rofecoxib Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
selective cyclo-oxygenase inhibitors 2397 162011-90-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • rofecoxib
  • vioxx
  • ceeoxx
a sulfonylphenyl furanone; withdrawn out of concern for TOXICITY
  • Molecular weight: 314.36
  • Formula: C17H14O4S
  • CLOGP: 1.80
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 60.44
  • ALOGS: -4.47
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
25 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.65 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 93 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.13 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
May 20, 1999 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebrovascular accident 2691.86 13.35 1904 85844 99135 46499179
Myocardial infarction 2574.91 13.35 1828 85920 95700 46502614
Coronary artery disease 2523.62 13.35 1242 86506 32510 46565804
Hypertension 1111.36 13.35 1591 86157 194765 46403549
Hyperlipidaemia 962.56 13.35 535 87213 18004 46580310
Transient ischaemic attack 926.70 13.35 658 87090 34245 46564069
Chest pain 906.21 13.35 1366 86382 174958 46423356
Angina pectoris 814.64 13.35 549 87199 26226 46572088
Acute myocardial infarction 723.26 13.35 547 87201 31377 46566937
Angina unstable 720.05 13.35 329 87419 7219 46591095
Cardiovascular disorder 691.34 13.35 373 87375 11814 46586500
Off label use 655.72 13.35 12 87736 379829 46218485
Mitral valve incompetence 642.42 13.35 415 87333 18437 46579877
Ventricular hypertrophy 606.59 13.35 239 87509 3575 46594739
Depression 594.90 13.35 1110 86638 168994 46429320
Cardiac failure congestive 574.77 13.35 782 86966 90968 46507346
Gastrooesophageal reflux disease 521.60 13.35 670 87078 73674 46524640
Carotid artery stenosis 490.92 13.35 224 87524 4896 46593418
Arteriosclerosis 480.86 13.35 272 87476 9461 46588853
Arteriosclerosis coronary artery 463.57 13.35 250 87498 7906 46590408
Drug ineffective 450.00 13.35 371 87377 677467 45920847
Coronary artery stenosis 429.34 13.35 199 87549 4514 46593800
Lacunar infarction 383.77 13.35 168 87580 3317 46594997
Tricuspid valve incompetence 380.91 13.35 266 87482 13451 46584863
Cardiac disorder 371.71 13.35 435 87313 43423 46554891
Emotional distress 326.48 13.35 343 87405 30364 46567950
Hypercholesterolaemia 325.78 13.35 226 87522 11304 46587010
Blood cholesterol increased 319.47 13.35 385 87363 39628 46558686
Coronary artery occlusion 317.64 13.35 195 87553 7907 46590407
Myocardial ischaemia 298.63 13.35 223 87525 12526 46585788
Osteoarthritis 296.98 13.35 466 87282 61559 46536755
Peripheral vascular disorder 295.11 13.35 167 87581 5810 46592504
Ventricular dysfunction 287.64 13.35 129 87619 2703 46595611
Product dose omission issue 279.85 13.35 8 87740 168512 46429802
Cardiomegaly 276.32 13.35 243 87505 17239 46581075
Chronic obstructive pulmonary disease 263.49 13.35 424 87324 57209 46541105
Diarrhoea 259.81 13.35 408 87340 559194 46039120
Malaise 254.70 13.35 154 87594 331078 46267236
Completed suicide 238.39 13.35 8 87740 145912 46452402
Hypertensive heart disease 235.26 13.35 109 87639 2469 46595845
Injury 226.43 13.35 342 87406 43685 46554629
Death 223.64 13.35 182 87566 335366 46262948
Peripheral swelling 223.57 13.35 20 87728 158051 46440263
Aortic valve incompetence 222.14 13.35 139 87609 5831 46592483
Dilatation atrial 221.45 13.35 99 87649 2058 46596256
Cerebral infarction 213.44 13.35 241 87507 23125 46575189
Rash 210.72 13.35 216 87532 356296 46242018
Gastritis 208.82 13.35 289 87459 34089 46564225
Anxiety 206.20 13.35 780 86968 181177 46417137
Diverticulum 199.96 13.35 167 87581 11039 46587275
Nausea 197.89 13.35 650 87098 686804 45911510
Neutropenia 194.94 13.35 21 87727 143183 46455131
Toxicity to various agents 193.48 13.35 78 87670 211688 46386626
Pyrexia 192.10 13.35 224 87524 348578 46249736
Condition aggravated 190.91 13.35 112 87636 244940 46353374
Pruritus 185.66 13.35 113 87635 242239 46356075
Ischaemic cardiomyopathy 185.58 13.35 93 87655 2517 46595797
Fatigue 184.53 13.35 562 87186 608135 45990179
Non-cardiac chest pain 183.18 13.35 124 87624 5954 46592360
Hiatus hernia 181.35 13.35 197 87551 18105 46580209
Peptic ulcer 175.17 13.35 103 87645 3855 46594459
Thrombosis 172.24 13.35 347 87401 55722 46542592
Intervertebral disc degeneration 170.11 13.35 164 87584 13088 46585226
Carpal tunnel syndrome 170.02 13.35 178 87570 15681 46582633
Infusion related reaction 160.30 13.35 7 87741 101201 46497113
White blood cell count decreased 159.19 13.35 14 87734 112217 46486097
Carotid artery disease 155.46 13.35 72 87676 1629 46596685
Exposure during pregnancy 152.13 13.35 14 87734 108198 46490116
Injection site pain 150.27 13.35 14 87734 107138 46491176
Cerebrovascular disorder 148.66 13.35 83 87665 2811 46595503
Febrile neutropenia 148.38 13.35 7 87741 94620 46503694
Dyslipidaemia 148.11 13.35 105 87643 5435 46592879
Rotator cuff syndrome 148.02 13.35 143 87605 11440 46586874
Haemorrhoids 145.44 13.35 178 87570 18599 46579715
Vomiting 141.27 13.35 412 87336 452382 46145932
Organ failure 139.98 13.35 76 87672 2434 46595880
Alopecia 138.51 13.35 66 87682 162348 46435966
Cardiac murmur 136.79 13.35 136 87612 11268 46587046
Drug interaction 132.80 13.35 112 87636 202982 46395332
Spinal osteoarthritis 132.71 13.35 148 87600 14003 46584311
Rhinitis allergic 125.42 13.35 104 87644 6804 46591510
Ischaemic stroke 123.85 13.35 155 87593 16567 46581747
Ventricular extrasystoles 123.67 13.35 127 87621 10936 46587378
Stress urinary incontinence 123.40 13.35 66 87682 2050 46596264
Multiple injuries 122.14 13.35 64 87684 1905 46596409
Type 2 diabetes mellitus 122.04 13.35 168 87580 19707 46578607
Adverse event 120.14 13.35 224 87524 33960 46564354
Coronary artery restenosis 119.97 13.35 41 87707 398 46597916
Sleep apnoea syndrome 117.71 13.35 175 87573 22026 46576288
Platelet count decreased 116.83 13.35 23 87725 100001 46498313
Cervicobrachial syndrome 116.15 13.35 49 87699 880 46597434
Acute coronary syndrome 115.63 13.35 118 87630 10086 46588228
Carotid artery occlusion 114.54 13.35 68 87680 2591 46595723
Oropharyngeal pain 111.56 13.35 7 87741 74161 46524153
Erythema 111.49 13.35 65 87683 142755 46455559
Pain 110.20 13.35 492 87256 476456 46121858
Cardiac valve disease 109.96 13.35 77 87671 3907 46594407
Carotid bruit 108.87 13.35 44 87704 705 46597609
Disease progression 106.62 13.35 21 87727 91279 46507035
Somnolence 106.42 13.35 83 87665 156438 46441876
Laryngeal pain 106.15 13.35 80 87668 4554 46593760
Rheumatoid arthritis 105.47 13.35 181 87567 240034 46358280
Hypothyroidism 104.73 13.35 201 87547 31137 46567177
Musculoskeletal chest pain 103.66 13.35 148 87600 17958 46580356
Treatment failure 103.41 13.35 24 87724 93063 46505251
Blood triglycerides increased 103.29 13.35 119 87629 11664 46586650
Diabetes mellitus 102.61 13.35 264 87484 49801 46548513
Oedema peripheral 101.33 13.35 578 87170 159128 46439186
Injection site erythema 101.01 13.35 11 87737 74416 46523898
Drug abuse 98.40 13.35 5 87743 63403 46534911
Intermittent claudication 95.68 13.35 53 87695 1767 46596547
Aortic arteriosclerosis 95.37 13.35 82 87666 5639 46592675
Contraindicated product administered 94.17 13.35 18 87730 79929 46518385
Chronic fatigue syndrome 93.74 13.35 44 87704 1027 46597287
Road traffic accident 93.12 13.35 163 87585 23528 46574786
Thrombocytopenia 92.71 13.35 62 87686 126519 46471795
Anxiety disorder 92.60 13.35 66 87682 3445 46594869
Inappropriate schedule of product administration 92.46 13.35 8 87740 65005 46533309
Pancytopenia 92.38 13.35 23 87725 85035 46513279
Dementia Alzheimer's type 92.14 13.35 45 87703 1150 46597164
Arrhythmia 91.13 13.35 202 87546 34639 46563675
Cerebral ischaemia 90.21 13.35 83 87665 6242 46592072
Meniscus injury 88.09 13.35 80 87668 5916 46592398
Hospitalisation 86.96 13.35 9 87739 63376 46534938
Decreased appetite 86.94 13.35 144 87604 193692 46404622
Panic disorder 86.25 13.35 56 87692 2505 46595809
Large intestine polyp 85.62 13.35 89 87659 7772 46590542
Angiopathy 85.45 13.35 68 87680 4195 46594119
Intentional overdose 84.66 13.35 11 87737 64933 46533381
Joint swelling 84.55 13.35 113 87635 165960 46432354
Deep vein thrombosis 83.64 13.35 334 87414 79439 46518875
Intervertebral disc protrusion 82.30 13.35 142 87606 20263 46578051
Malignant neoplasm progression 82.27 13.35 12 87736 64914 46533400
Infection 82.07 13.35 78 87670 133514 46464800
Back injury 82.01 13.35 82 87666 6839 46591475
Mitral valve prolapse 81.91 13.35 52 87696 2237 46596077
Neck injury 79.89 13.35 46 87702 1654 46596660
Diastolic dysfunction 78.52 13.35 71 87677 5221 46593093
Bronchitis 78.30 13.35 400 87348 105579 46492735
Cerebral artery occlusion 76.80 13.35 37 87711 917 46597397
General physical health deterioration 76.64 13.35 63 87685 115706 46482608
Radiculopathy 76.17 13.35 68 87680 4917 46593397
Sinus bradycardia 75.01 13.35 110 87638 13672 46584642
Heart rate irregular 74.48 13.35 129 87619 18462 46579852
Bundle branch block left 74.32 13.35 75 87673 6324 46591990
Leukopenia 73.21 13.35 19 87729 68324 46529990
Obesity 72.48 13.35 110 87638 14096 46584218
Pulmonary embolism 72.13 13.35 398 87350 108187 46490127
Back disorder 71.33 13.35 87 87661 9054 46589260
Therapeutic product effect incomplete 70.92 13.35 29 87719 78124 46520190
Costochondritis 70.88 13.35 46 87702 2056 46596258
Arthropathy 69.19 13.35 329 87419 84371 46513943
Wrong technique in product usage process 69.08 13.35 10 87738 54412 46543902
Injection site reaction 67.73 13.35 6 87742 47843 46550471
Uterine disorder 67.39 13.35 49 87699 2639 46595675
Psoriasis 66.87 13.35 32 87716 78572 46519742
Lumbar radiculopathy 66.84 13.35 42 87706 1774 46596540
Spinal stenosis 66.67 13.35 99 87649 12444 46585870
Palpitations 66.53 13.35 354 87394 94905 46503409
Ligament sprain 66.20 13.35 90 87658 10429 46587885
Abortion spontaneous 65.99 13.35 4 87744 43642 46554672
Oxygen saturation decreased 65.51 13.35 24 87724 69140 46529174
Prescribed overdose 65.16 13.35 89 87659 10360 46587954
Cardiomyopathy 65.01 13.35 112 87636 15961 46582353
Renal artery stenosis 64.93 13.35 41 87707 1747 46596567
Acute kidney injury 64.64 13.35 227 87521 235628 46362686
Intentional product misuse 63.85 13.35 7 87741 47121 46551193
Incorrect dose administered 63.70 13.35 6 87742 45544 46552770
Drug intolerance 63.37 13.35 112 87636 146937 46451377
C-reactive protein increased 63.31 13.35 16 87732 58574 46539740
Essential hypertension 62.33 13.35 57 87691 4253 46594061
Cerebral atrophy 61.72 13.35 59 87689 4657 46593657
Cerebral artery stenosis 61.13 13.35 24 87724 355 46597959
Muscular weakness 60.76 13.35 50 87698 91794 46506520
Flushing 60.23 13.35 23 87725 64591 46533723
Chills 60.23 13.35 55 87693 95977 46502337
Aneurysm 60.22 13.35 45 87703 2528 46595786
Urticaria 60.20 13.35 80 87668 117812 46480502
Atrial fibrillation 59.88 13.35 366 87382 103224 46495090
Lower respiratory tract infection 59.61 13.35 15 87733 55074 46543240
Cerebral arteriosclerosis 59.46 13.35 22 87726 274 46598040
Brain stem infarction 59.42 13.35 30 87718 825 46597489
Glossodynia 59.09 13.35 7 87741 44366 46553948
Irritable bowel syndrome 58.99 13.35 109 87639 16406 46581908
Acute sinusitis 58.65 13.35 53 87695 3894 46594420
Septic shock 58.47 13.35 18 87730 57875 46540439
Cystocele 58.24 13.35 33 87715 1150 46597164
Neck pain 57.50 13.35 231 87517 55075 46543239
Blood pressure inadequately controlled 57.43 13.35 55 87693 4351 46593963
Electrocardiogram ST-T change 57.41 13.35 32 87716 1080 46597234
Injection site swelling 57.23 13.35 5 87743 40322 46557992
Tendonitis 57.10 13.35 99 87649 14178 46584136
Arterial occlusive disease 57.07 13.35 57 87691 4747 46593567
Mitral valve calcification 56.89 13.35 31 87717 1000 46597314
Plasma cell myeloma 56.86 13.35 8 87740 44470 46553844
Coronary artery thrombosis 56.02 13.35 32 87716 1133 46597181
Gallbladder disorder 55.73 13.35 110 87638 17388 46580926
Renal cyst 55.21 13.35 75 87673 8684 46589630
Generalised anxiety disorder 55.17 13.35 36 87712 1624 46596690
Hypersensitivity 54.93 13.35 126 87622 150195 46448119
Stomatitis 54.81 13.35 30 87718 68267 46530047
Intervertebral disc disorder 54.76 13.35 52 87696 4070 46594244
Bursitis 54.10 13.35 117 87631 19725 46578589
Pulmonary valve incompetence 54.02 13.35 33 87715 1325 46596989
Cerebellar infarction 53.94 13.35 37 87711 1815 46596499
Occult blood positive 53.17 13.35 48 87700 3522 46594792
Dyspepsia 53.05 13.35 262 87486 68210 46530104
Sepsis 53.00 13.35 110 87638 135904 46462410
Supraventricular extrasystoles 52.79 13.35 51 87697 4078 46594236
Hand deformity 52.78 13.35 3 87745 34571 46563743
Mobility decreased 52.56 13.35 24 87724 60570 46537744
Lumbar spinal stenosis 51.94 13.35 52 87696 4343 46593971
Ventricular hypokinesia 51.45 13.35 50 87698 4028 46594286
Silent myocardial infarction 51.11 13.35 22 87726 416 46597898
Unevaluable event 51.08 13.35 12 87736 46163 46552151
Accelerated hypertension 49.99 13.35 21 87727 373 46597941
Mucosal inflammation 49.85 13.35 7 87741 38969 46559345
Nasopharyngitis 49.36 13.35 138 87610 153860 46444454
Hepatic enzyme increased 48.76 13.35 49 87699 81738 46516576
Joint injury 48.68 13.35 110 87638 19099 46579215
Lung neoplasm 48.68 13.35 57 87691 5683 46592631
Vertigo positional 48.59 13.35 40 87708 2590 46595724
Renal impairment 48.55 13.35 41 87707 74331 46523983
Osteoporosis 48.27 13.35 177 87571 40431 46557883
Ischaemia 48.02 13.35 50 87698 4374 46593940
Stress 47.86 13.35 208 87540 51343 46546971
Fibromyalgia 47.68 13.35 164 87584 36299 46562015
Renal failure 47.64 13.35 371 87377 113223 46485091
Alanine aminotransferase increased 47.24 13.35 58 87690 88393 46509921
Vertebral artery stenosis 46.48 13.35 13 87735 59 46598255
Suicide attempt 45.90 13.35 23 87725 55013 46543301
Weight decreased 45.83 13.35 222 87526 210627 46387687
Aortic valve sclerosis 45.80 13.35 27 87721 1015 46597299
Sinus node dysfunction 45.71 13.35 48 87700 4241 46594073
Major depression 44.79 13.35 59 87689 6631 46591683
Diverticulum intestinal 44.73 13.35 56 87692 5985 46592329
Aortic valve stenosis 44.56 13.35 41 87707 3083 46595231
Patellofemoral pain syndrome 44.24 13.35 21 87727 503 46597811
Rhabdomyolysis 44.22 13.35 12 87736 41897 46556417
Electrocardiogram QT prolonged 43.48 13.35 21 87727 51304 46547010
Plantar fasciitis 43.25 13.35 38 87710 2690 46595624
Breast disorder 43.18 13.35 33 87715 1918 46596396
Bundle branch block right 42.79 13.35 49 87699 4770 46593544
Influenza 42.16 13.35 64 87684 89206 46509108
Iliac artery stenosis 42.16 13.35 11 87737 36 46598278
Low density lipoprotein increased 41.86 13.35 54 87694 5946 46592368
Bone marrow failure 41.24 13.35 4 87744 29665 46568649
Coronary artery insufficiency 41.04 13.35 13 87735 97 46598217
Synovitis 40.69 13.35 33 87715 61042 46537272
Chondromalacia 40.41 13.35 17 87731 303 46598011
Intracardiac thrombus 40.35 13.35 34 87714 2274 46596040
Haemoglobin decreased 40.25 13.35 117 87631 128832 46469482
Musculoskeletal stiffness 40.09 13.35 77 87671 97916 46500398
Hepatic function abnormal 39.99 13.35 8 87740 34413 46563901
No adverse event 39.68 13.35 8 87740 34223 46564091
Labyrinthitis 39.34 13.35 32 87716 2037 46596277
Aortic aneurysm 39.33 13.35 40 87708 3404 46594910
Labile hypertension 38.78 13.35 19 87729 489 46597825
Dysgeusia 38.42 13.35 14 87734 40477 46557837
Multiple organ dysfunction syndrome 38.28 13.35 25 87723 51685 46546629
Foetal exposure during pregnancy 38.22 13.35 6 87742 30741 46567573
Hypotension 38.19 13.35 268 87480 232321 46365993
Rhinorrhoea 38.15 13.35 21 87727 47644 46550670
Loss of personal independence in daily activities 37.97 13.35 31 87717 57152 46541162
Therapeutic response decreased 37.56 13.35 17 87731 43128 46555186
Cataract 37.49 13.35 177 87571 45238 46553076
Nocturia 37.48 13.35 56 87692 7076 46591238
Cholelithiasis 37.39 13.35 158 87590 38523 46559791
Pulmonary arterial hypertension 37.38 13.35 3 87745 25925 46572389
Duodenitis 37.25 13.35 38 87710 3245 46595069
Dilatation ventricular 37.22 13.35 34 87714 2533 46595781
Pregnancy 36.84 13.35 4 87744 27133 46571181
Barrett's oesophagus 36.34 13.35 20 87728 658 46597656
Ventricular tachycardia 36.33 13.35 91 87657 16876 46581438
Oesophageal spasm 36.22 13.35 30 87718 1959 46596355
Anaemia postoperative 35.88 13.35 31 87717 2145 46596169
Otitis media 35.78 13.35 42 87706 4198 46594116
Skin exfoliation 35.57 13.35 9 87739 32929 46565385
Gastric ulcer 35.56 13.35 106 87642 21757 46576557
Iron deficiency anaemia 35.51 13.35 91 87657 17115 46581199
Atelectasis 35.34 13.35 96 87652 18694 46579620
Rectal polyp 35.32 13.35 21 87727 802 46597512
Swelling 35.30 13.35 118 87630 124393 46473921
Red blood cell count decreased 35.06 13.35 9 87739 32614 46565700
Azotaemia 34.91 13.35 42 87706 4309 46594005
Presyncope 34.79 13.35 3 87745 24451 46573863
Abdominal discomfort 34.69 13.35 156 87592 151009 46447305
Therapeutic product effect decreased 34.58 13.35 64 87684 82537 46515777
Diabetic neuropathy 34.44 13.35 39 87709 3750 46594564
Unresponsive to stimuli 34.34 13.35 9 87739 32165 46566149
Goitre 34.14 13.35 46 87702 5285 46593029
Post-traumatic stress disorder 34 13.35 40 87708 4008 46594306
Back pain 33.96 13.35 569 87179 209470 46388844
Syncope 33.81 13.35 323 87425 104480 46493834
Spondylolisthesis 33.79 13.35 35 87713 3043 46595271
Feeling abnormal 33.78 13.35 121 87627 124939 46473375
Supraventricular tachycardia 33.64 13.35 76 87672 13194 46585120
Bladder disorder 33.57 13.35 53 87695 7025 46591289
Vertigo 33.34 13.35 189 87559 51859 46546455
Peripheral venous disease 33.34 13.35 40 87708 4092 46594222
Rash pruritic 33.24 13.35 21 87727 44194 46554120
Fibrocystic breast disease 32.79 13.35 23 87725 1170 46597144
Malignant hypertension 32.66 13.35 22 87726 1047 46597267
Influenza like illness 32.62 13.35 36 87712 57534 46540780
Hemiparesis 32.36 13.35 97 87651 19972 46578342
Hypoxic-ischaemic encephalopathy 32.16 13.35 39 87709 4034 46594280
Gout 32.15 13.35 68 87680 11288 46587026
Blood pressure decreased 32.10 13.35 36 87712 57123 46541191
Aspartate aminotransferase increased 32.05 13.35 62 87686 78638 46519676
Sudden cardiac death 31.68 13.35 29 87719 2166 46596148
Cerebral thrombosis 31.67 13.35 26 87722 1677 46596637
Vascular dementia 31.55 13.35 17 87731 536 46597778
Rectocele 31.32 13.35 20 87728 869 46597445
Transaminases increased 31.13 13.35 7 87741 27754 46570560
Raynaud's phenomenon 31.01 13.35 23 87725 1277 46597037
Uterine leiomyoma 30.88 13.35 55 87693 8044 46590270
Hepatotoxicity 30.81 13.35 5 87743 25004 46573310
Adverse drug reaction 30.78 13.35 23 87725 44339 46553975
Pneumonia 30.73 13.35 510 87238 375810 46222504
Migraine without aura 30.41 13.35 12 87736 180 46598134
Cardiac aneurysm 30.35 13.35 19 87729 797 46597517
Vertebrobasilar insufficiency 30.13 13.35 10 87738 88 46598226
Dry skin 30.12 13.35 20 87728 40996 46557318
Oesophagitis 30.05 13.35 74 87674 13577 46584737
Tinnitus 29.89 13.35 117 87631 27556 46570758
Dementia 29.82 13.35 78 87670 14852 46583462
Gastric disorder 29.73 13.35 114 87634 26591 46571723
Upper respiratory tract infection 29.69 13.35 213 87535 63343 46534971
Gastritis erosive 29.67 13.35 43 87705 5287 46593027
Ischaemic cerebral infarction 29.64 13.35 22 87726 1223 46597091
Lymphocyte count decreased 29.62 13.35 6 87742 25583 46572731
Carotid arteriosclerosis 29.54 13.35 20 87728 960 46597354
Dyspnoea paroxysmal nocturnal 29.44 13.35 19 87729 841 46597473
Clostridium colitis 29.40 13.35 26 87722 1856 46596458
Confusional state 29.38 13.35 178 87570 159714 46438600
Psoriatic arthropathy 29.15 13.35 16 87732 36363 46561951
Urge incontinence 29.10 13.35 18 87730 739 46597575
Myofascial pain syndrome 28.94 13.35 26 87722 1895 46596419
Blood bilirubin increased 28.93 13.35 14 87734 34170 46564144
Leriche syndrome 28.65 13.35 7 87741 16 46598298
Platelet aggregation increased 28.65 13.35 7 87741 16 46598298
Systemic lupus erythematosus 28.64 13.35 49 87699 65131 46533183
Oesophageal disorder 28.55 13.35 27 87721 2102 46596212
Retinal vein occlusion 28.55 13.35 26 87722 1929 46596385
Intervertebral disc displacement 28.25 13.35 15 87733 459 46597855
Interstitial lung disease 28.14 13.35 36 87712 53913 46544401
Multi-organ disorder 28.14 13.35 21 87727 1177 46597137
Urinary tract infection 28.04 13.35 575 87173 219691 46378623
Inner ear disorder 27.95 13.35 15 87733 469 46597845
Hypertensive cardiomyopathy 27.92 13.35 12 87736 226 46598088
Cholestasis 27.81 13.35 8 87740 26885 46571429
Helicobacter test positive 27.79 13.35 14 87734 383 46597931
Rash maculo-papular 27.55 13.35 9 87739 27865 46570449
Heart injury 27.51 13.35 21 87727 1218 46597096
Subclavian artery stenosis 27.29 13.35 10 87738 121 46598193
Feeling hot 27.18 13.35 19 87729 37909 46560405
Gait disturbance 27.06 13.35 161 87587 145102 46453212
Migraine 26.78 13.35 224 87524 69802 46528512
Ascites 26.65 13.35 18 87730 36566 46561748
Scoliosis 26.07 13.35 44 87704 6166 46592148
Hemianopia homonymous 26.00 13.35 16 87732 651 46597663
Intracranial aneurysm 25.93 13.35 31 87717 3159 46595155
Reversible ischaemic neurological deficit 25.74 13.35 7 87741 28 46598286
Seborrhoeic keratosis 25.49 13.35 24 87724 1858 46596456
Serotonin syndrome 25.43 13.35 7 87741 24213 46574101
Pulmonary hypertension 25.26 13.35 134 87614 35859 46562455
Anaphylactic shock 25.10 13.35 4 87744 20270 46578044
Renal disorder 25.01 13.35 108 87640 26578 46571736
Meniere's disease 24.99 13.35 11 87737 220 46598094
Ventricular fibrillation 24.97 13.35 62 87686 11434 46586880
Eustachian tube dysfunction 24.59 13.35 13 87735 394 46597920
Sinus tachycardia 24.58 13.35 93 87655 21556 46576758
Acne 24.50 13.35 4 87744 19915 46578399
Accidental exposure to product 24.28 13.35 5 87743 21076 46577238
Throat irritation 24.21 13.35 12 87736 28889 46569425
Muscle strain 24.20 13.35 45 87703 6804 46591510
Nasal congestion 24.18 13.35 33 87715 48080 46550234
Burning sensation 23.83 13.35 29 87719 44382 46553932
Oesophageal stenosis 23.68 13.35 28 87720 2821 46595493
Amaurosis fugax 23.67 13.35 13 87735 426 46597888
Rash erythematous 23.58 13.35 18 87730 34332 46563982
Electrocardiogram T wave inversion 23.53 13.35 31 87717 3485 46594829
Discomfort 23.47 13.35 32 87716 46638 46551676
Eosinophilia 23.32 13.35 4 87744 19213 46579101
Umbilical hernia 23.02 13.35 27 87721 2697 46595617
Electrocardiogram T wave abnormal 22.79 13.35 25 87723 2321 46595993
Arterial restenosis 22.69 13.35 6 87742 21 46598293
Ill-defined disorder 22.68 13.35 11 87737 26816 46571498
Spinal disorder 22.66 13.35 48 87700 7976 46590338
Dyspnoea exertional 22.60 13.35 167 87581 50122 46548192
Blindness unilateral 22.54 13.35 38 87710 5319 46592995
Electrocardiogram Q waves 22.47 13.35 6 87742 22 46598292
Nephrosclerosis 22.41 13.35 17 87731 977 46597337
Cerumen impaction 22.14 13.35 18 87730 1145 46597169
Embolic cerebral infarction 22.09 13.35 13 87735 487 46597827
Blister 22.04 13.35 31 87717 44600 46553714
Ocular hyperaemia 22.04 13.35 5 87743 19705 46578609
Wound 21.87 13.35 29 87719 42773 46555541
Swollen tongue 21.81 13.35 14 87734 29218 46569096
Bone pain 21.76 13.35 34 87714 46856 46551458
Tension headache 21.76 13.35 26 87722 2648 46595666
Lipoma 21.74 13.35 23 87725 2049 46596265
Parkinson's disease 21.57 13.35 20 87728 1519 46596795
Oral herpes 21.52 13.35 5 87743 19385 46578929
Peripheral artery aneurysm 21.49 13.35 6 87742 27 46598287
Premature baby 21.48 13.35 4 87744 18108 46580206
Swelling face 21.43 13.35 42 87706 53017 46545297
Gastrointestinal haemorrhage 21.36 13.35 231 87517 77142 46521172
Duodenal ulcer 21.34 13.35 44 87704 7174 46591140
Accident at work 21.24 13.35 12 87736 416 46597898
Oral pain 21.22 13.35 10 87738 24787 46573527
Epilepsy 21.22 13.35 9 87739 23729 46574585
Volume blood increased 21.12 13.35 4 87744 0 46598314
Large cell lung cancer 21.12 13.35 4 87744 0 46598314
Epidermal naevus 21.12 13.35 4 87744 0 46598314
Lethargy 21.10 13.35 40 87708 51131 46547183
Thalamic infarction 21.06 13.35 13 87735 532 46597782
Emphysema 20.91 13.35 50 87698 9004 46589310
Dry mouth 20.89 13.35 45 87703 54881 46543433
Breast mass 20.85 13.35 40 87708 6191 46592123
Congestive cardiomyopathy 20.77 13.35 38 87710 5675 46592639
Varicose vein 20.73 13.35 33 87715 4405 46593909
Phlebitis superficial 20.70 13.35 11 87737 337 46597977
Toxic epidermal necrolysis 20.64 13.35 8 87740 22270 46576044
Lactic acidosis 20.57 13.35 20 87728 33889 46564425
Normochromic normocytic anaemia 20.54 13.35 33 87715 4439 46593875
Temporomandibular joint syndrome 20.49 13.35 29 87719 3489 46594825
Simple partial seizures 20.48 13.35 13 87735 559 46597755
Sciatica 20.20 13.35 80 87668 18940 46579374
Microangiopathy 20.13 13.35 15 87733 839 46597475
Hepatic failure 19.93 13.35 20 87728 33396 46564918
Depressed mood 19.81 13.35 20 87728 33299 46565015
Panic attack 19.80 13.35 83 87665 20159 46578155
Acute myeloid leukaemia 19.79 13.35 3 87745 15775 46582539
Chronic kidney disease 19.68 13.35 138 87610 40733 46557581
Rheumatoid factor positive 19.54 13.35 7 87741 20454 46577860
Therapeutic response unexpected 19.51 13.35 3 87745 15613 46582701
Heart valve incompetence 19.49 13.35 23 87725 2312 46596002
Brain stem ischaemia 19.46 13.35 7 87741 80 46598234
Anaemia of chronic disease 19.33 13.35 21 87727 1929 46596385
Mental disorder due to a general medical condition 19.20 13.35 8 87740 139 46598175
Suicidal ideation 19.19 13.35 49 87699 56333 46541981
Stevens-Johnson syndrome 19.03 13.35 10 87738 23287 46575027
Lymphopenia 18.97 13.35 3 87745 15290 46583024
Chronic sinusitis 18.96 13.35 34 87714 4999 46593315
Arterial stenosis 18.95 13.35 13 87735 638 46597676
Gamma-glutamyltransferase increased 18.93 13.35 19 87729 31721 46566593
Rectal haemorrhage 18.91 13.35 130 87618 38125 46560189
Exostosis 18.86 13.35 52 87696 10211 46588103
Pallor 18.84 13.35 10 87738 23156 46575158
Musculoskeletal pain 18.83 13.35 68 87680 70060 46528254
Peripheral artery stenosis 18.76 13.35 12 87736 523 46597791
Glucose tolerance impaired 18.67 13.35 33 87715 4798 46593516
Myalgia 18.65 13.35 145 87603 122943 46475371
Cardiac flutter 18.61 13.35 27 87721 3322 46594992
Collagen-vascular disease 18.59 13.35 5 87743 19 46598295
Inflammation 18.52 13.35 40 87708 48741 46549573
Hypocalcaemia 18.43 13.35 14 87734 26771 46571543
Presbyoesophagus 18.38 13.35 5 87743 20 46598294
Hypertriglyceridaemia 18.33 13.35 36 87712 5668 46592646
Clostridium difficile colitis 18.32 13.35 6 87742 18547 46579767
Blood homocysteine increased 18.25 13.35 9 87739 235 46598079
Metastases to liver 18.20 13.35 7 87741 19578 46578736
Vaginal prolapse 18.11 13.35 11 87737 437 46597877
Sinus disorder 17.86 13.35 70 87678 16493 46581821
Urethral stenosis 17.61 13.35 9 87739 254 46598060
Limb injury 17.51 13.35 77 87671 19097 46579217
Atrioventricular block first degree 17.46 13.35 37 87711 6149 46592165
Duodenal ulcer haemorrhage 17.32 13.35 22 87726 2386 46595928
Foot deformity 17.29 13.35 66 87682 15359 46582955
Thyroid disorder 17.28 13.35 56 87692 12020 46586294
Radius fracture 17.22 13.35 26 87722 3316 46594998
Embolism 17.12 13.35 40 87708 7098 46591216
Actinic keratosis 16.97 13.35 21 87727 2218 46596096
Laboratory test abnormal 16.97 13.35 11 87737 22836 46575478
Enterocele 16.81 13.35 6 87742 67 46598247
Appendix disorder 16.79 13.35 16 87732 1258 46597056
Thyroid neoplasm 16.75 13.35 27 87721 3642 46594672
Anhedonia 16.70 13.35 50 87698 10285 46588029
Functional gastrointestinal disorder 16.67 13.35 25 87723 3169 46595145
Abdominal distension 16.63 13.35 76 87672 73275 46525039
Mitral valve sclerosis 16.53 13.35 7 87741 127 46598187
Menopausal symptoms 16.50 13.35 19 87729 1860 46596454
Electrocardiogram abnormal 16.50 13.35 39 87709 6973 46591341
Venous angioma of brain 16.42 13.35 4 87744 9 46598305
Synovial cyst 16.36 13.35 40 87708 7306 46591008
Right ventricular failure 16.25 13.35 5 87743 16088 46582226
Blood creatinine increased 16.24 13.35 81 87667 76322 46521992
Electrocardiogram ST segment abnormal 16.21 13.35 14 87734 968 46597346
Herpes zoster 16.18 13.35 69 87679 67803 46530511
Osteonecrosis of jaw 15.91 13.35 25 87723 34377 46563937
Body temperature increased 15.86 13.35 14 87734 24847 46573467
Myofascitis 15.85 13.35 4 87744 11 46598303
Congenital eye naevus 15.84 13.35 3 87745 0 46598314
Sternal injury 15.84 13.35 3 87745 0 46598314
Cystitis glandularis 15.84 13.35 3 87745 0 46598314
Exfoliation syndrome 15.84 13.35 3 87745 0 46598314
Viral rhinitis 15.84 13.35 3 87745 0 46598314
Abnormal behaviour 15.83 13.35 10 87738 21048 46577266
Postinfarction angina 15.82 13.35 5 87743 37 46598277
Disseminated intravascular coagulation 15.76 13.35 8 87740 18997 46579317
Arteriospasm coronary 15.66 13.35 26 87722 3595 46594719
Acquired oesophageal web 15.65 13.35 8 87740 226 46598088
Vascular insufficiency 15.58 13.35 8 87740 228 46598086
Restlessness 15.54 13.35 15 87733 25509 46572805
Wheezing 15.53 13.35 50 87698 53336 46544978
Aggression 15.51 13.35 12 87736 22732 46575582
Asthma 15.50 13.35 250 87498 91292 46507022
Gliosis 15.49 13.35 8 87740 231 46598083
Hypercoagulation 15.38 13.35 19 87729 2003 46596311
QRS axis abnormal 15.37 13.35 14 87734 1039 46597275
Glaucoma 15.35 13.35 65 87683 15856 46582458
Bundle branch block 15.33 13.35 13 87735 877 46597437
Caesarean section 15.32 13.35 6 87742 16597 46581717
Bronchial hyperreactivity 15.27 13.35 16 87732 1410 46596904
Hyperhomocysteinaemia 15.25 13.35 7 87741 155 46598159
Coagulation factor VIII level increased 15.13 13.35 4 87744 14 46598300
Hepatocellular injury 15.09 13.35 20 87728 29502 46568812
Vascular graft occlusion 15.05 13.35 7 87741 160 46598154
Menometrorrhagia 15.04 13.35 13 87735 900 46597414
Gait inability 14.97 13.35 27 87721 35176 46563138
Vertebral artery occlusion 14.97 13.35 6 87742 94 46598220
Headache 14.94 13.35 741 87007 477611 46120703
Ventricular dyskinesia 14.93 13.35 7 87741 163 46598151
Cerebrovascular insufficiency 14.85 13.35 6 87742 96 46598218
Memory impairment 14.77 13.35 85 87663 77252 46521062
Poisoning 14.77 13.35 4 87744 13990 46584324
Helicobacter gastritis 14.76 13.35 16 87732 1466 46596848
Mitral valve stenosis 14.64 13.35 14 87734 1105 46597209
Arterial disorder 14.64 13.35 14 87734 1105 46597209
Respiratory tract infection 14.62 13.35 21 87727 29951 46568363
Therapy non-responder 14.60 13.35 35 87713 41117 46557197
Hyponatraemia 14.60 13.35 121 87627 101211 46497103
Pulmonary granuloma 14.51 13.35 15 87733 1301 46597013
Abdominal strangulated hernia 14.47 13.35 6 87742 103 46598211
Skin laceration 14.46 13.35 71 87677 18431 46579883
Encephalomalacia 14.44 13.35 10 87738 498 46597816
Dyskinesia 14.37 13.35 20 87728 28905 46569409
Renal embolism 14.33 13.35 4 87744 18 46598296
Tarsal tunnel syndrome 14.32 13.35 11 87737 644 46597670
Aortic valve disease 14.30 13.35 13 87735 962 46597352
International normalised ratio increased 14.28 13.35 43 87705 46840 46551474
Jaundice 14.28 13.35 20 87728 28825 46569489
Epicondylitis 14.28 13.35 17 87731 1725 46596589
Thrombophlebitis superficial 14.21 13.35 30 87718 4973 46593341
Neuroma 14.18 13.35 9 87739 387 46597927
Urinary incontinence 14.13 13.35 97 87651 28433 46569881
Chest discomfort 13.99 13.35 243 87505 90026 46508288
Lipids increased 13.93 13.35 13 87735 995 46597319
Osteopenia 13.92 13.35 66 87682 16895 46581419
Diabetic microangiopathy 13.82 13.35 4 87744 21 46598293
Device malfunction 13.79 13.35 4 87744 13370 46584944
Cubital tunnel syndrome 13.78 13.35 7 87741 195 46598119
Eye irritation 13.76 13.35 7 87741 16607 46581707
Coronary artery surgery 13.76 13.35 5 87743 59 46598255
Pernicious anaemia 13.69 13.35 11 87737 688 46597626
Cervicitis 13.64 13.35 9 87739 414 46597900
Cough 13.63 13.35 329 87419 229920 46368394
Drug eruption 13.62 13.35 12 87736 21317 46576997
Meningioma 13.62 13.35 24 87724 3481 46594833
Gastroenteritis 13.61 13.35 85 87663 24134 46574180
Mastoiditis 13.59 13.35 11 87737 695 46597619
Hypertonic bladder 13.57 13.35 22 87726 2982 46595332
Respiratory arrest 13.45 13.35 27 87721 33789 46564525
Hypovolaemia 13.38 13.35 45 87703 9843 46588471

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coronary artery disease 3651.98 16.22 1959 70481 47753 29832285
Myocardial infarction 3093.77 16.22 2494 69946 123131 29756907
Hyperlipidaemia 1443.35 16.22 694 71746 13213 29866825
Cerebrovascular accident 1433.92 16.22 1354 71086 82123 29797915
Acute myocardial infarction 1203.28 16.22 1007 71433 51932 29828106
Hypertension 1178.83 16.22 1456 70984 119898 29760140
Chest pain 1019.54 16.22 1334 71106 116293 29763745
Angina unstable 939 16.22 499 71941 11811 29868227
Angina pectoris 841.76 16.22 642 71798 28876 29851162
Arteriosclerosis coronary artery 774.07 16.22 425 72015 10751 29869287
Coronary artery stenosis 686.87 16.22 366 72074 8704 29871334
Coronary artery occlusion 663.55 16.22 384 72056 10773 29869265
Depression 657.34 16.22 943 71497 89494 29790544
Gastrooesophageal reflux disease 639.32 16.22 568 71872 31687 29848351
Cardiovascular disorder 627.65 16.22 368 72072 10584 29869454
Mitral valve incompetence 625.50 16.22 393 72047 12841 29867197
Ventricular hypertrophy 618.53 16.22 280 72160 4607 29875431
Blood cholesterol increased 587.19 16.22 415 72025 16555 29863483
Hypercholesterolaemia 576.64 16.22 307 72133 7285 29872753
Off label use 567.18 16.22 7 72433 249283 29630755
Arteriosclerosis 566.09 16.22 343 72097 10490 29869548
Transient ischaemic attack 505.66 16.22 447 71993 24753 29855285
Death 489.70 16.22 131 72309 357152 29522886
Carotid artery stenosis 436.66 16.22 217 72223 4437 29875601
Emotional distress 407.99 16.22 324 72116 15441 29864597
Ventricular dysfunction 389.13 16.22 186 72254 3481 29876557
Cardiac disorder 382.81 16.22 477 71963 39416 29840622
Osteoarthritis 375.04 16.22 329 72111 18020 29862018
Myocardial ischaemia 369.06 16.22 318 72122 16999 29863039
Drug interaction 357.21 16.22 35 72405 199533 29680505
Injury 344.19 16.22 338 72102 21393 29858645
Tricuspid valve incompetence 343.27 16.22 230 72210 8393 29871645
Sleep apnoea syndrome 342.00 16.22 301 72139 16556 29863482
Anxiety 335.31 16.22 698 71742 89173 29790865
Cardiac failure congestive 329.54 16.22 668 71772 83739 29796299
Toxicity to various agents 309.44 16.22 34 72406 177149 29702889
Ischaemic cardiomyopathy 304.96 16.22 190 72250 6107 29873931
Rotator cuff syndrome 286.84 16.22 173 72267 5240 29874798
Peripheral vascular disorder 284.85 16.22 170 72270 5049 29874989
Pyrexia 281.13 16.22 184 72256 294305 29585733
Arthropathy 276.62 16.22 294 72146 20433 29859605
Drug ineffective 272.80 16.22 254 72186 340133 29539905
Diarrhoea 270.47 16.22 247 72193 333856 29546182
Acute kidney injury 266.92 16.22 167 72273 273675 29606363
Dilatation atrial 254.20 16.22 117 72323 2002 29878036
Neutropenia 248.01 16.22 16 72424 128524 29751514
Cardiomegaly 241.57 16.22 232 72208 14277 29865761
Dyslipidaemia 235.75 16.22 156 72284 5571 29874467
Febrile neutropenia 233.76 16.22 5 72435 106688 29773350
Back injury 229.41 16.22 129 72311 3416 29876622
Benign prostatic hyperplasia 220.81 16.22 191 72249 10256 29869782
Intervertebral disc protrusion 219.61 16.22 181 72259 9090 29870948
Diverticulum 212.93 16.22 156 72284 6577 29873461
Completed suicide 205.77 16.22 8 72432 99484 29780554
Malaise 203.29 16.22 75 72365 166887 29713151
Coronary artery restenosis 202.79 16.22 84 72356 1099 29878939
Aortic valve incompetence 202.39 16.22 134 72306 4789 29875249
Product dose omission issue 201.88 16.22 4 72436 91627 29788411
Haemorrhoids 201.85 16.22 194 72246 11947 29868091
Lacunar infarction 196.58 16.22 112 72328 3043 29876995
Hiatus hernia 181.82 16.22 145 72295 6945 29873093
Drug abuse 179.14 16.22 4 72436 82068 29797970
Rash 178.56 16.22 123 72317 191766 29688272
Carotid artery disease 177.56 16.22 72 72368 889 29879149
White blood cell count decreased 176.17 16.22 6 72434 83941 29796097
Back disorder 174.17 16.22 132 72308 5862 29874176
Hypertensive heart disease 170.11 16.22 93 72347 2327 29877711
Carpal tunnel syndrome 169.85 16.22 114 72326 4169 29875869
Intervertebral disc degeneration 164.54 16.22 121 72319 5130 29874908
Platelet count decreased 162.63 16.22 30 72410 106099 29773939
Erectile dysfunction 161.67 16.22 209 72231 17893 29862145
Gastritis 160.13 16.22 220 72220 19978 29860060
Pruritus 159.94 16.22 44 72396 118160 29761878
Chronic obstructive pulmonary disease 157.58 16.22 346 72094 45780 29834258
Pneumonia 153.00 16.22 367 72073 333939 29546099
Decreased appetite 150.49 16.22 88 72352 149822 29730216
General physical health deterioration 149.43 16.22 30 72410 99914 29780124
Nausea 148.06 16.22 311 72129 296646 29583392
Intermittent claudication 146.47 16.22 82 72358 2152 29877886
Coronary artery thrombosis 146.16 16.22 81 72359 2083 29877955
Thrombocytopenia 145.45 16.22 75 72365 136969 29743069
Sepsis 145.44 16.22 87 72353 146308 29733730
Large intestine polyp 144.48 16.22 124 72316 6585 29873453
Pancytopenia 144.09 16.22 18 72422 85034 29795004
Sinus bradycardia 143.93 16.22 159 72281 11536 29868502
Malignant neoplasm progression 142.34 16.22 8 72432 72279 29807759
Disease progression 140.06 16.22 15 72425 79859 29800179
Organ failure 139.79 16.22 79 72361 2112 29877926
Spinal osteoarthritis 137.25 16.22 118 72322 6281 29873757
Dyspepsia 132.58 16.22 252 72188 30077 29849961
Type 2 diabetes mellitus 130.69 16.22 163 72277 13459 29866579
Vomiting 129.17 16.22 208 72232 219610 29660428
Non-cardiac chest pain 127.30 16.22 94 72346 4010 29876028
Cardiac murmur 126.63 16.22 116 72324 6718 29873320
Ventricular extrasystoles 125.93 16.22 147 72293 11327 29868711
Carotid bruit 122.76 16.22 39 72401 220 29879818
Rhinitis allergic 119.50 16.22 79 72361 2815 29877223
Ventricular tachycardia 119.12 16.22 210 72230 23652 29856386
Multiple injuries 119.03 16.22 69 72371 1938 29878100
Adverse event 118.44 16.22 165 72275 15176 29864862
Arterial occlusive disease 117.44 16.22 89 72351 3951 29876087
Thrombosis 117.12 16.22 292 72148 41939 29838099
Cervicobrachial syndrome 115.99 16.22 40 72400 302 29879736
Acute coronary syndrome 113.89 16.22 152 72288 13421 29866617
Carotid artery occlusion 113.20 16.22 67 72373 1958 29878080
Lumbar radiculopathy 112.98 16.22 51 72389 832 29879206
Radiculopathy 112.89 16.22 74 72366 2599 29877439
Musculoskeletal chest pain 110.90 16.22 123 72317 8962 29871076
Haemoglobin decreased 110.22 16.22 70 72370 114028 29766010
Dilatation ventricular 107.87 16.22 72 72368 2608 29877430
Spinal stenosis 107.73 16.22 87 72353 4242 29875796
Condition aggravated 105.17 16.22 107 72333 137759 29742279
Joint injury 104.05 16.22 103 72337 6574 29873464
Renal impairment 103.70 16.22 37 72403 84147 29795891
Multiple organ dysfunction syndrome 101.49 16.22 16 72424 63471 29816567
Diabetes mellitus 98.24 16.22 272 72168 41593 29838445
Arrhythmia 97.97 16.22 235 72205 32934 29847104
Meniscus injury 95.87 16.22 61 72379 2034 29878004
Bronchitis 95.60 16.22 258 72182 38867 29841171
Blood triglycerides increased 95.38 16.22 142 72298 13875 29866163
Septic shock 95.22 16.22 19 72421 63588 29816450
Neck injury 94.29 16.22 49 72391 1103 29878935
Peptic ulcer 94.05 16.22 67 72373 2701 29877337
Erythema 93.77 16.22 35 72405 77416 29802622
Road traffic accident 91.43 16.22 155 72285 16916 29863122
Aortic valve sclerosis 89.87 16.22 44 72396 869 29879169
Renal cyst 89.50 16.22 103 72337 7814 29872224
Chronic fatigue syndrome 89.28 16.22 32 72408 274 29879764
Plasma cell myeloma 88.87 16.22 12 72428 53450 29826588
Fatigue 88.67 16.22 437 72003 320236 29559802
Acne cystic 88.16 16.22 36 72404 453 29879585
Angiopathy 88.16 16.22 73 72367 3688 29876350
Hospitalisation 86.93 16.22 5 72435 44314 29835724
Obesity 86.29 16.22 105 72335 8450 29871588
Anxiety disorder 85.94 16.22 50 72390 1414 29878624
Cerebrovascular disorder 85.75 16.22 56 72384 1954 29878084
Rhabdomyolysis 85.31 16.22 24 72416 63556 29816482
Weight decreased 82.83 16.22 149 72291 150772 29729266
Aortic arteriosclerosis 82.79 16.22 72 72368 3892 29876146
Interstitial lung disease 82.12 16.22 22 72418 60175 29819863
Blood creatinine increased 81.65 16.22 61 72379 91314 29788724
Leukopenia 81.54 16.22 18 72422 56141 29823897
Somnolence 78.52 16.22 71 72369 96692 29783346
Barrett's oesophagus 78.44 16.22 34 72406 501 29879537
Ventricular hypokinesia 74.97 16.22 70 72370 4153 29875885
Mitral valve prolapse 73.58 16.22 34 72406 587 29879451
Mitral valve calcification 73.50 16.22 30 72410 377 29879661
Aortic aneurysm 73.45 16.22 84 72356 6329 29873709
Confusional state 73.18 16.22 134 72306 134700 29745338
Intentional overdose 72.15 16.22 8 72432 41473 29838565
Palpitations 71.82 16.22 211 72229 33362 29846676
Back pain 71.77 16.22 459 71981 102137 29777901
Cardiac valve disease 70.71 16.22 58 72382 2891 29877147
Bursitis 70.08 16.22 70 72370 4516 29875522
Infusion related reaction 67.66 16.22 9 72431 40555 29839483
Muscular weakness 67.18 16.22 35 72405 63610 29816428
Cerebral artery occlusion 66.54 16.22 34 72406 738 29879300
Low density lipoprotein increased 66.40 16.22 64 72376 3952 29876086
Ventricular fibrillation 66.39 16.22 126 72314 15012 29865026
Inappropriate schedule of product administration 65.82 16.22 9 72431 39719 29840319
Dressler's syndrome 65.44 16.22 16 72424 25 29880013
Epicondylitis 65.06 16.22 28 72412 405 29879633
Intentional product misuse 64.79 16.22 5 72435 34662 29845376
Exostosis 64.69 16.22 59 72381 3396 29876642
Ligament sprain 64.57 16.22 54 72386 2766 29877272
Anaemia postoperative 64.19 16.22 30 72410 532 29879506
Incorrect dose administered 63.95 16.22 3 72437 31683 29848355
Aneurysm 63.52 16.22 44 72396 1695 29878343
Oxygen saturation decreased 62.90 16.22 14 72426 43426 29836612
Brain stem infarction 62.19 16.22 39 72401 1267 29878771
Hypoaesthesia 62.15 16.22 278 72162 53952 29826086
Electrocardiogram QT prolonged 62.10 16.22 7 72433 35828 29844210
Hypotension 62.04 16.22 262 72178 200303 29679735
Diverticulum intestinal 61.36 16.22 56 72384 3226 29876812
Mucosal inflammation 61.18 16.22 3 72437 30491 29849547
Alanine aminotransferase increased 60.84 16.22 54 72386 74222 29805816
Lumbar spinal stenosis 60.48 16.22 50 72390 2520 29877518
Hallucination 59.64 16.22 22 72418 49037 29831001
Bundle branch block right 59.28 16.22 79 72361 6963 29873075
Intervertebral disc disorder 58.61 16.22 42 72398 1709 29878329
Stomatitis 58.21 16.22 10 72430 37269 29842769
Dehydration 57.52 16.22 134 72306 123405 29756633
Heart rate irregular 57.47 16.22 105 72335 12154 29867884
C-reactive protein increased 57.22 16.22 17 72423 43456 29836582
Chills 56.41 16.22 55 72385 72283 29807755
Hepatic function abnormal 55.94 16.22 16 72424 41929 29838109
Cardiomyopathy 55.56 16.22 117 72323 15026 29865012
Silent myocardial infarction 54.16 16.22 24 72416 374 29879664
Essential hypertension 53.59 16.22 46 72394 2442 29877596
Chest discomfort 53.51 16.22 235 72205 45245 29834793
Prostate examination abnormal 53.30 16.22 23 72417 335 29879703
Therapeutic product effect incomplete 53.00 16.22 9 72431 33825 29846213
Diabetic neuropathy 52.50 16.22 56 72384 3903 29876135
Diastolic dysfunction 52.42 16.22 58 72382 4213 29875825
Jaundice 52.33 16.22 8 72432 32478 29847560
Nephrolithiasis 52.17 16.22 155 72285 24655 29855383
Neck pain 52.02 16.22 139 72301 20805 29859233
Lactic acidosis 51.87 16.22 7 72433 31206 29848832
Psoriasis 51.77 16.22 19 72421 42487 29837551
Prescribed overdose 51.59 16.22 82 72358 8479 29871559
Costochondritis 50.69 16.22 25 72415 502 29879536
Aortic valve stenosis 50.64 16.22 38 72402 1661 29878377
Hyponatraemia 50.22 16.22 53 72387 67149 29812889
Gamma-glutamyltransferase increased 50.19 16.22 6 72434 29344 29850694
Labile hypertension 50.09 16.22 15 72425 67 29879971
Limb injury 49.95 16.22 83 72357 8908 29871130
Hernia 49.35 16.22 81 72359 8605 29871433
Urticaria 49.34 16.22 36 72404 54570 29825468
Gout 49.31 16.22 121 72319 17194 29862844
Suicide attempt 48.94 16.22 14 72426 36683 29843355
Unresponsive to stimuli 48.84 16.22 4 72436 26415 29853623
Heart injury 48.69 16.22 35 72405 1431 29878607
Aspartate aminotransferase increased 48.55 16.22 49 72391 63373 29816665
Gallbladder disorder 46.62 16.22 64 72376 5803 29874235
Cerebral infarction 46.47 16.22 155 72285 26218 29853820
Bundle branch block left 46.31 16.22 60 72380 5144 29874894
Hyperkalaemia 46.11 16.22 55 72385 65955 29814083
Laryngeal pain 46.11 16.22 45 72395 2822 29877216
Cerebellar infarction 45.67 16.22 37 72403 1812 29878226
Cholestasis 45.51 16.22 4 72436 24946 29855092
Blood bilirubin increased 45.26 16.22 16 72424 36620 29843418
Supraventricular extrasystoles 45.00 16.22 47 72393 3197 29876841
Onychomycosis 44.59 16.22 39 72401 2124 29877914
Pulmonary valve incompetence 44.11 16.22 25 72415 672 29879366
Panic disorder 43.55 16.22 30 72410 1145 29878893
Tremor 43.48 16.22 72 72368 75291 29804747
Spinal disorder 43.34 16.22 47 72393 3338 29876700
Upper respiratory tract infection 42.79 16.22 155 72285 27321 29852717
Cytomegalovirus infection 42.63 16.22 4 72436 23670 29856368
Angioedema 42.50 16.22 15 72425 34369 29845669
Congestive cardiomyopathy 42.05 16.22 65 72375 6562 29873476
Infection 41.95 16.22 78 72362 77996 29802042
High density lipoprotein decreased 41.85 16.22 45 72395 3165 29876873
Unevaluable event 40.80 16.22 13 72427 31772 29848266
Nasopharyngitis 40.08 16.22 50 72390 58799 29821239
Plantar fasciitis 40.04 16.22 26 72414 898 29879140
Ischaemia 40.03 16.22 52 72388 4469 29875569
Rash maculo-papular 39.29 16.22 7 72433 25411 29854627
Ascites 39.03 16.22 19 72421 35902 29844136
Metabolic acidosis 38.93 16.22 21 72419 37440 29842598
Hypertensive cardiomyopathy 38.86 16.22 15 72425 161 29879877
Cerumen impaction 38.82 16.22 20 72420 442 29879596
International normalised ratio increased 38.73 16.22 35 72405 47704 29832334
Oesophageal disorder 38.50 16.22 28 72412 1166 29878872
Mobility decreased 38.41 16.22 8 72432 25991 29854047
Gait disturbance 38.18 16.22 77 72363 74700 29805338
Sinus disorder 38.03 16.22 60 72380 6165 29873873
Tendonitis 37.88 16.22 69 72371 7967 29872071
Wrong technique in product usage process 37.81 16.22 14 72426 31141 29848897
Post-traumatic stress disorder 37.13 16.22 31 72409 1584 29878454
Myofascial pain syndrome 37.11 16.22 18 72422 348 29879690
Red blood cell count decreased 37.07 16.22 9 72431 26312 29853726
Skin laceration 36.80 16.22 83 72357 11168 29868870
Asthenia 36.79 16.22 350 72090 220940 29659098
Sinusitis 36.73 16.22 169 72271 33176 29846862
Multi-organ disorder 36.66 16.22 27 72413 1147 29878891
Delirium 36.42 16.22 27 72413 40604 29839434
Coronary artery insufficiency 36.40 16.22 13 72427 110 29879928
Dementia Alzheimer's type 36.39 16.22 19 72421 432 29879606
Acute sinusitis 36.38 16.22 29 72411 1387 29878651
Agranulocytosis 36.27 16.22 5 72435 21937 29858101
Ejection fraction decreased 35.97 16.22 99 72341 15076 29864962
Spondylolisthesis 35.95 16.22 23 72417 774 29879264
Electrocardiogram ST-T change 35.93 16.22 21 72419 599 29879439
Glucose tolerance impaired 35.72 16.22 39 72401 2791 29877247
Prostatitis 35.24 16.22 51 72389 4856 29875182
Emotional disorder 35.21 16.22 52 72388 5042 29874996
Transaminases increased 35.10 16.22 7 72433 23450 29856588
Anaphylactic reaction 34.94 16.22 12 72428 27970 29852068
Meniere's disease 34.93 16.22 11 72429 60 29879978
Lymphocyte count decreased 34.90 16.22 3 72437 19052 29860986
Hyperhomocysteinaemia 34.80 16.22 14 72426 169 29879869
Eosinophilia 34.47 16.22 6 72434 22154 29857884
Cyst 34.37 16.22 45 72395 3898 29876140
Patellofemoral pain syndrome 34.32 16.22 13 72427 132 29879906
Dupuytren's contracture 34.21 16.22 8 72432 9 29880029
Seborrhoeic keratosis 33.91 16.22 24 72416 957 29879081
Aggression 33.77 16.22 24 72416 36883 29843155
Left ventricular end-diastolic pressure increased 33.56 16.22 12 72428 102 29879936
Blood pressure inadequately controlled 33.45 16.22 36 72404 2534 29877504
Blood creatine phosphokinase increased 33.41 16.22 34 72406 43814 29836224
Trigger finger 33.22 16.22 21 72419 692 29879346
Agitation 32.75 16.22 50 72390 54023 29826015
Peripheral venous disease 32.66 16.22 32 72408 2016 29878022
Ischaemic stroke 32.63 16.22 100 72340 16175 29863863
Nocturia 32.58 16.22 66 72374 8246 29871792
Cardiac aneurysm 32.56 16.22 20 72420 626 29879412
Acute myeloid leukaemia 32.53 16.22 3 72437 18003 29862035
Skin exfoliation 32.48 16.22 8 72432 23164 29856874
Lung neoplasm 32.28 16.22 47 72393 4499 29875539
Atrioventricular block first degree 32.25 16.22 53 72387 5635 29874403
Sinus node dysfunction 32.17 16.22 43 72397 3800 29876238
Feeling abnormal 32.01 16.22 55 72385 56701 29823337
Sacroiliitis 31.97 16.22 22 72418 838 29879200
Vertebral artery occlusion 31.45 16.22 13 72427 169 29879869
Therapy non-responder 31.36 16.22 16 72424 29437 29850601
Hepatic failure 31.32 16.22 22 72418 34021 29846017
Atelectasis 31.28 16.22 98 72342 16040 29863998
Atrial fibrillation 31.22 16.22 399 72041 107725 29772313
Accelerated hypertension 31.20 16.22 14 72426 225 29879813
Drug level increased 30.77 16.22 4 72436 18350 29861688
Arthralgia 30.74 16.22 480 71960 135311 29744727
Peritonitis 30.71 16.22 7 72433 21368 29858670
Disseminated intravascular coagulation 30.42 16.22 8 72432 22163 29857875
Depression postoperative 30.16 16.22 6 72434 0 29880038
Blood pressure decreased 30.00 16.22 42 72398 47033 29833005
Flushing 29.97 16.22 17 72423 29475 29850563
Generalised anxiety disorder 29.61 16.22 19 72421 643 29879395
Blood alkaline phosphatase increased 29.43 16.22 20 72420 31467 29848571
Incision site complication 29.30 16.22 15 72425 327 29879711
Synovial cyst 29.21 16.22 28 72412 1717 29878321
Blood lactate dehydrogenase increased 29.10 16.22 7 72433 20594 29859444
Duodenitis 29.03 16.22 42 72398 3998 29876040
Ligament injury 28.97 16.22 15 72425 335 29879703
Chondromalacia 28.94 16.22 8 72432 25 29880013
Coronary artery reocclusion 28.93 16.22 11 72429 113 29879925
Cataract 28.91 16.22 117 72323 21718 29858320
Flank pain 28.90 16.22 52 72388 5946 29874092
Ulnar nerve injury 28.48 16.22 8 72432 27 29880011
Influenza 28.38 16.22 38 72402 43360 29836678
Ureterolithiasis 28.23 16.22 28 72412 1791 29878247
Rectal polyp 28.16 16.22 18 72422 605 29879433
Pneumocystis jirovecii pneumonia 28.07 16.22 4 72436 17116 29862922
Hepatotoxicity 28.03 16.22 5 72435 18140 29861898
Abnormal behaviour 27.16 16.22 14 72426 25609 29854429
Inguinal hernia 27.08 16.22 56 72384 7099 29872939
Iliac artery stenosis 26.99 16.22 10 72430 95 29879943
Neutrophil count increased 26.53 16.22 3 72437 15320 29864718
Lethargy 26.46 16.22 34 72406 39485 29840553
Sexual dysfunction 26.37 16.22 50 72390 5951 29874087
Epilepsy 26.33 16.22 8 72432 20161 29859877
Drug abuser 26.30 16.22 42 72398 4359 29875679
Gastritis erosive 26.21 16.22 48 72392 5565 29874473
Gastric disorder 26.20 16.22 70 72370 10473 29869565
Retinal vein occlusion 26.07 16.22 25 72415 1534 29878504
Homocystinaemia 26.02 16.22 6 72434 6 29880032
Ischaemic cerebral infarction 25.97 16.22 20 72420 909 29879129
Nephrosclerosis 25.88 16.22 19 72421 803 29879235
Anaemia 25.88 16.22 351 72089 207641 29672397
Sciatica 25.84 16.22 45 72395 5016 29875022
Gouty arthritis 25.82 16.22 21 72419 1034 29879004
Subdural haematoma 25.73 16.22 7 72433 18965 29861073
Tachypnoea 25.70 16.22 3 72437 14949 29865089
Hypoglycaemia 25.58 16.22 53 72387 50928 29829110
Migraine without aura 25.14 16.22 5 72435 0 29880038
Spondylolysis 25.06 16.22 7 72433 23 29880015
Pneumonitis 24.92 16.22 18 72422 27436 29852602
Aortic dilatation 24.63 16.22 19 72421 866 29879172
Laboratory test abnormal 24.49 16.22 6 72434 17436 29862602
Restlessness 24.47 16.22 12 72428 22587 29857451
Pancreatitis acute 24.45 16.22 16 72424 25679 29854359
Respiratory failure 24.42 16.22 143 72297 100499 29779539
Post procedural fever 24.34 16.22 11 72429 180 29879858
Blood urea increased 24.28 16.22 24 72416 31357 29848681
Dysgeusia 24.21 16.22 15 72425 24786 29855252
Rash erythematous 24.20 16.22 12 72428 22440 29857598
Acrochordon 24.15 16.22 13 72427 315 29879723
Cerebral ischaemia 24.03 16.22 49 72391 6151 29873887
Lumbosacral radiculopathy 23.88 16.22 9 72431 90 29879948
Hypophagia 23.79 16.22 12 72428 22224 29857814
Lower respiratory tract infection 23.62 16.22 18 72422 26696 29853342
Myelodysplastic syndrome 23.53 16.22 8 72432 18770 29861268
Polyp 23.53 16.22 34 72406 3232 29876806
Depressed level of consciousness 23.47 16.22 35 72405 38187 29841851
Epistaxis 23.41 16.22 59 72381 52922 29827116
Swelling face 23.36 16.22 11 72429 21193 29858845
Sinus arrhythmia 23.31 16.22 17 72423 711 29879327
Post laminectomy syndrome 23.04 16.22 11 72429 205 29879833
Peripheral artery stenosis 22.93 16.22 18 72422 842 29879196
Oedema peripheral 22.76 16.22 371 72069 105461 29774577
Dry skin 22.73 16.22 13 72427 22441 29857597
Sudden cardiac death 22.69 16.22 36 72404 3716 29876322
Colon adenoma 22.61 16.22 21 72419 1237 29878801
Vertebrobasilar insufficiency 22.58 16.22 8 72432 66 29879972
Vertigo positional 22.58 16.22 17 72423 747 29879291
Platelet aggregation increased 22.57 16.22 7 72433 36 29880002
Loss of personal independence in daily activities 22.48 16.22 12 72428 21523 29858515
Pulmonary embolism 22.39 16.22 288 72152 77847 29802191
Anhedonia 22.27 16.22 57 72383 8312 29871726
Major depression 22.16 16.22 37 72403 3985 29876053
Coma 22.08 16.22 40 72400 40409 29839629
Coronary artery surgery 21.91 16.22 9 72431 115 29879923
Acute respiratory distress syndrome 21.82 16.22 15 72425 23457 29856581
Retinal artery embolism 21.81 16.22 7 72433 41 29879997
Helicobacter infection 21.70 16.22 26 72414 2058 29877980
Tobacco abuse 21.68 16.22 13 72427 389 29879649
Cervical spinal stenosis 21.64 16.22 19 72421 1040 29878998
Gastric ulcer 21.61 16.22 83 72357 15038 29865000
Dyskinesia 21.60 16.22 13 72427 21821 29858217
Vascular graft occlusion 21.49 16.22 15 72425 585 29879453
Hepatocellular injury 21.47 16.22 18 72422 25453 29854585
Intracardiac thrombus 21.43 16.22 28 72412 2420 29877618
Respiratory distress 21.43 16.22 29 72411 32943 29847095
Hypercoagulation 21.39 16.22 19 72421 1056 29878982
Stress 21.14 16.22 101 72339 20134 29859904
Postpericardiotomy syndrome 21.00 16.22 7 72433 47 29879991
Device occlusion 20.97 16.22 46 72394 6074 29873964
Blood homocysteine increased 20.91 16.22 11 72429 254 29879784
Renal artery stenosis 20.91 16.22 24 72416 1815 29878223
Pancreatitis 20.90 16.22 35 72405 36455 29843583
Cerebral atrophy 20.81 16.22 38 72402 4395 29875643
Ingrowing nail 20.78 16.22 17 72423 844 29879194
Constipation 20.72 16.22 174 72266 112732 29767306
Dry mouth 20.71 16.22 15 72425 22835 29857203
Umbilical hernia 20.61 16.22 34 72406 3627 29876411
Pulmonary hypertension 20.60 16.22 96 72344 18940 29861098
Influenza like illness 20.49 16.22 19 72421 25586 29854452
Accident at work 20.37 16.22 15 72425 637 29879401
Pallor 20.17 16.22 13 72427 21036 29859002
Epidermal naevus 20.11 16.22 4 72436 0 29880038
Arterial disorder 20.04 16.22 19 72421 1149 29878889
Oesophageal spasm 19.74 16.22 13 72427 460 29879578
Hepatic encephalopathy 19.70 16.22 5 72435 14187 29865851
Bladder obstruction 19.68 16.22 14 72426 563 29879475
Postinfarction angina 19.67 16.22 5 72435 10 29880028
Nervousness 19.63 16.22 68 72372 11720 29868318
Neurotoxicity 19.58 16.22 4 72436 13178 29866860
Nasal turbinate hypertrophy 19.42 16.22 7 72433 61 29879977
Hypocalcaemia 19.42 16.22 14 72426 21362 29858676
Skin discolouration 19.33 16.22 7 72433 15787 29864251
Inflammation 19.27 16.22 15 72425 22011 29858027
Joint dislocation 19.20 16.22 31 72409 3247 29876791
Lipids increased 19.18 16.22 17 72423 942 29879096
Colitis 19.14 16.22 28 72412 30792 29849246
Abdominal pain 19.06 16.22 223 72217 135431 29744607
Muscle strain 19.03 16.22 33 72407 3666 29876372
Helicobacter test positive 18.99 16.22 13 72427 491 29879547
Blood pressure increased 18.90 16.22 261 72179 71667 29808371
Calcinosis 18.90 16.22 15 72425 713 29879325
Aortic valve calcification 18.88 16.22 11 72429 312 29879726
Dermal cyst 18.86 16.22 20 72420 1384 29878654
Ulcer 18.85 16.22 47 72393 6744 29873294
Groin pain 18.75 16.22 38 72402 4748 29875290
Intervertebral disc displacement 18.70 16.22 9 72431 171 29879867
Prostatic disorder 18.69 16.22 28 72412 2750 29877288
Migraine 18.67 16.22 71 72369 12803 29867235
Glaucoma 18.67 16.22 43 72397 5865 29874173
Mitral valve disease 18.48 16.22 18 72422 1126 29878912
Myocardial rupture 18.37 16.22 9 72431 178 29879860
Intentional self-injury 18.34 16.22 5 72435 13527 29866511
Insomnia 18.17 16.22 322 72118 93014 29787024
Respiratory depression 18.14 16.22 3 72437 11500 29868538
Stevens-Johnson syndrome 18.01 16.22 10 72430 17546 29862492
Nail avulsion 18.00 16.22 5 72435 16 29880022
Lipoma 17.96 16.22 20 72420 1463 29878575
Postoperative thoracic procedure complication 17.88 16.22 4 72436 3 29880035
Peritonitis bacterial 17.87 16.22 3 72437 11375 29868663
Productive cough 17.84 16.22 28 72412 29925 29850113
Neuroma 17.67 16.22 7 72433 81 29879957
Prostatism 17.64 16.22 10 72430 269 29879769
Adverse drug reaction 17.56 16.22 18 72422 23127 29856911
Metabolic syndrome 17.53 16.22 20 72420 1502 29878536
Coronary ostial stenosis 17.51 16.22 7 72433 83 29879955
Therapeutic product effect decreased 17.49 16.22 27 72413 29049 29850989
Irritable bowel syndrome 17.41 16.22 28 72412 2924 29877114
Hand fracture 17.29 16.22 21 72419 1686 29878352
Chest expansion decreased 17.27 16.22 8 72432 139 29879899
Extrasystoles 17.23 16.22 32 72408 3750 29876288
Chromaturia 17.21 16.22 6 72434 13859 29866179
Abdominal distension 17.17 16.22 55 72385 45654 29834384
Benign abdominal neoplasm 17.08 16.22 7 72433 89 29879949
Device related infection 17.01 16.22 10 72430 17005 29863033
Labyrinthitis 16.76 16.22 15 72425 842 29879196
Azotaemia 16.72 16.22 37 72403 4915 29875123
Drug intolerance 16.67 16.22 55 72385 45236 29834802
Diabetic ketoacidosis 16.55 16.22 9 72431 15977 29864061
Blood albumin decreased 16.42 16.22 5 72435 12587 29867451
Cardiolipin antibody positive 16.40 16.22 5 72435 24 29880014
Pulmonary congestion 16.39 16.22 66 72374 12221 29867817
Dyspnoea paroxysmal nocturnal 16.37 16.22 17 72423 1148 29878890
Cholelithiasis 16.33 16.22 94 72346 20131 29859907
Bundle branch block 16.29 16.22 15 72425 874 29879164
QRS axis abnormal 16.29 16.22 17 72423 1155 29878883
Carpal tunnel decompression 16.29 16.22 6 72434 56 29879982
Therapeutic response decreased 16.25 16.22 21 72419 24328 29855710

Pharmacologic Action:

SourceCodeDescription
ATC M01AH02 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Coxibs
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D052246 Cyclooxygenase 2 Inhibitors
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drugs
CHEBI has role CHEBI:50629 cyclooxygenase-2 inhibitor

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Migraine indication 37796009 DOID:6364
Rheumatoid arthritis indication 69896004 DOID:7148
Dysmenorrhea indication 266599000
Osteoarthritis indication 396275006
Juvenile rheumatoid arthritis indication 410795001

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 6.51 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 5.77 CHEMBL
Prostaglandin E2 receptor EP2 subtype GPCR Ki 7.47 PDSP
Prostaglandin G/H synthase 1 Enzyme IC50 4.63 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 6.52 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 7.92 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 6.12 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.94 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 6.37 CHEMBL

External reference:

IDSource
4021160 VUID
N0000148611 NUI
D00568 KEGG_DRUG
4021160 VANDF
C0762662 UMLSCUI
CHEBI:8887 CHEBI
RCX PDB_CHEM_ID
CHEMBL122 ChEMBL_ID
2893 IUPHAR_LIGAND_ID
C116926 MESH_SUPPLEMENTAL_RECORD_UI
7768 INN_ID
DB00533 DRUGBANK_ID
0QTW8Z7MCR UNII
5090 PUBCHEM_CID
232158 RXNORM
30883 MMSL
8220 MMSL
d04433 MMSL
007787 NDDF
116095002 SNOMEDCT_US
387008005 SNOMEDCT_US

Pharmaceutical products:

None