meldonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3995 76144-81-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mildronate
  • quaterin
  • meldonium
structural analog of gamma-butyrobetaine, also of carnitine; antianginal compound; MET-88 is dihydrate; structure given in first source
  • Molecular weight: 146.19
  • Formula: C6H14N2O2
  • CLOGP: -2.22
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 52.16
  • ALOGS: -0.99
  • ROTB: 4

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.80 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 6.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01EB22 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
OTHER CARDIAC PREPARATIONS
Other cardiac preparations
MeSH PA D000276 Adjuvants, Immunologic
MeSH PA D002317 Cardiovascular Agents
MeSH PA D007155 Immunologic Factors
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:77307 cardioprotective agents
CHEBI has role CHEBI:131844 4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.14 acidic
pKa2 9.75 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Gamma-butyrobetaine dioxygenase Enzyme Ki 4.80 CHEMBL

External reference:

IDSource
D10504 KEGG_DRUG
CHEBI:131843 CHEBI
REE PDB_CHEM_ID
CHEMBL2104708 ChEMBL_ID
C050147 MESH_SUPPLEMENTAL_RECORD_UI
8180 INN_ID
DB13723 DRUGBANK_ID
73H7UDN6EC UNII
123868 PUBCHEM_CID
C0047115 UMLSCUI

Pharmaceutical products:

None