denileukin diftitox 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
interleukin-2 analogues and derivatives	5087	173146-27-5

Description:

Molecule

Description

Synonyms:

denileukin diftitox
ontak
E7272
E7777

more potent, truncated form of DAB(486)-IL-2; inhibit HIV-1 RNA production in infected cells

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 5, 1999	FDA	EISAI INC
March 23, 2021	PMDA	Eisai Co., Ltd.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L01XX29	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Other antineoplastic agents
FDA CS	M0006522	Diphtheria Toxin
FDA CS	M0011506	Interleukin-2
FDA CS	M0018640	Recombinant Fusion Proteins
MeSH PA	D000970	Antineoplastic Agents
FDA EPC	N0000177912	CD25-directed Cytotoxin

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Refractory peripheral T-cell lymphoma	indication	109977009
Primary cutaneous T-cell lymphoma	indication	400122007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Interleukin-2 receptor	Membrane receptor	P01589 P14784 P31785	IL2RA_HUMAN IL2RB_HUMAN IL2RG_HUMAN	ANTIBODY BINDING				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
25E79B5CTM	UNII
D03682	KEGG_DRUG
C0717670	UMLSCUI
CHEMBL1201550	ChEMBL_ID
DB00004	DRUGBANK_ID
7680	INN_ID
C078456	MESH_SUPPLEMENTAL_RECORD_UI
7044	IUPHAR_LIGAND_ID
214470	RXNORM
14092	MMSL
7958	MMSL
d04386	MMSL
007748	NDDF
125700002	SNOMEDCT_US
398881002	SNOMEDCT_US

Pharmaceutical products:

None