polmacoxib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
selective cyclo-oxygenase inhibitors 5240 301692-76-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • polmacoxib
  • acelex
  • CG-100649
  • CG100649
Polmacoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis. It is a selective COX-2 inhibitor.
  • Molecular weight: 361.39
  • Formula: C18H16FNO4S
  • CLOGP: 2.28
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 86.46
  • ALOGS: -5.13
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 5, 2015 Korean Food and Drug Administration (KFDA) CrystalGenomics

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AH07 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Coxibs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Osteoarthritis indication 396275006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.72 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 8.08 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 6.08 SCIENTIFIC LITERATURE
Prostaglandin G/H synthase 1 Enzyme IC50 8.52 CHEMBL

External reference:

IDSource
IJ34D6YPAO UNII
C4519118 UMLSCUI
949 PDB_CHEM_ID
CHEMBL166863 ChEMBL_ID
9841854 PUBCHEM_CID
DB12399 DRUGBANK_ID
D10656 KEGG_DRUG
8316 IUPHAR_LIGAND_ID
018797 NDDF
C000599293 MESH_SUPPLEMENTAL_RECORD_UI
9898 INN_ID

Pharmaceutical products:

None