lumiracoxib Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
selective cyclo-oxygenase inhibitors 1618 220991-20-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • joicela
  • lumiracoxib
  • prexige
A selective non-steroidal anti-inflammatory drug (NSAID) that belongs to the group cyclo-oxygenase 2 (COX-2) inhibitors. It blocks the COX-2 enzyme, resulting in a reduction in the production of prostaglandins, substances that are involved in the inflammation process.
  • Molecular weight: 293.72
  • Formula: C15H13ClFNO2
  • CLOGP: 4.51
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 49.33
  • ALOGS: -4.73
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 12, 2003 UK Medicines and Healthcare Products Regulatory Agency (MHRA) Novartis Pharmaceuticals UK Limited

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AH06 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Coxibs
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D052246 Cyclooxygenase 2 Inhibitors
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Osteoarthritis indication 396275006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.24 acidic
pKa2 0.42 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR Ki 6.49 CHEMBL SCIENTIFIC LITERATURE
Prostaglandin G/H synthase 1 Enzyme IC50 8.15 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 7.40 CHEMBL

External reference:

IDSource
D03714 KEGG_DRUG
422506000 SNOMEDCT_US
424967004 SNOMEDCT_US
011158 NDDF
CHEBI:73044 CHEBI
CHEMBL404108 ChEMBL_ID
V91T9204HU UNII
8151 INN_ID
LUR PDB_CHEM_ID
DB01283 DRUGBANK_ID
151166 PUBCHEM_CID
2897 IUPHAR_LIGAND_ID
C473384 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None