rofecoxib Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
selective cyclo-oxygenase inhibitors 2397 162011-90-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • rofecoxib
  • vioxx
  • ceeoxx
a sulfonylphenyl furanone; withdrawn out of concern for TOXICITY
  • Molecular weight: 314.36
  • Formula: C17H14O4S
  • CLOGP: 1.80
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 60.44
  • ALOGS: -4.47
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
25 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.65 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 93 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.13 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
May 20, 1999 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebrovascular accident 8938.30 55.71 1920 4775 18266 2333124
Myocardial infarction 8409.52 55.71 1810 4885 17203 2334187
Coronary artery disease 6625.38 55.71 1233 5462 4706 2346684
Hypertension 6469.13 55.71 1570 5125 25791 2325599
Chest pain 5246.48 55.71 1340 5355 26797 2324593
Depression 3732.67 55.71 1029 5666 27103 2324287
Transient ischaemic attack 2979.21 55.71 639 6056 5339 2346051
Hyperlipidaemia 2875.11 55.71 543 6152 2131 2349259
Cardiac failure congestive 2863.98 55.71 746 5949 15355 2336035
Gastrooesophageal reflux disease 2807.66 55.71 657 6038 8438 2342952
Angina pectoris 2694.32 55.71 549 6146 3438 2347952
Acute myocardial infarction 2541.58 55.71 545 6150 4510 2346880
Anxiety 2186.88 55.71 691 6004 28668 2322722
Dyspnoea 1973.89 55.71 827 5868 77906 2273484
Mitral valve incompetence 1968.11 55.71 393 6302 2157 2349233
Cardiovascular disorder 1877.54 55.71 373 6322 1982 2349408
Cardiac disorder 1788.02 55.71 445 6250 7388 2344002
Osteoarthritis 1738.34 55.71 425 6270 6521 2344869
Angina unstable 1708.71 55.71 316 6379 1050 2350340
Chronic obstructive pulmonary disease 1593.73 55.71 398 6297 6679 2344711
Urinary tract infection 1538.02 55.71 534 6161 29408 2321982
Oedema peripheral 1536.19 55.71 504 6191 23259 2328131
Blood cholesterol increased 1527.76 55.71 363 6332 4878 2346512
Headache 1504.17 55.71 689 6006 79490 2271900
Dizziness 1497.63 55.71 627 6068 58038 2293352
Fall 1399.60 55.71 562 6133 46537 2304853
Anaemia 1370.20 55.71 510 6185 34282 2317108
Ventricular hypertrophy 1344.51 55.71 231 6464 425 2350965
Back pain 1341.73 55.71 490 6205 31169 2320221
Arteriosclerosis 1319.69 55.71 258 6437 1230 2350160
Emotional distress 1289.88 55.71 305 6390 3990 2347400
Thrombosis 1271.28 55.71 351 6344 8793 2342597
Tricuspid valve incompetence 1268.08 55.71 254 6441 1402 2349988
Arteriosclerosis coronary artery 1266.94 55.71 240 6455 933 2350457
Arthropathy 1218.74 55.71 324 6371 6992 2344398
Pulmonary embolism 1183.65 55.71 388 6307 17695 2333695
Carotid artery stenosis 1179.98 55.71 213 6482 587 2350803
Injury 1151.63 55.71 297 6398 5657 2345733
Bronchitis 1147.67 55.71 355 6340 13359 2338031
Hypercholesterolaemia 1112.63 55.71 227 6468 1391 2349999
Atrial fibrillation 1099.82 55.71 344 6351 13424 2337966
Gastritis 1086.06 55.71 269 6426 4312 2347078
Pain in extremity 1047.73 55.71 445 6250 42095 2309295
Cardiomegaly 1045.93 55.71 231 6464 2165 2349225
Renal failure 1045.54 55.71 350 6345 16999 2334391
Palpitations 1019.36 55.71 339 6356 16117 2335273
Drug hypersensitivity 1014.79 55.71 447 6248 46196 2305194
Myocardial ischaemia 992.32 55.71 219 6476 2043 2349347
Lacunar infarction 978.28 55.71 176 6519 471 2350919
Deep vein thrombosis 969.37 55.71 308 6387 12624 2338766
Coronary artery stenosis 968.16 55.71 181 6514 640 2350750
Cerebral infarction 924.10 55.71 235 6460 4202 2347188
Asthenia 906.00 55.71 414 6281 46512 2304878
Coronary artery occlusion 902.96 55.71 183 6512 1075 2350315
Pneumonia 880.23 55.71 412 6283 48884 2302506
Diabetes mellitus 855.39 55.71 247 6448 7248 2344142
Syncope 854.02 55.71 299 6396 16576 2334814
Arthralgia 836.30 55.71 410 6285 53875 2297515
Nausea 824.01 55.71 519 6176 111670 2239720
Hiatus hernia 821.80 55.71 185 6510 1899 2349491
Blood pressure increased 813.77 55.71 289 6406 16697 2334693
Peripheral vascular disorder 807.95 55.71 157 6538 714 2350676
Dyspepsia 805.76 55.71 251 6444 9593 2341797
Insomnia 751.23 55.71 305 6390 25482 2325908
Fatigue 750.58 55.71 443 6252 84430 2266960
Diverticulum 747.61 55.71 161 6534 1318 2350072
Abdominal pain 746.96 55.71 330 6365 34044 2317346
Adverse event 714.31 55.71 216 6479 7443 2343947
Ventricular dysfunction 708.48 55.71 129 6566 376 2351014
Haemorrhoids 708.43 55.71 167 6528 2130 2349260
Arrhythmia 706.69 55.71 203 6492 5825 2345565
Asthma 698.72 55.71 233 6462 11081 2340309
Type 2 diabetes mellitus 689.65 55.71 162 6533 2032 2349358
Hypothyroidism 686.76 55.71 186 6509 4271 2347119
Aortic valve incompetence 682.48 55.71 137 6558 758 2350632
Carpal tunnel syndrome 681.24 55.71 158 6537 1867 2349523
Pain 677.72 55.71 372 6323 61485 2289905
Intervertebral disc degeneration 656.78 55.71 147 6548 1462 2349928
Sleep apnoea syndrome 647.32 55.71 153 6542 1973 2349417
Constipation 640.17 55.71 259 6436 21370 2330020
Hypokalaemia 636.21 55.71 214 6481 10440 2340950
Non-cardiac chest pain 620.56 55.71 125 6570 705 2350685
Upper respiratory tract infection 609.35 55.71 198 6497 8653 2342737
Cataract 604.12 55.71 179 6516 5729 2345661
Hypoaesthesia 601.25 55.71 243 6452 19972 2331418
Hypertensive heart disease 599.16 55.71 109 6586 315 2351075
Ischaemic stroke 595.23 55.71 157 6538 3240 2348150
Neck pain 590.53 55.71 187 6508 7510 2343880
Gastrointestinal haemorrhage 577.21 55.71 207 6488 12228 2339162
Sinusitis 569.32 55.71 221 6474 16305 2335085
Osteoporosis 568.13 55.71 160 6535 4254 2347136
Chest discomfort 566.69 55.71 213 6482 14382 2337008
Cough 564.68 55.71 269 6426 32848 2318542
Spinal osteoarthritis 563.91 55.71 132 6563 1625 2349765
Stress 563.13 55.71 176 6519 6762 2344628
Migraine 553.96 55.71 193 6502 10460 2340930
Rotator cuff syndrome 553.69 55.71 131 6564 1694 2349696
Cardiac murmur 550.79 55.71 128 6567 1523 2349867
Musculoskeletal chest pain 549.28 55.71 137 6558 2239 2349151
Road traffic accident 535.58 55.71 152 6543 4156 2347234
Fibromyalgia 528.15 55.71 142 6553 3158 2348232
Muscle spasms 509.10 55.71 220 6475 21346 2330044
Vomiting 506.17 55.71 325 6370 71277 2280113
Vertigo 503.14 55.71 174 6521 9210 2342180
Cholelithiasis 495.10 55.71 153 6542 5650 2345740
Diarrhoea 488.76 55.71 337 6358 83227 2268163
Hypotension 487.98 55.71 242 6453 32194 2319196
Abdominal pain upper 487.65 55.71 215 6480 21885 2329505
Ischaemic cardiomyopathy 485.62 55.71 93 6602 383 2351007
Rhinitis allergic 482.79 55.71 100 6595 660 2350730
Dyspnoea exertional 480.34 55.71 149 6546 5571 2345819
Heart rate irregular 477.27 55.71 123 6572 2304 2349086
Acute coronary syndrome 477.26 55.71 113 6582 1464 2349926
Dilatation atrial 476.16 55.71 87 6608 259 2351131
Intervertebral disc protrusion 473.14 55.71 128 6567 2913 2348477
Dehydration 463.30 55.71 208 6487 22087 2329303
Ventricular extrasystoles 462.53 55.71 115 6580 1851 2349539
Dyslipidaemia 461.19 55.71 96 6599 651 2350739
Peptic ulcer 458.30 55.71 92 6603 507 2350883
Blood triglycerides increased 437.71 55.71 113 6582 2130 2349260
Contusion 425.43 55.71 167 6528 12643 2338747
Cerebrovascular disorder 423.60 55.71 86 6609 506 2350884
Obesity 423.00 55.71 102 6593 1434 2349956
Sinus bradycardia 409.95 55.71 106 6589 2010 2349380
Joint injury 409.90 55.71 109 6586 2315 2349075
Pulmonary hypertension 407.31 55.71 128 6567 4990 2346400
Oedema 395.83 55.71 149 6546 10054 2341336
Chronic kidney disease 391.22 55.71 118 6577 4000 2347390
Bursitis 391.18 55.71 100 6595 1808 2349582
Irritable bowel syndrome 389.79 55.71 99 6596 1742 2349648
Bradycardia 388.06 55.71 146 6549 9835 2341555
Gallbladder disorder 383.83 55.71 107 6588 2727 2348663
Large intestine polyp 381.31 55.71 88 6607 1010 2350380
Musculoskeletal pain 380.03 55.71 147 6548 10683 2340707
Seizure 377.66 55.71 186 6509 24280 2327110
Dysphagia 376.69 55.71 153 6542 12652 2338738
Cardiomyopathy 375.68 55.71 105 6590 2702 2348688
Acute kidney injury 373.26 55.71 193 6502 27929 2323461
Organ failure 366.73 55.71 73 6622 382 2351008
Cellulitis 366.42 55.71 137 6558 9064 2342326
Back injury 366.31 55.71 83 6612 872 2350518
Carotid artery disease 364.00 55.71 67 6628 210 2351180
Arthritis 359.33 55.71 138 6557 9830 2341560
Overdose 354.52 55.71 167 6528 19740 2331650
Rectal haemorrhage 354.31 55.71 119 6576 5737 2345653
Cardiac arrest 354.01 55.71 153 6542 14777 2336613
Spinal stenosis 353.86 55.71 87 6608 1331 2350059
Gastric disorder 351.04 55.71 106 6589 3604 2347786
Gastric ulcer 350.28 55.71 101 6594 2915 2348475
Paraesthesia 349.98 55.71 171 6524 21917 2329473
Weight increased 348.16 55.71 171 6524 22166 2329224
Prescribed overdose 341.76 55.71 89 6606 1735 2349655
Multiple injuries 341.40 55.71 64 6631 228 2351162
Bundle branch block left 337.07 55.71 78 6617 906 2350484
Cerebral ischaemia 332.61 55.71 80 6615 1110 2350280
Back disorder 332.40 55.71 85 6610 1537 2349853
Weight decreased 329.03 55.71 178 6517 28193 2323197
Tachycardia 327.41 55.71 149 6546 16260 2335130
Cardiac valve disease 327.17 55.71 72 6623 654 2350736
Loss of consciousness 326.61 55.71 155 6540 18612 2332778
Respiratory failure 325.12 55.71 140 6555 13388 2338002
Hemiparesis 323.93 55.71 98 6597 3352 2348038
Pulmonary oedema 323.90 55.71 118 6577 7245 2344145
Meniscus injury 323.36 55.71 77 6618 1021 2350369
Ligament sprain 321.15 55.71 81 6614 1382 2350008
Cardiac failure 319.95 55.71 134 6561 11960 2339430
Diastolic dysfunction 319.26 55.71 69 6626 571 2350819
Sleep disorder 315.50 55.71 112 6583 6377 2345013
Renal disorder 314.78 55.71 102 6593 4386 2347004
Carotid artery occlusion 311.82 55.71 64 6631 400 2350990
Angiopathy 309.52 55.71 70 6625 728 2350662
Aortic arteriosclerosis 309.09 55.71 67 6628 563 2350827
Ventricular tachycardia 301.96 55.71 90 6605 2921 2348469
Vision blurred 301.44 55.71 136 6559 14532 2336858
Amnesia 299.64 55.71 111 6584 7142 2344248
Anxiety disorder 299.41 55.71 63 6632 452 2350938
Stress urinary incontinence 297.75 55.71 59 6636 300 2351090
Neuropathy peripheral 293.44 55.71 124 6571 11308 2340082
Tendonitis 291.97 55.71 82 6613 2145 2349245
Sinus tachycardia 288.91 55.71 89 6606 3236 2348154
Atelectasis 288.14 55.71 79 6616 1886 2349504
Urinary incontinence 287.89 55.71 94 6601 4139 2347251
Pleural effusion 287.68 55.71 123 6572 11545 2339845
Cardio-respiratory arrest 285.02 55.71 114 6581 9032 2342358
Iron deficiency anaemia 282.98 55.71 79 6616 2020 2349370
Supraventricular tachycardia 281.79 55.71 78 6617 1931 2349459
Panic disorder 277.09 55.71 59 6636 451 2350939
Laryngeal pain 274.46 55.71 67 6628 992 2350398
Mitral valve prolapse 272.95 55.71 56 6639 349 2351041
Gastroenteritis 266.23 55.71 82 6613 2978 2348412
Renal cyst 264.42 55.71 66 6629 1076 2350314
Cervicobrachial syndrome 263.56 55.71 48 6647 139 2351251
Radiculopathy 255.86 55.71 59 6636 673 2350717
Intermittent claudication 255.78 55.71 51 6644 269 2351121
Essential hypertension 255.53 55.71 55 6640 445 2350945
Haematoma 254.97 55.71 90 6605 5031 2346359
Mental status changes 254.88 55.71 92 6603 5490 2345900
Drug ineffective 254.52 55.71 251 6444 101373 2250017
Abdominal discomfort 252.06 55.71 127 6568 17329 2334061
Hyperhidrosis 251.79 55.71 122 6573 15300 2336090
Tinnitus 247.13 55.71 88 6607 5047 2346343
Arterial occlusive disease 245.62 55.71 56 6639 605 2350785
Lumbar spinal stenosis 242.66 55.71 56 6639 641 2350749
Nephrolithiasis 242.11 55.71 84 6611 4459 2346931
Rheumatoid arthritis 241.01 55.71 127 6568 19013 2332377
Hyperglycaemia 239.95 55.71 85 6610 4800 2346590
Hyponatraemia 234.47 55.71 111 6584 13214 2338176
Gout 234.34 55.71 63 6632 1392 2349998
Oesophagitis 232.02 55.71 67 6628 1939 2349451
Confusional state 230.91 55.71 134 6561 24210 2327180
Dementia 229.63 55.71 71 6624 2610 2348780
Sciatica 228.21 55.71 67 6628 2058 2349332
Hyperkalaemia 228.02 55.71 86 6609 5807 2345583
Limb injury 225.70 55.71 69 6626 2441 2348949
Ischaemia 225.17 55.71 54 6641 738 2350652
Uterine disorder 224.26 55.71 50 6645 484 2350906
Hypoxia 223.41 55.71 86 6609 6141 2345249
Cerebral atrophy 223.24 55.71 54 6641 767 2350623
Gastrointestinal disorder 222.98 55.71 95 6600 8822 2342568
Diverticulum intestinal 222.60 55.71 52 6643 630 2350760
Balance disorder 221.32 55.71 97 6598 9650 2341740
Osteopenia 221.00 55.71 64 6631 1871 2349519
Chronic fatigue syndrome 220.44 55.71 41 6654 138 2351252
Haematochezia 218.45 55.71 81 6614 5214 2346176
Carotid bruit 213.55 55.71 38 6657 92 2351298
Neck injury 213.36 55.71 44 6651 282 2351108
Gait disturbance 210.85 55.71 123 6572 22422 2328968
Dysuria 210.48 55.71 73 6622 3868 2347522
Dysarthria 208.25 55.71 82 6613 6220 2345170
Diverticulitis 206.53 55.71 73 6622 4092 2347298
Panic attack 206.35 55.71 72 6623 3884 2347506
Intervertebral disc disorder 204.60 55.71 48 6647 593 2350797
Costochondritis 204.11 55.71 43 6652 310 2351080
Glaucoma 198.64 55.71 60 6635 2035 2349355
Blood pressure inadequately controlled 198.30 55.71 50 6645 850 2350540
Supraventricular extrasystoles 198.01 55.71 48 6647 688 2350702
Pyrexia 197.53 55.71 165 6530 53543 2297847
Ventricular fibrillation 195.72 55.71 60 6635 2141 2349249
Coronary artery restenosis 194.86 55.71 34 6661 70 2351320
Leukocytosis 193.90 55.71 67 6628 3509 2347881
Haematuria 192.69 55.71 70 6625 4248 2347142
Sinus disorder 192.28 55.71 62 6633 2616 2348774
Skin laceration 192.19 55.71 62 6633 2620 2348770
Renal artery stenosis 192.03 55.71 39 6656 229 2351161
Major depression 191.08 55.71 50 6645 991 2350399
Acute sinusitis 190.59 55.71 43 6652 441 2350949
Bladder disorder 187.41 55.71 50 6645 1071 2350319
Lumbar radiculopathy 187.13 55.71 39 6656 265 2351125
Upper gastrointestinal haemorrhage 186.38 55.71 57 6638 2017 2349373
Lung neoplasm 185.79 55.71 48 6647 903 2350487
Ventricular hypokinesia 185.05 55.71 44 6651 578 2350812
Goitre 184.08 55.71 47 6648 842 2350548
Pollakiuria 183.05 55.71 65 6630 3691 2347699
Hypersensitivity 182.55 55.71 114 6581 23479 2327911
Aortic valve stenosis 182.55 55.71 39 6656 303 2351087
Low density lipoprotein increased 181.38 55.71 50 6645 1216 2350174
Occult blood positive 180.83 55.71 42 6653 495 2350895
Sinus node dysfunction 180.26 55.71 44 6651 650 2350740
Thyroid disorder 179.49 55.71 52 6643 1521 2349869
Ulcer 178.91 55.71 54 6641 1826 2349564
Exostosis 177.18 55.71 50 6645 1328 2350062
Uterine leiomyoma 175.96 55.71 51 6644 1494 2349896
Foot deformity 175.91 55.71 54 6641 1935 2349455
Aneurysm 173.75 55.71 41 6654 520 2350870
Ejection fraction decreased 173.50 55.71 58 6637 2743 2348647
Rash 172.90 55.71 160 6535 59398 2291992
Aortic aneurysm 172.63 55.71 40 6655 466 2350924
Cerebral artery occlusion 172.11 55.71 35 6660 207 2351183
Nasopharyngitis 171.69 55.71 107 6588 21949 2329441
Head injury 171.09 55.71 63 6632 3971 2347419
Melaena 170.01 55.71 63 6632 4043 2347347
Post-traumatic stress disorder 169.46 55.71 39 6656 440 2350950
Myalgia 168.64 55.71 108 6587 23225 2328165
Duodenal ulcer 168.11 55.71 46 6649 1087 2350303
Cardiogenic shock 167.98 55.71 55 6640 2436 2348954
Visual impairment 167.97 55.71 85 6610 11670 2339720
Bundle branch block right 166.52 55.71 43 6652 807 2350583
Diabetes mellitus inadequate control 165.90 55.71 51 6644 1836 2349554
Nocturia 164.55 55.71 43 6652 847 2350543
Heart rate increased 163.65 55.71 82 6613 11023 2340367
Vertigo positional 162.13 55.71 36 6659 341 2351049
Dementia Alzheimer's type 161.86 55.71 42 6653 804 2350586
Spinal disorder 160.55 55.71 45 6650 1165 2350225
Azotaemia 160.40 55.71 39 6656 566 2350824
Orthostatic hypotension 160.17 55.71 55 6640 2824 2348566
Brain stem infarction 159.93 55.71 33 6662 212 2351178
Decreased appetite 159.18 55.71 113 6582 28778 2322612
Otitis media 158.53 55.71 39 6656 596 2350794
Flank pain 158.36 55.71 47 6648 1498 2349892
Hypovolaemia 156.25 55.71 44 6651 1159 2350231
Abdominal pain lower 155.30 55.71 54 6641 2879 2348511
Tremor 155.16 55.71 98 6597 20563 2330827
Hepatic steatosis 154.26 55.71 55 6640 3158 2348232
Blood glucose increased 152.95 55.71 81 6614 12209 2339181
Embolism 152.44 55.71 44 6651 1269 2350121
Haematemesis 152.16 55.71 58 6637 4024 2347366
Congestive cardiomyopathy 151.75 55.71 41 6654 922 2350468
Pulmonary valve incompetence 151.34 55.71 31 6664 191 2351199
Aortic valve sclerosis 151.26 55.71 30 6665 153 2351237
Epistaxis 149.36 55.71 74 6621 9705 2341685
Nervousness 148.83 55.71 61 6634 5128 2346262
Restless legs syndrome 148.53 55.71 49 6646 2222 2349168
Hypertensive crisis 147.58 55.71 50 6645 2463 2348927
Peripheral venous disease 147.51 55.71 35 6660 455 2350935
Swelling 146.92 55.71 87 6608 16263 2335127
Hernia 146.80 55.71 42 6653 1173 2350217
Coordination abnormal 146.68 55.71 47 6648 1941 2349449
Labyrinthitis 146.19 55.71 33 6662 339 2351051
Duodenitis 145.98 55.71 35 6660 477 2350913
Generalised anxiety disorder 144.42 55.71 30 6665 200 2351190
Diabetic neuropathy 143.87 55.71 34 6661 434 2350956
Emotional disorder 142.48 55.71 47 6648 2130 2349260
Drug intolerance 141.89 55.71 80 6615 13637 2337753
Skin ulcer 141.74 55.71 55 6640 4004 2347386
Muscle strain 141.48 55.71 40 6655 1069 2350321
Mitral valve calcification 140.70 55.71 27 6668 112 2351278
Cystocele 139.13 55.71 29 6666 197 2351193
Gastritis erosive 138.49 55.71 37 6658 796 2350594
Coronary artery thrombosis 138.17 55.71 31 6664 309 2351081
Atrioventricular block first degree 137.63 55.71 38 6657 929 2350461
Staphylococcal infection 137.21 55.71 58 6637 5268 2346122
Hypoxic-ischaemic encephalopathy 136.48 55.71 36 6659 736 2350654
Pericardial effusion 135.31 55.71 53 6642 3956 2347434
Pneumonia aspiration 135.27 55.71 52 6643 3690 2347700
Haemorrhage 135.21 55.71 72 6623 10967 2340423
Fluid retention 134.00 55.71 62 6633 6984 2344406
Anhedonia 133.70 55.71 39 6656 1168 2350222
Plantar fasciitis 133.54 55.71 32 6663 435 2350955
Haemoglobin decreased 133.51 55.71 85 6610 18066 2333324
Breast mass 131.57 55.71 38 6657 1098 2350292
Haematocrit decreased 131.49 55.71 53 6642 4265 2347125
Death 131.18 55.71 160 6535 81308 2270082
Electrocardiogram ST-T change 130.50 55.71 27 6668 176 2351214
Pharyngitis 129.40 55.71 44 6651 2191 2349199
Lung disorder 128.63 55.71 58 6637 6154 2345236
Accelerated hypertension 127.63 55.71 24 6671 87 2351303
Chronic sinusitis 127.48 55.71 32 6663 533 2350857
Bronchospasm 127.37 55.71 47 6648 2977 2348413
Intracranial aneurysm 126.55 55.71 33 6662 644 2350746
Aphasia 124.72 55.71 53 6642 4875 2346515
Emphysema 124.35 55.71 36 6659 1049 2350341
Joint swelling 124.28 55.71 79 6616 16740 2334650
Ear pain 124.22 55.71 45 6650 2704 2348686
Blindness unilateral 123.67 55.71 37 6658 1212 2350178
Pulmonary congestion 122.90 55.71 41 6654 1924 2349466
Sepsis 122.28 55.71 81 6614 18407 2332983
Facial paralysis 122.15 55.71 43 6652 2376 2349014
Memory impairment 121.93 55.71 71 6624 12852 2338538
Lung infiltration 121.07 55.71 42 6653 2222 2349168
Electrocardiogram abnormal 120.88 55.71 37 6658 1311 2350079
Glucose tolerance impaired 120.31 55.71 31 6664 576 2350814
Normochromic normocytic anaemia 119.26 55.71 32 6663 700 2350690
Intracardiac thrombus 119.21 55.71 30 6665 505 2350885
Sudden cardiac death 119.10 55.71 30 6665 507 2350883
Cerebral haemorrhage 119.09 55.71 53 6642 5451 2345939
Cerebral arteriosclerosis 118.96 55.71 22 6673 71 2351319
Nervous system disorder 118.72 55.71 45 6650 3071 2348319
Cerebral thrombosis 118.14 55.71 28 6667 362 2351028
Coagulopathy 118.06 55.71 44 6651 2865 2348525
Silent myocardial infarction 118.04 55.71 22 6673 75 2351315
Cholecystitis 117.64 55.71 41 6654 2199 2349191
Patellofemoral pain syndrome 117.35 55.71 23 6672 109 2351281
Decubitus ulcer 116.04 55.71 36 6659 1335 2350055
Herpes zoster 115.06 55.71 62 6633 9663 2341727
Cerebellar infarction 115.01 55.71 27 6668 334 2351056
Knee arthroplasty 114.04 55.71 43 6652 2892 2348498
Eye disorder 113.73 55.71 44 6651 3175 2348215
Orthopnoea 113.42 55.71 30 6665 620 2350770
Ecchymosis 110.95 55.71 36 6659 1547 2349843
Myofascial pain syndrome 110.49 55.71 23 6672 155 2351235
Scoliosis 109.89 55.71 32 6663 952 2350438
Drug interaction 109.79 55.71 91 6604 29072 2322318
Retinal vein occlusion 109.29 55.71 28 6667 508 2350882
Vasculitis 108.68 55.71 39 6656 2279 2349111
Cystitis 108.36 55.71 50 6645 5592 2345798
Hypertriglyceridaemia 108.35 55.71 31 6664 865 2350525
Foot fracture 108.17 55.71 41 6654 2797 2348593
Malignant hypertension 107.91 55.71 24 6671 229 2351161
Pelvic pain 107.48 55.71 37 6658 1912 2349478
Dilatation ventricular 107.42 55.71 27 6668 452 2350938
Diplopia 107.11 55.71 43 6652 3422 2347968
Ovarian cyst 107.03 55.71 37 6658 1936 2349454
Spondylolisthesis 106.87 55.71 27 6668 462 2350928
Acute respiratory failure 105.46 55.71 41 6654 2997 2348393
Neuralgia 104.79 55.71 40 6655 2782 2348608
Synovial cyst 104.76 55.71 30 6665 840 2350550
Viral infection 104.28 55.71 46 6649 4630 2346760
Hypoacusis 104.13 55.71 42 6653 3383 2348007
Haemorrhagic stroke 103.15 55.71 31 6664 1031 2350359
Breast disorder 102.59 55.71 25 6670 366 2351024
Atrioventricular block complete 102.53 55.71 33 6662 1381 2350009
Rectocele 102.49 55.71 22 6673 175 2351215
Blood urea increased 102.05 55.71 42 6653 3563 2347827
Acute pulmonary oedema 102.01 55.71 32 6663 1231 2350159
Blindness 101.90 55.71 42 6653 3576 2347814
Subarachnoid haemorrhage 100.97 55.71 36 6659 2064 2349326
Treatment noncompliance 99.94 55.71 47 6648 5487 2345903
Thrombophlebitis superficial 99.93 55.71 28 6667 723 2350667
Blood creatinine increased 99.68 55.71 58 6637 10475 2340915
Post procedural complication 99.48 55.71 39 6656 2915 2348475
Electrocardiogram T wave inversion 99.29 55.71 27 6668 622 2350768
Oesophageal stenosis 98.99 55.71 25 6670 427 2350963
Oesophageal disorder 98.56 55.71 25 6670 435 2350955
Malnutrition 98.53 55.71 34 6661 1769 2349621
Increased tendency to bruise 98.17 55.71 33 6662 1585 2349805
Seasonal allergy 97.93 55.71 33 6662 1597 2349793
Liver function test abnormal 97.77 55.71 51 6644 7439 2343951
Pancreatitis 96.93 55.71 52 6643 8027 2343363
Cerebral artery stenosis 96.77 55.71 19 6676 91 2351299
Rectal polyp 96.57 55.71 20 6675 131 2351259
Ischaemic cerebral infarction 96.49 55.71 22 6673 237 2351153
Fungal infection 95.99 55.71 44 6651 4845 2346545
Abdominal distension 95.02 55.71 56 6639 10355 2341035
Atrial flutter 94.82 55.71 30 6665 1187 2350203
Multi-organ disorder 94.48 55.71 22 6673 262 2351128
Carotid arteriosclerosis 94.32 55.71 20 6675 149 2351241
Skin lesion 94.31 55.71 41 6654 3984 2347406
Epigastric discomfort 93.95 55.71 25 6670 529 2350861
Incontinence 93.56 55.71 31 6664 1423 2349967
Blood pressure systolic increased 93.52 55.71 35 6660 2304 2349086
Faeces discoloured 93.23 55.71 35 6660 2324 2349066
Dyspnoea paroxysmal nocturnal 92.61 55.71 19 6676 118 2351272
Productive cough 92.43 55.71 44 6651 5277 2346113
Anaemia postoperative 92.23 55.71 24 6671 464 2350926
Feeling abnormal 91.67 55.71 75 6620 23506 2327884
Extrasystoles 91.49 55.71 28 6667 991 2350399
Hyperthyroidism 89.80 55.71 33 6662 2064 2349326
Tension headache 89.74 55.71 24 6671 518 2350872
Blood potassium decreased 89.51 55.71 43 6652 5262 2346128
Heart valve incompetence 89.11 55.71 22 6673 341 2351049
Hot flush 88.23 55.71 47 6648 7152 2344238
Umbilical hernia 88.22 55.71 22 6673 356 2351034
Clostridium colitis 88.06 55.71 21 6674 279 2351111
Respiratory distress 87.83 55.71 42 6653 5087 2346303
Abdominal hernia 87.28 55.71 24 6671 577 2350813
Anaemia of chronic disease 86.68 55.71 20 6675 228 2351162
Systemic lupus erythematosus 86.05 55.71 39 6656 4182 2347208
Vaginal haemorrhage 85.95 55.71 41 6654 4939 2346451
Varicose vein 85.83 55.71 25 6670 744 2350646
Depressed level of consciousness 85.81 55.71 47 6648 7557 2343833
Dermatitis 85.73 55.71 33 6662 2347 2349043
Joint dislocation 85.58 55.71 29 6666 1427 2349963
Musculoskeletal discomfort 85.51 55.71 32 6663 2106 2349284
Dysfunctional uterine bleeding 85.45 55.71 19 6676 181 2351209
Pleuritic pain 85.38 55.71 24 6671 627 2350763
Cardiac flutter 85.09 55.71 24 6671 635 2350755
Chondromalacia 85.07 55.71 16 6679 58 2351332
Respiratory disorder 84.82 55.71 38 6657 3966 2347424
Skin abrasion 84.62 55.71 27 6668 1098 2350292
Wrist fracture 84.59 55.71 30 6665 1693 2349697
Bronchitis chronic 84.41 55.71 22 6673 428 2350962
Urosepsis 84.18 55.71 31 6664 1950 2349440
Labile hypertension 84.03 55.71 16 6679 63 2351327
Onychomycosis 84.00 55.71 23 6672 544 2350846
Functional gastrointestinal disorder 83.47 55.71 22 6673 448 2350942
Appendix disorder 83.30 55.71 19 6676 205 2351185
Cyst 83.03 55.71 29 6666 1564 2349826
Lower gastrointestinal haemorrhage 82.93 55.71 26 6669 998 2350392
Haemoptysis 82.86 55.71 36 6659 3491 2347899
Helicobacter infection 82.41 55.71 23 6672 585 2350805
Barrett's oesophagus 82.05 55.71 20 6675 293 2351097
Wheezing 81.97 55.71 43 6652 6341 2345049
Gastric haemorrhage 81.73 55.71 26 6669 1047 2350343
Duodenal ulcer haemorrhage 81.34 55.71 21 6674 393 2350997
Pneumonitis 81.33 55.71 37 6658 4002 2347388
Influenza 81.27 55.71 55 6640 12923 2338467
Pleurisy 81.22 55.71 27 6668 1252 2350138
Sinus congestion 80.12 55.71 30 6665 1977 2349413
Hypomagnesaemia 79.86 55.71 32 6663 2532 2348858
Pulmonary fibrosis 78.96 55.71 32 6663 2608 2348782
Peripheral arterial occlusive disease 78.55 55.71 22 6673 567 2350823
Electrocardiogram T wave abnormal 78.52 55.71 20 6675 354 2351036
Bronchial hyperreactivity 78.03 55.71 18 6677 205 2351185
Musculoskeletal disorder 76.83 55.71 31 6664 2497 2348893
Thalamic infarction 76.71 55.71 16 6679 109 2351281
Night sweats 76.64 55.71 34 6661 3466 2347924
Hypoglycaemia 76.12 55.71 45 6650 8362 2343028
Hepatic cyst 75.97 55.71 22 6673 641 2350749
Duodenal ulcer perforation 75.70 55.71 19 6676 316 2351074
Obstructive airways disorder 75.44 55.71 26 6669 1347 2350043
Colitis 75.17 55.71 38 6657 5188 2346202
Gastric ulcer haemorrhage 75.06 55.71 23 6672 817 2350573
Flatulence 74.28 55.71 36 6659 4489 2346901
Lipoma 74.13 55.71 19 6676 345 2351045
Compression fracture 73.35 55.71 23 6672 883 2350507
Concussion 73.08 55.71 23 6672 894 2350496
Visual field defect 72.92 55.71 26 6669 1490 2349900
Anaphylactic reaction 72.65 55.71 46 6649 9659 2341731
Hypertonic bladder 72.64 55.71 19 6676 375 2351015
Mental disorder 72.24 55.71 34 6661 3973 2347417
Vascular dementia 71.81 55.71 15 6680 103 2351287
Visual acuity reduced 71.78 55.71 37 6658 5261 2346129
Subclavian artery stenosis 71.78 55.71 13 6682 36 2351354
Thyroid neoplasm 71.52 55.71 21 6674 643 2350747
Arteriospasm coronary 70.88 55.71 21 6674 664 2350726
Fibrocystic breast disease 70.86 55.71 17 6678 232 2351158
Helicobacter gastritis 70.79 55.71 17 6678 233 2351157
Embolic stroke 70.43 55.71 21 6674 679 2350711
Hemianopia homonymous 70.03 55.71 16 6679 174 2351216
Dermatitis contact 69.97 55.71 25 6670 1441 2349949
Hip fracture 69.93 55.71 35 6660 4677 2346713
Cardiac aneurysm 69.80 55.71 15 6680 120 2351270
Somnolence 69.60 55.71 64 6631 23421 2327969
Rib fracture 69.38 55.71 29 6666 2556 2348834
Wound infection 69.16 55.71 24 6671 1269 2350121
Mitral valve disease 68.88 55.71 18 6677 354 2351036
Vascular pseudoaneurysm 68.58 55.71 17 6678 268 2351122
Intervertebral disc displacement 68.51 55.71 14 6681 85 2351305
Radius fracture 68.38 55.71 20 6675 604 2350786
Vertebral artery stenosis 68.34 55.71 12 6683 26 2351364
Microcytic anaemia 68.08 55.71 19 6676 483 2350907
Spinal compression fracture 67.86 55.71 26 6669 1825 2349565
Liver disorder 67.85 55.71 38 6657 6376 2345014
Aortic stenosis 67.75 55.71 20 6675 624 2350766
Speech disorder 67.57 55.71 38 6657 6426 2344964
Meningioma 67.57 55.71 20 6675 630 2350760
Cerumen impaction 67.20 55.71 16 6679 211 2351179
Retinal haemorrhage 67.11 55.71 23 6672 1171 2350219
Hypertensive cardiomyopathy 66.78 55.71 13 6682 59 2351331
Macular degeneration 66.57 55.71 23 6672 1200 2350190
Helicobacter test positive 66.42 55.71 14 6681 101 2351289
Urge incontinence 66.18 55.71 15 6680 157 2351233
Herpes simplex 65.66 55.71 22 6673 1045 2350345
Pneumothorax 65.64 55.71 27 6668 2285 2349105
Hypokinesia 65.60 55.71 25 6670 1729 2349661
Diabetic retinopathy 65.21 55.71 17 6678 331 2351059
Ulcer haemorrhage 65.21 55.71 19 6676 566 2350824
Vitamin B12 deficiency 65.05 55.71 19 6676 571 2350819
Faecaloma 64.89 55.71 21 6674 894 2350496
Hepatomegaly 64.85 55.71 25 6670 1784 2349606
Arterial stenosis 64.81 55.71 14 6681 115 2351275
Upper limb fracture 64.63 55.71 28 6667 2695 2348695
Epicondylitis 64.27 55.71 16 6679 257 2351133
Sudden death 64.18 55.71 25 6670 1835 2349555
Eye haemorrhage 64.14 55.71 23 6672 1340 2350050
Infarction 64.05 55.71 19 6676 603 2350787
Periarthritis 63.95 55.71 17 6678 358 2351032
Migraine without aura 63.91 55.71 12 6683 43 2351347
Thrombophlebitis 63.75 55.71 20 6675 769 2350621
Disturbance in attention 63.74 55.71 35 6660 5650 2345740
Nerve compression 63.60 55.71 21 6674 953 2350437
Infection 63.11 55.71 54 6641 17975 2333415
Coma 63.02 55.71 41 6654 9015 2342375
Musculoskeletal stiffness 62.94 55.71 46 6649 12201 2339189
Craniocerebral injury 62.65 55.71 17 6678 388 2351002
Micturition urgency 62.15 55.71 22 6673 1234 2350156
Phlebitis 62.11 55.71 21 6674 1026 2350364
Joint effusion 61.81 55.71 22 6673 1254 2350136
Ear infection 61.42 55.71 29 6666 3412 2347978
Pericarditis 61.40 55.71 23 6672 1517 2349873
Breast cancer 61.25 55.71 41 6654 9454 2341936
Left ventricular failure 61.16 55.71 19 6676 707 2350683
Seborrhoeic keratosis 61.02 55.71 16 6679 319 2351071
Haemorrhoidal haemorrhage 60.84 55.71 18 6677 566 2350824
Pyelonephritis 60.77 55.71 25 6670 2116 2349274
International normalised ratio increased 60.53 55.71 37 6658 7299 2344091
Vertebrobasilar insufficiency 60.08 55.71 11 6684 33 2351357
Disorientation 60.02 55.71 35 6660 6337 2345053
Bundle branch block 59.79 55.71 14 6681 171 2351219
Menopausal symptoms 59.14 55.71 16 6679 361 2351029
Amaurosis fugax 58.93 55.71 13 6682 119 2351271
Microangiopathy 58.91 55.71 14 6681 183 2351207
Sacroiliitis 58.70 55.71 15 6680 269 2351121
Tenosynovitis 58.58 55.71 17 6678 499 2350891
Deafness 58.36 55.71 26 6669 2675 2348715
Conjunctivitis 58.08 55.71 25 6670 2368 2349022
Polyp 57.93 55.71 18 6677 670 2350720
Heart injury 57.88 55.71 15 6680 285 2351105
Iliac artery stenosis 57.83 55.71 10 6685 19 2351371
Embolic cerebral infarction 57.62 55.71 13 6682 133 2351257
Parkinson's disease 57.25 55.71 21 6674 1305 2350085
Ileus 57.06 55.71 24 6671 2148 2349242
Toxicity to various agents 56.83 55.71 67 6628 32687 2318703
Phlebitis superficial 56.75 55.71 12 6683 88 2351302
Rhinitis 56.72 55.71 20 6675 1109 2350281
Gastroenteritis viral 56.71 55.71 25 6670 2509 2348881
Inner ear disorder 55.88 55.71 13 6682 154 2351236
Limb discomfort 55.81 55.71 27 6668 3352 2348038
Mitral valve stenosis 55.80 55.71 13 6682 155 2351235
Coronary artery insufficiency 55.79 55.71 11 6684 54 2351336

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 10584.11 56.54 2471 3610 24703 1715997
Coronary artery disease 9767.54 56.54 1952 4129 7894 1732806
Hypertension 5723.28 56.54 1441 4640 18007 1722693
Cerebrovascular accident 5355.94 56.54 1346 4735 16520 1724180
Chest pain 5111.14 56.54 1326 4755 18588 1722112
Acute myocardial infarction 4254.63 56.54 977 5104 7610 1733090
Hyperlipidaemia 3688.43 56.54 692 5389 1537 1739163
Depression 3185.84 56.54 887 5194 15782 1724918
Angina pectoris 2774.77 56.54 628 5453 4390 1736310
Angina unstable 2492.44 56.54 497 5584 1661 1739039
Gastrooesophageal reflux disease 2477.05 56.54 565 5516 4082 1736618
Cardiac failure congestive 2159.99 56.54 646 5435 14624 1726076
Arteriosclerosis coronary artery 2070.09 56.54 417 5664 1475 1739225
Anxiety 2019.03 56.54 616 5465 14911 1725789
Transient ischaemic attack 1878.63 56.54 455 5626 4336 1736364
Mitral valve incompetence 1857.73 56.54 383 5698 1559 1739141
Cardiac disorder 1754.36 56.54 474 5607 7217 1733483
Blood cholesterol increased 1753.90 56.54 395 5686 2631 1738069
Coronary artery stenosis 1694.95 56.54 343 5738 1239 1739461
Arteriosclerosis 1682.74 56.54 350 5731 1497 1739203
Coronary artery occlusion 1644.15 56.54 350 5731 1713 1738987
Cardiovascular disorder 1624.54 56.54 360 5721 2197 1738503
Hypercholesterolaemia 1490.59 56.54 295 5786 917 1739783
Dyspnoea 1472.93 56.54 673 5408 51386 1689314
Osteoarthritis 1461.84 56.54 324 5757 1972 1738728
Emotional distress 1373.06 56.54 297 5784 1581 1739119
Ventricular hypertrophy 1360.73 56.54 257 5824 569 1740131
Sleep apnoea syndrome 1326.98 56.54 296 5785 1858 1738842
Myocardial ischaemia 1303.59 56.54 314 5767 2879 1737821
Chronic obstructive pulmonary disease 1256.77 56.54 346 5735 5607 1735093
Arthropathy 1247.96 56.54 297 5784 2570 1738130
Dizziness 1217.09 56.54 522 5559 33839 1706861
Injury 1207.46 56.54 291 5790 2669 1738031
Carotid artery stenosis 1154.22 56.54 223 5858 582 1740118
Back pain 1134.09 56.54 407 5674 16206 1724494
Atrial fibrillation 1133.05 56.54 397 5684 14714 1725986
Tricuspid valve incompetence 1039.81 56.54 220 5861 1026 1739674
Ventricular dysfunction 985.58 56.54 188 5893 445 1740255
Cardiomegaly 979.57 56.54 235 5846 2099 1738601
Thrombosis 964.13 56.54 297 5784 7224 1733476
Oedema peripheral 929.88 56.54 346 5735 15204 1725496
Headache 922.29 56.54 431 5650 33945 1706755
Ischaemic cardiomyopathy 896.81 56.54 192 5889 955 1739745
Bronchitis 861.59 56.54 253 5828 5179 1735521
Rotator cuff syndrome 850.13 56.54 177 5904 748 1739952
Dyspepsia 842.73 56.54 244 5837 4741 1735959
Benign prostatic hyperplasia 837.06 56.54 188 5893 1210 1739490
Diabetes mellitus 822.52 56.54 258 5823 6650 1734050
Peripheral vascular disorder 816.87 56.54 167 5914 631 1740069
Gastritis 791.14 56.54 210 5871 2907 1737793
Haemorrhoids 787.61 56.54 188 5893 1633 1739067
Dyslipidaemia 770.39 56.54 160 5921 665 1740035
Arrhythmia 746.46 56.54 232 5849 5784 1734916
Intervertebral disc protrusion 742.13 56.54 173 5908 1340 1739360
Ventricular tachycardia 727.20 56.54 205 5876 3593 1737107
Pulmonary embolism 726.36 56.54 276 5805 12783 1727917
Diverticulum 716.31 56.54 156 5925 850 1739850
Hypoaesthesia 706.25 56.54 251 5830 9584 1731116
Anaemia 695.28 56.54 339 5742 29118 1711582
Hiatus hernia 691.12 56.54 152 5929 873 1739827
Pain in extremity 686.65 56.54 292 5789 18180 1722520
Erectile dysfunction 684.20 56.54 203 5878 4294 1736406
Blood pressure increased 680.64 56.54 250 5831 10503 1730197
Arthralgia 679.38 56.54 311 5770 23133 1717567
Syncope 641.27 56.54 258 5823 13911 1726789
Chest discomfort 633.60 56.54 215 5866 7116 1733584
Insomnia 633.51 56.54 266 5815 16010 1724690
Fatigue 632.06 56.54 382 5699 50399 1690301
Renal failure 612.39 56.54 276 5805 19741 1720959
Type 2 diabetes mellitus 609.49 56.54 154 5927 1724 1738976
Aortic valve incompetence 609.35 56.54 130 5951 630 1740070
Fall 605.11 56.54 301 5780 26913 1713787
Sinus bradycardia 605.07 56.54 154 5927 1779 1738921
Back injury 597.34 56.54 124 5957 512 1740188
Intervertebral disc degeneration 590.56 56.54 123 5958 518 1740182
Back disorder 586.79 56.54 132 5949 852 1739848
Palpitations 577.50 56.54 197 5884 6617 1734083
Lacunar infarction 576.63 56.54 119 5962 474 1740226
Acute coronary syndrome 574.90 56.54 154 5927 2201 1738499
Ventricular extrasystoles 560.71 56.54 145 5936 1791 1738909
Pain 557.54 56.54 283 5798 26374 1714326
Carpal tunnel syndrome 544.26 56.54 118 5963 625 1740075
Large intestine polyp 540.05 56.54 123 5958 845 1739855
Cardiac arrest 526.16 56.54 232 5849 15698 1725002
Spinal osteoarthritis 521.14 56.54 115 5966 670 1740030
Asthenia 520.03 56.54 295 5786 34375 1706325
Pneumonia 516.39 56.54 325 5756 45857 1694843
Nephrolithiasis 515.70 56.54 159 5922 3833 1736867
Dilatation atrial 514.30 56.54 99 5982 248 1740452
Deep vein thrombosis 512.40 56.54 199 5882 9721 1730979
Adverse event 511.72 56.54 164 5917 4504 1736196
Road traffic accident 509.71 56.54 154 5927 3459 1737241
Hypertensive heart disease 503.38 56.54 102 5979 362 1740338
Cough 478.61 56.54 230 5851 18967 1721733
Upper respiratory tract infection 478.26 56.54 151 5930 3942 1736758
Sinusitis 473.67 56.54 159 5922 5064 1735636
Bradycardia 469.49 56.54 190 5891 10344 1730356
Blood triglycerides increased 463.94 56.54 133 5948 2467 1738233
Musculoskeletal pain 462.23 56.54 155 5926 4919 1735781
Coronary artery restenosis 456.45 56.54 86 5995 183 1740517
Musculoskeletal chest pain 449.14 56.54 113 5968 1237 1739463
Cardiac murmur 445.14 56.54 110 5971 1112 1739588
Cerebral infarction 434.66 56.54 149 5932 5060 1735640
Gastrointestinal haemorrhage 423.46 56.54 193 5888 14074 1726626
Cellulitis 421.67 56.54 154 5927 6314 1734386
Intermittent claudication 416.40 56.54 86 5995 343 1740357
Joint injury 411.46 56.54 101 5980 990 1739710
Non-cardiac chest pain 410.73 56.54 88 5993 435 1740265
Ventricular fibrillation 408.04 56.54 122 5959 2634 1738066
Dyspnoea exertional 406.32 56.54 134 5947 4027 1736673
Neck pain 400.63 56.54 126 5955 3240 1737460
Hypotension 397.66 56.54 235 5846 29419 1711281
Heart rate irregular 395.48 56.54 107 5974 1585 1739115
Gout 392.45 56.54 117 5964 2499 1738201
Obesity 392.30 56.54 97 5984 982 1739718
Rhinitis allergic 391.85 56.54 80 6001 297 1740403
Arterial occlusive disease 391.34 56.54 91 5990 691 1740009
Cataract 389.41 56.54 120 5961 2878 1737822
Renal cyst 385.70 56.54 95 5986 945 1739755
Carotid artery disease 374.18 56.54 69 6012 123 1740577
Overdose 370.55 56.54 185 5896 16516 1724184
Spinal stenosis 368.80 56.54 84 5997 575 1740125
Organ failure 366.65 56.54 78 6003 370 1740330
Coronary artery thrombosis 359.17 56.54 80 6001 488 1740212
Radiculopathy 359.09 56.54 77 6004 382 1740318
Cardiomyopathy 356.72 56.54 110 5971 2642 1738058
Seizure 354.77 56.54 192 5889 20249 1720451
Pleural effusion 353.82 56.54 158 5923 10952 1729748
Multiple injuries 346.57 56.54 71 6010 269 1740431
Abdominal pain 345.76 56.54 192 5889 21298 1719402
Ejection fraction decreased 334.89 56.54 100 5981 2145 1738555
Hernia 334.34 56.54 88 5993 1164 1739536
Aortic aneurysm 332.89 56.54 84 5997 929 1739771
Pulmonary hypertension 327.66 56.54 103 5978 2639 1738061
Peptic ulcer 323.23 56.54 72 6009 439 1740261
Atelectasis 322.85 56.54 94 5987 1840 1738860
Chronic kidney disease 311.89 56.54 111 5970 4206 1736494
Ischaemic stroke 303.31 56.54 101 5980 3121 1737579
Limb injury 301.90 56.54 83 5998 1307 1739393
Angiopathy 297.25 56.54 71 6010 612 1740088
Pulmonary oedema 297.04 56.54 120 5961 6466 1734234
Constipation 291.27 56.54 152 5929 14848 1725852
Carotid artery occlusion 289.93 56.54 63 6018 336 1740364
Abdominal discomfort 288.45 56.54 129 5952 8952 1731748
Meniscus injury 285.90 56.54 62 6019 327 1740373
Contusion 282.34 56.54 109 5972 5200 1735500
Nausea 279.47 56.54 234 5847 50962 1689738
Muscle spasms 279.00 56.54 136 5945 11485 1729215
Skin laceration 277.96 56.54 84 5997 1877 1738823
Bursitis 273.15 56.54 66 6015 600 1740100
Bundle branch block right 272.22 56.54 75 6006 1190 1739510
Rectal haemorrhage 270.76 56.54 107 5974 5435 1735265
Gastric ulcer 268.03 56.54 88 5993 2597 1738103
Abdominal pain upper 267.83 56.54 130 5951 10871 1729829
Asthma 265.44 56.54 102 5979 4802 1735898
Urinary tract infection 262.36 56.54 125 5956 10028 1730672
Cholelithiasis 261.60 56.54 90 5991 3075 1737625
Stress 261.38 56.54 86 5995 2555 1738145
Aortic arteriosclerosis 260.49 56.54 61 6020 478 1740222
Arthritis 260.03 56.54 95 5986 3880 1736820
Cardiac failure 259.78 56.54 133 5948 12469 1728231
Ventricular hypokinesia 258.21 56.54 64 6017 653 1740047
Lumbar radiculopathy 257.28 56.54 48 6033 94 1740606
Diastolic dysfunction 252.43 56.54 59 6022 458 1740242
Cerebrovascular disorder 252.43 56.54 59 6022 458 1740242
Drug hypersensitivity 250.60 56.54 138 5943 14997 1725703
Cardio-respiratory arrest 247.99 56.54 117 5964 9176 1731524
Prescribed overdose 247.32 56.54 75 6006 1695 1739005
Gastric disorder 247.18 56.54 76 6005 1802 1738898
Blood glucose increased 245.40 56.54 121 5960 10463 1730237
Dilatation ventricular 245.38 56.54 59 6022 524 1740176
Neck injury 244.52 56.54 49 6032 161 1740539
Weight increased 243.16 56.54 123 5958 11234 1729466
Diabetic neuropathy 241.90 56.54 57 6024 460 1740240
Gallbladder disorder 241.79 56.54 66 6015 1009 1739691
Hyperhidrosis 240.69 56.54 126 5955 12362 1728338
Respiratory failure 239.41 56.54 132 5949 14373 1726327
Ligament sprain 237.25 56.54 55 6026 410 1740290
Low density lipoprotein increased 234.36 56.54 63 6018 906 1739794
Aortic valve sclerosis 231.82 56.54 45 6036 119 1740581
Bundle branch block left 229.71 56.54 60 6021 767 1739933
Haematochezia 229.62 56.54 92 5989 4840 1735860
Sleep disorder 228.76 56.54 87 5994 3976 1736724
Oedema 227.86 56.54 101 5980 6847 1733853
Tendonitis 227.40 56.54 67 6014 1366 1739334
Cardiac valve disease 225.07 56.54 55 6026 526 1740174
Nocturia 223.08 56.54 63 6018 1098 1739602
Carotid bruit 222.73 56.54 38 6043 30 1740670
Lumbar spinal stenosis 221.71 56.54 49 6032 286 1740414
Anxiety disorder 220.46 56.54 47 6034 225 1740475
Haematuria 219.68 56.54 101 5980 7459 1733241
Diverticulum intestinal 217.85 56.54 52 6029 446 1740254
Loss of consciousness 217.34 56.54 125 5956 14750 1725950
Paraesthesia 217.29 56.54 111 5970 10340 1730360
Essential hypertension 214.03 56.54 47 6034 265 1740435
Renal disorder 213.96 56.54 83 5998 4003 1736697
Congestive cardiomyopathy 212.71 56.54 61 6020 1126 1739574
Diarrhoea 212.10 56.54 205 5876 53647 1687053
Hypokalaemia 210.08 56.54 93 5988 6281 1734419
Haematoma 202.53 56.54 79 6002 3866 1736834
Vertigo 200.83 56.54 81 6000 4332 1736368
Neuropathy peripheral 200.25 56.54 101 5980 9152 1731548
Exostosis 200.02 56.54 48 6033 422 1740278
Mitral valve prolapse 199.06 56.54 39 6042 110 1740590
Cervicobrachial syndrome 198.58 56.54 36 6045 55 1740645
Vision blurred 194.24 56.54 96 5985 8327 1732373
Atrioventricular block first degree 189.86 56.54 53 6028 883 1739817
Amnesia 189.43 56.54 80 6001 4811 1735889
Sinus disorder 188.92 56.54 54 6027 984 1739716
Dehydration 185.08 56.54 120 5961 17538 1723162
Rheumatoid arthritis 184.27 56.54 77 6004 4508 1736192
Migraine 184.24 56.54 64 6017 2247 1738453
Pulmonary congestion 183.45 56.54 60 6021 1745 1738955
Ischaemia 183.18 56.54 51 6030 841 1739859
Intervertebral disc disorder 182.95 56.54 42 6039 298 1740402
Glucose tolerance impaired 182.52 56.54 44 6037 395 1740305
Acute kidney injury 182.33 56.54 156 5925 34788 1705912
Spinal disorder 181.89 56.54 46 6035 512 1740188
Vomiting 181.76 56.54 162 5919 38153 1702547
Aneurysm 178.77 56.54 43 6038 382 1740318
Prostatitis 178.58 56.54 51 6030 926 1739774
Inguinal hernia 178.08 56.54 52 6029 1025 1739675
Hemiparesis 177.43 56.54 65 6016 2669 1738031
Tachycardia 176.07 56.54 103 5978 12525 1728175
Mitral valve calcification 173.45 56.54 32 6049 57 1740643
Chronic fatigue syndrome 173.21 56.54 33 6048 76 1740624
Sinus tachycardia 171.01 56.54 62 6019 2470 1738230
Aortic valve stenosis 170.59 56.54 38 6043 231 1740469
Hypothyroidism 170.34 56.54 62 6019 2498 1738202
Cyst 170.32 56.54 46 6035 673 1740027
Supraventricular extrasystoles 170.00 56.54 45 6036 607 1740093
Hypoxia 167.95 56.54 78 6003 5885 1734815
Leukocytosis 164.69 56.54 66 6015 3467 1737233
Anaemia postoperative 164.17 56.54 32 6049 87 1740613
Brain stem infarction 164.02 56.54 38 6043 282 1740418
Emotional disorder 163.37 56.54 49 6032 1063 1739637
Sinus node dysfunction 162.51 56.54 44 6037 650 1740050
Weight decreased 162.04 56.54 122 5959 22631 1718069
Gastritis erosive 161.25 56.54 47 6034 920 1739780
Prostate cancer 160.45 56.54 70 6011 4556 1736144
Hepatic steatosis 158.70 56.54 59 6022 2525 1738175
Dysphagia 157.90 56.54 89 5992 10079 1730621
Flank pain 155.54 56.54 46 6035 949 1739751
High density lipoprotein decreased 155.40 56.54 42 6039 616 1740084
Cerebral ischaemia 155.35 56.54 47 6034 1051 1739649
Lung neoplasm 155.28 56.54 43 6038 694 1740006
Emphysema 153.49 56.54 48 6033 1203 1739497
Drug ineffective 152.80 56.54 187 5894 63614 1677086
Post procedural complication 152.25 56.54 56 6025 2324 1738376
Hypertriglyceridaemia 150.89 56.54 47 6034 1162 1739538
Oesophagitis 150.73 56.54 51 6030 1650 1739050
Anhedonia 150.69 56.54 43 6038 778 1739922
Cerebral artery occlusion 149.65 56.54 33 6048 190 1740510
Myalgia 148.43 56.54 100 5981 15558 1725142
Supraventricular tachycardia 147.91 56.54 50 6031 1613 1739087
Device occlusion 145.76 56.54 43 6038 879 1739821
Cerebellar infarction 145.64 56.54 36 6045 362 1740338
Sciatica 142.99 56.54 41 6040 755 1739945
Onychomycosis 142.98 56.54 34 6047 286 1740414
Diverticulitis 142.45 56.54 53 6028 2272 1738428
Hypersensitivity 142.38 56.54 84 5997 10360 1730340
Atrial flutter 140.31 56.54 50 6031 1892 1738808
Viral infection 138.31 56.54 55 6026 2828 1737872
Heart injury 137.26 56.54 34 6047 345 1740355
Panic disorder 137.00 56.54 32 6049 247 1740453
Peripheral venous disease 136.32 56.54 32 6049 253 1740447
Laryngeal pain 136.25 56.54 38 6043 630 1740070
Post-traumatic stress disorder 133.95 56.54 32 6049 275 1740425
Duodenitis 132.75 56.54 37 6044 612 1740088
Lung disorder 131.91 56.54 63 6018 5056 1735644
Prostatic disorder 131.66 56.54 35 6046 480 1740220
Barrett's oesophagus 131.56 56.54 32 6049 299 1740401
Epicondylitis 130.54 56.54 27 6054 108 1740592
Acute sinusitis 130.34 56.54 29 6052 175 1740525
Glaucoma 129.51 56.54 41 6040 1070 1739630
Hyperglycaemia 128.34 56.54 62 6019 5103 1735597
Hypertensive crisis 128.30 56.54 44 6037 1483 1739217
Ulcer 127.39 56.54 41 6040 1130 1739570
Pyrexia 127.37 56.54 146 5935 46254 1694446
Iron deficiency anaemia 127.15 56.54 41 6040 1137 1739563
Eye disorder 127.13 56.54 44 6037 1525 1739175
Costochondritis 126.68 56.54 25 6056 74 1740626
Musculoskeletal discomfort 124.96 56.54 39 6042 970 1739730
Major depression 124.83 56.54 36 6045 677 1740023
Gastrointestinal disorder 124.06 56.54 59 6022 4689 1736011
Duodenal ulcer 122.19 56.54 44 6037 1716 1738984
Cardiogenic shock 121.85 56.54 48 6033 2406 1738294
Staphylococcal infection 121.49 56.54 58 6023 4649 1736051
Blood pressure inadequately controlled 121.05 56.54 34 6047 579 1740121
Diabetes mellitus inadequate control 120.23 56.54 44 6037 1798 1738902
Polyp 119.36 56.54 32 6049 454 1740246
Upper gastrointestinal haemorrhage 119.20 56.54 50 6031 2949 1737751
Memory impairment 119.00 56.54 64 6017 6599 1734101
Treatment noncompliance 118.95 56.54 59 6022 5142 1735558
Confusional state 118.92 56.54 99 5982 21179 1719521
Sudden cardiac death 118.33 56.54 36 6045 820 1739880
Oesophageal disorder 117.68 56.54 28 6053 236 1740464
Azotaemia 117.50 56.54 35 6046 740 1739960
Embolism 116.98 56.54 38 6043 1079 1739621
Cardiac aneurysm 116.65 56.54 25 6056 123 1740577
Spondylolisthesis 115.24 56.54 24 6057 100 1740600
Prostate examination abnormal 114.47 56.54 22 6059 54 1740646
Seborrhoeic keratosis 114.40 56.54 25 6056 137 1740563
Muscle strain 113.48 56.54 32 6049 553 1740147
Sexual dysfunction 113.28 56.54 42 6039 1781 1738919
Tinnitus 112.87 56.54 49 6032 3146 1737554
Skin ulcer 112.54 56.54 47 6034 2741 1737959
Umbilical hernia 111.74 56.54 30 6051 428 1740272
Haematemesis 110.11 56.54 53 6028 4324 1736376
Cerebral atrophy 109.98 56.54 33 6048 716 1739984
Panic attack 108.99 56.54 41 6040 1811 1738889
Groin pain 108.78 56.54 33 6048 744 1739956
Left ventricular failure 107.81 56.54 32 6049 668 1740032
Ureterolithiasis 107.77 56.54 28 6053 349 1740351
Acne cystic 107.48 56.54 21 6060 58 1740642
Silent myocardial infarction 107.18 56.54 23 6058 114 1740586
Atrioventricular block complete 106.73 56.54 38 6043 1433 1739267
Lung infiltration 106.37 56.54 42 6039 2117 1738583
Dermatitis contact 105.59 56.54 31 6050 622 1740078
Head injury 105.59 56.54 46 6035 2978 1737722
Pericarditis 105.07 56.54 38 6043 1500 1739200
Synovial cyst 104.84 56.54 26 6055 265 1740435
Ventricular arrhythmia 103.03 56.54 31 6050 679 1740021
Renal artery stenosis 102.92 56.54 25 6056 232 1740468
Joint swelling 102.31 56.54 57 6024 6296 1734404
Mental status changes 101.93 56.54 56 6025 6019 1734681
Nervousness 101.65 56.54 41 6040 2186 1738514
Irritable bowel syndrome 101.11 56.54 29 6052 534 1740166
Pollakiuria 100.22 56.54 44 6037 2902 1737798
Diplopia 99.29 56.54 42 6039 2528 1738172
Gastroenteritis 97.30 56.54 39 6042 2045 1738655
Pulmonary valve incompetence 97.07 56.54 22 6059 146 1740554
Rib fracture 96.40 56.54 37 6044 1727 1738973
Occult blood positive 96.31 56.54 28 6053 542 1740158
Deafness 95.99 56.54 38 6043 1928 1738772
Cerumen impaction 95.33 56.54 20 6061 87 1740613
Dressler's syndrome 95.21 56.54 18 6063 39 1740661
Extrasystoles 95.17 56.54 30 6051 771 1739929
Nervous system disorder 94.46 56.54 40 6041 2414 1738286
Trigger finger 94.05 56.54 21 6060 129 1740571
Dermatitis 94.00 56.54 36 6045 1670 1739030
Infection 93.89 56.54 69 6012 12291 1728409
Skin lesion 93.43 56.54 42 6039 2930 1737770
Pharyngitis 92.24 56.54 32 6049 1116 1739584
Epistaxis 90.65 56.54 58 6023 8248 1732452
Helicobacter infection 90.56 56.54 25 6056 398 1740302
Joint dislocation 90.53 56.54 27 6054 573 1740127
Dementia 90.21 56.54 37 6044 2059 1738641
Multi-organ disorder 90.18 56.54 23 6058 265 1740435
Facial paralysis 89.95 56.54 36 6045 1880 1738820
Abdominal hernia 88.45 56.54 24 6057 357 1740343
Labile hypertension 88.01 56.54 16 6065 25 1740675
Heart rate increased 87.69 56.54 52 6029 6458 1734242
Fibromyalgia 87.14 56.54 23 6058 306 1740394
Plantar fasciitis 87.02 56.54 21 6060 189 1740511
Hypoacusis 86.98 56.54 38 6043 2475 1738225
Actinic keratosis 86.95 56.54 26 6055 557 1740143
Urinary retention 85.75 56.54 48 6033 5347 1735353
Gouty arthritis 85.68 56.54 21 6060 203 1740497
Generalised anxiety disorder 85.48 56.54 19 6062 114 1740586
Colon adenoma 85.31 56.54 21 6060 207 1740493
Ischaemic cerebral infarction 85.03 56.54 21 6060 210 1740490
Orthostatic hypotension 84.63 56.54 41 6040 3390 1737310
Cardiometabolic syndrome 84.10 56.54 22 6059 282 1740418
Nephrosclerosis 83.59 56.54 20 6061 173 1740527
Coagulopathy 83.29 56.54 38 6043 2743 1737957
Intracardiac thrombus 82.51 56.54 25 6056 561 1740139
Electrocardiogram ST-T change 81.63 56.54 19 6062 144 1740556
Restless legs syndrome 80.36 56.54 28 6053 989 1739711
Chronic sinusitis 79.93 56.54 20 6061 212 1740488
Lipoma 79.79 56.54 21 6060 276 1740424
Hyperkalaemia 79.45 56.54 54 6027 8493 1732207
Mental disorder 79.37 56.54 37 6044 2806 1737894
Melaena 79.14 56.54 45 6036 5165 1735535
Herpes zoster 79.03 56.54 43 6038 4530 1736170
Vertigo positional 78.34 56.54 18 6063 128 1740572
Flatulence 78.26 56.54 37 6044 2897 1737803
Blindness unilateral 77.89 56.54 27 6054 939 1739761
Haemorrhage 77.17 56.54 56 6025 9773 1730927
Visual acuity reduced 76.89 56.54 40 6041 3848 1736852
Coordination abnormal 76.82 56.54 30 6051 1467 1739233
Ulcer haemorrhage 76.30 56.54 22 6059 413 1740287
Myofascial pain syndrome 76.10 56.54 15 6066 44 1740656
Hypoxic-ischaemic encephalopathy 76.07 56.54 26 6055 866 1739834
Retinal vein occlusion 75.66 56.54 22 6059 426 1740274
Electrocardiogram abnormal 75.54 56.54 28 6053 1185 1739515
Knee arthroplasty 75.06 56.54 26 6055 902 1739798
Basal cell carcinoma 74.58 56.54 34 6047 2449 1738251
Balance disorder 74.57 56.54 45 6036 5767 1734933
Limb discomfort 74.55 56.54 29 6052 1403 1739297
Wound infection 74.25 56.54 26 6055 932 1739768
Hyperhomocysteinaemia 74.16 56.54 14 6067 30 1740670
Dizziness postural 73.36 56.54 25 6056 825 1739875
Rectal polyp 73.31 56.54 16 6065 87 1740613
Dysuria 73.25 56.54 38 6043 3634 1737066
Nasal congestion 73.20 56.54 36 6045 3075 1737625
Pericardial effusion 73.18 56.54 37 6044 3353 1737347
Rash 72.81 56.54 101 5980 38592 1702108
Functional gastrointestinal disorder 72.17 56.54 20 6061 323 1740377
Alcoholism 71.88 56.54 22 6059 511 1740189
QRS axis abnormal 71.66 56.54 18 6063 194 1740506
Otitis media 71.58 56.54 21 6060 420 1740280
Ligament injury 71.17 56.54 15 6066 67 1740633
Sacroiliitis 71.15 56.54 17 6064 146 1740554
Disturbance in attention 70.91 56.54 39 6042 4195 1736505
Haemorrhagic stroke 70.87 56.54 27 6054 1234 1739466
Vascular pseudoaneurysm 70.62 56.54 20 6061 351 1740349
Embolic stroke 70.51 56.54 24 6057 789 1739911
Sepsis 70.41 56.54 71 6010 19367 1721333
Eczema 70.36 56.54 32 6049 2292 1738408
Foot deformity 70.21 56.54 21 6060 450 1740250
Joint effusion 69.57 56.54 22 6059 571 1740129
Mitral valve disease 69.52 56.54 18 6063 221 1740479
Retinal artery occlusion 69.43 56.54 20 6061 374 1740326
Dermal cyst 69.37 56.54 18 6063 223 1740477
Visual impairment 69.26 56.54 44 6037 6174 1734526
Acute respiratory failure 69.11 56.54 34 6047 2906 1737794
Sudden death 69.11 56.54 34 6047 2906 1737794
Ingrowing nail 69.10 56.54 17 6064 167 1740533
Wheezing 68.85 56.54 38 6043 4115 1736585
Atrioventricular block 68.67 56.54 27 6054 1344 1739356
Hypokinesia 68.39 56.54 26 6055 1181 1739519
Acute pulmonary oedema 68.18 56.54 26 6055 1191 1739509
Labyrinthitis 67.01 56.54 16 6065 137 1740563
Gait disturbance 66.65 56.54 57 6024 12613 1728087
Bacterial infection 66.59 56.54 29 6052 1873 1738827
Dyspnoea paroxysmal nocturnal 66.50 56.54 16 6065 142 1740558
Blood pressure systolic increased 66.30 56.54 28 6053 1677 1739023
Lower gastrointestinal haemorrhage 65.83 56.54 25 6056 1132 1739568
Vertebral artery occlusion 65.73 56.54 13 6068 39 1740661
Sinus arrhythmia 65.41 56.54 17 6064 212 1740488
Abdominal distension 65.37 56.54 43 6038 6401 1734299
Cholecystitis chronic 65.05 56.54 16 6065 157 1740543
Dementia Alzheimer's type 64.83 56.54 21 6060 590 1740110
Fear 64.72 56.54 26 6055 1370 1739330
Swelling 64.53 56.54 44 6037 6952 1733748
Hepatic enzyme increased 64.31 56.54 43 6038 6578 1734122
Lipids increased 63.93 56.54 17 6064 233 1740467
Electrocardiogram ST segment elevation 63.45 56.54 23 6058 913 1739787
Hyponatraemia 63.29 56.54 48 6033 8952 1731748
Osteopenia 62.81 56.54 20 6061 531 1740169
Normochromic normocytic anaemia 62.75 56.54 21 6060 655 1740045
Patellofemoral pain syndrome 62.56 56.54 12 6069 29 1740671
Liver function test abnormal 62.48 56.54 40 6041 5686 1735014
Haemorrhoidal haemorrhage 62.36 56.54 20 6061 544 1740156
Tobacco abuse 62.06 56.54 13 6068 56 1740644
Blindness 61.76 56.54 31 6050 2765 1737935
Hypertensive cardiomyopathy 61.51 56.54 13 6068 59 1740641
Blood potassium decreased 61.38 56.54 29 6052 2266 1738434
Peripheral artery stenosis 61.28 56.54 15 6066 144 1740556
Cervical spinal stenosis 60.55 56.54 15 6066 152 1740548
Pneumonia aspiration 60.48 56.54 38 6043 5228 1735472
Orthopnoea 60.31 56.54 20 6061 606 1740094
Adjustment disorder 60.04 56.54 14 6067 107 1740593
Pneumothorax 59.70 56.54 30 6051 2682 1738018
Melanocytic naevus 59.02 56.54 18 6063 413 1740287
Intracranial aneurysm 58.90 56.54 16 6065 239 1740461
Visual field defect 58.72 56.54 23 6058 1133 1739567
Hypercoagulation 58.53 56.54 16 6065 245 1740455
Vascular graft occlusion 58.48 56.54 13 6068 78 1740622
Essential tremor 58.34 56.54 13 6068 79 1740621
Deafness neurosensory 58.28 56.54 19 6062 545 1740155
Sinus congestion 58.16 56.54 21 6060 824 1739876
Incontinence 57.77 56.54 22 6059 1004 1739696
Abdominal pain lower 57.76 56.54 23 6058 1184 1739516
Incision site complication 57.65 56.54 13 6068 84 1740616
Left ventricular end-diastolic pressure increased 57.52 56.54 11 6070 26 1740674
Hypovolaemia 57.16 56.54 23 6058 1217 1739483
Hypoglycaemia 57.12 56.54 44 6037 8394 1732306
Skin abrasion 57.03 56.54 21 6060 872 1739828
Encephalomalacia 56.87 56.54 13 6068 90 1740610
Thrombocytopenia 56.59 56.54 66 6015 21183 1719517

Pharmacologic Action:

SourceCodeDescription
ATC M01AH02 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Coxibs
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35480 analgesic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D052246 Cyclooxygenase 2 Inhibitors
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Migraine indication 37796009 DOID:6364
Rheumatoid arthritis indication 69896004 DOID:7148
Dysmenorrhea indication 266599000
Osteoarthritis indication 396275006
Juvenile rheumatoid arthritis indication 410795001

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 6.51 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 5.77 CHEMBL
Prostaglandin E2 receptor EP2 subtype GPCR Ki 7.47 PDSP
Prostaglandin G/H synthase 1 Enzyme IC50 4.63 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 6.52 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 7.92 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 6.12 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.94 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 6.37 CHEMBL

External reference:

IDSource
4021160 VUID
N0000148611 NUI
C0762662 UMLSCUI
D00568 KEGG_DRUG
0QTW8Z7MCR UNII
7768 INN_ID
116095002 SNOMEDCT_US
d04433 MMSL
8220 MMSL
232158 RXNORM
387008005 SNOMEDCT_US
4021160 VANDF
007787 NDDF
CHEMBL122 ChEMBL_ID
DB00533 DRUGBANK_ID
RCX PDB_CHEM_ID
CHEBI:8887 CHEBI
5090 PUBCHEM_CID
2893 IUPHAR_LIGAND_ID
C116926 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None