hydrocortisone butyrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| corticosteroids, except prednisolone derivatives | 3959 | 13609-67-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 31, 1982 | FDA | PRECISION DERMAT |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug eruption | 25.37 | 20.94 | 15 | 2337 | 23591 | 50579181 |
| Blood cholesterol | 24.25 | 20.94 | 5 | 2347 | 306 | 50602466 |
| Rheumatoid factor positive | 23.35 | 20.94 | 19 | 2333 | 49840 | 50552932 |
| Stomatitis | 23.22 | 20.94 | 26 | 2326 | 101318 | 50501454 |
| Dermatitis acneiform | 22.18 | 20.94 | 8 | 2344 | 4049 | 50598723 |
| Paronychia | 21.27 | 20.94 | 8 | 2344 | 4556 | 50598216 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Paronychia | 50.09 | 23.09 | 14 | 1449 | 2939 | 29570125 |
| Dermatitis acneiform | 45.52 | 23.09 | 15 | 1448 | 5476 | 29567588 |
| Hepatic function abnormal | 41.00 | 23.09 | 25 | 1438 | 39234 | 29533830 |
| Colorectal cancer | 27.81 | 23.09 | 8 | 1455 | 1859 | 29571205 |
| Cerebellar stroke | 26.30 | 23.09 | 5 | 1458 | 189 | 29572875 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Dermatitis acneiform | 67.29 | 21.63 | 23 | 3526 | 8420 | 64486763 |
| Paronychia | 64.97 | 21.63 | 21 | 3528 | 6471 | 64488712 |
| Hepatic function abnormal | 46.60 | 21.63 | 34 | 3515 | 64279 | 64430904 |
| Stomatitis | 38.12 | 21.63 | 38 | 3511 | 109567 | 64385616 |
| Colorectal cancer | 34.60 | 21.63 | 11 | 3538 | 3210 | 64491973 |
| Drug eruption | 32.93 | 21.63 | 22 | 3527 | 36114 | 64459069 |
| Dry skin | 32.48 | 21.63 | 25 | 3524 | 51136 | 64444047 |
| Rash | 31.19 | 21.63 | 74 | 3475 | 458475 | 64036708 |
| Decreased appetite | 25.47 | 21.63 | 51 | 3498 | 281238 | 64213945 |
| Neutrophil count decreased | 25.42 | 21.63 | 26 | 3523 | 77170 | 64418013 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D07AB02 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, moderately potent (group II) |
| ATC | D07BB04 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS Corticosteroids, moderately potent, combinations with antiseptics |
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D003879 | Dermatologic Agents |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
| CHEBI has role | CHEBI:50857 | anti-allergic drugs |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| CHEBI has role | CHEBI:88188 | allergenic drug |
| CHEBI has role | CHEBI:50177 | dermatologic agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.48 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017947 | VUID |
| N0000146297 | NUI |
| D01619 | KEGG_DRUG |
| 4017941 | VANDF |
| 4017947 | VANDF |
| C0352536 | UMLSCUI |
| CHEBI:31674 | CHEBI |
| CHEBI:17650 | CHEBI |
| CHEMBL1683 | ChEMBL_ID |
| DB14540 | DRUGBANK_ID |
| C007975 | MESH_SUPPLEMENTAL_RECORD_UI |
| 05RMF7YPWN | UNII |
| 26133 | PUBCHEM_CID |
| 5754 | PUBCHEM_CID |
| DB00741 | DRUGBANK_ID |
| 103468 | RXNORM |
| 2500 | MMSL |
| 4837 | MMSL |
| 4840 | MMSL |
| 72408 | MMSL |
| d00254 | MMSL |
| 002147 | NDDF |
| 002149 | NDDF |
| 16602005 | SNOMEDCT_US |
| 396458002 | SNOMEDCT_US |
| 50665003 | SNOMEDCT_US |
| C0020268 | UMLSCUI |
| 38 | INN_ID |
| D006854 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Locoid Lipocream | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16781-384 | CREAM | 1 mg | TOPICAL | NDA | 21 sections |
| Locoid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16781-392 | LOTION | 1 mg | TOPICAL | NDA | 22 sections |
| Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-971 | CREAM | 1 mg | TOPICAL | NDA | 18 sections |
| Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4061 | SOLUTION | 1 mg | TOPICAL | ANDA | 18 sections |
| Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4074 | CREAM | 1 mg | TOPICAL | ANDA | 18 sections |
| Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4083 | OINTMENT | 1 mg | TOPICAL | ANDA | 18 sections |
| HYDROCORTISONE BUTYRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51862-159 | LOTION | 1 mg | TOPICAL | ANDA | 26 sections |
| Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52565-087 | LOTION | 1 mg | TOPICAL | ANDA | 22 sections |
| HYDROCORTISONE BUTYRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-6248 | CREAM | 1 mg | TOPICAL | NDA | 18 sections |
| Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68180-951 | LOTION | 1 mg | TOPICAL | ANDA | 14 sections |
| Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68682-271 | OINTMENT | 1 mg | TOPICAL | NDA | 17 sections |
| Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68682-384 | CREAM | 1 mg | TOPICAL | NDA authorized generic | 21 sections |
| HYDROCORTISONE BUTYRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68682-392 | LOTION | 1 mg | TOPICAL | NDA authorized generic | 22 sections |
| Hydrocortisone Butyrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70512-032 | LOTION | 1 mg | TOPICAL | ANDA | 14 sections |
| Aquax-H | HUMAN PRESCRIPTION DRUG LABEL | 1 | 82160-127 | CREAM | 30 mg | TOPICAL | unapproved drug other | 17 sections |