All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

hydrocortisone butyrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
corticosteroids, except prednisolone derivatives	3959	13609-67-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: hydrocortisone butyrate Hydrocortisone 17-butyrate laticort Hydrocortisone 17alpha-butyrate	Molecular weight: 432.56 Formula: C25H36O6 CLOGP: 3.48 LIPINSKI: 0 HAC: 6 HDO: 2 TPSA: 100.90 ALOGS: -4.50 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
March 31, 1982	FDA	PRECISION DERMAT

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid factor positive	58.60	22.49	46	4306	69014	56218701
Anti-cyclic citrullinated peptide antibody positive	44.48	22.49	46	4306	98554	56189161
Blood cholesterol	43.15	22.49	10	4342	630	56287085
Pericarditis	42.41	22.49	47	4305	108876	56178839
Dermatitis acneiform	38.58	22.49	14	4338	4330	56283385
Hand deformity	32.95	22.49	46	4306	134446	56153269
Wound	31.83	22.49	46	4306	138758	56148957
Discomfort	31.09	22.49	46	4306	141715	56146000
Glossodynia	29.94	22.49	47	4305	152411	56135304
Rash	27.52	22.49	92	4260	492955	55794760
Pemphigus	27.51	22.49	46	4306	157166	56130549
Duodenal ulcer perforation	27.45	22.49	30	4322	68312	56219403
Vaginal flatulence	27.17	22.49	7	4345	686	56287029
Systemic lupus erythematosus	26.72	22.49	49	4303	180029	56107686
Synovitis	26.64	22.49	46	4306	161259	56126456
Hepatic enzyme increased	25.89	22.49	47	4305	171337	56116378
Infusion related reaction	23.93	22.49	51	4301	208880	56078835
Stomatitis	23.36	22.49	37	4315	120773	56166942

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Paronychia	56.94	22.96	16	1660	3202	31692466
Dermatitis acneiform	55.80	22.96	18	1658	5749	31689919
Hepatic function abnormal	38.33	22.96	25	1651	41197	31654471
Cerebellar stroke	25.96	22.96	5	1671	189	31695479
Stomatitis	22.96	22.96	18	1658	39420	31656248

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dermatitis acneiform	94.15	20.50	32	5006	8913	70914493
Paronychia	65.50	20.50	23	5015	7051	70916355
Stomatitis	44.33	20.50	50	4988	128461	70794945
Rash	43.37	20.50	105	4933	510457	70412949
Rheumatoid factor positive	40.69	20.50	31	5007	48369	70875037
Hepatic function abnormal	37.27	20.50	34	5004	67962	70855444
Anti-cyclic citrullinated peptide antibody positive	32.55	20.50	32	5006	70153	70853253
Dry skin	28.77	20.50	27	5011	55904	70867502
Pemphigus	28.08	20.50	32	5006	83004	70840402
Pericarditis	27.56	20.50	32	5006	84673	70838733
Systemic lupus erythematosus	27.48	20.50	35	5003	101867	70821539
Hand deformity	27.02	20.50	32	5006	86450	70836956
Glossodynia	27.02	20.50	32	5006	86455	70836951
Eczema	26.99	20.50	21	5017	33760	70889646
Drug eruption	26.15	20.50	22	5016	39474	70883932
Wound	23.65	20.50	32	5006	98700	70824706
Neutrophil count decreased	23.00	20.50	29	5009	83527	70839879
Lip dry	22.89	20.50	12	5026	9773	70913633
Discomfort	22.02	20.50	32	5006	105404	70818002
Colorectal cancer	21.58	20.50	11	5027	8459	70914947
Duodenal ulcer perforation	21.30	20.50	22	5016	51090	70872316

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D07AB02	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, moderately potent (group II)
ATC	D07BB04	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS Corticosteroids, moderately potent, combinations with antiseptics
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
FDA EPC	N0000175576	Corticosteroid
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D000893	Anti-Inflammatory Agents
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:49167	anti-asthmatic drugs
CHEBI has role	CHEBI:50857	anti-allergic drugs
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:88188	allergenic drug
CHEBI has role	CHEBI:50177	dermatologic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.48	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST				CHEMBL	CHEMBL

External reference:

ID	Source
4017947	VUID
N0000146297	NUI
D01619	KEGG_DRUG
4017941	VANDF
4017947	VANDF
C0352536	UMLSCUI
CHEBI:31674	CHEBI
CHEBI:17650	CHEBI
CHEMBL1683	ChEMBL_ID
DB14540	DRUGBANK_ID
C007975	MESH_SUPPLEMENTAL_RECORD_UI
05RMF7YPWN	UNII
26133	PUBCHEM_CID
DB00741	DRUGBANK_ID
103468	RXNORM
2500	MMSL
4837	MMSL
4840	MMSL
72408	MMSL
d00254	MMSL
002147	NDDF
002149	NDDF
16602005	SNOMEDCT_US
396458002	SNOMEDCT_US
50665003	SNOMEDCT_US
C0020268	UMLSCUI
38	INN_ID
D006854	MESH_DESCRIPTOR_UI
5754	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Locoid Lipocream	HUMAN PRESCRIPTION DRUG LABEL	1	16781-384	CREAM	1 mg	TOPICAL	NDA	21 sections
Locoid	HUMAN PRESCRIPTION DRUG LABEL	1	16781-392	LOTION	1 mg	TOPICAL	NDA	22 sections
Hydrocortisone Butyrate	HUMAN PRESCRIPTION DRUG LABEL	1	21695-971	CREAM	1 mg	TOPICAL	NDA	18 sections
Hydrocortisone Butyrate	HUMAN PRESCRIPTION DRUG LABEL	1	51672-4061	SOLUTION	1 mg	TOPICAL	ANDA	18 sections
Hydrocortisone Butyrate	HUMAN PRESCRIPTION DRUG LABEL	1	51672-4074	CREAM	1 mg	TOPICAL	ANDA	18 sections
Hydrocortisone Butyrate	HUMAN PRESCRIPTION DRUG LABEL	1	51672-4083	OINTMENT	1 mg	TOPICAL	ANDA	18 sections
HYDROCORTISONE BUTYRATE	HUMAN PRESCRIPTION DRUG LABEL	1	51862-159	LOTION	1 mg	TOPICAL	ANDA	26 sections
Hydrocortisone Butyrate	HUMAN PRESCRIPTION DRUG LABEL	1	52565-087	LOTION	1 mg	TOPICAL	ANDA	22 sections
HYDROCORTISONE BUTYRATE	HUMAN PRESCRIPTION DRUG LABEL	1	54868-6248	CREAM	1 mg	TOPICAL	NDA	18 sections
Hydrocortisone Butyrate	HUMAN PRESCRIPTION DRUG LABEL	1	68180-951	LOTION	1 mg	TOPICAL	ANDA	14 sections
Hydrocortisone Butyrate	HUMAN PRESCRIPTION DRUG LABEL	1	68682-271	OINTMENT	1 mg	TOPICAL	NDA	17 sections
Hydrocortisone Butyrate	HUMAN PRESCRIPTION DRUG LABEL	1	68682-384	CREAM	1 mg	TOPICAL	NDA authorized generic	21 sections
HYDROCORTISONE BUTYRATE	HUMAN PRESCRIPTION DRUG LABEL	1	68682-392	LOTION	1 mg	TOPICAL	NDA authorized generic	22 sections
Hydrocortisone Butyrate	HUMAN PRESCRIPTION DRUG LABEL	1	70512-032	LOTION	1 mg	TOPICAL	ANDA	14 sections
Aquax-H	HUMAN PRESCRIPTION DRUG LABEL	1	82160-127	CREAM	30 mg	TOPICAL	unapproved drug other	17 sections