fluprednidene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 4553 2193-87-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fluprednidene
  • fluprednylidene
  • Molecular weight: 390.45
  • Formula: C22H27FO5
  • CLOGP: 1.70
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.52
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,CDK5,EIF2AK3,GRK2,ITK,MAPK10,PDK1,PDK2,PDK4,PRKDC 10
kinase-selectivity-class EIF2AK3,GRK2,MAP2K6,MAP3K14 4
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 12.618 Moderate 0.70
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 Moderate 0.70
rat-kpuu-brain Rat brain Kpuu 0.042 % Moderate 0.70

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AB07 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC D07CB02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, moderately potent, combinations with antibiotics
ATC D07XB03 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, moderately potent, other combinations

Related Drugs by ATC class:

D07AB Corticosteroids, moderately potent (group II) 12 drugs
alclometasone dipropionateclobetasone butyrateclocortolone pivalatedesonidedexamethasoneflumetasonefluocortin butylfluorometholonefluperolonehydrocortisone butyratehydrocortisone probutatetriamcinolone
D07CB Corticosteroids, moderately potent, combinations with antibiotics 4 drugs
dexamethasoneflumetasonefluorometholonetriamcinolone
D07XB Corticosteroids, moderately potent, other combinations 4 drugs
dexamethasoneflumetasonefluorometholonetriamcinolone

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.18 acidic
pKa2 11.54 acidic
pKa3 13.69 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07201 KEGG_DRUG
CHEBI:135989 CHEBI
CHEMBL2106763 ChEMBL_ID
2450 INN_ID
DB08970 DRUGBANK_ID
FA517NS3N7 UNII
236650 RXNORM
006528 NDDF
414275002 SNOMEDCT_US
414277005 SNOMEDCT_US
C0771950 UMLSCUI
11794741 PUBCHEM_CID

Pharmaceutical products:

None