bufexamac Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3047 2438-72-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bufexamac
  • bufexamic acid
  • feximac
  • mofenar
  • parfenal
A benzeneacetamide with anti-inflammatory, analgesic, and antipyretic action. It is administered topically, orally, or rectally.
  • Molecular weight: 223.27
  • Formula: C12H17NO3
  • CLOGP: 1.85
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 58.56
  • ALOGS: -2.98
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AB17 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
ATC M02AA09 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drugs
CHEBI has role CHEBI:35493 anti-pyretic

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.5 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histone deacetylase 10 Enzyme INHIBITOR Kd 4.91 IUPHAR
Histone deacetylase 6 Enzyme INHIBITOR Kd 4.97 IUPHAR
Arachidonate 5-lipoxygenase Enzyme IC50 6.89 CHEMBL
M1-family alanyl aminopeptidase Unclassified IC50 4.09 CHEMBL

External reference:

IDSource
N0000166889 NUI
D01271 KEGG_DRUG
C0006351 UMLSCUI
CHEBI:31317 CHEBI
A4Z PDB_CHEM_ID
CHEMBL94394 ChEMBL_ID
DB13346 DRUGBANK_ID
D002019 MESH_DESCRIPTOR_UI
2557 INN_ID
2466 PUBCHEM_CID
7498 IUPHAR_LIGAND_ID
4T3C38J78L UNII
1796 RXNORM
003713 NDDF
273952005 SNOMEDCT_US
332124001 SNOMEDCT_US

Pharmaceutical products:

None