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etoricoxib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| selective cyclo-oxygenase inhibitors | 1113 | 202409-33-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A sulfone and pyridine derivative that acts as a cyclooxygenase-2 inhibitor. It is used as a NSAID for the treatment of pain associated with RHEUMATOID ARTHRITIS and ANKYLOSING SPONDYLITIS. It is also used for the short-term treatment of moderate postoperative dental pain.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 60 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.14 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 4.78 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 1.50 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 0.79 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.08 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 26 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1998 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug interaction | 65.12 | 15.19 | 118 | 10772 | 276335 | 90341222 |
| Lung adenocarcinoma stage IV | 63.85 | 15.19 | 14 | 10876 | 436 | 90617121 |
| Labelled drug-drug interaction medication error | 62.75 | 15.19 | 32 | 10858 | 14550 | 90603007 |
| Spinal osteoarthritis | 54.58 | 15.19 | 32 | 10858 | 19116 | 90598441 |
| Fixed eruption | 53.71 | 15.19 | 16 | 10874 | 1714 | 90615843 |
| Inflammatory marker increased | 50.96 | 15.19 | 24 | 10866 | 9190 | 90608367 |
| Thrombocytosis | 50.67 | 15.19 | 22 | 10868 | 6979 | 90610578 |
| Axial spondyloarthritis | 48.85 | 15.19 | 12 | 10878 | 619 | 90616938 |
| Ophthalmic herpes zoster | 46.21 | 15.19 | 16 | 10874 | 2772 | 90614785 |
| Cervical dysplasia | 43.97 | 15.19 | 17 | 10873 | 4017 | 90613540 |
| Adjacent segment degeneration | 43.49 | 15.19 | 7 | 10883 | 36 | 90617521 |
| Diverticulum intestinal | 42.08 | 15.19 | 21 | 10869 | 9121 | 90608436 |
| Central pain syndrome | 38.31 | 15.19 | 10 | 10880 | 660 | 90616897 |
| Apraxia | 37.56 | 15.19 | 13 | 10877 | 2249 | 90615308 |
| Hyperaesthesia | 36.19 | 15.19 | 20 | 10870 | 10682 | 90606875 |
| Perseveration | 35.67 | 15.19 | 8 | 10882 | 277 | 90617280 |
| Disorientation | 34.53 | 15.19 | 34 | 10856 | 44080 | 90573477 |
| Spinal pain | 33.86 | 15.19 | 22 | 10868 | 15745 | 90601812 |
| Groin pain | 33.73 | 15.19 | 20 | 10870 | 12193 | 90605364 |
| Infusion related reaction | 33.65 | 15.19 | 5 | 10885 | 416775 | 90200782 |
| Junctional ectopic tachycardia | 32.05 | 15.19 | 7 | 10883 | 214 | 90617343 |
| Drug abuse | 31.60 | 15.19 | 44 | 10846 | 82303 | 90535254 |
| Porphyrins urine increased | 31.52 | 15.19 | 5 | 10885 | 23 | 90617534 |
| Chronic gastritis | 31.20 | 15.19 | 13 | 10877 | 3728 | 90613829 |
| Polymyalgia rheumatica | 30.75 | 15.19 | 14 | 10876 | 4963 | 90612594 |
| Porphyrins stool increased | 30.41 | 15.19 | 5 | 10885 | 30 | 90617527 |
| Systemic lupus erythematosus | 30.01 | 15.19 | 4 | 10886 | 361892 | 90255665 |
| Drug reaction with eosinophilia and systemic symptoms | 29.89 | 15.19 | 31 | 10859 | 42727 | 90574830 |
| Reactive gastropathy | 29.07 | 15.19 | 8 | 10882 | 646 | 90616911 |
| Joint contracture | 28.99 | 15.19 | 10 | 10880 | 1712 | 90615845 |
| Withdrawal syndrome | 28.94 | 15.19 | 23 | 10867 | 22501 | 90595056 |
| Iliotibial band syndrome | 28.28 | 15.19 | 7 | 10883 | 373 | 90617184 |
| Foramen magnum stenosis | 27.48 | 15.19 | 6 | 10884 | 183 | 90617374 |
| Intervertebral disc protrusion | 27.14 | 15.19 | 24 | 10866 | 27172 | 90590385 |
| Metastases to lymph nodes | 26.81 | 15.19 | 17 | 10873 | 11672 | 90605885 |
| Meteoropathy | 26.56 | 15.19 | 4 | 10886 | 12 | 90617545 |
| Rotator cuff syndrome | 26.55 | 15.19 | 19 | 10871 | 15900 | 90601657 |
| Synovectomy | 26.52 | 15.19 | 6 | 10884 | 216 | 90617341 |
| Thoracic vertebral fracture | 26.46 | 15.19 | 13 | 10877 | 5461 | 90612096 |
| Wound | 25.97 | 15.19 | 3 | 10887 | 302977 | 90314580 |
| Lumbar vertebral fracture | 25.39 | 15.19 | 14 | 10876 | 7444 | 90610113 |
| Abdominal discomfort | 25.15 | 15.19 | 13 | 10877 | 477315 | 90140242 |
| Hip deformity | 25.07 | 15.19 | 6 | 10884 | 277 | 90617280 |
| Ischaemic stroke | 25.04 | 15.19 | 21 | 10869 | 22145 | 90595412 |
| Product dose omission issue | 24.72 | 15.19 | 3 | 10887 | 291684 | 90325873 |
| Osteoarthritis | 24.68 | 15.19 | 65 | 10825 | 195665 | 90421892 |
| Porphyria non-acute | 24.67 | 15.19 | 6 | 10884 | 297 | 90617260 |
| Femur fracture | 24.58 | 15.19 | 29 | 10861 | 46053 | 90571504 |
| Diaphragmatic hernia | 24.37 | 15.19 | 7 | 10883 | 660 | 90616897 |
| Thyroid hormones decreased | 24.15 | 15.19 | 7 | 10883 | 682 | 90616875 |
| Chondromalacia | 24.12 | 15.19 | 6 | 10884 | 326 | 90617231 |
| Unwanted pregnancy | 24.10 | 15.19 | 5 | 10885 | 119 | 90617438 |
| Pustule | 23.98 | 15.19 | 10 | 10880 | 2873 | 90614684 |
| Nail avulsion | 23.77 | 15.19 | 6 | 10884 | 346 | 90617211 |
| Cyst | 23.64 | 15.19 | 18 | 10872 | 16543 | 90601014 |
| Ovulation disorder | 23.55 | 15.19 | 4 | 10886 | 30 | 90617527 |
| Toxic epidermal necrolysis | 23.48 | 15.19 | 24 | 10866 | 32504 | 90585053 |
| Osteoporosis postmenopausal | 23.43 | 15.19 | 6 | 10884 | 367 | 90617190 |
| Vertebral lesion | 23.36 | 15.19 | 7 | 10883 | 765 | 90616792 |
| Gastrointestinal infection | 22.78 | 15.19 | 15 | 10875 | 10975 | 90606582 |
| Ankylosing spondylitis | 22.65 | 15.19 | 16 | 10874 | 13117 | 90604440 |
| Pericarditis | 22.36 | 15.19 | 3 | 10887 | 270148 | 90347409 |
| Hypotonia | 22.25 | 15.19 | 15 | 10875 | 11411 | 90606146 |
| Nasal turbinate hypertrophy | 22.14 | 15.19 | 7 | 10883 | 914 | 90616643 |
| Peripheral nerve lesion | 21.96 | 15.19 | 6 | 10884 | 471 | 90617086 |
| Drug eruption | 21.79 | 15.19 | 24 | 10866 | 35383 | 90582174 |
| Diverticulitis | 21.76 | 15.19 | 27 | 10863 | 45160 | 90572397 |
| Acute kidney injury | 21.72 | 15.19 | 86 | 10804 | 320301 | 90297256 |
| Pericardial effusion malignant | 21.67 | 15.19 | 5 | 10885 | 197 | 90617360 |
| Serum ferritin decreased | 21.52 | 15.19 | 9 | 10881 | 2605 | 90614952 |
| Meniscus injury | 21.47 | 15.19 | 13 | 10877 | 8224 | 90609333 |
| Postoperative delirium | 21.33 | 15.19 | 5 | 10885 | 211 | 90617346 |
| Sopor | 21.18 | 15.19 | 20 | 10870 | 24624 | 90592933 |
| Spinal fracture | 21.12 | 15.19 | 19 | 10871 | 21997 | 90595560 |
| Angioedema | 21.01 | 15.19 | 32 | 10858 | 64844 | 90552713 |
| Skin hyperpigmentation | 20.98 | 15.19 | 12 | 10878 | 6839 | 90610718 |
| Ovarian cyst | 20.80 | 15.19 | 17 | 10873 | 17301 | 90600256 |
| Radial nerve palsy | 20.50 | 15.19 | 6 | 10884 | 605 | 90616952 |
| Hyperlipidaemia | 20.47 | 15.19 | 19 | 10871 | 22897 | 90594660 |
| Hallucination, visual | 20.34 | 15.19 | 19 | 10871 | 23073 | 90594484 |
| Aortic valve stenosis | 20.28 | 15.19 | 10 | 10880 | 4230 | 90613327 |
| Paranasal sinus inflammation | 20.23 | 15.19 | 6 | 10884 | 633 | 90616924 |
| Interspinous osteoarthritis | 20.13 | 15.19 | 4 | 10886 | 76 | 90617481 |
| Alopecia | 20.05 | 15.19 | 18 | 10872 | 495053 | 90122504 |
| Synovial disorder | 19.99 | 15.19 | 9 | 10881 | 3109 | 90614448 |
| Uveitis | 19.92 | 15.19 | 16 | 10874 | 15887 | 90601670 |
| Sinobronchitis | 19.68 | 15.19 | 6 | 10884 | 695 | 90616862 |
| Tumour invasion | 19.57 | 15.19 | 5 | 10885 | 303 | 90617254 |
| Supraventricular tachycardia | 19.54 | 15.19 | 16 | 10874 | 16320 | 90601237 |
| Lactic acidosis | 19.41 | 15.19 | 27 | 10863 | 50436 | 90567121 |
| Excessive eye blinking | 19.41 | 15.19 | 7 | 10883 | 1365 | 90616192 |
| Dysplasia | 19.30 | 15.19 | 7 | 10883 | 1387 | 90616170 |
| Dyschromatopsia | 19.23 | 15.19 | 6 | 10884 | 751 | 90616806 |
| Sensation of foreign body | 19.09 | 15.19 | 11 | 10879 | 6355 | 90611202 |
| Vocal cord leukoplakia | 19.06 | 15.19 | 3 | 10887 | 13 | 90617544 |
| Patellofemoral pain syndrome | 19.05 | 15.19 | 6 | 10884 | 774 | 90616783 |
| Pyelocaliectasis | 18.98 | 15.19 | 6 | 10884 | 783 | 90616774 |
| Mesenteritis | 18.98 | 15.19 | 5 | 10885 | 342 | 90617215 |
| Subileus | 18.65 | 15.19 | 9 | 10881 | 3635 | 90613922 |
| Hyperreflexia | 18.64 | 15.19 | 11 | 10879 | 6646 | 90610911 |
| Dysaesthesia | 18.26 | 15.19 | 10 | 10880 | 5245 | 90612312 |
| Blood iron decreased | 18.22 | 15.19 | 16 | 10874 | 17943 | 90599614 |
| Sudden death | 18.14 | 15.19 | 13 | 10877 | 10896 | 90606661 |
| Carotid artery stenosis | 18.12 | 15.19 | 10 | 10880 | 5324 | 90612233 |
| Hepatitis A antibody abnormal | 18.11 | 15.19 | 4 | 10886 | 129 | 90617428 |
| Dermatitis psoriasiform | 18.05 | 15.19 | 8 | 10882 | 2664 | 90614893 |
| Defaecation disorder | 18.02 | 15.19 | 6 | 10884 | 923 | 90616634 |
| Facial paresis | 17.93 | 15.19 | 9 | 10881 | 3954 | 90613603 |
| Disturbance in attention | 17.81 | 15.19 | 25 | 10865 | 47084 | 90570473 |
| Product prescribing error | 17.81 | 15.19 | 20 | 10870 | 30125 | 90587432 |
| Allodynia | 17.45 | 15.19 | 6 | 10884 | 1018 | 90616539 |
| Hepatic enzyme increased | 17.31 | 15.19 | 11 | 10879 | 360725 | 90256832 |
| Nasal septum deviation | 17.04 | 15.19 | 7 | 10883 | 1936 | 90615621 |
| Speech disorder | 16.95 | 15.19 | 24 | 10866 | 45561 | 90571996 |
| Ulnar nerve injury | 16.75 | 15.19 | 4 | 10886 | 183 | 90617374 |
| Osteopenia | 16.66 | 15.19 | 17 | 10873 | 22985 | 90594572 |
| Hemianopia | 16.57 | 15.19 | 7 | 10883 | 2075 | 90615482 |
| Respiratory tract infection | 16.19 | 15.19 | 27 | 10863 | 59051 | 90558506 |
| Tendon disorder | 16.00 | 15.19 | 10 | 10880 | 6690 | 90610867 |
| Epidermal necrosis | 15.73 | 15.19 | 7 | 10883 | 2354 | 90615203 |
| Infected fistula | 15.60 | 15.19 | 4 | 10886 | 246 | 90617311 |
| Collagen disorder | 15.46 | 15.19 | 4 | 10886 | 255 | 90617302 |
| Acquired porphyria | 15.45 | 15.19 | 5 | 10885 | 704 | 90616853 |
| Bone marrow oedema | 15.36 | 15.19 | 6 | 10884 | 1457 | 90616100 |
| Substance abuse | 15.31 | 15.19 | 9 | 10881 | 5397 | 90612160 |
| Joint swelling | 15.31 | 15.19 | 23 | 10867 | 503277 | 90114280 |
| Eosinophilia | 15.29 | 15.19 | 18 | 10872 | 28515 | 90589042 |
| Hiatus hernia | 15.28 | 15.19 | 17 | 10873 | 25344 | 90592213 |
| Anaemia | 15.23 | 15.19 | 83 | 10807 | 352719 | 90264838 |
| Pneumonia haemophilus | 15.20 | 15.19 | 6 | 10884 | 1497 | 90616060 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Regurgitation | 66.50 | 17.29 | 21 | 7257 | 1919 | 42612138 |
| General physical health deterioration | 62.95 | 17.29 | 101 | 7177 | 151145 | 42462912 |
| Spinal pain | 49.95 | 17.29 | 24 | 7254 | 6758 | 42607299 |
| Systemic infection | 49.52 | 17.29 | 22 | 7256 | 5183 | 42608874 |
| Hepatitis E antibody positive | 49.40 | 17.29 | 11 | 7267 | 256 | 42613801 |
| Pregnancy of partner | 49.10 | 17.29 | 12 | 7266 | 423 | 42613634 |
| Body mass index abnormal | 48.17 | 17.29 | 10 | 7268 | 165 | 42613892 |
| Hepatitis E virus test positive | 47.83 | 17.29 | 11 | 7267 | 297 | 42613760 |
| Oropharyngeal discomfort | 47.54 | 17.29 | 20 | 7258 | 4129 | 42609928 |
| Vitamin B12 deficiency | 47.45 | 17.29 | 21 | 7257 | 4901 | 42609156 |
| Death | 44.08 | 17.29 | 13 | 7265 | 471172 | 42142885 |
| Bursitis | 42.68 | 17.29 | 21 | 7257 | 6223 | 42607834 |
| Oral mucosa erosion | 42.45 | 17.29 | 13 | 7265 | 1073 | 42612984 |
| Eructation | 42.18 | 17.29 | 20 | 7258 | 5466 | 42608591 |
| Mucosal necrosis | 41.54 | 17.29 | 8 | 7270 | 88 | 42613969 |
| Antiphospholipid antibodies positive | 39.84 | 17.29 | 10 | 7268 | 394 | 42613663 |
| Ligament calcification | 39.54 | 17.29 | 9 | 7269 | 232 | 42613825 |
| Axial spondyloarthritis | 36.87 | 17.29 | 10 | 7268 | 535 | 42613522 |
| Product prescribing error | 35.58 | 17.29 | 32 | 7246 | 26080 | 42587977 |
| Neck pain | 35.52 | 17.29 | 34 | 7244 | 29980 | 42584077 |
| Suspected transmission of an infectious agent via product | 35.51 | 17.29 | 11 | 7267 | 943 | 42613114 |
| Coating in mouth | 35.13 | 17.29 | 7 | 7271 | 93 | 42613964 |
| Lip erosion | 35.13 | 17.29 | 10 | 7268 | 640 | 42613417 |
| Ankylosing spondylitis | 34.63 | 17.29 | 19 | 7259 | 7037 | 42607020 |
| Respiratory fatigue | 33.86 | 17.29 | 7 | 7271 | 113 | 42613944 |
| Hand fracture | 33.27 | 17.29 | 14 | 7264 | 2892 | 42611165 |
| Electric shock sensation | 33.23 | 17.29 | 9 | 7269 | 479 | 42613578 |
| Chronic idiopathic pain syndrome | 32.21 | 17.29 | 7 | 7271 | 145 | 42613912 |
| Sacroiliitis | 31.17 | 17.29 | 12 | 7266 | 1970 | 42612087 |
| Prostatic pain | 31.04 | 17.29 | 8 | 7270 | 351 | 42613706 |
| Craniocerebral injury | 29.54 | 17.29 | 14 | 7264 | 3820 | 42610237 |
| Palmoplantar pustulosis | 28.49 | 17.29 | 8 | 7270 | 487 | 42613570 |
| Adjustment disorder with disturbance of conduct | 27.95 | 17.29 | 6 | 7272 | 117 | 42613940 |
| Helicobacter gastritis | 27.89 | 17.29 | 10 | 7268 | 1347 | 42612710 |
| Osteoarthritis | 27.65 | 17.29 | 27 | 7251 | 24378 | 42589679 |
| Fluid intake reduced | 25.90 | 17.29 | 13 | 7265 | 4019 | 42610038 |
| Otitis media | 24.02 | 17.29 | 12 | 7266 | 3671 | 42610386 |
| Costovertebral angle tenderness | 24.00 | 17.29 | 5 | 7273 | 84 | 42613973 |
| Haemophilic arthropathy | 23.53 | 17.29 | 6 | 7272 | 252 | 42613805 |
| Iridocyclitis | 23.15 | 17.29 | 10 | 7268 | 2201 | 42611856 |
| Paternal exposure during pregnancy | 22.55 | 17.29 | 5 | 7273 | 114 | 42613943 |
| Poor peripheral circulation | 22.35 | 17.29 | 9 | 7269 | 1662 | 42612395 |
| Peritoneal adhesions | 22.31 | 17.29 | 5 | 7273 | 120 | 42613937 |
| Depersonalisation/derealisation disorder | 21.89 | 17.29 | 7 | 7271 | 665 | 42613392 |
| Gastrointestinal inflammation | 21.53 | 17.29 | 12 | 7266 | 4580 | 42609477 |
| Formication | 20.62 | 17.29 | 9 | 7269 | 2032 | 42612025 |
| Psoriatic arthropathy | 20.05 | 17.29 | 23 | 7255 | 24944 | 42589113 |
| Pharyngeal exudate | 19.73 | 17.29 | 3 | 7275 | 6 | 42614051 |
| Pharyngeal lesion | 19.73 | 17.29 | 3 | 7275 | 6 | 42614051 |
| Febrile neutropenia | 19.48 | 17.29 | 4 | 7274 | 185699 | 42428358 |
| pH body fluid increased | 19.32 | 17.29 | 4 | 7274 | 65 | 42613992 |
| Immune-mediated adverse reaction | 19.25 | 17.29 | 7 | 7271 | 981 | 42613076 |
| Oral pruritus | 19.21 | 17.29 | 6 | 7272 | 528 | 42613529 |
| Anaemia of malignant disease | 19.14 | 17.29 | 6 | 7272 | 535 | 42613522 |
| Prerenal failure | 19.10 | 17.29 | 9 | 7269 | 2424 | 42611633 |
| Personality change | 19.09 | 17.29 | 12 | 7266 | 5707 | 42608350 |
| Cardiac valve sclerosis | 19.04 | 17.29 | 4 | 7274 | 70 | 42613987 |
| Sialadenosis | 18.87 | 17.29 | 3 | 7275 | 9 | 42614048 |
| Open angle glaucoma | 18.41 | 17.29 | 5 | 7273 | 269 | 42613788 |
| Polyneuropathy | 18.13 | 17.29 | 19 | 7259 | 18642 | 42595415 |
| Impaired healing | 17.72 | 17.29 | 18 | 7260 | 17035 | 42597022 |
| Drug interaction | 17.63 | 17.29 | 91 | 7187 | 266908 | 42347149 |
| Aortic valve incompetence | 17.61 | 17.29 | 12 | 7266 | 6536 | 42607521 |
| Intensive care unit acquired weakness | 17.50 | 17.29 | 7 | 7271 | 1271 | 42612786 |
| Endocarditis | 17.45 | 17.29 | 13 | 7265 | 8139 | 42605918 |
| Condition aggravated | 17.30 | 17.29 | 89 | 7189 | 260665 | 42353392 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug interaction | 81.22 | 14.19 | 203 | 15566 | 499980 | 110073550 |
| Regurgitation | 69.57 | 14.19 | 24 | 15745 | 3461 | 110570069 |
| Product prescribing error | 57.34 | 14.19 | 52 | 15717 | 51279 | 110522251 |
| Spinal pain | 55.56 | 14.19 | 34 | 15735 | 18481 | 110555049 |
| Fixed eruption | 54.16 | 14.19 | 21 | 15748 | 4211 | 110569319 |
| Axial spondyloarthritis | 52.17 | 14.19 | 14 | 15755 | 864 | 110572666 |
| Hepatitis E antibody positive | 51.29 | 14.19 | 11 | 15758 | 258 | 110573272 |
| Labelled drug-drug interaction medication error | 50.11 | 14.19 | 38 | 15731 | 29264 | 110544266 |
| Thrombocytosis | 49.86 | 14.19 | 26 | 15743 | 10418 | 110563112 |
| Hepatitis E virus test positive | 49.80 | 14.19 | 11 | 15758 | 297 | 110573233 |
| Oral mucosa erosion | 49.42 | 14.19 | 17 | 15752 | 2431 | 110571099 |
| Inflammatory marker increased | 47.11 | 14.19 | 28 | 15741 | 14441 | 110559089 |
| Lip erosion | 45.75 | 14.19 | 15 | 15754 | 1851 | 110571679 |
| Ankylosing spondylitis | 45.14 | 14.19 | 28 | 15741 | 15584 | 110557946 |
| Pregnancy of partner | 44.20 | 14.19 | 10 | 15759 | 302 | 110573228 |
| Lung adenocarcinoma stage IV | 43.05 | 14.19 | 11 | 15758 | 560 | 110572970 |
| Ligament calcification | 41.11 | 14.19 | 9 | 15760 | 233 | 110573297 |
| Perseveration | 41.08 | 14.19 | 10 | 15759 | 417 | 110573113 |
| General physical health deterioration | 40.53 | 14.19 | 143 | 15626 | 425152 | 110148378 |
| Systemic infection | 40.01 | 14.19 | 22 | 15747 | 9797 | 110563733 |
| Thoracic vertebral fracture | 38.90 | 14.19 | 19 | 15750 | 6636 | 110566894 |
| Toxic epidermal necrolysis | 38.65 | 14.19 | 44 | 15725 | 56683 | 110516847 |
| Polymyalgia rheumatica | 36.48 | 14.19 | 18 | 15751 | 6424 | 110567106 |
| Mucosal necrosis | 36.47 | 14.19 | 8 | 15761 | 209 | 110573321 |
| Chronic gastritis | 36.35 | 14.19 | 17 | 15752 | 5394 | 110568136 |
| Product dose omission issue | 34.76 | 14.19 | 3 | 15766 | 321779 | 110251751 |
| Central pain syndrome | 34.61 | 14.19 | 10 | 15759 | 810 | 110572720 |
| Vitamin B12 deficiency | 34.15 | 14.19 | 20 | 15749 | 10035 | 110563495 |
| Skin hyperpigmentation | 34.11 | 14.19 | 19 | 15750 | 8677 | 110564853 |
| Coating in mouth | 34.00 | 14.19 | 8 | 15761 | 288 | 110573242 |
| Prostatic pain | 33.92 | 14.19 | 8 | 15761 | 291 | 110573239 |
| Death | 33.79 | 14.19 | 30 | 15739 | 698839 | 109874691 |
| Oropharyngeal discomfort | 33.66 | 14.19 | 20 | 15749 | 10307 | 110563223 |
| Body mass index abnormal | 33.39 | 14.19 | 10 | 15759 | 918 | 110572612 |
| Suspected transmission of an infectious agent via product | 33.31 | 14.19 | 11 | 15758 | 1389 | 110572141 |
| Infusion related reaction | 33.08 | 14.19 | 7 | 15762 | 381155 | 110192375 |
| Femur fracture | 32.88 | 14.19 | 36 | 15733 | 44433 | 110529097 |
| Sacroiliitis | 31.48 | 14.19 | 15 | 15754 | 4963 | 110568567 |
| Immune-mediated adverse reaction | 31.21 | 14.19 | 11 | 15758 | 1689 | 110571841 |
| Intervertebral disc protrusion | 30.81 | 14.19 | 28 | 15741 | 27670 | 110545860 |
| Lumbar vertebral fracture | 30.59 | 14.19 | 18 | 15751 | 9113 | 110564417 |
| Chronic idiopathic pain syndrome | 30.52 | 14.19 | 7 | 15762 | 225 | 110573305 |
| Spinal osteoarthritis | 29.80 | 14.19 | 24 | 15745 | 20159 | 110553371 |
| Porphyrins urine increased | 29.70 | 14.19 | 5 | 15764 | 29 | 110573501 |
| Synovectomy | 29.54 | 14.19 | 7 | 15762 | 260 | 110573270 |
| Antiphospholipid antibodies positive | 29.07 | 14.19 | 9 | 15760 | 924 | 110572606 |
| Respiratory fatigue | 28.77 | 14.19 | 7 | 15762 | 291 | 110573239 |
| Eructation | 28.02 | 14.19 | 20 | 15749 | 14037 | 110559493 |
| Porphyrins stool increased | 27.87 | 14.19 | 5 | 15764 | 44 | 110573486 |
| Withdrawal syndrome | 27.84 | 14.19 | 28 | 15741 | 31352 | 110542178 |
| Poor peripheral circulation | 27.62 | 14.19 | 13 | 15756 | 4184 | 110569346 |
| Iridocyclitis | 27.36 | 14.19 | 14 | 15755 | 5394 | 110568136 |
| Hyperaesthesia | 27.19 | 14.19 | 20 | 15749 | 14707 | 110558823 |
| Anaemia | 26.91 | 14.19 | 151 | 15618 | 546935 | 110026595 |
| Helicobacter gastritis | 26.60 | 14.19 | 11 | 15758 | 2605 | 110570925 |
| Apraxia | 26.53 | 14.19 | 12 | 15757 | 3528 | 110570002 |
| Craniocerebral injury | 26.14 | 14.19 | 14 | 15755 | 5920 | 110567610 |
| Meteoropathy | 25.88 | 14.19 | 4 | 15765 | 12 | 110573518 |
| Systemic lupus erythematosus | 25.83 | 14.19 | 3 | 15766 | 254335 | 110319195 |
| Haemophilic arthropathy | 25.64 | 14.19 | 6 | 15763 | 211 | 110573319 |
| Palmoplantar pustulosis | 24.47 | 14.19 | 8 | 15761 | 978 | 110572552 |
| Drug eruption | 24.38 | 14.19 | 34 | 15735 | 53625 | 110519905 |
| Tongue oedema | 24.36 | 14.19 | 15 | 15754 | 8241 | 110565289 |
| Sopor | 24.31 | 14.19 | 28 | 15741 | 36518 | 110537012 |
| Disorientation | 23.88 | 14.19 | 39 | 15730 | 70632 | 110502898 |
| Diaphragmatic hernia | 23.75 | 14.19 | 7 | 15762 | 608 | 110572922 |
| Joint contracture | 23.74 | 14.19 | 10 | 15759 | 2481 | 110571049 |
| Spinal fracture | 23.47 | 14.19 | 22 | 15747 | 22611 | 110550919 |
| Dermatitis psoriasiform | 23.10 | 14.19 | 11 | 15758 | 3633 | 110569897 |
| Thyroid hormones decreased | 22.90 | 14.19 | 7 | 15762 | 688 | 110572842 |
| Electric shock sensation | 22.60 | 14.19 | 9 | 15760 | 1935 | 110571595 |
| Fluid intake reduced | 21.40 | 14.19 | 13 | 15756 | 6973 | 110566557 |
| Pericarditis | 21.24 | 14.19 | 3 | 15766 | 219111 | 110354419 |
| Wound | 20.96 | 14.19 | 4 | 15765 | 234433 | 110339097 |
| Gamma-glutamyltransferase increased | 20.94 | 14.19 | 34 | 15735 | 61275 | 110512255 |
| Pustule | 20.47 | 14.19 | 10 | 15759 | 3494 | 110570036 |
| Abdominal discomfort | 20.12 | 14.19 | 16 | 15753 | 393842 | 110179688 |
| Ischaemic stroke | 20.04 | 14.19 | 27 | 15742 | 41236 | 110532294 |
| Dysuria | 20.03 | 14.19 | 33 | 15736 | 60198 | 110513332 |
| Completed suicide | 19.92 | 14.19 | 5 | 15764 | 242376 | 110331154 |
| Neck pain | 19.92 | 14.19 | 50 | 15719 | 123080 | 110450450 |
| Open angle glaucoma | 19.85 | 14.19 | 6 | 15763 | 568 | 110572962 |
| Costovertebral angle tenderness | 19.71 | 14.19 | 5 | 15764 | 247 | 110573283 |
| Hand fracture | 19.60 | 14.19 | 13 | 15756 | 8109 | 110565421 |
| Maternal exposure during pregnancy | 19.57 | 14.19 | 6 | 15763 | 254877 | 110318653 |
| pH body fluid increased | 19.55 | 14.19 | 4 | 15765 | 74 | 110573456 |
| Interspinous osteoarthritis | 19.45 | 14.19 | 4 | 15765 | 76 | 110573454 |
| Electrolyte imbalance | 19.17 | 14.19 | 25 | 15744 | 37003 | 110536527 |
| Synovial disorder | 18.83 | 14.19 | 9 | 15760 | 2998 | 110570532 |
| Pharyngeal exudate | 18.74 | 14.19 | 3 | 15766 | 12 | 110573518 |
| Intentional product use issue | 18.74 | 14.19 | 6 | 15763 | 247900 | 110325630 |
| Off label use | 18.40 | 14.19 | 132 | 15637 | 1500053 | 109073477 |
| Porphyria non-acute | 18.22 | 14.19 | 6 | 15763 | 751 | 110572779 |
| Cardiac valve sclerosis | 18.15 | 14.19 | 4 | 15765 | 107 | 110573423 |
| Skin lesion | 18.14 | 14.19 | 29 | 15740 | 51602 | 110521928 |
| Otitis media | 18.12 | 14.19 | 12 | 15757 | 7464 | 110566066 |
| Peritoneal adhesions | 18.07 | 14.19 | 5 | 15764 | 346 | 110573184 |
| Oral pruritus | 17.98 | 14.19 | 9 | 15760 | 3311 | 110570219 |
| Face oedema | 17.95 | 14.19 | 23 | 15746 | 33446 | 110540084 |
| Hyperreflexia | 17.78 | 14.19 | 13 | 15756 | 9472 | 110564058 |
| Hepatitis A antibody abnormal | 17.43 | 14.19 | 4 | 15765 | 129 | 110573401 |
| Aortic valve stenosis | 17.38 | 14.19 | 11 | 15758 | 6339 | 110567191 |
| Toothache | 17.28 | 14.19 | 19 | 15750 | 23556 | 110549974 |
| Gastrointestinal submucosal tumour | 17.28 | 14.19 | 4 | 15765 | 134 | 110573396 |
| Prostate cancer metastatic | 17.23 | 14.19 | 10 | 15759 | 4933 | 110568597 |
| Drug abuse | 17.16 | 14.19 | 60 | 15709 | 177351 | 110396179 |
| Angioedema | 16.99 | 14.19 | 41 | 15728 | 98459 | 110475071 |
| Spondylolisthesis | 16.84 | 14.19 | 9 | 15760 | 3789 | 110569741 |
| Anaemia of malignant disease | 16.60 | 14.19 | 6 | 15763 | 990 | 110572540 |
| Pharyngeal lesion | 16.57 | 14.19 | 3 | 15766 | 28 | 110573502 |
| Hemianopia | 16.20 | 14.19 | 8 | 15761 | 2860 | 110570670 |
| Excessive eye blinking | 16.14 | 14.19 | 7 | 15762 | 1863 | 110571667 |
| Epidermal necrosis | 15.73 | 14.19 | 8 | 15761 | 3042 | 110570488 |
| Lip oedema | 15.58 | 14.19 | 11 | 15758 | 7589 | 110565941 |
| Gastrointestinal inflammation | 15.57 | 14.19 | 12 | 15757 | 9457 | 110564073 |
| Pneumonitis | 15.57 | 14.19 | 34 | 15735 | 76497 | 110497033 |
| Urethral stenosis | 15.50 | 14.19 | 6 | 15763 | 1198 | 110572332 |
| Prerenal failure | 15.49 | 14.19 | 9 | 15760 | 4450 | 110569080 |
| Lactic acidosis | 15.34 | 14.19 | 38 | 15731 | 92773 | 110480757 |
| Arthralgia | 15.25 | 14.19 | 174 | 15595 | 779458 | 109794072 |
| Depersonalisation/derealisation disorder | 15.11 | 14.19 | 7 | 15762 | 2174 | 110571356 |
| Dyschromatopsia | 15.08 | 14.19 | 6 | 15763 | 1288 | 110572242 |
| Disease progression | 15.06 | 14.19 | 8 | 15761 | 244026 | 110329504 |
| Weight increased | 14.89 | 14.19 | 23 | 15746 | 419621 | 110153909 |
| Subileus | 14.80 | 14.19 | 10 | 15759 | 6427 | 110567103 |
| Intensive care unit acquired weakness | 14.59 | 14.19 | 7 | 15762 | 2352 | 110571178 |
| Mucosal ulceration | 14.53 | 14.19 | 7 | 15762 | 2372 | 110571158 |
| Psychotic behaviour | 14.52 | 14.19 | 6 | 15763 | 1419 | 110572111 |
| Acquired porphyria | 14.50 | 14.19 | 5 | 15764 | 720 | 110572810 |
| Parapsoriasis | 14.47 | 14.19 | 4 | 15765 | 276 | 110573254 |
| Delayed sleep phase | 14.40 | 14.19 | 3 | 15766 | 61 | 110573469 |
| Ulnar nerve injury | 14.25 | 14.19 | 4 | 15765 | 292 | 110573238 |
| Gastrointestinal ulcer perforation | 14.21 | 14.19 | 3 | 15766 | 65 | 110573465 |
| Tuberculosis | 14.21 | 14.19 | 15 | 15754 | 17759 | 110555771 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | M01AH05 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Coxibs |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D016861 | Cyclooxygenase Inhibitors |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D018689 | Sensory System Agents |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| MeSH PA | D052246 | Cyclooxygenase 2 Inhibitors |
| CHEBI has role | CHEBI:33231 | antitubercular agent |
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory drug |
| CHEBI has role | CHEBI:35480 | analgesic |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35842 | antirheumatic drug |
| CHEBI has role | CHEBI:50629 | cyclooxygenase 2 inhibitor |
| CHEBI has role | CHEBI:64946 | anti-HIV agent |
| CHEBI has role | CHEBI:67079 | anti-inflammatory agent |
| CHEBI has role | CHEBI:73336 | vulnerary |
Related Drugs by ATC class:
M01AH Coxibs 6 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.6 | Basic |
| pKa2 | 1.75 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 6.10 | WOMBAT-PK | IUPHAR | |||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 4.92 | CHEMBL | |||||
| Prostaglandin E2 receptor EP2 subtype | GPCR | Ki | 7.10 | PDSP | |||||
| Mitogen-activated protein kinase 14 | Kinase | IC50 | 6.28 | CHEMBL | |||||
| Prostaglandin G/H synthase 2 | Enzyme | IC50 | 6.64 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D03710 | KEGG_DRUG |
| C0972314 | UMLSCUI |
| CHEBI:6339 | CHEBI |
| CHEMBL416146 | ChEMBL_ID |
| DB01628 | DRUGBANK_ID |
| D000077613 | MESH_DESCRIPTOR_UI |
| 123619 | PUBCHEM_CID |
| 2896 | IUPHAR_LIGAND_ID |
| 8082 | INN_ID |
| WRX4NFY03R | UNII |
| 307296 | RXNORM |
| 009633 | NDDF |
| 395292007 | SNOMEDCT_US |
| 409134009 | SNOMEDCT_US |
| 5CH | PDB_CHEM_ID |
Pharmaceutical products:
None