 877506 72125 62538791
Respiratory depression 95.55 11.41 35 878071 13680 62597236
Helicobacter infection 94.87 11.41 1807 876299 90978 62519938
Duodenal ulcer perforation 93.88 11.41 1712 876394 85497 62525419
Paraesthesia 93.65 11.41 1566 876540 155400 62455516
Amnesia 92.54 11.41 424 877682 55161 62555755
Drug level below therapeutic 91.77 11.41 206 877900 4660 62606256
Sensitivity to weather change 91.18 11.41 263 877843 6974 62603942
Diffuse large B-cell lymphoma recurrent 91.06 11.41 135 877971 2185 62608731
Ascites 90.45 11.41 276 877830 40452 62570464
Cerebral haemorrhage 88.69 11.41 182 877924 30547 62580369
Dystonia 88.58 11.41 40 878066 13779 62597137
Epidermodysplasia verruciformis 88.40 11.41 41 878065 91 62610825
Mobility decreased 88.07 11.41 2247 875859 118912 62492004
Blood creatine phosphokinase increased 88.02 11.41 180 877926 30250 62580666
Urinary retention 87.85 11.41 179 877927 30122 62580794
Thrombocytopenia 87.59 11.41 1516 876590 149641 62461275
Respiratory disorder 87.54 11.41 876 877230 38206 62572710
Hepatitis B reactivation 87.03 11.41 156 877950 2981 62607935
Irritable bowel syndrome 86.67 11.41 1612 876494 80800 62530116
Gamma-glutamyltransferase increased 86.47 11.41 216 877890 33815 62577101
Epilepsy 86.27 11.41 151 877955 26914 62584002
Arrhythmia 85.74 11.41 257 877849 37883 62573033
Labelled drug-drug interaction medication error 85.55 11.41 39 878067 13360 62597556
Tardive dyskinesia 85.47 11.41 9 878097 8493 62602423
Therapeutic response shortened 85.00 11.41 358 877748 11530 62599386
Eosinophilic bronchitis 83.95 11.41 67 878039 506 62610410
Blood glucose increased 83.77 11.41 747 877359 83009 62527907
Myocardial infarction 83.61 11.41 930 877176 98963 62511953
Torsade de pointes 83.48 11.41 40 878066 13311 62597605
Vaginal haemorrhage 83.47 11.41 158 877948 27329 62583587
Blood pressure diastolic abnormal 82.45 11.41 409 877697 14133 62596783
Muscle rigidity 82.43 11.41 28 878078 11472 62599444
Steroid diabetes 82.31 11.41 96 878010 1212 62609704
Therapeutic reaction time decreased 81.89 11.41 130 877976 2240 62608676
Withdrawal syndrome 81.15 11.41 94 878012 19903 62591013
Metastases to central nervous system 80.82 11.41 40 878066 13065 62597851
Alanine aminotransferase increased 80.69 11.41 982 877124 102788 62508128
Limb deformity 80.65 11.41 174 877932 3828 62607088
Product administration error 79.85 11.41 116 877990 22281 62588635
Disorientation 79.55 11.41 279 877827 39173 62571743
Full blood count decreased 79.55 11.41 149 877957 25875 62585041
Akathisia 79.52 11.41 15 878091 9131 62601785
Hallucination, auditory 79.31 11.41 39 878067 12785 62598131
Aspartate aminotransferase increased 78.55 11.41 833 877273 89444 62521472
Skin ulcer 78.45 11.41 926 877180 42119 62568797
Hallucination, visual 78.01 11.41 91 878015 19207 62591709
Respiratory tract congestion 77.81 11.41 467 877639 17365 62593551
Mycobacterial infection 77.66 11.41 109 877997 1674 62609242
Suspected suicide 77.61 11.41 3 878103 6565 62604351
Sensitisation 77.35 11.41 155 877951 3231 62607685
Plasma cell myeloma 77.13 11.41 247 877859 35658 62575258
Steroid dependence 77.07 11.41 108 877998 1656 62609260
Adrenal insufficiency 76.79 11.41 467 877639 17448 62593468
Subdural haematoma 76.61 11.41 52 878054 14276 62596640
Product prescribing error 76.47 11.41 155 877951 26134 62584782
Cytomegalovirus colitis 76.36 11.41 126 877980 2246 62608670
Polyarthritis 76.05 11.41 310 877796 9836 62601080
Mydriasis 76.02 11.41 35 878071 11921 62598995
Ventricular tachycardia 75.72 11.41 99 878007 19880 62591036
Generalised tonic-clonic seizure 75.43 11.41 182 877924 28834 62582082
Vision blurred 75.28 11.41 860 877246 91064 62519852
Foetal exposure during pregnancy 75.04 11.41 211 877895 31751 62579165
Renal impairment 74.97 11.41 820 877286 87535 62523381
Neutropenic sepsis 74.91 11.41 70 878036 16368 62594548
Diabetic ketoacidosis 74.29 11.41 105 878001 20400 62590516
Flushing 73.64 11.41 673 877433 74414 62536502
Drug reaction with eosinophilia and systemic symptoms 72.52 11.41 233 877873 33603 62577313
Haematoma 72.40 11.41 243 877863 34577 62576339
Sinus bradycardia 72.36 11.41 57 878049 14494 62596422
Diffuse large B-cell lymphoma 71.52 11.41 230 877876 6482 62604434
Cerebral infarction 71.11 11.41 139 877967 23754 62587162
Stevens-Johnson syndrome 70.97 11.41 149 877957 24801 62586115
Accidental overdose 70.76 11.41 134 877972 23175 62587741
Therapy partial responder 70.11 11.41 313 877793 10345 62600571
Deformity 70.11 11.41 334 877772 11350 62599566
Bronchiectasis 69.96 11.41 422 877684 15720 62595196
Restlessness 69.47 11.41 194 877912 29259 62581657
Dementia 69.33 11.41 95 878011 18699 62592217
Blood immunoglobulin E increased 69.32 11.41 160 877946 3689 62607227
Delusion 69.24 11.41 40 878066 11977 62598939
Medication error 69.15 11.41 431 877675 51853 62559063
Meningitis cryptococcal 68.82 11.41 90 878016 1287 62609629
Vaccination failure 68.28 11.41 68 878038 708 62610208
Neoplasm progression 67.96 11.41 266 877840 36162 62574754
Haematochezia 67.74 11.41 1079 877027 52465 62558451
West Nile viral infection 67.70 11.41 51 878055 350 62610566
Blood bilirubin increased 67.51 11.41 274 877832 36866 62574050
Renal transplant failure 67.46 11.41 67 878039 695 62610221
Parkinsonism 67.25 11.41 30 878076 10409 62600507
Blood pressure systolic abnormal 67.24 11.41 364 877742 13022 62597894
Dry skin 67.20 11.41 485 877621 56402 62554514
Complication of device insertion 66.64 11.41 12 878094 7552 62603364
Contrast media allergy 66.10 11.41 119 877987 2282 62608634
Blood pressure diastolic decreased 65.69 11.41 538 877568 22168 62588748
Hypothermia 65.29 11.41 55 878051 13526 62597390
Breast cancer stage I 65.05 11.41 9 878097 6880 62604036
Abnormal dreams 65.00 11.41 32 878074 10484 62600432
Impaired quality of life 64.70 11.41 368 877738 13415 62597501
Epidural lipomatosis 64.61 11.41 32 878074 87 62610829
Sleep disorder due to general medical condition, insomnia type 64.47 11.41 1048 877058 51169 62559747
Hypophagia 64.41 11.41 219 877887 31040 62579876
Obliterative bronchiolitis 64.39 11.41 109 877997 1986 62608930
Fluid retention 63.85 11.41 523 877583 59163 62551753
Panniculitis 63.69 11.41 319 877787 11066 62599850
Acute myocardial infarction 63.55 11.41 229 877877 31895 62579021
Ventricular fibrillation 63.54 11.41 43 878063 11824 62599092
Blister 63.48 11.41 2293 875813 127521 62483395
Immunosuppressant drug level increased 63.08 11.41 149 877957 3489 62607427
Heart rate increased 63.07 11.41 1729 876377 92509 62518407
Temperature regulation disorder 62.92 11.41 6 878100 6126 62604790
Knee arthroplasty 62.55 11.41 1076 877030 53130 62557786
Infection reactivation 62.48 11.41 80 878026 1119 62609797
Therapeutic response decreased 62.46 11.41 1197 876909 60328 62550588
C-reactive protein increased 62.36 11.41 1734 876372 92973 62517943
Body temperature increased 62.10 11.41 787 877319 36405 62574511
Complications of transplanted kidney 61.89 11.41 118 877988 2368 62608548
Breast cancer 61.85 11.41 403 877703 47980 62562936
Complication associated with device 61.45 11.41 87 878019 16891 62594025
Drug specific antibody 61.39 11.41 114 877992 2241 62608675
Inappropriate antidiuretic hormone secretion 61.33 11.41 74 878032 15388 62595528
BK virus infection 60.93 11.41 138 877968 3141 62607775
Jaundice 60.91 11.41 204 877902 29047 62581869
Dust allergy 60.67 11.41 61 878045 643 62610273
Hepatic failure 60.53 11.41 270 877836 35386 62575530
Anal fissure 60.42 11.41 166 877940 4277 62606639
Coronary artery disease 60.03 11.41 237 877869 32140 62578776
Extrapyramidal disorder 60.03 11.41 57 878049 13227 62597689
Breast cancer metastatic 59.86 11.41 47 878059 11971 62598945
Disseminated cryptococcosis 59.79 11.41 49 878057 386 62610530
Liver function test abnormal 59.74 11.41 405 877701 47776 62563140
Pallor 59.09 11.41 220 877886 30348 62580568
Mental status changes 59.04 11.41 314 877792 39285 62571631
Chest pain 59.02 11.41 2414 875692 213545 62397371
Incorrect product administration duration 58.98 11.41 44 878062 11502 62599414
Breath sounds abnormal 58.97 11.41 304 877802 10669 62600247
Rash 58.65 11.41 8726 869380 552145 62058771
Exposure to toxic agent 58.59 11.41 5 878101 5582 62605334
Mycobacterium avium complex infection 58.54 11.41 131 877975 2957 62607959
Myalgia 58.52 11.41 1560 876546 144969 62465947
Abnormal behaviour 58.42 11.41 131 877975 21295 62589621
Blood urea increased 58.40 11.41 179 877927 26200 62584716
Joint injury 58.31 11.41 646 877460 28926 62581990
Ear pain 58.08 11.41 759 877347 35359 62575557
Hip arthroplasty 57.98 11.41 954 877152 46692 62564224
Hypocalcaemia 57.62 11.41 234 877872 31479 62579437
Restless legs syndrome 57.61 11.41 105 878001 18426 62592490
Angioedema 57.59 11.41 407 877699 47558 62563358
Chronic allograft nephropathy 57.16 11.41 60 878046 668 62610248
Septic shock 57.02 11.41 1264 876842 65365 62545551
Polymyalgia rheumatica 56.98 11.41 147 877959 3644 62607272
Humoral immune defect 56.89 11.41 39 878067 226 62610690
Osteoporotic fracture 56.04 11.41 145 877961 3601 62607315
Rhinitis allergic 55.64 11.41 314 877792 11413 62599503
Poor venous access 55.10 11.41 372 877734 14413 62596503
Device issue 55.08 11.41 158 877948 23623 62587293
Urinary incontinence 54.60 11.41 242 877864 31772 62579144
Salivary hypersecretion 54.37 11.41 19 878087 7647 62603269
Herpes zoster 54.34 11.41 1510 876596 80952 62529964
Nightmare 54.28 11.41 115 877991 19079 62591837
Metastases to lung 53.86 11.41 58 878048 12692 62598224
Myoclonus 53.85 11.41 85 878021 15783 62595133
Sarcoidosis 53.69 11.41 218 877888 6904 62604012
Breast cancer female 53.67 11.41 65 878041 13494 62597422
Cytomegalovirus gastrointestinal infection 53.62 11.41 40 878066 270 62610646
Eosinophil count increased 53.44 11.41 295 877811 10633 62600283
Atrioventricular block first degree 53.37 11.41 17 878089 7256 62603660
Lupus nephritis 53.33 11.41 120 877986 2719 62608197
Joint stiffness 53.06 11.41 844 877262 41025 62569891
Treatment noncompliance 52.89 11.41 301 877805 37024 62573892
Device adhesion issue 52.83 11.41 5 878101 5136 62605780
Central nervous system lymphoma 52.74 11.41 83 878023 1419 62609497
Biopsy lung abnormal 52.69 11.41 31 878075 131 62610785
Delirium 52.64 11.41 446 877660 50095 62560821
Blood creatinine increased 52.48 11.41 876 877230 86968 62523948
Epstein-Barr virus associated lymphoproliferative disorder 52.30 11.41 94 878012 1800 62609116
Foot deformity 52 11.41 602 877504 27251 62583665
Depressed mood 51.76 11.41 334 877772 39857 62571059
Dysphagia 51.75 11.41 887 877219 87698 62523218
Impaired work ability 51.61 11.41 416 877690 17059 62593857
Uterine perforation 51.59 11.41 16 878090 6947 62603969
Bronchial wall thickening 51.49 11.41 82 878024 1417 62609499
Haemoglobin decreased 51.47 11.41 1575 876531 143910 62467006
Substance abuse 51.24 11.41 4 878102 4803 62606113
Defaecation urgency 50.94 11.41 150 877956 4025 62606891
Joint effusion 50.86 11.41 407 877699 16653 62594263
Miosis 50.83 11.41 19 878087 7334 62603582
Mental impairment 50.73 11.41 73 878033 14078 62596838
Toxic epidermal necrolysis 50.51 11.41 180 877926 25154 62585762
Granuloma skin 50.49 11.41 241 877865 8196 62602720
Skin exfoliation 50.17 11.41 369 877737 42733 62568183
Blood pressure diastolic increased 50.14 11.41 272 877834 9738 62601178
Aphasia 50.13 11.41 260 877846 32740 62578176
Unintended pregnancy 49.91 11.41 12 878094 6167 62604749
Bone pain 49.64 11.41 499 877607 54142 62556774
Bacillary angiomatosis 49.55 11.41 26 878080 83 62610833
Candida infection 49.51 11.41 605 877501 27746 62583170
Multiple sclerosis 49.37 11.41 172 877934 24200 62586716
Vasculitis 49.25 11.41 425 877681 17784 62593132
Upper gastrointestinal haemorrhage 49.20 11.41 118 877988 18734 62592182
Unintentional medical device removal 49.15 11.41 12 878094 6103 62604813
Genital haemorrhage 48.94 11.41 20 878086 7312 62603604
Device use error 48.93 11.41 10 878096 5751 62605165
Colectomy 48.78 11.41 110 877996 2496 62608420
Body height below normal 48.76 11.41 99 878007 2084 62608832
Musculoskeletal pain 48.59 11.41 1644 876462 90633 62520283
Ketoacidosis 48.54 11.41 3 878103 4375 62606541
Blood parathyroid hormone decreased 48.34 11.41 265 877841 9526 62601390
Osteonecrosis of jaw 48.29 11.41 286 877820 34837 62576079
Sexual dysfunction 48.29 11.41 3 878103 4356 62606560
Complication of device removal 47.89 11.41 7 878099 5135 62605781
Delayed graft function 47.87 11.41 67 878039 1026 62609890
Sickle cell anaemia with crisis 47.82 11.41 12 878094 5991 62604925
Cataract 47.77 11.41 1079 877027 55974 62554942
Pleural effusion 47.69 11.41 955 877151 92255 62518661
Uveitis 47.48 11.41 317 877789 12236 62598680
Product adhesion issue 47.42 11.41 5 878101 4714 62606202
Human antichimeric antibody positive 47.25 11.41 85 878021 1629 62609287
Liver transplant rejection 47.24 11.41 77 878029 1358 62609558
Tenosynovitis 47.24 11.41 340 877766 13455 62597461
Blood sodium decreased 47.24 11.41 174 877932 24078 62586838
Human polyomavirus infection 47.10 11.41 38 878068 292 62610624
Gastritis 47.03 11.41 312 877794 36991 62573925
Diabetes mellitus 46.89 11.41 1056 877050 54754 62556162
Feeling abnormal 46.67 11.41 1631 876475 146761 62464155
Coccidioidomycosis 46.62 11.41 62 878044 902 62610014
Hot flush 46.56 11.41 467 877639 50692 62560224
Bone density decreased 46.55 11.41 354 877752 14258 62596658
Posterior reversible encephalopathy syndrome 46.48 11.41 404 877702 16941 62593975
Ulcer 46.41 11.41 559 877547 25548 62585368
Acquired haemophilia 46.35 11.41 64 878042 967 62609949
Polyp 46.33 11.41 196 877910 6325 62604591
Lymphocyte count decreased 46.18 11.41 238 877868 30019 62580897
Renal graft infection 45.75 11.41 34 878072 228 62610688
Pre-existing disease 45.68 11.41 30 878076 160 62610756
Hypogammaglobulinaemia 45.47 11.41 208 877898 6947 62603969
Secondary immunodeficiency 45.25 11.41 74 878032 1309 62609607
Blood pressure decreased 45.13 11.41 630 877476 64392 62546524
Tumour marker increased 45.07 11.41 7 878099 4908 62606008
Crohn's disease 44.98 11.41 160 877946 4753 62606163
Disability 44.90 11.41 419 877687 17928 62592988
Pulmonary embolism 44.83 11.41 1249 876857 115435 62495481
Inappropriate schedule of product administration 44.53 11.41 1810 876296 102155 62508761
Wrist deformity 44.53 11.41 94 878012 2036 62608880
Asthenia 44.41 11.41 4636 873470 378968 62231948
Epstein-Barr viraemia 44.37 11.41 62 878044 948 62609968
Pruritus allergic 44.31 11.41 79 878027 1503 62609413
Eye infection toxoplasmal 44.30 11.41 35 878071 260 62610656
Caesarean section 44.14 11.41 107 877999 16925 62593991
Therapy non-responder 44.04 11.41 1368 876738 74533 62536383
Device breakage 43.94 11.41 57 878049 11485 62599431
Multiple-drug resistance 43.86 11.41 9 878097 5161 62605755
Drug level decreased 43.68 11.41 221 877885 7698 62603218
Heart transplant rejection 43.57 11.41 48 878058 567 62610349
Bronchopulmonary aspergillosis 43.50 11.41 235 877871 8400 62602516
Psychotic disorder 43.47 11.41 195 877911 25517 62585399
Swollen tongue 43.40 11.41 292 877814 34508 62576408
Listeriosis 42.66 11.41 76 878030 1445 62609471
Animal scratch 42.56 11.41 73 878033 1345 62609571
Vertigo 42.37 11.41 578 877528 59309 62551607
Aphthous ulcer 42.36 11.41 334 877772 13604 62597312
Pulmonary fibrosis 42.30 11.41 780 877326 39029 62571887
Hyperprolactinaemia 42.27 11.41 3 878103 3897 62607019
Ataxia 42.17 11.41 92 878014 15103 62595813
Personality change 41.93 11.41 22 878084 6951 62603965
Hypertonia 41.63 11.41 7 878099 4630 62606286
Granuloma 41.59 11.41 174 877932 5587 62605329
Ear pruritus 41.46 11.41 135 877971 3830 62607086
Acanthamoeba infection 41.32 11.41 19 878087 41 62610875
Herpes simplex hepatitis 41.23 11.41 39 878067 379 62610537
Heavy menstrual bleeding 41.23 11.41 118 877988 17655 62593261
Nasal congestion 41.22 11.41 1195 876911 64465 62546451
Systemic lupus erythematosus rash 40.98 11.41 94 878012 2158 62608758
Drug tolerance decreased 40.75 11.41 395 877711 17078 62593838
Cholecystitis chronic 40.66 11.41 50 878056 10311 62600605
Bradyphrenia 40.55 11.41 23 878083 6957 62603959
American trypanosomiasis 40.48 11.41 21 878085 65 62610851
Galactorrhoea 40.26 11.41 5 878101 4150 62606766
Chronic kidney disease 40.25 11.41 417 877689 44981 62565935
Schizophrenia 40.15 11.41 47 878059 9905 62601011
Nasal oedema 40.08 11.41 74 878032 1448 62609468
Toxic skin eruption 40.06 11.41 73 878033 12812 62598104
Sinus tachycardia 39.86 11.41 186 877920 24082 62586834
Mycobacterium chelonae infection 39.85 11.41 42 878064 470 62610446
Application site erythema 39.82 11.41 9 878097 4826 62606090
Ejection fraction decreased 39.81 11.41 166 877940 22166 62588750
Therapy cessation 39.79 11.41 252 877854 30205 62580711
Arthritis bacterial 39.69 11.41 186 877920 6277 62604639
Cyanosis 39.60 11.41 112 877994 16823 62594093
Clonus 39.47 11.41 8 878098 4628 62606288
Sensory disturbance 39.43 11.41 81 878025 13591 62597325
Euglycaemic diabetic ketoacidosis 39.33 11.41 3 878103 3671 62607245
Lupus-like syndrome 39.31 11.41 353 877753 14942 62595974
Abortion spontaneous 39.23 11.41 440 877666 46755 62564161
Finger deformity 39.17 11.41 211 877895 7534 62603382
Pseudohyponatraemia 39.14 11.41 17 878089 30 62610886
Multiple drug therapy 38.96 11.41 3 878103 3643 62607273
No adverse event 38.92 11.41 375 877731 41030 62569886
Oropharyngeal pain 38.87 11.41 1638 876468 92849 62518067
Wrist surgery 38.87 11.41 54 878052 821 62610095
Swollen joint count increased 38.85 11.41 708 877398 35346 62575570
Toxoplasmosis 38.80 11.41 73 878033 1450 62609466
Subarachnoid haemorrhage 38.39 11.41 88 878018 14195 62596721
Electrocardiogram QRS complex prolonged 38.35 11.41 17 878089 5921 62604995
Drug effective for unapproved indication 38.35 11.41 118 877988 3246 62607670
Blood test abnormal 38.28 11.41 357 877749 15272 62595644
Clostridium difficile infection 38.23 11.41 604 877502 29318 62581598
Musculoskeletal disorder 38.01 11.41 445 877661 20199 62590717
Ejection fraction 37.94 11.41 95 878011 2311 62608605
Lung transplant rejection 37.92 11.41 55 878051 872 62610044
Urticaria 37.91 11.41 2722 875384 163080 62447836
SARS-CoV-2 RNA increased 37.86 11.41 20 878086 65 62610851
Bloody discharge 37.85 11.41 73 878033 1478 62609438
Visual acuity reduced 37.82 11.41 164 877942 21662 62589254
Hypoxia 37.79 11.41 590 877516 59202 62551714
Neuroendocrine carcinoma of the skin 37.70 11.41 44 878062 556 62610360
Lung disorder 37.68 11.41 1128 876978 61133 62549783
Status epilepticus 37.68 11.41 98 878008 15135 62595781
Hypernatraemia 37.59 11.41 30 878076 7579 62603337
Ischaemic stroke 37.55 11.41 125 877981 17832 62593084
Irritability 37.53 11.41 270 877836 31424 62579492
Human herpesvirus 8 infection 37.44 11.41 30 878076 228 62610688
Rheumatic fever 37.24 11.41 819 877287 42292 62568624
Anaphylactic shock 37.15 11.41 184 877922 23449 62587467
Urinary tract infection 37.12 11.41 3153 874953 261531 62349385
Fear 37.07 11.41 104 878002 15662 62595254
Vital capacity decreased 36.99 11.41 77 878029 1651 62609265
Bronchial disorder 36.88 11.41 65 878041 1225 62609691
Hepatic cytolysis 36.69 11.41 101 878005 15306 62595610
Upper-airway cough syndrome 36.58 11.41 277 877829 11141 62599775
Visceral leishmaniasis 36.57 11.41 42 878064 521 62610395
Pulmonary nocardiosis 36.54 11.41 34 878072 323 62610593
Ventricular extrasystoles 36.53 11.41 66 878040 11621 62599295
Muscle twitching 36.44 11.41 144 877962 19524 62591392
Antipsychotic drug level increased 36.22 11.41 3 878103 3432 62607484
Acute generalised exanthematous pustulosis 36.22 11.41 61 878045 11038 62599878
Pregnancy with contraceptive device 36.22 11.41 10 878096 4684 62606232
Angina pectoris 36.21 11.41 255 877851 29823 62581093
Calciphylaxis 36.18 11.41 109 877997 2963 62607953
Eosinophilic granulomatosis with polyangiitis 36.09 11.41 88 878018 2104 62608812
Necrotising retinitis 36.06 11.41 36 878070 376 62610540
Alternaria infection 36.03 11.41 29 878077 222 62610694
Mucocutaneous leishmaniasis 36.00 11.41 35 878071 353 62610563
Lennox-Gastaut syndrome 35.57 11.41 30 878076 247 62610669
Blastomycosis 35.47 11.41 32 878074 291 62610625
Ileostomy 35.25 11.41 69 878037 1413 62609503
Schizoaffective disorder 35.22 11.41 4 878102 3558 62607358
Polyomavirus viraemia 35.18 11.41 47 878059 687 62610229
Pulmonary function test abnormal 35.10 11.41 78 878028 1752 62609164
Thirst 34.99 11.41 90 878016 13951 62596965
Visual impairment 34.76 11.41 895 877211 83551 62527365
Blood pressure increased 34.75 11.41 2647 875459 159415 62451501
Intermenstrual bleeding 34.67 11.41 35 878071 7891 62603025
Wheelchair user 34.61 11.41 176 877930 6143 62604773
Dry mouth 34.56 11.41 816 877290 77047 62533869
Scleritis 34.55 11.41 137 877969 4291 62606625
Dermatomyositis 34.44 11.41 102 878004 2746 62608170
Mycotic allergy 34.35 11.41 55 878051 955 62609961
Escherichia bacteraemia 34.31 11.41 125 877981 3758 62607158
Device occlusion 34.20 11.41 31 878075 7356 62603560
Respiratory symptom 34.14 11.41 113 877993 3234 62607682
Myopathy 33.91 11.41 268 877838 10923 62599993
Secretion discharge 33.88 11.41 287 877819 11944 62598972
Sinus pain 33.78 11.41 114 877992 3296 62607620
Coordination abnormal 33.77 11.41 89 878017 13684 62597232
Rhinorrhoea 33.68 11.41 1165 876941 64412 62546504
Prothrombin time prolonged 33.64 11.41 50 878056 9514 62601402
Device malfunction 33.56 11.41 130 877976 17727 62593189
Parvovirus B19 infection 33.53 11.41 40 878066 518 62610398
Sporotrichosis 33.50 11.41 16 878090 39 62610877
Mood altered 33.38 11.41 99 878007 14644 62596272
Apnoea 33.32 11.41 37 878069 7985 62602931
Bone swelling 33.28 11.41 73 878033 1625 62609291
Loose body in joint 33.21 11.41 62 878044 1224 62609692
Total lung capacity increased 33.11 11.41 88 878018 2222 62608694
Right ventricular failure 33.03 11.41 124 877982 17064 62593852
Pulmonary toxicity 32.94 11.41 234 877872 9221 62601695
Encephalopathy 32.92 11.41 358 877748 38262 62572654
Coma scale abnormal 32.90 11.41 15 878091 5138 62605778
Peak expiratory flow rate decreased 32.83 11.41 42 878064 587 62610329
Product preparation error 32.72 11.41 22 878084 6070 62604846
Faecaloma 32.58 11.41 37 878069 7904 62603012
Speech disorder 32.51 11.41 382 877724 40247 62570669
Laboratory test abnormal 32.48 11.41 228 877878 26684 62584232
Herpes simplex oesophagitis 32.28 11.41 24 878082 161 62610755
Hypotonia 32.21 11.41 49 878057 9236 62601680
Immobile 32.18 11.41 165 877941 5778 62605138
Mental disorder 32.06 11.41 218 877888 25701 62585215
Ovarian hyperstimulation syndrome 32.02 11.41 8 878098 4006 62606910
Therapy responder 31.94 11.41 31 878075 312 62610604
Drug specific antibody present 31.82 11.41 130 877976 4129 62606787
Presyncope 31.79 11.41 239 877867 27546 62583370
Electrolyte imbalance 31.73 11.41 156 877950 19920 62590996
Arthrodesis 31.70 11.41 98 878008 2703 62608213
Disseminated mycobacterium avium complex infection 31.69 11.41 21 878085 114 62610802
Rheumatoid lung 31.61 11.41 121 877985 3727 62607189
Human ehrlichiosis 31.56 11.41 23 878083 149 62610767
Femoral neck fracture 31.52 11.41 43 878063 8480 62602436
Drug screen positive 31.45 11.41 6 878100 3623 62607293
JC virus infection 31.31 11.41 80 878026 1971 62608945
Diplopia 31.16 11.41 196 877910 23532 62587384
Multifocal micronodular pneumocyte hyperplasia 31.15 11.41 18 878088 73 62610843
Bronchial polyp 31.15 11.41 18 878088 73 62610843
Pain in extremity 31.04 11.41 5127 872979 326359 62284557
Pre-engraftment immune reaction 31.03 11.41 26 878080 212 62610704
Tuberculin test positive 31.00 11.41 113 877993 3398 62607518
Cholestasis 30.98 11.41 259 877847 29175 62581741
Sudden death 30.91 11.41 61 878045 10388 62600528
Psychomotor hyperactivity 30.90 11.41 63 878043 10600 62600316
Nephrectomy 30.89 11.41 66 878040 1442 62609474
Hypertensive crisis 30.88 11.41 108 877998 15178 62595738
Myocardial ischaemia 30.85 11.41 84 878022 12775 62598141
Pneumonia aspiration 30.73 11.41 317 877789 34223 62576693
Episcleritis 30.70 11.41 52 878054 948 62609968
Type 2 diabetes mellitus 30.67 11.41 1126 876980 62742 62548174
Left ventricular dysfunction 30.52 11.41 76 878030 11912 62599004
Skin necrosis 30.42 11.41 311 877795 13639 62597277
Psychomotor retardation 30.32 11.41 8 878098 3862 62607054
Device leakage 30.28 11.41 32 878074 7064 62603852
Rash erythematous 30.17 11.41 410 877696 42100 62568816
Atrioventricular block complete 30.14 11.41 42 878064 8209 62602707
Pulmonary hypertension 30.11 11.41 348 877758 36775 62574141
Sputum purulent 30.08 11.41 54 878052 1033 62609883
Cerebral aspergillosis 30.01 11.41 33 878073 389 62610527
Polycystic ovaries 29.94 11.41 132 877974 4339 62606577
Nodule 29.79 11.41 432 877674 20594 62590322
Abortion incomplete 29.78 11.41 4 878102 3127 62607789
Product complaint 29.74 11.41 85 878021 12724 62598192
Urinary tract discomfort 29.72 11.41 41 878065 619 62610297
Deep vein thrombosis 29.67 11.41 907 877199 82893 62528023
Erythema multiforme 29.54 11.41 60 878046 10109 62600807
Hepatosplenic T-cell lymphoma 29.50 11.41 39 878067 564 62610352
Carotid artery occlusion 29.45 11.41 14 878092 4680 62606236
Lung diffusion test decreased 29.41 11.41 42 878064 656 62610260
Metastases to lymph nodes 29.33 11.41 42 878064 8116 62602800
Long QT syndrome 29.33 11.41 5 878101 3274 62607642
Pleural mesothelioma malignant 29.25 11.41 15 878091 45 62610871
Atrial tachycardia 29.24 11.41 11 878095 4229 62606687
Urine output decreased 29.01 11.41 72 878034 11298 62599618
Herpes simplex 28.99 11.41 205 877901 8066 62602850
Temporal lobe epilepsy 28.98 11.41 32 878074 379 62610537
Respiratory acidosis 28.98 11.41 30 878076 6685 62604231
Amylase increased 28.93 11.41 27 878079 6318 62604598
Fibromyalgia 28.88 11.41 1375 876731 79045 62531871
COVID-19 28.87 11.41 1874 876232 111229 62499687
Respiratory tract infection 28.85 11.41 765 877341 40718 62570198
Atrial septal defect 28.82 11.41 32 878074 6906 62604010
Haematotoxicity 28.67 11.41 225 877881 9151 62601765
Head injury 28.42 11.41 242 877864 27154 62583762
COVID-19 pneumonia 28.28 11.41 311 877795 13898 62597018
Rash maculo-papular 28.26 11.41 293 877813 31603 62579313
Granulomatosis with polyangiitis 28.23 11.41 82 878024 2183 62608733
Lower respiratory tract congestion 28.17 11.41 96 878010 2790 62608126
Hypervolaemia 28.14 11.41 254 877852 28159 62582757
Symptom masked 28.13 11.41 43 878063 716 62610200
Lip swelling 28.08 11.41 284 877822 30779 62580137
Microsporidia infection 27.95 11.41 27 878079 270 62610646
Cholelithiasis 27.90 11.41 433 877673 43492 62567424
Polyuria 27.82 11.41 47 878059 8495 62602421
Serum sickness 27.79 11.41 95 878011 2765 62608151
Epstein-Barr virus associated lymphoma 27.68 11.41 35 878071 483 62610433
Paranasal sinus discomfort 27.65 11.41 127 877979 4249 62606667
Ammonia increased 27.54 11.41 15 878091 4641 62606275
Glycosylated haemoglobin increased 27.54 11.41 84 878022 12314 62598602
Pulmonary oedema 27.53 11.41 564 877542 54309 62556607
Thinking abnormal 27.47 11.41 67 878039 10576 62600340
Joint destruction 27.44 11.41 164 877942 6088 62604828
Bronchopulmonary aspergillosis allergic 27.43 11.41 81 878025 2177 62608739
Pseudomonas infection 27.40 11.41 256 877850 10957 62599959
Contusion 27.40 11.41 2421 875685 147623 62463293
International normalised ratio fluctuation 27.39 11.41 86 878020 2392 62608524
Pyoderma gangrenosum 27.36 11.41 111 877995 3514 62607402
Somnambulism 27.20 11.41 22 878084 5521 62605395
Device deployment issue 27.11 11.41 10 878096 3892 62607024
Feeling hot 26.94 11.41 512 877594 49842 62561074
Disability assessment scale score increased 26.83 11.41 102 878004 3131 62607785
Electrocardiogram abnormal 26.80 11.41 54 878052 9125 62601791
Alveolar osteitis 26.54 11.41 46 878060 855 62610061
Ileus 26.53 11.41 109 877997 14616 62596300
Joint range of motion decreased 26.43 11.41 611 877495 31817 62579099
Therapy interrupted 26.42 11.41 304 877802 32151 62578765
Emphysema 26.37 11.41 249 877857 10689 62600227
Bedridden 26.35 11.41 251 877855 10800 62600116
Malacoplakia 26.27 11.41 21 878085 159 62610757
Tinnitus 26.24 11.41 341 877765 35287 62575629
Asphyxia 26.24 11.41 28 878078 6153 62604763
Graft loss 26.23 11.41 29 878077 344 62610572
Disseminated strongyloidiasis 26.20 11.41 11 878095 17 62610899
Hyperreflexia 26.19 11.41 26 878080 5908 62605008
Blood potassium decreased 26.12 11.41 416 877690 41610 62569306
Ventricular septal defect 26.05 11.41 14 878092 4364 62606552
Blood glucose decreased 26.03 11.41 176 877930 20776 62590140
Tuberculosis 25.93 11.41 253 877853 10958 62599958
Petit mal epilepsy 25.90 11.41 10 878096 3784 62607132
Mucormycosis 25.86 11.41 93 878013 2778 62608138
Philadelphia positive chronic myeloid leukaemia 25.83 11.41 13 878093 37 62610879
Glomerular filtration rate decreased 25.81 11.41 97 878009 13344 62597572
Giant cell arteritis 25.78 11.41 80 878026 2211 62608705
Panic attack 25.59 11.41 192 877914 22139 62588777
Influenza 25.54 11.41 1789 876317 106933 62503983
Cat scratch disease 25.51 11.41 23 878083 209 62610707
Face oedema 25.50 11.41 169 877937 20043 62590873
Oral pain 25.50 11.41 260 877846 28134 62582782
Abdominal pain upper 25.48 11.41 2483 875623 203961 62406955
Cytopenia 25.48 11.41 259 877847 11342 62599574
Product physical issue 25.41 11.41 19 878087 4961 62605955
Hepatic encephalopathy 25.37 11.41 76 878030 11206 62599710
Hemiparesis 25.36 11.41 203 877903 23079 62587837
Hypoglycaemic coma 25.19 11.41 3 878103 2572 62608344
Tractional retinal detachment 25.12 11.41 13 878093 40 62610876
Disseminated tuberculosis 25.08 11.41 92 878014 2775 62608141
Immunosuppression 25.04 11.41 208 877898 8606 62602310
New onset diabetes after transplantation 25.00 11.41 17 878089 97 62610819
Shock 24.90 11.41 206 877900 23257 62587659
Scleroderma renal crisis 24.89 11.41 27 878079 313 62610603
Flatulence 24.88 11.41 334 877772 34368 62576548
Bradypnoea 24.83 11.41 9 878097 3541 62607375
Heart rate decreased 24.82 11.41 815 877291 44745 62566171
Application site pruritus 24.81 11.41 12 878094 3972 62606944
Faeces discoloured 24.77 11.41 152 877954 18357 62592559
Steroid withdrawal syndrome 24.76 11.41 34 878072 511 62610405
Fistula 24.76 11.41 236 877870 10157 62600759
Injection site pain 24.54 11.41 1507 876599 128293 62482623
Disseminated blastomycosis 24.46 11.41 11 878095 22 62610894
Complications of transplanted lung 24.46 11.41 24 878082 245 62610671
Acidosis 24.32 11.41 77 878029 11156 62599760
Blood prolactin increased 24.30 11.41 9 878097 3494 62607422
Thrombotic microangiopathy 24.26 11.41 238 877868 10323 62600593
Focal segmental glomerulosclerosis 24.24 11.41 59 878047 1409 62609507
Diffuse large B-cell lymphoma refractory 24.24 11.41 53 878053 1177 62609739
Skin fragility 24.22 11.41 38 878068 648 62610268
Breast cancer stage II 24.15 11.41 53 878053 8683 62602233
Orf 24.15 11.41 11 878095 23 62610893
Vasogenic cerebral oedema 24.15 11.41 44 878062 852 62610064
Bronchopleural fistula 24.14 11.41 22 878084 203 62610713
Isosporiasis 24.13 11.41 12 878094 33 62610883
Hepatocellular injury 24.07 11.41 252 877854 27129 62583787
Atrioventricular block 24.07 11.41 43 878063 7604 62603312
Vascular device infection 24.03 11.41 40 878066 7272 62603644
Mouth ulceration 24.02 11.41 612 877494 32372 62578544
Anhedonia 23.91 11.41 75 878031 10899 62600017
Scedosporium infection 23.90 11.41 34 878072 529 62610387
Babesiosis 23.81 11.41 22 878084 207 62610709
Sputum culture positive 23.77 11.41 75 878031 2092 62608824
Pulmonary mass 23.74 11.41 442 877664 22154 62588762
Herpes simplex reactivation 23.67 11.41 34 878072 534 62610382
Fear of injection 23.63 11.41 175 877931 6989 62603927
Periostitis 23.63 11.41 27 878079 333 62610583
Disseminated sporotrichosis 23.61 11.41 10 878096 16 62610900
Respiratory tract inflammation 23.50 11.41 35 878071 569 62610347
Febrile neutropenia 23.49 11.41 1369 876737 117080 62493836
Cutaneous calcification 23.47 11.41 17 878089 109 62610807
Bronchial secretion retention 23.44 11.41 88 878018 2685 62608231
Haemolytic uraemic syndrome 23.33 11.41 82 878024 2421 62608495
Patent ductus arteriosus 23.30 11.41 15 878091 4235 62606681
Endocarditis bacterial 23.27 11.41 36 878070 606 62610310
Reversible airways obstruction 23.26 11.41 67 878039 1775 62609141
Frustration tolerance decreased 23.22 11.41 171 877935 6817 62604099
Pulse absent 23.20 11.41 24 878082 5350 62605566
Rhinitis 23.19 11.41 250 877856 11116 62599800
Renal injury 23.14 11.41 61 878045 9378 62601538
Dissociation 22.94 11.41 6 878100 2913 62608003
Rhonchi 22.82 11.41 83 878023 2493 62608423
Disseminated coccidioidomycosis 22.82 11.41 13 878093 51 62610865
Osteonecrosis 22.80 11.41 471 877635 24059 62586857
Hospitalisation 22.79 11.41 953 877153 84128 62526788
Disseminated cytomegaloviral infection 22.77 11.41 21 878085 197 62610719
Mucosal inflammation 22.76 11.41 485 877621 46443 62564473
Progressive multifocal leukoencephalopathy 22.73 11.41 277 877829 12694 62598222
Obsessive-compulsive disorder 22.71 11.41 14 878092 4046 62606870
Necrotising herpetic retinopathy 22.70 11.41 15 878091 81 62610835
Ageusia 22.67 11.41 105 878001 13623 62597293
Segmental diverticular colitis 22.67 11.41 19 878087 155 62610761
Tension headache 22.57 11.41 23 878083 5163 62605753
Anticipatory anxiety 22.52 11.41 52 878054 1199 62609717
Infection parasitic 22.49 11.41 26 878080 325 62610591
Metastatic squamous cell carcinoma 22.48 11.41 23 878083 248 62610668
Urinary tract candidiasis 22.46 11.41 34 878072 561 62610355
Embedded device 22.45 11.41 10 878096 3473 62607443
Complement factor C3 decreased 22.41 11.41 24 878082 274 62610642
Soft tissue sarcoma 22.34 11.41 18 878088 138 62610778
Perfume sensitivity 22.29 11.41 40 878066 765 62610151
Upper respiratory fungal infection 22.29 11.41 19 878087 159 62610757
Cutaneous leishmaniasis 22.28 11.41 15 878091 84 62610832
Impaired gastric emptying 22.24 11.41 71 878035 10261 62600655
B-cell lymphoma recurrent 22.22 11.41 28 878078 385 62610531
Human bocavirus infection 22.22 11.41 28 878078 385 62610531
Multiple fractures 22.20 11.41 199 877907 8419 62602497
Blood loss anaemia 22.19 11.41 58 878048 8943 62601973
Sleep terror 22.05 11.41 5 878101 2675 62608241
Elbow deformity 22.01 11.41 58 878048 1457 62609459
Pelvic pain 21.98 11.41 104 878002 13415 62597501
Maternal drugs affecting foetus 21.97 11.41 24 878082 5218 62605698
Immunosuppressant drug level decreased 21.90 11.41 44 878062 919 62609997
Encephalitis viral 21.87 11.41 63 878043 1669 62609247
Oral herpes 21.78 11.41 493 877613 25581 62585335
Rales 21.76 11.41 270 877836 12427 62598489
Drug level increased 21.76 11.41 205 877901 22531 62588385
Diabetic neuropathy 21.72 11.41 14 878092 3950 62606966
Taste disorder 21.68 11.41 106 878000 13556 62597360
Klebsiella infection 21.65 11.41 197 877909 8369 62602547
Cerebral haematoma 21.59 11.41 12 878094 3671 62607245
Body temperature decreased 21.54 11.41 398 877708 19921 62590995
Joint laxity 21.50 11.41 79 878027 2385 62608531
Kidney fibrosis 21.46 11.41 66 878040 1815 62609101
Implant site pain 21.22 11.41 4 878102 2436 62608480
Epstein-Barr virus test positive 21.21 11.41 34 878072 591 62610325
Urate nephropathy 21.11 11.41 16 878090 111 62610805
Pyomyositis 21.10 11.41 26 878080 349 62610567
Interstitial lung disease 21.07 11.41 1053 877053 60855 62550061
Glomerulosclerosis 21.07 11.41 27 878079 378 62610538
Chest X-ray abnormal 21.05 11.41 121 877985 4428 62606488
Blood calcium increased 21.02 11.41 63 878043 9287 62601629
Legionella infection 20.87 11.41 29 878077 441 62610475
Nerve injury 20.87 11.41 220 877886 9726 62601190
Enterobacter infection 20.79 11.41 73 878033 2154 62608762
Mycobacterium fortuitum infection 20.77 11.41 11 878095 36 62610880
Eye movement disorder 20.76 11.41 25 878081 5203 62605713
Pancreatitis acute 20.75 11.41 258 877848 26908 62584008
Back pain 20.72 11.41 3272 874834 260873 62350043
Cutaneous malacoplakia 20.68 11.41 9 878097 16 62610900
Pulmonary cavitation 20.60 11.41 40 878066 814 62610102
Herpes zoster cutaneous disseminated 20.54 11.41 19 878087 179 62610737
Product residue present 20.54 11.41 15 878091 3964 62606952
Unevaluable event 20.51 11.41 547 877559 50839 62560077
Exposure to SARS-CoV-2 20.50 11.41 62 878044 1689 62609227
Cerebral venous sinus thrombosis 20.49 11.41 67 878039 1905 62609011
Angina unstable 20.49 11.41 42 878064 7053 62603863
Premature labour 20.44 11.41 96 878010 12408 62598508
Aplastic anaemia 20.43 11.41 66 878040 9503 62601413
Blood thyroid stimulating hormone increased 20.43 11.41 43 878063 7151 62603765
Transfusion 20.34 11.41 125 877981 15092 62595824
Heparin-induced thrombocytopenia 20.31 11.41 20 878086 4562 62606354
Emphysematous pyelonephritis 20.29 11.41 22 878084 255 62610661
Blood potassium increased 20.24 11.41 159 877947 18150 62592766
Ureaplasma infection 20.18 11.41 34 878072 617 62610299
Extrasystoles 20.14 11.41 25 878081 5135 62605781
Pain in jaw 20.09 11.41 453 877653 43043 62567873
Skin fissures 20.08 11.41 85 878021 11303 62599613
Metabolic disorder 20.08 11.41 37 878069 6466 62604450
Substance-induced psychotic disorder 20.02 11.41 66 878040 1885 62609031
Cutaneous coccidioidomycosis 20.01 11.41 9 878097 18 62610898
Prosthesis user 19.99 11.41 13 878093 68 62610848
Sarcoma of skin 19.98 11.41 10 878096 28 62610888
Erythropoiesis abnormal 19.98 11.41 23 878083 286 62610630
Eosinophil count abnormal 19.97 11.41 32 878074 556 62610360
Dyspepsia 19.93 11.41 1183 876923 101013 62509903
Pedal pulse abnormal 19.93 11.41 18 878088 164 62610752
Application site rash 19.89 11.41 5 878101 2493 62608423
Mite allergy 19.84 11.41 34 878072 626 62610290
Limb mass 19.83 11.41 93 878013 3139 62607777
Central nervous system vasculitis 19.83 11.41 42 878064 912 62610004
Torus fracture 19.78 11.41 17 878089 144 62610772
Low density lipoprotein increased 19.78 11.41 36 878070 6321 62604595
Lung hernia 19.77 11.41 6 878100 0 62610916
Coagulopathy 19.76 11.41 185 877921 20359 62590557
Intestinal anastomosis 19.71 11.41 28 878078 435 62610481
Synovial cyst 19.70 11.41 226 877880 10207 62600709
Acute pulmonary histoplasmosis 19.63 11.41 16 878090 125 62610791
Chronic graft versus host disease in liver 19.58 11.41 22 878084 266 62610650
Smoke sensitivity 19.57 11.41 28 878078 438 62610478
Nystagmus 19.55 11.41 35 878071 6185 62604731
Hypertrophic osteoarthropathy 19.50 11.41 10 878096 30 62610886
Bronchial neoplasm 19.49 11.41 29 878077 471 62610445
Device related infection 19.47 11.41 218 877888 23174 62587742
Hypoaesthesia 19.44 11.41 2035 876071 166358 62444558
Product dispensing error 19.38 11.41 75 878031 10230 62600686
Dysuria 19.32 11.41 339 877767 33399 62577517
Abscess 19.27 11.41 331 877775 16337 62594579
Cervix disorder 19.21 11.41 32 878074 575 62610341
Incontinence 19.19 11.41 89 878017 11543 62599373
Quality of life decreased 19.08 11.41 196 877910 8607 62602309
Polydipsia 18.97 11.41 13 878093 3551 62607365
Hypersomnia 18.95 11.41 159 877947 17896 62593020
Stress cardiomyopathy 18.93 11.41 67 878039 9383 62601533
Pancreatic carcinoma 18.93 11.41 49 878057 7579 62603337
Myelosuppression 18.91 11.41 223 877883 23480 62587436
Activated partial thromboplastin time prolonged 18.91 11.41 42 878064 6851 62604065
Dialysis 18.90 11.41 77 878029 10350 62600566
Toothache 18.85 11.41 172 877934 19027 62591889
Ankle deformity 18.76 11.41 28 878078 456 62610460
Pneumocystis jirovecii infection 18.76 11.41 54 878052 1430 62609486
Bundle branch block right 18.70 11.41 25 878081 4973 62605943
Latent tuberculosis 18.69 11.41 79 878027 2548 62608368
Lymph node calcification 18.65 11.41 23 878083 309 62610607
Social avoidant behaviour 18.61 11.41 9 878097 2979 62607937
Infective tenosynovitis 18.60 11.41 23 878083 310 62610606
Chronic graft versus host disease oral 18.58 11.41 16 878090 136 62610780
Aspiration 18.52 11.41 82 878024 10769 62600147
Coronary artery stenosis 18.50 11.41 23 878083 4721 62606195
Pneumonia cytomegaloviral 18.50 11.41 70 878036 2144 62608772
Histoplasmosis cutaneous 18.46 11.41 8 878098 14 62610902
Arteriosclerosis 18.46 11.41 74 878032 9992 62600924
Anger 18.44 11.41 99 878007 12357 62598559
Skin plaque 18.39 11.41 186 877920 8134 62602782
Injection site mass 18.38 11.41 167 877939 18489 62592427
Erythema nodosum 18.37 11.41 123 877983 4752 62606164
Wound secretion 18.35 11.41 118 877988 4496 62606420
Hyperaesthesia 18.32 11.41 67 878039 9291 62601625
Renal tubular atrophy 18.30 11.41 36 878070 740 62610176
Red blood cell count decreased 18.30 11.41 425 877681 40220 62570696
Liver disorder 18.29 11.41 584 877522 53103 62557813
Myringotomy 18.29 11.41 9 878097 24 62610892
Meningitis coccidioides 18.29 11.41 9 878097 24 62610892
Carbohydrate antigen 125 increased 18.29 11.41 8 878098 2808 62608108
Colitis ischaemic 18.22 11.41 81 878025 10627 62600289
Eye abscess 18.22 11.41 16 878090 140 62610776
Oesophageal dilatation 18.19 11.41 25 878081 376 62610540
Pericardial effusion 18.19 11.41 299 877807 29759 62581157
Lymphocele 18.19 11.41 37 878069 780 62610136
General physical health deterioration 18.17 11.41 2474 875632 198928 62411988
Pruritus genital 18.11 11.41 7 878099 2647 62608269
Blood triglycerides increased 18.07 11.41 100 878006 12388 62598528
Extradural abscess 18.04 11.41 40 878066 897 62610019
Hepatitis B 18.04 11.41 102 878004 3710 62607206
Cancer pain 18.00 11.41 11 878095 3194 62607722
Cerebral toxoplasmosis 17.99 11.41 41 878065 937 62609979
Chorioretinitis 17.97 11.41 31 878075 574 62610342
Neurosarcoidosis 17.96 11.41 18 878088 189 62610727
Arthritis infective 17.94 11.41 152 877954 6326 62604590
Therapeutic product effect delayed 17.88 11.41 73 878033 2318 62608598
Grip strength decreased 17.87 11.41 419 877687 21868 62589048
Breast cancer stage IV 17.83 11.41 3 878103 1983 62608933
Perinephric abscess 17.81 11.41 18 878088 191 62610725
Folate deficiency 17.78 11.41 6 878100 2469 62608447
Granulocytopenia 17.76 11.41 32 878074 5640 62605276
Haemorrhage 17.75 11.41 677 877429 60345 62550571
Joint warmth 17.74 11.41 53 878053 1434 62609482
Cardiomyopathy acute 17.73 11.41 20 878086 243 62610673
Colitis microscopic 17.54 11.41 68 878038 9271 62601645
Oedematous kidney 17.51 11.41 14 878092 106 62610810
Amenorrhoea 17.48 11.41 74 878032 9840 62601076
Dacryocystitis 17.48 11.41 8 878098 17 62610899
Cardiogenic shock 17.45 11.41 161 877945 17771 62593145
Atrioventricular block second degree 17.44 11.41 17 878089 3897 62607019
Injection site induration 17.44 11.41 67 878039 9159 62601757
Hospice care 17.43 11.41 54 878052 7878 62603038
Eructation 17.43 11.41 58 878048 8275 62602641
Bradykinesia 17.41 11.41 28 878078 5160 62605756
Menstruation irregular 17.37 11.41 45 878061 6959 62603957
Erythema 17.30 11.41 2147 875959 173604 62437312
Escherichia infection 17.27 11.41 260 877846 12494 62598422
Bronchial haemorrhage 17.14 11.41 30 878076 562 62610354
Mycobacterium abscessus infection 17.13 11.41 32 878074 632 62610284
Haemorrhage subcutaneous 17.09 11.41 10 878096 2973 62607943
Mantle cell lymphoma recurrent 17.04 11.41 18 878088 202 62610714
Pulmonary arterial hypertension 17.03 11.41 215 877891 22362 62588554
Angiocentric lymphoma 17.02 11.41 31 878075 600 62610316
Drooling 17.01 11.41 17 878089 3851 62607065
Pyelonephritis fungal 16.92 11.41 15 878091 133 62610783
Alcohol use 16.87 11.41 4 878102 2075 62608841
Porokeratosis 16.75 11.41 15 878091 135 62610781
Systemic infection 16.74 11.41 24 878082 4636 62606280
Libido decreased 16.71 11.41 8 878098 2664 62608252
Blood chloride decreased 16.70 11.41 32 878074 5510 62605406
Lupus vasculitis 16.69 11.41 29 878077 540 62610376
Broncholithiasis 16.65 11.41 19 878087 234 62610682
Blood bicarbonate decreased 16.65 11.41 10 878096 2931 62607985
Salmonellosis 16.63 11.41 45 878061 1149 62609767
Infective scleritis 16.61 11.41 8 878098 20 62610896
Psychomotor skills impaired 16.57 11.41 6 878100 2362 62608554
Donor specific antibody present 16.56 11.41 16 878090 160 62610756
Systemic mycosis 16.55 11.41 45 878061 1152 62609764
Abortion induced 16.53 11.41 79 878027 10163 62600753
Metabolic alkalosis 16.51 11.41 11 878095 3050 62607866
Drug abuser 16.46 11.41 10 878096 2913 62608003
Campylobacter infection 16.46 11.41 42 878064 1034 62609882
Allergy to animal 16.40 11.41 46 878060 1200 62609716
Liver injury 16.40 11.41 1008 877098 59512 62551404
Bronchial obstruction 16.38 11.41 52 878054 1455 62609461
Suicidal behaviour 16.36 11.41 8 878098 2631 62608285
Hyperthermia 16.36 11.41 68 878038 9088 62601828
Pulmonary function test decreased 16.35 11.41 102 878004 3845 62607071
Mean cell haemoglobin concentration abnormal 16.35 11.41 14 878092 118 62610798
Nasal turbinate hypertrophy 16.33 11.41 34 878072 729 62610187
Chromaturia 16.31 11.41 150 877956 16567 62594349
Tooth infection 16.30 11.41 343 877763 17577 62593339
Headache 16.30 11.41 8232 869874 625009 61985907
Renal transplant 16.29 11.41 49 878057 1331 62609585
Nodular rash 16.28 11.41 17 878089 188 62610728
Oesophageal candidiasis 16.28 11.41 134 877972 5529 62605387
Cerebellar syndrome 16.21 11.41 15 878091 3524 62607392
Endometrial ablation 16.19 11.41 39 878067 925 62609991
Complement factor C4 decreased 16.15 11.41 20 878086 270 62610646
Blood thyroid stimulating hormone decreased 16.14 11.41 24 878082 4566 62606350
Tachypnoea 16.13 11.41 157 877949 17145 62593771
Respiratory rate increased 16.13 11.41 272 877834 13376 62597540
Tunnel vision 16.11 11.41 45 878061 1171 62609745
Oxygen saturation decreased 16.10 11.41 1429 876677 87156 62523760
Intestinal resection 16.07 11.41 80 878026 2768 62608148
Drug dose omission by device 16.02 11.41 26 878080 4775 62606141
Abdominal pain lower 16.01 11.41 254 877852 25424 62585492
Sciatica 15.96 11.41 603 877503 33721 62577195
Breast cancer recurrent 15.95 11.41 22 878084 4319 62606597
Night sweats 15.94 11.41 827 877279 47987 62562929
Breast pain 15.93 11.41 65 878041 8733 62602183
Bone disorder 15.92 11.41 397 877709 20929 62589987
Small for dates baby 15.91 11.41 17 878089 3734 62607182
Exposure during pregnancy 15.83 11.41 1896 876210 153651 62457265
Mania 15.81 11.41 103 878003 12264 62598652
Rhegmatogenous retinal detachment 15.80 11.41 13 878093 103 62610813
Angiosarcoma metastatic 15.75 11.41 11 878095 66 62610850
Asthmatic crisis 15.71 11.41 58 878048 1755 62609161
Hyperlipidaemia 15.66 11.41 184 877922 19387 62591529
Blood pressure inadequately controlled 15.66 11.41 28 878078 4950 62605966
Vitamin D deficiency 15.65 11.41 120 877986 13772 62597144
Accidental death 15.64 11.41 4 878102 1972 62608944
Drug level above therapeutic 15.64 11.41 117 877989 4688 62606228
Chronic disease 15.60 11.41 15 878091 149 62610767
Injection site nodule 15.59 11.41 18 878088 3817 62607099
Dysphoria 15.56 11.41 28 878078 4938 62605978
Enterocolitis 15.55 11.41 56 878050 7802 62603114
Loss of therapeutic response 15.50 11.41 30 878076 609 62610307
Chronic graft versus host disease in skin 15.47 11.41 33 878073 720 62610196
Blood cholesterol increased 15.46 11.41 1506 876600 92526 62518390
Tendon rupture 15.34 11.41 178 877928 8061 62602855
Hallucinations, mixed 15.34 11.41 27 878079 4802 62606114
Emotional distress 15.32 11.41 338 877768 32211 62578705
Anovulatory cycle 15.30 11.41 15 878091 153 62610763
Kaposi's sarcoma 15.30 11.41 15 878091 153 62610763
Soft tissue injury 15.29 11.41 54 878052 1598 62609318
Metastases to peritoneum 15.28 11.41 15 878091 3427 62607489
Cellulitis gangrenous 15.27 11.41 10 878096 53 62610863
Neck deformity 15.26 11.41 64 878042 2057 62608859
Hypoalbuminaemia 15.25 11.41 98 878008 11707 62599209
Abdominal wall infection 15.21 11.41 12 878094 89 62610827
Anal abscess 15.19 11.41 113 877993 4519 62606397
Rectal prolapse 15.19 11.41 61 878045 1922 62608994
Nephrolithiasis 15.10 11.41 718 877388 41266 62569650
Cholecystitis 14.99 11.41 138 877968 15239 62595677
Palindromic rheumatism 14.98 11.41 17 878089 208 62610708
Middle insomnia 14.95 11.41 252 877854 12391 62598525
Infusion site pain 14.93 11.41 155 877951 16714 62594202
Lacunar infarction 14.91 11.41 14 878092 3266 62607650
Disseminated intravascular coagulation 14.90 11.41 180 877926 18871 62592045
Myasthenia gravis crisis 14.90 11.41 26 878080 486 62610430
Bowel movement irregularity 14.84 11.41 124 877982 5140 62605776
Sensory loss 14.81 11.41 82 878024 10156 62600760
Basal cell carcinoma 14.80 11.41 499 877607 27492 62583424
Hypovolaemic shock 14.80 11.41 41 878065 6200 62604716
B-cell lymphoma stage IV 14.80 11.41 6 878100 8 62610908
Lung abscess 14.74 11.41 58 878048 1810 62609106
Bipolar I disorder 14.74 11.41 4 878102 1895 62609021
B-cell lymphoma 14.70 11.41 87 878019 3218 62607698
Kounis syndrome 14.70 11.41 3 878103 1727 62609189
Hypophosphataemia 14.69 11.41 95 878011 11331 62599585
Asthma-chronic obstructive pulmonary disease overlap syndrome 14.68 11.41 62 878044 1999 62608917
Graft versus host disease in lung 14.67 11.41 22 878084 360 62610556
Metastases to spine 14.61 11.41 14 878092 3235 62607681
Bronchitis 14.58 11.41 1957 876149 122978 62487938
Application site pain 14.58 11.41 22 878084 4160 62606756
Human herpesvirus 6 infection 14.58 11.41 80 878026 2877 62608039
Cold sweat 14.57 11.41 102 878004 11945 62598971
Needle issue 14.52 11.41 84 878022 10292 62600624
Diabetic retinopathy 14.51 11.41 7 878099 2320 62608596
Hepatic cyst 14.47 11.41 31 878075 5123 62605793
Retching 14.47 11.41 131 877975 14514 62596402
Haemodialysis 14.44 11.41 69 878037 8878 62602038
Cytomegalovirus chorioretinitis 14.42 11.41 56 878050 1737 62609179
Therapy change 14.38 11.41 40 878066 6041 62604875
Forced vital capacity decreased 14.36 11.41 40 878066 1039 62609877
Cholecystitis acute 14.35 11.41 62 878044 8198 62602718
Abscess intestinal 14.30 11.41 52 878054 1562 62609354
Osteomyelitis bacterial 14.27 11.41 16 878090 193 62610723
Hypothyroidism 14.22 11.41 465 877641 42167 62568749
Carpal tunnel syndrome 14.22 11.41 383 877723 20434 62590482
Diabetes mellitus inadequate control 14.21 11.41 137 877969 14989 62595927
Hypochloraemia 14.21 11.41 5 878101 2004 62608912
Cryptococcal meningoencephalitis 14.21 11.41 12 878094 99 62610817
Body temperature fluctuation 14.21 11.41 66 878040 2219 62608697
Diffuse alveolar damage 14.19 11.41 36 878070 883 62610033
Conjunctival irritation 14.17 11.41 5 878101 3 62610913
Acute coronary syndrome 14.16 11.41 82 878024 10044 62600872
Pancreatitis haemorrhagic 14.14 11.41 26 878080 507 62610409
Salpingo-oophorectomy unilateral 14.12 11.41 35 878071 846 62610070
Alcohol abuse 14.09 11.41 6 878100 2140 62608776
Abdominal abscess 14.05 11.41 109 877997 4417 62606499
Inadequate analgesia 14.05 11.41 12 878094 2931 62607985
Occupational asthma 14.04 11.41 14 878092 146 62610770
Pulmonary aplasia 14.02 11.41 6 878100 10 62610906
Systemic bacterial infection 14.02 11.41 6 878100 10 62610906
Genital herpes simplex 14.01 11.41 19 878087 282 62610634
On and off phenomenon 13.99 11.41 4 878102 1831 62609085
International normalised ratio abnormal 13.99 11.41 15 878091 3289 62607627
Jaundice cholestatic 13.97 11.41 53 878053 7271 62603645
Hypoaldosteronism 13.95 11.41 15 878091 172 62610744
Nervousness 13.92 11.41 324 877782 30655 62580261
Drug dependence 13.86 11.41 440 877666 24043 62586873
Antibody test positive 13.86 11.41 74 878032 2633 62608283
Ear congestion 13.84 11.41 75 878031 2684 62608232
Nodular regenerative hyperplasia 13.83 11.41 25 878081 481 62610435
Underdose 13.83 11.41 282 877824 27174 62583742
Product storage error 13.82 11.41 136 877970 14820 62596096
Complications of bone marrow transplant 13.81 11.41 24 878082 447 62610469
Colon cancer 13.81 11.41 80 878026 9798 62601118
Alcoholism 13.79 11.41 4 878102 1814 62609102
Dactylitis 13.78 11.41 72 878034 2540 62608376
Foetal death 13.76 11.41 92 878014 10888 62600028
Atypical haemolytic uraemic syndrome 13.73 11.41 31 878075 704 62610212
Viral mutation identified 13.70 11.41 4 878102 1806 62609110
Encephalitis brain stem 13.69 11.41 13 878093 127 62610789
Joint dislocation reduction 13.67 11.41 6 878100 11 62610905
Herpes virus infection 13.65 11.41 127 877979 5429 62605487
Large intestinal ulcer 13.65 11.41 88 878018 3356 62607560
Calcium ionised decreased 13.62 11.41 19 878087 290 62610626
Abscess limb 13.60 11.41 115 877991 4783 62606133
Renal cancer 13.59 11.41 36 878070 5526 62605390
Acanthoma 13.59 11.41 5 878101 4 62610912
Extranodal marginal zone B-cell lymphoma (MALT type) stage IV 13.59 11.41 5 878101 4 62610912
Papillary renal cell carcinoma 13.59 11.41 5 878101 4 62610912
Infusion site erythema 13.58 11.41 100 878006 11579 62599337
Bone density abnormal 13.57 11.41 87 878019 3311 62607605
Immunoglobulins decreased 13.52 11.41 44 878062 1248 62609668
Apathy 13.52 11.41 69 878037 8725 62602191
Dermatitis bullous 13.51 11.41 66 878040 8442 62602474
Urine ketone body present 13.49 11.41 9 878097 2494 62608422
Pneumonia legionella 13.44 11.41 52 878054 1610 62609306
Medical device site joint infection 13.38 11.41 18 878088 265 62610651
Subdural haemorrhage 13.38 11.41 14 878092 3104 62607812
Post transplant distal limb syndrome 13.37 11.41 17 878089 236 62610680
Dysaesthesia 13.37 11.41 26 878080 4452 62606464
Pulseless electrical activity 13.35 11.41 56 878050 7465 62603451
Pseudomembranous colitis 13.32 11.41 14 878092 3098 62607818
Anogenital warts 13.31 11.41 25 878081 496 62610420
Sinus node dysfunction 13.30 11.41 28 878078 4657 62606259
Acarodermatitis 13.30 11.41 39 878067 1044 62609872
Superior sagittal sinus thrombosis 13.29 11.41 32 878074 759 62610157
Thrombosis 13.27 11.41 746 877360 64009 62546907
Arteriosclerosis coronary artery 13.27 11.41 65 878041 8308 62602608
Dermatitis acneiform 13.25 11.41 31 878075 4965 62605951
Post procedural discharge 13.24 11.41 25 878081 498 62610418
Wrong patient received product 13.22 11.41 7 878099 2200 62608716
Hepatitis acute 13.21 11.41 73 878033 9047 62601869
Incorrect dose administered by device 13.19 11.41 25 878081 4323 62606593
Mitral valve incompetence 13.18 11.41 191 877915 19403 62591513
Bordetella infection 13.18 11.41 4 878102 0 62610916
Herpes zoster meningoradiculitis 13.18 11.41 4 878102 0 62610916
Paracoccidioides infection 13.18 11.41 4 878102 0 62610916
Chronic rhinosinusitis with nasal polyps 13.18 11.41 4 878102 0 62610916
T-cell lymphoma 13.18 11.41 29 878077 647 62610269
Rhodococcus infection 13.14 11.41 12 878094 111 62610805
Candida pneumonia 13.13 11.41 14 878092 159 62610757
Hyperbilirubinaemia 13.10 11.41 97 878009 11217 62599699
Blood magnesium decreased 13.06 11.41 118 877988 13080 62597836
Perinephric collection 13.06 11.41 12 878094 112 62610804
Retinal haemorrhage 13.05 11.41 31 878075 4938 62605978
Adrenal suppression 13.04 11.41 35 878071 889 62610027
Adjustment disorder with depressed mood 13.04 11.41 206 877900 9998 62600918
Neck mass 13.04 11.41 90 878016 3513 62607403
Leiomyosarcoma metastatic 13.03 11.41 6 878100 13 62610903
Intestinal ischaemia 13.01 11.41 56 878050 7412 62603504
Ophthalmic herpes zoster 12.98 11.41 60 878046 2013 62608903
Chronic graft versus host disease in eye 12.98 11.41 12 878094 113 62610803
Human chorionic gonadotropin increased 12.96 11.41 3 878103 1582 62609334
Nodal rhythm 12.92 11.41 4 878102 1739 62609177
Bunion operation 12.92 11.41 44 878062 1278 62609638
Enuresis 12.89 11.41 10 878096 2563 62608353
Catheter site pain 12.87 11.41 29 878077 4706 62606210
Faecal volume decreased 12.86 11.41 14 878092 163 62610753
Cardiovascular disorder 12.86 11.41 103 878003 11709 62599207
Ectopic pregnancy 12.83 11.41 10 878096 2557 62608359
Hepatotoxicity 12.80 11.41 631 877475 36410 62574506
Cryopyrin associated periodic syndrome 12.79 11.41 20 878086 340 62610576
Insomnia 12.78 11.41 2706 875400 212546 62398370
Colectomy total 12.73 11.41 14 878092 165 62610751
Kidney infection 12.73 11.41 415 877691 22761 62588155
Ovarian cyst 12.72 11.41 150 877956 15795 62595121
Language disorder 12.72 11.41 7 878099 2153 62608763
Peptic ulcer haemorrhage 12.68 11.41 38 878068 1030 62609886
Haematocrit decreased 12.68 11.41 431 877675 38909 62572007
Oesophageal stenosis 12.67 11.41 83 878023 3183 62607733
Chronic spontaneous urticaria 12.65 11.41 40 878066 1117 62609799
Paranoia 12.64 11.41 102 878004 11577 62599339
Catheter site erythema 12.62 11.41 25 878081 4251 62606665
Cytomegalovirus oesophagitis 12.60 11.41 17 878089 251 62610665
Thyroid neoplasm 12.60 11.41 97 878009 3922 62606994
Juvenile idiopathic arthritis 12.58 11.41 84 878022 3242 62607674
Alveolar proteinosis 12.58 11.41 20 878086 345 62610571
Ventricular arrhythmia 12.53 11.41 21 878085 3807 62607109
Sepsis 12.52 11.41 1892 876214 151231 62459685
Anuria 12.51 11.41 112 877994 12439 62598477
Disseminated large cell lymphoma 12.51 11.41 9 878097 57 62610859
Pre-existing condition improved 12.49 11.41 65 878041 8179 62602737
Functional gastrointestinal disorder 12.48 11.41 25 878081 4234 62606682
Acute hepatitis C 12.48 11.41 10 878096 76 62610840
Blood urea decreased 12.47 11.41 9 878097 2393 62608523
Laryngeal stenosis 12.46 11.41 38 878068 1040 62609876
Perihepatic abscess 12.46 11.41 6 878100 15 62610901
CD8 lymphocytes increased 12.46 11.41 6 878100 15 62610901
Q fever 12.44 11.41 13 878093 144 62610772
Electrocardiogram ST segment elevation 12.43 11.41 22 878084 3905 62607011
Limb injury 12.43 11.41 450 877656 25027 62585889
Metastasis 12.43 11.41 34 878072 5163 62605753
Muscle spasticity 12.42 11.41 392 877714 21402 62589514
Antinuclear antibody positive 12.40 11.41 167 877939 7832 62603084
Urticaria thermal 12.40 11.41 22 878084 417 62610499
Pneumatosis intestinalis 12.38 11.41 66 878040 2347 62608569
Cardiac failure acute 12.33 11.41 79 878027 9444 62601472
Genitourinary tract infection 12.33 11.41 16 878090 227 62610689
Tachyarrhythmia 12.30 11.41 27 878079 4423 62606493
Throat clearing 12.30 11.41 66 878040 2353 62608563
Leukocytosis 12.29 11.41 269 877837 25666 62585250
Acute lymphocytic leukaemia recurrent 12.29 11.41 63 878043 2206 62608710
Primary immunodeficiency syndrome 12.28 11.41 8 878098 42 62610874
Periorbital oedema 12.28 11.41 39 878067 5645 62605271
Mastitis bacterial 12.27 11.41 9 878097 59 62610857
Expired product administered 12.27 11.41 44 878062 6137 62604779
Abnormal loss of weight 12.26 11.41 40 878066 5742 62605174
Antineutrophil cytoplasmic antibody positive 12.25 11.41 27 878079 603 62610313
Electrocardiogram ST segment depression 12.25 11.41 13 878093 2864 62608052
Affect lability 12.25 11.41 97 878009 11054 62599862
Device use issue 12.22 11.41 11 878095 2619 62608297
Sinusitis fungal 12.22 11.41 54 878052 1777 62609139
Meningitis histoplasma 12.19 11.41 5 878101 7 62610909
Hypersensitivity myocarditis 12.19 11.41 15 878091 201 62610715
Oligohydramnios 12.18 11.41 46 878060 6320 62604596
Viraemia 12.17 11.41 43 878063 1273 62609643
Cogwheel rigidity 12.17 11.41 6 878100 1964 62608952
Fryns syndrome 12.15 11.41 9 878097 60 62610856
Coronary artery bypass 12.14 11.41 9 878097 2360 62608556
Epstein Barr virus positive mucocutaneous ulcer 12.11 11.41 22 878084 425 62610491
Anaesthetic complication 12.06 11.41 6 878100 1954 62608962
Cardiac failure chronic 12.05 11.41 27 878079 4391 62606525
Adrenocortical insufficiency acute 12.03 11.41 51 878055 1647 62609269
Factor XIII deficiency 11.98 11.41 10 878096 81 62610835
Inflammatory bowel disease 11.96 11.41 95 878011 3878 62607038
Maternal exposure during delivery 11.95 11.41 3 878103 1497 62609419
Pancreas transplant 11.94 11.41 6 878100 17 62610899
Acute hepatitis B 11.86 11.41 19 878087 330 62610586
Paraesthesia oral 11.83 11.41 191 877915 19065 62591851
Agranulocytosis 11.83 11.41 261 877845 24873 62586043
Intervertebral disc compression 11.82 11.41 40 878066 1158 62609758
Avian influenza 11.81 11.41 9 878097 63 62610853
Birdshot chorioretinopathy 11.81 11.41 9 878097 63 62610853
Acute respiratory distress syndrome 11.81 11.41 417 877689 23117 62587799
Ileal stenosis 11.79 11.41 51 878055 1662 62609254
Selective eating disorder 11.79 11.41 7 878099 2065 62608851
Keratitis fungal 11.77 11.41 13 878093 154 62610762
Increased bronchial secretion 11.72 11.41 52 878054 1714 62609202
Growth retardation 11.71 11.41 43 878063 1298 62609618
Skin burning sensation 11.68 11.41 116 877990 12618 62598298
Incorrect dosage administered 11.68 11.41 58 878048 2005 62608911
Pseudopolyp 11.65 11.41 17 878089 271 62610645
Herpes dermatitis 11.65 11.41 7 878099 31 62610885
Haemorrhagic stroke 11.65 11.41 41 878065 5751 62605165
Gastroenteritis norovirus 11.61 11.41 58 878048 2010 62608906
Cyst 11.60 11.41 266 877840 13833 62597083
Eosinophilic pneumonia chronic 11.58 11.41 14 878092 184 62610732
Cavernous sinus thrombosis 11.58 11.41 13 878093 157 62610759
Genital lesion 11.53 11.41 16 878090 243 62610673
Hepatitis E 11.53 11.41 45 878061 1399 62609517
Faecal calprotectin abnormal 11.52 11.41 10 878096 86 62610830
Neutrophilia 11.48 11.41 102 878004 4304 62606612
Bladder cancer 11.46 11.41 39 878067 5527 62605389
Herpes simplex encephalitis 11.46 11.41 19 878087 340 62610576
Protothecosis 11.45 11.41 5 878101 9 62610907
Pleomorphism 11.45 11.41 5 878101 9 62610907
Hepatitis toxic 11.45 11.41 17 878089 3236 62607680

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 895.13 11.68 8075 397230 411449 34140177
Colitis ulcerative 856.61 11.68 1007 404298 15513 34536113
Drug abuse 841.42 11.68 86 405219 99010 34452616
Drug ineffective 783.44 11.68 8401 396904 448350 34103276
Asthma 745.37 11.68 1575 403730 41081 34510545
Completed suicide 683.40 11.68 151 405154 98017 34453609
Condition aggravated 550.13 11.68 3962 401343 188234 34363392
Wheezing 526.88 11.68 1350 403955 40052 34511574
Therapeutic product effect incomplete 490.32 11.68 1493 403812 49048 34502578
Nocardiosis 489.06 11.68 389 404916 3562 34548064
Transplant rejection 444.78 11.68 573 404732 9738 34541888
Rheumatoid arthritis 429.98 11.68 1191 404114 37047 34514579
Intentional product use issue 424.57 11.68 1591 403714 58225 34493401
Sleep disorder due to a general medical condition 419.76 11.68 402 404903 4819 34546807
Product use in unapproved indication 406.39 11.68 2540 402765 114959 34436667
Post transplant lymphoproliferative disorder 401.54 11.68 435 404870 6093 34545533
Overdose 395.68 11.68 287 405018 90772 34460854
Polyomavirus-associated nephropathy 395.53 11.68 340 404965 3504 34548122
Toxicity to various agents 379.76 11.68 1131 404174 199231 34352395
Intentional overdose 360.08 11.68 42 405263 43632 34507994
Loss of personal independence in daily activities 355.91 11.68 1016 404289 32163 34519463
Death 351.08 11.68 2944 402361 395105 34156521
Pneumocystis jirovecii pneumonia 324.82 11.68 711 404594 18999 34532627
Aspergillus infection 317.95 11.68 536 404769 11718 34539908
Obstructive airways disorder 313.14 11.68 608 404697 14886 34536740
Full blood count abnormal 307.16 11.68 673 404632 17995 34533631
Cytomegalovirus infection 303.66 11.68 824 404481 25311 34526315
Bradycardia 300.76 11.68 259 405046 75159 34476467
Kidney transplant rejection 297.62 11.68 400 404905 7097 34544529
Frequent bowel movements 294.89 11.68 531 404774 12256 34539370
Somnolence 270.85 11.68 550 404755 110566 34441060
Fall 258.97 11.68 1341 403964 201544 34350082
Strongyloidiasis 245.41 11.68 223 405082 2488 34549138
Disease recurrence 240.15 11.68 668 404637 20822 34530804
Hypotension 235.97 11.68 1553 403752 220096 34331530
Productive cough 235.10 11.68 965 404340 36848 34514778
Blood pressure fluctuation 227.27 11.68 727 404578 24522 34527104
Inappropriate schedule of product administration 224.69 11.68 1362 403943 60934 34490692
Histoplasmosis disseminated 214.73 11.68 155 405150 1208 34550418
Dizziness 209.59 11.68 1578 403727 216943 34334683
Cryptococcosis 207.34 11.68 193 405112 2226 34549400
Confusional state 204.64 11.68 917 404388 143243 34408383
Arthralgia 203.12 11.68 2929 402376 167112 34384514
Rhabdomyolysis 202.94 11.68 297 405008 67866 34483760
Bronchiectasis 199.74 11.68 386 404919 9415 34542211
Hypoglycaemia 199.72 11.68 203 405102 54437 34497189
Suicide attempt 198.00 11.68 103 405202 39013 34512613
Drug level below therapeutic 196.56 11.68 282 405023 5333 34546293
Mucormycosis 195.78 11.68 290 405015 5652 34545974
Seizure 193.93 11.68 598 404707 104259 34447367
Phaeohyphomycosis 192.99 11.68 122 405183 742 34550884
Treatment failure 192.54 11.68 1058 404247 45639 34505987
Loss of consciousness 190.65 11.68 422 404883 82245 34469381
Diffuse large B-cell lymphoma recurrent 184.50 11.68 207 405098 3021 34548605
Intentional product misuse 183.78 11.68 155 405150 45456 34506170
Weight increased 177.01 11.68 1752 403553 91281 34460345
Electrocardiogram QT prolonged 175.27 11.68 131 405174 40821 34510805
Myocardial infarction 174.95 11.68 765 404540 120320 34431306
Agitation 171.93 11.68 249 405056 57150 34494476
Aggression 171.50 11.68 121 405184 38843 34512783
Blood creatine phosphokinase increased 166.97 11.68 164 405141 44693 34506933
Coma 166.59 11.68 170 405135 45508 34506118
Cytomegalovirus viraemia 165.54 11.68 304 405001 7126 34544500
Rebound effect 165.39 11.68 197 405108 3077 34548549
Cardio-respiratory arrest 165.34 11.68 240 405065 55033 34496593
Malacoplakia 163.68 11.68 88 405217 374 34551252
Histoplasmosis 159.70 11.68 136 405169 1382 34550244
Disease progression 156.81 11.68 1929 403376 106148 34445478
Joint swelling 155.02 11.68 1207 404098 58683 34492943
Complications of transplanted kidney 153.37 11.68 226 405079 4383 34547243
Hyponatraemia 152.56 11.68 472 404833 82219 34469407
Hallucination 151.69 11.68 226 405079 51272 34500354
COVID-19 150.68 11.68 1467 403838 76083 34475543
Acute kidney injury 149.08 11.68 2564 402741 302424 34249202
Cough 148.94 11.68 2507 402798 147633 34403993
Transplant dysfunction 148.21 11.68 168 405137 2481 34549145
Blastomycosis 146.76 11.68 82 405223 382 34551244
Drug level decreased 146.62 11.68 298 405007 7548 34544078
Epstein-Barr virus infection 146.46 11.68 293 405012 7335 34544291
BK virus infection 146.21 11.68 249 405056 5489 34546137
Progressive multifocal leukoencephalopathy 144.98 11.68 338 404967 9426 34542200
Depressed level of consciousness 144.57 11.68 170 405135 42671 34508955
Constipation 144.40 11.68 962 404343 136020 34415606
Nausea 142.84 11.68 2933 402372 336975 34214651
Sputum discoloured 142.78 11.68 294 405011 7518 34544108
Hepatitis B reactivation 141.48 11.68 199 405106 3692 34547934
Vomiting 140.34 11.68 2024 403281 245597 34306029
Therapy partial responder 139.65 11.68 330 404975 9286 34542340
Hepatic function abnormal 139.30 11.68 186 405119 44177 34507449
General physical health deterioration 138.13 11.68 895 404410 127374 34424252
Syncope 138.07 11.68 568 404737 90883 34460743
Neuroleptic malignant syndrome 136.56 11.68 22 405283 17912 34533714
Sedation 135.01 11.68 38 405267 20968 34530658
Respiratory depression 132.94 11.68 16 405289 16229 34535397
Drug interaction 130.75 11.68 1839 403466 224107 34327519
Osteoporosis 129.11 11.68 381 404924 12287 34539339
Suicidal ideation 128.17 11.68 168 405137 40220 34511406
Serotonin syndrome 126.38 11.68 37 405268 19896 34531730
Weight decreased 125.23 11.68 2798 402507 173503 34378123
Focal segmental glomerulosclerosis 122.89 11.68 134 405171 1891 34549735
Bronchopulmonary aspergillosis 122.84 11.68 412 404893 14247 34537379
Angioedema 122.19 11.68 152 405153 37222 34514404
Faecal calprotectin increased 121.85 11.68 149 405156 2395 34549231
Restlessness 120.45 11.68 73 405232 25409 34526217
Brain abscess 119.88 11.68 164 405141 2961 34548665
Therapeutic response shortened 119.59 11.68 265 405040 7139 34544487
Nasal congestion 119.31 11.68 557 404748 22500 34529126
Forced expiratory volume decreased 118.23 11.68 165 405140 3038 34548588
Therapeutic product effect decreased 116.67 11.68 746 404559 33997 34517629
Human herpesvirus 8 infection 116.41 11.68 94 405211 881 34550745
Cardiac arrest 115.55 11.68 648 404657 95511 34456115
Cytomegalovirus colitis 114.27 11.68 151 405154 2633 34548993
Extrapyramidal disorder 112.32 11.68 10 405295 12870 34538756
Chronic allograft nephropathy 109.11 11.68 101 405204 1156 34550470
International normalised ratio increased 108.73 11.68 242 405063 47085 34504541
West Nile viral infection 104.31 11.68 79 405226 668 34550958
Delirium 103.49 11.68 222 405083 43769 34507857
Steroid dependence 101.99 11.68 106 405199 1411 34550215
Impaired quality of life 101.70 11.68 215 405090 5603 34546023
Pseudomonas infection 101.10 11.68 345 404960 12037 34539589
Cardiac failure 98.52 11.68 636 404669 90612 34461014
Cerebral infarction 98.04 11.68 104 405201 27351 34524275
Abnormal behaviour 97.96 11.68 87 405218 24882 34526744
Respiratory arrest 97.07 11.68 109 405196 27934 34523692
Mycobacterium avium complex infection 96.66 11.68 132 405173 2379 34549247
Clostridium difficile infection 96.66 11.68 455 404850 18443 34533183
Heart rate decreased 96.54 11.68 665 404640 31080 34520546
Renal transplant failure 96.26 11.68 89 405216 1017 34550609
Pulmonary nocardiosis 94.81 11.68 81 405224 827 34550799
Acute respiratory distress syndrome 94.33 11.68 569 404736 25400 34526226
Immunosuppressant drug level increased 92.53 11.68 212 405093 5843 34545783
Rash 92.16 11.68 1926 403379 220826 34330800
Therapeutic reaction time decreased 91.73 11.68 92 405213 1171 34550455
Posterior reversible encephalopathy syndrome 90.81 11.68 288 405017 9666 34541960
Haematochezia 90.68 11.68 881 404424 45653 34505973
Colitis 90.66 11.68 748 404557 37002 34514624
Musculoskeletal stiffness 90.59 11.68 883 404422 45797 34505829
Defaecation urgency 90.58 11.68 130 405175 2459 34549167
Epistaxis 90.27 11.68 358 404947 57893 34493733
Intentional self-injury 90.21 11.68 24 405281 13747 34537879
Mycobacterial infection 90.18 11.68 124 405181 2250 34549376
Varicella zoster virus infection 90.12 11.68 108 405197 1698 34549928
Altered state of consciousness 89.53 11.68 80 405225 22813 34528813
Tachycardia 88.92 11.68 596 404709 84176 34467450
Pulmonary mass 88.48 11.68 338 404967 12474 34539152
Cerebrovascular accident 88.10 11.68 598 404707 84213 34467413
White blood cell count decreased 88.09 11.68 696 404609 94749 34456877
Alternaria infection 87.76 11.68 56 405249 347 34551279
Pneumonia aspiration 86.96 11.68 226 405079 41677 34509949
Circulatory collapse 86.58 11.68 70 405235 20968 34530658
Product use issue 86.33 11.68 1116 404189 62100 34489526
Lactic acidosis 85.57 11.68 171 405134 34601 34517025
Escherichia infection 85.00 11.68 249 405056 7996 34543630
Fungal infection 84.69 11.68 388 404917 15547 34536079
Dehydration 84.14 11.68 1033 404272 128936 34422690
Adenovirus infection 83.60 11.68 187 405118 5070 34546556
Disorientation 82.71 11.68 162 405143 33026 34518600
Steroid diabetes 82.40 11.68 114 405191 2081 34549545
Platelet count decreased 82.30 11.68 939 404366 118778 34432848
Dysarthria 82.25 11.68 175 405130 34607 34517019
Septic shock 82.24 11.68 1229 404076 70605 34481021
Rhodococcus infection 81.20 11.68 43 405262 176 34551450
Haematotoxicity 81.18 11.68 244 405061 7950 34543676
Lymphadenopathy 81.15 11.68 587 404718 27876 34523750
Ventricular fibrillation 80.79 11.68 88 405217 22866 34528760
Disturbance in attention 80.20 11.68 110 405195 25835 34525791
Cognitive disorder 79.64 11.68 131 405174 28562 34523064
JC virus infection 78.91 11.68 112 405193 2096 34549530
Osteonecrosis 78.72 11.68 362 404943 14528 34537098
Graft loss 78.68 11.68 72 405233 811 34550815
Sinus pain 78.26 11.68 66 405239 661 34550965
Palmar-plantar erythrodysaesthesia syndrome 78.15 11.68 49 405256 16746 34534880
Schizophrenia 77.58 11.68 6 405299 8660 34542966
Aspartate aminotransferase increased 77.53 11.68 464 404841 67319 34484307
Lung transplant rejection 77.34 11.68 68 405237 724 34550902
Parvovirus B19 infection 76.74 11.68 70 405235 785 34550841
Kidney fibrosis 76.67 11.68 111 405194 2117 34549509
Nasal polyps 76.55 11.68 118 405187 2385 34549241
Miosis 76.54 11.68 10 405295 9525 34542101
Blood immunoglobulin E increased 76.42 11.68 119 405186 2427 34549199
Acute myocardial infarction 75.92 11.68 342 404963 53377 34498249
Sensitivity to weather change 75.88 11.68 94 405211 1532 34550094
Meningitis cryptococcal 75.87 11.68 115 405190 2289 34549337
Substance abuse 75.45 11.68 3 405302 7638 34543988
Orthostatic hypotension 75.09 11.68 115 405190 25804 34525822
Herpes zoster 74.92 11.68 667 404638 33732 34517894
Pulmonary function test decreased 73.62 11.68 172 405133 4803 34546823
Dyskinesia 73.41 11.68 91 405214 22322 34529304
Product prescribing error 73.11 11.68 95 405210 22832 34528794
Coronary artery disease 72.87 11.68 300 405005 48005 34503621
Pneumocystis jirovecii infection 72.64 11.68 96 405209 1674 34549952
Immunosuppression 72.43 11.68 198 405107 6106 34545520
Mucous stools 72.30 11.68 96 405209 1682 34549944
Infection 72.20 11.68 1467 403838 89448 34462178
Infection reactivation 72.17 11.68 88 405217 1410 34550216
Cushingoid 72.10 11.68 120 405185 2594 34549032
Legionella infection 72.02 11.68 54 405251 449 34551177
Arthropathy 71.64 11.68 546 404759 26361 34525265
Vaccination failure 71.58 11.68 77 405228 1069 34550557
Arthritis 71.49 11.68 614 404691 30732 34520894
Dust allergy 71.39 11.68 69 405236 837 34550789
Epstein-Barr viraemia 71.36 11.68 82 405223 1230 34550396
Memory impairment 71.13 11.68 260 405045 43058 34508568
Asthma-chronic obstructive pulmonary disease overlap syndrome 70.95 11.68 81 405224 1206 34550420
Pneumonia cytomegaloviral 70.63 11.68 127 405178 2927 34548699
Erectile dysfunction 70.57 11.68 81 405224 20556 34531070
Philadelphia positive chronic myeloid leukaemia 69.64 11.68 33 405272 100 34551526
Liver disorder 69.20 11.68 177 405128 32820 34518806
Wrong technique in product usage process 68.77 11.68 202 405103 35784 34515842
Poisoning 68.36 11.68 28 405277 12198 34539428
Unresponsive to stimuli 68.33 11.68 135 405170 27434 34524192
Labelled drug-drug interaction medication error 67.58 11.68 45 405260 14894 34536732
Ureaplasma infection 67.31 11.68 46 405259 325 34551301
Human ehrlichiosis 67.20 11.68 46 405259 326 34551300
Cryptosporidiosis infection 66.98 11.68 51 405254 435 34551191
Eosinophil count abnormal 66.81 11.68 43 405262 271 34551355
Osteopenia 66.74 11.68 163 405142 4686 34546940
Decreased appetite 66.32 11.68 1447 403858 164945 34386681
Hyperkalaemia 65.87 11.68 502 404803 68887 34482739
Haematemesis 65.87 11.68 139 405166 27572 34524054
Hepatitis B 65.85 11.68 185 405120 5798 34545828
Drug withdrawal syndrome 65.52 11.68 80 405225 19754 34531872
Irritability 65.52 11.68 116 405189 24574 34527052
Drug reaction with eosinophilia and systemic symptoms 65.51 11.68 182 405123 32830 34518796
Fungal skin infection 65.39 11.68 113 405192 2521 34549105
Bronchial wall thickening 65.32 11.68 80 405225 1288 34550338
Diffuse large B-cell lymphoma 65.20 11.68 211 405094 7159 34544467
Cerebral haemorrhage 64.68 11.68 199 405106 34738 34516888
Blood pressure increased 64.55 11.68 1405 403900 86697 34464929
Eosinophilic granulomatosis with polyangiitis 64.06 11.68 96 405209 1891 34549735
Paranoia 63.74 11.68 30 405275 12038 34539588
Mycobacterium haemophilum infection 63.64 11.68 29 405276 78 34551548
Scedosporium infection 63.60 11.68 64 405241 818 34550808
Renal tubular atrophy 63.32 11.68 73 405232 1099 34550527
Humoral immune defect 63.32 11.68 35 405270 159 34551467
Encephalitis viral 62.99 11.68 74 405231 1138 34550488
Graft versus host disease in lung 62.83 11.68 53 405252 531 34551095
Obstruction 62.79 11.68 113 405192 2606 34549020
Prostatic specific antigen increased 62.75 11.68 336 404969 14344 34537282
Lymphopenia 62.59 11.68 363 404942 15972 34535654
Lymphoma 62.41 11.68 299 405006 12208 34539418
Klebsiella infection 62.18 11.68 229 405076 8302 34543324
Hyperhidrosis 62.17 11.68 569 404736 75123 34476503
Febrile neutropenia 61.89 11.68 2049 403256 134800 34416826
Bacillary angiomatosis 61.85 11.68 31 405274 110 34551516
Impaired work ability 61.84 11.68 199 405106 6731 34544895
Stevens-Johnson syndrome 61.76 11.68 75 405230 18564 34533062
American trypanosomiasis 61.72 11.68 38 405267 219 34551407
Candida infection 61.08 11.68 383 404922 17332 34534294
Heart rate irregular 61.04 11.68 352 404953 15455 34536171
Depression 60.83 11.68 777 404528 96321 34455305
Alanine aminotransferase increased 60.67 11.68 621 404684 80194 34471432
Hepatitis E 60.54 11.68 96 405209 1990 34549636
Ascites 60.25 11.68 306 404999 46265 34505361
Disseminated blastomycosis 59.88 11.68 32 405273 134 34551492
Uveitis 59.81 11.68 208 405097 7327 34544299
Night sweats 59.73 11.68 375 404930 16977 34534649
Cardiac failure congestive 59.62 11.68 647 404658 82623 34469003
Neutrophil count decreased 59.40 11.68 348 404957 50756 34500870
Cerebral aspergillosis 59.28 11.68 78 405227 1354 34550272
Disseminated tuberculosis 59.26 11.68 98 405207 2107 34549519
Fistula 58.86 11.68 194 405111 6646 34544980
Accidental overdose 58.69 11.68 89 405216 20051 34531575
Disseminated cryptococcosis 58.16 11.68 76 405229 1310 34550316
Hallucination, auditory 57.93 11.68 33 405272 11884 34539742
Subdural haematoma 57.83 11.68 92 405213 20329 34531297
Coccidioidomycosis 57.79 11.68 57 405248 710 34550916
Poor venous access 57.77 11.68 161 405144 5022 34546604
Enterococcal infection 57.41 11.68 237 405068 9069 34542557
Gamma-glutamyltransferase increased 57.37 11.68 162 405143 29069 34522557
B-cell lymphoma recurrent 57.35 11.68 58 405247 746 34550880
Bronchopulmonary aspergillosis allergic 57.29 11.68 62 405243 867 34550759
Heart transplant rejection 57.18 11.68 71 405234 1160 34550466
Pulmonary function test abnormal 57.15 11.68 106 405199 2504 34549122
Urinary retention 56.86 11.68 222 405083 36066 34515560
Bladder cancer 56.63 11.68 63 405242 16215 34535411
Herpes simplex 56.46 11.68 167 405138 5392 34546234
Pulmonary oedema 56.12 11.68 322 404983 47207 34504419
Nightmare 55.42 11.68 51 405254 14340 34537286
Anaphylactic shock 55.12 11.68 62 405243 15879 34535747
Gastrointestinal haemorrhage 55.05 11.68 709 404596 87768 34463858
Balance disorder 54.96 11.68 263 405042 40391 34511235
Muscle rigidity 54.25 11.68 27 405278 10491 34541135
Psychotic disorder 53.75 11.68 128 405177 24324 34527302
Myocardial ischaemia 53.61 11.68 74 405231 17334 34534292
Haemophagocytic lymphohistiocytosis 53.48 11.68 294 405011 12679 34538947
Melaena 53.19 11.68 220 405085 35160 34516466
Crohn's disease 53.11 11.68 114 405191 3003 34548623
Foetal exposure during pregnancy 52.97 11.68 244 405061 37857 34513769
Inflammation 52.82 11.68 531 404774 27764 34523862
Sinus bradycardia 52.26 11.68 44 405261 12919 34538707
Trichodysplasia spinulosa 52.00 11.68 34 405271 221 34551405
Drug eruption 51.44 11.68 95 405210 19803 34531823
Joint stiffness 51.43 11.68 256 405049 10617 34541009
Spirometry abnormal 51.23 11.68 52 405253 672 34550954
Tremor 50.94 11.68 663 404642 81924 34469702
Dry mouth 50.88 11.68 179 405126 29986 34521640
Therapeutic response decreased 50.88 11.68 542 404763 28771 34522855
Amnesia 50.83 11.68 149 405156 26414 34525212
Bronchial obstruction 50.57 11.68 77 405228 1539 34550087
Anaemia 50.56 11.68 2201 403104 231134 34320492
Blood bilirubin increased 50.46 11.68 250 405055 38046 34513580
Body temperature decreased 50.17 11.68 290 405015 12744 34538882
Dystonia 49.96 11.68 32 405273 10813 34540813
Akathisia 49.69 11.68 16 405289 8093 34543533
Skin mass 49.66 11.68 129 405176 3856 34547770
Gastroenteritis norovirus 49.58 11.68 74 405231 1452 34550174
Epidermodysplasia verruciformis 49.57 11.68 33 405272 222 34551404
Enterovirus infection 49.26 11.68 59 405246 927 34550699
Cardiogenic shock 49.00 11.68 152 405153 26466 34525160
Poisoning deliberate 48.92 11.68 15 405290 7829 34543797
Body temperature fluctuation 48.77 11.68 77 405228 1590 34550036
Mydriasis 48.58 11.68 12 405293 7225 34544401
Nasal obstruction 48.41 11.68 49 405256 631 34550995
Malignant fibrous histiocytoma 48.34 11.68 31 405274 194 34551432
Hypomagnesaemia 48.34 11.68 114 405191 21737 34529889
Mycobacterium chelonae infection 47.84 11.68 53 405252 762 34550864
Blood pressure diastolic increased 47.32 11.68 147 405158 4878 34546748
Medial tibial stress syndrome 47.05 11.68 18 405287 25 34551601
Drug specific antibody present 46.90 11.68 112 405193 3173 34548453
Abscess 46.84 11.68 265 405040 11552 34540074
Diabetes mellitus 46.83 11.68 784 404521 46089 34505537
Diffuse large B-cell lymphoma refractory 46.40 11.68 65 405240 1201 34550425
COVID-19 pneumonia 46.12 11.68 346 404959 16621 34535005
Sinusitis 46.06 11.68 705 404600 40697 34510929
Diarrhoea 45.95 11.68 3895 401410 386017 34165609
Myoclonus 45.94 11.68 62 405243 14663 34536963
Renal graft infection 45.63 11.68 33 405272 258 34551368
Muscle spasms 45.55 11.68 604 404701 74397 34477229
Mycotic allergy 45.47 11.68 45 405260 563 34551063
Rheumatoid factor positive 45.26 11.68 48 405257 655 34550971
Drug level above therapeutic 45.19 11.68 130 405175 4131 34547495
Liver transplant rejection 45.07 11.68 85 405220 2034 34549592
Parkinsonism 44.91 11.68 19 405286 8119 34543507
Arrhythmia 44.78 11.68 238 405067 35570 34516056
Ventricular tachycardia 44.64 11.68 158 405147 26421 34525205
Cryptococcal cutaneous infection 44.33 11.68 22 405283 76 34551550
Delusion 43.84 11.68 49 405256 12586 34539040
Product substitution issue 43.56 11.68 32 405273 10063 34541563
Pneumoperitoneum 43.41 11.68 76 405229 1714 34549912
Pneumonia cryptococcal 43.38 11.68 53 405252 851 34550775
Infusion related reaction 43.38 11.68 860 404445 52197 34499429
Therapy non-responder 42.94 11.68 665 404640 38481 34513145
Colectomy 42.75 11.68 77 405228 1777 34549849
Nasopharyngitis 42.70 11.68 1088 404217 68880 34482746
Shock 42.46 11.68 141 405164 24038 34527588
Withdrawal syndrome 42.46 11.68 49 405256 12406 34539220
Respiratory failure 42.21 11.68 1598 403707 106974 34444652
Foot deformity 42.05 11.68 132 405173 4405 34547221
Chronic sinusitis 41.92 11.68 86 405219 2193 34549433
Second primary malignancy 41.89 11.68 192 405113 7694 34543932
Graft versus host disease in skin 41.87 11.68 120 405185 3805 34547821
Allergy to animal 41.72 11.68 36 405269 373 34551253
Product quality issue 41.71 11.68 84 405221 16951 34534675
Visceral leishmaniasis 41.57 11.68 43 405262 569 34551057
Epilepsy 41.54 11.68 120 405185 21375 34530251
Arthritis bacterial 41.44 11.68 142 405163 4964 34546662
Hepatic cytolysis 41.34 11.68 65 405240 14431 34537195
Sporotrichosis 40.96 11.68 19 405286 54 34551572
Oropharyngeal pain 40.93 11.68 608 404697 34877 34516749
Disseminated varicella zoster virus infection 40.57 11.68 32 405273 289 34551337
Hypogammaglobulinaemia 40.05 11.68 187 405118 7553 34544073
Skin lesion 39.97 11.68 410 404895 21551 34530075
Product dose omission issue 39.96 11.68 1069 404236 118642 34432984
Right atrial hypertrophy 39.94 11.68 48 405257 757 34550869
Breath sounds abnormal 39.92 11.68 172 405133 6709 34544917
Blood pressure systolic increased 39.65 11.68 424 404881 22528 34529098
Psoriatic arthropathy 39.62 11.68 377 404928 19421 34532205
Epstein-Barr virus associated lymphoproliferative disorder 39.58 11.68 77 405228 1887 34549739
Palpitations 39.50 11.68 286 405019 39700 34511926
Hypokalaemia 39.41 11.68 458 404847 57756 34493870
Dermatophytosis 39.22 11.68 28 405277 214 34551412
Toxic epidermal necrolysis 38.86 11.68 125 405180 21521 34530105
Product administration error 38.83 11.68 82 405223 16262 34535364
Lung hyperinflation 38.78 11.68 50 405255 850 34550776
Lung opacity 38.74 11.68 85 405220 2274 34549352
Mantle cell lymphoma recurrent 38.69 11.68 46 405259 717 34550909
Smooth muscle cell neoplasm 38.54 11.68 25 405280 160 34551466
Disseminated coccidioidomycosis 38.42 11.68 19 405286 65 34551561
Hallucination, visual 38.42 11.68 94 405211 17697 34533929
Medication error 38.40 11.68 159 405146 25406 34526220
Incorrect route of product administration 38.26 11.68 71 405234 14774 34536852
Suspected suicide 38.06 11.68 5 405300 4743 34546883
End stage renal disease 38.00 11.68 203 405102 8658 34542968
Chest pain 37.99 11.68 1149 404156 125613 34426013
Babesiosis 37.99 11.68 23 405282 128 34551498
Human polyomavirus infection 37.96 11.68 45 405260 699 34550927
Salivary hypersecretion 37.82 11.68 27 405278 8617 34543009
Obsessive-compulsive disorder 37.79 11.68 9 405296 5555 34546071
Asphyxia 37.65 11.68 16 405289 6819 34544807
Cataract 37.30 11.68 466 404839 25720 34525906
Acanthamoeba infection 37.01 11.68 34 405271 385 34551241
Vital capacity decreased 36.97 11.68 33 405272 359 34551267
Abnormal dreams 36.81 11.68 21 405284 7557 34544069
Muscle twitching 36.77 11.68 39 405266 10259 34541367
Choroiditis 36.76 11.68 57 405248 1158 34550468
Lymphadenitis 36.68 11.68 76 405229 1952 34549674
Acute myeloid leukaemia 36.61 11.68 348 404957 17922 34533704
Delayed graft function 36.44 11.68 80 405225 2141 34549485
Hypofibrinogenaemia 36.32 11.68 68 405237 1618 34550008
Bradyphrenia 36.27 11.68 6 405299 4792 34546834
Ventricular extrasystoles 36.02 11.68 52 405253 11956 34539670
Speech disorder 35.99 11.68 164 405141 25522 34526104
Mass 35.90 11.68 184 405121 7721 34543905
Scleroderma 35.88 11.68 65 405240 1507 34550119
Osteomyelitis fungal 35.87 11.68 27 405278 226 34551400
Coombs positive haemolytic anaemia 35.77 11.68 50 405255 922 34550704
Respiratory disorder 35.70 11.68 361 404944 18903 34532723
Insomnia 35.69 11.68 924 404381 102983 34448643
Nephropathy toxic 35.52 11.68 259 405046 12329 34539297
Aphthous ulcer 35.50 11.68 133 405172 4862 34546764
Haematuria 35.42 11.68 390 404915 49676 34501950
Polyomavirus viraemia 35.35 11.68 49 405256 896 34550730
Necrotising oesophagitis 35.30 11.68 38 405267 528 34551098
Endophthalmitis 35.26 11.68 105 405200 3403 34548223
Coma scale abnormal 35.25 11.68 3 405302 4005 34547621
Lymphoproliferative disorder 35.09 11.68 90 405215 2669 34548957
Influenza 35.06 11.68 788 404517 48878 34502748
Mite allergy 35.06 11.68 42 405263 660 34550966
Sopor 35.00 11.68 54 405251 12082 34539544
Acne 34.93 11.68 234 405071 10832 34540794
Graft versus host disease in gastrointestinal tract 34.92 11.68 108 405197 3575 34548051
Tardive dyskinesia 34.47 11.68 12 405293 5778 34545848
Bronchial secretion retention 34.41 11.68 63 405242 1473 34550153
Small for dates baby 34.37 11.68 3 405302 3924 34547702
Sexual dysfunction 34.33 11.68 15 405290 6288 34545338
Ataxia 34.18 11.68 68 405237 13785 34537841
Electrocardiogram abnormal 34.17 11.68 34 405271 9213 34542413
Myalgia 34.16 11.68 729 404576 83381 34468245
Pericarditis fungal 34.01 11.68 22 405283 140 34551486
Dysplastic naevus 33.96 11.68 35 405270 461 34551165
Vascular hyalinosis 33.93 11.68 18 405287 74 34551552
Fear 33.82 11.68 43 405262 10433 34541193
Renal impairment 33.66 11.68 836 404469 93677 34457949
Electrolyte imbalance 33.66 11.68 73 405232 14339 34537287
Pneumonia pseudomonal 33.54 11.68 111 405194 3811 34547815
Pruritus 33.51 11.68 1326 403979 140655 34410971
Staphylococcal infection 33.47 11.68 550 404755 32210 34519416
Upper-airway cough syndrome 33.42 11.68 104 405201 3454 34548172
Intercepted product preparation error 33.41 11.68 4 405301 4074 34547552
Myopathy 33.34 11.68 239 405066 11315 34540311
Chest discomfort 33.28 11.68 848 404457 53682 34497944
Diabetic ketoacidosis 33.17 11.68 103 405202 17929 34533697
Exposure during pregnancy 32.84 11.68 33 405272 8901 34542725
Conjunctivitis allergic 32.79 11.68 53 405252 1117 34550509
Solar lentigo 32.74 11.68 36 405269 513 34551113
Upper respiratory fungal infection 32.70 11.68 22 405283 151 34551475
Stomatitis 32.59 11.68 325 404980 42189 34509437
Dysphagia 32.41 11.68 518 404787 61863 34489763
Upper gastrointestinal haemorrhage 32.25 11.68 169 405136 25349 34526277
Central nervous system lymphoma 32.19 11.68 49 405256 979 34550647
Steroid withdrawal syndrome 32.12 11.68 25 405280 221 34551405
Dysgeusia 32.09 11.68 178 405127 26319 34525307
Muscle spasticity 32.09 11.68 14 405291 5874 34545752
Blood cholesterol 31.87 11.68 24 405281 201 34551425
Blood alkaline phosphatase increased 31.75 11.68 221 405084 30954 34520672
Tendon disorder 31.74 11.68 89 405216 2786 34548840
Cerebral toxoplasmosis 31.72 11.68 65 405240 1656 34549970
Transplant failure 31.68 11.68 102 405203 3451 34548175
Pancreatic carcinoma 31.46 11.68 34 405271 8867 34542759
Euphoric mood 31.40 11.68 13 405292 5628 34545998
Squamous cell carcinoma of skin 31.35 11.68 225 405080 10656 34540970
Cyanosis 31.20 11.68 63 405242 12701 34538925
Squamous cell carcinoma 31.18 11.68 234 405071 11241 34540385
Multiple sclerosis relapse 31.10 11.68 66 405239 13067 34538559
Tendon rupture 31.00 11.68 162 405143 6850 34544776
Hiccups 30.90 11.68 43 405262 10039 34541587
Granulocytopenia 30.77 11.68 19 405286 6548 34545078
Blood pressure diastolic abnormal 30.75 11.68 124 405181 4694 34546932
Pneumonia fungal 30.68 11.68 163 405142 6937 34544689
Toxic skin eruption 30.65 11.68 53 405252 11332 34540294
Gastrointestinal inflammation 30.59 11.68 100 405205 3411 34548215
Pemphigus 30.53 11.68 62 405243 1569 34550057
Head injury 30.47 11.68 108 405197 18052 34533574
Abdominal abscess 30.36 11.68 112 405193 4063 34547563
Restrictive pulmonary disease 30.35 11.68 52 405253 1152 34550474
Complications of transplanted lung 30.32 11.68 23 405282 195 34551431
Photodermatosis 30.30 11.68 35 405270 528 34551098
Metabolic acidosis 30.21 11.68 342 404963 43338 34508288
Tuberculosis gastrointestinal 30.14 11.68 24 405281 220 34551406
Mobility decreased 30.11 11.68 504 404801 29624 34522002
Meningitis listeria 30.08 11.68 33 405272 469 34551157
Blood urea increased 30.07 11.68 217 405088 30147 34521479
Syringe issue 30.04 11.68 14 405291 5650 34545976
Pulmonary mucormycosis 29.89 11.68 41 405264 742 34550884
Skin squamous cell carcinoma recurrent 29.88 11.68 14 405291 41 34551585
Antineutrophil cytoplasmic antibody positive 29.85 11.68 41 405264 743 34550883
Oedema peripheral 29.79 11.68 1112 404193 118700 34432926
Accidental exposure to product 29.77 11.68 65 405240 12737 34538889
Central nervous system infection 29.65 11.68 38 405267 642 34550984
Cardiomegaly 29.24 11.68 87 405218 15351 34536275
Cytomegalovirus gastrointestinal infection 29.14 11.68 23 405282 208 34551418
Atrial fibrillation 29.10 11.68 1142 404163 121251 34430375
Appendicitis 29.10 11.68 82 405223 14725 34536901
Necrotising retinitis 29.05 11.68 42 405263 800 34550826
Hypothermia 28.96 11.68 50 405255 10698 34540928
Corynebacterium infection 28.96 11.68 36 405269 589 34551037
Drug ineffective for unapproved indication 28.79 11.68 410 404895 23305 34528321
Cytology abnormal 28.74 11.68 29 405276 372 34551254
Pain 28.64 11.68 2750 402555 201925 34349701
Bronchial hyperreactivity 28.54 11.68 62 405243 1647 34549979
Psychomotor hyperactivity 28.54 11.68 42 405263 9580 34542046
Unevaluable event 28.50 11.68 241 405064 32349 34519277
Prescribed underdose 28.49 11.68 37 405268 8896 34542730
Prostate cancer metastatic 28.42 11.68 138 405167 5665 34545961
Cytomegalovirus chorioretinitis 28.42 11.68 99 405206 3490 34548136
Exposure to SARS-CoV-2 28.41 11.68 33 405272 501 34551125
Cerebral fungal infection 28.37 11.68 25 405280 267 34551359
Aphasia 28.29 11.68 140 405165 21314 34530312
Cutaneous sporotrichosis 28.26 11.68 13 405292 36 34551590
Pulmonary fibrosis 28.21 11.68 332 404973 18064 34533562
Full blood count decreased 28.11 11.68 111 405194 17977 34533649
Lipodystrophy acquired 28.10 11.68 3 405302 3341 34548285
Mycobacterium abscessus infection 27.92 11.68 33 405272 511 34551115
Sudden death 27.84 11.68 87 405218 15114 34536512
Mental impairment 27.83 11.68 48 405257 10274 34541352
Listeria encephalitis 27.77 11.68 13 405292 38 34551588
Hepatic encephalopathy 27.64 11.68 83 405222 14602 34537024
Lung consolidation 27.54 11.68 139 405166 5797 34545829
Drug screen positive 27.53 11.68 6 405299 3937 34547689
Congenital hiatus hernia 27.53 11.68 41 405264 803 34550823
Ill-defined disorder 27.40 11.68 264 405041 13645 34537981
Prescribed overdose 27.37 11.68 51 405254 10596 34541030
Cutaneous blastomycosis 27.34 11.68 11 405294 19 34551607
Herpes zoster cutaneous disseminated 27.29 11.68 20 405285 160 34551466
Injury 27.28 11.68 135 405170 20552 34531074
Synovitis 27.23 11.68 266 405039 13800 34537826
Periostitis 27.22 11.68 25 405280 283 34551343
Wrong product administered 27.05 11.68 14 405291 5320 34546306
Priapism 27.02 11.68 12 405293 4982 34546644
Myelodysplastic syndrome 27 11.68 341 404964 18867 34532759
Status epilepticus 26.96 11.68 67 405238 12547 34539079
Angina pectoris 26.95 11.68 233 405072 31130 34520496
Cat scratch disease 26.89 11.68 20 405285 164 34551462
Cell-mediated immune deficiency 26.83 11.68 13 405292 42 34551584
B-cell lymphoma 26.82 11.68 111 405194 4252 34547374
Emotional distress 26.81 11.68 87 405218 14939 34536687
Leukopenia 26.81 11.68 935 404370 61921 34489705
Euglycaemic diabetic ketoacidosis 26.79 11.68 3 405302 3219 34548407
Epstein-Barr virus test positive 26.54 11.68 33 405272 540 34551086
Renal failure 26.49 11.68 1240 404065 129317 34422309
Blood potassium increased 26.42 11.68 100 405205 16395 34535231
Atrial septal defect 26.39 11.68 28 405277 7364 34544262
Mycoplasma infection 26.35 11.68 28 405277 383 34551243
Meningitis enterococcal 26.34 11.68 15 405290 73 34551553
Obliterative bronchiolitis 26.33 11.68 50 405255 1203 34550423
Synovial cyst 26.31 11.68 73 405232 2271 34549355
Loss of therapeutic response 26.28 11.68 34 405271 580 34551046
Anxiety 26.25 11.68 916 404389 98512 34453114
Post transplant distal limb syndrome 26.18 11.68 24 405281 271 34551355
Plasma cell myeloma 26.07 11.68 337 404968 41700 34509926
Mycobacterium marinum infection 26.04 11.68 24 405281 273 34551353
Blood glucose increased 26.01 11.68 582 404723 66136 34485490
Stenotrophomonas infection 25.98 11.68 68 405237 2042 34549584
Angiosarcoma metastatic 25.97 11.68 13 405292 46 34551580
Lung disorder 25.92 11.68 555 404750 34141 34517485
Nodular regenerative hyperplasia 25.82 11.68 43 405262 930 34550696
Chronic graft versus host disease in skin 25.79 11.68 43 405262 931 34550695
Nodule 25.77 11.68 151 405154 6668 34544958
Emphysematous pyelonephritis 25.76 11.68 13 405292 47 34551579
Ventricular remodelling 25.72 11.68 15 405290 77 34551549
Diarrhoea haemorrhagic 25.71 11.68 150 405155 6614 34545012
Primary effusion lymphoma 25.70 11.68 11 405294 24 34551602
Tuberculosis 25.67 11.68 179 405126 8398 34543228
Anal abscess 25.55 11.68 145 405160 6328 34545298
Epstein-Barr virus associated lymphoma 25.54 11.68 35 405270 633 34550993
Microsporidia infection 25.51 11.68 36 405269 670 34550956
Acquired apparent mineralocorticoid excess 25.41 11.68 12 405293 36 34551590
Middle insomnia 25.31 11.68 150 405155 6652 34544974
Superinfection bacterial 25.27 11.68 41 405264 867 34550759
Hypernatraemia 25.24 11.68 37 405268 8453 34543173
Apnoea 25.21 11.68 24 405281 6640 34544986
Hyperthermia 25.18 11.68 53 405252 10524 34541102
Immunosuppressant drug level decreased 25.07 11.68 49 405256 1205 34550421
Bacterial pyelonephritis 24.89 11.68 22 405283 236 34551390
Vocal cord dysfunction 24.87 11.68 19 405286 163 34551463
Sinusitis bacterial 24.83 11.68 29 405276 443 34551183
Lip swelling 24.78 11.68 99 405206 15981 34535645
Bronchial disorder 24.70 11.68 52 405253 1351 34550275
Empyema 24.54 11.68 88 405217 3148 34548478
Device leakage 24.50 11.68 24 405281 6551 34545075
Malignant transformation 24.47 11.68 39 405266 812 34550814
Blood pressure decreased 24.40 11.68 435 404870 51080 34500546
Inflammatory bowel disease 24.40 11.68 82 405223 2838 34548788
Pneumonia necrotising 24.39 11.68 37 405268 737 34550889
Diabetic cardiomyopathy 24.26 11.68 10 405295 19 34551607
Atrioventricular block first degree 24.16 11.68 21 405284 6071 34545555
Red blood cell count decreased 24.16 11.68 218 405087 28872 34522754
Acinetobacter infection 23.94 11.68 47 405258 1160 34550466
Lethargy 23.93 11.68 334 404971 40788 34510838
Hypothyroidism 23.92 11.68 143 405162 20759 34530867
Drug intolerance 23.90 11.68 880 404425 58690 34492936
Chronic kidney disease 23.88 11.68 335 404970 40875 34510751
Cytopenia 23.85 11.68 239 405066 12484 34539142
Blood sodium decreased 23.83 11.68 102 405203 16149 34535477
Histoplasmosis cutaneous 23.78 11.68 11 405294 31 34551595
Psychiatric decompensation 23.77 11.68 3 405302 2934 34548692
Right ventricular hypertrophy 23.76 11.68 54 405251 1480 34550146
Cardiac failure chronic 23.75 11.68 34 405271 7845 34543781
Blood phosphorus increased 23.59 11.68 33 405272 7688 34543938
Dementia 23.57 11.68 81 405224 13667 34537959
Carotid artery occlusion 23.57 11.68 7 405298 3730 34547896
Haematocrit decreased 23.57 11.68 249 405056 31967 34519659
Lactobacillus infection 23.54 11.68 23 405282 283 34551343
Emphysema 23.54 11.68 190 405115 9335 34542291
Immune reconstitution inflammatory syndrome 23.45 11.68 178 405127 8581 34543045
Kaposi's sarcoma 23.40 11.68 39 405266 844 34550782
Hypertonia 23.29 11.68 10 405295 4236 34547390
Trichophytosis 23.29 11.68 23 405282 287 34551339
Respiratory symptom 23.25 11.68 59 405246 1738 34549888
Anal fissure 23.20 11.68 105 405200 4185 34547441
Clear cell renal cell carcinoma 23.16 11.68 45 405260 1102 34550524
Cytomegalovirus infection reactivation 23.15 11.68 119 405186 4999 34546627
Generalised tonic-clonic seizure 23.12 11.68 147 405158 21027 34530599
Opportunistic infection 23.10 11.68 56 405249 1602 34550024
Graft versus host disease 23.04 11.68 205 405100 10364 34541262
Hyperglycaemia 22.93 11.68 610 404695 38870 34512756
Mood altered 22.91 11.68 43 405262 8909 34542717
Eosinophil count 22.90 11.68 17 405288 139 34551487
Somnambulism 22.87 11.68 4 405301 3068 34548558
Ammonia increased 22.86 11.68 11 405294 4358 34547268
Rash maculo-papular 22.85 11.68 215 405090 28236 34523390
Apparent mineralocorticoid excess 22.83 11.68 11 405294 35 34551591
Hydronephrosis 22.72 11.68 201 405104 10145 34541481
Lymph node calcification 22.71 11.68 17 405288 141 34551485
Mycobacterium fortuitum infection 22.61 11.68 18 405287 165 34551461
Listeriosis 22.53 11.68 42 405263 996 34550630
Capnocytophaga infection 22.40 11.68 15 405290 102 34551524
Postoperative thoracic procedure complication 22.38 11.68 11 405294 37 34551589
Blood pressure systolic abnormal 22.38 11.68 98 405207 3850 34547776
T-cell lymphoma 22.35 11.68 41 405264 960 34550666
Colectomy total 22.35 11.68 18 405287 168 34551458
Atrioventricular block second degree 22.30 11.68 8 405297 3780 34547846
Joint lock 22.15 11.68 47 405258 1228 34550398
Diaphragmatic hernia 22.10 11.68 21 405284 249 34551377
Presyncope 22.02 11.68 130 405175 18929 34532697
Intestinal perforation 21.99 11.68 180 405125 8880 34542746
Chronic obstructive pulmonary disease 21.95 11.68 732 404573 48186 34503440
Spinal instability 21.88 11.68 24 405281 341 34551285
Eye infection syphilitic 21.82 11.68 7 405298 3 34551623
Plasmablastic lymphoma 21.77 11.68 24 405281 343 34551283
Psychomotor skills impaired 21.75 11.68 9 405296 3897 34547729
Rectal tenesmus 21.74 11.68 37 405268 815 34550811
Ketoacidosis 21.72 11.68 11 405294 4232 34547394
Drug effective for unapproved indication 21.68 11.68 73 405232 2529 34549097
Prothrombin time prolonged 21.67 11.68 48 405257 9358 34542268
Nasal oedema 21.61 11.68 24 405281 346 34551280
Granulomatosis with polyangiitis 21.61 11.68 45 405260 1160 34550466
Infectious thyroiditis 21.53 11.68 14 405291 90 34551536
Erythema nodosum 21.51 11.68 49 405256 1345 34550281
Coronavirus infection 21.51 11.68 103 405202 4204 34547422
Lupus nephritis 21.45 11.68 24 405281 349 34551277
Acute febrile neutrophilic dermatosis 21.45 11.68 47 405258 1256 34550370
Obstructive nephropathy 21.42 11.68 10 405295 29 34551597
Cryptococcal fungaemia 21.41 11.68 14 405291 91 34551535
Disseminated aspergillosis 21.41 11.68 35 405270 745 34550881
Alcohol abuse 21.38 11.68 14 405291 4676 34546950
Atlantoaxial instability 21.23 11.68 23 405282 322 34551304
Disseminated Bacillus Calmette-Guerin infection 21.21 11.68 18 405287 182 34551444
Depressed mood 21.15 11.68 134 405171 19183 34532443
Viral infection 21.12 11.68 304 405001 17319 34534307
Blood creatinine increased 21.11 11.68 893 404412 94083 34457543
Complications of transplanted heart 21.10 11.68 22 405283 294 34551332
Homicidal ideation 21.08 11.68 3 405302 2679 34548947
Ventricular septal defect 21.05 11.68 10 405295 3991 34547635
Hepatic cancer 20.95 11.68 40 405265 8235 34543391
Acquired haemophilia 20.85 11.68 40 405265 970 34550656
Pleural thickening 20.83 11.68 24 405281 361 34551265
Secondary immunodeficiency 20.77 11.68 25 405280 395 34551231
Anaphylactic reaction 20.76 11.68 257 405048 32044 34519582
Scleritis 20.74 11.68 29 405276 535 34551091
Tuberculosis of central nervous system 20.67 11.68 18 405287 189 34551437
Colorectal cancer 20.66 11.68 15 405290 4746 34546880
Drug abuser 20.62 11.68 10 405295 3944 34547682
Nasal disorder 20.62 11.68 59 405246 1869 34549757
Sarcoidosis 20.61 11.68 77 405228 2811 34548815
Endocarditis bacterial 20.60 11.68 39 405266 936 34550690
Parathyroid gland enlargement 20.60 11.68 16 405289 141 34551485
Graft infection 20.43 11.68 26 405279 436 34551190
Neutrophilic dermatosis 20.42 11.68 19 405286 219 34551407
Dermatitis acneiform 20.40 11.68 25 405280 6164 34545462
Blood thyroid stimulating hormone increased 20.37 11.68 12 405293 4243 34547383
Chorioretinopathy 20.35 11.68 50 405255 1443 34550183
Cystitis haemorrhagic 20.34 11.68 124 405181 5555 34546071
Physical disability 20.30 11.68 48 405257 1351 34550275
Chromaturia 20.17 11.68 93 405212 14427 34537199
Drooling 20.15 11.68 7 405298 3375 34548251
Peripheral arterial occlusive disease 20.14 11.68 23 405282 5851 34545775
Glycosylated haemoglobin increased 20.11 11.68 66 405239 11294 34540332
Hepatosplenic T-cell lymphoma 20.08 11.68 26 405279 444 34551182
Toxoplasmosis 20.02 11.68 46 405259 1270 34550356
Herpes oesophagitis 19.98 11.68 16 405289 148 34551478
Dislocation of vertebra 19.97 11.68 25 405280 412 34551214
Neuropathy peripheral 19.97 11.68 776 404529 82487 34469139
Wrist deformity 19.96 11.68 23 405282 346 34551280
Cold sweat 19.85 11.68 55 405250 9932 34541694
Ankylosing spondylitis 19.84 11.68 122 405183 5482 34546144
Skin bacterial infection 19.82 11.68 14 405291 105 34551521
Mineral metabolism disorder 19.81 11.68 23 405282 349 34551277
Cutaneous nocardiosis 19.73 11.68 16 405289 151 34551475
Donor specific antibody present 19.72 11.68 14 405291 106 34551520
Vasculitis 19.66 11.68 209 405096 11087 34540539
Demodicidosis 19.65 11.68 18 405287 203 34551423
Exposure to toxic agent 19.62 11.68 9 405296 3666 34547960
Faecaloma 19.61 11.68 20 405285 5357 34546269
Eosinophil count increased 19.58 11.68 168 405137 8404 34543222
Type 2 lepra reaction 19.56 11.68 17 405288 178 34551448
Gynaecomastia 19.55 11.68 57 405248 10123 34541503
Red blood cell sedimentation rate abnormal 19.52 11.68 88 405217 3501 34548125
Cutaneous mucormycosis 19.48 11.68 17 405288 179 34551447
Systemic infection 19.45 11.68 19 405286 5193 34546433
Eosinophilic bronchitis 19.45 11.68 18 405287 206 34551420
Blood test abnormal 19.42 11.68 143 405162 6828 34544798
Psychomotor retardation 19.39 11.68 9 405296 3641 34547985
Social avoidant behaviour 19.34 11.68 6 405299 3108 34548518
Rhinorrhoea 19.30 11.68 411 404894 25257 34526369
Orf 19.30 11.68 9 405296 26 34551600
Electrocardiogram QRS complex prolonged 19.26 11.68 17 405288 4877 34546749
Skin necrosis 19.22 11.68 125 405180 5728 34545898
Sinus congestion 19.21 11.68 121 405184 5484 34546142
Osteomyelitis 19.20 11.68 278 405027 15858 34535768
Heart rate increased 19.17 11.68 687 404618 45656 34505970
On and off phenomenon 19.15 11.68 3 405302 2494 34549132
Skeletal injury 19.13 11.68 25 405280 431 34551195
IgA nephropathy 19.05 11.68 44 405261 1219 34550407
Bacterial sepsis 19.04 11.68 115 405190 5135 34546491
Immunodeficiency 19.03 11.68 119 405186 5379 34546247
Abdominal wall abscess 18.99 11.68 27 405278 506 34551120
Device occlusion 18.99 11.68 29 405276 6516 34545110
Encephalitis 18.99 11.68 147 405158 7130 34544496
Ileostomy 18.96 11.68 31 405274 660 34550966
Sleep disorder due to general medical condition, insomnia type 18.93 11.68 45 405260 1271 34550355
Rheumatoid nodule 18.93 11.68 76 405229 2871 34548755
Pleomorphic malignant fibrous histiocytoma 18.82 11.68 9 405296 28 34551598
Lower respiratory tract congestion 18.79 11.68 43 405262 1184 34550442
Tumour lysis syndrome 18.78 11.68 290 405015 16769 34534857
Lymphadenopathy mediastinal 18.77 11.68 68 405237 2445 34549181
Nipple swelling 18.74 11.68 21 405284 306 34551320
Blood potassium decreased 18.74 11.68 126 405179 17789 34533837
Disseminated mucormycosis 18.72 11.68 27 405278 513 34551113
Clostridium difficile colitis 18.71 11.68 271 405034 15459 34536167
Cytomegalovirus nephritis 18.71 11.68 14 405291 116 34551510
Haemolysis 18.68 11.68 159 405146 7935 34543691
Urinary incontinence 18.63 11.68 135 405170 18739 34532887
Hand deformity 18.54 11.68 89 405216 3636 34547990
Throat irritation 18.49 11.68 196 405109 10389 34541237
Gastric cancer 18.45 11.68 29 405276 6440 34545186
Angina unstable 18.43 11.68 71 405234 11582 34540044
Skin striae 18.39 11.68 29 405276 598 34551028
Osteomyelitis acute 18.39 11.68 19 405286 251 34551375
BK polyomavirus test positive 18.37 11.68 9 405296 30 34551596
Chondropathy 18.31 11.68 37 405268 933 34550693
Colostomy 18.30 11.68 26 405279 487 34551139
Ileal ulcer 18.29 11.68 29 405276 601 34551025
Abscess intestinal 18.22 11.68 51 405254 1595 34550031
Pancreatitis acute 18.04 11.68 224 405081 27917 34523709
Lymphocele 18.02 11.68 45 405260 1312 34550314
Transient ischaemic attack 18.01 11.68 219 405086 27394 34524232
Haemorrhagic stroke 18.01 11.68 30 405275 6509 34545117
Reversible airways obstruction 17.76 11.68 25 405280 464 34551162
Escherichia sepsis 17.67 11.68 104 405201 4600 34547026
Lung infiltration 17.67 11.68 228 405077 12677 34538949
Autoinflammatory disease 17.67 11.68 10 405295 48 34551578
Erythema multiforme 17.67 11.68 47 405258 8602 34543024
Pancreas transplant rejection 17.64 11.68 16 405289 178 34551448
Zoonotic bacterial infection 17.51 11.68 10 405295 49 34551577
Subarachnoid haemorrhage 17.51 11.68 81 405224 12554 34539072
Unintentional medical device removal 17.49 11.68 5 405300 2731 34548895
Rectal abscess 17.37 11.68 45 405260 1343 34550283
Petit mal epilepsy 17.29 11.68 7 405298 3071 34548555
Thrombotic microangiopathy 17.26 11.68 194 405111 10436 34541190
Device difficult to use 17.26 11.68 6 405299 2891 34548735
Hypocalcaemia 17.25 11.68 189 405116 24100 34527526
Acute pulmonary histoplasmosis 17.19 11.68 15 405290 158 34551468
Acute promyelocytic leukaemia 17.14 11.68 25 405280 480 34551146
Mitochondrial toxicity 17.12 11.68 5 405300 2694 34548932
Atrioventricular block 17.10 11.68 43 405262 8020 34543606
Behaviour disorder 17.08 11.68 19 405286 4891 34546735
Autism spectrum disorder 17.07 11.68 3 405302 2293 34549333
Joint range of motion decreased 17.07 11.68 144 405161 7168 34544458
Disability 17.04 11.68 104 405201 4661 34546965
Gastroenteritis cryptosporidial 17.02 11.68 16 405289 187 34551439
Gastroenteritis Escherichia coli 17.02 11.68 22 405283 375 34551251
Complications of transplant surgery 16.96 11.68 25 405280 485 34551141
Intervertebral disc degeneration 16.95 11.68 130 405175 6287 34545339
Liver injury 16.91 11.68 102 405203 14776 34536850
Forced expiratory volume 16.88 11.68 13 405292 113 34551513
Pleocytosis 16.85 11.68 26 405279 526 34551100
Tachypnoea 16.82 11.68 134 405171 18218 34533408
Tearfulness 16.81 11.68 5 405300 2662 34548964
Drug level abnormal 16.75 11.68 16 405289 191 34551435
Sinus tachycardia 16.74 11.68 125 405180 17235 34534391
Urinary tract infection neonatal 16.72 11.68 6 405299 6 34551620
Peripheral swelling 16.72 11.68 1065 404240 75476 34476150
Oxalosis 16.70 11.68 8 405297 25 34551601
Azoospermia 16.70 11.68 23 405282 418 34551208
Granulomatous dermatitis 16.67 11.68 18 405287 251 34551375
Impaired healing 16.62 11.68 260 405045 15074 34536552
Infective myositis 16.61 11.68 10 405295 55 34551571
Colon injury 16.61 11.68 9 405296 39 34551587
Aspergilloma 16.57 11.68 20 405285 317 34551309
Joint injury 16.56 11.68 171 405134 9002 34542624
Intracranial pressure increased 16.55 11.68 90 405215 3865 34547761
Urinary tract infection bacterial 16.54 11.68 55 405250 1893 34549733
Hot flush 16.53 11.68 298 405007 17768 34533858
Ankle deformity 16.49 11.68 17 405288 224 34551402
Osteomyelitis blastomyces 16.44 11.68 7 405298 15 34551611
Orbital apex syndrome 16.44 11.68 7 405298 15 34551611
Systemic lupus erythematosus 16.44 11.68 86 405219 3638 34547988
Torsade de pointes 16.43 11.68 37 405268 7172 34544454
Anhedonia 16.43 11.68 40 405265 7545 34544081
Sinus node dysfunction 16.43 11.68 15 405290 4234 34547392
Granuloma 16.42 11.68 78 405227 3173 34548453
Kidney infection 16.39 11.68 113 405192 5281 34546345
Viraemia 16.39 11.68 41 405264 1197 34550429
Forced vital capacity decreased 16.35 11.68 31 405274 745 34550881
Drug resistance 16.34 11.68 405 404900 25522 34526104
Pneumonia escherichia 16.34 11.68 23 405282 427 34551199
Paraesthesia 16.29 11.68 594 404711 63578 34488048
Lung abscess 16.26 11.68 68 405237 2617 34549009
Haemorrhage intracranial 16.26 11.68 113 405192 15833 34535793
Infective uveitis 16.26 11.68 6 405299 7 34551619
Total lung capacity abnormal 16.23 11.68 14 405291 145 34551481
Oral candidiasis 16.18 11.68 213 405092 11897 34539729
Mediastinitis 16.17 11.68 29 405276 667 34550959
Necrotising herpetic retinopathy 16.14 11.68 7 405298 16 34551610
Choriomeningitis lymphocytic 16.04 11.68 8 405297 28 34551598
Knee arthroplasty 16.02 11.68 144 405161 7300 34544326
Anger 15.99 11.68 77 405228 11807 34539819
Weight fluctuation 15.98 11.68 109 405196 5076 34546550
Drug use disorder 15.96 11.68 15 405290 4176 34547450
Pulmonary tuberculosis 15.90 11.68 102 405203 4652 34546974
Exposure via ingestion 15.89 11.68 3 405302 2178 34549448
Bordetella infection 15.89 11.68 12 405293 101 34551525
Chronic graft versus host disease oral 15.83 11.68 13 405292 125 34551501
Enteritis 15.77 11.68 154 405151 7988 34543638
Muscle swelling 15.77 11.68 21 405284 369 34551257
Myasthenia gravis crisis 15.70 11.68 27 405278 600 34551026
Malignant melanoma 15.66 11.68 153 405152 7937 34543689
Gastrointestinal mucormycosis 15.65 11.68 15 405290 180 34551446
Swollen tongue 15.64 11.68 102 405203 14503 34537123
Sudden cardiac death 15.62 11.68 12 405293 3689 34547937
Prescription drug used without a prescription 15.62 11.68 3 405302 2151 34549475
Blood triglycerides increased 15.61 11.68 98 405207 14061 34537565
Coronary artery stenosis 15.59 11.68 58 405247 9558 34542068
Ventricular arrhythmia 15.56 11.68 25 405280 5503 34546123
C-reactive protein abnormal 15.55 11.68 162 405143 8548 34543078
Adrenal insufficiency 15.54 11.68 239 405066 13808 34537818
Ileal stenosis 15.49 11.68 43 405262 1338 34550288
Prophylaxis against transplant rejection 15.46 11.68 9 405296 46 34551580
Chromoblastomycosis 15.46 11.68 9 405296 46 34551580
Retroperitoneal lymphadenopathy 15.44 11.68 32 405273 822 34550804
Device adhesion issue 15.43 11.68 6 405299 2698 34548928
Rabies 15.42 11.68 6 405299 9 34551617
Symptom masked 15.39 11.68 27 405278 610 34551016
Maternal drugs affecting foetus 15.33 11.68 14 405291 3951 34547675
Transitional cell carcinoma 15.32 11.68 58 405247 2131 34549495
Cardiac perforation 15.31 11.68 11 405294 85 34551541
Diverticulitis intestinal perforated 15.31 11.68 11 405294 85 34551541
Phospholipidosis 15.31 11.68 9 405296 47 34551579
Gastric haemorrhage 15.30 11.68 64 405241 10197 34541429
Actinic keratosis 15.28 11.68 98 405207 4469 34547157
Renal vein thrombosis 15.28 11.68 14 405291 158 34551468
Subdural haemorrhage 15.28 11.68 9 405296 3182 34548444
Retinitis 15.27 11.68 21 405284 381 34551245
Coordination abnormal 15.27 11.68 42 405263 7602 34544024
Sebaceous adenoma 15.25 11.68 8 405297 32 34551594
Gait disturbance 15.25 11.68 819 404486 84321 34467305
Postoperative wound infection 15.20 11.68 102 405203 4724 34546902
Anal fistula 15.18 11.68 111 405194 5288 34546338
Fear of injection 15.17 11.68 46 405259 1506 34550120
Morganella infection 15.12 11.68 24 405281 498 34551128
Enterobacter infection 15.08 11.68 62 405243 2368 34549258
Dermatitis atopic 15.08 11.68 110 405195 5237 34546389
Activated partial thromboplastin time prolonged 15.06 11.68 51 405254 8644 34542982
Salmonellosis 15.06 11.68 35 405270 974 34550652
Acute lung injury 14.99 11.68 45 405260 1465 34550161
Polymyalgia rheumatica 14.99 11.68 45 405260 1465 34550161
Dysmorphism 14.97 11.68 9 405296 3147 34548479
Diverticular perforation 14.95 11.68 79 405226 3355 34548271
Blood glucose decreased 14.92 11.68 91 405214 13146 34538480
Factor V Leiden mutation 14.91 11.68 11 405294 89 34551537
Skin ulcer 14.90 11.68 350 404955 21866 34529760
Dry skin 14.87 11.68 264 405041 31023 34520603
Diabetic neuropathy 14.87 11.68 16 405289 4181 34547445
Renal tubular necrosis 14.83 11.68 260 405045 15420 34536206
Human herpes virus 8 test positive 14.82 11.68 7 405298 21 34551605
Inadequate analgesia 14.80 11.68 8 405297 2967 34548659
Therapeutic product effect variable 14.78 11.68 5 405300 2451 34549175
Disseminated trichosporonosis 14.74 11.68 9 405296 51 34551575
Alcohol poisoning 14.73 11.68 12 405293 3581 34548045
T-cell prolymphocytic leukaemia 14.60 11.68 9 405296 52 34551574
Antisynthetase syndrome 14.59 11.68 10 405295 71 34551555
Chronic granulomatous disease 14.59 11.68 7 405298 22 34551604
Nystagmus 14.56 11.68 20 405285 4695 34546931
Intestinal stenosis 14.54 11.68 57 405248 2129 34549497
Staphylococcal bacteraemia 14.53 11.68 156 405149 8296 34543330
Intestinal resection 14.51 11.68 49 405256 1700 34549926
Metastases to muscle 14.50 11.68 16 405289 229 34551397
Logorrhoea 14.49 11.68 5 405300 2421 34549205
Blood stem cell transplant failure 14.49 11.68 21 405284 401 34551225
T-cell type acute leukaemia 14.48 11.68 12 405293 117 34551509
Perirectal abscess 14.47 11.68 48 405257 1650 34549976
Atypical mycobacterial infection 14.46 11.68 32 405273 861 34550765
Electrocardiogram ST segment elevation 14.45 11.68 24 405281 5214 34546412
Disorder of orbit 14.43 11.68 11 405294 94 34551532
Graft versus host disease in liver 14.42 11.68 40 405265 1244 34550382
Rheumatoid lung 14.41 11.68 33 405272 909 34550717
Respiratory tract congestion 14.38 11.68 121 405184 6018 34545608
Underdose 14.37 11.68 97 405208 13683 34537943
Rhinitis 14.37 11.68 124 405181 6214 34545412
Respiratory fume inhalation disorder 14.36 11.68 6 405299 12 34551614
Decubitus ulcer 14.34 11.68 54 405251 8867 34542759
Coronary arterial stent insertion 14.34 11.68 16 405289 4113 34547513
Enterocolonic fistula 14.34 11.68 11 405294 95 34551531
Seasonal allergy 14.31 11.68 129 405176 6546 34545080
Dialysis 14.29 11.68 74 405231 11134 34540492
Inspiratory capacity abnormal 14.24 11.68 12 405293 120 34551506
Arteriospasm coronary 14.23 11.68 11 405294 3371 34548255
Refractory cytopenia with unilineage dysplasia 14.22 11.68 24 405281 525 34551101
Skin squamous cell carcinoma metastatic 14.20 11.68 9 405296 55 34551571
Fluoride increased 14.20 11.68 9 405296 55 34551571
Limb deformity 14.18 11.68 25 405280 567 34551059
Colour blindness acquired 14.16 11.68 10 405295 75 34551551
Panniculitis 14.09 11.68 53 405252 1941 34549685
Chronic spontaneous urticaria 14.09 11.68 12 405293 122 34551504
Pyomyositis 14.07 11.68 15 405290 206 34551420
Cutaneous tuberculosis 14.07 11.68 11 405294 98 34551528
Abscess limb 14.02 11.68 79 405226 3438 34548188
Bacterial disease carrier 14.02 11.68 23 405282 491 34551135
Loss of libido 14.02 11.68 6 405299 2546 34549080
Hypoaesthesia 14.01 11.68 576 404729 60868 34490758
Emphysematous cystitis 13.98 11.68 11 405294 99 34551527
Pyelonephritis acute 13.95 11.68 54 405251 2005 34549621
Device issue 13.95 11.68 62 405243 9715 34541911
Feeling abnormal 13.95 11.68 595 404710 62640 34488986
Viral vasculitis 13.95 11.68 10 405295 77 34551549
Thrombocytopenia 13.94 11.68 1592 403713 154655 34396971
Blood stem cell harvest failure 13.93 11.68 7 405298 25 34551601
Meningoencephalitis amoebic 13.93 11.68 12 405293 124 34551502
Diaphragm muscle weakness 13.89 11.68 13 405292 151 34551475
Thirst 13.89 11.68 46 405259 7849 34543777
Small intestinal obstruction 13.88 11.68 246 405059 14620 34537006
Erysipelothrix infection 13.88 11.68 4 405301 0 34551626
Metastases to pituitary gland 13.88 11.68 4 405301 0 34551626
Salivary duct obstruction 13.88 11.68 4 405301 0 34551626
Trichosporon infection 13.86 11.68 28 405277 706 34550920
Necrotising soft tissue infection 13.85 11.68 10 405295 78 34551548
Ulcer 13.79 11.68 160 405145 8675 34542951
Bundle branch block right 13.77 11.68 43 405262 7473 34544153
Nephritis haemorrhagic 13.75 11.68 6 405299 14 34551612
Biliary hamartoma 13.75 11.68 6 405299 14 34551612
Disseminated mycobacterium avium complex infection 13.74 11.68 10 405295 79 34551547
Pneumonia klebsiella 13.74 11.68 75 405230 3225 34548401
Splenic marginal zone lymphoma 13.73 11.68 7 405298 26 34551600
Vertebroplasty 13.73 11.68 7 405298 26 34551600
Hip arthroplasty 13.71 11.68 94 405211 4385 34547241
Elbow operation 13.70 11.68 12 405293 127 34551499
Application site erythema 13.64 11.68 5 405300 2331 34549295
Pneumatosis intestinalis 13.64 11.68 85 405220 3838 34547788
Eye abscess 13.63 11.68 13 405292 155 34551471
Abdominal distension 13.62 11.68 547 404758 57945 34493681
Pericarditis infective 13.58 11.68 9 405296 60 34551566
Carotid artery aneurysm 13.58 11.68 8 405297 42 34551584
Laryngeal mass 13.53 11.68 7 405298 27 34551599
Chronic graft versus host disease 13.52 11.68 92 405213 4281 34547345
Neurocryptococcosis 13.47 11.68 6 405299 15 34551611
Faeces soft 13.46 11.68 78 405227 3430 34548196
Colitis ischaemic 13.37 11.68 35 405270 6440 34545186
Bone marrow reticulin fibrosis 13.37 11.68 13 405292 159 34551467
Hypovolaemic shock 13.36 11.68 40 405265 7045 34544581
Mouth ulceration 13.31 11.68 203 405102 11707 34539919
Diffuse idiopathic skeletal hyperostosis 13.29 11.68 8 405297 44 34551582
Supraventricular tachycardia 13.29 11.68 75 405230 11042 34540584
Vertigo 13.27 11.68 212 405093 25324 34526302
Prostate cancer stage IV 13.24 11.68 6 405299 2462 34549164
Subacute endocarditis 13.24 11.68 9 405296 63 34551563
Chronic myeloid leukaemia 13.22 11.68 56 405249 2168 34549458
Purulent pericarditis 13.20 11.68 6 405299 16 34551610
Gastric ulcer haemorrhage, obstructive 13.20 11.68 6 405299 16 34551610
Infection parasitic 13.20 11.68 12 405293 134 34551492
Histology abnormal 13.19 11.68 17 405288 289 34551337
Chronic graft versus host disease in liver 13.15 11.68 21 405284 438 34551188
Thyroid gland abscess 13.12 11.68 9 405296 64 34551562
Graft complication 13.10 11.68 19 405286 363 34551263
Affect lability 13.09 11.68 14 405291 3669 34547957
Acarodermatitis 13.09 11.68 20 405285 401 34551225
Cholangitis 13.07 11.68 54 405251 8635 34542991
Atypical mycobacterial pneumonia 13.06 11.68 12 405293 136 34551490
Sensory disturbance 13.05 11.68 33 405272 6144 34545482
Rhinovirus infection 13.03 11.68 90 405215 4209 34547417
Disseminated varicella zoster vaccine virus infection 13.01 11.68 8 405297 46 34551580
Ophthalmic herpes zoster 13.01 11.68 31 405274 877 34550749
Liver function test abnormal 12.99 11.68 268 405037 30806 34520820
Acute erythroid leukaemia 12.99 11.68 13 405292 165 34551461
Renal cancer 12.97 11.68 46 405259 7689 34543937
Lip ulceration 12.96 11.68 28 405277 741 34550885
Renal cell carcinoma stage I 12.95 11.68 6 405299 17 34551609
Traumatic lung injury 12.94 11.68 38 405267 1222 34550404
Cholestasis 12.93 11.68 227 405078 26721 34524905
Fibrosis 12.92 11.68 61 405244 2475 34549151
Bacteroides infection 12.92 11.68 12 405293 138 34551488
Optic neuropathy 12.88 11.68 51 405254 1914 34549712
Hepatitis viral 12.88 11.68 24 405281 569 34551057
Cerebral haematoma 12.87 11.68 21 405284 4594 34547032
Drug tolerance decreased 12.85 11.68 51 405254 1916 34549710
Clonus 12.82 11.68 8 405297 2742 34548884
Product complaint 12.81 11.68 31 405274 5859 34545767
Ossicle disorder 12.80 11.68 7 405298 31 34551595
Tender joint count increased 12.76 11.68 14 405291 199 34551427
Retroperitoneal mass 12.71 11.68 10 405295 90 34551536
Glomerulonephritis 12.70 11.68 51 405254 1927 34549699
Ileus 12.69 11.68 126 405179 16373 34535253
Cardiac sarcoidosis 12.69 11.68 9 405296 68 34551558
Stupor 12.69 11.68 9 405296 2882 34548744
Illness 12.68 11.68 224 405081 13305 34538321
Chronic hepatitis 12.67 11.68 26 405279 663 34550963
Meningitis haemophilus 12.66 11.68 5 405300 8 34551618
Visual impairment 12.64 11.68 317 404988 35485 34516141
Aspiration 12.63 11.68 86 405219 12108 34539518
Venous angioma of brain 12.63 11.68 7 405298 32 34551594
Immune system disorder 12.62 11.68 102 405203 5013 34546613
Device malfunction 12.62 11.68 70 405235 10351 34541275
Haemoglobin decreased 12.60 11.68 1217 404088 119555 34432071
Chemical peritonitis 12.59 11.68 11 405294 116 34551510
Alveolar osteitis 12.53 11.68 10 405295 92 34551534
International normalised ratio decreased 12.53 11.68 21 405284 4546 34547080
Pulmonary cavitation 12.52 11.68 31 405274 899 34550727
Pneumonitis 12.52 11.68 496 404809 33382 34518244
Skin plaque 12.48 11.68 94 405211 4520 34547106
Diverticulitis 12.47 11.68 312 404993 19692 34531934
Refractory cancer 12.45 11.68 12 405293 145 34551481
Jaundice 12.45 11.68 278 405027 31604 34520022
Rhonchi 12.44 11.68 50 405255 1890 34549736
Chronic myelomonocytic leukaemia 12.41 11.68 25 405280 629 34550997
Hepatic failure 12.40 11.68 305 405000 34226 34517400
Respiratory rate increased 12.39 11.68 172 405133 9722 34541904
Pseudomonal bacteraemia 12.38 11.68 41 405264 1408 34550218
Scrotal ulcer 12.36 11.68 21 405284 462 34551164
Road traffic accident 12.31 11.68 136 405169 17314 34534312
Venoocclusive liver disease 12.30 11.68 49 405256 7917 34543709
Rhinitis perennial 12.30 11.68 17 405288 310 34551316
Incision site pain 12.29 11.68 48 405257 1790 34549836
Drug dependence 12.27 11.68 202 405103 24015 34527611
Coagulation factor deficiency 12.26 11.68 12 405293 148 34551478
Hyperthyroidism 12.24 11.68 72 405233 10494 34541132
Pneumopericardium 12.23 11.68 11 405294 121 34551505
Decreased activity 12.22 11.68 90 405215 4297 34547329
Glomerulonephritis membranoproliferative 12.22 11.68 20 405285 426 34551200
Needle issue 12.22 11.68 34 405271 6131 34545495
Inappropriate antidiuretic hormone secretion 12.21 11.68 92 405213 12661 34538965
Enuresis 12.20 11.68 6 405299 2347 34549279
Osteoporotic fracture 12.19 11.68 34 405271 1061 34550565
Atrioventricular block complete 12.18 11.68 61 405244 9258 34542368
Myasthenic syndrome 12.17 11.68 22 405283 509 34551117
Neurosarcoidosis 12.17 11.68 13 405292 179 34551447
Treatment noncompliance 12.15 11.68 241 405064 27859 34523767
Renal transplant 12.13 11.68 48 405257 1801 34549825
Ocular discomfort 12.12 11.68 53 405252 2081 34549545
Herpes dermatitis 12.11 11.68 8 405297 53 34551573
Hepatitis C RNA increased 12.11 11.68 16 405289 279 34551347
Glomerulonephritis minimal lesion 12.11 11.68 21 405284 470 34551156
Oesophageal carcinoma 12.10 11.68 61 405244 9243 34542383
Eschar 12.08 11.68 26 405279 686 34550940
Orbital myositis 12.08 11.68 11 405294 123 34551503
Depression suicidal 12.08 11.68 7 405298 2498 34549128
Papilloma viral infection 12.07 11.68 21 405284 471 34551155
Mycobacterium kansasii infection 12.06 11.68 17 405288 316 34551310
Injection site pain 12.05 11.68 352 404953 38653 34512973
Face oedema 12.04 11.68 81 405224 11435 34540191
Infusion site extravasation 12.04 11.68 89 405216 4255 34547371
Kaposi sarcoma inflammatory cytokine syndrome 12.03 11.68 6 405299 21 34551605
Organising pneumonia 12.03 11.68 114 405191 5865 34545761
Dysuria 12.01 11.68 232 405073 26920 34524706
Intestinal fistula 11.98 11.68 32 405273 973 34550653
Meningitis noninfective 11.97 11.68 5 405300 10 34551616
Musculoskeletal disorder 11.85 11.68 117 405188 6087 34545539
Epstein Barr virus positive mucocutaneous ulcer 11.85 11.68 18 405287 359 34551267
Keloid scar 11.84 11.68 7 405298 37 34551589
Necrotising fasciitis fungal 11.83 11.68 6 405299 22 34551604
Cutaneous T-cell lymphoma 11.81 11.68 42 405263 1496 34550130
Ischaemic stroke 11.80 11.68 145 405160 18105 34533521
Bone density decreased 11.80 11.68 49 405256 1880 34549746
Herpes simplex encephalitis 11.79 11.68 17 405288 323 34551303
Terminal insomnia 11.79 11.68 23 405282 565 34551061
Splenic lesion 11.77 11.68 15 405290 252 34551374
Large intestine anastomosis 11.76 11.68 8 405297 56 34551570
Blood pressure diastolic decreased 11.76 11.68 159 405146 8935 34542691
Eye infection fungal 11.74 11.68 18 405287 362 34551264
Peak expiratory flow rate decreased 11.74 11.68 11 405294 128 34551498
Heparin-induced thrombocytopenia 11.74 11.68 30 405275 5565 34546061
Graft thrombosis 11.73 11.68 16 405289 288 34551338
Lupus-like syndrome 11.72 11.68 63 405242 2693 34548933
Sickle cell anaemia with crisis 11.72 11.68 18 405287 4035 34547591
Respiratory tract infection fungal 11.72 11.68 26 405279 701 34550925
Diabetic metabolic decompensation 11.71 11.68 46 405259 1720 34549906
Mucocutaneous leishmaniasis 11.71 11.68 9 405296 78 34551548
Vascular shunt 11.70 11.68 7 405298 38 34551588

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2353.84 11.14 250 1051055 245517 78447566
Drug ineffective 2027.00 11.14 22429 1028876 1058484 77634599
Rheumatoid arthritis 1571.17 11.14 6167 1045138 202303 78490780
Drug abuse 1430.18 11.14 218 1051087 162473 78530610
Off label use 1410.64 11.14 18178 1033127 889037 77804046
Toxicity to various agents 1355.01 11.14 2167 1049138 419373 78273710
Colitis ulcerative 1216.84 11.14 1868 1049437 32874 78660209
Condition aggravated 1078.32 11.14 10709 1040596 490415 78202668
Death 1051.23 11.14 3884 1047421 562630 78130453
Asthma 954.13 11.14 3918 1047387 131177 78561906
Overdose 949.95 11.14 630 1050675 183576 78509507
Intentional overdose 935.62 11.14 140 1051165 105820 78587263
Post transplant lymphoproliferative disorder 830.55 11.14 885 1050420 10579 78682504
Therapeutic product effect incomplete 810.70 11.14 3858 1047447 137787 78555296
Joint swelling 756.36 11.14 6439 1044866 282207 78410876
Arthralgia 738.33 11.14 11097 1040208 560706 78132377
Bradycardia 724.29 11.14 445 1050860 135112 78557971
Treatment failure 715.98 11.14 4264 1047041 166222 78526861
Nocardiosis 676.28 11.14 577 1050728 5102 78687981
Intentional product use issue 670.76 11.14 3854 1047451 148258 78544825
Wheezing 662.66 11.14 3171 1048134 113493 78579590
Acute kidney injury 593.50 11.14 4209 1047096 515195 78177888
Hypotension 590.52 11.14 3397 1047908 436920 78256163
Electrocardiogram QT prolonged 582.05 11.14 231 1051074 90155 78602928
Hyponatraemia 573.42 11.14 911 1050394 176937 78516146
Depressed level of consciousness 562.86 11.14 285 1051020 96367 78596716
Product use in unapproved indication 560.11 11.14 5398 1045907 244961 78448122
Loss of personal independence in daily activities 540.25 11.14 2729 1048576 99851 78593232
Pneumocystis jirovecii pneumonia 534.19 11.14 1266 1050039 31242 78661841
Obstructive airways disorder 532.04 11.14 1239 1050066 30220 78662863
Transplant rejection 531.74 11.14 935 1050370 18502 78674581
Suicide attempt 525.79 11.14 217 1051088 82715 78610368
Fall 517.98 11.14 4033 1047272 483596 78209487
Drug interaction 514.15 11.14 3284 1048021 411899 78281184
Constipation 500.15 11.14 1977 1049328 281073 78412010
Cardio-respiratory arrest 497.52 11.14 419 1050886 108091 78584992
Polyomavirus-associated nephropathy 479.37 11.14 474 1050831 5153 78687930
Aspergillus infection 472.36 11.14 881 1050424 18280 78674803
Therapeutic product effect decreased 465.94 11.14 3725 1047580 160138 78532945
Cytomegalovirus infection 459.19 11.14 1421 1049884 41223 78651860
Hypoglycaemia 458.81 11.14 398 1050907 101196 78591887
Somnolence 438.97 11.14 1643 1049662 237338 78455745
Rhabdomyolysis 437.34 11.14 428 1050877 102703 78590380
Weight increased 437.05 11.14 5581 1045724 271805 78421278
Arthropathy 431.13 11.14 3889 1047416 173222 78519861
Seizure 425.63 11.14 1185 1050120 187649 78505434
Histoplasmosis disseminated 425.47 11.14 306 1050999 2047 78691036
Full blood count abnormal 416.77 11.14 1328 1049977 39146 78653937
Blood pressure fluctuation 414.20 11.14 1870 1049435 65275 78627808
Cardiac arrest 409.76 11.14 1051 1050254 171045 78522038
Drug intolerance 399.62 11.14 5275 1046030 258844 78434239
Strongyloidiasis 396.14 11.14 362 1050943 3536 78689547
Dizziness 394.83 11.14 4741 1046564 521700 78171383
Kidney transplant rejection 393.07 11.14 575 1050730 9671 78683412
Vomiting 385.56 11.14 6317 1044988 659511 78033572
Sleep disorder due to a general medical condition 380.50 11.14 679 1050626 13598 78679485
Contraindicated product administered 379.69 11.14 3452 1047853 154086 78538997
Loss of consciousness 371.00 11.14 1064 1050241 166879 78526204
Productive cough 362.66 11.14 2197 1049108 86134 78606949
Synovitis 357.21 11.14 3291 1048014 147443 78545640
Hepatic function abnormal 342.89 11.14 276 1051029 72831 78620252
Anaemia 342.22 11.14 3985 1047320 441030 78252053
Intentional product misuse 337.40 11.14 456 1050849 94709 78598374
Disease recurrence 335.69 11.14 1310 1049995 42799 78650284
Sedation 333.47 11.14 133 1051172 51762 78641321
Inappropriate schedule of product administration 330.10 11.14 2944 1048361 130684 78562399
Epstein-Barr virus infection 329.65 11.14 642 1050663 13774 78679309
Serotonin syndrome 324.66 11.14 95 1051210 44932 78648151
Respiratory arrest 322.80 11.14 178 1051127 57372 78635711
Dehydration 322.45 11.14 1933 1049372 246254 78446829
Nausea 318.94 11.14 9905 1041400 947291 77745792
Frequent bowel movements 312.17 11.14 978 1050327 28561 78664522
Agitation 310.76 11.14 522 1050783 99193 78593890
Systemic lupus erythematosus 310.59 11.14 2691 1048614 118458 78574625
Lactic acidosis 305.27 11.14 286 1051019 70073 78623010
Confusional state 300.53 11.14 2711 1048594 315286 78377797
Syncope 298.86 11.14 1282 1050023 178167 78514916
Cryptococcosis 293.41 11.14 292 1051013 3201 78689882
Osteoporosis 290.71 11.14 1448 1049857 52664 78640419
Cytomegalovirus viraemia 289.56 11.14 568 1050737 12253 78680830
Orthostatic hypotension 282.74 11.14 197 1051108 55967 78637116
Hallucination 282.14 11.14 433 1050872 85312 78607771
Musculoskeletal stiffness 280.37 11.14 3533 1047772 171475 78521608
Hypokalaemia 278.42 11.14 969 1050336 143071 78550012
Drug level below therapeutic 276.37 11.14 477 1050828 9293 78683790
Infusion related reaction 274.74 11.14 4413 1046892 225824 78467259
Phaeohyphomycosis 273.95 11.14 180 1051125 1017 78692066
Coma 273.86 11.14 572 1050733 100077 78593006
Cognitive disorder 273.11 11.14 311 1050994 69615 78623468
Cough 271.34 11.14 6539 1044766 360250 78332833
Sputum discoloured 270.74 11.14 763 1050542 20980 78672103
Arthritis 266.46 11.14 2497 1048808 112383 78580700
Aggression 265.58 11.14 172 1051133 50786 78642297
Histoplasmosis 264.82 11.14 232 1051073 2133 78690950
Pain 264.03 11.14 11567 1039738 692235 78000848
Swelling 262.41 11.14 4164 1047141 212547 78480536
White blood cell count decreased 260.86 11.14 1436 1049869 186852 78506231
Intentional self-injury 259.69 11.14 55 1051250 32364 78660719
Rebound effect 255.01 11.14 390 1050915 6836 78686247
Blood creatine phosphokinase increased 254.81 11.14 297 1051008 65793 78627290
Forced expiratory volume decreased 253.88 11.14 406 1050899 7408 78685675
Hand deformity 252.25 11.14 2281 1049024 101638 78591445
Hyperkalaemia 251.68 11.14 726 1050579 113672 78579411
Neuroleptic malignant syndrome 251.21 11.14 33 1051272 27526 78665557
Myocardial infarction 247.09 11.14 1419 1049886 182710 78510373
International normalised ratio increased 245.52 11.14 464 1050841 84257 78608826
Faecal calprotectin increased 240.71 11.14 330 1050975 5211 78687872
Suicidal ideation 237.52 11.14 400 1050905 75940 78617143
Nasopharyngitis 236.06 11.14 4678 1046627 249203 78443880
Device expulsion 233.27 11.14 32 1051273 25829 78667254
Decreased appetite 231.65 11.14 3150 1048155 339268 78353815
Sinusitis 231.60 11.14 3743 1047562 191758 78501325
Neutrophil count decreased 228.83 11.14 567 1050738 93392 78599691
Pemphigus 226.69 11.14 2156 1049149 97426 78595657
Respiratory depression 225.20 11.14 45 1051260 27585 78665498
Platelet count decreased 224.32 11.14 1572 1049733 193092 78499991
Tachycardia 221.17 11.14 1403 1049902 176365 78516718
Infection 221.10 11.14 4443 1046862 237269 78455814
Unresponsive to stimuli 219.08 11.14 247 1051058 55541 78637542
Therapeutic response shortened 214.75 11.14 574 1050731 15289 78677794
Product use issue 213.43 11.14 3920 1047385 205902 78487181
Balance disorder 213.36 11.14 633 1050672 98224 78594859
Inflammation 213.01 11.14 2029 1049276 91724 78601359
Brain abscess 212.96 11.14 293 1051012 4643 78688440
Palmar-plantar erythrodysaesthesia syndrome 212.75 11.14 85 1051220 33049 78660034
Cardiac failure 211.13 11.14 1187 1050118 153655 78539428
Gastrointestinal haemorrhage 207.09 11.14 1122 1050183 146597 78546486
Poisoning 204.23 11.14 42 1051263 25230 78667853
Cardiac failure congestive 202.74 11.14 1076 1050229 141326 78551757
Bronchiectasis 200.65 11.14 701 1050604 21685 78671398
Circulatory collapse 200.61 11.14 124 1051181 37544 78655539
Peripheral swelling 197.78 11.14 4802 1046503 264815 78428268
COVID-19 195.84 11.14 3043 1048262 154631 78538452
Malignant neoplasm progression 193.91 11.14 1027 1050278 134963 78558120
Altered state of consciousness 193.80 11.14 175 1051130 43647 78649436
Metabolic acidosis 193.27 11.14 508 1050797 82021 78611062
Blood pressure systolic increased 188.69 11.14 1520 1049785 65466 78627617
Cerebrovascular accident 188.38 11.14 1235 1050070 154057 78539026
Dysarthria 187.58 11.14 380 1050925 67242 78625841
Sedation complication 186.81 11.14 4 1051301 15665 78677418
Varicella zoster virus infection 186.19 11.14 260 1051045 4181 78688902
Trichodysplasia spinulosa 185.90 11.14 121 1051184 671 78692412
Tremor 184.61 11.14 1397 1049908 168686 78524397
Dyskinesia 181.59 11.14 193 1051112 44580 78648503
Cushingoid 181.37 11.14 394 1050911 9158 78683925
Diffuse large B-cell lymphoma recurrent 180.41 11.14 249 1051056 3958 78689125
Mucormycosis 179.03 11.14 365 1050940 8104 78684979
Drug level decreased 178.92 11.14 505 1050800 13897 78679186
Epistaxis 178.13 11.14 809 1050496 110706 78582377
Malacoplakia 176.41 11.14 108 1051197 528 78692555
Complications of transplanted kidney 176.40 11.14 308 1050997 6058 78687025
Drug withdrawal syndrome 174.45 11.14 122 1051183 34596 78658487
Haematemesis 172.81 11.14 263 1051042 52001 78641082
BK virus infection 172.74 11.14 368 1050937 8436 78684647
Cytomegalovirus colitis 172.63 11.14 258 1051047 4427 78688656
Blastomycosis 171.60 11.14 111 1051194 608 78692475
Acute myocardial infarction 170.07 11.14 488 1050817 76548 78616535
Angioedema 166.87 11.14 483 1050822 75552 78617531
Smooth muscle cell neoplasm 166.87 11.14 122 1051183 840 78692243
Hepatitis B reactivation 165.99 11.14 293 1051012 5815 78687268
Sopor 165.86 11.14 116 1051189 32894 78660189
Cerebral infarction 165.81 11.14 215 1051090 45461 78647622
Hypomagnesaemia 165.01 11.14 226 1051079 46685 78646398
Hyperhidrosis 164.06 11.14 1245 1050060 150247 78542836
Therapeutic reaction time decreased 163.52 11.14 216 1051089 3285 78689798
Red blood cell sedimentation rate increased 163.38 11.14 1102 1050203 44840 78648243
Melaena 160.65 11.14 352 1050953 60538 78632545
General physical health deterioration 160.43 11.14 2606 1048699 272632 78420451
Glossodynia 159.81 11.14 2073 1049232 101264 78591819
Poisoning deliberate 159.14 11.14 28 1051277 18800 78674283
Chronic allograft nephropathy 158.65 11.14 151 1051154 1560 78691523
Bronchopulmonary aspergillosis 158.29 11.14 648 1050657 21646 78671437
Renal transplant failure 157.57 11.14 158 1051147 1749 78691334
Disturbance in attention 156.35 11.14 268 1051037 50533 78642550
Mycobacterial infection 155.65 11.14 216 1051089 3452 78689631
Mycobacterium avium complex infection 153.57 11.14 242 1051063 4358 78688725
Labelled drug-drug interaction medication error 152.92 11.14 87 1051218 27563 78665520
Anti-cyclic citrullinated peptide antibody positive 152.61 11.14 1723 1049582 81420 78611663
Wrong technique in product usage process 151.60 11.14 484 1050821 73391 78619692
Drug reaction with eosinophilia and systemic symptoms 151.53 11.14 394 1050911 63850 78629233
Restlessness 150.80 11.14 237 1051068 46255 78646828
Multiple sclerosis relapse 150.18 11.14 238 1051067 46295 78646788
Delirium 149.92 11.14 590 1050715 84037 78609046
Herpes zoster 149.32 11.14 1880 1049425 91203 78601880
Ascites 148.89 11.14 504 1050801 75058 78618025
Weight decreased 148.39 11.14 5907 1045398 349291 78343792
Ventricular fibrillation 147.86 11.14 122 1051183 31804 78661279
Extrapyramidal disorder 145.90 11.14 58 1051247 22621 78670462
Nasal polyps 144.61 11.14 307 1050998 7020 78686063
Aspartate aminotransferase increased 144.23 11.14 1152 1050153 137489 78555594
Product prescribing error 143.87 11.14 230 1051075 44583 78648500
Mucous stools 142.06 11.14 249 1051056 4913 78688170
Blood pressure increased 141.20 11.14 3718 1047587 207642 78485441
Immunosuppressant drug level increased 140.17 11.14 344 1050961 8683 78684400
Haemophagocytic lymphohistiocytosis 139.76 11.14 615 1050690 21222 78671861
Urinary retention 139.23 11.14 340 1050965 56290 78636793
Disorientation 139.06 11.14 397 1050908 62379 78630704
Blood calcium decreased 138.41 11.14 129 1051176 31690 78661393
Nasal congestion 138.06 11.14 1581 1049724 74971 78618112
Focal segmental glomerulosclerosis 137.10 11.14 193 1051112 3128 78689955
Pericarditis 136.05 11.14 2029 1049276 102207 78590876
Epstein-Barr viraemia 135.18 11.14 156 1051149 2049 78691034
Coronary artery disease 134.32 11.14 429 1050876 65045 78628038
Defaecation urgency 133.93 11.14 260 1051045 5564 78687519
Steroid diabetes 133.39 11.14 196 1051109 3310 78689773
Vaccination failure 132.36 11.14 142 1051163 1711 78691372
West Nile viral infection 132.14 11.14 108 1051197 894 78692189
Accidental overdose 131.03 11.14 199 1051106 39382 78653701
Muscle rigidity 130.96 11.14 49 1051256 19833 78673250
Gamma-glutamyltransferase increased 130.76 11.14 333 1050972 54347 78638736
Subdural haematoma 130.29 11.14 133 1051172 31301 78661782
Lethargy 130.25 11.14 589 1050716 80703 78612380
Alanine aminotransferase increased 130.03 11.14 1442 1049863 161128 78531955
Sensitivity to weather change 129.60 11.14 311 1050994 7736 78685347
Dystonia 129.26 11.14 60 1051245 21339 78671744
Meningitis cryptococcal 129.08 11.14 193 1051112 3313 78689770
Human herpesvirus 8 infection 127.31 11.14 115 1051190 1105 78691978
Cerebral haemorrhage 126.81 11.14 366 1050939 57307 78635776
Haematochezia 126.73 11.14 1737 1049568 85908 78607175
Sinus bradycardia 126.48 11.14 89 1051216 25158 78667925
Miosis 126.02 11.14 27 1051278 15762 78677321
Blood alkaline phosphatase increased 125.87 11.14 424 1050881 63240 78629843
Steroid dependence 125.52 11.14 164 1051141 2466 78690617
Septic shock 125.37 11.14 2296 1049009 120505 78572578
Epidermodysplasia verruciformis 124.91 11.14 72 1051233 308 78692775
Oedema peripheral 124.71 11.14 2459 1048846 249829 78443254
Therapy partial responder 124.57 11.14 507 1050798 16890 78676193
Infection reactivation 124.20 11.14 164 1051141 2493 78690590
Therapeutic response decreased 123.85 11.14 1388 1049917 65465 78627618
Mydriasis 122.20 11.14 40 1051265 17603 78675480
Parkinsonism 121.38 11.14 34 1051271 16550 78676533
Red blood cell sedimentation rate abnormal 121.22 11.14 573 1050732 20390 78672693
Atrial fibrillation 121.17 11.14 1856 1049449 196030 78497053
Palpitations 120.89 11.14 1076 1050229 125534 78567549
Discomfort 120.78 11.14 2327 1048978 123290 78569793
Dysgeusia 120.56 11.14 370 1050935 56807 78636276
Progressive multifocal leukoencephalopathy 120.52 11.14 565 1050740 20035 78673048
Product substitution issue 120.50 11.14 58 1051247 20198 78672885
Stevens-Johnson syndrome 120.18 11.14 207 1051098 38959 78654124
Ill-defined disorder 119.01 11.14 1361 1049944 64514 78628569
Ventricular tachycardia 118.57 11.14 233 1051072 41702 78651381
Heart rate decreased 118.29 11.14 1433 1049872 68883 78624200
Clostridium difficile infection 118.26 11.14 965 1050340 41720 78651363
Blood immunoglobulin E increased 117.88 11.14 248 1051057 5634 78687449
Arrhythmia 117.79 11.14 413 1050892 60859 78632224
Blood bilirubin increased 117.16 11.14 462 1050843 65770 78627313
Posterior reversible encephalopathy syndrome 116.40 11.14 667 1050638 25614 78667469
Gastrointestinal disorder 116.20 11.14 2260 1049045 119945 78573138
Graft loss 116.15 11.14 102 1051203 941 78692142
Hallucination, auditory 116.03 11.14 64 1051241 20629 78672454
Pneumonia aspiration 115.38 11.14 472 1050833 66495 78626588
Creatinine renal clearance decreased 115.21 11.14 53 1051252 18949 78674134
Poor venous access 114.53 11.14 509 1050796 17640 78675443
Substance abuse 113.93 11.14 6 1051299 10520 78682563
Pulmonary nocardiosis 112.72 11.14 111 1051194 1200 78691883
Alternaria infection 112.70 11.14 84 1051221 598 78692485
Cataract 112.03 11.14 1283 1050022 60837 78632246
Dust allergy 112.00 11.14 119 1051186 1417 78691666
JC virus infection 110.45 11.14 190 1051115 3691 78689392
Blood pressure diastolic abnormal 110.40 11.14 524 1050781 18678 78674405
Candida infection 110.26 11.14 872 1050433 37342 78655741
Diffuse large B-cell lymphoma 110.23 11.14 382 1050923 11767 78681316
Bacillary angiomatosis 109.70 11.14 58 1051247 201 78692882
C-reactive protein abnormal 108.95 11.14 1045 1050260 47322 78645761
Diarrhoea 108.70 11.14 10064 1041241 870425 77822658
Suspected suicide 108.57 11.14 8 1051297 10568 78682515
Heart rate increased 108.23 11.14 2213 1049092 118511 78574572
Pseudomonas infection 107.78 11.14 553 1050752 20350 78672733
Abnormal behaviour 107.68 11.14 197 1051108 36224 78656859
Neutropenia 106.70 11.14 2931 1048374 284779 78408304
Mycobacterium chelonae infection 106.28 11.14 146 1051159 2310 78690773
Humoral immune defect 105.76 11.14 68 1051237 368 78692715
Epilepsy 105.50 11.14 239 1051066 40621 78652462
Joint stiffness 105.11 11.14 908 1050397 39922 78653161
Secondary immunodeficiency 105.02 11.14 168 1051137 3066 78690017
Wound 104.91 11.14 2132 1049173 114047 78579036
Renal failure 104.75 11.14 1941 1049364 199027 78494056
Disseminated cryptococcosis 104.54 11.14 125 1051180 1709 78691374
Product monitoring error 103.42 11.14 3 1051302 8903 78684180
Respiratory tract congestion 102.96 11.14 528 1050777 19426 78673657
Impaired quality of life 102.80 11.14 419 1050886 13967 78679116
Product administration error 102.65 11.14 163 1051142 31683 78661400
Hallucination, visual 102.24 11.14 171 1051134 32558 78660525
Renal impairment 101.37 11.14 1466 1049839 156317 78536766
Device difficult to use 100.68 11.14 26 1051279 13359 78679724
Respiratory disorder 100.47 11.14 968 1050337 43888 78649195
Lung transplant rejection 100.11 11.14 112 1051193 1419 78691664
Haematotoxicity 100.02 11.14 438 1050867 15081 78678002
Withdrawal syndrome 99.97 11.14 124 1051181 26730 78666353
Parvovirus B19 infection 99.76 11.14 110 1051195 1370 78691713
Psoriatic arthropathy 98.94 11.14 1511 1049794 76488 78616595
Rheumatoid nodule 98.91 11.14 474 1050831 16964 78676119
Uveitis 98.02 11.14 461 1050844 16369 78676714
American trypanosomiasis 97.59 11.14 60 1051245 296 78692787
Depression 97.39 11.14 2146 1049159 214644 78478439
Lower respiratory tract infection 97.19 11.14 2310 1048995 126910 78566173
Thrombocytopenia 96.88 11.14 2708 1048597 262551 78430532
Amnesia 96.81 11.14 464 1050841 62593 78630490
Diabetes mellitus 96.54 11.14 1511 1049794 76879 78616204
Oropharyngeal pain 95.86 11.14 1998 1049307 107355 78585728
Tardive dyskinesia 95.53 11.14 13 1051292 10558 78682525
Transient ischaemic attack 94.85 11.14 365 1050940 52330 78640753
Myoclonus 94.54 11.14 136 1051169 27524 78665559
Coccidioidomycosis 94.53 11.14 101 1051204 1211 78691872
Akathisia 93.72 11.14 29 1051276 13230 78679853
Toxic epidermal necrolysis 93.63 11.14 289 1051016 44292 78648791
Torsade de pointes 92.95 11.14 71 1051234 19241 78673842
Human ehrlichiosis 92.93 11.14 69 1051236 488 78692595
Diabetic ketoacidosis 92.71 11.14 194 1051111 33928 78659155
Anaphylactic shock 92.57 11.14 211 1051094 35785 78657298
Hypothermia 92.29 11.14 98 1051207 22648 78670435
Fistula 91.77 11.14 376 1050929 12564 78680519
Medication error 90.93 11.14 531 1050774 68111 78624972
Schizophrenia 90.65 11.14 45 1051260 15395 78677688
Rheumatoid factor positive 90.23 11.14 1195 1050110 58644 78634439
Philadelphia positive chronic myeloid leukaemia 90.02 11.14 45 1051260 134 78692949
Upper gastrointestinal haemorrhage 89.96 11.14 264 1051041 41116 78651967
Acute respiratory distress syndrome 89.53 11.14 932 1050373 43135 78649948
Hepatic enzyme increased 89.20 11.14 3091 1048214 179519 78513564
Blood pressure diastolic increased 88.88 11.14 404 1050901 14138 78678945
Breath sounds abnormal 88.87 11.14 432 1050873 15552 78677531
Device dislocation 88.46 11.14 128 1051177 25842 78667241
Bronchial wall thickening 88.25 11.14 139 1051166 2502 78690581
Hypersensitivity 88.09 11.14 4265 1047040 257974 78435109
Blood pressure systolic abnormal 88.03 11.14 455 1050850 16792 78676291
Anal fissure 87.88 11.14 262 1051043 7441 78685642
Epstein-Barr virus associated lymphoproliferative disorder 87.80 11.14 163 1051142 3369 78689714
Legionella infection 87.78 11.14 78 1051227 732 78692351
Delusion 87.42 11.14 84 1051221 20339 78672744
Mobility decreased 87.34 11.14 2169 1049136 120006 78573077
Salivary hypersecretion 87.29 11.14 39 1051266 14185 78678898
Obliterative bronchiolitis 87.17 11.14 149 1051156 2879 78690204
Impaired healing 87.06 11.14 1632 1049673 86023 78607060
Alopecia 85.94 11.14 3801 1047504 227554 78465529
Exposure to toxic agent 85.83 11.14 10 1051295 9148 78683935
Memory impairment 85.82 11.14 1000 1050305 110734 78582349
Abdominal discomfort 85.74 11.14 4085 1047220 246642 78446441
Osteonecrosis 85.60 11.14 702 1050603 30393 78662690
Aphthous ulcer 85.13 11.14 444 1050861 16445 78676638
Therapy non-responder 85.03 11.14 1699 1049606 90606 78602477
Pulmonary mass 84.57 11.14 664 1050641 28370 78664713
Fungal infection 84.37 11.14 882 1050423 40866 78652217
Escherichia infection 84.25 11.14 464 1050841 17553 78675530
Influenza 84.22 11.14 2272 1049033 127334 78565749
Blood pressure diastolic decreased 83.10 11.14 682 1050623 29534 78663549
Muscle spasms 82.43 11.14 1716 1049589 173014 78520069
Rhodococcus infection 82.12 11.14 53 1051252 289 78692794
Myocardial ischaemia 81.89 11.14 131 1051174 25388 78667695
Product quality issue 81.68 11.14 206 1051099 33734 78659349
Paraesthesia 81.61 11.14 1737 1049568 174586 78518497
Blood urea increased 81.49 11.14 348 1050957 48442 78644641
Pulmonary function test abnormal 81.05 11.14 173 1051132 3971 78689112
Accidental exposure to product 81.03 11.14 183 1051122 31139 78661944
Generalised tonic-clonic seizure 80.42 11.14 302 1051003 43608 78649475
Foot deformity 80 11.14 568 1050737 23506 78669577
Cerebral aspergillosis 79.58 11.14 108 1051197 1688 78691395
Bladder cancer 79.36 11.14 84 1051221 19442 78673641
Pulmonary oedema 79.06 11.14 762 1050543 87492 78605591
Nightmare 79.05 11.14 137 1051168 25724 78667359
Disseminated tuberculosis 78.80 11.14 172 1051133 4011 78689072
Atrioventricular block first degree 78.64 11.14 33 1051272 12458 78680625
Immunosuppression 78.48 11.14 356 1050949 12447 78680636
Liver transplant rejection 78.38 11.14 148 1051157 3100 78689983
Psychotic disorder 78.29 11.14 281 1051024 41121 78651962
Scedosporium infection 78.18 11.14 97 1051208 1381 78691702
COVID-19 pneumonia 77.65 11.14 648 1050657 28201 78664882
Transplant dysfunction 77.13 11.14 240 1051065 6981 78686102
Neuropathy peripheral 77.00 11.14 1354 1049951 139951 78553132
Hepatic cytolysis 76.64 11.14 151 1051154 27000 78666083
Sexual dysfunction 76.57 11.14 7 1051298 7756 78685327
Hepatitis B 76.48 11.14 263 1051042 8069 78685014
Sensitisation 76.36 11.14 148 1051157 3163 78689920
Helicobacter infection 76.35 11.14 1318 1049987 68386 78624697
Pneumocystis jirovecii infection 76.30 11.14 137 1051168 2757 78690326
Cardiogenic shock 76.29 11.14 289 1051016 41625 78651458
Renal graft infection 76.17 11.14 61 1051244 489 78692594
Impaired work ability 76.00 11.14 482 1050823 19199 78673884
Rhinorrhoea 75.76 11.14 1417 1049888 74657 78618426
Pneumonia cytomegaloviral 75.72 11.14 188 1051117 4781 78688302
Colectomy 75.61 11.14 149 1051156 3225 78689858
Chest pain 75.25 11.14 3000 1048305 279304 78413779
Disseminated blastomycosis 74.92 11.14 41 1051264 155 78692928
Blood glucose increased 74.62 11.14 1066 1050239 113909 78579174
Listeriosis 74.60 11.14 118 1051187 2132 78690951
Hypocalcaemia 74.53 11.14 371 1050934 49553 78643530
Mycotic allergy 74.49 11.14 96 1051209 1423 78691660
Metastases to liver 74.42 11.14 164 1051141 28150 78664933
Erectile dysfunction 74.37 11.14 51 1051254 14613 78678470
Shock 74.35 11.14 308 1050997 43240 78649843
Ureaplasma infection 74.19 11.14 80 1051225 970 78692113
Sinus pain 74.09 11.14 157 1051148 3585 78689498
Drug specific antibody present 73.77 11.14 224 1051081 6428 78686655
Cytomegalovirus gastrointestinal infection 73.50 11.14 58 1051247 454 78692629
Sleep disorder due to general medical condition, insomnia type 73.40 11.14 888 1050417 42668 78650415
Heart transplant rejection 73.38 11.14 95 1051210 1415 78691668
Blood creatinine increased 73.36 11.14 1522 1049783 153535 78539548
Visceral leishmaniasis 73.17 11.14 82 1051223 1041 78692042
Upper-airway cough syndrome 73.08 11.14 327 1050978 11366 78681717
Delayed graft function 72.78 11.14 150 1051155 3357 78689726
Electrocardiogram abnormal 72.62 11.14 68 1051237 16669 78676414
Panniculitis 72.15 11.14 339 1050966 12032 78681051
Joint injury 72.05 11.14 680 1050625 30655 78662428
Inappropriate antidiuretic hormone secretion 72.00 11.14 149 1051156 26164 78666919
Aphasia 71.66 11.14 344 1050961 46388 78646695
Hypogammaglobulinaemia 71.27 11.14 349 1050956 12602 78680481
Drug effective for unapproved indication 71.22 11.14 207 1051098 5794 78687289
Arthritis bacterial 71.17 11.14 274 1051031 8892 78684191
Herpes simplex 70.38 11.14 333 1050972 11854 78681229
Klebsiella infection 70.29 11.14 400 1050905 15320 78677763
Blood test abnormal 69.80 11.14 436 1050869 17274 78675809
Toxic skin eruption 69.15 11.14 117 1051188 22176 78670907
Human polyomavirus infection 69.07 11.14 79 1051226 1027 78692056
Bradyphrenia 68.79 11.14 27 1051278 10613 78682470
Adenovirus infection 68.47 11.14 256 1051049 8191 78684892
Polymyalgia rheumatica 68.44 11.14 171 1051134 4366 78688717
Osteoporotic fracture 68.42 11.14 164 1051141 4076 78689007
Ataxia 68.33 11.14 142 1051163 24897 78668186
Sporotrichosis 68.31 11.14 33 1051272 89 78692994
Blood sodium decreased 68.13 11.14 218 1051087 33037 78660046
Limb deformity 68.07 11.14 148 1051157 3442 78689641
Euglycaemic diabetic ketoacidosis 67.97 11.14 6 1051299 6838 78686245
Myalgia 67.53 11.14 1896 1049409 183745 78509338
Kidney fibrosis 67.33 11.14 146 1051159 3389 78689694
Polyarthritis 67.28 11.14 329 1050976 11873 78681210
Dementia 67.16 11.14 140 1051165 24519 78668564
Coma scale abnormal 66.94 11.14 16 1051289 8662 78684421
Cyanosis 66.89 11.14 145 1051160 25037 78668046
Drug specific antibody 66.23 11.14 122 1051183 2506 78690577
Dysphagia 66.00 11.14 1172 1050133 120964 78572119
Skin ulcer 66.00 11.14 1042 1050263 53108 78639975
Folliculitis 65.74 11.14 1061 1050244 54319 78638764
Ketoacidosis 65.69 11.14 12 1051293 7842 78685241
Duodenal ulcer perforation 65.48 11.14 1232 1050073 64979 78628104
Angina pectoris 65.46 11.14 406 1050899 51326 78641757
Graft versus host disease in lung 65.34 11.14 70 1051235 842 78692241
Pulmonary function test decreased 64.88 11.14 235 1051070 7402 78685681
Ventricular extrasystoles 64.32 11.14 100 1051205 19604 78673479
Irritable bowel syndrome 64.29 11.14 1166 1050139 61075 78632008
Muscle injury 64.01 11.14 947 1050358 47614 78645469
Lupus nephritis 64.01 11.14 130 1051175 2878 78690205
Hepatic failure 63.91 11.14 508 1050797 60704 78632379
Jaundice 63.77 11.14 426 1050879 52923 78640160
Central nervous system lymphoma 63.75 11.14 111 1051194 2178 78690905
Liver function test abnormal 63.71 11.14 543 1050762 63932 78629151
Sudden death 63.71 11.14 125 1051180 22386 78670697
Acanthamoeba infection 63.61 11.14 53 1051252 452 78692631
Breast cancer stage I 63.59 11.14 7 1051298 6693 78686390
Product dose omission issue 63.29 11.14 2643 1048662 244894 78448189
Asphyxia 63.22 11.14 38 1051267 11682 78681401
Polyomavirus viraemia 62.89 11.14 94 1051211 1613 78691470
Encephalitis viral 62.83 11.14 118 1051187 2461 78690622
Lymphadenopathy 62.41 11.14 1018 1050287 52229 78640854
Sarcoidosis 62.15 11.14 246 1051059 8089 78684994
Eosinophilic granulomatosis with polyangiitis 61.70 11.14 144 1051161 3516 78689567
Heart rate irregular 61.66 11.14 681 1050624 31998 78661085
Body temperature decreased 61.63 11.14 672 1050633 31473 78661610
Electrolyte imbalance 61.49 11.14 205 1051100 30676 78662407
Hypernatraemia 61.20 11.14 60 1051245 14391 78678692
Device adhesion issue 60.95 11.14 10 1051295 7065 78686018
Cryptosporidiosis infection 60.36 11.14 61 1051244 682 78692401
Rhinitis allergic 60.09 11.14 320 1050985 11949 78681134
Electrocardiogram QRS complex prolonged 60.03 11.14 34 1051271 10799 78682284
Restless legs syndrome 60.00 11.14 108 1051197 19984 78673099
Ulcer 59.99 11.14 632 1050673 29340 78663743
Vasculitis 59.85 11.14 549 1050756 24553 78668530
Fibromyalgia 59.82 11.14 1186 1050119 63154 78629929
Antipsychotic drug level increased 59.77 11.14 5 1051300 5952 78687131
Renal tubular atrophy 59.70 11.14 96 1051209 1760 78691323
Wrist deformity 59.41 11.14 103 1051202 2014 78691069
Abscess 59.38 11.14 511 1050794 22440 78670643
Asthma-chronic obstructive pulmonary disease overlap syndrome 59.05 11.14 131 1051174 3090 78689993
Bronchopulmonary aspergillosis allergic 58.96 11.14 127 1051178 2934 78690149
Fear 58.90 11.14 126 1051179 21860 78671223
Disseminated coccidioidomycosis 58.67 11.14 32 1051273 120 78692963
Biopsy lung abnormal 58.36 11.14 33 1051272 135 78692948
Status epilepticus 57.95 11.14 155 1051150 24886 78668197
Nodule 57.43 11.14 508 1050797 22486 78670597
Rash maculo-papular 57.35 11.14 468 1050837 55610 78637473
Anxiety 57.25 11.14 2684 1048621 245828 78447255
Complication of device insertion 56.93 11.14 8 1051297 6342 78686741
Oral herpes 56.89 11.14 583 1050722 26871 78666212
Prothrombin time prolonged 56.86 11.14 84 1051221 16815 78676268
Bone density decreased 56.67 11.14 335 1050970 13012 78680071
Nasal oedema 56.59 11.14 90 1051215 1634 78691449
Sinus tachycardia 56.40 11.14 272 1051033 36636 78656447
Joint effusion 56.39 11.14 419 1050886 17595 78675488
Hepatic encephalopathy 56.37 11.14 149 1051156 24017 78669066
Babesiosis 56.20 11.14 43 1051262 320 78692763
Mass 56.19 11.14 409 1050896 17063 78676020
Unintentional medical device removal 56.09 11.14 16 1051289 7696 78685387
Musculoskeletal pain 55.98 11.14 1756 1049549 100598 78592485
Bronchial obstruction 55.81 11.14 117 1051188 2651 78690432
Mental status changes 55.47 11.14 589 1050716 66370 78626713
Cytomegalovirus chorioretinitis 55.47 11.14 179 1051126 5311 78687772
Device occlusion 55.37 11.14 45 1051260 11821 78681262
Mental impairment 55.36 11.14 104 1051201 18932 78674151
Pallor 55.31 11.14 409 1050896 49653 78643430
Disability 55.19 11.14 401 1050904 16719 78676364
Haematoma 55.04 11.14 432 1050873 51763 78641320
Vision blurred 54.76 11.14 1024 1050281 104874 78588209
Hypertonia 54.49 11.14 14 1051291 7218 78685865
Spirometry abnormal 54.07 11.14 65 1051240 894 78692189
Angina unstable 53.83 11.14 84 1051221 16443 78676640
Drug level above therapeutic 53.80 11.14 243 1051062 8480 78684603
Cerebral toxoplasmosis 53.77 11.14 105 1051200 2257 78690826
Tuberculosis 53.69 11.14 364 1050941 14834 78678249
Musculoskeletal disorder 53.65 11.14 474 1050831 20974 78672109
Chronic kidney disease 53.57 11.14 585 1050720 65569 78627514
Carotid artery occlusion 53.56 11.14 17 1051288 7630 78685453
Erythema multiforme 53.50 11.14 94 1051211 17557 78675526
Adrenal insufficiency 53.45 11.14 593 1050712 27894 78665189
Full blood count decreased 53.42 11.14 178 1051127 26641 78666442
Gastroenteritis norovirus 53.24 11.14 123 1051182 2983 78690100
Dry skin 53.19 11.14 606 1050699 67389 78625694
Swollen tongue 52.88 11.14 336 1050969 42234 78650849
Exposure via ingestion 52.87 11.14 4 1051301 5170 78687913
Urinary incontinence 52.83 11.14 319 1050986 40590 78652493
Vaginal haemorrhage 52.83 11.14 132 1051173 21685 78671398
Night sweats 52.78 11.14 973 1050332 51122 78641961
Maternal exposure during pregnancy 52.61 11.14 2252 1049053 134286 78558797
Metastases to central nervous system 52.60 11.14 84 1051221 16291 78676792
Cat scratch disease 52.42 11.14 43 1051262 358 78692725
Lip swelling 52.32 11.14 320 1050985 40591 78652492
Pulmonary fibrosis 52.31 11.14 845 1050460 43267 78649816
Subarachnoid haemorrhage 51.80 11.14 158 1051147 24307 78668776
Body temperature fluctuation 51.77 11.14 138 1051167 3669 78689414
Blood pressure decreased 51.68 11.14 961 1050344 98505 78594578
Plasma cell myeloma 51.53 11.14 451 1050854 52808 78640275
Thirst 51.31 11.14 105 1051200 18514 78674569
Abnormal dreams 51.14 11.14 45 1051260 11367 78681716
Blood phosphorus increased 51.14 11.14 37 1051268 10310 78682773
Bronchial disorder 51.11 11.14 106 1051199 2383 78690700
Presyncope 51.01 11.14 324 1050981 40730 78652353
Eosinophil count abnormal 50.94 11.14 56 1051249 695 78692388
Toxoplasmosis 50.92 11.14 111 1051194 2586 78690497
Skin lesion 50.91 11.14 805 1050500 41039 78652044
Necrotising retinitis 50.87 11.14 72 1051233 1173 78691910
Hypoglycaemic coma 50.63 11.14 3 1051302 4757 78688326
Mycobacterium haemophilum infection 50.56 11.14 28 1051277 109 78692974
Granuloma 50.33 11.14 230 1051075 8067 78685016
Apnoea 50.26 11.14 48 1051257 11656 78681427
Body height below normal 50.10 11.14 94 1051211 1959 78691124
Bronchial secretion retention 50.09 11.14 143 1051162 3961 78689122
Ileostomy 49.99 11.14 85 1051220 1635 78691448
Irritability 49.95 11.14 327 1050978 40817 78652266
Flushing 49.94 11.14 840 1050465 87428 78605655
Atrioventricular block complete 49.86 11.14 89 1051216 16521 78676562
Ear pain 49.79 11.14 657 1050648 32212 78660871
Muscle twitching 49.58 11.14 164 1051141 24600 78668483
Head injury 49.53 11.14 289 1051016 37080 78656003
Secretion discharge 49.08 11.14 353 1050952 14669 78678414
Paranoia 49.08 11.14 115 1051190 19317 78673766
Psychomotor hyperactivity 49.04 11.14 92 1051213 16757 78676326
Bradypnoea 49.02 11.14 10 1051295 6042 78687041
Pneumonia cryptococcal 48.83 11.14 79 1051226 1456 78691627
Hepatitis E 48.73 11.14 116 1051189 2870 78690213
Hepatosplenic T-cell lymphoma 48.67 11.14 59 1051246 819 78692264
Eosinophilic bronchitis 48.65 11.14 45 1051260 447 78692636
Incorrect product administration duration 48.55 11.14 52 1051253 11970 78681113
Hypophagia 48.53 11.14 374 1050931 44993 78648090
Ischaemic stroke 48.43 11.14 248 1051057 32883 78660200
Atrioventricular block second degree 48.19 11.14 18 1051287 7294 78685789
Personality change 48.17 11.14 38 1051267 10132 78682951
Pancreatic carcinoma 48.16 11.14 65 1051240 13512 78679571
Myopathy 48.15 11.14 448 1050857 20115 78672968
Polyp 47.90 11.14 223 1051082 7884 78685199
Faecaloma 47.84 11.14 49 1051256 11515 78681568
Mucocutaneous leishmaniasis 47.65 11.14 44 1051261 436 78692647
Human antichimeric antibody positive 47.57 11.14 81 1051224 1560 78691523
Dry mouth 47.43 11.14 845 1050460 87174 78605909
Respiratory symptom 47.31 11.14 155 1051150 4636 78688447
Microsporidia infection 47.29 11.14 61 1051244 905 78692178
Obstruction 47.20 11.14 151 1051154 4459 78688624
B-cell lymphoma recurrent 47.17 11.14 62 1051243 938 78692145
Mite allergy 47.14 11.14 69 1051236 1161 78691922
Drug screen positive 47.12 11.14 11 1051294 6052 78687031
Complication associated with device 47.09 11.14 100 1051205 17396 78675687
Renal cancer 47.05 11.14 55 1051250 12171 78680912
Lung disorder 46.98 11.14 1393 1049912 79164 78613919
Hyperthermia 46.97 11.14 105 1051200 17932 78675151
Granuloma skin 46.80 11.14 242 1051063 8932 78684151
Device issue 46.73 11.14 191 1051114 26917 78666166
Hyperprolactinaemia 46.71 11.14 4 1051301 4672 78688411
Haemoglobin decreased 46.66 11.14 2422 1048883 219697 78473386
Granulocytopenia 46.66 11.14 49 1051256 11382 78681701
Vital capacity decreased 46.64 11.14 85 1051220 1731 78691352
Middle insomnia 46.53 11.14 367 1050938 15702 78677381
Clonus 46.51 11.14 16 1051289 6824 78686259
Fungal skin infection 46.51 11.14 180 1051125 5856 78687227
Liver disorder 46.42 11.14 673 1050632 71744 78621339
Upper respiratory fungal infection 46.26 11.14 38 1051267 317 78692766
Cholestasis 46.21 11.14 451 1050854 51658 78641425
Complications of transplanted lung 46.19 11.14 43 1051262 431 78692652
C-reactive protein increased 46.15 11.14 2112 1049193 126915 78566168
Periostitis 46.13 11.14 50 1051255 610 78692473
Treatment noncompliance 46.09 11.14 453 1050852 51815 78641268
Enterococcal infection 46.08 11.14 359 1050946 15301 78677782
Ear pruritus 46.04 11.14 139 1051166 3976 78689107
Device use error 45.94 11.14 18 1051287 7083 78686000
Blood parathyroid hormone decreased 45.74 11.14 266 1051039 10270 78682813
Disseminated mycobacterium avium complex infection 45.73 11.14 31 1051274 186 78692897
Calciphylaxis 45.67 11.14 131 1051174 3639 78689444
Mood altered 45.58 11.14 105 1051200 17742 78675341
Skin necrosis 45.39 11.14 400 1050905 17687 78675396
Depressed mood 45.38 11.14 414 1050891 48066 78645017
Ammonia increased 45.20 11.14 22 1051283 7613 78685470
Sickle cell anaemia with crisis 45.15 11.14 24 1051281 7898 78685185
Cardiac failure chronic 45.15 11.14 48 1051257 11087 78681996
Fluid retention 45.02 11.14 648 1050657 69161 78623922
Enterovirus infection 44.87 11.14 87 1051218 1860 78691223
Herpes simplex hepatitis 44.75 11.14 45 1051260 500 78692583
Malignant fibrous histiocytoma 44.65 11.14 30 1051275 177 78692906
Acute generalised exanthematous pustulosis 44.47 11.14 101 1051204 17153 78675930
Contrast media allergy 44.47 11.14 101 1051204 2421 78690662
Opportunistic infection 44.31 11.14 111 1051194 2839 78690244
Eye infection toxoplasmal 44.26 11.14 45 1051260 507 78692576
Systemic infection 44.25 11.14 38 1051267 9714 78683369
Granulomatosis with polyangiitis 44.17 11.14 109 1051196 2761 78690322
Haematuria 44.03 11.14 640 1050665 68196 78624887
Eosinophil count increased 43.81 11.14 380 1050925 16725 78676358
Epstein-Barr virus test positive 43.80 11.14 64 1051241 1075 78692008
Lower respiratory tract congestion 43.76 11.14 134 1051171 3863 78689220
Atrioventricular block 43.27 11.14 74 1051231 13967 78679116
Exposure to SARS-CoV-2 43.09 11.14 88 1051217 1956 78691127
Scleritis 43.08 11.14 141 1051164 4215 78688868
Joint range of motion decreased 43.07 11.14 647 1050658 32635 78660448
Animal scratch 43.05 11.14 73 1051232 1401 78691682
Cytomegalovirus syndrome 43.00 11.14 34 1051271 267 78692816
Viral infection 42.73 11.14 801 1050504 42215 78650868
Breast cancer female 42.58 11.14 53 1051252 11408 78681675
Orf 42.44 11.14 20 1051285 50 78693033
Uterine perforation 42.42 11.14 15 1051290 6288 78686795
Bronchitis 42.39 11.14 2118 1049187 128526 78564557
SARS-CoV-2 RNA increased 42.29 11.14 24 1051281 99 78692984
Pancreatitis acute 42.04 11.14 434 1050871 49170 78643913
Deformity 42.03 11.14 243 1051062 9362 78683721
Obsessive-compulsive disorder 41.82 11.14 13 1051292 5914 78687169
Blood potassium increased 41.74 11.14 221 1051084 29054 78664029
Pneumoperitoneum 41.60 11.14 112 1051193 2996 78690087
Skin exfoliation 41.57 11.14 495 1050810 54605 78638478
Upper respiratory tract inflammation 41.57 11.14 3 1051302 4032 78689051
Amylase increased 41.47 11.14 52 1051253 11157 78681926
Sleep terror 41.45 11.14 5 1051300 4453 78688630
Peak expiratory flow rate decreased 41.33 11.14 48 1051257 635 78692448
Frustration tolerance decreased 41.16 11.14 202 1051103 7300 78685783
Glycosylated haemoglobin increased 41.05 11.14 124 1051181 19136 78673947
Neuroendocrine carcinoma of the skin 41.03 11.14 67 1051238 1245 78691838
Temperature regulation disorder 41.01 11.14 13 1051292 5840 78687243
Asthenia 40.90 11.14 6019 1045286 505670 78187413
Immunosuppressant drug level decreased 40.75 11.14 85 1051220 1919 78691164
Rheumatoid lung 40.73 11.14 136 1051169 4109 78688974
Dermatitis acneiform 40.60 11.14 43 1051262 9950 78683133
Hip arthroplasty 40.57 11.14 680 1050625 35076 78658007
Loss of therapeutic response 40.45 11.14 54 1051251 830 78692253
Long QT syndrome 40.37 11.14 14 1051291 5941 78687142
Histoplasmosis cutaneous 40.19 11.14 19 1051286 48 78693035
Epstein-Barr virus associated lymphoma 40.17 11.14 60 1051245 1029 78692054
Drug tolerance decreased 40.14 11.14 301 1051004 12677 78680406
Colorectal cancer 40.09 11.14 33 1051272 8614 78684469
Viraemia 40.03 11.14 105 1051200 2764 78690319
Speech disorder 39.98 11.14 492 1050813 53953 78639130
Bloody discharge 39.90 11.14 83 1051222 1870 78691213
Endocarditis bacterial 39.82 11.14 72 1051233 1457 78691626
Synovial cyst 39.80 11.14 248 1051057 9817 78683266
Kidney infection 39.70 11.14 452 1050853 21399 78671684
Breast cancer metastatic 39.67 11.14 33 1051272 8569 78684514
Multiple sclerosis 39.67 11.14 155 1051150 22127 78670956
Bone disorder 39.66 11.14 406 1050899 18707 78674376
Device leakage 39.50 11.14 51 1051254 10805 78682278
Psychomotor retardation 39.48 11.14 16 1051289 6168 78686915
Multiple drug therapy 39.37 11.14 4 1051301 4074 78689009
Dialysis 39.25 11.14 119 1051186 18343 78674740
Steroid withdrawal syndrome 39.24 11.14 48 1051257 673 78692410
Mycobacterium abscessus infection 39.02 11.14 63 1051242 1159 78691924
Gastric cancer 38.95 11.14 46 1051259 10133 78682950
Kaposi's sarcoma 38.85 11.14 49 1051256 710 78692373
Lymphoma 38.70 11.14 376 1050929 17084 78675999
Hypertensive crisis 38.59 11.14 142 1051163 20628 78672455
Antineutrophil cytoplasmic antibody positive 38.57 11.14 65 1051240 1241 78691842
Osteopenia 38.54 11.14 391 1050914 17973 78675110
Knee arthroplasty 38.47 11.14 792 1050513 42456 78650627
Emphysematous pyelonephritis 38.44 11.14 34 1051271 317 78692766
Skin plaque 38.35 11.14 258 1051047 10487 78682596
Tachypnoea 38.33 11.14 256 1051049 31807 78661276
Herpes simplex reactivation 38.32 11.14 39 1051266 440 78692643
Application site erythema 38.29 11.14 10 1051295 5100 78687983
Sensory disturbance 38.26 11.14 89 1051216 14988 78678095
Lupus-like syndrome 38.23 11.14 313 1050992 13544 78679539
Pain in extremity 38.09 11.14 5422 1045883 359116 78333967
Finger deformity 38.02 11.14 197 1051108 7277 78685806
Joint destruction 38.01 11.14 167 1051138 5758 78687325
Human bocavirus infection 37.98 11.14 48 1051257 697 78692386
Coordination abnormal 37.95 11.14 110 1051195 17202 78675881
Petit mal epilepsy 37.91 11.14 14 1051291 5713 78687370
Thrombotic microangiopathy 37.91 11.14 420 1050885 19749 78673334
Activated partial thromboplastin time prolonged 37.73 11.14 82 1051223 14146 78678937
Hiccups 37.67 11.14 46 1051259 9985 78683098
Enterobacter infection 37.59 11.14 139 1051166 4423 78688660
Pericarditis fungal 37.59 11.14 26 1051279 162 78692921
Disseminated varicella zoster virus infection 37.50 11.14 44 1051261 589 78692494
Pseudohyponatraemia 37.33 11.14 23 1051282 114 78692969
Ileus 37.30 11.14 198 1051107 26013 78667070
Lymph node calcification 37.30 11.14 36 1051269 379 78692704
Total lung capacity increased 37.21 11.14 89 1051216 2209 78690874
Right ventricular failure 37.18 11.14 171 1051134 23326 78669757
Accidental death 37.11 11.14 6 1051299 4285 78688798
Chest discomfort 37.07 11.14 2199 1049106 135845 78557238
Herpes zoster cutaneous disseminated 37.05 11.14 38 1051267 433 78692650
Social avoidant behaviour 36.89 11.14 9 1051296 4805 78688278
B-cell lymphoma 36.75 11.14 171 1051134 6044 78687039
Wrong patient received product 36.65 11.14 8 1051297 4610 78688473
Cutaneous blastomycosis 36.64 11.14 16 1051289 31 78693052
Encephalopathy 36.63 11.14 646 1050659 66751 78626332
Skin mass 36.60 11.14 206 1051099 7857 78685226
Necrotising herpetic retinopathy 36.34 11.14 22 1051283 105 78692978
Loose body in joint 36.33 11.14 63 1051242 1232 78691851
Femoral neck fracture 36.23 11.14 47 1051258 9937 78683146
Pulse absent 36.21 11.14 48 1051257 10055 78683028
Conjunctivitis allergic 36.20 11.14 74 1051231 1646 78691437
Somnambulism 36.20 11.14 15 1051290 5706 78687377
Body temperature increased 36.14 11.14 803 1050502 43617 78649466
Mycobacterium fortuitum infection 36.14 11.14 27 1051278 193 78692890
Anaphylactic reaction 36.14 11.14 834 1050471 82909 78610174
Post transplant distal limb syndrome 36.03 11.14 42 1051263 558 78692525
Pneumonia pseudomonal 35.96 11.14 164 1051141 5747 78687336
Atrial tachycardia 35.92 11.14 25 1051280 7108 78685975
Staphylococcal infection 35.90 11.14 1015 1050290 57280 78635803
Pulmonary hypertension 35.87 11.14 433 1050872 47647 78645436
Heparin-induced thrombocytopenia 35.73 11.14 45 1051260 9637 78683446
Systemic lupus erythematosus rash 35.63 11.14 77 1051228 1783 78691300
Coronary artery stenosis 35.60 11.14 69 1051236 12415 78680668
Cholecystitis chronic 35.57 11.14 47 1051258 9859 78683224
Angiosarcoma metastatic 35.55 11.14 23 1051282 126 78692957
Mouth ulceration 35.44 11.14 707 1050598 37687 78655396
Rhinitis 35.38 11.14 324 1050981 14483 78678600
Hepatocellular injury 35.36 11.14 429 1050876 47164 78645919
Bone swelling 35.20 11.14 73 1051232 1641 78691442
Therapy interrupted 35.13 11.14 255 1051050 31086 78661997
Lymphoproliferative disorder 35.07 11.14 157 1051148 5458 78687625
Reversible airways obstruction 34.94 11.14 84 1051221 2092 78690991
Medial tibial stress syndrome 34.86 11.14 23 1051282 131 78692952
Haematocrit decreased 34.83 11.14 583 1050722 60729 78632354
Illness 34.81 11.14 831 1050474 45680 78647403
Vertigo 34.78 11.14 671 1050634 68411 78624672
Gastritis 34.75 11.14 435 1050870 47558 78645525
Ejection fraction 34.74 11.14 86 1051219 2183 78690900
Ejection fraction decreased 34.70 11.14 290 1051015 34287 78658796
Polyuria 34.69 11.14 93 1051212 14921 78678162
Emphysema 34.66 11.14 348 1050957 15952 78677131
Neoplasm progression 34.65 11.14 476 1050829 51206 78641877
Anhedonia 34.64 11.14 92 1051213 14806 78678277
Oesophageal candidiasis 34.51 11.14 224 1051081 8994 78684089
Transfusion 34.48 11.14 154 1051151 21176 78671907
Face oedema 34.47 11.14 223 1051082 27913 78665170
Polycystic ovaries 34.44 11.14 119 1051186 3660 78689423
Bronchial polyp 34.30 11.14 19 1051286 74 78693009
End stage renal disease 34.24 11.14 277 1051028 11943 78681140
Genital haemorrhage 34.13 11.14 20 1051285 6235 78686848
Galactorrhoea 34.12 11.14 4 1051301 3642 78689441
Nodular regenerative hyperplasia 34.07 11.14 63 1051242 1298 78691785
Tenosynovitis 34.01 11.14 334 1050971 15220 78677863
Meningitis listeria 33.99 11.14 55 1051250 1014 78692069
Dissociation 33.94 11.14 6 1051299 4015 78689068
Subdural haemorrhage 33.93 11.14 18 1051287 5930 78687153
Right atrial hypertrophy 33.61 11.14 46 1051259 725 78692358
Cerebral haematoma 33.60 11.14 33 1051272 7909 78685174
Blood loss anaemia 33.59 11.14 99 1051206 15399 78677684
Infection parasitic 33.54 11.14 37 1051268 461 78692622
Disability assessment scale score increased 33.37 11.14 111 1051194 3347 78689736
Ankle deformity 33.36 11.14 44 1051261 668 78692415
Pre-engraftment immune reaction 33.35 11.14 31 1051274 310 78692773
Cold sweat 33.34 11.14 130 1051175 18569 78674514
Alveolar osteitis 33.25 11.14 48 1051257 797 78692286
Thinking abnormal 33.15 11.14 78 1051227 13083 78680000
Drug abuser 33.13 11.14 19 1051286 5994 78687089
Immune system disorder 33.10 11.14 254 1051051 10775 78682308
Intercepted product preparation error 33.08 11.14 4 1051301 3556 78689527
Hyperreflexia 33.05 11.14 37 1051268 8348 78684735
Pyomyositis 33.03 11.14 41 1051264 584 78692499
Bowel movement irregularity 32.95 11.14 168 1051137 6166 78686917
Diffuse large B-cell lymphoma refractory 32.92 11.14 64 1051241 1371 78691712
Weight fluctuation 32.90 11.14 265 1051040 11410 78681673
Osteomyelitis fungal 32.90 11.14 29 1051276 269 78692814
Allergy to animal 32.79 11.14 64 1051241 1375 78691708
Tumour marker increased 32.71 11.14 8 1051297 4264 78688819
Psychomotor skills impaired 32.70 11.14 14 1051291 5223 78687860
Nystagmus 32.58 11.14 50 1051255 9854 78683229
Herpes simplex oesophagitis 32.56 11.14 32 1051273 345 78692738
Donor specific antibody present 32.43 11.14 28 1051277 252 78692831
Blood potassium decreased 32.41 11.14 425 1050880 46087 78646996
Neutropenic sepsis 32.40 11.14 216 1051089 26848 78666235
Cytopenia 32.37 11.14 411 1050894 19972 78673111
Acute pulmonary histoplasmosis 32.34 11.14 27 1051278 231 78692852
Metastases to bone 32.32 11.14 189 1051116 24238 78668845
Cardiomegaly 32.21 11.14 209 1051096 26143 78666940
Sepsis 32.10 11.14 3086 1048219 266342 78426741
Drug ineffective for unapproved indication 32.07 11.14 894 1050411 50344 78642739
Lymphadenitis 32.02 11.14 134 1051171 4521 78688562
Sputum purulent 31.97 11.14 61 1051244 1288 78691795
Multifocal micronodular pneumocyte hyperplasia 31.95 11.14 18 1051287 73 78693010
Pulmonary mucormycosis 31.81 11.14 56 1051249 1109 78691974
Salmonellosis 31.74 11.14 73 1051232 1765 78691318
Cryptococcal fungaemia 31.73 11.14 23 1051282 156 78692927
Ventricular arrhythmia 31.68 11.14 42 1051263 8798 78684285
Pleural effusion 31.63 11.14 1578 1049727 143684 78549399
Priapism 31.58 11.14 10 1051295 4495 78688588
Chromaturia 31.57 11.14 204 1051101 25542 78667541
Alcohol poisoning 31.55 11.14 12 1051293 4809 78688274
Cryptococcal cutaneous infection 31.43 11.14 24 1051281 178 78692905
Bundle branch block right 31.38 11.14 63 1051242 11188 78681895
Dermatophytosis 31.37 11.14 35 1051270 442 78692641
Pruritus genital 31.37 11.14 10 1051295 4476 78688607
Second primary malignancy 31.31 11.14 308 1050997 14042 78679041
Human herpesvirus 6 infection 31.20 11.14 147 1051158 5223 78687860
Vascular hyalinosis 31.17 11.14 19 1051286 92 78692991
Nephrectomy 31.16 11.14 79 1051226 2036 78691047
Hypothyroidism 31.15 11.14 494 1050811 51898 78641185
Hyperaesthesia 31.13 11.14 72 1051233 12150 78680933
Chronic sinusitis 31.11 11.14 285 1051020 12741 78680342
Coronavirus infection 31.08 11.14 187 1051118 7310 78685773
Prostatic specific antigen increased 31.06 11.14 239 1051066 10147 78682936
Chest X-ray abnormal 31.02 11.14 194 1051111 7689 78685394
Drooling 30.95 11.14 20 1051285 5914 78687169
Colitis 30.95 11.14 1221 1050084 72086 78620997
Epidural lipomatosis 30.94 11.14 57 1051248 1171 78691912
Glomerular filtration rate decreased 30.93 11.14 174 1051131 22528 78670555
Unintended pregnancy 30.83 11.14 7 1051298 3926 78689157
Diplopia 30.80 11.14 287 1051018 33179 78659904
Tuberculin test positive 30.78 11.14 107 1051198 3301 78689782
Symptom masked 30.69 11.14 61 1051244 1329 78691754
Escherichia bacteraemia 30.68 11.14 169 1051136 6393 78686690
Oxalosis 30.55 11.14 19 1051286 96 78692987
Colitis ischaemic 30.55 11.14 102 1051203 15257 78677826
Aspiration 30.54 11.14 149 1051156 20009 78673074
Coagulopathy 30.52 11.14 315 1050990 35691 78657392
Lymphocyte count decreased 30.47 11.14 439 1050866 46850 78646233
Sinus node dysfunction 30.33 11.14 34 1051271 7667 78685416
Mycobacterium marinum infection 30.14 11.14 34 1051271 435 78692648
Wrist surgery 30.11 11.14 45 1051260 772 78692311
BK polyomavirus test positive 30.09 11.14 21 1051284 133 78692950
Fear of injection 30.08 11.14 185 1051120 7289 78685794
Tooth infection 30.03 11.14 380 1050925 18452 78674631
Heavy menstrual bleeding 30.01 11.14 90 1051215 13921 78679162
Rhonchi 29.99 11.14 119 1051186 3917 78689166
Left ventricular dysfunction 29.98 11.14 142 1051163 19219 78673864
Haemorrhagic stroke 29.84 11.14 63 1051242 10983 78682100
Faeces discoloured 29.82 11.14 243 1051062 28884 78664199
Dysuria 29.76 11.14 482 1050823 50469 78642614
Diabetic neuropathy 29.73 11.14 23 1051282 6193 78686890
Visual impairment 29.52 11.14 957 1050348 91174 78601909
Arthrodesis 29.51 11.14 84 1051221 2323 78690760
Eye abscess 29.49 11.14 29 1051276 313 78692770
Alcohol abuse 29.48 11.14 17 1051288 5346 78687737
Chorioretinopathy 29.46 11.14 80 1051225 2151 78690932
Respiratory tract inflammation 29.44 11.14 46 1051259 822 78692261
Device malfunction 29.43 11.14 164 1051141 21284 78671799
Pneumatosis intestinalis 29.41 11.14 164 1051141 6233 78686850
Respiratory acidosis 29.33 11.14 65 1051240 11135 78681948
Lymphocele 29.29 11.14 67 1051238 1614 78691469
On and off phenomenon 29.24 11.14 4 1051301 3236 78689847
Coombs positive haemolytic anaemia 29.16 11.14 53 1051252 1077 78692006
Transplant failure 29.16 11.14 130 1051175 4511 78688572
Blood thyroid stimulating hormone increased 29.15 11.14 52 1051253 9656 78683427
Abdominal abscess 29.06 11.14 177 1051128 6950 78686133
Lymphopenia 28.98 11.14 565 1050740 29992 78663091
Pulmonary cavitation 28.85 11.14 66 1051239 1590 78691493
Serum sickness 28.80 11.14 110 1051195 3556 78689527
Inflammatory bowel disease 28.78 11.14 149 1051156 5502 78687581
Breast cancer stage II 28.67 11.14 39 1051266 8081 78685002
Basal cell carcinoma 28.65 11.14 670 1050635 36705 78656378
Pulmonary embolism 28.64 11.14 1913 1049392 169741 78523342
Remission not achieved 28.61 11.14 31 1051274 378 78692705
Choroiditis 28.58 11.14 59 1051246 1322 78691761
Photodermatosis 28.50 11.14 48 1051257 916 78692167
Hepatic cancer 28.49 11.14 60 1051245 10469 78682614
Pneumonia necrotising 28.49 11.14 55 1051250 1172 78691911
Rectal abscess 28.41 11.14 77 1051228 2068 78691015
Respiratory rate increased 28.37 11.14 421 1050884 21179 78671904
Palmoplantar keratoderma 28.37 11.14 7 1051298 3709 78689374
Erythema nodosum 28.35 11.14 142 1051163 5175 78687908
Red blood cell count decreased 28.24 11.14 561 1050744 56952 78636131
New onset diabetes after transplantation 28.23 11.14 21 1051284 149 78692934
Tension headache 28.23 11.14 32 1051273 7179 78685904
Blood glucose decreased 28.18 11.14 216 1051089 26018 78667065
Cutaneous sporotrichosis 28.17 11.14 14 1051291 41 78693042
Disseminated sporotrichosis 28.17 11.14 14 1051291 41 78693042
Respiratory tract infection 28.13 11.14 841 1050464 47848 78645235
Wheelchair user 28.05 11.14 157 1051148 5975 78687108
Syringe issue 28.02 11.14 25 1051280 6273 78686810
Scleroderma renal crisis 27.95 11.14 37 1051268 564 78692519
Acute myeloid leukaemia 27.93 11.14 567 1050738 30318 78662765
Anal abscess 27.83 11.14 215 1051090 9140 78683943
Chronic graft versus host disease in skin 27.72 11.14 63 1051242 1511 78691572
Mental disorder 27.72 11.14 271 1051034 31031 78662052
Blister 27.64 11.14 1879 1049426 117597 78575486
Mitral valve incompetence 27.58 11.14 242 1051063 28323 78664760
Urinary tract discomfort 27.58 11.14 41 1051264 700 78692383
Bacterial infection 27.55 11.14 572 1050733 30708 78662375
Eye infection syphilitic 27.53 11.14 9 1051296 3 78693080
Psychiatric decompensation 27.42 11.14 9 1051296 3954 78689129
T-cell lymphoma 27.36 11.14 56 1051249 1247 78691836
Elbow deformity 27.33 11.14 62 1051243 1485 78691598
Wrong product administered 27.31 11.14 48 1051257 8964 78684119
Intestinal resection 27.30 11.14 110 1051195 3647 78689436
Lung abscess 27.22 11.14 117 1051188 3995 78689088
Cytomegalovirus nephritis 27.21 11.14 20 1051285 139 78692944
Abortion incomplete 27.15 11.14 4 1051301 3060 78690023
Metastases to lung 27.09 11.14 135 1051170 18028 78675055
Systemic mycosis 27.00 11.14 87 1051218 2579 78690504
Therapeutic product effect delayed 26.96 11.14 95 1051210 2951 78690132
Lung hyperinflation 26.93 11.14 69 1051236 1790 78691293
Acarodermatitis 26.93 11.14 58 1051247 1340 78691743
Hypovolaemic shock 26.91 11.14 78 1051227 12198 78680885
Peripheral arterial occlusive disease 26.87 11.14 42 1051263 8216 78684867
Haemorrhage subcutaneous 26.78 11.14 15 1051290 4794 78688289
Ovarian hyperstimulation syndrome 26.74 11.14 7 1051298 3564 78689519
Tinnitus 26.69 11.14 417 1050888 43916 78649167
Ventricular remodelling 26.68 11.14 18 1051287 107 78692976
Incorrect dose administered 26.67 11.14 1251 1050054 75379 78617704
Central nervous system vasculitis 26.64 11.14 58 1051247 1350 78691733
Abscess bacterial 26.64 11.14 43 1051262 791 78692292
Forced vital capacity decreased 26.62 11.14 66 1051239 1677 78691406
Multiple-drug resistance 26.61 11.14 47 1051258 8761 78684322
Emotional distress 26.48 11.14 369 1050936 39600 78653483
Sleep apnoea syndrome 26.46 11.14 649 1050656 35829 78657254
Nephropathy toxic 26.44 11.14 397 1050908 20022 78673061
Lipodystrophy acquired 26.32 11.14 12 1051293 4313 78688770
Device related infection 26.29 11.14 307 1050998 33987 78659096
Giant cell arteritis 26.27 11.14 88 1051217 2663 78690420
Squamous cell carcinoma of skin 26.27 11.14 292 1051013 13741 78679342
Respiratory failure 26.24 11.14 2747 1048558 178164 78514919
Blood prolactin increased 26.23 11.14 10 1051295 4001 78689082
Incontinence 26.20 11.14 97 1051208 14067 78679016
Aplastic anaemia 26.18 11.14 134 1051171 17771 78675312
Oesophageal carcinoma 26.11 11.14 68 1051237 11016 78682067
Electrocardiogram ST segment elevation 26.11 11.14 44 1051261 8353 78684730
Haemolytic uraemic syndrome 26.01 11.14 122 1051183 4327 78688756
Tumour haemorrhage 26.00 11.14 11 1051294 4133 78688950
Diabetes mellitus inadequate control 25.96 11.14 200 1051105 24064 78669019
Toxic anterior segment syndrome 25.95 11.14 3 1051302 2761 78690322
Kounis syndrome 25.87 11.14 12 1051293 4270 78688813
Limb mass 25.86 11.14 105 1051200 3494 78689589
Caesarean section 25.80 11.14 82 1051223 12453 78680630
Akinesia 25.76 11.14 6 1051299 3306 78689777
Urine output decreased 25.72 11.14 136 1051169 17886 78675197
Pleural thickening 25.54 11.14 92 1051213 2890 78690193
Dermatomyositis 25.47 11.14 105 1051200 3518 78689565
Diabetic retinopathy 25.43 11.14 5 1051300 3101 78689982
Substance-induced psychotic disorder 25.25 11.14 100 1051205 3289 78689794
Primary effusion lymphoma 25.25 11.14 13 1051292 42 78693041
Paranasal sinus discomfort 25.18 11.14 121 1051184 4335 78688748
Cholelithiasis 25.17 11.14 516 1050789 52148 78640935
Acute coronary syndrome 25.13 11.14 169 1051136 20964 78672119
Sinus congestion 25.05 11.14 385 1050920 19511 78673572
Complication of device removal 24.93 11.14 10 1051295 3879 78689204
Thyroid neoplasm 24.91 11.14 95 1051210 3069 78690014
Meningitis enterococcal 24.82 11.14 16 1051289 87 78692996
Renal transplant 24.79 11.14 82 1051223 2465 78690618
Nasal disorder 24.77 11.14 107 1051198 3662 78689421
Necrotising oesophagitis 24.76 11.14 49 1051256 1064 78692019
Intestinal perforation 24.62 11.14 344 1050961 17082 78676001
Sinusitis bacterial 24.53 11.14 65 1051240 1722 78691361
Seasonal allergy 24.46 11.14 327 1050978 16079 78677004
International normalised ratio decreased 24.44 11.14 43 1051262 8027 78685056
Disseminated strongyloidiasis 24.44 11.14 23 1051282 234 78692849
Anticipatory anxiety 24.40 11.14 51 1051254 1153 78691930
Mycoplasma infection 24.28 11.14 40 1051265 749 78692334
Intermenstrual bleeding 24.27 11.14 25 1051280 5859 78687224
Smoke sensitivity 24.25 11.14 35 1051270 581 78692502
Ankylosing spondylitis 24.25 11.14 257 1051048 11948 78681135
Joint laxity 24.20 11.14 77 1051228 2267 78690816
Blood triglycerides increased 24.16 11.14 170 1051135 20870 78672213
Solar lentigo 24.15 11.14 49 1051256 1084 78691999
Episcleritis 24.14 11.14 47 1051258 1008 78692075
Complications of transplant surgery 24.14 11.14 39 1051266 718 78692365
Large intestinal ulcer 24.10 11.14 126 1051179 4671 78688412
Myelodysplastic syndrome 24.09 11.14 546 1050759 29755 78663328
Pregnancy with contraceptive device 24.08 11.14 9 1051296 3645 78689438
Colectomy total 24.02 11.14 27 1051278 344 78692739
Eye movement disorder 23.98 11.14 43 1051262 7968 78685115
Cutaneous nocardiosis 23.98 11.14 21 1051284 193 78692890
Glaucoma 23.98 11.14 380 1050925 19381 78673702
Hypertrophic osteoarthropathy 23.96 11.14 17 1051288 111 78692972
Oesophageal varices haemorrhage 23.90 11.14 13 1051292 4223 78688860
Restrictive pulmonary disease 23.89 11.14 82 1051223 2513 78690570
Jaundice cholestatic 23.80 11.14 73 1051232 11211 78681872
Chronic obstructive pulmonary disease 23.74 11.14 1365 1049940 84054 78609029
Stress cardiomyopathy 23.72 11.14 72 1051233 11094 78681989
Dysplastic naevus 23.71 11.14 34 1051271 561 78692522
Cyst 23.68 11.14 283 1051022 13557 78679526
Post procedural haemorrhage 23.59 11.14 97 1051208 13647 78679436
Dermatitis bullous 23.54 11.14 102 1051203 14143 78678940
Mitochondrial toxicity 23.52 11.14 6 1051299 3108 78689975
Vascular device infection 23.48 11.14 64 1051241 10212 78682871
Coronary arterial stent insertion 23.46 11.14 27 1051278 6017 78687066
Segmental diverticular colitis 23.46 11.14 19 1051286 155 78692928
Urticaria 23.41 11.14 2787 1048518 182414 78510669
Disseminated aspergillosis 23.41 11.14 48 1051257 1070 78692013
Bacterial pyelonephritis 23.39 11.14 33 1051272 536 78692547
Tractional retinal detachment 23.35 11.14 15 1051290 81 78693002
Gastrointestinal inflammation 23.35 11.14 175 1051130 7369 78685714
Traumatic lung injury 23.29 11.14 77 1051228 2314 78690769
Mantle cell lymphoma recurrent 23.27 11.14 34 1051271 571 78692512
Disseminated cytomegaloviral infection 23.26 11.14 30 1051275 445 78692638
Apparent mineralocorticoid excess 23.26 11.14 12 1051293 39 78693044
Hypotonia 23.25 11.14 89 1051216 12781 78680302
Carpal tunnel syndrome 23.12 11.14 374 1050931 19154 78673929
Bacterial sepsis 23.06 11.14 186 1051119 8012 78685071
Multiple allergies 23.06 11.14 225 1051080 10235 78682848
Cell-mediated immune deficiency 23.03 11.14 17 1051288 119 78692964
Acidosis 23.02 11.14 159 1051146 19603 78673480
Congenital hiatus hernia 23.00 11.14 40 1051265 784 78692299
Alcohol use 22.95 11.14 18 1051287 4813 78688270
Appendicitis 22.91 11.14 170 1051135 20624 78672459
Osteoarthritis 22.90 11.14 1388 1049917 85921 78607162
Immunodeficiency 22.90 11.14 409 1050896 21359 78671724
Abscess limb 22.89 11.14 165 1051140 6862 78686221
Malignant transformation 22.85 11.14 50 1051255 1168 78691915
Abscess intestinal 22.82 11.14 84 1051221 2667 78690416
Sarcoma of skin 22.78 11.14 14 1051291 69 78693014
Encephalitis 22.76 11.14 296 1051009 14464 78678619
Blood iron decreased 22.75 11.14 307 1050998 15127 78677956
Bezoar 22.71 11.14 4 1051301 2684 78690399
Pericardial effusion 22.70 11.14 451 1050854 45786 78647297
Herpes virus infection 22.66 11.14 165 1051140 6884 78686199
Interstitial lung disease 22.65 11.14 1751 1049554 110849 78582234
Epstein Barr virus positive mucocutaneous ulcer 22.62 11.14 40 1051265 795 78692288
Skin squamous cell carcinoma recurrent 22.61 11.14 12 1051293 42 78693041
Folate deficiency 22.61 11.14 8 1051297 3352 78689731
Cerebral venous sinus thrombosis 22.52 11.14 74 1051231 2217 78690866
Clear cell renal cell carcinoma 22.51 11.14 80 1051225 2496 78690587
Pruritus allergic 22.46 11.14 54 1051251 1345 78691738
Tearfulness 22.41 11.14 28 1051277 6017 78687066
Perfume sensitivity 22.40 11.14 41 1051264 838 78692245
Plasmablastic lymphoma 22.31 11.14 31 1051274 496 78692587
Ophthalmic herpes zoster 22.30 11.14 82 1051223 2602 78690481
Pleomorphic malignant fibrous histiocytoma 22.19 11.14 11 1051294 32 78693051
Purulent pericarditis 22.17 11.14 14 1051291 73 78693010
Cutaneous calcification 22.17 11.14 17 1051288 127 78692956
International normalised ratio abnormal 22.14 11.14 26 1051279 5742 78687341
Cutaneous malacoplakia 22.13 11.14 16 1051289 108 78692975
Contusion 22.13 11.14 2263 1049042 146513 78546570
Sinus arrest 22.12 11.14 10 1051295 3612 78689471
Tic 22.08 11.14 6 1051299 2980 78690103
Pulmonary toxicity 22.07 11.14 264 1051041 12650 78680433
Product physical issue 21.97 11.14 14 1051291 4171 78688912
Pseudomembranous colitis 21.97 11.14 23 1051282 5351 78687732
Pancreatic carcinoma metastatic 21.94 11.14 11 1051294 3742 78689341
Neurosarcoidosis 21.94 11.14 26 1051279 352 78692731
Nodal rhythm 21.90 11.14 7 1051298 3128 78689955
Ear infection 21.89 11.14 602 1050703 33830 78659253
Latent tuberculosis 21.89 11.14 95 1051210 3258 78689825
Prophylaxis against transplant rejection 21.88 11.14 14 1051291 75 78693008
Haemorrhage intracranial 21.85 11.14 230 1051075 25963 78667120
Blood pH decreased 21.82 11.14 18 1051287 4693 78688390
Metastatic squamous cell carcinoma 21.79 11.14 32 1051273 540 78692543
Cardiomyopathy acute 21.76 11.14 24 1051281 299 78692784
Papilloma viral infection 21.73 11.14 61 1051244 1673 78691410
Pedal pulse abnormal 21.66 11.14 19 1051286 175 78692908
Behaviour disorder 21.61 11.14 31 1051274 6282 78686801
Hallucinations, mixed 21.59 11.14 36 1051269 6863 78686220
Antisynthetase syndrome 21.56 11.14 18 1051287 154 78692929
Anger 21.55 11.14 135 1051170 17027 78676056
Squamous cell carcinoma 21.51 11.14 307 1050998 15315 78677768
Diarrhoea haemorrhagic 21.51 11.14 268 1051037 12966 78680117
Decubitus ulcer 21.50 11.14 120 1051185 15567 78677516
Superinfection bacterial 21.50 11.14 56 1051249 1468 78691615
Cardioactive drug level increased 21.49 11.14 11 1051294 3698 78689385
Cytomegalovirus infection reactivation 21.48 11.14 192 1051113 8524 78684559
Anal fistula 21.44 11.14 161 1051144 6783 78686300
Pyoderma gangrenosum 21.43 11.14 110 1051195 4048 78689035
Meningoencephalitis viral 21.43 11.14 28 1051277 421 78692662
Oxygen saturation decreased 21.41 11.14 1978 1049327 127069 78566014
Cholecystitis acute 21.22 11.14 98 1051207 13353 78679730
Vasogenic cerebral oedema 21.20 11.14 55 1051250 1438 78691645
Polydipsia 21.10 11.14 34 1051271 6571 78686512
Swollen joint count increased 21.10 11.14 422 1050883 22505 78670578
Rhinovirus infection 21.06 11.14 178 1051127 7775 78685308
Inadequate analgesia 21.05 11.14 18 1051287 4611 78688472
Application site pruritus 21.05 11.14 12 1051293 3798 78689285
Laryngeal mass 21.01 11.14 13 1051292 65 78693018
Blood chloride decreased 20.97 11.14 48 1051257 8129 78684954
Norovirus test positive 20.96 11.14 34 1051271 628 78692455
Oesophageal stenosis 20.94 11.14 113 1051192 4241 78688842
Erysipelothrix infection 20.94 11.14 7 1051298 3 78693080
Capnocytophaga infection 20.92 11.14 16 1051289 119 78692964
Chromoblastomycosis 20.92 11.14 14 1051291 82 78693001
Oral pain 20.91 11.14 294 1051011 31504 78661579
Herpes simplex encephalitis 20.90 11.14 36 1051269 700 78692383
Tuberculosis of central nervous system 20.87 11.14 29 1051276 464 78692619
Morganella infection 20.84 11.14 46 1051259 1081 78692002
Arthritis infective 20.80 11.14 183 1051122 8088 78684995
Viral vasculitis 20.77 11.14 17 1051288 141 78692942
Toxic encephalopathy 20.74 11.14 79 1051226 11361 78681722
Complications of transplanted heart 20.73 11.14 25 1051280 345 78692738
Gastric haemorrhage 20.69 11.14 115 1051190 14935 78678148
Hypoxia 20.67 11.14 1131 1050174 102112 78590971
Eructation 20.65 11.14 74 1051231 10835 78682248
Hyperthyroidism 20.63 11.14 190 1051115 22019 78671064
Taste disorder 20.63 11.14 123 1051182 15700 78677383
Product complaint 20.62 11.14 98 1051207 13251 78679832
Atypical mycobacterial infection 20.57 11.14 60 1051245 1683 78691400
Obstructive nephropathy 20.53 11.14 12 1051293 53 78693030
Abdominal pain upper 20.53 11.14 2610 1048695 221209 78471874
Embedded device 20.52 11.14 9 1051296 3310 78689773
Cutaneous leishmaniasis 20.52 11.14 23 1051282 292 78692791
Chronic spontaneous urticaria 20.46 11.14 48 1051257 1176 78691907
Hypophosphataemia 20.44 11.14 166 1051139 19747 78673336
Diabetic cardiomyopathy 20.44 11.14 10 1051295 28 78693055
Cutaneous coccidioidomycosis 20.43 11.14 9 1051296 18 78693065
Limb injury 20.43 11.14 522 1050783 29006 78664077
Lung diffusion test decreased 20.42 11.14 50 1051255 1260 78691823
Hemiparesis 20.41 11.14 317 1050988 33416 78659667
Homicidal ideation 20.41 11.14 10 1051295 3447 78689636
Demodicidosis 20.40 11.14 20 1051285 215 78692868
Thrombosis in device 20.39 11.14 25 1051280 5417 78687666
Blood bicarbonate decreased 20.36 11.14 23 1051282 5168 78687915
Extrasystoles 20.31 11.14 42 1051263 7377 78685706
Hernia 20.30 11.14 327 1050978 16732 78676351
Complement factor C3 decreased 20.30 11.14 25 1051280 353 78692730
Dyspepsia 20.24 11.14 1199 1050106 107488 78585595
Human herpes virus 8 test positive 20.22 11.14 11 1051294 41 78693042
Eosinophil count 20.20 11.14 16 1051289 126 78692957
Bronchial neoplasm 20.20 11.14 29 1051276 479 78692604
Angiocentric lymphoma 20.20 11.14 40 1051265 869 78692214
Infective tenosynovitis 20.19 11.14 26 1051279 385 78692698
Choriomeningitis lymphocytic 20.19 11.14 12 1051293 55 78693028
Pancreatitis 20.17 11.14 720 1050585 67855 78625228
Anion gap increased 20.15 11.14 12 1051293 3708 78689375
Drug dose omission by device 20.13 11.14 32 1051273 6218 78686865
Product dispensing error 20.12 11.14 98 1051207 13165 78679918
Atypical haemolytic uraemic syndrome 20.09 11.14 43 1051262 989 78692094
Cerebral fungal infection 19.99 11.14 27 1051278 420 78692663
Hypofibrinogenaemia 19.98 11.14 65 1051240 1937 78691146
Campylobacter infection 19.97 11.14 62 1051243 1801 78691282
Furuncle 19.97 11.14 169 1051136 7385 78685698
Hypersensitivity myocarditis 19.96 11.14 21 1051284 247 78692836
Acute hepatic failure 19.95 11.14 278 1051027 29835 78663248
Pancreas transplant rejection 19.94 11.14 23 1051282 302 78692781
Hypoalbuminaemia 19.87 11.14 182 1051123 21115 78671968
Pulmonary arterial hypertension 19.83 11.14 259 1051046 28107 78664976
Intestinal stenosis 19.83 11.14 100 1051205 3654 78689429
Herpes dermatitis 19.78 11.14 14 1051291 91 78692992
Crohn's disease 19.77 11.14 66 1051239 1994 78691089
Trichophytosis 19.68 11.14 25 1051280 365 78692718
Lacunar infarction 19.67 11.14 30 1051275 5927 78687156
Atrial flutter 19.66 11.14 186 1051119 21439 78671644
Gastrooesophageal reflux disease 19.65 11.14 1613 1049692 102633 78590450
Malignant melanoma 19.63 11.14 288 1051017 14453 78678630
Sudden cardiac death 19.58 11.14 24 1051281 5201 78687882
Splenic marginal zone lymphoma 19.55 11.14 12 1051293 59 78693024
Prostate cancer stage IV 19.53 11.14 4 1051301 2410 78690673
Myringotomy 19.52 11.14 9 1051296 21 78693062
Disseminated Bacillus Calmette-Guerin infection 19.40 11.14 19 1051286 204 78692879
Disseminated intravascular coagulation 19.33 11.14 344 1050961 35498 78657585
Pleural mesothelioma malignant 19.26 11.14 17 1051288 158 78692925
Acute hepatitis C 19.25 11.14 19 1051286 206 78692877
Skin fragility 19.24 11.14 40 1051265 901 78692182
Cystitis bacterial 19.22 11.14 34 1051271 676 78692407
Gastrosplenic fistula 19.15 11.14 15 1051290 116 78692967
Tendon disorder 19.12 11.14 161 1051144 7025 78686058
Infective scleritis 19.09 11.14 11 1051294 47 78693036
Myasthenia gravis crisis 19.05 11.14 44 1051261 1067 78692016
Nasal turbinate hypertrophy 19.04 11.14 34 1051271 681 78692402
Crepitations 19.01 11.14 209 1051096 9808 78683275
Urinary tract infection bacterial 18.99 11.14 148 1051157 6308 78686775
Product adhesion issue 18.96 11.14 6 1051299 2698 78690385
Coronary artery occlusion 18.96 11.14 121 1051184 15194 78677889
Throat irritation 18.95 11.14 689 1050616 40257 78652826
Extrapulmonary tuberculosis 18.93 11.14 25 1051280 380 78692703
Faecal calprotectin abnormal 18.91 11.14 18 1051287 186 78692897
Anaesthetic complication 18.91 11.14 7 1051298 2852 78690231
Supraventricular tachycardia 18.89 11.14 184 1051121 21086 78671997
Tuberculosis gastrointestinal 18.89 11.14 30 1051275 544 78692539
Intestinal anastomosis 18.80 11.14 33 1051272 652 78692431
Cytology abnormal 18.77 11.14 23 1051282 323 78692760
Erythropoiesis abnormal 18.76 11.14 27 1051278 447 78692636
Bordetella infection 18.75 11.14 14 1051291 100 78692983
Chorioretinitis 18.73 11.14 42 1051263 998 78692085
Cross sensitivity reaction 18.71 11.14 13 1051292 3699 78689384
Hyperlipidaemia 18.70 11.14 237 1051068 25856 78667227
Proteus infection 18.70 11.14 66 1051239 2052 78691031
Bone density abnormal 18.69 11.14 85 1051220 2975 78690108
Urate nephropathy 18.69 11.14 17 1051288 165 78692918
Grip strength decreased 18.64 11.14 398 1050907 21471 78671612
Logorrhoea 18.63 11.14 18 1051287 4347 78688736
Perinephric abscess 18.52 11.14 20 1051285 243 78692840
Gastroenteritis cryptosporidial 18.48 11.14 21 1051284 271 78692812
Sinusitis fungal 18.46 11.14 71 1051234 2303 78690780
Hypervolaemia 18.45 11.14 425 1050880 42265 78650818
Skin graft rejection 18.45 11.14 9 1051296 25 78693058
Cutaneous mucormycosis 18.39 11.14 18 1051287 193 78692890
Acinetobacter infection 18.37 11.14 79 1051226 2698 78690385
Injection site induration 18.33 11.14 67 1051238 9752 78683331
Hepatitis fulminant 18.32 11.14 43 1051262 7219 78685864
Paronychia 18.32 11.14 48 1051257 7760 78685323
Feeling abnormal 18.31 11.14 1828 1049477 157371 78535712
Emphysematous cystitis 18.30 11.14 23 1051282 332 78692751
Incoherent 18.27 11.14 47 1051258 7645 78685438
Urinary tract candidiasis 18.25 11.14 35 1051270 742 78692341
Pneumonia fungal 18.21 11.14 227 1051078 10983 78682100
Rectal tenesmus 18.20 11.14 56 1051249 1619 78691464
Meningitis haemophilus 18.16 11.14 8 1051297 16 78693067
Antibody test positive 18.14 11.14 79 1051226 2713 78690370
Broncholithiasis 18.09 11.14 19 1051286 223 78692860
Arteriosclerosis coronary artery 18.07 11.14 149 1051156 17667 78675416
Low density lipoprotein increased 18.03 11.14 56 1051249 8566 78684517
Prosthesis user 17.97 11.14 12 1051293 70 78693013
Intestinal pseudo-obstruction 17.92 11.14 6 1051299 2603 78690480
Device deployment issue 17.91 11.14 10 1051295 3202 78689881
Skin papilloma 17.91 11.14 136 1051169 5750 78687333
Multiple fractures 17.87 11.14 173 1051132 7853 78685230
Colon cancer 17.84 11.14 115 1051190 14408 78678675
Localised infection 17.82 11.14 634 1050671 36941 78656142
Disinhibition 17.80 11.14 6 1051299 2592 78690491
Diaphragmatic hernia 17.78 11.14 24 1051281 373 78692710
Arteriosclerosis 17.78 11.14 154 1051151 18073 78675010
Diverticulum intestinal haemorrhagic 17.75 11.14 16 1051289 3995 78689088
Blood pressure inadequately controlled 17.74 11.14 34 1051271 6143 78686940
Bronchopleural fistula 17.72 11.14 32 1051273 647 78692436
Bradykinesia 17.71 11.14 51 1051254 7992 78685091
Corynebacterium infection 17.69 11.14 48 1051257 1290 78691793
Cryopyrin associated periodic syndrome 17.69 11.14 24 1051281 375 78692708
Refusal of treatment by patient 17.68 11.14 60 1051245 8931 78684152
Therapy cessation 17.66 11.14 369 1050936 37193 78655890
Rheumatic fever 17.65 11.14 497 1050808 28028 78665055
Renal tubular injury 17.65 11.14 52 1051253 1467 78691616
Hepatitis acute 17.64 11.14 126 1051179 15416 78677667
Major depression 17.61 11.14 60 1051245 8920 78684163
Abdominal distension 17.58 11.14 1348 1049957 118302 78574781
Lyme disease 17.53 11.14 89 1051216 3261 78689822
Lupus vasculitis 17.53 11.14 29 1051276 545 78692538
Alcoholism 17.52 11.14 14 1051291 3709 78689374
Catatonia 17.52 11.14 58 1051247 8698 78684385
Haemodialysis 17.50 11.14 154 1051151 18014 78675069
Metabolic alkalosis 17.48 11.14 20 1051285 4469 78688614
Gynaecomastia 17.43 11.14 48 1051257 7633 78685450
Cytokine release syndrome 17.41 11.14 352 1050953 35646 78657437
Trichosporon infection 17.37 11.14 40 1051265 968 78692115
Blood uric acid increased 17.34 11.14 104 1051201 13256 78679827
Panic attack 17.34 11.14 220 1051085 23996 78669087
Empyema 17.31 11.14 106 1051199 4170 78688913
Urine ketone body present 17.29 11.14 13 1051292 3552 78689531
Chronic hepatitis 17.26 11.14 50 1051255 1397 78691686
Colitis microscopic 17.25 11.14 78 1051227 10690 78682393
Post procedural discharge 17.23 11.14 33 1051272 699 78692384
Lung opacity 17.15 11.14 122 1051183 5052 78688031
Haemorrhagic transformation stroke 17.13 11.14 7 1051298 2685 78690398
Type 2 diabetes mellitus 17.08 11.14 919 1050386 56203 78636880
Virologic failure 17.07 11.14 18 1051287 4173 78688910
Loss of libido 17.05 11.14 7 1051298 2678 78690405
Ear congestion 17.03 11.14 80 1051225 2839 78690244
Superior sagittal sinus thrombosis 17.03 11.14 41 1051264 1022 78692061
Haemorrhage 17.00 11.14 1005 1050300 90113 78602970
Pneumonia legionella 16.99 11.14 80 1051225 2842 78690241
Forced expiratory flow decreased 16.97 11.14 20 1051285 269 78692814
Cryptococcal meningoencephalitis 16.97 11.14 19 1051286 241 78692842
Actinic keratosis 16.95 11.14 137 1051168 5905 78687178
Peritoneal dialysis complication 16.91 11.14 5 1051300 2349 78690734
Nipple swelling 16.87 11.14 21 1051284 300 78692783
Stenotrophomonas infection 16.86 11.14 96 1051209 3677 78689406
International normalised ratio fluctuation 16.86 11.14 90 1051215 3364 78689719
Cholangitis 16.82 11.14 99 1051206 12677 78680406
Blood thyroid stimulating hormone decreased 16.82 11.14 31 1051274 5685 78687398
Needle issue 16.82 11.14 102 1051203 12966 78680117
Acute pulmonary oedema 16.82 11.14 114 1051191 14116 78678967
Biloma 16.78 11.14 15 1051290 142 78692941
Breast cancer 16.73 11.14 329 1050976 33452 78659631
Unevaluable event 16.72 11.14 582 1050723 55003 78638080
Autoinflammatory disease 16.72 11.14 21 1051284 303 78692780
Granulomatous dermatitis 16.69 11.14 24 1051281 397 78692686
Graft complication 16.69 11.14 33 1051272 716 78692367
Acute polyneuropathy 16.67 11.14 26 1051279 464 78692619
Abdominal wall infection 16.65 11.14 13 1051292 100 78692983
Urinary hesitation 16.62 11.14 19 1051286 4247 78688836
Transitional cell carcinoma 16.59 11.14 72 1051233 2469 78690614
Bone erosion 16.59 11.14 329 1050976 17518 78675565
Tendon rupture 16.58 11.14 238 1051067 11888 78681195
Periorbital oedema 16.57 11.14 56 1051249 8346 78684737
Anovulatory cycle 16.57 11.14 14 1051291 122 78692961
Language disorder 16.54 11.14 11 1051294 3203 78689880
Respiratory tract infection fungal 16.53 11.14 44 1051261 1169 78691914
Pseudopolyp 16.52 11.14 25 1051280 434 78692649
Tongue oedema 16.51 11.14 44 1051261 7073 78686010
Troponin increased 16.51 11.14 168 1051137 19087 78673996
Ageusia 16.46 11.14 140 1051165 16492 78676591
Joint warmth 16.45 11.14 53 1051252 1571 78691512
Borderline leprosy 16.45 11.14 8 1051297 22 78693061
Rheumatoid factor negative 16.44 11.14 43 1051262 1130 78691953
Rash erythematous 16.44 11.14 609 1050696 57160 78635923
Asthmatic crisis 16.43 11.14 61 1051244 1945 78691138
Cerebellar haemorrhage 16.42 11.14 9 1051296 2911 78690172
Abnormal loss of weight 16.40 11.14 56 1051249 8320 78684763
Drug eruption 16.40 11.14 447 1050858 43488 78649595
Intervertebral disc degeneration 16.40 11.14 296 1051009 15489 78677594
Spinal disorder 16.34 11.14 207 1051098 10053 78683030
Gastroenteritis sapovirus 16.30 11.14 15 1051290 148 78692935
Enterocolonic fistula 16.22 11.14 15 1051290 149 78692934
Tumour lysis syndrome 16.21 11.14 422 1050883 23517 78669566
Herpes oesophagitis 16.19 11.14 23 1051282 376 78692707
Vascular stent thrombosis 16.18 11.14 15 1051290 3695 78689388
Enuresis 16.17 11.14 11 1051294 3165 78689918
Soft tissue injury 16.16 11.14 56 1051249 1725 78691358
Device breakage 16.12 11.14 79 1051226 10596 78682487
Retroperitoneal lymphadenopathy 16.11 11.14 41 1051264 1059 78692024
Vitamin D deficiency 16.09 11.14 116 1051189 14163 78678920
Tricuspid valve incompetence 16.08 11.14 174 1051131 19538 78673545
Pneumonia klebsiella 16.07 11.14 118 1051187 4936 78688147
Vocal cord dysfunction 16.07 11.14 29 1051276 586 78692497
Perinephric collection 16.06 11.14 22 1051283 347 78692736
Nephrolithiasis 16.06 11.14 858 1050447 52433 78640650
Sinus arrhythmia 16.06 11.14 4 1051301 2106 78690977
Pleural fibrosis 16.06 11.14 102 1051203 4065 78689018
Metabolic encephalopathy 16.05 11.14 64 1051241 9083 78684000
Endophthalmitis 16.05 11.14 142 1051163 6286 78686797
Graft versus host disease 16.05 11.14 283 1051022 14743 78678340
Endometrial ablation 16.01 11.14 36 1051269 857 78692226
Neck deformity 16.01 11.14 57 1051248 1780 78691303
Bone pain 16 11.14 587 1050718 55155 78637928
Hepatitis toxic 15.97 11.14 27 1051278 5120 78687963
Endocarditis Q fever 15.97 11.14 6 1051299 6 78693077
Cholangitis sclerosing 15.92 11.14 73 1051232 2564 78690519
Extradural abscess 15.92 11.14 50 1051255 1462 78691621
Listeria encephalitis 15.90 11.14 20 1051285 289 78692794
Hepatitis G 15.89 11.14 7 1051298 14 78693069
Prostate cancer 15.88 11.14 326 1050979 32942 78660141
Central nervous system infection 15.86 11.14 47 1051258 1330 78691753
Systemic bacterial infection 15.86 11.14 10 1051295 52 78693031
Chorea 15.85 11.14 6 1051299 2411 78690672
Cancer pain 15.84 11.14 28 1051277 5217 78687866
Apathy 15.82 11.14 103 1051202 12874 78680209
Enterocolitis 15.82 11.14 119 1051186 14393 78678690
High density lipoprotein decreased 15.80 11.14 23 1051282 4632 78688451
Encephalitis brain stem 15.80 11.14 18 1051287 233 78692850
Abnormal faeces 15.79 11.14 161 1051144 7410 78685673
Insomnia 15.74 11.14 2919 1048386 242251 78450832
Pyogenic granuloma 15.70 11.14 26 1051279 489 78692594
Hypersomnia 15.70 11.14 212 1051093 22874 78670209
Bedridden 15.70 11.14 235 1051070 11844 78681239
Ileal stenosis 15.70 11.14 68 1051237 2330 78690753
Blood calcium increased 15.68 11.14 77 1051228 10323 78682760
Throat clearing 15.68 11.14 73 1051232 2581 78690502
Chronic graft versus host disease in liver 15.61 11.14 30 1051275 637 78692446
Chronic myeloid leukaemia 15.58 11.14 92 1051213 3572 78689511
Metabolic disorder 15.56 11.14 65 1051240 9105 78683978
Pancreatitis chronic 15.55 11.14 18 1051287 4001 78689082
Suicidal behaviour 15.55 11.14 12 1051293 3235 78689848
Pleocytosis 15.53 11.14 48 1051257 1391 78691692
Lip oedema 15.46 11.14 38 1051267 6278 78686805
Hepatitis C RNA increased 15.46 11.14 23 1051282 393 78692690
Acute lymphocytic leukaemia recurrent 15.43 11.14 111 1051194 4613 78688470
Viral skin infection 15.40 11.14 12 1051293 92 78692991
Spinal instability 15.40 11.14 24 1051281 428 78692655
Complications of transplanted liver 15.37 11.14 23 1051282 395 78692688
Sciatica 15.37 11.14 559 1050746 32663 78660420
Liver transplant failure 15.32 11.14 13 1051292 114 78692969
Hyperbilirubinaemia 15.31 11.14 229 1051076 24289 78668794
Right ventricular hypertrophy 15.31 11.14 52 1051253 1585 78691498
C3 glomerulopathy 15.29 11.14 10 1051295 56 78693027
Hepatocellular carcinoma 15.27 11.14 64 1051241 8957 78684126
Intervertebral disc space narrowing 15.26 11.14 54 1051251 1681 78691402
Acne 15.26 11.14 468 1050837 26722 78666361
Haemophilus infection 15.25 11.14 65 1051240 2211 78690872
Rhinitis perennial 15.25 11.14 21 1051284 333 78692750
Salmonella bacteraemia 15.25 11.14 20 1051285 302 78692781
Pneumothorax spontaneous 15.23 11.14 48 1051257 1406 78691677
Sinus disorder 15.21 11.14 396 1050909 22068 78671015
Papilloedema 15.20 11.14 137 1051168 6096 78686987
Blood urea decreased 15.19 11.14 11 1051294 3064 78690019
Meningitis coccidioides 15.19 11.14 9 1051296 41 78693042
Renal cell carcinoma stage I 15.19 11.14 9 1051296 41 78693042
Anticonvulsant drug level increased 15.17 11.14 8 1051297 2645 78690438
Porokeratosis 15.17 11.14 18 1051287 244 78692839
Premature labour 15.17 11.14 58 1051247 8332 78684751
Infectious thyroiditis 15.14 11.14 13 1051292 116 78692967
Thyroid gland abscess 15.13 11.14 11 1051294 75 78693008
Blood iron abnormal 15.13 11.14 46 1051259 1321 78691762
Hemiplegia 15.12 11.14 125 1051180 14814 78678269
Glomerulonephritis 15.12 11.14 87 1051218 3346 78689737
Meningitis histoplasma 15.07 11.14 6 1051299 8 78693075
Hypertrophic cardiomyopathy 15.05 11.14 66 1051239 2274 78690809
Pulseless electrical activity 15.02 11.14 117 1051188 14043 78679040
Lactobacillus infection 14.95 11.14 22 1051283 372 78692711
Catheter site erythema 14.91 11.14 29 1051276 5211 78687872
Underdose 14.91 11.14 328 1050977 32823 78660260
Forced expiratory volume 14.91 11.14 12 1051293 97 78692986
Mycobacterium kansasii infection 14.89 11.14 21 1051284 341 78692742
Slow speech 14.89 11.14 7 1051298 2471 78690612
Zoonotic bacterial infection 14.88 11.14 10 1051295 59 78693024
Hypoxic-ischaemic encephalopathy 14.83 11.14 53 1051252 7767 78685316
Malacoplakia gastrointestinal 14.82 11.14 15 1051290 168 78692915
Acquired haemophilia 14.73 11.14 57 1051248 1854 78691229
Chemical peritonitis 14.73 11.14 19 1051286 282 78692801
Skin bacterial infection 14.69 11.14 26 1051279 517 78692566
Bronchial hyperreactivity 14.69 11.14 79 1051226 2961 78690122
Depressive symptom 14.68 11.14 40 1051265 6383 78686700
Autonomic nervous system imbalance 14.64 11.14 24 1051281 4606 78688477
Vulval ulceration 14.63 11.14 17 1051288 225 78692858
Combined immunodeficiency 14.62 11.14 12 1051293 100 78692983
Injection site bruising 14.62 11.14 671 1050634 40331 78652752
Tumour pain 14.59 11.14 6 1051299 2293 78690790
Atlantoaxial instability 14.53 11.14 19 1051286 286 78692797
Optic neuropathy 14.51 11.14 87 1051218 3397 78689686
Myoclonic epilepsy 14.49 11.14 4 1051301 1966 78691117
Isosporiasis 14.49 11.14 15 1051290 173 78692910
Bipolar I disorder 14.44 11.14 5 1051300 2124 78690959
Rectal prolapse 14.44 11.14 62 1051243 2116 78690967
Herpes zoster meningitis 14.42 11.14 15 1051290 174 78692909
Factor V Leiden mutation 14.42 11.14 15 1051290 174 78692909
Gastrointestinal mucormycosis 14.41 11.14 23 1051282 419 78692664
Pulmonary function test increased 14.40 11.14 5 1051300 3 78693080
Hepatic enzyme abnormal 14.39 11.14 162 1051143 7648 78685435
Aplasia pure red cell 14.39 11.14 162 1051143 7648 78685435
Diffuse alveolar damage 14.37 11.14 89 1051216 3515 78689568
Birdshot chorioretinopathy 14.37 11.14 10 1051295 63 78693020
Urinary tract infection 14.36 11.14 3302 1048003 271210 78421873
Skin striae 14.30 11.14 56 1051249 1832 78691251
T-cell type acute leukaemia 14.29 11.14 15 1051290 176 78692907
Skin infection 14.27 11.14 328 1050977 17917 78675166
Pneumonia 14.25 11.14 9205 1042100 651041 78042042
Osteomyelitis 14.24 11.14 549 1050756 32316 78660767
Otorrhoea 14.24 11.14 53 1051252 1692 78691391
Posture abnormal 14.23 11.14 18 1051287 3848 78689235
Perirectal abscess 14.23 11.14 59 1051246 1982 78691101
Haemarthrosis 14.20 11.14 35 1051270 5777 78687306
Lymphadenopathy mediastinal 14.19 11.14 103 1051202 4293 78688790
Therapy change 14.13 11.14 50 1051255 7349 78685734
Sebaceous adenoma 14.10 11.14 8 1051297 33 78693050
Enterobiasis 14.10 11.14 8 1051297 33 78693050
Anticonvulsant drug level decreased 14.09 11.14 4 1051301 1930 78691153
Epstein-Barr virus antigen positive 14.05 11.14 11 1051294 85 78692998
Cytomegalovirus oesophagitis 14.03 11.14 31 1051274 729 78692354
Pulmonary sarcoidosis 14.01 11.14 45 1051260 1332 78691751
Genital herpes simplex 13.98 11.14 21 1051284 362 78692721
Adrenocortical insufficiency acute 13.98 11.14 78 1051227 2965 78690118
Diffuse alopecia 13.98 11.14 36 1051269 937 78692146
Orthostatic intolerance 13.98 11.14 4 1051301 1920 78691163
Rhegmatogenous retinal detachment 13.97 11.14 15 1051290 181 78692902
Symptom recurrence 13.93 11.14 64 1051241 2250 78690833
Pseudomonas aeruginosa meningitis 13.92 11.14 8 1051297 34 78693049
Pneumonia acinetobacter 13.90 11.14 15 1051290 182 78692901
Protein total decreased 13.89 11.14 67 1051238 9025 78684058
Skin fissures 13.87 11.14 108 1051197 12965 78680118
Blood cholesterol 13.86 11.14 29 1051276 656 78692427
Tuberculosis of genitourinary system 13.81 11.14 9 1051296 50 78693033
Drug withdrawal convulsions 13.76 11.14 6 1051299 2214 78690869
Mean cell haemoglobin concentration abnormal 13.75 11.14 14 1051291 158 78692925
Postoperative thoracic procedure complication 13.75 11.14 11 1051294 88 78692995
Acquired apparent mineralocorticoid excess 13.74 11.14 8 1051297 35 78693048
Pneumopericardium 13.72 11.14 15 1051290 185 78692898
Compartment syndrome 13.72 11.14 29 1051276 5053 78688030
Hypovolaemia 13.70 11.14 158 1051147 17533 78675550
Cytomegalovirus enteritis 13.69 11.14 32 1051273 782 78692301
Parathyroid gland enlargement 13.69 11.14 14 1051291 159 78692924
Dysphoria 13.65 11.14 26 1051279 4708 78688375
Laboratory test abnormal 13.64 11.14 274 1051031 27774 78665309
Infective myositis 13.62 11.14 14 1051291 160 78692923
Foot fracture 13.61 11.14 383 1050922 21598 78671485
Euphoric mood 13.59 11.14 54 1051251 7672 78685411
Gastroenteritis Escherichia coli 13.57 11.14 28 1051277 627 78692456
Renal injury 13.57 11.14 150 1051155 16777 78676306
Torus fracture 13.56 11.14 11 1051294 90 78692993
Disseminated varicella zoster vaccine virus infection 13.56 11.14 12 1051293 112 78692971
Cardiac failure acute 13.54 11.14 172 1051133 18757 78674326
Neck mass 13.54 11.14 102 1051203 4302 78688781
Skin toxicity 13.46 11.14 60 1051245 8254 78684829
Myoglobin blood increased 13.44 11.14 13 1051292 3138 78689945
Phaeohyphomycotic brain abscess 13.41 11.14 9 1051296 53 78693030
Herpes simplex colitis 13.41 11.14 8 1051297 37 78693046
Affect lability 13.41 11.14 90 1051215 11169 78681914
Bacterial translocation 13.37 11.14 28 1051277 634 78692449
Herpes zoster meningoradiculitis 13.37 11.14 4 1051301 0 78693083
Nocardia test positive 13.37 11.14 4 1051301 0 78693083
Gambling disorder 13.33 11.14 5 1051300 2021 78691062
Rabies 13.31 11.14 6 1051299 13 78693070
Neurocryptococcosis 13.29 11.14 7 1051298 24 78693059
Foetal exposure during pregnancy 13.28 11.14 36 1051269 5754 78687329
Palindromic rheumatism 13.28 11.14 22 1051283 414 78692669
Gastritis erosive 13.27 11.14 86 1051219 10761 78682322
Vasoplegia syndrome 13.26 11.14 17 1051288 3613 78689470
Abortion spontaneous 13.25 11.14 292 1051013 29215 78663868
Diabetes insipidus 13.22 11.14 31 1051274 5206 78687877
Peritonitis bacterial 13.21 11.14 73 1051232 9494 78683589
Salpingo-oophorectomy unilateral 13.18 11.14 32 1051273 802 78692281
Fracture delayed union 13.18 11.14 59 1051246 2051 78691032
Initial insomnia 13.17 11.14 47 1051258 6891 78686192
Soft tissue sarcoma 13.17 11.14 15 1051290 194 78692889
Lipase increased 13.17 11.14 146 1051159 16320 78676763
Pyelonephritis fungal 13.15 11.14 16 1051289 223 78692860
Graft infection 13.13 11.14 29 1051276 682 78692401
Pulmonary tuberculosis 13.10 11.14 160 1051145 7705 78685378
Hunger 13.08 11.14 119 1051186 5309 78687774
Knee deformity 13.08 11.14 42 1051263 1243 78691840
Refractory cytopenia with unilineage dysplasia 13.06 11.14 34 1051271 891 78692192
Adverse event 13.05 11.14 942 1050363 59272 78633811
Kyphosis 13.05 11.14 70 1051235 2621 78690462
Gastroenteritis viral 13.04 11.14 424 1050881 24407 78668676
Libido decreased 13.03 11.14 32 1051273 5289 78687794
Paraneoplastic pemphigus 13.03 11.14 13 1051292 143 78692940
Dural arteriovenous fistula 13.02 11.14 9 1051296 56 78693027
Medical device site joint infection 13.02 11.14 20 1051285 352 78692731
Disease progression 13.01 11.14 2686 1048619 181676 78511407
Skin burning sensation 13.01 11.14 112 1051193 13160 78679923
Cockroach allergy 13.00 11.14 11 1051294 96 78692987
Q fever 12.99 11.14 17 1051288 256 78692827
Urticaria thermal 12.95 11.14 22 1051283 423 78692660
Osteomyelitis bacterial 12.94 11.14 23 1051282 459 78692624
Pancreas transplant 12.90 11.14 9 1051296 57 78693026
Infusion site extravasation 12.88 11.14 196 1051109 9912 78683171
Infective uveitis 12.88 11.14 7 1051298 26 78693057
Eye disorder 12.88 11.14 402 1050903 23010 78670073
Aortic dissection 12.87 11.14 22 1051283 4153 78688930
Abdominal wall abscess 12.86 11.14 40 1051265 1163 78691920
Application site rash 12.84 11.14 6 1051299 2126 78690957
Fanconi syndrome acquired 12.84 11.14 10 1051295 2684 78690399
Forced expiratory volume abnormal 12.83 11.14 12 1051293 121 78692962
Brain natriuretic peptide increased 12.79 11.14 67 1051238 8833 78684250
Catheter site pain 12.79 11.14 33 1051272 5363 78687720
Chronic granulomatous disease 12.78 11.14 8 1051297 41 78693042
Clostridium difficile colitis 12.77 11.14 534 1050771 31749 78661334
Bacteraemia 12.77 11.14 542 1050763 32282 78660801
Graft thrombosis 12.77 11.14 22 1051283 428 78692655
Cartilage injury 12.70 11.14 47 1051258 1496 78691587
Erythema 12.69 11.14 2675 1048630 220615 78472468
Viral upper respiratory tract infection 12.68 11.14 178 1051127 8848 78684235
Mastitis bacterial 12.66 11.14 9 1051296 59 78693024
Glomerulosclerosis 12.65 11.14 38 1051267 1084 78691999
Incision site pain 12.65 11.14 72 1051233 2758 78690325
Blood chloride increased 12.64 11.14 31 1051274 5125 78687958
Hepatosplenomegaly 12.63 11.14 129 1051176 5940 78687143
Incorrect route of product administration 12.62 11.14 357 1050948 34572 78658511
Peripheral coldness 12.62 11.14 142 1051163 15828 78677255
Central nervous system enteroviral infection 12.60 11.14 10 1051295 79 78693004
Pruritus 12.59 11.14 4846 1046459 389802 78303281
Pain in jaw 12.58 11.14 489 1050816 45662 78647421
Pemphigoid 12.57 11.14 135 1051170 15180 78677903
Myelosuppression 12.56 11.14 420 1050885 39876 78653207
Drug-induced liver injury 12.56 11.14 728 1050577 65389 78627694
Tooth abscess 12.55 11.14 291 1051014 15919 78677164
Genital lesion 12.54 11.14 24 1051281 508 78692575
Meningitis bacterial 12.53 11.14 70 1051235 2662 78690421
Brain oedema 12.53 11.14 246 1051059 25017 78668066
Injury 12.52 11.14 866 1050439 76630 78616453
Segmented hyalinising vasculitis 12.50 11.14 10 1051295 80 78693003
Quality of life decreased 12.50 11.14 200 1051105 10220 78682863
Renal-limited thrombotic microangiopathy 12.48 11.14 13 1051292 151 78692932
Product residue present 12.47 11.14 17 1051288 3519 78689564
Gastric ulcer haemorrhage, obstructive 12.47 11.14 6 1051299 16 78693067
Varices oesophageal 12.46 11.14 39 1051266 5952 78687131
Joint lock 12.46 11.14 79 1051226 3146 78689937
Increased viscosity of bronchial secretion 12.44 11.14 25 1051280 549 78692534
Lennox-Gastaut syndrome 12.44 11.14 15 1051290 207 78692876
Osteomyelitis blastomyces 12.43 11.14 5 1051300 7 78693076
Cervicitis 12.42 11.14 16 1051289 237 78692846
Genitourinary tract infection 12.42 11.14 17 1051288 268 78692815
Arteriospasm coronary 12.42 11.14 46 1051259 6670 78686413
Laryngeal stenosis 12.41 11.14 37 1051268 1051 78692032
Factor XIII deficiency 12.41 11.14 10 1051295 81 78693002
Device alarm issue 12.40 11.14 6 1051299 2083 78691000
Cerebellar infarction 12.40 11.14 18 1051287 3629 78689454
Poor quality product administered 12.38 11.14 18 1051287 3627 78689456
Mineral metabolism disorder 12.38 11.14 18 1051287 301 78692782
Gastric disorder 12.37 11.14 608 1050697 36825 78656258
Physical assault 12.37 11.14 3 1051302 1608 78691475
Potentiating drug interaction 12.34 11.14 67 1051238 8752 78684331
Upper respiratory tract infection 12.33 11.14 1378 1049927 89790 78603293
Eyelid oedema 12.33 11.14 118 1051187 13569 78679514
Skin squamous cell carcinoma metastatic 12.31 11.14 9 1051296 62 78693021
Nodular rash 12.29 11.14 18 1051287 303 78692780
Differential white blood cell count abnormal 12.27 11.14 6 1051299 2071 78691012
Fungal abscess central nervous system 12.24 11.14 12 1051293 129 78692954
Bone infarction 12.24 11.14 23 1051282 480 78692603
Functional gastrointestinal disorder 12.23 11.14 30 1051275 4960 78688123
Glomerulonephritis minimal lesion 12.23 11.14 30 1051275 757 78692326
Anal ulcer 12.22 11.14 43 1051262 1335 78691748
Biliary hamartoma 12.21 11.14 6 1051299 17 78693066
Nephritis haemorrhagic 12.21 11.14 6 1051299 17 78693066
Pigment nephropathy 12.20 11.14 8 1051297 45 78693038
Scrotal ulcer 12.17 11.14 21 1051284 409 78692674
Vesicoureteric reflux 12.17 11.14 12 1051293 130 78692953
Injection site hypersensitivity 12.15 11.14 54 1051251 1871 78691212
Spinal fracture 12.15 11.14 318 1050987 17736 78675347
Skin atrophy 12.12 11.14 122 1051183 5596 78687487
Type 2 lepra reaction 12.12 11.14 15 1051290 213 78692870
Gastrointestinal scarring 12.10 11.14 19 1051286 341 78692742
Presbyacusis 12.10 11.14 68 1051237 2592 78690491
Atypical mycobacterial pneumonia 12.10 11.14 13 1051292 157 78692926
Postoperative wound infection 12.07 11.14 239 1051066 12722 78680361
Urinoma 12.07 11.14 15 1051290 214 78692869
Application site pain 12.06 11.14 28 1051277 4719 78688364
Electrocardiogram PR prolongation 12.05 11.14 3 1051302 1580 78691503
Faeces soft 12.04 11.14 165 1051140 8158 78684925
Squamous cell carcinoma of the vagina 12.04 11.14 5 1051300 8 78693075
Aspergilloma 12.03 11.14 26 1051279 602 78692481
Duodenal ulcer haemorrhage 12.02 11.14 51 1051254 7112 78685971
Vascular rupture 11.98 11.14 49 1051256 1636 78691447
Neutrophilic dermatosis 11.97 11.14 25 1051280 565 78692518
Ossicle disorder 11.96 11.14 7 1051298 31 78693052
Ecthyma 11.94 11.14 29 1051276 727 78692356
Tetany 11.93 11.14 11 1051294 2717 78690366
Acanthoma 11.93 11.14 8 1051297 47 78693036
Prothrombin time shortened 11.92 11.14 15 1051290 3213 78689870
Injection site pain 11.90 11.14 1514 1049791 128324 78564759
Oesophageal infection 11.89 11.14 27 1051278 647 78692436
Carbohydrate antigen 125 increased 11.89 11.14 7 1051298 2177 78690906
Epstein-Barr virus infection reactivation 11.89 11.14 53 1051252 1839 78691244
Growth retardation 11.89 11.14 54 1051251 1889 78691194
Walking aid user 11.88 11.14 194 1051111 9954 78683129
Cerebellar syndrome 11.88 11.14 35 1051270 5445 78687638
Pyelocaliectasis 11.87 11.14 33 1051272 900 78692183
Disseminated large cell lymphoma 11.87 11.14 9 1051296 66 78693017
Tuberculosis liver 11.87 11.14 9 1051296 66 78693017
Vascular purpura 11.85 11.14 14 1051291 3084 78689999
Product preparation error 11.85 11.14 38 1051267 5755 78687328
Vestibular disorder 11.85 11.14 9 1051296 2446 78690637
Mediastinum neoplasm 11.85 11.14 10 1051295 87 78692996
Adrenal suppression 11.84 11.14 43 1051262 1356 78691727
Pericardial haemorrhage 11.84 11.14 26 1051279 4469 78688614
X-ray abnormal 11.83 11.14 123 1051182 5690 78687393
Shoulder arthroplasty 11.83 11.14 79 1051226 3203 78689880
Meningoencephalitis amoebic 11.82 11.14 12 1051293 135 78692948
Acute chest syndrome 11.80 11.14 3 1051302 1558 78691525
Protothecosis 11.80 11.14 8 1051297 48 78693035
Blood cholesterol decreased 11.79 11.14 4 1051301 1721 78691362
Moraxella infection 11.78 11.14 26 1051279 611 78692472
Embolic stroke 11.77 11.14 58 1051247 7768 78685315
Primary immunodeficiency syndrome 11.76 11.14 9 1051296 67 78693016
Food intolerance 11.76 11.14 89 1051216 3759 78689324
Discouragement 11.74 11.14 48 1051257 1602 78691481
Urethral fistula 11.74 11.14 6 1051299 19 78693064
Impaired gastric emptying 11.71 11.14 84 1051221 10269 78682814
Pleomorphism 11.68 11.14 5 1051300 9 78693074
Ventricular hypokinesia 11.64 11.14 73 1051232 9206 78683877
Hypoaesthesia 11.64 11.14 2134 1049171 177218 78515865
Pneumonia escherichia 11.61 11.14 32 1051273 868 78692215
Temporal lobe epilepsy 11.61 11.14 21 1051284 425 78692658
Rash papular 11.61 11.14 211 1051094 21705 78671378
Inspiratory capacity abnormal 11.61 11.14 11 1051294 113 78692970
Injection site nodule 11.58 11.14 20 1051285 3760 78689323
Schizoaffective disorder 11.58 11.14 7 1051298 2145 78690938
Amenorrhoea 11.57 11.14 57 1051248 7635 78685448
Bone marrow oedema 11.57 11.14 49 1051256 1662 78691421
Malignant mediastinal neoplasm 11.57 11.14 43 1051262 1372 78691711
Serositis 11.57 11.14 31 1051274 827 78692256
Coronary artery bypass 11.55 11.14 41 1051264 6021 78687062
Stress 11.55 11.14 1209 1050096 78403 78614680
Areflexia 11.53 11.14 36 1051269 5498 78687585
Ophthalmic herpes simplex 11.53 11.14 28 1051277 702 78692381
Feeding intolerance 11.52 11.14 31 1051274 829 78692254
Cytomegalovirus myocarditis 11.52 11.14 6 1051299 20 78693063
Bacteroides bacteraemia 11.49 11.14 10 1051295 91 78692992
Oral candidiasis 11.47 11.14 489 1050816 29139 78663944
Peripheral T-cell lymphoma unspecified 11.47 11.14 27 1051278 663 78692420
Incorrect dose administered by device 11.45 11.14 31 1051274 4958 78688125
Bunion operation 11.45 11.14 33 1051272 919 78692164
Acute hepatitis B 11.45 11.14 22 1051283 467 78692616
Orbital apex syndrome 11.45 11.14 9 1051296 70 78693013
Breast pain 11.45 11.14 63 1051242 8202 78684881
Injection site mass 11.44 11.14 192 1051113 19992 78673091
Mediastinitis 11.43 11.14 31 1051274 833 78692250
Diffuse idiopathic skeletal hyperostosis 11.42 11.14 8 1051297 51 78693032
Gastrointestinal bacterial infection 11.39 11.14 33 1051272 922 78692161
Oral lichenoid reaction 11.38 11.14 11 1051294 116 78692967
Facial bones fracture 11.35 11.14 32 1051273 5050 78688033
Transitional cell cancer of renal pelvis and ureter metastatic 11.35 11.14 5 1051300 10 78693073
Bartonellosis 11.35 11.14 5 1051300 10 78693073
Pseudomonal sepsis 11.34 11.14 128 1051177 6046 78687037
Organising pneumonia 11.32 11.14 205 1051100 10734 78682349
Internal hernia 11.31 11.14 7 1051298 35 78693048
Orbital myositis 11.31 11.14 13 1051292 170 78692913
Small cell lung cancer recurrent 11.30 11.14 6 1051299 21 78693062
Kaposi sarcoma inflammatory cytokine syndrome 11.30 11.14 6 1051299 21 78693062
Gastritis haemorrhagic 11.29 11.14 11 1051294 2646 78690437
Fungal endocarditis 11.29 11.14 25 1051280 589 78692494
Viral mutation identified 11.29 11.14 21 1051284 3837 78689246
Injury associated with device 11.25 11.14 18 1051287 3488 78689595
Fungaemia 11.24 11.14 101 1051204 4490 78688593
Blood stem cell transplant failure 11.24 11.14 23 1051282 512 78692571
Bronchiolitis 11.23 11.14 94 1051211 4094 78688989
Basal ganglia haemorrhage 11.21 11.14 4 1051301 1667 78691416
Acute myeloid leukaemia recurrent 11.20 11.14 17 1051288 3366 78689717
Graft versus host disease in skin 11.20 11.14 126 1051179 5947 78687136
Wound infection 11.18 11.14 404 1050901 23587 78669496
Hypochloraemia 11.17 11.14 10 1051295 2505 78690578
Fungal tracheitis 11.17 11.14 4 1051301 3 78693080
Endocarditis histoplasma 11.17 11.14 4 1051301 3 78693080
Chronic graft versus host disease oral 11.16 11.14 12 1051293 145 78692938
Multiple injuries 11.16 11.14 18 1051287 3477 78689606
Malacoplakia vesicae 11.16 11.14 9 1051296 73 78693010
Hepatitis viral 11.15 11.14 35 1051270 1023 78692060
Central nervous system fungal infection 11.15 11.14 21 1051284 439 78692644

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07EA03 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC H02AB07 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:37962 adrenergic agents
CHEBI has role CHEBI:50266 Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Lรถffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Thyroiditis indication 82119001 DOID:7166
Autoimmune disease indication 85828009
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Acute lymphoid leukemia indication 91857003 DOID:9952
Chronic lymphoid leukemia, disease indication 92814006
Disorder of skin indication 95320005 DOID:37
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Asthma indication 195967001 DOID:2841
Transplanted organ rejection indication 213148006
Adrenogenital disorder indication 267395000 DOID:0050811
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Prevention of Transplant Rejection indication
Erythroblastic Anemia indication
Systemic Dermatomyositis indication
Diffuse Proliferative Lupus Nephritis indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Pemphigoid off-label use 86142006
Myasthenia gravis off-label use 91637004 DOID:437
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Bell's palsy off-label use 193093009 DOID:12506
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Pure Red Cell Aplasia associated with Chronic Lymphocytic Leukemia off-label use
Metastatic Prostate Carcinoma off-label use
Neuroendocrine Prostate Carcinoma off-label use
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Cluster Headache Prevention off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Ornithine Carbamyltransferase Deficiency contraindication 80908008 DOID:9271
Open-angle glaucoma contraindication 84494001 DOID:1067
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Pregnancy, function contraindication 289908002
Varicella-zoster virus infection contraindication 309465005
Osteopenia contraindication 312894000
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Arginosuccinate Lyase Deficiency contraindication




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Cats Inflammation Indication
Dogs Inflammation Indication
Horses Inflammation Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Meticorten Intervet Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.33 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 8309124 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED RELEASE 1, 2, OR 5 MG PREDNISONE TABLET
1MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 8394407 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
1MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9040085 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
1MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9186332 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
2MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 8394407 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
2MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9040085 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
2MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9186332 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
5MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 8309124 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED RELEASE 1, 2, OR 5 MG PREDNISONE TABLET
5MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 8394407 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
5MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9040085 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
5MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9186332 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
1MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9504699 Aug. 3, 2027 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
2MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9504699 Aug. 3, 2027 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
5MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9504699 Aug. 3, 2027 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
5MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 8168218 Jan. 7, 2028 TREATMENT OF RHEUMATOLOGIC, ALLERGIC, PULMONARY, GASTROINTESTINAL, DERMATOLOGIC DISEASES OR CONDITIONS BY THE USE OF A DELAYED RELEASE 5MG PREDNISONE TABLET

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8 WOMBAT-PK CHEMBL
Sodium/nucleoside cotransporter 1 Transporter Ki 5.77 DRUG MATRIX
Annexin A1 Cytosolic other WOMBAT-PK

External reference:

IDSource
4017876 VUID
N0000146229 NUI
D00473 KEGG_DRUG
4017876 VANDF
C0032952 UMLSCUI
CHEBI:8382 CHEBI
PDN PDB_CHEM_ID
CHEMBL635 ChEMBL_ID
DB00635 DRUGBANK_ID
D011241 MESH_DESCRIPTOR_UI
5865 PUBCHEM_CID
7096 IUPHAR_LIGAND_ID
536 INN_ID
VB0R961HZT UNII
8640 RXNORM
287 MMSL
5351 MMSL
72025 MMSL
d00350 MMSL
002164 NDDF
10312003 SNOMEDCT_US
116602009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0017 TABLET 10 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0017 TABLET 10 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0017 TABLET 10 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0018 TABLET 20 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0018 TABLET 20 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0018 TABLET 20 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0019 TABLET 50 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0019 TABLET 50 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0019 TABLET 50 mg ORAL ANDA 10 sections
PredniSONE Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3721 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 10 sections
PredniSONE Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3721 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 10 sections
PredniSONE Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3721 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-3722 SOLUTION 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-3722 SOLUTION 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-3722 SOLUTION 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4728 TABLET 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4728 TABLET 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4728 TABLET 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4741 TABLET 1 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4741 TABLET 1 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4741 TABLET 1 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4742 TABLET 2.50 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4742 TABLET 2.50 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4742 TABLET 2.50 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8724 TABLET 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8724 TABLET 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8724 TABLET 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8739 TABLET 1 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8739 TABLET 1 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8739 TABLET 1 mg ORAL ANDA 10 sections