camphor Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	470	76-22-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: camphor alphanon borneo camphor DL-Camphor root bark oil 2-Bornanone 2-Camphanone camphor (synthetic) camphor (natural) camphor, (synthetic) camphor, (+/-)- camphora	A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent. Molecular weight: 152.24 Formula: C10H16O CLOGP: 2.18 LIPINSKI: 0 HAC: 1 HDO: 0 TPSA: 17.07 ALOGS: -2.24 ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

camphor
alphanon
borneo camphor
DL-Camphor
root bark oil
2-Bornanone
2-Camphanone
camphor (synthetic)
camphor (natural)
camphor, (synthetic)
camphor, (+/-)-
camphora

A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.

Molecular weight: 152.24
Formula: C10H16O
CLOGP: 2.18
LIPINSKI: 0
HAC: 1
HDO: 0
TPSA: 17.07
ALOGS: -2.24
ROTB: 0

Drug dosage:

Dose	Unit	Route
0.15	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Methaemoglobinaemia	217.35	18.25	44	2705	2228	53344089
Cyanosis	31.72	18.25	16	2733	16623	53329694
Drug hypersensitivity	30.08	18.25	51	2698	265191	53081126
Nail bed tenderness	24.07	18.25	5	2744	286	53346031
Vulvovaginal swelling	21.57	18.25	5	2744	475	53345842
Fallopian tube cyst	21.06	18.25	4	2745	144	53346173

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Methaemoglobinaemia	108.44	21.61	25	1353	2851	32509297
Erythema multiforme	23.09	21.61	10	1368	8982	32503166

Pharmacologic Action:

Source	Code	Description
ATC	C01EB02	CARDIOVASCULAR SYSTEM CARDIAC THERAPY OTHER CARDIAC PREPARATIONS Other cardiac preparations
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
CHEBI has role	CHEBI:25212	metabolites
CHEBI has role	CHEBI:27311	ethereal oil components
CHEBI has role	CHEBI:76924	plant metabolites

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Backache	indication	161891005
Sprains and Strains	indication
Arthritic Pain	indication
Gastritis	contraindication	4556007	DOID:4029
Infection of skin AND/OR subcutaneous tissue	contraindication	19824006
Gastrointestinal ulcer	contraindication	40845000
Body fluid retention	contraindication	43498006
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Vitamin K deficiency	contraindication	52675005	DOID:11249
Nasal polyp	contraindication	52756005
Hepatic failure	contraindication	59927004
Blood coagulation disorder	contraindication	64779008	DOID:1247
Diabetes mellitus	contraindication	73211009	DOID:9351
Factor II deficiency	contraindication	73975000
Gastrointestinal hemorrhage	contraindication	74474003
Thrombotic thrombocytopenic purpura	contraindication	78129009	DOID:10772
Kidney disease	contraindication	90708001	DOID:557
Thyrotoxicosis	contraindication	90739004	DOID:7997
Hemophilia	contraindication	90935002
Disorder of skin	contraindication	95320005	DOID:37
Anemia due to enzyme deficiency	contraindication	111577008
Gastroesophageal reflux disease	contraindication	235595009	DOID:8534
Disease of liver	contraindication	235856003	DOID:409
Condyloma acuminatum	contraindication	240542006	DOID:11168
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Skin irritation	contraindication	367466007
Cardiovascular event risk	contraindication	395112001
Peripheral vascular disease	contraindication	400047006
Breastfeeding (mother)	contraindication	413712001
Blister	contraindication	417237009
Denuded skin	contraindication	418242004
Inflammatory dermatosis	contraindication	703938007

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Acetylcholinesterase	Enzyme		ACES_ELEEL		Ki	4.30		CHEMBL
Transient receptor potential cation channel subfamily A member 1	Ion channel		TRPA1_MOUSE	GATING INHIBITOR	IC50	4.20		IUPHAR

External reference:

ID	Source
4017533	VUID
N0000145916	NUI
D00098	KEGG_DRUG
464-49-3	SECONDARY_CAS_RN
C0006809	UMLSCUI
CHEBI:36773	CHEBI
CAM	PDB_CHEM_ID
CHEMBL504760	ChEMBL_ID
DB01744	DRUGBANK_ID
D002164	MESH_DESCRIPTOR_UI
2537	PUBCHEM_CID
2422	IUPHAR_LIGAND_ID
C436264	MESH_SUPPLEMENTAL_RECORD_UI
5TJD82A1ET	UNII
DB11288	DRUGBANK_ID
DB14156	DRUGBANK_ID
1298738	RXNORM
4343	MMSL
6005	MMSL
001385	NDDF
001993	NDDF
005178	NDDF
006104	NDDF
111136003	SNOMEDCT_US
412108007	SNOMEDCT_US
46137002	SNOMEDCT_US
4017533	VANDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Major Camphor and Phenol	HUMAN OTC DRUG LABEL	2	00904-7851	LIQUID	10.80 g	TOPICAL	OTC monograph final	12 sections
AleveX	HUMAN OTC DRUG LABEL	2	0280-0049	SPRAY	5.50 mg	TOPICAL	OTC monograph not final	15 sections
AleveX	HUMAN OTC DRUG LABEL	2	0280-0050	LOTION	5.50 mg	TOPICAL	OTC monograph not final	15 sections
AleveX	HUMAN OTC DRUG LABEL	2	0280-0063	LOTION	5.50 mg	TOPICAL	OTC monograph not final	14 sections
Sarna	HUMAN OTC DRUG LABEL	2	0316-0229	LOTION	5 mg	TOPICAL	OTC monograph not final	13 sections
Vaporizing	HUMAN OTC DRUG LABEL	1	0363-0055	INHALANT	62 mg	RESPIRATORY (INHALATION)	OTC monograph final	15 sections
WALGREENS MEDICATED PAIN RELIEVING	HUMAN OTC DRUG LABEL	3	0363-0149	PATCH	7.10 mg	TOPICAL	OTC monograph not final	14 sections
Walgreens Cold Sore Treatment	HUMAN OTC DRUG LABEL	2	0363-0407	CREAM	30 mg	TOPICAL	OTC monograph not final	10 sections
Walgreens Cold Sore Treatment	HUMAN OTC DRUG LABEL	2	0363-0407	CREAM	30 mg	TOPICAL	OTC monograph not final	10 sections
Pain Relief Patches	HUMAN OTC DRUG LABEL	3	0363-0907	PATCH	3.10 g	TOPICAL	OTC monograph not final	11 sections
Walgreens Chest Rub	HUMAN OTC DRUG LABEL	3	0363-1001	OINTMENT	48 mg	TOPICAL	OTC monograph final	12 sections
Walgreens Pain Relieving Analgesic	HUMAN OTC DRUG LABEL	3	0363-1199	CREAM	40 mg	TOPICAL	OTC MONOGRAPH NOT FINAL	15 sections
No Touch Application Chest RubWell at Walgreens	HUMAN OTC DRUG LABEL	3	0363-3267	STICK	4.80 g	TOPICAL	OTC monograph final	7 sections
Walgreen Anti Itch	HUMAN OTC DRUG LABEL	2	0363-4262	LOTION	0.50 g	TOPICAL	OTC monograph not final	12 sections
Medicated Lip Balm	HUMAN OTC DRUG LABEL	3	0363-6040	SALVE	1.70 mg	TOPICAL	OTC monograph not final	9 sections
Medicated Lip Balm	HUMAN OTC DRUG LABEL	3	0363-6080	STICK	1.70 mg	TOPICAL	OTC monograph not final	9 sections
Chest Rub	HUMAN OTC DRUG LABEL	3	0363-8480	LOTION	4.80 kg	TOPICAL	OTC monograph final	15 sections
Walgreens Camphor Phenol Gel	HUMAN OTC DRUG LABEL	2	0363-9425	GEL	10.80 mg	TOPICAL	OTC monograph not final	8 sections
Pain Relieving Patches	HUMAN OTC DRUG LABEL	3	0363-9903	PATCH	1.20 1	TOPICAL	OTC monograph not final	12 sections
Large Pain Relieving	HUMAN OTC DRUG LABEL	3	0363-9904	PATCH	3.10 g	TOPICAL	OTC monograph not final	13 sections
HUMCO Camphor Spirit	HUMAN OTC DRUG LABEL	1	0395-0467	LIQUID	100 mg	TOPICAL	OTC monograph not final	13 sections
Camphor Spirit	HUMAN OTC DRUG LABEL	1	0395-9112	LIQUID	100 mg	TOPICAL	OTC monograph not final	12 sections
Rugby Anti-Itch	HUMAN OTC DRUG LABEL	2	0536-1268	LOTION	0.50 g	TOPICAL	OTC monograph not final	11 sections
ANBESOL COLD SORE THERAPY	HUMAN OTC DRUG LABEL	4	0573-0246	OINTMENT	30 mg	TOPICAL	OTC monograph not final	14 sections
CHAPSTICK MEDICATED	HUMAN OTC DRUG LABEL	4	0573-0720	STICK	10 mg	TOPICAL	OTC monograph not final	13 sections
Chest Rub	HUMAN OTC DRUG LABEL	3	0869-0248	CREAM	4.80 kg	TOPICAL	OTC monograph final	16 sections
Camphor	HUMAN OTC DRUG LABEL	1	10095-003	OINTMENT	10 g	TOPICAL	OTC monograph not final	8 sections
Blistex Lip Medex	HUMAN OTC DRUG LABEL	4	10157-8407	PASTE	1 g	TOPICAL	OTC MONOGRAPH NOT FINAL	12 sections
Blistex con Medicacion Crema Labial	HUMAN OTC DRUG LABEL	2	10157-9926	STICK	1 g	TOPICAL	EXPORT ONLY	1 sections
Blistex Medicated	HUMAN OTC DRUG LABEL	4	10157-9951	OINTMENT	0.50 g	TOPICAL	OTC MONOGRAPH NOT FINAL	12 sections