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hydrocortisone probutate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| corticosteroids, except prednisolone derivatives | 4569 | 72590-77-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.23 mg/mL | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,STK33,SYK,TEK,TGFBR1 | 28 | |||
| kinase-selectivity-class | AXL,GRK2,MAP2K6 | 3 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 28, 1997 | FDA | FOUGERA PHARMS |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Lip dry | 254.23 | 78.93 | 225 | 27380 | 100730 | 90500112 |
| Facet joint syndrome | 251.19 | 78.93 | 221 | 27384 | 98168 | 90502674 |
| Bursitis | 219.54 | 78.93 | 234 | 27371 | 131420 | 90469422 |
| Liver injury | 190.73 | 78.93 | 247 | 27358 | 170320 | 90430522 |
| Breast cancer stage III | 190.54 | 78.93 | 177 | 27428 | 84270 | 90516572 |
| Osteoarthritis | 186.22 | 78.93 | 262 | 27343 | 195468 | 90405374 |
| Live birth | 184.67 | 78.93 | 169 | 27436 | 78938 | 90521904 |
| Fibromyalgia | 179.99 | 78.93 | 265 | 27340 | 206004 | 90394838 |
| Dry mouth | 178.99 | 78.93 | 249 | 27356 | 183810 | 90417032 |
| Inflammation | 174.25 | 78.93 | 242 | 27363 | 178350 | 90422492 |
| Folliculitis | 168.94 | 78.93 | 256 | 27349 | 204097 | 90396745 |
| C-reactive protein abnormal | 167.19 | 78.93 | 200 | 27405 | 127229 | 90473613 |
| Injury | 158.56 | 78.93 | 244 | 27361 | 197105 | 90403737 |
| Peripheral venous disease | 155.68 | 78.93 | 158 | 27447 | 83763 | 90517079 |
| Type 2 diabetes mellitus | 150.42 | 78.93 | 242 | 27363 | 203002 | 90397840 |
| Nail disorder | 149.29 | 78.93 | 132 | 27473 | 58935 | 90541907 |
| Onychomycosis | 146.54 | 78.93 | 108 | 27497 | 37268 | 90563574 |
| Muscle injury | 142.70 | 78.93 | 219 | 27386 | 176435 | 90424407 |
| Obesity | 140.68 | 78.93 | 167 | 27438 | 105340 | 90495502 |
| Blepharospasm | 140.31 | 78.93 | 124 | 27481 | 55321 | 90545521 |
| Duodenal ulcer perforation | 139.17 | 78.93 | 245 | 27360 | 221043 | 90379799 |
| Night sweats | 136.92 | 78.93 | 182 | 27423 | 128584 | 90472258 |
| Lung disorder | 134.18 | 78.93 | 195 | 27410 | 149688 | 90451154 |
| Back injury | 133.68 | 78.93 | 112 | 27493 | 46510 | 90554332 |
| Irritable bowel syndrome | 133.45 | 78.93 | 232 | 27373 | 207216 | 90393626 |
| Epilepsy | 133.20 | 78.93 | 144 | 27461 | 82062 | 90518780 |
| Blood cholesterol increased | 132.99 | 78.93 | 232 | 27373 | 207780 | 90393062 |
| Ill-defined disorder | 132.50 | 78.93 | 217 | 27388 | 184674 | 90416168 |
| Musculoskeletal pain | 130.92 | 78.93 | 207 | 27398 | 171044 | 90429798 |
| Onychomadesis | 130.85 | 78.93 | 110 | 27495 | 45888 | 90554954 |
| Impaired healing | 129.18 | 78.93 | 245 | 27360 | 233954 | 90366888 |
| Mobility decreased | 128.18 | 78.93 | 254 | 27351 | 250480 | 90350362 |
| Lower respiratory tract infection | 123.43 | 78.93 | 250 | 27355 | 250409 | 90350433 |
| Psoriatic arthropathy | 121.17 | 78.93 | 235 | 27370 | 228100 | 90372742 |
| Drug ineffective | 121.13 | 78.93 | 147 | 27458 | 1384151 | 89216691 |
| Helicobacter infection | 119.80 | 78.93 | 233 | 27372 | 226617 | 90374225 |
| Hand deformity | 117.78 | 78.93 | 271 | 27334 | 296091 | 90304751 |
| Deep vein thrombosis postoperative | 111.15 | 78.93 | 122 | 27483 | 70687 | 90530155 |
| Joint range of motion decreased | 110.67 | 78.93 | 169 | 27436 | 135474 | 90465368 |
| Hypercholesterolaemia | 109.38 | 78.93 | 144 | 27461 | 100748 | 90500094 |
| C-reactive protein | 108.26 | 78.93 | 84 | 27521 | 31283 | 90569559 |
| Rheumatic fever | 106.01 | 78.93 | 177 | 27428 | 152944 | 90447898 |
| Wheezing | 101.57 | 78.93 | 224 | 27381 | 237856 | 90362986 |
| Wound infection | 100.42 | 78.93 | 142 | 27463 | 106260 | 90494582 |
| Autoimmune disorder | 94.96 | 78.93 | 117 | 27488 | 76627 | 90524215 |
| Hypoaesthesia | 91.06 | 78.93 | 255 | 27350 | 313955 | 90286887 |
| Gait inability | 89.21 | 78.93 | 160 | 27445 | 146296 | 90454546 |
| Adverse reaction | 86.44 | 78.93 | 72 | 27533 | 29640 | 90571202 |
| Glossodynia | 82.53 | 78.93 | 250 | 27355 | 321529 | 90279313 |
| Normal newborn | 81.56 | 78.93 | 63 | 27542 | 23299 | 90577543 |
| Pericarditis | 79.97 | 78.93 | 221 | 27384 | 269930 | 90330912 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Lip dry | 297.34 | 124.02 | 224 | 26795 | 99859 | 110462421 |
| Facet joint syndrome | 286.06 | 124.02 | 216 | 26803 | 96612 | 110465668 |
| Bursitis | 257.98 | 124.02 | 230 | 26789 | 129688 | 110432592 |
| Liver injury | 251.66 | 124.02 | 242 | 26777 | 150171 | 110412109 |
| Osteoarthritis | 249.07 | 124.02 | 263 | 26756 | 182360 | 110379920 |
| Fibromyalgia | 241.77 | 124.02 | 251 | 26768 | 170658 | 110391622 |
| Breast cancer stage III | 241.45 | 124.02 | 180 | 26839 | 78937 | 110483343 |
| Live birth | 239.09 | 124.02 | 170 | 26849 | 69314 | 110492966 |
| Hand deformity | 225.16 | 124.02 | 272 | 26747 | 218234 | 110344046 |
| Folliculitis | 224.25 | 124.02 | 239 | 26780 | 167414 | 110394866 |
| Injury | 223.62 | 124.02 | 245 | 26774 | 177020 | 110385260 |
| Muscle injury | 221.40 | 124.02 | 219 | 26800 | 140588 | 110421692 |
| Inflammation | 211.34 | 124.02 | 248 | 26771 | 192990 | 110369290 |
| Irritable bowel syndrome | 210.66 | 124.02 | 229 | 26790 | 163986 | 110398294 |
| Type 2 diabetes mellitus | 208.17 | 124.02 | 236 | 26783 | 176996 | 110385284 |
| Impaired healing | 197.94 | 124.02 | 242 | 26777 | 196475 | 110365805 |
| Duodenal ulcer perforation | 197.53 | 124.02 | 230 | 26789 | 177470 | 110384810 |
| Helicobacter infection | 194.86 | 124.02 | 231 | 26788 | 181646 | 110380634 |
| Ill-defined disorder | 194.69 | 124.02 | 215 | 26804 | 156638 | 110405642 |
| Nail disorder | 186.15 | 124.02 | 136 | 26883 | 57799 | 110504481 |
| Peripheral venous disease | 185.17 | 124.02 | 158 | 26861 | 83959 | 110478321 |
| Glossodynia | 183.90 | 124.02 | 248 | 26771 | 221756 | 110340524 |
| Mobility decreased | 181.31 | 124.02 | 255 | 26764 | 237167 | 110325113 |
| Psoriatic arthropathy | 178.72 | 124.02 | 230 | 26789 | 196531 | 110365749 |
| Dry mouth | 177.36 | 124.02 | 231 | 26788 | 199717 | 110362563 |
| Pemphigus | 173.62 | 124.02 | 237 | 26782 | 214333 | 110347947 |
| Onychomycosis | 170.01 | 124.02 | 110 | 26909 | 38421 | 110523859 |
| Obesity | 166.55 | 124.02 | 170 | 26849 | 113181 | 110449099 |
| C-reactive protein abnormal | 166.51 | 124.02 | 181 | 26838 | 129514 | 110432766 |
| Blood cholesterol increased | 166.24 | 124.02 | 215 | 26804 | 184570 | 110377710 |
| Blepharospasm | 165.52 | 124.02 | 124 | 26895 | 54727 | 110507553 |
| Lower respiratory tract infection | 162.21 | 124.02 | 245 | 26774 | 242861 | 110319419 |
| Back injury | 158.48 | 124.02 | 114 | 26905 | 47285 | 110514995 |
| Night sweats | 158.25 | 124.02 | 179 | 26840 | 133804 | 110428476 |
| Onychomadesis | 157.67 | 124.02 | 112 | 26907 | 45551 | 110516729 |
| Joint range of motion decreased | 156.35 | 124.02 | 170 | 26849 | 121662 | 110440618 |
| Musculoskeletal pain | 155.41 | 124.02 | 207 | 26812 | 182816 | 110379464 |
| Rheumatic fever | 153.75 | 124.02 | 169 | 26850 | 122410 | 110439870 |
| Hypercholesterolaemia | 147.75 | 124.02 | 144 | 26875 | 90693 | 110471587 |
| Pericarditis | 146.40 | 124.02 | 221 | 26798 | 218893 | 110343387 |
| Epilepsy | 143.05 | 124.02 | 148 | 26871 | 100061 | 110462219 |
| Wound infection | 142.28 | 124.02 | 145 | 26874 | 96320 | 110465960 |
| Lung disorder | 136.80 | 124.02 | 193 | 26826 | 179854 | 110382426 |
| Hypoaesthesia | 128.47 | 124.02 | 255 | 26764 | 313968 | 110248312 |
| Wound | 125.80 | 124.02 | 214 | 26805 | 234223 | 110328057 |
| Systemic lupus erythematosus | 124.57 | 124.02 | 223 | 26796 | 254115 | 110308165 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D07AB11 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, moderately potent (group II) |
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
| CHEBI has role | CHEBI:50857 | anti-allergic drugs |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| CHEBI has role | CHEBI:88188 | allergenic drug |
Related Drugs by ATC class:
D07AB Corticosteroids, moderately potent (group II) 12 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4025074 | VUID |
| N0000179153 | NUI |
| 4017941 | VANDF |
| 4021000 | VANDF |
| 4025074 | VANDF |
| CHEBI:31675 | CHEBI |
| CHEMBL1200953 | ChEMBL_ID |
| DB14543 | DRUGBANK_ID |
| O6550D6K3A | UNII |
| DB00741 | DRUGBANK_ID |
| 219083 | RXNORM |
| 17268 | MMSL |
| 2500 | MMSL |
| 4837 | MMSL |
| 4839 | MMSL |
| 9839 | MMSL |
| d00254 | MMSL |
| 002147 | NDDF |
| 006405 | NDDF |
| 126150008 | SNOMEDCT_US |
| 16602005 | SNOMEDCT_US |
| 396458002 | SNOMEDCT_US |
| 56423005 | SNOMEDCT_US |
| C0063076 | UMLSCUI |
| C0020268 | UMLSCUI |
| 636398 | PUBCHEM_CID |
| 5754 | PUBCHEM_CID |
| 38 | INN_ID |
| C033014 | MESH_SUPPLEMENTAL_RECORD_UI |
| D006854 | MESH_DESCRIPTOR_UI |
| CHEBI:17650 | CHEBI |
| O6550D6K3A | INXIGHT DRUGS |
Pharmaceutical products:
None