Stem definition | Drug id | CAS RN |
---|---|---|
anti-inflammatory agents, ibufenac derivatives | 865 | 15307-86-5 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
0.10 | g | P |
0.10 | g | R |
0.10 | g | O |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 10.85 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Hosey CM, Chan R, Benet LZ |
S (Water solubility) | 0.14 mg/mL | Hosey CM, Chan R, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Hosey CM, Chan R, Benet LZ |
BA (Bioavailability) | 54 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.22 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 28, 1988 | FDA | ||
March 23, 2021 | PMDA | Hisamitsu Pharmaceutical Co., Inc |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pemphigus | 2158.97 | 10.04 | 3144 | 261399 | 154068 | 55873456 |
Glossodynia | 2039.78 | 10.04 | 3012 | 261531 | 149446 | 55878078 |
Systemic lupus erythematosus | 1921.06 | 10.04 | 3206 | 261337 | 176872 | 55850652 |
Hand deformity | 1763.74 | 10.04 | 2633 | 261910 | 131859 | 55895665 |
Wound | 1592.51 | 10.04 | 2555 | 261988 | 136249 | 55891275 |
Pericarditis | 1551.59 | 10.04 | 2218 | 262325 | 106705 | 55920819 |
Abdominal discomfort | 1480.69 | 10.04 | 3705 | 260838 | 273569 | 55753955 |
Discomfort | 1476.06 | 10.04 | 2498 | 262045 | 139263 | 55888261 |
Arthropathy | 1373.60 | 10.04 | 2954 | 261589 | 197321 | 55830203 |
Anti-cyclic citrullinated peptide antibody positive | 1370.64 | 10.04 | 1985 | 262558 | 96615 | 55930909 |
Alopecia | 1129.54 | 10.04 | 3481 | 261062 | 289977 | 55737547 |
Rheumatoid arthritis | 1040.66 | 10.04 | 4043 | 260500 | 378561 | 55648963 |
Swelling | 1032.96 | 10.04 | 2961 | 261582 | 236810 | 55790714 |
Synovitis | 1023.20 | 10.04 | 2307 | 262236 | 158998 | 55868526 |
Duodenal ulcer perforation | 1014.20 | 10.04 | 1420 | 263123 | 66922 | 55960602 |
Contraindicated product administered | 976.44 | 10.04 | 2474 | 262069 | 183812 | 55843712 |
Helicobacter infection | 937.00 | 10.04 | 1419 | 263124 | 71849 | 55955675 |
Maternal exposure during pregnancy | 886.77 | 10.04 | 2413 | 262130 | 187140 | 55840384 |
Infusion related reaction | 800.27 | 10.04 | 2476 | 262067 | 206455 | 55821069 |
Hepatic enzyme increased | 799.68 | 10.04 | 2180 | 262363 | 169204 | 55858320 |
Product use issue | 754.74 | 10.04 | 2250 | 262293 | 183791 | 55843733 |
Rheumatoid factor positive | 684.72 | 10.04 | 1192 | 263351 | 67868 | 55959656 |
Embolia cutis medicamentosa | 664.33 | 10.04 | 180 | 264363 | 175 | 56027349 |
Hypersensitivity | 617.53 | 10.04 | 2612 | 261931 | 253796 | 55773728 |
Death | 606.97 | 10.04 | 433 | 264110 | 340993 | 55686531 |
Drug intolerance | 565.10 | 10.04 | 2602 | 261941 | 262216 | 55765308 |
Joint swelling | 552.30 | 10.04 | 2756 | 261787 | 287044 | 55740480 |
Treatment failure | 543.02 | 10.04 | 1898 | 262645 | 168494 | 55859030 |
Pain | 485.43 | 10.04 | 4997 | 259546 | 658187 | 55369337 |
Blister | 450.49 | 10.04 | 1327 | 263216 | 107560 | 55919964 |
Muscle injury | 412.20 | 10.04 | 820 | 263723 | 51680 | 55975844 |
Folliculitis | 403.48 | 10.04 | 835 | 263708 | 54144 | 55973380 |
Rheumatic fever | 384.85 | 10.04 | 570 | 263973 | 28257 | 55999267 |
Irritable bowel syndrome | 363.79 | 10.04 | 915 | 263628 | 67543 | 55959981 |
Sleep disorder due to general medical condition, insomnia type | 359.73 | 10.04 | 693 | 263850 | 42645 | 55984879 |
Therapeutic product effect decreased | 359.33 | 10.04 | 1663 | 262880 | 167789 | 55859735 |
Swollen joint count increased | 351.71 | 10.04 | 498 | 264045 | 23686 | 56003838 |
Rash | 344.43 | 10.04 | 3683 | 260860 | 489364 | 55538160 |
Musculoskeletal stiffness | 297.36 | 10.04 | 1485 | 263058 | 154522 | 55873002 |
Diarrhoea | 296.59 | 10.04 | 1775 | 262768 | 636732 | 55390792 |
Hip arthroplasty | 292.07 | 10.04 | 594 | 263949 | 38029 | 55989495 |
Neutropenia | 289.28 | 10.04 | 194 | 264349 | 157973 | 55869551 |
Completed suicide | 280.57 | 10.04 | 139 | 264404 | 133694 | 55893830 |
Febrile neutropenia | 279.66 | 10.04 | 75 | 264468 | 105470 | 55922054 |
Toxicity to various agents | 272.00 | 10.04 | 396 | 264147 | 224168 | 55803356 |
Impaired healing | 258.81 | 10.04 | 947 | 263596 | 85894 | 55941630 |
Pneumonia | 256.31 | 10.04 | 1015 | 263528 | 406083 | 55621441 |
Liver injury | 240.99 | 10.04 | 577 | 263966 | 41271 | 55986253 |
Gastrointestinal disorder | 234.21 | 10.04 | 1100 | 263443 | 111602 | 55915922 |
Knee arthroplasty | 233.41 | 10.04 | 590 | 263953 | 43669 | 55983855 |
Type 2 diabetes mellitus | 229.95 | 10.04 | 608 | 263935 | 46254 | 55981270 |
Psoriatic arthropathy | 228.95 | 10.04 | 817 | 263726 | 73191 | 55954333 |
Deafness transitory | 219.18 | 10.04 | 128 | 264415 | 1814 | 56025710 |
Blood cholesterol increased | 211.64 | 10.04 | 786 | 263757 | 71793 | 55955731 |
Nausea | 208.38 | 10.04 | 2446 | 262097 | 761732 | 55265792 |
Hypotension | 204.89 | 10.04 | 556 | 263987 | 249952 | 55777572 |
Cough | 204.46 | 10.04 | 588 | 263955 | 259373 | 55768151 |
Product dose omission issue | 188.85 | 10.04 | 427 | 264116 | 204326 | 55823198 |
Fall | 171.68 | 10.04 | 982 | 263561 | 356528 | 55670996 |
Thrombocytopenia | 169.98 | 10.04 | 235 | 264308 | 135989 | 55891535 |
Cardiac failure congestive | 165.19 | 10.04 | 104 | 264439 | 87616 | 55939908 |
Constipation | 160 | 10.04 | 455 | 264088 | 201488 | 55826036 |
General physical health deterioration | 156.63 | 10.04 | 1348 | 263195 | 168662 | 55858862 |
Seizure | 152.96 | 10.04 | 219 | 264324 | 124900 | 55902624 |
Dehydration | 136.23 | 10.04 | 344 | 264199 | 158481 | 55869043 |
Electrocardiogram QT prolonged | 135.05 | 10.04 | 44 | 264499 | 54544 | 55972980 |
Ankylosing spondylitis | 133.43 | 10.04 | 197 | 264346 | 9733 | 56017791 |
Urinary tract infection | 132.52 | 10.04 | 630 | 263913 | 239883 | 55787641 |
Ill-defined disorder | 129.36 | 10.04 | 651 | 263892 | 67892 | 55959632 |
Stomatitis | 127.44 | 10.04 | 988 | 263555 | 119822 | 55907702 |
Lower respiratory tract infection | 125.11 | 10.04 | 946 | 263597 | 113848 | 55913676 |
Atrial fibrillation | 124.98 | 10.04 | 199 | 264344 | 108698 | 55918826 |
Hypokalaemia | 123.82 | 10.04 | 157 | 264386 | 94280 | 55933244 |
Pancytopenia | 123.20 | 10.04 | 141 | 264402 | 88574 | 55938950 |
Plasma cell myeloma | 121.91 | 10.04 | 34 | 264509 | 46612 | 55980912 |
Anxiety | 118.48 | 10.04 | 486 | 264057 | 192686 | 55834838 |
Gastric ulcer perforation | 118.08 | 10.04 | 72 | 264471 | 1109 | 56026415 |
Infection | 116.78 | 10.04 | 1446 | 263097 | 198760 | 55828764 |
White blood cell count decreased | 116.68 | 10.04 | 262 | 264281 | 125728 | 55901796 |
Sleep disorder | 114.83 | 10.04 | 624 | 263919 | 67039 | 55960485 |
Disease progression | 111.67 | 10.04 | 202 | 264341 | 104971 | 55922553 |
Ear infection | 111.22 | 10.04 | 362 | 264181 | 30933 | 55996591 |
Asthenia | 110.27 | 10.04 | 1055 | 263488 | 341918 | 55685606 |
Sepsis | 109.29 | 10.04 | 317 | 264226 | 139523 | 55888001 |
Device expulsion | 109.23 | 10.04 | 9 | 264534 | 30440 | 55997084 |
Anaemia | 106.73 | 10.04 | 777 | 263766 | 266734 | 55760790 |
Cerebrovascular accident | 105.99 | 10.04 | 190 | 264353 | 99080 | 55928444 |
Arthralgia | 104.56 | 10.04 | 3090 | 261453 | 498579 | 55528945 |
Platelet count decreased | 103.67 | 10.04 | 215 | 264328 | 106168 | 55921356 |
Gastrointestinal pain | 103.64 | 10.04 | 164 | 264379 | 8613 | 56018911 |
Leukopenia | 99.31 | 10.04 | 112 | 264431 | 70828 | 55956696 |
Pharyngitis | 98.61 | 10.04 | 248 | 264295 | 18290 | 56009234 |
Neuropathy peripheral | 98.54 | 10.04 | 210 | 264333 | 102683 | 55924841 |
Grip strength decreased | 97.74 | 10.04 | 228 | 264315 | 16028 | 56011496 |
Intentional product use issue | 96.10 | 10.04 | 799 | 263744 | 98934 | 55928590 |
Gastric ulcer | 96.04 | 10.04 | 278 | 264265 | 22285 | 56005239 |
Cardiac arrest | 95.97 | 10.04 | 161 | 264382 | 86153 | 55941371 |
Melaena | 95.86 | 10.04 | 322 | 264221 | 27968 | 55999556 |
Balance disorder | 85.75 | 10.04 | 142 | 264401 | 76378 | 55951146 |
Hospitalisation | 85.15 | 10.04 | 138 | 264405 | 74862 | 55952662 |
Neutrophil count decreased | 84.62 | 10.04 | 66 | 264477 | 49756 | 55977768 |
Off label use | 83.85 | 10.04 | 1983 | 262560 | 554197 | 55473327 |
Contusion | 82.47 | 10.04 | 945 | 263598 | 127485 | 55900039 |
Pulmonary arterial hypertension | 82.20 | 10.04 | 13 | 264530 | 26490 | 56001034 |
Live birth | 79.10 | 10.04 | 237 | 264306 | 19368 | 56008156 |
Hypoxia | 78.86 | 10.04 | 82 | 264461 | 53815 | 55973709 |
Dyspnoea | 77.53 | 10.04 | 2157 | 262386 | 590420 | 55437104 |
Cognitive disorder | 77.40 | 10.04 | 70 | 264473 | 49063 | 55978461 |
Oxygen saturation decreased | 76.85 | 10.04 | 160 | 264383 | 78907 | 55948617 |
Shoulder arthroplasty | 76.75 | 10.04 | 91 | 264452 | 3622 | 56023902 |
Pleural effusion | 76.50 | 10.04 | 181 | 264362 | 85299 | 55942225 |
Cardio-respiratory arrest | 75.63 | 10.04 | 89 | 264454 | 55232 | 55972292 |
Injection site pain | 75.35 | 10.04 | 289 | 264254 | 116829 | 55910695 |
Fatigue | 75.00 | 10.04 | 4470 | 260073 | 784082 | 55243442 |
Heart rate increased | 73.99 | 10.04 | 177 | 264366 | 83096 | 55944428 |
Cardiac failure | 73.33 | 10.04 | 174 | 264369 | 81919 | 55945605 |
Malignant neoplasm progression | 71.44 | 10.04 | 149 | 264394 | 73438 | 55954086 |
Depression | 71.36 | 10.04 | 524 | 264019 | 179593 | 55847931 |
Pulmonary embolism | 70.43 | 10.04 | 262 | 264281 | 106862 | 55920662 |
Hypoglycaemia | 69.86 | 10.04 | 96 | 264447 | 55719 | 55971805 |
Fibromyalgia | 68.76 | 10.04 | 498 | 264045 | 59105 | 55968419 |
Bradycardia | 68.68 | 10.04 | 133 | 264410 | 67371 | 55960153 |
Red blood cell sedimentation rate abnormal | 68.44 | 10.04 | 5 | 264538 | 18668 | 56008856 |
Epistaxis | 68.24 | 10.04 | 132 | 264411 | 66891 | 55960633 |
Coma | 67.49 | 10.04 | 110 | 264433 | 59545 | 55967979 |
Tachycardia | 66.99 | 10.04 | 263 | 264280 | 105613 | 55921911 |
Insomnia | 65.51 | 10.04 | 581 | 263962 | 191279 | 55836245 |
Respiratory failure | 65.47 | 10.04 | 228 | 264315 | 94834 | 55932690 |
Wrong technique in product usage process | 65.12 | 10.04 | 108 | 264435 | 58060 | 55969464 |
Osteoarthritis | 64.82 | 10.04 | 619 | 263924 | 79677 | 55947847 |
Mental status changes | 63.28 | 10.04 | 50 | 264493 | 37451 | 55990073 |
COVID-19 | 63.20 | 10.04 | 164 | 264379 | 74894 | 55952630 |
Myocardial infarction | 63.12 | 10.04 | 224 | 264319 | 92646 | 55934878 |
Pulmonary oedema | 61.98 | 10.04 | 90 | 264453 | 51053 | 55976471 |
Multiple sclerosis relapse | 61.64 | 10.04 | 72 | 264471 | 44831 | 55982693 |
Chest discomfort | 61.63 | 10.04 | 247 | 264296 | 98610 | 55928914 |
Blood glucose increased | 61.16 | 10.04 | 167 | 264376 | 74984 | 55952540 |
Neoplasm progression | 60.19 | 10.04 | 38 | 264505 | 31978 | 55995546 |
Tonsillar ulcer | 60.01 | 10.04 | 29 | 264514 | 272 | 56027252 |
Mucosal inflammation | 59.46 | 10.04 | 68 | 264475 | 42742 | 55984782 |
Drug ineffective | 58.92 | 10.04 | 5045 | 259498 | 913944 | 55113580 |
Clostridium difficile infection | 58.86 | 10.04 | 27 | 264516 | 27171 | 56000353 |
Fluid retention | 58.16 | 10.04 | 103 | 264440 | 53975 | 55973549 |
Anaphylactic shock | 58.03 | 10.04 | 229 | 264314 | 21511 | 56006013 |
Duodenal ulcer | 57.61 | 10.04 | 113 | 264430 | 7042 | 56020482 |
Intestinal diaphragm disease | 57.31 | 10.04 | 21 | 264522 | 89 | 56027435 |
Vomiting | 56.31 | 10.04 | 1849 | 262694 | 496379 | 55531145 |
Lethargy | 55.30 | 10.04 | 98 | 264445 | 51343 | 55976181 |
Pneumonia aspiration | 54.95 | 10.04 | 43 | 264500 | 32368 | 55995156 |
Asthma | 54.90 | 10.04 | 308 | 264235 | 112462 | 55915062 |
No adverse event | 54.74 | 10.04 | 54 | 264489 | 36320 | 55991204 |
Injury | 53.68 | 10.04 | 472 | 264071 | 59379 | 55968145 |
Adverse event | 53.50 | 10.04 | 444 | 264099 | 54932 | 55972592 |
Hyperglycaemia | 51.88 | 10.04 | 62 | 264481 | 38219 | 55989305 |
Bronchitis | 51.87 | 10.04 | 312 | 264231 | 111999 | 55915525 |
Functional gastrointestinal disorder | 51.83 | 10.04 | 76 | 264467 | 3731 | 56023793 |
Posterior reversible encephalopathy syndrome | 51.41 | 10.04 | 7 | 264536 | 15953 | 56011571 |
Injection site erythema | 51.17 | 10.04 | 189 | 264354 | 77259 | 55950265 |
Blood pressure increased | 50.70 | 10.04 | 437 | 264106 | 144739 | 55882785 |
Abdominal pain | 50.08 | 10.04 | 885 | 263658 | 257920 | 55769604 |
Chills | 50.07 | 10.04 | 280 | 264263 | 102324 | 55925200 |
Sedation | 49.90 | 10.04 | 54 | 264489 | 34800 | 55992724 |
Device dislocation | 49.61 | 10.04 | 22 | 264521 | 22584 | 56004940 |
Prescribed overdose | 49.49 | 10.04 | 222 | 264321 | 22074 | 56005450 |
Angioedema | 49.34 | 10.04 | 349 | 264194 | 41104 | 55986420 |
Pancreatitis | 49.26 | 10.04 | 85 | 264458 | 44995 | 55982529 |
Premature delivery | 48.33 | 10.04 | 34 | 264509 | 27026 | 56000498 |
Small intestine ulcer | 48.27 | 10.04 | 26 | 264517 | 312 | 56027212 |
Chronic obstructive pulmonary disease | 47.91 | 10.04 | 126 | 264417 | 57289 | 55970235 |
Respiratory distress | 47.67 | 10.04 | 47 | 264496 | 31620 | 55995904 |
Influenza | 47.56 | 10.04 | 258 | 264285 | 95003 | 55932521 |
Retinitis | 47.24 | 10.04 | 77 | 264466 | 4147 | 56023377 |
Syncope | 47.16 | 10.04 | 306 | 264237 | 107893 | 55919631 |
Acute myeloid leukaemia | 46.98 | 10.04 | 11 | 264532 | 16961 | 56010563 |
Blood potassium decreased | 46.91 | 10.04 | 68 | 264475 | 38604 | 55988920 |
Type I hypersensitivity | 46.77 | 10.04 | 58 | 264485 | 2420 | 56025104 |
Unevaluable event | 46.75 | 10.04 | 96 | 264447 | 47591 | 55979933 |
Hyponatraemia | 46.50 | 10.04 | 285 | 264258 | 101854 | 55925670 |
Renal failure neonatal | 46.31 | 10.04 | 21 | 264522 | 168 | 56027356 |
Large intestinal stenosis | 46.31 | 10.04 | 49 | 264494 | 1717 | 56025807 |
Deep vein thrombosis | 46.30 | 10.04 | 195 | 264348 | 76782 | 55950742 |
Diabetes mellitus | 46.12 | 10.04 | 113 | 264430 | 52622 | 55974902 |
Dislocation of vertebra | 45.40 | 10.04 | 87 | 264456 | 5328 | 56022196 |
Hypomagnesaemia | 45.25 | 10.04 | 31 | 264512 | 24984 | 56002540 |
Ductus arteriosus stenosis foetal | 44.65 | 10.04 | 20 | 264523 | 155 | 56027369 |
Complication associated with device | 44.41 | 10.04 | 9 | 264534 | 15341 | 56012183 |
Incorrect dose administered | 44.09 | 10.04 | 115 | 264428 | 52432 | 55975092 |
Drug tolerance decreased | 43.98 | 10.04 | 151 | 264392 | 13260 | 56014264 |
Cytomegalovirus infection | 43.59 | 10.04 | 18 | 264525 | 19278 | 56008246 |
Dry skin | 42.74 | 10.04 | 99 | 264444 | 47010 | 55980514 |
Septic shock | 42.49 | 10.04 | 145 | 264398 | 60690 | 55966834 |
Large intestinal ulcer | 42.20 | 10.04 | 63 | 264480 | 3143 | 56024381 |
Fat necrosis | 41.93 | 10.04 | 30 | 264513 | 612 | 56026912 |
Flushing | 41.90 | 10.04 | 178 | 264365 | 69922 | 55957602 |
Injection site bruising | 41.75 | 10.04 | 73 | 264470 | 38448 | 55989076 |
Drug abuse | 41.45 | 10.04 | 170 | 264373 | 67440 | 55960084 |
Full blood count abnormal | 41.32 | 10.04 | 38 | 264505 | 26424 | 56001100 |
Ileal ulcer | 41.30 | 10.04 | 26 | 264517 | 425 | 56027099 |
Joint range of motion decreased | 41.06 | 10.04 | 231 | 264312 | 25134 | 56002390 |
Agitation | 40.90 | 10.04 | 131 | 264412 | 55905 | 55971619 |
Condition aggravated | 40.68 | 10.04 | 1996 | 262547 | 342902 | 55684622 |
Joint dislocation | 40.38 | 10.04 | 164 | 264379 | 15609 | 56011915 |
Dysphagia | 40.32 | 10.04 | 223 | 264320 | 81724 | 55945800 |
Renal failure | 39.75 | 10.04 | 330 | 264213 | 110170 | 55917354 |
Orthostatic hypotension | 39.66 | 10.04 | 59 | 264484 | 33140 | 55994384 |
Neuroleptic malignant syndrome | 39.54 | 10.04 | 4 | 264539 | 11474 | 56016050 |
Liver function test abnormal | 39.05 | 10.04 | 99 | 264444 | 45572 | 55981952 |
Ascites | 39.03 | 10.04 | 73 | 264470 | 37471 | 55990053 |
Hypervolaemia | 38.99 | 10.04 | 40 | 264503 | 26418 | 56001106 |
Metastases to liver | 38.72 | 10.04 | 27 | 264516 | 21559 | 56005965 |
Feeling abnormal | 38.67 | 10.04 | 421 | 264122 | 133181 | 55894343 |
Neurotoxicity | 38.59 | 10.04 | 13 | 264530 | 15782 | 56011742 |
Cellulitis | 38.51 | 10.04 | 201 | 264342 | 74748 | 55952776 |
Therapeutic product effect incomplete | 38.43 | 10.04 | 316 | 264227 | 105715 | 55921809 |
Myelosuppression | 38.28 | 10.04 | 17 | 264526 | 17438 | 56010086 |
Generalised tonic-clonic seizure | 38.05 | 10.04 | 44 | 264499 | 27522 | 56000002 |
Gastrointestinal erosion | 37.95 | 10.04 | 28 | 264515 | 600 | 56026924 |
Hypercalcaemia | 37.92 | 10.04 | 38 | 264505 | 25373 | 56002151 |
Ductus arteriosus premature closure | 37.90 | 10.04 | 22 | 264521 | 308 | 56027216 |
Sedation complication | 37.88 | 10.04 | 5 | 264538 | 11667 | 56015857 |
Status epilepticus | 37.80 | 10.04 | 12 | 264531 | 15129 | 56012395 |
Dyspnoea exertional | 37.76 | 10.04 | 131 | 264412 | 54558 | 55972966 |
Nasopharyngitis | 37.74 | 10.04 | 1330 | 263213 | 219629 | 55807895 |
Palpitations | 37.53 | 10.04 | 294 | 264249 | 99378 | 55928146 |
Chest pain | 37.33 | 10.04 | 647 | 263896 | 189150 | 55838374 |
Unresponsive to stimuli | 37.30 | 10.04 | 57 | 264486 | 31668 | 55995856 |
Somnolence | 37.18 | 10.04 | 542 | 264001 | 162871 | 55864653 |
Urosepsis | 37.10 | 10.04 | 16 | 264527 | 16700 | 56010824 |
Bone marrow failure | 37.08 | 10.04 | 47 | 264496 | 28239 | 55999285 |
Palmar-plantar erythrodysaesthesia syndrome | 36.93 | 10.04 | 27 | 264516 | 21038 | 56006486 |
Facet joint syndrome | 36.92 | 10.04 | 91 | 264452 | 6626 | 56020898 |
Laboratory test abnormal | 36.77 | 10.04 | 37 | 264506 | 24658 | 56002866 |
Torsade de pointes | 36.61 | 10.04 | 7 | 264536 | 12433 | 56015091 |
Injection site necrosis | 36.45 | 10.04 | 37 | 264506 | 1234 | 56026290 |
Product quality issue | 36.38 | 10.04 | 58 | 264485 | 31678 | 55995846 |
Peripheral swelling | 36.24 | 10.04 | 1397 | 263146 | 233329 | 55794195 |
Duodenal ulcer haemorrhage | 36.01 | 10.04 | 49 | 264494 | 2243 | 56025281 |
Device issue | 35.78 | 10.04 | 28 | 264515 | 21078 | 56006446 |
Adjustment disorder with depressed mood | 35.65 | 10.04 | 76 | 264467 | 5027 | 56022497 |
Upper respiratory tract infection | 35.62 | 10.04 | 193 | 264350 | 71095 | 55956429 |
Headache | 35.54 | 10.04 | 2209 | 262334 | 556835 | 55470689 |
Transplant rejection | 35.45 | 10.04 | 3 | 264540 | 9931 | 56017593 |
Hypocalcaemia | 35.45 | 10.04 | 50 | 264493 | 28710 | 55998814 |
Neoplasm malignant | 35.42 | 10.04 | 45 | 264498 | 27010 | 56000514 |
Vision blurred | 35.42 | 10.04 | 236 | 264307 | 82707 | 55944817 |
Ejection fraction decreased | 35.34 | 10.04 | 25 | 264518 | 19816 | 56007708 |
Endoscopy abnormal | 35.33 | 10.04 | 9 | 264534 | 5 | 56027519 |
Sopor | 35.16 | 10.04 | 28 | 264515 | 20894 | 56006630 |
Foetal methotrexate syndrome | 35.12 | 10.04 | 14 | 264529 | 78 | 56027446 |
Hallucination | 34.42 | 10.04 | 117 | 264426 | 49032 | 55978492 |
Sacroiliitis | 34.40 | 10.04 | 53 | 264490 | 2719 | 56024805 |
Nasal congestion | 34.39 | 10.04 | 142 | 264401 | 56228 | 55971296 |
Productive cough | 34.09 | 10.04 | 142 | 264401 | 56090 | 55971434 |
Tremor | 34.08 | 10.04 | 384 | 264159 | 120705 | 55906819 |
Anti-cyclic citrullinated peptide antibody | 33.94 | 10.04 | 62 | 264481 | 3661 | 56023863 |
Drug resistance | 33.89 | 10.04 | 28 | 264515 | 20514 | 56007010 |
Anaphylactic reaction | 33.84 | 10.04 | 425 | 264118 | 58570 | 55968954 |
Oligohydramnios | 33.79 | 10.04 | 82 | 264461 | 5912 | 56021612 |
Jejunal ulcer | 33.72 | 10.04 | 14 | 264529 | 88 | 56027436 |
Maternal exposure timing unspecified | 33.63 | 10.04 | 77 | 264466 | 5346 | 56022178 |
Foot operation | 33.50 | 10.04 | 84 | 264459 | 6183 | 56021341 |
Transfusion | 33.25 | 10.04 | 11 | 264532 | 13509 | 56014015 |
Lower respiratory tract infection viral | 33.17 | 10.04 | 29 | 264514 | 798 | 56026726 |
Intestinal obstruction | 33.13 | 10.04 | 50 | 264493 | 27921 | 55999603 |
Feeding disorder | 33.10 | 10.04 | 127 | 264416 | 11773 | 56015751 |
Abnormal behaviour | 32.99 | 10.04 | 28 | 264515 | 20244 | 56007280 |
Cardiac disorder | 32.99 | 10.04 | 108 | 264435 | 45779 | 55981745 |
Haemoglobin decreased | 32.97 | 10.04 | 438 | 264105 | 133699 | 55893825 |
Weight decreased | 32.93 | 10.04 | 870 | 263673 | 239844 | 55787680 |
Deep vein thrombosis postoperative | 32.75 | 10.04 | 64 | 264479 | 3977 | 56023547 |
Depressed level of consciousness | 32.69 | 10.04 | 145 | 264398 | 56288 | 55971236 |
Extrapyramidal disorder | 32.29 | 10.04 | 9 | 264534 | 12347 | 56015177 |
Confusional state | 32.16 | 10.04 | 1239 | 263304 | 206916 | 55820608 |
Abortion spontaneous | 32.13 | 10.04 | 102 | 264441 | 43651 | 55983873 |
Psychotic disorder | 32.09 | 10.04 | 38 | 264505 | 23520 | 56004004 |
Diabetic ketoacidosis | 32.04 | 10.04 | 25 | 264518 | 18846 | 56008678 |
Malaise | 31.98 | 10.04 | 1408 | 263135 | 366452 | 55661072 |
Stress | 31.97 | 10.04 | 155 | 264388 | 58755 | 55968769 |
Blood calcium decreased | 31.67 | 10.04 | 39 | 264504 | 23730 | 56003794 |
Lip dry | 31.36 | 10.04 | 109 | 264434 | 9631 | 56017893 |
Atelectasis | 31.02 | 10.04 | 27 | 264516 | 19281 | 56008243 |
Progressive multifocal leukoencephalopathy | 30.93 | 10.04 | 9 | 264534 | 12004 | 56015520 |
Schizophrenia | 30.70 | 10.04 | 6 | 264537 | 10493 | 56017031 |
Porphyria acute | 30.68 | 10.04 | 29 | 264514 | 885 | 56026639 |
Encephalopathy | 30.65 | 10.04 | 76 | 264467 | 35249 | 55992275 |
Abnormal loss of weight | 30.26 | 10.04 | 73 | 264470 | 5243 | 56022281 |
Suicidal ideation | 30.15 | 10.04 | 154 | 264389 | 57588 | 55969936 |
Gastritis erosive | 30.07 | 10.04 | 75 | 264468 | 5502 | 56022022 |
Overdose | 30.02 | 10.04 | 335 | 264208 | 105495 | 55922029 |
Macular degeneration | 29.70 | 10.04 | 27 | 264516 | 18881 | 56008643 |
Throat irritation | 29.39 | 10.04 | 69 | 264474 | 32614 | 55994910 |
Aspirin-exacerbated respiratory disease | 29.23 | 10.04 | 28 | 264515 | 869 | 56026655 |
Pericardial effusion | 29.00 | 10.04 | 52 | 264491 | 27123 | 56000401 |
Right ventricular failure | 28.70 | 10.04 | 21 | 264522 | 16358 | 56011166 |
Periorbital oedema | 28.69 | 10.04 | 71 | 264472 | 5183 | 56022341 |
Injection site pruritus | 28.57 | 10.04 | 101 | 264442 | 41830 | 55985694 |
Aggression | 28.40 | 10.04 | 37 | 264506 | 21969 | 56005555 |
Erythema | 28.32 | 10.04 | 539 | 264004 | 155400 | 55872124 |
Hepatic failure | 28.31 | 10.04 | 73 | 264470 | 33413 | 55994111 |
Cytokine release syndrome | 28.27 | 10.04 | 8 | 264535 | 10867 | 56016657 |
Respiratory disorder | 27.96 | 10.04 | 75 | 264468 | 33882 | 55993642 |
Pulmonary hypertension | 27.67 | 10.04 | 82 | 264461 | 35862 | 55991662 |
Bacteraemia | 27.44 | 10.04 | 20 | 264523 | 15611 | 56011913 |
Accidental exposure to product | 27.36 | 10.04 | 46 | 264497 | 24601 | 56002923 |
X-ray abnormal | 27.32 | 10.04 | 62 | 264481 | 4279 | 56023245 |
Injection site reaction | 27.24 | 10.04 | 143 | 264400 | 53104 | 55974420 |
Depressed mood | 27.24 | 10.04 | 84 | 264459 | 36275 | 55991249 |
Neutropenic sepsis | 27.22 | 10.04 | 19 | 264524 | 15166 | 56012358 |
Device related infection | 27.01 | 10.04 | 38 | 264505 | 21842 | 56005682 |
Blood pressure fluctuation | 26.98 | 10.04 | 98 | 264445 | 40262 | 55987262 |
Thrombosis | 26.95 | 10.04 | 166 | 264377 | 59261 | 55968263 |
Breast cancer metastatic | 26.89 | 10.04 | 20 | 264523 | 15449 | 56012075 |
Blood glucose decreased | 26.85 | 10.04 | 30 | 264513 | 19057 | 56008467 |
Lymphocyte count decreased | 26.75 | 10.04 | 57 | 264486 | 27882 | 55999642 |
Therapy cessation | 26.62 | 10.04 | 55 | 264488 | 27209 | 56000315 |
Sinus disorder | 26.61 | 10.04 | 35 | 264508 | 20699 | 56006825 |
Liver function test increased | 26.43 | 10.04 | 58 | 264485 | 28075 | 55999449 |
Multiple sclerosis | 26.38 | 10.04 | 57 | 264486 | 27745 | 55999779 |
Spinal stenosis | 26.35 | 10.04 | 133 | 264410 | 13881 | 56013643 |
Influenza like illness | 26.30 | 10.04 | 173 | 264370 | 60815 | 55966709 |
Haematotoxicity | 26.25 | 10.04 | 4 | 264539 | 8379 | 56019145 |
Myocarditis | 26.03 | 10.04 | 5 | 264538 | 8853 | 56018671 |
Paranoia | 25.97 | 10.04 | 9 | 264534 | 10735 | 56016789 |
Ventricular tachycardia | 25.53 | 10.04 | 25 | 264518 | 16876 | 56010648 |
Full blood count decreased | 25.53 | 10.04 | 44 | 264499 | 23305 | 56004219 |
Treatment noncompliance | 25.42 | 10.04 | 74 | 264469 | 32549 | 55994975 |
Infective pulmonary exacerbation of cystic fibrosis | 25.30 | 10.04 | 4 | 264539 | 8153 | 56019371 |
Akathisia | 25.18 | 10.04 | 5 | 264538 | 8647 | 56018877 |
Dizziness | 25.13 | 10.04 | 1479 | 263064 | 374661 | 55652863 |
Bone disorder | 25.07 | 10.04 | 33 | 264510 | 19510 | 56008014 |
Neonatal intestinal perforation | 24.99 | 10.04 | 8 | 264535 | 20 | 56027504 |
Gestational diabetes | 24.90 | 10.04 | 4 | 264539 | 8060 | 56019464 |
Psoriasis | 24.89 | 10.04 | 297 | 264246 | 92395 | 55935129 |
Oral pain | 24.87 | 10.04 | 54 | 264489 | 26239 | 56001285 |
Hepatotoxicity | 24.76 | 10.04 | 70 | 264473 | 31083 | 55996441 |
Ataxia | 24.55 | 10.04 | 19 | 264524 | 14384 | 56013140 |
Breast cancer | 24.50 | 10.04 | 132 | 264411 | 48701 | 55978823 |
Rhinorrhoea | 24.49 | 10.04 | 162 | 264381 | 56875 | 55970649 |
Heavy menstrual bleeding | 24.46 | 10.04 | 24 | 264519 | 16185 | 56011339 |
Second primary malignancy | 24.44 | 10.04 | 3 | 264540 | 7399 | 56020125 |
Osteonecrosis of jaw | 24.33 | 10.04 | 78 | 264465 | 33280 | 55994244 |
Thrombotic microangiopathy | 24.33 | 10.04 | 7 | 264536 | 9404 | 56018120 |
Blood test abnormal | 24.27 | 10.04 | 15 | 264528 | 12769 | 56014755 |
Mobility decreased | 24.21 | 10.04 | 623 | 263920 | 98368 | 55929156 |
Application site rash | 24.21 | 10.04 | 42 | 264501 | 2381 | 56025143 |
Lupus vulgaris | 24.11 | 10.04 | 37 | 264506 | 1892 | 56025632 |
Mania | 24.06 | 10.04 | 12 | 264531 | 11508 | 56016016 |
Frequent bowel movements | 24.01 | 10.04 | 25 | 264518 | 16399 | 56011125 |
Laryngitis | 23.97 | 10.04 | 129 | 264414 | 13801 | 56013723 |
Haemorrhage | 23.80 | 10.04 | 161 | 264382 | 56236 | 55971288 |
Lung neoplasm malignant | 23.76 | 10.04 | 28 | 264515 | 17368 | 56010156 |
Adverse drug reaction | 23.66 | 10.04 | 434 | 264109 | 64698 | 55962826 |
Respiratory tract congestion | 23.63 | 10.04 | 23 | 264520 | 15568 | 56011956 |
Drug interaction | 23.46 | 10.04 | 779 | 263764 | 208976 | 55818548 |
Injection site swelling | 23.45 | 10.04 | 115 | 264428 | 43463 | 55984061 |
Obstructive airways disorder | 23.40 | 10.04 | 28 | 264515 | 17254 | 56010270 |
Back pain | 23.30 | 10.04 | 895 | 263648 | 236275 | 55791249 |
Rotator cuff repair | 23.27 | 10.04 | 36 | 264507 | 1854 | 56025670 |
Rhabdomyolysis | 23.22 | 10.04 | 105 | 264438 | 40553 | 55986971 |
Feeling cold | 23.10 | 10.04 | 40 | 264503 | 21147 | 56006377 |
Seronegative arthritis | 22.99 | 10.04 | 44 | 264499 | 2692 | 56024832 |
Injection site mass | 22.96 | 10.04 | 27 | 264516 | 16766 | 56010758 |
Haematocrit decreased | 22.95 | 10.04 | 92 | 264451 | 36737 | 55990787 |
Cerebral haemorrhage | 22.94 | 10.04 | 64 | 264479 | 28542 | 55998982 |
Abdominal rebound tenderness | 22.93 | 10.04 | 7 | 264536 | 14 | 56027510 |
Intestinal ulcer | 22.81 | 10.04 | 28 | 264515 | 1156 | 56026368 |
Breast cancer female | 22.70 | 10.04 | 15 | 264528 | 12323 | 56015201 |
Fear | 22.58 | 10.04 | 22 | 264521 | 14886 | 56012638 |
Corneal epithelium defect | 22.55 | 10.04 | 16 | 264527 | 322 | 56027202 |
Panniculitis | 22.52 | 10.04 | 9 | 264534 | 9833 | 56017691 |
Red blood cell count decreased | 22.49 | 10.04 | 92 | 264451 | 36525 | 55990999 |
Haemoptysis | 22.37 | 10.04 | 58 | 264485 | 26502 | 56001022 |
Injection site haemorrhage | 22.35 | 10.04 | 44 | 264499 | 22157 | 56005367 |
Synostosis | 22.31 | 10.04 | 9 | 264534 | 52 | 56027472 |
Cytopenia | 22.19 | 10.04 | 9 | 264534 | 9746 | 56017778 |
Emotional distress | 22.12 | 10.04 | 69 | 264474 | 29694 | 55997830 |
Small intestinal obstruction | 22.01 | 10.04 | 28 | 264515 | 16797 | 56010727 |
Metastases to central nervous system | 22.00 | 10.04 | 15 | 264528 | 12121 | 56015403 |
Dysgeusia | 22.00 | 10.04 | 108 | 264435 | 40807 | 55986717 |
Diabetes mellitus inadequate control | 21.92 | 10.04 | 20 | 264523 | 13960 | 56013564 |
Congenital pulmonary hypertension | 21.89 | 10.04 | 9 | 264534 | 55 | 56027469 |
Soft tissue injury | 21.88 | 10.04 | 32 | 264511 | 1567 | 56025957 |
Lymphopenia | 21.85 | 10.04 | 28 | 264515 | 16746 | 56010778 |
Inappropriate schedule of product administration | 21.70 | 10.04 | 269 | 264274 | 83118 | 55944406 |
Neonatal respiratory acidosis | 21.65 | 10.04 | 12 | 264531 | 153 | 56027371 |
Muscle spasms | 21.63 | 10.04 | 486 | 264057 | 136885 | 55890639 |
Paraesthesia | 21.63 | 10.04 | 458 | 264085 | 130056 | 55897468 |
Oropharyngeal pain | 21.54 | 10.04 | 271 | 264272 | 83517 | 55944007 |
Lacrimation increased | 21.54 | 10.04 | 33 | 264510 | 18315 | 56009209 |
Subdural haematoma | 21.54 | 10.04 | 19 | 264524 | 13480 | 56014044 |
Fungal infection | 21.47 | 10.04 | 81 | 264462 | 32912 | 55994612 |
Synovial cyst | 21.40 | 10.04 | 93 | 264450 | 9121 | 56018403 |
Haematemesis | 21.39 | 10.04 | 218 | 264325 | 28540 | 55998984 |
Epilepsy | 21.33 | 10.04 | 55 | 264488 | 25176 | 56002348 |
Central nervous system lesion | 21.29 | 10.04 | 10 | 264533 | 9928 | 56017596 |
Orbital oedema | 21.22 | 10.04 | 13 | 264530 | 202 | 56027322 |
Hepatitis | 21.17 | 10.04 | 90 | 264453 | 35351 | 55992173 |
Rheumatoid lung | 21.06 | 10.04 | 46 | 264497 | 3094 | 56024430 |
Lymphatic fistula | 20.95 | 10.04 | 22 | 264521 | 764 | 56026760 |
Psychomotor hyperactivity | 20.86 | 10.04 | 10 | 264533 | 9810 | 56017714 |
Mood swings | 20.75 | 10.04 | 29 | 264514 | 16718 | 56010806 |
Hyperhidrosis | 20.72 | 10.04 | 314 | 264229 | 93774 | 55933750 |
Ovulation disorder | 20.71 | 10.04 | 7 | 264536 | 22 | 56027502 |
Femoral hernia incarcerated | 20.61 | 10.04 | 22 | 264521 | 779 | 56026745 |
Arrhythmia | 20.40 | 10.04 | 90 | 264453 | 34993 | 55992531 |
Multiple allergies | 20.37 | 10.04 | 12 | 264531 | 10484 | 56017040 |
Haemorrhage intracranial | 20.29 | 10.04 | 18 | 264525 | 12737 | 56014787 |
Complication of device insertion | 20.26 | 10.04 | 3 | 264540 | 6421 | 56021103 |
Tubulointerstitial nephritis | 20.23 | 10.04 | 141 | 264402 | 16524 | 56011000 |
Acute respiratory failure | 20.23 | 10.04 | 76 | 264467 | 30918 | 55996606 |
Disease recurrence | 20.18 | 10.04 | 52 | 264491 | 23808 | 56003716 |
Loss of consciousness | 20.14 | 10.04 | 377 | 264166 | 108972 | 55918552 |
Aspiration | 20.13 | 10.04 | 10 | 264533 | 9611 | 56017913 |
Clostridium difficile colitis | 19.86 | 10.04 | 36 | 264507 | 18702 | 56008822 |
Sinusitis | 19.73 | 10.04 | 1126 | 263417 | 196455 | 55831069 |
Herpes zoster | 19.67 | 10.04 | 245 | 264298 | 75644 | 55951880 |
Large intestine perforation | 19.59 | 10.04 | 81 | 264462 | 7770 | 56019754 |
Exposure during pregnancy | 19.51 | 10.04 | 805 | 263738 | 135537 | 55891987 |
Product storage error | 19.44 | 10.04 | 20 | 264523 | 13193 | 56014331 |
Blood calcium increased | 19.42 | 10.04 | 7 | 264536 | 8147 | 56019377 |
Respiratory arrest | 19.40 | 10.04 | 76 | 264467 | 30549 | 55996975 |
Procedural pain | 19.35 | 10.04 | 29 | 264514 | 16242 | 56011282 |
Cardiomyopathy | 19.32 | 10.04 | 29 | 264514 | 16229 | 56011295 |
Injection site hyperaesthesia | 19.31 | 10.04 | 8 | 264535 | 50 | 56027474 |
Femur fracture | 19.29 | 10.04 | 107 | 264436 | 39188 | 55988336 |
Creatinine renal clearance decreased | 19.28 | 10.04 | 24 | 264519 | 14535 | 56012989 |
Urine abnormality | 19.23 | 10.04 | 4 | 264539 | 6695 | 56020829 |
Prescribed underdose | 19.21 | 10.04 | 164 | 264379 | 20453 | 56007071 |
Peripheral venous disease | 19.19 | 10.04 | 96 | 264447 | 9983 | 56017541 |
Keratopathy | 19.16 | 10.04 | 18 | 264525 | 545 | 56026979 |
Drug dependence | 19.14 | 10.04 | 49 | 264494 | 22484 | 56005040 |
Ischaemic stroke | 19.10 | 10.04 | 31 | 264512 | 16811 | 56010713 |
Immunodeficiency | 19.02 | 10.04 | 29 | 264514 | 16128 | 56011396 |
Aphasia | 18.94 | 10.04 | 76 | 264467 | 30339 | 55997185 |
Bladder disorder | 18.92 | 10.04 | 7 | 264536 | 8017 | 56019507 |
Abdominal distension | 18.87 | 10.04 | 254 | 264289 | 77372 | 55950152 |
Pancreatic steatosis | 18.82 | 10.04 | 23 | 264520 | 945 | 56026579 |
Arteriovenous fistula occlusion | 18.74 | 10.04 | 15 | 264528 | 364 | 56027160 |
Candida infection | 18.73 | 10.04 | 60 | 264483 | 25607 | 56001917 |
Failure to thrive | 18.70 | 10.04 | 4 | 264539 | 6566 | 56020958 |
Nephrolithiasis | 18.69 | 10.04 | 101 | 264442 | 37234 | 55990290 |
Renal impairment | 18.59 | 10.04 | 267 | 264276 | 80446 | 55947078 |
Serotonin syndrome | 18.59 | 10.04 | 63 | 264480 | 26427 | 56001097 |
Gastric ulcer haemorrhage | 18.53 | 10.04 | 56 | 264487 | 4597 | 56022927 |
Muscle tone disorder | 18.49 | 10.04 | 10 | 264533 | 121 | 56027403 |
Transaminases increased | 18.48 | 10.04 | 71 | 264472 | 28699 | 55998825 |
Skin ulcer | 18.48 | 10.04 | 106 | 264437 | 38502 | 55989022 |
Bedridden | 18.40 | 10.04 | 13 | 264530 | 10312 | 56017212 |
Femur-fibula-ulna complex | 18.38 | 10.04 | 5 | 264538 | 5 | 56027519 |
Urinoma | 18.34 | 10.04 | 7 | 264536 | 34 | 56027490 |
Sleep disorder due to a general medical condition | 18.20 | 10.04 | 10 | 264533 | 9080 | 56018444 |
Bronchopulmonary aspergillosis | 18.20 | 10.04 | 8 | 264535 | 8256 | 56019268 |
Cyanosis neonatal | 18.13 | 10.04 | 13 | 264530 | 266 | 56027258 |
Lip ulceration | 18.11 | 10.04 | 32 | 264511 | 1841 | 56025683 |
Deafness | 17.98 | 10.04 | 136 | 264407 | 16358 | 56011166 |
Pyrexia | 17.83 | 10.04 | 1710 | 262833 | 417063 | 55610461 |
Amenorrhoea | 17.83 | 10.04 | 10 | 264533 | 8976 | 56018548 |
Metabolic acidosis | 17.82 | 10.04 | 114 | 264429 | 40340 | 55987184 |
Nodule | 17.81 | 10.04 | 38 | 264505 | 18581 | 56008943 |
Blue toe syndrome | 17.81 | 10.04 | 15 | 264528 | 392 | 56027132 |
Drug withdrawal syndrome | 17.80 | 10.04 | 62 | 264481 | 25795 | 56001729 |
Gallbladder adenocarcinoma | 17.79 | 10.04 | 9 | 264534 | 94 | 56027430 |
Metastases to bone | 17.69 | 10.04 | 41 | 264502 | 19467 | 56008057 |
Taste disorder | 17.62 | 10.04 | 12 | 264531 | 9703 | 56017821 |
Libido increased | 17.58 | 10.04 | 26 | 264517 | 1286 | 56026238 |
Tenderness | 17.57 | 10.04 | 158 | 264385 | 19997 | 56007527 |
Heart rate irregular | 17.54 | 10.04 | 45 | 264498 | 20634 | 56006890 |
Blood creatinine increased | 17.52 | 10.04 | 268 | 264275 | 79923 | 55947601 |
Hot flush | 17.50 | 10.04 | 138 | 264405 | 46588 | 55980936 |
Urine porphobilinogen increased | 17.46 | 10.04 | 4 | 264539 | 0 | 56027524 |
Multiple organ dysfunction syndrome | 17.46 | 10.04 | 161 | 264382 | 52609 | 55974915 |
Tongue disorder | 17.41 | 10.04 | 13 | 264530 | 10023 | 56017501 |
Oral candidiasis | 17.37 | 10.04 | 39 | 264504 | 18724 | 56008800 |
Dyskinesia | 17.33 | 10.04 | 74 | 264469 | 29034 | 55998490 |
Breast cancer stage I | 17.32 | 10.04 | 4 | 264539 | 6226 | 56021298 |
Upper limb fracture | 17.27 | 10.04 | 34 | 264509 | 17121 | 56010403 |
Hypochromic anaemia | 17.25 | 10.04 | 31 | 264512 | 1807 | 56025717 |
Coagulopathy | 17.24 | 10.04 | 39 | 264504 | 18677 | 56008847 |
Burning sensation | 17.24 | 10.04 | 146 | 264397 | 48550 | 55978974 |
Crying | 17.17 | 10.04 | 48 | 264495 | 21392 | 56006132 |
Punctate keratitis | 17.17 | 10.04 | 17 | 264526 | 550 | 56026974 |
Adactyly | 17.13 | 10.04 | 7 | 264536 | 42 | 56027482 |
Cardiac murmur | 17.07 | 10.04 | 17 | 264526 | 11384 | 56016140 |
Gallbladder disorder | 16.90 | 10.04 | 35 | 264508 | 17299 | 56010225 |
Acute respiratory distress syndrome | 16.89 | 10.04 | 50 | 264493 | 21876 | 56005648 |
Lymphocyte stimulation test positive | 16.88 | 10.04 | 16 | 264527 | 490 | 56027034 |
Aspergillus infection | 16.80 | 10.04 | 7 | 264536 | 7458 | 56020066 |
Adrenal insufficiency | 16.78 | 10.04 | 30 | 264513 | 15667 | 56011857 |
Device occlusion | 16.77 | 10.04 | 5 | 264538 | 6564 | 56020960 |
Soft tissue infection | 16.75 | 10.04 | 32 | 264511 | 1955 | 56025569 |
Complications of intestinal transplant | 16.72 | 10.04 | 5 | 264538 | 9 | 56027515 |
Upper-airway cough syndrome | 16.67 | 10.04 | 12 | 264531 | 9426 | 56018098 |
Autoimmune disorder | 16.58 | 10.04 | 85 | 264458 | 8924 | 56018600 |
Urinary incontinence | 16.54 | 10.04 | 77 | 264466 | 29508 | 55998016 |
Uterine perforation | 16.52 | 10.04 | 5 | 264538 | 6500 | 56021024 |
Intentional overdose | 16.52 | 10.04 | 223 | 264320 | 67894 | 55959630 |
Spinal pain | 16.52 | 10.04 | 104 | 264439 | 11780 | 56015744 |
Cushingoid | 16.50 | 10.04 | 7 | 264536 | 7377 | 56020147 |
Dementia | 16.43 | 10.04 | 35 | 264508 | 17123 | 56010401 |
Thyroid disorder | 16.43 | 10.04 | 25 | 264518 | 13913 | 56013611 |
Creutzfeldt-Jakob disease | 16.40 | 10.04 | 10 | 264533 | 154 | 56027370 |
Therapy change | 16.34 | 10.04 | 3 | 264540 | 5485 | 56022039 |
Electrolyte imbalance | 16.27 | 10.04 | 38 | 264505 | 17995 | 56009529 |
Pulmonary mass | 16.27 | 10.04 | 46 | 264497 | 20424 | 56007100 |
Peritonitis | 16.23 | 10.04 | 131 | 264412 | 16071 | 56011453 |
Visual impairment | 16.21 | 10.04 | 248 | 264295 | 73954 | 55953570 |
Colitis erosive | 16.20 | 10.04 | 8 | 264535 | 79 | 56027445 |
Genital haemorrhage | 16.16 | 10.04 | 6 | 264537 | 6856 | 56020668 |
Kidney infection | 16.16 | 10.04 | 47 | 264496 | 20678 | 56006846 |
Caesarean section | 16.10 | 10.04 | 32 | 264511 | 16059 | 56011465 |
Vasoconstriction | 16.07 | 10.04 | 16 | 264527 | 521 | 56027003 |
Pre-eclampsia | 16.05 | 10.04 | 10 | 264533 | 8476 | 56019048 |
Tachypnoea | 16.04 | 10.04 | 30 | 264513 | 15400 | 56012124 |
Myalgia | 16.03 | 10.04 | 485 | 264058 | 131540 | 55895984 |
Adverse reaction | 16.02 | 10.04 | 87 | 264456 | 9340 | 56018184 |
Infusion site pain | 15.92 | 10.04 | 25 | 264518 | 13737 | 56013787 |
Vaccination site reaction | 15.89 | 10.04 | 9 | 264534 | 120 | 56027404 |
Central pain syndrome | 15.87 | 10.04 | 11 | 264532 | 213 | 56027311 |
Libido disorder | 15.77 | 10.04 | 7 | 264536 | 53 | 56027471 |
Enterococcal infection | 15.75 | 10.04 | 7 | 264536 | 7177 | 56020347 |
Dysarthria | 15.66 | 10.04 | 115 | 264428 | 39435 | 55988089 |
Blood pressure abnormal | 15.62 | 10.04 | 25 | 264518 | 13635 | 56013889 |
Skin discolouration | 15.56 | 10.04 | 96 | 264447 | 34260 | 55993264 |
Renal cancer | 15.47 | 10.04 | 3 | 264540 | 5276 | 56022248 |
Device breakage | 15.34 | 10.04 | 15 | 264528 | 10132 | 56017392 |
Drug level decreased | 15.30 | 10.04 | 7 | 264536 | 7057 | 56020467 |
Bacterial infection | 15.25 | 10.04 | 37 | 264506 | 17293 | 56010231 |
Injection site abscess | 15.25 | 10.04 | 22 | 264521 | 1064 | 56026460 |
Staphylococcal bacteraemia | 15.18 | 10.04 | 3 | 264540 | 5206 | 56022318 |
Hypovolaemia | 15.17 | 10.04 | 14 | 264529 | 9721 | 56017803 |
International normalised ratio increased | 15.16 | 10.04 | 133 | 264410 | 43908 | 55983616 |
Gastrointestinal toxicity | 15.15 | 10.04 | 5 | 264538 | 6151 | 56021373 |
Diffuse large B-cell lymphoma | 15.13 | 10.04 | 7 | 264536 | 7009 | 56020515 |
Cholestasis | 15.07 | 10.04 | 70 | 264473 | 26843 | 56000681 |
Muscle spasticity | 15.03 | 10.04 | 46 | 264497 | 19914 | 56007610 |
Kounis syndrome | 14.98 | 10.04 | 24 | 264519 | 1274 | 56026250 |
Erythematotelangiectatic rosacea | 14.96 | 10.04 | 5 | 264538 | 15 | 56027509 |
Chronic kidney disease | 14.93 | 10.04 | 126 | 264417 | 41930 | 55985594 |
Nervous system disorder | 14.91 | 10.04 | 36 | 264507 | 16853 | 56010671 |
Peripheral sensory neuropathy | 14.90 | 10.04 | 7 | 264536 | 6949 | 56020575 |
Pancreatitis acute | 14.88 | 10.04 | 64 | 264479 | 25060 | 56002464 |
Joint injury | 14.80 | 10.04 | 66 | 264477 | 25588 | 56001936 |
Mood altered | 14.75 | 10.04 | 25 | 264518 | 13330 | 56014194 |
Dysphonia | 14.74 | 10.04 | 126 | 264417 | 41821 | 55985703 |
Vascular device infection | 14.74 | 10.04 | 4 | 264539 | 5586 | 56021938 |
Gastroenteritis viral | 14.72 | 10.04 | 48 | 264495 | 20376 | 56007148 |
Fistula | 14.69 | 10.04 | 12 | 264531 | 8843 | 56018681 |
Encephalitis | 14.67 | 10.04 | 10 | 264533 | 8080 | 56019444 |
Gastrointestinal ulcer | 14.66 | 10.04 | 29 | 264514 | 1818 | 56025706 |
Anterior chamber cell | 14.64 | 10.04 | 15 | 264528 | 506 | 56027018 |
Basal ganglion degeneration | 14.63 | 10.04 | 14 | 264529 | 434 | 56027090 |
Cholelithiasis | 14.57 | 10.04 | 117 | 264426 | 39347 | 55988177 |
Device malfunction | 14.56 | 10.04 | 34 | 264509 | 16102 | 56011422 |
Homicide | 14.48 | 10.04 | 13 | 264530 | 371 | 56027153 |
Tardive dyskinesia | 14.46 | 10.04 | 10 | 264533 | 8021 | 56019503 |
Meralgia paraesthetica | 14.39 | 10.04 | 12 | 264531 | 309 | 56027215 |
Pruritus | 14.39 | 10.04 | 1699 | 262844 | 314924 | 55712600 |
Nail operation | 14.37 | 10.04 | 18 | 264525 | 759 | 56026765 |
Retching | 14.34 | 10.04 | 26 | 264517 | 13504 | 56014020 |
Granuloma | 14.33 | 10.04 | 4 | 264539 | 5483 | 56022041 |
Diverticulitis | 14.32 | 10.04 | 104 | 264439 | 35748 | 55991776 |
Sebaceous gland infection | 14.30 | 10.04 | 9 | 264534 | 147 | 56027377 |
Myopathy | 14.27 | 10.04 | 15 | 264528 | 9797 | 56017727 |
Suspected suicide | 14.25 | 10.04 | 4 | 264539 | 5462 | 56022062 |
Immunosuppression | 14.23 | 10.04 | 10 | 264533 | 7954 | 56019570 |
Haemorrhoids | 14.22 | 10.04 | 48 | 264495 | 20158 | 56007366 |
Glycosylated haemoglobin increased | 14.17 | 10.04 | 19 | 264524 | 11146 | 56016378 |
Bone pain | 14.17 | 10.04 | 159 | 264384 | 50026 | 55977498 |
Pneumonia viral | 14.15 | 10.04 | 8 | 264535 | 7150 | 56020374 |
Therapy interrupted | 14.15 | 10.04 | 67 | 264476 | 25558 | 56001966 |
Hip fracture | 14.04 | 10.04 | 72 | 264471 | 26901 | 56000623 |
Congenital tricuspid valve atresia | 14.03 | 10.04 | 6 | 264537 | 41 | 56027483 |
Tooth disorder | 14.00 | 10.04 | 67 | 264476 | 25486 | 56002038 |
Device difficult to use | 13.98 | 10.04 | 18 | 264525 | 10743 | 56016781 |
Loss of personal independence in daily activities | 13.93 | 10.04 | 284 | 264259 | 81085 | 55946439 |
Basal cell carcinoma | 13.89 | 10.04 | 66 | 264477 | 25155 | 56002369 |
Mental impairment | 13.88 | 10.04 | 24 | 264519 | 12698 | 56014826 |
Normal newborn | 13.86 | 10.04 | 9 | 264534 | 7461 | 56020063 |
Lupus-like syndrome | 13.85 | 10.04 | 103 | 264440 | 12324 | 56015200 |
Epstein-Barr virus infection | 13.83 | 10.04 | 9 | 264534 | 7454 | 56020070 |
Skin cancer | 13.79 | 10.04 | 17 | 264526 | 10338 | 56017186 |
Renal disorder | 13.78 | 10.04 | 82 | 264461 | 29523 | 55998001 |
Granulocytopenia | 13.77 | 10.04 | 4 | 264539 | 5340 | 56022184 |
Salivary hypersecretion | 13.76 | 10.04 | 8 | 264535 | 7042 | 56020482 |
Walking aid user | 13.73 | 10.04 | 77 | 264466 | 8366 | 56019158 |
Injection site warmth | 13.68 | 10.04 | 29 | 264514 | 14214 | 56013310 |
Papulopustular rosacea | 13.68 | 10.04 | 5 | 264538 | 21 | 56027503 |
Acne | 13.68 | 10.04 | 52 | 264491 | 21084 | 56006440 |
Pulseless electrical activity | 13.67 | 10.04 | 8 | 264535 | 7016 | 56020508 |
Emotional disorder | 13.60 | 10.04 | 23 | 264520 | 12272 | 56015252 |
Injection site rash | 13.55 | 10.04 | 38 | 264505 | 16920 | 56010604 |
Palatal oedema | 13.53 | 10.04 | 14 | 264529 | 478 | 56027046 |
Haemophagocytic lymphohistiocytosis | 13.51 | 10.04 | 15 | 264528 | 9557 | 56017967 |
Arterial haemorrhage | 13.49 | 10.04 | 26 | 264517 | 1599 | 56025925 |
Porphyria | 13.45 | 10.04 | 9 | 264534 | 164 | 56027360 |
Pyoderma streptococcal | 13.45 | 10.04 | 4 | 264539 | 7 | 56027517 |
Wound infection pseudomonas | 13.41 | 10.04 | 23 | 264520 | 1292 | 56026232 |
Multiple fractures | 13.41 | 10.04 | 9 | 264534 | 7332 | 56020192 |
Dysuria | 13.33 | 10.04 | 87 | 264456 | 30642 | 55996882 |
Acquired porphyria | 13.32 | 10.04 | 5 | 264538 | 23 | 56027501 |
Porphyrins urine increased | 13.32 | 10.04 | 5 | 264538 | 23 | 56027501 |
Fear of injection | 13.29 | 10.04 | 7 | 264536 | 6508 | 56021016 |
Wrist deformity | 13.24 | 10.04 | 28 | 264515 | 1842 | 56025682 |
Conjunctival hyperaemia | 13.23 | 10.04 | 31 | 264512 | 2185 | 56025339 |
Hypertransaminasaemia | 13.13 | 10.04 | 3 | 264540 | 4704 | 56022820 |
Application site eczema | 13.10 | 10.04 | 3 | 264540 | 0 | 56027524 |
Pseudodiverticular disease | 13.10 | 10.04 | 3 | 264540 | 0 | 56027524 |
Dystonia | 13.04 | 10.04 | 24 | 264519 | 12397 | 56015127 |
Blood glucose abnormal | 13.02 | 10.04 | 9 | 264534 | 7219 | 56020305 |
Anal erosion | 12.98 | 10.04 | 5 | 264538 | 25 | 56027499 |
Product substitution issue | 12.98 | 10.04 | 31 | 264512 | 14568 | 56012956 |
Hypogammaglobulinaemia | 12.97 | 10.04 | 7 | 264536 | 6419 | 56021105 |
Myoclonus | 12.96 | 10.04 | 33 | 264510 | 15170 | 56012354 |
Exercise tolerance decreased | 12.96 | 10.04 | 4 | 264539 | 5134 | 56022390 |
Oedema peripheral | 12.95 | 10.04 | 665 | 263878 | 170589 | 55856935 |
Ulcer | 12.88 | 10.04 | 58 | 264485 | 22427 | 56005097 |
Bone marrow oedema | 12.87 | 10.04 | 20 | 264523 | 1034 | 56026490 |
Menstruation irregular | 12.86 | 10.04 | 7 | 264536 | 6389 | 56021135 |
Application site injury | 12.83 | 10.04 | 5 | 264538 | 26 | 56027498 |
Tumour lysis syndrome | 12.82 | 10.04 | 11 | 264532 | 7912 | 56019612 |
Erythema induratum | 12.77 | 10.04 | 9 | 264534 | 179 | 56027345 |
Drug level increased | 12.77 | 10.04 | 52 | 264491 | 20673 | 56006851 |
Diverticulum intestinal | 12.73 | 10.04 | 62 | 264481 | 6378 | 56021146 |
Blood bilirubin increased | 12.73 | 10.04 | 98 | 264445 | 33256 | 55994268 |
Iris transillumination defect | 12.71 | 10.04 | 7 | 264536 | 88 | 56027436 |
Haemolysis | 12.61 | 10.04 | 7 | 264536 | 6321 | 56021203 |
Intestinal haemorrhage | 12.58 | 10.04 | 41 | 264502 | 3505 | 56024019 |
Fracture | 12.54 | 10.04 | 43 | 264500 | 17975 | 56009549 |
Oesophageal carcinoma recurrent | 12.52 | 10.04 | 5 | 264538 | 28 | 56027496 |
Pharyngo-oesophageal diverticulum | 12.50 | 10.04 | 4 | 264539 | 10 | 56027514 |
Metabolic disorder | 12.49 | 10.04 | 5 | 264538 | 5456 | 56022068 |
Cystitis | 12.45 | 10.04 | 159 | 264384 | 48879 | 55978645 |
Exostosis | 12.45 | 10.04 | 116 | 264427 | 14827 | 56012697 |
Reticulocytosis | 12.44 | 10.04 | 8 | 264535 | 136 | 56027388 |
Hepatic cytolysis | 12.43 | 10.04 | 20 | 264523 | 10886 | 56016638 |
Viral upper respiratory tract infection | 12.42 | 10.04 | 67 | 264476 | 7175 | 56020349 |
Tissue infiltration | 12.40 | 10.04 | 15 | 264528 | 610 | 56026914 |
Spinal cord infection | 12.36 | 10.04 | 15 | 264528 | 612 | 56026912 |
Catheter site infection | 12.35 | 10.04 | 3 | 264540 | 4511 | 56023013 |
Staphylococcal infection | 12.34 | 10.04 | 115 | 264428 | 37503 | 55990021 |
Complication of device removal | 12.31 | 10.04 | 3 | 264540 | 4501 | 56023023 |
Glaucoma | 12.30 | 10.04 | 41 | 264502 | 17288 | 56010236 |
Injection site urticaria | 12.30 | 10.04 | 26 | 264517 | 12757 | 56014767 |
Spinal fracture | 12.26 | 10.04 | 38 | 264505 | 16386 | 56011138 |
Application site ulcer | 12.25 | 10.04 | 7 | 264536 | 95 | 56027429 |
Congestive cardiomyopathy | 12.25 | 10.04 | 6 | 264537 | 5813 | 56021711 |
Porphyrins stool increased | 12.24 | 10.04 | 5 | 264538 | 30 | 56027494 |
Irritability | 12.22 | 10.04 | 85 | 264458 | 29503 | 55998021 |
Partial seizures | 12.22 | 10.04 | 5 | 264538 | 5385 | 56022139 |
Eye irritation | 12.19 | 10.04 | 47 | 264496 | 18981 | 56008543 |
Transient ischaemic attack | 12.19 | 10.04 | 100 | 264443 | 33477 | 55994047 |
Hyperammonaemia | 12.18 | 10.04 | 4 | 264539 | 4936 | 56022588 |
Alanine aminotransferase increased | 12.14 | 10.04 | 341 | 264202 | 93321 | 55934203 |
Pneumothorax | 12.12 | 10.04 | 33 | 264510 | 14834 | 56012690 |
Pain in jaw | 12.04 | 10.04 | 125 | 264418 | 39911 | 55987613 |
Respiratory acidosis | 12.02 | 10.04 | 7 | 264536 | 6156 | 56021368 |
Parotid gland enlargement | 12.02 | 10.04 | 17 | 264526 | 807 | 56026717 |
Onychomadesis | 12.01 | 10.04 | 49 | 264494 | 4672 | 56022852 |
Pulmonary thrombosis | 12.01 | 10.04 | 12 | 264531 | 8025 | 56019499 |
Meteoropathy | 11.97 | 10.04 | 4 | 264539 | 12 | 56027512 |
Neurological procedural complication | 11.97 | 10.04 | 4 | 264539 | 12 | 56027512 |
Alpha tumour necrosis factor increased | 11.97 | 10.04 | 5 | 264538 | 32 | 56027492 |
Sinus bradycardia | 11.96 | 10.04 | 29 | 264514 | 13557 | 56013967 |
Coordination abnormal | 11.87 | 10.04 | 26 | 264517 | 12595 | 56014929 |
Joint stiffness | 11.82 | 10.04 | 233 | 264310 | 35192 | 55992332 |
Cardiac massage | 11.73 | 10.04 | 4 | 264539 | 13 | 56027511 |
Immune reconstitution inflammatory syndrome | 11.72 | 10.04 | 6 | 264537 | 5668 | 56021856 |
Vertigo | 11.71 | 10.04 | 183 | 264360 | 54389 | 55973135 |
Nervousness | 11.67 | 10.04 | 84 | 264459 | 28931 | 55998593 |
Abortion induced | 11.66 | 10.04 | 17 | 264526 | 9628 | 56017896 |
Colitis ulcerative | 11.65 | 10.04 | 67 | 264476 | 24324 | 56003200 |
Blood magnesium decreased | 11.55 | 10.04 | 24 | 264519 | 11850 | 56015674 |
Alanine aminotransferase abnormal | 11.55 | 10.04 | 3 | 264540 | 4312 | 56023212 |
Hypoproteinaemia | 11.54 | 10.04 | 27 | 264516 | 1901 | 56025623 |
Underdose | 11.49 | 10.04 | 65 | 264478 | 23692 | 56003832 |
Unintended pregnancy | 11.47 | 10.04 | 5 | 264538 | 5186 | 56022338 |
Pneumonitis | 11.46 | 10.04 | 94 | 264449 | 31470 | 55996054 |
Skin fissures | 11.45 | 10.04 | 17 | 264526 | 9556 | 56017968 |
Hyperlipidaemia | 11.43 | 10.04 | 45 | 264498 | 18064 | 56009460 |
Device leakage | 11.40 | 10.04 | 8 | 264535 | 6367 | 56021157 |
Peptic ulcer | 11.34 | 10.04 | 44 | 264499 | 4100 | 56023424 |
Perforation bile duct | 11.30 | 10.04 | 4 | 264539 | 15 | 56027509 |
Blood pressure systolic increased | 11.28 | 10.04 | 130 | 264413 | 40706 | 55986818 |
Oesophagitis ulcerative | 11.28 | 10.04 | 13 | 264530 | 502 | 56027022 |
Immune system disorder | 11.23 | 10.04 | 15 | 264528 | 8812 | 56018712 |
Brain oedema | 11.16 | 10.04 | 29 | 264514 | 13242 | 56014282 |
Pollakiuria | 11.11 | 10.04 | 71 | 264472 | 25131 | 56002393 |
Gastrooesophageal reflux disease | 11.08 | 10.04 | 302 | 264241 | 82955 | 55944569 |
Venous valve ruptured | 11.03 | 10.04 | 3 | 264540 | 3 | 56027521 |
Anger | 11.02 | 10.04 | 24 | 264519 | 11648 | 56015876 |
Acute graft versus host disease | 10.99 | 10.04 | 3 | 264540 | 4172 | 56023352 |
Paranasal cyst | 10.98 | 10.04 | 11 | 264532 | 361 | 56027163 |
Hemiplegia | 10.98 | 10.04 | 14 | 264529 | 8390 | 56019134 |
White blood cell count abnormal | 10.98 | 10.04 | 7 | 264536 | 5860 | 56021664 |
Electrocardiogram QRS complex prolonged | 10.97 | 10.04 | 6 | 264537 | 5461 | 56022063 |
Therapeutic response decreased | 10.96 | 10.04 | 178 | 264365 | 52580 | 55974944 |
Intentional product misuse | 10.95 | 10.04 | 173 | 264370 | 51331 | 55976193 |
Head titubation | 10.92 | 10.04 | 16 | 264527 | 785 | 56026739 |
Necrotising fasciitis | 10.90 | 10.04 | 33 | 264510 | 2712 | 56024812 |
Appetite disorder | 10.86 | 10.04 | 9 | 264534 | 6584 | 56020940 |
Stillbirth | 10.85 | 10.04 | 8 | 264535 | 6206 | 56021318 |
Bone lesion | 10.83 | 10.04 | 6 | 264537 | 5424 | 56022100 |
Joint arthroplasty | 10.82 | 10.04 | 32 | 264511 | 2596 | 56024928 |
Body temperature decreased | 10.80 | 10.04 | 46 | 264497 | 18062 | 56009462 |
Breath sounds abnormal | 10.76 | 10.04 | 16 | 264527 | 8991 | 56018533 |
Limb discomfort | 10.74 | 10.04 | 77 | 264466 | 26545 | 56000979 |
Osteoporosis | 10.69 | 10.04 | 176 | 264367 | 51876 | 55975648 |
Hypothermia | 10.68 | 10.04 | 27 | 264516 | 12443 | 56015081 |
Cardiogenic shock | 10.67 | 10.04 | 40 | 264503 | 16285 | 56011239 |
Heart rate decreased | 10.67 | 10.04 | 130 | 264413 | 40297 | 55987227 |
Delusion | 10.63 | 10.04 | 23 | 264520 | 11192 | 56016332 |
Thinking abnormal | 10.63 | 10.04 | 19 | 264524 | 9922 | 56017602 |
Atrioventricular block | 10.62 | 10.04 | 10 | 264533 | 6877 | 56020647 |
Seroma | 10.62 | 10.04 | 26 | 264517 | 1885 | 56025639 |
Sinus headache | 10.61 | 10.04 | 5 | 264538 | 4953 | 56022571 |
Lip scab | 10.57 | 10.04 | 3 | 264540 | 4 | 56027520 |
Neonatal gastrointestinal haemorrhage | 10.55 | 10.04 | 4 | 264539 | 19 | 56027505 |
Vaginal ulceration | 10.48 | 10.04 | 11 | 264532 | 382 | 56027142 |
Gastrointestinal procedural complication | 10.47 | 10.04 | 8 | 264535 | 181 | 56027343 |
Accidental overdose | 10.43 | 10.04 | 55 | 264488 | 20406 | 56007118 |
Feeling hot | 10.42 | 10.04 | 136 | 264407 | 41651 | 55985873 |
Blood pressure diastolic decreased | 10.39 | 10.04 | 51 | 264492 | 19272 | 56008252 |
pH body fluid decreased | 10.39 | 10.04 | 4 | 264539 | 20 | 56027504 |
Aspartate aminotransferase increased | 10.38 | 10.04 | 302 | 264241 | 82300 | 55945224 |
Feeling jittery | 10.38 | 10.04 | 26 | 264517 | 12020 | 56015504 |
Analgesic drug level increased | 10.35 | 10.04 | 25 | 264518 | 1797 | 56025727 |
Hypophagia | 10.34 | 10.04 | 192 | 264351 | 28684 | 55998840 |
Pharyngitis streptococcal | 10.29 | 10.04 | 18 | 264525 | 9480 | 56018044 |
Pneumonitis chemical | 10.29 | 10.04 | 8 | 264535 | 186 | 56027338 |
Hemiparesis | 10.28 | 10.04 | 59 | 264484 | 21431 | 56006093 |
Atrial flutter | 10.28 | 10.04 | 17 | 264526 | 9152 | 56018372 |
Stress ulcer | 10.25 | 10.04 | 5 | 264538 | 48 | 56027476 |
Myelodysplastic syndrome | 10.21 | 10.04 | 41 | 264502 | 16365 | 56011159 |
Anosmia | 10.18 | 10.04 | 4 | 264539 | 4415 | 56023109 |
Motor dysfunction | 10.18 | 10.04 | 18 | 264525 | 9439 | 56018085 |
Musculoskeletal disorder | 10.16 | 10.04 | 136 | 264407 | 19011 | 56008513 |
Extravascular haemolysis | 10.16 | 10.04 | 5 | 264538 | 49 | 56027475 |
Restless legs syndrome | 10.14 | 10.04 | 43 | 264500 | 16904 | 56010620 |
Anaesthesia | 10.11 | 10.04 | 11 | 264532 | 398 | 56027126 |
Carbohydrate antigen 15-3 | 10.09 | 10.04 | 6 | 264537 | 88 | 56027436 |
Cholecystitis chronic | 10.09 | 10.04 | 19 | 264524 | 9729 | 56017795 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Embolia cutis medicamentosa | 257.23 | 10.40 | 68 | 77415 | 167 | 31619694 |
Ankylosing spondylitis | 242.47 | 10.40 | 161 | 77322 | 5720 | 31614141 |
Death | 241.28 | 10.40 | 318 | 77165 | 360251 | 31259610 |
Melaena | 214.34 | 10.40 | 327 | 77156 | 32327 | 31587534 |
Gastric ulcer | 202.99 | 10.40 | 213 | 77270 | 14421 | 31605440 |
Duodenal ulcer | 142.38 | 10.40 | 146 | 77337 | 9618 | 31610243 |
Onychoclasis | 131.07 | 10.40 | 71 | 77412 | 1724 | 31618137 |
Off label use | 124.85 | 10.40 | 434 | 77049 | 346840 | 31273021 |
Febrile neutropenia | 119.74 | 10.40 | 75 | 77408 | 121774 | 31498087 |
Kounis syndrome | 115.93 | 10.40 | 69 | 77414 | 2015 | 31617846 |
Angioedema | 106.08 | 10.40 | 246 | 77237 | 33372 | 31586489 |
Anaphylactic shock | 103.32 | 10.40 | 149 | 77334 | 13996 | 31605865 |
Inflammation | 100.59 | 10.40 | 203 | 77280 | 25038 | 31594823 |
Gastritis erosive | 98.37 | 10.40 | 93 | 77390 | 5546 | 31614315 |
Neutropenia | 93.22 | 10.40 | 124 | 77359 | 140240 | 31479621 |
Large intestinal stenosis | 90.73 | 10.40 | 52 | 77431 | 1413 | 31618448 |
Gastric ulcer haemorrhage | 86.53 | 10.40 | 83 | 77400 | 5040 | 31614821 |
Arthralgia | 84.96 | 10.40 | 647 | 76836 | 150777 | 31469084 |
Pain | 81.93 | 10.40 | 755 | 76728 | 186004 | 31433857 |
Large intestinal ulcer | 80.70 | 10.40 | 52 | 77431 | 1753 | 31618108 |
Tooth loss | 80.14 | 10.40 | 69 | 77414 | 3639 | 31616222 |
Psoriatic arthropathy | 75.77 | 10.40 | 157 | 77326 | 19726 | 31600135 |
Urticaria | 69.65 | 10.40 | 302 | 77181 | 57215 | 31562646 |
Lymphoma | 69.52 | 10.40 | 108 | 77375 | 10835 | 31609026 |
Pruritus | 69.14 | 10.40 | 533 | 76950 | 124634 | 31495227 |
Intestinal diaphragm disease | 68.50 | 10.40 | 25 | 77458 | 224 | 31619637 |
Duodenal ulcer perforation | 67.51 | 10.40 | 44 | 77439 | 1513 | 31618348 |
Neck pain | 67.22 | 10.40 | 163 | 77320 | 22747 | 31597114 |
Plasma cell myeloma | 67.18 | 10.40 | 27 | 77456 | 56504 | 31563357 |
Joint swelling | 63.51 | 10.40 | 279 | 77204 | 53152 | 31566709 |
Musculoskeletal stiffness | 62.86 | 10.40 | 233 | 77250 | 41092 | 31578769 |
Gastric haemorrhage | 62.61 | 10.40 | 97 | 77386 | 9708 | 31610153 |
Cardiac failure congestive | 62.58 | 10.40 | 61 | 77422 | 79326 | 31540535 |
Anaphylactic reaction | 61.29 | 10.40 | 185 | 77298 | 29368 | 31590493 |
Back pain | 60.45 | 10.40 | 466 | 77017 | 108947 | 31510914 |
Haematemesis | 60.34 | 10.40 | 168 | 77315 | 25485 | 31594376 |
Type I hypersensitivity | 59.26 | 10.40 | 36 | 77447 | 1092 | 31618769 |
Sacroiliitis | 57.96 | 10.40 | 38 | 77445 | 1320 | 31618541 |
Pyloric stenosis | 57.81 | 10.40 | 31 | 77452 | 737 | 31619124 |
Upper gastrointestinal haemorrhage | 57.69 | 10.40 | 155 | 77328 | 23028 | 31596833 |
Thrombocytopenia | 56.90 | 10.40 | 170 | 77313 | 142577 | 31477284 |
Macrocephaly | 55.73 | 10.40 | 26 | 77457 | 454 | 31619407 |
Abdominal pain upper | 55.20 | 10.40 | 305 | 77178 | 63697 | 31556164 |
Tubulointerstitial nephritis and uveitis syndrome | 52.81 | 10.40 | 16 | 77467 | 74 | 31619787 |
Fractional exhaled nitric oxide increased | 51.79 | 10.40 | 27 | 77456 | 605 | 31619256 |
Toxicity to various agents | 51.65 | 10.40 | 248 | 77235 | 181239 | 31438622 |
C-reactive protein increased | 50.39 | 10.40 | 244 | 77239 | 48406 | 31571455 |
Metastases to stomach | 49.57 | 10.40 | 15 | 77468 | 69 | 31619792 |
Application site rash | 49.28 | 10.40 | 28 | 77455 | 748 | 31619113 |
Periorbital oedema | 48.97 | 10.40 | 51 | 77432 | 3420 | 31616441 |
Antidepressant drug level above therapeutic | 48.69 | 10.40 | 19 | 77464 | 208 | 31619653 |
Acute kidney injury | 48.65 | 10.40 | 956 | 76527 | 278758 | 31341103 |
Gastric ulcer perforation | 47.95 | 10.40 | 30 | 77453 | 960 | 31618901 |
Disease progression | 47.69 | 10.40 | 93 | 77390 | 90371 | 31529490 |
Analgesic drug level above therapeutic | 46.98 | 10.40 | 20 | 77463 | 278 | 31619583 |
Spinal pain | 45.88 | 10.40 | 60 | 77423 | 5135 | 31614726 |
Arthritis | 43.83 | 10.40 | 157 | 77326 | 27228 | 31592633 |
Mucosal erosion | 42.73 | 10.40 | 26 | 77457 | 791 | 31619070 |
Head discomfort | 42.43 | 10.40 | 49 | 77434 | 3690 | 31616171 |
Sensation of foreign body | 42.12 | 10.40 | 38 | 77445 | 2133 | 31617728 |
Myoglobin blood increased | 41.58 | 10.40 | 40 | 77443 | 2437 | 31617424 |
Ductus arteriosus premature closure | 41.10 | 10.40 | 17 | 77466 | 219 | 31619642 |
Muscle swelling | 40.46 | 10.40 | 19 | 77464 | 337 | 31619524 |
Ligament calcification | 38.83 | 10.40 | 16 | 77467 | 204 | 31619657 |
Aspirin-exacerbated respiratory disease | 38.58 | 10.40 | 19 | 77464 | 376 | 31619485 |
Seronegative arthritis | 38.49 | 10.40 | 26 | 77457 | 950 | 31618911 |
Plantar fasciitis | 36.84 | 10.40 | 31 | 77452 | 1584 | 31618277 |
Hospitalisation | 36.17 | 10.40 | 41 | 77442 | 49766 | 31570095 |
Erythema | 36.12 | 10.40 | 327 | 77156 | 80078 | 31539783 |
Injection site necrosis | 35.93 | 10.40 | 18 | 77465 | 370 | 31619491 |
Sepsis | 35.82 | 10.40 | 221 | 77262 | 151708 | 31468153 |
Product dose omission issue | 35.71 | 10.40 | 135 | 77348 | 105451 | 31514410 |
Atrial fibrillation | 35.62 | 10.40 | 150 | 77333 | 113633 | 31506228 |
Gastrointestinal erosion | 35.41 | 10.40 | 18 | 77465 | 382 | 31619479 |
Ulcerative keratitis | 35.10 | 10.40 | 30 | 77453 | 1566 | 31618295 |
Nephrotic syndrome | 34.92 | 10.40 | 62 | 77421 | 6941 | 31612920 |
Uveitis | 34.84 | 10.40 | 61 | 77422 | 6755 | 31613106 |
Erythema multiforme | 34.66 | 10.40 | 67 | 77416 | 8004 | 31611857 |
Bronchospasm | 33.68 | 10.40 | 75 | 77408 | 9897 | 31609964 |
Neoplasm malignant | 33.30 | 10.40 | 112 | 77371 | 18819 | 31601042 |
Glomerulonephritis minimal lesion | 32.79 | 10.40 | 18 | 77465 | 449 | 31619412 |
Psoriasis | 32.18 | 10.40 | 210 | 77273 | 46509 | 31573352 |
Drug tolerance decreased | 32.18 | 10.40 | 30 | 77453 | 1757 | 31618104 |
Cerebrovascular accident | 32.11 | 10.40 | 94 | 77389 | 79390 | 31540471 |
Pneumonia | 31.86 | 10.40 | 603 | 76880 | 334709 | 31285152 |
Blood pressure measurement | 31.60 | 10.40 | 13 | 77470 | 165 | 31619696 |
Exostosis | 31.44 | 10.40 | 43 | 77440 | 3843 | 31616018 |
Cerebral atrophy congenital | 31.14 | 10.40 | 10 | 77473 | 58 | 31619803 |
Corneal thinning | 30.46 | 10.40 | 12 | 77471 | 135 | 31619726 |
Hypomagnesaemia | 30.44 | 10.40 | 5 | 77478 | 19053 | 31600808 |
Duodenal ulcer haemorrhage | 30.36 | 10.40 | 47 | 77436 | 4699 | 31615162 |
Mastoid abscess | 30.10 | 10.40 | 6 | 77477 | 0 | 31619861 |
Peritonitis | 29.95 | 10.40 | 94 | 77389 | 15233 | 31604628 |
Drug interaction | 29.79 | 10.40 | 693 | 76790 | 207850 | 31412011 |
Peptic ulcer | 29.64 | 10.40 | 34 | 77449 | 2542 | 31617319 |
Gastrointestinal haemorrhage | 29.43 | 10.40 | 320 | 77163 | 82229 | 31537632 |
Blister | 29.31 | 10.40 | 115 | 77368 | 20821 | 31599040 |
Faeces discoloured | 29.23 | 10.40 | 87 | 77396 | 13699 | 31606162 |
Secretion discharge | 28.98 | 10.40 | 47 | 77436 | 4890 | 31614971 |
Toxic epidermal necrolysis | 28.77 | 10.40 | 109 | 77374 | 19415 | 31600446 |
Pancytopenia | 28.64 | 10.40 | 113 | 77370 | 87203 | 31532658 |
Erosive duodenitis | 28.51 | 10.40 | 25 | 77458 | 1351 | 31618510 |
Conjunctival hyperaemia | 28.50 | 10.40 | 31 | 77452 | 2185 | 31617676 |
Lymphocyte stimulation test positive | 28.40 | 10.40 | 19 | 77464 | 683 | 31619178 |
Intestinal atony | 28.39 | 10.40 | 8 | 77475 | 27 | 31619834 |
Nephrolithiasis | 28.21 | 10.40 | 137 | 77346 | 27202 | 31592659 |
Haematochezia | 27.94 | 10.40 | 182 | 77301 | 40282 | 31579579 |
Tubulointerstitial nephritis | 27.87 | 10.40 | 104 | 77379 | 18392 | 31601469 |
Alopecia | 27.63 | 10.40 | 112 | 77371 | 20583 | 31599278 |
Cytokine release syndrome | 27.41 | 10.40 | 4 | 77479 | 16638 | 31603223 |
Fibromyalgia | 27.10 | 10.40 | 34 | 77449 | 2792 | 31617069 |
Blood urea increased | 26.85 | 10.40 | 141 | 77342 | 28871 | 31590990 |
Application site reaction | 26.46 | 10.40 | 15 | 77468 | 399 | 31619462 |
Gastritis | 26.44 | 10.40 | 109 | 77374 | 20183 | 31599678 |
Microcytic anaemia | 26.41 | 10.40 | 29 | 77454 | 2066 | 31617795 |
Oral pruritus | 25.87 | 10.40 | 13 | 77470 | 269 | 31619592 |
Gingivitis ulcerative | 25.27 | 10.40 | 8 | 77475 | 44 | 31619817 |
Malignant mesenteric neoplasm | 25.27 | 10.40 | 8 | 77475 | 44 | 31619817 |
Nerve stimulation test abnormal | 25.08 | 10.40 | 5 | 77478 | 0 | 31619861 |
Hypotension | 25.01 | 10.40 | 351 | 77132 | 204267 | 31415594 |
Application site swelling | 24.90 | 10.40 | 12 | 77471 | 226 | 31619635 |
Blood lactate dehydrogenase increased | 24.75 | 10.40 | 107 | 77376 | 20232 | 31599629 |
Platelet dysfunction | 24.52 | 10.40 | 12 | 77471 | 234 | 31619627 |
Cytomegalovirus infection | 24.52 | 10.40 | 15 | 77468 | 24692 | 31595169 |
Neurotoxicity | 24.32 | 10.40 | 5 | 77478 | 16221 | 31603640 |
Nightmare | 24.24 | 10.40 | 75 | 77408 | 12062 | 31607799 |
Sciatic nerve injury | 24.15 | 10.40 | 9 | 77474 | 86 | 31619775 |
Corneal perforation | 24.11 | 10.40 | 11 | 77472 | 182 | 31619679 |
Fatigue | 24.04 | 10.40 | 630 | 76853 | 334576 | 31285285 |
Anuria | 23.79 | 10.40 | 65 | 77418 | 9749 | 31610112 |
Laryngeal discomfort | 23.69 | 10.40 | 11 | 77472 | 190 | 31619671 |
Angiocardiogram | 23.69 | 10.40 | 11 | 77472 | 190 | 31619671 |
Cardiac septal defect | 23.68 | 10.40 | 12 | 77471 | 253 | 31619608 |
Hyperhidrosis | 23.44 | 10.40 | 260 | 77223 | 67133 | 31552728 |
Migraine | 23.28 | 10.40 | 82 | 77401 | 14098 | 31605763 |
Deep vein thrombosis | 22.98 | 10.40 | 74 | 77409 | 60662 | 31559199 |
Leukopenia | 22.91 | 10.40 | 69 | 77414 | 57759 | 31562102 |
Disability | 22.90 | 10.40 | 41 | 77442 | 4620 | 31615241 |
Neuropathy peripheral | 22.88 | 10.40 | 101 | 77382 | 75548 | 31544313 |
Electrocardiogram QT prolonged | 22.77 | 10.40 | 36 | 77447 | 37951 | 31581910 |
Platelet function test abnormal | 22.71 | 10.40 | 9 | 77474 | 103 | 31619758 |
Corneal epithelium defect | 22.62 | 10.40 | 13 | 77470 | 355 | 31619506 |
Medium-chain acyl-coenzyme A dehydrogenase deficiency | 22.34 | 10.40 | 7 | 77476 | 37 | 31619824 |
Renal failure neonatal | 22.25 | 10.40 | 9 | 77474 | 109 | 31619752 |
Swelling | 22.22 | 10.40 | 162 | 77321 | 37196 | 31582665 |
Fragile X syndrome | 22.18 | 10.40 | 7 | 77476 | 38 | 31619823 |
Product administered at inappropriate site | 22.16 | 10.40 | 25 | 77458 | 1835 | 31618026 |
Jejunal ulcer perforation | 22.08 | 10.40 | 8 | 77475 | 70 | 31619791 |
Palmoplantar pustulosis | 21.89 | 10.40 | 9 | 77474 | 114 | 31619747 |
Inflammatory bowel disease | 21.88 | 10.40 | 29 | 77454 | 2514 | 31617347 |
Mental status changes | 21.64 | 10.40 | 34 | 77449 | 35934 | 31583927 |
Shock | 21.61 | 10.40 | 111 | 77372 | 22534 | 31597327 |
Leptotrichia infection | 21.60 | 10.40 | 8 | 77475 | 75 | 31619786 |
Subacute endocarditis | 21.60 | 10.40 | 7 | 77476 | 42 | 31619819 |
Iris hypopigmentation | 21.60 | 10.40 | 7 | 77476 | 42 | 31619819 |
Weight bearing difficulty | 21.14 | 10.40 | 18 | 77465 | 935 | 31618926 |
Mast cell activation syndrome | 21.11 | 10.40 | 10 | 77473 | 181 | 31619680 |
Hypoaldosteronism | 21.11 | 10.40 | 10 | 77473 | 181 | 31619680 |
Right-to-left cardiac shunt | 21.06 | 10.40 | 8 | 77475 | 81 | 31619780 |
Factor VIII deficiency | 20.89 | 10.40 | 9 | 77474 | 129 | 31619732 |
Anorgasmia | 20.69 | 10.40 | 16 | 77467 | 724 | 31619137 |
Cryopyrin associated periodic syndrome | 20.55 | 10.40 | 8 | 77475 | 87 | 31619774 |
Gastric perforation | 20.45 | 10.40 | 27 | 77456 | 2332 | 31617529 |
Intervertebral disc compression | 20.27 | 10.40 | 11 | 77472 | 268 | 31619593 |
Duodenal stenosis | 20.25 | 10.40 | 10 | 77473 | 199 | 31619662 |
Suicide attempt | 20.17 | 10.40 | 158 | 77325 | 37090 | 31582771 |
Hypoglycaemia | 20.03 | 10.40 | 61 | 77422 | 50885 | 31568976 |
Body mass index abnormal | 19.89 | 10.40 | 9 | 77474 | 146 | 31619715 |
Pulmonary embolism | 19.61 | 10.40 | 118 | 77365 | 81528 | 31538333 |
Completed suicide | 19.58 | 10.40 | 137 | 77346 | 91377 | 31528484 |
Trisomy 8 | 19.55 | 10.40 | 7 | 77476 | 59 | 31619802 |
Intentional product use issue | 19.46 | 10.40 | 59 | 77424 | 49288 | 31570573 |
Application site erythema | 19.44 | 10.40 | 25 | 77458 | 2104 | 31617757 |
Omental necrosis | 19.42 | 10.40 | 6 | 77477 | 30 | 31619831 |
Application site eczema | 19.29 | 10.40 | 5 | 77478 | 11 | 31619850 |
Gastrointestinal ulcer | 19.20 | 10.40 | 22 | 77461 | 1643 | 31618218 |
Seizure | 19.14 | 10.40 | 154 | 77329 | 99614 | 31520247 |
Mesenteric neoplasm | 19.10 | 10.40 | 6 | 77477 | 32 | 31619829 |
Intestinal congestion | 18.99 | 10.40 | 5 | 77478 | 12 | 31619849 |
Eastern Cooperative Oncology Group performance status | 18.95 | 10.40 | 6 | 77477 | 33 | 31619828 |
Necrotising fasciitis | 18.87 | 10.40 | 32 | 77451 | 3454 | 31616407 |
Kidney duplex | 18.85 | 10.40 | 12 | 77471 | 396 | 31619465 |
Joint space narrowing | 18.61 | 10.40 | 8 | 77475 | 114 | 31619747 |
Neuroleptic malignant syndrome | 18.54 | 10.40 | 9 | 77474 | 16860 | 31603001 |
Tissue infiltration | 18.33 | 10.40 | 7 | 77476 | 72 | 31619789 |
Eschar | 18.25 | 10.40 | 14 | 77469 | 626 | 31619235 |
Pseudarthrosis | 18.24 | 10.40 | 7 | 77476 | 73 | 31619788 |
Contraindicated product administered | 18.23 | 10.40 | 96 | 77387 | 19676 | 31600185 |
Secondary amyloidosis | 17.99 | 10.40 | 7 | 77476 | 76 | 31619785 |
Face oedema | 17.96 | 10.40 | 62 | 77421 | 10554 | 31609307 |
Atrial septal defect | 17.92 | 10.40 | 47 | 77436 | 6880 | 31612981 |
Cardiogenic shock | 17.89 | 10.40 | 17 | 77466 | 22391 | 31597470 |
Hypoxia | 17.87 | 10.40 | 63 | 77420 | 50250 | 31569611 |
Twin pregnancy | 17.83 | 10.40 | 4 | 77479 | 3 | 31619858 |
Hypoosmolar state | 17.75 | 10.40 | 7 | 77476 | 79 | 31619782 |
Nasopharyngitis | 17.63 | 10.40 | 234 | 77249 | 63011 | 31556850 |
Acute myeloid leukaemia | 17.62 | 10.40 | 12 | 77471 | 18660 | 31601201 |
Incorrect product administration duration | 17.61 | 10.40 | 35 | 77448 | 4267 | 31615594 |
Musculoskeletal pain | 17.53 | 10.40 | 129 | 77354 | 29699 | 31590162 |
Abdominal lymphadenopathy | 17.50 | 10.40 | 15 | 77468 | 786 | 31619075 |
Oropharyngeal discomfort | 17.41 | 10.40 | 27 | 77456 | 2704 | 31617157 |
Cytopenia | 17.34 | 10.40 | 3 | 77480 | 11007 | 31608854 |
Intestinal ulcer | 17.16 | 10.40 | 15 | 77468 | 807 | 31619054 |
Gastritis haemorrhagic | 17.16 | 10.40 | 19 | 77464 | 1366 | 31618495 |
Hypervolaemia | 16.86 | 10.40 | 12 | 77471 | 18239 | 31601622 |
Mobility decreased | 16.84 | 10.40 | 120 | 77363 | 27349 | 31592512 |
Dactylitis | 16.84 | 10.40 | 15 | 77468 | 828 | 31619033 |
Pallor | 16.80 | 10.40 | 103 | 77380 | 22321 | 31597540 |
Bacteroides infection | 16.66 | 10.40 | 7 | 77476 | 94 | 31619767 |
Grip strength decreased | 16.64 | 10.40 | 26 | 77457 | 2620 | 31617241 |
Mallory-Weiss syndrome | 16.51 | 10.40 | 18 | 77465 | 1272 | 31618589 |
Drug resistance | 16.28 | 10.40 | 20 | 77463 | 23433 | 31596428 |
Oropharyngeal pain | 16.20 | 10.40 | 132 | 77351 | 31351 | 31588510 |
Muscle abscess | 16.15 | 10.40 | 12 | 77471 | 511 | 31619350 |
Arthritis bacterial | 16.04 | 10.40 | 35 | 77448 | 4555 | 31615306 |
Large intestine perforation | 16.01 | 10.40 | 48 | 77435 | 7588 | 31612273 |
Red blood cell sedimentation rate decreased | 15.86 | 10.40 | 6 | 77477 | 60 | 31619801 |
Gastric mucosa erythema | 15.82 | 10.40 | 9 | 77474 | 241 | 31619620 |
Respiratory failure | 15.81 | 10.40 | 165 | 77318 | 101284 | 31518577 |
Stevens-Johnson syndrome | 15.78 | 10.40 | 84 | 77399 | 17288 | 31602573 |
Intestinal metaplasia | 15.72 | 10.40 | 5 | 77478 | 28 | 31619833 |
Wound secretion | 15.70 | 10.40 | 24 | 77459 | 2373 | 31617488 |
Cardio-respiratory arrest | 15.67 | 10.40 | 69 | 77414 | 51657 | 31568204 |
Application site vesicles | 15.67 | 10.40 | 12 | 77471 | 535 | 31619326 |
Ureteral disorder | 15.60 | 10.40 | 8 | 77475 | 173 | 31619688 |
Cognitive disorder | 15.53 | 10.40 | 23 | 77460 | 24900 | 31594961 |
Lipoma | 15.49 | 10.40 | 19 | 77464 | 1524 | 31618337 |
Gastric mucosal lesion | 15.48 | 10.40 | 12 | 77471 | 545 | 31619316 |
Gastrointestinal mucosal exfoliation | 15.44 | 10.40 | 7 | 77476 | 114 | 31619747 |
Duodenal perforation | 15.44 | 10.40 | 17 | 77466 | 1215 | 31618646 |
Abdominal pain | 15.31 | 10.40 | 466 | 77017 | 145486 | 31474375 |
Diabetes mellitus | 15.30 | 10.40 | 53 | 77430 | 42503 | 31577358 |
Application site oedema | 15.29 | 10.40 | 5 | 77478 | 31 | 31619830 |
Ciliary hyperaemia | 15.29 | 10.40 | 5 | 77478 | 31 | 31619830 |
CADASIL | 15.27 | 10.40 | 6 | 77477 | 67 | 31619794 |
Full blood count decreased | 15.12 | 10.40 | 11 | 77472 | 16529 | 31603332 |
Product used for unknown indication | 15.12 | 10.40 | 14 | 77469 | 813 | 31619048 |
Nikolsky's sign | 15.08 | 10.40 | 8 | 77475 | 186 | 31619675 |
Leucine aminopeptidase increased | 15.05 | 10.40 | 3 | 77480 | 0 | 31619861 |
Internal limiting membrane peeling | 15.05 | 10.40 | 3 | 77480 | 0 | 31619861 |
Persistent corneal epithelial defect | 15.02 | 10.40 | 5 | 77478 | 33 | 31619828 |
Undifferentiated connective tissue disease | 15.02 | 10.40 | 5 | 77478 | 33 | 31619828 |
Metastases to lung | 14.96 | 10.40 | 50 | 77433 | 8372 | 31611489 |
Magnetic resonance imaging spinal abnormal | 14.96 | 10.40 | 6 | 77477 | 71 | 31619790 |
Encephalopathy | 14.93 | 10.40 | 36 | 77447 | 32438 | 31587423 |
Schizophrenia | 14.92 | 10.40 | 4 | 77479 | 10826 | 31609035 |
Myelodysplastic syndrome | 14.92 | 10.40 | 15 | 77468 | 19236 | 31600625 |
Application site hypersensitivity | 14.81 | 10.40 | 7 | 77476 | 126 | 31619735 |
Bradycardia | 14.72 | 10.40 | 104 | 77379 | 69223 | 31550638 |
Discoloured vomit | 14.61 | 10.40 | 11 | 77472 | 478 | 31619383 |
Visual evoked potentials abnormal | 14.59 | 10.40 | 6 | 77477 | 76 | 31619785 |
Renal tubular necrosis | 14.54 | 10.40 | 73 | 77410 | 14686 | 31605175 |
Transplant rejection | 14.53 | 10.40 | 3 | 77480 | 9705 | 31610156 |
Jaundice | 14.52 | 10.40 | 125 | 77358 | 30162 | 31589699 |
Skin ulcer | 14.47 | 10.40 | 91 | 77392 | 19894 | 31599967 |
Desmoid tumour | 14.47 | 10.40 | 7 | 77476 | 133 | 31619728 |
Oral mucosa erosion | 14.42 | 10.40 | 14 | 77469 | 863 | 31618998 |
Gastric disorder | 14.30 | 10.40 | 61 | 77422 | 11467 | 31608394 |
Sedation | 14.14 | 10.40 | 87 | 77396 | 18878 | 31600983 |
Rash erythematous | 13.96 | 10.40 | 99 | 77384 | 22528 | 31597333 |
Energy increased | 13.91 | 10.40 | 16 | 77467 | 1200 | 31618661 |
Chronic obstructive pulmonary disease | 13.83 | 10.40 | 60 | 77423 | 45106 | 31574755 |
Pain in extremity | 13.83 | 10.40 | 377 | 77106 | 115826 | 31504035 |
Anxiety | 13.80 | 10.40 | 149 | 77334 | 90884 | 31528977 |
Retroperitoneal fibrosis | 13.79 | 10.40 | 9 | 77474 | 310 | 31619551 |
Sciatic nerve palsy | 13.68 | 10.40 | 5 | 77478 | 45 | 31619816 |
Tongue oedema | 13.63 | 10.40 | 24 | 77459 | 2669 | 31617192 |
Microcephaly | 13.58 | 10.40 | 13 | 77470 | 787 | 31619074 |
Costovertebral angle tenderness | 13.56 | 10.40 | 6 | 77477 | 92 | 31619769 |
Deafness congenital | 13.56 | 10.40 | 6 | 77477 | 92 | 31619769 |
Retinal toxicity | 13.54 | 10.40 | 10 | 77473 | 422 | 31619439 |
Myelosuppression | 13.54 | 10.40 | 10 | 77473 | 14910 | 31604951 |
Discomfort | 13.46 | 10.40 | 77 | 77406 | 16279 | 31603582 |
Corneal opacity | 13.45 | 10.40 | 11 | 77472 | 540 | 31619321 |
Xanthelasma | 13.39 | 10.40 | 6 | 77477 | 95 | 31619766 |
Ductus arteriosus stenosis foetal | 13.33 | 10.40 | 6 | 77477 | 96 | 31619765 |
Delirium | 13.32 | 10.40 | 54 | 77429 | 41367 | 31578494 |
Oligohydramnios | 13.32 | 10.40 | 9 | 77474 | 329 | 31619532 |
Intestinal metastasis | 13.30 | 10.40 | 7 | 77476 | 160 | 31619701 |
Neisseria infection | 13.29 | 10.40 | 4 | 77479 | 18 | 31619843 |
Platelet count decreased | 13.26 | 10.40 | 190 | 77293 | 110245 | 31509616 |
Urinary tract infection | 13.24 | 10.40 | 122 | 77361 | 76747 | 31543114 |
Shock symptom | 13.22 | 10.40 | 6 | 77477 | 98 | 31619763 |
Bladder cancer | 13.19 | 10.40 | 10 | 77473 | 14715 | 31605146 |
Duodenal obstruction | 13.18 | 10.40 | 7 | 77476 | 163 | 31619698 |
Fixed eruption | 13.17 | 10.40 | 17 | 77466 | 1436 | 31618425 |
Endoscopy abnormal | 13.12 | 10.40 | 4 | 77479 | 19 | 31619842 |
Central nervous system inflammation | 13.06 | 10.40 | 6 | 77477 | 101 | 31619760 |
Aggression | 13.04 | 10.40 | 47 | 77436 | 37244 | 31582617 |
Megacolon | 13.03 | 10.40 | 18 | 77465 | 1624 | 31618237 |
Lentigo maligna | 13.01 | 10.40 | 9 | 77474 | 342 | 31619519 |
Peritonsillitis | 12.98 | 10.40 | 3 | 77480 | 3 | 31619858 |
Rhabdomyolysis | 12.96 | 10.40 | 223 | 77260 | 63358 | 31556503 |
Laryngeal oedema | 12.96 | 10.40 | 26 | 77457 | 3191 | 31616670 |
Application site exfoliation | 12.95 | 10.40 | 6 | 77477 | 103 | 31619758 |
Stomatitis | 12.95 | 10.40 | 51 | 77432 | 39387 | 31580474 |
Oculomucocutaneous syndrome | 12.92 | 10.40 | 7 | 77476 | 170 | 31619691 |
Dehydration | 12.91 | 10.40 | 209 | 77274 | 118902 | 31500959 |
Drug reaction with eosinophilia and systemic symptoms | 12.91 | 10.40 | 121 | 77362 | 29897 | 31589964 |
Thrombosis mesenteric vessel | 12.87 | 10.40 | 5 | 77478 | 54 | 31619807 |
White blood cell count decreased | 12.87 | 10.40 | 144 | 77339 | 87254 | 31532607 |
Ascites | 12.86 | 10.40 | 54 | 77429 | 40959 | 31578902 |
Keratopathy | 12.81 | 10.40 | 10 | 77473 | 459 | 31619402 |
Ventricular tachycardia | 12.79 | 10.40 | 24 | 77459 | 23677 | 31596184 |
Spondyloarthropathy | 12.76 | 10.40 | 11 | 77472 | 581 | 31619280 |
Skin erosion | 12.75 | 10.40 | 19 | 77464 | 1837 | 31618024 |
Remission not achieved | 12.75 | 10.40 | 6 | 77477 | 107 | 31619754 |
Hyperglycaemia | 12.73 | 10.40 | 46 | 77437 | 36430 | 31583431 |
Gastric bypass | 12.70 | 10.40 | 8 | 77475 | 259 | 31619602 |
Gout | 12.69 | 10.40 | 82 | 77401 | 18092 | 31601769 |
Craniocerebral injury | 12.65 | 10.40 | 24 | 77459 | 2826 | 31617035 |
Oligoarthritis | 12.65 | 10.40 | 6 | 77477 | 109 | 31619752 |
Gouty arthritis | 12.63 | 10.40 | 14 | 77469 | 1008 | 31618853 |
Diarrhoea | 12.62 | 10.40 | 719 | 76764 | 351690 | 31268171 |
Pneumonitis | 12.55 | 10.40 | 36 | 77447 | 30616 | 31589245 |
Hyperaesthesia | 12.55 | 10.40 | 29 | 77454 | 3922 | 31615939 |
Inflammatory marker increased | 12.54 | 10.40 | 30 | 77453 | 4148 | 31615713 |
Eye swelling | 12.52 | 10.40 | 50 | 77433 | 9126 | 31610735 |
Tonsil cancer | 12.51 | 10.40 | 14 | 77469 | 1019 | 31618842 |
Cold sweat | 12.42 | 10.40 | 50 | 77433 | 9159 | 31610702 |
No adverse event | 12.33 | 10.40 | 18 | 77465 | 19607 | 31600254 |
Prurigo | 12.32 | 10.40 | 11 | 77472 | 609 | 31619252 |
Hepatic mass | 12.24 | 10.40 | 14 | 77469 | 1043 | 31618818 |
Linear IgA disease | 12.21 | 10.40 | 17 | 77466 | 1545 | 31618316 |
Double stranded DNA antibody positive | 12.02 | 10.40 | 7 | 77476 | 196 | 31619665 |
Skin graft | 12 | 10.40 | 10 | 77473 | 504 | 31619357 |
Tumour invasion | 11.97 | 10.40 | 8 | 77475 | 287 | 31619574 |
Post infection glomerulonephritis | 11.91 | 10.40 | 5 | 77478 | 67 | 31619794 |
Drug intolerance | 11.90 | 10.40 | 186 | 77297 | 51847 | 31568014 |
Physical examination abnormal | 11.88 | 10.40 | 8 | 77475 | 291 | 31619570 |
Musculoskeletal discomfort | 11.86 | 10.40 | 41 | 77442 | 6982 | 31612879 |
Soft tissue infection | 11.82 | 10.40 | 19 | 77464 | 1962 | 31617899 |
Hyperkalaemia | 11.81 | 10.40 | 222 | 77261 | 64129 | 31555732 |
Dermatosis | 11.78 | 10.40 | 8 | 77475 | 295 | 31619566 |
Unevaluable event | 11.73 | 10.40 | 37 | 77446 | 30538 | 31589323 |
Neutrophil count decreased | 11.69 | 10.40 | 66 | 77417 | 46328 | 31573533 |
Ocular hyperaemia | 11.68 | 10.40 | 52 | 77431 | 9957 | 31609904 |
Intervertebral disc degeneration | 11.66 | 10.40 | 35 | 77448 | 5536 | 31614325 |
Acquired haemophilia | 11.59 | 10.40 | 13 | 77470 | 948 | 31618913 |
Skin necrosis | 11.56 | 10.40 | 35 | 77448 | 5563 | 31614298 |
Myofascial pain syndrome | 11.52 | 10.40 | 8 | 77475 | 306 | 31619555 |
Right ventricular failure | 11.52 | 10.40 | 3 | 77480 | 8279 | 31611582 |
Eye pain | 11.52 | 10.40 | 60 | 77423 | 12244 | 31607617 |
Intestinal transit time decreased | 11.45 | 10.40 | 3 | 77480 | 7 | 31619854 |
Small intestine ulcer | 11.36 | 10.40 | 9 | 77474 | 422 | 31619439 |
Metastases to heart | 11.33 | 10.40 | 6 | 77477 | 139 | 31619722 |
Lipid metabolism disorder | 11.29 | 10.40 | 8 | 77475 | 316 | 31619545 |
COVID-19 | 11.26 | 10.40 | 83 | 77400 | 54738 | 31565123 |
Skin lesion | 11.22 | 10.40 | 84 | 77399 | 19443 | 31600418 |
Duodenitis | 11.17 | 10.40 | 29 | 77454 | 4219 | 31615642 |
Pyoderma gangrenosum | 11.17 | 10.40 | 15 | 77468 | 1317 | 31618544 |
Laboratory test abnormal | 11.11 | 10.40 | 18 | 77465 | 18796 | 31601065 |
Ecthyma | 11.11 | 10.40 | 9 | 77474 | 436 | 31619425 |
Post procedural infection | 11.01 | 10.40 | 30 | 77453 | 4493 | 31615368 |
Terminal insomnia | 11 | 10.40 | 9 | 77474 | 442 | 31619419 |
Ileal perforation | 11.00 | 10.40 | 11 | 77472 | 703 | 31619158 |
Exposure to communicable disease | 10.99 | 10.40 | 6 | 77477 | 148 | 31619713 |
Ulcer | 10.98 | 10.40 | 43 | 77440 | 7778 | 31612083 |
Corneal infiltrates | 10.88 | 10.40 | 6 | 77477 | 151 | 31619710 |
Orthostatic hypotension | 10.88 | 10.40 | 27 | 77456 | 24092 | 31595769 |
Metatarsalgia | 10.84 | 10.40 | 5 | 77478 | 85 | 31619776 |
Adverse event | 10.82 | 10.40 | 15 | 77468 | 16690 | 31603171 |
Ejection fraction | 10.79 | 10.40 | 5 | 77478 | 86 | 31619775 |
Saccadic eye movement | 10.77 | 10.40 | 6 | 77477 | 154 | 31619707 |
Skull fractured base | 10.77 | 10.40 | 6 | 77477 | 154 | 31619707 |
Hypertension | 10.72 | 10.40 | 235 | 77248 | 127865 | 31491996 |
Postictal paralysis | 10.71 | 10.40 | 7 | 77476 | 242 | 31619619 |
Duodenal ulcer repair | 10.68 | 10.40 | 3 | 77480 | 10 | 31619851 |
Pancreatitis | 10.66 | 10.40 | 48 | 77435 | 35723 | 31584138 |
Obstruction gastric | 10.65 | 10.40 | 12 | 77471 | 880 | 31618981 |
Rash | 10.64 | 10.40 | 598 | 76885 | 200888 | 31418973 |
Slow speech | 10.62 | 10.40 | 13 | 77470 | 1041 | 31618820 |
Febrile bone marrow aplasia | 10.62 | 10.40 | 3 | 77480 | 7843 | 31612018 |
Sudden cardiac death | 10.61 | 10.40 | 25 | 77458 | 3424 | 31616437 |
Application site dermatitis | 10.57 | 10.40 | 4 | 77479 | 40 | 31619821 |
Oral herpes | 10.56 | 10.40 | 31 | 77452 | 4842 | 31615019 |
Brain natriuretic peptide increased | 10.55 | 10.40 | 31 | 77452 | 4845 | 31615016 |
Small intestine carcinoma | 10.55 | 10.40 | 10 | 77473 | 598 | 31619263 |
Burns second degree | 10.46 | 10.40 | 8 | 77475 | 356 | 31619505 |
Axillary pain | 10.46 | 10.40 | 8 | 77475 | 356 | 31619505 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pemphigus | 1487.74 | 9.98 | 1655 | 252207 | 81381 | 70593201 |
Systemic lupus erythematosus | 1330.01 | 9.98 | 1729 | 252133 | 100173 | 70574409 |
Glossodynia | 1293.55 | 9.98 | 1571 | 252291 | 84916 | 70589666 |
Hand deformity | 1266.02 | 9.98 | 1554 | 252308 | 84928 | 70589654 |
Pericarditis | 1243.07 | 9.98 | 1524 | 252338 | 83181 | 70591401 |
Anti-cyclic citrullinated peptide antibody positive | 1140.18 | 9.98 | 1330 | 252532 | 68855 | 70605727 |
Wound | 1090.44 | 9.98 | 1545 | 252317 | 97187 | 70577395 |
Discomfort | 1035.54 | 9.98 | 1561 | 252301 | 103875 | 70570707 |
Duodenal ulcer perforation | 963.95 | 9.98 | 1047 | 252815 | 50065 | 70624517 |
Embolia cutis medicamentosa | 936.32 | 9.98 | 245 | 253617 | 311 | 70674271 |
Arthropathy | 888.18 | 9.98 | 1776 | 252086 | 148281 | 70526301 |
Synovitis | 842.08 | 9.98 | 1593 | 252269 | 127635 | 70546947 |
Helicobacter infection | 825.25 | 9.98 | 1007 | 252855 | 54649 | 70619933 |
Abdominal discomfort | 807.80 | 9.98 | 2124 | 251738 | 212534 | 70462048 |
Swelling | 771.85 | 9.98 | 1926 | 251936 | 186613 | 70487969 |
Alopecia | 755.90 | 9.98 | 1973 | 251889 | 196517 | 70478065 |
Joint swelling | 647.38 | 9.98 | 2185 | 251677 | 251026 | 70423556 |
Rheumatoid arthritis | 621.61 | 9.98 | 2372 | 251490 | 289433 | 70385149 |
Death | 604.62 | 9.98 | 562 | 253300 | 509499 | 70165083 |
Hepatic enzyme increased | 604.03 | 9.98 | 1567 | 252295 | 155423 | 70519159 |
Hypersensitivity | 578.38 | 9.98 | 1973 | 251889 | 227839 | 70446743 |
Contraindicated product administered | 576.86 | 9.98 | 1400 | 252462 | 133212 | 70541370 |
Maternal exposure during pregnancy | 556.83 | 9.98 | 1257 | 252605 | 114088 | 70560494 |
Blister | 555.48 | 9.98 | 1157 | 252705 | 99369 | 70575213 |
Muscle injury | 520.14 | 9.98 | 665 | 253197 | 37829 | 70636753 |
Rheumatoid factor positive | 518.58 | 9.98 | 747 | 253115 | 47653 | 70626929 |
Drug intolerance | 499.64 | 9.98 | 1858 | 252004 | 223829 | 70450753 |
Irritable bowel syndrome | 490.44 | 9.98 | 747 | 253115 | 50103 | 70624479 |
Folliculitis | 485.59 | 9.98 | 677 | 253185 | 41893 | 70632689 |
Infusion related reaction | 458.84 | 9.98 | 1652 | 252210 | 195882 | 70478700 |
Sleep disorder due to general medical condition, insomnia type | 437.34 | 9.98 | 588 | 253274 | 35144 | 70639438 |
Pain | 403.27 | 9.98 | 3718 | 250144 | 625098 | 70049484 |
Therapeutic product effect decreased | 395.22 | 9.98 | 1268 | 252594 | 141750 | 70532832 |
Febrile neutropenia | 374.01 | 9.98 | 132 | 253730 | 204186 | 70470396 |
Impaired healing | 344.86 | 9.98 | 798 | 253064 | 73576 | 70601006 |
Neutropenia | 335.13 | 9.98 | 258 | 253604 | 256898 | 70417684 |
Gastrointestinal disorder | 307.92 | 9.98 | 953 | 252909 | 104474 | 70570108 |
Musculoskeletal stiffness | 273.72 | 9.98 | 1151 | 252711 | 146609 | 70527973 |
Toxicity to various agents | 258.36 | 9.98 | 620 | 253242 | 381552 | 70293030 |
Rheumatic fever | 252.66 | 9.98 | 314 | 253548 | 17346 | 70657236 |
Ankylosing spondylitis | 248.62 | 9.98 | 255 | 253607 | 11391 | 70663191 |
Completed suicide | 241.53 | 9.98 | 274 | 253588 | 226861 | 70447721 |
Pneumonia | 236.32 | 9.98 | 1215 | 252647 | 595017 | 70079565 |
Arthralgia | 234.62 | 9.98 | 2792 | 251070 | 500598 | 70173984 |
Melaena | 233.55 | 9.98 | 579 | 253283 | 55776 | 70618806 |
Gastric ulcer | 233.39 | 9.98 | 413 | 253449 | 31377 | 70643205 |
Off label use | 222.44 | 9.98 | 1653 | 252209 | 741407 | 69933175 |
Hip arthroplasty | 221.14 | 9.98 | 376 | 253486 | 27664 | 70646918 |
Swollen joint count increased | 211.26 | 9.98 | 253 | 253609 | 13447 | 70661135 |
Thrombocytopenia | 193.37 | 9.98 | 350 | 253512 | 238760 | 70435822 |
Treatment failure | 193.05 | 9.98 | 1022 | 252840 | 143120 | 70531462 |
Product use issue | 189.58 | 9.98 | 1197 | 252665 | 178740 | 70495842 |
Psoriatic arthropathy | 186.72 | 9.98 | 583 | 253279 | 64188 | 70610394 |
Rash | 185.26 | 9.98 | 2706 | 251156 | 507856 | 70166726 |
Hypotension | 182.33 | 9.98 | 786 | 253076 | 403595 | 70270987 |
Cardiac failure congestive | 176.19 | 9.98 | 136 | 253726 | 135321 | 70539261 |
Knee arthroplasty | 175.66 | 9.98 | 383 | 253479 | 33918 | 70640664 |
Disease progression | 175.36 | 9.98 | 181 | 253681 | 156491 | 70518091 |
Atrial fibrillation | 173.42 | 9.98 | 244 | 253618 | 184104 | 70490478 |
Lower respiratory tract infection | 165.54 | 9.98 | 816 | 253046 | 111097 | 70563485 |
Ill-defined disorder | 165.48 | 9.98 | 501 | 253361 | 54240 | 70620342 |
Stomatitis | 157.80 | 9.98 | 890 | 252972 | 127621 | 70546961 |
Duodenal ulcer | 155.13 | 9.98 | 230 | 253632 | 15050 | 70659532 |
Plasma cell myeloma | 152.67 | 9.98 | 37 | 253825 | 73164 | 70601418 |
Sepsis | 151.74 | 9.98 | 414 | 253448 | 244131 | 70430451 |
Large intestinal stenosis | 138.60 | 9.98 | 96 | 253766 | 2467 | 70672115 |
Gastric ulcer perforation | 137.19 | 9.98 | 87 | 253775 | 1920 | 70672662 |
Blood cholesterol increased | 136.08 | 9.98 | 524 | 253338 | 64080 | 70610502 |
Grip strength decreased | 133.95 | 9.98 | 218 | 253644 | 15467 | 70659115 |
Pancytopenia | 133.34 | 9.98 | 209 | 253653 | 150898 | 70523684 |
Cough | 132.57 | 9.98 | 656 | 253206 | 324721 | 70349861 |
Diarrhoea | 129.39 | 9.98 | 2000 | 251862 | 781341 | 69893241 |
Type 2 diabetes mellitus | 126.31 | 9.98 | 396 | 253466 | 43684 | 70630898 |
Anaphylactic shock | 124.37 | 9.98 | 324 | 253538 | 32166 | 70642416 |
Electrocardiogram QT prolonged | 123.11 | 9.98 | 73 | 253789 | 83444 | 70591138 |
Intestinal diaphragm disease | 121.01 | 9.98 | 46 | 253816 | 304 | 70674278 |
Osteoarthritis | 118.55 | 9.98 | 553 | 253309 | 73594 | 70600988 |
Product dose omission issue | 117.76 | 9.98 | 392 | 253470 | 217076 | 70457506 |
Pruritus | 117.08 | 9.98 | 1811 | 252051 | 343749 | 70330833 |
Fibromyalgia | 111.41 | 9.98 | 401 | 253461 | 47473 | 70627109 |
Large intestinal ulcer | 109.73 | 9.98 | 105 | 253757 | 4307 | 70670275 |
Angioedema | 109.60 | 9.98 | 501 | 253361 | 66109 | 70608473 |
Seizure | 106.10 | 9.98 | 307 | 253555 | 177655 | 70496927 |
Contusion | 105.35 | 9.98 | 802 | 253060 | 127234 | 70547348 |
Platelet count decreased | 105.13 | 9.98 | 309 | 253553 | 177913 | 70496669 |
Constipation | 101.02 | 9.98 | 512 | 253350 | 251926 | 70422656 |
Cerebrovascular accident | 100.55 | 9.98 | 228 | 253634 | 143242 | 70531340 |
Gastritis erosive | 95.44 | 9.98 | 147 | 253715 | 9948 | 70664634 |
Dehydration | 94.31 | 9.98 | 452 | 253410 | 225690 | 70448892 |
Nasopharyngitis | 94.27 | 9.98 | 1212 | 252650 | 220994 | 70453588 |
Hypokalaemia | 93.14 | 9.98 | 207 | 253655 | 130981 | 70543601 |
Leukopenia | 91.52 | 9.98 | 150 | 253712 | 106410 | 70568172 |
Cardiac arrest | 91.47 | 9.98 | 281 | 253581 | 159553 | 70515029 |
Peripheral swelling | 91.14 | 9.98 | 1268 | 252594 | 235295 | 70439287 |
Kounis syndrome | 90.23 | 9.98 | 84 | 253778 | 3327 | 70671255 |
Anaphylactic reaction | 86.60 | 9.98 | 511 | 253351 | 74463 | 70600119 |
White blood cell count decreased | 86.49 | 9.98 | 315 | 253547 | 169826 | 70504756 |
Cardio-respiratory arrest | 86.20 | 9.98 | 142 | 253720 | 100535 | 70574047 |
Sinusitis | 85.85 | 9.98 | 955 | 252907 | 168240 | 70506342 |
Infection | 83.69 | 9.98 | 1136 | 252726 | 209649 | 70464933 |
Hypoxia | 81.47 | 9.98 | 130 | 253732 | 93214 | 70581368 |
Neutrophil count decreased | 81.13 | 9.98 | 108 | 253754 | 83448 | 70591134 |
Deafness transitory | 79.93 | 9.98 | 47 | 253815 | 901 | 70673681 |
Respiratory failure | 79.58 | 9.98 | 322 | 253540 | 168413 | 70506169 |
Malignant neoplasm progression | 79.32 | 9.98 | 201 | 253661 | 121538 | 70553044 |
Cytomegalovirus infection | 79.26 | 9.98 | 22 | 253840 | 39736 | 70634846 |
Bradycardia | 78.70 | 9.98 | 209 | 253653 | 124406 | 70550176 |
Hypoglycaemia | 76.31 | 9.98 | 138 | 253724 | 94226 | 70580356 |
Liver injury | 76.14 | 9.98 | 320 | 253542 | 40715 | 70633867 |
Fall | 75.39 | 9.98 | 1127 | 252735 | 442969 | 70231613 |
Cardiac failure | 74.11 | 9.98 | 264 | 253598 | 143277 | 70531305 |
Periorbital oedema | 73.20 | 9.98 | 113 | 253749 | 7662 | 70666920 |
Nausea | 70.34 | 9.98 | 2422 | 251440 | 849666 | 69824916 |
Neuropathy peripheral | 69.85 | 9.98 | 227 | 253635 | 126669 | 70547913 |
Pulmonary embolism | 69.44 | 9.98 | 304 | 253558 | 155563 | 70519019 |
Drug abuse | 69.44 | 9.98 | 281 | 253581 | 146975 | 70527607 |
Anxiety | 68.99 | 9.98 | 483 | 253379 | 219847 | 70454735 |
Sacroiliitis | 68.65 | 9.98 | 71 | 253791 | 3202 | 70671380 |
Cognitive disorder | 68.64 | 9.98 | 70 | 253792 | 60886 | 70613696 |
Joint dislocation | 68.49 | 9.98 | 157 | 253705 | 14374 | 70660208 |
Hospitalisation | 66.53 | 9.98 | 121 | 253741 | 82447 | 70592135 |
COVID-19 | 66.30 | 9.98 | 178 | 253684 | 105579 | 70569003 |
Mental status changes | 66.03 | 9.98 | 77 | 253785 | 63024 | 70611558 |
Hypomagnesaemia | 65.38 | 9.98 | 32 | 253830 | 40732 | 70633850 |
Myocardial infarction | 63.14 | 9.98 | 358 | 253504 | 171287 | 70503295 |
Gastric ulcer haemorrhage | 62.94 | 9.98 | 111 | 253751 | 8407 | 70666175 |
Pleural effusion | 62.35 | 9.98 | 254 | 253608 | 132610 | 70541972 |
Injection site necrosis | 62.22 | 9.98 | 46 | 253816 | 1313 | 70673269 |
Urinary tract infection | 61.97 | 9.98 | 580 | 253282 | 248189 | 70426393 |
Type I hypersensitivity | 60.98 | 9.98 | 71 | 253791 | 3661 | 70670921 |
Aspirin-exacerbated respiratory disease | 59.88 | 9.98 | 43 | 253819 | 1172 | 70673410 |
Oxygen saturation decreased | 59.52 | 9.98 | 215 | 253647 | 116214 | 70558368 |
Ascites | 59.01 | 9.98 | 94 | 253768 | 67453 | 70607129 |
Ear infection | 58.96 | 9.98 | 229 | 253633 | 28107 | 70646475 |
Pulmonary arterial hypertension | 58.73 | 9.98 | 22 | 253840 | 32833 | 70641749 |
Neurotoxicity | 58.53 | 9.98 | 17 | 253845 | 29809 | 70644773 |
Device expulsion | 58.12 | 9.98 | 6 | 253856 | 22240 | 70652342 |
Abdominal pain upper | 58.12 | 9.98 | 995 | 252867 | 192607 | 70481975 |
Cytokine release syndrome | 57.95 | 9.98 | 12 | 253850 | 26455 | 70648127 |
Maternal exposure timing unspecified | 57.93 | 9.98 | 75 | 253787 | 4316 | 70670266 |
General physical health deterioration | 57.68 | 9.98 | 1175 | 252687 | 234856 | 70439726 |
Urticaria | 57.59 | 9.98 | 861 | 253001 | 162188 | 70512394 |
Live birth | 57.51 | 9.98 | 142 | 253720 | 13637 | 70660945 |
Neuroleptic malignant syndrome | 56.51 | 9.98 | 12 | 253850 | 25995 | 70648587 |
Retinitis | 56.37 | 9.98 | 72 | 253790 | 4088 | 70670494 |
Adverse event | 55.75 | 9.98 | 335 | 253527 | 49126 | 70625456 |
Epistaxis | 54.81 | 9.98 | 186 | 253676 | 102441 | 70572141 |
Gastrointestinal erosion | 54.57 | 9.98 | 38 | 253824 | 985 | 70673597 |
Tachycardia | 54.44 | 9.98 | 338 | 253524 | 158208 | 70516374 |
Acute myeloid leukaemia | 53.20 | 9.98 | 22 | 253840 | 30918 | 70643664 |
Mucosal inflammation | 51.54 | 9.98 | 103 | 253759 | 67747 | 70606835 |
Seronegative arthritis | 51.43 | 9.98 | 62 | 253800 | 3317 | 70671265 |
Deep vein thrombosis | 50.41 | 9.98 | 215 | 253647 | 110827 | 70563755 |
Spinal pain | 50.33 | 9.98 | 135 | 253727 | 13635 | 70660947 |
Bacteraemia | 50.14 | 9.98 | 21 | 253841 | 29288 | 70645294 |
Agitation | 50.02 | 9.98 | 169 | 253693 | 93206 | 70581376 |
Neoplasm progression | 49.72 | 9.98 | 53 | 253809 | 45175 | 70629407 |
Red blood cell sedimentation rate abnormal | 48.43 | 9.98 | 6 | 253856 | 19297 | 70655285 |
Septic shock | 48.15 | 9.98 | 222 | 253640 | 112036 | 70562546 |
Clostridium difficile infection | 47.91 | 9.98 | 41 | 253821 | 38775 | 70635807 |
Posterior reversible encephalopathy syndrome | 47.72 | 9.98 | 14 | 253848 | 24388 | 70650194 |
Fluid retention | 47.48 | 9.98 | 97 | 253765 | 63288 | 70611294 |
Dislocation of vertebra | 47.23 | 9.98 | 72 | 253790 | 4828 | 70669754 |
Blood glucose increased | 46.99 | 9.98 | 199 | 253663 | 102783 | 70571799 |
Facet joint syndrome | 46.91 | 9.98 | 81 | 253781 | 6032 | 70668550 |
Encephalopathy | 46.50 | 9.98 | 94 | 253768 | 61567 | 70613015 |
Joint range of motion decreased | 45.99 | 9.98 | 200 | 253662 | 25826 | 70648756 |
Gastric haemorrhage | 45.87 | 9.98 | 133 | 253729 | 14052 | 70660530 |
Oligohydramnios | 45.37 | 9.98 | 57 | 253805 | 3183 | 70671399 |
Anti-cyclic citrullinated peptide antibody | 44.95 | 9.98 | 58 | 253804 | 3327 | 70671255 |
Adjustment disorder with depressed mood | 44.94 | 9.98 | 65 | 253797 | 4158 | 70670424 |
Myelosuppression | 44.91 | 9.98 | 26 | 253836 | 30119 | 70644463 |
Transplant rejection | 44.74 | 9.98 | 6 | 253856 | 18165 | 70656417 |
Corneal epithelium defect | 44.68 | 9.98 | 29 | 253833 | 667 | 70673915 |
Aggression | 44.64 | 9.98 | 65 | 253797 | 48381 | 70626201 |
Balance disorder | 44.38 | 9.98 | 169 | 253693 | 89959 | 70584623 |
Pancreatitis | 44.36 | 9.98 | 99 | 253763 | 62569 | 70612013 |
Haematemesis | 44.30 | 9.98 | 313 | 253549 | 48484 | 70626098 |
Hyperglycaemia | 44.30 | 9.98 | 104 | 253758 | 64568 | 70610014 |
Hypervolaemia | 44.24 | 9.98 | 46 | 253816 | 39660 | 70634922 |
Chronic obstructive pulmonary disease | 44.04 | 9.98 | 137 | 253725 | 77504 | 70597078 |
Bone marrow failure | 43.95 | 9.98 | 67 | 253795 | 48943 | 70625639 |
Injury | 43.59 | 9.98 | 390 | 253472 | 64855 | 70609727 |
Anaemia | 43.27 | 9.98 | 1106 | 252756 | 402317 | 70272265 |
Ventricular tachycardia | 43.12 | 9.98 | 40 | 253822 | 36383 | 70638199 |
Asthenia | 43.09 | 9.98 | 1278 | 252584 | 456388 | 70218194 |
Drug resistance | 42.83 | 9.98 | 44 | 253818 | 38146 | 70636436 |
Diabetes mellitus | 42.70 | 9.98 | 124 | 253738 | 71700 | 70602882 |
Schizophrenia | 42.60 | 9.98 | 5 | 253857 | 16763 | 70657819 |
Small intestine ulcer | 42.28 | 9.98 | 28 | 253834 | 667 | 70673915 |
Endoscopy abnormal | 42.15 | 9.98 | 13 | 253849 | 40 | 70674542 |
Mobility decreased | 42.02 | 9.98 | 558 | 253304 | 102441 | 70572141 |
Thrombotic microangiopathy | 41.41 | 9.98 | 7 | 253855 | 17841 | 70656741 |
Spinal stenosis | 41.38 | 9.98 | 131 | 253731 | 14522 | 70660060 |
Shoulder arthroplasty | 41.23 | 9.98 | 52 | 253810 | 2915 | 70671667 |
Drug ineffective | 40.66 | 9.98 | 3896 | 249966 | 935856 | 69738726 |
Fat necrosis | 40.52 | 9.98 | 29 | 253833 | 786 | 70673796 |
Intestinal ulcer | 40.43 | 9.98 | 40 | 253822 | 1710 | 70672872 |
Lip dry | 39.95 | 9.98 | 100 | 253762 | 9685 | 70664897 |
Hypercalcaemia | 39.26 | 9.98 | 39 | 253823 | 34346 | 70640236 |
Deep vein thrombosis postoperative | 39.09 | 9.98 | 56 | 253806 | 3551 | 70671031 |
Respiratory distress | 38.96 | 9.98 | 86 | 253776 | 54564 | 70620018 |
Ileal ulcer | 38.67 | 9.98 | 31 | 253831 | 1000 | 70673582 |
Pericardial effusion | 38.54 | 9.98 | 56 | 253806 | 41720 | 70632862 |
Tonsillar ulcer | 38.11 | 9.98 | 22 | 253840 | 407 | 70674175 |
Ulcerative keratitis | 38.05 | 9.98 | 53 | 253809 | 3274 | 70671308 |
Right ventricular failure | 38.03 | 9.98 | 16 | 253846 | 22258 | 70652324 |
Upper gastrointestinal haemorrhage | 37.96 | 9.98 | 247 | 253615 | 37230 | 70637352 |
Prescribed overdose | 37.90 | 9.98 | 195 | 253667 | 26986 | 70647596 |
Tubulointerstitial nephritis | 37.90 | 9.98 | 225 | 253637 | 32851 | 70641731 |
Haematotoxicity | 37.57 | 9.98 | 3 | 253859 | 13671 | 70660911 |
Pneumonia aspiration | 37.42 | 9.98 | 107 | 253755 | 62182 | 70612400 |
Hypoaesthesia | 37.41 | 9.98 | 765 | 253097 | 152974 | 70521608 |
Ejection fraction decreased | 37.35 | 9.98 | 33 | 253829 | 30729 | 70643853 |
Sleep disorder | 37.06 | 9.98 | 398 | 253464 | 69474 | 70605108 |
Unevaluable event | 37.05 | 9.98 | 82 | 253780 | 51981 | 70622601 |
Duodenal ulcer haemorrhage | 36.67 | 9.98 | 77 | 253785 | 6641 | 70667941 |
Torsade de pointes | 36.15 | 9.98 | 10 | 253852 | 18106 | 70656476 |
Functional gastrointestinal disorder | 36.04 | 9.98 | 61 | 253801 | 4470 | 70670112 |
Gastrointestinal pain | 36.01 | 9.98 | 87 | 253775 | 8240 | 70666342 |
Bronchopulmonary aspergillosis | 36.00 | 9.98 | 15 | 253847 | 20987 | 70653595 |
Full blood count abnormal | 35.81 | 9.98 | 41 | 253821 | 33837 | 70640745 |
Cytopenia | 35.64 | 9.98 | 9 | 253853 | 17314 | 70657268 |
Orthostatic hypotension | 35.60 | 9.98 | 83 | 253779 | 51660 | 70622922 |
Peptic ulcer | 35.37 | 9.98 | 69 | 253793 | 5644 | 70668938 |
Laryngitis | 35.02 | 9.98 | 118 | 253744 | 13513 | 70661069 |
Weight increased | 34.83 | 9.98 | 1124 | 252738 | 241207 | 70433375 |
Porphyria acute | 34.80 | 9.98 | 32 | 253830 | 1247 | 70673335 |
Mucosal erosion | 34.56 | 9.98 | 40 | 253822 | 2049 | 70672533 |
Exposure during pregnancy | 34.46 | 9.98 | 472 | 253390 | 87245 | 70587337 |
Multiple organ dysfunction syndrome | 34.37 | 9.98 | 237 | 253625 | 108278 | 70566304 |
Hypocalcaemia | 34.15 | 9.98 | 68 | 253794 | 44791 | 70629791 |
Application site rash | 34.13 | 9.98 | 39 | 253823 | 1970 | 70672612 |
Keratopathy | 33.92 | 9.98 | 28 | 253834 | 942 | 70673640 |
Wrong technique in product usage process | 33.70 | 9.98 | 129 | 253733 | 68569 | 70606013 |
Analgesic drug level above therapeutic | 33.53 | 9.98 | 21 | 253841 | 453 | 70674129 |
Neutropenic sepsis | 33.46 | 9.98 | 24 | 253838 | 24806 | 70649776 |
Peritonitis | 33.28 | 9.98 | 183 | 253679 | 25976 | 70648606 |
Hallucination | 33.18 | 9.98 | 150 | 253712 | 76110 | 70598472 |
Dyspnoea exertional | 33.10 | 9.98 | 156 | 253706 | 78274 | 70596308 |
Heart rate increased | 33.04 | 9.98 | 233 | 253629 | 105915 | 70568667 |
Depression | 32.97 | 9.98 | 507 | 253355 | 198467 | 70476115 |
Ligament calcification | 32.90 | 9.98 | 16 | 253846 | 205 | 70674377 |
Large intestine perforation | 32.82 | 9.98 | 113 | 253749 | 13082 | 70661500 |
Renal failure neonatal | 32.68 | 9.98 | 12 | 253850 | 71 | 70674511 |
Ductus arteriosus stenosis foetal | 32.68 | 9.98 | 12 | 253850 | 71 | 70674511 |
Status epilepticus | 32.67 | 9.98 | 24 | 253838 | 24502 | 70650080 |
Progressive multifocal leukoencephalopathy | 32.49 | 9.98 | 14 | 253848 | 19200 | 70655382 |
Febrile bone marrow aplasia | 31.94 | 9.98 | 3 | 253859 | 11988 | 70662594 |
Aspergillus infection | 31.88 | 9.98 | 12 | 253850 | 17856 | 70656726 |
Device related infection | 31.85 | 9.98 | 41 | 253821 | 32144 | 70642438 |
Transfusion | 31.42 | 9.98 | 14 | 253848 | 18822 | 70655760 |
Neck pain | 31.41 | 9.98 | 371 | 253491 | 66286 | 70608296 |
Diabetic ketoacidosis | 31.33 | 9.98 | 40 | 253822 | 31472 | 70643110 |
Inflammatory bowel disease | 31.31 | 9.98 | 61 | 253801 | 4985 | 70669597 |
Cardiogenic shock | 31.26 | 9.98 | 51 | 253811 | 36256 | 70638326 |
Enterococcal infection | 31.13 | 9.98 | 7 | 253855 | 14575 | 70660007 |
Atelectasis | 30.67 | 9.98 | 35 | 253827 | 28927 | 70645655 |
Lymphocyte count decreased | 30.63 | 9.98 | 69 | 253793 | 43470 | 70631112 |
Pharyngitis | 30.49 | 9.98 | 149 | 253713 | 20202 | 70654380 |
Dyspnoea | 30.25 | 9.98 | 2360 | 251502 | 767700 | 69906882 |
Generalised tonic-clonic seizure | 30.16 | 9.98 | 65 | 253797 | 41596 | 70632986 |
Bladder cancer | 30.07 | 9.98 | 12 | 253850 | 17230 | 70657352 |
Incorrect dose administered | 29.77 | 9.98 | 130 | 253732 | 66589 | 70607993 |
Sedation complication | 29.52 | 9.98 | 6 | 253856 | 13404 | 70661178 |
Corneal thinning | 29.45 | 9.98 | 14 | 253848 | 170 | 70674412 |
Cellulitis | 29.42 | 9.98 | 220 | 253642 | 98708 | 70575874 |
Respiratory arrest | 29.30 | 9.98 | 97 | 253765 | 53836 | 70620746 |
Coma | 28.88 | 9.98 | 201 | 253661 | 91643 | 70582939 |
Lymphocyte stimulation test positive | 28.78 | 9.98 | 27 | 253835 | 1080 | 70673502 |
Device dislocation | 28.73 | 9.98 | 23 | 253839 | 22484 | 70652098 |
Application site eczema | 28.70 | 9.98 | 7 | 253855 | 5 | 70674577 |
Gastrointestinal ulcer | 28.62 | 9.98 | 45 | 253817 | 3100 | 70671482 |
Hyponatraemia | 28.57 | 9.98 | 402 | 253460 | 159685 | 70514897 |
Syncope | 28.56 | 9.98 | 419 | 253443 | 165290 | 70509292 |
Conjunctival hyperaemia | 28.53 | 9.98 | 52 | 253810 | 4041 | 70670541 |
Pulmonary oedema | 28.44 | 9.98 | 175 | 253687 | 82103 | 70592479 |
Exostosis | 28.29 | 9.98 | 114 | 253748 | 14231 | 70660351 |
Obstructive airways disorder | 28.26 | 9.98 | 31 | 253831 | 26082 | 70648500 |
Immune reconstitution inflammatory syndrome | 28.21 | 9.98 | 6 | 253856 | 12984 | 70661598 |
Dry skin | 28.10 | 9.98 | 104 | 253758 | 55827 | 70618755 |
Tenderness | 28.08 | 9.98 | 150 | 253712 | 21060 | 70653522 |
Intestinal atony | 27.98 | 9.98 | 9 | 253853 | 33 | 70674549 |
Psychotic disorder | 27.98 | 9.98 | 58 | 253804 | 37643 | 70636939 |
Neonatal respiratory acidosis | 27.84 | 9.98 | 10 | 253852 | 55 | 70674527 |
Hepatic failure | 27.75 | 9.98 | 109 | 253753 | 57516 | 70617066 |
Infective pulmonary exacerbation of cystic fibrosis | 27.70 | 9.98 | 5 | 253857 | 12153 | 70662429 |
Hypernatraemia | 27.50 | 9.98 | 6 | 253856 | 12755 | 70661827 |
Synovial cyst | 27.34 | 9.98 | 81 | 253781 | 8661 | 70665921 |
Foot deformity | 27.29 | 9.98 | 146 | 253716 | 20509 | 70654073 |
Pneumocystis jirovecii pneumonia | 27.09 | 9.98 | 41 | 253821 | 30041 | 70644541 |
Gastritis | 27.00 | 9.98 | 261 | 253601 | 44330 | 70630252 |
Adverse drug reaction | 26.97 | 9.98 | 301 | 253561 | 53043 | 70621539 |
Glomerulonephritis minimal lesion | 26.96 | 9.98 | 22 | 253840 | 728 | 70673854 |
Soft tissue injury | 26.87 | 9.98 | 32 | 253830 | 1690 | 70672892 |
Diabetes mellitus inadequate control | 26.65 | 9.98 | 25 | 253837 | 22620 | 70651962 |
C-reactive protein increased | 26.57 | 9.98 | 549 | 253313 | 109968 | 70564614 |
Dysphagia | 26.40 | 9.98 | 267 | 253595 | 112567 | 70562015 |
Rotator cuff repair | 26.29 | 9.98 | 31 | 253831 | 1620 | 70672962 |
Akathisia | 26.05 | 9.98 | 6 | 253856 | 12287 | 70662295 |
Chest discomfort | 26.03 | 9.98 | 302 | 253560 | 124079 | 70550503 |
Drug hypersensitivity | 25.91 | 9.98 | 1168 | 252694 | 261291 | 70413291 |
Weight decreased | 25.81 | 9.98 | 881 | 252981 | 309607 | 70364975 |
Lymphatic fistula | 25.72 | 9.98 | 22 | 253840 | 778 | 70673804 |
Femoral hernia incarcerated | 25.56 | 9.98 | 22 | 253840 | 785 | 70673797 |
Pregnancy | 25.49 | 9.98 | 159 | 253703 | 23622 | 70650960 |
Mastoid abscess | 25.40 | 9.98 | 6 | 253856 | 3 | 70674579 |
Bradycardia neonatal | 25.35 | 9.98 | 10 | 253852 | 74 | 70674508 |
Urosepsis | 25.29 | 9.98 | 29 | 253833 | 23920 | 70650662 |
Jejunal ulcer perforation | 25.28 | 9.98 | 11 | 253851 | 107 | 70674475 |
Multiple sclerosis relapse | 25.03 | 9.98 | 75 | 253787 | 42942 | 70631640 |
Metastases to stomach | 24.99 | 9.98 | 14 | 253848 | 244 | 70674338 |
Tissue infiltration | 24.98 | 9.98 | 20 | 253842 | 644 | 70673938 |
Inflammation | 24.93 | 9.98 | 408 | 253454 | 78257 | 70596325 |
Lymphopenia | 24.92 | 9.98 | 37 | 253825 | 27322 | 70647260 |
Iris hypopigmentation | 24.69 | 9.98 | 9 | 253853 | 52 | 70674530 |
Second primary malignancy | 24.60 | 9.98 | 8 | 253854 | 13043 | 70661539 |
Cardiac disorder | 24.59 | 9.98 | 119 | 253743 | 59296 | 70615286 |
Cyanosis neonatal | 24.55 | 9.98 | 9 | 253853 | 53 | 70674529 |
Device issue | 24.40 | 9.98 | 30 | 253832 | 23995 | 70650587 |
Staphylococcal bacteraemia | 24.31 | 9.98 | 5 | 253857 | 11077 | 70663505 |
Myocarditis | 24.25 | 9.98 | 19 | 253843 | 18774 | 70655808 |
Necrotising fasciitis | 24.18 | 9.98 | 58 | 253804 | 5468 | 70669114 |
Microcytic anaemia | 23.97 | 9.98 | 53 | 253809 | 4736 | 70669846 |
Unresponsive to stimuli | 23.90 | 9.98 | 100 | 253762 | 51831 | 70622751 |
Antidepressant drug level above therapeutic | 23.83 | 9.98 | 19 | 253843 | 608 | 70673974 |
Frequent bowel movements | 23.01 | 9.98 | 25 | 253837 | 21128 | 70653454 |
Paranoia | 22.92 | 9.98 | 17 | 253845 | 17271 | 70657311 |
Palmar-plantar erythrodysaesthesia syndrome | 22.90 | 9.98 | 46 | 253816 | 30201 | 70644381 |
Abnormal behaviour | 22.83 | 9.98 | 57 | 253805 | 34652 | 70639930 |
Peripheral venous disease | 22.75 | 9.98 | 87 | 253775 | 10600 | 70663982 |
Confusional state | 22.74 | 9.98 | 1240 | 252622 | 283158 | 70391424 |
Suicidal ideation | 22.53 | 9.98 | 151 | 253711 | 69445 | 70605137 |
Tongue oedema | 22.51 | 9.98 | 61 | 253801 | 6198 | 70668384 |
Pulmonary hypertension | 22.43 | 9.98 | 88 | 253774 | 46448 | 70628134 |
Dysarthria | 22.34 | 9.98 | 131 | 253731 | 62182 | 70612400 |
Lupus-like syndrome | 22.30 | 9.98 | 91 | 253771 | 11424 | 70663158 |
Premature delivery | 22.28 | 9.98 | 26 | 253836 | 21278 | 70653304 |
Orbital oedema | 22.27 | 9.98 | 14 | 253848 | 304 | 70674278 |
Extrapyramidal disorder | 22.05 | 9.98 | 25 | 253837 | 20725 | 70653857 |
Blood pressure increased | 22.03 | 9.98 | 510 | 253352 | 188007 | 70486575 |
Tubulointerstitial nephritis and uveitis syndrome | 21.99 | 9.98 | 14 | 253848 | 311 | 70674271 |
Renal failure | 21.96 | 9.98 | 512 | 253350 | 188558 | 70486024 |
Haemoptysis | 21.91 | 9.98 | 102 | 253760 | 51350 | 70623232 |
Wrist deformity | 21.80 | 9.98 | 30 | 253832 | 1832 | 70672750 |
Muscle swelling | 21.70 | 9.98 | 20 | 253842 | 782 | 70673800 |
Arteriovenous fistula occlusion | 21.65 | 9.98 | 17 | 253845 | 532 | 70674050 |
Acute graft versus host disease | 21.64 | 9.98 | 4 | 253858 | 9558 | 70665024 |
Fatigue | 21.57 | 9.98 | 3312 | 250550 | 821007 | 69853575 |
Failure to thrive | 21.57 | 9.98 | 6 | 253856 | 10823 | 70663759 |
Anterior chamber cell | 21.49 | 9.98 | 21 | 253841 | 884 | 70673698 |
Application site reaction | 21.47 | 9.98 | 19 | 253843 | 704 | 70673878 |
Complication associated with device | 21.42 | 9.98 | 15 | 253847 | 15698 | 70658884 |
Acute respiratory failure | 21.34 | 9.98 | 109 | 253753 | 53556 | 70621026 |
Punctate keratitis | 21.20 | 9.98 | 21 | 253841 | 899 | 70673683 |
Acute respiratory distress syndrome | 21.19 | 9.98 | 76 | 253786 | 41178 | 70633404 |
Blood pressure fluctuation | 21.19 | 9.98 | 124 | 253738 | 58888 | 70615694 |
Cerebral haemorrhage | 21.08 | 9.98 | 110 | 253752 | 53754 | 70620828 |
Hepatic encephalopathy | 21.05 | 9.98 | 29 | 253833 | 22089 | 70652493 |
Malignant mesenteric neoplasm | 21.03 | 9.98 | 8 | 253854 | 53 | 70674529 |
Oesophageal carcinoma | 21.02 | 9.98 | 4 | 253858 | 9362 | 70665220 |
Granulocytopenia | 21.02 | 9.98 | 6 | 253856 | 10641 | 70663941 |
Cardiomyopathy | 20.93 | 9.98 | 39 | 253823 | 26334 | 70648248 |
Renal cancer | 20.91 | 9.98 | 8 | 253854 | 11788 | 70662794 |
Blue toe syndrome | 20.75 | 9.98 | 17 | 253845 | 566 | 70674016 |
Flushing | 20.68 | 9.98 | 191 | 253671 | 81981 | 70592601 |
Diffuse large B-cell lymphoma | 20.50 | 9.98 | 11 | 253851 | 13291 | 70661291 |
Rheumatoid lung | 20.48 | 9.98 | 41 | 253821 | 3418 | 70671164 |
Pancreatic steatosis | 20.46 | 9.98 | 22 | 253840 | 1038 | 70673544 |
Haemorrhage intracranial | 20.23 | 9.98 | 36 | 253826 | 24741 | 70649841 |
No adverse event | 20.23 | 9.98 | 54 | 253808 | 32099 | 70642483 |
Throat irritation | 20.22 | 9.98 | 62 | 253800 | 35242 | 70639340 |
Peripheral sensory neuropathy | 20.20 | 9.98 | 9 | 253853 | 12101 | 70662481 |
Linear IgA disease | 20.19 | 9.98 | 37 | 253825 | 2887 | 70671695 |
Respiratory tract congestion | 20.18 | 9.98 | 20 | 253842 | 17633 | 70656949 |
Hypochromic anaemia | 20.07 | 9.98 | 34 | 253828 | 2493 | 70672089 |
Upper respiratory tract infection | 20.06 | 9.98 | 184 | 253678 | 79090 | 70595492 |
Blood calcium decreased | 20.06 | 9.98 | 46 | 253816 | 28800 | 70645782 |
Acquired porphyria | 20.04 | 9.98 | 7 | 253855 | 35 | 70674547 |
Hyperammonaemia | 19.95 | 9.98 | 6 | 253856 | 10287 | 70664295 |
Lower respiratory tract infection viral | 19.76 | 9.98 | 22 | 253840 | 1080 | 70673502 |
Abnormal loss of weight | 19.66 | 9.98 | 67 | 253795 | 7717 | 70666865 |
Intentional product use issue | 19.58 | 9.98 | 566 | 253296 | 119576 | 70555006 |
Candida infection | 19.42 | 9.98 | 61 | 253801 | 34412 | 70640170 |
Tumour lysis syndrome | 19.34 | 9.98 | 29 | 253833 | 21331 | 70653251 |
Adrenal insufficiency | 19.34 | 9.98 | 38 | 253824 | 25157 | 70649425 |
Faeces discoloured | 19.33 | 9.98 | 163 | 253699 | 26646 | 70647936 |
Stress | 19.33 | 9.98 | 153 | 253709 | 67813 | 70606769 |
Blood potassium decreased | 19.32 | 9.98 | 82 | 253780 | 42339 | 70632243 |
International normalised ratio increased | 19.31 | 9.98 | 190 | 253672 | 80536 | 70594046 |
Sopor | 19.30 | 9.98 | 53 | 253809 | 31214 | 70643368 |
Jejunal ulcer | 19.17 | 9.98 | 11 | 253851 | 201 | 70674381 |
Lip ulceration | 19.17 | 9.98 | 30 | 253832 | 2058 | 70672524 |
Gastrointestinal haemorrhage | 19.12 | 9.98 | 635 | 253227 | 136773 | 70537809 |
Gallbladder adenocarcinoma | 19.03 | 9.98 | 9 | 253853 | 108 | 70674474 |
Laboratory test abnormal | 18.93 | 9.98 | 40 | 253822 | 25783 | 70648799 |
Productive cough | 18.90 | 9.98 | 184 | 253678 | 78153 | 70596429 |
Hepatotoxicity | 18.84 | 9.98 | 87 | 253775 | 43899 | 70630683 |
Product administered at inappropriate site | 18.78 | 9.98 | 39 | 253823 | 3337 | 70671245 |
Application site erythema | 18.75 | 9.98 | 48 | 253814 | 4713 | 70669869 |
Depressed mood | 18.58 | 9.98 | 87 | 253775 | 43733 | 70630849 |
Erosive duodenitis | 18.57 | 9.98 | 27 | 253835 | 1735 | 70672847 |
Immunosuppressant drug level increased | 18.57 | 9.98 | 3 | 253859 | 7904 | 70666678 |
Aplasia cutis congenita | 18.55 | 9.98 | 4 | 253858 | 0 | 70674582 |
Urine porphobilinogen increased | 18.55 | 9.98 | 4 | 253858 | 0 | 70674582 |
Application site ulcer | 18.53 | 9.98 | 9 | 253853 | 115 | 70674467 |
Soft tissue infection | 18.53 | 9.98 | 40 | 253822 | 3517 | 70671065 |
Overdose | 18.52 | 9.98 | 464 | 253398 | 169281 | 70505301 |
Electrocardiogram QRS complex prolonged | 18.50 | 9.98 | 6 | 253856 | 9800 | 70664782 |
Anuria | 18.38 | 9.98 | 127 | 253735 | 19526 | 70655056 |
Eschar | 18.37 | 9.98 | 22 | 253840 | 1169 | 70673413 |
Feeding disorder | 18.30 | 9.98 | 101 | 253761 | 14355 | 70660227 |
Injection site bruising | 18.27 | 9.98 | 72 | 253790 | 37960 | 70636622 |
Vaccination site reaction | 18.19 | 9.98 | 9 | 253853 | 120 | 70674462 |
Blood glucose decreased | 18.07 | 9.98 | 37 | 253825 | 24122 | 70650460 |
Intestinal congestion | 18.07 | 9.98 | 5 | 253857 | 9 | 70674573 |
Lethargy | 18.04 | 9.98 | 177 | 253685 | 75073 | 70599509 |
Hypoproteinaemia | 18.01 | 9.98 | 40 | 253822 | 3586 | 70670996 |
Muscle tone disorder | 18.00 | 9.98 | 9 | 253853 | 123 | 70674459 |
Product quality issue | 17.99 | 9.98 | 53 | 253809 | 30508 | 70644074 |
Pyloric stenosis | 17.97 | 9.98 | 14 | 253848 | 433 | 70674149 |
Hypoaldosteronism | 17.96 | 9.98 | 13 | 253849 | 359 | 70674223 |
Body mass index abnormal | 17.91 | 9.98 | 11 | 253851 | 229 | 70674353 |
Onychomadesis | 17.90 | 9.98 | 43 | 253819 | 4058 | 70670524 |
Ataxia | 17.84 | 9.98 | 35 | 253827 | 23182 | 70651400 |
Subdural haematoma | 17.84 | 9.98 | 50 | 253812 | 29248 | 70645334 |
Viral upper respiratory tract infection | 17.74 | 9.98 | 69 | 253793 | 8473 | 70666109 |
Angiocardiogram | 17.74 | 9.98 | 11 | 253851 | 233 | 70674349 |
Complications of intestinal transplant | 17.72 | 9.98 | 5 | 253857 | 10 | 70674572 |
Drug tolerance decreased | 17.71 | 9.98 | 76 | 253786 | 9757 | 70664825 |
Tongue disorder | 17.54 | 9.98 | 13 | 253849 | 13214 | 70661368 |
Spinal fusion surgery | 17.54 | 9.98 | 42 | 253820 | 3955 | 70670627 |
Pulseless electrical activity | 17.51 | 9.98 | 13 | 253849 | 13202 | 70661380 |
Coronary artery disease | 17.49 | 9.98 | 142 | 253720 | 62594 | 70611988 |
Nephrotic syndrome | 17.47 | 9.98 | 80 | 253782 | 10560 | 70664022 |
Atrioventricular block | 17.44 | 9.98 | 12 | 253850 | 12676 | 70661906 |
Neonatal respiratory distress syndrome | 17.41 | 9.98 | 11 | 253851 | 241 | 70674341 |
Haemophagocytic lymphohistiocytosis | 17.40 | 9.98 | 27 | 253835 | 19585 | 70654997 |
Injection site hyperaesthesia | 17.38 | 9.98 | 7 | 253855 | 55 | 70674527 |
Basal cell carcinoma | 17.36 | 9.98 | 62 | 253800 | 33636 | 70640946 |
Creutzfeldt-Jakob disease | 17.32 | 9.98 | 10 | 253852 | 185 | 70674397 |
Myelodysplastic syndrome | 17.28 | 9.98 | 52 | 253810 | 29733 | 70644849 |
Drug level decreased | 17.28 | 9.98 | 12 | 253850 | 12612 | 70661970 |
Foot operation | 17.13 | 9.98 | 47 | 253815 | 4810 | 70669772 |
Hypogammaglobulinaemia | 17.12 | 9.98 | 10 | 253852 | 11528 | 70663054 |
Drug dependence | 17.09 | 9.98 | 72 | 253790 | 37249 | 70637333 |
Abdominal rebound tenderness | 17.06 | 9.98 | 7 | 253855 | 58 | 70674524 |
Psychomotor hyperactivity | 17.06 | 9.98 | 18 | 253844 | 15415 | 70659167 |
Bacterial infection | 17.04 | 9.98 | 44 | 253818 | 26448 | 70648134 |
Epilepsy | 17.04 | 9.98 | 76 | 253786 | 38708 | 70635874 |
Dementia | 16.94 | 9.98 | 34 | 253828 | 22331 | 70652251 |
Disease recurrence | 16.94 | 9.98 | 73 | 253789 | 37530 | 70637052 |
Sinus disorder | 16.92 | 9.98 | 26 | 253836 | 18933 | 70655649 |
Fibrosis | 16.91 | 9.98 | 47 | 253815 | 4847 | 70669735 |
Aplasia pure red cell | 16.87 | 9.98 | 3 | 253859 | 7371 | 70667211 |
Neutrophil count increased | 16.86 | 9.98 | 45 | 253817 | 26750 | 70647832 |
Vascular device infection | 16.85 | 9.98 | 4 | 253858 | 8026 | 70666556 |
Salivary hypersecretion | 16.76 | 9.98 | 13 | 253849 | 12912 | 70661670 |
Immunodeficiency | 16.72 | 9.98 | 23 | 253839 | 17532 | 70657050 |
Ventricular fibrillation | 16.70 | 9.98 | 46 | 253816 | 27065 | 70647517 |
Asthma | 16.69 | 9.98 | 318 | 253544 | 120475 | 70554107 |
Blood pressure measurement | 16.69 | 9.98 | 13 | 253849 | 402 | 70674180 |
Peritonitis bacterial | 16.67 | 9.98 | 6 | 253856 | 9178 | 70665404 |
Sebaceous gland infection | 16.63 | 9.98 | 9 | 253853 | 146 | 70674436 |
Small intestine carcinoma | 16.61 | 9.98 | 19 | 253843 | 961 | 70673621 |
Nerve stimulation test abnormal | 16.56 | 9.98 | 5 | 253857 | 14 | 70674568 |
Clostridium difficile colitis | 16.55 | 9.98 | 51 | 253811 | 28945 | 70645637 |
Porphyria | 16.55 | 9.98 | 10 | 253852 | 202 | 70674380 |
Application site swelling | 16.52 | 9.98 | 16 | 253846 | 666 | 70673916 |
Movement disorder | 16.51 | 9.98 | 145 | 253717 | 23984 | 70650598 |
Sciatic nerve injury | 16.49 | 9.98 | 14 | 253848 | 490 | 70674092 |
Aplasia | 16.48 | 9.98 | 3 | 253859 | 7248 | 70667334 |
Face oedema | 16.48 | 9.98 | 152 | 253710 | 25487 | 70649095 |
Bronchitis | 16.40 | 9.98 | 308 | 253554 | 116935 | 70557647 |
Mesenteric neoplasm | 16.37 | 9.98 | 7 | 253855 | 65 | 70674517 |
Blood lactate dehydrogenase increased | 16.32 | 9.98 | 195 | 253667 | 34932 | 70639650 |
Erythematotelangiectatic rosacea | 16.30 | 9.98 | 5 | 253857 | 15 | 70674567 |
Oral pruritus | 16.29 | 9.98 | 27 | 253835 | 1944 | 70672638 |
Jaundice | 16.29 | 9.98 | 261 | 253601 | 49847 | 70624735 |
Autoimmune disorder | 16.27 | 9.98 | 68 | 253794 | 8628 | 70665954 |
Emotional distress | 16.26 | 9.98 | 73 | 253789 | 37115 | 70637467 |
Panniculitis | 16.20 | 9.98 | 9 | 253853 | 10667 | 70663915 |
Postictal paralysis | 16.16 | 9.98 | 12 | 253850 | 345 | 70674237 |
Blood test abnormal | 16.14 | 9.98 | 17 | 253845 | 14573 | 70660009 |
Unintentional medical device removal | 16.08 | 9.98 | 3 | 253859 | 7121 | 70667461 |
Cushingoid | 16.06 | 9.98 | 5 | 253857 | 8383 | 70666199 |
Acute myocardial infarction | 16.02 | 9.98 | 175 | 253687 | 72712 | 70601870 |
Undifferentiated connective tissue disease | 16.00 | 9.98 | 6 | 253856 | 38 | 70674544 |
Libido increased | 15.99 | 9.98 | 26 | 253836 | 1843 | 70672739 |
Full blood count decreased | 15.95 | 9.98 | 39 | 253823 | 23879 | 70650703 |
Influenza like illness | 15.95 | 9.98 | 153 | 253709 | 65178 | 70609404 |
Mania | 15.86 | 9.98 | 23 | 253839 | 17151 | 70657431 |
Insomnia | 15.84 | 9.98 | 628 | 253234 | 217178 | 70457404 |
Colitis erosive | 15.83 | 9.98 | 8 | 253854 | 112 | 70674470 |
Small intestinal obstruction | 15.82 | 9.98 | 41 | 253821 | 24614 | 70649968 |
Musculoskeletal disorder | 15.79 | 9.98 | 124 | 253738 | 19847 | 70654735 |
Haematocrit decreased | 15.78 | 9.98 | 130 | 253732 | 57128 | 70617454 |
Chills | 15.73 | 9.98 | 396 | 253466 | 144390 | 70530192 |
Renal tubular necrosis | 15.73 | 9.98 | 139 | 253723 | 23032 | 70651550 |
Hyperventilation | 15.71 | 9.98 | 59 | 253803 | 7127 | 70667455 |
Injection site erythema | 15.67 | 9.98 | 176 | 253686 | 72748 | 70601834 |
Spondyloarthropathy | 15.63 | 9.98 | 18 | 253844 | 917 | 70673665 |
Bursitis | 15.59 | 9.98 | 155 | 253707 | 26518 | 70648064 |
Troponin increased | 15.59 | 9.98 | 22 | 253840 | 16592 | 70657990 |
Partial seizures | 15.52 | 9.98 | 5 | 253857 | 8200 | 70666382 |
Pneumonitis | 15.48 | 9.98 | 123 | 253739 | 54474 | 70620108 |
Iron deficiency anaemia | 15.45 | 9.98 | 138 | 253724 | 22934 | 70651648 |
Cardiac massage | 15.41 | 9.98 | 5 | 253857 | 19 | 70674563 |
Therapy cessation | 15.40 | 9.98 | 65 | 253797 | 33611 | 70640971 |
Device leakage | 15.40 | 9.98 | 7 | 253855 | 9301 | 70665281 |
Eastern Cooperative Oncology Group performance status | 15.37 | 9.98 | 6 | 253856 | 43 | 70674539 |
Drug use disorder | 15.36 | 9.98 | 5 | 253857 | 8146 | 70666436 |
Intestinal obstruction | 15.35 | 9.98 | 79 | 253783 | 38746 | 70635836 |
Osteonecrosis of jaw | 15.34 | 9.98 | 85 | 253777 | 40917 | 70633665 |
Atrial flutter | 15.31 | 9.98 | 31 | 253831 | 20296 | 70654286 |
COVID-19 pneumonia | 15.30 | 9.98 | 35 | 253827 | 21934 | 70652648 |
Myoclonus | 15.30 | 9.98 | 46 | 253816 | 26309 | 70648273 |
Fixed eruption | 15.28 | 9.98 | 30 | 253832 | 2466 | 70672116 |
Hepatitis C | 15.24 | 9.98 | 14 | 253848 | 12793 | 70661789 |
Sciatic nerve palsy | 15.18 | 9.98 | 7 | 253855 | 79 | 70674503 |
Application site oedema | 15.18 | 9.98 | 7 | 253855 | 79 | 70674503 |
Pseudomonas infection | 15.15 | 9.98 | 28 | 253834 | 18966 | 70655616 |
Omental necrosis | 15.14 | 9.98 | 6 | 253856 | 45 | 70674537 |
Head titubation | 15.13 | 9.98 | 17 | 253845 | 843 | 70673739 |
Depressed level of consciousness | 15.08 | 9.98 | 221 | 253641 | 87210 | 70587372 |
Papulopustular rosacea | 15.01 | 9.98 | 5 | 253857 | 21 | 70674561 |
Platelet dysfunction | 15.00 | 9.98 | 12 | 253850 | 386 | 70674196 |
Vaginal ulceration | 14.96 | 9.98 | 10 | 253852 | 242 | 70674340 |
Cystitis haemorrhagic | 14.95 | 9.98 | 6 | 253856 | 8587 | 70665995 |
Fungal infection | 14.95 | 9.98 | 76 | 253786 | 37391 | 70637191 |
Injection site pain | 14.94 | 9.98 | 314 | 253548 | 117305 | 70557277 |
Wound infection pseudomonas | 14.88 | 9.98 | 23 | 253839 | 1561 | 70673021 |
Abdominal tenderness | 14.86 | 9.98 | 72 | 253790 | 9728 | 70664854 |
Application site injury | 14.83 | 9.98 | 5 | 253857 | 22 | 70674560 |
Oculomucocutaneous syndrome | 14.82 | 9.98 | 11 | 253851 | 316 | 70674266 |
Multiple-drug resistance | 14.79 | 9.98 | 4 | 253858 | 7351 | 70667231 |
Injection site ulcer | 14.70 | 9.98 | 15 | 253847 | 666 | 70673916 |
Sexual dysfunction | 14.69 | 9.98 | 3 | 253859 | 6678 | 70667904 |
Pneumonia bacterial | 14.68 | 9.98 | 23 | 253839 | 16618 | 70657964 |
Sinus bradycardia | 14.62 | 9.98 | 40 | 253822 | 23583 | 70650999 |
Walking aid user | 14.61 | 9.98 | 62 | 253800 | 7919 | 70666663 |
Nodule | 14.58 | 9.98 | 31 | 253831 | 19938 | 70654644 |
Blood calcium increased | 14.51 | 9.98 | 7 | 253855 | 8986 | 70665596 |
Cholestasis | 14.45 | 9.98 | 106 | 253756 | 47766 | 70626816 |
Urine abnormality | 14.43 | 9.98 | 5 | 253857 | 7833 | 70666749 |
Aphasia | 14.42 | 9.98 | 93 | 253769 | 43156 | 70631426 |
Ventricular arrhythmia | 14.41 | 9.98 | 5 | 253857 | 7825 | 70666757 |
Iris transillumination defect | 14.40 | 9.98 | 8 | 253854 | 137 | 70674445 |
Ischaemic stroke | 14.40 | 9.98 | 59 | 253803 | 30761 | 70643821 |
Haemoglobin decreased | 14.39 | 9.98 | 594 | 253268 | 204565 | 70470017 |
Diverticulum intestinal | 14.37 | 9.98 | 62 | 253800 | 7979 | 70666603 |
Central nervous system lesion | 14.36 | 9.98 | 14 | 253848 | 12439 | 70662143 |
Central pain syndrome | 14.35 | 9.98 | 11 | 253851 | 332 | 70674250 |
Skin toxicity | 14.31 | 9.98 | 4 | 253858 | 7194 | 70667388 |
Breast cancer female | 14.31 | 9.98 | 10 | 253852 | 10476 | 70664106 |
Meralgia paraesthetica | 14.28 | 9.98 | 12 | 253850 | 414 | 70674168 |
Sleep disorder due to a general medical condition | 14.28 | 9.98 | 10 | 253852 | 10466 | 70664116 |
Gastritis haemorrhagic | 14.26 | 9.98 | 29 | 253833 | 2445 | 70672137 |
Transaminases increased | 14.24 | 9.98 | 104 | 253758 | 46914 | 70627668 |
Terminal insomnia | 14.23 | 9.98 | 18 | 253844 | 1012 | 70673570 |
Arthritis | 14.19 | 9.98 | 455 | 253407 | 97525 | 70577057 |
Lip scab | 14.18 | 9.98 | 4 | 253858 | 8 | 70674574 |
Tardive dyskinesia | 14.18 | 9.98 | 9 | 253853 | 9920 | 70664662 |
Factor VIII deficiency | 14.15 | 9.98 | 8 | 253854 | 142 | 70674440 |
Aspiration | 14.15 | 9.98 | 26 | 253836 | 17649 | 70656933 |
Cardiomegaly | 14.13 | 9.98 | 43 | 253819 | 24502 | 70650080 |
Treatment noncompliance | 14.12 | 9.98 | 103 | 253759 | 46471 | 70628111 |
Red blood cell count decreased | 14.11 | 9.98 | 119 | 253743 | 52042 | 70622540 |
Lip oedema | 14.05 | 9.98 | 48 | 253814 | 5535 | 70669047 |
Pulmonary mass | 14.02 | 9.98 | 47 | 253815 | 25986 | 70648596 |
Oral pain | 13.98 | 9.98 | 55 | 253807 | 29011 | 70645571 |
Inflammatory pain | 13.98 | 9.98 | 17 | 253845 | 918 | 70673664 |
Pulmonary haemorrhage | 13.97 | 9.98 | 17 | 253845 | 13656 | 70660926 |
Thrombosis | 13.93 | 9.98 | 188 | 253674 | 75217 | 70599365 |
Internal limiting membrane peeling | 13.91 | 9.98 | 3 | 253859 | 0 | 70674582 |
Respiratory syncytial virus infection | 13.89 | 9.98 | 5 | 253857 | 7650 | 70666932 |
Hypermobility syndrome | 13.88 | 9.98 | 13 | 253849 | 519 | 70674063 |
Fear | 13.82 | 9.98 | 34 | 253828 | 20777 | 70653805 |
Discoloured vomit | 13.81 | 9.98 | 20 | 253842 | 1281 | 70673301 |
Respiratory acidosis | 13.77 | 9.98 | 10 | 253852 | 10271 | 70664311 |
Spondylitis | 13.77 | 9.98 | 35 | 253827 | 3422 | 70671160 |
Encephalitis | 13.76 | 9.98 | 17 | 253845 | 13568 | 70661014 |
Basal ganglion degeneration | 13.76 | 9.98 | 12 | 253850 | 436 | 70674146 |
Bone marrow oedema | 13.71 | 9.98 | 21 | 253841 | 1414 | 70673168 |
Porphyrins urine increased | 13.70 | 9.98 | 5 | 253857 | 29 | 70674553 |
Post-traumatic neck syndrome | 13.67 | 9.98 | 25 | 253837 | 1948 | 70672634 |
Gastrointestinal mucosal exfoliation | 13.60 | 9.98 | 9 | 253853 | 214 | 70674368 |
Eyelid oedema | 13.58 | 9.98 | 85 | 253777 | 12642 | 70661940 |
Pyoderma streptococcal | 13.57 | 9.98 | 4 | 253858 | 10 | 70674572 |
Staphylococcal infection | 13.49 | 9.98 | 124 | 253738 | 53280 | 70621302 |
Seroma | 13.49 | 9.98 | 26 | 253836 | 2108 | 70672474 |
Nail operation | 13.49 | 9.98 | 13 | 253849 | 538 | 70674044 |
Arrhythmia | 13.48 | 9.98 | 132 | 253730 | 56011 | 70618571 |
Acquired haemophilia | 13.46 | 9.98 | 24 | 253838 | 1833 | 70672749 |
Alanine aminotransferase abnormal | 13.42 | 9.98 | 6 | 253856 | 8053 | 70666529 |
Breast cancer metastatic | 13.42 | 9.98 | 10 | 253852 | 10136 | 70664446 |
Atrioventricular block complete | 13.33 | 9.98 | 21 | 253841 | 15142 | 70659440 |
Device occlusion | 13.31 | 9.98 | 11 | 253851 | 10584 | 70663998 |
Heart rate irregular | 13.24 | 9.98 | 58 | 253804 | 29685 | 70644897 |
Parotid gland enlargement | 13.21 | 9.98 | 16 | 253846 | 860 | 70673722 |
Hiccups | 13.21 | 9.98 | 8 | 253854 | 9044 | 70665538 |
Vasoconstriction | 13.21 | 9.98 | 14 | 253848 | 650 | 70673932 |
Gynaecomastia | 13.19 | 9.98 | 4 | 253858 | 6819 | 70667763 |
Intestinal metaplasia | 13.16 | 9.98 | 5 | 253857 | 33 | 70674549 |
Peptic ulcer haemorrhage | 13.16 | 9.98 | 16 | 253846 | 864 | 70673718 |
Small intestinal ulcer haemorrhage | 13.13 | 9.98 | 7 | 253855 | 110 | 70674472 |
Respiratory disorder | 13.11 | 9.98 | 84 | 253778 | 39039 | 70635543 |
Palatal oedema | 13.09 | 9.98 | 19 | 253843 | 1219 | 70673363 |
Haemorrhage | 13.05 | 9.98 | 216 | 253646 | 83599 | 70590983 |
Meteoropathy | 13.04 | 9.98 | 4 | 253858 | 12 | 70674570 |
Oral mucosa erosion | 13.04 | 9.98 | 23 | 253839 | 1742 | 70672840 |
Intervertebral disc disorder | 12.95 | 9.98 | 41 | 253821 | 4544 | 70670038 |
Influenza | 12.89 | 9.98 | 309 | 253553 | 113391 | 70561191 |
Acquired diaphragmatic eventration | 12.81 | 9.98 | 13 | 253849 | 573 | 70674009 |
Intestinal haemorrhage | 12.81 | 9.98 | 49 | 253813 | 5971 | 70668611 |
C-reactive protein | 12.76 | 9.98 | 25 | 253837 | 2051 | 70672531 |
Gastric mucosal lesion | 12.68 | 9.98 | 16 | 253846 | 897 | 70673685 |
Platelet function test abnormal | 12.68 | 9.98 | 8 | 253854 | 175 | 70674407 |
Hypothermia | 12.65 | 9.98 | 35 | 253827 | 20559 | 70654023 |
Aortic stenosis | 12.57 | 9.98 | 4 | 253858 | 6612 | 70667970 |
Condition aggravated | 12.54 | 9.98 | 1730 | 252132 | 425905 | 70248677 |
Tarsal tunnel syndrome | 12.52 | 9.98 | 12 | 253850 | 493 | 70674089 |
Atrioventricular block first degree | 12.47 | 9.98 | 14 | 253848 | 11659 | 70662923 |
Injection site haemorrhage | 12.47 | 9.98 | 48 | 253814 | 25479 | 70649103 |
Pulmonary thrombosis | 12.47 | 9.98 | 13 | 253849 | 11195 | 70663387 |
Secondary amyloidosis | 12.44 | 9.98 | 8 | 253854 | 181 | 70674401 |
Arterial haemorrhage | 12.43 | 9.98 | 27 | 253835 | 2384 | 70672198 |
Blood triglycerides increased | 12.39 | 9.98 | 33 | 253829 | 19631 | 70654951 |
Duodenal stenosis | 12.38 | 9.98 | 14 | 253848 | 699 | 70673883 |
Hypertensive crisis | 12.38 | 9.98 | 32 | 253830 | 19230 | 70655352 |
Hepatic cytolysis | 12.25 | 9.98 | 32 | 253830 | 19160 | 70655422 |
Alpha tumour necrosis factor increased | 12.23 | 9.98 | 5 | 253857 | 41 | 70674541 |
Coronary arterial stent insertion | 12.22 | 9.98 | 3 | 253859 | 5884 | 70668698 |
Pneumatosis intestinalis | 12.22 | 9.98 | 3 | 253859 | 5884 | 70668698 |
Pyrexia | 12.22 | 9.98 | 1947 | 251915 | 605005 | 70069577 |
Injection site abscess | 12.21 | 9.98 | 20 | 253842 | 1426 | 70673156 |
Electrolyte imbalance | 12.19 | 9.98 | 52 | 253810 | 26809 | 70647773 |
Oligoarthritis | 12.13 | 9.98 | 12 | 253850 | 513 | 70674069 |
Intentional product misuse | 12.11 | 9.98 | 206 | 253656 | 79389 | 70595193 |
Application site pain | 12.11 | 9.98 | 39 | 253823 | 4363 | 70670219 |
Erythema multiforme | 12.10 | 9.98 | 101 | 253761 | 16463 | 70658119 |
Underdose | 12.07 | 9.98 | 59 | 253803 | 29324 | 70645258 |
Multiple sclerosis | 12.06 | 9.98 | 48 | 253814 | 25237 | 70649345 |
Mood swings | 12.05 | 9.98 | 30 | 253832 | 18256 | 70656326 |
Arteriosclerosis coronary artery | 11.98 | 9.98 | 25 | 253837 | 16190 | 70658392 |
Breath sounds abnormal | 11.95 | 9.98 | 18 | 253844 | 13213 | 70661369 |
Haemorrhoids | 11.94 | 9.98 | 49 | 253813 | 25539 | 70649043 |
Porphyrins stool increased | 11.93 | 9.98 | 5 | 253857 | 44 | 70674538 |
Leucine aminopeptidase increased | 11.84 | 9.98 | 3 | 253859 | 3 | 70674579 |
Upper limb fracture | 11.79 | 9.98 | 25 | 253837 | 16094 | 70658488 |
Corneal opacity | 11.71 | 9.98 | 16 | 253846 | 970 | 70673612 |
Neoplasm malignant | 11.69 | 9.98 | 58 | 253804 | 28716 | 70645866 |
Fistula | 11.68 | 9.98 | 13 | 253849 | 10868 | 70663714 |
Vascular malformation | 11.66 | 9.98 | 10 | 253852 | 355 | 70674227 |
Carbohydrate antigen 15-3 | 11.62 | 9.98 | 6 | 253856 | 88 | 70674494 |
Hyperlipidaemia | 11.58 | 9.98 | 45 | 253817 | 23818 | 70650764 |
Renal impairment | 11.57 | 9.98 | 410 | 253452 | 143527 | 70531055 |
Pulmonary alveolar haemorrhage | 11.57 | 9.98 | 12 | 253850 | 10357 | 70664225 |
Oesophageal carcinoma recurrent | 11.55 | 9.98 | 5 | 253857 | 48 | 70674534 |
Hemiplegia | 11.52 | 9.98 | 20 | 253842 | 13875 | 70660707 |
Jejunal stenosis | 11.50 | 9.98 | 6 | 253856 | 90 | 70674492 |
Abdominal lymphadenopathy | 11.49 | 9.98 | 18 | 253844 | 1236 | 70673346 |
Dyspnoea at rest | 11.48 | 9.98 | 5 | 253857 | 6814 | 70667768 |
Anal fissure | 11.44 | 9.98 | 4 | 253858 | 6229 | 70668353 |
Pulmonary function test decreased | 11.43 | 9.98 | 5 | 253857 | 6796 | 70667786 |
Application site exfoliation | 11.40 | 9.98 | 10 | 253852 | 366 | 70674216 |
Carcinoembryonic antigen | 11.39 | 9.98 | 6 | 253856 | 92 | 70674490 |
Toxic epidermal necrolysis | 11.38 | 9.98 | 202 | 253660 | 39355 | 70635227 |
Atrioventricular block second degree | 11.36 | 9.98 | 5 | 253857 | 6773 | 70667809 |
Laryngeal discomfort | 11.36 | 9.98 | 12 | 253850 | 555 | 70674027 |
Pallor | 11.35 | 9.98 | 208 | 253654 | 40766 | 70633816 |
Respiratory tract infection | 11.35 | 9.98 | 97 | 253765 | 42301 | 70632281 |
Angina unstable | 11.33 | 9.98 | 25 | 253837 | 15868 | 70658714 |
Exposure to toxic agent | 11.32 | 9.98 | 4 | 253858 | 6190 | 70668392 |
Disability | 11.29 | 9.98 | 92 | 253770 | 14891 | 70659691 |
Herpes zoster | 11.28 | 9.98 | 226 | 253636 | 85009 | 70589573 |
Embolic stroke | 11.27 | 9.98 | 6 | 253856 | 7283 | 70667299 |
Lentigo maligna | 11.22 | 9.98 | 11 | 253851 | 465 | 70674117 |
Inflammatory marker increased | 11.21 | 9.98 | 64 | 253798 | 9210 | 70665372 |
Persistent corneal epithelial defect | 11.20 | 9.98 | 5 | 253857 | 52 | 70674530 |
Acute lymphocytic leukaemia | 11.18 | 9.98 | 3 | 253859 | 5542 | 70669040 |
Haemolysis | 11.14 | 9.98 | 15 | 253847 | 11536 | 70663046 |
Accidental exposure to product | 11.14 | 9.98 | 57 | 253805 | 27994 | 70646588 |
Vomiting | 11.13 | 9.98 | 1910 | 251952 | 591201 | 70083381 |
Multiple allergies | 11.13 | 9.98 | 7 | 253855 | 7753 | 70666829 |
Glycosylated haemoglobin increased | 11.10 | 9.98 | 29 | 253833 | 17362 | 70657220 |
Chest pain | 11.10 | 9.98 | 762 | 253100 | 250498 | 70424084 |
Analgesic drug level increased | 11.08 | 9.98 | 26 | 253836 | 2417 | 70672165 |
Gallbladder oedema | 11.08 | 9.98 | 9 | 253853 | 296 | 70674286 |
Prurigo | 11.08 | 9.98 | 18 | 253844 | 1275 | 70673307 |
Tremor | 11.03 | 9.98 | 450 | 253412 | 155174 | 70519408 |
Rhinorrhoea | 11.02 | 9.98 | 169 | 253693 | 66202 | 70608380 |
Mallory-Weiss syndrome | 10.99 | 9.98 | 27 | 253835 | 2584 | 70671998 |
Axial spondyloarthritis | 10.99 | 9.98 | 11 | 253851 | 477 | 70674105 |
Sinus node dysfunction | 10.94 | 9.98 | 6 | 253856 | 7163 | 70667419 |
Epstein-Barr virus infection | 10.94 | 9.98 | 19 | 253843 | 13179 | 70661403 |
Laparotomy | 10.85 | 9.98 | 10 | 253852 | 391 | 70674191 |
Drooling | 10.85 | 9.98 | 3 | 253859 | 5433 | 70669149 |
Squamous cell carcinoma of skin | 10.81 | 9.98 | 18 | 253844 | 12694 | 70661888 |
Breast cancer stage III | 10.80 | 9.98 | 50 | 253812 | 6631 | 70667951 |
HLA-B*27 positive | 10.79 | 9.98 | 6 | 253856 | 103 | 70674479 |
Skin graft | 10.77 | 9.98 | 15 | 253847 | 926 | 70673656 |
Euglycaemic diabetic ketoacidosis | 10.77 | 9.98 | 4 | 253858 | 6003 | 70668579 |
Lividity | 10.76 | 9.98 | 10 | 253852 | 395 | 70674187 |
Taste disorder | 10.76 | 9.98 | 15 | 253847 | 11370 | 70663212 |
Gestational diabetes | 10.76 | 9.98 | 4 | 253858 | 5997 | 70668585 |
Creatinine renal clearance decreased | 10.73 | 9.98 | 29 | 253833 | 17171 | 70657411 |
Blood glucose abnormal | 10.73 | 9.98 | 11 | 253851 | 9546 | 70665036 |
Heavy menstrual bleeding | 10.71 | 9.98 | 18 | 253844 | 12647 | 70661935 |
Angina pectoris | 10.70 | 9.98 | 116 | 253746 | 48267 | 70626315 |
Duodenal perforation | 10.69 | 9.98 | 23 | 253839 | 2017 | 70672565 |
Hypertension | 10.68 | 9.98 | 913 | 252949 | 295120 | 70379462 |
Onychomycosis | 10.68 | 9.98 | 51 | 253811 | 6850 | 70667732 |
Therapy interrupted | 10.66 | 9.98 | 49 | 253813 | 24753 | 70649829 |
Heparin-induced thrombocytopenia | 10.61 | 9.98 | 10 | 253852 | 9027 | 70665555 |
Metastases to liver | 10.61 | 9.98 | 52 | 253810 | 25826 | 70648756 |
Hepatitis B reactivation | 10.60 | 9.98 | 3 | 253859 | 5352 | 70669230 |
Pancreatitis acute | 10.58 | 9.98 | 107 | 253755 | 45117 | 70629465 |
Systemic candida | 10.56 | 9.98 | 4 | 253858 | 5930 | 70668652 |
Injection site swelling | 10.56 | 9.98 | 101 | 253761 | 43056 | 70631526 |
Anorgasmia | 10.54 | 9.98 | 16 | 253846 | 1069 | 70673513 |
Wound necrosis | 10.54 | 9.98 | 12 | 253850 | 604 | 70673978 |
Complication of device insertion | 10.53 | 9.98 | 3 | 253859 | 5329 | 70669253 |
Paranasal cyst | 10.49 | 9.98 | 10 | 253852 | 408 | 70674174 |
Emphysema | 10.49 | 9.98 | 24 | 253838 | 15036 | 70659546 |
Metastases to central nervous system | 10.43 | 9.98 | 24 | 253838 | 15010 | 70659572 |
Loss of personal independence in daily activities | 10.40 | 9.98 | 228 | 253634 | 84682 | 70589900 |
Colorectal cancer | 10.39 | 9.98 | 9 | 253853 | 8461 | 70666121 |
Dactylitis | 10.38 | 9.98 | 24 | 253838 | 2209 | 70672373 |
Obstruction gastric | 10.35 | 9.98 | 19 | 253843 | 1485 | 70673097 |
Intestinal ischaemia | 10.33 | 9.98 | 17 | 253845 | 12047 | 70662535 |
Coagulopathy | 10.33 | 9.98 | 73 | 253789 | 33176 | 70641406 |
Mast cell activation syndrome | 10.33 | 9.98 | 12 | 253850 | 617 | 70673965 |
Supraventricular tachycardia | 10.33 | 9.98 | 36 | 253826 | 19674 | 70654908 |
Dystonia | 10.32 | 9.98 | 36 | 253826 | 19670 | 70654912 |
X-ray abnormal | 10.28 | 9.98 | 26 | 253836 | 2534 | 70672048 |
Sciatica | 10.28 | 9.98 | 134 | 253728 | 24493 | 70650089 |
Hostility | 10.23 | 9.98 | 24 | 253838 | 2231 | 70672351 |
Somnolence | 10.17 | 9.98 | 650 | 253212 | 214956 | 70459626 |
Episcleritis | 10.14 | 9.98 | 15 | 253847 | 979 | 70673603 |
Extradural abscess | 10.12 | 9.98 | 17 | 253845 | 1238 | 70673344 |
Respiratory depression | 10.12 | 9.98 | 50 | 253812 | 24781 | 70649801 |
Neuropathic ulcer | 10.09 | 9.98 | 5 | 253857 | 67 | 70674515 |
Malnutrition | 10.06 | 9.98 | 38 | 253824 | 20279 | 70654303 |
Procedural pain | 10.05 | 9.98 | 32 | 253830 | 17977 | 70656605 |
Liver function test abnormal | 10.05 | 9.98 | 156 | 253706 | 60990 | 70613592 |
Delusion | 10.05 | 9.98 | 35 | 253827 | 19130 | 70655452 |
Upper-airway cough syndrome | 10.04 | 9.98 | 12 | 253850 | 9719 | 70664863 |
Hypermetropia | 10.04 | 9.98 | 10 | 253852 | 431 | 70674151 |
Brain injury | 10.02 | 9.98 | 14 | 253848 | 10603 | 70663979 |
Ciliary hyperaemia | 10.02 | 9.98 | 5 | 253857 | 68 | 70674514 |
Application site dryness | 10.00 | 9.98 | 7 | 253855 | 183 | 70674399 |
pH body fluid decreased | 9.98 | 9.98 | 4 | 253858 | 31 | 70674551 |
Nasal congestion | 9.98 | 9.98 | 170 | 253692 | 65502 | 70609080 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Right ventricular hypertrophy | 36.53 | 33.34 | 8 | 116 | 15 | 89653 |
Source | Code | Description |
---|---|---|
ATC | D11AX18 | DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals |
ATC | M01AB05 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Acetic acid derivatives and related substances |
ATC | M01AB55 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Acetic acid derivatives and related substances |
ATC | M02AA15 | MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use |
ATC | S01BC03 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Antiinflammatory agents, non-steroids |
ATC | S01CC01 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Antiinflammatory agents, non-steroids and antiinfectives in combination |
FDA CS | M0001335 | Anti-Inflammatory Agents, Non-Steroidal |
FDA MoA | N0000000160 | Cyclooxygenase Inhibitors |
FDA PE | N0000008836 | Decreased Prostaglandin Production |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
MeSH PA | D016861 | Cyclooxygenase Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
FDA EPC | N0000175722 | Nonsteroidal Anti-inflammatory Drug |
CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
CHEBI has role | CHEBI:35493 | anti-pyretic |
CHEBI has role | CHEBI:35544 | cyclooxygenase inhibitors |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Ankylosing spondylitis | indication | 9631008 | DOID:7147 |
Pain | indication | 22253000 | |
Tenosynovitis | indication | 67801009 | DOID:970 |
Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
Actinic keratosis | indication | 201101007 | DOID:8866 |
Dysmenorrhea | indication | 266599000 | |
Lumbago | indication | 279039007 | |
Osteoarthritis | indication | 396275006 | |
Adhesive capsulitis of shoulder | indication | 399114005 | DOID:14188 |
Analgesia in various types of cancer | indication | ||
Osteoarthritis in Patients at High Ulcer Risk | indication | ||
Rheumatoid Arthritis in Patient at High Ulcer Risk | indication | ||
Post-Op Photophobia | indication | ||
Postoperative Ocular Pain | indication | ||
Sprains and Strains | indication | ||
Osteoarthrosis of the Knee | indication | ||
Post-Op Ocular Inflammation | indication | ||
Renal colic | off-label use | 7093002 | |
Tendinitis | off-label use | 34840004 | DOID:971 |
Bursitis | off-label use | 84017003 | DOID:2965 |
Cystoid macular edema | off-label use | 193387007 | DOID:4447 |
Prevention of Ocular Surgery-Induced Miosis | off-label use | ||
Keratitis | contraindication | 5888003 | DOID:4677 |
Alcoholism | contraindication | 7200002 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Asthenia | contraindication | 13791008 | |
Infection of skin AND/OR subcutaneous tissue | contraindication | 19824006 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
Dehydration | contraindication | 34095006 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Body fluid retention | contraindication | 43498006 | |
Skin ulcer | contraindication | 46742003 | |
Chronic heart failure | contraindication | 48447003 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Corneal erosion | contraindication | 50792001 | |
Duodenal ulcer disease | contraindication | 51868009 | DOID:1724 |
Gastrointestinal perforation | contraindication | 51875005 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Perforation of cornea | contraindication | 74895004 | |
Corneal ulcer | contraindication | 91514001 | DOID:8463 |
Corneal degeneration | contraindication | 111521006 | DOID:1237 |
Open wound | contraindication | 125643001 | |
Liver function tests abnormal | contraindication | 166603001 | |
Asthma | contraindication | 195967001 | DOID:2841 |
Deliveries by cesarean | contraindication | 200144004 | |
Cerebrovascular accident | contraindication | 230690007 | |
Coronary artery bypass graft | contraindication | 232717009 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Drug-induced hepatitis | contraindication | 235876009 | |
Edema | contraindication | 267038008 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thromboembolic disorder | contraindication | 371039008 | |
Cardiovascular event risk | contraindication | 395112001 | |
Smokes tobacco daily | contraindication | 449868002 | |
Gynecological Surgery | contraindication | ||
Uterine Rupture in Pregnancy | contraindication | ||
Bloody Vomit | contraindication | ||
Corneal Infiltrates | contraindication |
Species | Use | Relation |
---|---|---|
Horses | Pain and inflammation associated with osteoarthritis | Indication |
Product | Applicant | Ingredients |
---|---|---|
Surpass Topical Anti-Inflammatory Cream | Boehringer lngelheim Animal Health USA Inc. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.22 | acidic |
pKa2 | 0.55 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
50MG | CAMBIA | ASSERTIO | N022165 | June 17, 2009 | RX | FOR SOLUTION | ORAL | 7759394 | June 16, 2026 | ACUTE TREATMENT OF MIGRAINE ATTACKS WITH OR WITHOUT AURA IN ADULTS |
50MG | CAMBIA | ASSERTIO | N022165 | June 17, 2009 | RX | FOR SOLUTION | ORAL | 8097651 | June 16, 2026 | ACUTE TREATMENT OF MIGRAINE ATTACKS WITH OR WITHOUT AURA IN ADULTS |
50MG | CAMBIA | ASSERTIO | N022165 | June 17, 2009 | RX | FOR SOLUTION | ORAL | 8927604 | June 16, 2026 | ACUTE TREATMENT OF MIGRAINE ATTACKS WITH OR WITHOUT AURA IN ADULTS |
37.5MG/ML (37.5MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | DYLOJECT | JAVELIN PHARMS INC | N022396 | Dec. 23, 2014 | DISCN | SOLUTION | INTRAVENOUS | 8946292 | March 22, 2027 | MANAGEMENT OF PAIN |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 8563613 | Oct. 17, 2027 | USE OF TOPICAL DICLOFENAC FOR TREATING PAIN |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 8871809 | Oct. 17, 2027 | USE OF TOPICAL DICLOFENAC SODIUM FOR TREATING PAIN |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 9066913 | Oct. 17, 2027 | USE OF TOPICAL DICLOFENAC FOR TREATING PAIN |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 9101591 | Oct. 17, 2027 | USE OF TOPICAL DICLOFENAC FOR TREATING PAIN |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 9132110 | Oct. 17, 2027 | USE OF TOPICAL DICLOFENAC FOR TREATING PAIN |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 9168305 | Oct. 17, 2027 | USE OF TOPICAL DICLOFENAC FOR TREATING PAIN |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 9220784 | Oct. 17, 2027 | USE OF TOPICAL DICLOFENAC FOR TREATING PAIN |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 9339551 | Oct. 17, 2027 | USE OF TOPICAL DICLOFENAC FOR TREATING PAIN |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 9339552 | Oct. 17, 2027 | USE OF TOPICAL DICLOFENAC FOR TREATING PAIN |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 9539335 | Oct. 17, 2027 | USE OF TOPICAL DICLOFENAC SODIUM FOR TREATING PAIN |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 8252838 | April 21, 2028 | USE OF TOPICAL DICLOFENAC ON A JOINT FOR TREATING OSTEOARTHRITIS |
25MG | ZIPSOR | ASSERTIO | N022202 | June 16, 2009 | RX | CAPSULE | ORAL | 7662858 | Feb. 24, 2029 | NONSTEROIDAL ANTI-INFLAMMATORY DRUG INDICATED FOR RELIEF OF MILD TO MODERATE ACUTE PAIN |
25MG | ZIPSOR | ASSERTIO | N022202 | June 16, 2009 | RX | CAPSULE | ORAL | 7884095 | Feb. 24, 2029 | NONSTEROIDAL ANTI-INFLAMMATORY DRUG INDICATED FOR RELIEF OF MILD TO MODERATE ACUTE PAIN |
25MG | ZIPSOR | ASSERTIO | N022202 | June 16, 2009 | RX | CAPSULE | ORAL | 7939518 | Feb. 24, 2029 | NONSTEROIDAL ANTI-INFLAMMATORY DRUG INDICATED FOR RELIEF OF MILD TO MODERATE ACUTE PAIN |
25MG | ZIPSOR | ASSERTIO | N022202 | June 16, 2009 | RX | CAPSULE | ORAL | 8110606 | Feb. 24, 2029 | NONSTEROIDAL ANTI-INFLAMMATORY DRUG INDICATED FOR RELIEF OF MILD TO MODERATE ACUTE PAIN |
25MG | ZIPSOR | ASSERTIO | N022202 | June 16, 2009 | RX | CAPSULE | ORAL | 8623920 | Feb. 24, 2029 | DICLOFENAC POTASSIUM FOR RELIEF OF MILD TO MODERATE ACUTE PAIN |
25MG | ZIPSOR | ASSERTIO | N022202 | June 16, 2009 | RX | CAPSULE | ORAL | 9561200 | Feb. 24, 2029 | DICLOFENAC POTASSIUM FOR RELIEF OF MILD TO MODERATE ACUTE PAIN |
1.5% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | PENNSAID | NUVO PHARMS INC | N020947 | Nov. 4, 2009 | DISCN | SOLUTION | TOPICAL | 8217078 | July 10, 2029 | USE OF TOPICAL DICLOFENAC ON THE KNEE AND A SECOND TOPICAL MEDICATION ON THE SAME KNEE |
1.5% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | PENNSAID | NUVO PHARMS INC | N020947 | Nov. 4, 2009 | DISCN | SOLUTION | TOPICAL | 8618164 | July 10, 2029 | USE OF TOPICAL DICLOFENAC ON THE KNEE AND A SECOND TOPICAL PRESCRIPTION MEDICATION ON THE SAME KNEE |
1.5% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | PENNSAID | NUVO PHARMS INC | N020947 | Nov. 4, 2009 | DISCN | SOLUTION | TOPICAL | 8741956 | July 10, 2029 | COMBINATION USE OF TOPICAL DICLOFENAC ON THE KNEE AND ADMINISTRATION OF AN ORAL NSAID. |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 8217078 | July 10, 2029 | USE OF TOPICAL DICLOFENAC ON THE KNEE AND A SECOND TOPICAL PRESCRIPTION MEDICATION ON THE SAME KNEE |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 8618164 | July 10, 2029 | USE OF TOPICAL DICLOFENAC ON THE KNEE AND A SECOND TOPICAL PRESCRIPTION MEDICATION ON THE SAME KNEE |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 8741956 | July 10, 2029 | COMBINATION USE OF TOPICAL DICLOFENAC ON THE KNEE AND ADMINISTRATION OF AN ORAL NSAID. |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 9370501 | July 10, 2029 | USE OF TOPICAL DICLOFENAC SODIUM FOR TREATING PAIN |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 9375412 | July 10, 2029 | USE OF TOPICAL DICLOFENAC SODIUM FOR TREATING PAIN |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 9415029 | July 10, 2029 | USE OF TOPICAL DICLOFENAC SODIUM FOR TREATING PAIN |
18MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | ZORVOLEX | ZYLA | N204592 | Oct. 18, 2013 | DISCN | CAPSULE | ORAL | 8999387 | April 23, 2030 | TREATMENT OF PAIN |
18MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | ZORVOLEX | ZYLA | N204592 | Oct. 18, 2013 | DISCN | CAPSULE | ORAL | 9180095 | April 23, 2030 | TREATMENT OF PAIN |
18MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | ZORVOLEX | ZYLA | N204592 | Oct. 18, 2013 | DISCN | CAPSULE | ORAL | 9186328 | April 23, 2030 | TREATMENT OF PAIN |
35MG | ZORVOLEX | ZYLA | N204592 | Oct. 18, 2013 | DISCN | CAPSULE | ORAL | 8999387 | April 23, 2030 | TREATMENT OF PAIN |
35MG | ZORVOLEX | ZYLA | N204592 | Oct. 18, 2013 | DISCN | CAPSULE | ORAL | 9180095 | April 23, 2030 | TREATMENT OF PAIN |
35MG | ZORVOLEX | ZYLA | N204592 | Oct. 18, 2013 | DISCN | CAPSULE | ORAL | 9186328 | April 23, 2030 | TREATMENT OF PAIN |
1.5% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | PENNSAID | NUVO PHARMS INC | N020947 | Nov. 4, 2009 | DISCN | SOLUTION | TOPICAL | 8546450 | Aug. 9, 2030 | COMBINATION USE OF TOPICAL DICLOFENAC ON THE KNEE AND ADMINISTRATION OF AN ORAL NSAID. |
1.5% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | PENNSAID | NUVO PHARMS INC | N020947 | Nov. 4, 2009 | DISCN | SOLUTION | TOPICAL | 8546450 | Aug. 9, 2030 | USE OF TOPICAL DICLOFENAC ON THE KNEE AND A SECOND TOPICAL AGENT SELECTED FROM SUNSCREEN AND INSECT REPELLANT |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 8546450 | Aug. 9, 2030 | COMBINATION USE OF TOPICAL DICLOFENAC ON THE KNEE AND ADMINISTRATION OF AN ORAL NSAID. |
2% | PENNSAID | HORIZON | N204623 | Jan. 16, 2014 | RX | SOLUTION | TOPICAL | 8546450 | Aug. 9, 2030 | USE OF TOPICAL DICLOFENAC ON THE KNEE AND A SECOND TOPICAL AGENT SELECTED FROM SUNSCREEN AND INSECT REPELLANT |
1.3% | LICART | IBSA INST BIO | N206976 | Dec. 19, 2018 | RX | SYSTEM | TOPICAL | 11344520 | Feb. 20, 2035 | METHOD OF TREATING ACUTE PAIN DUE TO MINOR STRAINS, SPRAINS, AND CONTUSIONS USING A DICLOFENAC PATCH CONTAINING HEPARIN FOR ONCE DAILY ADMINISTRATION WHERE HEPARIN IS NOT RELEASED |
1.3% | LICART | IBSA INST BIO | N206976 | Dec. 19, 2018 | RX | SYSTEM | TOPICAL | 11351133 | Feb. 20, 2035 | METHOD OF TREATING ACUTE PAIN DUE TO MINOR STRAINS, SPRAINS, AND CONTUSIONS USING A DICLOFENAC PATCH CONTAINING HEPARIN FOR ONCE DAILY ADMINISTRATION WHERE HEPARIN IS NOT RELEASED |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
25MG | ZIPSOR | ASSERTIO | N022202 | June 16, 2009 | RX | CAPSULE | ORAL | May 25, 2024 | NEW PATIENT POPULATION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 7.70 | WOMBAT-PK | CHEMBL | |||
Prostaglandin G/H synthase 1 | Enzyme | INHIBITOR | IC50 | 7.52 | WOMBAT-PK | CHEMBL | |||
Transthyretin | Secreted | Kd | 6 | CHEMBL | |||||
Aldo-keto reductase family 1 member C3 | Enzyme | IC50 | 5.59 | CHEMBL | |||||
Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | ANTAGONIST | Ki | 6.20 | IUPHAR | ||||
Cytochrome c oxidase subunit 2 | Enzyme | IC50 | 5 | CHEMBL | |||||
Interleukin-8 | Cytokine | IC50 | 8.10 | CHEMBL | |||||
Transient receptor potential cation channel subfamily A member 1 | Ion channel | EC50 | 4.25 | CHEMBL | |||||
Aldo-keto reductase family 1 member B10 | Enzyme | IC50 | 5.72 | CHEMBL | |||||
Acid-sensing ion channel 3 | Ion channel | BLOCKER | IC50 | 4 | IUPHAR | ||||
C-X-C chemokine receptor type 1 | GPCR | IC50 | 7.92 | CHEMBL | |||||
UDP-glucuronosyltransferase 1-1 | Enzyme | Ki | 4.28 | CHEMBL | |||||
UDP-glucuronosyltransferase 1-7 | Enzyme | Ki | 4.72 | CHEMBL | |||||
UDP-glucuronosyltransferase 1-6 | Enzyme | Ki | 4.64 | CHEMBL | |||||
UDP-glucuronosyltransferase 1-9 | Enzyme | Ki | 4.96 | CHEMBL | |||||
UDP-glucuronosyltransferase 1-10 | Enzyme | Ki | 4.55 | CHEMBL | |||||
Transient receptor potential cation channel subfamily M member 3 | Ion channel | BLOCKER | IC50 | 5.20 | IUPHAR | ||||
Fatty acid-binding protein, liver | Unclassified | Ki | 5.49 | CHEMBL | |||||
Prostaglandin G/H synthase 2 | Enzyme | IC50 | 7.66 | CHEMBL | |||||
Prostaglandin G/H synthase 1 | Enzyme | IC50 | 7.17 | CHEMBL | |||||
Prostaglandin G/H synthase 2 | Enzyme | IC50 | 7.22 | CHEMBL | |||||
Prostaglandin G/H synthase 1 | Enzyme | IC50 | 8.52 | CHEMBL |
ID | Source |
---|---|
4019714 | VUID |
N0000147806 | NUI |
D00903 | KEGG_DRUG |
88170-10-9 | SECONDARY_CAS_RN |
78213-16-8 | SECONDARY_CAS_RN |
15307-79-6 | SECONDARY_CAS_RN |
15307-81-0 | SECONDARY_CAS_RN |
119623-66-4 | SECONDARY_CAS_RN |
203214 | RXNORM |
4019378 | VANDF |
4019714 | VANDF |
4020829 | VANDF |
4027248 | VANDF |
C0012091 | UMLSCUI |
CHEBI:47381 | CHEBI |
DIF | PDB_CHEM_ID |
CHEMBL139 | ChEMBL_ID |
CHEMBL1034 | ChEMBL_ID |
DB00586 | DRUGBANK_ID |
CHEMBL1200804 | ChEMBL_ID |
CHEMBL1201180 | ChEMBL_ID |
D004008 | MESH_DESCRIPTOR_UI |
C000614065 | MESH_SUPPLEMENTAL_RECORD_UI |
C064142 | MESH_SUPPLEMENTAL_RECORD_UI |
3033 | PUBCHEM_CID |
2714 | IUPHAR_LIGAND_ID |
3270 | INN_ID |
144O8QL0L1 | UNII |
11838 | MMSL |
23373 | MMSL |
3184 | MMSL |
340620 | MMSL |
37364 | MMSL |
4582 | MMSL |
4583 | MMSL |
4584 | MMSL |
d00848 | MMSL |
002391 | NDDF |
004409 | NDDF |
004410 | NDDF |
005170 | NDDF |
006237 | NDDF |
108515008 | SNOMEDCT_US |
363598004 | SNOMEDCT_US |
425650004 | SNOMEDCT_US |
426714006 | SNOMEDCT_US |
62039007 | SNOMEDCT_US |
7034005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
ARTHROTEC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0025-1411 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 33 sections |
ARTHROTEC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0025-1411 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 33 sections |
ARTHROTEC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0025-1421 | TABLET, FILM COATED | 75 mg | ORAL | NDA | 33 sections |
ARTHROTEC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0025-1421 | TABLET, FILM COATED | 75 mg | ORAL | NDA | 33 sections |
VoltarenArthritis Pain | HUMAN OTC DRUG LABEL | 1 | 0067-8152 | GEL | 10 mg | TOPICAL | NDA | 18 sections |
VOLTAREN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0478 | SOLUTION | 1 mg | OPHTHALMIC | NDA | 16 sections |
Diclofenac Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0948 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 14 sections |
Diclofenac Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0948 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 14 sections |
diclofenac epolamine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3225 | PATCH | 0.01 g | TOPICAL | NDA authorized generic | 30 sections |
diclofenac epolamine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3727 | SYSTEM | 0.01 g | TOPICAL | NDA authorized generic | 31 sections |
diclofenac epolamine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3727 | SYSTEM | 0.01 g | TOPICAL | NDA authorized generic | 31 sections |
good sense arthritis pain | HUMAN OTC DRUG LABEL | 1 | 0113-1189 | GEL | 10 mg | TOPICAL | ANDA | 17 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1483 | GEL | 30 mg | TOPICAL | ANDA | 15 sections |
DICLOFENAC SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0803 | GEL | 30 mg | TOPICAL | NDA authorized generic | 27 sections |
DICLOFENAC SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0844 | GEL | 30 mg | TOPICAL | NDA authorized generic | 27 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2550 | TABLET, DELAYED RELEASE | 50 mg | ORAL | ANDA | 26 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2550 | TABLET, DELAYED RELEASE | 50 mg | ORAL | ANDA | 26 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2551 | TABLET, DELAYED RELEASE | 75 mg | ORAL | ANDA | 26 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2551 | TABLET, DELAYED RELEASE | 75 mg | ORAL | ANDA | 26 sections |
Aleve Arthritis Pain Gel | HUMAN OTC DRUG LABEL | 1 | 0280-0039 | GEL | 1 mg | TOPICAL | ANDA | 17 sections |
Aleve Arthritis Pain Gel | HUMAN OTC DRUG LABEL | 1 | 0280-0039 | GEL | 1 mg | TOPICAL | ANDA | 17 sections |
Diclofenac sodium | HUMAN OTC DRUG LABEL | 1 | 0363-1210 | GEL | 10 mg | TOPICAL | ANDA | 17 sections |
diclofenac sodium | HUMAN OTC DRUG LABEL | 1 | 0363-1871 | GEL | 10 mg | TOPICAL | ANDA | 17 sections |
Diclofenac Sodium Topical Gel 1% | Human OTC Drug Label | 1 | 0363-7065 | GEL | 10 mg | TOPICAL | ANDA | 15 sections |
Diclofenac Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2474 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 26 sections |
Diclofenac Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2474 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 26 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-8750 | GEL | 10 mg | TOPICAL | ANDA | 28 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0472-1783 | GEL | 30 mg | TOPICAL | ANDA | 25 sections |
Diclofenac potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0480-9435 | CAPSULE, LIQUID FILLED | 25 mg | ORAL | ANDA | 23 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2170 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 13 sections |