felbinac Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibufenac derivatives 1141 5728-52-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dolinac
  • biphenylacetic acid
  • felbinac
  • seltouch
  • traxam
  • 4-Biphenylylacetic acid
  • p-Biphenylacetic acid
an anti-inflammatory/analgesic agent which has been developed into a topical gel for local treatment and pain and inflammation associated with conditions of the musculo-skeletal system
  • Molecular weight: 212.25
  • Formula: C14H12O2
  • CLOGP: 3.30
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -3.76
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC M02AA08 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Osteoarthritis indication 396275006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.4 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 6.05 DRUG MATRIX KEGG DRUG
Prostaglandin G/H synthase 2 Enzyme INHIBITOR KEGG DRUG KEGG DRUG

External reference:

IDSource
C0877860 UMLSCUI
D01675 KEGG_DRUG
350320002 SNOMEDCT_US
262307 RXNORM
396051001 SNOMEDCT_US
003698 NDDF
94WNJ5U8L7 UNII
5831 INN_ID
3332 PUBCHEM_CID
CHEBI:31597 CHEBI
CHEMBL413965 ChEMBL_ID
DB07477 DRUGBANK_ID
C012776 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None