hydrocortisone probutate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 4569 72590-77-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrocortisone buteprate
  • hydrocortisone probutate
  • pandel
  • Molecular weight: 488.62
  • Formula: C28H40O7
  • CLOGP: 4.55
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 106.97
  • ALOGS: -5.24
  • ROTB: 9
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.23 mg/mL Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,STK33,SYK,TEK,TGFBR1 28
kinase-selectivity-class AXL,GRK2,MAP2K6 3
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Feb. 28, 1997 FDA FOUGERA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lip dry 254.23 78.93 225 27380 100730 90500112
Facet joint syndrome 251.19 78.93 221 27384 98168 90502674
Bursitis 219.54 78.93 234 27371 131420 90469422
Liver injury 190.73 78.93 247 27358 170320 90430522
Breast cancer stage III 190.54 78.93 177 27428 84270 90516572
Osteoarthritis 186.22 78.93 262 27343 195468 90405374
Live birth 184.67 78.93 169 27436 78938 90521904
Fibromyalgia 179.99 78.93 265 27340 206004 90394838
Dry mouth 178.99 78.93 249 27356 183810 90417032
Inflammation 174.25 78.93 242 27363 178350 90422492
Folliculitis 168.94 78.93 256 27349 204097 90396745
C-reactive protein abnormal 167.19 78.93 200 27405 127229 90473613
Injury 158.56 78.93 244 27361 197105 90403737
Peripheral venous disease 155.68 78.93 158 27447 83763 90517079
Type 2 diabetes mellitus 150.42 78.93 242 27363 203002 90397840
Nail disorder 149.29 78.93 132 27473 58935 90541907
Onychomycosis 146.54 78.93 108 27497 37268 90563574
Muscle injury 142.70 78.93 219 27386 176435 90424407
Obesity 140.68 78.93 167 27438 105340 90495502
Blepharospasm 140.31 78.93 124 27481 55321 90545521
Duodenal ulcer perforation 139.17 78.93 245 27360 221043 90379799
Night sweats 136.92 78.93 182 27423 128584 90472258
Lung disorder 134.18 78.93 195 27410 149688 90451154
Back injury 133.68 78.93 112 27493 46510 90554332
Irritable bowel syndrome 133.45 78.93 232 27373 207216 90393626
Epilepsy 133.20 78.93 144 27461 82062 90518780
Blood cholesterol increased 132.99 78.93 232 27373 207780 90393062
Ill-defined disorder 132.50 78.93 217 27388 184674 90416168
Musculoskeletal pain 130.92 78.93 207 27398 171044 90429798
Onychomadesis 130.85 78.93 110 27495 45888 90554954
Impaired healing 129.18 78.93 245 27360 233954 90366888
Mobility decreased 128.18 78.93 254 27351 250480 90350362
Lower respiratory tract infection 123.43 78.93 250 27355 250409 90350433
Psoriatic arthropathy 121.17 78.93 235 27370 228100 90372742
Drug ineffective 121.13 78.93 147 27458 1384151 89216691
Helicobacter infection 119.80 78.93 233 27372 226617 90374225
Hand deformity 117.78 78.93 271 27334 296091 90304751
Deep vein thrombosis postoperative 111.15 78.93 122 27483 70687 90530155
Joint range of motion decreased 110.67 78.93 169 27436 135474 90465368
Hypercholesterolaemia 109.38 78.93 144 27461 100748 90500094
C-reactive protein 108.26 78.93 84 27521 31283 90569559
Rheumatic fever 106.01 78.93 177 27428 152944 90447898
Wheezing 101.57 78.93 224 27381 237856 90362986
Wound infection 100.42 78.93 142 27463 106260 90494582
Autoimmune disorder 94.96 78.93 117 27488 76627 90524215
Hypoaesthesia 91.06 78.93 255 27350 313955 90286887
Gait inability 89.21 78.93 160 27445 146296 90454546
Adverse reaction 86.44 78.93 72 27533 29640 90571202
Glossodynia 82.53 78.93 250 27355 321529 90279313
Normal newborn 81.56 78.93 63 27542 23299 90577543
Pericarditis 79.97 78.93 221 27384 269930 90330912

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lip dry 297.34 124.02 224 26795 99859 110462421
Facet joint syndrome 286.06 124.02 216 26803 96612 110465668
Bursitis 257.98 124.02 230 26789 129688 110432592
Liver injury 251.66 124.02 242 26777 150171 110412109
Osteoarthritis 249.07 124.02 263 26756 182360 110379920
Fibromyalgia 241.77 124.02 251 26768 170658 110391622
Breast cancer stage III 241.45 124.02 180 26839 78937 110483343
Live birth 239.09 124.02 170 26849 69314 110492966
Hand deformity 225.16 124.02 272 26747 218234 110344046
Folliculitis 224.25 124.02 239 26780 167414 110394866
Injury 223.62 124.02 245 26774 177020 110385260
Muscle injury 221.40 124.02 219 26800 140588 110421692
Inflammation 211.34 124.02 248 26771 192990 110369290
Irritable bowel syndrome 210.66 124.02 229 26790 163986 110398294
Type 2 diabetes mellitus 208.17 124.02 236 26783 176996 110385284
Impaired healing 197.94 124.02 242 26777 196475 110365805
Duodenal ulcer perforation 197.53 124.02 230 26789 177470 110384810
Helicobacter infection 194.86 124.02 231 26788 181646 110380634
Ill-defined disorder 194.69 124.02 215 26804 156638 110405642
Nail disorder 186.15 124.02 136 26883 57799 110504481
Peripheral venous disease 185.17 124.02 158 26861 83959 110478321
Glossodynia 183.90 124.02 248 26771 221756 110340524
Mobility decreased 181.31 124.02 255 26764 237167 110325113
Psoriatic arthropathy 178.72 124.02 230 26789 196531 110365749
Dry mouth 177.36 124.02 231 26788 199717 110362563
Pemphigus 173.62 124.02 237 26782 214333 110347947
Onychomycosis 170.01 124.02 110 26909 38421 110523859
Obesity 166.55 124.02 170 26849 113181 110449099
C-reactive protein abnormal 166.51 124.02 181 26838 129514 110432766
Blood cholesterol increased 166.24 124.02 215 26804 184570 110377710
Blepharospasm 165.52 124.02 124 26895 54727 110507553
Lower respiratory tract infection 162.21 124.02 245 26774 242861 110319419
Back injury 158.48 124.02 114 26905 47285 110514995
Night sweats 158.25 124.02 179 26840 133804 110428476
Onychomadesis 157.67 124.02 112 26907 45551 110516729
Joint range of motion decreased 156.35 124.02 170 26849 121662 110440618
Musculoskeletal pain 155.41 124.02 207 26812 182816 110379464
Rheumatic fever 153.75 124.02 169 26850 122410 110439870
Hypercholesterolaemia 147.75 124.02 144 26875 90693 110471587
Pericarditis 146.40 124.02 221 26798 218893 110343387
Epilepsy 143.05 124.02 148 26871 100061 110462219
Wound infection 142.28 124.02 145 26874 96320 110465960
Lung disorder 136.80 124.02 193 26826 179854 110382426
Hypoaesthesia 128.47 124.02 255 26764 313968 110248312
Wound 125.80 124.02 214 26805 234223 110328057
Systemic lupus erythematosus 124.57 124.02 223 26796 254115 110308165

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AB11 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:50857 anti-allergic drugs
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:88188 allergenic drug

Related Drugs by ATC class:

D07AB Corticosteroids, moderately potent (group II) 12 drugs
alclometasone dipropionateclobetasone butyrateclocortolone pivalatedesonidedexamethasoneflumetasonefluocortin butylfluorometholonefluperolonefluprednidenehydrocortisone butyratetriamcinolone

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
4025074 VUID
N0000179153 NUI
4017941 VANDF
4021000 VANDF
4025074 VANDF
CHEBI:31675 CHEBI
CHEMBL1200953 ChEMBL_ID
DB14543 DRUGBANK_ID
O6550D6K3A UNII
DB00741 DRUGBANK_ID
219083 RXNORM
17268 MMSL
2500 MMSL
4837 MMSL
4839 MMSL
9839 MMSL
d00254 MMSL
002147 NDDF
006405 NDDF
126150008 SNOMEDCT_US
16602005 SNOMEDCT_US
396458002 SNOMEDCT_US
56423005 SNOMEDCT_US
C0063076 UMLSCUI
C0020268 UMLSCUI
636398 PUBCHEM_CID
5754 PUBCHEM_CID
38 INN_ID
C033014 MESH_SUPPLEMENTAL_RECORD_UI
D006854 MESH_DESCRIPTOR_UI
CHEBI:17650 CHEBI
O6550D6K3A INXIGHT DRUGS

Pharmaceutical products:

None