hydrocortisone butyrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 3959 13609-67-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrocortisone butyrate
  • Hydrocortisone 17-butyrate
  • laticort
  • Hydrocortisone 17alpha-butyrate
  • Molecular weight: 432.56
  • Formula: C25H36O6
  • CLOGP: 3.48
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 100.90
  • ALOGS: -4.50
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.23 mg/mL Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK 17
kinase-selectivity-class AXL,GRK2,MAP2K6 3
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 3.622 Moderate 0.66
pfas-class PFAS structural alert (1 = True, 0 = False) 0
rat-kpuu-brain Rat brain Kpuu 0.041 % Moderate 0.66

Approvals:

DateAgencyCompanyOrphan
March 31, 1982 FDA PRECISION DERMAT

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Facet joint syndrome 327.16 40.70 301 39523 98088 90490535
Lip dry 273.57 40.70 276 39548 100679 90487944
Duodenal ulcer perforation 215.94 40.70 365 39459 220923 90367700
Peripheral venous disease 201.33 40.70 215 39609 83706 90504917
Folliculitis 200.59 40.70 338 39486 204015 90384608
Joint range of motion decreased 193.52 40.70 267 39557 135376 90453247
Dry mouth 182.69 40.70 306 39518 183753 90404870
Breast cancer stage III 176.03 40.70 201 39623 84246 90504377
Irritable bowel syndrome 171.14 40.70 318 39506 207130 90381493
Helicobacter infection 169.02 40.70 333 39491 226517 90362106
C-reactive protein 168.98 40.70 127 39697 31240 90557383
Inflammation 166.78 40.70 289 39535 178303 90410320
Fibromyalgia 164.93 40.70 312 39512 205957 90382666
Rheumatic fever 161.93 40.70 262 39562 152859 90435764
Type 2 diabetes mellitus 159.50 40.70 305 39519 202939 90385684
Impaired healing 155.75 40.70 328 39496 233871 90354752
Sleep disorder due to general medical condition, insomnia type 155.27 40.70 234 39590 128460 90460163
Bursitis 147.06 40.70 231 39593 131423 90457200
Swollen joint count increased 146.84 40.70 211 39613 110995 90477628
Night sweats 146.70 40.70 228 39596 128538 90460085
Psoriatic arthropathy 145.15 40.70 314 39510 228021 90360602
Hand deformity 144.18 40.70 367 39457 295995 90292628
Sciatica 143.69 40.70 199 39625 101183 90487440
Obesity 143.45 40.70 203 39621 105304 90483319
Stomatitis 141.83 40.70 348 39476 274350 90314273
Blepharospasm 141.76 40.70 147 39677 55298 90533325
Liver injury 140.03 40.70 261 39563 170306 90418317
Lung disorder 136.58 40.70 240 39584 149643 90438980
Deep vein thrombosis postoperative 133.32 40.70 160 39664 70649 90517974
Road traffic accident 133.10 40.70 198 39626 107428 90481195
Glossodynia 129.91 40.70 372 39452 321407 90267216
Anti-cyclic citrullinated peptide antibody positive 128.96 40.70 306 39518 236127 90352496
Muscle injury 128.71 40.70 257 39567 176397 90412226
Cough 124.56 40.70 10 39814 368952 90219671
Hypercholesterolaemia 119.60 40.70 182 39642 100710 90487913
Wound 117.20 40.70 345 39479 302635 90285988
Nail disorder 115.36 40.70 136 39688 58931 90529692
Wound infection 115.07 40.70 184 39640 106218 90482405
Epilepsy 114.44 40.70 160 39664 82046 90506577
Liver disorder 114.12 40.70 197 39627 121072 90467551
Hypotension 112.15 40.70 8 39816 325389 90263234
Product dose omission issue 110.50 40.70 4 39820 291683 90296940
Toxicity to various agents 108.86 40.70 4 39820 287842 90300781
Drug interaction 107.55 40.70 3 39821 276450 90312173
Acute kidney injury 107.25 40.70 9 39815 320378 90268245
Autoimmune disorder 101.83 40.70 146 39678 76598 90512025
Taste disorder 101.28 40.70 130 39694 61416 90527207
Urinary tract infection 101.17 40.70 9 39815 305623 90283000
Wheezing 100.66 40.70 280 39544 237800 90350823
Blood cholesterol increased 100.43 40.70 257 39567 207755 90380868
Lower respiratory tract infection 100.33 40.70 289 39535 250370 90338253
Hepatic enzyme 99.22 40.70 48 39776 5296 90583327
Blister 95.37 40.70 287 39537 254711 90333912
Systemic lupus erythematosus 94.49 40.70 361 39463 361535 90227088
Fall 92.82 40.70 48 39776 481762 90106861
Musculoskeletal pain 92.61 40.70 221 39603 171030 90417593
Rheumatoid factor positive 92.27 40.70 221 39603 171429 90417194
Ill-defined disorder 91.91 40.70 231 39593 184660 90403963
Pericarditis 91.73 40.70 294 39530 269857 90318766
Synovitis 89.44 40.70 333 39491 329419 90259204
Nausea 88.07 40.70 227 39597 1110089 89478534
Hepatic enzyme increased 87.01 40.70 351 39473 360385 90228238
General physical health deterioration 84.42 40.70 344 39480 354771 90233852
Injury 84.28 40.70 233 39591 197116 90391507
Urticaria 84.12 40.70 315 39509 312419 90276204
Gait inability 80.25 40.70 190 39634 146266 90442357
Porphyria acute 79.94 40.70 65 39759 17910 90570713
Discomfort 79.39 40.70 283 39541 274052 90314571
Lower limb fracture 78.51 40.70 137 39687 84876 90503747
Infusion related reaction 78.08 40.70 376 39448 416404 90172219
Osteoarthritis 76.66 40.70 224 39600 195506 90393117
Colitis ulcerative 76.08 40.70 112 39712 60154 90528469
Somnolence 75.44 40.70 4 39820 209080 90379543
Back pain 75.11 40.70 23 39801 317152 90271471
Hypoaesthesia 74.35 40.70 304 39520 313906 90274717
Grip strength decreased 72.60 40.70 139 39685 92437 90496186
Pemphigus 67.89 40.70 304 39520 326560 90262063
Retinitis 66.06 40.70 83 39741 38375 90550248
Sleep disorder 65.79 40.70 214 39610 197816 90390807
Product quality issue 65.79 40.70 122 39702 79203 90509420
Lupus-like syndrome 63.43 40.70 92 39732 48754 90539869
Frequent bowel movements 62.26 40.70 99 39725 56836 90531787
Dehydration 61.01 40.70 7 39817 194440 90394183
Injection site pain 60.60 40.70 4 39820 173695 90414928
Sepsis 60.28 40.70 5 39819 179809 90408814
Drug ineffective 59.71 40.70 361 39463 1383937 89204686
Arthropathy 59.14 40.70 317 39507 365925 90222698
Exostosis 58.94 40.70 93 39731 53041 90535582
Migraine 58.14 40.70 200 39624 190192 90398431
Swelling 57.34 40.70 347 39477 418711 90169912
Death 57.13 40.70 70 39754 456481 90132142
C-reactive protein abnormal 56.91 40.70 153 39671 127276 90461347
X-ray abnormal 56.73 40.70 84 39740 45340 90543283
Dyspnoea 56.14 40.70 199 39625 880756 89707867
Myalgia 55.71 40.70 6 39818 175119 90413504
Neutropenia 53.78 40.70 16 39808 224888 90363735
Mobility decreased 53.38 40.70 235 39589 250499 90338124
Weight increased 52.76 40.70 339 39485 417588 90171035
Drug intolerance 51.64 40.70 355 39469 447236 90141387
Maternal exposure timing unspecified 51.06 40.70 56 39768 22427 90566196
Live birth 48.13 40.70 107 39717 79000 90509623
Haemoglobin decreased 47.99 40.70 7 39817 161949 90426674
Muscle spasms 46.18 40.70 226 39598 251657 90336966
Renal failure 45.74 40.70 3 39821 131004 90457619
Rheumatoid arthritis 44.92 40.70 56 39768 362558 90226065
Dyspepsia 43.90 40.70 188 39636 197972 90390651
Chest discomfort 43.35 40.70 5 39819 138360 90450263
Paraesthesia 43.35 40.70 221 39603 250105 90338518
Laryngitis 43.26 40.70 79 39745 50674 90537949
Drug-induced liver injury 42.91 40.70 111 39713 90207 90498416
Pulmonary embolism 42.86 40.70 4 39820 130816 90457807
Hyperhidrosis 42.52 40.70 5 39819 136300 90452323
White blood cell count decreased 41.60 40.70 11 39813 167098 90421525
Atrial fibrillation 41.43 40.70 5 39819 133606 90455017
Memory impairment 41.31 40.70 184 39640 197060 90391563
Influenza 41.30 40.70 6 39818 139258 90449365
Onychomadesis 40.99 40.70 73 39751 45925 90542698
Musculoskeletal stiffness 40.80 40.70 246 39578 296286 90292337

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Device dislocation 58.61 23.04 19 1761 7812 42611743
Device malfunction 50.17 23.04 19 1761 12308 42607247
Paronychia 30.51 23.04 10 1770 4245 42615310
Hepatic function abnormal 24.60 23.04 19 1761 51548 42568007

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Facet joint syndrome 388.52 36.25 309 41364 96519 110451107
Duodenal ulcer perforation 325.40 36.25 367 41306 177333 110370293
Lip dry 323.78 36.25 282 41391 99801 110447825
Folliculitis 306.52 36.25 346 41327 167307 110380319
Irritable bowel syndrome 276.77 36.25 325 41348 163890 110383736
Helicobacter infection 265.96 36.25 335 41338 181542 110366084
Glossodynia 258.80 36.25 366 41307 221638 110325988
Joint range of motion decreased 256.67 36.25 271 41402 121561 110426065
Fibromyalgia 256.59 36.25 319 41354 170590 110377036
Hand deformity 255.85 36.25 361 41312 218145 110329481
Impaired healing 243.73 36.25 334 41339 196383 110351243
Rheumatic fever 237.73 36.25 261 41412 122318 110425308
Peripheral venous disease 232.54 36.25 217 41456 83900 110463726
Type 2 diabetes mellitus 228.77 36.25 307 41366 176925 110370701
Sleep disorder due to general medical condition, insomnia type 227.87 36.25 238 41435 105405 110442221
Breast cancer stage III 226.25 36.25 208 41465 78909 110468717
Psoriatic arthropathy 224.28 36.25 321 41352 196440 110351186
Swollen joint count increased 220.13 36.25 210 41463 83451 110464175
Muscle injury 214.80 36.25 265 41408 140542 110407084
Anti-cyclic citrullinated peptide antibody positive 213.45 36.25 301 41372 181683 110365943
Dry mouth 208.77 36.25 313 41360 199635 110347991
Liver injury 208.70 36.25 270 41403 150143 110397483
Systemic lupus erythematosus 206.50 36.25 355 41318 253983 110293643
Stomatitis 206.18 36.25 367 41306 269875 110277751
Wound 204.63 36.25 338 41335 234099 110313527
C-reactive protein 200.11 36.25 131 41542 30200 110517426
Inflammation 195.35 36.25 298 41375 192940 110354686
Sciatica 193.60 36.25 205 41468 92194 110455432
Acute kidney injury 189.19 36.25 13 41660 635417 109912209
Deep vein thrombosis postoperative 183.50 36.25 163 41510 59128 110488498
Bursitis 183.01 36.25 235 41438 129683 110417943
Road traffic accident 176.59 36.25 210 41463 107188 110440438
Night sweats 171.16 36.25 231 41442 133752 110413874
Blepharospasm 170.16 36.25 151 41522 54700 110492926
Pemphigus 169.53 36.25 296 41377 214274 110333352
Obesity 165.90 36.25 209 41464 113142 110434484
Drug interaction 165.74 36.25 5 41668 500178 110047448
Hypercholesterolaemia 161.65 36.25 185 41488 90652 110456974
Wound infection 159.20 36.25 189 41484 96276 110451350
Blister 158.42 36.25 297 41376 227079 110320547
Synovitis 152.59 36.25 326 41347 273766 110273860
Pericarditis 151.14 36.25 285 41388 218829 110328797
Ill-defined disorder 148.84 36.25 235 41438 156618 110391008
Lung disorder 146.92 36.25 252 41421 179795 110367831
Blood cholesterol increased 146.05 36.25 255 41418 184530 110363096
Rheumatoid factor positive 145.85 36.25 212 41461 131428 110416198
Toxicity to various agents 145.43 36.25 9 41664 480546 110067080
Discomfort 145.28 36.25 277 41396 214430 110333196
Lower respiratory tract infection 143.27 36.25 296 41377 242810 110304816
Autoimmune disorder 140.19 36.25 147 41526 65336 110482290
Nail disorder 138.45 36.25 138 41535 57797 110489829
Hepatic enzyme increased 138.23 36.25 345 41328 320547 110227079
Infusion related reaction 132.06 36.25 378 41295 380784 110166842
Hypotension 131.99 36.25 20 41653 523829 110023797
Injury 131.55 36.25 238 41435 177027 110370599
Liver disorder 130.66 36.25 210 41463 142033 110405593
Wheezing 125.59 36.25 289 41384 254941 110292685
Cough 124.99 36.25 14 41659 461627 110085999
Arthropathy 123.67 36.25 309 41364 287213 110260413
Epilepsy 120.74 36.25 168 41505 100041 110447585
Taste disorder 117.71 36.25 134 41539 65253 110482373
Urticaria 117.06 36.25 323 41350 318534 110229092
Lower limb fracture 116.74 36.25 143 41530 75205 110472421
Swelling 114.72 36.25 341 41332 350700 110196926
Osteoarthritis 113.04 36.25 227 41446 182396 110365230
Gait inability 112.69 36.25 192 41481 136184 110411442
Musculoskeletal pain 111.50 36.25 226 41447 182797 110364829
Hepatic enzyme 111.06 36.25 49 41624 5114 110542512
Hypoaesthesia 109.15 36.25 312 41361 313911 110233715
Alopecia 107.71 36.25 342 41331 364411 110183215
Grip strength decreased 106.57 36.25 141 41532 80033 110467593
Product dose omission issue 103.78 36.25 4 41669 321778 110225848
Fall 99.05 36.25 52 41621 603430 109944196
Retinitis 96.29 36.25 87 41586 32240 110515386
Lupus-like syndrome 95.31 36.25 96 41577 40696 110506930
Death 94.58 36.25 75 41598 698794 109848832
Sleep disorder 94.46 36.25 222 41451 198422 110349204
Porphyria acute 90.73 36.25 67 41606 18713 110528913
Weight increased 88.26 36.25 352 41321 419292 110128334
Migraine 87.29 36.25 197 41476 171455 110376171
Drug intolerance 86.30 36.25 342 41331 406170 110141456
Neutropenia 86.28 36.25 18 41655 374602 110173024
Somnolence 85.81 36.25 7 41666 297442 110250184
Exostosis 85.81 36.25 96 41577 45860 110501766
Product quality issue 84.86 36.25 124 41549 77175 110470451
X-ray abnormal 84.13 36.25 87 41586 38030 110509596
Maternal exposure during pregnancy 83.58 36.25 248 41425 254635 110292991
Mobility decreased 81.67 36.25 235 41438 237187 110310439
Blood pressure increased 80.70 36.25 4 41669 258369 110289257
General physical health deterioration 77.14 36.25 341 41332 424954 110122672
Abdominal discomfort 76.18 36.25 322 41351 393536 110154090
Joint swelling 75.04 36.25 348 41325 442497 110105129
Sepsis 74.81 36.25 16 41657 327330 110220296
Urinary tract infection 74.46 36.25 16 41657 326266 110221360
C-reactive protein abnormal 72.91 36.25 155 41518 129540 110418086
COVID-19 72.86 36.25 5 41668 245055 110302571
Live birth 71.30 36.25 108 41565 69376 110478250
Disease progression 69.67 36.25 6 41667 244028 110303598
Gastrointestinal disorder 68.74 36.25 224 41449 241728 110305898
Laryngitis 68.13 36.25 82 41591 42329 110505297
Nausea 67.86 36.25 239 41434 1235451 109312175
Maternal exposure timing unspecified 67.44 36.25 59 41614 20954 110526672
Dehydration 67.37 36.25 12 41661 279499 110268127
Colitis ulcerative 66.64 36.25 111 41562 77252 110470374
Musculoskeletal stiffness 64.71 36.25 242 41431 279580 110268046
Lupus vulgaris 63.63 36.25 71 41602 33812 110513814
Renal failure 63.52 36.25 6 41667 226568 110321058
Subcutaneous drug absorption impaired 62.85 36.25 38 41635 7621 110540005
Respiratory failure 62.28 36.25 5 41668 215327 110332299
Memory impairment 62.05 36.25 189 41484 196755 110350871
Anaemia 61.86 36.25 69 41604 547017 110000609
Haemoglobin decreased 61.43 36.25 10 41663 248717 110298909
Dyspepsia 59.92 36.25 183 41490 190782 110356844
Myocardial infarction 59.89 36.25 3 41670 192080 110355546
Dyspnoea 59.45 36.25 216 41457 1106656 109440970
Dislocation of vertebra 58.25 36.25 77 41596 43644 110503982
Back pain 57.87 36.25 34 41639 370962 110176664
Muscle spasms 57.34 36.25 232 41441 277925 110269701
Frequent bowel movements 55.66 36.25 98 41575 71292 110476334
Febrile neutropenia 55.39 36.25 25 41648 316742 110230884
Myalgia 54.79 36.25 9 41664 222372 110325254
Joint dislocation 54.74 36.25 66 41607 34124 110513502
Paraesthesia 54.13 36.25 227 41446 276294 110271332
Hyponatraemia 53.19 36.25 9 41664 217644 110329982
Cerebrovascular accident 53.01 36.25 4 41669 181280 110366346
Pulmonary fibrosis 52.84 36.25 118 41555 101924 110445702
Hypersensitivity 52.64 36.25 295 41378 403703 110143923
Hyperhidrosis 52.39 36.25 5 41668 187293 110360333
Red blood cell sedimentation rate increased 51.62 36.25 100 41573 78202 110469424
Onychomadesis 51.19 36.25 74 41599 45589 110502037
Chills 50.97 36.25 6 41667 190574 110357052
Hip arthroplasty 49.30 36.25 81 41592 55732 110491894
Syncope 48.14 36.25 9 41664 202527 110345099
Nasopharyngitis 47.47 36.25 282 41391 394079 110153547
Pustular psoriasis 47.32 36.25 40 41633 13565 110534061
Sinusitis 46.44 36.25 228 41445 296460 110251166
General symptom 46.00 36.25 33 41640 8813 110538813
C-reactive protein increased 45.88 36.25 183 41490 217736 110329890
Adverse event 45.71 36.25 116 41557 108693 110438933
Cardiac failure 45.32 36.25 8 41665 187618 110360008
Product label confusion 45.14 36.25 49 41624 22628 110524998
Injection site pain 44.27 36.25 7 41666 177915 110369711
Cardiac arrest 44.16 36.25 10 41663 196743 110350883
Loss of consciousness 44.01 36.25 10 41663 196296 110351330
Disability 43.02 36.25 55 41618 30168 110517458
Ear infection 42.43 36.25 81 41592 62651 110484975
Pulmonary embolism 42.33 36.25 14 41659 214460 110333166
Pleural effusion 42.01 36.25 8 41665 177701 110369925
Atrial fibrillation 41.93 36.25 17 41656 229625 110318001
Adjustment disorder with depressed mood 41.92 36.25 66 41607 43817 110503809
White blood cell count decreased 41.85 36.25 17 41656 229373 110318253
Hepatic cirrhosis 41.72 36.25 84 41589 67542 110480084
Rash vesicular 40.84 36.25 38 41635 14614 110533012
Pancytopenia 40.82 36.25 14 41659 209599 110338027
Back injury 40.80 36.25 68 41605 47331 110500295
Dysphagia 40.67 36.25 5 41668 153595 110394031
Female genital tract fistula 40.65 36.25 40 41633 16479 110531147
Drug-induced liver injury 40.42 36.25 118 41555 119949 110427677
Palpitations 40.22 36.25 6 41667 159206 110388420
Swollen joint count 39.78 36.25 30 41643 8644 110538982
Vaginal discharge 39.74 36.25 41 41632 17867 110529759
Prescribed overdose 39.56 36.25 96 41577 87485 110460141
Vaginal flatulence 38.77 36.25 34 41639 12110 110535516
Chest discomfort 38.68 36.25 9 41664 173839 110373787
Blood glucose increased 38.52 36.25 3 41670 132493 110415133
Blood creatinine increased 37.77 36.25 11 41662 182878 110364748
Drug tolerance decreased 37.45 36.25 49 41624 27491 110520135
Drug ineffective 36.96 36.25 381 41292 1520159 109027467
Oropharyngeal pain 36.82 36.25 4 41669 135272 110412354
Bone erosion 36.58 36.25 64 41609 46307 110501319

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AB02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC D07BB04 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, moderately potent, combinations with antiseptics
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D003879 Dermatologic Agents
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:50857 anti-allergic drugs
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:88188 allergenic drug
CHEBI has role CHEBI:50177 dermatologic agent

Related Drugs by ATC class:

D07AB Corticosteroids, moderately potent (group II) 12 drugs
alclometasone dipropionateclobetasone butyrateclocortolone pivalatedesonidedexamethasoneflumetasonefluocortin butylfluorometholonefluperolonefluprednidenehydrocortisone probutatetriamcinolone
D07BB Corticosteroids, moderately potent, combinations with antiseptics 3 drugs
desonideflumetasonetriamcinolone

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.48 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL
Mineralocorticoid receptor Nuclear hormone receptor EC50 8.53 CHEMBL

External reference:

IDSource
4017947 VUID
N0000146297 NUI
D01619 KEGG_DRUG
4017941 VANDF
4017947 VANDF
C0352536 UMLSCUI
CHEBI:31674 CHEBI
CHEMBL1683 ChEMBL_ID
DB14540 DRUGBANK_ID
C007975 MESH_SUPPLEMENTAL_RECORD_UI
05RMF7YPWN UNII
26133 PUBCHEM_CID
DB00741 DRUGBANK_ID
103468 RXNORM
2500 MMSL
4837 MMSL
4840 MMSL
72408 MMSL
d00254 MMSL
002147 NDDF
002149 NDDF
16602005 SNOMEDCT_US
396458002 SNOMEDCT_US
50665003 SNOMEDCT_US
56423005 SNOMEDCT_US
C0020268 UMLSCUI
5754 PUBCHEM_CID
38 INN_ID
D006854 MESH_DESCRIPTOR_UI
CHEBI:17650 CHEBI
05RMF7YPWN INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Locoid HUMAN PRESCRIPTION DRUG LABEL 1 16781-392 LOTION 1 mg TOPICAL NDA 22 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 21695-971 CREAM 1 mg TOPICAL NDA 18 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 51672-4061 SOLUTION 1 mg TOPICAL ANDA 18 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 51672-4074 CREAM 1 mg TOPICAL ANDA 18 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 51672-4083 OINTMENT 1 mg TOPICAL ANDA 18 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 52565-087 LOTION 1 mg TOPICAL ANDA 22 sections
HYDROCORTISONE BUTYRATE HUMAN PRESCRIPTION DRUG LABEL 1 54868-6248 CREAM 1 mg TOPICAL NDA 18 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 68180-951 LOTION 1 mg TOPICAL ANDA 14 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 68682-271 OINTMENT 1 mg TOPICAL NDA 17 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 68682-384 CREAM 1 mg TOPICAL NDA authorized generic 22 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 72162-2630 LOTION 1 mg TOPICAL ANDA 23 sections
Aquax-H HUMAN PRESCRIPTION DRUG LABEL 1 82160-127 CREAM 30 mg TOPICAL unapproved drug other 17 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 83148-012 LOTION 1 mg TOPICAL ANDA 23 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 83148-012 LOTION 1 mg TOPICAL ANDA 23 sections
Evesse HUMAN PRESCRIPTION DRUG LABEL 1 87143-420 LOTION 1 mg TOPICAL ANDA 26 sections