felbinac 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibufenac derivatives 1141 5728-52-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dolinac
  • biphenylacetic acid
  • felbinac
  • seltouch
  • traxam
  • 4-Biphenylylacetic acid
  • p-Biphenylacetic acid
an anti-inflammatory/analgesic agent which has been developed into a topical gel for local treatment and pain and inflammation associated with conditions of the musculo-skeletal system
  • Molecular weight: 212.25
  • Formula: C14H12O2
  • CLOGP: 3.30
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -3.76
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.295 Moderate 0.71
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.416 Moderate 0.71
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 206.063 10^-6 cm/s Moderate 0.71
dh-clint Dog hepatocyte intrinsic clearance 4.808 uL/min/10^6 cells Moderate 0.71
dppb Dog plasma protein binding (% unbound) 1.420 % Moderate 0.71
fcs-ppb Fetal calf serum protein binding (% unbound) 2.650 % Moderate 0.71
herg hERG pIC50 4.101 pIC50 Moderate 0.71
hh-clint Human hepatocyte intrinsic clearance 1.574 uL/min/10^6 cells Moderate 0.71
hlm-clint Human liver microsomal intrinsic clearance 3.296 uL/min/mg protein Moderate 0.71
hppb Human plasma protein binding (% unbound) 1.340 % Moderate 0.71
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK7,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK,TGFBR1 23
kinase-selectivity-class AXL,GRK2 2
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.472 Moderate 0.71
mh-clint Mouse hepatocyte intrinsic clearance 21.038 Moderate 0.71
mppb Mouse plasma protein binding (% unbound) 9.780 Moderate 0.71
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.109 Moderate 0.71
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 1.970 % Moderate 0.71
rh-clint Rat hepatocyte intrinsic clearance 3.373 uL/min/10^6 cells Moderate 0.71
rh-fuinc Rat hepatocyte fraction unbound in incubation 83.650 % Moderate 0.71
rppb Rat plasma protein binding (% unbound) 1.390 % Moderate 0.71
solubility-dd Solubility at pH 7.4 in DMSO 954.993 uM Moderate 0.71

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M02AA08 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent

Related Drugs by ATC class:

M02AA Antiinflammatory preparations, non-steroids for topical use 28 drugs
aceclofenacbendazacbenzydaminebufexamacclofezonedexketoprofendiclofenacesflurbiprofenetofenamatefentiazacfeprazoneflurbiprofen show all 28 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Osteoarthritis indication 396275006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.4 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR KEGG DRUG KEGG DRUG
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 6.05 DRUG MATRIX KEGG DRUG

External reference:

IDSource
D01675 KEGG_DRUG
C0877860 UMLSCUI
CHEBI:31597 CHEBI
CHEMBL413965 ChEMBL_ID
DB07477 DRUGBANK_ID
3332 PUBCHEM_CID
C012776 MESH_SUPPLEMENTAL_RECORD_UI
5831 INN_ID
94WNJ5U8L7 UNII
225536 RXNORM
003698 NDDF
350320002 SNOMEDCT_US
396051001 SNOMEDCT_US
BP4 PDB_CHEM_ID

Pharmaceutical products:

None