camphor 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
470 76-22-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • camphor
  • alphanon
  • borneo camphor
  • DL-Camphor
  • root bark oil
  • 2-Bornanone
  • 2-Camphanone
  • camphor (synthetic)
  • camphor (natural)
  • camphor, (synthetic)
  • camphor, (+/-)-
  • camphora
A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.
  • Molecular weight: 152.24
  • Formula: C10H16O
  • CLOGP: 2.18
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 17.07
  • ALOGS: -2.24
  • ROTB: 0

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 217.85 18.60 43 2582 2119 56287323
Drug hypersensitivity 39.70 18.60 56 2569 275149 56014293
Nail bed tenderness 34.90 18.60 7 2618 372 56289070
Cyanosis 34.02 18.60 16 2609 15794 56273648
Autonomic neuropathy 27.57 18.60 7 2618 1078 56288364
Anxiety disorder 22.63 18.60 8 2617 3812 56285630
Vulvovaginal swelling 22.29 18.60 5 2620 454 56288988
Skin discolouration 20.19 18.60 15 2610 34341 56255101
Dermatitis atopic 19.72 18.60 9 2616 8290 56281152
Vitamin D deficiency 19.28 18.60 10 2615 12160 56277282
Urticaria thermal 19.00 18.60 4 2621 270 56289172

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 149.45 24.32 32 1151 2974 31693187
Erythema multiforme 28.93 24.32 11 1172 8060 31688101
Pruritus 25.25 24.32 27 1156 125140 31571021

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 343.92 18.12 72 3281 4714 70920377
Cyanosis 39.21 18.12 20 3333 23186 70901905
Nail bed tenderness 34.71 18.12 7 3346 377 70924714
Pruritus 27.11 18.12 54 3299 345506 70579585
Drug hypersensitivity 25.54 18.12 45 3308 262414 70662677
Autonomic neuropathy 24.22 18.12 7 3346 1728 70923363
Vulvovaginal swelling 23.63 18.12 5 3348 341 70924750
Skin discolouration 21.07 18.12 16 3337 37309 70887782
Dermatitis exfoliative 20.49 18.12 10 3343 10541 70914550
Urticaria thermal 18.93 18.12 4 3349 271 70924820
Erythema multiforme 18.87 18.12 11 3342 16553 70908538

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01EB02 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
OTHER CARDIAC PREPARATIONS
Other cardiac preparations
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:27311 essential oil component
CHEBI has role CHEBI:76924 plant metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Backache indication 161891005
Sprains and Strains indication
Arthritic Pain indication
Gastritis contraindication 4556007 DOID:4029
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Disorder of skin contraindication 95320005 DOID:37
Anemia due to enzyme deficiency contraindication 111577008
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Skin irritation contraindication 367466007
Cardiovascular event risk contraindication 395112001
Peripheral vascular disease contraindication 400047006
Breastfeeding (mother) contraindication 413712001
Blister contraindication 417237009
Denuded skin contraindication 418242004
Inflammatory dermatosis contraindication 703938007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Acetylcholinesterase Enzyme Ki 4.30 CHEMBL
Transient receptor potential cation channel subfamily A member 1 Ion channel GATING INHIBITOR IC50 4.20 IUPHAR

External reference:

IDSource
4017533 VUID
N0000145916 NUI
D00098 KEGG_DRUG
464-49-3 SECONDARY_CAS_RN
1298738 RXNORM
4017533 VANDF
C0006809 UMLSCUI
CHEBI:36773 CHEBI
CAM PDB_CHEM_ID
CHEMBL504760 ChEMBL_ID
DB01744 DRUGBANK_ID
D002164 MESH_DESCRIPTOR_UI
2537 PUBCHEM_CID
2422 IUPHAR_LIGAND_ID
C436264 MESH_SUPPLEMENTAL_RECORD_UI
DB11288 DRUGBANK_ID
DB14156 DRUGBANK_ID
4343 MMSL
6005 MMSL
001385 NDDF
001993 NDDF
005178 NDDF
006104 NDDF
111136003 SNOMEDCT_US
412108007 SNOMEDCT_US
46137002 SNOMEDCT_US
5TJD82A1ET UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Major Camphor and Phenol HUMAN OTC DRUG LABEL 2 00904-7851 LIQUID 10.80 g TOPICAL OTC monograph final 12 sections
AleveX HUMAN OTC DRUG LABEL 2 0280-0049 SPRAY 5.50 mg TOPICAL OTC monograph not final 15 sections
AleveX HUMAN OTC DRUG LABEL 2 0280-0049 SPRAY 5.50 mg TOPICAL OTC monograph not final 15 sections
AleveX HUMAN OTC DRUG LABEL 2 0280-0050 LOTION 5.50 mg TOPICAL OTC monograph not final 15 sections
AleveX HUMAN OTC DRUG LABEL 2 0280-0050 LOTION 5.50 mg TOPICAL OTC monograph not final 15 sections
AleveX HUMAN OTC DRUG LABEL 2 0280-0063 LOTION 5.50 mg TOPICAL OTC monograph not final 14 sections
AleveX HUMAN OTC DRUG LABEL 2 0280-0063 LOTION 5.50 mg TOPICAL OTC monograph not final 14 sections
Sarna HUMAN OTC DRUG LABEL 2 0316-0229 LOTION 5 mg TOPICAL OTC monograph not final 13 sections
Vaporizing HUMAN OTC DRUG LABEL 1 0363-0055 INHALANT 62 mg RESPIRATORY (INHALATION) OTC monograph final 15 sections
WALGREENS MEDICATED PAIN RELIEVING HUMAN OTC DRUG LABEL 3 0363-0149 PATCH 7.10 mg TOPICAL OTC monograph not final 14 sections
Walgreens Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0363-0407 CREAM 30 mg TOPICAL OTC monograph not final 10 sections
Walgreens Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0363-0407 CREAM 30 mg TOPICAL OTC monograph not final 10 sections
Pain Relief Patches HUMAN OTC DRUG LABEL 3 0363-0907 PATCH 3.10 g TOPICAL OTC monograph not final 11 sections
Walgreens Chest Rub HUMAN OTC DRUG LABEL 3 0363-1001 OINTMENT 48 mg TOPICAL OTC monograph final 12 sections
Walgreens Chest Rub HUMAN OTC DRUG LABEL 3 0363-1001 OINTMENT 48 mg TOPICAL OTC monograph final 12 sections
Walgreens Pain Relieving Analgesic HUMAN OTC DRUG LABEL 3 0363-1199 CREAM 40 mg TOPICAL OTC MONOGRAPH NOT FINAL 15 sections
No Touch Application Chest RubWell at Walgreens HUMAN OTC DRUG LABEL 3 0363-3267 STICK 4.80 g TOPICAL OTC monograph final 7 sections
Walgreen Anti Itch HUMAN OTC DRUG LABEL 2 0363-4262 LOTION 0.50 g TOPICAL OTC monograph not final 12 sections
Medicated Lip Balm HUMAN OTC DRUG LABEL 3 0363-6040 SALVE 1.70 mg TOPICAL OTC monograph not final 9 sections
Medicated Lip Balm HUMAN OTC DRUG LABEL 3 0363-6080 STICK 1.70 mg TOPICAL OTC monograph not final 9 sections
Chest Rub HUMAN OTC DRUG LABEL 3 0363-8480 LOTION 4.80 kg TOPICAL OTC monograph final 15 sections
Walgreens Camphor Phenol Gel HUMAN OTC DRUG LABEL 2 0363-9425 GEL 10.80 mg TOPICAL OTC monograph not final 8 sections
Pain Relieving Patches HUMAN OTC DRUG LABEL 3 0363-9903 PATCH 1.20 1 TOPICAL OTC monograph not final 12 sections
Large Pain Relieving HUMAN OTC DRUG LABEL 3 0363-9904 PATCH 3.10 g TOPICAL OTC monograph not final 13 sections
HUMCO Camphor Spirit HUMAN OTC DRUG LABEL 1 0395-0467 LIQUID 100 mg TOPICAL OTC monograph not final 13 sections
HUMCO Camphor Spirit HUMAN OTC DRUG LABEL 1 0395-0467 LIQUID 100 mg TOPICAL OTC monograph not final 13 sections
Camphor Spirit HUMAN OTC DRUG LABEL 1 0395-9112 LIQUID 100 mg TOPICAL OTC monograph not final 12 sections
Rugby Anti-Itch HUMAN OTC DRUG LABEL 2 0536-1268 LOTION 0.50 g TOPICAL OTC monograph not final 11 sections
ANBESOL COLD SORE THERAPY HUMAN OTC DRUG LABEL 4 0573-0246 OINTMENT 30 mg TOPICAL OTC monograph not final 14 sections
CHAPSTICK MEDICATED HUMAN OTC DRUG LABEL 4 0573-0720 STICK 10 mg TOPICAL OTC monograph not final 13 sections