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polmacoxib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| selective cyclo-oxygenase inhibitors | 5240 | 301692-76-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Polmacoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis. It is a selective COX-2 inhibitor.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,MAPK7,MAPKAPK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIK3CG,PRKDC,TEK | 22 | |||
| kinase-selectivity-class | AXL | 1 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 5, 2015 | Korean Food and Drug Administration (KFDA) | CrystalGenomics |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | M01AH07 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Coxibs |
| CHEBI has role | CHEBI:67079 | anti-inflammatory agent |
Related Drugs by ATC class:
M01AH Coxibs 6 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Osteoarthritis | indication | 396275006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.72 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 8.08 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Prostaglandin G/H synthase 1 | Enzyme | INHIBITOR | IC50 | 6.08 | SCIENTIFIC LITERATURE | ||||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 8.52 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| IJ34D6YPAO | UNII |
| C4519118 | UMLSCUI |
| CHEBI:748655 | CHEBI |
| 949 | PDB_CHEM_ID |
| CHEMBL166863 | ChEMBL_ID |
| 9841854 | PUBCHEM_CID |
| DB12399 | DRUGBANK_ID |
| D10656 | KEGG_DRUG |
| 9898 | INN_ID |
| C000599293 | MESH_SUPPLEMENTAL_RECORD_UI |
| 8316 | IUPHAR_LIGAND_ID |
| 1299094002 | SNOMEDCT_US |
| 018797 | NDDF |
Pharmaceutical products:
None