clocortolone pivalate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids not used as glucocorticosteroids | 4606 | 34097-16-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
topical, anti-inflammatory glucocorticoid; structure
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 22, 1977 | FDA | PROMIUS PHARMA LLC |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D07AB21 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, moderately potent (group II) |
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:59683 | antipruritic drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Atopic dermatitis | indication | 24079001 | DOID:3310 |
| Contact dermatitis | indication | 40275004 | DOID:2773 |
| Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
| Lichen simplex chronicus | indication | 53891004 | |
| Granuloma annulare | indication | 65508009 | DOID:3777 |
| Pruritus ani | indication | 90446007 | |
| Discoid lupus erythematosus | indication | 200938002 | |
| Plaque psoriasis | indication | 200965009 | |
| Scalp psoriasis | indication | 238608008 | |
| Pruritus of genital organs | indication | 267802000 | |
| Eruption of skin | indication | 271807003 | DOID:0050486 |
| Primary cutaneous T-cell lymphoma | indication | 400122007 | |
| Telangiectasia disorder | contraindication | 247479008 | |
| Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
| Atrophoderma | contraindication | 399979006 | |
| Peripheral vascular disease | contraindication | 400047006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.07 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D02287 | KEGG_DRUG |
| 4018552 | VUID |
| N0000146872 | NUI |
| 4018552 | VANDF |
| 4019685 | VANDF |
| CHEBI:59582 | CHEBI |
| CHEMBL1200975 | ChEMBL_ID |
| C007088 | MESH_SUPPLEMENTAL_RECORD_UI |
| C004686 | MESH_SUPPLEMENTAL_RECORD_UI |
| QBL8IZH14X | UNII |
| DB00838 | DRUGBANK_ID |
| 21249 | RXNORM |
| 213051 | MMSL |
| 4472 | MMSL |
| 002182 | NDDF |
| 004948 | NDDF |
| 17503004 | SNOMEDCT_US |
| 35406002 | SNOMEDCT_US |
| 413870009 | SNOMEDCT_US |
| C0055900 | UMLSCUI |
| C0055899 | UMLSCUI |
| CHEMBL2106011 | ChEMBL_ID |
| 5282493 | PUBCHEM_CID |
| 2113 | INN_ID |
| 4828-27-7 | SECONDARY_CAS_RN |
| 5311052 | PUBCHEM_CID |
| N8ZUB7XE0H | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| clocortolone pivalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-341 | CREAM | 0.00 g | TOPICAL | NDA authorized generic | 11 sections |
| Clocortolone Pivalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4166 | CREAM | 0.00 g | TOPICAL | ANDA | 21 sections |
| Clocortolone Pivalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4166 | CREAM | 0.00 g | TOPICAL | ANDA | 21 sections |
| Clocortolone Pivalate Cream | HUMAN PRESCRIPTION DRUG LABEL | 1 | 66993-947 | CREAM | 1 mg | TOPICAL | NDA AUTHORIZED GENERIC | 20 sections |
| Cloderm | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67857-804 | CREAM | 0.00 g | TOPICAL | NDA | 20 sections |
| Cloderm | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71403-804 | CREAM | 1 mg | TOPICAL | NDA | 20 sections |
| Cloderm | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71403-804 | CREAM | 1 mg | TOPICAL | NDA | 20 sections |