hydrocortisone butyrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 3959 13609-67-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrocortisone butyrate
  • Hydrocortisone 17-butyrate
  • laticort
  • Hydrocortisone 17alpha-butyrate
  • Molecular weight: 432.56
  • Formula: C25H36O6
  • CLOGP: 3.48
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 100.90
  • ALOGS: -4.50
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 31, 1982 FDA PRECISION DERMAT

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug eruption 25.37 20.94 15 2337 23591 50579181
Blood cholesterol 24.25 20.94 5 2347 306 50602466
Rheumatoid factor positive 23.35 20.94 19 2333 49840 50552932
Stomatitis 23.22 20.94 26 2326 101318 50501454
Dermatitis acneiform 22.18 20.94 8 2344 4049 50598723
Paronychia 21.27 20.94 8 2344 4556 50598216

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Paronychia 50.09 23.09 14 1449 2939 29570125
Dermatitis acneiform 45.52 23.09 15 1448 5476 29567588
Hepatic function abnormal 41.00 23.09 25 1438 39234 29533830
Colorectal cancer 27.81 23.09 8 1455 1859 29571205
Cerebellar stroke 26.30 23.09 5 1458 189 29572875

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dermatitis acneiform 67.29 21.63 23 3526 8420 64486763
Paronychia 64.97 21.63 21 3528 6471 64488712
Hepatic function abnormal 46.60 21.63 34 3515 64279 64430904
Stomatitis 38.12 21.63 38 3511 109567 64385616
Colorectal cancer 34.60 21.63 11 3538 3210 64491973
Drug eruption 32.93 21.63 22 3527 36114 64459069
Dry skin 32.48 21.63 25 3524 51136 64444047
Rash 31.19 21.63 74 3475 458475 64036708
Decreased appetite 25.47 21.63 51 3498 281238 64213945
Neutrophil count decreased 25.42 21.63 26 3523 77170 64418013

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AB02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC D07BB04 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, moderately potent, combinations with antiseptics
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D003879 Dermatologic Agents
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:50857 anti-allergic drugs
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:88188 allergenic drug
CHEBI has role CHEBI:50177 dermatologic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.48 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
4017947 VUID
N0000146297 NUI
D01619 KEGG_DRUG
4017941 VANDF
4017947 VANDF
C0352536 UMLSCUI
CHEBI:31674 CHEBI
CHEBI:17650 CHEBI
CHEMBL1683 ChEMBL_ID
DB14540 DRUGBANK_ID
C007975 MESH_SUPPLEMENTAL_RECORD_UI
05RMF7YPWN UNII
26133 PUBCHEM_CID
5754 PUBCHEM_CID
DB00741 DRUGBANK_ID
103468 RXNORM
2500 MMSL
4837 MMSL
4840 MMSL
72408 MMSL
d00254 MMSL
002147 NDDF
002149 NDDF
16602005 SNOMEDCT_US
396458002 SNOMEDCT_US
50665003 SNOMEDCT_US
C0020268 UMLSCUI
38 INN_ID
D006854 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Locoid Lipocream HUMAN PRESCRIPTION DRUG LABEL 1 16781-384 CREAM 1 mg TOPICAL NDA 21 sections
Locoid HUMAN PRESCRIPTION DRUG LABEL 1 16781-392 LOTION 1 mg TOPICAL NDA 22 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 21695-971 CREAM 1 mg TOPICAL NDA 18 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 51672-4061 SOLUTION 1 mg TOPICAL ANDA 18 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 51672-4074 CREAM 1 mg TOPICAL ANDA 18 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 51672-4083 OINTMENT 1 mg TOPICAL ANDA 18 sections
HYDROCORTISONE BUTYRATE HUMAN PRESCRIPTION DRUG LABEL 1 51862-159 LOTION 1 mg TOPICAL ANDA 26 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 52565-087 LOTION 1 mg TOPICAL ANDA 22 sections
HYDROCORTISONE BUTYRATE HUMAN PRESCRIPTION DRUG LABEL 1 54868-6248 CREAM 1 mg TOPICAL NDA 18 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 68180-951 LOTION 1 mg TOPICAL ANDA 14 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 68682-271 OINTMENT 1 mg TOPICAL NDA 17 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 68682-384 CREAM 1 mg TOPICAL NDA authorized generic 21 sections
HYDROCORTISONE BUTYRATE HUMAN PRESCRIPTION DRUG LABEL 1 68682-392 LOTION 1 mg TOPICAL NDA authorized generic 22 sections
Hydrocortisone Butyrate HUMAN PRESCRIPTION DRUG LABEL 1 70512-032 LOTION 1 mg TOPICAL ANDA 14 sections
Aquax-H HUMAN PRESCRIPTION DRUG LABEL 1 82160-127 CREAM 30 mg TOPICAL unapproved drug other 17 sections