diphenhydramine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
916 58-73-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benadryl
  • diphenhydramine salicylate
  • diphenhydramine laurylsulfate
  • diphenhydramine
  • benzhydramine
  • probedryl
  • diphenhydramine hydrochloride
  • diphenhydramine citrate
  • diphenhydramine HCl
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
  • Molecular weight: 255.36
  • Formula: C17H21NO
  • CLOGP: 3.45
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 12.47
  • ALOGS: -3.53
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P
0.20 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1000 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 3.26 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 72 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 6.50 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 9.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.19 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.30 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.563 Moderate 0.73
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.054 Moderate 0.73
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 26.062 10^-6 cm/s Moderate 0.73
dh-clint Dog hepatocyte intrinsic clearance 49.774 uL/min/10^6 cells Moderate 0.73
dppb Dog plasma protein binding (% unbound) 43.700 % Moderate 0.73
fcs-ppb Fetal calf serum protein binding (% unbound) 38.910 % Moderate 0.73
herg hERG pIC50 5.185 pIC50 Moderate 0.73
hh-clint Human hepatocyte intrinsic clearance 3.639 uL/min/10^6 cells Moderate 0.73
hlm-clint Human liver microsomal intrinsic clearance 5.929 uL/min/mg protein Moderate 0.73
hppb Human plasma protein binding (% unbound) 40.170 % Moderate 0.73
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK 47
kinase-selectivity-class AXL,ERBB2,GRK2,PDK4,TEK 5
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.560 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.593 Moderate 0.73
mh-clint Mouse hepatocyte intrinsic clearance 80.538 Moderate 0.73
mppb Mouse plasma protein binding (% unbound) 49.770 Moderate 0.73
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.143 Moderate 0.73
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 63.630 % Moderate 0.73
rat-kpuu-brain Rat brain Kpuu 1.059 % High 1
rh-clint Rat hepatocyte intrinsic clearance 237.684 uL/min/10^6 cells Moderate 0.73
rh-fuinc Rat hepatocyte fraction unbound in incubation 66.050 % Moderate 0.73
rppb Rat plasma protein binding (% unbound) 52.820 % Moderate 0.73
solubility-dd Solubility at pH 7.4 in DMSO 952.796 uM Moderate 0.73

Approvals:

DateAgencyCompanyOrphan
March 4, 1946 FDA MCNEIL CONS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 5260.95 10.08 10881 1051353 276965 89289248
Completed suicide 4348.26 10.08 6807 1055427 138251 89427962
Exposure to toxic agent 1719.24 10.08 1105 1061129 6862 89559351
Intentional overdose 1536.29 10.08 3397 1058837 90437 89475776
Overdose 1112.16 10.08 4217 1058017 153492 89412721
Infusion related reaction 976.43 10.08 8274 1053960 408506 89157707
Acute hepatic failure 970.55 10.08 1259 1060975 21302 89544911
Suicide attempt 557.64 10.08 2048 1060186 73351 89492862
Drug ineffective 557.49 10.08 12189 1050045 1372109 88194104
Intentional product misuse 547.67 10.08 2292 1059942 87312 89478901
Hepatic cytolysis 540.77 10.08 1150 1061084 29766 89536447
Blood pressure fluctuation 532.06 10.08 1585 1060649 50828 89515385
Drug abuse 525.83 10.08 2135 1060099 80212 89486001
Injection site pain 494.04 10.08 795 1061439 172904 89393309
Throat irritation 446.29 10.08 1421 1060813 47274 89518939
Product dose omission issue 445.66 10.08 1831 1060403 289856 89276357
Metabolic acidosis 430.93 10.08 1535 1060699 54141 89512072
Poisoning deliberate 386.69 10.08 694 1061540 15792 89550421
Urticaria 359.86 10.08 5402 1056832 307332 89258881
Analgesic drug level increased 359.79 10.08 288 1061946 2631 89563582
Flushing 342.39 10.08 1987 1060247 86504 89479709
Device expulsion 337.50 10.08 41 1062193 40845 89525368
Cardio-respiratory arrest 321.59 10.08 1530 1060704 61610 89504603
Suspected suicide 308.55 10.08 465 1061769 9103 89557110
Sinusitis 305.23 10.08 5683 1056551 337405 89228808
Diarrhoea 285.03 10.08 8611 1053623 930579 88635634
Anaemia 277.12 10.08 2719 1059515 350083 89216130
Malignant neoplasm progression 274.82 10.08 521 1061713 106349 89459864
Suspected suicide attempt 258.60 10.08 150 1062084 751 89565462
Respiratory arrest 257.40 10.08 918 1061316 32393 89533820
Cardiac failure congestive 235.91 10.08 502 1061732 98192 89468021
Blood pressure diastolic abnormal 235.69 10.08 636 1061598 19245 89546968
Blood pressure systolic increased 235.44 10.08 1325 1060909 57020 89509193
Myelosuppression 234.74 10.08 171 1062063 53420 89512793
Cardiac failure 230.46 10.08 596 1061638 108900 89457313
Neutropenia 230.28 10.08 1615 1060619 223289 89342924
Anion gap 223.46 10.08 149 1062085 993 89565220
Disease progression 223.15 10.08 1009 1061225 155606 89410607
Lower respiratory tract infection 221.71 10.08 4149 1058085 246510 89319703
Folliculitis 217.65 10.08 3485 1058749 200868 89365345
Blood pressure systolic abnormal 216.90 10.08 609 1061625 18869 89547344
Injection site erythema 204.37 10.08 540 1061694 97962 89468251
Oxygen saturation decreased 203.86 10.08 2041 1060193 105442 89460771
Pruritus 202.05 10.08 8009 1054225 533516 89032697
Pyroglutamic acidosis 198.95 10.08 145 1062089 1135 89565078
Muscle injury 197.73 10.08 3038 1059196 173616 89392597
Irritable bowel syndrome 195.77 10.08 3469 1058765 203979 89362234
Ear pruritus 193.42 10.08 312 1061922 6491 89559722
Wrong technique in product usage process 187.45 10.08 345 1061889 71226 89494987
Hypersensitivity 183.40 10.08 6783 1055451 447894 89118319
Therapy interrupted 178.49 10.08 194 1062040 49914 89516299
Ill-defined disorder 178.08 10.08 3102 1059132 181789 89384424
Blood pressure increased 178.00 10.08 3275 1058959 193942 89372271
Heart rate increased 177.49 10.08 2065 1060169 110837 89455376
Medication error 177.06 10.08 1641 1060593 83011 89483202
Depressed level of consciousness 176.15 10.08 1457 1060777 71327 89494886
Renal impairment 176.07 10.08 638 1061596 104783 89461430
Impaired healing 171.70 10.08 3770 1058464 230429 89335784
Body temperature increased 170.34 10.08 1000 1061234 43710 89522503
Heart rate decreased 168.56 10.08 1140 1061094 52365 89513848
Pancytopenia 164.08 10.08 787 1061447 119476 89446737
Nasopharyngitis 163.80 10.08 6072 1056162 401032 89165181
Blood pressure diastolic decreased 162.89 10.08 685 1061549 26141 89540072
Exposure via ingestion 161.16 10.08 177 1062057 2490 89563723
Poisoning 158.99 10.08 465 1061769 14752 89551461
Injection site bruising 158.64 10.08 229 1062005 52078 89514135
Intentional product use issue 156.31 10.08 3483 1058751 213409 89352804
Blister 155.86 10.08 4003 1058231 250995 89315218
Hospitalisation 154.16 10.08 875 1061359 127225 89438988
Therapy cessation 149.13 10.08 124 1062110 36237 89529976
Drug resistance 142.93 10.08 90 1062144 30359 89535854
Rheumatoid arthritis 140.20 10.08 5385 1056849 357229 89208984
Osteonecrosis of jaw 139.71 10.08 151 1062083 38952 89527261
Throat tightness 139.04 10.08 699 1061535 28785 89537428
Sleep disorder due to general medical condition, insomnia type 136.29 10.08 2193 1060041 126501 89439712
Duodenal ulcer perforation 136.14 10.08 3477 1058757 217811 89348402
Hepatotoxicity 131.65 10.08 955 1061279 44887 89521326
Infusion site pruritus 129.26 10.08 261 1061973 6504 89559709
Neoplasm progression 127.91 10.08 202 1062032 44284 89521929
Helicobacter infection 127.08 10.08 3521 1058713 223329 89342884
Neuropathy peripheral 126.12 10.08 1013 1061221 135957 89430256
Abortion spontaneous 124.18 10.08 281 1061953 53775 89512438
Myocardial infarction 122.09 10.08 734 1061500 105238 89460975
Infusion site erythema 121.67 10.08 395 1061839 13275 89552938
Infusion site swelling 120.40 10.08 356 1061878 11364 89554849
Coagulopathy 119.03 10.08 565 1061669 22724 89543489
Infusion site pain 118.28 10.08 502 1061732 19236 89546977
Urine abnormality 117.47 10.08 272 1061962 7465 89558748
Renal failure 116.47 10.08 978 1061256 130029 89436184
Therapeutic product effect incomplete 113.82 10.08 1593 1060641 192303 89373910
Hepatic enzyme increased 112.71 10.08 5239 1056995 355497 89210716
Device dislocation 107.63 10.08 126 1062108 31356 89534857
White blood cell count decreased 107.54 10.08 1347 1060887 165762 89400451
Sopor 107.45 10.08 79 1062155 24565 89541648
Anticholinergic syndrome 104.07 10.08 144 1062090 2599 89563614
Interstitial lung disease 103.62 10.08 501 1061733 75904 89490309
Prothrombin time ratio decreased 103.54 10.08 89 1062145 906 89565307
Respiratory failure 103.03 10.08 889 1061345 117529 89448684
Product substitution issue 102.90 10.08 41 1062193 17967 89548246
Surgery 102.57 10.08 234 1062000 44653 89521560
Anti-cyclic citrullinated peptide antibody positive 101.46 10.08 3553 1058681 232880 89333333
Urine leukocyte esterase positive 100.88 10.08 156 1062078 3126 89563087
Product storage error 100.41 10.08 56 1062178 20185 89546028
Pericarditis 100.36 10.08 3995 1058239 266156 89300057
Hyperkalaemia 99.55 10.08 407 1061827 64557 89501656
Gastrointestinal disorder 99.14 10.08 3812 1058422 252875 89313338
Accidental overdose 98.57 10.08 618 1061616 27655 89538558
Weight increased 97.09 10.08 5903 1056331 412024 89154189
Acute kidney injury 96.00 10.08 2940 1059294 317447 89248766
Atrial fibrillation 95.22 10.08 1053 1061181 132558 89433655
Leukopenia 94.94 10.08 740 1061494 99970 89466243
Cytokine release syndrome 94.77 10.08 607 1061627 27366 89538847
Posterior reversible encephalopathy syndrome 94.34 10.08 74 1062160 22265 89543948
Full blood count abnormal 93.54 10.08 179 1062055 36418 89529795
Hyponatraemia 92.96 10.08 1058 1061176 132480 89433733
Food allergy 92.65 10.08 563 1061671 24915 89541298
Psoriasis 92.46 10.08 1198 1061036 146556 89419657
Pharyngeal paraesthesia 92.20 10.08 147 1062087 3027 89563186
Poor venous access 92.11 10.08 463 1061771 19064 89547149
Breast cancer 91.99 10.08 322 1061912 53439 89512774
Pulmonary hypertension 89.80 10.08 231 1062003 42292 89523921
Cerebrovascular accident 88.25 10.08 973 1061261 122560 89443653
Device difficult to use 87.64 10.08 48 1062186 17477 89548736
Drug interaction 87.49 10.08 2518 1059716 273935 89292278
Fall 87.32 10.08 4686 1057548 477124 89089089
Liver injury 86.29 10.08 2614 1059620 167953 89398260
Synovitis 84.47 10.08 4699 1057535 325053 89241160
Device malfunction 84.23 10.08 73 1062161 20904 89545309
Diabetes mellitus 83.62 10.08 433 1061801 64442 89501771
Injury 83.24 10.08 2960 1059274 194389 89371824
Dehydration 78.56 10.08 1708 1060526 192739 89373474
Injection site swelling 78.48 10.08 397 1061837 59442 89506771
Hereditary angioedema 78.34 10.08 265 1061969 9100 89557113
Tachycardia 78.05 10.08 2410 1059824 155263 89410950
Dyspnoea exertional 77.94 10.08 511 1061723 71777 89494436
Sepsis 77.78 10.08 1562 1060672 178252 89387961
Haematotoxicity 77.65 10.08 25 1062209 12510 89553703
Chest discomfort 77.54 10.08 2148 1060086 136217 89429996
Thrombocytopenia 77.12 10.08 1859 1060375 206866 89359347
Stomatitis 77.04 10.08 3948 1058286 270750 89295463
Crystal urine present 75.04 10.08 90 1062144 1400 89564813
Accidental exposure to product 75.03 10.08 250 1061984 42116 89524097
Myelodysplastic syndrome 74.36 10.08 81 1062153 20822 89545391
White blood cells urine positive 74.15 10.08 205 1062029 6293 89559920
Infusion site extravasation 73.36 10.08 277 1061957 10051 89556162
Anaphylactic reaction 72.24 10.08 1434 1060800 86090 89480123
Hepatic failure 72.22 10.08 748 1061486 38980 89527233
Coma 71.45 10.08 1223 1061011 71409 89494804
Pneumonia 70.03 10.08 6482 1055752 631577 88934636
Joint swelling 69.84 10.08 6827 1055407 496473 89069740
Drug dose omission by device 69.71 10.08 17 1062217 10214 89555999
Unevaluable event 69.61 10.08 368 1061866 54480 89511733
Syncope 69.53 10.08 1114 1061120 131549 89434664
Thrombotic microangiopathy 69.24 10.08 50 1062184 15693 89550520
Urinary sediment present 69.17 10.08 105 1062129 2069 89564144
Bone marrow failure 68.84 10.08 174 1062060 32047 89534166
Visual acuity reduced 68.54 10.08 105 1062129 23305 89542908
Injection site haemorrhage 68.52 10.08 143 1062091 28175 89538038
Metastases to bone 68.52 10.08 121 1062113 25384 89540829
Acute lung injury 68.20 10.08 86 1062148 1412 89564801
Disease recurrence 68.19 10.08 220 1062014 37433 89528780
Pulmonary arterial hypertension 67.88 10.08 127 1062107 26060 89540153
Injection site pruritus 67.87 10.08 362 1061872 53472 89512741
Metastases to liver 67.59 10.08 148 1062086 28659 89537554
Pneumocystis jirovecii pneumonia 67.16 10.08 93 1062141 21523 89544690
Hypothyroidism 66.56 10.08 358 1061876 52769 89513444
Polyneuropathy 66.56 10.08 77 1062157 19264 89546949
Premature delivery 66.42 10.08 232 1062002 38530 89527683
Platelet count decreased 65.97 10.08 1168 1061066 135801 89430412
Device adhesion issue 65.64 10.08 3 1062231 6688 89559525
Gastrointestinal haemorrhage 65.59 10.08 708 1061526 89540 89476673
Mydriasis 65.30 10.08 348 1061886 14664 89551549
Hepatic necrosis 64.66 10.08 194 1062040 6244 89559969
Sedation complication 64.55 10.08 379 1061855 16565 89549648
Diabetic ketoacidosis 64.48 10.08 117 1062117 24290 89541923
Respiratory depression 64.34 10.08 356 1061878 15219 89550994
Transient ischaemic attack 63.98 10.08 274 1061960 42902 89523311
Blood pressure diastolic increased 63.71 10.08 310 1061924 12596 89553617
Pyroglutamate increased 63.71 10.08 44 1062190 313 89565900
Cytomegalovirus infection 62.97 10.08 136 1062098 26466 89539747
Muscle spasticity 62.77 10.08 662 1061572 34660 89531553
Deafness transitory 62.64 10.08 97 1062137 1946 89564267
Pathogen resistance 62.59 10.08 10 1062224 8105 89558108
Post transplant lymphoproliferative disorder 62.50 10.08 5 1062229 6944 89559269
Temperature regulation disorder 62.08 10.08 336 1061898 14243 89551970
Respiratory rate increased 61.66 10.08 359 1061875 15642 89550571
Multiple-drug resistance 61.31 10.08 9 1062225 7767 89558446
Chronic kidney disease 60.81 10.08 342 1061892 49849 89516364
Postmortem blood drug level increased 60.66 10.08 57 1062177 658 89565555
Discomfort 60.51 10.08 3858 1058376 270477 89295736
Septic shock 60.05 10.08 663 1061571 83497 89482716
Full blood count decreased 59.87 10.08 165 1062069 29524 89536689
Myalgia 58.72 10.08 1582 1060652 173543 89392670
Erythema 57.92 10.08 3263 1058971 225983 89340230
Confusional state 57.75 10.08 5267 1056967 380938 89185275
Product use in unapproved indication 57.74 10.08 3287 1058947 332949 89233264
Breast cancer female 57.15 10.08 54 1062180 14832 89551381
Blood glucose increased 56.76 10.08 780 1061454 94466 89471747
Osteonecrosis 56.61 10.08 141 1062093 26100 89540113
Transplant rejection 55.49 10.08 41 1062193 12717 89553496
Right ventricular failure 55.40 10.08 87 1062147 19118 89547095
Product prescribing error 55.38 10.08 175 1062059 29970 89536243
Somnolence 55.37 10.08 2989 1059245 206095 89360118
Palmar-plantar erythrodysaesthesia syndrome 54.84 10.08 158 1062076 27865 89538348
Dry skin 54.75 10.08 715 1061519 87358 89478855
Coronary artery disease 54.47 10.08 206 1062028 33417 89532796
Pharyngitis 53.97 10.08 441 1061793 21506 89544707
Hypertensive crisis 53.78 10.08 78 1062156 17706 89548507
Schizoaffective disorder 53.50 10.08 157 1062077 4990 89561223
Creatinine renal clearance decreased 53.28 10.08 392 1061842 18507 89547706
Renal disorder 52.64 10.08 246 1061988 37613 89528600
Peripheral swelling 52.58 10.08 5571 1056663 407535 89158678
Injection site mass 52.23 10.08 113 1062121 21977 89544236
Lymphocyte count decreased 51.94 10.08 634 1061600 34416 89531797
Acute myeloid leukaemia 51.84 10.08 102 1062132 20538 89545675
Mucosal inflammation 51.28 10.08 430 1061804 57195 89509018
Ear pain 50.88 10.08 955 1061279 56747 89509466
Red blood cells urine positive 50.76 10.08 115 1062119 3110 89563103
Oral pruritus 50.71 10.08 109 1062125 2842 89563371
Neurotoxicity 50.61 10.08 110 1062124 21357 89544856
Hypokalaemia 50.57 10.08 1160 1061074 129956 89436257
Anion gap abnormal 50.44 10.08 39 1062195 337 89565876
Brain oedema 50.39 10.08 363 1061871 17022 89549191
Lactic acidosis 50.30 10.08 365 1061869 50098 89516115
Heart rate irregular 49.99 10.08 469 1061765 23799 89542414
Suicidal ideation 49.89 10.08 589 1061645 73266 89492947
Feeling hot 49.77 10.08 1232 1061002 76776 89489437
Second primary malignancy 49.65 10.08 30 1062204 10348 89555865
Urinary tract infection 49.56 10.08 3004 1059230 302628 89263585
Unintentional medical device removal 49.25 10.08 11 1062223 7019 89559194
Haemorrhage 48.89 10.08 548 1061686 68821 89497392
Cardiac failure acute 48.52 10.08 41 1062193 11888 89554325
Hand deformity 48.51 10.08 4069 1058165 292293 89273920
Device issue 48.48 10.08 180 1062054 29357 89536856
Treatment noncompliance 48.31 10.08 381 1061853 51346 89514867
Rheumatic fever 47.98 10.08 2225 1060009 150896 89415317
Hypocalcaemia 47.97 10.08 295 1061939 42073 89524140
Cardiac arrest 47.76 10.08 1588 1060646 103347 89462866
Hypocoagulable state 47.75 10.08 75 1062159 1524 89564689
Cerebral haemorrhage 47.60 10.08 225 1062009 34297 89531916
Body temperature decreased 47.44 10.08 457 1061777 23359 89542854
Complication of device insertion 47.41 10.08 32 1062202 10404 89555809
Multiple organ dysfunction syndrome 47.31 10.08 542 1061692 67794 89498419
Injection site warmth 47.13 10.08 83 1062151 17432 89548781
Cerebral infarction 47.05 10.08 157 1062077 26439 89539774
Hepatic function abnormal 47.01 10.08 333 1061901 45955 89520258
Mobility decreased 46.66 10.08 3477 1058757 247257 89318956
Pyrexia 46.51 10.08 8602 1053632 651883 88914330
Infusion site rash 46.49 10.08 95 1062139 2388 89563825
Injection site reaction 45.04 10.08 783 1061451 91297 89474916
Exposure via skin contact 44.53 10.08 36 1062198 10669 89555544
Seizure 44.34 10.08 1406 1060828 151223 89414990
Foetal exposure during pregnancy 44.22 10.08 308 1061926 42667 89523546
Hypomania 44.13 10.08 214 1062020 8683 89557530
Swelling 43.88 10.08 5581 1056653 413477 89152736
Plasma cell myeloma 43.81 10.08 289 1061945 40539 89525674
Metastases to lung 43.74 10.08 75 1062159 15916 89550297
Injection site rash 43.25 10.08 142 1062092 24031 89542182
Therapeutic product effect decreased 42.76 10.08 3794 1058440 273777 89292436
Alopecia 42.55 10.08 5116 1057118 489955 89076258
Prothrombin time shortened 42.47 10.08 87 1062147 2191 89564022
Hepatitis acute 42.43 10.08 245 1061989 10642 89555571
Drug use disorder 42.34 10.08 202 1062032 8141 89558072
Ascites 42.13 10.08 357 1061877 47383 89518830
Oedema peripheral 41.98 10.08 2534 1059700 255381 89310832
Hyperglycaemia 41.97 10.08 388 1061846 50582 89515631
Infection 41.51 10.08 4850 1057384 357244 89208969
Impaired quality of life 41.37 10.08 136 1062098 23008 89543205
Incorrect drug administration rate 41.25 10.08 145 1062089 5078 89561135
Lymphocyte percentage decreased 41.12 10.08 104 1062130 3023 89563190
Cellulitis 41.12 10.08 788 1061446 90549 89475664
Immunodeficiency 41.08 10.08 724 1061510 42510 89523703
Cytopenia 40.65 10.08 90 1062144 17359 89548854
Product dose omission in error 40.56 10.08 115 1062119 20388 89545825
Dissociation 40.53 10.08 14 1062220 6701 89559512
Blood calcium decreased 40.49 10.08 536 1061698 29646 89536567
Infusion site bruising 40.42 10.08 128 1062106 4244 89561969
Ductus arteriosus premature closure 40.26 10.08 36 1062198 388 89565825
Incorrect dose administered by device 40.14 10.08 9 1062225 5728 89560485
Chills 40.11 10.08 1912 1060322 130069 89436144
Carpal tunnel syndrome 39.81 10.08 145 1062089 23783 89542430
Ischaemic stroke 39.80 10.08 130 1062104 22036 89544177
Electric shock 39.76 10.08 72 1062162 1650 89564563
Inappropriate schedule of product administration 39.60 10.08 2143 1060091 147790 89418423
Vision blurred 39.44 10.08 987 1061247 109306 89456907
Haemophagocytic lymphohistiocytosis 39.17 10.08 76 1062158 15383 89550830
Accidental death 39.11 10.08 79 1062155 1969 89564244
Cholecystitis chronic 38.87 10.08 222 1062012 9604 89556609
Spinal stenosis 38.87 10.08 92 1062142 17332 89548881
Cardiac disorder 38.62 10.08 453 1061781 56419 89509794
Neutrophil percentage increased 38.58 10.08 99 1062135 2904 89563309
Rash erythematous 38.54 10.08 1018 1061216 64086 89502127
Electrocardiogram QRS complex prolonged 38.08 10.08 179 1062055 7169 89559044
Vaginal haemorrhage 37.92 10.08 213 1062021 31058 89535155
Hepatitis fulminant 37.86 10.08 117 1062117 3828 89562385
Hip fracture 37.61 10.08 230 1062004 32847 89533366
Ovarian hyperstimulation syndrome 37.56 10.08 11 1062223 5851 89560362
Unresponsive to stimuli 37.53 10.08 642 1061592 37479 89528734
Infusion site urticaria 37.44 10.08 70 1062164 1645 89564568
Device use error 37.25 10.08 19 1062215 7202 89559011
No adverse event 37.25 10.08 566 1061668 67416 89498797
Immune reconstitution inflammatory syndrome 36.92 10.08 18 1062216 7001 89559212
Cognitive disorder 36.78 10.08 1070 1061164 68337 89497876
Bursitis 36.62 10.08 1891 1060343 129763 89436450
Systemic infection 36.57 10.08 6 1062228 4769 89561444
Brain death 36.52 10.08 117 1062117 3904 89562309
Drug ineffective for unapproved indication 36.47 10.08 555 1061679 66089 89500124
Complication associated with device 36.37 10.08 112 1062122 19337 89546876
Depression 36.23 10.08 3031 1059203 297570 89268643
Epistaxis 36.03 10.08 742 1061492 84383 89481830
Decreased appetite 35.98 10.08 3863 1058371 372677 89193536
Urine ketone body present 35.80 10.08 87 1062147 2465 89563748
Gestational diabetes 35.48 10.08 43 1062191 10539 89555674
Thrombosis 35.14 10.08 625 1061609 72626 89493587
Blood urine present 35.14 10.08 333 1061901 16945 89549268
Administration site swelling 35.02 10.08 63 1062171 1436 89564777
Specific gravity urine decreased 34.74 10.08 45 1062189 760 89565453
Fracture 34.64 10.08 137 1062097 21939 89544274
Mitral valve incompetence 34.57 10.08 141 1062093 22383 89543830
Hepatic encephalopathy 34.55 10.08 278 1061956 13494 89552719
Jaundice cholestatic 34.06 10.08 218 1062016 9825 89556388
Unintended pregnancy 33.92 10.08 24 1062210 7613 89558600
Bone pain 33.64 10.08 517 1061717 61466 89504747
Intermenstrual bleeding 33.63 10.08 35 1062199 9188 89557025
Acute myocardial infarction 33.51 10.08 255 1061979 34635 89531578
Endophthalmitis 33.49 10.08 7 1062227 4678 89561535
Gait disturbance 33.47 10.08 2613 1059621 257883 89308330
Hypotension 33.32 10.08 4328 1057906 321069 89245144
Night sweats 33.31 10.08 1837 1060397 126929 89439284
Pharyngeal swelling 33.20 10.08 215 1062019 9729 89556484
Therapeutic response decreased 33.16 10.08 799 1061435 88930 89477283
Hyperlipidaemia 32.99 10.08 147 1062087 22769 89543444
Wound 32.96 10.08 4045 1058189 298935 89267278
Drug level increased 32.79 10.08 482 1061752 27280 89538933
Hepatitis B reactivation 32.76 10.08 4 1062230 3970 89562243
Oropharyngeal discomfort 32.75 10.08 178 1062056 7557 89558656
Ageusia 32.67 10.08 89 1062145 15987 89550226
Therapy partial responder 32.59 10.08 140 1062094 21903 89544310
Bronchopulmonary aspergillosis 32.53 10.08 52 1062182 11346 89554867
Anion gap increased 32.50 10.08 78 1062156 2192 89564021
Pleural effusion 32.43 10.08 1032 1061202 110959 89455254
Body temperature fluctuation 32.39 10.08 78 1062156 2197 89564016
Therapeutic response unexpected 32.33 10.08 139 1062095 21741 89544472
Aspergillus infection 32.21 10.08 48 1062186 10775 89555438
Swollen joint count increased 31.89 10.08 1602 1060632 109604 89456609
Ear infection 31.76 10.08 1056 1061178 68719 89497494
Graft versus host disease in skin 31.47 10.08 4 1062230 3849 89562364
Abortion induced 31.39 10.08 57 1062177 11831 89554382
Maternal exposure during pregnancy 31.39 10.08 3717 1058517 356346 89209867
Coeliac disease 31.34 10.08 714 1061520 43896 89522317
Cardiomyopathy 31.32 10.08 126 1062108 20080 89546133
Inappropriate antidiuretic hormone secretion 31.27 10.08 120 1062114 19385 89546828
Pain in jaw 31.14 10.08 386 1061848 47599 89518614
Schizophrenia 31.11 10.08 289 1061945 14625 89551588
Analgesic drug level above therapeutic 30.90 10.08 21 1062213 145 89566068
Anuria 30.90 10.08 81 1062153 14737 89551476
Chronic obstructive pulmonary disease 30.81 10.08 645 1061589 73184 89493029
Hypervolaemia 30.72 10.08 241 1061993 32516 89533697
Device breakage 30.66 10.08 75 1062159 13969 89552244
Genital haemorrhage 30.65 10.08 34 1062200 8668 89557545
Weight fluctuation 30.47 10.08 360 1061874 19389 89546824
Neutrophil count decreased 30.43 10.08 623 1061611 70909 89495304
Sensitisation 30.34 10.08 6 1062228 4169 89562044
Contusion 30.27 10.08 3376 1058858 247840 89318373
Infective pulmonary exacerbation of cystic fibrosis 30.19 10.08 46 1062188 10233 89555980
Toxicologic test abnormal 30.16 10.08 40 1062194 692 89565521
Hypomagnesaemia 30.13 10.08 269 1061965 35319 89530894
Sleep disorder due to a general medical condition 30.13 10.08 357 1061877 44381 89521832
Atypical femur fracture 30.11 10.08 19 1062215 6402 89559811
Infusion site mass 30.04 10.08 74 1062160 2115 89564098
Complication of device removal 30.04 10.08 18 1062216 6237 89559976
Acute respiratory failure 29.86 10.08 340 1061894 42578 89523635
Pericardial effusion 29.63 10.08 282 1061952 36551 89529662
Blood potassium decreased 29.46 10.08 388 1061846 47339 89518874
Breast cancer stage I 29.31 10.08 42 1062192 9582 89556631
Left ventricular dysfunction 29.23 10.08 82 1062152 14587 89551626
Injection site discolouration 29.05 10.08 40 1062194 9280 89556933
Forced expiratory volume decreased 28.91 10.08 16 1062218 5792 89560421
Dyskinesia 28.85 10.08 281 1061953 36253 89529960
Loss of personal independence in daily activities 28.82 10.08 1302 1060932 134803 89431410
Acute graft versus host disease 28.79 10.08 14 1062220 5454 89560759
Personality change 28.77 10.08 26 1062208 7295 89558918
Blood iron abnormal 28.75 10.08 6 1062228 4014 89562199
Injection site induration 28.72 10.08 49 1062185 10419 89555794
Cytomegalovirus viraemia 28.56 10.08 28 1062206 7558 89558655
Multiple sclerosis relapse 28.48 10.08 436 1061798 51869 89514344
Dysgeusia 28.32 10.08 439 1061795 52121 89514092
Rash 28.02 10.08 10060 1052174 786040 88780173
Cytomegalovirus infection reactivation 28.00 10.08 30 1062204 7770 89558443
Drug-induced liver injury 27.98 10.08 1311 1060923 89007 89477206
Pneumonia viral 27.79 10.08 188 1062046 8635 89557578
Large intestine polyp 27.57 10.08 42 1062192 9344 89556869
Colorectal cancer 27.46 10.08 6 1062228 3887 89562326
Metastases to central nervous system 27.44 10.08 109 1062125 17433 89548780
Varicella zoster virus infection 27.29 10.08 6 1062228 3871 89562342
Ankylosing spondylitis 27.23 10.08 72 1062162 13061 89553152
Haematochezia 27.16 10.08 628 1061606 70285 89495928
Cardiotoxicity 27.14 10.08 58 1062176 11331 89554882
Transplant dysfunction 27.10 10.08 14 1062220 5268 89560945
Pancreatic carcinoma 27.08 10.08 35 1062199 8342 89557871
Drug withdrawal syndrome 27.08 10.08 211 1062023 28512 89537701
Amenorrhoea 26.86 10.08 61 1062173 11661 89554552
Condition aggravated 26.84 10.08 6379 1055855 589166 88977047
Hypothermia 26.78 10.08 290 1061944 15285 89550928
Macular oedema 26.73 10.08 12 1062222 4897 89561316
Mucormycosis 26.73 10.08 6 1062228 3815 89562398
Haemoglobin urine present 26.64 10.08 39 1062195 743 89565470
Infusion site nodule 26.63 10.08 61 1062173 1662 89564551
Skin cancer 26.62 10.08 76 1062158 13443 89552770
Product monitoring error 26.53 10.08 10 1062224 4534 89561679
C-reactive protein abnormal 26.25 10.08 1782 1060452 125647 89440566
Iron deficiency anaemia 26.14 10.08 166 1062068 23496 89542717
Chronic graft versus host disease 26.09 10.08 8 1062226 4131 89562082
Epstein-Barr virus infection 26.08 10.08 51 1062183 10293 89555920
Nephropathy toxic 25.97 10.08 70 1062164 12618 89553595
Invasive ductal breast carcinoma 25.97 10.08 32 1062202 7786 89558427
Product adhesion issue 25.83 10.08 14 1062220 5128 89561085
Tardive dyskinesia 25.77 10.08 56 1062178 10874 89555339
Diffuse large B-cell lymphoma recurrent 25.77 10.08 5 1062229 3521 89562692
Peritonitis 25.68 10.08 131 1062103 19574 89546639
Congestive cardiomyopathy 25.61 10.08 29 1062205 7325 89558888
Electrolyte imbalance 25.51 10.08 168 1062066 23577 89542636
Febrile bone marrow aplasia 25.44 10.08 47 1062187 9691 89556522
Haematuria 25.41 10.08 274 1061960 34663 89531550
Angioedema 25.36 10.08 965 1061269 63911 89502302
Graft versus host disease 25.34 10.08 35 1062199 8109 89558104
Rheumatoid factor positive 25.31 10.08 2339 1059895 169311 89396902
Infusion site haemorrhage 25.31 10.08 128 1062106 5283 89560930
Anticipatory anxiety 25.28 10.08 49 1062185 1184 89565029
Dysphoria 25.22 10.08 21 1062213 6133 89560080
Device deployment issue 25.20 10.08 13 1062221 4896 89561317
Headache 25.15 10.08 10830 1051404 851916 88714297
Low turnover osteopathy 25.11 10.08 9 1062225 4209 89562004
Cardiovascular disorder 25.01 10.08 78 1062156 13414 89552799
Cryopyrin associated periodic syndrome 24.90 10.08 32 1062202 536 89565677
Product physical issue 24.86 10.08 18 1062216 5642 89560571
Hypoglycaemic coma 24.67 10.08 3 1062231 2987 89563226
Dysstasia 24.58 10.08 182 1062052 24870 89541343
Thinking abnormal 24.56 10.08 64 1062170 11668 89554545
Device leakage 24.55 10.08 50 1062184 9941 89556272
Intentional dose omission 24.46 10.08 116 1062118 17667 89548546
Visual impairment 24.34 10.08 1285 1060949 131080 89435133
Heart rate abnormal 24.34 10.08 136 1062098 5835 89560378
Blood cholesterol increased 24.32 10.08 2790 1059444 205222 89360991
Ductus arteriosus stenosis foetal 24.26 10.08 21 1062213 216 89565997
Sexual dysfunction 24.25 10.08 13 1062221 4791 89561422
Arthropathy 24.05 10.08 4754 1057480 361488 89204725
Spinal compression fracture 23.94 10.08 94 1062140 15084 89551129
Opiates positive 23.92 10.08 24 1062210 302 89565911
Sleep apnoea syndrome 23.89 10.08 247 1061987 31500 89534713
Alanine aminotransferase increased 23.87 10.08 1652 1060582 116686 89449527
Lymphoproliferative disorder 23.87 10.08 10 1062224 4252 89561961
Product preparation error 23.84 10.08 53 1062181 10208 89556005
Acute graft versus host disease in skin 23.82 10.08 13 1062221 4743 89561470
Muscle spasms 23.79 10.08 2586 1059648 249297 89316916
Blood pH decreased 23.75 10.08 75 1062159 2483 89563730
Prescribed overdose 23.75 10.08 1385 1060849 96240 89469973
Heavy menstrual bleeding 23.74 10.08 142 1062092 20388 89545825
Red cell distribution width increased 23.71 10.08 233 1062001 11974 89554239
Paraesthesia ear 23.67 10.08 28 1062206 429 89565784
Needle issue 23.47 10.08 84 1062150 13850 89552363
Graft versus host disease in gastrointestinal tract 23.47 10.08 11 1062223 4377 89561836
Basal cell carcinoma 23.43 10.08 264 1061970 33125 89533088
Skin toxicity 23.31 10.08 27 1062207 6752 89559461
Product administration interrupted 23.31 10.08 72 1062162 12420 89553793
Bacterial test 23.20 10.08 45 1062189 1088 89565125
Bacterial test positive 23.14 10.08 127 1062107 5412 89560801
Immunosuppressant drug level increased 23.14 10.08 13 1062221 4667 89561546
Meniscus injury 23.11 10.08 38 1062196 8199 89558014
Osteopenia 23.10 10.08 166 1062068 22836 89543377
Galactorrhoea 23.07 10.08 13 1062221 4659 89561554
Blood loss anaemia 23.05 10.08 53 1062181 10087 89556126
Product complaint 23.00 10.08 81 1062153 13419 89552794
Secretion discharge 22.87 10.08 102 1062132 15794 89550419
Human herpesvirus 6 infection 22.81 10.08 6 1062228 3426 89562787
Culture urine positive 22.70 10.08 97 1062137 3728 89562485
Clostridium test positive 22.68 10.08 124 1062110 5277 89560936
Feeling abnormal 22.66 10.08 1670 1060564 165565 89400648
Subdural haematoma 22.64 10.08 109 1062125 16536 89549677
Wrong technique in device usage process 22.60 10.08 21 1062213 5814 89560399
Labelled drug-drug interaction medication error 22.56 10.08 91 1062143 14491 89551722
Uterine cancer 22.53 10.08 18 1062216 5367 89560846
Infusion site discomfort 22.44 10.08 59 1062175 1757 89564456
Staphylococcal infection 22.38 10.08 416 1061818 48023 89518190
Polycystic ovaries 22.31 10.08 20 1062214 5634 89560579
Ventricular fibrillation 22.13 10.08 87 1062147 13957 89552256
Periorbital swelling 22.09 10.08 113 1062121 4685 89561528
Metastases to lymph nodes 22.08 10.08 67 1062167 11622 89554591
Device use issue 21.97 10.08 8 1062226 3705 89562508
Dry eye 21.92 10.08 514 1061720 57417 89508796
Soft tissue disorder 21.87 10.08 104 1062130 4186 89562027
Anosognosia 21.86 10.08 7 1062227 3515 89562698
Ketoacidosis 21.83 10.08 20 1062214 5575 89560638
Lip dry 21.73 10.08 1417 1060817 99538 89466675
Facet joint syndrome 21.72 10.08 1384 1060850 97005 89469208
Lymphoma 21.54 10.08 84 1062150 13507 89552706
BK virus infection 21.52 10.08 13 1062221 4485 89561728
Pulmonary embolism 21.50 10.08 1284 1060950 129536 89436677
Extrapyramidal disorder 21.46 10.08 108 1062126 16195 89550018
Eye irritation 21.42 10.08 275 1061959 33703 89532510
Diastolic dysfunction 21.36 10.08 33 1062201 7300 89558913
Drug screen positive 21.32 10.08 94 1062140 3663 89562550
Spinal fracture 21.10 10.08 161 1062073 21855 89544358
Product residue present 21.10 10.08 12 1062222 4279 89561934
Cardiac failure chronic 21.07 10.08 21 1062213 5625 89560588
Nitrite urine present 21.06 10.08 42 1062192 1037 89565176
Renal papillary necrosis 21.01 10.08 21 1062213 263 89565950
Dizziness 21.00 10.08 6377 1055857 582907 88983306
Groin pain 20.99 10.08 73 1062161 12140 89554073
Angina unstable 20.95 10.08 32 1062202 7111 89559102
Abnormal dreams 20.93 10.08 65 1062169 11192 89555021
Paradoxical drug reaction 20.89 10.08 22 1062212 5744 89560469
Medication overuse headache 20.87 10.08 51 1062183 1450 89564763
Coagulation factor decreased 20.80 10.08 18 1062216 185 89566028
Hypertriglyceridaemia 20.68 10.08 38 1062196 7851 89558362
Impaired work ability 20.63 10.08 137 1062097 19189 89547024
Skin exfoliation 20.59 10.08 622 1061612 67291 89498922
Respiratory disorder 20.54 10.08 943 1061291 63873 89502340
Administration site pain 20.52 10.08 44 1062190 1145 89565068
Myopathy 20.51 10.08 85 1062149 13433 89552780
Pulmonary alveolar haemorrhage 20.51 10.08 24 1062210 5974 89560239
Spinal operation 20.31 10.08 57 1062177 10139 89556074
Low density lipoprotein increased 20.26 10.08 40 1062194 8045 89558168
Nocardiosis 20.20 10.08 3 1062231 2567 89563646
Renal failure neonatal 20.20 10.08 18 1062216 193 89566020
Fixed eruption 20.16 10.08 55 1062179 1675 89564538
Blood pressure systolic decreased 20.03 10.08 181 1062053 9089 89557124
Adrenergic syndrome 20.01 10.08 14 1062220 102 89566111
Treatment failure 19.79 10.08 3194 1059040 300734 89265479
Tremor 19.73 10.08 1536 1060698 151637 89414576
Vomiting 19.73 10.08 9847 1052387 778446 88787767
Catheter site bruise 19.72 10.08 29 1062205 555 89565658
Loss of consciousness 19.71 10.08 1396 1060838 138842 89427371
Brain stem glioma 19.70 10.08 17 1062217 174 89566039
Agranulocytosis 19.66 10.08 290 1061944 34712 89531501
Metabolic disorder 19.56 10.08 36 1062198 7434 89558779
Thyroid cancer 19.56 10.08 27 1062207 6257 89559956
Vein rupture 19.55 10.08 53 1062181 1608 89564605
Flatulence 19.51 10.08 354 1061880 41013 89525200
Intervertebral disc protrusion 19.49 10.08 214 1062020 26982 89539231
Lung neoplasm malignant 19.46 10.08 186 1062048 24087 89542126
Hyperthyroidism 19.45 10.08 130 1062104 18180 89548033
Meningitis aseptic 19.39 10.08 141 1062093 6632 89559581
Administration site bruise 19.38 10.08 26 1062208 455 89565758
Lung adenocarcinoma 19.32 10.08 22 1062212 5543 89560670
Premature rupture of membranes 19.26 10.08 22 1062212 5536 89560677
Tricuspid valve incompetence 19.20 10.08 116 1062118 16615 89549598
Obstructive airways disorder 19.17 10.08 202 1062032 25667 89540546
Emotional distress 19.10 10.08 564 1061670 36098 89530115
Cachexia 19.05 10.08 32 1062202 6846 89559367
Systemic candida 19.03 10.08 18 1062216 4941 89561272
Gastrooesophageal reflux disease 19.01 10.08 1684 1060550 164653 89401560
Urine analysis abnormal 18.75 10.08 115 1062119 5106 89561107
Hallucination, auditory 18.73 10.08 110 1062124 15865 89550348
Malnutrition 18.60 10.08 134 1062100 18424 89547789
Infusion site warmth 18.55 10.08 62 1062172 2116 89564097
Haematoma 18.47 10.08 334 1061900 38714 89527499
Intestinal haemorrhage 18.44 10.08 15 1062219 4432 89561781
Dermatitis allergic 18.41 10.08 123 1062111 17204 89549009
Type 2 diabetes mellitus 18.40 10.08 2684 1059550 200560 89365653
Vitamin K deficiency 18.40 10.08 26 1062208 479 89565734
Concomitant disease aggravated 18.38 10.08 71 1062163 11447 89554766
Squamous cell carcinoma 18.30 10.08 59 1062175 10042 89556171
Rebound effect 18.30 10.08 53 1062181 9331 89556882
Diverticulum intestinal 18.29 10.08 51 1062183 9091 89557122
Gastritis 18.25 10.08 362 1061872 41391 89524822
Oesophageal carcinoma 18.23 10.08 4 1062230 2584 89563629
Coagulation factor X level decreased 18.23 10.08 11 1062223 60 89566153
Eye haemorrhage 18.07 10.08 60 1062174 10120 89556093
Mycobacterium avium complex infection 18.04 10.08 13 1062221 4085 89562128
Pulmonary tuberculosis 18.02 10.08 18 1062216 4816 89561397
Hiatus hernia 18.00 10.08 200 1062034 25161 89541052
Vasoplegia syndrome 17.98 10.08 73 1062161 2741 89563472
Malignant melanoma 17.91 10.08 81 1062153 12495 89553718
Delirium 17.87 10.08 1438 1060796 102921 89463292
Multiple drug therapy 17.87 10.08 142 1062092 6867 89559346
Joint range of motion decreased 17.74 10.08 1833 1060401 133810 89432403
Fibromyalgia 17.74 10.08 2716 1059518 203553 89362660
Hypoacusis 17.71 10.08 225 1062009 27625 89538588
Pre-eclampsia 17.69 10.08 68 1062166 10980 89555233
Occupational exposure to product 17.65 10.08 4 1062230 2527 89563686
Pregnancy with contraceptive device 17.61 10.08 20 1062214 5046 89561167
Body height decreased 17.60 10.08 76 1062158 11873 89554340
Chondropathy 17.46 10.08 4 1062230 2508 89563705
Circulatory collapse 17.44 10.08 197 1062037 24707 89541506
Specific gravity urine increased 17.37 10.08 18 1062216 236 89565977
Deep vein thrombosis 17.31 10.08 887 1061347 90733 89475480
Stress fracture 17.26 10.08 48 1062186 8563 89557650
Vascular rupture 17.26 10.08 54 1062180 1779 89564434
Polyomavirus-associated nephropathy 17.24 10.08 4 1062230 2486 89563727
Leukoencephalopathy 17.20 10.08 19 1062215 4854 89561359
Haemarthrosis 17.16 10.08 13 1062221 3981 89562232
Epstein-Barr virus associated lymphoproliferative disorder 17.10 10.08 5 1062229 2662 89563551
Gastric cancer 17.08 10.08 21 1062213 5115 89561098
Melaena 16.98 10.08 296 1061938 34501 89531712
Nephrotic syndrome 16.98 10.08 38 1062196 7301 89558912
Mast cell activation syndrome 16.93 10.08 49 1062185 1545 89564668
Hepatic cyst 16.89 10.08 32 1062202 6536 89559677
Knee operation 16.80 10.08 35 1062199 6901 89559312
Glycosylated haemoglobin increased 16.77 10.08 110 1062124 15452 89550761
Serum sickness-like reaction 16.76 10.08 27 1062207 561 89565652
Blood prolactin increased 16.73 10.08 11 1062223 3626 89562587
Pain in extremity 16.71 10.08 4867 1057367 445662 89120551
Compartment syndrome 16.63 10.08 73 1062161 2839 89563374
Skin ulcer 16.60 10.08 453 1061781 49622 89516591
Urinary casts 16.60 10.08 32 1062202 770 89565443
Disseminated tuberculosis 16.55 10.08 9 1062225 3290 89562923
Tachypnoea 16.54 10.08 346 1061888 20963 89545250
Bundle branch block left 16.52 10.08 43 1062191 7842 89558371
Arrhythmia 16.46 10.08 374 1061860 41958 89524255
Osmolar gap 16.46 10.08 12 1062222 94 89566119
Electric shock sensation 16.42 10.08 48 1062186 1522 89564691
Dermatitis 16.27 10.08 174 1062060 22046 89544167
Injury associated with device 16.21 10.08 17 1062217 4447 89561766
Haemoglobin decreased 16.19 10.08 1656 1060578 160300 89405913
Premature baby 16.17 10.08 202 1062032 24875 89541338
Foetal growth restriction 16.17 10.08 56 1062178 9324 89556889
Product quality issue 16.15 10.08 762 1061472 78563 89487650
Dysmorphism 16.12 10.08 5 1062229 2563 89563650
Glomerular filtration rate increased 16.11 10.08 57 1062177 2003 89564210
Movement disorder 16.10 10.08 241 1061993 28778 89537435
Left ventricular failure 16.07 10.08 34 1062200 6666 89559547
Bladder cancer 16.06 10.08 27 1062207 5774 89560439
Tuberculosis 16.03 10.08 84 1062150 12465 89553748
Application site pain 16.02 10.08 19 1062215 4701 89561512
Kidney transplant rejection 16.01 10.08 20 1062214 4837 89561376
Potentiating drug interaction 16.00 10.08 26 1062208 5636 89560577
Asthma 15.97 10.08 2543 1059691 239617 89326596
Physical deconditioning 15.92 10.08 60 1062174 2175 89564038
Osteomyelitis 15.89 10.08 230 1062004 27616 89538597
Oropharyngeal pain 15.85 10.08 1562 1060672 113625 89452588
Coagulation factor VII level decreased 15.84 10.08 11 1062223 79 89566134
Specific gravity urine abnormal 15.84 10.08 11 1062223 79 89566134
Gout 15.82 10.08 124 1062110 16735 89549478
Body tinea 15.80 10.08 3 1062231 2145 89564068
Mental disorder 15.74 10.08 275 1061959 32043 89534170
Sputum culture positive 15.65 10.08 60 1062174 2193 89564020
Neoplasm malignant 15.64 10.08 291 1061943 33589 89532624
Tongue biting 15.64 10.08 3 1062231 2130 89564083
Tongue pruritus 15.64 10.08 31 1062203 762 89565451
Ejection fraction decreased 15.63 10.08 215 1062019 26038 89540175
Cystic fibrosis pancreatic 15.53 10.08 9 1062225 45 89566168
Upper respiratory tract infection 15.52 10.08 1725 1060509 126593 89439620
Sensitivity to weather change 15.51 10.08 53 1062181 8861 89557352
Sinus tachycardia 15.50 10.08 441 1061793 28072 89538141
Aplasia pure red cell 15.49 10.08 23 1062211 5171 89561042
Tongue disorder 15.47 10.08 195 1062039 10665 89555548
Amniotic cavity disorder 15.44 10.08 10 1062224 63 89566150
Supraventricular tachycardia 15.40 10.08 120 1062114 16216 89549997
Serum sickness 15.33 10.08 82 1062152 3460 89562753
Head injury 15.31 10.08 265 1061969 30923 89535290
Injection site urticaria 15.31 10.08 136 1062098 17875 89548338
Colon cancer 15.28 10.08 71 1062163 10873 89555340
Poor quality device used 15.26 10.08 4 1062230 2289 89563924
Hypercalcaemia 15.22 10.08 296 1061938 33944 89532269
Bezoar 15.21 10.08 68 1062166 2666 89563547
Product dispensing error 15.21 10.08 83 1062151 12190 89554023
Focal dyscognitive seizures 15.16 10.08 9 1062225 3135 89563078
Perfume sensitivity 15.13 10.08 35 1062199 960 89565253
Tachyarrhythmia 15.11 10.08 25 1062209 5381 89560832
Inflammation 15.06 10.08 2349 1059885 176243 89389970
Enterococcal infection 15.05 10.08 63 1062171 9928 89556285
Intestinal obstruction 15.02 10.08 326 1061908 36805 89529408
Pneumatosis intestinalis 15.01 10.08 11 1062223 3426 89562787
Allergy to immunoglobulin therapy 15.00 10.08 15 1062219 188 89566025
Leukaemia 14.99 10.08 22 1062212 4970 89561243
Rotator cuff syndrome 14.98 10.08 117 1062117 15802 89550411
Mastocytosis 14.95 10.08 34 1062200 922 89565291
Asthenia 14.93 10.08 5830 1056404 527921 89038292
Maternal exposure before pregnancy 14.92 10.08 74 1062160 11139 89555074
Atrial flutter 14.90 10.08 70 1062164 10688 89555525
Breast cancer recurrent 14.88 10.08 26 1062208 5477 89560736
Herpes zoster 14.83 10.08 933 1061301 93711 89472502
Aortic valve incompetence 14.75 10.08 35 1062199 6589 89559624
Intracranial pressure increased 14.72 10.08 133 1062101 6678 89559535
Orthostatic hypotension 14.68 10.08 615 1061619 41212 89525001
Nervous system disorder 14.66 10.08 172 1062062 21421 89544792
Blindness 14.62 10.08 221 1062013 26347 89539866
Nasal necrosis 14.62 10.08 12 1062222 114 89566099
Squamous cell carcinoma of skin 14.57 10.08 42 1062192 7407 89558806
Urticaria thermal 14.55 10.08 24 1062210 509 89565704
Migraine 14.45 10.08 2490 1059744 187902 89378311
Peritonitis bacterial 14.38 10.08 24 1062210 5147 89561066
Injection site discomfort 14.37 10.08 30 1062204 5910 89560303
Skin disorder 14.36 10.08 324 1061910 36382 89529831
Pre-existing condition improved 14.32 10.08 57 1062177 9112 89557101
Erysipelas 14.31 10.08 56 1062178 8996 89557217
Neuroblastoma recurrent 14.28 10.08 14 1062220 171 89566042
Transfusion-related acute lung injury 14.22 10.08 14 1062220 172 89566041
Catheter management 14.21 10.08 9 1062225 3027 89563186
Serotonin syndrome 14.21 10.08 561 1061673 37326 89528887
Hepatic cancer 14.19 10.08 22 1062212 4859 89561354
Device defective 14.16 10.08 12 1062222 3474 89562739
Device failure 14.15 10.08 38 1062196 6859 89559354
Disturbance in attention 14.15 10.08 432 1061802 46677 89519536
Proteinuria 14.14 10.08 190 1062044 23101 89543112
Substance abuse 14.04 10.08 110 1062124 5296 89560917
Vital capacity decreased 13.94 10.08 50 1062184 1769 89564444
Ankle fracture 13.93 10.08 162 1062072 20208 89546005
Mood altered 13.90 10.08 131 1062103 17013 89549200
Coronary arterial stent insertion 13.88 10.08 8 1062226 2832 89563381
Shoulder arthroplasty 13.86 10.08 90 1062144 4076 89562137
Portal hypertension 13.84 10.08 21 1062213 4680 89561533
Diabetic metabolic decompensation 13.84 10.08 3 1062231 1954 89564259
Nausea 13.83 10.08 12422 1049812 1097894 88468319
Metastases to peritoneum 13.81 10.08 17 1062217 4138 89562075
Caesarean section 13.79 10.08 145 1062089 18432 89547781
Affective disorder 13.79 10.08 46 1062188 7747 89558466
Catheterisation cardiac 13.78 10.08 23 1062211 4933 89561280
Systemic lupus erythematosus rash 13.73 10.08 60 1062174 2329 89563884
Ejection fraction abnormal 13.70 10.08 6 1062228 2485 89563728
Infection reactivation 13.66 10.08 3 1062231 1937 89564276
Cells in urine 13.66 10.08 14 1062220 181 89566032
Mood swings 13.63 10.08 166 1062068 20536 89545677
Osteoarthritis 13.62 10.08 2049 1060185 193681 89372532
Infusion site scar 13.56 10.08 25 1062209 581 89565632
Mucosal dryness 13.49 10.08 73 1062161 3094 89563119
Blood creatinine decreased 13.46 10.08 126 1062108 6389 89559824
Mental impairment 13.45 10.08 128 1062106 16592 89549621
Pupil fixed 13.44 10.08 55 1062179 2073 89564140
Bradyarrhythmia 13.42 10.08 6 1062228 2455 89563758
Aortic valve stenosis 13.42 10.08 18 1062216 4222 89561991
Gastrointestinal pain 13.41 10.08 195 1062039 11011 89555202
Pneumonia aspiration 13.41 10.08 371 1061863 40569 89525644
Haematemesis 13.39 10.08 297 1061937 33429 89532784
Sinus node dysfunction 13.37 10.08 27 1062207 5385 89560828
Feeling cold 13.36 10.08 419 1061815 27046 89539167
Nutritional supplementation 13.35 10.08 8 1062226 43 89566170
Hepatitis C 13.34 10.08 29 1062205 5631 89560582
Deep vein thrombosis postoperative 13.33 10.08 983 1061251 69826 89496387
Drug level below therapeutic 13.33 10.08 115 1062119 5699 89560514
Antidepressant drug level above therapeutic 13.29 10.08 22 1062212 468 89565745
Harlequin syndrome 13.28 10.08 15 1062219 218 89565995
Adenovirus infection 13.27 10.08 21 1062213 4601 89561612
Eczema 13.26 10.08 496 1061738 52374 89513839
Accidental exposure to product by child 13.23 10.08 40 1062194 1293 89564920
Withdrawal syndrome 13.22 10.08 185 1062049 22339 89543874
Lumbar vertebral fracture 13.21 10.08 44 1062190 7414 89558799
Retinal haemorrhage 13.21 10.08 30 1062204 5734 89560479
Liver transplant 13.17 10.08 58 1062176 2259 89563954
Vein collapse 13.12 10.08 36 1062198 1100 89565113
Anxiety 13.10 10.08 3943 1058291 305829 89260384
Venoocclusive liver disease 13.08 10.08 32 1062202 5961 89560252
Drug provocation test 13.08 10.08 7 1062227 29 89566184
Oesophagitis 13.06 10.08 134 1062100 17115 89549098
Device related infection 13.02 10.08 218 1062016 25568 89540645
Ventricular arrhythmia 12.97 10.08 91 1062143 4230 89561983
Status epilepticus 12.94 10.08 150 1062084 18724 89547489
Hysterectomy 12.94 10.08 81 1062153 11503 89554710
Candida infection 12.93 10.08 302 1061932 33755 89532458
Acute myeloid leukaemia recurrent 12.93 10.08 4 1062230 2053 89564160
Anaemia macrocytic 12.92 10.08 21 1062213 4551 89561662
Embolism venous 12.91 10.08 14 1062220 3606 89562607
Tendon rupture 12.88 10.08 60 1062174 9183 89557030
Infusion site irritation 12.87 10.08 40 1062194 1313 89564900
Infusion site streaking 12.87 10.08 24 1062210 563 89565650
Injection site haematoma 12.84 10.08 40 1062194 6882 89559331
Granulocytopenia 12.84 10.08 36 1062198 6405 89559808
Laboratory test abnormal 12.77 10.08 383 1061851 41471 89524742
Breast cancer stage IV 12.74 10.08 4 1062230 2034 89564179
Dyslipidaemia 12.72 10.08 68 1062166 10039 89556174
Pathological fracture 12.71 10.08 64 1062170 9596 89556617
Lymphopenia 12.70 10.08 190 1062044 22691 89543522
Monocyte percentage increased 12.70 10.08 37 1062197 1171 89565042
Accidental poisoning 12.70 10.08 32 1062202 928 89565285
Hyperhidrosis 12.69 10.08 1803 1060431 134502 89431711
Goitre 12.63 10.08 39 1062195 6728 89559485
Eosinophil percentage increased 12.59 10.08 33 1062201 981 89565232
Blood creatine increased 12.58 10.08 131 1062103 6836 89559377
Klebsiella infection 12.56 10.08 70 1062164 10227 89555986
Fluid retention 12.52 10.08 876 1061358 87215 89478998
Shock haemorrhagic 12.48 10.08 88 1062146 12157 89554056
Granulocyte count increased 12.47 10.08 43 1062191 1491 89564722
Blood glucose abnormal 12.43 10.08 63 1062171 9429 89556784
Post cholecystectomy syndrome 12.32 10.08 30 1062204 851 89565362
Pneumonitis 12.31 10.08 409 1061825 43761 89522452
Cardiac operation 12.26 10.08 17 1062217 3932 89562281
Self-medication 12.25 10.08 72 1062162 3148 89563065
Urosepsis 12.24 10.08 175 1062059 21057 89545156
Dry throat 12.24 10.08 145 1062089 7815 89558398
Limb mass 12.22 10.08 77 1062157 3451 89562762
Injection site nodule 12.22 10.08 21 1062213 4452 89561761
Blood lactate dehydrogenase increased 12.20 10.08 222 1062012 25710 89540503
Nephrectomy 12.18 10.08 4 1062230 1977 89564236
Stress cardiomyopathy 12.18 10.08 99 1062135 13256 89552957
Diffuse large B-cell lymphoma 12.12 10.08 56 1062178 8589 89557624
Transplant failure 12.07 10.08 4 1062230 1965 89564248
Arteriosclerosis 12.06 10.08 76 1062158 10777 89555436
Ototoxicity 12.02 10.08 4 1062230 1960 89564253
Acute psychosis 12.01 10.08 11 1062223 3067 89563146
Antipsychotic drug level increased 12.00 10.08 16 1062218 3763 89562450
Endocarditis enterococcal 12 10.08 15 1062219 244 89565969
Acidosis 12.00 10.08 213 1062021 12523 89553690
Patent ductus arteriosus 11.98 10.08 22 1062212 4547 89561666
Catheter site pruritus 11.96 10.08 6 1062228 2296 89563917
Long QT syndrome 11.92 10.08 18 1062216 4019 89562194
Band neutrophil percentage increased 11.91 10.08 14 1062220 213 89566000
Abdominal pain upper 11.89 10.08 4207 1058027 328467 89237746
Pregnancy with implant contraceptive 11.87 10.08 16 1062218 3745 89562468
Frostbite 11.86 10.08 14 1062220 214 89565999
Clonus 11.78 10.08 111 1062123 5639 89560574
Hypotonic-hyporesponsive episode 11.76 10.08 6 1062228 22 89566191
Ataxia 11.76 10.08 145 1062089 17897 89548316
Myelocyte count increased 11.72 10.08 19 1062215 397 89565816
Aggression 11.72 10.08 231 1062003 26437 89539776
Cerebral ischaemia 11.71 10.08 44 1062190 7152 89559061
Administration site erythema 11.71 10.08 30 1062204 879 89565334
Lactobacillus infection 11.70 10.08 10 1062224 101 89566112
Post-traumatic stress disorder 11.68 10.08 127 1062107 6701 89559512
Arterial occlusive disease 11.67 10.08 208 1062026 12238 89553975
Eyelid ptosis 11.66 10.08 60 1062174 8946 89557267
Cardiogenic shock 11.66 10.08 209 1062025 24259 89541954
Diplopia 11.65 10.08 252 1061982 28462 89537751
Hepatitis B 11.64 10.08 22 1062212 4497 89561716
Glucose tolerance impaired 11.63 10.08 51 1062183 7934 89558279
Tooth extraction 11.61 10.08 83 1062151 11430 89554783
Blood bilirubin increased 11.60 10.08 622 1061612 42848 89523365
Tuberculin test positive 11.60 10.08 16 1062218 3709 89562504
Vasodilation procedure 11.57 10.08 6 1062228 23 89566190
Anoxia 11.55 10.08 15 1062219 254 89565959
Subacute cutaneous lupus erythematosus 11.55 10.08 15 1062219 3567 89562646
Diverticulitis 11.54 10.08 423 1061811 44764 89521449
Cold urticaria 11.51 10.08 16 1062218 290 89565923
Foreign body sensation in eyes 11.50 10.08 13 1062221 3287 89562926
Acute fatty liver of pregnancy 11.49 10.08 7 1062227 39 89566174
Stab wound 11.44 10.08 9 1062225 80 89566133
Plasma cell myeloma recurrent 11.41 10.08 20 1062214 4208 89562005
Skin lesion 11.38 10.08 342 1061892 37023 89529190
Opsoclonus myoclonus 11.36 10.08 12 1062222 161 89566052
White blood cells urine 11.36 10.08 20 1062214 448 89565765
Creatinine urine decreased 11.35 10.08 16 1062218 294 89565919
Vertigo 11.32 10.08 686 1061548 69125 89497088
Infusion site oedema 11.31 10.08 35 1062199 1146 89565067
Renal cancer 11.28 10.08 34 1062200 5911 89560302
Drug effective for unapproved indication 11.27 10.08 51 1062183 7867 89558346
Gastrointestinal perforation 11.24 10.08 21 1062213 4311 89561902
Peripheral sensory neuropathy 11.22 10.08 63 1062171 9187 89557026
Alpha 1 microglobulin increased 11.21 10.08 7 1062227 41 89566172
Petit mal epilepsy 11.20 10.08 26 1062208 4932 89561281
Allergic reaction to excipient 11.20 10.08 27 1062207 761 89565452
Femoral neck fracture 11.20 10.08 72 1062162 10161 89556052
Autoimmune disorder 11.19 10.08 1045 1061189 75699 89490514
Neoplasm recurrence 11.19 10.08 13 1062221 3246 89562967
Hip surgery 11.18 10.08 20 1062214 4175 89562038
Pharyngeal hypoaesthesia 11.14 10.08 18 1062216 375 89565838
Costovertebral angle tenderness 11.14 10.08 12 1062222 165 89566048
Bradypnoea 11.13 10.08 93 1062141 4565 89561648
Metastases to pleura 11.12 10.08 5 1062229 2039 89564174
Infusion site discolouration 11.11 10.08 33 1062201 1056 89565157
Cytomegalovirus colitis 11.10 10.08 14 1062220 3372 89562841
Hypertension 11.07 10.08 5710 1056524 451822 89114391
Dislocation of vertebra 11.05 10.08 780 1061454 55188 89511025
Nasal ulcer 11.05 10.08 9 1062225 2657 89563556
Gingival hypertrophy 11.04 10.08 6 1062228 2194 89564019
Mouth ulceration 10.94 10.08 371 1061863 39603 89526610
Local anaesthetic systemic toxicity 10.93 10.08 15 1062219 3485 89562728
Agitation 10.92 10.08 921 1061313 66177 89500036
Cystitis 10.89 10.08 916 1061318 65802 89500411
Cardiac pacemaker insertion 10.88 10.08 22 1062212 4385 89561828
Plasmacytoma 10.88 10.08 10 1062224 2783 89563430
Thyroid neoplasm 10.87 10.08 19 1062215 4002 89562211
Administration site irritation 10.84 10.08 8 1062226 64 89566149
Pelvic fracture 10.81 10.08 120 1062114 15099 89551114
Partial seizures 10.80 10.08 46 1062188 7214 89558999
Generalised tonic-clonic seizure 10.74 10.08 319 1061915 34584 89531629
Stoma site cellulitis 10.74 10.08 8 1062226 65 89566148
Cerebellar syndrome 10.74 10.08 18 1062216 3854 89562359
Coordination abnormal 10.71 10.08 327 1061907 21029 89545184
Chronic spontaneous urticaria 10.68 10.08 46 1062188 1774 89564439
Anti-neutrophil cytoplasmic antibody positive vasculitis 10.67 10.08 19 1062215 3974 89562239
Pancreatic steatosis 10.67 10.08 3 1062231 1639 89564574
Embedded device 10.66 10.08 21 1062213 4227 89561986
Actinic keratosis 10.64 10.08 13 1062221 3175 89563038
Endocarditis 10.62 10.08 45 1062189 7068 89559145
Skin irritation 10.58 10.08 105 1062129 13498 89552715
Hepatic cirrhosis 10.53 10.08 620 1061614 62633 89503580
Sedation 10.52 10.08 677 1061557 47494 89518719
Administration site nodule 10.51 10.08 6 1062228 29 89566184
Hypovolaemia 10.51 10.08 94 1062140 12337 89553876
Metastases to skin 10.50 10.08 6 1062228 2134 89564079
Infusion site induration 10.41 10.08 41 1062193 1518 89564695
Complications of transplanted kidney 10.41 10.08 11 1062223 2867 89563346
Lung transplant 10.39 10.08 17 1062217 3675 89562538
Deafness neurosensory 10.39 10.08 43 1062191 6798 89559415
Scleroderma 10.38 10.08 38 1062196 6223 89559990
Analgesic drug level below therapeutic 10.37 10.08 3 1062231 0 89566213
Oocyte harvest 10.37 10.08 3 1062231 0 89566213
Orbital compartment syndrome 10.36 10.08 9 1062225 93 89566120
Gastroenteritis 10.33 10.08 262 1061972 28967 89537246
Dialysis 10.32 10.08 84 1062150 11245 89554968
Cystic fibrosis 10.31 10.08 19 1062215 3922 89562291
Metabolic alkalosis 10.31 10.08 16 1062218 3533 89562680
Gangrene 10.30 10.08 210 1062024 12666 89553547
Acute lymphocytic leukaemia recurrent 10.30 10.08 10 1062224 2711 89563502
Antiphospholipid syndrome 10.29 10.08 7 1062227 2267 89563946
Hallucinations, mixed 10.26 10.08 35 1062199 5854 89560359
Hospice care 10.25 10.08 69 1062165 9635 89556578
Asthma-chronic obstructive pulmonary disease overlap syndrome 10.25 10.08 95 1062139 4804 89561409
Device delivery system issue 10.24 10.08 4 1062230 1774 89564439
Rectal prolapse 10.23 10.08 7 1062227 2260 89563953
Thirst 10.23 10.08 132 1062102 16163 89550050
Infection susceptibility increased 10.21 10.08 19 1062215 3907 89562306
Necrotic lymphadenopathy 10.21 10.08 10 1062224 122 89566091
Haemorrhage intracranial 10.20 10.08 121 1062113 15041 89551172
Oropharyngeal spasm 10.20 10.08 15 1062219 287 89565926
Glutathione decreased 10.20 10.08 6 1062228 31 89566182
Haemorrhagic diathesis 10.20 10.08 32 1062202 5492 89560721
Product label confusion 10.19 10.08 345 1061889 22505 89543708
Eastern Cooperative Oncology Group performance status worsened 10.16 10.08 5 1062229 1934 89564279
Tri-iodothyronine free increased 10.15 10.08 13 1062221 217 89565996
Prothrombin time prolonged 10.14 10.08 166 1062068 9606 89556607
Psychotic symptom 10.14 10.08 7 1062227 2249 89563964
Cardiac tamponade 10.13 10.08 33 1062201 5599 89560614
Neurological examination normal 10.11 10.08 7 1062227 50 89566163
Drug specific antibody present 10.11 10.08 104 1062130 5410 89560803
Gallbladder injury 10.09 10.08 36 1062198 1270 89564943
Breast cancer metastatic 10.09 10.08 121 1062113 15011 89551202
Secondary amyloidosis 10.09 10.08 12 1062222 185 89566028

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 3265.50 10.99 6500 359320 222636 42032879
Completed suicide 2412.23 10.99 3520 362300 92945 42162570
Infusion related reaction 1226.60 10.99 2011 363809 58795 42196720
Exposure to toxic agent 1065.28 10.99 615 365205 4389 42251126
Intentional overdose 789.53 10.99 1510 364310 49946 42205569
Drug abuse 700.60 10.99 2234 363586 102537 42152978
Overdose 687.08 10.99 2226 363594 103038 42152477
Intentional product misuse 587.37 10.99 1498 364322 60402 42195113
Acute hepatic failure 454.78 10.99 643 365177 16430 42239085
Blood pressure fluctuation 451.71 10.99 821 364999 26087 42229428
Drug ineffective 395.80 10.99 3488 362332 626709 41628806
Urticaria 334.22 10.99 1390 364430 72646 42182869
Heart rate decreased 270.73 10.99 808 365012 35724 42219791
Cytokine release syndrome 256.85 10.99 904 364916 43623 42211892
Chills 256.77 10.99 1531 364289 92535 42162980
Hepatic cytolysis 250.65 10.99 646 365174 26198 42229317
Suicide attempt 249.80 10.99 917 364903 45183 42210332
Flushing 249.30 10.99 792 365028 36236 42219279
Blood pressure increased 246.98 10.99 1609 364211 100319 42155196
Blood pressure systolic increased 217.16 10.99 629 365191 27339 42228176
Suspected suicide 210.54 10.99 263 365557 5936 42249579
Metabolic acidosis 202.21 10.99 932 364888 50926 42204589
Oxygen saturation decreased 198.20 10.99 1086 364734 63601 42191914
Respiratory arrest 193.18 10.99 610 365210 27814 42227701
Analgesic drug level increased 188.69 10.99 118 365702 990 42254525
Drug resistance 184.56 10.99 35 365785 34213 42221302
Cardio-respiratory arrest 178.01 10.99 982 364838 57654 42197861
Accidental overdose 177.20 10.99 591 365229 27739 42227776
Blood pressure diastolic abnormal 176.96 10.99 240 365580 5888 42249627
Myocardial infarction 170.15 10.99 523 365297 123486 42132029
Poisoning deliberate 156.00 10.99 298 365522 9836 42245679
Poisoning 151.12 10.99 367 365453 14332 42241183
Myelosuppression 149.93 10.99 80 365740 40381 42215134
Cardiac failure 148.47 10.99 448 365372 106408 42149107
Cardiac failure congestive 142.43 10.99 328 365492 85274 42170241
Intentional product use issue 141.15 10.99 1078 364742 70755 42184760
Anaphylactic reaction 138.64 10.99 729 365091 42014 42213501
Pyroglutamic acidosis 137.22 10.99 85 365735 700 42254815
Diarrhoea 132.92 10.99 2980 362840 457869 41797646
Respiratory depression 130.10 10.99 407 365413 18461 42237054
Febrile neutropenia 126.84 10.99 2269 363551 183434 42072081
Blood pressure systolic abnormal 126.68 10.99 194 365626 5334 42250181
Throat irritation 125.07 10.99 317 365503 12719 42242796
Medication error 122.72 10.99 587 365233 32567 42222948
Heart rate increased 122.41 10.99 830 364990 52425 42203090
Therapeutic product effect incomplete 117.85 10.99 272 365548 70667 42184848
Product dose omission issue 116.70 10.99 810 365010 153555 42101960
Anion gap 113.17 10.99 77 365743 756 42254759
Exposure via ingestion 109.66 10.99 112 365708 2010 42253505
Injection site pain 108.27 10.99 207 365613 57591 42197924
Renal impairment 105.76 10.99 536 365284 109692 42145823
Tachycardia 102.65 10.99 1322 364498 99765 42155750
Suspected suicide attempt 94.87 10.99 52 365768 331 42255184
Malignant neoplasm progression 90.94 10.99 551 365269 107849 42147666
Blood pressure diastolic increased 90.88 10.99 182 365638 6223 42249292
Unresponsive to stimuli 88.72 10.99 516 365304 30887 42224628
Coagulopathy 86.85 10.99 399 365421 21763 42233752
Disease progression 85.46 10.99 804 365016 142852 42112663
Infusion site extravasation 85.38 10.99 162 365658 5319 42250196
Treatment failure 84.49 10.99 266 365554 62358 42193157
Cardiac arrest 84.08 10.99 1362 364458 107958 42147557
Liver injury 82.03 10.99 354 365466 18794 42236721
Anaemia 81.77 10.99 1808 364012 278470 41977045
Drug interaction 80.29 10.99 1714 364106 265285 41990230
Inspiratory capacity decreased 79.37 10.99 112 365708 2855 42252660
Body temperature increased 78.66 10.99 365 365455 19993 42235522
Interstitial lung disease 77.26 10.99 378 365442 78084 42177431
Fixed eruption 76.84 10.99 100 365720 2354 42253161
Blood pressure diastolic decreased 76.38 10.99 229 365591 10146 42245369
Poor venous access 71.29 10.99 178 365642 7074 42248441
Throat tightness 70.78 10.99 212 365608 9387 42246128
Sinusitis 70.28 10.99 667 365153 46625 42208890
Vomiting 70.16 10.99 3098 362722 286625 41968890
Erythema 69.86 10.99 1317 364503 107476 42148039
Wrong technique in product usage process 68.77 10.99 166 365654 42469 42213046
Body temperature decreased 67.63 10.99 274 365546 14139 42241376
Inappropriate schedule of product administration 66.49 10.99 1175 364645 94727 42160788
Pancytopenia 65.37 10.99 670 365150 117073 42138442
Hypotension 64.60 10.99 2765 363055 254866 42000649
Infusion site pain 63.44 10.99 142 365678 5253 42250262
Pharyngeal paraesthesia 62.18 10.99 56 365764 853 42254662
Hepatitis fulminant 59.97 10.99 132 365688 4827 42250688
Hospitalisation 59.63 10.99 383 365437 73947 42181568
Prostate cancer 59.25 10.99 191 365629 44452 42211063
Infusion site erythema 58.84 10.99 109 365711 3513 42252002
Heart rate irregular 57.10 10.99 281 365539 15769 42239746
Sleep disorder due to a general medical condition 57.00 10.99 40 365780 17413 42238102
Drug hypersensitivity 54.75 10.99 1176 364644 98213 42157302
Infusion site swelling 54.65 10.99 100 365720 3192 42252323
Environmental exposure 54.44 10.99 32 365788 237 42255278
Coma 53.32 10.99 698 365122 52856 42202659
Generalised bullous fixed drug eruption 52.97 10.99 38 365782 409 42255106
Osteonecrosis of jaw 51.95 10.99 52 365768 18997 42236518
Labelled drug-drug interaction medication error 51.84 10.99 35 365785 15547 42239968
Atrial fibrillation 50.83 10.99 867 364953 138726 42116789
Bone marrow failure 50.15 10.99 133 365687 32960 42222555
Respiratory rate increased 50.08 10.99 208 365612 10854 42244661
Bladder cancer 49.46 10.99 44 365776 17003 42238512
Cerebral haemorrhage 49.45 10.99 170 365650 38796 42216719
Cardiac failure chronic 49.26 10.99 11 365809 9590 42245925
Cerebral infarction 48.98 10.99 123 365697 31046 42224469
Fall 48.39 10.99 1589 364231 232931 42022584
Pulmonary alveolar haemorrhage 48.33 10.99 34 365786 14782 42240733
Hepatotoxicity 47.90 10.99 375 365445 24792 42230723
Methaemoglobinaemia 47.87 10.99 133 365687 5641 42249874
Post transplant lymphoproliferative disorder 47.71 10.99 10 365810 9110 42246405
Graft versus host disease 47.22 10.99 26 365794 12899 42242616
Coronary artery disease 46.64 10.99 270 365550 53450 42202065
Haematotoxicity 46.49 10.99 18 365802 10967 42244548
Obstructive airways disorder 46.07 10.99 89 365731 24670 42230845
Pneumonia 45.84 10.99 3065 362755 419084 41836431
Asthenia 45.61 10.99 1958 363862 278835 41976680
Accidental death 45.42 10.99 89 365731 2994 42252521
Infusion site pruritus 45.10 10.99 53 365767 1120 42254395
Aplastic anaemia 44.90 10.99 218 365602 12166 42243349
Vanishing bile duct syndrome 44.77 10.99 67 365753 1804 42253711
Hepatitis acute 44.01 10.99 173 365647 8802 42246713
Cerebrovascular accident 43.77 10.99 579 365241 96581 42158934
Pathogen resistance 43.36 10.99 22 365798 11428 42244087
Depressed level of consciousness 43.16 10.99 614 365206 47356 42208159
Decreased appetite 43.12 10.99 1295 364525 191842 42063673
Renal cortical necrosis 43.11 10.99 25 365795 180 42255335
Forced expiratory volume decreased 42.84 10.99 7 365813 7623 42247892
Multiple-drug resistance 42.76 10.99 6 365814 7316 42248199
Therapeutic product effect decreased 42.46 10.99 182 365638 38968 42216547
Neuropathy peripheral 42.31 10.99 617 365203 101236 42154279
Pulmonary vasculitis 42.13 10.99 3 365817 6263 42249252
Glycosylated haemoglobin increased 41.71 10.99 30 365790 12894 42242621
Prothrombin time ratio decreased 41.70 10.99 37 365783 552 42254963
Cytomegalovirus infection 41.63 10.99 140 365680 32166 42223349
Toxic epidermal necrolysis 41.60 10.99 381 365439 26369 42229146
Pemphigus 41.26 10.99 67 365753 1939 42253576
Somnolence 41.24 10.99 1540 364280 139565 42115950
Therapy partial responder 40.82 10.99 68 365752 19953 42235562
Pruritus 40.54 10.99 1995 363825 186776 42068739
Feeling hot 39.89 10.99 341 365479 23141 42232374
Progressive multifocal leukoencephalopathy 39.61 10.99 25 365795 11511 42244004
General physical health deterioration 39.46 10.99 992 364828 150254 42105261
Oesophageal carcinoma 39.23 10.99 17 365803 9679 42245836
Alanine aminotransferase increased 38.87 10.99 1014 364806 87392 42168123
Full blood count abnormal 38.82 10.99 129 365691 29747 42225768
Erectile dysfunction 38.61 10.99 99 365721 24814 42230701
Hypersensitivity 37.52 10.99 849 364971 71521 42183994
Aspartate aminotransferase increased 37.47 10.99 897 364923 76266 42179249
Hepatic necrosis 37.37 10.99 95 365725 3818 42251697
Oedema peripheral 37.27 10.99 886 364934 135190 42120325
Myopathy 37.03 10.99 38 365782 13723 42241792
Lymphocyte count abnormal 37.02 10.99 67 365753 2120 42253395
Therapy cessation 36.77 10.99 75 365745 20375 42235140
Stevens-Johnson syndrome 36.60 10.99 320 365500 21858 42233657
Cholestatic liver injury 36.42 10.99 91 365729 3618 42251897
Drug dose omission by device 36.38 10.99 4 365816 5882 42249633
BK virus infection 36.18 10.99 15 365805 8769 42246746
Hyperhidrosis 36.06 10.99 1025 364795 89487 42166028
Sopor 36.04 10.99 36 365784 13166 42242349
Infusion site rash 35.97 10.99 36 365784 630 42254885
Mydriasis 35.93 10.99 160 365660 8610 42246905
Asthma 35.63 10.99 352 365468 61962 42193553
Therapy interrupted 35.59 10.99 87 365733 22163 42233352
Depression 35.42 10.99 708 365112 110655 42144860
Body temperature fluctuation 35.23 10.99 56 365764 1591 42253924
Syringe issue 34.62 10.99 15 365805 8541 42246974
Syncope 34.37 10.99 623 365197 98783 42156732
Acute myocardial infarction 34.34 10.99 326 365494 57839 42197676
Prostatic specific antigen increased 34.03 10.99 58 365762 16867 42238648
Gastrointestinal haemorrhage 33.94 10.99 612 365208 97114 42158401
Visual acuity reduced 33.61 10.99 62 365758 17488 42238027
Postmortem blood drug level increased 33.50 10.99 31 365789 490 42255025
Immune reconstitution inflammatory syndrome 33.45 10.99 23 365797 10120 42245395
Memory impairment 33.39 10.99 273 365547 49949 42205566
Epilepsy 33.32 10.99 114 365706 26057 42229458
COVID-19 33.28 10.99 1263 364557 114685 42140830
Lymphocyte percentage decreased 33.02 10.99 65 365755 2194 42253321
Neutrophil percentage increased 33.01 10.99 60 365760 1905 42253610
Transplant rejection 32.77 10.99 41 365779 13547 42241968
Mite allergy 32.30 10.99 3 365817 5043 42250472
Lung neoplasm malignant 32.11 10.99 73 365747 19074 42236441
Acute myeloid leukaemia 31.82 10.99 92 365728 22164 42233351
Chronic gastrointestinal bleeding 31.68 10.99 25 365795 314 42255201
Sinus tachycardia 31.52 10.99 293 365527 20360 42235155
Dyspnoea exertional 31.37 10.99 277 365543 49871 42205644
Ear pruritus 31.20 10.99 35 365785 702 42254813
Accident 30.80 10.99 124 365696 6379 42249136
Tongue disorder 30.76 10.99 109 365711 5274 42250241
Cytopenia 30.75 10.99 65 365755 17432 42238083
Chronic graft versus host disease 30.72 10.99 7 365813 6018 42249497
Abdominal pain 30.72 10.99 1961 363859 188510 42067005
Drug ineffective for unapproved indication 30.66 10.99 251 365569 45912 42209603
Device leakage 30.50 10.99 26 365794 10259 42245256
Acidosis 30.39 10.99 195 365625 12084 42243431
Septic shock 30.30 10.99 579 365241 91093 42164422
Aspergillus infection 30.28 10.99 56 365764 15781 42239734
Clostridium test positive 30.21 10.99 110 365710 5395 42250120
Pulmonary fibrosis 30.19 10.99 122 365698 26559 42228956
Incorrect drug administration rate 30.19 10.99 61 365759 2099 42253416
Agitation 30.13 10.99 744 365076 63570 42191945
Adulterated product 30.10 10.99 35 365785 731 42254784
Acute graft versus host disease in skin 30.06 10.99 13 365807 7411 42248104
Renal failure 30.03 10.99 972 364848 142754 42112761
Delusion of grandeur 29.87 10.99 58 365762 1938 42253577
Head discomfort 29.73 10.99 105 365715 5072 42250443
Immune effector cell-associated neurotoxicity syndrome 29.73 10.99 160 365660 9301 42246214
Ear infection 29.66 10.99 200 365620 12604 42242911
Substance abuse 29.63 10.99 153 365667 8752 42246763
Mixed liver injury 29.46 10.99 95 365725 4379 42251136
Hypothyroidism 29.07 10.99 159 365661 31925 42223590
Ductus arteriosus premature closure 28.97 10.99 21 365799 230 42255285
Renal disorder 28.87 10.99 139 365681 28841 42226674
Injection site bruising 28.62 10.99 34 365786 11491 42244024
Nocardiosis 28.61 10.99 5 365815 5185 42250330
Infusion site bruising 28.58 10.99 38 365782 914 42254601
Hypoxia 28.55 10.99 793 365027 68993 42186522
Angina pectoris 28.20 10.99 166 365654 32730 42222785
Intraocular pressure increased 28.13 10.99 10 365810 6423 42249092
Rhinalgia 28.10 10.99 54 365766 1790 42253725
Diabetic ketoacidosis 28.09 10.99 98 365722 22269 42233246
Psoriasis 28.02 10.99 274 365546 48330 42207185
Conjunctivitis allergic 27.96 10.99 8 365812 5903 42249612
Myelodysplastic syndrome 27.67 10.99 101 365719 22644 42232871
Dust allergy 27.58 10.99 6 365814 5326 42250189
Leukopenia 26.93 10.99 465 365355 74281 42181234
Acute kidney injury 26.86 10.99 2752 363068 364585 41890930
Thrombotic microangiopathy 26.75 10.99 54 365766 14728 42240787
Injection site haemorrhage 26.68 10.99 37 365783 11699 42243816
Serum sickness 26.65 10.99 59 365761 2166 42253349
Medication overuse headache 26.45 10.99 19 365801 205 42255310
Hyperkalaemia 26.34 10.99 509 365311 79949 42175566
Product substitution issue 26.27 10.99 35 365785 11255 42244260
Graft versus host disease in gastrointestinal tract 26.17 10.99 6 365814 5137 42250378
Cerebral artery thrombosis 26.07 10.99 42 365778 1207 42254308
Pallor 25.68 10.99 369 365451 28517 42226998
Pyrexia 25.53 10.99 3804 362016 390238 41865277
Enterocolitis infectious 25.37 10.99 54 365766 1929 42253586
Cytomegalovirus viraemia 25.35 10.99 31 365789 10346 42245169
Acute graft versus host disease 25.31 10.99 20 365800 8195 42247320
Second primary malignancy 25.13 10.99 27 365793 9548 42245967
Hepatitis C 25.05 10.99 30 365790 10103 42245412
Sedation 25.03 10.99 384 365436 30091 42225424
Tuberculosis 24.85 10.99 30 365790 10069 42245446
Polyneuropathy 24.64 10.99 80 365740 18581 42236934
Diabetes mellitus 24.59 10.99 365 365455 59722 42195793
Cardiac disorder 24.51 10.99 285 365535 48647 42206868
Bronchopulmonary aspergillosis 24.49 10.99 85 365735 19344 42236171
Headache 24.37 10.99 2378 363442 236991 42018524
Blood pH decreased 24.29 10.99 58 365762 2240 42253275
Asphyxia 24.28 10.99 138 365682 8188 42247327
Neurological symptom 24.25 10.99 30 365790 9961 42245554
Infusion site urticaria 24.24 10.99 17 365803 176 42255339
Renal papillary necrosis 24.12 10.99 16 365804 150 42255365
Myocardial fibrosis 24.10 10.99 41 365779 1234 42254281
Myalgia 24.02 10.99 634 365186 95446 42160069
Thrombocytopenia 23.97 10.99 1362 364458 188917 42066598
Hepatocellular carcinoma 23.95 10.99 21 365799 8173 42247342
Monocyte chemotactic protein-1 increased 23.86 10.99 22 365798 346 42255169
Ejection fraction decreased 23.75 10.99 103 365717 21984 42233531
Cystitis haemorrhagic 23.67 10.99 17 365803 7312 42248203
Patient uncooperative 23.64 10.99 29 365791 642 42254873
Alpha tumour necrosis factor increased 23.61 10.99 22 365798 351 42255164
Blood glucose increased 23.59 10.99 468 365352 73231 42182284
Foetal exposure during pregnancy 23.52 10.99 276 365544 47035 42208480
Victim of child abuse 23.49 10.99 39 365781 1150 42254365
Pulse absent 23.39 10.99 112 365708 6215 42249300
Therapy non-responder 23.29 10.99 320 365500 53039 42202476
Appendicolith 23.17 10.99 196 365624 13260 42242255
Haemoptysis 23.08 10.99 269 365551 45898 42209617
Low birth weight baby 23.02 10.99 31 365789 9924 42245591
Systemic infection 22.92 10.99 8 365812 5197 42250318
Rebound effect 22.69 10.99 18 365802 7361 42248154
Hepatic function abnormal 22.59 10.99 309 365511 51258 42204257
Pulmonary oedema 22.53 10.99 608 365212 52664 42202851
Anion gap abnormal 22.46 10.99 23 365797 414 42255101
Dehydration 22.45 10.99 991 364829 140776 42114739
Product use in unapproved indication 22.39 10.99 1325 364495 183131 42072384
Osteonecrosis 22.38 10.99 66 365754 15799 42239716
Infusion site discomfort 22.21 10.99 22 365798 380 42255135
Blood creatine phosphokinase increased 22.14 10.99 287 365533 48051 42207464
Oropharyngeal pain 22.12 10.99 499 365321 42011 42213504
Melaena 22.09 10.99 219 365601 38527 42216988
Circulatory collapse 22.04 10.99 116 365704 23520 42231995
Dizziness 21.97 10.99 1841 363979 247413 42008102
Infusion site reaction 21.88 10.99 40 365780 1276 42254239
Neuroblastoma recurrent 21.75 10.99 22 365798 390 42255125
Urine sodium decreased 21.65 10.99 15 365805 152 42255363
Parvimonas micra infection 21.58 10.99 11 365809 59 42255456
Psychiatric decompensation 21.34 10.99 5 365815 4217 42251298
Pulmonary arterial hypertension 21.33 10.99 34 365786 10153 42245362
Nightmare 21.25 10.99 317 365503 24695 42230820
Inadequate analgesia 21.15 10.99 68 365752 3129 42252386
Normochromic normocytic anaemia 21.01 10.99 28 365792 9003 42246512
Disturbance in attention 20.94 10.99 160 365660 29706 42225809
Blood immunoglobulin G decreased 20.88 10.99 55 365765 2259 42253256
Lymphocyte count decreased 20.80 10.99 345 365475 27464 42228051
Diffuse large B-cell lymphoma recurrent 20.68 10.99 8 365812 4878 42250637
Stomatitis 20.49 10.99 306 365514 50023 42205492
Cytomegalovirus chorioretinitis 20.45 10.99 7 365813 4604 42250911
Self-medication 20.29 10.99 68 365752 3198 42252317
Feeling cold 20.28 10.99 185 365635 12788 42242727
Injection site swelling 20.24 10.99 76 365744 16897 42238618
Plasma cell myeloma 20.17 10.99 287 365533 47291 42208224
Fluid replacement 20.14 10.99 19 365801 308 42255207
Transplant failure 20.02 10.99 5 365815 4039 42251476
Epstein-Barr virus infection 19.81 10.99 33 365787 9685 42245830
Drug screen positive 19.75 10.99 79 365741 4052 42251463
Lip swelling 19.66 10.99 250 365570 18803 42236712
Hyperaesthesia 19.62 10.99 102 365718 5850 42249665
Apparent death 19.53 10.99 4 365816 3704 42251811
Granulomatosis with polyangiitis 19.52 10.99 41 365779 1451 42254064
Pharyngeal swelling 19.48 10.99 69 365751 3338 42252177
Chest discomfort 19.46 10.99 698 365122 62918 42192597
Back pain 19.38 10.99 1440 364380 140336 42115179
Visual impairment 19.37 10.99 257 365563 42856 42212659
Palmar-plantar erythrodysaesthesia syndrome 19.20 10.99 101 365719 20481 42235034
Venoocclusive liver disease 19.19 10.99 37 365783 10265 42245250
Gait inability 19.15 10.99 116 365704 22717 42232798
Neutropenia 19.10 10.99 1463 364357 197968 42057547
Mental status changes 19.07 10.99 485 365335 41630 42213885
Immunosuppressant drug level increased 18.99 10.99 23 365797 7708 42247807
Lung disorder 18.96 10.99 293 365527 47630 42207885
Migraine 18.90 10.99 315 365505 25099 42230416
Acute lung injury 18.88 10.99 42 365778 1547 42253968
Pupil fixed 18.79 10.99 47 365773 1870 42253645
Drug level below therapeutic 18.77 10.99 108 365712 6437 42249078
Tenosynovitis 18.74 10.99 85 365735 4610 42250905
Monocyte percentage increased 18.73 10.99 33 365787 1022 42254493
Dysmorphism 18.71 10.99 3 365817 3313 42252202
Drug specific antibody present 18.67 10.99 76 365744 3930 42251585
Child abuse 18.63 10.99 30 365790 862 42254653
Infusion site nodule 18.59 10.99 12 365808 107 42255408
Physical deconditioning 18.57 10.99 54 365766 2351 42253164
Brain scan abnormal 18.54 10.99 36 365784 1203 42254312
Nodal rhythm 18.39 10.99 42 365778 1575 42253940
Underdose 18.36 10.99 77 365743 16589 42238926
Chronic kidney disease 18.29 10.99 290 365530 46951 42208564
Peripheral swelling 18.25 10.99 613 365207 89657 42165858
Neoplasm progression 18.21 10.99 160 365660 28840 42226675
Hepatic failure 18.21 10.99 442 365378 37658 42217857
Postoperative delirium 18.09 10.99 24 365796 576 42254939
Sexual dysfunction 17.90 10.99 19 365801 6756 42248759
Symmetrical drug-related intertriginous and flexural exanthema 17.86 10.99 29 365791 839 42254676
Retinal haemorrhage 17.84 10.99 14 365806 5756 42249759
Anticholinergic syndrome 17.77 10.99 41 365779 1548 42253967
Unintentional medical device removal 17.76 10.99 3 365817 3188 42252327
Premature baby 17.70 10.99 121 365699 23032 42232483
Haematuria 17.61 10.99 370 365450 57429 42198086
Posterior reversible encephalopathy syndrome 17.61 10.99 54 365766 12767 42242748
Lipodystrophy acquired 17.61 10.99 4 365816 3446 42252069
Therapeutic response decreased 17.60 10.99 218 365602 36794 42218721
Gastric cancer 17.53 10.99 20 365800 6883 42248632
Epidural lipomatosis 17.50 10.99 44 365776 1756 42253759
Haemorrhage 17.49 10.99 391 365429 60172 42195343
Full blood count decreased 17.49 10.99 104 365716 20456 42235059
Pemphigoid 17.44 10.99 46 365774 11421 42244094
Hereditary angioedema 17.43 10.99 39 365781 1442 42254073
Pulmonary sequestration 17.41 10.99 9 365811 50 42255465
Swollen tongue 17.23 10.99 267 365553 20964 42234551
Cyanosis 17.14 10.99 201 365619 14830 42240685
Nodule 17.06 10.99 53 365767 12481 42243034
Urine abnormality 17.03 10.99 50 365770 2189 42253326
Reversible cerebral vasoconstriction syndrome 17.00 10.99 26 365794 714 42254801
Cardiac failure acute 16.94 10.99 60 365760 13573 42241942
Aplasia pure red cell 16.89 10.99 22 365798 7144 42248371
Cytomegalovirus infection reactivation 16.88 10.99 45 365775 11133 42244382
Interleukin level increased 16.85 10.99 29 365791 881 42254634
Drug-induced liver injury 16.81 10.99 439 365381 37834 42217681
Enthesopathy 16.80 10.99 84 365736 4744 42250771
Adenocarcinoma of colon 16.79 10.99 6 365814 3841 42251674
Sudden infant death syndrome 16.74 10.99 17 365803 303 42255212
Tooth infection 16.72 10.99 122 365698 7889 42247626
Anaphylactoid reaction 16.70 10.99 60 365760 2923 42252592
Injection site mass 16.68 10.99 30 365790 8545 42246970
Hypertriglyceridaemia 16.66 10.99 39 365781 10087 42245428
Nocturia 16.64 10.99 51 365769 12061 42243454
Mononeuropathy 16.59 10.99 16 365804 267 42255248
Adverse event 16.41 10.99 127 365693 23513 42232002
Crystal urine present 16.40 10.99 20 365800 440 42255075
Nasal septum perforation 16.31 10.99 15 365805 235 42255280
Viral load increased 16.28 10.99 3 365817 2994 42252521
Accidental poisoning 16.24 10.99 35 365785 1261 42254254
SARS-CoV-2 test positive 16.22 10.99 124 365696 8136 42247379
Specific gravity urine increased 16.17 10.99 13 365807 168 42255347
Deep vein thrombosis 16.17 10.99 520 365300 76437 42179078
Cytomegalovirus colitis 16.07 10.99 7 365813 3974 42251541
Pulmonary congestion 16.06 10.99 206 365614 15524 42239991
Candida infection 16.00 10.99 114 365706 21496 42234019
Tooth injury 15.93 10.99 34 365786 1217 42254298
Parkinsonism 15.86 10.99 43 365777 10580 42244935
Metastases to liver 15.86 10.99 79 365741 16247 42239268
Leukocytosis 15.85 10.99 350 365470 29358 42226157
Crohn's disease 15.85 10.99 59 365761 2925 42252590
Anti-erythrocyte antibody positive 15.83 10.99 8 365812 42 42255473
Respiratory symptom 15.81 10.99 46 365774 11060 42244455
Pneumocystis jirovecii pneumonia 15.78 10.99 139 365681 25042 42230473
Vision blurred 15.71 10.99 346 365474 53353 42202162
Brain injury 15.65 10.99 116 365704 7539 42247976
Surgery 15.57 10.99 88 365732 17528 42237987
Oral pruritus 15.55 10.99 21 365799 513 42255002
Hepatic cirrhosis 15.54 10.99 102 365718 19600 42235915
Vital functions abnormal 15.52 10.99 18 365802 375 42255140
Antemortem blood drug level abnormal 15.50 10.99 9 365811 65 42255450
Specific gravity urine decreased 15.50 10.99 9 365811 65 42255450
Kidney transplant rejection 15.48 10.99 32 365788 8651 42246864
Bezoar 15.47 10.99 34 365786 1242 42254273
Skin exfoliation 15.45 10.99 257 365563 41296 42214219
Dry skin 15.45 10.99 307 365513 48031 42207484
Hallucination, tactile 15.44 10.99 22 365798 566 42254949
Arthropod sting 15.42 10.99 20 365800 469 42255046
Ureteric haemorrhage 15.30 10.99 14 365806 218 42255297
Radial pulse abnormal 15.25 10.99 8 365812 46 42255469
Blood pressure decreased 15.22 10.99 629 365191 57703 42197812
Administration site pruritus 15.21 10.99 6 365814 15 42255500
Acute phase reaction 15.19 10.99 12 365808 151 42255364
Right ventricle outflow tract obstruction 15.11 10.99 8 365812 47 42255468
Acid-base balance disorder mixed 15.11 10.99 8 365812 47 42255468
Gait disturbance 15.11 10.99 687 365133 97313 42158202
Oxygen saturation abnormal 14.98 10.99 44 365776 1927 42253588
Exposure via inhalation 14.97 10.99 7 365813 30 42255485
Drug withdrawal syndrome neonatal 14.86 10.99 10 365810 4451 42251064
Consciousness fluctuating 14.78 10.99 34 365786 1281 42254234
Injection site reaction 14.74 10.99 77 365743 15644 42239871
Hemiparesis 14.72 10.99 88 365732 17288 42238227
Coronary arterial stent insertion 14.58 10.99 8 365812 3977 42251538
Arthropathy 14.58 10.99 173 365647 29424 42226091
Gastrointestinal toxicity 14.54 10.99 8 365812 3971 42251544
Analgesic drug level above therapeutic 14.50 10.99 16 365804 315 42255200
Graft versus host disease in skin 14.47 10.99 14 365806 5198 42250317
Wrong technique in device usage process 14.47 10.99 3 365817 2754 42252761
Dyspnoea 14.46 10.99 3474 362346 439147 41816368
Incorrect dose administered by device 14.46 10.99 3 365817 2753 42252762
Appendicitis 14.42 10.99 253 365567 20360 42235155
Acute coronary syndrome 14.40 10.99 72 365748 14793 42240722
Acute graft versus host disease in intestine 14.36 10.99 8 365812 3943 42251572
JC virus infection 14.33 10.99 4 365816 3000 42252515
Platelet count decreased 14.32 10.99 1010 364810 137571 42117944
Depressed mood 14.25 10.99 130 365690 23254 42232261
Bilirubin urine present 14.14 10.99 12 365808 168 42255347
Complications of transplanted kidney 14.14 10.99 15 365805 5335 42250180
Sulphaemoglobinaemia 14.12 10.99 7 365813 35 42255480
Renal cancer 14.08 10.99 31 365789 8193 42247322
Cryptococcosis 14.03 10.99 5 365815 3206 42252309
Treatment noncompliance 14.01 10.99 233 365587 37439 42218076
Hyperphosphataemia 14 10.99 172 365648 12832 42242683
Antipsychotic drug level below therapeutic 13.98 10.99 5 365815 3199 42252316
Accidental exposure to product by child 13.89 10.99 37 365783 1530 42253985
Type 2 diabetes mellitus 13.89 10.99 97 365723 18374 42237141
Product storage error 13.86 10.99 49 365771 11091 42244424
Delirium 13.86 10.99 567 365253 51952 42203563
Angina unstable 13.82 10.99 51 365769 11397 42244118
Weight fluctuation 13.81 10.99 93 365727 5858 42249657
Mechanical ventilation complication 13.79 10.99 23 365797 681 42254834
White blood cells urine positive 13.78 10.99 35 365785 1406 42254109
Aminoaciduria 13.76 10.99 14 365806 250 42255265
Disease recurrence 13.67 10.99 176 365644 29502 42226013
Prothrombin time abnormal 13.63 10.99 26 365794 857 42254658
Blood phosphorus increased 13.63 10.99 166 365654 12359 42243156
Substance-induced psychotic disorder 13.61 10.99 55 365765 2834 42252681
Proteinuria 13.48 10.99 129 365691 22854 42232661
Prostatic pain 13.44 10.99 16 365804 343 42255172
Ischaemic cardiomyopathy 13.43 10.99 22 365798 6500 42249015
Ductus arteriosus stenosis foetal 13.42 10.99 12 365808 181 42255334
Pyroglutamate increased 13.41 10.99 15 365805 300 42255215
Nasopharyngitis 13.37 10.99 864 364956 83132 42172383
Increased appetite 13.34 10.99 36 365784 8870 42246645
Leukaemia 13.32 10.99 18 365802 5754 42249761
Therapeutic product effect variable 13.31 10.99 5 365815 3104 42252411
Right ventricular failure 13.29 10.99 40 365780 9515 42246000
Infusion site haemorrhage 13.25 10.99 32 365788 1245 42254270
Peripheral arterial occlusive disease 13.23 10.99 24 365796 6814 42248701
Bone erosion 13.22 10.99 11 365809 4392 42251123
Carotid artery occlusion 13.19 10.99 10 365810 4184 42251331
Device difficult to use 13.17 10.99 12 365808 4584 42250931
Actinic keratosis 13.14 10.99 15 365805 5161 42250354
Foreign body aspiration 13.14 10.99 15 365805 307 42255208
Neuroblastoma 13.10 10.99 15 365805 308 42255207
Hepatitis B reactivation 13.06 10.99 12 365808 4566 42250949
Neglect of personal appearance 13.05 10.99 16 365804 354 42255161
Platelet transfusion 13.05 10.99 38 365782 1656 42253859
Laboratory test abnormal 13.04 10.99 130 365690 22848 42232667
Confusion postoperative 13.02 10.99 11 365809 153 42255362
Catheter site bruise 13.00 10.99 8 365812 65 42255450
Vaccination site pain 12.97 10.99 7 365813 43 42255472
Ataxia 12.97 10.99 83 365737 16042 42239473
Alcohol poisoning 12.87 10.99 110 365710 7464 42248051
Administration site erythema 12.71 10.99 8 365812 68 42255447
Deafness transitory 12.71 10.99 8 365812 68 42255447
Slow speech 12.70 10.99 39 365781 1751 42253764
Subdural haematoma 12.68 10.99 132 365688 23006 42232509
Bacterial test positive 12.66 10.99 60 365760 3315 42252200
Hypopnoea 12.63 10.99 113 365707 7769 42247746
Hyperlactacidaemia 12.62 10.99 74 365746 4442 42251073
Arrhythmia 12.60 10.99 257 365563 40060 42215455
Hepatitis B 12.59 10.99 24 365796 6687 42248828
Postmortem blood drug level abnormal 12.58 10.99 16 365804 368 42255147
Apathy 12.57 10.99 34 365786 8372 42247143
Insurance issue 12.52 10.99 69 365751 4047 42251468
Febrile nonhaemolytic transfusion reaction 12.52 10.99 10 365810 128 42255387
Dependent personality disorder 12.52 10.99 8 365812 70 42255445
Anion gap increased 12.48 10.99 43 365777 2051 42253464
Pulmonary embolism 12.48 10.99 871 364949 118741 42136774
Polyomavirus-associated nephropathy 12.47 10.99 18 365802 5597 42249918
Victim of homicide 12.46 10.99 12 365808 200 42255315
Exposure via skin contact 12.36 10.99 15 365805 5023 42250492
Osteoporosis 12.36 10.99 76 365744 14830 42240685
Device use error 12.32 10.99 6 365814 3191 42252324
Neoplasm recurrence 12.32 10.99 4 365816 2720 42252795
Major depression 12.31 10.99 84 365736 5314 42250201
Transfusion-related circulatory overload 12.31 10.99 23 365797 746 42254769
Coagulation factor V level decreased 12.31 10.99 13 365807 243 42255272
Fungal infection 12.30 10.99 109 365711 19613 42235902
Rhinitis 12.29 10.99 157 365663 11820 42243695
Dyspnoea at rest 12.29 10.99 11 365809 4238 42251277
Monoparesis 12.28 10.99 5 365815 2955 42252560
Infusion site mass 12.25 10.99 16 365804 378 42255137
Hyper IgE syndrome 12.24 10.99 11 365809 167 42255348
Post embolisation syndrome 12.24 10.99 8 365812 73 42255442
Fibrin D dimer increased 12.23 10.99 79 365741 4906 42250609
Glomerular filtration rate decreased 12.23 10.99 86 365734 16265 42239250
Brain death 12.16 10.99 55 365765 2979 42252536
Cerebral ischaemia 12.11 10.99 26 365794 6933 42248582
Hypocalcaemia 12.09 10.99 184 365636 29989 42225526
Hypotensive crisis 12.06 10.99 8 365812 75 42255440
Miosis 12.04 10.99 172 365648 13274 42242241
White coat hypertension 11.99 10.99 15 365805 339 42255176
Immunoglobulin G4 related disease 11.98 10.99 13 365807 251 42255264
Colitis microscopic 11.89 10.99 6 365814 3127 42252388
Alcoholic coma 11.89 10.99 8 365812 77 42255438
Partial seizures 11.85 10.99 20 365800 5839 42249676
Pneumatosis intestinalis 11.82 10.99 14 365806 4738 42250777
Anti factor V antibody 11.73 10.99 14 365806 301 42255214
Dementia 11.69 10.99 88 365732 16392 42239123
Acute generalised exanthematous pustulosis 11.68 10.99 119 365701 8476 42247039
Hypomagnesaemia 11.67 10.99 173 365647 28315 42227200
Metastases to lymph nodes 11.65 10.99 21 365799 5977 42249538
Respiratory failure 11.63 10.99 944 364876 127188 42128327
Carbon monoxide poisoning 11.61 10.99 9 365811 110 42255405
Injection site erythema 11.57 10.99 114 365706 20081 42235434
Chronic obstructive pulmonary disease 11.51 10.99 434 365386 62680 42192835
Swelling face 11.51 10.99 314 365506 27240 42228275
Blood ethanol increased 11.49 10.99 17 365803 453 42255062
Ultrasound liver abnormal 11.47 10.99 9 365811 112 42255403
Thrombosis 11.44 10.99 476 365344 68035 42187480
Nausea 11.42 10.99 3687 362133 393112 41862403
Muscular weakness 11.36 10.99 593 365227 82905 42172610
Blood loss anaemia 11.34 10.99 44 365776 9692 42245823
Systemic mastocytosis 11.34 10.99 10 365810 148 42255367
Carotid arteriosclerosis 11.32 10.99 3 365817 2329 42253186
Respiratory acidosis 11.32 10.99 93 365727 6238 42249277
Mucosal erosion 11.31 10.99 26 365794 979 42254536
Alpha haemolytic streptococcal infection 11.29 10.99 39 365781 1863 42253652
Injection site pruritus 11.28 10.99 42 365778 9363 42246152
Drug use disorder 11.27 10.99 137 365683 10196 42245319
Oedematous pancreatitis 11.25 10.99 22 365798 739 42254776
Renal fusion anomaly 11.24 10.99 8 365812 85 42255430
Electrocardiogram QRS complex prolonged 11.21 10.99 87 365733 5736 42249779
Prescribed overdose 11.20 10.99 65 365755 12862 42242653
Altered state of consciousness 11.20 10.99 180 365640 29079 42226436
Croup infectious 11.18 10.99 18 365802 517 42254998
Alcohol interaction 11.16 10.99 42 365778 2093 42253422
Postnatal growth restriction 11.15 10.99 11 365809 189 42255326
Status epilepticus 11.14 10.99 83 365737 15495 42240020
Infusion related hypersensitivity reaction 11.08 10.99 12 365808 231 42255284
Upper respiratory tract infection 11.06 10.99 455 365365 41718 42213797
Eosinophil percentage increased 11.02 10.99 19 365801 578 42254937
Prescribed underdose 11.02 10.99 48 365772 10234 42245281
Off label use 11.00 10.99 5827 359993 632508 41623007

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 6796.66 10.52 15718 1194407 464837 108914337
Completed suicide 6779.48 10.52 10611 1199514 231770 109147404
Exposure to toxic agent 2705.16 10.52 1711 1208414 11147 109368027
Intentional overdose 2277.09 10.52 4696 1205429 127805 109251369
Infusion related reaction 1584.60 10.52 8293 1201832 372869 109006305
Acute hepatic failure 1172.26 10.52 1706 1208419 34762 109344412
Overdose 1161.48 10.52 5354 1204771 228440 109150734
Intentional product misuse 1148.48 10.52 3632 1206493 129272 109249902
Drug abuse 1022.05 10.52 4248 1205877 173163 109206011
Blood pressure fluctuation 969.78 10.52 2371 1207754 72453 109306721
Suicide attempt 756.64 10.52 2672 1207453 100722 109278452
Hepatic cytolysis 703.25 10.52 1735 1208390 53318 109325856
Urticaria 635.90 10.52 5794 1204331 313063 109066111
Throat irritation 596.56 10.52 1603 1208522 51949 109327225
Flushing 537.01 10.52 2422 1207703 102314 109276860
Poisoning deliberate 505.55 10.52 978 1209147 25353 109353821
Analgesic drug level increased 502.75 10.52 386 1209739 3560 109375614
Drug ineffective 493.16 10.52 12779 1197346 1507761 107871413
Suspected suicide 484.02 10.52 708 1209417 14491 109364683
Cardio-respiratory arrest 477.14 10.52 2516 1207609 113320 109265854
Metabolic acidosis 476.25 10.52 2259 1207866 97485 109281689
Myelosuppression 461.77 10.52 227 1209898 94113 109285061
Injection site pain 447.63 10.52 787 1209338 177135 109202039
Anaemia 434.01 10.52 3861 1206264 543225 108835949
Blood pressure increased 429.26 10.52 4520 1205605 253853 109125321
Blood pressure systolic increased 428.30 10.52 1923 1208202 81068 109298106
Heart rate decreased 416.95 10.52 1904 1208221 80852 109298322
Respiratory arrest 404.58 10.52 1481 1208644 56818 109322356
Cardiac failure 392.71 10.52 923 1209202 186703 109192471
Product dose omission issue 387.42 10.52 2006 1208119 319776 109059398
Blood pressure diastolic abnormal 384.54 10.52 864 1209261 24951 109354223
Cardiac failure congestive 367.20 10.52 682 1209443 150318 109228856
Diarrhoea 347.86 10.52 9655 1200470 1129850 108249324
Oxygen saturation decreased 338.60 10.52 2903 1207222 154079 109225095
Blood pressure systolic abnormal 331.01 10.52 796 1209329 24054 109355120
Pyroglutamic acidosis 325.98 10.52 230 1209895 1838 109377336
Renal impairment 320.32 10.52 1026 1209099 187419 109191755
Drug resistance 319.05 10.52 109 1210016 56265 109322909
Disease progression 318.67 10.52 1478 1208647 242556 109136618
Malignant neoplasm progression 314.10 10.52 926 1209199 173641 109205533
Anion gap 311.12 10.52 220 1209905 1765 109377409
Myocardial infarction 309.21 10.52 1071 1209054 191012 109188162
Drug interaction 305.03 10.52 3754 1206371 496429 108882745
Heart rate increased 293.64 10.52 2628 1207497 141206 109237968
Poisoning 289.39 10.52 836 1209289 28269 109350905
Medication error 279.05 10.52 2043 1208082 103323 109275851
Pancytopenia 277.53 10.52 1263 1208862 208350 109170824
Intentional product use issue 277.38 10.52 4027 1206098 243879 109135295
Neutropenia 268.10 10.52 2711 1207414 371909 109007265
Cytokine release syndrome 259.19 10.52 1482 1208643 68824 109310350
Acute kidney injury 254.89 10.52 5162 1204963 630268 108748906
Exposure via ingestion 251.47 10.52 289 1209836 4611 109374563
Blood pressure diastolic decreased 240.09 10.52 901 1209224 34984 109344190
Accidental overdose 227.35 10.52 1146 1208979 50688 109328486
Interstitial lung disease 226.16 10.52 774 1209351 138560 109240614
Rheumatoid arthritis 225.67 10.52 4566 1205559 295047 109084127
Ear pruritus 225.13 10.52 334 1209791 6926 109372248
Device expulsion 223.69 10.52 35 1210090 30856 109348318
Pruritus 201.72 10.52 8027 1202098 573533 108805641
Wrong technique in product usage process 198.06 10.52 411 1209714 86937 109292237
Depressed level of consciousness 195.65 10.52 1984 1208141 110294 109268880
Coagulopathy 192.62 10.52 923 1209202 39988 109339186
Hypersensitivity 191.10 10.52 5780 1204345 398218 108980956
Osteonecrosis of jaw 188.71 10.52 149 1209976 47868 109331306
Body temperature increased 179.67 10.52 1119 1209006 53594 109325580
Throat tightness 179.55 10.52 785 1209340 32704 109346470
Hepatotoxicity 178.09 10.52 1247 1208878 62153 109317021
Injection site erythema 174.15 10.52 493 1209632 93683 109285491
Sinusitis 171.57 10.52 4356 1205769 292332 109086842
Atrial fibrillation 171.22 10.52 1645 1208480 227997 109151177
Renal failure 166.40 10.52 1629 1208496 224945 109154229
Respiratory depression 164.67 10.52 741 1209384 31260 109347914
Hyperkalaemia 163.01 10.52 847 1209278 134949 109244225
Anaphylactic reaction 161.19 10.52 1937 1208188 112363 109266811
Folliculitis 160.50 10.52 2653 1207472 165000 109214174
Nasopharyngitis 159.47 10.52 5538 1204587 388823 108990351
Irritable bowel syndrome 154.77 10.52 2592 1207533 161623 109217551
Duodenal ulcer perforation 154.22 10.52 2768 1207357 174932 109204242
Sopor 151.87 10.52 107 1210018 36439 109342735
Therapy interrupted 149.75 10.52 195 1209930 49627 109329547
Muscle injury 148.67 10.52 2265 1207860 138542 109240632
Pneumonia 148.25 10.52 7963 1202162 868751 108510423
Urine abnormality 147.46 10.52 315 1209810 8781 109370393
Bone marrow failure 147.12 10.52 254 1209871 57594 109321580
Pharyngeal paraesthesia 145.59 10.52 202 1209923 3930 109375244
Therapy cessation 143.84 10.52 167 1209958 44690 109334484
Thrombocytopenia 142.99 10.52 2823 1207302 346062 109033112
Neuropathy peripheral 141.47 10.52 1266 1208859 178011 109201163
Septic shock 139.92 10.52 1078 1209047 156450 109222724
Injection site bruising 137.90 10.52 217 1209908 51046 109328128
Lower respiratory tract infection 136.61 10.52 3556 1206569 239550 109139624
Blood pressure diastolic increased 136.60 10.52 485 1209640 18322 109360852
Neoplasm progression 136.50 10.52 316 1209809 64279 109314895
Tachycardia 136.44 10.52 3346 1206779 223299 109155875
Therapeutic product effect incomplete 136.07 10.52 1680 1208445 222125 109157049
Helicobacter infection 135.92 10.52 2769 1207356 179108 109200066
Hospitalisation 134.74 10.52 958 1209167 141535 109237639
Gastrointestinal haemorrhage 133.62 10.52 1162 1208963 164356 109214818
Ill-defined disorder 132.49 10.52 2433 1207692 154420 109224754
Cytomegalovirus infection 132.22 10.52 246 1209879 54198 109324976
Respiratory failure 131.82 10.52 1614 1208511 213718 109165456
Poor venous access 131.60 10.52 575 1209550 23947 109355227
Prothrombin time ratio decreased 130.94 10.52 121 1210004 1471 109377703
Chills 128.69 10.52 2859 1207266 187721 109191453
Hepatic enzyme increased 127.10 10.52 4496 1205629 316396 109062778
Leukopenia 124.40 10.52 1035 1209090 147756 109231418
Full blood count abnormal 124.34 10.52 267 1209858 55785 109323389
Infusion site pruritus 124.25 10.52 208 1209917 4800 109374374
Cerebral infarction 123.45 10.52 237 1209888 51601 109327573
Impaired healing 121.96 10.52 2916 1207209 193801 109185373
Dehydration 120.84 10.52 2241 1207884 277270 109101904
Sleep disorder due to general medical condition, insomnia type 120.39 10.52 1722 1208403 103921 109275253
Infusion site erythema 120.33 10.52 345 1209780 11614 109367560
Post transplant lymphoproliferative disorder 119.37 10.52 15 1210110 15598 109363576
Liver injury 117.39 10.52 2305 1207820 148108 109231066
Urine leukocyte esterase positive 117.14 10.52 174 1209951 3612 109375562
Hand deformity 116.39 10.52 3174 1206951 215332 109163842
Cerebrovascular accident 115.86 10.52 1346 1208779 179938 109199236
Cerebral haemorrhage 115.81 10.52 346 1209779 64622 109314552
Dyspnoea exertional 115.57 10.52 666 1209459 103394 109275780
Hepatic necrosis 115.54 10.52 302 1209823 9620 109369554
Anticholinergic syndrome 113.25 10.52 183 1209942 4097 109375077
Pathogen resistance 113.23 10.52 27 1210098 17645 109361529
Heart rate irregular 112.54 10.52 701 1209424 33573 109345601
Inappropriate schedule of product administration 111.59 10.52 2969 1207156 200668 109178506
Syncope 111.50 10.52 1552 1208573 200984 109178190
Synovitis 110.19 10.52 3847 1206278 270245 109108929
Posterior reversible encephalopathy syndrome 109.72 10.52 125 1210000 33736 109345438
Weight increased 109.61 10.52 5629 1204496 414015 108965159
Coronary artery disease 109.15 10.52 409 1209716 71281 109307893
Haematotoxicity 108.93 10.52 47 1210078 21035 109358139
Coma 108.68 10.52 1854 1208271 116015 109263159
Anti-cyclic citrullinated peptide antibody positive 107.81 10.52 2681 1207444 179303 109199871
Myelodysplastic syndrome 106.32 10.52 153 1209972 37331 109341843
Fall 105.84 10.52 5460 1204665 598022 108781152
Thrombotic microangiopathy 104.16 10.52 99 1210026 29050 109350124
Sepsis 103.82 10.52 2756 1207369 324590 109054584
Acute myeloid leukaemia 101.87 10.52 162 1209963 37948 109341226
Infusion site pain 101.66 10.52 419 1209706 17000 109362174
Drug dose omission by device 101.65 10.52 18 1210107 14498 109364676
Blister 100.73 10.52 3228 1206897 224148 109155026
Prostate cancer 100.62 10.52 160 1209965 37481 109341693
Multiple-drug resistance 100.49 10.52 13 1210112 13222 109365952
Mydriasis 99.36 10.52 493 1209632 21664 109357510
Erythema 98.55 10.52 4013 1206112 287434 109091740
Pulmonary hypertension 98.49 10.52 294 1209831 54926 109324248
Discomfort 98.48 10.52 3061 1207064 211646 109167528
Body temperature decreased 98.23 10.52 717 1209408 36218 109342956
Hepatic function abnormal 97.83 10.52 574 1209551 88721 109290453
White blood cells urine positive 96.98 10.52 238 1209887 7286 109371888
Diabetic ketoacidosis 96.95 10.52 196 1209929 41862 109337312
Hypothyroidism 96.57 10.52 439 1209686 72460 109306714
Infusion site swelling 96.54 10.52 282 1209843 9595 109369579
Unresponsive to stimuli 95.67 10.52 1094 1209031 62696 109316478
Acute myocardial infarction 95.29 10.52 532 1209593 83245 109295929
Pemphigus 94.99 10.52 3046 1207079 211524 109167650
Pulmonary alveolar haemorrhage 94.84 10.52 51 1210074 20099 109359075
Respiratory rate increased 94.58 10.52 532 1209593 24551 109354623
Product substitution issue 93.89 10.52 69 1210056 22992 109356182
Transplant rejection 93.10 10.52 79 1210046 24488 109354686
Platelet count decreased 92.74 10.52 1870 1208255 228573 109150601
Glossodynia 91.23 10.52 3124 1207001 218880 109160294
Crystal urine present 90.66 10.52 110 1210015 1864 109377310
Visual acuity reduced 90.58 10.52 132 1209993 32041 109347133
Hyponatraemia 90.36 10.52 1757 1208368 215896 109163278
Food allergy 90.27 10.52 445 1209680 19503 109359671
Pericarditis 89.70 10.52 3082 1207043 216032 109163142
Pulmonary arterial hypertension 89.38 10.52 136 1209989 32432 109346742
Aspergillus infection 89.22 10.52 89 1210036 25527 109353647
Infusion site extravasation 88.80 10.52 305 1209820 11329 109367845
Feeling hot 88.75 10.52 1446 1208679 89660 109289514
Decreased appetite 87.66 10.52 4283 1205842 471563 108907611
Immune reconstitution inflammatory syndrome 87.36 10.52 34 1210091 16192 109362982
Graft versus host disease 86.48 10.52 49 1210076 18757 109360417
Oedema peripheral 86.26 10.52 2839 1207286 325821 109053353
Polyneuropathy 84.70 10.52 137 1209988 31875 109347299
Cytopenia 84.36 10.52 124 1210001 29992 109349182
Pneumocystis jirovecii pneumonia 84.05 10.52 217 1209908 42518 109336656
Chronic kidney disease 83.79 10.52 490 1209635 75801 109303373
Diabetes mellitus 83.65 10.52 690 1209435 98691 109280483
Device difficult to use 83.64 10.52 51 1210074 18754 109360420
Bladder cancer 83.54 10.52 60 1210065 20232 109358942
Postmortem blood drug level increased 82.19 10.52 83 1210042 1134 109378040
Wound 81.78 10.52 3239 1206886 231198 109147976
Labelled drug-drug interaction medication error 81.74 10.52 121 1210004 29181 109349993
Cardiac arrest 81.67 10.52 2772 1207353 193981 109185193
Injection site swelling 81.31 10.52 373 1209752 61417 109317757
Cardiac failure chronic 81.15 10.52 25 1210100 13786 109365388
Chest discomfort 80.64 10.52 2482 1207643 171366 109207808
Haemorrhage 80.44 10.52 762 1209363 105930 109273244
Injury 79.64 10.52 2521 1207604 174744 109204430
Oesophageal carcinoma 79.17 10.52 15 1210110 11509 109367665
Second primary malignancy 78.98 10.52 50 1210075 18018 109361156
Product storage error 78.57 10.52 73 1210052 21655 109357519
Hepatitis fulminant 78.55 10.52 239 1209886 8321 109370853
Palmar-plantar erythrodysaesthesia syndrome 77.89 10.52 212 1209913 40813 109338361
Arthropathy 77.32 10.52 3868 1206257 283654 109095520
Forced expiratory volume decreased 77.15 10.52 24 1210101 13152 109366022
Disease recurrence 77 10.52 372 1209753 60412 109318762
Bronchopulmonary aspergillosis 76.97 10.52 130 1209995 29733 109349441
Transient ischaemic attack 76.81 10.52 399 1209726 63583 109315591
Product use in unapproved indication 76.02 10.52 4060 1206065 443317 108935857
Sedation complication 75.44 10.52 422 1209703 19433 109359741
Somnolence 74.79 10.52 3976 1206149 293473 109085701
Osteonecrosis 74.61 10.52 161 1209964 33580 109345594
Hypocalcaemia 74.39 10.52 415 1209710 64951 109314223
Cytomegalovirus viraemia 73.83 10.52 52 1210073 17712 109361462
Hepatitis acute 73.41 10.52 402 1209723 18364 109360810
Eosinophilic granulomatosis with polyangiitis 73.22 10.52 14 1210111 10672 109368502
BK virus infection 73.02 10.52 26 1210099 13080 109366094
Injection site haemorrhage 72.70 10.52 158 1209967 32870 109346304
Therapy partial responder 72.26 10.52 189 1209936 36872 109342302
Drug ineffective for unapproved indication 71.88 10.52 748 1209377 102090 109277084
Lymphocyte percentage decreased 71.69 10.52 171 1209954 5139 109374035
Metastases to liver 71.67 10.52 177 1209948 35209 109343965
Cardiac failure acute 71.58 10.52 95 1210030 23983 109355191
Urinary sediment present 70.89 10.52 111 1210014 2417 109376757
Systemic lupus erythematosus 70.55 10.52 3432 1206693 250906 109128268
Neutrophil percentage increased 70.46 10.52 162 1209963 4751 109374423
Lymphocyte count decreased 70.44 10.52 946 1209179 56297 109322877
Fixed eruption 70.27 10.52 148 1209977 4084 109375090
White blood cell count decreased 70.17 10.52 1941 1208184 227449 109151725
Temperature regulation disorder 69.78 10.52 302 1209823 12524 109366650
Systemic infection 69.14 10.52 12 1210113 9807 109369367
Acute lung injury 67.92 10.52 123 1210002 3028 109376146
Surgery 67.18 10.52 229 1209896 41054 109338120
Haematuria 66.40 10.52 584 1209541 82421 109296753
Device malfunction 66.11 10.52 111 1210014 25447 109353727
Melaena 66.09 10.52 460 1209665 68297 109310877
Right ventricular failure 65.05 10.52 115 1210010 25839 109353335
Sleep disorder due to a general medical condition 64.81 10.52 321 1209804 51791 109327383
Acute graft versus host disease 64.54 10.52 30 1210095 12851 109366323
Cross sensitivity reaction 64.37 10.52 169 1209956 5398 109373776
Hepatic failure 64.36 10.52 1084 1209041 67655 109311519
Swelling 64.30 10.52 4564 1205561 346477 109032697
Rheumatic fever 64.22 10.52 1777 1208348 120802 109258372
Neurotoxicity 64.11 10.52 241 1209884 41966 109337208
Acute graft versus host disease in skin 63.91 10.52 19 1210106 10721 109368453
Anion gap abnormal 63.89 10.52 61 1210064 775 109378399
Mobility decreased 63.81 10.52 3194 1206931 234228 109144946
Myalgia 62.90 10.52 1902 1208223 220479 109158695
Product monitoring error 62.67 10.52 11 1210114 8916 109370258
Gastrointestinal disorder 62.38 10.52 3242 1206883 238710 109140464
Obstructive airways disorder 62.27 10.52 276 1209849 45873 109333301
Endophthalmitis 62.26 10.52 8 1210117 8179 109370995
Psoriasis 62.15 10.52 1117 1209008 138876 109240298
Accidental death 61.99 10.52 156 1209969 4853 109374321
Body temperature fluctuation 61.55 10.52 131 1209994 3642 109375532
Chronic graft versus host disease 61.48 10.52 14 1210111 9443 109369731
Product prescribing error 61.11 10.52 321 1209804 51010 109328164
Myopathy 60.41 10.52 113 1210012 24847 109354327
Renal disorder 59.70 10.52 308 1209817 49171 109330003
Epistaxis 58.90 10.52 1037 1209088 129335 109249839
Blood glucose increased 58.87 10.52 1057 1209068 131439 109247735
Injection site pruritus 58.56 10.52 325 1209800 50933 109328241
Pyroglutamate increased 58.56 10.52 52 1210073 598 109378576
Oral pruritus 58.53 10.52 119 1210006 3201 109375973
Hereditary angioedema 58.28 10.52 191 1209934 6923 109372251
Unevaluable event 58.03 10.52 394 1209731 58833 109320341
Bursitis 57.91 10.52 1846 1208279 128072 109251102
Nocardiosis 57.70 10.52 7 1210118 7479 109371695
Hypotension 57.64 10.52 6562 1203563 517287 108861887
Epstein-Barr virus infection 56.66 10.52 73 1210052 18665 109360509
Multiple organ dysfunction syndrome 56.64 10.52 1246 1208879 150464 109228710
Unintentional medical device removal 56.45 10.52 14 1210111 8909 109370265
Angioedema 56.21 10.52 1444 1208681 97056 109282118
Subdural haematoma 56.12 10.52 207 1209918 36247 109342927
Vomiting 55.45 10.52 11030 1199095 899645 108479529
Pleural effusion 55.03 10.52 1501 1208624 176208 109202966
Asthenia 54.98 10.52 6650 1203475 682349 108696825
Treatment noncompliance 54.71 10.52 522 1209603 72468 109306706
Acute respiratory failure 53.58 10.52 545 1209580 74715 109304459
Hypomagnesaemia 53.17 10.52 414 1209711 59956 109319218
Generalised bullous fixed drug eruption 52.78 10.52 54 1210071 750 109378424
Abortion spontaneous 52.56 10.52 195 1209930 34087 109345087
Injection site mass 52.33 10.52 120 1210005 24493 109354681
Full blood count decreased 52.27 10.52 178 1209947 31921 109347253
Drug hypersensitivity 51.83 10.52 5702 1204423 448388 108930786
Creatinine renal clearance decreased 51.58 10.52 412 1209713 21403 109357771
Ischaemic stroke 51.41 10.52 254 1209871 41009 109338165
Cytomegalovirus infection reactivation 50.85 10.52 76 1210049 18257 109360917
Incorrect drug administration rate 50.74 10.52 154 1209971 5354 109373820
Plasma cell myeloma 50.69 10.52 442 1209683 62494 109316680
Inspiratory capacity decreased 50.56 10.52 97 1210028 2498 109376676
Immunosuppressant drug level increased 50.49 10.52 33 1210092 11691 109367483
Ascites 50.40 10.52 713 1209412 92095 109287079
Mucosal inflammation 50.32 10.52 744 1209381 95397 109283777
Exposure via skin contact 50.16 10.52 42 1210083 13105 109366069
Device leakage 50.11 10.52 61 1210064 15987 109363187
Hypertensive crisis 50.07 10.52 121 1210004 24251 109354923
Infusion site rash 49.92 10.52 91 1210034 2252 109376922
Graft versus host disease in gastrointestinal tract 49.61 10.52 18 1210107 8950 109370224
Device issue 49.39 10.52 202 1209923 34333 109344841
Dry skin 49.36 10.52 854 1209271 106799 109272375
Gastric cancer 48.76 10.52 30 1210095 10978 109368196
Hypokalaemia 48.54 10.52 1573 1208552 180875 109198299
Weight fluctuation 48.48 10.52 411 1209714 21734 109357440
Neuritis 48.01 10.52 11 1210114 7388 109371786
Environmental exposure 47.69 10.52 37 1210088 347 109378827
Thrombosis 47.60 10.52 869 1209256 107793 109271381
Dyspnoea 47.53 10.52 11060 1199065 1095812 108283362
Device use error 47.38 10.52 20 1210105 9069 109370105
Red blood cells urine positive 46.86 10.52 144 1209981 5041 109374133
Hepatitis B reactivation 46.85 10.52 12 1210113 7472 109371702
Specific gravity urine decreased 46.73 10.52 53 1210072 833 109378341
Incorrect dose administered by device 46.53 10.52 9 1210116 6805 109372369
Condition aggravated 46.33 10.52 7196 1202929 727640 108651534
Breast cancer stage I 45.95 10.52 12 1210113 7375 109371799
Mitral valve incompetence 45.77 10.52 198 1209927 33131 109346043
Glycosylated haemoglobin increased 45.63 10.52 121 1210004 23498 109355676
Device dislocation 45.62 10.52 185 1209940 31519 109347655
Coeliac disease 45.28 10.52 694 1209431 42493 109336681
Graft versus host disease in skin 44.93 10.52 17 1210108 8237 109370937
Dissociation 44.75 10.52 26 1210099 9816 109369358
Rash 44.72 10.52 9891 1200234 811073 108568101
Injection site warmth 44.64 10.52 76 1210049 17329 109361845
Lactic acidosis 44.59 10.52 730 1209395 92081 109287093
Breast cancer 44.23 10.52 244 1209881 38298 109340876
Haematochezia 44.22 10.52 945 1209180 114579 109264595
Circulatory collapse 44.14 10.52 282 1209843 42711 109336463
Pulmonary vasculitis 44.10 10.52 9 1210116 6551 109372623
Rhabdomyolysis 44.04 10.52 992 1209133 119409 109259765
Joint swelling 44.01 10.52 5512 1204613 437333 108941841
Pharyngeal swelling 43.92 10.52 253 1209872 11779 109367395
Cardiac disorder 43.58 10.52 580 1209545 75700 109303474
Alanine aminotransferase increased 43.49 10.52 2443 1207682 181330 109197844
Staphylococcal infection 43.25 10.52 523 1209602 69421 109309753
Venoocclusive liver disease 43.20 10.52 62 1210063 15145 109364029
Urinary tract infection 43.08 10.52 3031 1207094 323251 109055923
Colorectal cancer 42.99 10.52 23 1210102 9091 109370083
Medication overuse headache 42.96 10.52 68 1210057 1495 109377679
Hypocoagulable state 42.90 10.52 91 1210034 2524 109376650
Breast cancer female 42.64 10.52 44 1210081 12424 109366750
Contraindicated product administered 42.57 10.52 3211 1206914 245056 109134118
Gait disturbance 42.42 10.52 2551 1207574 275657 109103517
Clostridium test positive 42.37 10.52 233 1209892 10660 109368514
Transplant dysfunction 42.34 10.52 19 1210106 8309 109370865
Coronary arterial stent insertion 42.16 10.52 7 1210118 5908 109373266
Candida infection 41.92 10.52 330 1209795 47679 109331495
Pulmonary embolism 41.90 10.52 1918 1208207 212556 109166618
Mucormycosis 41.73 10.52 33 1210092 10595 109368579
Metastases to lung 41.70 10.52 122 1210003 22941 109356233
Urine ketone body present 41.69 10.52 114 1210011 3732 109375442
Fibromyalgia 41.42 10.52 2277 1207848 168632 109210542
Cardiomyopathy 41.41 10.52 207 1209918 33318 109345856
Joint range of motion decreased 41.24 10.52 1678 1208447 120154 109259020
Sexual dysfunction 41.02 10.52 21 1210104 8509 109370665
Hepatocellular carcinoma 40.95 10.52 29 1210096 9851 109369323
Metastases to bone 40.90 10.52 190 1209935 31182 109347992
Brain death 40.66 10.52 161 1209964 6412 109372762
Erectile dysfunction 40.65 10.52 89 1210036 18467 109360707
Renal papillary necrosis 40.61 10.52 36 1210089 413 109378761
Tongue disorder 40.60 10.52 282 1209843 14016 109365158
Left ventricular dysfunction 40.52 10.52 127 1209998 23366 109355808
Headache 40.28 10.52 10547 1199578 871830 108507344
Electric shock 40.22 10.52 72 1210053 1756 109377418
Angina unstable 40.11 10.52 74 1210051 16358 109362816
Lung neoplasm malignant 40.08 10.52 212 1209913 33630 109345544
Lip dry 39.99 10.52 1404 1208721 98679 109280495
Skin toxicity 39.83 10.52 42 1210083 11741 109367433
Oropharyngeal pain 39.74 10.52 1836 1208289 133440 109245734
Swollen joint count increased 39.73 10.52 1198 1208927 82463 109296711
Syringe issue 39.43 10.52 28 1210097 9497 109369677
Blood calcium decreased 39.13 10.52 580 1209545 35265 109343909
Cholecystitis chronic 38.85 10.52 206 1209919 9294 109369880
Blood pH decreased 38.83 10.52 126 1209999 4543 109374631
Pericardial effusion 38.83 10.52 419 1209706 56798 109322376
Brain oedema 38.70 10.52 515 1209610 30583 109348591
Deep vein thrombosis 38.66 10.52 1200 1208925 138687 109240487
Chronic obstructive pulmonary disease 38.62 10.52 904 1209221 108254 109270920
Rebound effect 38.58 10.52 64 1210061 14742 109364432
Prothrombin time shortened 38.46 10.52 107 1210018 3539 109375635
Squamous cell carcinoma 38.46 10.52 91 1210034 18372 109360802
Hypertriglyceridaemia 38.33 10.52 74 1210051 16080 109363094
JC virus infection 38.29 10.52 6 1210119 5284 109373890
Conjunctivitis allergic 38.19 10.52 14 1210111 6917 109372257
Hypomania 38.13 10.52 216 1209909 9994 109369180
Pneumatosis intestinalis 38.12 10.52 23 1210102 8506 109370668
Haemoptysis 38.10 10.52 550 1209575 70804 109308370
Pancreatic carcinoma 38.09 10.52 65 1210060 14807 109364367
C-reactive protein abnormal 38.04 10.52 1760 1208365 127935 109251239
Facet joint syndrome 37.86 10.52 1355 1208770 95473 109283701
Infusion site urticaria 37.79 10.52 56 1210069 1160 109378014
Migraine 37.76 10.52 2267 1207858 169385 109209789
Renal cortical necrosis 37.72 10.52 37 1210088 487 109378687
Respiratory symptom 37.65 10.52 66 1210059 14879 109364295
Infusion site bruising 37.58 10.52 107 1210018 3587 109375587
Congestive cardiomyopathy 37.48 10.52 61 1210064 14158 109365016
Lymphoproliferative disorder 37.44 10.52 16 1210109 7202 109371972
Aplastic anaemia 37.40 10.52 419 1209706 23889 109355285
Hypervolaemia 37.38 10.52 353 1209772 49107 109330067
Electrocardiogram QRS complex prolonged 37.08 10.52 257 1209868 12764 109366410
Hepatitis C 36.97 10.52 50 1210075 12523 109366651
Polyomavirus-associated nephropathy 36.81 10.52 22 1210103 8179 109370995
Drug use disorder 36.73 10.52 330 1209795 17744 109361430
Varicella zoster virus infection 36.58 10.52 12 1210113 6356 109372818
Spinal stenosis 36.53 10.52 98 1210027 18958 109360216
Pain 36.49 10.52 11331 1198794 943624 108435550
Mycotic allergy 36.41 10.52 10 1210115 5944 109373230
Hepatic cancer 36.34 10.52 41 1210084 11115 109368059
Needle issue 36.31 10.52 89 1210036 17751 109361423
Agranulocytosis 36.23 10.52 467 1209658 61293 109317881
Hyperglycaemia 36.17 10.52 684 1209441 84406 109294768
Large intestine polyp 36.09 10.52 69 1210056 15048 109364126
Cytomegalovirus colitis 36.07 10.52 16 1210109 7045 109372129
Disturbance in social behaviour 36.02 10.52 6 1210119 5052 109374122
Kidney transplant rejection 35.93 10.52 47 1210078 11940 109367234
Anion gap increased 35.92 10.52 117 1210008 4227 109374947
Tuberculosis 35.92 10.52 89 1210036 17685 109361489
Specific gravity urine increased 35.53 10.52 36 1210089 494 109378680
Cystitis haemorrhagic 35.45 10.52 49 1210076 12160 109367014
Renal cancer 35.22 10.52 55 1210070 12979 109366195
Human herpesvirus 6 infection 35.09 10.52 14 1210111 6567 109372607
Analgesic drug level above therapeutic 34.90 10.52 35 1210090 474 109378700
Infective pulmonary exacerbation of cystic fibrosis 34.76 10.52 68 1210057 14703 109364471
Prostatic specific antigen increased 34.57 10.52 52 1210073 12459 109366715
Bacterial test 34.45 10.52 53 1210072 1136 109378038
Oropharyngeal discomfort 34.39 10.52 212 1209913 10115 109369059
Blood creatine phosphokinase increased 34.38 10.52 577 1209548 72500 109306674
Diffuse large B-cell lymphoma recurrent 34.24 10.52 13 1210112 6286 109372888
Drug screen positive 34.16 10.52 150 1209975 6260 109372914
Night sweats 34.05 10.52 1793 1208332 132190 109246984
Premature delivery 34.03 10.52 196 1209929 30436 109348738
Status epilepticus 34.01 10.52 204 1209921 31367 109347807
Febrile neutropenia 33.98 10.52 3962 1206163 312805 109066369
Klebsiella infection 33.93 10.52 109 1210016 19900 109359274
Substance abuse 33.75 10.52 243 1209882 12220 109366954
Therapeutic response shortened 33.60 10.52 482 1209643 29101 109350073
Blood loss anaemia 33.58 10.52 94 1210031 17931 109361243
Metastases to central nervous system 33.55 10.52 132 1209993 22685 109356489
Injection site rash 33.48 10.52 137 1209988 23282 109355892
Bacterial test positive 33.32 10.52 174 1209951 7803 109371371
Leukoencephalopathy 33.12 10.52 31 1210094 9164 109370010
Red cell distribution width increased 33.06 10.52 316 1209809 17286 109361888
Cardiotoxicity 32.98 10.52 86 1210039 16795 109362379
Ear pain 32.96 10.52 789 1209336 52437 109326737
Infusion site mass 32.94 10.52 64 1210061 1664 109377510
Blood urine present 32.91 10.52 408 1209717 23837 109355337
Urine analysis abnormal 32.75 10.52 156 1209969 6741 109372433
Visual impairment 32.72 10.52 1172 1208953 133256 109245918
Product dose omission in error 32.71 10.52 139 1209986 23373 109355801
Actinic keratosis 32.64 10.52 18 1210107 6995 109372179
Anuria 32.58 10.52 146 1209979 24195 109354979
Enterococcal infection 32.44 10.52 114 1210011 20252 109358922
Accidental poisoning 32.41 10.52 79 1210046 2408 109376766
Immunodeficiency 32.27 10.52 601 1209524 38237 109340937
Macular oedema 32.25 10.52 18 1210107 6948 109372226
Drug-induced liver injury 32.18 10.52 1615 1208510 118452 109260722
Electrolyte imbalance 32.11 10.52 255 1209870 36773 109342401
Sinus tachycardia 32.09 10.52 674 1209451 43819 109335355
Muscle spasticity 32.04 10.52 562 1209563 35353 109343821
Cerebral ischaemia 31.83 10.52 52 1210073 12052 109367122
Vision blurred 31.83 10.52 1123 1209002 127899 109251275
Proteinuria 31.81 10.52 282 1209843 39736 109339438
Aggression 31.75 10.52 456 1209669 58754 109320420
Sedation 31.54 10.52 992 1209133 68691 109310483
Pain in jaw 31.13 10.52 384 1209741 50793 109328381
Contusion 30.97 10.52 2961 1207164 230400 109148774
Ovarian hyperstimulation syndrome 30.96 10.52 10 1210115 5350 109373824
Monocyte percentage increased 30.91 10.52 74 1210051 2229 109376945
Neurological symptom 30.89 10.52 79 1210046 15529 109363645
Loss of personal independence in daily activities 30.85 10.52 1334 1208791 148686 109230488
Cytomegalovirus chorioretinitis 30.78 10.52 20 1210105 7108 109372066
Tachyarrhythmia 30.77 10.52 27 1210098 8234 109370940
Suicidal ideation 30.76 10.52 787 1209338 93150 109286024
Deafness transitory 30.66 10.52 48 1210077 1045 109378129
Complications of transplanted kidney 30.64 10.52 22 1210103 7420 109371754
Spinal compression fracture 30.62 10.52 101 1210024 18291 109360883
Serum sickness 30.62 10.52 112 1210013 4294 109374880
Hyperthyroidism 30.52 10.52 191 1209934 29070 109350104
Complication of device insertion 30.44 10.52 31 1210094 8807 109370367
Pulmonary tuberculosis 30.42 10.52 33 1210092 9106 109370068
Iron deficiency anaemia 30.39 10.52 211 1209914 31348 109347826
General physical health deterioration 30.29 10.52 4134 1205991 421161 108958013
Rash erythematous 30.26 10.52 1138 1208987 80694 109298480
Nitrite urine present 30.25 10.52 51 1210074 1184 109377990
Acute graft versus host disease in intestine 30.06 10.52 12 1210113 5627 109373547
Hepatic encephalopathy 29.98 10.52 455 1209670 27801 109351373
Leukaemia 29.96 10.52 23 1210102 7495 109371679
Nephropathy toxic 29.89 10.52 177 1209948 27301 109351873
Injection site induration 29.85 10.52 49 1210076 11334 109367840
Intestinal haemorrhage 29.84 10.52 22 1210103 7319 109371855
Product use issue 29.84 10.52 3871 1206254 307824 109071350
Febrile bone marrow aplasia 29.71 10.52 95 1210030 17370 109361804
Neuroblastoma recurrent 29.67 10.52 33 1210092 507 109378667
Hyperlipidaemia 29.66 10.52 250 1209875 35598 109343576
Heart rate abnormal 29.63 10.52 157 1209968 7081 109372093
Toxic skin eruption 29.53 10.52 178 1209947 27337 109351837
Acute coronary syndrome 29.53 10.52 141 1209984 22971 109356203
Toxicologic test abnormal 29.43 10.52 52 1210073 1255 109377919
Disturbance in attention 29.32 10.52 489 1209636 61506 109317668
Aplasia pure red cell 29.29 10.52 37 1210088 9541 109369633
Culture urine positive 29.29 10.52 117 1210008 4679 109374495
Hypoglycaemic coma 29.12 10.52 12 1210113 5521 109373653
Ejection fraction decreased 29.11 10.52 296 1209829 40584 109338590
Eosinophilia 29.06 10.52 452 1209673 57484 109321690
Accidental exposure to product 29.02 10.52 379 1209746 49629 109329545
Pemphigoid 28.98 10.52 114 1210011 19593 109359581
Wrong technique in device usage process 28.94 10.52 20 1210105 6881 109372293
Ischaemic cardiomyopathy 28.87 10.52 27 1210098 7984 109371190
Infection reactivation 28.71 10.52 5 1210120 4076 109375098
Cellulitis 28.58 10.52 1108 1209017 124908 109254266
Adenocarcinoma of colon 28.46 10.52 16 1210109 6152 109373022
Hyperhidrosis 28.44 10.52 2400 1207725 184898 109194276
Anticipatory anxiety 28.32 10.52 50 1210075 1206 109377968
Squamous cell carcinoma of skin 28.28 10.52 95 1210030 17108 109362066
Personality change 28.25 10.52 48 1210077 10954 109368220
Paraesthesia ear 28.21 10.52 32 1210093 503 109378671
Adenovirus infection 28.20 10.52 48 1210077 10946 109368228
Accidental exposure to product by child 28.15 10.52 88 1210037 3110 109376064
Arrhythmia 28.14 10.52 564 1209561 69011 109310163
Carotid artery stenosis 28.10 10.52 36 1210089 9227 109369947
Progressive multifocal leukoencephalopathy 28.09 10.52 159 1209966 24797 109354377
Bundle branch block left 28.08 10.52 62 1210063 12826 109366348
Ageusia 28.03 10.52 115 1210010 19530 109359644
Drug specific antibody present 28.00 10.52 173 1209952 8261 109370913
Infusion site discomfort 27.94 10.52 62 1210063 1775 109377399
Paradoxical drug reaction 27.91 10.52 40 1210085 9777 109369397
Retinal haemorrhage 27.72 10.52 38 1210087 9463 109369711
Abdominal pain 27.72 10.52 6179 1203946 506810 108872364
Sudden infant death syndrome 27.69 10.52 26 1210099 323 109378851
Ataxia 27.68 10.52 204 1209921 29904 109349270
Epstein-Barr virus associated lymphoproliferative disorder 27.67 10.52 9 1210116 4793 109374381
Blood cholesterol increased 27.62 10.52 2365 1207760 182420 109196754
Vein rupture 27.59 10.52 76 1210049 2499 109376675
Acidosis 27.57 10.52 372 1209753 22159 109357015
Metastases to lymph nodes 27.55 10.52 79 1210046 14953 109364221
Embolic stroke 27.55 10.52 33 1210092 8710 109370464
Normochromic normocytic anaemia 27.48 10.52 64 1210061 12993 109366181
Intraocular pressure increased 27.43 10.52 48 1210077 10828 109368346
Abnormal dreams 27.42 10.52 62 1210063 12718 109366456
Cryopyrin associated periodic syndrome 27.37 10.52 34 1210091 591 109378583
Drug level below therapeutic 27.35 10.52 220 1209905 11453 109367721
Dysstasia 27.31 10.52 230 1209895 32756 109346418
Acute myeloid leukaemia recurrent 27.29 10.52 11 1210114 5128 109374046
Arteriosclerosis 27.23 10.52 159 1209966 24608 109354566
Peripheral arterial occlusive disease 27.19 10.52 37 1210088 9243 109369931
Agitation 27.15 10.52 1505 1208620 111546 109267628
Haematoma 27.09 10.52 463 1209662 58013 109321161
Haemophagocytic lymphohistiocytosis 27.06 10.52 218 1209907 31341 109347833
Tricuspid valve incompetence 26.92 10.52 152 1209973 23721 109355453
Transplant failure 26.91 10.52 14 1210111 5621 109373553
Hypertension 26.89 10.52 6137 1203988 503947 108875227
Angina pectoris 26.71 10.52 500 1209625 61795 109317379
Dyskinesia 26.61 10.52 399 1209726 51047 109328127
Bezoar 26.46 10.52 101 1210024 3953 109375221
Mixed liver injury 26.34 10.52 224 1209901 11855 109367319
Haemoglobin urine present 26.24 10.52 41 1210084 891 109378283
Feeling cold 26.21 10.52 520 1209605 33467 109345707
Methaemoglobinaemia 26.14 10.52 181 1209944 8987 109370187
Peritonitis bacterial 26.10 10.52 47 1210078 10486 109368688
Neutrophil count decreased 26.00 10.52 1070 1209055 119871 109259303
Aspartate aminotransferase increased 25.99 10.52 2060 1208065 157876 109221298
Ketoacidosis 25.91 10.52 44 1210081 10043 109369131
Tardive dyskinesia 25.90 10.52 70 1210055 13509 109365665
Diverticulum intestinal 25.84 10.52 56 1210069 11663 109367511
Loss of consciousness 25.82 10.52 1824 1208301 194482 109184692
Inflammation 25.80 10.52 2453 1207672 190785 109188389
Disseminated tuberculosis 25.76 10.52 12 1210113 5134 109374040
Catheter site bruise 25.64 10.52 32 1210093 559 109378615
Seizure 25.49 10.52 2078 1208047 219107 109160067
Impaired quality of life 25.44 10.52 208 1209917 29809 109349365
Inappropriate antidiuretic hormone secretion 25.41 10.52 242 1209883 33609 109345565
Gestational diabetes 25.36 10.52 26 1210099 7363 109371811
BRASH syndrome 25.25 10.52 5 1210120 3718 109375456
Diplopia 25.24 10.52 315 1209810 41579 109337595
Asthma 25.22 10.52 2376 1207749 247915 109131259
Dizziness 25.18 10.52 7030 1203095 691163 108688011
Nocturia 25.17 10.52 98 1210027 16892 109362282
Lipodystrophy acquired 25.16 10.52 9 1210116 4515 109374659
Pharyngitis 25.05 10.52 400 1209725 24698 109354476
Haemoglobin decreased 24.95 10.52 2362 1207763 246365 109132809
Schizophrenia 24.94 10.52 356 1209769 21470 109357704
Jaundice cholestatic 24.89 10.52 257 1209868 14351 109364823
Pericardial haemorrhage 24.85 10.52 13 1210112 5204 109373970
Ductus arteriosus stenosis foetal 24.72 10.52 16 1210109 109 109379065
Head injury 24.60 10.52 327 1209798 42690 109336484
Hepatitis E 24.58 10.52 9 1210116 4450 109374724
Gene mutation 24.57 10.52 4 1210121 3425 109375749
Cardiovascular disorder 24.55 10.52 147 1209978 22613 109356561
Peritonitis 24.52 10.52 233 1209892 32374 109346800
Stomatitis 24.46 10.52 3345 1206780 266897 109112277
Dust allergy 24.37 10.52 18 1210107 5983 109373191
Viral haemorrhagic cystitis 24.28 10.52 4 1210121 3395 109375779
Mycobacterial infection 24.21 10.52 9 1210116 4408 109374766
Drug effective for unapproved indication 24.14 10.52 77 1210048 14090 109365084
Parkinsonism 24.09 10.52 143 1209982 22044 109357130
Rheumatoid factor positive 23.98 10.52 1711 1208414 129929 109249245
Gynaecomastia 23.83 10.52 42 1210083 9448 109369726
Product complaint 23.77 10.52 76 1210049 13896 109365278
Fracture 23.74 10.52 166 1209959 24622 109354552
Hepatitis B 23.72 10.52 43 1210082 9569 109369605
B-cell lymphoma 23.63 10.52 26 1210099 7128 109372046
Vascular stent thrombosis 23.62 10.52 8 1210117 4153 109375021
Partial seizures 23.59 10.52 56 1210069 11293 109367881
Atypical femur fracture 23.56 10.52 20 1210105 6199 109372975
Glomerular filtration rate decreased 23.48 10.52 203 1209922 28753 109350421
Electrocardiogram QT prolonged 23.42 10.52 964 1209161 107996 109271178
Delirium 23.40 10.52 1748 1208377 133277 109245897
Mycobacterium avium complex infection 23.39 10.52 18 1210107 5859 109373315
Self-medication 23.38 10.52 132 1209993 6100 109373074
Depression 23.37 10.52 3078 1207047 314257 109064917
Cachexia 23.36 10.52 69 1210056 12936 109366238
Ankylosing spondylitis 23.16 10.52 90 1210035 15522 109363652
Histoplasmosis disseminated 23.01 10.52 7 1210118 3892 109375282
Lymphoma 22.98 10.52 128 1209997 20043 109359131
Mite allergy 22.81 10.52 18 1210107 5785 109373389
Erysipelas 22.79 10.52 71 1210054 13087 109366087
Skin exfoliation 22.76 10.52 758 1209367 86893 109292281
Deep vein thrombosis postoperative 22.76 10.52 828 1209297 58463 109320711
Bilirubin urine present 22.73 10.52 23 1210102 315 109378859
Therapeutic response unexpected 22.67 10.52 160 1209965 23683 109355491
Brain stem glioma 22.66 10.52 19 1210106 201 109378973
Shock haemorrhagic 22.55 10.52 190 1209935 27057 109352117
Hip fracture 22.43 10.52 261 1209864 34890 109344284
Alpha tumour necrosis factor increased 22.33 10.52 25 1210100 387 109378787
Hypoglycaemia 22.32 10.52 1040 1209085 115064 109264110
Eyelid ptosis 22.32 10.52 73 1210052 13254 109365920
Long QT syndrome 22.29 10.52 27 1210098 7091 109372083
Pneumonia bacterial 22.24 10.52 182 1209943 26079 109353095
Petit mal epilepsy 22.21 10.52 30 1210095 7517 109371657
Hypothermia 22.19 10.52 408 1209717 25894 109353280
Altered state of consciousness 22.16 10.52 471 1209654 57155 109322019
Viral load increased 22.08 10.52 5 1210120 3385 109375789
Uterine cancer 22.06 10.52 9 1210116 4165 109375009
Fungal infection 22.03 10.52 407 1209718 50399 109328775
Therapeutic response decreased 21.99 10.52 848 1209277 95651 109283523
Epstein-Barr viraemia 21.91 10.52 6 1210119 3573 109375601
Osmolar gap 21.86 10.52 17 1210108 160 109379014
Gingival hypertrophy 21.83 10.52 10 1210115 4321 109374853
Cognitive disorder 21.81 10.52 1169 1208956 86342 109292832
Wound infection 21.77 10.52 1277 1208848 95188 109283986
Basal cell carcinoma 21.76 10.52 356 1209769 44914 109334260
Hepatic cirrhosis 21.76 10.52 568 1209557 67058 109312116
Metabolic disorder 21.73 10.52 52 1210073 10458 109368716
Secretion discharge 21.71 10.52 131 1209994 20113 109359061
Product preparation error 21.58 10.52 55 1210070 10824 109368350
Left ventricular failure 21.51 10.52 59 1210066 11330 109367844
Musculoskeletal stiffness 21.45 10.52 3431 1206694 276391 109102783
Aortic valve incompetence 21.41 10.52 56 1210069 10925 109368249
Concomitant disease aggravated 21.40 10.52 99 1210026 16265 109362909
Dry mouth 21.31 10.52 2500 1207625 197448 109181726
Serum sickness-like reaction 21.27 10.52 34 1210091 754 109378420
Ventricular hypokinesia 21.25 10.52 58 1210067 11156 109368018
Inflammatory marker increased 21.09 10.52 84 1210041 14385 109364789
Aortic valve stenosis 21.06 10.52 23 1210102 6327 109372847
Haematemesis 21.05 10.52 489 1209636 58619 109320555
Catheterisation cardiac 21.00 10.52 22 1210103 6169 109373005
SARS-CoV-2 test positive 20.89 10.52 280 1209845 16655 109362519
Exposure via inhalation 20.88 10.52 14 1210111 102 109379072
Neoplasm recurrence 20.85 10.52 16 1210109 5216 109373958
Tenosynovitis 20.82 10.52 271 1209854 16012 109363162
Injection site discomfort 20.79 10.52 27 1210098 6880 109372294
Systemic lupus erythematosus rash 20.76 10.52 59 1210066 1976 109377198
Blood creatinine increased 20.64 10.52 1721 1208404 181168 109198006
Asphyxia 20.51 10.52 242 1209883 13973 109365201
Carpal tunnel syndrome 20.40 10.52 154 1209971 22456 109356718
Analgesic therapy 20.39 10.52 30 1210095 7254 109371920
Fusarium infection 20.38 10.52 3 1210122 2768 109376406
Paresis 20.37 10.52 14 1210111 4830 109374344
Eosinophil percentage increased 20.35 10.52 50 1210075 1532 109377642
White coat hypertension 20.33 10.52 45 1210080 1286 109377888
Lymphadenopathy 20.32 10.52 537 1209588 63298 109315876
Cardiac tamponade 20.31 10.52 60 1210065 11247 109367927
Osteomyelitis 20.29 10.52 280 1209845 36320 109342854
Skin cancer 20.18 10.52 113 1210012 17671 109361503
Dermatitis 20.05 10.52 201 1209924 27636 109351538
Peripheral swelling 20.05 10.52 4848 1205277 399186 108979988
Dyslipidaemia 20.05 10.52 98 1210027 15867 109363307
Colon cancer 20.04 10.52 102 1210023 16341 109362833
Cryptococcosis 19.99 10.52 13 1210112 4618 109374556
Dry throat 19.98 10.52 171 1209954 9067 109370107
Ear infection 19.86 10.52 858 1209267 61874 109317300
Therapeutic product effect decreased 19.81 10.52 3005 1207120 241311 109137863
Injection site reaction 19.80 10.52 785 1209340 88285 109290889
Blood creatinine decreased 19.69 10.52 169 1209956 8968 109370206
Device deployment issue 19.67 10.52 11 1210114 4242 109374932
Injection site discolouration 19.66 10.52 44 1210081 9059 109370115
Cardiac operation 19.57 10.52 22 1210103 5973 109373201
Administration site swelling 19.52 10.52 29 1210096 602 109378572
Electric shock sensation 19.48 10.52 56 1210069 1888 109377286
Thyroiditis 19.47 10.52 26 1210099 6547 109372627
Ventricular tachycardia 19.45 10.52 408 1209717 49601 109329573
Monocyte chemotactic protein-1 increased 19.38 10.52 22 1210103 346 109378828
Monoparesis 19.36 10.52 13 1210112 4540 109374634
Potentiating drug interaction 19.34 10.52 64 1210061 11579 109367595
Systemic candida 19.34 10.52 51 1210074 9923 109369251
Intestinal obstruction 19.33 10.52 439 1209686 52788 109326386
Organising pneumonia 19.32 10.52 85 1210040 14158 109365016
Intracranial pressure increased 19.23 10.52 188 1209937 10347 109368827
Akinesia 19.23 10.52 8 1210117 3659 109375515
Blood potassium decreased 19.18 10.52 448 1209677 53666 109325508
Coronary artery occlusion 19.13 10.52 98 1210027 15674 109363500
Poor quality device used 19.10 10.52 4 1210121 2859 109376315
Autoimmune disorder 19.06 10.52 888 1209237 64595 109314579
Compartment syndrome 18.85 10.52 120 1210005 5790 109373384
Coronary artery bypass 18.83 10.52 23 1210102 6019 109373155
pH urine increased 18.81 10.52 24 1210101 429 109378745
Abortion induced 18.80 10.52 37 1210088 7982 109371192
Toxoplasmosis 18.79 10.52 6 1210119 3233 109375941
Concomitant disease progression 18.73 10.52 8 1210117 3602 109375572
Chronic gastrointestinal bleeding 18.61 10.52 25 1210100 471 109378703
Supraventricular tachycardia 18.58 10.52 174 1209951 24248 109354926
Muscle haemorrhage 18.55 10.52 29 1210096 6840 109372334
Vaginal haemorrhage 18.50 10.52 180 1209945 24894 109354280
Pseudomonas infection 18.49 10.52 205 1209920 27648 109351526
Portal hypertension 18.45 10.52 42 1210083 8595 109370579
Granulocytopenia 18.41 10.52 74 1210051 12641 109366533
Thinking abnormal 18.40 10.52 94 1210031 15046 109364128
Dyspnoea at rest 18.31 10.52 40 1210085 8306 109370868
Lung adenocarcinoma 18.28 10.52 49 1210076 9482 109369692
Immunosuppressant drug level decreased 18.22 10.52 4 1210121 2767 109376407
Dysgeusia 18.22 10.52 605 1209520 69380 109309794
Pneumocystis jirovecii infection 18.13 10.52 13 1210112 4387 109374787
Urinary casts 18.10 10.52 43 1210082 1289 109377885
Oesophageal candidiasis 18.08 10.52 65 1210060 11469 109367705
Immune effector cell-associated neurotoxicity syndrome 18.06 10.52 244 1209881 14538 109364636
Cardiac dysfunction 18.05 10.52 25 1210100 6198 109372976
Orthopnoea 18.02 10.52 61 1210064 10960 109368214
Invasive ductal breast carcinoma 18 10.52 28 1210097 6618 109372556
Type 2 diabetes mellitus 17.96 10.52 2209 1207916 175023 109204151
Product dispensing error 17.93 10.52 105 1210020 16240 109362934
Delusion of grandeur 17.91 10.52 60 1210065 2200 109376974
Psychiatric decompensation 17.91 10.52 22 1210103 5743 109373431
Pneumonia aspiration 17.82 10.52 717 1209408 80516 109298658
Glucose tolerance impaired 17.81 10.52 52 1210073 9785 109369389
Hypofibrinogenaemia 17.79 10.52 3 1210122 2504 109376670
Sputum culture positive 17.77 10.52 87 1210038 3802 109375372
Secondary immunodeficiency 17.76 10.52 15 1210110 4661 109374513
Haemorrhage intracranial 17.76 10.52 217 1209908 28752 109350422
Pleurothotonus 17.71 10.52 3 1210122 2495 109376679
Infusion site warmth 17.69 10.52 51 1210074 1722 109377452
Multiple drug therapy 17.68 10.52 149 1209976 7865 109371309
Adulterated product 17.58 10.52 39 1210086 1116 109378058
Atrioventricular block complete 17.55 10.52 138 1209987 19944 109359230
Coronary artery stenosis 17.54 10.52 84 1210041 13674 109365500
Dysphoria 17.49 10.52 27 1210098 6401 109372773
Polycystic ovaries 17.48 10.52 16 1210109 4780 109374394
Bradycardia 17.46 10.52 1464 1208661 154053 109225121
Victim of child abuse 17.44 10.52 40 1210085 1171 109378003
Symmetrical drug-related intertriginous and flexural exanthema 17.44 10.52 53 1210072 1844 109377330
Focal segmental glomerulosclerosis 17.40 10.52 12 1210113 4133 109375041
Granulomatosis with polyangiitis 17.35 10.52 80 1210045 3410 109375764
Local anaesthetic systemic toxicity 17.34 10.52 21 1210104 5516 109373658
Tongue pruritus 17.33 10.52 33 1210092 845 109378329
Hepatic cyst 17.32 10.52 37 1210088 7746 109371428
Scedosporium infection 17.32 10.52 3 1210122 2455 109376719
Glutathione decreased 17.29 10.52 10 1210115 54 109379120
Mast cell activation syndrome 17.27 10.52 46 1210079 1482 109377692
Pneumonia cytomegaloviral 17.26 10.52 31 1210094 6923 109372251
Euglycaemic diabetic ketoacidosis 17.24 10.52 67 1210058 11556 109367618
Device use issue 17.20 10.52 10 1210115 3774 109375400
Product label confusion 17.17 10.52 346 1209779 22331 109356843
Intermenstrual bleeding 17.13 10.52 31 1210094 6903 109372271
Adrenergic syndrome 17.10 10.52 18 1210107 259 109378915
Spinal operation 17.09 10.52 62 1210063 10910 109368264
Intervertebral discitis 17.07 10.52 133 1209992 6857 109372317
Aphasia 17.06 10.52 503 1209622 58494 109320680
Herpes zoster 17.00 10.52 991 1209134 107388 109271786
Nephrectomy 16.98 10.52 4 1210121 2636 109376538
Product physical issue 16.97 10.52 18 1210107 5018 109374156
Pupil fixed 16.93 10.52 85 1210040 3753 109375421
Dislocation of vertebra 16.88 10.52 611 1209514 43110 109336064
Embolism venous 16.87 10.52 18 1210107 5005 109374169
Peripheral venous disease 16.85 10.52 1102 1209023 83015 109296159
Sciatica 16.83 10.52 1201 1208924 91198 109287976
Chronic graft versus host disease in skin 16.78 10.52 4 1210121 2615 109376559
Mania 16.77 10.52 146 1209979 20650 109358524
Eye haemorrhage 16.75 10.52 69 1210056 11705 109367469
Lymphopenia 16.74 10.52 324 1209801 39846 109339328
Metabolic alkalosis 16.71 10.52 22 1210103 5573 109373601
Diabetic metabolic decompensation 16.67 10.52 11 1210114 3878 109375296
Toxic epidermal necrolysis 16.67 10.52 770 1209355 55957 109323217
Parvimonas micra infection 16.64 10.52 11 1210114 78 109379096
Amenorrhoea 16.57 10.52 49 1210076 9182 109369992
Confusional state 16.54 10.52 5545 1204580 463135 108916039
Genital haemorrhage 16.54 10.52 34 1210091 7218 109371956
Corneal oedema 16.51 10.52 7 1210118 3166 109376008
Psychotic symptom 16.50 10.52 11 1210114 3856 109375318
Hepatocellular injury 16.39 10.52 425 1209700 50217 109328957
Brain natriuretic peptide increased 16.38 10.52 65 1210060 11144 109368030
N-terminal prohormone brain natriuretic peptide increased 16.38 10.52 26 1210099 6095 109373079
Focal dyscognitive seizures 16.35 10.52 11 1210114 3838 109375336
Anxiety 16.33 10.52 4132 1205993 340946 109038228
Facial paresis 16.32 10.52 26 1210099 6087 109373087
Nasal necrosis 16.32 10.52 15 1210110 181 109378993
Sinus node dysfunction 16.25 10.52 48 1210077 8999 109370175
Sensitisation 16.16 10.52 13 1210112 4138 109375036
Band neutrophil percentage increased 16.14 10.52 21 1210104 383 109378791
Device defective 16.13 10.52 11 1210114 3811 109375363
Enteritis 16.11 10.52 133 1209992 19023 109360151
Brain abscess 16.10 10.52 31 1210094 6743 109372431
Cystic fibrosis pancreatic 16.10 10.52 9 1210116 45 109379129
Hiatus hernia 16.10 10.52 209 1209916 27397 109351777
Plasma cell myeloma recurrent 16.07 10.52 33 1210092 7009 109372165
Gastritis erosive 16.05 10.52 72 1210053 11928 109367246
Granulocyte count decreased 16.04 10.52 12 1210113 3962 109375212
Anaemia macrocytic 16.02 10.52 35 1210090 7268 109371906
Neoplasm malignant 15.96 10.52 298 1209827 36845 109342329
Blood triglycerides increased 15.92 10.52 176 1209949 23750 109355424
Chronic spontaneous urticaria 15.87 10.52 53 1210072 1940 109377234
Cells in urine 15.87 10.52 15 1210110 188 109378986
Hypoacusis 15.86 10.52 280 1209845 34911 109344263
Subarachnoid haemorrhage 15.83 10.52 229 1209896 29473 109349701
Diffuse large B-cell lymphoma refractory 15.80 10.52 62 1210063 2459 109376715
Peripheral artery occlusion 15.78 10.52 6 1210119 2899 109376275
Urine bilirubin decreased 15.77 10.52 13 1210112 134 109379040
Insulin-like growth factor increased 15.75 10.52 3 1210122 2293 109376881
Malignant melanoma 15.74 10.52 114 1210011 16777 109362397
Skin lesion 15.74 10.52 437 1209688 51194 109327980
Cyanosis neonatal 15.70 10.52 10 1210115 66 109379108
Infusion site haemorrhage 15.70 10.52 95 1210030 4503 109374671
High density lipoprotein decreased 15.67 10.52 24 1210101 5709 109373465
Epstein-Barr virus infection reactivation 15.64 10.52 13 1210112 4071 109375103
Lacunar infarction 15.62 10.52 28 1210097 6258 109372916
Anosognosia 15.56 10.52 13 1210112 4061 109375113
Treatment failure 15.56 10.52 2732 1207393 274502 109104672
Vascular rupture 15.52 10.52 50 1210075 1796 109377378
Renal transplant failure 15.48 10.52 5 1210120 2675 109376499
Unmasking of previously unidentified disease 15.46 10.52 6 1210119 2862 109376312
Catheter management 15.43 10.52 11 1210114 3724 109375450
Epilepsy 15.41 10.52 918 1209207 99291 109279883
Plasmacytoma 15.40 10.52 21 1210104 5241 109373933
Prothrombin time prolonged 15.36 10.52 270 1209855 16991 109362183
Device breakage 15.35 10.52 88 1210037 13681 109365493
Antemortem blood drug level abnormal 15.35 10.52 10 1210115 69 109379105
Exposure to SARS-CoV-2 15.32 10.52 68 1210057 2851 109376323
Cutaneous T-cell lymphoma 15.30 10.52 9 1210116 3375 109375799
Disseminated cryptococcosis 15.27 10.52 5 1210120 2652 109376522
Cystitis 15.25 10.52 876 1209249 65160 109314014
Inhibitory drug interaction 15.24 10.52 19 1210106 4928 109374246
Terminal state 15.23 10.52 24 1210101 5643 109373531
Injection site nodule 15.22 10.52 17 1210108 4629 109374545
Myocardial ischaemia 15.20 10.52 203 1209922 26481 109352693
Postoperative delirium 15.19 10.52 32 1210093 883 109378291
Coagulation factor X level decreased 15.19 10.52 11 1210114 92 109379082
Coagulation factor V level decreased 15.15 10.52 27 1210098 656 109378518
Thyroid cancer 15.15 10.52 28 1210097 6186 109372988
Nephrogenic diabetes insipidus 15.15 10.52 4 1210121 2441 109376733
Premature rupture of membranes 15.15 10.52 17 1210108 4620 109374554
Bradyarrhythmia 15.15 10.52 19 1210106 4915 109374259
Mucosal dryness 15.14 10.52 89 1210036 4174 109375000
Postmortem blood drug level abnormal 15.11 10.52 26 1210099 614 109378560
Hyperglycaemic hyperosmolar nonketotic syndrome 15.09 10.52 7 1210118 3002 109376172
Pollakiuria 15.08 10.52 368 1209757 43827 109335347
Injection site extravasation 15.06 10.52 174 1209951 9995 109369179
Product adhesion issue 15.06 10.52 7 1210118 2999 109376175
Neutrophilia 15.03 10.52 60 1210065 10269 109368905
Complication of device removal 15.03 10.52 17 1210108 4603 109374571
COVID-19 15.02 10.52 2970 1207155 242090 109137084
Mental status changes 15.02 10.52 996 1209129 75126 109304048
Nasal septum perforation 14.98 10.52 32 1210093 892 109378282
Diffuse large B-cell lymphoma 14.96 10.52 107 1210018 15791 109363383
Blindness 14.92 10.52 294 1209831 36065 109343109
Systemic mycosis 14.90 10.52 12 1210113 3817 109375357
Death 14.89 10.52 8128 1201997 690741 108688433
Mastocytosis 14.88 10.52 30 1210095 802 109378372
Blood pressure systolic decreased 14.87 10.52 218 1209907 13223 109365951
Gallbladder injury 14.79 10.52 39 1210086 1249 109377925
Atrioventricular block first degree 14.76 10.52 93 1210032 14132 109365042
Infusion related hypersensitivity reaction 14.75 10.52 31 1210094 854 109378320
Pre-eclampsia 14.75 10.52 47 1210078 8603 109370571
Metastasis 14.75 10.52 44 1210081 8223 109370951
Post-traumatic stress disorder 14.75 10.52 123 1210002 6473 109372701
Skin disorder 14.73 10.52 357 1209768 42556 109336618
Injection site urticaria 14.72 10.52 119 1210006 17096 109362078
Periorbital swelling 14.71 10.52 107 1210018 5398 109373776
Stenotrophomonas infection 14.64 10.52 26 1210099 5832 109373342
Ductus arteriosus premature closure 14.63 10.52 11 1210114 98 109379076
Dermatitis exfoliative 14.63 10.52 69 1210056 11278 109367896
Dementia 14.60 10.52 251 1209874 31422 109347752
Ejection fraction abnormal 14.55 10.52 10 1210115 3450 109375724
Brain scan abnormal 14.54 10.52 44 1210081 1527 109377647
Chronic gastritis 14.46 10.52 23 1210102 5388 109373786
Urticaria thermal 14.46 10.52 23 1210102 508 109378666
Allergy test negative 14.38 10.52 20 1210105 390 109378784
Swollen tongue 14.38 10.52 803 1209322 59559 109319615
Acute graft versus host disease in liver 14.36 10.52 4 1210121 2355 109376819
Substance use disorder 14.35 10.52 37 1210088 7253 109371921
Enterobacter infection 14.34 10.52 26 1210099 5785 109373389
Device related infection 14.33 10.52 326 1209799 39193 109339981
Knee operation 14.32 10.52 35 1210090 6987 109372187
Thirst 14.31 10.52 160 1209965 21547 109357627
Staphylococcal sepsis 14.31 10.52 122 1210003 17332 109361842
Carotid artery occlusion 14.28 10.52 55 1210070 9510 109369664
Band neutrophil count increased 14.27 10.52 27 1210098 688 109378486
Unintended pregnancy 14.26 10.52 19 1210106 4789 109374385
Blood potassium increased 14.21 10.52 267 1209858 32982 109346192
Anger 14.21 10.52 136 1209989 18871 109360303
Extrapyramidal disorder 14.21 10.52 226 1209899 28641 109350533
Paraplegia 14.20 10.52 29 1210096 6171 109373003
Device delivery system issue 14.19 10.52 3 1210122 2130 109377044
Tri-iodothyronine free increased 14.18 10.52 16 1210109 250 109378924
Swelling face 14.17 10.52 1184 1208941 91137 109288037
Escherichia sepsis 14.12 10.52 61 1210064 10211 109368963
Application site pain 14.11 10.52 24 1210101 5475 109373699
Maternal exposure timing unspecified 14.09 10.52 315 1209810 20698 109358476
Enthesopathy 14.05 10.52 203 1209922 12275 109366899
Chondropathy 14.04 10.52 7 1210118 2880 109376294
Atrial flutter 14.03 10.52 184 1209941 24078 109355096
Disseminated intravascular coagulation 14.03 10.52 344 1209781 40942 109338232
Complication associated with device 14.02 10.52 146 1209979 19927 109359247
Nephrogenic systemic fibrosis 14.01 10.52 24 1210101 5459 109373715
Coagulation factor decreased 13.97 10.52 18 1210107 325 109378849
Administration site bruise 13.97 10.52 15 1210110 221 109378953
Infusion site streaking 13.97 10.52 24 1210101 566 109378608
Groin pain 13.96 10.52 105 1210020 15323 109363851
Tooth infection 13.96 10.52 330 1209795 21886 109357288
White blood cells urine 13.95 10.52 22 1210103 482 109378692
Hypercalcaemia 13.94 10.52 396 1209729 46261 109332913
Metastases to peritoneum 13.93 10.52 25 1210100 5585 109373589
Vitamin K deficiency 13.91 10.52 31 1210094 890 109378284
Varices oesophageal 13.91 10.52 37 1210088 7178 109371996
Tachypnoea 13.88 10.52 545 1209580 38850 109340324
Tooth injury 13.88 10.52 55 1210070 2191 109376983
Device failure 13.86 10.52 37 1210088 7170 109372004
Cerebral aspergillosis 13.83 10.52 4 1210121 2298 109376876
Psychomotor skills impaired 13.75 10.52 36 1210089 7022 109372152
Sudden death 13.75 10.52 186 1209939 24209 109354965
Fanconi syndrome 13.73 10.52 11 1210114 3508 109375666
Thoracic vertebral fracture 13.70 10.52 33 1210092 6622 109372552
Disseminated aspergillosis 13.68 10.52 5 1210120 2475 109376699
Alcoholic coma 13.68 10.52 10 1210115 85 109379089
Low density lipoprotein increased 13.67 10.52 65 1210060 10601 109368573
Hip surgery 13.65 10.52 15 1210110 4115 109375059
Diabetic nephropathy 13.64 10.52 11 1210114 3497 109375677
Lung transplant 13.63 10.52 23 1210102 5263 109373911
Idiopathic pulmonary fibrosis 13.63 10.52 21 1210104 4983 109374191
Adjustment disorder with depressed mood 13.62 10.52 599 1209526 43284 109335890
Arterial haemorrhage 13.61 10.52 13 1210112 3806 109375368
Dermatitis allergic 13.59 10.52 162 1209963 21562 109357612
Eye irritation 13.58 10.52 271 1209854 33181 109345993
Limb mass 13.55 10.52 82 1210043 3887 109375287
Drug provocation test 13.54 10.52 7 1210118 29 109379145
Perfume sensitivity 13.52 10.52 34 1210091 1057 109378117
Lower gastrointestinal haemorrhage 13.52 10.52 133 1209992 18353 109360821
Acute psychosis 13.52 10.52 21 1210104 4966 109374208
Urobilinogen urine increased 13.51 10.52 25 1210100 626 109378548
Neonatal respiratory acidosis 13.48 10.52 9 1210116 65 109379109
Viraemia 13.45 10.52 15 1210110 4087 109375087
Nutritional supplementation 13.44 10.52 8 1210117 46 109379128
Oedema 13.43 10.52 2054 1208071 207922 109171252
Diabetic neuropathy 13.41 10.52 36 1210089 6963 109372211
Infusion site nodule 13.40 10.52 20 1210105 417 109378757
Fungal rhinitis 13.40 10.52 10 1210115 88 109379086
Goitre 13.39 10.52 30 1210095 6174 109373000
Injury associated with device 13.37 10.52 17 1210108 4372 109374802
Haemorrhagic diathesis 13.37 10.52 40 1210085 7468 109371706
Therapy change 13.36 10.52 60 1210065 9937 109369237
Personality disorder 13.35 10.52 206 1209919 12631 109366543
SJS-TEN overlap 13.33 10.52 48 1210077 1826 109377348
Clonus 13.30 10.52 150 1209975 8566 109370608
Stent placement 13.27 10.52 38 1210087 7196 109371978
Mean cell haemoglobin concentration decreased 13.26 10.52 107 1210018 5575 109373599
Intentional dose omission 13.24 10.52 148 1209977 19932 109359242
Allergy to immunoglobulin therapy 13.24 10.52 12 1210113 142 109379032
Post cholecystectomy syndrome 13.23 10.52 29 1210096 823 109378351
Urosepsis 13.22 10.52 246 1209879 30429 109348745
Dialysis 13.18 10.52 144 1209981 19475 109359699
Amniotic cavity disorder 13.17 10.52 8 1210117 48 109379126
Anti-erythrocyte antibody positive 13.16 10.52 9 1210116 68 109379106
Tendon rupture 13.13 10.52 95 1210030 13983 109365191
Blood glucose abnormal 13.12 10.52 85 1210040 12831 109366343
Gastrointestinal toxicity 13.11 10.52 70 1210055 11078 109368096
Lymphocyte count abnormal 13.10 10.52 57 1210068 2369 109376805
Gastritis 13.10 10.52 468 1209657 53231 109325943
Lung carcinoma cell type unspecified stage IV 13.10 10.52 4 1210121 2218 109376956
Nephrotic syndrome 13.06 10.52 93 1210032 13738 109365436
Peripheral sensory neuropathy 13.05 10.52 118 1210007 16562 109362612
Tongue biting 13.03 10.52 8 1210117 2931 109376243
Splenomegaly 13.02 10.52 189 1209936 24309 109354865
Emotional distress 13.02 10.52 608 1209517 44239 109334935
Vital capacity decreased 13.00 10.52 51 1210074 2022 109377152
Lipaemic index score 13.00 10.52 11 1210114 118 109379056
Gastroenteritis 12.99 10.52 324 1209801 38476 109340698
Breast cancer stage IV 12.95 10.52 3 1210122 2000 109377174
Atrioventricular block 12.95 10.52 120 1210005 16757 109362417
Muscle spasms 12.92 10.52 2768 1207357 275389 109103785
Total lung capacity increased 12.89 10.52 98 1210027 5014 109374160
Joint laxity 12.86 10.52 58 1210067 2449 109376725
Prerenal failure 12.84 10.52 18 1210107 4441 109374733
Eye swelling 12.80 10.52 462 1209663 32586 109346588
Mononeuropathy 12.79 10.52 18 1210107 355 109378819
Galactorrhoea 12.76 10.52 16 1210109 4139 109375035
Movement disorder 12.73 10.52 302 1209823 36102 109343072
Apparent death 12.73 10.52 8 1210117 2894 109376280
No adverse event 12.71 10.52 669 1209456 73170 109306004
Toothache 12.69 10.52 343 1209782 23232 109355942
Rhinalgia 12.67 10.52 80 1210045 3849 109375325
Prostatic pain 12.67 10.52 16 1210109 283 109378891
Finger deformity 12.67 10.52 462 1209663 32630 109346544
Carotid arteriosclerosis 12.64 10.52 9 1210116 3048 109376126
Autoimmune haemolytic anaemia 12.62 10.52 66 1210059 10501 109368673
Atypical mycobacterial infection 12.62 10.52 7 1210118 2711 109376463
Muscle atrophy 12.57 10.52 89 1210036 13165 109366009
Escherichia infection 12.56 10.52 184 1209941 23632 109355542
Parvovirus B19 infection 12.56 10.52 8 1210117 2873 109376301
Internal haemorrhage 12.54 10.52 62 1210063 10009 109369165
Device occlusion 12.51 10.52 106 1210019 15079 109364095
Osteolysis 12.51 10.52 26 1210099 5497 109373677
Head discomfort 12.48 10.52 284 1209841 18716 109360458
Immune-mediated myositis 12.48 10.52 31 1210094 6155 109373019
Bone lesion 12.44 10.52 38 1210087 7049 109372125
Pulmonary toxicity 12.43 10.52 129 1209996 17617 109361557
Neurologic neglect syndrome 12.42 10.52 156 1209969 9142 109370032
Child abuse 12.41 10.52 29 1210096 860 109378314
Hypovolaemic shock 12.38 10.52 101 1210024 14482 109364692
Pulmonary mucormycosis 12.38 10.52 4 1210121 2139 109377035
Infusion site oedema 12.36 10.52 40 1210085 1440 109377734
Periorbital oedema 12.36 10.52 168 1209957 10024 109369150
Urine bilirubin increased 12.35 10.52 11 1210114 127 109379047
Atrial tachycardia 12.31 10.52 55 1210070 9123 109370051
Malnutrition 12.31 10.52 217 1209908 27062 109352112
Foreign body sensation in eyes 12.29 10.52 11 1210114 3323 109375851
Harlequin syndrome 12.28 10.52 15 1210110 256 109378918
Ventricular fibrillation 12.25 10.52 351 1209774 40962 109338212
Vital functions abnormal 12.22 10.52 33 1210092 1072 109378102
Consciousness fluctuating 12.17 10.52 52 1210073 2144 109377030
Hyperuricaemia 12.17 10.52 101 1210024 14430 109364744
Soft tissue disorder 12.15 10.52 73 1210052 3451 109375723
Neck surgery 12.14 10.52 4 1210121 2113 109377061
Acid-base balance disorder mixed 12.14 10.52 10 1210115 103 109379071
Catheter site pruritus 12.14 10.52 5 1210120 2301 109376873
Colitis 12.13 10.52 959 1209166 101364 109277810
Generalised tonic-clonic seizure 12.13 10.52 482 1209643 54198 109324976
Intestinal perforation 12.05 10.52 159 1209966 20785 109358389
Azotaemia 12.04 10.52 63 1210062 10022 109369152
Disorientation 12.04 10.52 641 1209484 70030 109309144
Cor pulmonale 12.04 10.52 5 1210120 2289 109376885
Infusion site scar 12.03 10.52 19 1210106 417 109378757
Vitreous haemorrhage 12.01 10.52 20 1210105 4600 109374574
Patient uncooperative 11.99 10.52 30 1210095 930 109378244
Hypoaesthesia 11.98 10.52 3729 1206396 310494 109068680
Fluid retention 11.95 10.52 879 1209246 93428 109285746
Acute fatty liver of pregnancy 11.93 10.52 7 1210118 39 109379135
Diastolic dysfunction 11.91 10.52 83 1210042 12321 109366853
Renal failure neonatal 11.90 10.52 9 1210116 81 109379093
PCO2 decreased 11.89 10.52 67 1210058 3094 109376080
Blood pressure decreased 11.86 10.52 1436 1208689 113655 109265519
Granulocyte count increased 11.81 10.52 48 1210077 1935 109377239
Pancreatic carcinoma metastatic 11.80 10.52 17 1210108 4147 109375027
Febrile infection 11.80 10.52 19 1210106 4429 109374745
Haemorrhoidal haemorrhage 11.78 10.52 47 1210078 8046 109371128
Adverse reaction 11.78 10.52 415 1209710 29179 109349995
Anal ulcer 11.76 10.52 3 1210122 1873 109377301
Fluid replacement 11.73 10.52 30 1210095 943 109378231
Pneumothorax 11.71 10.52 295 1209830 34990 109344184
Cardiac output decreased 11.71 10.52 4 1210121 2065 109377109
Blood immunoglobulin G decreased 11.70 10.52 100 1210025 5300 109373874
Blood glucose fluctuation 11.66 10.52 44 1210081 7654 109371520
Diarrhoea haemorrhagic 11.65 10.52 112 1210013 15527 109363647
Cerebellar syndrome 11.64 10.52 33 1210092 6269 109372905
Right ventricle outflow tract obstruction 11.64 10.52 8 1210117 61 109379113
Specific gravity urine abnormal 11.64 10.52 9 1210116 84 109379090
Bradycardia neonatal 11.64 10.52 9 1210116 84 109379090
Sneezing 11.63 10.52 444 1209681 31540 109347634
Neutropenic sepsis 11.62 10.52 252 1209873 30494 109348680
Arthritis bacterial 11.61 10.52 70 1210055 10750 109368424
Neuroblastoma 11.58 10.52 17 1210108 349 109378825
Left ventricular hypertrophy 11.58 10.52 91 1210034 13153 109366021
Crystal nephropathy 11.57 10.52 3 1210122 1853 109377321
Renal tubular disorder 11.56 10.52 42 1210083 7387 109371787
Incorrect dosage administered 11.55 10.52 78 1210047 3840 109375334
Retinal deposits 11.51 10.52 11 1210114 140 109379034
Generalised oedema 11.50 10.52 252 1209873 30452 109348722
Sphincter of Oddi dysfunction 11.48 10.52 22 1210103 566 109378608
Faecaloma 11.43 10.52 106 1210019 14802 109364372
Oesophageal varices haemorrhage 11.43 10.52 23 1210102 4922 109374252
Opiates positive 11.37 10.52 29 1210096 910 109378264
Mean cell haemoglobin concentration increased 11.34 10.52 32 1210093 1067 109378107
Withdrawal syndrome 11.34 10.52 259 1209866 31121 109348053
Mood altered 11.32 10.52 165 1209960 21210 109357964
Extremity necrosis 11.30 10.52 15 1210110 3787 109375387
Feeling abnormal 11.30 10.52 1770 1208355 178941 109200233
Low turnover osteopathy 11.28 10.52 4 1210121 2018 109377156
Gingival bleeding 11.27 10.52 151 1209974 19688 109359486
Stenosis 11.27 10.52 12 1210113 3339 109375835
Cerebral artery thrombosis 11.26 10.52 42 1210083 1626 109377548
Oesophagitis 11.24 10.52 234 1209891 28481 109350693
Ileal ulcer 11.21 10.52 3 1210122 1814 109377360
Pneumonia viral 11.20 10.52 178 1209947 10979 109368195
Teething 11.20 10.52 11 1210114 145 109379029
Fanconi syndrome acquired 11.20 10.52 10 1210115 3024 109376150
Immune-mediated hypothyroidism 11.20 10.52 9 1210116 2866 109376308
Thrombotic thrombocytopenic purpura 11.20 10.52 40 1210085 7071 109372103
Onychomadesis 11.18 10.52 609 1209516 45054 109334120
Impulse-control disorder 11.16 10.52 5 1210120 2189 109376985
Infusion site discharge 11.15 10.52 47 1210078 1926 109377248
Anaphylactoid reaction 11.12 10.52 119 1210006 6707 109372467
Liver transplant rejection 11.10 10.52 16 1210109 3902 109375272
Dystonia 11.10 10.52 207 1209918 25598 109353576
Allergic reaction to excipient 11.08 10.52 26 1210099 773 109378401
IgA nephropathy 11.08 10.52 11 1210114 3162 109376012
Gastrointestinal perforation 11.05 10.52 43 1210082 7413 109371761
Stress cardiomyopathy 11.03 10.52 115 1210010 15691 109363483
Gastric haemorrhage 11.02 10.52 116 1210009 15799 109363375
Bradyphrenia 11.01 10.52 79 1210046 11649 109367525
Antiphospholipid syndrome 11.00 10.52 7 1210118 2516 109376658
Atrioventricular block second degree 10.99 10.52 49 1210076 8132 109371042
Haemorrhage subcutaneous 10.99 10.52 28 1210097 5511 109373663
Polydipsia 10.97 10.52 45 1210080 7643 109371531
Akathisia 10.95 10.52 127 1209998 16986 109362188
Pulmonary function test abnormal 10.94 10.52 24 1210101 4976 109374198
Hyperparathyroidism secondary 10.92 10.52 12 1210113 3292 109375882
Disorganised speech 10.91 10.52 12 1210113 3291 109375883
Multiple sclerosis relapse 10.90 10.52 444 1209681 49796 109329378
Mental disorder 10.90 10.52 332 1209793 38459 109340715
Thyroid neoplasm 10.90 10.52 12 1210113 3289 109375885
Alpha 1 microglobulin increased 10.90 10.52 7 1210118 47 109379127
Dysuria 10.89 10.52 543 1209582 59688 109319486
Meniscus injury 10.88 10.52 46 1210079 7747 109371427
Drug-disease interaction 10.85 10.52 46 1210079 1890 109377284
Skin weeping 10.84 10.52 15 1210110 3720 109375454
Anal fissure 10.83 10.52 160 1209965 9721 109369453
Breast cancer stage III 10.80 10.52 1006 1209119 78111 109301063
Blood immunoglobulin A decreased 10.79 10.52 51 1210074 2197 109376977
Loss of libido 10.78 10.52 11 1210114 3122 109376052
Vessel puncture site bruise 10.78 10.52 20 1210105 502 109378672
Post procedural haemorrhage 10.76 10.52 113 1210012 15399 109363775
Paraesthesia oral 10.76 10.52 461 1209664 33210 109345964
Abnormal behaviour 10.75 10.52 335 1209790 38704 109340470
Band sensation 10.75 10.52 31 1210094 1047 109378127
Grip strength decreased 10.73 10.52 1018 1209107 79156 109300018
Lip swelling 10.73 10.52 667 1209458 50000 109329174
Acinetobacter infection 10.72 10.52 14 1210111 3559 109375615
Delusion 10.71 10.52 189 1209936 23566 109355608
Neonatal respiratory distress syndrome 10.70 10.52 17 1210108 375 109378799
Adenocarcinoma 10.69 10.52 19 1210106 4261 109374913
Abdominal pain upper 10.69 10.52 4109 1206016 345002 109034172
Sleep apnoea syndrome 10.68 10.52 349 1209776 40098 109339076
Red blood cells urine 10.68 10.52 23 1210102 645 109378529
Oxygen saturation abnormal 10.67 10.52 101 1210024 5510 109373664
Lymphangiosis carcinomatosa 10.67 10.52 7 1210118 2475 109376699
Haemolysis 10.67 10.52 235 1209890 15404 109363770
Ear swelling 10.65 10.52 49 1210076 2087 109377087
Ototoxicity 10.63 10.52 18 1210107 4113 109375061
Vein collapse 10.63 10.52 35 1210090 1272 109377902
Hallucination 10.62 10.52 960 1209165 100472 109278702
Porphyria acute 10.62 10.52 275 1209850 18505 109360669
Respiratory rate decreased 10.62 10.52 110 1210015 6148 109373026
Gastric fluid analysis abnormal 10.58 10.52 3 1210122 0 109379174
Central auditory processing disorder 10.58 10.52 3 1210122 0 109379174
Behaviour disorder 10.57 10.52 62 1210063 9585 109369589
Alanine aminotransferase abnormal 10.57 10.52 152 1209973 9182 109369992
Mental impairment 10.57 10.52 179 1209946 22460 109356714
Osteopenia 10.56 10.52 175 1209950 22034 109357140
Ophthalmoplegia 10.56 10.52 14 1210111 3536 109375638
Metastases to skin 10.56 10.52 6 1210119 2293 109376881

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Accidental overdose 25.27 17.20 14 679 136 113124
Gastrointestinal necrosis 19.06 17.20 9 684 60 113200
Incorrect route of product administration 18.85 17.20 6 687 10 113250

Pharmacologic Action:

SourceCodeDescription
ATC D04AA32 DERMATOLOGICALS
ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
Antihistamines for topical use
ATC M01AE57 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
ATC R06AA02 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Aminoalkyl ethers
ATC R06AA52 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Aminoalkyl ethers
FDA MoA N0000000190 Histamine H1 Receptor Antagonists
MeSH PA D000068776 Sleep Aids, Pharmaceutical
MeSH PA D000777 Anesthetics
MeSH PA D000779 Anesthetics, Local
MeSH PA D000932 Antiemetics
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018926 Anti-Allergic Agents
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35717 sedative
CHEBI has role CHEBI:36333 local anaesthetic
CHEBI has role CHEBI:37955 H<small><sub>1</sub></small>-receptor antagonist
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50857 anti-allergic agent
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:59683 antipruritic drug
CHEBI has role CHEBI:64951 anti-HBV agent
CHEBI has role CHEBI:66956 antidyskinesia agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:146270 oneirogen
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:233423 antifibrotic agent
FDA EPC N0000175587 Histamine-1 Receptor Antagonist

Related Drugs by ATC class:

D04AA Antihistamines for topical use 13 drugs
bamipinechloropyraminechlorphenoxamineclemastinedimetindeneisothipendylmepyraminepheniraminepromethazinethenalidinethonzylaminetolpropamine show all 13 →
M01AE Propionic acid derivatives 21 drugs
alminoprofenbenoxaprofendexibuprofendexketoprofenesomeprazolefenbufenfenoprofenflunoxaprofenflurbiprofenibuprofenibuproxamindoprofen show all 21 →
R06AA Aminoalkyl ethers 8 drugs
bromazinecarbinoxaminechlorphenoxamineclemastinedimenhydrinatediphenylpyralinedoxylaminetrimethobenzamide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vasomotor rhinitis indication 8229003 DOID:4730
Insomnia indication 193462001
Seasonal allergic rhinitis indication 367498001
Allergic conjunctivitis indication 473460002 DOID:11204
Migraine off-label use 37796009 DOID:6364
Anxiety disorder off-label use 197480006 DOID:2030
Local anesthesia off-label use 386761002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.52 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 7.81 WOMBAT-PK CHEMBL
Sodium-dependent noradrenaline transporter Transporter Kd 6.02 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 6.43 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 6.15 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.29 DRUG MATRIX
Histamine H4 receptor GPCR Ki 4.37 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 7 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 6.92 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR Ki 6.64 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 6.95 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 6.59 WOMBAT-PK
Cytochrome P450 2D6 Enzyme Ki 4.93 WOMBAT-PK
Solute carrier family 22 member 2 Transporter IC50 4.68 WOMBAT-PK
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 5.22 CHEMBL
Sodium-dependent serotonin transporter Transporter Kd 5.42 SCIENTIFIC LITERATURE
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.59 CHEMBL
Sodium-dependent dopamine transporter Transporter Kd 5.66 SCIENTIFIC LITERATURE
Histamine H1 receptor GPCR IC50 9 CHEMBL

External reference:

IDSource
4019724 VUID
N0000147816 NUI
D00300 KEGG_DRUG
7491-10-3 SECONDARY_CAS_RN
103659-13-8 SECONDARY_CAS_RN
147-24-0 SECONDARY_CAS_RN
88637-37-0 SECONDARY_CAS_RN
1362 RXNORM
4017866 VANDF
4019724 VANDF
4020653 VANDF
C0012522 UMLSCUI
CHEBI:4636 CHEBI
2PM PDB_CHEM_ID
CHEMBL657 ChEMBL_ID
CHEMBL1620 ChEMBL_ID
CHEMBL1201089 ChEMBL_ID
DB01075 DRUGBANK_ID
D004155 MESH_DESCRIPTOR_UI
3100 PUBCHEM_CID
1224 IUPHAR_LIGAND_ID
1774 INN_ID
8GTS82S83M UNII
14992 MMSL
1676 MMSL
4611 MMSL
4612 MMSL
899 MMSL
d00212 MMSL
003369 NDDF
004787 NDDF
005115 NDDF
19510001 SNOMEDCT_US
26458009 SNOMEDCT_US
372682005 SNOMEDCT_US
62481000087103 SNOMEDCT_US
8GTS82S83M INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Robitussin Maximum Strength Severe Multi-Symptom Cough Cold Flu Nighttime HUMAN OTC DRUG LABEL 2 0031-0101 LIQUID 25 mg ORAL OTC Monograph Drug 17 sections
Robitussin Severe Multi-Symptom Cough Cold Flu Nighttime HUMAN OTC DRUG LABEL 3 0031-8752 SOLUTION 25 mg ORAL OTC Monograph Drug 17 sections
Robitussin Honey Severe Cough, Flu Plus Sore Throat Nighttime HUMAN OTC DRUG LABEL 2 0031-8770 SOLUTION 25 mg ORAL OTC Monograph Drug 17 sections
Theraflu Severe Cold Relief Nighttime HUMAN OTC DRUG LABEL 2 0067-0101 POWDER, FOR SOLUTION 25 mg ORAL OTC Monograph Drug 17 sections
Theraflu Severe Cold Relief Nighttime HUMAN OTC DRUG LABEL 2 0067-0105 SYRUP 25 mg ORAL OTC Monograph Drug 16 sections
Theraflu Severe Cold Relief Nighttime Soft Chews HUMAN OTC DRUG LABEL 2 0067-0112 TABLET, CHEWABLE 12.50 mg ORAL OTC Monograph Drug 16 sections
Excedrin PM Triple Action Caplets HUMAN OTC DRUG LABEL 3 0067-2056 TABLET, COATED 38 mg ORAL OTC Monograph Drug 16 sections
THERAFLU POWERPODS NIGHTTIME SEVERE COLD HUMAN OTC DRUG LABEL 3 0067-6095 POWDER, FOR SOLUTION 25 mg ORAL OTC Monograph Drug 16 sections
Theraflu Severe Cold relief Nighttime HUMAN OTC DRUG LABEL 3 0067-6801 POWDER 25 mg ORAL OTC Monograph Drug 17 sections
Theraflu Severe Cold Relief Nighttime HUMAN OTC DRUG LABEL 3 0067-6803 POWDER, FOR SOLUTION 25 mg ORAL OTC Monograph Drug 16 sections
THERAFLU NIGHTTIME SEVERE COLD AND COUGH HUMAN OTC DRUG LABEL 3 0067-7918 POWDER, FOR SOLUTION 25 mg ORAL OTC Monograph Drug 17 sections
Theraflu ExpressMax Nighttime Severe Cold and Cough HUMAN OTC DRUG LABEL 3 0067-8129 SYRUP 25 mg ORAL OTC Monograph Drug 16 sections
Theraflu ExpressMax Nighttime Severe Cold and Cough HUMAN OTC DRUG LABEL 3 0067-8137 TABLET, FILM COATED 12.50 mg ORAL OTC Monograph Drug 16 sections
Theraflu Severe Cold Relief Nighttime with Honey Elderberry Flavor HUMAN OTC DRUG LABEL 3 0067-8212 POWDER, FOR SOLUTION 25 mg ORAL OTC Monograph Drug 17 sections
good sense ibuprofen pm HUMAN OTC DRUG LABEL 2 0113-0050 TABLET, FILM COATED 38 mg ORAL ANDA 16 sections
Good Sense Sleep Time HUMAN OTC DRUG LABEL 1 0113-0186 SOLUTION 50 mg ORAL OTC Monograph Drug 16 sections
good sense allergy HUMAN OTC DRUG LABEL 1 0113-0379 SOLUTION 12.50 mg ORAL OTC Monograph Drug 14 sections
good sense nighttime sleep aid HUMAN OTC DRUG LABEL 1 0113-0431 TABLET, FILM COATED 25 mg ORAL OTC Monograph Drug 16 sections
good sense pain relief pmextra strength HUMAN OTC DRUG LABEL 2 0113-0437 TABLET, FILM COATED 25 mg ORAL OTC Monograph Drug 16 sections
good sense allergy relief HUMAN OTC DRUG LABEL 1 0113-0479 TABLET 25 mg ORAL OTC Monograph Drug 15 sections
good sense itch relief HUMAN OTC DRUG LABEL 2 0113-0622 CREAM 2 g TOPICAL OTC Monograph Drug 14 sections
good sense naproxen sodium HUMAN OTC DRUG LABEL 2 0113-8264 TABLET, FILM COATED 25 mg ORAL ANDA 16 sections
DIPHENHYDRAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0489 SOLUTION 12.50 mg ORAL ANDA 20 sections
Diphenhydramine HCl HUMAN OTC DRUG LABEL 1 0121-0865 SOLUTION 12.50 mg ORAL OTC Monograph Drug 14 sections
DIPHENHYDRAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0978 SOLUTION 25 mg ORAL ANDA 20 sections
Diphenhydramine HCl HUMAN OTC DRUG LABEL 1 0121-1730 SOLUTION 25 mg ORAL OTC Monograph Drug 14 sections
PANADOL PM HUMAN OTC DRUG LABEL 2 0135-0608 TABLET, FILM COATED 25 mg ORAL OTC Monograph Drug 18 sections
PANADOL PM HUMAN OTC DRUG LABEL 2 0135-7021 TABLET, FILM COATED 25 mg ORAL OTC Monograph Drug 19 sections
Aleve PM HUMAN OTC DRUG LABEL 2 0280-1200 TABLET, FILM COATED 25 mg ORAL NDA 17 sections
Childrens WAL-DRYLSingle-Use Allergy HUMAN OTC DRUG LABEL 1 0363-0004 LIQUID 12.50 mg ORAL OTC MONOGRAPH FINAL 16 sections