Stem definition | Drug id | CAS RN |
---|---|---|
corticosteroids, except prednisolone derivatives | 3959 | 13609-67-1 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
March 31, 1982 | FDA | PRECISION DERMAT |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Rheumatoid factor positive | 58.60 | 22.49 | 46 | 4306 | 69014 | 56218701 |
Anti-cyclic citrullinated peptide antibody positive | 44.48 | 22.49 | 46 | 4306 | 98554 | 56189161 |
Blood cholesterol | 43.15 | 22.49 | 10 | 4342 | 630 | 56287085 |
Pericarditis | 42.41 | 22.49 | 47 | 4305 | 108876 | 56178839 |
Dermatitis acneiform | 38.58 | 22.49 | 14 | 4338 | 4330 | 56283385 |
Hand deformity | 32.95 | 22.49 | 46 | 4306 | 134446 | 56153269 |
Wound | 31.83 | 22.49 | 46 | 4306 | 138758 | 56148957 |
Discomfort | 31.09 | 22.49 | 46 | 4306 | 141715 | 56146000 |
Glossodynia | 29.94 | 22.49 | 47 | 4305 | 152411 | 56135304 |
Rash | 27.52 | 22.49 | 92 | 4260 | 492955 | 55794760 |
Pemphigus | 27.51 | 22.49 | 46 | 4306 | 157166 | 56130549 |
Duodenal ulcer perforation | 27.45 | 22.49 | 30 | 4322 | 68312 | 56219403 |
Vaginal flatulence | 27.17 | 22.49 | 7 | 4345 | 686 | 56287029 |
Systemic lupus erythematosus | 26.72 | 22.49 | 49 | 4303 | 180029 | 56107686 |
Synovitis | 26.64 | 22.49 | 46 | 4306 | 161259 | 56126456 |
Hepatic enzyme increased | 25.89 | 22.49 | 47 | 4305 | 171337 | 56116378 |
Infusion related reaction | 23.93 | 22.49 | 51 | 4301 | 208880 | 56078835 |
Stomatitis | 23.36 | 22.49 | 37 | 4315 | 120773 | 56166942 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Paronychia | 56.94 | 22.96 | 16 | 1660 | 3202 | 31692466 |
Dermatitis acneiform | 55.80 | 22.96 | 18 | 1658 | 5749 | 31689919 |
Hepatic function abnormal | 38.33 | 22.96 | 25 | 1651 | 41197 | 31654471 |
Cerebellar stroke | 25.96 | 22.96 | 5 | 1671 | 189 | 31695479 |
Stomatitis | 22.96 | 22.96 | 18 | 1658 | 39420 | 31656248 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Dermatitis acneiform | 94.15 | 20.50 | 32 | 5006 | 8913 | 70914493 |
Paronychia | 65.50 | 20.50 | 23 | 5015 | 7051 | 70916355 |
Stomatitis | 44.33 | 20.50 | 50 | 4988 | 128461 | 70794945 |
Rash | 43.37 | 20.50 | 105 | 4933 | 510457 | 70412949 |
Rheumatoid factor positive | 40.69 | 20.50 | 31 | 5007 | 48369 | 70875037 |
Hepatic function abnormal | 37.27 | 20.50 | 34 | 5004 | 67962 | 70855444 |
Anti-cyclic citrullinated peptide antibody positive | 32.55 | 20.50 | 32 | 5006 | 70153 | 70853253 |
Dry skin | 28.77 | 20.50 | 27 | 5011 | 55904 | 70867502 |
Pemphigus | 28.08 | 20.50 | 32 | 5006 | 83004 | 70840402 |
Pericarditis | 27.56 | 20.50 | 32 | 5006 | 84673 | 70838733 |
Systemic lupus erythematosus | 27.48 | 20.50 | 35 | 5003 | 101867 | 70821539 |
Hand deformity | 27.02 | 20.50 | 32 | 5006 | 86450 | 70836956 |
Glossodynia | 27.02 | 20.50 | 32 | 5006 | 86455 | 70836951 |
Eczema | 26.99 | 20.50 | 21 | 5017 | 33760 | 70889646 |
Drug eruption | 26.15 | 20.50 | 22 | 5016 | 39474 | 70883932 |
Wound | 23.65 | 20.50 | 32 | 5006 | 98700 | 70824706 |
Neutrophil count decreased | 23.00 | 20.50 | 29 | 5009 | 83527 | 70839879 |
Lip dry | 22.89 | 20.50 | 12 | 5026 | 9773 | 70913633 |
Discomfort | 22.02 | 20.50 | 32 | 5006 | 105404 | 70818002 |
Colorectal cancer | 21.58 | 20.50 | 11 | 5027 | 8459 | 70914947 |
Duodenal ulcer perforation | 21.30 | 20.50 | 22 | 5016 | 51090 | 70872316 |
None
Source | Code | Description |
---|---|---|
ATC | D07AB02 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, moderately potent (group II) |
ATC | D07BB04 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS Corticosteroids, moderately potent, combinations with antiseptics |
FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
FDA EPC | N0000175576 | Corticosteroid |
MeSH PA | D003879 | Dermatologic Agents |
MeSH PA | D000893 | Anti-Inflammatory Agents |
CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
CHEBI has role | CHEBI:50857 | anti-allergic drugs |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
CHEBI has role | CHEBI:88188 | allergenic drug |
CHEBI has role | CHEBI:50177 | dermatologic agent |
None
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.48 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
ID | Source |
---|---|
4017947 | VUID |
N0000146297 | NUI |
D01619 | KEGG_DRUG |
4017941 | VANDF |
4017947 | VANDF |
C0352536 | UMLSCUI |
CHEBI:31674 | CHEBI |
CHEBI:17650 | CHEBI |
CHEMBL1683 | ChEMBL_ID |
DB14540 | DRUGBANK_ID |
C007975 | MESH_SUPPLEMENTAL_RECORD_UI |
05RMF7YPWN | UNII |
26133 | PUBCHEM_CID |
DB00741 | DRUGBANK_ID |
103468 | RXNORM |
2500 | MMSL |
4837 | MMSL |
4840 | MMSL |
72408 | MMSL |
d00254 | MMSL |
002147 | NDDF |
002149 | NDDF |
16602005 | SNOMEDCT_US |
396458002 | SNOMEDCT_US |
50665003 | SNOMEDCT_US |
C0020268 | UMLSCUI |
38 | INN_ID |
D006854 | MESH_DESCRIPTOR_UI |
5754 | PUBCHEM_CID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Locoid Lipocream | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16781-384 | CREAM | 1 mg | TOPICAL | NDA | 21 sections |
Locoid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16781-392 | LOTION | 1 mg | TOPICAL | NDA | 22 sections |
Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-971 | CREAM | 1 mg | TOPICAL | NDA | 18 sections |
Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4061 | SOLUTION | 1 mg | TOPICAL | ANDA | 18 sections |
Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4074 | CREAM | 1 mg | TOPICAL | ANDA | 18 sections |
Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4083 | OINTMENT | 1 mg | TOPICAL | ANDA | 18 sections |
HYDROCORTISONE BUTYRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51862-159 | LOTION | 1 mg | TOPICAL | ANDA | 26 sections |
Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52565-087 | LOTION | 1 mg | TOPICAL | ANDA | 22 sections |
HYDROCORTISONE BUTYRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-6248 | CREAM | 1 mg | TOPICAL | NDA | 18 sections |
Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68180-951 | LOTION | 1 mg | TOPICAL | ANDA | 14 sections |
Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68682-271 | OINTMENT | 1 mg | TOPICAL | NDA | 17 sections |
Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68682-384 | CREAM | 1 mg | TOPICAL | NDA authorized generic | 21 sections |
HYDROCORTISONE BUTYRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68682-392 | LOTION | 1 mg | TOPICAL | NDA authorized generic | 22 sections |
Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70512-032 | LOTION | 1 mg | TOPICAL | ANDA | 14 sections |
Aquax-H | HUMAN PRESCRIPTION DRUG LABEL | 1 | 82160-127 | CREAM | 30 mg | TOPICAL | unapproved drug other | 17 sections |