polmacoxib Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
selective cyclo-oxygenase inhibitors 5240 301692-76-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • polmacoxib
  • acelex
  • CG-100649
  • CG100649
Polmacoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis. It is a selective COX-2 inhibitor.
  • Molecular weight: 361.39
  • Formula: C18H16FNO4S
  • CLOGP: 2.28
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 86.46
  • ALOGS: -5.13
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 5, 2015 Korean Food and Drug Administration (KFDA) CrystalGenomics

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AH07 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Coxibs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Osteoarthritis indication 396275006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.72 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 8.08 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 6.08 SCIENTIFIC LITERATURE

External reference:

IDSource
CHEMBL166863 ChEMBL_ID
D10656 KEGG_DRUG
IJ34D6YPAO UNII
9898 INN_ID
949 PDB_CHEM_ID
DB12399 DRUGBANK_ID
9841854 PUBCHEM_CID
8316 IUPHAR_LIGAND_ID
C000599293 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None