hydrocortisone probutate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 4569 72590-77-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrocortisone buteprate
  • hydrocortisone probutate
  • pandel
  • Molecular weight: 488.62
  • Formula: C28H40O7
  • CLOGP: 4.55
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 106.97
  • ALOGS: -5.24
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.23 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Feb. 28, 1997 FDA FOUGERA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
C-reactive protein 55.22 36.82 15 1817 4867 63482323
Deep vein thrombosis postoperative 46.59 36.82 16 1816 11353 63475837
Lip dry 41.78 36.82 16 1816 15454 63471736
Autoimmune disorder 40.15 36.82 16 1816 17161 63470029

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
C-reactive protein 58.29 50.19 15 1820 4964 79737589
Deep vein thrombosis postoperative 51.02 50.19 16 1819 10736 79731817

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AB11 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:50857 anti-allergic drugs
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:88188 allergenic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
4025074 VUID
N0000179153 NUI
4017941 VANDF
4021000 VANDF
4025074 VANDF
CHEBI:31675 CHEBI
CHEBI:17650 CHEBI
CHEMBL1200953 ChEMBL_ID
C033014 MESH_SUPPLEMENTAL_RECORD_UI
DB14543 DRUGBANK_ID
O6550D6K3A UNII
DB00741 DRUGBANK_ID
219083 RXNORM
17268 MMSL
2500 MMSL
4837 MMSL
4839 MMSL
9839 MMSL
d00254 MMSL
002147 NDDF
006405 NDDF
126150008 SNOMEDCT_US
16602005 SNOMEDCT_US
396458002 SNOMEDCT_US
C0063076 UMLSCUI
C0020268 UMLSCUI
636398 PUBCHEM_CID
38 INN_ID
5754 PUBCHEM_CID
D006854 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PANDEL HUMAN PRESCRIPTION DRUG LABEL 1 10337-153 CREAM 1 mg TOPICAL NDA 22 sections
PANDEL HUMAN PRESCRIPTION DRUG LABEL 1 62559-325 CREAM 1 mg TOPICAL NDA 22 sections