dexamethasone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 824 50-02-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexamethasone
  • dexasone
  • dexmethsone
An anti-inflammatory 9-fluoro-glucocorticoid.
  • Molecular weight: 392.47
  • Formula: C22H29FO5
  • CLOGP: 1.79
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.89
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 mg O
1.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.09 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2.60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.33 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.94 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.32 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 30, 1958 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 2584.91 26.01 722 15365 7411 2334587
Pneumonia 1972.70 26.01 944 15143 48352 2293646
Neutropenia 1911.59 26.01 727 15360 20821 2321177
Thrombocytopenia 1737.48 26.01 657 15430 18474 2323524
Febrile neutropenia 1548.85 26.01 522 15565 10360 2331638
Diarrhoea 1288.24 26.01 857 15230 82707 2259291
Neuropathy peripheral 1277.29 26.01 458 15629 10974 2331024
Pyrexia 1190.63 26.01 695 15392 53013 2288985
Sepsis 1166.90 26.01 489 15598 17999 2323999
Anaemia 1100.57 26.01 570 15517 34222 2307776
Febrile bone marrow aplasia 849.81 26.01 190 15897 667 2341331
Fatigue 841.83 26.01 668 15419 84205 2257793
Acute kidney injury 775.37 26.01 421 15666 27701 2314297
Pancytopenia 755.20 26.01 313 15774 11139 2330859
Off label use 743.30 26.01 586 15501 73012 2268986
Septic shock 731.99 26.01 268 15819 6786 2335212
Nausea 689.63 26.01 673 15414 111516 2230482
Vomiting 679.70 26.01 550 15537 71052 2270946
Disease progression 646.99 26.01 317 15770 16778 2325220
Dyspnoea 621.81 26.01 544 15543 78189 2263809
Hypotension 600.06 26.01 375 15712 32061 2309937
Asthenia 561.17 26.01 414 15673 46512 2295486
Hyperglycaemia 549.12 26.01 197 15890 4688 2337310
Constipation 543.66 26.01 305 15782 21324 2320674
Platelet count decreased 506.39 26.01 262 15825 15551 2326447
Drug ineffective 500.35 26.01 542 15545 101082 2240916
Product use in unapproved indication 475.78 26.01 225 15862 10975 2331023
Deep vein thrombosis 471.60 26.01 234 15853 12698 2329300
Mucosal inflammation 463.22 26.01 177 15910 5047 2336951
Leukopenia 436.61 26.01 206 15881 9990 2332008
Posterior reversible encephalopathy syndrome 436.17 26.01 140 15947 2340 2339658
Dehydration 414.78 26.01 259 15828 22036 2319962
Pulmonary embolism 403.20 26.01 236 15851 17847 2324151
Neutrophil count decreased 397.23 26.01 169 15918 6398 2335600
Venoocclusive liver disease 391.55 26.01 95 15992 513 2341485
Rash 381.88 26.01 367 15720 59191 2282807
Hypokalaemia 380.07 26.01 190 15897 10464 2331534
Multiple organ dysfunction syndrome 378.98 26.01 171 15916 7470 2334528
Renal failure 359.48 26.01 216 15871 17133 2324865
Malignant neoplasm progression 354.00 26.01 189 15898 11939 2330059
Plasma cell myeloma recurrent 351.18 26.01 79 16008 286 2341712
White blood cell count decreased 349.84 26.01 216 15871 17992 2324006
Lower respiratory tract infection 339.34 26.01 143 15944 5281 2336717
Infection 336.55 26.01 210 15877 17819 2324179
Haemoglobin decreased 335.25 26.01 210 15877 17941 2324057
Neutropenic sepsis 331.69 26.01 100 15987 1342 2340656
General physical health deterioration 329.54 26.01 190 15897 13949 2328049
Tumour lysis syndrome 324.25 26.01 92 15995 983 2341015
Hyponatraemia 323.77 26.01 184 15903 13141 2328857
Urinary tract infection 314.62 26.01 245 15842 29697 2312301
Respiratory failure 313.15 26.01 181 15906 13347 2328651
Osteonecrosis 310.05 26.01 147 15940 7195 2334803
Bone marrow failure 306.72 26.01 135 15952 5551 2336447
Plasmacytoma 299.19 26.01 70 16017 314 2341684
Abdominal pain 297.22 26.01 251 15836 34123 2307875
Cytomegalovirus infection 288.18 26.01 105 15982 2608 2339390
Oedema peripheral 286.14 26.01 211 15876 23552 2318446
Insomnia 281.71 26.01 216 15871 25571 2316427
Pleural effusion 280.39 26.01 160 15927 11508 2330490
Blood glucose increased 264.78 26.01 157 15930 12133 2329865
Colitis 262.35 26.01 118 15969 5108 2336890
Haematotoxicity 260.11 26.01 79 16008 1088 2340910
Hypercalcaemia 251.99 26.01 94 15993 2498 2339500
Haemophagocytic lymphohistiocytosis 251.01 26.01 80 16007 1303 2340695
Myelodysplastic syndrome 245.81 26.01 92 15995 2468 2339530
Hypertriglyceridaemia 240.36 26.01 70 16017 826 2341172
Respiratory tract infection 237.94 26.01 102 15985 3927 2338071
Pneumocystis jirovecii pneumonia 237.79 26.01 87 16000 2186 2339812
Decreased appetite 237.40 26.01 205 15882 28686 2313312
Back pain 234.92 26.01 212 15875 31447 2310551
Confusional state 223.14 26.01 184 15903 24160 2317838
Hypertension 218.42 26.01 191 15896 27170 2314828
Weight increased 217.71 26.01 175 15912 22162 2319836
Atrial fibrillation 216.33 26.01 144 15943 13624 2328374
Hypoxia 215.87 26.01 109 15978 6118 2335880
Cough 213.35 26.01 205 15882 32912 2309086
Muscular weakness 206.04 26.01 144 15943 14753 2327245
Peripheral sensory neuropathy 201.10 26.01 63 16024 967 2341031
Breast cancer 201.07 26.01 120 15967 9375 2332623
Drug interaction 200.16 26.01 187 15900 28976 2313022
Malaise 199.45 26.01 253 15834 55332 2286666
Syncope 194.37 26.01 146 15941 16729 2325269
Cytopenia 194.01 26.01 61 16026 948 2341050
Lymphopenia 192.04 26.01 76 16011 2378 2339620
Bacteraemia 191.32 26.01 69 16018 1661 2340337
Seizure 189.63 26.01 168 15919 24298 2317700
C-reactive protein increased 186.63 26.01 99 15988 6156 2335842
Dizziness 185.60 26.01 251 15836 58414 2283584
Acute lymphocytic leukaemia recurrent 185.39 26.01 43 16044 184 2341814
Plasma cell leukaemia 184.52 26.01 41 16046 138 2341860
Myopathy 183.70 26.01 65 16022 1478 2340520
Tachycardia 182.41 26.01 139 15948 16270 2325728
Blood creatinine increased 182.12 26.01 117 15970 10416 2331582
Aspergillus infection 180.10 26.01 57 16030 906 2341092
Polyneuropathy 178.92 26.01 66 16021 1697 2340301
Alanine aminotransferase increased 178.70 26.01 129 15958 13903 2328095
Candida infection 177.12 26.01 75 16012 2798 2339200
Cardiac failure 176.83 26.01 121 15966 11973 2330025
Hypocalcaemia 173.86 26.01 81 16006 3802 2338196
Herpes zoster 173.03 26.01 110 15977 9615 2332383
Exposure during pregnancy 167.79 26.01 159 15928 25060 2316938
Tremor 164.32 26.01 144 15943 20517 2321481
Hepatocellular injury 161.39 26.01 78 16009 3977 2338021
Headache 161.37 26.01 278 15809 79901 2262097
Condition aggravated 155.12 26.01 170 15917 31809 2310189
Oral candidiasis 154.25 26.01 61 16026 1904 2340094
Foetal exposure during pregnancy 153.49 26.01 82 16005 5170 2336828
Endophthalmitis 153.18 26.01 48 16039 737 2341261
Cushing's syndrome 152.94 26.01 48 16039 741 2341257
Acute myeloid leukaemia 151.43 26.01 66 16021 2644 2339354
Stomatitis 151.12 26.01 101 15986 9609 2332389
Premature delivery 150.26 26.01 69 16018 3131 2338867
Renal impairment 147.58 26.01 101 15986 9991 2332007
Blood culture positive 147.12 26.01 46 16041 701 2341297
Death 146.58 26.01 269 15818 81199 2260799
Hyperbilirubinaemia 146.25 26.01 55 16032 1494 2340504
Hypersensitivity 146.07 26.01 143 15944 23450 2318548
Mental status changes 143.32 26.01 80 16007 5502 2336496
Rash maculo-papular 143.16 26.01 73 16014 4179 2337819
Vision blurred 142.97 26.01 115 15972 14553 2327445
Neurotoxicity 142.68 26.01 59 16028 2071 2339927
Anaphylactic shock 139.72 26.01 72 16015 4214 2337784
Acute lymphocytic leukaemia 139.05 26.01 40 16047 450 2341548
Weight decreased 137.87 26.01 151 15936 28220 2313778
Maternal exposure during pregnancy 137.42 26.01 113 15974 14750 2327248
Hypofibrinogenaemia 136.33 26.01 31 16056 119 2341879
Hypophagia 135.62 26.01 69 16018 3931 2338067
Product use issue 135.00 26.01 103 15984 12066 2329932
Bronchitis 134.67 26.01 108 15979 13606 2328392
Adrenal insufficiency 133.23 26.01 50 16037 1350 2340648
Basal cell carcinoma 132.66 26.01 60 16027 2627 2339371
Disseminated intravascular coagulation 131.98 26.01 64 16023 3286 2338712
Premature baby 131.64 26.01 63 16024 3141 2338857
Staphylococcal sepsis 131.10 26.01 46 16041 1019 2340979
Cardiac arrest 130.74 26.01 110 15977 14820 2327178
Clostridium difficile colitis 130.56 26.01 55 16032 2024 2339974
Pulmonary oedema 130.24 26.01 83 16004 7280 2334718
Bone pain 129.09 26.01 89 15998 8907 2333091
Cataract 128.50 26.01 76 16011 5832 2336166
Electrolyte imbalance 128.29 26.01 54 16033 1983 2340015
Therapy non-responder 127.79 26.01 85 16002 8019 2333979
Erythema 127.63 26.01 137 15950 25022 2316976
Disease recurrence 127.19 26.01 63 16024 3388 2338610
Atelectasis 126.80 26.01 53 16034 1912 2340086
Systemic candida 125.51 26.01 34 16053 301 2341697
Diabetes mellitus 123.98 26.01 81 16006 7414 2334584
Chest pain 121.75 26.01 141 15946 27996 2314002
Metabolic acidosis 119.68 26.01 73 16014 5925 2336073
Orthostatic hypotension 119.47 26.01 57 16030 2822 2339176
Device related infection 118.64 26.01 59 16028 3200 2338798
Somnolence 117.56 26.01 127 15960 23358 2318640
Squamous cell carcinoma of skin 117.18 26.01 39 16048 732 2341266
Infusion related reaction 115.49 26.01 86 16001 9710 2332288
Peripheral swelling 115.16 26.01 110 15977 17487 2324511
Cushingoid 113.62 26.01 36 16051 574 2341424
Cellulitis 113.47 26.01 83 16004 9118 2332880
Pain in extremity 112.12 26.01 167 15920 42373 2299625
Respiratory distress 111.59 26.01 66 16021 5063 2336935
Epstein-Barr virus infection 110.54 26.01 41 16046 1070 2340928
Lethargy 110.49 26.01 80 16007 8650 2333348
Abdominal distension 108.65 26.01 85 16002 10326 2331672
Cholestasis 108.44 26.01 58 16029 3663 2338335
Oedema 107.99 26.01 84 16003 10119 2331879
Shock 107.20 26.01 59 16028 3945 2338053
Thrombosis 107.17 26.01 80 16007 9064 2332934
Bronchopulmonary aspergillosis 107.10 26.01 39 16048 965 2341033
Pancreatitis 106.75 26.01 76 16011 8003 2333995
Escherichia bacteraemia 105.39 26.01 30 16057 324 2341674
Substance-induced psychotic disorder 104.71 26.01 29 16058 281 2341717
Chills 103.24 26.01 98 15989 15454 2326544
Ileus 102.48 26.01 47 16040 2125 2339873
Neoplasm progression 101.38 26.01 60 16027 4608 2337390
Eye pain 101.37 26.01 61 16026 4830 2337168
Fall 100.71 26.01 168 15919 46931 2295067
Mania 100.30 26.01 48 16039 2392 2339606
Brain oedema 99.72 26.01 47 16040 2263 2339735
Pneumonia fungal 98.27 26.01 29 16058 359 2341639
Peritonitis 97.86 26.01 48 16039 2526 2339472
Visual acuity reduced 96.87 26.01 61 16026 5237 2336761
Pain 95.97 26.01 192 15895 61665 2280333
Lung disorder 95.14 26.01 64 16023 6148 2335850
Pathological fracture 94.88 26.01 38 16049 1226 2340772
Intestinal perforation 94.81 26.01 42 16045 1749 2340249
Muscle spasms 94.81 26.01 109 15978 21457 2320541
Hypoaesthesia 93.66 26.01 105 15982 20110 2321888
Therapy partial responder 93.28 26.01 28 16059 369 2341629
Bacterial infection 92.23 26.01 44 16043 2177 2339821
Large intestine perforation 91.49 26.01 37 16050 1225 2340773
Computerised tomogram thorax abnormal 91.32 26.01 23 16064 148 2341850
Cytomegalovirus colitis 91.31 26.01 26 16061 281 2341717
Psychotic disorder 90.92 26.01 56 16031 4623 2337375
Urosepsis 90.75 26.01 42 16045 1939 2340059
Pneumonitis 90.56 26.01 53 16034 3986 2338012
Herpes simplex 90.35 26.01 35 16052 1032 2340966
Gastrointestinal haemorrhage 89.54 26.01 82 16005 12353 2329645
Acute respiratory distress syndrome 89.48 26.01 49 16038 3243 2338755
Blood potassium decreased 89.35 26.01 58 16029 5247 2336751
Diverticular perforation 88.74 26.01 28 16059 440 2341558
Aspartate aminotransferase increased 88.54 26.01 82 16005 12530 2329468
Intraocular pressure increased 88.38 26.01 38 16049 1471 2340527
Toxicity to various agents 88.28 26.01 130 15957 32624 2309374
Pseudomonal sepsis 88.16 26.01 25 16062 266 2341732
Foetal growth restriction 88.10 26.01 35 16052 1105 2340893
Diffuse large B-cell lymphoma recurrent 87.70 26.01 20 16067 78 2341920
Enterocolitis 87.26 26.01 32 16055 808 2341190
Pneumonia cytomegaloviral 87.16 26.01 25 16062 278 2341720
Herpes simplex encephalitis 86.90 26.01 20 16067 82 2341916
Influenza 86.54 26.01 82 16005 12896 2329102
Rectal haemorrhage 86.50 26.01 59 16028 5797 2336201
Lung infiltration 85.41 26.01 42 16045 2222 2339776
Upper respiratory tract infection 85.36 26.01 69 16018 8782 2333216
Cerebral haemorrhage 84.99 26.01 57 16030 5447 2336551
Pancreatitis acute 84.91 26.01 50 16037 3803 2338195
Generalised tonic-clonic seizure 83.83 26.01 56 16031 5316 2336682
Sinusitis 83.76 26.01 90 15997 16436 2325562
Enterococcal bacteraemia 83.67 26.01 21 16066 133 2341865
Corneal oedema 83.46 26.01 25 16062 327 2341671
Lymphocyte count decreased 83.05 26.01 47 16040 3316 2338682
Varicella zoster virus infection 83.04 26.01 25 16062 333 2341665
Acute respiratory failure 81.96 26.01 45 16042 2993 2339005
Staphylococcal infection 81.86 26.01 55 16032 5271 2336727
Purpura 81.75 26.01 38 16049 1772 2340226
Second primary malignancy 81.65 26.01 32 16055 974 2341024
Rash erythematous 80.74 26.01 57 16030 5919 2336079
Oral herpes 80.54 26.01 40 16047 2162 2339836
Cytomegalovirus viraemia 80.18 26.01 26 16061 448 2341550
Visual impairment 79.77 26.01 75 16012 11680 2330318
Encephalopathy 79.61 26.01 51 16036 4510 2337488
Hyperviscosity syndrome 79.54 26.01 17 16070 45 2341953
Melaena 79.41 26.01 49 16038 4057 2337941
Oxygen saturation decreased 79.28 26.01 62 16025 7524 2334474
Cardiotoxicity 78.32 26.01 33 16054 1214 2340784
Oesophagitis 78.03 26.01 38 16049 1968 2340030
Drug reaction with eosinophilia and systemic symptoms 77.74 26.01 54 16033 5464 2336534
Ischaemic stroke 77.27 26.01 45 16042 3352 2338646
Swelling face 77.06 26.01 67 16020 9426 2332572
Uveitis 76.56 26.01 35 16052 1570 2340428
Blood lactate dehydrogenase increased 76.22 26.01 45 16042 3439 2338559
Dysphagia 76.17 26.01 76 16011 12729 2329269
Inappropriate antidiuretic hormone secretion 75.84 26.01 39 16048 2270 2339728
Encephalitis 75.83 26.01 32 16055 1182 2340816
Dysgeusia 75.40 26.01 63 16024 8396 2333602
Ulcerative keratitis 75.38 26.01 26 16061 546 2341452
Abdominal pain upper 74.93 26.01 98 15989 22002 2319996
Hypomagnesaemia 74.80 26.01 40 16047 2524 2339474
Ascites 74.53 26.01 53 16034 5567 2336431
Staphylococcal bacteraemia 73.79 26.01 26 16061 583 2341415
Hepatotoxicity 73.64 26.01 44 16043 3437 2338561
Gastroenteritis 73.51 26.01 42 16045 3018 2338980
Cardiac amyloidosis 73.42 26.01 17 16070 72 2341926
Hepatic function abnormal 72.94 26.01 54 16033 6038 2335960
Blood albumin decreased 72.83 26.01 35 16052 1760 2340238
Gastrointestinal disorder 72.51 26.01 63 16024 8854 2333144
Bradycardia 72.20 26.01 66 16021 9915 2332083
Gastrointestinal fungal infection 71.96 26.01 16 16071 54 2341944
Fungal infection 71.60 26.01 49 16038 4840 2337158
Chest discomfort 71.36 26.01 78 16009 14517 2327481
Acute coronary syndrome 70.89 26.01 33 16054 1544 2340454
Paraesthesia 70.35 26.01 95 15992 21993 2320005
Hyperhidrosis 69.53 26.01 79 16008 15343 2326655
Immunosuppression 69.52 26.01 29 16058 1040 2340958
Fluid overload 68.71 26.01 39 16048 2767 2339231
Perineal necrosis 68.19 26.01 12 16075 4 2341994
Adrenogenital syndrome 68.13 26.01 13 16074 14 2341984
Toxic skin eruption 68.02 26.01 36 16051 2224 2339774
Monoclonal immunoglobulin present 67.82 26.01 17 16070 107 2341891
Aphasia 66.56 26.01 47 16040 4881 2337117
Disorientation 66.41 26.01 52 16035 6320 2335678
Delirium 66.38 26.01 48 16039 5175 2336823
Type 2 diabetes mellitus 66.18 26.01 35 16052 2159 2339839
Ejection fraction decreased 66.09 26.01 38 16049 2763 2339235
Pneumonia pneumococcal 65.91 26.01 20 16067 274 2341724
Cardiac failure congestive 65.11 26.01 78 16009 16023 2325975
Diabetic ketoacidosis 65.06 26.01 41 16046 3523 2338475
Corneal disorder 64.96 26.01 21 16066 358 2341640
Enterococcal infection 64.89 26.01 25 16062 726 2341272
Haemorrhage 64.70 26.01 65 16022 10974 2331024
Enterococcal sepsis 64.05 26.01 17 16070 138 2341860
Diverticulitis 63.98 26.01 43 16044 4122 2337876
Hodgkin's disease 63.97 26.01 23 16064 548 2341450
Pseudomonas infection 63.83 26.01 28 16059 1138 2340860
Hemiparesis 63.76 26.01 40 16047 3410 2338588
Bacterial sepsis 63.61 26.01 22 16065 466 2341532
Ileus paralytic 63.47 26.01 25 16062 771 2341227
Cardiomyopathy 63.36 26.01 37 16050 2770 2339228
Eye irritation 63.10 26.01 40 16047 3472 2338526
Mucormycosis 63.09 26.01 21 16066 394 2341604
Hepatic failure 62.71 26.01 48 16039 5641 2336357
Neoplasm recurrence 62.60 26.01 21 16066 404 2341594
Skin ulcer 62.58 26.01 42 16045 4017 2337981
Pulmonary haemorrhage 62.51 26.01 28 16059 1197 2340801
Depressed level of consciousness 62.38 26.01 54 16033 7550 2334448
Anaphylactic reaction 62.18 26.01 60 16027 9645 2332353
Fluid retention 61.81 26.01 52 16035 6994 2335004
Cerebral infarction 61.51 26.01 43 16044 4394 2337604
Ear pain 61.43 26.01 36 16051 2713 2339285
Agitation 61.00 26.01 63 16024 10988 2331010
Cytomegalovirus chorioretinitis 60.89 26.01 17 16070 170 2341828
Embolism 60.65 26.01 28 16059 1285 2340713
Drug resistance 60.32 26.01 35 16052 2589 2339409
Skin striae 60.27 26.01 17 16070 177 2341821
Perineal infection 60.27 26.01 12 16075 19 2341979
Haematocrit decreased 60.22 26.01 42 16045 4276 2337722
Ocular hyperaemia 60.22 26.01 41 16046 4015 2337983
Escherichia infection 59.94 26.01 28 16059 1320 2340678
Liver disorder 59.72 26.01 49 16038 6365 2335633
Venous thrombosis limb 59.63 26.01 21 16066 470 2341528
Klebsiella infection 59.38 26.01 24 16063 793 2341205
Hyperkalaemia 59.06 26.01 47 16040 5846 2336152
Palmar-plantar erythrodysaesthesia syndrome 58.91 26.01 41 16046 4160 2337838
Pseudomonas test positive 58.72 26.01 16 16071 145 2341853
Brain abscess 58.34 26.01 19 16068 332 2341666
Pruritus 57.17 26.01 126 15961 43214 2298784
Thrombotic microangiopathy 56.88 26.01 27 16060 1320 2340678
Blood alkaline phosphatase increased 56.79 26.01 48 16039 6497 2335501
Productive cough 56.70 26.01 44 16043 5277 2336721
Blood bilirubin increased 56.52 26.01 44 16043 5301 2336697
Meningoencephalitis herpetic 56.49 26.01 17 16070 226 2341772
Large intestinal ulcer perforation 56.34 26.01 10 16077 4 2341994
Rectal adenocarcinoma 56.28 26.01 14 16073 85 2341913
Strongyloidiasis 56.02 26.01 16 16071 175 2341823
Skin lesion 55.78 26.01 39 16048 3986 2338012
Peripheral motor neuropathy 55.55 26.01 17 16070 240 2341758
Neuralgia 55.39 26.01 34 16053 2788 2339210
Hallucination 55.29 26.01 52 16035 8096 2333902
Interstitial lung disease 55.21 26.01 51 16036 7761 2334237
Urinary tract infection bacterial 55.06 26.01 20 16067 491 2341507
Drug intolerance 54.72 26.01 66 16021 13651 2328347
Balance disorder 54.57 26.01 56 16031 9691 2332307
Arthralgia 54.56 26.01 142 15945 54143 2287855
Toxic epidermal necrolysis 54.48 26.01 35 16052 3109 2338889
Acute myocardial infarction 54.29 26.01 42 16045 5013 2336985
Status epilepticus 54.18 26.01 32 16055 2446 2339552
Cognitive disorder 54.11 26.01 43 16044 5338 2336660
Appendicitis 53.93 26.01 25 16062 1158 2340840
Photophobia 53.86 26.01 31 16056 2258 2339740
Pneumonia influenzal 53.55 26.01 15 16072 152 2341846
Breast cancer metastatic 53.03 26.01 30 16057 2114 2339884
Salmonella sepsis 52.99 26.01 12 16075 45 2341953
Failure to thrive 52.80 26.01 23 16064 919 2341079
Human bocavirus infection 52.78 26.01 10 16077 10 2341988
Mesenteric abscess 52.78 26.01 10 16077 10 2341988
Clostridium test positive 52.58 26.01 17 16070 290 2341708
Product packaging confusion 52.58 26.01 12 16075 47 2341951
Acidosis 52.32 26.01 27 16060 1583 2340415
Aplasia 52.25 26.01 19 16068 468 2341530
Progressive multifocal leukoencephalopathy 52.16 26.01 30 16057 2182 2339816
Escherichia urinary tract infection 51.98 26.01 25 16062 1259 2340739
Coagulopathy 51.93 26.01 33 16054 2876 2339122
Lung adenocarcinoma 51.89 26.01 21 16066 696 2341302
Stress cardiomyopathy 51.84 26.01 26 16061 1435 2340563
Adenocarcinoma of colon 51.68 26.01 17 16070 307 2341691
Anxiety 51.37 26.01 96 15991 29263 2312735
Pulmonary mycosis 51.27 26.01 14 16073 128 2341870
Hypertrophic cardiomyopathy 51.27 26.01 16 16071 242 2341756
Tooth erosion 50.98 26.01 14 16073 131 2341867
Clostridium bacteraemia 50.96 26.01 11 16076 31 2341967
Nasal abscess 50.96 26.01 11 16076 31 2341967
Post transplant lymphoproliferative disorder 50.85 26.01 19 16068 506 2341492
Bronchospasm 50.76 26.01 33 16054 2991 2339007
Oliguria 50.66 26.01 25 16062 1332 2340666
Psychomotor hyperactivity 50.55 26.01 28 16059 1894 2340104
Spinal fracture 50.38 26.01 32 16055 2787 2339211
Enterobacter infection 50.32 26.01 16 16071 258 2341740
Metastases to central nervous system 50.30 26.01 29 16058 2119 2339879
Blood calcium decreased 50.17 26.01 29 16058 2129 2339869
Cryptococcosis 50.15 26.01 14 16073 140 2341858
Streptococcal bacteraemia 50.06 26.01 14 16073 141 2341857
Hepatitis B reactivation 49.98 26.01 16 16071 264 2341734
Cerebral aspergillosis 49.87 26.01 12 16075 62 2341936
Generalised oedema 49.85 26.01 30 16057 2373 2339625
Sinus polyp 49.71 26.01 12 16075 63 2341935
Febrile infection 49.67 26.01 15 16072 202 2341796
Respiratory syncytial virus infection 49.62 26.01 20 16067 656 2341342
Oral disorder 49.57 26.01 25 16062 1396 2340602
Bone lesion 49.53 26.01 20 16067 659 2341339
Leukoencephalopathy 49.50 26.01 21 16066 786 2341212
Electrocardiogram QT prolonged 49.47 26.01 48 16039 7766 2334232
Hyperlipidaemia 49.40 26.01 31 16056 2643 2339355
Circulatory collapse 49.13 26.01 35 16052 3685 2338313
Haemoglobin abnormal 49.08 26.01 20 16067 675 2341323
Epistaxis 49.07 26.01 53 16034 9726 2332272
Low birth weight baby 48.95 26.01 21 16066 808 2341190
Hepatic steatosis 48.94 26.01 33 16054 3180 2338818
Non-cardiac chest pain 48.93 26.01 21 16066 809 2341189
Pneumonia bacterial 48.90 26.01 22 16065 950 2341048
Coma 48.84 26.01 51 16036 9005 2332993
Keratitis fungal 48.73 26.01 10 16077 20 2341978
Neutropenic colitis 48.69 26.01 16 16071 288 2341710
Intraductal proliferative breast lesion 48.67 26.01 17 16070 371 2341627
Rhinovirus infection 48.33 26.01 16 16071 295 2341703
Dry skin 48.12 26.01 44 16043 6608 2335390
Leukocytosis 48.05 26.01 34 16053 3542 2338456
Alopecia 47.63 26.01 79 16008 21922 2320076
Oral pain 47.27 26.01 33 16054 3364 2338634
Recurrent cancer 47.11 26.01 16 16071 320 2341678
Transaminases increased 46.86 26.01 37 16050 4550 2337448
Chorioretinopathy 46.83 26.01 15 16072 248 2341750
Troponin increased 46.80 26.01 22 16065 1052 2340946
Malnutrition 46.69 26.01 26 16061 1777 2340221
Tachypnoea 46.69 26.01 28 16059 2201 2339797
Thrombophlebitis 46.63 26.01 20 16067 769 2341229
Respiratory depth decreased 46.56 26.01 9 16078 11 2341987
Colitis ischaemic 46.24 26.01 25 16062 1612 2340386
Gait disturbance 46.21 26.01 79 16008 22466 2319532
Glioblastoma multiforme 46.19 26.01 14 16073 191 2341807
Amyloidosis 46.01 26.01 15 16072 263 2341735
Sudden death 45.93 26.01 26 16061 1834 2340164
Dysphonia 45.85 26.01 42 16045 6322 2335676
Metabolic encephalopathy 45.76 26.01 18 16069 553 2341445
Pneumothorax 45.74 26.01 28 16059 2284 2339714
Dyspnoea exertional 45.66 26.01 40 16047 5680 2336318
Pneumonia pseudomonal 45.64 26.01 15 16072 270 2341728
Refractory cytopenia with multilineage dysplasia 45.62 26.01 10 16077 31 2341967
Hepatitis B 45.43 26.01 20 16067 820 2341178
Candida sepsis 45.36 26.01 13 16074 144 2341854
Meningitis cryptococcal 45.21 26.01 14 16073 206 2341792
Treatment failure 44.95 26.01 44 16043 7195 2334803
Stevens-Johnson syndrome 44.90 26.01 35 16052 4224 2337774
Hypoalbuminaemia 44.21 26.01 23 16064 1371 2340627
Pulpitis dental 44.19 26.01 13 16074 159 2341839
Atrial flutter 44.19 26.01 22 16065 1195 2340803
Myocarditis 44.08 26.01 22 16065 1201 2340797
Subdural haematoma 43.92 26.01 27 16060 2219 2339779
Lymphadenopathy 43.80 26.01 39 16048 5659 2336339
Phaeochromocytoma crisis 43.65 26.01 10 16077 40 2341958
Feeling abnormal 43.63 26.01 79 16008 23502 2318496
Pneumatosis intestinalis 43.51 26.01 16 16071 407 2341591
Speech disorder 43.37 26.01 41 16046 6423 2335575
Light chain analysis increased 43.35 26.01 12 16075 116 2341882
Osteonecrosis of jaw 43.07 26.01 45 16042 7951 2334047
Myalgia 42.95 26.01 78 16009 23255 2318743
Toxic encephalopathy 42.70 26.01 19 16068 799 2341199
Red blood cell count decreased 42.69 26.01 34 16053 4232 2337766
Venous thrombosis 42.64 26.01 19 16068 802 2341196
Nephrocalcinosis 42.58 26.01 13 16074 182 2341816
Soft tissue infection 42.41 26.01 15 16072 340 2341658
Pericardial effusion 42.38 26.01 33 16054 3976 2338022
Escherichia sepsis 42.36 26.01 17 16070 551 2341447
Haematuria 42.33 26.01 34 16053 4284 2337714
Birdshot chorioretinopathy 42.22 26.01 8 16079 8 2341990
Hepatitis 42.14 26.01 40 16047 6297 2335701
Dyspepsia 41.95 26.01 49 16038 9795 2332203
Polyuria 41.83 26.01 21 16066 1161 2340837
Mitochondrial DNULL mutation 41.74 26.01 8 16079 9 2341989
Cerebral ischaemia 41.70 26.01 21 16066 1169 2340829
Kaposi's sarcoma 41.51 26.01 14 16073 274 2341724
Epstein-Barr virus associated lymphoproliferative disorder 41.51 26.01 14 16073 274 2341724
Trichodysplasia spinulosa 41.51 26.01 10 16077 52 2341946
Superficial spreading melanoma stage unspecified 41.51 26.01 10 16077 52 2341946
Cardio-respiratory arrest 41.46 26.01 47 16040 9099 2332899
Ataxia 41.35 26.01 27 16060 2465 2339533
Hypogammaglobulinaemia 41.25 26.01 18 16069 722 2341276
Hemiplegia 41.20 26.01 22 16065 1383 2340615
Chronic myelomonocytic leukaemia 41.15 26.01 11 16076 92 2341906
Hypertensive crisis 41.14 26.01 27 16060 2486 2339512
Corneal perforation 40.94 26.01 11 16076 94 2341904
Peripheral sensorimotor neuropathy 40.92 26.01 12 16075 145 2341853
Endocarditis 40.77 26.01 18 16069 743 2341255
Flushing 40.76 26.01 53 16034 11818 2330180
Listeriosis 40.75 26.01 13 16074 212 2341786
Spinal compression fracture 40.72 26.01 24 16063 1827 2340171
Increased appetite 40.70 26.01 22 16065 1418 2340580
Punctate keratitis 40.48 26.01 12 16075 151 2341847
Invasive ductal breast carcinoma 40.45 26.01 19 16068 907 2341091
Nervous system disorder 40.42 26.01 29 16058 3087 2338911
Antithrombin III decreased 40.30 26.01 10 16077 60 2341938
Respiratory disorder 40.26 26.01 32 16055 3972 2338026
Propofol infusion syndrome 40.05 26.01 11 16076 103 2341895
Arrhythmia 39.99 26.01 38 16049 5990 2336008
Viral infection 39.96 26.01 34 16053 4642 2337356
Mucosal erosion 39.82 26.01 13 16074 229 2341769
Feeling jittery 39.77 26.01 24 16063 1908 2340090
Humerus fracture 39.68 26.01 20 16067 1115 2340883
Periodontitis 39.55 26.01 17 16070 657 2341341
Mucocutaneous ulceration 39.48 26.01 9 16078 35 2341963
Blood pressure increased 39.48 26.01 63 16024 16923 2325075
Cholecystitis acute 39.47 26.01 20 16067 1128 2340870
Chronic kidney disease 39.47 26.01 32 16055 4086 2337912
Abnormal behaviour 39.43 26.01 34 16053 4726 2337272
Blood pressure decreased 39.40 26.01 46 16041 9190 2332808
Small intestinal obstruction 39.17 26.01 25 16062 2195 2339803
Vitritis 39.04 26.01 12 16075 172 2341826
Fungaemia 38.95 26.01 13 16074 246 2341752
Drug hypersensitivity 38.88 26.01 114 15973 46529 2295469
Gastrointestinal toxicity 38.45 26.01 16 16071 570 2341428
Laboratory test abnormal 38.28 26.01 35 16052 5255 2336743
Pneumonia viral 38.19 26.01 15 16072 459 2341539
Transverse sinus thrombosis 38.13 26.01 11 16076 125 2341873
Klebsiella bacteraemia 38.13 26.01 11 16076 125 2341873
Spinal cord compression 38.09 26.01 16 16071 584 2341414
Conjunctival hyperaemia 38.01 26.01 16 16071 587 2341411
Autonomic neuropathy 37.89 26.01 11 16076 128 2341870
Acute sinusitis 37.89 26.01 15 16072 469 2341529
Therapeutic response decreased 37.87 26.01 40 16047 7155 2334843
Muscle atrophy 37.67 26.01 19 16068 1061 2340937
Escherichia test positive 37.64 26.01 13 16074 274 2341724
Stem cell transplant 37.64 26.01 14 16073 368 2341630
Corneal opacity 37.48 26.01 12 16075 198 2341800
Secondary immunodeficiency 37.48 26.01 10 16077 83 2341915
Loss of consciousness 37.45 26.01 65 16022 18702 2323296
Refractory anaemia with an excess of blasts 37.37 26.01 10 16077 84 2341914
Iris adhesions 37.27 26.01 10 16077 85 2341913
Quadriplegia 37.22 26.01 14 16073 380 2341618
Inflammation 37.16 26.01 37 16050 6176 2335822
Altered state of consciousness 37.00 26.01 30 16057 3830 2338168
Potentiating drug interaction 36.80 26.01 16 16071 636 2341362
Unresponsive to stimuli 36.73 26.01 33 16054 4843 2337155
Ingrowing nail 36.66 26.01 13 16074 297 2341701
Jugular vein thrombosis 36.64 26.01 14 16073 397 2341601
Asthma 36.51 26.01 49 16038 11265 2330733
Fungal skin infection 36.46 26.01 15 16072 519 2341479
Stridor 36.36 26.01 16 16071 655 2341343
Oral fungal infection 36.25 26.01 14 16073 409 2341589
Urinary retention 36.21 26.01 29 16058 3638 2338360
Epstein Barr virus positive mucocutaneous ulcer 36.13 26.01 9 16078 55 2341943
Hyperammonaemia 36.12 26.01 17 16070 815 2341183
Parainfluenzae virus infection 36.09 26.01 11 16076 153 2341845
Blood sodium decreased 36.03 26.01 27 16060 3073 2338925
Ureaplasma infection 35.98 26.01 8 16079 27 2341971
Heart rate increased 35.69 26.01 48 16039 11057 2330941
Duodenal ulcer perforation 35.68 26.01 13 16074 322 2341676
Hypopyon 35.64 26.01 11 16076 160 2341838
Vertigo 35.55 26.01 44 16043 9340 2332658
Phaeochromocytoma 35.45 26.01 11 16076 163 2341835
Osteolysis 35.38 26.01 14 16073 437 2341561
Pulmonary hypertension 35.36 26.01 33 16054 5085 2336913
Phlebitis 35.30 26.01 18 16069 1029 2340969
Left ventricular dysfunction 35.20 26.01 19 16068 1221 2340777
Hodgkin's disease refractory 35.19 26.01 7 16080 11 2341987
Gastroenteritis norovirus 35.10 26.01 12 16075 245 2341753
Atypical pneumonia 35.01 26.01 15 16072 575 2341423
Abscess limb 35.01 26.01 15 16072 575 2341423
Lipase increased 34.93 26.01 20 16067 1442 2340556
Gamma-glutamyltransferase increased 34.89 26.01 34 16053 5528 2336470
Gastrointestinal perforation 34.84 26.01 16 16071 725 2341273
Superior sagittal sinus thrombosis 34.62 26.01 11 16076 177 2341821
Mouth ulceration 34.57 26.01 29 16058 3883 2338115
Epilepsy 34.17 26.01 31 16056 4608 2337390
Supraventricular tachycardia 33.90 26.01 22 16065 1987 2340011
Myocardial ischaemia 33.89 26.01 23 16064 2239 2339759
Graft versus host disease 33.83 26.01 17 16070 942 2341056
Ocular hypertension 33.63 26.01 11 16076 195 2341803
Osteomyelitis bacterial 33.46 26.01 8 16079 40 2341958
Pneumonia streptococcal 33.42 26.01 11 16076 199 2341799
Clostridium difficile infection 33.20 26.01 25 16062 2865 2339133
Glaucoma 33.06 26.01 22 16065 2073 2339925
Purpura senile 32.90 26.01 7 16080 18 2341980
Adenocarcinoma pancreas 32.82 26.01 11 16076 211 2341787
Fusarium infection 32.60 26.01 9 16078 86 2341912
Streptococcal infection 32.45 26.01 16 16071 851 2341147
Skin infection 32.42 26.01 19 16068 1431 2340567
Diffuse large B-cell lymphoma 32.39 26.01 16 16071 854 2341144
Prothrombin time prolonged 32.39 26.01 20 16067 1657 2340341
Vascular pain 32.37 26.01 10 16077 146 2341852
Face oedema 32.30 26.01 28 16059 3920 2338078
Cerebral venous thrombosis 32.29 26.01 13 16074 425 2341573
White blood cell count abnormal 32.25 26.01 15 16072 700 2341298
Sinus tachycardia 32.21 26.01 26 16061 3299 2338699
Renal vein thrombosis 32.15 26.01 9 16078 91 2341907
Neutrophil count abnormal 32.03 26.01 13 16074 434 2341564
Virilism 31.86 26.01 7 16080 22 2341976
Gastrooesophageal reflux disease 31.84 26.01 41 16046 9054 2332944
Pneumonia aspiration 31.55 26.01 27 16060 3715 2338283
Opportunistic infection 31.43 26.01 13 16074 456 2341542
Meningitis streptococcal 31.40 26.01 7 16080 24 2341974
Epstein-Barr virus associated lymphoma 31.30 26.01 8 16079 55 2341943
Pancreatitis necrotising 31.24 26.01 11 16076 246 2341752
Listeria encephalitis 31.18 26.01 7 16080 25 2341973
Presyncope 31.17 26.01 27 16060 3776 2338222
Anaphylactoid shock 31.14 26.01 9 16078 103 2341895
Eyelid ptosis 31.09 26.01 17 16070 1121 2340877
Staphylococcus test positive 31.03 26.01 13 16074 471 2341527
Hepatomegaly 31.00 26.01 20 16067 1789 2340209
Bronchiectasis 30.89 26.01 16 16071 945 2341053
Gene mutation 30.85 26.01 10 16077 172 2341826
Pseudomonal bacteraemia 30.82 26.01 9 16078 107 2341891
Irritability 30.79 26.01 34 16053 6393 2335605
Sensory disturbance 30.75 26.01 23 16064 2609 2339389
Infusion site streaking 30.74 26.01 6 16081 8 2341990
Diarrhoea haemorrhagic 30.72 26.01 18 16069 1355 2340643
Choroiditis 30.70 26.01 8 16079 60 2341938
Cerebral artery thrombosis 30.67 26.01 9 16078 109 2341889
Human herpesvirus 6 infection 30.53 26.01 12 16075 368 2341630
Cerebral venous sinus thrombosis 30.43 26.01 12 16075 371 2341627
Pleuritic pain 30.43 26.01 14 16073 637 2341361
Vaginal haemorrhage 30.41 26.01 30 16057 4950 2337048
Blood urea increased 30.37 26.01 26 16061 3579 2338419
Corneal infiltrates 30.35 26.01 8 16079 63 2341935
Guillain-Barre syndrome 30.29 26.01 14 16073 644 2341354
Palpitations 30.26 26.01 55 16032 16401 2325597
Pneumonia klebsiella 30.09 26.01 11 16076 275 2341723
Periorbital oedema 30.02 26.01 16 16071 1002 2340996
Breakthrough pain 29.97 26.01 10 16077 189 2341809
Hyponatraemic seizure 29.92 26.01 8 16079 67 2341931
Peritonitis viral 29.85 26.01 5 16082 0 2341998
Bowen's disease 29.78 26.01 10 16077 193 2341805
Mantle cell lymphoma 29.61 26.01 9 16078 124 2341874
Dysarthria 29.61 26.01 33 16054 6269 2335729
Invasive lobular breast carcinoma 29.48 26.01 9 16078 126 2341872
Emphysematous cystitis 29.45 26.01 7 16080 34 2341964
Eye pruritus 29.31 26.01 22 16065 2509 2339489
Protein total increased 29.31 26.01 12 16075 410 2341588
Intussusception 29.28 26.01 9 16078 129 2341869
Lacrimation increased 29.27 26.01 23 16064 2807 2339191
Gastric haemorrhage 29.23 26.01 16 16071 1057 2340941
Tarsal tunnel syndrome 29.12 26.01 7 16080 36 2341962
Meningitis 29.10 26.01 16 16071 1066 2340932
Eating disorder 29.06 26.01 21 16066 2260 2339738
Enteritis 29.05 26.01 16 16071 1070 2340928
Neonatal respiratory distress syndrome 29.03 26.01 13 16074 555 2341443
Philadelphia chromosome positive 28.96 26.01 7 16080 37 2341961
Inhibiting antibodies positive 28.94 26.01 5 16082 1 2341997
Rash macular 28.80 26.01 25 16062 3506 2338492
Nail infection 28.77 26.01 10 16077 215 2341783
Vasculitis 28.76 26.01 21 16066 2297 2339701
Memory impairment 28.75 26.01 47 16040 12876 2329122
Visceral leishmaniasis 28.74 26.01 8 16079 79 2341919
Full blood count decreased 28.42 26.01 25 16062 3568 2338430
Skin exfoliation 28.38 26.01 31 16056 5759 2336239
Adenovirus infection 28.34 26.01 11 16076 326 2341672
VIth nerve paresis 28.32 26.01 6 16081 15 2341983
Hyperuricaemia 28.23 26.01 13 16074 593 2341405
Cardiomegaly 28.14 26.01 21 16066 2375 2339623
White blood cell count increased 28.12 26.01 34 16053 7044 2334954
Periorbital cellulitis 28.05 26.01 8 16079 87 2341911
Hypoglossal nerve paresis 28.04 26.01 6 16081 16 2341982
Hypoglycaemia 28.03 26.01 37 16050 8370 2333628
Bronchitis viral 27.92 26.01 9 16078 152 2341846
Campylobacter infection 27.88 26.01 8 16079 89 2341909
Diabetes mellitus inadequate control 27.83 26.01 19 16068 1868 2340130
Haemodynamic instability 27.82 26.01 16 16071 1163 2340835
Nasopharyngitis 27.78 26.01 63 16024 21993 2320005
Postictal state 27.74 26.01 10 16077 240 2341758
Adrenal suppression 27.65 26.01 9 16078 157 2341841
Learning disability 27.53 26.01 7 16080 47 2341951
Enterovirus test positive 27.52 26.01 6 16081 18 2341980
Eye inflammation 27.46 26.01 14 16073 800 2341198
Osteopenia 27.39 26.01 19 16068 1916 2340082
Protein total decreased 27.20 26.01 14 16073 816 2341182
Fungal oesophagitis 27.18 26.01 8 16079 98 2341900
Hyperglycaemic hyperosmolar nonketotic syndrome 27.11 26.01 8 16079 99 2341899
Adenoviral haemorrhagic cystitis 27.04 26.01 6 16081 20 2341978
Infusion site vesicles 27.04 26.01 7 16080 51 2341947
Pneumonia staphylococcal 27.00 26.01 11 16076 371 2341627
Serum ferritin increased 26.93 26.01 14 16073 833 2341165
Gastritis 26.87 26.01 27 16060 4554 2337444
Product packaging quantity issue 26.78 26.01 11 16076 379 2341619
Graft versus host disease in skin 26.77 26.01 10 16077 266 2341732
Swelling 26.77 26.01 52 16035 16298 2325700
Oesophageal candidiasis 26.76 26.01 13 16074 669 2341329
Rosacea 26.76 26.01 12 16075 514 2341484
Hepatic infarction 26.75 26.01 8 16079 104 2341894
Neutrophilia 26.74 26.01 12 16075 515 2341483
Lung consolidation 26.67 26.01 12 16075 518 2341480
Human rhinovirus test positive 26.60 26.01 6 16081 22 2341976
Depression 26.60 26.01 72 16015 28060 2313938
Chronic obstructive pulmonary disease 26.51 26.01 33 16054 7044 2334954
Anal incontinence 26.51 26.01 18 16069 1754 2340244
Heart block congenital 26.39 26.01 5 16082 5 2341993
Femoral neck fracture 26.38 26.01 16 16071 1283 2340715
Dry eye 26.36 26.01 25 16062 3931 2338067
Acute hepatic failure 26.31 26.01 21 16066 2621 2339377
Haemodialysis 26.25 26.01 19 16068 2050 2339948
Rash pustular 26.05 26.01 17 16070 1550 2340448
Infection reactivation 26.01 26.01 8 16079 115 2341883

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia 2920.51 27.17 1514 18385 44668 1682214
Plasma cell myeloma 2563.81 27.17 891 19008 9123 1717759
Thrombocytopenia 2011.61 27.17 922 18977 20327 1706555
Neutropenia 1994.71 27.17 876 19023 17384 1709498
Febrile neutropenia 1868.09 27.17 726 19173 10374 1716508
Pyrexia 1539.01 27.17 1005 18894 45395 1681487
Sepsis 1316.87 27.17 672 19227 18766 1708116
Neuropathy peripheral 1104.72 27.17 474 19425 8779 1718103
Anaemia 1058.69 27.17 673 19226 28784 1698098
Off label use 1035.74 27.17 735 19164 37836 1689046
Septic shock 1006.05 27.17 427 19472 7682 1719200
Diarrhoea 836.87 27.17 744 19155 53108 1673774
Pancytopenia 814.84 27.17 409 19490 10948 1715934
Fatigue 714.40 27.17 664 19235 50117 1676765
Hyperglycaemia 666.58 27.17 280 19619 4885 1721997
Acute kidney injury 653.79 27.17 538 19361 34406 1692476
Respiratory failure 625.03 27.17 373 19526 14132 1712750
Platelet count decreased 600.18 27.17 381 19518 16142 1710740
Pulmonary embolism 597.10 27.17 349 19550 12710 1714172
Deep vein thrombosis 581.03 27.17 312 19587 9608 1717274
Disease progression 570.19 27.17 375 19524 16888 1709994
Neutropenic sepsis 552.05 27.17 176 19723 1316 1725566
Dyspnoea 548.26 27.17 582 19317 51477 1675405
Drug ineffective 538.09 27.17 635 19264 63166 1663716
Myelodysplastic syndrome 536.35 27.17 211 19688 3078 1723804
Product use in unapproved indication 534.03 27.17 290 19609 9132 1717750
Leukopenia 531.19 27.17 279 19620 8201 1718681
Multiple organ dysfunction syndrome 516.95 27.17 282 19617 8960 1717922
Constipation 502.82 27.17 329 19570 14671 1712211
Atrial fibrillation 495.73 27.17 327 19572 14784 1712098
Pneumocystis jirovecii pneumonia 488.03 27.17 182 19717 2274 1724608
Infection 483.66 27.17 299 19600 12061 1714821
Asthenia 483.37 27.17 452 19447 34218 1692664
Febrile bone marrow aplasia 476.19 27.17 139 19760 739 1726143
Lower respiratory tract infection 460.88 27.17 198 19701 3653 1723229
Renal failure 452.35 27.17 345 19554 19672 1707210
Dehydration 424.74 27.17 316 19583 17342 1709540
Tumour lysis syndrome 419.53 27.17 149 19750 1602 1725280
Plasma cell myeloma recurrent 406.16 27.17 108 19791 378 1726504
Malignant neoplasm progression 398.97 27.17 279 19620 13879 1713003
Hypotension 388.85 27.17 374 19525 29280 1697602
Neutrophil count decreased 383.21 27.17 201 19698 5880 1721002
Venoocclusive liver disease 382.25 27.17 119 19780 814 1726068
White blood cell count decreased 351.58 27.17 251 19648 12898 1713984
Nausea 343.02 27.17 455 19444 50741 1676141
Vomiting 339.36 27.17 392 19507 37923 1688959
General physical health deterioration 338.33 27.17 245 19654 12873 1714009
Confusional state 328.21 27.17 294 19605 20984 1705898
Squamous cell carcinoma of skin 325.47 27.17 113 19786 1129 1725753
Bacteraemia 321.83 27.17 125 19774 1755 1725127
Acute myeloid leukaemia 320.40 27.17 143 19756 2898 1723984
Cytomegalovirus infection 318.56 27.17 146 19753 3155 1723727
Pleural effusion 317.64 27.17 221 19678 10889 1715993
Cytomegalovirus chorioretinitis 307.90 27.17 83 19816 310 1726572
Posterior reversible encephalopathy syndrome 302.80 27.17 112 19787 1363 1725519
Bone marrow failure 299.70 27.17 162 19737 5038 1721844
Osteonecrosis 293.18 27.17 146 19753 3816 1723066
Cardiac failure 292.63 27.17 221 19678 12381 1714501
Strongyloidiasis 291.30 27.17 81 19818 349 1726533
Hypofibrinogenaemia 288.76 27.17 70 19829 148 1726734
Mucosal inflammation 283.23 27.17 145 19754 4024 1722858
Plasmacytoma 282.22 27.17 82 19817 427 1726455
Back pain 268.86 27.17 236 19663 16377 1710505
Insomnia 264.96 27.17 232 19667 16044 1710838
Condition aggravated 264.14 27.17 260 19639 20890 1705992
Cytopenia 260.13 27.17 89 19810 847 1726035
Hypertriglyceridaemia 259.97 27.17 95 19804 1114 1725768
Basal cell carcinoma 259.11 27.17 116 19783 2367 1724515
Abdominal pain 258.79 27.17 259 19640 21231 1705651
Respiratory tract infection 258.66 27.17 116 19783 2377 1724505
Acute lymphocytic leukaemia recurrent 256.55 27.17 68 19831 234 1726648
Haemophagocytic lymphohistiocytosis 253.16 27.17 98 19801 1362 1725520
Syncope 240.74 27.17 207 19692 13962 1712920
Diabetes mellitus 234.63 27.17 153 19746 6755 1720127
Oedema peripheral 226.06 27.17 208 19691 15342 1711540
Muscular weakness 225.21 27.17 174 19725 10075 1716807
Decreased appetite 220.60 27.17 250 19649 23621 1703261
Hyperbilirubinaemia 220.13 27.17 101 19798 2186 1724696
Lymphopenia 218.59 27.17 97 19802 1936 1724946
Renal impairment 215.46 27.17 183 19716 12131 1714751
Haemoglobin decreased 214.69 27.17 211 19688 16903 1709979
Polyneuropathy 212.33 27.17 91 19808 1664 1725218
Bronchopulmonary aspergillosis 212.15 27.17 88 19811 1478 1725404
Hypoxia 209.68 27.17 135 19764 5828 1721054
Influenza 203.59 27.17 139 19760 6628 1720254
Hypercalcaemia 202.81 27.17 90 19809 1796 1725086
Hypertension 200.92 27.17 216 19683 19232 1707650
Colitis 196.60 27.17 114 19785 4066 1722816
Cellulitis 192.54 27.17 132 19767 6336 1720546
Mucormycosis 191.96 27.17 67 19832 680 1726202
Hyponatraemia 187.31 27.17 148 19751 8852 1718030
Blood glucose increased 186.57 27.17 158 19741 10426 1716456
Haematotoxicity 182.92 27.17 69 19830 889 1725993
Adenocarcinoma of colon 173.91 27.17 55 19844 398 1726484
Weight increased 172.95 27.17 156 19743 11201 1715681
Rash 171.83 27.17 284 19615 38409 1688473
Hiccups 170.19 27.17 74 19825 1403 1725479
Device related infection 168.33 27.17 84 19815 2202 1724680
Endophthalmitis 167.91 27.17 60 19839 656 1726226
Bronchitis 164.36 27.17 112 19787 5320 1721562
Urinary tract infection 163.60 27.17 144 19755 10009 1716873
Prostate cancer 163.27 27.17 105 19794 4521 1722361
Adrenal insufficiency 162.55 27.17 70 19829 1295 1725587
Alanine aminotransferase increased 162.55 27.17 156 19743 12122 1714760
Fall 159.11 27.17 227 19672 26987 1699895
Cough 158.74 27.17 190 19709 19007 1707875
Aspergillus infection 155.63 27.17 68 19831 1305 1725577
Stomatitis 155.43 27.17 108 19791 5296 1721586
Chills 153.78 27.17 148 19751 11539 1715343
Infusion related reaction 151.48 27.17 115 19784 6478 1720404
Hypocalcaemia 150.86 27.17 87 19812 3069 1723813
Plasma cell leukaemia 148.22 27.17 40 19859 150 1726732
Hypokalaemia 146.04 27.17 111 19788 6263 1720619
Intraocular pressure increased 145.36 27.17 62 19837 1119 1725763
Herpes zoster 144.82 27.17 97 19802 4476 1722406
Cardiac arrest 143.87 27.17 165 19734 15765 1711117
Diverticular perforation 142.62 27.17 48 19851 432 1726450
Blood creatinine increased 142.35 27.17 154 19745 13792 1713090
Acute respiratory distress syndrome 141.35 27.17 87 19812 3464 1723418
Escherichia sepsis 139.51 27.17 51 19848 598 1726284
Cushing's syndrome 139.32 27.17 50 19849 554 1726328
Pneumonitis 138.49 27.17 89 19810 3826 1723056
Pseudomonas infection 136.25 27.17 61 19838 1243 1725639
Epistaxis 136.18 27.17 119 19780 8187 1718695
Cushingoid 135.94 27.17 44 19855 346 1726536
Peripheral sensory neuropathy 135.88 27.17 54 19845 807 1726075
Staphylococcal infection 130.52 27.17 92 19807 4615 1722267
Enterococcal infection 130.07 27.17 53 19846 848 1726034
Respiratory distress 129.73 27.17 95 19804 5062 1721820
Headache 126.01 27.17 232 19667 34144 1692738
Lung disorder 125.84 27.17 93 19806 5026 1721856
Second primary malignancy 125.08 27.17 54 19845 1005 1725877
Acute lymphocytic leukaemia 124.07 27.17 45 19854 515 1726367
Dizziness 123.56 27.17 230 19669 34131 1692751
Clostridium difficile colitis 121.22 27.17 60 19839 1544 1725338
Bone pain 120.32 27.17 77 19822 3285 1723597
Disease recurrence 120.27 27.17 70 19829 2512 1724370
Death 119.59 27.17 404 19495 87039 1639843
Gastrointestinal haemorrhage 117.52 27.17 141 19758 14126 1712756
Peritonitis 116.44 27.17 70 19829 2669 1724213
Parainfluenzae virus infection 116.35 27.17 34 19865 181 1726701
Neoplasm progression 114.88 27.17 74 19825 3193 1723689
Tachycardia 114.31 27.17 131 19768 12497 1714385
Weight decreased 113.11 27.17 176 19723 22577 1704305
Pain 111.93 27.17 191 19708 26466 1700416
Oral candidiasis 111.06 27.17 53 19846 1256 1725626
Ascites 110.05 27.17 89 19810 5497 1721385
Large intestine perforation 109.96 27.17 51 19848 1131 1725751
Seizure 109.91 27.17 164 19735 20277 1706605
Diffuse large B-cell lymphoma 109.05 27.17 50 19849 1079 1725803
Myopathy 108.61 27.17 58 19841 1755 1725127
Immunosuppression 108.46 27.17 46 19853 818 1726064
Malaise 107.62 27.17 199 19700 29366 1697516
Hypogammaglobulinaemia 107.58 27.17 42 19857 597 1726285
Candida infection 107.17 27.17 59 19840 1899 1724983
Blood culture positive 106.14 27.17 44 19855 737 1726145
Abdominal distension 104.96 27.17 92 19807 6352 1720530
Sinusitis 104.55 27.17 84 19815 5139 1721743
Diffuse large B-cell lymphoma recurrent 103.95 27.17 28 19871 104 1726778
Nocardiosis 103.82 27.17 39 19860 496 1726386
Pulmonary oedema 103.22 27.17 92 19807 6494 1720388
Bacterial sepsis 102.90 27.17 41 19858 617 1726265
Escherichia bacteraemia 102.83 27.17 34 19865 288 1726594
Fungal infection 101.86 27.17 60 19839 2202 1724680
Visual acuity reduced 100.90 27.17 73 19826 3815 1723067
Cataract 100.73 27.17 66 19833 2932 1723950
Upper respiratory tract infection 99.78 27.17 74 19825 4019 1722863
Mental status changes 99.48 27.17 87 19812 5988 1720894
Staphylococcal sepsis 99.00 27.17 48 19851 1179 1725703
Drug resistance 98.63 27.17 67 19832 3163 1723719
Lymphocyte count decreased 98.18 27.17 58 19841 2140 1724742
Therapeutic product effect incomplete 97.30 27.17 82 19817 5366 1721516
Product use issue 96.91 27.17 100 19799 8471 1718411
Atrial flutter 96.71 27.17 55 19844 1887 1724995
Orthostatic hypotension 94.97 27.17 67 19832 3364 1723518
Viral haemorrhagic cystitis 94.81 27.17 24 19875 65 1726817
Urinary retention 93.88 27.17 80 19819 5315 1721567
Hyperkalaemia 93.55 27.17 98 19801 8449 1718433
Erythema 92.74 27.17 125 19774 14063 1712819
Eye pain 92.47 27.17 57 19842 2274 1724608
Encephalopathy 92.09 27.17 73 19826 4379 1722503
Pain in extremity 91.92 27.17 143 19756 18329 1708553
Spinal compression fracture 91.58 27.17 41 19858 835 1726047
Oedema 91.35 27.17 88 19811 6860 1720022
Lung infiltration 91.30 27.17 55 19844 2104 1724778
Dysphagia 91.19 27.17 105 19794 10063 1716819
Brain oedema 90.44 27.17 55 19844 2141 1724741
Clostridium difficile infection 90.20 27.17 51 19848 1730 1725152
Neurotoxicity 89.33 27.17 53 19846 1971 1724911
Therapy non-responder 89.32 27.17 83 19816 6183 1720699
Staphylococcal bacteraemia 89.11 27.17 39 19860 751 1726131
H1N1 influenza 89.08 27.17 28 19871 198 1726684
Visual impairment 87.93 27.17 82 19817 6136 1720746
Epstein-Barr virus infection 87.74 27.17 43 19856 1082 1725800
Therapeutic response decreased 86.52 27.17 77 19822 5423 1721459
Pathological fracture 86.40 27.17 35 19864 551 1726331
Vision blurred 85.85 27.17 93 19806 8330 1718552
Osteomyelitis 85.69 27.17 54 19845 2241 1724641
Chest pain 85.26 27.17 144 19755 19770 1707112
Pneumonia fungal 85.24 27.17 33 19866 458 1726424
Acute pulmonary oedema 84.53 27.17 43 19856 1174 1725708
Therapy partial responder 83.89 27.17 29 19870 285 1726597
Osteonecrosis of jaw 83.57 27.17 68 19831 4235 1722647
Shock 83.44 27.17 67 19832 4094 1722788
Necrotising fasciitis 82.95 27.17 35 19864 614 1726268
Acute respiratory failure 82.73 27.17 58 19841 2882 1724000
Hepatotoxicity 82.53 27.17 59 19840 3025 1723857
Hypoaesthesia 82.26 27.17 98 19801 9737 1717145
C-reactive protein increased 82.05 27.17 77 19822 5808 1721074
Hepatitis B 81.56 27.17 44 19855 1359 1725523
Oesophagitis 81.56 27.17 47 19852 1654 1725228
Fluid overload 80.88 27.17 50 19849 2005 1724877
Escherichia infection 80.58 27.17 39 19860 954 1725928
Rib fracture 79.97 27.17 47 19852 1717 1725165
Nervous system disorder 79.95 27.17 53 19846 2401 1724481
Substance-induced psychotic disorder 79.53 27.17 27 19872 250 1726632
Bacterial infection 79.26 27.17 48 19851 1854 1725028
Refractory cytopenia with multilineage dysplasia 78.98 27.17 18 19881 25 1726857
Delirium 78.81 27.17 78 19821 6284 1720598
Psychotic disorder 77.97 27.17 70 19829 4986 1721896
Hepatitis B reactivation 77.75 27.17 29 19870 361 1726521
Rash maculo-papular 77.19 27.17 61 19838 3642 1723240
Muscle spasms 76.86 27.17 103 19796 11518 1715364
Pneumonia bacterial 76.62 27.17 40 19859 1154 1725728
Ileus 75.30 27.17 51 19848 2395 1724487
Hypophagia 73.74 27.17 58 19841 3439 1723443
Interstitial lung disease 73.60 27.17 92 19807 9604 1717278
Malignant neoplasm of unknown primary site 73.38 27.17 19 19880 58 1726824
Hepatocellular injury 73.38 27.17 56 19843 3175 1723707
Pneumatosis intestinalis 72.93 27.17 30 19869 492 1726390
Autonomic neuropathy 72.93 27.17 22 19877 133 1726749
Microsporidia infection 72.72 27.17 18 19881 43 1726839
Pancreatitis 72.62 27.17 79 19820 7108 1719774
Cerebral infarction 72.31 27.17 68 19831 5141 1721741
Cardio-respiratory arrest 71.86 27.17 89 19810 9204 1717678
Hypoalbuminaemia 71.76 27.17 41 19858 1419 1725463
Coagulopathy 71.66 27.17 52 19847 2729 1724153
Pneumonia viral 70.72 27.17 27 19872 360 1726522
Spinal pain 69.84 27.17 31 19868 618 1726264
Encephalitis 69.83 27.17 37 19862 1101 1725781
Paraesthesia 69.68 27.17 93 19806 10358 1716524
Blindness 69.15 27.17 51 19848 2745 1724137
Metabolic acidosis 68.34 27.17 67 19832 5335 1721547
Diverticulitis 68.07 27.17 47 19852 2278 1724604
Pancreatitis acute 67.84 27.17 59 19840 4028 1722854
Lethargy 67.47 27.17 76 19823 7108 1719774
Dyspnoea exertional 66.92 27.17 59 19840 4102 1722780
Bone lesion 66.19 27.17 27 19872 433 1726449
Blood bilirubin increased 65.79 27.17 70 19829 6140 1720742
Hypersensitivity 65.17 27.17 90 19809 10354 1716528
Thrombosis 64.63 27.17 76 19823 7445 1719437
Bradycardia 64.57 27.17 90 19809 10444 1716438
Pericarditis 64.56 27.17 39 19860 1499 1725383
Hodgkin's disease 64.21 27.17 31 19868 754 1726128
Autoimmune lymphoproliferative syndrome 64.10 27.17 13 19886 5 1726877
Ulcerative keratitis 63.99 27.17 25 19874 356 1726526
Disseminated intravascular coagulation 63.70 27.17 54 19845 3560 1723322
Atelectasis 63.56 27.17 42 19857 1892 1724990
Pneumonia cytomegaloviral 63.36 27.17 25 19874 366 1726516
Klebsiella infection 63.10 27.17 31 19868 784 1726098
Peripheral swelling 62.68 27.17 77 19822 7894 1718988
Haematuria 62.66 27.17 75 19824 7485 1719397
Gamma-glutamyltransferase increased 62.20 27.17 62 19837 5036 1721846
Systemic inflammatory response syndrome 62.00 27.17 31 19868 815 1726067
Neoplasm recurrence 61.80 27.17 25 19874 392 1726490
Haematocrit decreased 61.66 27.17 57 19842 4216 1722666
Gait disturbance 61.48 27.17 97 19802 12573 1714309
Acute myocardial infarction 61.24 27.17 79 19820 8508 1718374
Streptococcal bacteraemia 60.84 27.17 20 19879 166 1726716
Electrolyte imbalance 60.74 27.17 37 19862 1444 1725438
Pseudomonal sepsis 60.23 27.17 24 19875 361 1726521
Aspartate aminotransferase increased 60.19 27.17 88 19811 10668 1716214
Drug interaction 59.94 27.17 152 19747 27806 1699076
Stem cell transplant 59.06 27.17 25 19874 442 1726440
Blood lactate dehydrogenase increased 58.88 27.17 52 19847 3623 1723259
Pneumonia aspiration 58.71 27.17 61 19838 5205 1721677
Adenoviral hepatitis 58.59 27.17 14 19885 27 1726855
Drug ineffective for unapproved indication 58.36 27.17 39 19860 1790 1725092
Tachypnoea 58.28 27.17 43 19856 2315 1724567
Pneumonia influenzal 57.55 27.17 19 19880 160 1726722
Monoclonal immunoglobulin present 57.29 27.17 18 19881 127 1726755
Embolism 56.60 27.17 32 19867 1085 1725797
Hepatomegaly 56.36 27.17 37 19862 1648 1725234
Sudden death 56.11 27.17 46 19853 2894 1723988
Spinal cord compression 56.10 27.17 27 19872 652 1726230
Streptococcal infection 55.83 27.17 27 19872 659 1726223
Somnolence 55.04 27.17 108 19791 16631 1710251
Thrombotic microangiopathy 54.78 27.17 33 19866 1262 1725620
Guillain-Barre syndrome 54.09 27.17 29 19870 884 1725998
Cachexia 53.90 27.17 30 19869 986 1725896
Cardiac failure congestive 53.23 27.17 101 19798 15169 1711713
Intestinal perforation 52.81 27.17 35 19864 1584 1725298
Viral infection 52.71 27.17 44 19855 2839 1724043
Kaposi's sarcoma 52.66 27.17 28 19871 839 1726043
Generalised oedema 52.53 27.17 36 19863 1723 1725159
Anaphylactic shock 52.50 27.17 44 19855 2855 1724027
Progressive multifocal leukoencephalopathy 52.42 27.17 35 19864 1604 1725278
Bladder transitional cell carcinoma 52.23 27.17 22 19877 384 1726498
Cardiac amyloidosis 52.05 27.17 16 19883 104 1726778
Productive cough 52.00 27.17 48 19851 3543 1723339
Hypophosphataemia 51.91 27.17 32 19867 1276 1725606
Amyloidosis 51.58 27.17 21 19878 335 1726547
Failure to thrive 51.56 27.17 30 19869 1075 1725807
Cytokine release syndrome 51.49 27.17 24 19875 538 1726344
Periorbital infection 51.25 27.17 11 19888 9 1726873
Osteolysis 51.24 27.17 20 19879 284 1726598
Light chain analysis increased 51.10 27.17 17 19882 147 1726735
Tremor 50.99 27.17 91 19808 13040 1713842
Treatment failure 50.90 27.17 52 19847 4349 1722533
Post transplant lymphoproliferative disorder 50.64 27.17 26 19873 724 1726158
Hemiparesis 50.55 27.17 42 19857 2692 1724190
Fusarium infection 50.43 27.17 16 19883 117 1726765
Agitation 50.18 27.17 82 19817 10944 1715938
Campylobacter gastroenteritis 50.08 27.17 16 19883 120 1726762
Ileus paralytic 49.80 27.17 28 19871 939 1725943
Skin striae 49.74 27.17 16 19883 123 1726759
Adenovirus infection 49.54 27.17 22 19877 439 1726443
Blood pressure decreased 49.36 27.17 67 19832 7579 1719303
Oral pain 49.29 27.17 32 19867 1398 1725484
Herpes simplex 49.29 27.17 25 19874 678 1726204
Cholestasis 49.25 27.17 47 19852 3618 1723264
Paraplegia 49.17 27.17 23 19876 520 1726362
Pneumonia pneumococcal 48.73 27.17 19 19880 269 1726613
Pericardial effusion 48.48 27.17 45 19854 3345 1723537
Pneumonia legionella 48.23 27.17 20 19879 335 1726547
Pneumonia escherichia 47.99 27.17 14 19885 74 1726808
Hodgkin's disease refractory 47.87 27.17 10 19889 6 1726876
Peripheral motor neuropathy 47.69 27.17 18 19881 232 1726650
Abdominal pain upper 47.63 27.17 80 19819 10921 1715961
Cerebrovascular accident 46.76 27.17 105 19794 17761 1709121
Pleuritic pain 46.66 27.17 21 19878 433 1726449
Cardiac failure acute 46.52 27.17 29 19870 1180 1725702
Hepatic failure 46.37 27.17 57 19842 5846 1721036
Anaphylactic reaction 46.37 27.17 58 19841 6055 1720827
Cardiomyopathy 46.21 27.17 40 19859 2712 1724170
Glaucoma 46.19 27.17 28 19871 1083 1725799
Enterocolitis 46.16 27.17 26 19873 875 1726007
Blood potassium decreased 46.10 27.17 37 19862 2258 1724624
Corneal oedema 46.05 27.17 19 19880 314 1726568
Visceral leishmaniasis 45.89 27.17 15 19884 122 1726760
Premature baby 45.88 27.17 41 19858 2901 1723981
Malignant melanoma 45.79 27.17 32 19867 1581 1725301
Gallbladder oedema 44.88 27.17 12 19887 43 1726839
Respiratory tract infection fungal 44.78 27.17 14 19885 97 1726785
Abdominal wall abscess 44.41 27.17 14 19885 100 1726782
Mania 44.15 27.17 35 19864 2098 1724784
Peripheral sensorimotor neuropathy 43.73 27.17 16 19883 188 1726694
Musculoskeletal chest pain 43.59 27.17 29 19870 1321 1725561
Bowen's disease 43.49 27.17 18 19881 300 1726582
Red blood cell count decreased 43.44 27.17 44 19855 3642 1723240
Herpes zoster disseminated 43.43 27.17 15 19884 147 1726735
Haemorrhage 43.25 27.17 72 19827 9757 1717125
VIth nerve paralysis 43.13 27.17 16 19883 196 1726686
Ocular hypertension 42.91 27.17 16 19883 199 1726683
Blood albumin decreased 42.87 27.17 31 19868 1617 1725265
Uveitis 42.44 27.17 26 19873 1025 1725857
Light chain disease 42.29 27.17 10 19889 18 1726864
Testicular germ cell cancer metastatic 42.14 27.17 9 19890 7 1726875
Pulmonary haemorrhage 42.03 27.17 31 19868 1668 1725214
Skin infection 42.00 27.17 25 19874 935 1725947
Oropharyngeal pain 41.90 27.17 49 19850 4769 1722113
Skin lesion 41.63 27.17 39 19860 2933 1723949
Haematopoietic stem cell mobilisation 41.59 27.17 9 19890 8 1726874
Intestinal atresia 41.59 27.17 9 19890 8 1726874
Stress cardiomyopathy 41.29 27.17 18 19881 343 1726539
Hepatic function abnormal 41.20 27.17 59 19840 7015 1719867
Acute coronary syndrome 41.11 27.17 35 19864 2320 1724562
Dysphonia 41.10 27.17 42 19857 3513 1723369
Chronic kidney disease 41.08 27.17 46 19853 4271 1722611
Metastases to retroperitoneum 40.97 27.17 10 19889 22 1726860
Rectal adenocarcinoma 40.92 27.17 14 19885 133 1726749
Systemic candida 40.91 27.17 18 19881 351 1726531
Duodenal perforation 40.86 27.17 15 19884 178 1726704
End stage renal disease 40.69 27.17 21 19878 591 1726291
Acute monocytic leukaemia 40.60 27.17 11 19888 42 1726840
Encephalitis enteroviral 40.59 27.17 9 19890 10 1726872
Hepatic steatosis 40.27 27.17 36 19863 2548 1724334
Malnutrition 40.19 27.17 29 19870 1508 1725374
Refractory anaemia with an excess of blasts 40.18 27.17 13 19886 102 1726780
Disorientation 40.06 27.17 51 19848 5418 1721464
Metastases to central nervous system 40.05 27.17 29 19870 1516 1725366
Foetal exposure during pregnancy 39.95 27.17 55 19844 6304 1720578
Leukocytosis 39.51 27.17 41 19858 3492 1723390
Listeriosis 39.50 27.17 14 19885 149 1726733
Blood count abnormal 39.26 27.17 28 19871 1429 1725453
Anaesthetic complication neurological 39.26 27.17 10 19889 28 1726854
Keratitis fungal 39.26 27.17 10 19889 28 1726854
Opportunistic infection 39.24 27.17 17 19882 319 1726563
Mouth ulceration 38.93 27.17 30 19869 1725 1725157
Choroiditis 38.89 27.17 11 19888 51 1726831
Spinal fracture 38.84 27.17 24 19875 961 1725921
Compression fracture 38.80 27.17 18 19881 399 1726483
Pneumothorax 38.78 27.17 36 19863 2676 1724206
Hypoglycaemia 38.72 27.17 63 19836 8375 1718507
Myelopathy 38.66 27.17 17 19882 331 1726551
Neutropenic colitis 38.59 27.17 16 19883 268 1726614
Hyperviscosity syndrome 38.37 27.17 11 19888 54 1726828
Diabetic ketoacidosis 38.34 27.17 39 19860 3244 1723638
Hypomagnesaemia 38.31 27.17 32 19867 2066 1724816
Chronic obstructive pulmonary disease 38.17 27.17 52 19847 5901 1720981
Leukoencephalopathy 38.07 27.17 22 19877 778 1726104
Pseudomonas test positive 38.04 27.17 13 19886 123 1726759
Pneumonia klebsiella 38.02 27.17 17 19882 345 1726537
Meningitis bacterial 37.99 27.17 15 19884 220 1726662
Appendicitis 37.89 27.17 25 19874 1123 1725759
B-cell lymphoma recurrent 37.57 27.17 11 19888 59 1726823
Upper gastrointestinal haemorrhage 37.55 27.17 37 19862 2962 1723920
Pulmonary alveolar haemorrhage 37.55 27.17 25 19874 1140 1725742
Cardiotoxicity 37.36 27.17 22 19877 806 1726076
Blood alkaline phosphatase increased 37.35 27.17 48 19851 5147 1721735
Aplasia 37.12 27.17 18 19881 442 1726440
Inappropriate antidiuretic hormone secretion 36.86 27.17 29 19870 1719 1725163
Dysgeusia 36.85 27.17 47 19852 5002 1721880
Intentional product use issue 36.78 27.17 35 19864 2684 1724198
Prostate cancer stage II 36.74 27.17 10 19889 39 1726843
Gastrointestinal toxicity 36.60 27.17 17 19882 378 1726504
Cerebral thrombosis 36.57 27.17 15 19884 244 1726638
Cerebral ischaemia 36.45 27.17 24 19875 1074 1725808
Steroid withdrawal syndrome 36.39 27.17 11 19888 67 1726815
Abscess 36.36 27.17 30 19869 1904 1724978
West Nile viral infection 36.35 27.17 12 19887 101 1726781
Altered state of consciousness 36.29 27.17 39 19860 3458 1723424
Bacterial test positive 36.14 27.17 18 19881 469 1726413
Hepatitis 35.97 27.17 46 19853 4909 1721973
Neutropenic infection 35.89 27.17 13 19886 148 1726734
Hydrocephalus 35.85 27.17 22 19877 870 1726012
Metastases to muscle 35.65 27.17 9 19890 24 1726858
B-cell type acute leukaemia 35.65 27.17 9 19890 24 1726858
Agranulocytosis 35.57 27.17 39 19860 3537 1723345
Haematemesis 35.56 27.17 43 19856 4334 1722548
Oxygen saturation decreased 35.52 27.17 49 19850 5626 1721256
Ocular hyperaemia 35.35 27.17 30 19869 1980 1724902
Haemolysis 35.35 27.17 24 19875 1131 1725751
Fluid retention 35.24 27.17 40 19859 3769 1723113
Clostridium test positive 35.14 27.17 15 19884 271 1726611
Squamous cell carcinoma 35.12 27.17 29 19870 1842 1725040
Venous thrombosis 35.05 27.17 20 19879 690 1726192
Sinus tachycardia 35.03 27.17 33 19866 2499 1724383
Ill-defined disorder 34.99 27.17 29 19870 1852 1725030
Generalised tonic-clonic seizure 34.93 27.17 41 19858 4005 1722877
Non-cardiac chest pain 34.93 27.17 18 19881 505 1726377
Lentigo maligna 34.90 27.17 10 19889 49 1726833
Myositis 34.68 27.17 27 19872 1576 1725306
Wound infection 34.41 27.17 22 19877 936 1725946
Mucosal infection 34.39 27.17 9 19890 29 1726853
Gastrointestinal disorder 34.34 27.17 44 19855 4704 1722178
Left ventricular dysfunction 34.32 27.17 24 19875 1187 1725695
Dyspepsia 34.19 27.17 45 19854 4940 1721942
Intussusception 34.17 27.17 12 19887 124 1726758
Skin ulcer 34.17 27.17 34 19865 2754 1724128
Oral herpes 34.16 27.17 20 19879 725 1726157
Metastases to bone marrow 34.14 27.17 11 19888 85 1726797
Mantle cell lymphoma recurrent 33.94 27.17 10 19889 55 1726827
Odynophagia 33.86 27.17 20 19879 737 1726145
Hypovolaemia 33.80 27.17 24 19875 1216 1725666
Emotional disorder 33.78 27.17 23 19876 1089 1725793
Corneal infiltrates 33.64 27.17 10 19889 57 1726825
Small intestinal obstruction 33.64 27.17 28 19871 1799 1725083
Acanthamoeba keratitis 33.63 27.17 7 19892 4 1726878
Acute lymphocytic leukaemia refractory 33.63 27.17 8 19891 15 1726867
Nicotinic acid deficiency 33.63 27.17 8 19891 15 1726867
Nasopharyngitis 33.38 27.17 65 19834 9945 1716937
Morganella infection 33.29 27.17 9 19890 34 1726848
Inflammation 33.24 27.17 37 19862 3413 1723469
Stoma site pain 33.21 27.17 10 19889 60 1726822
Colon cancer 33.15 27.17 28 19871 1836 1725046
Malignant transformation 33.07 27.17 10 19889 61 1726821
Bladder transitional cell carcinoma stage 0 33.03 27.17 7 19892 5 1726877
Minimal residual disease 33.03 27.17 7 19892 5 1726877
Post procedural complication 32.89 27.17 31 19868 2349 1724533
Anuria 32.83 27.17 28 19871 1860 1725022
Hepatitis viral 32.79 27.17 12 19887 141 1726741
Transaminases increased 32.67 27.17 39 19860 3878 1723004
Escherichia test positive 32.64 27.17 12 19887 143 1726739
Ear pain 32.59 27.17 20 19879 791 1726091
General physical condition abnormal 32.34 27.17 19 19880 693 1726189
Respiratory syncytial virus infection 32.27 27.17 19 19880 696 1726186
Malignant melanoma in situ 32.20 27.17 12 19887 149 1726733
Abdominal sepsis 31.98 27.17 12 19887 152 1726730
Rectal haemorrhage 31.94 27.17 46 19853 5496 1721386
Waldenstrom's macroglobulinaemia 31.53 27.17 10 19889 73 1726809
Cellulitis orbital 31.53 27.17 10 19889 73 1726809
Hyperuricaemia 31.49 27.17 21 19878 960 1725922
Subdural haematoma 31.47 27.17 36 19863 3421 1723461
Toxicity to various agents 31.41 27.17 125 19774 29016 1697866
Epstein-Barr viraemia 31.30 27.17 11 19888 114 1726768
Brain herniation 31.29 27.17 18 19881 631 1726251
Leukaemia recurrent 31.27 27.17 14 19885 285 1726597
Staphylococcus test positive 31.24 27.17 16 19883 443 1726439
Proteus infection 31.21 27.17 11 19888 115 1726767
Neuralgia 31.17 27.17 24 19875 1378 1725504
Lymphadenopathy 31.14 27.17 39 19860 4075 1722807
Haemolytic anaemia 31.13 27.17 27 19872 1835 1725047
Cognitive disorder 31.12 27.17 40 19859 4290 1722592
Fungal sepsis 31.02 27.17 12 19887 166 1726716
Low birth weight baby 30.94 27.17 20 19879 867 1726015
Cystitis haemorrhagic 30.85 27.17 18 19881 648 1726234
Haematoma 30.82 27.17 38 19861 3907 1722975
Liver function test abnormal 30.80 27.17 46 19853 5680 1721202
Lung cancer metastatic 30.76 27.17 17 19882 551 1726331
Pulmonary sepsis 30.70 27.17 14 19885 298 1726584
Cytomegalovirus viraemia 30.64 27.17 17 19882 555 1726327
Glioblastoma multiforme 30.50 27.17 13 19886 234 1726648
Metapneumovirus infection 30.31 27.17 10 19889 84 1726798
Urosepsis 30.25 27.17 24 19875 1440 1725442
Enterobacter sepsis 30.21 27.17 10 19889 85 1726797
Drug intolerance 30.20 27.17 47 19852 6015 1720867
Hyperglycaemic hyperosmolar nonketotic syndrome 30.08 27.17 12 19887 181 1726701
Febrile infection 29.96 27.17 12 19887 183 1726699
Drug-induced liver injury 29.96 27.17 34 19865 3203 1723679
Lupus pneumonitis 29.81 27.17 6 19893 2 1726880
Pneumoperitoneum 29.79 27.17 14 19885 320 1726562
Partial seizures 29.76 27.17 18 19881 693 1726189
Gastrointestinal infection 29.65 27.17 17 19882 592 1726290
Microangiopathic haemolytic anaemia 29.63 27.17 11 19888 135 1726747
Lung consolidation 29.62 27.17 17 19882 593 1726289
Potentiating drug interaction 29.62 27.17 18 19881 699 1726183
Pulmonary toxicity 29.47 27.17 19 19880 820 1726062
Fungal skin infection 29.35 27.17 14 19885 331 1726551
Bone disorder 29.25 27.17 23 19876 1362 1725520
Arrhythmia 29.08 27.17 46 19853 5970 1720912
Contusion 29.05 27.17 43 19856 5266 1721616
Graft versus host disease 29.00 27.17 24 19875 1529 1725353
Pseudomonal bacteraemia 28.95 27.17 10 19889 98 1726784
Hepatosplenomegaly 28.94 27.17 17 19882 620 1726262
Vitritis 28.85 27.17 11 19888 146 1726736
Papilloedema 28.84 27.17 17 19882 624 1726258
Thoracic vertebral fracture 28.83 27.17 12 19887 203 1726679
Mesenteric vascular insufficiency 28.80 27.17 7 19892 15 1726867
Chronic lymphocytic leukaemia 28.72 27.17 19 19880 857 1726025
Optic nerve disorder 28.72 27.17 11 19888 148 1726734
Chest discomfort 28.69 27.17 51 19848 7280 1719602
Cholecystitis acute 28.64 27.17 19 19880 861 1726021
Meningoencephalitis herpetic 28.62 27.17 12 19887 207 1726675
Brain abscess 28.41 27.17 15 19884 443 1726439
Cardiogenic shock 28.38 27.17 29 19870 2425 1724457
Organising pneumonia 28.29 27.17 19 19880 879 1726003
Antithrombin III deficiency 28.20 27.17 7 19892 17 1726865
Squamous cell carcinoma of lung 28.15 27.17 13 19886 285 1726597
Depression 28.07 27.17 83 19816 16586 1710296
Body temperature increased 28.03 27.17 30 19869 2647 1724235
Change of bowel habit 27.94 27.17 11 19888 160 1726722
Metastases to spleen 27.89 27.17 9 19890 70 1726812
Haemoglobin abnormal 27.86 27.17 16 19883 559 1726323
Oral disorder 27.84 27.17 17 19882 666 1726216
Foetal growth restriction 27.82 27.17 17 19882 667 1726215
Morphoea 27.79 27.17 8 19891 40 1726842
Anxiety 27.76 27.17 79 19820 15448 1711434
Cardiomegaly 27.75 27.17 28 19871 2306 1724576
Irritability 27.71 27.17 43 19856 5489 1721393
Systemic mycosis 27.69 27.17 11 19888 164 1726718
Varicella 27.66 27.17 14 19885 378 1726504
Cerebral haemorrhage 27.63 27.17 46 19853 6231 1720651
Sinusitis fungal 27.56 27.17 9 19890 73 1726809
Retinal haemorrhage 27.54 27.17 21 19878 1188 1725694
Enterovesical fistula 27.51 27.17 11 19888 167 1726715
Cerebral venous thrombosis 27.45 27.17 11 19888 168 1726714
Cryptococcosis 27.43 27.17 13 19886 303 1726579
Total lung capacity decreased 27.21 27.17 10 19889 119 1726763

Pharmacologic Action:

SourceCodeDescription
ATC A01AC02 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Corticosteroids for local oral treatment
ATC C05AA09 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AB19 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC D07XB05 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, moderately potent, other combinations
ATC D10AA03 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Corticosteroids, combinations for treatment of acne
ATC H02AB02 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD03 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC S01BA01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01CB01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA06 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC S03BA01 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS
Corticosteroids
ATC D07CB04 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, moderately potent, combinations with antibiotics
ATC R01AD53 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC S01CA01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S02CA06 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S03CA01 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA EPC N0000175576 Corticosteroid
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000932 Antiemetics
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:37962 adrenergic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35472 anti-inflammatory drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Otitis externa indication 3135009
Keratitis indication 5888003 DOID:4677
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Cyclitis indication 17657000
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Keloid scar indication 33659008
Crohn's disease indication 34000006
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Punctate keratitis indication 42513006 DOID:12197
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Iritis indication 65074000 DOID:1406
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Blepharoconjunctivitis indication 68659002 DOID:2456
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Perforation of cornea indication 74895004
Iridocyclitis indication 77971008
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Corneal abrasion indication 85848002
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Corneal ulcer indication 91514001 DOID:8463
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Multiple myeloma indication 109989006 DOID:9538
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Mycosis fungoides indication 118618005
Uveitis indication 128473001 DOID:13141
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Central retinal vein occlusion with macular edema indication 232039004
Branch retinal vein occlusion with macular edema indication 232048009
Malignant otitis externa due to Pseudomonas aeruginosa indication 232230009
Scalp psoriasis indication 238608008
Punctate keratopathy indication 246936005
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Infective otitis media indication 312218008
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Herpes zoster keratitis indication 397573005
Rosacea indication 398909004 DOID:8881
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Allergic otitis externa indication 405821001
Anterior uveitis indication 410692006 DOID:1407
Autoimmune hemolytic anemia indication 413603009 DOID:718
Allergic conjunctivitis indication 473460002 DOID:11204
Otitis Externa Seborrhea indication
Post-Op Ocular Inflammation indication
Otitis Externa Eczema indication
Non-infectious Posterior Uveitis indication
Progressive Diffuse Large B-Cell Lymphoma indication
Synovitis due to Osteoarthritis indication
Tuberculosis Meningitis Treatment Adjunct indication
Transfusion Reaction Urticaria indication
Erythroblastic Anemia indication
Staphylococcus Aureus Otitis Externa indication
Diagnostic Test for Cushing's Syndrome indication
Systemic Dermatomyositis indication
Pericarditis off-label use 3238004 DOID:1787
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Tendinitis off-label use 34840004 DOID:971
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Croup off-label use 71186008 DOID:9395
Pemphigoid off-label use 86142006
Myasthenia gravis off-label use 91637004 DOID:437
Polyarteritis nodosa off-label use 155441006 DOID:9810
Chemotherapy-induced nausea and vomiting off-label use 236084000
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Metastatic Prostate Carcinoma off-label use
Prevention of Radiation-Induced Nausea and Vomiting off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Prevention of Post-Operative Nausea and Vomiting off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Endophthalmitis contraindication 1847009 DOID:4692
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Herpes simplex keratitis contraindication 9389005
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Glaucoma contraindication 23986001 DOID:1686
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Severe myopia contraindication 34187009
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Retinal detachment contraindication 42059000 DOID:5327
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Bacterial infection of eye contraindication 128984004
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Injury of eye region contraindication 282752000
Varicella-zoster virus infection contraindication 309465005
Viral eye infection contraindication 312132001
Viral ear infection contraindication 312137007
Osteopenia contraindication 312894000
Vaccinia keratitis contraindication 397552005
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 12.45 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
9% DEXYCU KIT EYEPOINT PHARMS N208912 Feb. 9, 2018 RX SUSPENSION INTRAOCULAR 10022502 Sept. 12, 2020 TREATMENT OF POSTOPERATIVE INFLAMMATION
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 6726918 Oct. 20, 2020 TREATMENT OF MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 6726918 Oct. 20, 2020 TREATMENT OF UVEITIS
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8043628 Oct. 20, 2020 TREATMENT OF MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8088407 Oct. 20, 2020 TREATMENT OF MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 9012437 Oct. 20, 2020 TREATMENT OF MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 9283178 Oct. 20, 2020 TREATMENT OF MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 9592242 Oct. 20, 2020 INTRAVITREAL TREATMENT OF DIABETIC MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 9592242 Oct. 20, 2020 INTRAVITREAL TREATMENT OF MACULAR EDEMA FOLLOWING BRANCH RETINAL VEIN OCCLUSION (BRVO) OR CENTRAL RETINAL VEIN OCCLUSION (CRVO)
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 9775849 Oct. 20, 2020 INTRAVITREAL TREATMENT OF DIABETIC MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 9775849 Oct. 20, 2020 INTRAVITREAL TREATMENT OF MACULAR EDEMA FOLLOWING BRANCH RETINAL VEIN OCCLUSION (BRVO) OR CENTRAL RETINAL VEIN OCCLUSION (CRVO)
0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 9149486 Sept. 13, 2022 TREATMENT OF ACUTE OTITIS MEDIA
0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 9345714 Sept. 13, 2022 TREATMENT OF ACUTE OTITIS MEDIA
0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 9402805 Sept. 13, 2022 TREATMENT OF ACUTE OTITIS EXTERNA
0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 9402805 Sept. 13, 2022 TREATMENT OF ACUTE OTITIS MEDIA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8034366 Jan. 9, 2023 TREATMENT OF MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8034366 Jan. 9, 2023 TREATMENT OF UVEITIS
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8506987 Jan. 9, 2023 TREATMENT OF MACULAR EDEMA
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 8506987 Jan. 9, 2023 TREATMENT OF UVEITIS
0.7MG OZURDEX ALLERGAN N022315 June 17, 2009 RX IMPLANT INTRAVITREAL 6899717 Nov. 1, 2023 DELIVERING AN OCULAR IMPLANT AS DESCRIBED IN THE DOSAGE AND ADMINISTRATION SECTION OF THE APPROVED LABELING OF OZURDEX
0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 8846650 June 4, 2025 TREATMENT OF ACUTE OTITIS MEDIA
0.05% TOBRADEX ST EYEVANCE N050818 Feb. 13, 2009 RX SUSPENSION/DROPS OPHTHALMIC 8101582 Dec. 19, 2027 USE OF A COMBINATION OF TOBRAMYCIN AND DEXAMETHASONE TO TREAT OCULAR INFLAMMATION WHERE AN INFECTION OR RISK OF INFECTION EXISTS
0.05% TOBRADEX ST EYEVANCE N050818 Feb. 13, 2009 RX SUSPENSION/DROPS OPHTHALMIC 7795316 Aug. 3, 2028 USE OF A COMBINATION OF TOBRAMYCIN AND DEXAMETHASONE TO TREAT OCULAR INFLAMMATION WHERE AN INFECTION OR RISK OF INFECTION EXISTS
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC 8563027 Feb. 12, 2030 DEXTENZA IS APPROVED FOR THE TREATMENT OF OCULAR PAIN FOLLOWING OPHTHALMIC SURGERY
9% DEXYCU KIT EYEPOINT PHARMS N208912 Feb. 9, 2018 RX SUSPENSION INTRAOCULAR 10028965 May 23, 2034 TREATMENT OF POSTOPERATIVE INFLAMMATION

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
9% DEXYCU KIT EYEPOINT PHARMS N208912 Feb. 9, 2018 RX SUSPENSION INTRAOCULAR Feb. 9, 2021 NEW PRODUCT
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC Nov. 30, 2021 NEW PRODUCT
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC June 20, 2022 TREATMENT OF OCULAR INFLAMMATION FOLLOWING OPHTHALMIC SURGERY
20MG HEMADY DEXCEL PHARMA N211379 Oct. 3, 2019 RX TABLET ORAL Oct. 3, 2026 INDICATED IN COMBINATION WITH OTHER ANTI-MYELOMA PRODUCTS FOR THE TREATMENT OF ADULTS WITH MULTIPLE MYELOMA (MM)

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8.88 WOMBAT-PK CHEMBL
Interleukin-5 Cytokine IC50 8.46 WOMBAT-PK
Mineralocorticoid receptor Nuclear hormone receptor EC50 9 WOMBAT-PK
Annexin A1 Cytosolic other WOMBAT-PK
Progesterone receptor Nuclear hormone receptor Ki 6.25 CHEMBL
Androgen receptor Nuclear hormone receptor Ki 5.85 CHEMBL
Prostaglandin G/H synthase 2 Enzyme Ki 6.89 PDSP
Interleukin-4 Cytokine IC50 8.33 WOMBAT-PK
Androgen receptor Transcription factor Ki 4.79 DRUG MATRIX
Progesterone receptor Transcription factor Ki 5.52 DRUG MATRIX
Fatty acid-binding protein, liver Unclassified Ki 4.66 CHEMBL
Glucocorticoid receptor Transcription factor IC50 7.66 CHEMBL
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor AGONIST EC50 6.10 IUPHAR

External reference:

IDSource
D003907 MESH_DESCRIPTOR_UI
4017922 VUID
N0000146273 NUI
C0011777 UMLSCUI
D00292 KEGG_DRUG
7561000 SNOMEDCT_US
4017922 VANDF
002174 NDDF
6848 MMSL
3264 RXNORM
372584003 SNOMEDCT_US
4552 MMSL
d00206 MMSL
7S5I7G3JQL UNII
816 INN_ID
CHEMBL384467 ChEMBL_ID
CHEMBL1200637 ChEMBL_ID
DEX PDB_CHEM_ID
DB01234 DRUGBANK_ID
CHEBI:41879 CHEBI
2768 IUPHAR_LIGAND_ID
CHEMBL2021430 ChEMBL_ID
5743 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
OZURDEX HUMAN PRESCRIPTION DRUG LABEL 1 0023-3348 IMPLANT 0.70 mg INTRAVITREAL NDA 14 sections
Dexamethasone Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3176 SOLUTION, CONCENTRATE 1 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-3177 SOLUTION 0.50 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4179 TABLET 0.50 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4180 TABLET 0.75 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4181 TABLET 1 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4182 TABLET 1.50 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4183 TABLET 2 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4184 TABLET 4 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4186 TABLET 6 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8174 TABLET 1 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8175 TABLET 4 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8176 TABLET 2 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8179 TABLET 0.50 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8180 TABLET 0.75 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8181 TABLET 1.50 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8183 TABLET 6 mg ORAL ANDA 11 sections
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0065-0631 OINTMENT 1 mg OPHTHALMIC NDA 11 sections
TobraDex HUMAN PRESCRIPTION DRUG LABEL 2 0065-0647 SUSPENSION/ DROPS 1 mg OPHTHALMIC NDA 10 sections
TobraDex HUMAN PRESCRIPTION DRUG LABEL 2 0065-0648 OINTMENT 1 mg OPHTHALMIC NDA 12 sections
TOBRADEX ST HUMAN PRESCRIPTION DRUG LABEL 2 0065-0652 SUSPENSION/ DROPS 0.50 mg OPHTHALMIC NDA 14 sections
CIPRODEX HUMAN PRESCRIPTION DRUG LABEL 2 0065-8533 SUSPENSION/ DROPS 1 mg AURICULAR (OTIC) NDA 18 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0095-0087 TABLET 1.50 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0095-0088 TABLET 1.50 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0095-0089 TABLET 1.50 mg ORAL ANDA 11 sections
Neomycin and Polymyxin B Sulfates and Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 3 0574-4160 OINTMENT 1 mg OPHTHALMIC ANDA 10 sections
Maxidex HUMAN PRESCRIPTION DRUG LABEL 1 0998-0615 SUSPENSION 1 mg OPHTHALMIC NDA 11 sections
Maxitrol HUMAN PRESCRIPTION DRUG LABEL 3 0998-0630 SUSPENSION 1 mg OPHTHALMIC NDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 10544-211 TABLET 1.50 mg ORAL ANDA 11 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 10544-212 TABLET 4 mg ORAL ANDA 11 sections