prednisone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2253 53-03-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednisone anhydrous
  • prednisone
  • 1,2-dehydrocortisone
  • dehydrocortisone
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
  • Molecular weight: 358.43
  • Formula: C21H26O5
  • CLOGP: 1.66
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 91.67
  • ALOGS: -3.51
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.13 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 3 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 7.97 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.57 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.27 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 21, 1955 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1744.75 10.85 6358 677970 196192 49724604
Completed suicide 1406.18 10.85 97 684231 131792 49789004
Drug ineffective 1332.32 10.85 16882 667446 802451 49118345
Death 816.31 10.85 2014 682314 323365 49597431
Joint swelling 786.35 10.85 5842 678486 239444 49681352
Toxicity to various agents 782.13 10.85 1037 683291 211462 49709334
Contraindicated product administered 736.60 10.85 3964 680364 144994 49775802
Systemic lupus erythematosus 612.29 10.85 3617 680711 137005 49783791
Treatment failure 557.14 10.85 3474 680854 134163 49786633
Intentional overdose 556.32 10.85 89 684239 62415 49858381
Pemphigus 531.47 10.85 3104 681224 117062 49803734
Overdose 529.92 10.85 348 683980 99379 49821417
Arthralgia 524.70 10.85 8583 675745 430119 49490677
Asthma 523.79 10.85 2495 681833 86842 49833954
Colitis ulcerative 487.83 10.85 843 683485 16011 49904785
Therapeutic product effect incomplete 469.42 10.85 2461 681867 89054 49831742
Drug abuse 458.69 10.85 121 684207 59725 49861071
Arthropathy 434.68 10.85 3633 680695 154273 49766523
Swelling 425.21 10.85 4368 679960 196504 49724292
Constipation 415.38 10.85 1215 683113 184493 49736303
Therapeutic product effect decreased 409.57 10.85 3195 681133 132855 49787941
Pain 399.84 10.85 10443 673885 568460 49352336
Electrocardiogram QT prolonged 393.68 10.85 107 684221 51779 49869017
Post transplant lymphoproliferative disorder 383.72 10.85 372 683956 3832 49916964
Drug interaction 380.17 10.85 1402 682926 198219 49722577
Drug intolerance 379.10 10.85 4579 679749 214525 49706271
Condition aggravated 375.71 10.85 5869 678459 291189 49629607
Glossodynia 375.30 10.85 2763 681565 112806 49807990
Loss of personal independence in daily activities 366.20 10.85 1894 682434 68156 49852640
Wheezing 361.46 10.85 1730 682598 60317 49860479
Depressed level of consciousness 355.15 10.85 129 684199 51824 49868972
Hand deformity 354.62 10.85 2446 681882 97753 49823043
Bradycardia 351.52 10.85 218 684110 64208 49856588
Suicide attempt 334.56 10.85 140 684188 51592 49869204
Hyponatraemia 324.68 10.85 498 683830 95641 49825155
Acute kidney injury 316.56 10.85 1799 682529 226259 49694537
Obstructive airways disorder 313.85 10.85 670 683658 14982 49905814
Musculoskeletal stiffness 299.33 10.85 2851 681477 125630 49795166
Fall 298.05 10.85 2993 681335 331939 49588857
Off label use 296.35 10.85 8451 675877 465975 49454821
Dizziness 295.61 10.85 3126 681202 343243 49577553
Synovitis 294.25 10.85 2760 681568 121105 49799691
Seizure 292.11 10.85 733 683595 117141 49803655
Device expulsion 288.12 10.85 28 684300 28794 49892002
Infusion related reaction 287.15 10.85 3530 680798 166027 49754769
Hypotension 287.04 10.85 1934 682394 233535 49687261
Vomiting 286.28 10.85 4447 679881 456311 49464485
Malignant neoplasm progression 272.79 10.85 311 684017 67813 49852983
Nausea 269.42 10.85 7377 676951 698021 49222775
Abdominal discomfort 249.25 10.85 4459 679869 227182 49693614
Cardiac arrest 238.32 10.85 482 683846 83169 49837627
Product use in unapproved indication 236.40 10.85 2501 681827 113318 49807478
Somnolence 236.32 10.85 1184 683144 153801 49766995
Cardio-respiratory arrest 233.70 10.85 230 684098 53662 49867134
Alopecia 233.65 10.85 4630 679698 240417 49680379
Decreased appetite 231.14 10.85 1678 682650 199245 49721551
Anaemia 221.83 10.85 2262 682066 250194 49670602
Sleep disorder due to a general medical condition 220.28 10.85 374 683954 6997 49913799
Intentional product use issue 218.47 10.85 1783 682545 75135 49845661
Peripheral swelling 214.70 10.85 3945 680383 201991 49718805
Loss of consciousness 213.13 10.85 711 683617 103642 49817154
Histoplasmosis disseminated 212.49 10.85 160 684168 1126 49919670
Wound 211.90 10.85 2276 682052 103518 49817278
Hypoglycaemia 207.64 10.85 251 684077 53330 49867466
White blood cell count decreased 207.08 10.85 843 683485 115879 49804917
Cytomegalovirus infection 205.87 10.85 622 683706 17340 49903456
Intentional self-injury 203.17 10.85 34 684294 23078 49897718
Epstein-Barr virus infection 201.18 10.85 349 683979 6648 49914148
Rhabdomyolysis 200.77 10.85 141 684187 38886 49881910
Dehydration 198.39 10.85 1227 683101 151222 49769574
Product use issue 197.96 10.85 2978 681350 146497 49774299
Sinusitis 196.90 10.85 3321 681007 167237 49753559
Osteoporosis 193.43 10.85 1152 683176 43727 49877069
Pericarditis 188.55 10.85 1757 682571 76932 49843864
Cognitive disorder 182.59 10.85 196 684132 43927 49876869
Hepatic function abnormal 180.44 10.85 109 684219 32572 49888224
Sedation 179.19 10.85 95 684233 30515 49890281
Hypokalaemia 177.97 10.85 602 683726 87390 49833406
Anti-cyclic citrullinated peptide antibody positive 173.60 10.85 1585 682743 69002 49851794
Serotonin syndrome 171.20 10.85 60 684268 24653 49896143
Agitation 168.47 10.85 289 684039 53095 49867701
Nocardiosis 167.79 10.85 157 684171 1541 49919255
Drug withdrawal syndrome 166.84 10.85 65 684263 25016 49895780
Productive cough 165.87 10.85 1251 683077 51443 49869353
Respiratory arrest 164.41 10.85 101 684227 29908 49890888
Forced expiratory volume decreased 162.94 10.85 246 684082 4148 49916648
Balance disorder 162.62 10.85 455 683873 70135 49850661
Tremor 161.03 10.85 903 683425 114000 49806796
Discomfort 160.84 10.85 2203 682125 106177 49814619
Aspergillus infection 160.48 10.85 312 684016 6509 49914287
Suicidal ideation 158.69 10.85 318 684010 55067 49865729
Hyperkalaemia 158.57 10.85 253 684075 47836 49872960
Lower respiratory tract infection 158.37 10.85 1976 682352 93225 49827571
Orthostatic hypotension 156.33 10.85 103 684225 29378 49891418
Wrong technique in product usage process 154.56 10.85 324 684004 55186 49865610
Strongyloidiasis 153.43 10.85 112 684216 747 49920049
Hallucination 153.35 10.85 246 684082 46411 49874385
Cushingoid 152.76 10.85 301 684027 6344 49914452
Lactic acidosis 152.07 10.85 136 684192 33219 49887577
Sputum discoloured 151.77 10.85 462 683866 12933 49907863
Syncope 150.08 10.85 799 683529 102203 49818593
Inflammation 149.75 10.85 1297 683031 55615 49865181
Infection 147.01 10.85 3214 681114 169740 49751056
Diarrhoea 143.70 10.85 6502 677826 581974 49338822
Pneumocystis jirovecii pneumonia 143.59 10.85 481 683847 14182 49906614
Kidney transplant rejection 141.90 10.85 219 684109 3768 49917028
Cerebrovascular accident 140.99 10.85 729 683599 93951 49826845
Multiple sclerosis relapse 140.76 10.85 227 684101 42737 49878059
Weight increased 139.75 10.85 3647 680681 198244 49722552
Smooth muscle cell neoplasm 138.78 10.85 101 684227 670 49920126
Hypersensitivity 137.35 10.85 3846 680482 211315 49709481
Full blood count abnormal 136.04 10.85 652 683676 22736 49898060
Neutrophil count decreased 134.67 10.85 261 684067 45765 49875031
Transplant rejection 133.78 10.85 357 683971 9252 49911544
Dysarthria 132.80 10.85 187 684141 37216 49883580
Metabolic acidosis 132.08 10.85 200 684128 38625 49882171
Nasopharyngitis 131.47 10.85 3478 680850 189449 49731347
Dyskinesia 131.39 10.85 110 684218 27751 49893045
Palmar-plantar erythrodysaesthesia syndrome 128.95 10.85 55 684273 20043 49900753
Blood pressure fluctuation 128.67 10.85 878 683450 34945 49885851
Unresponsive to stimuli 126.61 10.85 136 684192 30473 49890323
Lethargy 126.61 10.85 302 684026 49130 49871666
C-reactive protein abnormal 126.40 10.85 724 683604 27085 49893711
Arthritis 126.29 10.85 1757 682571 84964 49835832
Maternal exposure during pregnancy 124.76 10.85 2934 681394 156844 49763952
Polyomavirus-associated nephropathy 122.63 10.85 127 684201 1425 49919371
Ill-defined disorder 120.84 10.85 1200 683128 53454 49867342
Gastrointestinal haemorrhage 119.31 10.85 547 683781 72774 49848022
Trichodysplasia spinulosa 119.23 10.85 78 684250 424 49920372
Histoplasmosis 118 10.85 132 684196 1627 49919169
Confusional state 117.50 10.85 1787 682541 184141 49736655
International normalised ratio increased 116.69 10.85 256 684072 42896 49877900
Neuroleptic malignant syndrome 116.17 10.85 9 684319 11121 49909675
Sopor 115.90 10.85 62 684266 19817 49900979
Disease recurrence 115.49 10.85 558 683770 19523 49901273
Intentional product misuse 115.38 10.85 291 684037 46443 49874353
Red blood cell sedimentation rate increased 114.74 10.85 736 683592 28680 49892116
Poisoning 114.46 10.85 16 684312 12413 49908383
Muscle injury 112.28 10.85 873 683455 36238 49884558
Depression 110.74 10.85 1572 682756 163851 49756945
Cardiac failure congestive 110.29 10.85 678 683650 83704 49837092
Red blood cell sedimentation rate abnormal 109.49 10.85 475 683853 15868 49904928
Product quality issue 108.84 10.85 155 684173 30703 49890093
Muscle spasms 108.42 10.85 1129 683199 124424 49796372
Platelet count decreased 108.20 10.85 857 683471 99869 49820927
Gastrointestinal disorder 108.06 10.85 1837 682491 92619 49828177
Folliculitis 107.42 10.85 902 683426 38323 49882473
Aggression 105.07 10.85 79 684249 21037 49899759
Hyperhidrosis 105.03 10.85 742 683586 88684 49832112
Product substitution issue 102.89 10.85 31 684297 14026 49906770
Neuropathy peripheral 101.28 10.85 829 683499 95928 49824868
Blood pressure systolic increased 100.73 10.85 822 683506 34627 49886169
Varicella zoster virus infection 100.44 10.85 145 684183 2344 49918452
Circulatory collapse 99.29 10.85 75 684253 19925 49900871
Impaired healing 98.42 10.85 1406 682922 68380 49852416
Haematemesis 98.04 10.85 139 684189 27586 49893210
Haemophagocytic lymphohistiocytosis 98.03 10.85 298 684030 8335 49912461
Metastases to bone 97.97 10.85 61 684267 17934 49902862
Mobility decreased 97.40 10.85 1571 682757 78377 49842419
Blood calcium decreased 97.33 10.85 82 684246 20624 49900172
Rheumatoid nodule 96.98 10.85 385 683943 12350 49908446
Product dose omission issue 96.92 10.85 1826 682502 182012 49738784
Disturbance in attention 96.41 10.85 171 684157 31015 49889781
Sensitivity to weather change 96.04 10.85 235 684093 5766 49915030
Metastases to liver 95.26 10.85 79 684249 20025 49900771
Neutropenia 95.21 10.85 1417 682911 146548 49774248
Respiratory disorder 95.09 10.85 735 683593 30452 49890344
Tachycardia 94.98 10.85 876 683452 98887 49821909
Cytomegalovirus viraemia 94.88 10.85 202 684126 4507 49916289
Altered state of consciousness 94.40 10.85 94 684234 21816 49898980
Rheumatoid factor positive 94.39 10.85 1061 683267 48798 49871998
Hepatic enzyme increased 94.19 10.85 2479 681849 134901 49785895
Creatinine renal clearance decreased 92.97 10.85 23 684305 11858 49908938
Blood alkaline phosphatase increased 92.38 10.85 234 684094 37292 49883504
Skin ulcer 91.90 10.85 803 683525 34515 49886281
Dysgeusia 90.98 10.85 249 684079 38667 49882129
Cardiac failure 89.75 10.85 630 683698 75410 49845386
Steroid dependence 88.84 10.85 57 684271 298 49920498
Limb deformity 88.09 10.85 171 684157 3563 49917233
Device dislocation 87.71 10.85 97 684231 21449 49899347
Cough 87.55 10.85 4045 680283 237219 49683577
Respiratory depression 86.98 10.85 27 684301 11983 49908813
Irritable bowel syndrome 86.04 10.85 1069 683259 50372 49870424
Cryptococcosis 85.63 10.85 81 684247 807 49919989
Phaeohyphomycosis 85.12 10.85 48 684280 189 49920607
Renal failure 84.03 10.85 979 683349 105654 49815142
Anxiety 83.75 10.85 1797 682531 175809 49744987
Accidental exposure to product 83.12 10.85 114 684214 22943 49897853
Amnesia 82.80 10.85 293 684035 41967 49878829
Palpitations 81.90 10.85 849 683479 93657 49827139
Gamma-glutamyltransferase increased 79.87 10.85 176 684152 29447 49891349
Melaena 79.75 10.85 151 684177 26713 49894083
Faecal calprotectin increased 78.99 10.85 120 684208 2035 49918761
Knee arthroplasty 78.23 10.85 785 683543 35061 49885735
Duodenal ulcer perforation 77.64 10.85 951 683377 44660 49876136
Adrenal insufficiency 77.07 10.85 389 683939 13854 49906942
Blood creatine phosphokinase increased 76.71 10.85 150 684178 26217 49894579
Respiratory tract congestion 76.28 10.85 387 683941 13812 49906984
Brain abscess 76.19 10.85 107 684221 1684 49919112
Coma 75.36 10.85 455 683873 56424 49864372
Eosinophilic bronchitis 75.19 10.85 58 684270 425 49920371
Oedema peripheral 75.11 10.85 1596 682732 156365 49764431
Dystonia 74.36 10.85 34 684294 11892 49908904
Helicobacter infection 73.55 10.85 1010 683318 48692 49872104
Torsade de pointes 73.39 10.85 34 684294 11801 49908995
Akathisia 72.56 10.85 12 684316 8217 49912579
Medication error 72.29 10.85 248 684080 35856 49884940
Vaccination failure 72.16 10.85 51 684277 321 49920475
Device difficult to use 72.00 10.85 22 684306 9864 49910932
Psoriatic arthropathy 71.75 10.85 961 683367 46071 49874725
BK virus infection 71.74 10.85 135 684193 2746 49918050
Contrast media allergy 71.66 10.85 111 684217 1916 49918880
Disorientation 71.55 10.85 243 684085 35241 49885555
Vaginal haemorrhage 71.14 10.85 140 684188 24411 49896385
Diabetic ketoacidosis 71.07 10.85 82 684246 17790 49903006
Transient ischaemic attack 70.95 10.85 212 684116 31998 49888798
Blood immunoglobulin E increased 70.89 10.85 120 684208 2239 49918557
Hypomagnesaemia 70.65 10.85 128 684200 23028 49897768
Mycobacterial infection 70.36 10.85 97 684231 1499 49919297
Arrhythmia 70.19 10.85 222 684106 32910 49887886
Alanine aminotransferase increased 70.08 10.85 810 683518 87549 49833247
Complications of transplanted kidney 69.94 10.85 114 684214 2059 49918737
Epistaxis 69.65 10.85 542 683786 63412 49857384
Ascites 69.34 10.85 250 684078 35611 49885185
West Nile viral infection 69.02 10.85 50 684278 329 49920467
Cerebral haemorrhage 68.68 10.85 166 684162 26886 49893910
Aspartate aminotransferase increased 68.27 10.85 699 683629 77299 49843497
Polyarthritis 68.07 10.85 249 684079 7678 49913118
Tardive dyskinesia 67.91 10.85 9 684319 7270 49913526
Hip arthroplasty 67.67 10.85 669 683659 29760 49891036
Myocardial infarction 67.21 10.85 825 683503 88202 49832594
Panniculitis 67.13 10.85 260 684068 8243 49912553
Schizophrenia 67.01 10.85 10 684318 7387 49913409
Epilepsy 66.90 10.85 118 684210 21449 49899347
Diffuse large B-cell lymphoma 66.70 10.85 198 684130 5464 49915332
Nasal polyps 66.50 10.85 122 684206 2432 49918364
Withdrawal syndrome 66.45 10.85 84 684244 17506 49903290
Hypothermia 66.43 10.85 40 684288 11976 49908820
Muscle rigidity 66.15 10.85 25 684303 9804 49910992
Full blood count decreased 65.99 10.85 126 684202 22220 49898576
Ventricular tachycardia 65.76 10.85 70 684258 15751 49905045
Atrial fibrillation 65.20 10.85 975 683353 100770 49820026
Subdural haematoma 64.98 10.85 48 684280 12899 49907897
Product prescribing error 64.73 10.85 115 684213 20846 49899950
Urinary retention 64.70 10.85 163 684165 26027 49894769
Septic shock 64.65 10.85 1110 683218 56065 49864731
Delusion 64.56 10.85 31 684297 10538 49910258
Poisoning deliberate 64.53 10.85 14 684314 7898 49912898
Neutropenic sepsis 64.10 10.85 58 684270 14089 49906707
Memory impairment 63.92 10.85 725 683603 78635 49842161
Epidural lipomatosis 63.84 10.85 31 684297 82 49920714
Blood glucose increased 63.74 10.85 636 683692 70688 49850108
Sinus bradycardia 63.46 10.85 51 684277 13132 49907664
Rash 63.44 10.85 6799 677529 430672 49490124
Metastases to central nervous system 63.16 10.85 37 684291 11245 49909551
Blood bilirubin increased 62.84 10.85 222 684106 31816 49888980
Restlessness 62.71 10.85 156 684172 25017 49895779
Paraesthesia 62.50 10.85 1197 683131 119046 49801750
Flushing 62.24 10.85 592 683736 66423 49854373
Ear pain 62.02 10.85 620 683708 27663 49893133
Cytomegalovirus colitis 61.90 10.85 101 684227 1826 49918970
Drug specific antibody 61.83 10.85 98 684230 1727 49919069
Product administration error 61.81 10.85 107 684221 19592 49901204
Diffuse large B-cell lymphoma recurrent 61.58 10.85 91 684237 1504 49919292
Acute myocardial infarction 60.71 10.85 198 684130 29075 49891721
Obliterative bronchiolitis 60.71 10.85 98 684230 1755 49919041
Mydriasis 60.71 10.85 34 684294 10593 49910203
Generalised tonic-clonic seizure 60.26 10.85 170 684158 26140 49894656
Plasma cell myeloma 60.14 10.85 219 684109 31103 49889693
Therapy partial responder 59.97 10.85 211 684117 6380 49914416
Suspected suicide 59.89 10.85 3 684325 5354 49915442
Infection reactivation 59.35 10.85 70 684258 917 49919879
Hallucination, auditory 58.91 10.85 36 684292 10692 49910104
Chronic allograft nephropathy 58.89 10.85 58 684270 610 49920186
Stevens-Johnson syndrome 58.84 10.85 129 684199 21623 49899173
Abnormal behaviour 58.79 10.85 110 684218 19548 49901248
Dementia 58.77 10.85 78 684250 15919 49904877
Parkinsonism 58.72 10.85 23 684305 8824 49911972
Miosis 58.40 10.85 8 684320 6302 49914494
Granuloma skin 57.98 10.85 192 684136 5626 49915170
Frequent bowel movements 57.86 10.85 354 683974 13564 49907232
Accidental overdose 57.80 10.85 110 684218 19423 49901373
Mycobacterium avium complex infection 57.43 10.85 114 684214 2416 49918380
Sleep disorder due to general medical condition, insomnia type 57.17 10.85 664 683664 30783 49890013
Hallucination, visual 56.80 10.85 85 684243 16497 49904299
Blood pressure diastolic abnormal 56.65 10.85 264 684064 9097 49911699
Labelled drug-drug interaction medication error 56.37 10.85 36 684292 10441 49910355
Rebound effect 55.48 10.85 129 684199 3060 49917736
Steroid diabetes 55.43 10.85 66 684262 874 49919922
Cerebral infarction 55.30 10.85 132 684196 21472 49899324
Abnormal dreams 55.03 10.85 29 684299 9348 49911448
Blood parathyroid hormone decreased 54.92 10.85 216 684112 6898 49913898
Foetal exposure during pregnancy 54.72 10.85 188 684140 27171 49893625
Breast cancer 54.27 10.85 348 683980 42542 49878254
Acquired haemophilia 54.23 10.85 64 684264 839 49919957
Thrombocytopenia 53.88 10.85 1314 683014 126359 49794437
Dust allergy 53.69 10.85 51 684277 511 49920285
Bronchiectasis 53.65 10.85 278 684050 10005 49910791
Extrapyramidal disorder 53.63 10.85 48 684280 11722 49909074
Therapeutic reaction time decreased 53.44 10.85 78 684250 1274 49919522
Herpes zoster 53.39 10.85 1294 683034 69492 49851304
Angioedema 53.33 10.85 295 684033 37381 49883415
Jaundice 53.28 10.85 181 684147 26248 49894548
Heart rate increased 53.19 10.85 1395 682933 75855 49844941
Vision blurred 52.70 10.85 747 683581 77900 49842896
Nightmare 52.67 10.85 85 684243 16001 49904795
Neoplasm progression 52.65 10.85 209 684119 28948 49891848
Disseminated cryptococcosis 52.51 10.85 43 684285 347 49920449
Swollen tongue 52.48 10.85 204 684124 28426 49892370
Delirium 52.45 10.85 302 684026 37890 49882906
Foot deformity 52.19 10.85 441 683887 18769 49902027
Sarcoidosis 52.19 10.85 168 684160 4849 49915947
Chest pain 51.91 10.85 1912 682416 174970 49745826
Disability 51.90 10.85 323 684005 12452 49908344
Posterior reversible encephalopathy syndrome 51.89 10.85 363 683965 14565 49906231
Diabetes mellitus 51.89 10.85 942 683386 48091 49872705
Haemoglobin decreased 51.87 10.85 1316 683012 125900 49794896
Deformity 51.83 10.85 229 684099 7711 49913085
Drug reaction with eosinophilia and systemic symptoms 51.80 10.85 203 684125 28221 49892575
Haematoma 51.79 10.85 224 684104 30286 49890510
Cytomegalovirus gastrointestinal infection 51.76 10.85 38 684290 256 49920540
Renal impairment 51.64 10.85 716 683612 74945 49845851
Joint effusion 51.52 10.85 327 684001 12694 49908102
Central nervous system lymphoma 51.44 10.85 77 684251 1288 49919508
Bone density decreased 51.41 10.85 290 684038 10785 49910011
Psychotic disorder 51.40 10.85 139 684189 21673 49899123
Therapeutic response shortened 51.22 10.85 217 684111 7172 49913624
Mucous stools 51.15 10.85 118 684210 2784 49918012
Fluid retention 51.14 10.85 438 683890 50211 49870585
Ventricular fibrillation 50.64 10.85 41 684287 10518 49910278
Crohn's disease 50.61 10.85 160 684168 4573 49916223
Impaired work ability 50.58 10.85 337 683991 13303 49907493
Body temperature increased 50.56 10.85 647 683681 30694 49890102
Hypocalcaemia 50.49 10.85 189 684139 26627 49894169
Drug level below therapeutic 50.10 10.85 137 684191 3603 49917193
Biopsy lung abnormal 49.81 10.85 29 684299 123 49920673
Meningitis cryptococcal 49.59 10.85 69 684259 1076 49919720
Delayed graft function 49.49 10.85 62 684266 868 49919928
Pre-existing disease 49.36 10.85 30 684298 140 49920656
Blister 49.22 10.85 1508 682820 83910 49836886
Mental status changes 49.18 10.85 288 684040 35984 49884812
Breast cancer metastatic 48.76 10.85 41 684287 10323 49910473
Complication of device insertion 48.64 10.85 11 684317 6030 49914766
Incorrect product administration duration 48.37 10.85 33 684295 9242 49911554
Ulcer 48.32 10.85 451 683877 19749 49901047
Epstein-Barr virus associated lymphoproliferative disorder 48.24 10.85 84 684244 1605 49919191
Coronary artery disease 48.20 10.85 222 684106 29504 49891292
Liver function test abnormal 48.16 10.85 376 683952 43963 49876833
Body height below normal 48.12 10.85 91 684237 1858 49918938
Disease progression 48.08 10.85 960 683368 94906 49825890
Joint stiffness 47.77 10.85 623 683705 29685 49891111
Restless legs syndrome 47.50 10.85 89 684239 15808 49904988
Depressed mood 47.28 10.85 268 684060 33755 49887041
Blood urea increased 47.22 10.85 162 684166 23423 49897373
Cataract 46.69 10.85 899 683429 46401 49874395
Liver transplant rejection 46.68 10.85 72 684256 1238 49919558
Complication associated with device 46.53 10.85 79 684249 14576 49906220
Myalgia 46.50 10.85 1302 683026 123017 49797779
Human antichimeric antibody positive 46.42 10.85 77 684251 1412 49919384
Lupus nephritis 46.27 10.85 100 684228 2255 49918541
Osteoporotic fracture 45.98 10.85 119 684209 3026 49917770
Therapeutic response decreased 45.71 10.85 895 683433 46336 49874460
Blood pressure decreased 45.71 10.85 509 683819 55400 49865396
Salivary hypersecretion 45.65 10.85 16 684312 6575 49914221
Candida infection 45.61 10.85 503 683825 23020 49897776
Unintentional medical device removal 45.60 10.85 9 684319 5426 49915370
Immunosuppressant drug level increased 45.45 10.85 117 684211 2965 49917831
Human polyomavirus infection 45.11 10.85 35 684293 259 49920537
Lupus-like syndrome 45.04 10.85 250 684078 9241 49911555
Myoclonus 45.03 10.85 79 684249 14391 49906405
Urinary incontinence 44.95 10.85 212 684116 27996 49892800
Heart transplant rejection 44.90 10.85 42 684286 412 49920384
American trypanosomiasis 44.75 10.85 21 684307 50 49920746
Vasculitis 44.47 10.85 333 683995 13658 49907138
Metastases to lung 44.43 10.85 50 684278 10970 49909826
Hypophagia 44.41 10.85 208 684120 27520 49893276
Tenosynovitis 44.10 10.85 269 684059 10296 49910500
Dysphagia 43.93 10.85 760 683568 76758 49844038
Toxoplasmosis 43.80 10.85 73 684255 1344 49919452
Dry mouth 43.76 10.85 517 683811 55661 49865135
Uterine perforation 43.71 10.85 16 684312 6399 49914397
Coccidioidomycosis 43.55 10.85 56 684272 806 49919990
Hepatic failure 43.41 10.85 257 684071 32026 49888770
Haematotoxicity 42.98 10.85 216 684112 7679 49913117
Epidermodysplasia verruciformis 42.80 10.85 20 684308 47 49920749
Total lung capacity increased 42.79 10.85 51 684277 676 49920120
Coordination abnormal 42.62 10.85 56 684272 11478 49909318
Musculoskeletal pain 42.59 10.85 1278 683050 70899 49849897
Skin exfoliation 42.38 10.85 273 684055 33339 49887457
Blood pressure diastolic decreased 42.34 10.85 379 683949 16402 49904394
Eye infection toxoplasmal 42.24 10.85 33 684295 247 49920549
Visceral leishmaniasis 42.19 10.85 42 684286 448 49920348
Liver disorder 42.15 10.85 312 684016 36910 49883886
Product adhesion issue 42.02 10.85 5 684323 4387 49916409
Pruritus allergic 41.95 10.85 63 684265 1057 49919739
Inappropriate antidiuretic hormone secretion 41.59 10.85 71 684257 13072 49907724
Device use error 41.58 10.85 10 684318 5256 49915540
Substance abuse 41.23 10.85 4 684324 4120 49916676
Renal transplant failure 41.12 10.85 46 684282 567 49920229
Treatment noncompliance 41.09 10.85 239 684089 29911 49890885
Ketoacidosis 41.08 10.85 3 684325 3892 49916904
Device adhesion issue 40.95 10.85 3 684325 3882 49916914
Wrist surgery 40.56 10.85 52 684276 746 49920050
Secondary immunodeficiency 40.53 10.85 64 684264 1124 49919672
Renal graft infection 40.51 10.85 26 684302 136 49920660
Sensitisation 40.48 10.85 75 684253 1507 49919289
Tumour marker increased 40.38 10.85 3 684325 3837 49916959
Bone pain 40.20 10.85 426 683902 46803 49873993
Multiple sclerosis 40.19 10.85 142 684186 20351 49900445
Mental impairment 40.04 10.85 63 684265 11981 49908815
Temperature regulation disorder 39.98 10.85 5 684323 4222 49916574
Aphasia 39.84 10.85 224 684104 28270 49892526
Atrioventricular block first degree 39.73 10.85 17 684311 6184 49914612
Escherichia bacteraemia 39.63 10.85 112 684216 3004 49917792
Granuloma 39.54 10.85 150 684178 4708 49916088
Pseudohyponatraemia 39.51 10.85 17 684311 30 49920766
C-reactive protein increased 39.48 10.85 1178 683150 65296 49855500
Immobile 39.46 10.85 154 684174 4900 49915896
Blood pressure systolic abnormal 39.29 10.85 207 684121 7499 49913297
Wrist deformity 39.26 10.85 80 684248 1729 49919067
Hypogammaglobulinaemia 39.22 10.85 167 684161 5532 49915264
Hepatitis B reactivation 39.17 10.85 87 684241 2000 49918796
Genital haemorrhage 39.07 10.85 20 684308 6554 49914242
Eosinophil count increased 38.89 10.85 228 684100 8602 49912194
Human herpesvirus 8 infection 38.74 10.85 29 684299 202 49920594
Clostridium difficile infection 38.46 10.85 519 683809 24920 49895876
Polyp 38.29 10.85 163 684165 5399 49915397
COVID-19 38.25 10.85 863 683465 45799 49874997
Caesarean section 38.11 10.85 98 684230 15541 49905255
Hypernatraemia 37.91 10.85 19 684309 6302 49914494
Mucocutaneous leishmaniasis 37.69 10.85 34 684294 317 49920479
Secretion discharge 37.57 10.85 244 684084 9547 49911249
Swollen joint count increased 37.06 10.85 335 683993 14538 49906258
Complication of device removal 36.88 10.85 6 684322 4158 49916638
Wheelchair user 36.81 10.85 149 684179 4823 49915973
Polymyalgia rheumatica 36.76 10.85 98 684230 2538 49918258
Alternaria infection 36.32 10.85 28 684300 205 49920591
Ataxia 36.27 10.85 83 684245 13703 49907093
Scleritis 36.27 10.85 111 684217 3116 49917680
Galactorrhoea 36.22 10.85 4 684324 3719 49917077
Lennox-Gastaut syndrome 36.16 10.85 30 684298 247 49920549
Lymphocyte count decreased 36.13 10.85 208 684120 26099 49894697
Unintended pregnancy 36.03 10.85 11 684317 4935 49915861
Ischaemic stroke 35.82 10.85 104 684224 15844 49904952
Lung transplant rejection 35.82 10.85 48 684280 721 49920075
Finger deformity 35.68 10.85 162 684166 5520 49915276
Breath sounds abnormal 35.49 10.85 203 684125 7589 49913207
Exposure to toxic agent 35.41 10.85 4 684324 3654 49917142
Blood creatinine increased 35.15 10.85 773 683555 75387 49845409
Pulmonary fibrosis 35.09 10.85 494 683834 23943 49896853
Application site erythema 35.09 10.85 9 684319 4529 49916267
Upper gastrointestinal haemorrhage 34.98 10.85 106 684222 15929 49904867
Blood sodium decreased 34.84 10.85 157 684171 20990 49899806
Skin necrosis 34.74 10.85 259 684069 10608 49910188
Loose body in joint 34.58 10.85 60 684268 1143 49919653
Hypertonia 34.58 10.85 6 684322 3967 49916829
Poor venous access 34.52 10.85 249 684079 10091 49910705
Pleural effusion 34.43 10.85 838 683490 80616 49840180
Joint injury 34.38 10.85 448 683880 21341 49899455
Hyperprolactinaemia 34.35 10.85 3 684325 3362 49917434
Anaphylactic shock 34.19 10.85 148 684180 20007 49900789
Listeriosis 33.93 10.85 64 684264 1304 49919492
Blood glucose decreased 33.86 10.85 129 684199 18082 49902714
Sensory disturbance 33.80 10.85 68 684260 11761 49909035
Cholecystitis chronic 33.67 10.85 49 684279 9620 49911176
Sexual dysfunction 33.43 10.85 3 684325 3289 49917507
Osteonecrosis of jaw 33.41 10.85 280 684048 32246 49888550
Rheumatic fever 33.31 10.85 362 683966 16505 49904291
Mucormycosis 33.31 10.85 91 684237 2392 49918404
Arthrodesis 33.26 10.85 91 684237 2394 49918402
Drug tolerance decreased 33.17 10.85 225 684103 8935 49911861
Ventricular extrasystoles 33.10 10.85 57 684271 10459 49910337
Vertigo 33.08 10.85 497 683831 51335 49869461
Gastritis 32.95 10.85 286 684042 32697 49888099
Respiratory symptom 32.91 10.85 89 684239 2325 49918471
Bronchial disorder 32.88 10.85 57 684271 1085 49919711
Clonus 32.83 10.85 8 684320 4167 49916629
Therapy responder 32.76 10.85 31 684297 309 49920487
Systemic lupus erythematosus rash 32.76 10.85 73 684255 1682 49919114
Abortion spontaneous 32.69 10.85 384 683944 41388 49879408
Device breakage 32.64 10.85 49 684279 9498 49911298
Human ehrlichiosis 32.52 10.85 23 684305 145 49920651
Device issue 32.47 10.85 149 684179 19823 49900973
Epstein-Barr viraemia 32.42 10.85 49 684279 827 49919969
Temporal lobe epilepsy 32.38 10.85 32 684296 338 49920458
Urticaria 32.38 10.85 2099 682229 127462 49793334
Faecaloma 32.37 10.85 29 684299 7079 49913717
Acanthamoeba infection 32.09 10.85 14 684314 26 49920770
Mycotic allergy 32.01 10.85 47 684281 772 49920024
Bradyphrenia 31.93 10.85 22 684306 6130 49914666
Musculoskeletal disorder 31.83 10.85 367 683961 16982 49903814
Eosinophilic granulomatosis with polyangiitis 31.76 10.85 77 684251 1878 49918918
Rheumatoid lung 31.74 10.85 89 684239 2376 49918420
Parvovirus B19 infection 31.74 10.85 36 684292 451 49920345
Heavy menstrual bleeding 31.59 10.85 106 684222 15431 49905365
Hot flush 31.57 10.85 414 683914 43755 49877041
Uveitis 31.55 10.85 225 684103 9085 49911711
Pre-engraftment immune reaction 31.54 10.85 26 684302 212 49920584
Symptom masked 31.53 10.85 42 684286 627 49920169
Feeling abnormal 31.52 10.85 1381 682947 124111 49796685
Atrioventricular block complete 31.40 10.85 31 684297 7224 49913572
Arthritis bacterial 31.35 10.85 155 684173 5474 49915322
Colectomy 31.26 10.85 80 684248 2020 49918776
Jaundice cholestatic 31.20 10.85 15 684313 5096 49915700
Impaired quality of life 31.10 10.85 163 684165 5893 49914903
Defaecation urgency 31.04 10.85 101 684227 2932 49917864
Toxic epidermal necrolysis 31.01 10.85 162 684166 20830 49899966
Peak expiratory flow rate decreased 30.97 10.85 39 684289 549 49920247
Bronchopulmonary aspergillosis 30.87 10.85 192 684136 7400 49913396
Rhinitis 30.72 10.85 205 684123 8096 49912700
Electrocardiogram QRS complex prolonged 30.67 10.85 17 684311 5327 49915469
Cyanosis 30.60 10.85 104 684224 15080 49905716
Pleural mesothelioma malignant 30.55 10.85 15 684313 41 49920755
Bone swelling 30.50 10.85 57 684271 1153 49919643
Fear 30.45 10.85 98 684230 14451 49906345
Dry skin 30.44 10.85 406 683922 42785 49878011
Acute generalised exanthematous pustulosis 30.43 10.85 46 684282 8892 49911904
Angina pectoris 30.38 10.85 218 684110 25970 49894826
Bedridden 30.37 10.85 224 684104 9143 49911653
Chronic kidney disease 30.21 10.85 368 683960 39403 49881393
JC virus infection 30.03 10.85 72 684256 1743 49919053
Pulmonary embolism 29.89 10.85 1099 683229 100605 49820191
Pregnancy with contraceptive device 29.84 10.85 9 684319 4070 49916726
Sickle cell anaemia with crisis 29.84 10.85 12 684316 4531 49916265
Bronchial polyp 29.76 10.85 17 684311 69 49920727
Multifocal micronodular pneumocyte hyperplasia 29.76 10.85 17 684311 69 49920727
Personality change 29.55 10.85 20 684308 5625 49915171
Blood pressure diastolic increased 29.49 10.85 187 684141 7256 49913540
Hepatosplenic T-cell lymphoma 29.39 10.85 38 684290 550 49920246
Myopathy 29.32 10.85 218 684110 8921 49911875
Bloody discharge 29.22 10.85 55 684273 1119 49919677
Tuberculin test positive 28.99 10.85 102 684226 3084 49917712
Sputum purulent 28.96 10.85 49 684279 914 49919882
Microsporidia infection 28.93 10.85 25 684303 219 49920577
Speech disorder 28.90 10.85 324 684004 35224 49885572
Scleroderma renal crisis 28.86 10.85 27 684301 265 49920531
Haematochezia 28.85 10.85 725 683603 39157 49881639
Abortion incomplete 28.84 10.85 4 684324 3122 49917674
Pulmonary toxicity 28.76 10.85 150 684178 5412 49915384
Bacillary angiomatosis 28.76 10.85 16 684312 61 49920735
Therapy non-responder 28.65 10.85 898 683430 50124 49870672
Irritability 28.61 10.85 246 684082 28180 49892616
Glycosylated haemoglobin increased 28.60 10.85 63 684265 10543 49910253
Toxic skin eruption 28.59 10.85 69 684259 11182 49909614
Visual acuity reduced 28.32 10.85 158 684170 19981 49900815
Presyncope 28.28 10.85 201 684127 23997 49896799
Sinus tachycardia 28.18 10.85 171 684157 21183 49899613
Device occlusion 28.13 10.85 24 684304 5999 49914797
No adverse event 28.12 10.85 304 684024 33274 49887522
Emphysema 28.10 10.85 215 684113 8878 49911918
Calciphylaxis 28.04 10.85 89 684239 2549 49918247
Necrotising retinitis 28.01 10.85 27 684301 276 49920520
Drug screen positive 27.78 10.85 6 684322 3396 49917400
Epstein-Barr virus associated lymphoma 27.77 10.85 33 684295 436 49920360
Lung disorder 27.72 10.85 798 683530 44001 49876795
Blood test abnormal 27.72 10.85 254 684074 11065 49909731
Cutaneous calcification 27.70 10.85 17 684311 81 49920715
Herpes simplex hepatitis 27.67 10.85 28 684300 305 49920491
Coma scale abnormal 27.64 10.85 15 684313 4756 49916040
Panic attack 27.61 10.85 151 684177 19191 49901605
Euglycaemic diabetic ketoacidosis 27.50 10.85 3 684325 2816 49917980
Blood pressure increased 27.40 10.85 2123 682205 131009 49789787
Influenza 27.38 10.85 1477 682851 88061 49832735
Mycobacterium chelonae infection 27.38 10.85 32 684296 415 49920381
Metastases to lymph nodes 27.10 10.85 33 684295 6991 49913805
Pulmonary oedema 27.02 10.85 482 683846 48456 49872340
Psychomotor hyperactivity 26.98 10.85 53 684275 9248 49911548
Respiratory acidosis 26.97 10.85 25 684303 6003 49914793
Lung diffusion test decreased 26.83 10.85 37 684291 572 49920224
Right ventricular failure 26.78 10.85 117 684211 15776 49905020
Encephalopathy 26.73 10.85 309 684019 33402 49887394
Myocardial ischaemia 26.62 10.85 75 684253 11538 49909258
Hypotonia 26.61 10.85 43 684285 8091 49912705
Joint range of motion decreased 26.49 10.85 374 683954 18138 49902658
Adjustment disorder with depressed mood 26.40 10.85 91 684237 2723 49918073
Status epilepticus 26.22 10.85 93 684235 13313 49907483
Immunosuppression 26.06 10.85 181 684147 7245 49913551
Graft loss 26.05 10.85 28 684300 329 49920467
Psychomotor retardation 26.01 10.85 7 684321 3411 49917385
Prothrombin time prolonged 25.95 10.85 50 684278 8788 49912008
Erythema multiforme 25.88 10.85 52 684276 8998 49911798
Blood potassium decreased 25.78 10.85 348 683980 36597 49884199
Episcleritis 25.75 10.85 42 684286 759 49920037
Cerebral toxoplasmosis 25.73 10.85 39 684289 660 49920136
Infective tenosynovitis 25.70 10.85 23 684305 212 49920584
Tractional retinal detachment 25.63 10.85 13 684315 39 49920757
Respiratory tract inflammation 25.60 10.85 34 684294 506 49920290
Tuberculosis 25.58 10.85 228 684100 9855 49910941
Device leakage 25.57 10.85 25 684303 5853 49914943
Apnoea 25.56 10.85 34 684294 6932 49913864
Pallor 25.53 10.85 196 684132 23003 49897793
Oral pain 25.48 10.85 216 684112 24817 49895979
Sudden death 25.42 10.85 52 684276 8939 49911857
Cerebral aspergillosis 25.41 10.85 28 684300 339 49920457
Mood altered 25.39 10.85 88 684240 12685 49908111
Herpes simplex 25.39 10.85 175 684153 6987 49913809
Malacoplakia 25.35 10.85 17 684311 97 49920699
New onset diabetes after transplantation 25.33 10.85 16 684312 81 49920715
Periostitis 25.30 10.85 25 684303 264 49920532
Focal segmental glomerulosclerosis 25.28 10.85 56 684272 1285 49919511
Eosinophil count abnormal 25.07 10.85 31 684297 428 49920368
Nerve injury 25.01 10.85 196 684132 8154 49912642
Product preparation error 24.96 10.85 14 684314 4358 49916438
Multiple-drug resistance 24.82 10.85 7 684321 3307 49917489
Lower respiratory tract congestion 24.75 10.85 72 684256 1964 49918832
Left ventricular dysfunction 24.72 10.85 67 684261 10439 49910357
Long QT syndrome 24.71 10.85 5 684323 2962 49917834
Oropharyngeal pain 24.71 10.85 1288 683040 76513 49844283
Polyomavirus viraemia 24.69 10.85 31 684297 435 49920361
Cholelithiasis 24.61 10.85 363 683965 37610 49883186
Complications of transplanted lung 24.57 10.85 22 684306 203 49920593
Abdominal pain upper 24.52 10.85 1838 682490 157471 49763325
Glomerulosclerosis 24.50 10.85 27 684301 327 49920469
Therapy cessation 24.47 10.85 229 684099 25782 49895014
Haemolytic uraemic syndrome 24.43 10.85 78 684250 2241 49918555
Contusion 24.43 10.85 1797 682531 110386 49810410
Isosporiasis 24.39 10.85 12 684316 33 49920763
Orf 24.38 10.85 11 684317 23 49920773
Immunosuppressant drug level decreased 24.32 10.85 43 684285 832 49919964
Complement factor C3 decreased 24.32 10.85 22 684306 206 49920590
Pseudomonas infection 24.31 10.85 214 684114 9216 49911580
Intermenstrual bleeding 24.25 10.85 34 684294 6780 49914016
Blood prolactin increased 24.25 10.85 6 684322 3093 49917703
Atrial septal defect 24.24 10.85 30 684298 6311 49914485
Babesiosis 24.23 10.85 22 684306 207 49920589
Flatulence 24.15 10.85 268 684060 29190 49891606
Urine output decreased 24.11 10.85 67 684261 10354 49910442
Ejection fraction decreased 24.08 10.85 149 684179 18371 49902425
Cervix disorder 24.07 10.85 31 684297 447 49920349
Cutaneous leishmaniasis 24.05 10.85 15 684313 74 49920722
Serum sickness 23.85 10.85 82 684246 2450 49918346
Disseminated cytomegaloviral infection 23.80 10.85 20 684308 168 49920628
Renal tubular atrophy 23.71 10.85 34 684294 546 49920250
Ammonia increased 23.61 10.85 14 684314 4227 49916569
Asthenia 23.53 10.85 3873 680455 315169 49605627
Pyoderma gangrenosum 23.53 10.85 88 684240 2743 49918053
Product complaint 23.47 10.85 78 684250 11388 49909408
Joint destruction 23.37 10.85 110 684218 3806 49916990
Urinary tract infection 23.34 10.85 2662 681666 221358 49699438
Necrotising herpetic retinopathy 23.29 10.85 15 684313 79 49920717
B-cell lymphoma recurrent 23.28 10.85 28 684300 375 49920421
Thinking abnormal 23.28 10.85 60 684268 9507 49911289
Bronchial wall thickening 23.27 10.85 43 684285 862 49919934
Visual impairment 23.27 10.85 724 683604 67551 49853245
Animal scratch 23.21 10.85 43 684285 864 49919932
Ileostomy 23.14 10.85 49 684279 1089 49919707
Dermatomyositis 23.06 10.85 73 684255 2088 49918708
Diplopia 22.99 10.85 159 684169 19101 49901695
Pneumonia cytomegaloviral 22.98 10.85 68 684260 1873 49918923
Ventricular septal defect 22.98 10.85 13 684315 4028 49916768
Chorioretinitis 22.96 10.85 30 684298 439 49920357
Urticaria thermal 22.94 10.85 19 684309 156 49920640
Bronchopleural fistula 22.93 10.85 21 684307 200 49920596
Pulmonary mass 22.92 10.85 368 683960 18337 49902459
Interstitial lung disease 22.91 10.85 908 683420 52268 49868528
Joint laxity 22.89 10.85 78 684250 2320 49918476
Vital capacity decreased 22.82 10.85 44 684284 912 49919884
Disability assessment scale score increased 22.77 10.85 77 684251 2281 49918515
Device malfunction 22.73 10.85 116 684212 15005 49905791
Mental disorder 22.72 10.85 189 684139 21802 49898994
Skin fragility 22.72 10.85 32 684296 505 49920291
Hepatitis B 22.65 10.85 100 684228 3366 49917430
Somnambulism 22.53 10.85 20 684308 4904 49915892
Perfume sensitivity 22.49 10.85 34 684294 574 49920222
Synovial cyst 22.46 10.85 188 684140 7978 49912818
Philadelphia positive chronic myeloid leukaemia 22.42 10.85 11 684317 30 49920766
Laboratory test abnormal 22.41 10.85 203 684125 23005 49897791
Sciatica 22.34 10.85 410 683918 20972 49899824
Ovarian hyperstimulation syndrome 22.26 10.85 8 684320 3236 49917560
Nodule 22.16 10.85 338 683990 16665 49904131
Fear of injection 22.15 10.85 150 684178 5953 49914843
Infection parasitic 22.07 10.85 24 684304 286 49920510
Skin plaque 22.06 10.85 154 684174 6174 49914622
Shock 22.01 10.85 176 684152 20474 49900322
Exposure during pregnancy 21.98 10.85 1376 682952 119639 49801157
Multiple fractures 21.95 10.85 159 684169 6452 49914344
Humoral immune defect 21.85 10.85 14 684314 73 49920723
Device deployment issue 21.74 10.85 10 684318 3486 49917310
Steroid withdrawal syndrome 21.70 10.85 31 684297 496 49920300
International normalised ratio fluctuation 21.58 10.85 72 684256 2118 49918678
Endocarditis bacterial 21.58 10.85 33 684295 563 49920233
Application site pruritus 21.51 10.85 12 684316 3747 49917049
Amylase increased 21.50 10.85 25 684303 5405 49915391
Hypoglycaemic coma 21.49 10.85 3 684325 2330 49918466
Pulmonary hypertension 21.47 10.85 320 684008 33097 49887699
Femoral neck fracture 21.45 10.85 43 684285 7447 49913349
Urate nephropathy 21.43 10.85 16 684312 111 49920685
Atrioventricular block 21.43 10.85 34 684294 6444 49914352
Glomerular filtration rate decreased 21.37 10.85 83 684245 11569 49909227
Electrolyte imbalance 21.36 10.85 140 684188 17029 49903767
Nasal congestion 21.36 10.85 870 683458 50250 49870546
Rhinorrhoea 21.35 10.85 877 683451 50706 49870090
Upper respiratory fungal infection 21.34 10.85 18 684310 152 49920644
Enterobacter infection 21.27 10.85 65 684263 1823 49918973
Granulomatosis with polyangiitis 21.25 10.85 63 684265 1737 49919059
Disseminated sporotrichosis 21.23 10.85 9 684319 15 49920781
Type 2 diabetes mellitus 21.18 10.85 612 683716 33763 49887033
Head injury 21.11 10.85 215 684113 23805 49896991
Hypomania 20.98 10.85 18 684310 4487 49916309
Encephalitis viral 20.90 10.85 58 684270 1539 49919257
Hypervolaemia 20.89 10.85 232 684096 25267 49895529
Cutaneous malacoplakia 20.87 10.85 9 684319 16 49920780
Elbow deformity 20.84 10.85 53 684275 1333 49919463
Abdominal pain lower 20.70 10.85 191 684137 21565 49899231
Chronic graft versus host disease in liver 20.63 10.85 22 684306 256 49920540
Torus fracture 20.56 10.85 16 684312 119 49920677
Product physical issue 20.55 10.85 17 684311 4315 49916481
Bronchopulmonary aspergillosis allergic 20.52 10.85 48 684280 1143 49919653
Limb mass 20.47 10.85 81 684247 2594 49918202
Allergy to animal 20.47 10.85 39 684289 801 49919995
Face oedema 20.45 10.85 149 684179 17690 49903106
Pain in extremity 20.45 10.85 4084 680244 268781 49652015
Rash maculo-papular 20.42 10.85 246 684082 26395 49894401
Asphyxia 20.41 10.85 26 684302 5401 49915395
General physical health deterioration 20.41 10.85 1653 682675 140781 49780015
Bradypnoea 20.39 10.85 8 684320 3066 49917730
Ankle deformity 20.37 10.85 27 684301 401 49920395
Hepatic cytolysis 20.35 10.85 50 684278 8053 49912743
Faeces discoloured 20.31 10.85 131 684197 15993 49904803
Erythropoiesis abnormal 20.30 10.85 22 684306 261 49920535
Hypertensive crisis 20.29 10.85 100 684228 13054 49907742
Cerebral venous sinus thrombosis 20.29 10.85 59 684269 1609 49919187
Prosthesis user 20.26 10.85 13 684315 68 49920728
Cutaneous coccidioidomycosis 20.21 10.85 9 684319 18 49920778
Chronic graft versus host disease oral 20.21 10.85 15 684313 103 49920693
Sarcoma of skin 20.20 10.85 10 684318 28 49920768
Pyomyositis 20.17 10.85 25 684303 346 49920450
Cholestasis 20.07 10.85 233 684095 25168 49895628
Respiratory tract infection 19.99 10.85 571 683757 31446 49889350
Progressive multifocal leukoencephalopathy 19.97 10.85 240 684088 11217 49909579
Acute pulmonary histoplasmosis 19.94 10.85 16 684312 125 49920671
Night sweats 19.94 10.85 595 683733 32979 49887817
Rhinitis allergic 19.93 10.85 166 684162 7034 49913762
Human bocavirus infection 19.90 10.85 25 684303 351 49920445
Lung hernia 19.90 10.85 6 684322 0 49920796
Pneumonia aspiration 19.88 10.85 297 684031 30707 49890089
Anal fissure 19.85 10.85 89 684239 3016 49917780
Dacryocystitis 19.76 10.85 8 684320 11 49920785
Granulocytopenia 19.74 10.85 25 684303 5206 49915590
Hypoxia 19.72 10.85 533 683795 50590 49870206
Hypertrophic osteoarthropathy 19.71 10.85 10 684318 30 49920766
Subarachnoid haemorrhage 19.61 10.85 77 684251 10699 49910097
Lymphocele 19.58 10.85 37 684291 755 49920041
Nasal oedema 19.57 10.85 38 684290 792 49920004
Petit mal epilepsy 19.55 10.85 10 684318 3279 49917517
Klebsiella infection 19.46 10.85 165 684163 7029 49913767
Polyuria 19.45 10.85 42 684286 7079 49913717
Maternal drugs affecting foetus 19.43 10.85 24 684304 5053 49915743
Toothache 19.42 10.85 141 684187 16753 49904043
Rhonchi 19.42 10.85 72 684256 2235 49918561
Thrombotic microangiopathy 19.41 10.85 193 684135 8598 49912198
Patent ductus arteriosus 19.38 10.85 14 684314 3806 49916990
Tooth infection 19.35 10.85 283 684045 13829 49906967
Myasthenia gravis crisis 19.28 10.85 25 684303 363 49920433
Rhegmatogenous retinal detachment 19.27 10.85 13 684315 75 49920721
Product residue present 19.24 10.85 13 684315 3659 49917137
Sensory loss 19.24 10.85 48 684280 7690 49913106
Blood thyroid stimulating hormone increased 19.19 10.85 33 684295 6059 49914737
Application site pain 19.16 10.85 14 684314 3784 49917012
Hospitalisation 19.09 10.85 738 683590 67199 49853597
Red blood cell count decreased 19.07 10.85 332 683996 33503 49887293
Colitis microscopic 19.04 10.85 37 684291 6483 49914313
Ileus 19.04 10.85 103 684225 13126 49907670
Angiocentric lymphoma 19.03 10.85 30 684298 526 49920270
Blastomycosis 19 10.85 20 684308 229 49920567
Joint warmth 18.96 10.85 51 684277 1328 49919468
Diffuse large B-cell lymphoma refractory 18.96 10.85 43 684285 1003 49919793
Extrasystoles 18.90 10.85 21 684307 4634 49916162
Device related infection 18.89 10.85 184 684144 20551 49900245
Underdose 18.87 10.85 179 684149 20099 49900697
Stress cardiomyopathy 18.78 10.85 50 684278 7837 49912959
Angina unstable 18.78 10.85 39 684289 6667 49914129
Hyperreflexia 18.76 10.85 25 684303 5093 49915703
Impaired gastric emptying 18.75 10.85 58 684270 8660 49912136
Cerebral haematoma 18.74 10.85 10 684318 3201 49917595
Middle insomnia 18.71 10.85 211 684117 9710 49911086
Antinuclear antibody positive 18.66 10.85 147 684181 6125 49914671
Acidosis 18.66 10.85 73 684255 10154 49910642
Hemiparesis 18.65 10.85 177 684151 19871 49900925
Histoplasmosis cutaneous 18.63 10.85 8 684320 14 49920782
Escherichia infection 18.56 10.85 228 684100 10713 49910083
Meningitis coccidioides 18.48 10.85 9 684319 24 49920772
Aphthous ulcer 18.48 10.85 222 684106 10375 49910421
Injection site mass 18.44 10.85 130 684198 15550 49905246
Central nervous system vasculitis 18.42 10.85 37 684291 791 49920005
Blood calcium increased 18.33 10.85 49 684279 7670 49913126
Deep vein thrombosis 18.33 10.85 807 683521 72497 49848299
Neuroendocrine carcinoma of the skin 18.32 10.85 27 684301 445 49920351
Complement factor C4 decreased 18.30 10.85 18 684310 189 49920607
Tongue oedema 18.29 10.85 15 684313 3824 49916972
Electrocardiogram abnormal 18.27 10.85 48 684280 7557 49913239
Hepatocellular injury 18.25 10.85 244 684084 25703 49895093
Hypothyroidism 18.24 10.85 338 683990 33787 49887009
Muscle twitching 18.12 10.85 128 684200 15303 49905493
Pulse absent 18.10 10.85 23 684305 4783 49916013
Segmental diverticular colitis 18.03 10.85 15 684313 124 49920672
Porokeratosis 18.03 10.85 15 684313 124 49920672
Pulmonary function test decreased 17.96 10.85 92 684236 3296 49917500
Lymph node calcification 17.95 10.85 19 684309 219 49920577
Dysuria 17.95 10.85 274 684054 28230 49892566
Ageusia 17.90 10.85 88 684240 11495 49909301
Product dispensing error 17.84 10.85 61 684267 8830 49911966
Libido decreased 17.83 10.85 5 684323 2371 49918425
Embedded device 17.82 10.85 8 684320 2829 49917967
Schizoaffective disorder 17.80 10.85 4 684324 2202 49918594
Acute lymphocytic leukaemia recurrent 17.77 10.85 63 684265 1912 49918884
Herpes virus infection 17.74 10.85 120 684208 4761 49916035
Immunoglobulins decreased 17.73 10.85 41 684287 969 49919827
Sporotrichosis 17.65 10.85 8 684320 17 49920779
Bronchitis 17.64 10.85 1637 682691 102522 49818274
Application site rash 17.61 10.85 5 684323 2352 49918444
Abortion induced 17.50 10.85 66 684262 9278 49911518
Pain in jaw 17.45 10.85 391 683937 38037 49882759
Low density lipoprotein increased 17.41 10.85 31 684297 5615 49915181
Candida pneumonia 17.39 10.85 14 684314 110 49920686
Legionella infection 17.37 10.85 25 684303 403 49920393
Renal injury 17.34 10.85 59 684269 8552 49912244
Abdominal abscess 17.33 10.85 103 684225 3905 49916891
Obsessive-compulsive disorder 17.26 10.85 12 684316 3328 49917468
Kidney fibrosis 17.25 10.85 54 684274 1535 49919261
Latent tuberculosis 17.23 10.85 68 684260 2175 49918621
Oral herpes 17.20 10.85 384 683944 20341 49900455
Mantle cell lymphoma recurrent 17.19 10.85 14 684314 112 49920684
Paranasal sinus discomfort 17.18 10.85 83 684245 2903 49917893
Haemorrhage 17.18 10.85 571 683757 52870 49867926
Amenorrhoea 17.17 10.85 58 684270 8426 49912370
Diabetic neuropathy 17.15 10.85 14 684314 3577 49917219
Bronchial neoplasm 17.14 10.85 25 684303 408 49920388
Cardiogenic shock 17.07 10.85 132 684196 15467 49905329
Mycobacterium fortuitum infection 17.06 10.85 9 684319 30 49920766
Bronchial obstruction 17.03 10.85 47 684281 1243 49919553
Basal cell carcinoma 17.01 10.85 425 683903 22931 49897865
Cerebellar syndrome 16.97 10.85 12 684316 3299 49917497
Rales 16.95 10.85 208 684120 9770 49911026
Blood loss anaemia 16.91 10.85 55 684273 8084 49912712
Enterocolitis 16.90 10.85 40 684288 6527 49914269
B-cell lymphoma stage IV 16.89 10.85 6 684322 4 49920792
Dyspepsia 16.86 10.85 824 683504 73273 49847523
Drug specific antibody present 16.85 10.85 90 684238 3278 49917518
Arthritis infective 16.83 10.85 131 684197 5438 49915358
Tendon rupture 16.83 10.85 159 684169 6985 49913811
Extradural abscess 16.79 10.85 35 684293 769 49920027
Rectal prolapse 16.79 10.85 57 684271 1692 49919104
Infusion site pain 16.75 10.85 98 684230 12248 49908548
Muscle spasticity 16.75 10.85 326 684002 16858 49903938
Metabolic alkalosis 16.70 10.85 8 684320 2723 49918073
Nodular rash 16.60 10.85 17 684311 188 49920608
Rash erythematous 16.57 10.85 352 683976 34500 49886296
Eye abscess 16.53 10.85 14 684314 119 49920677
Incontinence 16.53 10.85 74 684254 9911 49910885
Dactylitis 16.44 10.85 59 684269 1802 49918994
Ureaplasma infection 16.43 10.85 27 684301 491 49920305
Pneumocystis jirovecii infection 16.38 10.85 46 684282 1229 49919567
Hypoaldosteronism 16.37 10.85 15 684313 143 49920653
Pneumatosis intestinalis 16.35 10.85 64 684264 2039 49918757
Giant cell arteritis 16.33 10.85 58 684270 1762 49919034
Drug level increased 16.31 10.85 174 684154 19094 49901702
Menstruation irregular 16.29 10.85 37 684291 6125 49914671
Mouth ulceration 16.20 10.85 495 683833 27529 49893267
Osteonecrosis 16.18 10.85 409 683919 22108 49898688
Epstein-Barr virus test positive 16.15 10.85 28 684300 533 49920263
Graft versus host disease in lung 16.15 10.85 22 684306 336 49920460
Human herpesvirus 6 infection 16.14 10.85 74 684254 2532 49918264
Therapeutic product effect delayed 16.12 10.85 62 684266 1959 49918837
Ejection fraction 16.12 10.85 44 684284 1156 49919640
Broncholithiasis 16.05 10.85 15 684313 147 49920649
Neck deformity 16.04 10.85 61 684267 1917 49918879
Growth retardation 15.98 10.85 41 684287 1037 49919759
Heparin-induced thrombocytopenia 15.97 10.85 18 684310 3947 49916849
Mycobacterium abscessus infection 15.94 10.85 27 684301 504 49920292
Cellulitis gangrenous 15.93 10.85 10 684318 50 49920746
Social avoidant behaviour 15.90 10.85 9 684319 2788 49918008
Nystagmus 15.86 10.85 32 684296 5529 49915267
Eye movement disorder 15.86 10.85 23 684305 4522 49916274
Lip swelling 15.84 10.85 237 684091 24499 49896297
Thirst 15.84 10.85 82 684246 10568 49910228
Neurosarcoidosis 15.83 10.85 16 684312 174 49920622
Pulseless electrical activity 15.81 10.85 44 684284 6797 49913999
Frustration tolerance decreased 15.81 10.85 131 684197 5543 49915253
Arteriosclerosis 15.80 10.85 66 684262 9011 49911785
B-cell lymphoma 15.78 10.85 81 684247 2904 49917892
Scedosporium infection 15.75 10.85 24 684304 408 49920388
Pelvic pain 15.75 10.85 88 684240 11125 49909671
Immunodeficiency 15.73 10.85 285 684043 14543 49906253
Renal transplant 15.68 10.85 44 684284 1175 49919621
Pancreatitis acute 15.65 10.85 227 684101 23585 49897211
Body temperature decreased 15.63 10.85 310 684018 16085 49904711
Acute hepatic failure 15.63 10.85 136 684192 15541 49905255
Dialysis 15.59 10.85 70 684258 9368 49911428
Kaposi's sarcoma 15.58 10.85 15 684313 153 49920643
Acarodermatitis 15.56 10.85 37 684291 891 49919905
Hypovolaemic shock 15.54 10.85 29 684299 5159 49915637
Abdominal wall infection 15.44 10.85 12 684316 89 49920707
Erythema nodosum 15.43 10.85 98 684230 3805 49916991
Asthma-chronic obstructive pulmonary disease overlap syndrome 15.40 10.85 25 684303 450 49920346
Perinephric abscess 15.36 10.85 15 684313 156 49920640
Smoke sensitivity 15.35 10.85 21 684307 322 49920474
Alcohol use 15.34 10.85 4 684324 1991 49918805
Pedal pulse abnormal 15.32 10.85 14 684314 133 49920663
Affect lability 15.31 10.85 66 684262 8932 49911864
Intestinal resection 15.25 10.85 68 684260 2299 49918497
Throat clearing 15.18 10.85 43 684285 1155 49919641
Blood bicarbonate decreased 15.16 10.85 9 684319 2716 49918080
Renal disorder 15.15 10.85 271 684057 27234 49893562
Disseminated coccidioidomycosis 15.14 10.85 9 684319 40 49920756
Small for dates baby 15.14 10.85 15 684313 3490 49917306
Bronchial secretion retention 15.14 10.85 50 684278 1463 49919333
Hypoaesthesia 15.14 10.85 1498 682830 125759 49795037
Dissociation 15.13 10.85 6 684322 2285 49918511
Metastatic squamous cell carcinoma 15.11 10.85 17 684311 211 49920585
Respiratory rate increased 15.10 10.85 227 684101 11158 49909638
Hepatitis acute 15.06 10.85 56 684272 7905 49912891
Bronchial haemorrhage 15.03 10.85 26 684302 494 49920302
Retching 14.95 10.85 107 684221 12755 49908041
Lupus vasculitis 14.94 10.85 25 684303 462 49920334
Anhedonia 14.92 10.85 72 684256 9452 49911344
T-cell lymphoma 14.91 10.85 29 684299 605 49920191
Emphysematous pyelonephritis 14.85 10.85 15 684313 163 49920633
Nephrolithiasis 14.85 10.85 592 683736 34101 49886695
Headache 14.85 10.85 6406 677922 500129 49420667
Oesophageal candidiasis 14.83 10.85 117 684211 4877 49915919
Drug abuser 14.83 10.85 10 684318 2818 49917978
Bundle branch block right 14.78 10.85 25 684303 4620 49916176
X-ray abnormal 14.75 10.85 73 684255 2579 49918217
Moraxella infection 14.75 10.85 21 684307 335 49920461
Inappropriate schedule of product administration 14.69 10.85 1145 683183 70686 49850110
Aplastic anaemia 14.69 10.85 54 684274 7649 49913147
Coronary artery stenosis 14.67 10.85 22 684306 4267 49916529
Lung abscess 14.63 10.85 51 684277 1535 49919261
Substance-induced psychotic disorder 14.62 10.85 52 684276 1581 49919215
Cardiac disorder 14.59 10.85 456 683872 42523 49878273
Metabolic disorder 14.58 10.85 31 684297 5255 49915541
Leiomyosarcoma metastatic 14.53 10.85 6 684322 9 49920787
Donor specific antibody present 14.51 10.85 13 684315 120 49920676
Systemic mycosis 14.51 10.85 40 684288 1057 49919739
Inflammatory bowel disease 14.50 10.85 88 684240 3362 49917434
Skin fissures 14.49 10.85 64 684264 8604 49912192
Epstein Barr virus positive mucocutaneous ulcer 14.48 10.85 22 684306 373 49920423
Injection site pain 14.47 10.85 1298 683030 109726 49811070
Hepatic encephalopathy 14.44 10.85 74 684254 9562 49911234
Coagulopathy 14.41 10.85 164 684164 17780 49903016
Complications of bone marrow transplant 14.40 10.85 24 684304 442 49920354
Quality of life decreased 14.39 10.85 139 684189 6144 49914652
Weight fluctuation 14.39 10.85 154 684174 6994 49913802
Pulmonary cavitation 14.37 10.85 30 684298 660 49920136
Oesophageal dilatation 14.32 10.85 20 684308 313 49920483
Blood potassium increased 14.32 10.85 147 684181 16251 49904545
Grip strength decreased 14.31 10.85 237 684091 11884 49908912
Faecal volume decreased 14.31 10.85 14 684314 146 49920650
Neck mass 14.30 10.85 86 684242 3275 49917521
Salpingo-oophorectomy unilateral 14.29 10.85 26 684302 515 49920281
Conjunctival irritation 14.28 10.85 5 684323 3 49920793
Alcohol abuse 14.27 10.85 4 684324 1897 49918899
COVID-19 pneumonia 14.26 10.85 175 684153 8220 49912576
Taste disorder 14.20 10.85 61 684267 8263 49912533
Activated partial thromboplastin time prolonged 14.20 10.85 42 684286 6360 49914436
Salmonellosis 14.19 10.85 35 684293 863 49919933
Eructation 14.19 10.85 49 684279 7072 49913724
Pulmonary aplasia 14.15 10.85 6 684322 10 49920786
Systemic bacterial infection 14.15 10.85 6 684322 10 49920786
Fibromyalgia 14.15 10.85 744 683584 44234 49876562
Colitis ischaemic 14.11 10.85 73 684255 9410 49911386
Cholecystitis acute 14.09 10.85 49 684279 7057 49913739
Disseminated mycobacterium avium complex infection 14.09 10.85 8 684320 32 49920764
Walking aid user 14.09 10.85 141 684187 6292 49914504
Hallucinations, mixed 14.08 10.85 21 684307 4082 49916714
Endometrial ablation 14.03 10.85 34 684294 829 49919967
Viraemia 14.03 10.85 39 684289 1036 49919760
Diffuse alveolar damage 14.03 10.85 33 684295 789 49920007
Urinary tract candidiasis 14.02 10.85 25 684303 487 49920309
Urine ketone body present 14.01 10.85 7 684321 2326 49918470
Mite allergy 13.99 10.85 25 684303 488 49920308
Atrioventricular block second degree 13.98 10.85 17 684311 3604 49917192
Fusarium infection 13.98 10.85 26 684302 524 49920272
Carbohydrate antigen 125 increased 13.94 10.85 8 684320 2459 49918337
Polydipsia 13.93 10.85 13 684315 3111 49917685
Squamous cell carcinoma 13.88 10.85 163 684165 7576 49913220
Intervertebral disc compression 13.87 10.85 36 684292 917 49919879
Sinus pain 13.85 10.85 64 684264 2197 49918599
Immune system disorder 13.83 10.85 171 684157 8046 49912750
Fistula 13.83 10.85 171 684157 8047 49912749
Sinusitis fungal 13.83 10.85 44 684284 1262 49919534
Joint dislocation reduction 13.80 10.85 6 684322 11 49920785
Adrenal suppression 13.80 10.85 34 684294 838 49919958
Feeling hot 13.78 10.85 414 683914 38788 49882008
Oedematous kidney 13.70 10.85 5 684323 4 49920792
Nephrectomy 13.68 10.85 33 684295 802 49919994
Expired product administered 13.68 10.85 33 684295 5349 49915447
Abscess 13.65 10.85 270 684058 14002 49906794
Genital herpes simplex 13.65 10.85 15 684313 181 49920615
Bunion operation 13.62 10.85 40 684288 1097 49919699
Osteomyelitis bacterial 13.59 10.85 15 684313 182 49920614
Haemorrhage subcutaneous 13.57 10.85 10 684318 2691 49918105
Premature labour 13.57 10.85 95 684233 11381 49909415
Breast cancer recurrent 13.55 10.85 19 684309 3789 49917007
Blood pressure inadequately controlled 13.55 10.85 24 684304 4356 49916440
Perinephric collection 13.55 10.85 12 684316 109 49920687
Rhodococcus infection 13.51 10.85 11 684317 88 49920708
Cardiac failure chronic 13.47 10.85 17 684311 3546 49917250
Gastroenteritis norovirus 13.45 10.85 53 684275 1694 49919102
Tinnitus 13.42 10.85 284 684044 27848 49892948
Disseminated tuberculosis 13.40 10.85 69 684259 2477 49918319
Chronic graft versus host disease in skin 13.39 10.85 29 684299 655 49920141
Enuresis 13.38 10.85 6 684322 2123 49918673
Localised infection 13.38 10.85 445 683883 25040 49895756
Encephalitis brain stem 13.38 10.85 12 684316 111 49920685
Injection site hypersensitivity 13.37 10.85 54 684274 1746 49919050
Skin lesion 13.35 10.85 464 683864 26263 49894533
Tumour necrosis factor receptor-associated periodic syndrome 13.34 10.85 7 684321 23 49920773
Acute biphenotypic leukaemia 13.33 10.85 9 684319 52 49920744
Reversible airways obstruction 13.30 10.85 37 684291 983 49919813
Transfusion 13.29 10.85 111 684217 12794 49908002
Soft tissue neoplasm 13.27 10.85 4 684324 0 49920796
Bordetella infection 13.27 10.85 4 684324 0 49920796
Herpes zoster meningoradiculitis 13.27 10.85 4 684324 0 49920796
Paracoccidioides infection 13.27 10.85 4 684324 0 49920796
Duodenal ulcer 13.25 10.85 47 684281 6728 49914068
Pericardial effusion 13.20 10.85 255 684073 25334 49895462
Colectomy total 13.18 10.85 13 684315 137 49920659
Dysphoria 13.17 10.85 28 684300 4746 49916050
Disseminated blastomycosis 13.16 10.85 6 684322 13 49920783
Upper-airway cough syndrome 13.16 10.85 175 684153 8375 49912421
Forced vital capacity decreased 13.14 10.85 35 684293 906 49919890
Antibody test positive 13.13 10.85 64 684264 2247 49918549
Peptic ulcer haemorrhage 13.10 10.85 37 684291 992 49919804
Pneumonia legionella 13.08 10.85 44 684284 1300 49919496
Diarrhoea haemorrhagic 13.04 10.85 160 684168 7515 49913281
Bone disorder 13.00 10.85 339 683989 18413 49902383
Heart rate decreased 12.99 10.85 611 683717 35886 49884910
Blood chloride decreased 12.94 10.85 30 684298 4931 49915865
Alcoholism 12.94 10.85 3 684325 1617 49919179
Chronic graft versus host disease in eye 12.94 10.85 11 684317 94 49920702
Factor XIII deficiency 12.89 10.85 10 684318 74 49920722
Malignant anorectal neoplasm 12.87 10.85 6 684322 14 49920782
Aspiration 12.85 10.85 73 684255 9191 49911605
Ovarian cyst 12.83 10.85 124 684204 13872 49906924
Anger 12.83 10.85 95 684233 11238 49909558
Respiratory tract infection fungal 12.82 10.85 21 684307 381 49920415
Avian influenza 12.82 10.85 9 684319 56 49920740
Herpes simplex oesophagitis 12.81 10.85 12 684316 118 49920678
Blood thyroid stimulating hormone decreased 12.78 10.85 23 684305 4149 49916647
Subdural haemorrhage 12.78 10.85 11 684317 2738 49918058
Acute hepatitis B 12.77 10.85 19 684309 316 49920480
Autoimmune disorder 12.75 10.85 130 684198 5830 49914966
Genitourinary tract infection 12.75 10.85 15 684313 196 49920600
Cytomegalovirus oesophagitis 12.75 10.85 15 684313 196 49920600
Diabetic retinopathy 12.73 10.85 7 684321 2203 49918593
Blood triglycerides increased 12.72 10.85 95 684233 11217 49909579
Disseminated large cell lymphoma 12.69 10.85 9 684319 57 49920739
Psychomotor skills impaired 12.69 10.85 6 684322 2058 49918738
Hyperaesthesia 12.68 10.85 62 684266 8111 49912685
Acute hepatitis C 12.68 10.85 10 684318 76 49920720
Ophthalmic herpes zoster 12.68 10.85 51 684277 1646 49919150
Cytomegalovirus chorioretinitis 12.66 10.85 47 684281 1460 49919336
Nasal turbinate hypertrophy 12.65 10.85 28 684300 642 49920154
Spirometry abnormal 12.63 10.85 15 684313 198 49920598
Perihepatic abscess 12.59 10.85 6 684322 15 49920781
Suicidal behaviour 12.58 10.85 8 684320 2326 49918470
Symptom recurrence 12.55 10.85 29 684299 685 49920111
Oxygen saturation decreased 12.52 10.85 1152 683176 72096 49848700
Abscess limb 12.49 10.85 100 684228 4187 49916609
Accidental death 12.49 10.85 4 684324 1740 49919056
Lymphoproliferative disorder 12.48 10.85 74 684254 2803 49917993
Disseminated intravascular coagulation 12.47 10.85 160 684168 16975 49903821
Cancer pain 12.46 10.85 10 684318 2577 49918219
Lacunar infarction 12.45 10.85 14 684314 3073 49917723
Primary immunodeficiency syndrome 12.44 10.85 8 684320 42 49920754
Ileal stenosis 12.44 10.85 46 684282 1426 49919370
Blood urea decreased 12.44 10.85 7 684321 2175 49918621
Breast pain 12.43 10.85 56 684272 7488 49913308
Loss of therapeutic response 12.43 10.85 14 684314 174 49920622
Incorrect dosage administered 12.40 10.85 51 684277 1663 49919133
Obstruction 12.38 10.85 59 684269 2052 49918744
Erythema 12.38 10.85 1763 682565 144651 49776145
Nervousness 12.37 10.85 282 684046 27369 49893427
Metastases to spine 12.36 10.85 12 684316 2819 49917977
Fryns syndrome 12.33 10.85 9 684319 60 49920736
Urinary tract infection viral 12.33 10.85 7 684321 28 49920768
Tendon disorder 12.32 10.85 118 684210 5204 49915592
Meningitis histoplasma 12.30 10.85 5 684323 7 49920789
Chromaturia 12.25 10.85 132 684196 14458 49906338
Extrapulmonary tuberculosis 12.25 10.85 18 684310 296 49920500
Birdshot chorioretinopathy 12.22 10.85 9 684319 61 49920735
Faecal calprotectin abnormal 12.22 10.85 9 684319 61 49920735
Panophthalmitis 12.22 10.85 9 684319 61 49920735
Gouty tophus 12.21 10.85 13 684315 151 49920645
Body temperature fluctuation 12.20 10.85 56 684272 1917 49918879
Genital lesion 12.19 10.85 15 684313 206 49920590
Unevaluable event 12.17 10.85 504 683824 45562 49875234
Cyst 12.15 10.85 232 684096 11955 49908841
Cardiovascular disorder 12.14 10.85 87 684241 10367 49910429
Mania 12.12 10.85 92 684236 10824 49909972
Complications of transplant surgery 12.08 10.85 13 684315 153 49920643
Pancreas transplant 12.07 10.85 6 684322 17 49920779
Oedema 12.05 10.85 802 683526 69379 49851417
Clubbing 11.99 10.85 17 684311 270 49920526
Needle issue 11.99 10.85 54 684274 7221 49913575
Anovulatory cycle 11.98 10.85 12 684316 129 49920667
Drooling 11.93 10.85 17 684311 3367 49917429
Anal abscess 11.92 10.85 90 684238 3701 49917095
Bacterial translocation 11.89 10.85 13 684315 156 49920640
Intestinal fibrosis 11.84 10.85 12 684316 131 49920665
Metabolic encephalopathy 11.79 10.85 33 684295 5088 49915708
Herpes zoster cutaneous disseminated 11.77 10.85 12 684316 132 49920664
Anal incontinence 11.76 10.85 99 684229 11391 49909405
Gastrosplenic fistula 11.75 10.85 8 684320 47 49920749
Renal tubular injury 11.75 10.85 20 684308 375 49920421
Injection site induration 11.74 10.85 66 684262 8331 49912465
Chronic obstructive pulmonary disease 11.63 10.85 856 683472 52579 49868217
Pseudopolyp 11.62 10.85 16 684312 247 49920549
Intestinal anastomosis 11.61 10.85 18 684310 311 49920485
Pleural fibrosis 11.59 10.85 82 684246 3302 49917494
Pleomorphism 11.56 10.85 5 684323 9 49920787
Folate deficiency 11.54 10.85 6 684322 1949 49918847
Eosinophilic pneumonia chronic 11.51 10.85 13 684315 162 49920634
Clostridium test positive 11.50 10.85 57 684271 2015 49918781
Hepatic enzyme abnormal 11.46 10.85 108 684220 4741 49916055
Intestinal stenosis 11.45 10.85 66 684262 2474 49918322
Back pain 11.43 10.85 2719 681609 217311 49703485
Blood lactic acid increased 11.43 10.85 38 684290 5547 49915249
Soft tissue injury 11.41 10.85 45 684283 1439 49919357
Abnormal loss of weight 11.39 10.85 33 684295 5031 49915765
Tachyarrhythmia 11.39 10.85 24 684304 4081 49916715
Prophylaxis against transplant rejection 11.37 10.85 6 684322 20 49920776
Pleural thickening 11.37 10.85 67 684261 2532 49918264
Humidity intolerance 11.37 10.85 17 684311 284 49920512
Language disorder 11.30 10.85 5 684323 1783 49919013
Androgenetic alopecia 11.23 10.85 12 684316 140 49920656
Therapeutic response delayed 11.23 10.85 24 684304 537 49920259
Cold sweat 11.21 10.85 91 684237 10553 49910243
Viral mutation identified 11.21 10.85 4 684324 1625 49919171
Ectopic pregnancy 11.20 10.85 9 684319 2318 49918478
Enterovirus infection 11.19 10.85 28 684300 697 49920099
Cogwheel rigidity 11.18 10.85 5 684323 1772 49919024
Bone marrow granuloma 11.16 10.85 6 684322 21 49920775
Neoplasm of appendix 11.15 10.85 7 684321 35 49920761
Bone density abnormal 11.15 10.85 75 684253 2970 49917826
Occupational asthma 11.15 10.85 11 684317 116 49920680
Hypersomnia 11.14 10.85 143 684185 15171 49905625
Therapy change 11.07 10.85 35 684293 5190 49915606
Microsporum infection 11.07 10.85 4 684324 3 49920793
Papillary renal cell carcinoma 11.07 10.85 4 684324 3 49920793
Hepatic cyst 11.07 10.85 28 684300 4465 49916331
Haemodialysis 11.01 10.85 67 684261 8295 49912501
Inadequate analgesia 10.99 10.85 11 684317 2547 49918249
Cytomegalovirus infection reactivation 10.99 10.85 67 684261 2564 49918232
Metastasis 10.98 10.85 27 684301 4348 49916448
Sputum culture positive 10.97 10.85 43 684285 1371 49919425
Drug effective for unapproved indication 10.96 10.85 55 684273 1954 49918842
Necrotising ulcerative gingivostomatitis 10.96 10.85 6 684322 22 49920774
Haemophilus infection 10.96 10.85 35 684293 1006 49919790
Oesophageal ulcer 10.95 10.85 91 684237 3854 49916942
Increased bronchial secretion 10.93 10.85 46 684282 1516 49919280
Endocarditis Q fever 10.92 10.85 5 684323 11 49920785
Graft versus host disease in liver 10.90 10.85 22 684306 472 49920324
Large intestinal ulcer 10.88 10.85 75 684253 2994 49917802
Thyroid neoplasm 10.88 10.85 83 684245 3424 49917372
Coronary artery bypass 10.88 10.85 9 684319 2284 49918512
Nicotine dependence 10.86 10.85 26 684302 629 49920167

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 663.45 11.42 1302 337722 32547 29202956
Drug abuse 636.89 11.42 82 338942 79801 29155702
Colitis ulcerative 617.43 11.42 747 338277 12022 29223481
Completed suicide 603.81 11.42 146 338878 90100 29145403
Drug ineffective 543.50 11.42 6447 332577 356723 28878780
Off label use 530.49 11.42 5517 333507 295283 28940220
Product use in unapproved indication 451.75 11.42 2083 336941 84792 29150711
Nocardiosis 424.13 11.42 329 338695 2931 29232572
Wheezing 420.67 11.42 1074 337950 32166 29203337
Rheumatoid arthritis 417.47 11.42 1049 337975 31103 29204400
Transplant rejection 372.46 11.42 493 338531 8719 29226784
Therapeutic product effect incomplete 359.32 11.42 1129 337895 38176 29197327
Post transplant lymphoproliferative disorder 343.03 11.42 367 338657 5126 29230377
Overdose 338.69 11.42 252 338772 79567 29155936
Polyomavirus-associated nephropathy 329.37 11.42 289 338735 3107 29232396
Sleep disorder due to a general medical condition 325.92 11.42 278 338746 2868 29232635
Toxicity to various agents 309.25 11.42 992 338032 172669 29062834
Intentional overdose 305.83 11.42 40 338984 38488 29197015
Kidney transplant rejection 298.91 11.42 385 338639 6620 29228883
Aspergillus infection 297.64 11.42 477 338547 10104 29225399
Obstructive airways disorder 286.06 11.42 479 338545 10537 29224966
Condition aggravated 284.36 11.42 2741 336283 143554 29091949
Death 269.91 11.42 2566 336458 339518 28895985
Cytomegalovirus infection 265.04 11.42 722 338302 22493 29213010
Intentional product use issue 244.74 11.42 1051 337973 41447 29194056
Bradycardia 243.12 11.42 236 338788 65393 29170110
Full blood count abnormal 236.19 11.42 528 338496 14485 29221018
Loss of personal independence in daily activities 228.98 11.42 727 338297 24713 29210790
Strongyloidiasis 224.72 11.42 197 338827 2115 29233388
Pneumocystis jirovecii pneumonia 214.10 11.42 544 338480 16235 29219268
Fall 209.17 11.42 1184 337840 175994 29059509
Somnolence 204.82 11.42 486 338538 93469 29142034
Productive cough 196.34 11.42 794 338230 30465 29205038
Phaeohyphomycosis 192.64 11.42 118 338906 682 29234821
Cryptococcosis 191.07 11.42 167 338857 1785 29233718
Mucormycosis 190.20 11.42 264 338760 4894 29230609
Blood pressure fluctuation 186.84 11.42 577 338447 19317 29216186
Hypotension 178.52 11.42 1400 337624 192954 29042549
Frequent bowel movements 177.97 11.42 353 338671 8886 29226617
Electrocardiogram QT prolonged 175.13 11.42 98 338926 36039 29199464
Rhabdomyolysis 174.12 11.42 267 338757 60541 29174962
Loss of consciousness 170.34 11.42 372 338652 73684 29161819
Bronchiectasis 169.18 11.42 285 338739 6300 29229203
Disease recurrence 167.89 11.42 481 338543 15433 29220070
Hypoglycaemia 165.34 11.42 186 338838 48160 29187343
Dizziness 163.37 11.42 1390 337634 188294 29047209
Confusional state 163.26 11.42 832 338192 127045 29108458
Suicide attempt 161.73 11.42 95 338929 34015 29201488
Seizure 160.59 11.42 539 338485 92584 29142919
Histoplasmosis 157.43 11.42 128 338896 1228 29234275
Myocardial infarction 153.35 11.42 696 338328 109600 29125903
Transplant dysfunction 151.23 11.42 157 338867 2113 29233390
Cytomegalovirus viraemia 149.87 11.42 264 338760 6056 29229447
Diffuse large B-cell lymphoma recurrent 149.06 11.42 166 338858 2431 29233072
Blood creatine phosphokinase increased 148.34 11.42 148 338876 40496 29195007
Arthralgia 148.23 11.42 2335 336689 137282 29098221
Agitation 148.09 11.42 224 338800 51080 29184423
Aggression 147.08 11.42 115 338909 35426 29200077
Histoplasmosis disseminated 143.50 11.42 113 338911 1031 29234472
Epstein-Barr virus infection 138.33 11.42 262 338762 6367 29229136
Joint swelling 136.04 11.42 1005 338019 48625 29186878
Progressive multifocal leukoencephalopathy 135.28 11.42 305 338719 8414 29227089
Sputum discoloured 134 11.42 257 338767 6306 29229197
Cardio-respiratory arrest 132.00 11.42 236 338788 50365 29185138
Depressed level of consciousness 131.99 11.42 137 338887 36805 29198698
Complications of transplanted kidney 131.98 11.42 193 338831 3761 29231742
Coma 130.32 11.42 156 338868 39294 29196209
Drug level below therapeutic 126.26 11.42 197 338827 4074 29231429
BK virus infection 125.31 11.42 207 338817 4500 29231003
Bronchopulmonary aspergillosis 125.30 11.42 368 338656 11976 29223527
Intentional product misuse 124.45 11.42 128 338896 34533 29200970
Cough 119.88 11.42 2080 336944 124647 29110856
Hepatic function abnormal 119.60 11.42 165 338859 39094 29196409
Hallucination 118.92 11.42 206 338818 44506 29190997
Treatment failure 118.89 11.42 778 338246 36161 29199342
Human herpesvirus 8 infection 117.90 11.42 89 338935 758 29234745
Syncope 116.95 11.42 507 338517 80864 29154639
Neuroleptic malignant syndrome 116.29 11.42 22 339002 16126 29219377
COVID-19 116.20 11.42 759 338265 35255 29200248
Acute kidney injury 114.98 11.42 2247 336777 263020 28972483
Sedation 112.72 11.42 30 338994 17375 29218128
Forced expiratory volume decreased 111.32 11.42 149 338875 2664 29232839
West Nile viral infection 110.29 11.42 77 338947 573 29234930
Chronic allograft nephropathy 109.99 11.42 96 338928 1024 29234479
Rebound effect 108.38 11.42 125 338899 1906 29233597
Serotonin syndrome 108.21 11.42 33 338991 17479 29218024
Osteoporosis 107.35 11.42 319 338705 10450 29225053
Hepatitis B reactivation 106.89 11.42 157 338867 3072 29232431
Nasal congestion 106.39 11.42 464 338560 18415 29217088
Angioedema 105.63 11.42 126 338898 31789 29203714
Therapy partial responder 104.20 11.42 202 338822 4997 29230506
Constipation 103.37 11.42 825 338199 113335 29122168
Respiratory depression 102.71 11.42 16 339008 13507 29221996
Nausea 102.42 11.42 2530 336494 286725 28948778
Restlessness 101.73 11.42 64 338960 22081 29213422
Suicidal ideation 100.72 11.42 151 338873 34565 29200938
Varicella zoster virus infection 100.44 11.42 103 338921 1365 29234138
Cytomegalovirus colitis 99.58 11.42 132 338892 2337 29233166
Focal segmental glomerulosclerosis 99.44 11.42 113 338911 1694 29233809
General physical health deterioration 98.91 11.42 731 338293 102126 29133377
Mycobacterial infection 96.98 11.42 113 338911 1743 29233760
Steroid dependence 95.74 11.42 53 338971 245 29235258
Rash 95.72 11.42 1565 337459 188254 29047249
Drug interaction 95.10 11.42 1641 337383 195744 29039759
Delirium 93.79 11.42 194 338830 39203 29196300
Hyponatraemia 93.19 11.42 428 338596 67205 29168298
International normalised ratio increased 92.30 11.42 235 338789 44137 29191366
Cerebral infarction 92.17 11.42 88 338936 24587 29210916
Renal transplant failure 92.02 11.42 82 338942 901 29234602
Therapeutic product effect decreased 91.56 11.42 615 338409 28836 29206667
Product use issue 91.46 11.42 947 338077 50497 29185006
Blastomycosis 90.78 11.42 52 338972 260 29235243
Abnormal behaviour 90.52 11.42 79 338945 23048 29212455
Brain abscess 89.20 11.42 130 338894 2525 29232978
Extrapyramidal disorder 88.99 11.42 10 339014 10821 29224682
JC virus infection 88.46 11.42 109 338915 1788 29233715
Cardiac arrest 87.78 11.42 597 338427 84994 29150509
Vomiting 87.64 11.42 1812 337212 210448 29025055
Immunosuppressant drug level increased 86.92 11.42 178 338846 4587 29230916
Mycobacterium avium complex infection 86.46 11.42 118 338906 2151 29233352
Pseudomonas infection 85.90 11.42 297 338727 10555 29224948
Pulmonary mass 85.82 11.42 295 338729 10453 29225050
Intentional self-injury 85.54 11.42 19 339005 12442 29223061
Respiratory arrest 83.36 11.42 104 338920 25729 29209774
Fungal infection 83.03 11.42 344 338680 13341 29222162
Posterior reversible encephalopathy syndrome 83.02 11.42 259 338765 8717 29226786
Faecal calprotectin increased 81.50 11.42 95 338929 1466 29234037
Clostridium difficile infection 80 11.42 382 338642 15759 29219744
Graft loss 79.90 11.42 71 338953 777 29234726
Meningitis cryptococcal 79.70 11.42 109 338915 1991 29233512
Parvovirus B19 infection 79.15 11.42 66 338958 658 29234845
Cardiac failure 78.85 11.42 558 338466 78729 29156774
Sensitivity to weather change 78.53 11.42 89 338935 1330 29234173
Lymphadenopathy 77.81 11.42 523 338501 24526 29210977
Kidney fibrosis 77.31 11.42 106 338918 1941 29233562
Septic shock 77.09 11.42 1074 337950 61486 29174017
Colitis 76.80 11.42 617 338407 30631 29204872
Sinus pain 76.75 11.42 60 338964 541 29234962
Haematotoxicity 76.07 11.42 208 338816 6491 29229012
Pneumonia aspiration 75.30 11.42 196 338828 36541 29198962
Cerebrovascular accident 75.15 11.42 544 338480 76367 29159136
Nasal polyps 75.11 11.42 97 338927 1672 29233831
Lung transplant rejection 75.04 11.42 64 338960 660 29234843
Cryptosporidiosis infection 74.52 11.42 51 338973 366 29235137
Rhodococcus infection 74.28 11.42 37 338987 131 29235372
Prostatic specific antigen increased 74.02 11.42 313 338711 12251 29223252
Adenovirus infection 74.00 11.42 160 338864 4287 29231216
Osteonecrosis 73.69 11.42 329 338695 13190 29222313
Asthma-chronic obstructive pulmonary disease overlap syndrome 73.60 11.42 64 338960 679 29234824
Febrile neutropenia 73.07 11.42 1743 337281 110497 29125006
Lactic acidosis 72.79 11.42 148 338876 30099 29205404
Infection reactivation 72.09 11.42 75 338949 1012 29234491
Epistaxis 71.93 11.42 326 338698 51378 29184125
Altered state of consciousness 71.89 11.42 73 338951 19816 29215687
Arthropathy 71.80 11.42 458 338566 21096 29214407
Pneumonia cytomegaloviral 71.46 11.42 118 338906 2564 29232939
Coronary artery disease 71.26 11.42 263 338761 43927 29191576
Liver disorder 70.05 11.42 132 338892 27617 29207886
Legionella infection 69.91 11.42 51 338973 410 29235093
Dyskinesia 69.85 11.42 76 338948 19985 29215518
Pulmonary function test decreased 69.52 11.42 150 338874 4013 29231490
Renal tubular atrophy 69.35 11.42 72 338952 969 29234534
Inappropriate schedule of product administration 68.16 11.42 795 338229 43677 29191826
Disorientation 68.02 11.42 148 338876 29367 29206136
Musculoskeletal stiffness 67.73 11.42 692 338332 36766 29198737
Acute myocardial infarction 67.62 11.42 305 338719 48133 29187370
Fungal skin infection 67.28 11.42 108 338916 2290 29233213
Dysarthria 67.19 11.42 160 338864 30751 29204752
Circulatory collapse 66.97 11.42 69 338955 18604 29216899
Hepatitis B 66.78 11.42 175 338849 5322 29230181
Herpes zoster 66.73 11.42 580 338444 29472 29206031
Eosinophil count abnormal 66.52 11.42 41 338983 240 29235263
White blood cell count decreased 66.25 11.42 623 338401 82739 29152764
Aspartate aminotransferase increased 65.57 11.42 408 338616 59317 29176186
Erectile dysfunction 65.21 11.42 66 338958 17943 29217560
Weight decreased 64.78 11.42 2223 336801 148682 29086821
Cardiac failure congestive 64.48 11.42 564 338460 76017 29159486
Weight increased 64.19 11.42 1235 337789 75432 29160071
Graft versus host disease in lung 63.95 11.42 50 338974 451 29235052
Cushingoid 63.27 11.42 106 338918 2332 29233171
Alternaria infection 63.24 11.42 42 338982 285 29235218
Therapeutic response shortened 62.84 11.42 157 338867 4634 29230869
Miosis 61.92 11.42 9 339015 8000 29227503
Cerebral aspergillosis 61.76 11.42 77 338947 1279 29234224
Arthritis 61.47 11.42 494 338530 24525 29210978
Infection 61.44 11.42 1228 337796 75523 29159980
Wrong technique in product usage process 61.15 11.42 172 338852 31256 29204247
Scedosporium infection 60.95 11.42 59 338965 726 29234777
Palmar-plantar erythrodysaesthesia syndrome 60.74 11.42 48 338976 14711 29220792
Drug level decreased 60.33 11.42 183 338841 6064 29229439
American trypanosomiasis 59.97 11.42 37 338987 217 29235286
Orthostatic hypotension 59.48 11.42 105 338919 22524 29212979
Disturbance in attention 59.45 11.42 96 338928 21328 29214175
Drug withdrawal syndrome 58.44 11.42 72 338952 17912 29217591
Steroid diabetes 58.18 11.42 84 338940 1617 29233886
Irritability 58.03 11.42 103 338921 22049 29213454
Tachycardia 58.02 11.42 540 338484 71870 29163633
Philadelphia positive chronic myeloid leukaemia 57.85 11.42 26 338998 68 29235435
Hepatitis E 57.75 11.42 83 338941 1591 29233912
Cognitive disorder 57.38 11.42 114 338910 23385 29212118
Crohn's disease 56.78 11.42 114 338910 2895 29232608
Schizophrenia 56.71 11.42 5 339019 6560 29228943
Impaired quality of life 56.49 11.42 105 338919 2514 29232989
Hyperkalaemia 56.28 11.42 442 338582 60950 29174553
Dehydration 56.11 11.42 951 338073 113797 29121706
Cerebral haemorrhage 56.10 11.42 179 338845 31247 29204256
Bacillary angiomatosis 56.07 11.42 27 338997 87 29235416
Labelled drug-drug interaction medication error 56.03 11.42 35 338989 12124 29223379
Stevens-Johnson syndrome 55.79 11.42 64 338960 16433 29219070
Decreased appetite 55.75 11.42 1255 337769 144087 29091416
Osteopenia 55.11 11.42 137 338887 4031 29231472
Heart transplant rejection 55.07 11.42 67 338957 1084 29234419
Accidental overdose 54.52 11.42 73 338951 17520 29217983
Pulmonary nocardiosis 54.48 11.42 48 338976 519 29234984
Encephalitis viral 54.33 11.42 66 338958 1066 29234437
Unresponsive to stimuli 53.86 11.42 131 338893 24995 29210508
Lymphopenia 53.68 11.42 301 338723 13232 29222271
Candida infection 52.88 11.42 327 338697 14898 29220605
Platelet count decreased 52.64 11.42 863 338161 103809 29131694
Depression 52.62 11.42 674 338350 84473 29151030
Memory impairment 52.50 11.42 227 338797 36243 29199260
Therapeutic reaction time decreased 52.28 11.42 51 338973 634 29234869
Bronchial wall thickening 51.58 11.42 62 338962 990 29234513
Nasal obstruction 51.51 11.42 46 338978 507 29234996
Malacoplakia 51.19 11.42 27 338997 111 29235392
Immunosuppression 51.19 11.42 155 338869 5131 29230372
Trichodysplasia spinulosa 50.63 11.42 33 338991 216 29235287
COVID-19 pneumonia 50.60 11.42 230 338794 9292 29226211
Paranoia 50.47 11.42 25 338999 9852 29225651
Product prescribing error 50.40 11.42 80 338944 17896 29217607
Alanine aminotransferase increased 50.22 11.42 545 338479 70399 29165104
Epidermodysplasia verruciformis 50.21 11.42 26 338998 102 29235401
Bronchopulmonary aspergillosis allergic 50.06 11.42 44 338980 474 29235029
Poisoning 50.01 11.42 26 338998 9967 29225536
Escherichia infection 49.99 11.42 181 338843 6583 29228920
Haematemesis 49.99 11.42 132 338892 24494 29211009
Blood immunoglobulin E increased 49.66 11.42 84 338940 1863 29233640
Gamma-glutamyltransferase increased 49.35 11.42 150 338874 26587 29208916
Muscle rigidity 49.35 11.42 23 339001 9388 29226115
Heart rate decreased 49.29 11.42 469 338555 24443 29211060
Drug reaction with eosinophilia and systemic symptoms 48.88 11.42 161 338863 27831 29207672
Herpes simplex 48.87 11.42 145 338879 4745 29230758
Blood bilirubin increased 48.76 11.42 211 338813 33682 29201821
Impaired work ability 48.75 11.42 159 338865 5481 29230022
Epstein-Barr viraemia 48.54 11.42 58 338966 920 29234583
Medial tibial stress syndrome 48.52 11.42 18 339006 22 29235481
Respiratory failure 48.44 11.42 1457 337567 95674 29139829
Nightmare 48.42 11.42 36 338988 11381 29224122
Diffuse large B-cell lymphoma 48.14 11.42 170 338854 6106 29229397
Drug eruption 47.41 11.42 74 338950 16667 29218836
Melaena 47.39 11.42 190 338834 30986 29204517
Joint stiffness 46.80 11.42 224 338800 9249 29226254
Bronchial obstruction 46.57 11.42 68 338956 1323 29234180
Subdural haematoma 46.39 11.42 86 338938 18107 29217396
Gastroenteritis norovirus 46.39 11.42 68 338956 1328 29234175
Balance disorder 46.25 11.42 235 338789 35935 29199568
Dust allergy 46.19 11.42 41 338983 448 29235055
Mucous stools 46.18 11.42 61 338963 1076 29234427
Diarrhoea 46.01 11.42 3240 335784 329458 28906045
Second primary malignancy 45.86 11.42 175 338849 6530 29228973
Defaecation urgency 45.33 11.42 76 338948 1673 29233830
Sinusitis 45.27 11.42 597 338427 33753 29201750
Myocardial ischaemia 45.25 11.42 71 338953 15957 29219546
Liver transplant rejection 44.93 11.42 81 338943 1893 29233610
Disseminated cryptococcosis 44.49 11.42 61 338963 1117 29234386
Pulmonary oedema 43.81 11.42 298 338726 42437 29193066
Lung opacity 43.67 11.42 66 338958 1326 29234177
Skin lesion 43.62 11.42 363 338661 18209 29217294
Diabetes mellitus 43.59 11.42 670 338354 39161 29196342
Tremor 43.27 11.42 588 338436 72950 29162553
Urinary retention 43.23 11.42 203 338821 31695 29203808
Diffuse large B-cell lymphoma refractory 43.03 11.42 53 338971 869 29234634
Foot deformity 42.96 11.42 122 338902 3893 29231610
Night sweats 42.96 11.42 306 338718 14626 29220877
Infusion related reaction 42.72 11.42 724 338300 43162 29192341
Anaphylactic shock 42.70 11.42 54 338970 13282 29222221
Inflammation 42.57 11.42 423 338601 22305 29213198
Myoclonus 42.50 11.42 54 338970 13255 29222248
Eosinophilic granulomatosis with polyangiitis 42.46 11.42 65 338959 1321 29234182
Coccidioidomycosis 42.39 11.42 44 338980 592 29234911
Skin mass 42.22 11.42 110 338914 3333 29232170
Psychotic disorder 42.16 11.42 108 338916 20246 29215257
Diabetic ketoacidosis 41.86 11.42 75 338949 15998 29219505
Pulmonary function test abnormal 41.85 11.42 81 338943 2001 29233502
Dermatophytosis 41.58 11.42 28 338996 195 29235308
Human ehrlichiosis 41.51 11.42 27 338997 176 29235327
Sinus bradycardia 41.47 11.42 43 338981 11560 29223943
B-cell lymphoma recurrent 41.34 11.42 43 338981 580 29234923
Hyperhidrosis 41.32 11.42 507 338517 64033 29171470
Obstruction 41.27 11.42 77 338947 1849 29233654
Delayed graft function 41.24 11.42 77 338947 1850 29233653
Enterococcal infection 41.20 11.42 196 338828 8072 29227431
Rheumatoid factor positive 41.14 11.42 44 338980 614 29234889
Toxic epidermal necrolysis 41.02 11.42 92 338932 18061 29217442
Muscle spasms 41.01 11.42 513 338511 64569 29170934
Heart rate irregular 40.81 11.42 274 338750 12843 29222660
Neutrophil count decreased 40.70 11.42 312 338712 43255 29192248
Graft versus host disease in skin 40.46 11.42 107 338917 3272 29232231
Body temperature fluctuation 40.26 11.42 65 338959 1385 29234118
Dystonia 39.75 11.42 32 338992 9717 29225786
Foetal exposure during pregnancy 39.45 11.42 227 338797 33640 29201863
Klebsiella infection 39.41 11.42 178 338846 7171 29228332
Therapeutic response decreased 38.85 11.42 444 338580 24267 29211236
Product substitution issue 38.80 11.42 29 338995 9143 29226360
Disseminated varicella zoster virus infection 38.74 11.42 24 339000 142 29235361
Mass 38.71 11.42 173 338851 6938 29228565
Renal graft infection 38.69 11.42 28 338996 222 29235281
Chronic sinusitis 38.68 11.42 70 338954 1641 29233862
Hypofibrinogenaemia 38.60 11.42 65 338959 1436 29234067
Mydriasis 38.44 11.42 11 339013 6074 29229429
Necrotising oesophagitis 38.23 11.42 38 338986 484 29235019
Tardive dyskinesia 38.21 11.42 7 339017 5251 29230252
Pneumonia fungal 38.06 11.42 149 338875 5628 29229875
Gastrointestinal haemorrhage 37.93 11.42 662 338362 78871 29156632
Epstein-Barr virus associated lymphoproliferative disorder 37.89 11.42 70 338954 1668 29233835
Graft versus host disease in gastrointestinal tract 37.83 11.42 102 338922 3156 29232347
Parkinsonism 37.83 11.42 18 339006 7260 29228243
Pneumocystis jirovecii infection 37.63 11.42 63 338961 1385 29234118
Blood pressure increased 37.57 11.42 1110 337914 72693 29162810
Status epilepticus 37.46 11.42 41 338983 10753 29224750
Acanthamoeba infection 37.42 11.42 34 338990 384 29235119
Nephropathy toxic 37.34 11.42 231 338793 10525 29224978
Acute myeloid leukaemia 37.33 11.42 320 338704 16193 29219310
Osteomyelitis fungal 37.31 11.42 27 338997 214 29235289
Hallucination, auditory 37.26 11.42 33 338991 9560 29225943
Nasopharyngitis 37.10 11.42 921 338103 58744 29176759
Lung hyperinflation 36.81 11.42 46 338978 766 29234737
Ventricular fibrillation 36.80 11.42 79 338945 15754 29219749
Visceral leishmaniasis 36.75 11.42 37 338987 479 29235024
Enterovirus infection 36.68 11.42 42 338982 635 29234868
Blood pressure diastolic increased 36.55 11.42 109 338915 3577 29231926
Akathisia 36.09 11.42 16 339008 6726 29228777
Endophthalmitis 35.97 11.42 92 338932 2756 29232747
Prostate cancer metastatic 35.95 11.42 132 338892 4834 29230669
Scleroderma 35.83 11.42 59 338965 1279 29234224
Epilepsy 35.76 11.42 101 338923 18331 29217172
Squamous cell carcinoma of skin 35.66 11.42 208 338816 9278 29226225
Vital capacity decreased 35.64 11.42 31 338993 329 29235174
Choroiditis 35.58 11.42 50 338974 938 29234565
End stage renal disease 35.55 11.42 178 338846 7486 29228017
Disease progression 35.40 11.42 1208 337816 80708 29154795
Myelodysplastic syndrome 35.20 11.42 335 338689 17459 29218044
Pneumoperitoneum 35.11 11.42 64 338960 1509 29233994
Fistula 35.04 11.42 134 338890 5005 29230498
Amnesia 35.04 11.42 137 338887 22506 29212997
Uveitis 34.91 11.42 148 338876 5799 29229704
Poor venous access 34.75 11.42 97 338927 3064 29232439
Product quality issue 34.75 11.42 82 338942 15813 29219690
Pericarditis fungal 34.49 11.42 22 339002 138 29235365
Spirometry abnormal 34.40 11.42 31 338993 346 29235157
Cryptococcal cutaneous infection 34.38 11.42 17 339007 59 29235444
Delusion 34.29 11.42 47 338977 11169 29224334
Influenza 34.13 11.42 672 338352 41209 29194294
Granulocytopenia 34.07 11.42 13 339011 5981 29229522
Respiratory disorder 33.73 11.42 320 338704 16663 29218840
Withdrawal syndrome 33.66 11.42 46 338978 10946 29224557
Speech disorder 33.45 11.42 147 338877 23369 29212134
Mycobacterium chelonae infection 33.42 11.42 38 338986 570 29234933
Acute respiratory distress syndrome 33.36 11.42 406 338618 22529 29212974
Body temperature decreased 33.32 11.42 223 338801 10441 29225062
Abnormal dreams 33.18 11.42 19 339005 6901 29228602
Cytomegalovirus gastrointestinal infection 33.07 11.42 23 339001 170 29235333
Medication error 33.04 11.42 128 338896 21083 29214420
Hypomagnesaemia 32.95 11.42 97 338927 17371 29218132
Sporotrichosis 32.91 11.42 15 339009 41 29235462
Product dose omission issue 32.59 11.42 848 338176 95535 29139968
Pneumonia pseudomonal 32.41 11.42 97 338927 3190 29232313
Cat scratch disease 32.38 11.42 18 339006 84 29235419
Stenotrophomonas infection 32.34 11.42 65 338959 1652 29233851
Suspected suicide 32.31 11.42 4 339020 4016 29231487
Colectomy 32.10 11.42 60 338964 1443 29234060
Bradyphrenia 31.97 11.42 5 339019 4209 29231294
Steroid withdrawal syndrome 31.92 11.42 24 339000 203 29235300
Solar lentigo 31.74 11.42 31 338993 386 29235117
Lung consolidation 31.56 11.42 128 338896 4915 29230588
Mobility decreased 31.49 11.42 442 338582 25338 29210165
Abdominal abscess 31.44 11.42 106 338918 3718 29231785
Periostitis 31.41 11.42 25 338999 232 29235271
Obsessive-compulsive disorder 31.36 11.42 7 339017 4569 29230934
Mycobacterium abscessus infection 31.33 11.42 32 338992 422 29235081
Arrhythmia 31.28 11.42 220 338804 31093 29204410
Lymphoproliferative disorder 31.26 11.42 81 338943 2446 29233057
Tendon rupture 31.20 11.42 149 338875 6146 29229357
Dysplastic naevus 30.99 11.42 31 338993 398 29235105
Myalgia 30.99 11.42 630 338394 73389 29162114
Myopathy 30.97 11.42 217 338807 10316 29225187
Disseminated tuberculosis 30.84 11.42 69 338955 1893 29233610
Cerebral toxoplasmosis 30.83 11.42 57 338967 1359 29234144
Gastrointestinal inflammation 30.83 11.42 90 338934 2918 29232585
Babesiosis 30.78 11.42 15 339009 50 29235453
Cerebral fungal infection 30.74 11.42 24 339000 216 29235287
Pruritus 30.61 11.42 1064 337960 115785 29119718
Mantle cell lymphoma recurrent 30.61 11.42 33 338991 465 29235038
Salivary hypersecretion 30.61 11.42 24 339000 7385 29228118
Disseminated blastomycosis 30.47 11.42 17 339007 80 29235423
Product administration error 30.36 11.42 75 338949 14235 29221268
Shock 30.32 11.42 134 338890 21270 29214233
Oropharyngeal pain 30.29 11.42 488 338536 28797 29206706
Psoriatic arthropathy 30.27 11.42 279 338745 14412 29221091
Small for dates baby 30.18 11.42 3 339021 3576 29231927
Blood alkaline phosphatase increased 30.16 11.42 196 338828 28210 29207293
Haemophagocytic lymphohistiocytosis 30.07 11.42 215 338809 10289 29225214
Anxiety 29.94 11.42 747 338277 84618 29150885
Breath sounds abnormal 29.88 11.42 133 338891 5324 29230179
Meningitis listeria 29.76 11.42 29 338995 360 29235143
Coronavirus infection 29.60 11.42 94 338930 3194 29232309
Vascular hyalinosis 29.52 11.42 12 339012 22 29235481
Human polyomavirus infection 29.51 11.42 38 338986 653 29234850
Insomnia 29.46 11.42 783 338241 87978 29147525
Squamous cell carcinoma 29.44 11.42 210 338814 10041 29225462
Necrotising retinitis 29.35 11.42 40 338984 728 29234775
Hallucination, visual 29.33 11.42 82 338942 14933 29220570
Upper respiratory fungal infection 29.32 11.42 19 339005 123 29235380
Sexual dysfunction 29.28 11.42 15 339009 5799 29229704
Exposure during pregnancy 29.13 11.42 33 338991 8521 29226982
Sudden death 29.12 11.42 75 338949 14035 29221468
Cytology abnormal 29.08 11.42 29 338995 371 29235132
Upper-airway cough syndrome 29.02 11.42 88 338936 2915 29232588
Coma scale abnormal 29.02 11.42 3 339021 3466 29232037
Primary effusion lymphoma 28.99 11.42 11 339013 15 29235488
Blood cholesterol 28.97 11.42 21 339003 167 29235336
Fear 28.88 11.42 40 338984 9464 29226039
Poisoning deliberate 28.55 11.42 15 339009 5716 29229787
Tuberculosis 28.50 11.42 160 338864 7036 29228467
Herpes zoster cutaneous disseminated 28.41 11.42 20 339004 151 29235352
Haematochezia 28.33 11.42 588 338436 36395 29199108
Right atrial hypertrophy 28.32 11.42 33 338991 509 29234994
Central nervous system infection 28.32 11.42 33 338991 509 29234994
Euphoric mood 28.21 11.42 10 339014 4815 29230688
Cutaneous blastomycosis 28.20 11.42 11 339013 17 29235486
Smooth muscle cell neoplasm 28.14 11.42 19 339005 133 29235370
Ventricular tachycardia 28.10 11.42 148 338876 22426 29213077
Leukopenia 28.01 11.42 830 338194 54373 29181130
Palpitations 27.92 11.42 239 338785 32365 29203138
Listeria encephalitis 27.91 11.42 13 339011 38 29235465
Unevaluable event 27.77 11.42 214 338810 29637 29205866
Restrictive pulmonary disease 27.57 11.42 47 338977 1049 29234454
Bladder cancer 27.51 11.42 46 338978 10081 29225422
Photodermatosis 27.49 11.42 30 338994 429 29235074
Cystitis haemorrhagic 27.27 11.42 119 338905 4723 29230780
Corynebacterium infection 27.21 11.42 29 338995 403 29235100
Hiccups 27.16 11.42 37 338987 8816 29226687
Tuberculosis of central nervous system 27.12 11.42 18 339006 122 29235381
Ventricular extrasystoles 27.00 11.42 50 338974 10532 29224971
Allergy to animal 26.98 11.42 23 339001 237 29235266
Transplant failure 26.96 11.42 83 338941 2773 29232730
Staphylococcal infection 26.87 11.42 478 338546 28762 29206741
Ascites 26.83 11.42 279 338745 36340 29199163
Arthritis bacterial 26.82 11.42 111 338913 4302 29231201
Ataxia 26.81 11.42 62 338962 12041 29223462
Sopor 26.73 11.42 53 338971 10881 29224622
Mycobacterium marinum infection 26.70 11.42 24 339000 267 29235236
Pemphigus 26.68 11.42 48 338976 1120 29234383
Cataract 26.66 11.42 382 338642 21996 29213507
Blood pressure decreased 26.60 11.42 364 338660 45113 29190390
Hypogammaglobulinaemia 26.56 11.42 136 338888 5771 29229732
Complications of transplanted lung 26.53 11.42 20 339004 170 29235333
Meningitis enterococcal 26.50 11.42 15 339009 73 29235430
Depressed mood 26.43 11.42 98 338926 16350 29219153
Head injury 26.38 11.42 95 338929 15986 29219517
Cyanosis 26.37 11.42 56 338968 11211 29224292
Tendon disorder 26.23 11.42 75 338949 2403 29233100
Muscle twitching 26.22 11.42 32 338992 7994 29227509
Pneumonia cryptococcal 26.07 11.42 38 338986 738 29234765
Ventricular remodelling 26.03 11.42 15 339009 76 29235427
Trichophytosis 25.93 11.42 23 339001 251 29235252
Dysphagia 25.91 11.42 458 338566 54468 29181035
Vaccination failure 25.79 11.42 31 338993 495 29235008
Chronic graft versus host disease in skin 25.79 11.42 39 338985 784 29234719
Skin squamous cell carcinoma recurrent 25.78 11.42 12 339012 35 29235468
Synovial cyst 25.76 11.42 63 338961 1834 29233669
Drug screen positive 25.68 11.42 6 339018 3795 29231708
Chest pain 25.67 11.42 1036 337988 110937 29124566
Herpes oesophagitis 25.65 11.42 16 339008 96 29235407
Bronchial disorder 25.61 11.42 47 338977 1114 29234389
Renal failure 25.57 11.42 1105 337919 117494 29118009
Muscle spasticity 25.50 11.42 12 339012 4871 29230632
Malignant transformation 25.39 11.42 39 338985 795 29234708
Dysgeusia 25.33 11.42 154 338870 22520 29212983
Hypokalaemia 25.18 11.42 414 338610 49789 29185714
Cytomegalovirus chorioretinitis 25.09 11.42 88 338936 3150 29232353
Lipodystrophy acquired 25.06 11.42 3 339021 3091 29232412
Blood sodium decreased 25.05 11.42 86 338938 14681 29220822
Post transplant distal limb syndrome 24.95 11.42 23 339001 265 29235238
Complications of transplanted heart 24.81 11.42 22 339002 240 29235263
Chronic graft versus host disease oral 24.73 11.42 13 339011 53 29235450
Kaposi's sarcoma 24.43 11.42 39 338985 823 29234680
Mental impairment 24.39 11.42 42 338982 9099 29226404
Diabetic cardiomyopathy 24.37 11.42 10 339014 19 29235484
Peripheral swelling 24.35 11.42 927 338097 62812 29172691
Granulomatosis with polyangiitis 24.33 11.42 40 338984 866 29234637
Disseminated aspergillosis 24.32 11.42 27 338997 394 29235109
Acne 24.27 11.42 185 338839 9035 29226468
Chronic obstructive pulmonary disease 24.21 11.42 628 338396 40327 29195176
Injury 24.19 11.42 124 338900 18922 29216581
Acquired apparent mineralocorticoid excess 24.15 11.42 11 339013 30 29235473
Abscess 24.11 11.42 193 338831 9569 29225934
Coombs positive haemolytic anaemia 24.08 11.42 36 338988 716 29234787
Lung disorder 24.00 11.42 485 338539 29877 29205626
Stomatitis 23.95 11.42 291 338733 36822 29198681
Lymphadenitis 23.58 11.42 55 338969 1552 29233951
Bacterial pyelonephritis 23.55 11.42 21 339003 231 29235272
Asphyxia 23.54 11.42 16 339008 5299 29230204
Prescribed underdose 23.42 11.42 33 338991 7753 29227750
Epstein-Barr virus associated lymphoma 23.38 11.42 31 338993 549 29234954
Multiple sclerosis relapse 23.33 11.42 61 338963 11358 29224145
Presyncope 23.23 11.42 100 338924 15989 29219514
Disseminated Bacillus Calmette-Guerin infection 23.23 11.42 18 339006 160 29235343
Obliterative bronchiolitis 23.15 11.42 44 338980 1072 29234431
Cutaneous sporotrichosis 23.13 11.42 10 339014 23 29235480
Cryptococcal fungaemia 23.12 11.42 14 339010 79 29235424
Electrocardiogram abnormal 23.07 11.42 30 338994 7292 29228211
Mycobacterium fortuitum infection 22.96 11.42 18 339006 163 29235340
Diverticulitis intestinal perforated 22.84 11.42 10 339014 24 29235479
Diaphragmatic hernia 22.78 11.42 21 339003 242 29235261
Hyperglycaemia 22.73 11.42 534 338490 33753 29201750
Bronchial hyperreactivity 22.73 11.42 50 338974 1356 29234147
Mycotic allergy 22.71 11.42 21 339003 243 29235260
Joint lock 22.70 11.42 44 338980 1088 29234415
Inflammatory bowel disease 22.60 11.42 68 338956 2243 29233260
Hepatosplenic T-cell lymphoma 22.56 11.42 26 338998 396 29235107
Superinfection bacterial 22.53 11.42 34 338990 682 29234821
Chorioretinopathy 22.49 11.42 50 338974 1366 29234137
Haematuria 22.46 11.42 363 338661 43776 29191727
Wrong product administered 22.36 11.42 12 339012 4519 29230984
Acquired haemophilia 22.34 11.42 37 338987 806 29234697
Emphysematous pyelonephritis 22.28 11.42 11 339013 38 29235465
Intestinal perforation 22.28 11.42 164 338860 7922 29227581
Atrial septal defect 22.25 11.42 27 338997 6762 29228741
Angina pectoris 22.16 11.42 208 338816 27642 29207861
Nasal oedema 22.15 11.42 22 339002 280 29235223
Bronchial secretion retention 22.14 11.42 44 338980 1109 29234394
Spinal instability 22.11 11.42 24 339000 341 29235162
Acinetobacter infection 22.08 11.42 41 338983 981 29234522
Mycobacterium haemophilum infection 22.03 11.42 10 339014 27 29235476
Priapism 21.98 11.42 12 339012 4476 29231027
Lupus nephritis 21.93 11.42 20 339004 227 29235276
Blood urea increased 21.92 11.42 211 338813 27901 29207602
Adrenal insufficiency 21.86 11.42 209 338815 10905 29224598
Nodule 21.82 11.42 116 338908 4996 29230507
Respiratory symptom 21.76 11.42 39 338985 907 29234596
Electrolyte imbalance 21.70 11.42 62 338962 11212 29224291
Cardiogenic shock 21.61 11.42 130 338894 19060 29216443
Blood test abnormal 21.57 11.42 126 338898 5623 29229880
Sarcoidosis 21.54 11.42 73 338951 2567 29232936
Cardiomegaly 21.54 11.42 83 338941 13693 29221810
Hypernatraemia 21.54 11.42 32 338992 7354 29228149
Obstructive nephropathy 21.52 11.42 10 339014 29 29235474
Atlantoaxial instability 21.45 11.42 23 339001 322 29235181
Lymph node calcification 21.41 11.42 16 339008 134 29235369
Pulmonary mucormycosis 21.40 11.42 29 338995 525 29234978
Vasculitis 21.39 11.42 160 338864 7768 29227735
Hepatic encephalopathy 21.38 11.42 77 338947 12958 29222545
Sinusitis bacterial 21.25 11.42 22 339002 295 29235208
Anaemia 21.22 11.42 1999 337025 198952 29036551
Hyperthermia 21.14 11.42 48 338976 9382 29226121
Aphasia 21.13 11.42 131 338893 19067 29216436
Apparent mineralocorticoid excess 21.05 11.42 10 339014 31 29235472
Impaired healing 21.04 11.42 243 338781 13315 29222188
Encephalitis 21.02 11.42 136 338888 6294 29229209
Bacterial sepsis 20.95 11.42 108 338916 4595 29230908
Diarrhoea haemorrhagic 20.92 11.42 127 338897 5747 29229756
Eosinophil count 20.82 11.42 15 339009 118 29235385
Immunosuppressant drug level decreased 20.82 11.42 43 338981 1115 29234388
Gynaecomastia 20.81 11.42 39 338985 8178 29227325
Toxic skin eruption 20.80 11.42 51 338973 9706 29225797
Accidental exposure to product 20.80 11.42 59 338965 10694 29224809
Disability 20.79 11.42 103 338921 4313 29231190
Oral candidiasis 20.78 11.42 201 338823 10521 29224982
Physical disability 20.73 11.42 45 338979 1209 29234294
Tumour lysis syndrome 20.72 11.42 247 338777 13637 29221866
Hypertonia 20.63 11.42 9 339015 3820 29231683
Alcohol abuse 20.63 11.42 12 339012 4321 29231182
Toxoplasmosis 20.59 11.42 43 338981 1124 29234379
T-cell lymphoma 20.54 11.42 37 338987 864 29234639
Lung infiltration 20.51 11.42 216 338808 11563 29223940
Dislocation of vertebra 20.36 11.42 24 339000 375 29235128
Staphylococcal bacteraemia 20.32 11.42 145 338879 6934 29228569
Salmonellosis 20.31 11.42 33 338991 707 29234796
Emotional distress 20.29 11.42 86 338938 13809 29221694
Apnoea 20.28 11.42 24 339000 6078 29229425
Euglycaemic diabetic ketoacidosis 20.23 11.42 3 339021 2627 29232876
Pulmonary fibrosis 20.19 11.42 270 338754 15312 29220191
Syringe issue 20.17 11.42 9 339015 3769 29231734
Chondropathy 20.13 11.42 37 338987 878 29234625
Emphysema 20.10 11.42 169 338855 8502 29227001
Mineral metabolism disorder 20.02 11.42 23 339001 349 29235154
Drooling 19.96 11.42 5 339019 3016 29232487
Hypothermia 19.93 11.42 48 338976 9191 29226312
Psychomotor hyperactivity 19.91 11.42 40 338984 8173 29227330
Pleocytosis 19.84 11.42 26 338998 455 29235048
Pleural thickening 19.81 11.42 21 339003 290 29235213
Viral infection 19.76 11.42 258 338766 14552 29220951
Somnambulism 19.75 11.42 4 339020 2794 29232709
Reversible airways obstruction 19.74 11.42 19 339005 232 29235271
Infectious thyroiditis 19.72 11.42 13 339011 87 29235416
Knee arthroplasty 19.69 11.42 124 338900 5685 29229818
Blood triglycerides increased 19.63 11.42 78 338946 12756 29222747
Glycosylated haemoglobin increased 19.53 11.42 50 338974 9376 29226127
Upper gastrointestinal haemorrhage 19.50 11.42 159 338865 21755 29213748
Mite allergy 19.47 11.42 21 339003 296 29235207
Viraemia 19.45 11.42 40 338984 1034 29234469
Middle insomnia 19.44 11.42 122 338902 5586 29229917
Ammonia increased 19.42 11.42 11 339013 4020 29231483
Neutrophilic dermatosis 19.42 11.42 18 339006 209 29235294
Graft versus host disease 19.41 11.42 182 338842 9446 29226057
Blood potassium increased 19.40 11.42 94 338930 14557 29220946
Hypothyroidism 19.40 11.42 105 338919 15801 29219702
Orf 19.40 11.42 9 339015 26 29235477
Postoperative thoracic procedure complication 19.40 11.42 9 339015 26 29235477
Acute promyelocytic leukaemia 19.35 11.42 25 338999 431 29235072
Scleritis 19.31 11.42 21 339003 299 29235204
Sinus congestion 19.24 11.42 104 338920 4508 29230995
Escherichia sepsis 19.23 11.42 93 338931 3856 29231647
Pneumonia 19.22 11.42 4050 334974 316122 28919381
Antineutrophil cytoplasmic antibody positive 19.21 11.42 29 338995 582 29234921
Gastroenteritis cryptosporidial 19.15 11.42 16 339008 160 29235343
Wrist deformity 19.15 11.42 22 339002 334 29235169
Lethargy 19.14 11.42 309 338715 37271 29198232
Drug abuser 19.09 11.42 10 339014 3817 29231686
Granulomatous dermatitis 19.08 11.42 18 339006 214 29235289
Pancreatic carcinoma 18.95 11.42 33 338991 7117 29228386
Ketoacidosis 18.91 11.42 9 339015 3630 29231873
Lymphocele 18.91 11.42 45 338979 1287 29234216
Diverticular perforation 18.88 11.42 76 338948 2908 29232595
Listeriosis 18.80 11.42 36 338988 882 29234621
Rheumatoid lung 18.77 11.42 23 339001 375 29235128
Full blood count decreased 18.72 11.42 107 338917 15885 29219618
Atrioventricular block first degree 18.68 11.42 20 339004 5299 29230204
Pneumonia necrotising 18.58 11.42 27 338997 523 29234980
Aphthous ulcer 18.53 11.42 94 338930 3974 29231529
Splenic lesion 18.47 11.42 14 339010 120 29235383
Small intestinal obstruction 18.47 11.42 230 338794 12831 29222672
Azoospermia 18.45 11.42 23 339001 382 29235121
Mood altered 18.41 11.42 41 338983 8070 29227433
Pancreas transplant rejection 18.38 11.42 16 339008 170 29235333
Aspergilloma 18.38 11.42 20 339004 285 29235218
Drug intolerance 18.32 11.42 703 338321 47676 29187827
Blood stem cell harvest failure 18.26 11.42 7 339017 10 29235493
Pain 18.23 11.42 2238 336786 169194 29066309
Vocal cord dysfunction 18.19 11.42 15 339009 147 29235356
Complications of transplant surgery 18.18 11.42 25 338999 459 29235044
Haematocrit decreased 18.18 11.42 229 338795 28793 29206710
Lung abscess 18.07 11.42 64 338960 2302 29233201
Lymphoma 17.96 11.42 182 338842 9646 29225857
Sleep disorder due to general medical condition, insomnia type 17.95 11.42 43 338981 1235 29234268
Osteomyelitis 17.95 11.42 238 338786 13471 29222032
Cutaneous nocardiosis 17.93 11.42 14 339010 126 29235377
Generalised tonic-clonic seizure 17.89 11.42 137 338887 19002 29216501
Cutaneous mucormycosis 17.87 11.42 13 339011 104 29235399
Conjunctivitis allergic 17.86 11.42 29 338995 621 29234882
Central nervous system lymphoma 17.84 11.42 31 338993 703 29234800
Blood pressure diastolic abnormal 17.79 11.42 67 338957 2484 29233019
Autoinflammatory disease 17.77 11.42 10 339014 48 29235455
Atrial fibrillation 17.76 11.42 1010 338014 104636 29130867
Pneumonitis 17.75 11.42 434 338590 27610 29207893
Synovitis 17.72 11.42 197 338827 10693 29224810
Throat irritation 17.68 11.42 166 338858 8619 29226884
Dry mouth 17.63 11.42 162 338862 21622 29213881
Skin necrosis 17.62 11.42 108 338916 4904 29230599
Zoonotic bacterial infection 17.61 11.42 10 339014 49 29235454
Blood glucose increased 17.60 11.42 528 338496 58456 29177047
Red blood cell count decreased 17.57 11.42 198 338826 25404 29210099
Ankle deformity 17.57 11.42 17 339007 209 29235294
Systemic lupus erythematosus 17.57 11.42 67 338957 2499 29233004
Ill-defined disorder 17.54 11.42 208 338816 11470 29224033
BK polyomavirus test positive 17.52 11.42 8 339016 22 29235481
Hand deformity 17.47 11.42 59 338965 2071 29233432
Clear cell renal cell carcinoma 17.44 11.42 37 338987 978 29234525
Haemolysis 17.44 11.42 138 338886 6818 29228685
Prothrombin time prolonged 17.43 11.42 48 338976 8784 29226719
Social avoidant behaviour 17.37 11.42 6 339018 2936 29232567
Epstein-Barr virus test positive 17.32 11.42 25 338999 481 29235022
Cytomegalovirus nephritis 17.29 11.42 13 339011 110 29235393
Prescribed overdose 17.27 11.42 47 338977 8636 29226867
Plasmablastic lymphoma 17.26 11.42 17 339007 214 29235289
Swollen tongue 17.25 11.42 77 338947 12189 29223314
Colectomy total 17.19 11.42 13 339011 111 29235392
Kidney infection 17.16 11.42 102 338922 4581 29230922
Chest discomfort 17.14 11.42 667 338357 45316 29190187
Transitional cell carcinoma 17.13 11.42 55 338969 1880 29233623
Oxalosis 17.03 11.42 8 339016 24 29235479
Cardiac failure chronic 17.00 11.42 30 338994 6437 29229066
Incorrect route of product administration 16.93 11.42 65 338959 10736 29224767
Ileal stenosis 16.89 11.42 41 338983 1188 29234315
Colostomy 16.87 11.42 22 339002 383 29235120
Congenital hiatus hernia 16.86 11.42 23 339001 419 29235084
Emphysematous cystitis 16.86 11.42 10 339014 54 29235449
Graft versus host disease in liver 16.86 11.42 38 338986 1048 29234455
Renal impairment 16.85 11.42 761 338263 80572 29154931
Lymphadenopathy mediastinal 16.85 11.42 59 338965 2110 29233393
Peripheral arterial occlusive disease 16.83 11.42 20 339004 5056 29230447
Lower respiratory tract congestion 16.83 11.42 37 338987 1003 29234500
Drug specific antibody present 16.83 11.42 66 338958 2495 29233008
Dermatitis acneiform 16.79 11.42 23 339001 5468 29230035
Choriomeningitis lymphocytic 16.79 11.42 8 339016 25 29235478
Intervertebral disc space narrowing 16.77 11.42 31 338993 739 29234764
Chronic kidney disease 16.74 11.42 305 338719 36111 29199392
Erythema multiforme 16.72 11.42 40 338984 7677 29227826
Tuberculosis gastrointestinal 16.71 11.42 16 339008 194 29235309
Microsporidia infection 16.68 11.42 26 338998 537 29234966
Parathyroid gland enlargement 16.65 11.42 13 339011 117 29235386
Therapy non-responder 16.56 11.42 468 338556 30443 29205060
Metabolic acidosis 16.52 11.42 318 338706 37344 29198159
Oedema peripheral 16.51 11.42 995 338029 102562 29132941
Ventricular septal defect 16.48 11.42 10 339014 3519 29231984
Pneumonia klebsiella 16.46 11.42 67 338957 2577 29232926
Acute pulmonary histoplasmosis 16.44 11.42 14 339010 144 29235359
Bordetella infection 16.30 11.42 12 339012 98 29235405
Urinary tract infection bacterial 16.29 11.42 45 338979 1413 29234090
Right ventricular hypertrophy 16.24 11.42 39 338985 1122 29234381
Refractory cytopenia with unilineage dysplasia 16.23 11.42 23 339001 435 29235068
Necrotising herpetic retinopathy 16.22 11.42 7 339017 16 29235487
Atrioventricular block second degree 16.22 11.42 8 339016 3160 29232343
Polymyalgia rheumatica 16.21 11.42 40 338984 1171 29234332
Hydronephrosis 16.11 11.42 162 338862 8568 29226935
Renal tubular injury 16.11 11.42 29 338995 677 29234826
Plasma cell myeloma 16.09 11.42 314 338710 36801 29198702
Muscle swelling 16.05 11.42 20 339004 332 29235171
Secondary immunodeficiency 15.91 11.42 20 339004 335 29235168
Gait disturbance 15.87 11.42 683 338341 72666 29162837
Rheumatoid nodule 15.86 11.42 57 338967 2065 29233438
Rash maculo-papular 15.84 11.42 190 338834 24099 29211404
Hot flush 15.83 11.42 249 338775 14621 29220882
Granuloma 15.79 11.42 63 338961 2401 29233102
Abscess intestinal 15.76 11.42 44 338980 1390 29234113
Cardiac perforation 15.74 11.42 11 339013 82 29235421
Blood pressure systolic increased 15.70 11.42 276 338748 16569 29218934
Device occlusion 15.68 11.42 25 338999 5583 29229920
Epstein Barr virus positive mucocutaneous ulcer 15.63 11.42 18 339006 274 29235229
Coronary arterial stent insertion 15.63 11.42 13 339011 3884 29231619
Chromoblastomycosis 15.56 11.42 9 339015 46 29235457
Sinus node dysfunction 15.55 11.42 12 339012 3722 29231781
Rectal abscess 15.50 11.42 34 338990 920 29234583
Mediastinitis 15.49 11.42 27 338997 614 29234889
Rabies 15.49 11.42 6 339018 9 29235494
Neurocryptococcosis 15.49 11.42 6 339018 9 29235494
Drug level above therapeutic 15.44 11.42 77 338947 3233 29232270
Empyema 15.42 11.42 68 338956 2711 29232792
Phospholipidosis 15.41 11.42 9 339015 47 29235456
Renal tubular necrosis 15.35 11.42 240 338784 14075 29221428
Fear of injection 15.31 11.42 31 338993 792 29234711
Petit mal epilepsy 15.31 11.42 6 339018 2716 29232787
Donor specific antibody present 15.02 11.42 11 339013 89 29235414
Cutaneous tuberculosis 15.02 11.42 11 339013 89 29235414
Blood potassium decreased 15.01 11.42 112 338912 15622 29219881
Eosinophilic bronchitis 15.00 11.42 14 339010 164 29235339
Pericarditis infective 14.97 11.42 9 339015 50 29235453
Acarodermatitis 14.96 11.42 20 339004 357 29235146
Anaphylactic reaction 14.96 11.42 224 338800 27349 29208154
Chronic granulomatous disease 14.90 11.42 7 339017 21 29235482
Human herpes virus 8 test positive 14.90 11.42 7 339017 21 29235482
Forced vital capacity decreased 14.89 11.42 27 338997 634 29234869
Meningoencephalitis amoebic 14.85 11.42 12 339012 114 29235389
Neuroendocrine carcinoma of the skin 14.83 11.42 26 338998 594 29234909
Blood stem cell transplant failure 14.82 11.42 21 339003 397 29235106
Chromaturia 14.80 11.42 86 338938 12716 29222787
Heart rate increased 14.79 11.42 566 338458 38372 29197131
Anal abscess 14.75 11.42 107 338917 5144 29230359
Disseminated mucormycosis 14.73 11.42 19 339005 327 29235176
Eye abscess 14.72 11.42 13 339011 141 29235362
Logorrhoea 14.71 11.42 4 339020 2284 29233219
Central nervous system vasculitis 14.68 11.42 20 339004 364 29235139
Cold sweat 14.66 11.42 52 338972 8790 29226713
Vertigo 14.64 11.42 170 338854 21691 29213812
Enterocolonic fistula 14.64 11.42 11 339013 93 29235410
Taste disorder 14.61 11.42 20 339004 4756 29230747
Device leakage 14.60 11.42 18 339006 4477 29231026
Musculoskeletal pain 14.59 11.42 435 338589 28518 29206985
Ophthalmic herpes zoster 14.59 11.42 29 338995 731 29234772
Immunodeficiency 14.57 11.42 94 338930 4346 29231157
Abdominal wall abscess 14.55 11.42 22 339002 442 29235061
Forced expiratory volume 14.54 11.42 11 339013 94 29235409
B-cell lymphoma 14.53 11.42 84 338940 3734 29231769
Psychomotor retardation 14.51 11.42 8 339016 2968 29232535
Colour blindness acquired 14.48 11.42 10 339014 73 29235430
Dysmorphism 14.47 11.42 8 339016 2963 29232540
Lip ulceration 14.46 11.42 28 338996 692 29234811
Drug resistance 14.44 11.42 336 338688 21204 29214299
Renal vein thrombosis 14.43 11.42 13 339011 145 29235358
Maternal drugs affecting foetus 14.40 11.42 14 339010 3879 29231624
Drug level abnormal 14.36 11.42 11 339013 96 29235407
Anhedonia 14.30 11.42 39 338985 7161 29228342
Fluoride increased 14.30 11.42 9 339015 55 29235448
Symptom masked 14.29 11.42 24 339000 529 29234974
Post procedural diarrhoea 14.28 11.42 8 339016 38 29235465
Bronchitis 14.26 11.42 537 338487 36331 29199172
Bacterial infection 14.23 11.42 218 338806 12730 29222773
Hyperammonaemia 14.23 11.42 27 338997 5636 29229867
Respiratory tract congestion 14.20 11.42 106 338918 5143 29230360
Dementia 14.19 11.42 77 338947 11581 29223922
Antisynthetase syndrome 14.17 11.42 9 339015 56 29235447
Capnocytophaga infection 14.17 11.42 9 339015 56 29235447
Reactive gastropathy 14.16 11.42 13 339011 149 29235354
Autism spectrum disorder 14.15 11.42 3 339021 2029 29233474
Postoperative wound infection 14.09 11.42 90 338934 4146 29231357
Mitochondrial toxicity 14.09 11.42 5 339019 2406 29233097
Eye infection fungal 14.08 11.42 18 339006 307 29235196
Torsade de pointes 14.06 11.42 35 338989 6626 29228877
Bacteroides infection 14.05 11.42 10 339014 77 29235426
Blood creatinine increased 14.04 11.42 815 338209 84287 29151216
Chronic myelomonocytic leukaemia 14.04 11.42 24 339000 537 29234966
Exposure via ingestion 14.01 11.42 3 339021 2015 29233488
Hypotonia 14.00 11.42 37 338987 6865 29228638
Rhonchi 13.99 11.42 46 338978 1592 29233911
Disseminated coccidioidomycosis 13.99 11.42 5 339019 5 29235498
Pulmonary cavitation 13.99 11.42 29 338995 754 29234749
Clostridium difficile colitis 13.97 11.42 221 338803 12991 29222512
Encephalopathy 13.96 11.42 261 338763 30782 29204721
Osteomyelitis acute 13.93 11.42 15 339009 211 29235292
Salivary duct obstruction 13.92 11.42 4 339020 0 29235503
Erysipelothrix infection 13.92 11.42 4 339020 0 29235503
Pyogenic granuloma 13.88 11.42 15 339009 212 29235291
Sudden cardiac death 13.87 11.42 10 339014 3212 29232291
Electrocardiogram QRS complex prolonged 13.84 11.42 16 339008 4094 29231409
Histology abnormal 13.83 11.42 17 339007 278 29235225
Nephritis haemorrhagic 13.82 11.42 6 339018 14 29235489
Biliary hamartoma 13.82 11.42 6 339018 14 29235489
Glomerulonephritis membranoproliferative 13.81 11.42 20 339004 386 29235117
Vertebroplasty 13.80 11.42 7 339017 26 29235477
Splenic marginal zone lymphoma 13.80 11.42 7 339017 26 29235477
Opportunistic infection 13.80 11.42 43 338981 1446 29234057
Haemorrhagic stroke 13.79 11.42 29 338995 5827 29229676
Anger 13.77 11.42 71 338953 10819 29224684
Malignant melanoma 13.76 11.42 134 338890 7027 29228476
Liver injury 13.75 11.42 87 338937 12603 29222900
Atrioventricular block 13.73 11.42 38 338986 6944 29228559
Rectal tenesmus 13.72 11.42 26 338998 632 29234871
Cytopenia 13.68 11.42 173 338851 9686 29225817
Disseminated trichosporonosis 13.66 11.42 8 339016 42 29235461
Carotid artery aneurysm 13.66 11.42 8 339016 42 29235461
Pancytopenia 13.66 11.42 1119 337905 82049 29153454
Angina unstable 13.65 11.42 71 338953 10794 29224709
T-cell type acute leukaemia 13.65 11.42 10 339014 81 29235422
Graft thrombosis 13.62 11.42 16 339008 249 29235254
Bone marrow reticulin fibrosis 13.62 11.42 13 339011 157 29235346
Pancreatitis acute 13.61 11.42 197 338827 24188 29211315
Laryngeal mass 13.61 11.42 7 339017 27 29235476
Chronic myeloid leukaemia 13.60 11.42 52 338972 1942 29233561
Total lung capacity decreased 13.58 11.42 24 339000 552 29234951
Device adhesion issue 13.57 11.42 3 339021 1971 29233532
Hepatic cancer 13.56 11.42 34 338990 6422 29229081
Infective uveitis 13.53 11.42 5 339019 6 29235497
Respiratory fume inhalation disorder 13.53 11.42 5 339019 6 29235497
Intestinal stenosis 13.51 11.42 50 338974 1838 29233665
Intervertebral disc degeneration 13.51 11.42 105 338919 5159 29230344
Retroperitoneal lymphadenopathy 13.48 11.42 28 338996 729 29234774
Intracranial pressure increased 13.48 11.42 77 338947 3408 29232095
Faecaloma 13.47 11.42 17 339007 4185 29231318
Skeletal injury 13.44 11.42 18 339006 322 29235181
Blindness 13.44 11.42 203 338821 11820 29223683
Acute erythroid leukaemia 13.43 11.42 13 339011 160 29235343
Incision site pain 13.42 11.42 48 338976 1735 29233768
Pericardial fibrosis 13.42 11.42 7 339017 28 29235475
Herpes simplex encephalitis 13.38 11.42 17 339007 288 29235215
Road traffic accident 13.35 11.42 114 338910 15447 29220056
Rhinalgia 13.34 11.42 19 339005 361 29235142
Metapneumovirus infection 13.29 11.42 25 338999 604 29234899
Red blood cell sedimentation rate abnormal 13.27 11.42 57 338967 2246 29233257
Histoplasmosis cutaneous 13.27 11.42 6 339018 16 29235487
Disorder of orbit 13.26 11.42 10 339014 85 29235418
Atypical mycobacterial pneumonia 13.24 11.42 12 339012 135 29235368
Disseminated varicella zoster vaccine virus infection 13.23 11.42 8 339016 45 29235458
Nystagmus 13.23 11.42 18 339006 4291 29231212
Thyroid gland abscess 13.22 11.42 9 339015 64 29235439
IgA nephropathy 13.18 11.42 34 338990 1024 29234479
Myelosuppression 13.11 11.42 205 338819 12022 29223481
Coordination abnormal 13.06 11.42 40 338984 7074 29228429
Lupus-like syndrome 13.05 11.42 56 338968 2206 29233297
Nodular regenerative hyperplasia 13.04 11.42 26 338998 657 29234846
Renal cell carcinoma stage I 13.01 11.42 6 339018 17 29235486
Chemical peritonitis 13.01 11.42 11 339013 112 29235391
Hepatosplenomegaly 13.01 11.42 80 338944 3637 29231866
Limb deformity 13.00 11.42 22 339002 488 29235015
Lip swelling 12.98 11.42 86 338938 12324 29223179
Morganella infection 12.92 11.42 21 339003 450 29235053
Application site erythema 12.89 11.42 4 339020 2095 29233408
Ossicle disorder 12.87 11.42 7 339017 31 29235472
Post-acute COVID-19 syndrome 12.87 11.42 7 339017 31 29235472
Large intestinal ulcer 12.86 11.42 46 338978 1663 29233840
Acute lung injury 12.82 11.42 39 338985 1294 29234209
Type 2 lepra reaction 12.81 11.42 13 339011 170 29235333
Varicella zoster pneumonia 12.78 11.42 9 339015 68 29235435
Enuresis 12.74 11.42 4 339020 2080 29233423
Cytomegalovirus enteritis 12.73 11.42 20 339004 416 29235087
Hepatitis C RNA increased 12.73 11.42 16 339008 268 29235235
Meningitis haemophilus 12.71 11.42 5 339019 8 29235495
Neuropathy peripheral 12.67 11.42 675 338349 70352 29165151
Abscess limb 12.67 11.42 71 338953 3120 29232383
Transient ischaemic attack 12.64 11.42 189 338835 23081 29212422
Muscle abscess 12.63 11.42 21 339003 459 29235044
Immune reconstitution inflammatory syndrome 12.63 11.42 141 338883 7661 29227842
Cutaneous T-cell lymphoma 12.60 11.42 38 338986 1255 29234248
Drug ineffective for unapproved indication 12.57 11.42 231 338793 13983 29221520
Sebaceous hyperplasia 12.57 11.42 8 339016 50 29235453
Secretion discharge 12.53 11.42 87 338937 4123 29231380
Stupor 12.50 11.42 8 339016 2736 29232767
Loss of therapeutic response 12.49 11.42 17 339007 309 29235194
Orbital myositis 12.48 11.42 11 339013 119 29235384
Ileal ulcer 12.48 11.42 22 339002 505 29234998
Pulmonary sarcoidosis 12.48 11.42 22 339002 505 29234998
Mycetoma mycotic 12.47 11.42 9 339015 71 29235432
Grip strength decreased 12.46 11.42 56 338968 2251 29233252
Infective thrombosis 12.44 11.42 8 339016 51 29235452
Ischaemic stroke 12.42 11.42 120 338904 15857 29219646
Perirectal abscess 12.39 11.42 41 338983 1424 29234079
Appendiceal abscess 12.38 11.42 10 339014 95 29235408
Gastrointestinal fistula 12.37 11.42 18 339006 349 29235154
Arteriospasm coronary 12.36 11.42 7 339017 2558 29232945
Inappropriate antidiuretic hormone secretion 12.34 11.42 74 338950 10858 29224645
Drug specific antibody absent 12.32 11.42 8 339016 52 29235451
Epidural lipomatosis 12.31 11.42 26 338998 685 29234818
Mucocutaneous leishmaniasis 12.27 11.42 9 339015 73 29235430
Eschar 12.26 11.42 24 339000 598 29234905
Behaviour disorder 12.26 11.42 14 339010 3602 29231901
Skin papilloma 12.25 11.42 46 338978 1703 29233800
Diabetic neuropathy 12.22 11.42 15 339009 3738 29231765
Metastases to bone 12.20 11.42 170 338854 9728 29225775
Herpes dermatitis 12.20 11.42 8 339016 53 29235450
Aplasia pure red cell 12.19 11.42 106 338918 5385 29230118
Sweat gland tumour 12.17 11.42 19 339005 393 29235110
Brain oedema 12.13 11.42 86 338938 12134 29223369
Total lung capacity abnormal 12.12 11.42 11 339013 124 29235379
Gastric haemorrhage 12.11 11.42 60 338964 9237 29226266
Systemic mycosis 12.11 11.42 38 338986 1283 29234220
Rhinitis 12.09 11.42 95 338929 4683 29230820
Necrotising soft tissue infection 12.08 11.42 8 339016 54 29235449
Hormone-refractory prostate cancer 12.07 11.42 24 339000 605 29234898
Urinoma 12.07 11.42 13 339011 183 29235320
Diffuse idiopathic skeletal hyperostosis 12.07 11.42 7 339017 36 29235467
Gastroenteritis sapovirus 12.05 11.42 11 339013 125 29235378
Skin ulcer 12.05 11.42 292 338732 18548 29216955
Meningitis noninfective 12.02 11.42 5 339019 10 29235493
Bone marrow tumour cell infiltration 12.02 11.42 5 339019 10 29235493
Serum sickness 12.02 11.42 46 338978 1719 29233784
Papilloma viral infection 12 11.42 20 339004 438 29235065
Vascular injury 11.99 11.42 15 339009 250 29235253
Pneumonia acinetobacter 11.98 11.42 9 339015 76 29235427
Hepatic cytolysis 11.98 11.42 52 338972 8295 29227208
Skin striae 11.97 11.42 20 339004 439 29235064
Sensory disturbance 11.96 11.42 29 338995 5540 29229963
Subdural haemorrhage 11.94 11.42 9 339015 2826 29232677
Respiratory tract infection fungal 11.91 11.42 25 338999 656 29234847
Odynophagia 11.90 11.42 93 338931 4577 29230926
Necrotising fasciitis fungal 11.89 11.42 6 339018 22 29235481
Prophylaxis against transplant rejection 11.89 11.42 6 339018 22 29235481
Infection parasitic 11.89 11.42 9 339015 77 29235426
Acute febrile neutrophilic dermatosis 11.85 11.42 33 338991 1041 29234462
Large intestine anastomosis 11.85 11.42 8 339016 56 29235447
Eosinophil count increased 11.85 11.42 133 338891 7236 29228267
Intestinal fistula 11.84 11.42 29 338995 845 29234658
Traumatic lung injury 11.80 11.42 35 338989 1145 29234358
Ureaplasma infection 11.80 11.42 13 339011 188 29235315
Morphoea 11.76 11.42 12 339012 158 29235345
Neurosarcoidosis 11.76 11.42 12 339012 158 29235345
Forced expiratory flow decreased 11.76 11.42 12 339012 158 29235345
Endocarditis bacterial 11.76 11.42 28 338996 801 29234702
Chronic graft versus host disease in liver 11.75 11.42 17 339007 328 29235175
Inadequate analgesia 11.74 11.42 8 339016 2646 29232857
Actinic keratosis 11.72 11.42 79 338945 3707 29231796
Endocarditis Q fever 11.72 11.42 4 339020 3 29235500
Nasal mucosal discolouration 11.72 11.42 4 339020 3 29235500
Peripheral nerve palsy 11.72 11.42 4 339020 3 29235500
Renal transplant 11.71 11.42 43 338981 1575 29233928
Fungating wound 11.69 11.42 6 339018 23 29235480
Blood thyroid stimulating hormone increased 11.68 11.42 11 339013 3094 29232409
Ulcer 11.67 11.42 128 338896 6923 29228580
Gastrointestinal mucormycosis 11.66 11.42 10 339014 104 29235399
Skin atrophy 11.65 11.42 45 338979 1689 29233814
Bronchoscopy abnormal 11.63 11.42 7 339017 39 29235464
Musculoskeletal disorder 11.55 11.42 101 338923 5139 29230364
Tongue necrosis 11.50 11.42 6 339018 24 29235479
Joint range of motion decreased 11.49 11.42 113 338911 5941 29229562
Osteoporotic fracture 11.48 11.42 31 338993 960 29234543
Blood glucose decreased 11.47 11.42 86 338938 11983 29223520
Diaphragm muscle weakness 11.45 11.42 11 339013 134 29235369
Loss of libido 11.45 11.42 6 339018 2290 29233213
Atrioventricular block complete 11.44 11.42 50 338974 7961 29227542
Hepatitis viral 11.44 11.42 21 339003 498 29235005
Cytomegalovirus syndrome 11.43 11.42 10 339014 107 29235396
Oesophageal infection 11.42 11.42 15 339009 263 29235240

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2056.38 10.76 241 830948 224173 63443370
Drug ineffective 1647.40 10.76 17274 813915 822973 62844570
Rheumatoid arthritis 1494.70 10.76 5087 826102 159207 63508336
Drug abuse 1095.88 10.76 192 830997 132182 63535361
Toxicity to various agents 1085.56 10.76 1888 829301 361625 63305918
Colitis ulcerative 959.42 10.76 1328 829861 21700 63645843
Asthma 881.40 10.76 2967 828222 92258 63575285
Off label use 842.86 10.76 12110 819079 620696 63046847
Death 840.77 10.76 3289 827900 479416 63188127
Overdose 807.79 10.76 531 830658 159035 63508508
Intentional overdose 747.51 10.76 129 831060 89815 63577728
Post transplant lymphoproliferative disorder 707.58 10.76 738 830451 8806 63658737
Joint swelling 695.04 10.76 4955 826234 210427 63457116
Product use in unapproved indication 677.42 10.76 4242 826947 172376 63495167
Condition aggravated 665.45 10.76 7530 823659 364896 63302647
Therapeutic product effect incomplete 624.49 10.76 2817 828372 100665 63566878
Bradycardia 602.84 10.76 390 830799 117829 63549714
Arthralgia 581.27 10.76 8449 822740 433811 63233732
Treatment failure 576.80 10.76 3002 828187 113814 63553729
Nocardiosis 556.05 10.76 474 830715 4293 63663250
Wheezing 543.10 10.76 2268 828921 78311 63589232
Electrocardiogram QT prolonged 522.74 10.76 185 831004 79263 63588280
Obstructive airways disorder 473.66 10.76 972 830217 22213 63645330
Depressed level of consciousness 452.81 10.76 242 830947 81194 63586349
Aspergillus infection 448.18 10.76 778 830411 15601 63651942
Acute kidney injury 445.51 10.76 3678 827511 445562 63221981
Transplant rejection 444.49 10.76 802 830387 16599 63650944
Cytomegalovirus infection 439.31 10.76 1262 829927 35937 63631606
Hypotension 439.02 10.76 2990 828199 377984 63289559
Intentional product use issue 412.90 10.76 2365 828824 92999 63574544
Cardio-respiratory arrest 409.26 10.76 398 830791 97995 63569548
Fall 408.01 10.76 3424 827765 413402 63254141
Suicide attempt 405.19 10.76 204 830985 70803 63596740
Arthropathy 404.93 10.76 2809 828380 118158 63549385
Polyomavirus-associated nephropathy 404.30 10.76 401 830788 4487 63663056
Therapeutic product effect decreased 401.80 10.76 2705 828484 112646 63554897
Kidney transplant rejection 398.37 10.76 550 830639 8961 63658582
Pneumocystis jirovecii pneumonia 395.08 10.76 1006 830183 26628 63640915
Drug interaction 385.86 10.76 2906 828283 359177 63308366
Hyponatraemia 385.72 10.76 835 830354 147504 63520039
Loss of personal independence in daily activities 373.50 10.76 1885 829304 70569 63596974
Rhabdomyolysis 367.81 10.76 383 830806 91343 63576200
Hypoglycaemia 367.66 10.76 369 830820 89523 63578020
Contraindicated product administered 366.23 10.76 2513 828676 105316 63562227
Histoplasmosis disseminated 360.07 10.76 257 830932 1741 63665802
Constipation 359.53 10.76 1625 829564 227712 63439831
Strongyloidiasis 355.82 10.76 305 830884 2785 63664758
Seizure 344.30 10.76 1056 830133 165836 63501707
Productive cough 335.11 10.76 1843 829346 71360 63596183
Somnolence 334.33 10.76 1418 829771 202227 63465316
Drug intolerance 332.98 10.76 3797 827392 184195 63483348
Loss of consciousness 332.18 10.76 903 830286 147462 63520081
Cardiac arrest 327.73 10.76 961 830228 153103 63514440
Blood pressure fluctuation 322.46 10.76 1425 829764 50446 63617097
Dizziness 321.48 10.76 3771 827418 426392 63241151
Epstein-Barr virus infection 311.89 10.76 570 830619 11918 63655625
Full blood count abnormal 306.47 10.76 962 830227 28795 63638748
Vomiting 298.61 10.76 5152 826037 545965 63121578
Confusional state 295.77 10.76 2059 829130 259085 63408458
Osteoporosis 291.73 10.76 1195 829994 40885 63626658
Systemic lupus erythematosus 290.23 10.76 1853 829336 75759 63591784
Hepatic function abnormal 287.86 10.76 243 830946 64070 63603473
Sleep disorder due to a general medical condition 282.08 10.76 433 830756 7801 63659742
Synovitis 281.34 10.76 2213 828976 96877 63570666
Respiratory arrest 279.39 10.76 168 831021 52817 63614726
Infusion related reaction 273.90 10.76 3283 827906 161184 63506359
Agitation 270.33 10.76 451 830738 87916 63579627
Disease recurrence 267.96 10.76 955 830234 30555 63636988
Serotonin syndrome 264.36 10.76 88 831101 39194 63628349
Cryptococcosis 263.78 10.76 245 830944 2510 63665033
Histoplasmosis 260.59 10.76 213 830976 1809 63665734
Phaeohyphomycosis 260.26 10.76 166 831023 908 63666635
Swelling 259.31 10.76 3181 828008 157037 63510506
Sputum discoloured 251.05 10.76 646 830543 17210 63650333
Sinusitis 250.04 10.76 2929 828260 142999 63524544
Syncope 248.66 10.76 1114 830075 156521 63511022
Forced expiratory volume decreased 247.85 10.76 370 830819 6497 63661046
Musculoskeletal stiffness 247.39 10.76 2552 828637 120654 63546889
Weight increased 247.36 10.76 3993 827196 209355 63458188
Cytomegalovirus viraemia 246.47 10.76 475 830714 10353 63657190
Sedation 245.87 10.76 113 831076 41349 63626194
Pain 243.28 10.76 9066 822123 544445 63123098
Lactic acidosis 239.93 10.76 262 830927 61148 63606395
Dehydration 231.83 10.76 1737 829452 215026 63452517
Hand deformity 228.11 10.76 1488 829701 61283 63606260
Intentional product misuse 225.76 10.76 364 830825 71931 63595612
Intentional self-injury 223.70 10.76 50 831139 28994 63638549
Neuroleptic malignant syndrome 223.35 10.76 29 831160 24967 63642576
Nausea 223.06 10.76 8088 823101 777712 62889831
Aggression 222.93 10.76 162 831027 46070 63621473
Blood creatine phosphokinase increased 220.95 10.76 257 830932 58301 63609242
Arthritis 220.64 10.76 1840 829349 81974 63585569
Product use issue 217.55 10.76 2946 828243 148769 63518774
Hallucination 216.65 10.76 378 830811 72410 63595133
Nasopharyngitis 214.81 10.76 3636 827553 192437 63475106
Cough 213.55 10.76 5249 825940 296899 63370644
Myocardial infarction 213.38 10.76 1257 829932 164564 63502979
Pemphigus 211.55 10.76 1424 829765 59277 63608266
Hyperkalaemia 209.80 10.76 638 830551 100491 63567052
Anaemia 208.25 10.76 3529 827660 375151 63292392
Orthostatic hypotension 207.44 10.76 178 831011 46560 63620983
Decreased appetite 202.48 10.76 2485 828704 278804 63388739
Infection 200.16 10.76 3422 827767 181458 63486085
International normalised ratio increased 198.82 10.76 454 830735 78713 63588830
Hypokalaemia 198.58 10.76 851 830338 121052 63546491
White blood cell count decreased 197.01 10.76 1208 829981 156629 63510914
Coma 196.96 10.76 532 830657 87083 63580460
COVID-19 196.66 10.76 1476 829713 63664 63603879
Varicella zoster virus infection 193.98 10.76 245 830944 3643 63663900
Peripheral swelling 193.09 10.76 3776 827413 205377 63462166
Cardiac failure congestive 188.23 10.76 953 830236 129627 63537916
Respiratory depression 187.46 10.76 37 831152 23406 63644137
Mucormycosis 185.76 10.76 337 830852 7004 63660539
Device expulsion 185.34 10.76 26 831163 21110 63646433
Suicidal ideation 185.21 10.76 360 830829 66182 63601361
Cognitive disorder 182.91 10.76 266 830923 54821 63612722
Unresponsive to stimuli 176.66 10.76 234 830955 50159 63617384
Dysarthria 175.43 10.76 310 830879 59096 63608447
Cushingoid 174.85 10.76 335 830854 7268 63660275
Palmar-plantar erythrodysaesthesia syndrome 170.16 10.76 79 831110 28740 63638803
Cerebrovascular accident 170.11 10.76 1056 830133 136527 63531016
BK virus infection 168.52 10.76 325 830864 7087 63660456
Drug level below therapeutic 168.16 10.76 324 830865 7060 63660483
Balance disorder 167.35 10.76 539 830650 83387 63584156
Cardiac failure 167.32 10.76 1009 830180 131364 63536179
Complications of transplanted kidney 167.10 10.76 272 830917 5163 63662380
Inflammation 166.25 10.76 1423 829766 63877 63603666
Poisoning 165.84 10.76 39 831150 21840 63645703
Chronic allograft nephropathy 162.78 10.76 144 831045 1377 63666166
Brain abscess 162.08 10.76 233 830956 3948 63663595
Trichodysplasia spinulosa 162.01 10.76 106 831083 610 63666933
Frequent bowel movements 161.84 10.76 562 830627 17743 63649800
Circulatory collapse 161.59 10.76 119 831070 33613 63633930
Mycobacterial infection 161.47 10.76 196 830993 2792 63664751
Bronchiectasis 161.41 10.76 474 830715 13666 63653877
Dyskinesia 159.51 10.76 163 831026 39225 63628318
Gastrointestinal haemorrhage 156.69 10.76 1029 830160 131283 63536260
Acute myocardial infarction 156.19 10.76 424 830765 69294 63598249
Neutrophil count decreased 155.86 10.76 493 830696 76703 63590840
Altered state of consciousness 154.45 10.76 156 831033 37746 63629797
Smooth muscle cell neoplasm 152.86 10.76 110 831079 756 63666787
Cytomegalovirus colitis 152.41 10.76 219 830970 3709 63663834
Bronchopulmonary aspergillosis 151.76 10.76 566 830623 18519 63649024
Platelet count decreased 149.82 10.76 1409 829780 166302 63501241
Angioedema 149.25 10.76 362 830827 61459 63606084
Drug withdrawal syndrome 149.10 10.76 111 831078 31180 63636363
Tachycardia 148.93 10.76 1222 829967 148357 63519186
Faecal calprotectin increased 145.74 10.76 206 830983 3434 63664109
Rebound effect 145.67 10.76 242 830947 4675 63662868
Malignant neoplasm progression 145.47 10.76 855 830334 112016 63555527
Delirium 145.31 10.76 434 830755 68760 63598783
Haematemesis 142.66 10.76 241 830948 46758 63620785
Cerebral infarction 142.43 10.76 192 830997 40852 63626691
Tremor 141.71 10.76 1224 829965 147006 63520537
Herpes zoster 140.25 10.76 1600 829589 77587 63589956
Glossodynia 139.88 10.76 1361 829828 63335 63604208
Mycobacterium avium complex infection 138.93 10.76 210 830979 3730 63663813
West Nile viral infection 138.37 10.76 106 831083 811 63666732
Sensitivity to weather change 137.73 10.76 282 830907 6432 63661111
Pericarditis 136.56 10.76 1318 829871 61198 63606345
Wrong technique in product usage process 135.38 10.76 409 830780 64565 63602978
Sopor 134.03 10.76 111 831078 29550 63637993
Epistaxis 133.11 10.76 731 830458 97400 63570143
Human herpesvirus 8 infection 131.95 10.76 110 831079 963 63666580
Diffuse large B-cell lymphoma recurrent 131.86 10.76 182 831007 2964 63664579
Septic shock 131.00 10.76 1997 829192 103440 63564103
General physical health deterioration 130.15 10.76 1852 829337 202573 63464970
Restlessness 129.26 10.76 195 830994 39590 63627953
Renal transplant failure 129.12 10.76 131 831058 1509 63666034
Inappropriate schedule of product administration 128.52 10.76 1783 829406 90503 63577040
Metabolic acidosis 128.43 10.76 475 830714 70483 63597060
Melaena 127.34 10.76 316 830873 53232 63614311
Anti-cyclic citrullinated peptide antibody positive 126.12 10.76 1080 830109 48482 63619061
Multiple sclerosis relapse 124.79 10.76 211 830978 40924 63626619
Infection reactivation 124.37 10.76 142 831047 1888 63665655
Posterior reversible encephalopathy syndrome 123.15 10.76 604 830585 22342 63645201
Steroid dependence 122.50 10.76 73 831116 346 63667197
Blood pressure systolic increased 121.86 10.76 1070 830119 48383 63619160
Aspartate aminotransferase increased 121.80 10.76 973 830216 118815 63548728
Focal segmental glomerulosclerosis 121.42 10.76 169 831020 2775 63664768
Coronary artery disease 121.25 10.76 387 830802 60046 63607497
Hyperhidrosis 119.62 10.76 1031 830158 123889 63543654
Extrapyramidal disorder 119.52 10.76 51 831138 19501 63648042
Miosis 119.47 10.76 15 831174 13251 63654292
Sedation complication 119.06 10.76 3 831186 10351 63657192
Disorientation 118.79 10.76 348 830841 55480 63612063
JC virus infection 118.56 10.76 179 831010 3176 63664367
Immunosuppressant drug level increased 118.36 10.76 278 830911 6981 63660562
Graft loss 117.18 10.76 100 831089 907 63666636
Red blood cell sedimentation rate increased 116.86 10.76 746 830443 30489 63637054
Haematotoxicity 115.80 10.76 398 830791 12498 63655045
Gamma-glutamyltransferase increased 115.56 10.76 286 830903 48224 63619319
Haemophagocytic lymphohistiocytosis 114.93 10.76 491 830698 17118 63650425
Blood alkaline phosphatase increased 114.60 10.76 358 830831 55921 63611622
Therapeutic response shortened 114.25 10.76 339 830850 9831 63657712
Meningitis cryptococcal 114.18 10.76 166 831023 2843 63664700
Hepatitis B reactivation 113.15 10.76 216 830973 4673 63662870
Schizophrenia 112.81 10.76 8 831181 11160 63656383
Disturbance in attention 112.75 10.76 224 830965 40850 63626693
Labelled drug-drug interaction medication error 112.09 10.76 73 831116 21989 63645554
Drug reaction with eosinophilia and systemic symptoms 111.73 10.76 343 830846 53874 63613669
Product prescribing error 111.58 10.76 176 831013 35093 63632450
Progressive multifocal leukoencephalopathy 109.60 10.76 496 830693 17736 63649807
Muscle rigidity 109.36 10.76 44 831145 17429 63650114
Blood bilirubin increased 108.98 10.76 378 830811 57175 63610368
Accidental overdose 108.51 10.76 165 831024 33392 63634151
Lethargy 108.48 10.76 523 830666 72071 63595472
Red blood cell sedimentation rate abnormal 108.23 10.76 457 830732 15849 63651694
Gastrointestinal disorder 107.94 10.76 1690 829499 88019 63579524
Alanine aminotransferase increased 106.92 10.76 1210 829979 137821 63529722
Sinus bradycardia 106.79 10.76 83 831106 22810 63644733
Blastomycosis 106.60 10.76 71 831118 423 63667120
Dystonia 106.39 10.76 55 831134 18810 63648733
Blood pressure increased 106.10 10.76 2944 828245 169608 63497935
Subdural haematoma 105.95 10.76 123 831066 27931 63639612
Parvovirus B19 infection 104.99 10.76 103 831086 1136 63666407
Clostridium difficile infection 104.97 10.76 812 830377 35351 63632192
Parkinsonism 104.34 10.76 28 831161 14345 63653198
Abnormal behaviour 104.27 10.76 170 831019 33452 63634091
Nasal polyps 104.03 10.76 176 831013 3453 63664090
Urinary retention 103.01 10.76 309 830880 48892 63618651
Stevens-Johnson syndrome 102.68 10.76 177 831012 34072 63633471
Hypomagnesaemia 102.45 10.76 204 830985 37172 63630371
Respiratory disorder 102.14 10.76 806 830383 35305 63632238
Respiratory tract congestion 101.11 10.76 445 830744 15720 63651823
Product substitution issue 100.84 10.76 52 831137 17809 63649734
Epstein-Barr viraemia 100.58 10.76 120 831069 1677 63665866
American trypanosomiasis 99.76 10.76 59 831130 275 63667268
Diabetes mellitus 99.41 10.76 1301 829888 65173 63602370
Blood immunoglobulin E increased 99.22 10.76 178 831011 3666 63663877
Substance abuse 98.87 10.76 5 831184 9287 63658256
Cerebral haemorrhage 98.46 10.76 333 830856 50757 63616786
Therapeutic reaction time decreased 98.39 10.76 123 831066 1809 63665734
Lung transplant rejection 96.94 10.76 102 831087 1230 63666313
Mydriasis 96.74 10.76 38 831151 15274 63652269
Wound 96.33 10.76 1452 829737 75025 63592518
Nasal congestion 96.18 10.76 1184 830005 58474 63609069
Mobility decreased 95.75 10.76 1597 829592 84243 63583300
Ill-defined disorder 95.35 10.76 927 830262 43125 63624418
Diabetic ketoacidosis 95.30 10.76 148 831041 29697 63637846
Joint stiffness 95.19 10.76 695 830494 29709 63637834
Diarrhoea 95.00 10.76 8022 823167 714682 62952861
Candida infection 94.84 10.76 712 830477 30707 63636836
Therapy partial responder 94.41 10.76 319 830870 9929 63657614
Poisoning deliberate 94.38 10.76 28 831161 13430 63654113
Steroid diabetes 93.87 10.76 142 831047 2524 63665019
Rheumatoid nodule 93.04 10.76 366 830823 12285 63655258
Pseudomonas infection 92.61 10.76 466 830723 17417 63650126
Arrhythmia 92.18 10.76 360 830829 52584 63614959
Therapeutic response decreased 92.17 10.76 1054 830135 51134 63616409
Lower respiratory tract infection 91.91 10.76 1722 829467 92892 63574651
Diffuse large B-cell lymphoma 91.50 10.76 318 830871 10043 63657500
Cataract 91.30 10.76 1037 830152 50225 63617318
Alternaria infection 91.00 10.76 69 831120 519 63667024
Dysgeusia 90.43 10.76 307 830882 46740 63620803
Secondary immunodeficiency 90.16 10.76 141 831048 2583 63664960
Dust allergy 90.09 10.76 88 831101 965 63666578
Weight decreased 89.42 10.76 4521 826668 281218 63386325
Tardive dyskinesia 88.74 10.76 8 831181 9170 63658373
Ascites 88.44 10.76 454 830735 61547 63605996
Heart rate increased 88.42 10.76 1774 829415 96901 63570642
Epidermodysplasia verruciformis 88.23 10.76 45 831144 146 63667397
Ventricular tachycardia 88.05 10.76 194 830995 34071 63633472
Depression 88.03 10.76 1748 829441 181543 63486000
Pneumonia aspiration 87.99 10.76 428 830761 58843 63608700
Oedema peripheral 87.89 10.76 2051 829138 208266 63459277
Blood calcium decreased 87.19 10.76 121 831068 25433 63642110
Vaccination failure 86.78 10.76 80 831109 811 63666732
Disseminated cryptococcosis 86.66 10.76 104 831085 1463 63666080
Medication error 86.20 10.76 341 830848 49625 63617918
Hepatitis B 85.90 10.76 257 830932 7488 63660055
C-reactive protein abnormal 85.85 10.76 655 830534 28392 63639151
Epilepsy 85.21 10.76 191 830998 33340 63634203
Suspected suicide 85.15 10.76 7 831182 8647 63658896
Bacillary angiomatosis 84.05 10.76 44 831145 153 63667390
Discomfort 83.46 10.76 1486 829703 79392 63588151
Ventricular fibrillation 83.41 10.76 111 831078 23749 63643794
Hypothermia 82.89 10.76 80 831109 19776 63647767
Pneumonia cytomegaloviral 82.88 10.76 177 831012 4162 63663381
Mycobacterium chelonae infection 82.70 10.76 119 831070 2018 63665525
Rheumatoid factor positive 82.50 10.76 749 830440 34189 63633354
Palpitations 82.44 10.76 904 830285 103584 63563959
Renal failure 82.42 10.76 1749 829440 179939 63487604
Legionella infection 82.25 10.76 71 831118 655 63666888
Influenza 81.85 10.76 1873 829316 104658 63562885
Atrial fibrillation 81.74 10.76 1633 829556 169456 63498087
Epstein-Barr virus associated lymphoproliferative disorder 81.24 10.76 145 831044 2974 63664569
Torsade de pointes 80.92 10.76 63 831126 17300 63650243
Myoclonus 80.74 10.76 124 831065 24994 63642549
Liver disorder 80.50 10.76 383 830806 52968 63614575
Psoriatic arthropathy 80.47 10.76 883 830306 42398 63625145
Impaired healing 80.41 10.76 1159 830030 59314 63608229
Obliterative bronchiolitis 80.07 10.76 132 831057 2533 63665010
Rhodococcus infection 79.70 10.76 46 831143 203 63667340
Withdrawal syndrome 79.39 10.76 112 831077 23380 63644163
Pulmonary mass 79.25 10.76 556 830633 23460 63644083
Foot deformity 79.18 10.76 421 830768 16083 63651460
Product administration error 78.26 10.76 148 831041 27495 63640048
Amnesia 77.92 10.76 338 830851 47931 63619612
Fungal infection 77.71 10.76 728 830461 33523 63634020
Psychotic disorder 77.65 10.76 210 830979 34368 63633175
Delayed graft function 77.62 10.76 140 831049 2896 63664647
Liver transplant rejection 77.57 10.76 139 831050 2860 63664683
Muscle spasms 77.37 10.76 1314 829875 139709 63527834
Philadelphia positive chronic myeloid leukaemia 77.34 10.76 37 831152 100 63667443
Cerebral aspergillosis 77.13 10.76 102 831087 1591 63665952
Akathisia 77.06 10.76 26 831163 11484 63656059
Hallucination, auditory 77.02 10.76 63 831126 16876 63650667
Cytomegalovirus gastrointestinal infection 76.12 10.76 56 831133 400 63667143
Coccidioidomycosis 75.25 10.76 82 831107 1032 63666511
Limb deformity 74.73 10.76 146 831043 3215 63664328
Delusion 74.71 10.76 73 831116 17941 63649602
Malacoplakia 74.58 10.76 44 831145 204 63667339
Hallucination, visual 74.51 10.76 154 831035 27680 63639863
Anaphylactic shock 74.45 10.76 176 831013 30152 63637391
Visceral leishmaniasis 73.88 10.76 76 831113 891 63666652
Defaecation urgency 73.08 10.76 160 831029 3829 63663714
Blood pressure diastolic abnormal 72.98 10.76 326 830863 11591 63655952
Panniculitis 72.83 10.76 266 830923 8613 63658930
Product quality issue 72.30 10.76 174 831015 29625 63637918
Osteonecrosis 72.26 10.76 616 830573 27613 63639930
Heart transplant rejection 72.13 10.76 86 831103 1201 63666342
Nightmare 72.03 10.76 99 831090 20894 63646649
Renal tubular atrophy 71.02 10.76 93 831096 1436 63666107
Device dislocation 70.55 10.76 102 831087 21076 63646467
Human ehrlichiosis 70.48 10.76 50 831139 335 63667208
Toxic epidermal necrolysis 70.43 10.76 244 830945 36922 63630621
Salivary hypersecretion 70.29 10.76 34 831155 12079 63655464
Creatinine renal clearance decreased 70.21 10.76 50 831139 14371 63653172
Pulmonary oedema 70.18 10.76 661 830528 78013 63589530
Transplant dysfunction 70.10 10.76 218 830971 6490 63661053
Device difficult to use 69.42 10.76 20 831169 9778 63657765
Mucous stools 68.95 10.76 139 831050 3134 63664409
Myocardial ischaemia 68.93 10.76 121 831068 23130 63644413
Poor venous access 68.89 10.76 330 830859 12087 63655456
Skin ulcer 68.84 10.76 868 830321 43106 63624437
Oropharyngeal pain 68.75 10.76 1564 829625 87303 63580240
Graft versus host disease in lung 68.43 10.76 67 831122 737 63666806
Hypersensitivity 68.29 10.76 3141 828048 193311 63474232
Sleep disorder due to general medical condition, insomnia type 67.64 10.76 574 830615 25696 63641847
Scedosporium infection 67.35 10.76 82 831107 1172 63666371
Adenovirus infection 66.98 10.76 226 830963 7029 63660514
Alopecia 66.95 10.76 2691 828498 162999 63504544
Abdominal discomfort 66.63 10.76 2930 828259 179392 63488151
Asthma-chronic obstructive pulmonary disease overlap syndrome 66.08 10.76 77 831112 1048 63666495
Heart rate decreased 65.69 10.76 1036 830153 54031 63613512
Impaired work ability 64.21 10.76 375 830814 14844 63652699
Disability 63.61 10.76 318 830871 11854 63655689
Uveitis 63.60 10.76 328 830861 12380 63655163
Kidney fibrosis 63.32 10.76 130 831059 2971 63664572
Transient ischaemic attack 63.31 10.76 323 830866 43859 63623684
Generalised tonic-clonic seizure 63.18 10.76 281 830908 39576 63627967
Lymphadenopathy 62.95 10.76 897 830292 45789 63621754
Renal graft infection 62.89 10.76 48 831141 365 63667178
Folliculitis 62.69 10.76 628 830561 29449 63638094
Blood test abnormal 62.66 10.76 331 830858 12612 63654931
Drug level decreased 62.59 10.76 304 830885 11199 63656344
Listeriosis 62.48 10.76 100 831089 1870 63665673
Accidental exposure to product 62.35 10.76 156 831033 26208 63641335
COVID-19 pneumonia 62.24 10.76 395 830794 16109 63651434
Osteoporotic fracture 62.19 10.76 141 831048 3457 63664086
Immunosuppression 62.11 10.76 289 830900 10457 63657086
Pulmonary function test decreased 62.08 10.76 204 830985 6257 63661286
Blood urea increased 61.46 10.76 326 830863 43827 63623716
Swollen tongue 61.28 10.76 237 830952 34717 63632826
Irritable bowel syndrome 61.24 10.76 744 830445 36625 63630918
Erectile dysfunction 61.19 10.76 44 831145 12583 63654960
Cerebral toxoplasmosis 61.11 10.76 95 831094 1731 63665812
Hepatic enzyme increased 61.02 10.76 2146 829043 127797 63539746
Upper gastrointestinal haemorrhage 60.98 10.76 240 830949 34980 63632563
Escherichia infection 60.95 10.76 369 830820 14799 63652744
Sarcoidosis 60.81 10.76 196 830993 5950 63661593
Drug specific antibody 60.58 10.76 102 831087 1993 63665550
Blood pressure diastolic increased 60.56 10.76 287 830902 10465 63657078
Human polyomavirus infection 60.28 10.76 70 831119 949 63666594
Muscle injury 59.52 10.76 561 830628 25876 63641667
Atrioventricular block first degree 59.49 10.76 32 831157 10702 63656841
Sudden death 59.20 10.76 105 831084 19991 63647552
Herpes simplex 59.17 10.76 281 830908 10255 63657288
Helicobacter infection 59.11 10.76 755 830434 37607 63629936
Sexual dysfunction 59.05 10.76 7 831182 6464 63661079
Cryptosporidiosis infection 58.99 10.76 56 831133 591 63666952
Blood sodium decreased 58.99 10.76 189 831000 29293 63638250
Joint effusion 58.81 10.76 335 830854 13138 63654405
Skin lesion 58.77 10.76 724 830465 35758 63631785
Adrenal insufficiency 58.24 10.76 492 830697 21995 63645548
Musculoskeletal pain 58.06 10.76 1415 829774 79879 63587664
Bronchial wall thickening 58.03 10.76 95 831094 1812 63665731
Ulcer 57.96 10.76 500 830689 22490 63645053
Product monitoring error 57.83 10.76 3 831186 5451 63662092
Anxiety 57.67 10.76 2083 829106 200566 63466977
Myalgia 57.58 10.76 1579 829610 157038 63510505
Maternal exposure during pregnancy 57.50 10.76 1631 829558 94253 63573290
Lupus nephritis 57.22 10.76 108 831081 2316 63665227
Renal impairment 57.11 10.76 1314 829875 133703 63533840
Bone density decreased 57.04 10.76 267 830922 9685 63657858
Central nervous system lymphoma 57.01 10.76 95 831094 1840 63665703
Chest pain 56.69 10.76 2474 828715 233506 63434037
Polyarthritis 56.69 10.76 262 830927 9453 63658090
Toxoplasmosis 56.59 10.76 108 831081 2336 63665207
Dysphagia 56.40 10.76 1002 830187 105810 63561733
Vasculitis 56.28 10.76 413 830776 17682 63649861
Shock 56.25 10.76 277 830912 37963 63629580
Angina pectoris 56.20 10.76 345 830844 44736 63622807
Duodenal ulcer perforation 56.15 10.76 688 830501 33937 63633606
Tuberculosis 56.14 10.76 323 830866 12715 63654828
Acanthamoeba infection 56.02 10.76 48 831141 438 63667105
Hypernatraemia 55.83 10.76 45 831144 12144 63655399
Thrombocytopenia 55.71 10.76 2337 828852 221464 63446079
Breath sounds abnormal 55.52 10.76 297 830892 11372 63656171
Biopsy lung abnormal 55.45 10.76 31 831158 127 63667416
Eosinophil count abnormal 55.43 10.76 52 831137 540 63667003
Aphasia 55.29 10.76 305 830884 40601 63626942
Memory impairment 55.25 10.76 774 830415 84908 63582635
Bradyphrenia 55.19 10.76 26 831163 9380 63658163
Blood pressure diastolic decreased 55.18 10.76 483 830706 21818 63645725
Ataxia 55.14 10.76 127 831062 21957 63645586
Impaired quality of life 54.90 10.76 196 830993 6275 63661268
Encephalitis viral 54.89 10.76 105 831084 2275 63665268
Coma scale abnormal 54.84 10.76 16 831173 7758 63659785
Status epilepticus 54.55 10.76 124 831065 21539 63646004
Ketoacidosis 54.52 10.76 11 831178 6852 63660691
Inappropriate antidiuretic hormone secretion 54.19 10.76 130 831059 22159 63645384
Mass 54.18 10.76 360 830829 14916 63652627
Neutropenia 53.95 10.76 2530 828659 237094 63430449
Wrist deformity 53.87 10.76 89 831100 1711 63665832
Bronchial obstruction 53.85 10.76 104 831085 2270 63665273
Cytomegalovirus chorioretinitis 53.54 10.76 162 831027 4750 63662793
Cyanosis 53.25 10.76 130 831059 22025 63645518
Unintentional medical device removal 53.06 10.76 11 831178 6723 63660820
Exposure to toxic agent 53.02 10.76 8 831181 6151 63661392
Hepatosplenic T-cell lymphoma 52.92 10.76 59 831130 763 63666780
Blood pressure decreased 52.67 10.76 787 830402 85412 63582131
Fistula 52.42 10.76 257 830932 9504 63658039
Hypocalcaemia 52.33 10.76 319 830870 41434 63626109
Ventricular extrasystoles 52.17 10.76 91 831098 17438 63650105
Electrocardiogram abnormal 52.11 10.76 58 831131 13423 63654120
Babesiosis 51.91 10.76 37 831152 250 63667293
Periostitis 51.89 10.76 48 831141 489 63667054
Metastases to liver 51.82 10.76 148 831041 23793 63643750
Gastroenteritis norovirus 51.63 10.76 112 831077 2663 63664880
Mycotic allergy 51.56 10.76 64 831125 934 63666609
Granuloma skin 51.55 10.76 184 831005 5890 63661653
Jaundice 51.17 10.76 390 830799 48122 63619421
Granulocytopenia 51.09 10.76 36 831153 10404 63657139
Hypogammaglobulinaemia 50.97 10.76 265 830924 10034 63657509
Coronavirus infection 50.82 10.76 172 831017 5358 63662185
Musculoskeletal disorder 50.82 10.76 400 830789 17506 63650037
Antipsychotic drug level increased 50.71 10.76 4 831185 5111 63662432
Dementia 50.58 10.76 121 831068 20645 63646898
Liver function test abnormal 50.47 10.76 505 830684 58896 63608647
Night sweats 50.38 10.76 697 830492 35349 63632194
Ear pain 50.07 10.76 520 830669 24616 63642927
Mucocutaneous leishmaniasis 49.96 10.76 43 831146 395 63667148
Sinus pain 49.90 10.76 106 831083 2483 63665060
Paraesthesia 49.90 10.76 1335 829854 133187 63534356
Blood glucose increased 49.89 10.76 926 830263 97147 63570396
Skin necrosis 49.81 10.76 336 830853 13993 63653550
Neuropathy peripheral 49.64 10.76 1144 830045 116381 63551162
Bronchial disorder 49.63 10.76 94 831095 2021 63665522
Bronchopulmonary aspergillosis allergic 49.63 10.76 81 831108 1541 63666002
Atrioventricular block complete 49.46 10.76 68 831121 14350 63653193
Fungal skin infection 49.41 10.76 162 831027 4963 63662580
Blood parathyroid hormone decreased 49.32 10.76 207 830982 7159 63660384
Body height below normal 49.27 10.76 86 831103 1732 63665811
Arthritis bacterial 49.18 10.76 216 830973 7623 63659920
Euglycaemic diabetic ketoacidosis 49.00 10.76 6 831183 5404 63662139
Depressed mood 48.99 10.76 318 830871 40694 63626849
Blood creatinine increased 48.94 10.76 1353 829836 134429 63533114
Klebsiella infection 48.93 10.76 316 830873 12965 63654578
Polymyalgia rheumatica 48.74 10.76 123 831066 3236 63664307
Granuloma 48.73 10.76 192 830997 6449 63661094
Secretion discharge 48.67 10.76 292 830897 11672 63655871
Exposure via ingestion 48.14 10.76 4 831185 4898 63662645
Restless legs syndrome 48.13 10.76 92 831097 17024 63650519
Bronchitis 48.13 10.76 1784 829405 106959 63560584
Heart rate irregular 48.11 10.76 553 830636 26860 63640683
Blood pressure systolic abnormal 47.96 10.76 254 830935 9688 63657855
Sporotrichosis 47.86 10.76 23 831166 63 63667480
Presyncope 47.77 10.76 261 830928 34828 63632715
Total lung capacity increased 47.62 10.76 52 831137 656 63666887
Contrast media allergy 47.60 10.76 93 831096 2048 63665495
Toxic skin eruption 47.26 10.76 112 831077 19172 63648371
Fear 47.20 10.76 120 831069 20051 63647492
Erythema multiforme 47.19 10.76 81 831108 15620 63651923
Knee arthroplasty 47.09 10.76 544 830645 26455 63641088
Middle insomnia 46.60 10.76 305 830884 12572 63654971
Human antichimeric antibody positive 46.46 10.76 73 831116 1343 63666200
Ischaemic stroke 46.44 10.76 204 830985 28831 63638712
Colectomy 46.39 10.76 104 831085 2530 63665013
Device adhesion issue 46.37 10.76 6 831183 5180 63662363
Haemoglobin decreased 46.02 10.76 2049 829140 193014 63474529
Product dose omission issue 45.88 10.76 2046 829143 192701 63474842
Rhinorrhoea 45.62 10.76 1053 830136 58916 63608627
Angina unstable 45.39 10.76 81 831108 15386 63652157
Cardiogenic shock 45.36 10.76 239 830950 32188 63635355
Myopathy 45.35 10.76 386 830803 17294 63650249
Vaginal haemorrhage 45.32 10.76 115 831074 19229 63648314
Upper respiratory fungal infection 45.26 10.76 35 831154 272 63667271
Coordination abnormal 45.16 10.76 77 831112 14887 63652656
Mental impairment 44.96 10.76 89 831100 16254 63651289
Therapy non-responder 44.96 10.76 1140 830049 64759 63602784
Prothrombin time prolonged 44.80 10.76 84 831105 15657 63651886
Pneumocystis jirovecii infection 44.74 10.76 96 831093 2265 63665278
Incorrect product administration duration 44.73 10.76 36 831153 9722 63657821
Pulmonary nocardiosis 44.66 10.76 52 831137 707 63666836
Hypertonia 44.65 10.76 13 831176 6312 63661231
Hepatic failure 44.58 10.76 477 830712 54917 63612626
Abnormal dreams 44.07 10.76 41 831148 10315 63657228
Cytomegalovirus syndrome 43.99 10.76 34 831155 264 63667279
Necrotising retinitis 43.81 10.76 61 831128 1002 63666541
Electrocardiogram QRS complex prolonged 43.77 10.76 33 831156 9211 63658332
Body temperature decreased 43.70 10.76 519 830670 25409 63642134
Device occlusion 43.68 10.76 38 831151 9875 63657668
Respiratory symptom 43.48 10.76 111 831078 2942 63664601
Eosinophilic granulomatosis with polyangiitis 43.36 10.76 107 831082 2775 63664768
Hypoglycaemic coma 43.35 10.76 3 831186 4271 63663272
Sensitisation 43.21 10.76 79 831110 1652 63665891
Body temperature fluctuation 42.98 10.76 116 831073 3182 63664361
Orf 42.88 10.76 20 831169 50 63667493
Hepatitis E 42.84 10.76 96 831093 2335 63665208
Aphthous ulcer 42.70 10.76 299 830890 12607 63654936
Oral herpes 42.59 10.76 455 830734 21697 63645846
Enterovirus infection 42.21 10.76 71 831118 1386 63666157
Complications of transplanted lung 42.10 10.76 38 831151 374 63667169
Complication of device insertion 42.04 10.76 7 831182 5005 63662538
Drug screen positive 41.89 10.76 11 831178 5718 63661825
Flushing 41.76 10.76 737 830452 77911 63589632
Epidural lipomatosis 41.76 10.76 54 831135 823 63666720
Asphyxia 41.75 10.76 37 831152 9529 63658014
Spirometry abnormal 41.73 10.76 44 831145 532 63667011
Metastases to central nervous system 41.60 10.76 72 831117 13840 63653703
Scleritis 41.37 10.76 107 831082 2859 63664684
Disseminated blastomycosis 41.18 10.76 23 831166 94 63667449
Head injury 41.11 10.76 251 830938 32591 63634952
Prostatic specific antigen increased 41.03 10.76 222 830967 8538 63659005
Nodule 40.98 10.76 382 830807 17565 63649978
Hip arthroplasty 40.79 10.76 438 830751 20913 63646630
Joint injury 40.76 10.76 464 830725 22483 63645060
Chronic sinusitis 40.72 10.76 175 831014 6117 63661426
Rash maculo-papular 40.70 10.76 398 830791 46628 63620915
Dry mouth 40.67 10.76 541 830648 59877 63607666
Epstein-Barr virus associated lymphoma 40.65 10.76 55 831134 878 63666665
Cardiac failure chronic 40.64 10.76 34 831155 9007 63658536
Viraemia 40.54 10.76 92 831097 2257 63665286
Viral infection 40.51 10.76 673 830516 35467 63632076
Rheumatoid lung 40.48 10.76 95 831094 2384 63665159
Disseminated tuberculosis 40.47 10.76 121 831068 3524 63664019
Vision blurred 40.46 10.76 871 830318 89445 63578098
Irritability 40.38 10.76 292 830897 36454 63631089
Meningitis listeria 40.37 10.76 50 831139 728 63666815
Eye infection toxoplasmal 40.36 10.76 40 831149 447 63667096
Full blood count decreased 40.30 10.76 152 831037 22430 63645113
Kaposi's sarcoma 40.26 10.76 49 831140 700 63666843
Pulmonary fibrosis 40.25 10.76 574 830615 29304 63638239
Rhinitis 40.19 10.76 257 830932 10508 63657035
Apnoea 40.11 10.76 45 831144 10377 63657166
Glycosylated haemoglobin increased 40.09 10.76 92 831097 15927 63651616
Mycobacterium abscessus infection 40.03 10.76 57 831132 957 63666586
Synovial cyst 40.02 10.76 201 830988 7506 63660037
Electrolyte imbalance 39.99 10.76 178 831011 25065 63642478
Lupus-like syndrome 39.97 10.76 221 830968 8570 63658973
Mental status changes 39.96 10.76 551 830638 60611 63606932
Pulmonary function test abnormal 39.95 10.76 110 831079 3054 63664489
Granulomatosis with polyangiitis 39.94 10.76 86 831103 2034 63665509
Second primary malignancy 39.76 10.76 284 830905 12053 63655490
Jaundice cholestatic 39.72 10.76 32 831157 8638 63658905
Faecaloma 39.68 10.76 40 831149 9688 63657855
Bradypnoea 39.49 10.76 9 831180 5150 63662393
Device use error 39.36 10.76 17 831172 6454 63661089
Immunosuppressant drug level decreased 39.34 10.76 78 831111 1737 63665806
Chronic kidney disease 39.21 10.76 518 830671 57401 63610142
Steroid withdrawal syndrome 39.03 10.76 45 831144 605 63666938
Sinus tachycardia 38.74 10.76 249 830940 31939 63635604
Cat scratch disease 38.71 10.76 30 831159 234 63667309
Psychomotor hyperactivity 38.64 10.76 80 831109 14371 63653172
Peak expiratory flow rate decreased 38.59 10.76 44 831145 584 63666959
Urinary incontinence 38.42 10.76 290 830899 35861 63631682
Microsporidia infection 38.42 10.76 49 831140 736 63666807
Clonus 38.42 10.76 15 831174 6052 63661491
Ammonia increased 38.37 10.76 21 831168 6956 63660587
Mood altered 38.21 10.76 94 831095 15885 63651658
Hepatic encephalopathy 38.12 10.76 141 831048 20925 63646618
Hyperprolactinaemia 38.10 10.76 4 831185 4061 63663482
Joint range of motion decreased 37.98 10.76 399 830790 18944 63648599
Speech disorder 37.83 10.76 420 830769 48021 63619522
Pseudohyponatraemia 37.81 10.76 23 831166 114 63667429
Cutaneous blastomycosis 37.66 10.76 16 831173 29 63667514
Atrioventricular block second degree 37.63 10.76 18 831171 6436 63661107
Upper-airway cough syndrome 37.58 10.76 217 830972 8553 63658990
Skin plaque 37.53 10.76 220 830969 8720 63658823
Loose body in joint 37.50 10.76 61 831128 1157 63666386
Lower respiratory tract congestion 37.44 10.76 103 831086 2858 63664685
Complication associated with device 37.42 10.76 87 831102 14993 63652550
Upper respiratory tract inflammation 37.38 10.76 3 831186 3779 63663764
Lung disorder 37.36 10.76 1036 830153 59664 63607879
Haematoma 37.32 10.76 398 830791 45852 63621691
Enterococcal infection 37.31 10.76 306 830883 13560 63653983
Eosinophilic bronchitis 37.17 10.76 34 831155 341 63667202
Wrong patient received product 37.13 10.76 3 831186 3759 63663784
Necrotising herpetic retinopathy 37.13 10.76 22 831167 103 63667440
Osteopenia 37.12 10.76 334 830855 15206 63652337
Scleroderma renal crisis 37.05 10.76 35 831154 367 63667176
Atrioventricular block 37.02 10.76 61 831128 11954 63655589
Fibromyalgia 37.02 10.76 657 830532 35074 63632469
Calciphylaxis 36.82 10.76 110 831079 3202 63664341
Haematochezia 36.78 10.76 1118 830071 65255 63602288
Dermatophytosis 36.75 10.76 35 831154 371 63667172
Personality change 36.59 10.76 34 831155 8559 63658984
Respiratory failure 36.33 10.76 2477 828712 158706 63508837
Colitis 36.27 10.76 1002 830187 57672 63609871
Paranoia 36.20 10.76 100 831089 16252 63651291
B-cell lymphoma recurrent 36.18 10.76 49 831140 783 63666760
Pneumonia pseudomonal 36.18 10.76 142 831047 4761 63662782
Treatment noncompliance 35.97 10.76 372 830817 43110 63624433
Nasal oedema 35.93 10.76 54 831135 954 63666589
Uterine perforation 35.86 10.76 15 831174 5805 63661738
Lymph node calcification 35.74 10.76 31 831158 288 63667255
Myelodysplastic syndrome 35.64 10.76 526 830663 27053 63640490
Acute respiratory distress syndrome 35.53 10.76 702 830487 38233 63629310
Osteomyelitis fungal 35.50 10.76 29 831160 246 63667297
Obstruction 35.29 10.76 107 831082 3141 63664402
Drug tolerance decreased 35.28 10.76 181 831008 6817 63660726
Necrotising oesophagitis 35.25 10.76 44 831145 646 63666897
Encephalopathy 35.25 10.76 539 830650 58280 63609263
Disseminated varicella zoster virus infection 35.23 10.76 29 831160 249 63667294
Ankle deformity 35.14 10.76 43 831146 618 63666925
Skin exfoliation 35.12 10.76 389 830800 44496 63623047
Medial tibial stress syndrome 34.97 10.76 22 831167 117 63667426
Fluid retention 34.77 10.76 549 830640 59057 63608486
Oesophageal candidiasis 34.77 10.76 199 830990 7818 63659725
Pericarditis fungal 34.76 10.76 24 831165 153 63667390
Bacterial infection 34.69 10.76 482 830707 24468 63643075
Lymphoproliferative disorder 34.63 10.76 144 831045 4959 63662584
Abdominal abscess 34.58 10.76 167 831022 6137 63661406
Sensory disturbance 34.58 10.76 74 831115 13134 63654409
Bone disorder 34.48 10.76 349 830840 16410 63651133
Tooth infection 34.46 10.76 313 830876 14288 63653255
Salmonellosis 34.39 10.76 62 831127 1282 63666261
Application site erythema 34.29 10.76 9 831180 4680 63662863
Finger deformity 34.15 10.76 145 831044 5041 63662502
Multiple sclerosis 34.12 10.76 127 831062 18814 63648729
Anal fissure 34.06 10.76 140 831049 4796 63662747
Pneumoperitoneum 33.98 10.76 94 831095 2617 63664926
Pre-engraftment immune reaction 33.96 10.76 31 831158 310 63667233
Haematuria 33.94 10.76 561 830628 59910 63607633
Skin mass 33.90 10.76 181 831008 6925 63660618
Plasma cell myeloma 33.84 10.76 405 830784 45670 63621873
Bone swelling 33.54 10.76 58 831131 1159 63666384
Vital capacity decreased 33.43 10.76 54 831135 1018 63666525
Acute generalised exanthematous pustulosis 33.38 10.76 83 831106 13975 63653568
Escherichia bacteraemia 33.23 10.76 148 831041 5255 63662288
Blood glucose decreased 33.15 10.76 169 831020 22954 63644589
Mycobacterium fortuitum infection 33.08 10.76 25 831164 187 63667356
Opportunistic infection 33.07 10.76 92 831097 2570 63664973
Bronchial secretion retention 33.05 10.76 89 831100 2438 63665105
Hyperthermia 33.02 10.76 97 831092 15453 63652090
Lymphopenia 33.02 10.76 489 830700 25168 63642375
Bronchial polyp 32.90 10.76 18 831171 70 63667473
Blood potassium decreased 32.86 10.76 347 830842 40052 63627491
Social avoidant behaviour 32.85 10.76 9 831180 4548 63662995
Seasonal allergy 32.76 10.76 261 830928 11465 63656078
Symptom masked 32.69 10.76 57 831132 1147 63666396
Allergy to animal 32.62 10.76 52 831137 969 63666574
Joint destruction 32.46 10.76 112 831077 3524 63664019
Drug specific antibody present 32.32 10.76 142 831047 5012 63662531
Hypothyroidism 32.30 10.76 349 830840 40108 63627435
Acute pulmonary histoplasmosis 32.26 10.76 26 831163 216 63667327
Oxalosis 32.22 10.76 19 831170 88 63667455
Breast cancer metastatic 32.18 10.76 27 831162 7142 63660401
Epstein-Barr virus test positive 32.12 10.76 51 831138 947 63666596
Human herpesvirus 6 infection 32.11 10.76 132 831057 4522 63663021
Respiratory tract inflammation 32.06 10.76 45 831144 745 63666798
Obsessive-compulsive disorder 32.05 10.76 11 831178 4807 63662736
Infection parasitic 31.99 10.76 32 831157 362 63667181
End stage renal disease 31.96 10.76 238 830951 10237 63657306
Emphysema 31.89 10.76 299 830890 13770 63653773
Kidney infection 31.82 10.76 361 830828 17477 63650066
Immune system disorder 31.56 10.76 214 830975 8927 63658616
Abscess 31.48 10.76 384 830805 18920 63648623
Staphylococcal infection 31.48 10.76 866 830323 49812 63617731
Histoplasmosis cutaneous 31.46 10.76 14 831175 30 63667513
Dialysis 31.44 10.76 112 831077 16808 63650735
Chorioretinopathy 31.41 10.76 80 831109 2117 63665426
Lymphocele 31.41 10.76 67 831122 1574 63665969
Acute myeloid leukaemia 31.37 10.76 513 830676 26950 63640593
Pancreatitis acute 31.35 10.76 377 830812 42478 63625065
Hiccups 31.33 10.76 37 831152 8339 63659204
Right ventricular failure 31.31 10.76 156 831033 21315 63646228
Cryptococcal fungaemia 31.29 10.76 22 831167 145 63667398
Interstitial lung disease 31.25 10.76 1550 829639 96182 63571361
Lip swelling 31.11 10.76 262 830927 31645 63635898
Hepatic cytolysis 31.03 10.76 86 831103 13963 63653580
Petit mal epilepsy 30.96 10.76 13 831176 5019 63662524
Temperature regulation disorder 30.95 10.76 8 831181 4203 63663340
Remission not achieved 30.92 10.76 30 831159 326 63667217
Neoplasm progression 30.88 10.76 358 830831 40606 63626937
Basal cell carcinoma 30.88 10.76 564 830625 30274 63637269
Dermatitis acneiform 30.83 10.76 38 831151 8405 63659138
Tumour marker increased 30.83 10.76 4 831185 3446 63664097
Pallor 30.78 10.76 335 830854 38446 63629097
Herpes zoster cutaneous disseminated 30.76 10.76 31 831158 354 63667189
Galactorrhoea 30.60 10.76 3 831186 3216 63664327
Subdural haemorrhage 30.59 10.76 15 831174 5288 63662255
Multifocal micronodular pneumocyte hyperplasia 30.53 10.76 17 831172 69 63667474
Polyp 30.51 10.76 168 831021 6505 63661038
Herpes simplex hepatitis 30.48 10.76 33 831156 412 63667131
Long QT syndrome 30.47 10.76 14 831175 5125 63662418
Acarodermatitis 30.47 10.76 56 831133 1176 63666367
Vascular hyalinosis 30.45 10.76 13 831176 24 63667519
Emphysematous pyelonephritis 30.43 10.76 25 831164 214 63667329
Arthrodesis 30.32 10.76 76 831113 1991 63665552
Bloody discharge 30.25 10.76 62 831127 1415 63666128
Diffuse large B-cell lymphoma refractory 30.24 10.76 53 831136 1071 63666472
Wrist surgery 30.11 10.76 42 831147 691 63666852
New onset diabetes after transplantation 29.92 10.76 20 831169 120 63667423
Weight fluctuation 29.87 10.76 196 830993 8086 63659457
Chronic obstructive pulmonary disease 29.85 10.76 1159 830030 69889 63597654
Drug abuser 29.80 10.76 19 831170 5789 63661754
Nephropathy toxic 29.70 10.76 351 830838 17163 63650380
Cholecystitis chronic 29.70 10.76 46 831143 9241 63658302
Accidental death 29.53 10.76 6 831183 3719 63663824
Faeces discoloured 29.47 10.76 202 830987 25527 63642016
Endocarditis bacterial 29.45 10.76 58 831131 1285 63666258
Hypophagia 29.44 10.76 347 830842 39240 63628303
Lung abscess 29.39 10.76 107 831082 3459 63664084
Device leakage 29.36 10.76 38 831151 8228 63659315
Central nervous system vasculitis 29.23 10.76 53 831136 1101 63666442
Body temperature increased 29.19 10.76 648 830541 36018 63631525
Prescribed underdose 29.16 10.76 126 831063 17889 63649654
Bladder cancer 29.13 10.76 61 831128 10913 63656630
Deformity 29.10 10.76 159 831030 6138 63661405
Anaphylactic reaction 29.09 10.76 668 830521 67996 63599547
Amylase increased 29.08 10.76 50 831139 9635 63657908
Heparin-induced thrombocytopenia 29.07 10.76 40 831149 8439 63659104
Disability assessment scale score increased 29.05 10.76 85 831104 2445 63665098
Neuroendocrine carcinoma of the skin 29.05 10.76 49 831140 959 63666584
Psychomotor retardation 28.99 10.76 15 831174 5128 63662415
Somnambulism 28.97 10.76 15 831174 5126 63662417
Eye abscess 28.89 10.76 27 831162 279 63667264
Enterobacter infection 28.87 10.76 109 831080 3587 63663956
Vertigo 28.83 10.76 561 830628 58450 63609093
Blood potassium increased 28.77 10.76 206 830983 25774 63641769
Epstein Barr virus positive mucocutaneous ulcer 28.73 10.76 40 831149 657 63666886
Drug effective for unapproved indication 28.67 10.76 109 831080 3599 63663944
Rhonchi 28.62 10.76 104 831085 3359 63664184
Human bocavirus infection 28.52 10.76 36 831153 535 63667008
Pyomyositis 28.50 10.76 35 831154 505 63667038
Hypotonia 28.38 10.76 64 831125 11148 63656395
Ileostomy 28.23 10.76 54 831135 1170 63666373
Cytomegalovirus nephritis 28.19 10.76 20 831169 134 63667409
Face oedema 28.07 10.76 195 830994 24566 63642977
Thirst 28.02 10.76 91 831098 14046 63653497
Ventricular remodelling 28.00 10.76 18 831171 100 63667443
Nystagmus 27.98 10.76 46 831143 9022 63658521
Pulse absent 27.96 10.76 45 831144 8901 63658642
T-cell lymphoma 27.87 10.76 53 831136 1143 63666400
Diabetic neuropathy 27.82 10.76 19 831170 5582 63661961
Tuberculin test positive 27.82 10.76 95 831094 2973 63664570
Cerebral haematoma 27.67 10.76 31 831158 7154 63660389
Choroiditis 27.63 10.76 50 831139 1037 63666506
Thinking abnormal 27.62 10.76 68 831121 11488 63656055
Systemic mycosis 27.60 10.76 79 831110 2244 63665299
Alcohol abuse 27.58 10.76 14 831175 4838 63662705
Encephalitis 27.42 10.76 265 830924 12306 63655237
Primary effusion lymphoma 27.21 10.76 13 831176 35 63667508
Squamous cell carcinoma 27.19 10.76 286 830903 13583 63653960
Femoral neck fracture 27.15 10.76 44 831145 8680 63658863
Chorioretinitis 27.08 10.76 38 831151 629 63666914
Systemic lupus erythematosus rash 27.07 10.76 58 831131 1367 63666176
Coronary artery stenosis 27.03 10.76 66 831123 11182 63656361
Ureaplasma infection 26.97 10.76 40 831149 698 63666845
Cholestasis 26.95 10.76 411 830778 44461 63623082
Sputum purulent 26.95 10.76 53 831136 1173 63666370
Animal scratch 26.94 10.76 47 831142 946 63666597
Disseminated coccidioidomycosis 26.89 10.76 14 831175 48 63667495
Haematocrit decreased 26.88 10.76 519 830670 54136 63613407
B-cell lymphoma 26.72 10.76 140 831049 5317 63662226
Pneumonia fungal 26.69 10.76 201 830988 8676 63658867
Donor specific antibody present 26.66 10.76 23 831166 212 63667331
Hepatocellular injury 26.60 10.76 416 830773 44819 63622724
Thrombotic microangiopathy 26.60 10.76 330 830859 16325 63651218
Serum sickness 26.55 10.76 96 831093 3093 63664450
Solar lentigo 26.48 10.76 44 831145 850 63666693
Infective tenosynovitis 26.48 10.76 26 831163 287 63667256
Drooling 26.48 10.76 18 831171 5301 63662242
Polyomavirus viraemia 26.47 10.76 51 831138 1111 63666432
Loss of therapeutic response 26.47 10.76 25 831164 262 63667281
Fear of injection 26.47 10.76 148 831041 5764 63661779
Pleural thickening 26.43 10.76 86 831103 2624 63664919
Immunodeficiency 26.41 10.76 321 830868 15803 63651740
Hypertensive crisis 26.37 10.76 133 831056 18115 63649428
Device issue 26.35 10.76 177 831012 22471 63645072
Abortion incomplete 26.29 10.76 4 831185 3057 63664486
Mite allergy 26.15 10.76 39 831150 684 63666859
Mycobacterium marinum infection 26.07 10.76 29 831160 374 63667169
Limb mass 26.05 10.76 92 831097 2929 63664614
Anhedonia 25.95 10.76 90 831099 13616 63653927
Malignant transformation 25.90 10.76 50 831139 1091 63666452
Activated partial thromboplastin time prolonged 25.85 10.76 82 831107 12749 63654794
Lymphadenitis 25.84 10.76 107 831082 3678 63663865
Red blood cell count decreased 25.82 10.76 453 830736 47933 63619610
Herpes virus infection 25.79 10.76 153 831036 6091 63661452
Genital haemorrhage 25.78 10.76 20 831169 5502 63662041
Gastritis 25.72 10.76 390 830799 42228 63625315
Pancreatic carcinoma 25.62 10.76 60 831129 10313 63657230
Pulmonary hypertension 25.61 10.76 396 830793 42743 63624800
Pain in extremity 25.56 10.76 4360 826829 298725 63368818
Disseminated aspergillosis 25.56 10.76 37 831152 631 63666912
Cutaneous calcification 25.56 10.76 17 831172 101 63667442
Complications of transplant surgery 25.51 10.76 39 831150 700 63666843
Lung hyperinflation 25.48 10.76 61 831128 1551 63665992
Elbow deformity 25.44 10.76 53 831136 1224 63666319
Blood prolactin increased 25.37 10.76 7 831182 3521 63664022
Eosinophil count increased 25.35 10.76 286 830903 13826 63653717
Glomerular filtration rate decreased 25.33 10.76 148 831041 19424 63648119
Photodermatosis 25.26 10.76 43 831146 848 63666695
Squamous cell carcinoma of skin 25.24 10.76 249 830940 11627 63655916
Hyperreflexia 25.24 10.76 33 831156 7115 63660428
X-ray abnormal 25.19 10.76 58 831131 1437 63666106
Respiratory tract infection 25.18 10.76 646 830543 36761 63630782
Subarachnoid haemorrhage 25.18 10.76 137 831052 18301 63649242
Right atrial hypertrophy 25.08 10.76 33 831156 512 63667031
Chest discomfort 25.05 10.76 1778 829411 114328 63553215
Tuberculosis of central nervous system 25.04 10.76 29 831160 392 63667151
Muscle twitching 24.94 10.76 143 831046 18855 63648688
Joint laxity 24.92 10.76 76 831113 2238 63665305
Wrong product administered 24.92 10.76 38 831151 7682 63659861
Cold sweat 24.89 10.76 118 831071 16337 63651206
Coronary arterial stent insertion 24.86 10.76 22 831167 5670 63661873
Priapism 24.84 10.76 10 831179 3960 63663583
Disseminated cytomegaloviral infection 24.81 10.76 29 831160 396 63667147
Bacterial sepsis 24.81 10.76 173 831016 7284 63660259
Colitis ischaemic 24.78 10.76 89 831100 13325 63654218
Reversible airways obstruction 24.78 10.76 49 831140 1089 63666454
Cerebral fungal infection 24.74 10.76 26 831163 313 63667230
Sinus congestion 24.69 10.76 306 830883 15133 63652410
Polyuria 24.63 10.76 82 831107 12561 63654982
Respiratory rate increased 24.63 10.76 352 830837 17979 63649564
Frustration tolerance decreased 24.60 10.76 149 831040 5976 63661567
Alcohol poisoning 24.60 10.76 12 831177 4243 63663300
Chronic graft versus host disease in skin 24.59 10.76 55 831134 1336 63666207
Tractional retinal detachment 24.56 10.76 15 831174 75 63667468
Pleocytosis 24.51 10.76 48 831141 1059 63666484
Heavy menstrual bleeding 24.45 10.76 77 831112 12000 63655543
Hypertrophic osteoarthropathy 24.43 10.76 17 831172 110 63667433
Asthenia 24.41 10.76 5007 826182 423037 63244506
Complications of transplanted heart 24.37 10.76 25 831164 292 63667251
Wheelchair user 24.37 10.76 122 831067 4550 63662993
Cryptococcal cutaneous infection 24.33 10.76 19 831170 150 63667393
Akinesia 24.32 10.76 5 831184 3074 63664469
Left ventricular dysfunction 24.25 10.76 124 831065 16830 63650713
Post transplant distal limb syndrome 24.25 10.76 32 831157 498 63667045
Chromaturia 24.21 10.76 181 831008 22430 63645113
Pulmonary cavitation 24.16 10.76 54 831135 1311 63666232
Pulmonary toxicity 24.16 10.76 191 830998 8370 63659173
Tenosynovitis 24.14 10.76 246 830943 11587 63655956
Renal tubular injury 24.09 10.76 49 831140 1112 63666431
Glaucoma 24.03 10.76 319 830870 16029 63651514
Cutaneous sporotrichosis 24.00 10.76 11 831178 26 63667517
Gastric cancer 23.95 10.76 29 831160 6464 63661079
Arteriosclerosis 23.93 10.76 114 831075 15763 63651780
Cerebral venous sinus thrombosis 23.93 10.76 65 831124 1790 63665753
Mycobacterium haemophilum infection 23.67 10.76 13 831176 51 63667492
Mental disorder 23.65 10.76 222 830967 26223 63641320
Colectomy total 23.64 10.76 21 831168 202 63667341
Sinus node dysfunction 23.63 10.76 32 831157 6796 63660747
Forced vital capacity decreased 23.57 10.76 57 831132 1459 63666084
Respiratory acidosis 23.55 10.76 58 831131 9797 63657746
Renal transplant 23.44 10.76 73 831116 2175 63665368
Bacterial pyelonephritis 23.37 10.76 32 831157 517 63667026
Bundle branch block right 23.33 10.76 62 831127 10207 63657336
Inflammatory bowel disease 23.32 10.76 118 831071 4420 63663123
Stress cardiomyopathy 23.30 10.76 53 831136 9204 63658339
Urticaria thermal 23.28 10.76 19 831170 161 63667382
Mouth ulceration 23.24 10.76 565 830624 31879 63635664
Blood loss anaemia 23.20 10.76 96 831093 13796 63653747
Cytokine release syndrome 23.14 10.76 165 831024 20664 63646879
Restrictive pulmonary disease 23.08 10.76 71 831118 2101 63665442
Intervertebral disc space narrowing 23.07 10.76 53 831136 1311 63666232
Mantle cell lymphoma recurrent 23.07 10.76 30 831159 460 63667083
Acute lymphocytic leukaemia recurrent 23.06 10.76 108 831081 3918 63663625
Pneumonia cryptococcal 23.04 10.76 50 831139 1189 63666354
Thyroid neoplasm 22.99 10.76 81 831108 2576 63664967
Trichophytosis 22.98 10.76 25 831164 314 63667229
Meningitis enterococcal 22.97 10.76 15 831174 86 63667457
Latent tuberculosis 22.96 10.76 83 831106 2674 63664869
Angiocentric lymphoma 22.95 10.76 39 831150 768 63666775
Large intestinal ulcer 22.95 10.76 111 831078 4082 63663461
Meningoencephalitis viral 22.92 10.76 27 831162 372 63667171
Traumatic lung injury 22.90 10.76 73 831116 2203 63665340
Coagulopathy 22.90 10.76 282 830907 31638 63635905
Ophthalmic herpes zoster 22.84 10.76 71 831118 2113 63665430
Cutaneous nocardiosis 22.82 10.76 19 831170 166 63667377
Pulmonary mucormycosis 22.77 10.76 39 831150 773 63666770
Crepitations 22.56 10.76 177 831012 7738 63659805
Stenotrophomonas infection 22.56 10.76 89 831100 2991 63664552
Dry skin 22.44 10.76 495 830694 50666 63616877
Cardiomegaly 22.41 10.76 196 830993 23488 63644055
Lipodystrophy acquired 22.33 10.76 12 831177 4015 63663528
Neutropenic sepsis 22.29 10.76 192 830997 23080 63644463
Antisynthetase syndrome 22.20 10.76 17 831172 130 63667413
Device related infection 22.18 10.76 270 830919 30356 63637187
Disseminated mycobacterium avium complex infection 22.18 10.76 15 831174 92 63667451
Gastrosplenic fistula 22.18 10.76 14 831175 75 63667468
Dysplastic naevus 22.17 10.76 30 831159 479 63667064
Rhinitis allergic 22.13 10.76 179 831010 7899 63659644
Crohn's disease 22.06 10.76 66 831123 1923 63665620
Conjunctivitis allergic 22.01 10.76 44 831145 986 63666557
Apparent mineralocorticoid excess 21.95 10.76 11 831178 34 63667509
Cutaneous leishmaniasis 21.88 10.76 23 831166 277 63667266
Hypovolaemic shock 21.83 10.76 64 831125 10202 63657341
Skin papilloma 21.82 10.76 128 831061 5075 63662468
Ileus 21.76 10.76 190 830999 22776 63644767
Episcleritis 21.75 10.76 39 831150 803 63666740
Thrombosis in device 21.67 10.76 20 831169 5051 63662492
Perfume sensitivity 21.66 10.76 34 831155 625 63666918
Disseminated sporotrichosis 21.65 10.76 9 831180 15 63667528
Blood thyroid stimulating hormone increased 21.65 10.76 41 831148 7613 63659930
Diabetic retinopathy 21.64 10.76 5 831184 2834 63664709
Ventricular arrhythmia 21.61 10.76 39 831150 7376 63660167
Dissociation 21.60 10.76 6 831183 3005 63664538
Hyperaesthesia 21.60 10.76 62 831127 9952 63657591
Rectal abscess 21.54 10.76 56 831133 1501 63666042
Pneumonia legionella 21.53 10.76 75 831114 2371 63665172
Tumour haemorrhage 21.53 10.76 9 831180 3484 63664059
Pancreas transplant rejection 21.50 10.76 23 831166 283 63667260
Lung opacity 21.50 10.76 90 831099 3109 63664434
Giant cell arteritis 21.49 10.76 72 831117 2231 63665312
Complement factor C3 decreased 21.44 10.76 23 831166 284 63667259
Device malfunction 21.43 10.76 136 831053 17497 63650046
Haemorrhage subcutaneous 21.39 10.76 15 831174 4346 63663197
Toxic anterior segment syndrome 21.38 10.76 3 831186 2436 63665107
Pancreatic carcinoma metastatic 21.37 10.76 9 831180 3469 63664074
Disseminated Bacillus Calmette-Guerin infection 21.37 10.76 19 831170 183 63667360
Intestinal perforation 21.36 10.76 296 830893 15017 63652526
Herpes oesophagitis 21.32 10.76 22 831167 259 63667284
Choriomeningitis lymphocytic 21.31 10.76 12 831177 50 63667493
Urate nephropathy 21.30 10.76 17 831172 139 63667404
Emphysematous cystitis 21.30 10.76 20 831169 208 63667335
Laryngeal mass 21.28 10.76 13 831176 65 63667478
Obstructive nephropathy 21.28 10.76 11 831178 37 63667506
Diabetes mellitus inadequate control 21.28 10.76 174 831015 21147 63646396
Therapeutic product effect delayed 21.27 10.76 77 831112 2482 63665061
Intestinal stenosis 21.27 10.76 90 831099 3124 63664419
Transfusion 21.25 10.76 140 831049 17854 63649689
Oral pain 21.22 10.76 239 830950 27254 63640289
Diaphragmatic hernia 21.20 10.76 24 831165 316 63667227
Haemorrhagic stroke 21.18 10.76 62 831127 9889 63657654
Blood triglycerides increased 21.18 10.76 149 831040 18717 63648826
Tendon disorder 21.13 10.76 147 831042 6185 63661358
Unintended pregnancy 21.12 10.76 7 831182 3127 63664416
Metastases to lung 21.07 10.76 113 831076 15151 63652392
Extrapulmonary tuberculosis 20.81 10.76 25 831164 352 63667191
Tongue oedema 20.80 10.76 28 831161 5962 63661581
Plasmablastic lymphoma 20.77 10.76 26 831163 383 63667160
Osteoarthritis 20.76 10.76 1007 830182 62329 63605214
Malignant melanoma 20.76 10.76 257 830932 12707 63654836
Homicidal ideation 20.71 10.76 8 831181 3249 63664294
Blood bicarbonate decreased 20.69 10.76 19 831170 4810 63662733
Diabetic cardiomyopathy 20.66 10.76 10 831179 28 63667515
Taste disorder 20.65 10.76 58 831131 9375 63658168
Cutaneous coccidioidomycosis 20.62 10.76 9 831180 18 63667525
Abscess bacterial 20.62 10.76 36 831153 725 63666818
Coombs positive haemolytic anaemia 20.58 10.76 39 831150 839 63666704
Gastroenteritis cryptosporidial 20.56 10.76 21 831168 244 63667299
Incontinence 20.48 10.76 83 831106 11998 63655545
Pneumonia necrotising 20.41 10.76 40 831149 883 63666660
C-reactive protein increased 20.40 10.76 1453 829736 93456 63574087
Cholelithiasis 20.33 10.76 439 830750 45067 63622476
Hallucinations, mixed 20.30 10.76 29 831160 6023 63661520
Injection site bruising 20.23 10.76 613 830576 35760 63631783
Mitochondrial toxicity 20.16 10.76 5 831184 2701 63664842
Pseudomonas aeruginosa meningitis 20.14 10.76 8 831181 11 63667532
Peripheral arterial occlusive disease 20.14 10.76 37 831152 6950 63660593
Corynebacterium infection 20.11 10.76 41 831148 932 63666611
Pleural mesothelioma malignant 20.11 10.76 17 831172 152 63667391
Caesarean section 20.04 10.76 76 831113 11198 63656345
Colitis microscopic 19.99 10.76 41 831148 7391 63660152
Acute hepatitis C 19.98 10.76 19 831170 201 63667342
Smoke sensitivity 19.97 10.76 28 831161 463 63667080
Kounis syndrome 19.96 10.76 7 831182 3018 63664525
Hernia 19.96 10.76 264 830925 13254 63654289
Cyst 19.94 10.76 240 830949 11787 63655756
Diarrhoea haemorrhagic 19.93 10.76 227 830962 11000 63656543
Superinfection bacterial 19.87 10.76 46 831143 1144 63666399
Pregnancy with contraceptive device 19.85 10.76 8 831181 3166 63664377
Alcohol use 19.85 10.76 18 831171 4584 63662959
Rectal prolapse 19.83 10.76 58 831131 1668 63665875
Sinusitis bacterial 19.80 10.76 45 831144 1105 63666438
Neurosarcoidosis 19.74 10.76 23 831166 313 63667230
Lung diffusion test decreased 19.71 10.76 46 831143 1150 63666393
Urine output decreased 19.63 10.76 128 831061 16364 63651179
Contusion 19.63 10.76 1715 829474 112250 63555293
Urine ketone body present 19.62 10.76 9 831180 3298 63664245
Aspiration 19.62 10.76 132 831057 16753 63650790
Gastrointestinal inflammation 19.61 10.76 142 831047 6053 63661490
Herpes simplex encephalitis 19.60 10.76 32 831157 609 63666934
Dysuria 19.59 10.76 403 830786 41654 63625889
Haemolytic uraemic syndrome 19.58 10.76 103 831086 3918 63663625
Lymphocyte count decreased 19.55 10.76 388 830801 40311 63627232
International normalised ratio decreased 19.49 10.76 42 831147 7436 63660107
Sickle cell anaemia with crisis 19.47 10.76 24 831165 5308 63662235
Systemic bacterial infection 19.43 10.76 9 831180 22 63667521
Rhinovirus infection 19.43 10.76 141 831048 6015 63661528
Bronchopleural fistula 19.40 10.76 31 831158 579 63666964
Pneumonia klebsiella 19.38 10.76 103 831086 3934 63663609
Abscess limb 19.38 10.76 141 831048 6020 63661523
Complication of device removal 19.35 10.76 9 831180 3271 63664272
Carpal tunnel syndrome 19.33 10.76 299 830890 15529 63652014
Mitral valve incompetence 19.32 10.76 223 830966 25315 63642228
Erythropoiesis abnormal 19.27 10.76 26 831163 414 63667129
Cytology abnormal 19.25 10.76 23 831166 322 63667221
Abdominal pain upper 19.22 10.76 1968 829221 173062 63494481
Tic 19.20 10.76 5 831184 2614 63664929
Autoinflammatory disease 19.20 10.76 16 831173 140 63667403
Morganella infection 19.17 10.76 41 831148 965 63666578
Bordetella infection 19.03 10.76 14 831175 100 63667443
Acute hepatic failure 18.99 10.76 230 830959 25882 63641661
Aplasia pure red cell 18.98 10.76 155 831034 6859 63660684
Prophylaxis against transplant rejection 18.98 10.76 11 831178 49 63667494
Tachypnoea 18.96 10.76 235 830954 26336 63641207
Chronic myeloid leukaemia 18.96 10.76 90 831099 3284 63664259
Pruritus allergic 18.93 10.76 38 831151 854 63666689
Prescribed overdose 18.91 10.76 169 831020 20162 63647381
Substance-induced psychotic disorder 18.90 10.76 78 831111 2677 63664866
Post procedural haemorrhage 18.89 10.76 89 831100 12342 63655201
Skin squamous cell carcinoma recurrent 18.85 10.76 10 831179 36 63667507
Intestinal resection 18.84 10.76 84 831105 2984 63664559
Pneumonia 18.82 10.76 7736 823453 551840 63115703
Endophthalmitis 18.76 10.76 126 831063 5239 63662304
Swollen joint count increased 18.74 10.76 166 831023 7523 63660020
Electrocardiogram ST segment elevation 18.73 10.76 41 831148 7218 63660325
Segmental diverticular colitis 18.67 10.76 15 831174 124 63667419
Cholecystitis acute 18.67 10.76 79 831110 11281 63656262
Metastatic squamous cell carcinoma 18.63 10.76 26 831163 428 63667115
Ejection fraction decreased 18.61 10.76 259 830930 28448 63639095
Eosinophil count 18.60 10.76 14 831175 104 63667439
Product dispensing error 18.58 10.76 80 831109 11370 63656173
Abdominal wall infection 18.57 10.76 13 831176 85 63667458
Metastases to bone 18.51 10.76 171 831018 20264 63647279
Isosporiasis 18.49 10.76 14 831175 105 63667438
Acinetobacter infection 18.45 10.76 71 831118 2358 63665185
Ear infection 18.43 10.76 413 830776 22991 63644552
Pyogenic granuloma 18.41 10.76 26 831163 433 63667110
Emotional distress 18.40 10.76 340 830849 35698 63631845
Injury 18.38 10.76 565 830624 55427 63612116
Nodal rhythm 18.38 10.76 7 831182 2867 63664676
Upper respiratory tract infection 18.27 10.76 1129 830060 71656 63595887
Arteriosclerosis coronary artery 18.25 10.76 121 831068 15408 63652135
Cardioactive drug level increased 18.24 10.76 11 831178 3454 63664089
Prosthesis user 18.21 10.76 12 831177 70 63667473
Syringe issue 18.20 10.76 17 831172 4269 63663274
Acquired haemophilia 18.20 10.76 54 831135 1566 63665977
Skin fragility 18.15 10.76 35 831154 763 63666780
Gynaecomastia 18.11 10.76 31 831158 5985 63661558
Rhegmatogenous retinal detachment 18.11 10.76 15 831174 130 63667413
Product physical issue 18.09 10.76 11 831178 3438 63664105
Hypomania 18.09 10.76 28 831161 5626 63661917
Pseudomembranous colitis 18.08 10.76 22 831167 4894 63662649
Ovarian hyperstimulation syndrome 18.07 10.76 7 831182 2838 63664705
Blood pH decreased 18.07 10.76 18 831171 4384 63663159
Cytomegalovirus oesophagitis 18.04 10.76 30 831159 580 63666963
Sciatica 18.03 10.76 364 830825 19900 63647643
Respiratory tract infection fungal 18.00 10.76 42 831147 1050 63666493
Hepatitis acute 18.00 10.76 100 831089 13289 63654254
Nasal turbinate hypertrophy 17.98 10.76 29 831160 546 63666997
Tumour lysis syndrome 17.90 10.76 351 830838 19089 63648454
Antineutrophil cytoplasmic antibody positive 17.87 10.76 40 831149 972 63666571
Psychomotor skills impaired 17.86 10.76 14 831175 3831 63663712
Pneumatosis intestinalis 17.81 10.76 122 831067 5107 63662436
Endocarditis Q fever 17.79 10.76 6 831183 3 63667540
Oral candidiasis 17.78 10.76 408 830781 22804 63644739
Erythema nodosum 17.77 10.76 100 831089 3904 63663639
Intermenstrual bleeding 17.75 10.76 24 831165 5101 63662442
Pleural effusion 17.68 10.76 1397 829792 125162 63542381
Transplant failure 17.67 10.76 96 831093 3698 63663845
Joint warmth 17.65 10.76 49 831140 1367 63666176
Clear cell renal cell carcinoma 17.64 10.76 65 831124 2114 63665429
Bronchial neoplasm 17.63 10.76 25 831164 418 63667125
Application site pruritus 17.59 10.76 12 831177 3527 63664016
Viral vasculitis 17.58 10.76 15 831174 136 63667407
Osteomyelitis 17.58 10.76 473 830716 27114 63640429
Granulomatous dermatitis 17.57 10.76 22 831167 324 63667219
Ejection fraction 17.53 10.76 46 831143 1240 63666303
Growth retardation 17.50 10.76 52 831137 1509 63666034
Gastroenteritis sapovirus 17.50 10.76 15 831174 137 63667406
Ileal stenosis 17.47 10.76 63 831126 2027 63665516
Eye movement disorder 17.44 10.76 41 831148 7038 63660505
Panic attack 17.44 10.76 179 831010 20774 63646769
Sinusitis fungal 17.42 10.76 55 831134 1651 63665892
Chronic graft versus host disease oral 17.41 10.76 11 831178 59 63667484
Urticaria 17.41 10.76 2161 829028 145156 63522387
Broncholithiasis 17.41 10.76 15 831174 138 63667405
Cutaneous mucormycosis 17.40 10.76 14 831175 116 63667427
Pyoderma gangrenosum 17.39 10.76 83 831106 3035 63664508
Multiple-drug resistance 17.38 10.76 36 831153 6466 63661077
Throat clearing 17.37 10.76 47 831142 1291 63666252
Drug level above therapeutic 17.35 10.76 150 831039 6751 63660792
Neck deformity 17.30 10.76 55 831134 1657 63665886
Graft versus host disease 17.28 10.76 262 830927 13551 63653992
Acute polyneuropathy 17.24 10.76 23 831166 362 63667181
Anal abscess 17.24 10.76 160 831029 7348 63660195
Herpes simplex oesophagitis 17.20 10.76 19 831170 243 63667300
Sleep apnoea syndrome 17.20 10.76 505 830684 29327 63638216
Antibody test positive 17.19 10.76 69 831120 2338 63665205
Urinary tract infection bacterial 17.15 10.76 119 831070 5002 63662541
Perinephric collection 17.15 10.76 21 831168 302 63667241
Oesophageal varices haemorrhage 17.12 10.76 13 831176 3616 63663927
Embedded device 17.11 10.76 7 831182 2745 63664798
Biloma 17.07 10.76 15 831174 142 63667401
Eructation 16.97 10.76 61 831128 9130 63658413
Anaesthetic complication 16.97 10.76 6 831183 2573 63664970
Hypofibrinogenaemia 16.96 10.76 56 831133 1722 63665821
Vocal cord dysfunction 16.94 10.76 24 831165 401 63667142
Chronic hepatitis 16.93 10.76 45 831144 1223 63666320
Pedal pulse abnormal 16.91 10.76 15 831174 144 63667399
Disseminated intravascular coagulation 16.89 10.76 304 830885 32044 63635499
Skin infection 16.84 10.76 280 830909 14757 63652786
Nephrolithiasis 16.82 10.76 706 830483 42977 63624566
Diplopia 16.82 10.76 243 830946 26522 63641021
Haemorrhage 16.80 10.76 843 830346 78508 63589035
Pneumonia acinetobacter 16.75 10.76 14 831175 123 63667420
Encephalitis brain stem 16.74 10.76 17 831172 196 63667347
Neurocryptococcosis 16.72 10.76 7 831182 12 63667531
Localised infection 16.69 10.76 508 830681 29653 63637890
Blood lactic acid increased 16.68 10.76 73 831116 10328 63657215
Cytomegalovirus enteritis 16.67 10.76 31 831158 657 63666886
Extradural abscess 16.65 10.76 43 831146 1148 63666395
Multiple fractures 16.63 10.76 134 831055 5906 63661637
Blood cholesterol 16.60 10.76 22 831167 344 63667199
Sarcoma of skin 16.59 10.76 11 831178 65 63667478
Pleural fibrosis 16.57 10.76 99 831090 3951 63663592
Bezoar 16.55 10.76 4 831185 2199 63665344
Acidosis 16.52 10.76 148 831041 17647 63649896
T-cell type acute leukaemia 16.51 10.76 15 831174 149 63667394
Transitional cell carcinoma 16.48 10.76 65 831124 2184 63665359
Visual impairment 16.46 10.76 783 830406 73294 63594249
Tachyarrhythmia 16.42 10.76 33 831156 5993 63661550
Sudden cardiac death 16.38 10.76 21 831168 4566 63662977
Affect lability 16.38 10.76 60 831129 8930 63658613
Skin graft rejection 16.38 10.76 8 831181 23 63667520
Abscess intestinal 16.33 10.76 67 831122 2293 63665250
Dyspepsia 16.28 10.76 857 830332 79455 63588088
Listeria encephalitis 16.26 10.76 20 831169 289 63667254
Human herpes virus 8 test positive 16.26 10.76 9 831180 36 63667507
Nasal disorder 16.26 10.76 77 831112 2807 63664736
Arthritis infective 16.23 10.76 150 831039 6880 63660663
Enterocolonic fistula 16.23 10.76 14 831175 129 63667414
Logorrhoea 16.20 10.76 17 831172 4042 63663501
Bacteraemia 16.19 10.76 458 830731 26453 63641090
Paranasal sinus discomfort 16.18 10.76 82 831107 3073 63664470
Cryptitis 16.17 10.76 12 831177 87 63667456
Injection site hypersensitivity 16.12 10.76 53 831136 1626 63665917
Renal cell carcinoma stage I 16.07 10.76 9 831180 37 63667506
Diverticulitis intestinal perforated 16.07 10.76 10 831179 52 63667491
Retroperitoneal lymphadenopathy 16.06 10.76 37 831152 917 63666626
Acute coronary syndrome 16.05 10.76 165 831024 19145 63648398
Extrasystoles 16.05 10.76 39 831150 6619 63660924
Multiple allergies 16.02 10.76 129 831060 5685 63661858
Sinus arrest 16.00 10.76 10 831179 3080 63664463
Faecal calprotectin abnormal 15.98 10.76 14 831175 132 63667411
Cross sensitivity reaction 15.97 10.76 12 831177 3355 63664188
Chemical peritonitis 15.95 10.76 19 831170 265 63667278
Blood chloride decreased 15.94 10.76 46 831143 7370 63660173
Nasal obstruction 15.94 10.76 46 831143 1313 63666230
Enuresis 15.93 10.76 8 831181 2782 63664761
Cerebellar haemorrhage 15.92 10.76 7 831182 2630 63664913
Low density lipoprotein increased 15.92 10.76 49 831140 7691 63659852
Haemophilus infection 15.91 10.76 57 831132 1828 63665715
Gastric haemorrhage 15.86 10.76 105 831084 13376 63654167
Carotid artery occlusion 15.84 10.76 17 831172 4000 63663543
Rheumatoid factor negative 15.84 10.76 40 831149 1053 63666490
Blood urea decreased 15.74 10.76 8 831181 2763 63664780
Thyroid gland abscess 15.71 10.76 11 831178 72 63667471
Underdose 15.71 10.76 236 830953 25593 63641950
Product adhesion issue 15.70 10.76 6 831183 2453 63665090
Toxic encephalopathy 15.67 10.76 69 831120 9746 63657797
International normalised ratio abnormal 15.67 10.76 25 831164 4963 63662580
Pericarditis infective 15.67 10.76 13 831176 113 63667430
Folate deficiency 15.66 10.76 8 831181 2755 63664788
Moraxella infection 15.66 10.76 26 831163 502 63667041
Embolic stroke 15.64 10.76 40 831149 6671 63660872
Lupus vasculitis 15.64 10.76 25 831164 467 63667076
Application site pain 15.64 10.76 19 831170 4229 63663314
Anal incontinence 15.63 10.76 123 831066 15073 63652470
Pulseless electrical activity 15.61 10.76 98 831091 12641 63654902
Alveolar osteitis 15.61 10.76 23 831166 399 63667144
Hyperammonaemia 15.59 10.76 70 831119 9834 63657709
Liver transplant failure 15.58 10.76 13 831176 114 63667429
Walking aid user 15.52 10.76 136 831053 6145 63661398
Inadequate analgesia 15.50 10.76 17 831172 3961 63663582
Anger 15.46 10.76 129 831060 15612 63651931
Malacoplakia gastrointestinal 15.46 10.76 15 831174 163 63667380
Meningitis haemophilus 15.43 10.76 7 831182 16 63667527
Incoherent 15.41 10.76 44 831145 7074 63660469
Neck mass 15.38 10.76 97 831092 3947 63663596
Meningitis coccidioides 15.38 10.76 9 831180 41 63667502
Oxygen saturation decreased 15.36 10.76 1592 829597 105584 63561959
Lacunar infarction 15.32 10.76 30 831159 5502 63662041
Pancreatitis 15.32 10.76 620 830569 58987 63608556
Ototoxicity 15.26 10.76 8 831181 2715 63664828
Platelet count abnormal 15.25 10.76 98 831091 4014 63663529
Potentiating drug interaction 15.25 10.76 51 831138 7801 63659742
Zoonotic bacterial infection 15.22 10.76 10 831179 58 63667485
Meningitis histoplasma 15.21 10.76 6 831183 8 63667535
Blood iron abnormal 15.20 10.76 41 831148 1124 63666419
Parainfluenzae virus infection 15.18 10.76 109 831080 4634 63662909
Dermatomyositis 15.15 10.76 74 831115 2732 63664811
Dermatitis bullous 15.15 10.76 92 831097 11962 63655581
Foot fracture 15.12 10.76 323 830866 17834 63649709
Hepatitis C RNA increased 15.08 10.76 22 831167 378 63667165
Metabolic alkalosis 15.07 10.76 17 831172 3911 63663632
Forced expiratory flow decreased 15.06 10.76 17 831172 223 63667320
Incision site pain 15.06 10.76 71 831118 2583 63664960
Kyphosis 15.06 10.76 66 831123 2327 63665216
Major depression 15.02 10.76 51 831138 7765 63659778
Libido decreased 15.01 10.76 24 831165 4760 63662783
Prostate cancer metastatic 14.98 10.76 83 831106 3221 63664322
Haemorrhagic transformation stroke 14.98 10.76 6 831183 2383 63665160
Peritoneal dialysis complication 14.97 10.76 5 831184 2223 63665320
Hepatosplenomegaly 14.96 10.76 119 831070 5224 63662319
Tendon rupture 14.96 10.76 208 830981 10559 63656984
Enterocolitis 14.96 10.76 92 831097 11926 63655617
Pulmonary sarcoidosis 14.96 10.76 40 831149 1091 63666452
Tooth abscess 14.96 10.76 256 830933 13570 63653973
Pericardial effusion 14.95 10.76 388 830801 38866 63628677
Cardiomyopathy acute 14.95 10.76 17 831172 225 63667318
Pulmonary embolism 14.94 10.76 1654 829535 144702 63522841
Pseudomonal sepsis 14.93 10.76 116 831073 5056 63662487
Polydipsia 14.92 10.76 33 831156 5788 63661755
Gastrooesophageal reflux disease 14.91 10.76 1255 829934 81888 63585655
Grip strength decreased 14.91 10.76 223 830966 11501 63656042
Paronychia 14.90 10.76 39 831150 6453 63661090
Spinal disorder 14.88 10.76 175 831014 8547 63658996
Atlantoaxial instability 14.87 10.76 19 831170 286 63667257
Combined immunodeficiency 14.86 10.76 12 831177 100 63667443
Porokeratosis 14.83 10.76 17 831172 227 63667316
Birdshot chorioretinopathy 14.83 10.76 10 831179 61 63667482
Joint lock 14.82 10.76 74 831115 2757 63664786
Temporal lobe epilepsy 14.82 10.76 21 831168 351 63667192
Antinuclear antibody positive 14.76 10.76 134 831055 6116 63661427
Bedridden 14.75 10.76 197 830992 9912 63657631
Lyme disease 14.74 10.76 66 831123 2349 63665194
Hemiparesis 14.74 10.76 283 830906 29544 63637999
Ecthyma 14.72 10.76 28 831161 604 63666939
Hepatic cancer 14.72 10.76 48 831141 7400 63660143
Glomerulosclerosis 14.70 10.76 36 831153 929 63666614
Epstein-Barr virus antigen positive 14.69 10.76 11 831178 81 63667462
Salmonella bacteraemia 14.67 10.76 19 831170 290 63667253
Blister 14.66 10.76 1223 829966 79744 63587799
Product complaint 14.63 10.76 92 831097 11862 63655681
Oesophageal stenosis 14.60 10.76 92 831097 3742 63663801
Urinoma 14.57 10.76 15 831174 176 63667367
Myasthenia gravis crisis 14.57 10.76 34 831155 850 63666693
Skin atrophy 14.57 10.76 111 831078 4809 63662734
Bone density abnormal 14.54 10.76 72 831117 2673 63664870
Diverticular perforation 14.54 10.76 116 831073 5097 63662446
Increased viscosity of bronchial secretion 14.54 10.76 24 831165 461 63667082
International normalised ratio fluctuation 14.52 10.76 76 831113 2885 63664658
Perinephric abscess 14.52 10.76 16 831173 204 63667339
Pulmonary function test increased 14.51 10.76 5 831184 3 63667540
Enterobiasis 14.51 10.76 5 831184 3 63667540
Compartment syndrome 14.48 10.76 20 831169 4212 63663331
Chronic granulomatous disease 14.45 10.76 8 831181 32 63667511
Abdominal distension 14.45 10.76 1053 830136 94941 63572602
Superior sagittal sinus thrombosis 14.44 10.76 36 831153 940 63666603
Virologic failure 14.42 10.76 14 831175 3452 63664091
Abnormal loss of weight 14.41 10.76 48 831141 7352 63660191
Transient acantholytic dermatosis 14.38 10.76 11 831178 84 63667459
Viral skin infection 14.38 10.76 11 831178 84 63667459
Behaviour disorder 14.37 10.76 22 831167 4440 63663103
Rheumatic fever 14.35 10.76 183 831006 9111 63658432
Metabolic encephalopathy 14.33 10.76 54 831135 7971 63659572
Refusal of treatment by patient 14.32 10.76 57 831132 8282 63659261
BK polyomavirus test positive 14.27 10.76 11 831178 85 63667458
Gastroenteritis viral 14.26 10.76 344 830845 19385 63648158
Fracture delayed union 14.25 10.76 57 831132 1928 63665615
Eye disorder 14.24 10.76 331 830858 18538 63649005
Anion gap increased 14.24 10.76 11 831178 3033 63664510
Blood pressure inadequately controlled 14.23 10.76 30 831159 5354 63662189
Renal vein thrombosis 14.22 10.76 23 831166 434 63667109
Intervertebral disc degeneration 14.22 10.76 243 830946 12877 63654666
Congenital hiatus hernia 14.19 10.76 22 831167 400 63667143
Chronic graft versus host disease in liver 14.18 10.76 26 831163 545 63666998
Limb injury 14.13 10.76 400 830789 23105 63644438
Ageusia 14.12 10.76 112 831077 13701 63653842
Graft thrombosis 14.11 10.76 22 831167 402 63667141
Mycobacterium kansasii infection 14.08 10.76 18 831171 271 63667272
Humoral immune defect 14.05 10.76 12 831177 109 63667434
Papilloedema 14.02 10.76 120 831069 5385 63662158
Alcoholism 13.99 10.76 14 831175 3403 63664140
Herpes dermatitis 13.97 10.76 11 831178 88 63667455
Fungal abscess central nervous system 13.96 10.76 12 831177 110 63667433
Illness 13.94 10.76 376 830813 21562 63645981
Atypical mycobacterial pneumonia 13.93 10.76 13 831176 134 63667409
Fungaemia 13.91 10.76 90 831099 3695 63663848
Disseminated varicella zoster vaccine virus infection 13.88 10.76 12 831177 111 63667432
Papilloma viral infection 13.87 10.76 46 831143 1418 63666125
Fungal endocarditis 13.86 10.76 24 831165 480 63667063
Tricuspid valve incompetence 13.84 10.76 146 831043 16857 63650686
Language disorder 13.79 10.76 9 831180 2708 63664835
Catatonia 13.79 10.76 51 831138 7569 63659974
Hemiplegia 13.77 10.76 102 831087 12666 63654877
Nephrectomy 13.75 10.76 45 831144 1377 63666166
Cutaneous malacoplakia 13.75 10.76 10 831179 70 63667473
Complications of transplanted liver 13.74 10.76 20 831169 343 63667200
Pneumonitis 13.73 10.76 787 830402 49578 63617965
Needle issue 13.73 10.76 67 831122 9205 63658338
Infectious thyroiditis 13.71 10.76 12 831177 113 63667430
Escherichia sepsis 13.69 10.76 147 831042 7018 63660525
Chromoblastomycosis 13.64 10.76 10 831179 71 63667472
Infective myositis 13.64 10.76 10 831179 71 63667472
Capnocytophaga infection 13.64 10.76 10 831179 71 63667472
Total lung capacity decreased 13.63 10.76 51 831138 1671 63665872
Vascular purpura 13.62 10.76 8 831181 2548 63664995
Shoulder arthroplasty 13.61 10.76 70 831119 2639 63664904
Drug level fluctuating 13.61 10.76 28 831161 641 63666902
Tumour pain 13.60 10.76 4 831185 1929 63665614
Coronary artery occlusion 13.57 10.76 114 831075 13777 63653766
Loss of libido 13.57 10.76 7 831182 2397 63665146
Pseudopolyp 13.53 10.76 21 831168 382 63667161
Meningitis bacterial 13.53 10.76 63 831126 2280 63665263
Torus fracture 13.53 10.76 10 831179 72 63667471
Hypoxic-ischaemic encephalopathy 13.52 10.76 47 831142 7105 63660438
Refractory cytopenia with unilineage dysplasia 13.51 10.76 32 831157 808 63666735
Complement factor C4 decreased 13.50 10.76 16 831173 222 63667321
Device deployment issue 13.49 10.76 10 831179 2816 63664727
Spinal instability 13.49 10.76 20 831169 349 63667194
Serositis 13.48 10.76 30 831159 726 63666817
Disinhibition 13.47 10.76 6 831183 2237 63665306
Symptom recurrence 13.46 10.76 34 831155 895 63666648
Fungal tracheitis 13.46 10.76 4 831185 0 63667543
Herpes zoster meningoradiculitis 13.46 10.76 4 831185 0 63667543
Erysipelothrix infection 13.46 10.76 4 831185 0 63667543
Nocardia test positive 13.46 10.76 4 831185 0 63667543
Arterial fibrosis 13.46 10.76 4 831185 0 63667543
Rabies 13.44 10.76 6 831183 13 63667530
Endometrial ablation 13.41 10.76 31 831158 770 63666773
Bronchial hyperreactivity 13.39 10.76 66 831123 2446 63665097
Cytomegalovirus infection reactivation 13.38 10.76 123 831066 5633 63661910
Breast cancer 13.37 10.76 280 830909 28868 63638675
Otorrhoea 13.27 10.76 46 831143 1451 63666092
Aplastic anaemia 13.26 10.76 115 831074 13805 63653738
Furuncle 13.25 10.76 134 831055 6299 63661244
Herpes simplex colitis 13.23 10.76 7 831182 25 63667518
Atrial flutter 13.23 10.76 173 831016 19207 63648336
Epstein-Barr virus infection reactivation 13.22 10.76 39 831150 1127 63666416
Wound infection 13.22 10.76 267 830922 14597 63652946
Oesophageal atresia 13.21 10.76 9 831180 56 63667487
Sinus disorder 13.20 10.76 298 830891 16610 63650933
Phospholipidosis 13.15 10.76 12 831177 120 63667423
Biliary hamartoma 13.14 10.76 6 831183 14 63667529
Blood thyroid stimulating hormone decreased 13.12 10.76 30 831159 5200 63662343
Teratogenicity 13.11 10.76 10 831179 76 63667467
Norovirus test positive 13.10 10.76 22 831167 429 63667114
Myocardial oedema 13.09 10.76 19 831170 325 63667218
Pancreas transplant 13.08 10.76 9 831180 57 63667486
Pericardial fibrosis 13.08 10.76 9 831180 57 63667486
Orbital myositis 13.07 10.76 13 831176 146 63667397
Anovulatory cycle 13.04 10.76 11 831178 98 63667445
Infection in an immunocompromised host 13.04 10.76 36 831153 1001 63666542
Peripheral coldness 13.04 10.76 112 831077 13472 63654071
Aspergilloma 12.98 10.76 23 831166 469 63667074
Perirectal abscess 12.97 10.76 52 831137 1761 63665782
Mineral metabolism disorder 12.96 10.76 18 831171 295 63667248
Pigment nephropathy 12.95 10.76 8 831181 41 63667502
Sinus arrhythmia 12.92 10.76 4 831185 1866 63665677
Glomerulonephritis 12.91 10.76 73 831116 2855 63664688
Erythema 12.90 10.76 2166 829023 184904 63482639
Hyperthyroidism 12.89 10.76 161 831028 18018 63649525
Ovarian cyst 12.87 10.76 86 831103 10932 63656611
Salpingo-oophorectomy unilateral 12.84 10.76 23 831166 473 63667070
Adrenal suppression 12.84 10.76 42 831147 1285 63666258
Cytopenia 12.82 10.76 275 830914 15196 63652347
Suicidal behaviour 12.80 10.76 11 831178 2876 63664667
Ventricular hypokinesia 12.78 10.76 54 831135 7715 63659828
Genital lesion 12.78 10.76 23 831166 475 63667068
Empyema 12.77 10.76 86 831103 3579 63663964
Osteomyelitis bacterial 12.74 10.76 22 831167 439 63667104
Liver injury 12.73 10.76 291 830898 29641 63637902
Tuberculosis liver 12.72 10.76 9 831180 60 63667483
Psychiatric decompensation 12.72 10.76 8 831181 2455 63665088
Lennox-Gastaut syndrome 12.72 10.76 15 831174 207 63667336
Autonomic nervous system imbalance 12.71 10.76 21 831168 4111 63663432
Factor XIII deficiency 12.70 10.76 10 831179 80 63667463
Adrenocortical insufficiency acute 12.69 10.76 66 831123 2499 63665044
Throat irritation 12.67 10.76 529 830660 32182 63635361
Acute hepatitis B 12.66 10.76 21 831168 405 63667138
Central nervous system infection 12.66 10.76 39 831150 1155 63666388
Nodular rash 12.65 10.76 18 831171 302 63667241
Acquired apparent mineralocorticoid excess 12.65 10.76 7 831182 28 63667515
Intervertebral disc compression 12.62 10.76 35 831154 976 63666567
Haemorrhage intracranial 12.61 10.76 224 830965 23660 63643883
Urinary hesitation 12.61 10.76 16 831173 3494 63664049
Forced expiratory volume 12.61 10.76 10 831179 81 63667462
Nerve injury 12.59 10.76 153 831036 7532 63660011
Intestinal ischaemia 12.58 10.76 92 831097 11457 63656086
Haemodialysis 12.58 10.76 150 831039 16927 63650616
Intestinal pseudo-obstruction 12.57 10.76 5 831184 1995 63665548
Tinnitus 12.57 10.76 339 830850 33794 63633749
Presbyacusis 12.57 10.76 66 831123 2509 63665034
Diffuse alveolar damage 12.55 10.76 78 831111 3157 63664386
Increased tendency to bruise 12.54 10.76 178 831011 9077 63658466
Blood chloride increased 12.50 10.76 27 831162 4776 63662767
Acute myelomonocytic leukaemia 12.49 10.76 17 831172 273 63667270
Anticonvulsant drug level decreased 12.49 10.76 4 831185 1826 63665717
Polycystic ovaries 12.49 10.76 58 831131 2097 63665446
Initial insomnia 12.47 10.76 36 831153 5768 63661775
Meningoencephalitis amoebic 12.47 10.76 12 831177 129 63667414
Vestibular disorder 12.47 10.76 7 831182 2286 63665257
Peripheral sensorimotor neuropathy 12.44 10.76 66 831123 2519 63665024
Vascular stent thrombosis 12.43 10.76 15 831174 3349 63664194
Hypervolaemia 12.40 10.76 387 830802 37898 63629645
Injection site induration 12.40 10.76 66 831123 8866 63658677
Tearfulness 12.38 10.76 26 831163 4647 63662896
Gastrointestinal stoma output abnormal 12.37 10.76 8 831181 45 63667498
Viral upper respiratory tract infection 12.36 10.76 161 831028 8054 63659489
Lymphadenopathy mediastinal 12.36 10.76 89 831100 3787 63663756
Nephritis haemorrhagic 12.34 10.76 6 831183 17 63667526
Actinic keratosis 12.33 10.76 111 831078 5054 63662489
Mediastinum neoplasm 12.32 10.76 10 831179 84 63667459
Hypoventilation 12.32 10.76 125 831064 5881 63661662
Drug withdrawal convulsions 12.31 10.76 6 831183 2122 63665421
Bone infarction 12.27 10.76 20 831169 380 63667163
Oesophageal infection 12.27 10.76 24 831165 529 63667014
Lymphoma 12.26 10.76 250 830939 13691 63653852
Pain in jaw 12.24 10.76 416 830773 40339 63627204
Dural arteriovenous fistula 12.23 10.76 8 831181 46 63667497
Pancreatitis chronic 12.21 10.76 17 831172 3569 63663974
Hepatic enzyme abnormal 12.20 10.76 122 831067 5717 63661826
Hypoaldosteronism 12.18 10.76 18 831171 313 63667230
Ear pruritus 12.18 10.76 67 831122 2593 63664950
Genitourinary tract infection 12.17 10.76 16 831173 248 63667295
Primary immunodeficiency syndrome 12.16 10.76 9 831180 65 63667478
Insomnia 12.15 10.76 2305 828884 195531 63472012
Cholangitis sclerosing 12.13 10.76 53 831136 1866 63665677
Post procedural discharge 12.13 10.76 25 831164 573 63666970
Acute pulmonary oedema 12.12 10.76 106 831083 12703 63654840
Drug specific antibody absent 12.12 10.76 12 831177 134 63667409
Ossicle disorder 12.11 10.76 7 831182 31 63667512
Small cell lung cancer recurrent 12.10 10.76 6 831183 18 63667525
Decubitus ulcer 12.10 10.76 112 831077 13267 63654276
Abdominal wall abscess 12.08 10.76 35 831154 1001 63666542
Lung consolidation 12.08 10.76 153 831036 7605 63659938
Disseminated large cell lymphoma 12.05 10.76 9 831180 66 63667477
Stress fracture 11.99 10.76 118 831071 5506 63662037
Blood stem cell harvest failure 11.96 10.76 10 831179 88 63667455
Blood calcium increased 11.92 10.76 63 831126 8479 63659064
Periorbital oedema 11.91 10.76 52 831137 7362 63660181
Knee deformity 11.90 10.76 32 831157 876 63666667
Anticonvulsant drug level increased 11.89 10.76 8 831181 2369 63665174
Intestinal anastomosis 11.87 10.76 22 831167 465 63667078
Urethral fistula 11.87 10.76 6 831183 19 63667524
Cardiac failure acute 11.87 10.76 144 831045 16200 63651343
Soft tissue injury 11.87 10.76 46 831143 1533 63666010
Injection site mass 11.85 10.76 154 831035 17116 63650427
Glomerulonephritis proliferative 11.85 10.76 19 831170 356 63667187
Bronchiolitis 11.84 10.76 84 831105 3557 63663986
Orthostatic intolerance 11.84 10.76 3 831186 1597 63665946
Ankylosing spondylitis 11.82 10.76 160 831029 8074 63659469
Graft versus host disease in skin 11.80 10.76 113 831076 5234 63662309
Pleomorphism 11.79 10.76 5 831184 9 63667534
Cholangitis 11.79 10.76 86 831103 10716 63656827
Drug level abnormal 11.79 10.76 13 831176 166 63667377
Rales 11.76 10.76 268 830921 14961 63652582
Unevaluable event 11.75 10.76 531 830658 49958 63617585
Urinary tract discomfort 11.74 10.76 18 831171 324 63667219
Hepatocellular carcinoma 11.72 10.76 62 831127 8341 63659202
Phaeohyphomycotic brain abscess 11.71 10.76 8 831181 50 63667493
Feeding intolerance 11.70 10.76 24 831165 548 63666995
Pneumococcal bacteraemia 11.69 10.76 10 831179 91 63667452
Amenorrhoea 11.68 10.76 44 831145 6495 63661048
Graft versus host disease in liver 11.67 10.76 45 831144 1496 63666047
Brain oedema 11.67 10.76 207 830982 21868 63645675
Graft complication 11.66 10.76 26 831163 630 63666913
Pleuropericarditis 11.66 10.76 20 831169 397 63667146
Splenic lesion 11.62 10.76 19 831170 362 63667181
Blood stem cell transplant failure 11.60 10.76 23 831166 512 63667031
Pruritus 11.59 10.76 3725 827464 308675 63358868
Genital herpes simplex 11.57 10.76 17 831172 294 63667249
Central nervous system enteroviral infection 11.53 10.76 9 831180 71 63667472
Urinary tract candidiasis 11.53 10.76 26 831163 635 63666908
Gambling disorder 11.48 10.76 5 831184 1889 63665654
Feeling abnormal 11.47 10.76 1527 829662 132075 63535468
Bunion operation 11.47 10.76 29 831160 764 63666779
Antibody test negative 11.46 10.76 7 831182 35 63667508
Transitional cell cancer of renal pelvis and ureter metastatic 11.46 10.76 5 831184 10 63667533
Hepatic angiosarcoma 11.46 10.76 5 831184 10 63667533
Pyelocaliectasis 11.45 10.76 30 831159 808 63666735
Tumour necrosis factor receptor-associated periodic syndrome 11.43 10.76 6 831183 21 63667522
Cardiac disorder 11.43 10.76 595 830594 55221 63612322
Product residue present 11.41 10.76 15 831174 3227 63664316
Computerised tomogram thorax abnormal 11.41 10.76 53 831136 1916 63665627
Supraventricular tachycardia 11.41 10.76 173 831016 18734 63648809
Ophthalmic herpes simplex 11.36 10.76 24 831165 560 63666983
Proteinuria 11.35 10.76 451 830738 27272 63640271
Hepatitis fulminant 11.35 10.76 42 831147 6232 63661311
Gastrointestinal mucormycosis 11.35 10.76 18 831171 334 63667209
Acute erythroid leukaemia 11.34 10.76 15 831174 234 63667309
Lung infiltration 11.34 10.76 351 830838 20538 63647005
Tuberculosis gastrointestinal 11.34 10.76 22 831167 482 63667061
Rectal tenesmus 11.33 10.76 35 831154 1038 63666505
Drug-induced liver injury 11.31 10.76 500 830689 47143 63620400
Immobile 11.31 10.76 123 831066 5892 63661651
Small intestinal stenosis 11.27 10.76 26 831163 645 63666898
Eye infection syphilitic 11.26 10.76 4 831185 3 63667540
Endocarditis histoplasma 11.26 10.76 4 831185 3 63667540
Trichosporon infection 11.25 10.76 31 831158 861 63666682
Physical assault 11.24 10.76 3 831186 1543 63666000
Hepatitis toxic 11.23 10.76 25 831164 4375 63663168
Splenic marginal zone lymphoma 11.23 10.76 6 831183 22 63667521
Catheter site erythema 11.23 10.76 29 831160 4820 63662723
Scleroderma 11.22 10.76 103 831086 4715 63662828
Renal injury 11.18 10.76 136 831053 15293 63652250
Renal cancer 11.18 10.76 48 831141 6827 63660716
Vascular rupture 11.18 10.76 40 831149 1282 63666261
Cryptococcus test positive 11.15 10.76 5 831184 11 63667532
Necrotising gastritis 11.14 10.76 9 831180 75 63667468
Dysphoria 11.14 10.76 25 831164 4363 63663180
Coronary artery bypass 11.13 10.76 38 831151 5777 63661766
Inflammatory pseudotumour 11.12 10.76 8 831181 55 63667488
Mediastinitis 11.09 10.76 29 831160 780 63666763
Drug resistance 11.07 10.76 556 830633 34546 63632997
Abscess fungal 11.06 10.76 15 831174 240 63667303
Postoperative wound infection 11.04 10.76 191 830998 10145 63657398
Cerebellar infarction 11.04 10.76 16 831173 3303 63664240
Vesicoureteric reflux 11.03 10.76 10 831179 99 63667444
Herpes zoster reactivation 11.03 10.76 10 831179 99 63667444
Necrotising fasciitis fungal 11.03 10.76 6 831183 23 63667520
Chorea 11.03 10.76 6 831183 1994 63665549
Rib fracture 11.02 10.76 396 830793 23642 63643901
Neutrophilic dermatosis 11.02 10.76 23 831166 532 63667011
Bone marrow tumour cell infiltration 11.02 10.76 7 831182 38 63667505
Postoperative thoracic procedure complication 11.00 10.76 8 831181 56 63667487
Vasomotor rhinitis 11.00 10.76 8 831181 56 63667487
Biopsy skin abnormal 10.99 10.76 13 831176 180 63667363
Marrow hyperplasia 10.96 10.76 41 831148 1343 63666200
Vitamin D deficiency 10.96 10.76 97 831092 11595 63655948
Colon cancer 10.94 10.76 108 831081 12631 63654912
Bone pain 10.94 10.76 501 830688 47071 63620472
Diffuse idiopathic skeletal hyperostosis 10.88 10.76 7 831182 39 63667504
Avian influenza 10.87 10.76 9 831180 78 63667465
Segmented hyalinising vasculitis 10.87 10.76 9 831180 78 63667465
Leiomyosarcoma metastatic 10.86 10.76 5 831184 12 63667531
Bone marrow granuloma 10.84 10.76 6 831183 24 63667519
Focal myositis 10.84 10.76 6 831183 24 63667519
Haemarthrosis 10.83 10.76 33 831156 5196 63662347
Spinal fracture 10.79 10.76 264 830925 14910 63652633
Sebaceous hyperplasia 10.78 10.76 8 831181 58 63667485
Posture abnormal 10.77 10.76 17 831172 3389 63664154
Blood iron decreased 10.77 10.76 218 830971 11924 63655619

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07EA03 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC H02AB07 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:37962 adrenergic agents
CHEBI has role CHEBI:50266 Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Thyroiditis indication 82119001 DOID:7166
Autoimmune disease indication 85828009
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Acute lymphoid leukemia indication 91857003 DOID:9952
Chronic lymphoid leukemia, disease indication 92814006
Disorder of skin indication 95320005 DOID:37
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Asthma indication 195967001 DOID:2841
Transplanted organ rejection indication 213148006
Adrenogenital disorder indication 267395000 DOID:0050811
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Prevention of Transplant Rejection indication
Erythroblastic Anemia indication
Systemic Dermatomyositis indication
Diffuse Proliferative Lupus Nephritis indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Pemphigoid off-label use 86142006
Myasthenia gravis off-label use 91637004 DOID:437
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Bell's palsy off-label use 193093009 DOID:12506
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Pure Red Cell Aplasia associated with Chronic Lymphocytic Leukemia off-label use
Metastatic Prostate Carcinoma off-label use
Neuroendocrine Prostate Carcinoma off-label use
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Cluster Headache Prevention off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Pregnancy, function contraindication 289908002
Varicella-zoster virus infection contraindication 309465005
Osteopenia contraindication 312894000
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Inflammation Indication
Dogs Inflammation Indication
Horses Inflammation Indication

🐶 Veterinary products

ProductApplicantIngredients
Meticorten Intervet Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.33 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 8309124 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED RELEASE 1, 2, OR 5 MG PREDNISONE TABLET
1MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 8394407 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
1MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9040085 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
1MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9186332 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
2MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 8394407 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
2MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9040085 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
2MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9186332 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
5MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 8309124 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED RELEASE 1, 2, OR 5 MG PREDNISONE TABLET
5MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 8394407 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
5MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9040085 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
5MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9186332 April 23, 2024 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
1MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9504699 Aug. 3, 2027 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
2MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9504699 Aug. 3, 2027 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
5MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 9504699 Aug. 3, 2027 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
5MG RAYOS HORIZON N202020 July 26, 2012 RX TABLET, DELAYED RELEASE ORAL 8168218 Jan. 7, 2028 TREATMENT OF RHEUMATOLOGIC, ALLERGIC, PULMONARY, GASTROINTESTINAL, DERMATOLOGIC DISEASES OR CONDITIONS BY THE USE OF A DELAYED RELEASE 5MG PREDNISONE TABLET

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8 WOMBAT-PK CHEMBL
Sodium/nucleoside cotransporter 1 Transporter Ki 5.77 DRUG MATRIX
Annexin A1 Cytosolic other WOMBAT-PK

External reference:

IDSource
4017876 VUID
N0000146229 NUI
D00473 KEGG_DRUG
4017876 VANDF
C0032952 UMLSCUI
CHEBI:8382 CHEBI
PDN PDB_CHEM_ID
CHEMBL635 ChEMBL_ID
DB00635 DRUGBANK_ID
D011241 MESH_DESCRIPTOR_UI
5865 PUBCHEM_CID
7096 IUPHAR_LIGAND_ID
536 INN_ID
VB0R961HZT UNII
8640 RXNORM
287 MMSL
5351 MMSL
72025 MMSL
d00350 MMSL
002164 NDDF
10312003 SNOMEDCT_US
116602009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0017 TABLET 10 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0018 TABLET 20 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0019 TABLET 50 mg ORAL ANDA 10 sections
PredniSONE Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3721 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-3722 SOLUTION 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4728 TABLET 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4741 TABLET 1 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4742 TABLET 2.50 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8724 TABLET 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8739 TABLET 1 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8740 TABLET 2.50 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-9817 TABLET 10 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-9818 TABLET 20 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-9828 TABLET 5 mg ORAL ANDA 10 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9738 TABLET 20 mg ORAL ANDA 18 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9739 TABLET 10 mg ORAL ANDA 18 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9740 TABLET 5 mg ORAL ANDA 18 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0640 TABLET 5 mg ORAL ANDA 21 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0641 TABLET 10 mg ORAL ANDA 21 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0642 TABLET 20 mg ORAL ANDA 21 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0440-8165 TABLET 5 mg ORAL ANDA 14 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0440-8167 TABLET 20 mg ORAL ANDA 14 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0463-6141 TABLET 20 mg ORAL ANDA 20 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0463-6155 TABLET 5 mg ORAL ANDA 20 sections
PREDNISONE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2930 TABLET 1 mg ORAL ANDA 10 sections
PREDNISONE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2931 TABLET 2.50 mg ORAL ANDA 13 sections
PREDNISONE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2932 TABLET 5 mg ORAL ANDA 13 sections
PREDNISONE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2933 TABLET 10 mg ORAL ANDA 13 sections
PREDNISONE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2934 TABLET 20 mg ORAL ANDA 13 sections
PREDNISONE HUMAN PRESCRIPTION DRUG LABEL 1 0527-2935 TABLET 50 mg ORAL ANDA 13 sections