dexibuprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory agents, ibuprofen derivatives	3851	51146-56-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dexibuprofen

Molecular weight: 206.29
Formula: C13H18O2
CLOGP: 3.68
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 37.30
ALOGS: -3.48
ROTB: 4

Drug dosage:

Dose	Unit	Route
0.80	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sopor	68.66	60.42	16	224	22148	63466634

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sopor	58.52	48.01	15	264	32995	79711114

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M01AE14	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory agent

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Pain	indication	22253000
Rheumatoid arthritis	indication	69896004	DOID:7148
Headache disorder	indication	230461009
Dysmenorrhea	indication	266599000
Fever	indication	386661006
Osteoarthritis	indication	396275006
Juvenile rheumatoid arthritis	indication	410795001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.37	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN		IC50	6.14		CHEMBL
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN		IC50	7.01		CHEMBL
Aldo-keto reductase family 1 member C2	Enzyme	P52895	AK1C2_HUMAN		IC50	4.37		CHEMBL
Aldo-keto reductase family 1 member C3	Enzyme	P42330	AK1C3_HUMAN		IC50	4.49		CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_SHEEP		IC50	5.83		CHEMBL
Prostaglandin G/H synthase 2	Enzyme		PGH2_SHEEP		IC50	5.82		CHEMBL

External reference:

ID	Source
D03715	KEGG_DRUG
C2714681	UMLSCUI
CHEBI:43415	CHEBI
IBP	PDB_CHEM_ID
CHEMBL175	ChEMBL_ID
DB09213	DRUGBANK_ID
39912	PUBCHEM_CID
C539402	MESH_SUPPLEMENTAL_RECORD_UI
6426	INN_ID
671DKG7P5S	UNII
006963	NDDF
418027007	SNOMEDCT_US
418868002	SNOMEDCT_US

Pharmaceutical products:

None