diclofenac 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibufenac derivatives 865 15307-86-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • diclofenac calcium
  • diclofenac diethylamine
  • diclofenac hydroxyethylpyrrolidine
  • diclofenac
  • diclofenamic acid
  • diclofenac sodium
  • diclofenac potassium
  • diclofenac epolamine
A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
  • Molecular weight: 296.15
  • Formula: C14H11Cl2NO2
  • CLOGP: 4.58
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 49.33
  • ALOGS: -4.82
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O
0.10 g P
0.10 g R
0.10 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 10.85 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.00 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0.50 % Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 55 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.40 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,GRK2,IKBKB,ITK,MAP2K6,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,STK33,TEK,TGFBR1 33
kinase-selectivity-class ACVR2B,AXL,BRAF,CDK9,GRK2,MAP2K6,MAPK7,PDK4 8
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
rat-kpuu-brain Rat brain Kpuu 0.074 % High 1

Approvals:

DateAgencyCompanyOrphan
March 23, 2021 PMDA Hisamitsu Pharmaceutical Co., Inc
July 28, 1988 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 2391.24 10.44 5911 565503 320953 89736080
Glossodynia 2267.43 10.44 5737 565677 316042 89740991
Systemic lupus erythematosus 2164.34 10.44 6071 565343 355825 89701208
Rheumatoid arthritis 2106.87 10.44 6020 565394 356594 89700439
Hand deformity 2019.02 10.44 5218 566196 291144 89765889
Wound 1851.12 10.44 5124 566290 297856 89759177
Pericarditis 1807.23 10.44 4725 566689 265426 89791607
Anti-cyclic citrullinated peptide antibody positive 1568.24 10.44 4123 567291 232310 89824723
Arthropathy 1440.51 10.44 5324 566090 360918 89696115
Duodenal ulcer perforation 1440.03 10.44 3832 567582 217456 89839577
Discomfort 1422.56 10.44 4377 567037 269958 89787075
Abdominal discomfort 1385.20 10.44 6316 565098 471012 89586021
Synovitis 1352.56 10.44 4860 566554 324892 89732141
Helicobacter infection 1335.55 10.44 3787 567627 223063 89833970
Swelling 1197.22 10.44 5521 565893 413537 89643496
Alopecia 1084.68 10.44 6053 565361 489018 89568015
Contraindicated product administered 1083.73 10.44 4440 566974 315699 89741334
Hepatic enzyme increased 1070.34 10.44 4807 566607 355929 89701104
Folliculitis 998.17 10.44 3195 568219 201158 89855875
Death 966.31 10.44 874 570540 455677 89601356
Infusion related reaction 951.28 10.44 5154 566260 411626 89645407
Rheumatic fever 886.60 10.44 2542 568872 150579 89906454
Muscle injury 886.37 10.44 2788 568626 173866 89883167
Irritable bowel syndrome 871.19 10.44 3083 568331 204365 89852668
Psoriatic arthropathy 860.21 10.44 3276 568138 225059 89831974
Rheumatoid factor positive 848.32 10.44 2695 568719 168955 89888078
Maternal exposure during pregnancy 841.16 10.44 4482 566932 355581 89701452
Type 2 diabetes mellitus 791.12 10.44 2947 568467 200297 89856736
Joint swelling 788.67 10.44 5651 565763 497649 89559384
Blister 781.17 10.44 3432 567982 251566 89805467
Impaired healing 757.19 10.44 3204 568210 230995 89826038
Neutropenia 728.41 10.44 254 571160 224650 89832383
Embolia cutis medicamentosa 719.11 10.44 234 571180 409 90056624
Hypersensitivity 706.16 10.44 5095 566319 449582 89607451
Product use issue 690.29 10.44 3987 567427 325932 89731101
Toxicity to various agents 680.90 10.44 493 570921 287353 89769680
Cough 665.89 10.44 808 570606 368154 89688879
Swollen joint count increased 656.95 10.44 1860 569554 109346 89947687
Liver injury 654.28 10.44 2462 568952 168105 89888928
Febrile neutropenia 637.70 10.44 114 571300 158235 89898798
Sleep disorder due to general medical condition, insomnia type 613.28 10.44 1996 569418 126698 89930335
Blood cholesterol increased 601.71 10.44 2753 568661 205259 89851774
Product dose omission issue 595.80 10.44 576 570838 291111 89765922
Hypotension 585.57 10.44 714 570700 324683 89732350
Drug intolerance 578.22 10.44 4806 566608 442785 89614248
Injury 567.15 10.44 2607 568807 194742 89862291
Fibromyalgia 554.89 10.44 2673 568741 203596 89853437
Treatment failure 545.10 10.44 3530 567884 300398 89756635
Musculoskeletal stiffness 527.43 10.44 3437 567977 293095 89763938
Anaemia 508.87 10.44 903 570511 351899 89705134
Joint range of motion decreased 504.44 10.44 1939 569475 133704 89923329
Nausea 501.56 10.44 4536 566878 1105780 88951253
Completed suicide 479.67 10.44 158 571256 144900 89912133
Grip strength decreased 471.21 10.44 1469 569945 91107 89965926
Ill-defined disorder 463.05 10.44 2348 569066 182543 89874490
Facet joint syndrome 458.78 10.44 1515 569899 96874 89960159
Lip dry 449.04 10.44 1530 569884 99425 89957608
Constipation 443.07 10.44 676 570738 279719 89777314
Diarrhoea 443.02 10.44 3793 567621 935397 89121636
Stomatitis 440.59 10.44 3104 568310 271594 89785439
Therapeutic product effect decreased 432.72 10.44 3115 568299 274456 89782577
Disease progression 427.24 10.44 227 571187 156388 89900645
Lower respiratory tract infection 424.79 10.44 2871 568543 247788 89809245
Urinary tract infection 419.57 10.44 806 570608 304826 89752207
Gastrointestinal disorder 412.49 10.44 2902 568512 253785 89803248
General physical health deterioration 408.02 10.44 3717 567697 351398 89705635
Bursitis 387.55 10.44 1752 569662 129902 89927131
Wound infection 387.35 10.44 1511 569903 104891 89952142
Fall 370.88 10.44 1669 569745 480141 89576892
Seizure 363.82 10.44 259 571155 152370 89904663
Prescribed overdose 363.23 10.44 1396 570018 96229 89960804
Sleep disorder 361.39 10.44 2311 569103 195719 89861314
Osteoarthritis 360.18 10.44 2289 569125 193441 89863592
COVID-19 358.01 10.44 322 571092 168521 89888512
Dehydration 351.30 10.44 425 570989 194022 89863011
Mobility decreased 351.20 10.44 2744 568670 247990 89809043
White blood cell count decreased 343.32 10.44 328 571086 166781 89890252
Pancytopenia 340.41 10.44 166 571248 120097 89936936
Peripheral venous disease 332.06 10.44 1224 570190 82697 89974336
Gait inability 323.53 10.44 1797 569617 144659 89912374
Hypercholesterolaemia 321.47 10.44 1375 570039 99517 89957516
Sepsis 320.62 10.44 397 571017 179417 89877616
Cardiac failure congestive 320.15 10.44 111 571303 98583 89958450
Breast cancer stage III 316.14 10.44 1210 570204 83237 89973796
Platelet count decreased 314.07 10.44 242 571172 136727 89920306
Electrocardiogram QT prolonged 305.38 10.44 46 571368 72410 89984623
Atrial fibrillation 303.91 10.44 238 571176 133373 89923660
Neuropathy peripheral 302.78 10.44 251 571163 136719 89920314
Deep vein thrombosis postoperative 299.90 10.44 1056 570358 69753 89987280
Intentional product use issue 299.45 10.44 2366 569048 214526 89842507
Hip arthroplasty 294.40 10.44 1103 570311 75105 89981928
Injection site pain 285.72 10.44 407 571007 173292 89883741
Malignant neoplasm progression 285.45 10.44 159 571255 106711 89950322
Cerebrovascular accident 277.25 10.44 223 571191 123310 89933723
Pneumonia 263.35 10.44 2662 568752 635397 89421636
Dislocation of vertebra 260.98 10.44 862 570552 55106 90001927
Autoimmune disorder 260.94 10.44 1067 570347 75677 89981356
Live birth 253.44 10.44 1080 570334 78027 89979006
Rash 253.05 10.44 6687 564727 789413 89267620
Thrombocytopenia 251.55 10.44 592 570822 208133 89848900
Knee arthroplasty 251.50 10.44 1116 570298 82066 89974967
Pain 249.20 10.44 8121 563293 988220 89068813
Obesity 246.04 10.44 1314 570100 104193 89952840
Blood pressure increased 245.23 10.44 550 570864 196667 89860366
Cardiac arrest 244.92 10.44 182 571232 104753 89952280
Cardiac failure 242.80 10.44 200 571214 109296 89947737
Road traffic accident 237.25 10.44 1320 570094 106306 89950727
Chest discomfort 236.79 10.44 315 571099 138050 89918983
Adjustment disorder with depressed mood 235.70 10.44 841 570573 55912 90001121
Infection 234.27 10.44 3390 568024 358704 89698329
Drug interaction 233.83 10.44 923 570491 275530 89781503
Myelosuppression 232.92 10.44 31 571383 53560 90003473
Lower limb fracture 232.16 10.44 1107 570307 83906 89973127
Heart rate increased 231.39 10.44 222 571192 112680 89944353
Hypokalaemia 230.02 10.44 293 571121 130823 89926210
Respiratory failure 226.62 10.44 247 571167 118171 89938862
Retinitis 224.74 10.44 641 570773 37817 90019216
Pulmonary embolism 223.68 10.44 298 571116 130522 89926511
Night sweats 222.74 10.44 1483 569931 127283 89929750
Neutrophil count decreased 222.61 10.44 86 571328 71446 89985587
Lupus vulgaris 221.84 10.44 707 570707 44352 90012681
Acute kidney injury 220.60 10.44 1154 570260 319233 89737800
Device expulsion 218.65 10.44 9 571405 40877 90016156
Hypoaesthesia 218.63 10.44 2980 568434 311230 89745803
Contusion 217.00 10.44 2481 568933 248735 89808298
Sciatica 215.25 10.44 1231 570183 100151 89956882
Balance disorder 214.41 10.44 178 571236 96902 89960131
Chills 214.31 10.44 312 571102 131669 89925364
Off label use 214.22 10.44 5306 566108 1096946 88960087
Hypoxia 214.05 10.44 94 571320 72305 89984728
Pleural effusion 207.31 10.44 240 571174 111751 89945282
Influenza 200.01 10.44 357 571057 138907 89918126
Somnolence 198.60 10.44 665 570749 208419 89848614
Dyspnoea 197.68 10.44 4146 567268 876809 89180224
Dry mouth 196.70 10.44 1898 569516 182161 89874872
Nail disorder 196.66 10.44 816 570598 58251 89998782
Dry skin 195.10 10.44 161 571253 87912 89969121
Oxygen saturation decreased 195.03 10.44 234 571180 107249 89949784
Blood glucose increased 189.73 10.44 192 571222 95054 89961979
Deafness transitory 185.74 10.44 131 571283 1912 90055121
Hypoglycaemia 182.10 10.44 107 571307 69741 89987292
Pulmonary fibrosis 179.85 10.44 1228 570186 106275 89950758
Epistaxis 179.59 10.44 163 571251 84962 89972071
Feeling abnormal 179.39 10.44 503 570911 166732 89890301
Wheezing 177.99 10.44 2288 569126 235792 89821241
Palpitations 176.80 10.44 373 571041 136355 89920678
Bradycardia 176.36 10.44 161 571253 83686 89973347
X-ray abnormal 174.20 10.44 656 570758 44768 90012265
Injection site erythema 171.85 10.44 221 571193 98281 89958752
Myocardial infarction 170.58 10.44 252 571162 105720 89951313
Leukopenia 170.54 10.44 231 571183 100479 89956554
Erythema 169.59 10.44 805 570609 228441 89828592
Cognitive disorder 169.02 10.44 115 571299 69292 89987741
Syncope 168.96 10.44 365 571049 132298 89924735
C-reactive protein abnormal 168.06 10.44 1376 570038 126053 89930980
Ankylosing spondylitis 167.75 10.44 299 571115 12834 90044199
Coma 165.61 10.44 129 571285 72503 89984530
Prescribed underdose 164.57 10.44 919 570495 74100 89982933
Inappropriate schedule of product administration 164.51 10.44 446 570968 149487 89907546
Incorrect dose administered 163.12 10.44 154 571260 78776 89978257
Mucosal inflammation 162.34 10.44 80 571334 57545 89999488
Liver disorder 161.28 10.44 1312 570102 119957 89937076
Cardio-respiratory arrest 158.65 10.44 101 571313 63039 89993994
Tremor 158.21 10.44 469 570945 152704 89904329
Confusional state 157.97 10.44 3361 568053 382844 89674189
Product label confusion 154.64 10.44 402 571012 22448 90034585
Vision blurred 153.67 10.44 288 571126 110005 89947028
Onychomadesis 153.55 10.44 636 570778 45362 90011671
Musculoskeletal pain 153.55 10.44 1704 569710 169547 89887486
Lung disorder 153.47 10.44 1532 569882 148351 89908682
Neoplasm progression 153.19 10.44 45 571369 44441 90012592
Urticaria 152.88 10.44 2796 568618 309938 89747095
Flushing 152.86 10.44 200 571214 88291 89968742
Nasopharyngitis 151.99 10.44 3497 567917 403607 89653426
Peripheral swelling 151.60 10.44 3540 567874 409566 89647467
Macular degeneration 151.35 10.44 28 571386 37942 90019091
Laryngitis 151.17 10.44 678 570736 50075 90006958
Blepharospasm 150.64 10.44 721 570693 54724 90002309
Hyponatraemia 150.47 10.44 392 571022 133146 89923887
Haemoglobin decreased 147.75 10.44 524 570890 161432 89895601
Drug abuse 147.56 10.44 181 571233 82166 89974867
Nasal congestion 146.70 10.44 186 571228 83228 89973805
Chronic obstructive pulmonary disease 144.58 10.44 151 571263 73678 89983355
Dysphagia 143.73 10.44 308 571106 111970 89945063
Back injury 142.02 10.44 627 570787 45995 90011038
Deep vein thrombosis 141.57 10.44 224 571190 91396 89965637
Multiple sclerosis relapse 139.39 10.44 78 571336 52227 90004806
Pulmonary oedema 139.34 10.44 112 571302 61968 89995065
Plasma cell myeloma 139.31 10.44 42 571372 40786 90016247
Septic shock 135.58 10.44 200 571214 83960 89973073
Rhinorrhoea 135.44 10.44 217 571197 88099 89968934
Exostosis 135.09 10.44 678 570736 52456 90004577
Back pain 134.79 10.44 1313 570101 315862 89741171
Lupus-like syndrome 134.74 10.44 638 570776 48208 90008825
Weight increased 134.70 10.44 3519 567895 414408 89642625
Renal failure 134.66 10.44 402 571012 130605 89926428
Sedation 134.00 10.44 68 571346 48103 90008930
Mental status changes 133.67 10.44 57 571357 44622 90012411
Wrong technique in product usage process 132.85 10.44 153 571261 71418 89985615
Bone erosion 132.31 10.44 673 570741 52348 90004685
C-reactive protein 132.09 10.44 467 570947 30900 90026133
Clostridium difficile infection 131.70 10.44 33 571381 36212 90020821
Joint dislocation 131.61 10.44 594 570820 43988 90013045
Coeliac disease 130.67 10.44 593 570821 44017 90013016
Lethargy 129.52 10.44 124 571290 63015 89994018
Inflammation 129.09 10.44 1706 569708 176886 89880147
Abdominal pain 126.61 10.44 1745 569669 393976 89663057
Influenza like illness 126.53 10.44 195 571219 80416 89976617
Ear infection 125.71 10.44 812 570602 68963 89988070
Cellulitis 125.04 10.44 241 571173 91096 89965937
Myalgia 124.83 10.44 623 570791 174502 89882531
Pneumonia aspiration 124.46 10.44 51 571363 40889 90016144
Anti-cyclic citrullinated peptide antibody 123.10 10.44 415 570999 26806 90030227
Hyperglycaemia 122.05 10.44 86 571328 50884 90006149
Dyspnoea exertional 121.18 10.44 167 571247 72121 89984912
Adverse event 119.61 10.44 1199 570215 116219 89940814
Agitation 118.63 10.44 149 571265 66949 89990084
Depressed level of consciousness 118.19 10.44 172 571242 72612 89984421
Unevaluable event 118.12 10.44 103 571311 54745 90002288
Posterior reversible encephalopathy syndrome 115.93 10.44 6 571408 22333 90034700
Adverse reaction 115.50 10.44 431 570983 29281 90027752
Cardiac disorder 115.14 10.44 113 571301 56759 90000274
Cytokine release syndrome 115.06 10.44 19 571395 27954 90029079
Pulmonary arterial hypertension 114.15 10.44 15 571399 26172 90030861
Ascites 113.72 10.44 81 571333 47659 90009374
Full blood count abnormal 112.22 10.44 45 571369 36552 90020481
Renal impairment 110.14 10.44 321 571093 105100 89951933
Cytomegalovirus infection 109.57 10.44 18 571396 26584 90030449
Procedural pain 109.06 10.44 37 571377 33323 90023710
Device dislocation 108.12 10.44 32 571382 31450 90025583
Herpes zoster 108.01 10.44 276 571138 94368 89962665
Hallucination 107.95 10.44 155 571259 65804 89991229
Abortion spontaneous 105.35 10.44 111 571303 53945 90003088
Dyspepsia 105.06 10.44 1795 569619 196365 89860668
Suicidal ideation 104.51 10.44 191 571223 73664 89983369
Drug resistance 104.48 10.44 31 571383 30418 90026615
Oropharyngeal pain 104.16 10.44 374 571040 114813 89942220
Hypomagnesaemia 103.94 10.44 47 571367 35541 90021492
Blood potassium decreased 103.54 10.44 89 571325 47638 90009395
Accidental exposure to product 103.41 10.44 70 571344 42296 90014737
Injection site pruritus 103.29 10.44 112 571302 53722 90003311
Skin exfoliation 103.07 10.44 168 571246 67745 89989288
C-reactive protein increased 102.76 10.44 1661 569753 179728 89877305
Respiratory distress 102.45 10.44 59 571355 38887 90018146
Blood creatinine increased 102.11 10.44 314 571100 101072 89955961
Premature delivery 101.57 10.44 59 571355 38703 90018330
Sinus disorder 101.38 10.44 45 571369 34402 90022631
Alanine aminotransferase increased 100.65 10.44 394 571020 117944 89939089
Injection site swelling 100.54 10.44 138 571276 59701 89997332
Injection site bruising 100.16 10.44 109 571305 52198 90004835
Productive cough 99.79 10.44 210 571204 76853 89980180
Metastases to liver 99.44 10.44 29 571385 28778 90028255
Swelling face 99.33 10.44 229 571185 81123 89975910
Seronegative arthritis 98.93 10.44 296 571118 17938 90039095
Thrombosis 98.78 10.44 195 571219 73056 89983977
Breast cancer stage II 98.53 10.44 463 570951 34871 90022162
Finger deformity 98.36 10.44 440 570974 32457 90024576
Intentional overdose 97.09 10.44 287 571127 93547 89963486
Therapy interrupted 96.41 10.44 104 571310 50004 90007029
Drug ineffective for unapproved indication 96.41 10.44 170 571244 66474 89990559
Gastric ulcer perforation 96.23 10.44 75 571339 1285 90055748
Oedema 95.78 10.44 1785 569629 198510 89858523
Oral candidiasis 95.74 10.44 52 571362 35403 90021630
Taste disorder 95.27 10.44 690 570724 60856 89996177
Intestinal obstruction 95.21 10.44 58 571356 37073 90019960
Hypervolaemia 94.52 10.44 44 571370 32713 90024320
Acute myeloid leukaemia 94.49 10.44 10 571404 20630 90036403
Onychomycosis 94.36 10.44 476 570938 36900 90020133
Hypertension 94.07 10.44 3650 567764 453882 89603151
Hepatotoxicity 94.06 10.44 90 571324 45752 90011281
Intestinal diaphragm disease 93.48 10.44 36 571378 125 90056908
Delirium 93.30 10.44 1038 570376 103321 89953712
Generalised tonic-clonic seizure 93.07 10.44 52 571362 34851 90022182
Colitis 92.76 10.44 188 571226 69754 89987279
Maternal exposure timing unspecified 92.33 10.44 332 571082 22151 90034882
Multiple organ dysfunction syndrome 92.07 10.44 182 571232 68154 89988879
Encephalopathy 92.05 10.44 94 571320 46350 90010683
Orthostatic hypotension 91.96 10.44 77 571337 41750 90015283
Aspartate aminotransferase increased 91.90 10.44 336 571078 102601 89954432
Unresponsive to stimuli 91.69 10.44 64 571350 38057 90018976
Exposure during pregnancy 90.09 10.44 2052 569362 236358 89820675
Liver function test abnormal 89.79 10.44 113 571301 50732 90006301
Chronic sinusitis 89.78 10.44 20 571394 23782 90033251
Neurotoxicity 89.60 10.44 14 571400 21453 90035580
Dysphonia 89.39 10.44 163 571251 62921 89994112
No adverse event 89.08 10.44 184 571230 67798 89989235
Bone marrow failure 88.85 10.44 46 571368 32175 90024858
Stress 88.60 10.44 243 571171 81152 89975881
Complication associated with device 87.57 10.44 10 571404 19439 90037594
Loss of consciousness 86.69 10.44 523 570891 139715 89917318
Sedation complication 86.53 10.44 5 571409 16939 90040094
Dysarthria 86.26 10.44 131 571283 54351 90002682
Throat irritation 86.22 10.44 108 571306 48587 90008446
Hospitalisation 85.49 10.44 466 570948 127634 89929399
Hepatic cytolysis 85.46 10.44 44 571370 30872 90026161
Rhabdomyolysis 85.32 10.44 119 571295 51137 90005896
Ventricular tachycardia 85.06 10.44 25 571389 24683 90032350
Tachycardia 84.87 10.44 613 570801 157060 89899973
Porphyria acute 84.80 10.44 278 571136 17697 90039336
Foot deformity 84.55 10.44 655 570759 58996 89998037
Sinusitis 84.24 10.44 2793 568621 340295 89716738
Cataract 83.99 10.44 208 571206 71884 89985149
Urosepsis 83.89 10.44 16 571398 21216 90035817
Blood calcium decreased 83.36 10.44 43 571371 30139 90026894
Device issue 83.20 10.44 41 571373 29496 90027537
Depressed mood 83.20 10.44 117 571297 50105 90006928
Headache 82.72 10.44 4523 566891 858223 89198810
Psychotic disorder 82.59 10.44 47 571367 31183 90025850
Disease recurrence 81.94 10.44 70 571344 37583 90019450
Hypercalcaemia 81.68 10.44 58 571356 34182 90022851
Bronchitis 81.61 10.44 596 570818 152331 89904702
Neoplasm malignant 81.33 10.44 57 571357 33823 90023210
Therapy cessation 81.10 10.44 66 571348 36295 90020738
Vomiting 80.96 10.44 4104 567310 784189 89272844
Female genital tract fistula 80.92 10.44 9 571405 17859 90039174
Acute respiratory failure 80.46 10.44 91 571323 42827 90014206
Bacteraemia 79.69 10.44 21 571393 22279 90034754
Migraine 79.66 10.44 1663 569751 188729 89868304
Hepatic cirrhosis 79.61 10.44 676 570738 62577 89994456
Pericardial effusion 79.52 10.44 69 571345 36764 90020269
Status epilepticus 79.48 10.44 12 571402 18862 90038171
Blood pressure fluctuation 79.22 10.44 130 571284 52283 90004750
Lymphocyte count decreased 78.95 10.44 63 571351 34987 90022046
Aphasia 78.93 10.44 92 571322 42720 90014313
Metabolic acidosis 78.76 10.44 144 571270 55532 90001501
Bone pain 78.51 10.44 171 571243 61812 89995221
Dysgeusia 77.92 10.44 132 571282 52428 90004605
Respiratory tract congestion 77.28 10.44 38 571376 27372 90029661
Diabetic ketoacidosis 76.50 10.44 29 571385 24378 90032655
Proctitis 76.43 10.44 5 571409 15254 90041779
Vaginal discharge 76.20 10.44 15 571399 19449 90037584
Haemoptysis 76.18 10.44 59 571355 33261 90023772
Hot flush 75.44 10.44 164 571250 59324 89997709
Joint stiffness 75.21 10.44 788 570626 77254 89979779
Ejection fraction decreased 74.62 10.44 36 571378 26217 90030816
Osteonecrosis of jaw 74.30 10.44 82 571332 39021 90018012
Obstructive airways disorder 74.25 10.44 35 571379 25834 90031199
Haematochezia 74.01 10.44 216 571198 70697 89986336
Thrombotic microangiopathy 73.71 10.44 7 571407 15736 90041297
Cystitis 73.50 10.44 198 571216 66520 89990513
Diabetes mellitus 73.39 10.44 190 571224 64685 89992348
Walking aid user 73.28 10.44 428 570986 35078 90021955
Liver function test increased 73.13 10.44 838 570576 84017 89973016
Treatment noncompliance 72.98 10.44 134 571280 51593 90005440
Asthenia 72.76 10.44 2692 568722 531059 89525974
Neuroleptic malignant syndrome 72.60 10.44 6 571408 15090 90041943
Blood bilirubin increased 72.28 10.44 101 571313 43369 90013664
Fungal infection 72.06 10.44 98 571316 42563 90014470
Epilepsy 71.82 10.44 814 570600 81392 89975641
Cerebral haemorrhage 71.74 10.44 67 571347 34455 90022578
Lung neoplasm malignant 70.98 10.44 32 571382 24241 90032792
Arrhythmia 69.74 10.44 99 571315 42233 90014800
Skin ulcer 69.52 10.44 131 571283 49944 90007089
Extrapyramidal disorder 69.50 10.44 10 571404 16293 90040740
Clostridium difficile colitis 69.48 10.44 41 571373 26665 90030368
Eye pruritus 69.46 10.44 49 571365 28978 90028055
Aggression 69.30 10.44 41 571373 26627 90030406
Cytopenia 69.26 10.44 13 571401 17436 90039597
Pneumonitis 69.17 10.44 107 571307 44063 90012970
Blood test abnormal 68.91 10.44 23 571391 20929 90036104
Hepatic failure 68.39 10.44 90 571324 39638 90017395
Drug dependence 68.23 10.44 51 571363 29276 90027757
Red blood cell count decreased 68.17 10.44 117 571297 46234 90010799
Torsade de pointes 67.87 10.44 8 571406 15174 90041859
Respiratory tract infection 67.62 10.44 172 571242 58906 89998127
Feeling cold 67.54 10.44 45 571369 27420 90029613
Breast cancer 66.71 10.44 150 571264 53611 90003422
Memory impairment 66.68 10.44 1672 569742 195572 89861461
Candida infection 66.29 10.44 70 571344 33987 90023046
Haemorrhage 66.24 10.44 220 571194 69149 89987884
Palmar-plantar erythrodysaesthesia syndrome 66.15 10.44 48 571366 27975 90029058
Oral pain 66.09 10.44 65 571349 32618 90024415
Full blood count decreased 66.08 10.44 54 571360 29635 90027398
Skin discolouration 65.96 10.44 111 571303 44204 90012829
Abnormal behaviour 65.90 10.44 30 571384 22598 90034435
Hypocalcaemia 65.05 10.44 104 571310 42264 90014769
Vertigo 64.89 10.44 224 571190 69587 89987446
Sensory loss 64.63 10.44 17 571397 18058 90038975
Basal cell carcinoma 64.57 10.44 69 571345 33320 90023713
Coordination abnormal 64.28 10.44 27 571387 21329 90035704
Ulcer haemorrhage 64.20 10.44 332 571082 25989 90031044
Anxiety 64.18 10.44 1475 569939 308297 89748736
Cholestasis 63.75 10.44 81 571333 36218 90020815
Metastases to central nervous system 63.68 10.44 16 571398 17526 90039507
Progressive multifocal leukoencephalopathy 63.58 10.44 11 571403 15644 90041389
Transfusion 63.39 10.44 16 571398 17472 90039561
Cardiac murmur 63.38 10.44 18 571396 18176 90038857
Heavy menstrual bleeding 63.34 10.44 25 571389 20505 90036528
Right ventricular failure 63.31 10.44 21 571393 19184 90037849
Haematotoxicity 63.10 10.44 4 571410 12531 90044502
Therapy partial responder 63.00 10.44 30 571384 22013 90035020
Weight decreased 62.60 10.44 1870 569544 378040 89678993
Product storage error 61.88 10.44 25 571389 20216 90036817
Lacrimation increased 61.76 10.44 48 571366 27014 90030019
Injection site mass 61.71 10.44 31 571383 22059 90034974
Motor dysfunction 61.71 10.44 22 571392 19208 90037825
Chronic kidney disease 61.50 10.44 141 571273 50050 90006983
Radiculopathy 61.41 10.44 20 571394 18485 90038548
Hemiparesis 61.26 10.44 66 571348 31753 90025280
Abdominal pain upper 60.95 10.44 2622 568792 330052 89726981
Subcutaneous drug absorption impaired 60.80 10.44 206 571208 13339 90043694
Pulmonary hypertension 60.13 10.44 110 571304 42413 90014620
Dyskinesia 59.64 10.44 86 571328 36448 90020585
Electrolyte imbalance 59.62 10.44 38 571376 23707 90033326
Haematocrit decreased 59.34 10.44 108 571306 41724 90015309
Interstitial lung disease 59.00 10.44 264 571150 76141 89980892
Transplant rejection 58.87 10.44 6 571408 12752 90044281
Pulmonary mass 58.43 10.44 57 571357 28715 90028318
Dysuria 58.36 10.44 99 571315 39302 90017731
Hypothyroidism 58.27 10.44 158 571256 52969 90004064
International normalised ratio increased 57.91 10.44 133 571281 47183 90009850
Ischaemic stroke 57.71 10.44 34 571380 22132 90034901
Injection site haemorrhage 57.63 10.44 56 571358 28262 90028771
Atelectasis 57.37 10.44 42 571372 24367 90032666
Urinary incontinence 56.93 10.44 93 571321 37473 90019560
Blood glucose decreased 56.79 10.44 39 571375 23390 90033643
Gastric ulcer 56.73 10.44 331 571083 27117 90029916
Transient ischaemic attack 56.45 10.44 117 571297 43059 90013974
Hemiplegia 56.28 10.44 16 571398 16144 90040889
Nasal polyps 56.21 10.44 3 571411 10877 90046156
Neutropenic sepsis 56.06 10.44 22 571392 18108 90038925
Burning sensation 56.05 10.44 208 571206 63244 89993789
Tonsillar ulcer 55.89 10.44 31 571383 287 90056746
Arthralgia 55.86 10.44 5664 565750 772858 89284175
Bronchiectasis 55.71 10.44 36 571378 22294 90034739
Transaminases increased 55.50 10.44 93 571321 37099 90019934
Schizophrenia 55.32 10.44 13 571401 14901 90042132
Paraesthesia oral 55.23 10.44 71 571343 31588 90025445
Creatinine renal clearance decreased 55.13 10.44 25 571389 18874 90038159
Foetal exposure during pregnancy 54.89 10.44 118 571296 42857 90014176
Drug-induced liver injury 54.88 10.44 837 570577 89481 89967552
Device related infection 54.82 10.44 49 571365 25737 90031296
Disturbance in attention 54.81 10.44 136 571278 46973 90010060
Sopor 54.63 10.44 45 571369 24599 90032434
Eczema 54.48 10.44 162 571252 52708 90004325
Haemophagocytic lymphohistiocytosis 54.40 10.44 15 571399 15444 90041589
Suicide attempt 54.40 10.44 267 571147 75132 89981901
Oligohydramnios 54.28 10.44 132 571282 7069 90049964
Drug tolerance decreased 54.28 10.44 368 571046 31762 90025271
Bacterial infection 54.25 10.44 41 571373 23403 90033630
Diabetes mellitus inadequate control 54.06 10.44 25 571389 18659 90038374
Cholelithiasis 54.02 10.44 161 571253 52345 90004688
Ataxia 54.00 10.44 23 571391 18019 90039014
Metastases to bone 53.59 10.44 49 571365 25456 90031577
Acute respiratory distress syndrome 53.58 10.44 61 571353 28625 90028408
Viral infection 53.49 10.44 113 571301 41301 90015732
Second primary malignancy 53.19 10.44 3 571411 10375 90046658
Diverticulitis 52.93 10.44 130 571284 45057 90011976
Hip fracture 52.88 10.44 79 571335 32998 90024035
Panniculitis 52.84 10.44 13 571401 14445 90042588
Respiratory arrest 52.83 10.44 80 571334 33231 90023802
Akathisia 52.14 10.44 5 571409 11154 90045879
Femur fracture 52.09 10.44 135 571279 45947 90011086
Small intestinal obstruction 51.93 10.44 35 571379 21199 90035834
Vascular device infection 51.73 10.44 7 571407 11945 90045088
Hyperhidrosis 51.02 10.44 581 570833 135724 89921309
Agranulocytosis 50.88 10.44 89 571325 34913 90022120
Sinus congestion 50.48 10.44 59 571355 27365 90029668
Injection site rash 50.13 10.44 47 571367 24126 90032907
Serotonin syndrome 50.10 10.44 102 571312 37785 90019248
Pancreatitis acute 50.09 10.44 78 571336 32037 90024996
Arterial occlusive disease 49.99 10.44 9 571405 12437 90044596
Dementia 49.95 10.44 46 571368 23815 90033218
Product quality issue 49.70 10.44 739 570675 78586 89978447
Tachypnoea 49.65 10.44 37 571377 21272 90035761
Shoulder arthroplasty 49.59 10.44 92 571322 4074 90052959
Breast cancer female 49.56 10.44 16 571398 14870 90042163
Flatulence 49.25 10.44 118 571296 41249 90015784
Impaired quality of life 49.18 10.44 44 571370 23100 90033933
Adjustment disorder 48.77 10.44 3 571411 9639 90047394
Gestational diabetes 48.77 10.44 5 571409 10577 90046456
Rash macular 48.72 10.44 72 571342 30208 90026825
Eye pain 48.71 10.44 131 571283 44037 90012996
Drug level increased 48.70 10.44 62 571352 27700 90029333
Device difficult to use 48.35 10.44 25 571389 17500 90039533
Gastrointestinal pain 48.18 10.44 168 571246 11038 90045995
Tinnitus 48.17 10.44 127 571287 42975 90014058
Bone disorder 47.89 10.44 45 571369 23075 90033958
Skin fissures 47.37 10.44 37 571377 20772 90036261
Dry eye 47.27 10.44 196 571218 57735 89999298
Tooth disorder 47.09 10.44 77 571337 31013 90026020
Infective pulmonary exacerbation of cystic fibrosis 47.00 10.44 5 571409 10274 90046759
Ductus arteriosus stenosis foetal 46.93 10.44 25 571389 212 90056821
Renal failure neonatal 46.75 10.44 24 571390 187 90056846
Acne 46.63 10.44 67 571347 28440 90028593
Dystonia 46.39 10.44 24 571390 16795 90040238
Crying 46.32 10.44 56 571358 25589 90031444
Rhinitis allergic 46.23 10.44 24 571390 16761 90040272
Sneezing 46.15 10.44 73 571341 29796 90027237
Nervous system disorder 45.95 10.44 41 571373 21552 90035481
Blood pressure abnormal 45.91 10.44 34 571380 19611 90037422
Blood calcium increased 45.75 10.44 10 571404 12048 90044985
Lymphopenia 45.70 10.44 46 571368 22835 90034198
Drug withdrawal syndrome 45.53 10.44 69 571345 28654 90028379
Drug ineffective 45.45 10.44 7859 563555 1376439 88680594
Kidney infection 45.34 10.44 58 571356 25858 90031175
Brain oedema 44.79 10.44 27 571387 17358 90039675
Oral herpes 44.54 10.44 90 571324 33434 90023599
Pharyngitis 44.28 10.44 263 571151 21684 90035349
Sputum discoloured 44.26 10.44 38 571376 20353 90036680
Multiple allergies 44.23 10.44 20 571394 15126 90041907
Bronchopulmonary aspergillosis 44.17 10.44 9 571405 11389 90045644
Gallbladder disorder 44.09 10.44 36 571378 19767 90037266
Proteinuria 44.08 10.44 49 571365 23242 90033791
Pregnancy 44.08 10.44 591 570823 61456 89995577
Disability 43.88 10.44 421 570993 40324 90016709
Cardiomyopathy 43.44 10.44 38 571376 20168 90036865
Nephrolithiasis 43.29 10.44 161 571253 48924 90008109
Complication of device insertion 43.12 10.44 7 571407 10429 90046604
Aspergillus infection 43.09 10.44 8 571406 10815 90046218
Localised infection 42.99 10.44 92 571322 33470 90023563
Eye irritation 42.81 10.44 94 571320 33884 90023149
Heart rate irregular 42.78 10.44 54 571360 24214 90032819
Haemorrhage intracranial 42.77 10.44 21 571393 15141 90041892
Breast cancer metastatic 42.63 10.44 21 571393 15111 90041922
Thyroid disorder 42.59 10.44 30 571384 17755 90039278
Pneumothorax 42.48 10.44 35 571379 19132 90037901
Small intestine ulcer 42.31 10.44 28 571386 366 90056667
Psychomotor hyperactivity 42.25 10.44 14 571400 12799 90044234
Multiple sclerosis 42.12 10.44 69 571345 27771 90029262
Neck pain 42.11 10.44 978 570436 112985 89944048
Pain in jaw 41.92 10.44 158 571256 47827 90009206
Spondylitis 41.91 10.44 189 571225 13989 90043044
Hyperkalaemia 41.87 10.44 239 571175 64725 89992308
Blood pressure systolic increased 41.86 10.44 207 571207 58138 89998895
Duodenal ulcer 41.76 10.44 144 571270 9408 90047625
Infusion site reaction 41.58 10.44 233 571181 18806 90038227
Cardiogenic shock 41.53 10.44 56 571358 24412 90032621
Infusion site pain 41.38 10.44 38 571376 19700 90037333
Subdural haematoma 41.30 10.44 27 571387 16618 90040415
Device occlusion 41.23 10.44 5 571409 9277 90047756
Renal disorder 41.21 10.44 113 571301 37746 90019287
Paranoia 41.02 10.44 15 571399 12893 90044140
Spinal fracture 40.92 10.44 47 571367 21969 90035064
Breath sounds abnormal 40.91 10.44 23 571391 15363 90041670
Presyncope 40.89 10.44 87 571327 31718 90025315
Therapy change 40.89 10.44 3 571411 8319 90048714
Diplopia 40.85 10.44 74 571340 28640 90028393
Skin haemorrhage 40.44 10.44 45 571369 21335 90035698
Device breakage 40.31 10.44 19 571395 14025 90043008
Pre-eclampsia 40.25 10.44 10 571404 11038 90045995
Emotional distress 40.23 10.44 109 571305 36553 90020480
Upper limb fracture 40.18 10.44 46 571368 21532 90035501
Illness 40.17 10.44 327 571087 81642 89975391
Immunosuppression 40.17 10.44 13 571401 12064 90044969
Staphylococcal infection 40.08 10.44 163 571251 48276 90008757
Fear 39.85 10.44 28 571386 16594 90040439
Anosmia 39.82 10.44 7 571407 9841 90047192
Jejunal ulcer 39.80 10.44 18 571396 102 90056931
Red blood cell sedimentation rate increased 39.76 10.44 737 570677 81858 89975175
Amnesia 39.73 10.44 930 570484 107575 89949458
Incorrect route of product administration 39.66 10.44 491 570923 50135 90006898
Gout 39.63 10.44 29 571385 16830 90040203
Blood pressure decreased 39.41 10.44 293 571121 74602 89982431
Disorientation 39.36 10.44 144 571270 43970 90013063
Mania 39.19 10.44 20 571394 14104 90042929
Myocarditis 39.13 10.44 19 571395 13787 90043246
Vaginal haemorrhage 39.00 10.44 87 571327 31184 90025849
Mental impairment 39.00 10.44 29 571385 16691 90040342
Exposure to toxic agent 38.78 10.44 3 571411 7964 90049069
Head injury 38.71 10.44 87 571327 31101 90025932
Caesarean section 38.66 10.44 36 571378 18541 90038492
Injection site urticaria 38.56 10.44 34 571380 17977 90039056
Fistula 38.50 10.44 14 571400 12075 90044958
Polyneuropathy 38.49 10.44 39 571375 19302 90037731
Enterococcal infection 38.49 10.44 8 571406 9983 90047050
Irritability 38.40 10.44 107 571307 35555 90021478
Epstein-Barr virus infection 38.40 10.44 9 571405 10335 90046698
Amenorrhoea 38.32 10.44 13 571401 11709 90045324
Upper-airway cough syndrome 38.30 10.44 24 571390 15111 90041922
Sleep apnoea syndrome 38.24 10.44 90 571324 31657 90025376
Melaena 38.19 10.44 361 571053 34436 90022597
Sacroiliitis 38.05 10.44 83 571331 4136 90052897
Adverse drug reaction 37.87 10.44 984 570430 115717 89941316
Pustular psoriasis 37.85 10.44 223 571191 18333 90038700
Coagulopathy 37.84 10.44 55 571359 23234 90033799
Nervousness 37.56 10.44 101 571313 33955 90023078
Altered state of consciousness 37.49 10.44 90 571324 31442 90025591
Parkinsonism 37.43 10.44 21 571393 14044 90042989
Ulcer 37.42 10.44 96 571318 32786 90024247
Large intestinal stenosis 37.37 10.44 61 571353 2436 90054597
Blindness 37.32 10.44 69 571345 26499 90030534
Bedridden 37.14 10.44 15 571399 12133 90044900
Drug level decreased 37.05 10.44 8 571406 9722 90047311
Angina pectoris 36.83 10.44 125 571289 39035 90017998
Speech disorder 36.72 10.44 155 571259 45430 90011603
Restless legs syndrome 36.57 10.44 53 571361 22417 90034616
Dermatitis 36.57 10.44 52 571362 22168 90034865
Metastases to lymph nodes 36.45 10.44 14 571400 11675 90045358
Hypogammaglobulinaemia 36.38 10.44 11 571403 10663 90046370
Pollakiuria 36.31 10.44 98 571316 32907 90024126
Sinus bradycardia 36.30 10.44 32 571382 16920 90040113
Rash pruritic 36.28 10.44 337 571077 81877 89975156
Failure to thrive 36.23 10.44 5 571409 8406 90048627
Product substitution issue 36.20 10.44 36 571378 17972 90039061
Insurance issue 36.09 10.44 12 571402 10946 90046087
Gangrene 36.07 10.44 18 571396 12858 90044175
Joint injury 35.93 10.44 97 571317 32567 90024466
Toothache 35.63 10.44 53 571361 22177 90034856
Hyperthyroidism 35.22 10.44 38 571376 18272 90038761
General symptom 35.07 10.44 184 571230 14484 90042549
Gastrointestinal procedural complication 35.02 10.44 27 571387 455 90056578
Eye injury 34.92 10.44 150 571264 10870 90046163
Panic attack 34.84 10.44 71 571343 26294 90030739
Sickle cell anaemia with crisis 34.82 10.44 3 571411 7294 90049739
COVID-19 pneumonia 34.66 10.44 38 571376 18139 90038894
Device malfunction 34.61 10.44 49 571365 20928 90036105
Mood swings 34.51 10.44 48 571366 20654 90036379
Acute myocardial infarction 34.45 10.44 109 571305 34781 90022252
Peripheral sensory neuropathy 34.43 10.44 8 571406 9242 90047791
Heart rate decreased 34.40 10.44 197 571217 53308 90003725
Device use error 34.37 10.44 3 571411 7218 90049815
Eosinophilia 34.28 10.44 81 571333 28452 90028581
Affect lability 34.18 10.44 38 571376 18025 90039008
Rash vesicular 34.14 10.44 214 571200 17983 90039050
Malnutrition 34.08 10.44 40 571374 18518 90038515
Fracture 34.07 10.44 54 571360 22022 90035011
Foot fracture 34.02 10.44 73 571341 26533 90030500
Hypoaesthesia oral 33.94 10.44 29 571385 15571 90041462
Intentional self-injury 33.88 10.44 85 571329 29249 90027784
Muscle twitching 33.87 10.44 63 571351 24139 90032894
Glycosylated haemoglobin increased 33.78 10.44 29 571385 15533 90041500
Carpal tunnel syndrome 33.74 10.44 62 571352 23866 90033167
Uterine perforation 33.72 10.44 4 571410 7550 90049483
Ductus arteriosus premature closure 33.56 10.44 25 571389 399 90056634
Haemorrhoids 33.54 10.44 74 571340 26628 90030405
Genital haemorrhage 33.46 10.44 7 571407 8695 90048338
Myoclonus 33.42 10.44 43 571371 19125 90037908
Sinus tachycardia 33.41 10.44 82 571332 28431 90028602
Skin infection 33.35 10.44 38 571376 17826 90039207
Staphylococcal bacteraemia 33.23 10.44 4 571410 7465 90049568
Blood pressure diastolic decreased 33.15 10.44 75 571339 26751 90030282
Diffuse large B-cell lymphoma 33.14 10.44 7 571407 8638 90048395
Lymphadenopathy 33.07 10.44 162 571252 45613 90011420
Glaucoma 32.76 10.44 50 571364 20705 90036328
Hypomania 32.52 10.44 8 571406 8889 90048144
Gastric disorder 32.47 10.44 105 571309 33279 90023754
Hypovolaemia 32.46 10.44 19 571395 12412 90044621
Ocular hyperaemia 32.39 10.44 107 571307 33691 90023342
Condition aggravated 32.39 10.44 4257 567157 591288 89465745
Drug dose omission by device 32.33 10.44 12 571402 10219 90046814
Tongue disorder 32.25 10.44 14 571400 10846 90046187
Functional gastrointestinal disorder 32.16 10.44 87 571327 4975 90052058
Skin cancer 32.11 10.44 23 571391 13496 90043537
Metastases to lung 32.10 10.44 32 571382 15959 90041074
Encephalitis 32.05 10.44 15 571399 11119 90045914
Seasonal allergy 32.01 10.44 60 571354 22923 90034110
Hypersomnia 31.98 10.44 54 571360 21477 90035556
Poisoning deliberate 31.95 10.44 34 571380 16452 90040581
Hypoacusis 31.93 10.44 81 571333 27769 90029264
Blood sodium decreased 31.90 10.44 80 571334 27533 90029500
Mental disorder 31.89 10.44 101 571313 32217 90024816
Hypophosphataemia 31.85 10.44 28 571386 14826 90042207
Unintended pregnancy 31.83 10.44 5 571409 7632 90049401
Surgery 31.78 10.44 160 571254 44727 90012306
Central nervous system lesion 31.56 10.44 17 571397 11629 90045404
Cushingoid 31.51 10.44 13 571401 10382 90046651
Rales 31.40 10.44 32 571382 15795 90041238
Pain of skin 31.36 10.44 33 571381 16049 90040984
Abortion induced 31.28 10.44 18 571396 11870 90045163
Dermatitis atopic 31.19 10.44 63 571351 23409 90033624
Product administration error 30.96 10.44 76 571338 26347 90030686
Myopathy 30.82 10.44 24 571390 13494 90043539
Tumour lysis syndrome 30.63 10.44 16 571398 11136 90045897
Pelvic pain 30.52 10.44 31 571383 15326 90041707
Myelodysplastic syndrome 30.52 10.44 53 571361 20850 90036183
Red blood cell sedimentation rate abnormal 30.46 10.44 67 571347 24137 90032896
Skin laceration 30.41 10.44 75 571339 25960 90031073
Mood altered 30.37 10.44 38 571376 17106 90039927
Hypothermia 30.32 10.44 32 571382 15543 90041490
Restlessness 30.31 10.44 119 571295 35601 90021432
Gastrointestinal toxicity 30.09 10.44 11 571403 9456 90047577
Endoscopy abnormal 29.99 10.44 9 571405 10 90057023
Product dose omission in error 29.92 10.44 52 571362 20451 90036582
Body temperature decreased 29.91 10.44 66 571348 23750 90033283
Hypertensive crisis 29.88 10.44 41 571373 17743 90039290
Salivary hypersecretion 29.87 10.44 10 571404 9082 90047951
Lactic acidosis 29.72 10.44 191 571223 50272 90006761
Rebound effect 29.66 10.44 11 571403 9373 90047660
Hepatic encephalopathy 29.48 10.44 26 571388 13746 90043287
Ventricular fibrillation 29.48 10.44 27 571387 14017 90043016
Cardiomegaly 29.48 10.44 46 571368 18879 90038154
Subarachnoid haemorrhage 29.36 10.44 42 571372 17862 90039171
Visual acuity reduced 29.30 10.44 65 571349 23345 90033688
Pyrexia 29.29 10.44 3682 567732 656803 89400230
Product preparation error 29.27 10.44 14 571400 10247 90046786
Eye infection 29.22 10.44 28 571386 14226 90042807
Exercise tolerance decreased 29.18 10.44 6 571408 7545 90049488
Grip strength 29.16 10.44 123 571291 8842 90048191
Thinking abnormal 29.15 10.44 19 571395 11713 90045320
Pulseless electrical activity 29.03 10.44 10 571404 8922 90048111
Needle issue 29.00 10.44 27 571387 13907 90043126
Metabolic disorder 28.74 10.44 6 571408 7464 90049569
Haemolysis 28.59 10.44 9 571405 8501 90048532
Swollen tongue 28.59 10.44 171 571243 45785 90011248
Aspirin-exacerbated respiratory disease 28.49 10.44 28 571386 662 90056371
Appetite disorder 28.38 10.44 11 571403 9122 90047911
Urine abnormality 28.19 10.44 7 571407 7730 90049303
Gastrointestinal erosion 28.16 10.44 29 571385 726 90056307
Nasal oedema 28.16 10.44 4 571410 6580 90050453
Accidental overdose 28.15 10.44 88 571326 28185 90028848
Tardive dyskinesia 28.12 10.44 17 571397 10913 90046120
Electrocardiogram QRS complex prolonged 28.07 10.44 6 571408 7342 90049691
Toxic skin eruption 27.91 10.44 35 571379 15739 90041294
Hyperbilirubinaemia 27.85 10.44 28 571386 13908 90043125
Foetal methotrexate syndrome 27.83 10.44 14 571400 104 90056929
Toxic encephalopathy 27.83 10.44 10 571404 8689 90048344
Pelvic fracture 27.74 10.44 33 571381 15186 90041847
Anal incontinence 27.69 10.44 37 571377 16193 90040840
Partial seizures 27.58 10.44 6 571408 7254 90049779
Hyperammonaemia 27.53 10.44 4 571410 6471 90050562
Drug eruption 27.53 10.44 122 571292 35285 90021748
Delusion 27.44 10.44 28 571386 13812 90043221
Duodenal ulcer haemorrhage 27.41 10.44 54 571360 2502 90054531
Suspected suicide 27.38 10.44 13 571401 9555 90047478
Pharyngitis streptococcal 27.35 10.44 24 571390 12718 90044315
Granulocytopenia 27.34 10.44 4 571410 6437 90050596
Feeling jittery 27.30 10.44 34 571380 15337 90041696
Leukocytosis 27.10 10.44 102 571312 30888 90026145
Emotional disorder 26.82 10.44 33 571381 14964 90042069
Hyperlipidaemia 26.78 10.44 66 571348 22850 90034183
Coronary artery disease 26.67 10.44 115 571299 33508 90023525
Device leakage 26.47 10.44 15 571399 9976 90047057
Fat necrosis 26.47 10.44 28 571386 724 90056309
Eosinophil count increased 26.46 10.44 26 571388 13055 90043978
Lymphoma 26.38 10.44 28 571386 13563 90043470
Complication of device removal 26.29 10.44 4 571410 6251 90050782
Hypocholesterolaemia 26.28 10.44 95 571319 6354 90050679
Immune reconstitution inflammatory syndrome 26.27 10.44 6 571408 7013 90050020
Multiple drug therapy 26.21 10.44 6 571408 7003 90050030
Limb discomfort 26.19 10.44 137 571277 37923 90019110
Rheumatoid nodule 26.06 10.44 55 571359 20111 90036922
Euglycaemic diabetic ketoacidosis 25.98 10.44 4 571410 6197 90050836
Malaise 25.93 10.44 3267 568147 582719 89474314
Paradoxical drug reaction 25.87 10.44 3 571411 5763 90051270
Medication error 25.80 10.44 708 570706 83944 89973089
Infusion site erythema 25.60 10.44 29 571385 13641 90043392
Large intestinal ulcer 25.57 10.44 68 571346 3849 90053184
Sarcoidosis 25.56 10.44 18 571396 10655 90046378
Pulmonary thrombosis 25.47 10.44 15 571399 9767 90047266
Pneumocystis jirovecii pneumonia 25.46 10.44 62 571352 21554 90035479
Lower respiratory tract infection viral 25.38 10.44 31 571383 941 90056092
Swollen joint count 25.31 10.44 115 571299 8538 90048495
Wrist fracture 25.28 10.44 37 571377 15587 90041446
Pneumonia viral 25.23 10.44 12 571402 8811 90048222
Catheter site infection 25.22 10.44 3 571411 5651 90051382
Pneumonia bacterial 25.21 10.44 26 571388 12764 90044269
Catatonia 25.16 10.44 4 571410 6052 90050981
White blood cell count abnormal 25.10 10.44 8 571406 7496 90049537
Periorbital oedema 25.08 10.44 97 571317 6702 90050331
Troponin increased 25.07 10.44 28 571386 13253 90043780
Cardiac failure acute 24.96 10.44 23 571391 11906 90045127
Ventricular extrasystoles 24.94 10.44 28 571386 13222 90043811
Overdose 24.77 10.44 781 570633 156928 89900105
Hernia 24.74 10.44 32 571382 14199 90042834
Muscle tightness 24.64 10.44 29 571385 13410 90043623
Premature labour 24.38 10.44 29 571385 13347 90043686
Therapeutic response shortened 24.37 10.44 69 571345 22810 90034223
Congestive cardiomyopathy 24.31 10.44 8 571406 7346 90049687
Pseudomonas infection 24.25 10.44 35 571379 14830 90042203
Atrioventricular block complete 24.22 10.44 16 571398 9795 90047238
Product prescribing issue 24.15 10.44 10 571404 7969 90049064
Acute graft versus host disease 24.15 10.44 3 571411 5465 90051568
Neutrophil count increased 24.13 10.44 54 571360 19336 90037697
Respiratory depression 24.13 10.44 38 571376 15537 90041496
Escherichia urinary tract infection 24.08 10.44 31 571383 13784 90043249
Wrist deformity 24.03 10.44 59 571355 3179 90053854
Type I hypersensitivity 24.02 10.44 69 571345 4086 90052947
Lung infiltration 23.94 10.44 37 571377 15245 90041788
Blood alkaline phosphatase increased 23.92 10.44 191 571223 47888 90009145
Haematoma 23.92 10.44 146 571268 38902 90018131
Osteonecrosis 23.84 10.44 85 571329 26156 90030877
Poor venous access 23.80 10.44 55 571359 19472 90037561
Anger 23.70 10.44 31 571383 13689 90043344
Atrioventricular block first degree 23.69 10.44 12 571402 8499 90048534
Lymphatic fistula 23.66 10.44 37 571377 1424 90055609
Aspiration 23.64 10.44 39 571375 15654 90041379
Splenomegaly 23.58 10.44 28 571386 12896 90044137
Immune effector cell-associated neurotoxicity syndrome 23.54 10.44 4 571410 5764 90051269
Respiratory syncytial virus infection 23.40 10.44 19 571395 10461 90046572
Injection site warmth 23.29 10.44 47 571367 17468 90039565
Ageusia 23.25 10.44 41 571373 16035 90040998
Anal abscess 23.20 10.44 4 571410 5704 90051329
Mass 23.20 10.44 39 571375 15538 90041495
Choking 23.12 10.44 25 571389 12008 90045025
Bone lesion 23.12 10.44 6 571408 6431 90050602
Skin toxicity 23.08 10.44 7 571407 6772 90050261
Body temperature increased 23.00 10.44 176 571238 44534 90012499
Skin mass 23.00 10.44 9 571405 7421 90049612
Infusion site swelling 22.91 10.44 24 571390 11696 90045337
Femoral hernia incarcerated 22.78 10.44 37 571377 1471 90055562
Pulmonary haemorrhage 22.75 10.44 11 571403 8002 90049031
Blood magnesium decreased 22.72 10.44 40 571374 15653 90041380
Miosis 22.71 10.44 16 571398 9468 90047565
Complications of intestinal transplant 22.69 10.44 8 571406 20 90057013
Immune system disorder 22.58 10.44 25 571389 11880 90045153
Aortic stenosis 22.58 10.44 6 571408 6330 90050703
Ovarian cyst 22.58 10.44 47 571367 17271 90039762
Rhinovirus infection 22.51 10.44 5 571409 5958 90051075
Respiration abnormal 22.51 10.44 11 571403 7952 90049081
Dizziness 22.43 10.44 3316 568098 585968 89471065
Hospice care 22.41 10.44 17 571397 9687 90047346
Renal cancer 22.41 10.44 5 571409 5940 90051093
Atrioventricular block 22.28 10.44 14 571400 8801 90048232
Stress cardiomyopathy 22.23 10.44 31 571383 13324 90043709
Atrial flutter 22.21 10.44 21 571393 10737 90046296
Rhinitis 22.10 10.44 32 571382 13540 90043493
Pleuritic pain 22.09 10.44 20 571394 10441 90046592
Muscle rigidity 22.08 10.44 35 571379 14274 90042759
Hepatic function abnormal 22.07 10.44 186 571228 46102 90010931
Myositis 22.01 10.44 241 571173 23887 90033146
Central pain syndrome 21.92 10.44 24 571390 646 90056387
Neonatal intestinal perforation 21.89 10.44 8 571406 23 90057010
Therapeutic product effect incomplete 21.85 10.44 999 570415 192897 89864136
Faeces soft 21.81 10.44 10 571404 7501 90049532
Blood potassium increased 21.79 10.44 63 571351 20686 90036347
Renal function test abnormal 21.79 10.44 9 571405 7182 90049851
Granuloma 21.77 10.44 6 571408 6179 90050854
Cholecystitis chronic 21.71 10.44 18 571396 9808 90047225
Abdominal rebound tenderness 21.64 10.44 8 571406 24 90057009
Alanine aminotransferase abnormal 21.63 10.44 4 571410 5422 90051611
Skin disorder 21.58 10.44 139 571275 36567 90020466
Injection site necrosis 21.56 10.44 36 571378 1465 90055568
Blood glucose abnormal 21.45 10.44 17 571397 9475 90047558
Embolism 21.40 10.44 17 571397 9464 90047569
Amniotic cavity disorder 21.25 10.44 10 571404 63 90056970
Facial paralysis 21.24 10.44 41 571373 15493 90041540
Paronychia 21.24 10.44 12 571402 7994 90049039
Systemic candida 21.24 10.44 3 571411 4956 90052077
Ventricular hypokinesia 21.15 10.44 4 571410 5337 90051696
Bladder disorder 21.12 10.44 22 571392 10750 90046283
Gastroenteritis viral 21.03 10.44 109 571305 30246 90026787
Blood creatine phosphokinase increased 20.95 10.44 127 571287 33896 90023137
Hereditary angioedema 20.88 10.44 17 571397 9348 90047685
Pulmonary alveolar haemorrhage 20.77 10.44 6 571408 5992 90051041
Cholecystitis 20.77 10.44 48 571366 16992 90040041
Mucous stools 20.77 10.44 4 571410 5267 90051766
Cardiac tamponade 20.71 10.44 5 571409 5627 90051406
SARS-CoV-2 test positive 20.42 10.44 24 571390 11104 90045929
Pulmonary congestion 20.41 10.44 59 571355 19374 90037659
Spinal fusion surgery 20.34 10.44 140 571274 12143 90044890
Vasculitis 20.29 10.44 74 571340 22619 90034414
Hallucination, auditory 20.29 10.44 44 571370 15931 90041102
Jaundice cholestatic 20.27 10.44 20 571394 10023 90047010
Skin burning sensation 20.27 10.44 60 571354 19551 90037482
Klebsiella infection 20.22 10.44 21 571393 10276 90046757
Hallucinations, mixed 20.20 10.44 6 571408 5883 90051150
Cystitis haemorrhagic 20.07 10.44 5 571409 5508 90051525
Injection site scab 20.03 10.44 23 571391 653 90056380
Myasthenia gravis 19.95 10.44 9 571405 6816 90050217
Generalised oedema 19.90 10.44 58 571356 18995 90038038
Abnormal dreams 19.89 10.44 25 571389 11232 90045801
Post procedural complication 19.87 10.44 58 571356 18984 90038049
Mitral valve incompetence 19.78 10.44 74 571340 22450 90034583
Bradykinesia 19.77 10.44 9 571405 6779 90050254
Synostosis 19.76 10.44 9 571405 52 90056981
Premature baby 19.75 10.44 86 571328 24991 90032042
Menstrual disorder 19.73 10.44 7 571407 6131 90050902
Gingivitis 19.68 10.44 18 571396 9351 90047682
Incontinence 19.67 10.44 34 571380 13401 90043632
Glomerular filtration rate decreased 19.60 10.44 49 571365 16883 90040150
Rotator cuff repair 19.59 10.44 46 571368 2408 90054625
Lung opacity 19.55 10.44 7 571407 6095 90050938
Nodule 19.54 10.44 94 571320 26592 90030441
Hepatic enzyme 19.52 10.44 76 571338 5268 90051765
Food allergy 19.48 10.44 246 571168 25232 90031801
Pneumonia fungal 19.44 10.44 10 571404 7021 90050012
Drug reaction with eosinophilia and systemic symptoms 19.41 10.44 174 571240 42584 90014449
Dissociation 19.40 10.44 9 571405 6706 90050327
Therapy non-responder 19.40 10.44 1051 570363 135653 89921380
Anal fissure 19.38 10.44 5 571409 5380 90051653
Multiple fractures 19.35 10.44 19 571395 9543 90047490
Injection site extravasation 19.34 10.44 17 571397 9002 90048031
Left ventricular failure 19.33 10.44 9 571405 6691 90050342
Specific gravity urine abnormal 19.26 10.44 10 571404 80 90056953
Poisoning 19.25 10.44 42 571372 15175 90041858
Tooth infection 19.23 10.44 64 571350 20106 90036927
Pancreatic steatosis 19.22 10.44 36 571378 1606 90055427
Pancreatitis 19.15 10.44 317 571097 69509 89987524
Neonatal respiratory acidosis 19.15 10.44 15 571399 259 90056774
Supraventricular tachycardia 19.13 10.44 47 571367 16289 90040744
Head discomfort 19.12 10.44 47 571367 16286 90040747
Carotid artery occlusion 19.12 10.44 8 571406 6334 90050699
Blood triglycerides increased 19.10 10.44 36 571378 13725 90043308
Vitreous floaters 19.06 10.44 12 571402 7537 90049496
Respiratory acidosis 19.04 10.44 14 571400 8105 90048928
Apathy 19.01 10.44 25 571389 11015 90046018
Product dispensing error 18.96 10.44 30 571384 12243 90044790
Rib fracture 18.84 10.44 94 571320 26341 90030692
Menstruation irregular 18.77 10.44 14 571400 8046 90048987
Injection site induration 18.76 10.44 23 571391 10445 90046588
Injection site discomfort 18.71 10.44 7 571407 5933 90051100
Throat tightness 18.71 10.44 109 571305 29375 90027658
Cachexia 18.70 10.44 10 571404 6868 90050165
Intestinal ulcer 18.65 10.44 36 571378 1643 90055390
Pulmonary function test decreased 18.60 10.44 3 571411 4491 90052542
Photophobia 18.60 10.44 70 571344 21199 90035834
Emphysema 18.50 10.44 30 571384 12125 90044908
Blood urine present 18.49 10.44 52 571362 17226 90039807
Injection site nodule 18.48 10.44 3 571411 4470 90052563
Premature rupture of membranes 18.46 10.44 6 571408 5552 90051481
Hypoalbuminaemia 18.41 10.44 46 571368 15851 90041182
Eye discharge 18.40 10.44 15 571399 8243 90048790
Loss of personal independence in daily activities 18.36 10.44 687 570727 135418 89921615
Fear of injection 18.32 10.44 16 571398 8499 90048534
Lipase increased 18.29 10.44 26 571388 11085 90045948
Ovarian germ cell teratoma benign 18.25 10.44 12 571402 155 90056878
Spinal stenosis 18.25 10.44 179 571235 17245 90039788
Sinus headache 18.22 10.44 9 571405 6467 90050566
Gastrooesophageal reflux disease 18.22 10.44 1250 570164 165087 89891946
Thirst 18.22 10.44 48 571366 16247 90040786
Bronchospasm 18.21 10.44 68 571346 20641 90036392
Breast cancer recurrent 18.17 10.44 6 571408 5497 90051536
Left ventricular hypertrophy 18.12 10.44 8 571406 6136 90050897
Blood pressure systolic decreased 18.10 10.44 19 571395 9251 90047782
Metastasis 18.09 10.44 8 571406 6129 90050904
Osteopenia 18.04 10.44 79 571335 22923 90034110
Tumour marker increased 18.03 10.44 7 571407 5800 90051233
Hydrocephalus 17.87 10.44 8 571406 6086 90050947
Facial pain 17.85 10.44 35 571379 13147 90043886
Inappropriate antidiuretic hormone secretion 17.84 10.44 63 571351 19442 90037591
Vitamin D decreased 17.83 10.44 30 571384 11949 90045084
Platelet count abnormal 17.70 10.44 3 571411 4332 90052701
Haemolytic anaemia 17.68 10.44 29 571385 11668 90045365
Flank pain 17.64 10.44 62 571352 19160 90037873
Clostridium test positive 17.64 10.44 6 571408 5395 90051638
Ovulation disorder 17.62 10.44 7 571407 27 90057006
Soft tissue injury 17.57 10.44 40 571374 2052 90054981
Tension headache 17.54 10.44 13 571401 7496 90049537
Diverticulum 17.42 10.44 31 571383 12082 90044951
Jaw clicking 17.38 10.44 10 571404 100 90056933
Product administered to patient of inappropriate age 17.37 10.44 4 571410 4649 90052384
Urinary tract infection bacterial 17.29 10.44 9 571405 6276 90050757
Leukaemia 17.28 10.44 5 571409 4987 90052046
Ileal ulcer 17.27 10.44 27 571387 1039 90055994
Heparin-induced thrombocytopenia 17.18 10.44 6 571408 5306 90051727
Scleroderma 17.17 10.44 9 571405 6252 90050781
Orthopnoea 17.08 10.44 11 571403 6824 90050209
Gallbladder adenocarcinoma 17.05 10.44 10 571404 104 90056929
Circulatory collapse 16.93 10.44 90 571324 24814 90032219
Femur-fibula-ulna complex 16.93 10.44 5 571409 5 90057028
Catheter site pain 16.88 10.44 7 571407 5572 90051461
Muscle tone disorder 16.87 10.44 11 571403 140 90056893
Intermenstrual bleeding 16.81 10.44 20 571394 9203 90047830
Drooling 16.79 10.44 4 571410 4542 90052491
Bradyphrenia 16.75 10.44 14 571400 7598 90049435
Bundle branch block left 16.74 10.44 15 571399 7870 90049163
Personality change 16.69 10.44 13 571401 7308 90049725
Hepatomegaly 16.68 10.44 37 571377 13289 90043744
Therapeutic response unexpected 16.65 10.44 76 571338 21804 90035229
Impaired work ability 16.64 10.44 64 571350 19262 90037771
Sleep disorder due to general medical condition, hypersomnia type 16.63 10.44 39 571375 2040 90054993
Eye inflammation 16.59 10.44 15 571399 7836 90049197
Pathogen resistance 16.57 10.44 16 571398 8099 90048934
Malignant melanoma 16.50 10.44 34 571380 12542 90044491
Cholecystitis acute 16.50 10.44 21 571393 9383 90047650
Activated partial thromboplastin time prolonged 16.48 10.44 15 571399 7810 90049223
Product complaint 16.48 10.44 38 571376 13462 90043571
Eye disorder 16.47 10.44 103 571311 27287 90029746
Bladder cancer 16.42 10.44 8 571406 5793 90051240
Aphthous ulcer 16.38 10.44 55 571359 17232 90039801
Extra dose administered 16.37 10.44 20 571394 9098 90047935
Hysterectomy 16.35 10.44 30 571384 11554 90045479
Hepatocellular injury 16.35 10.44 111 571303 28847 90028186
Urine porphobilinogen increased 16.29 10.44 4 571410 0 90057033
Atrioventricular block second degree 16.28 10.44 4 571410 4448 90052585
Wound infection pseudomonas 16.24 10.44 38 571376 1985 90055048
Retinal haemorrhage 16.24 10.44 8 571406 5756 90051277
Embolic stroke 16.23 10.44 3 571411 4069 90052964
Initial insomnia 16.12 10.44 21 571393 9289 90047744
Muscular weakness 16.11 10.44 1513 569901 205153 89851880
Withdrawal syndrome 16.11 10.44 80 571334 22444 90034589
Cholecystectomy 16.10 10.44 31 571383 11724 90045309
Escherichia bacteraemia 16.09 10.44 8 571406 5727 90051306
Glucose tolerance impaired 16.01 10.44 16 571398 7969 90049064
Paralysis 15.95 10.44 30 571384 11448 90045585
Thyroid neoplasm 15.95 10.44 3 571411 4018 90053015
Brain natriuretic peptide increased 15.93 10.44 9 571405 5996 90051037
Temperature regulation disorder 15.87 10.44 151 571263 14428 90042605
Syringe issue 15.85 10.44 3 571411 3999 90053034
Oral discomfort 15.84 10.44 26 571388 10457 90046576
Arteriospasm coronary 15.83 10.44 6 571408 5044 90051989
Anti-neutrophil cytoplasmic antibody positive vasculitis 15.80 10.44 3 571411 3990 90053043
Back disorder 15.74 10.44 238 571176 25393 90031640
Portal hypertension 15.74 10.44 5 571409 4696 90052337
Hepatitis C 15.72 10.44 8 571406 5652 90051381
Osteoporosis 15.72 10.44 752 570662 95779 89961254
Vaccination site reaction 15.69 10.44 13 571401 244 90056789
Hepatitis B reactivation 15.69 10.44 3 571411 3971 90053062
Herpes simplex 15.62 10.44 25 571389 10156 90046877
Hypertriglyceridaemia 15.59 10.44 16 571398 7873 90049160
Breast pain 15.59 10.44 26 571388 10392 90046641
Oesophagitis 15.59 10.44 56 571358 17193 90039840
Optic neuritis 15.58 10.44 23 571391 9655 90047378
Ventricular arrhythmia 15.57 10.44 4 571410 4317 90052716
Gastroenteritis 15.54 10.44 114 571300 29115 90027918
Pseudomonal sepsis 15.47 10.44 4 571410 4298 90052735
Lip swelling 15.47 10.44 162 571252 38448 90018585
Eye movement disorder 15.45 10.44 10 571404 6188 90050845
Urinoma 15.43 10.44 7 571407 40 90056993
Ketoacidosis 15.41 10.44 8 571406 5587 90051446
Soft tissue disorder 15.40 10.44 4 571410 4286 90052747
Hallucination, visual 15.40 10.44 84 571330 23008 90034025
Libido increased 15.38 10.44 34 571380 1710 90055323
Metabolic encephalopathy 15.38 10.44 12 571402 6740 90050293
Squamous cell carcinoma 15.31 10.44 25 571389 10076 90046957
Arteriovenous fistula occlusion 15.21 10.44 15 571399 356 90056677
Meralgia paraesthetica 15.19 10.44 18 571396 529 90056504
Haemodynamic instability 15.18 10.44 32 571382 11707 90045326
Embedded device 15.18 10.44 4 571410 4244 90052789
Protein urine present 15.18 10.44 13 571401 6971 90050062
Cross sensitivity reaction 15.14 10.44 46 571368 2811 90054222
Application site rash 15.12 10.44 44 571370 2625 90054408
Coronary artery occlusion 15.11 10.44 19 571395 8535 90048498
Rash maculo-papular 15.10 10.44 175 571239 40758 90016275
Osteomyelitis 15.10 10.44 108 571306 27738 90029295
Post procedural haemorrhage 15.07 10.44 20 571394 8778 90048255
Major depression 15.06 10.44 25 571389 10010 90047023
Lymphocyte stimulation test positive 15.05 10.44 17 571397 474 90056559
Nystagmus 15.05 10.44 14 571400 7213 90049820
Immobile 15.05 10.44 11 571403 6387 90050646
Escherichia sepsis 15.03 10.44 9 571405 5807 90051226
Pruritus genital 15.00 10.44 5 571409 4553 90052480
Carbuncle 14.99 10.44 30 571384 1406 90055627
Blood lactic acid increased 14.99 10.44 20 571394 8758 90048275
Gastritis erosive 14.97 10.44 83 571331 6672 90050361
Blindness unilateral 14.94 10.44 16 571398 7720 90049313
Eyelid ptosis 14.90 10.44 21 571393 8985 90048048
Papulopustular rosacea 14.89 10.44 7 571407 44 90056989
Peritonitis bacterial 14.83 10.44 7 571407 5164 90051869
Sudden death 14.74 10.44 29 571385 10880 90046153
Cyanosis neonatal 14.72 10.44 16 571398 427 90056606
Rheumatoid lung 14.70 10.44 58 571356 4045 90052988
Axial spondyloarthritis 14.69 10.44 19 571395 612 90056421
Breast mass 14.68 10.44 23 571391 9424 90047609
Pallor 14.66 10.44 141 571273 34024 90023009
Haematuria 14.65 10.44 145 571269 34792 90022241
Skin tightness 14.63 10.44 5 571409 4483 90052550
Sensory disturbance 14.63 10.44 49 571365 15364 90041669
Adactyly 14.63 10.44 7 571407 46 90056987
Cyanosis 14.55 10.44 68 571346 19387 90037646
Hepatic enzyme abnormal 14.55 10.44 16 571398 7626 90049407
Deafness neurosensory 14.54 10.44 13 571401 6828 90050205
Neutrophil count abnormal 14.54 10.44 4 571410 4124 90052909
Acute hepatic failure 14.54 10.44 83 571331 22478 90034555
Dyspnoea at rest 14.51 10.44 6 571408 4785 90052248
Substance abuse 14.49 10.44 8 571406 5398 90051635
Post-traumatic stress disorder 14.49 10.44 13 571401 6815 90050218
Keratopathy 14.46 10.44 20 571394 688 90056345
Gingival bleeding 14.41 10.44 47 571367 14856 90042177
Hepatic steatosis 14.40 10.44 156 571258 36789 90020244
Parosmia 14.36 10.44 14 571400 7055 90049978
Immune-mediated enterocolitis 14.34 10.44 6 571408 4751 90052282
Retching 14.31 10.44 67 571347 19092 90037941
Polycystic ovaries 14.26 10.44 9 571405 5645 90051388
Blood albumin decreased 14.24 10.44 56 571358 16747 90040286
Internal haemorrhage 14.23 10.44 11 571403 6209 90050824
End stage renal disease 14.16 10.44 20 571394 8551 90048482
Foetal death 14.15 10.44 196 571218 20527 90036506
Carotid artery stenosis 14.14 10.44 8 571406 5326 90051707
Ileus 14.12 10.44 55 571359 16491 90040542
Quality of life decreased 14.08 10.44 34 571380 11855 90045178
Blood disorder 14.08 10.44 17 571397 7773 90049260
Lung neoplasm 14.08 10.44 13 571401 6722 90050311
Mydriasis 14.06 10.44 48 571366 14964 90042069
Exposure via skin contact 14.00 10.44 29 571385 10676 90046357
Foot operation 13.97 10.44 101 571313 8900 90048133
Limb injury 13.96 10.44 129 571285 31379 90025654
Synovial cyst 13.95 10.44 124 571290 11628 90045405
Therapeutic reaction time decreased 13.95 10.44 3 571411 3655 90053378
Orbital oedema 13.94 10.44 14 571400 340 90056693
Hepatitis acute 13.81 10.44 30 571384 10857 90046176
Aplasia 13.81 10.44 4 571410 3987 90053046
Cerebral ischaemia 13.77 10.44 15 571399 7181 90049852
Eating disorder 13.75 10.44 112 571302 27961 90029072
Squamous cell carcinoma of skin 13.74 10.44 16 571398 7433 90049600
Embolism venous 13.74 10.44 3 571411 3617 90053416
Dry throat 13.73 10.44 18 571396 7942 90049091
Arterial haemorrhage 13.73 10.44 41 571373 2482 90054551
Forced expiratory volume decreased 13.64 10.44 10 571404 5798 90051235
Drug specific antibody present 13.60 10.44 9 571405 5505 90051528
Cerebral haematoma 13.60 10.44 5 571409 4284 90052749
Eye swelling 13.60 10.44 119 571295 29267 90027766
Cytomegalovirus test positive 13.58 10.44 3 571411 3588 90053445
Abscess 13.56 10.44 67 571347 18824 90038209
Angina unstable 13.55 10.44 15 571399 7128 90049905
Oxygen consumption increased 13.50 10.44 6 571408 4583 90052450
Catheter site erythema 13.47 10.44 7 571407 4887 90052146
Serum ferritin increased 13.46 10.44 16 571398 7365 90049668
Intestinal ischaemia 13.45 10.44 22 571392 8861 90048172
Angiopathy 13.45 10.44 9 571405 5471 90051562
Blood pressure diastolic abnormal 13.43 10.44 72 571342 19809 90037224
Kounis syndrome 13.43 10.44 41 571373 2512 90054521
Sebaceous gland infection 13.40 10.44 10 571404 160 90056873
Skin necrosis 13.40 10.44 58 571356 16883 90040150
Intentional dose omission 13.39 10.44 62 571352 17721 90039312
Libido disorder 13.38 10.44 7 571407 57 90056976
Corneal epithelium defect 13.38 10.44 16 571398 475 90056558
Oesophageal candidiasis 13.33 10.44 14 571400 6815 90050218
Congenital pulmonary hypertension 13.32 10.44 9 571405 122 90056911
Increased tendency to bruise 13.31 10.44 35 571379 11855 90045178
Colorectal cancer 13.29 10.44 4 571410 3889 90053144
Ankle impingement 13.29 10.44 5 571409 16 90057017
Blood immunoglobulin G decreased 13.29 10.44 3 571411 3535 90053498
Homicide 13.27 10.44 13 571401 306 90056727
Drug hypersensitivity 13.25 10.44 3205 568209 460404 89596629
Colitis microscopic 13.15 10.44 32 571382 11127 90045906
Type 1 diabetes mellitus 13.07 10.44 7 571407 4805 90052228
Sluggishness 13.06 10.44 11 571403 5948 90051085
White blood cells urine positive 13.05 10.44 13 571401 6485 90050548
Maternal exposure during delivery 13.04 10.44 4 571410 3842 90053191
Potentiating drug interaction 12.97 10.44 10 571404 5652 90051381
Formication 12.97 10.44 7 571407 4784 90052249
Dialysis 12.95 10.44 33 571381 11296 90045737
Mouth haemorrhage 12.92 10.44 21 571393 8480 90048553
Blood pressure systolic abnormal 12.91 10.44 71 571343 19407 90037626
Injection site hyperaesthesia 12.88 10.44 7 571407 62 90056971
Injury associated with device 12.87 10.44 6 571408 4458 90052575
Conjunctivitis 12.87 10.44 107 571307 26599 90030434
Brain injury 12.84 10.44 18 571396 7720 90049313
Azotaemia 12.83 10.44 9 571405 5339 90051694
Skin papilloma 12.83 10.44 10 571404 5620 90051413
Respiratory alkalosis 12.80 10.44 3 571411 3445 90053588
Psoriasis 12.79 10.44 1090 570324 146664 89910369
Gastrointestinal haemorrhage 12.74 10.44 453 570961 89795 89967238
Dysphoria 12.72 10.44 12 571402 6142 90050891
Nephrogenic systemic fibrosis 12.68 10.44 5 571409 4103 90052930
Stillbirth 12.67 10.44 17 571397 7426 90049607
Infusion site extravasation 12.66 10.44 29 571385 10299 90046734
Cardiac pacemaker insertion 12.59 10.44 6 571408 4401 90052632
Device failure 12.52 10.44 15 571399 6882 90050151
Creutzfeldt-Jakob disease 12.51 10.44 10 571404 178 90056855
Epidermal necrosis 12.50 10.44 38 571376 2323 90054710
Normal newborn 12.50 10.44 212 571202 23150 90033883
Dermo-hypodermitis 12.47 10.44 20 571394 787 90056246
Aortic valve incompetence 12.46 10.44 14 571400 6610 90050423
Pancreatic carcinoma 12.45 10.44 21 571393 8356 90048677
Ventricular dysfunction 12.44 10.44 4 571410 3727 90053306
Dermatitis acneiform 12.43 10.44 13 571401 6341 90050692
Acidosis 12.43 10.44 40 571374 12696 90044337
Stress fracture 12.42 10.44 22 571392 8589 90048444
Vein disorder 12.41 10.44 10 571404 5526 90051507
Petechiae 12.38 10.44 54 571360 15687 90041346
Dermatitis contact 12.38 10.44 44 571370 13551 90043482
Colectomy 12.36 10.44 3 571411 3364 90053669
Endocarditis 12.36 10.44 16 571398 7097 90049936
Nail operation 12.35 10.44 33 571381 1873 90055160
Biliary obstruction 12.33 10.44 3 571411 3359 90053674
Temperature intolerance 12.29 10.44 37 571377 11993 90045040
Pyoderma streptococcal 12.29 10.44 4 571410 7 90057026
Vulvovaginal mycotic infection 12.26 10.44 13 571401 6301 90050732
Pharyngeal oedema 12.25 10.44 45 571369 13726 90043307
Brain death 12.24 10.44 5 571409 4016 90053017
Cardiac valve disease 12.22 10.44 7 571407 4628 90052405
Behaviour disorder 12.22 10.44 7 571407 4628 90052405
Pseudodiverticular disease 12.22 10.44 3 571411 0 90057033
Application site eczema 12.22 10.44 3 571411 0 90057033
Retinal detachment 12.21 10.44 15 571399 6807 90050226
Cerebral infarction 12.17 10.44 108 571306 26488 90030545
Stupor 12.16 10.44 10 571404 5472 90051561
Increased appetite 12.15 10.44 36 571378 11729 90045304
Blood phosphorus increased 12.15 10.44 6 571408 4312 90052721
Ear pruritus 12.13 10.44 15 571399 6788 90050245
Injection site irritation 12.12 10.44 12 571402 6003 90051030
Tooth loss 12.11 10.44 18 571396 7536 90049497
Melanocytic naevus 12.09 10.44 9 571405 5177 90051856
Hydronephrosis 12.07 10.44 39 571375 12363 90044670
Atrial tachycardia 12.01 10.44 12 571402 5978 90051055
Blepharitis 12.01 10.44 5 571409 3971 90053062
High density lipoprotein 11.95 10.44 4 571410 8 90057025
Blood triglycerides 11.95 10.44 4 571410 8 90057025
Total cholesterol/HDL ratio 11.95 10.44 4 571410 8 90057025
Intestinal perforation 11.93 10.44 46 571368 13835 90043198
Oral disorder 11.93 10.44 30 571384 10315 90046718
Urine leukocyte esterase positive 11.90 10.44 3 571411 3279 90053754
Porphyrins urine increased 11.90 10.44 5 571409 23 90057010
Creatinine renal clearance increased 11.89 10.44 3 571411 3278 90053755
Blue toe syndrome 11.89 10.44 15 571399 471 90056562
Bronchial secretion retention 11.83 10.44 4 571410 3611 90053422
Anhedonia 11.79 10.44 35 571379 11396 90045637
Foetal growth restriction 11.77 10.44 26 571388 9354 90047679
Proctalgia 11.77 10.44 21 571393 8177 90048856
Infection susceptibility increased 11.76 10.44 5 571409 3921 90053112
Sinus pain 11.75 10.44 10 571404 5379 90051654
General physical condition abnormal 11.75 10.44 9 571405 5102 90051931
Neoplasm 11.74 10.44 24 571390 8879 90048154
Abdominal abscess 11.74 10.44 10 571404 5377 90051656
Pleural fibrosis 11.73 10.44 4 571410 3592 90053441
Obstruction 11.73 10.44 5 571409 3916 90053117
Pulmonary arterial pressure increased 11.71 10.44 5 571409 3911 90053122
Streptococcal sepsis 11.67 10.44 4 571410 3580 90053453
Colon cancer 11.66 10.44 33 571381 10911 90046122
Peripheral vascular disorder 11.66 10.44 14 571400 6417 90050616
Idiopathic intracranial hypertension 11.66 10.44 4 571410 3577 90053456
Vitamin D deficiency 11.63 10.44 64 571350 17492 90039541
Nephropathy toxic 11.59 10.44 41 571373 12647 90044386
Renal injury 11.58 10.44 30 571384 10213 90046820
Demyelination 11.56 10.44 21 571393 8119 90048914
Skin reaction 11.56 10.44 69 571345 18484 90038549
Femoral neck fracture 11.55 10.44 30 571384 10203 90046830
Sensitisation 11.45 10.44 6 571408 4169 90052864
Muscle spasms 11.41 10.44 1782 569632 250101 89806932
Application site injury 11.41 10.44 5 571409 26 90057007
Tissue infiltration 11.36 10.44 20 571394 850 90056183
Fungal skin infection 11.36 10.44 10 571404 5291 90051742
Ischaemia 11.33 10.44 10 571404 5285 90051748
Osteoporotic fracture 11.32 10.44 8 571406 4728 90052305
Impaired gastric emptying 11.30 10.44 42 571372 12767 90044266
Folate deficiency 11.27 10.44 3 571411 3162 90053871
Alpha tumour necrosis factor increased 11.25 10.44 5 571409 27 90057006
Bipolar disorder 11.20 10.44 25 571389 8960 90048073
Furuncle 11.20 10.44 19 571395 7542 90049491
Device defective 11.16 10.44 4 571410 3482 90053551
Affective disorder 11.16 10.44 20 571394 7773 90049260
Urinary retention 11.14 10.44 169 571245 37575 90019458
Gastrointestinal ulcer 11.11 10.44 41 571373 2770 90054263
Myocardial ischaemia 11.11 10.44 47 571367 13767 90043266
Immunodeficiency 11.11 10.44 354 571060 42880 90014153
Neutrophilia 11.11 10.44 12 571402 5766 90051267
Oesophageal carcinoma recurrent 11.11 10.44 5 571409 28 90057005
Underdose 11.07 10.44 431 570983 53586 90003447
Electroencephalogram abnormal 11.07 10.44 6 571408 4090 90052943
Bacterial sepsis 11.04 10.44 9 571405 4946 90052087
Gastric polyps 11.03 10.44 8 571406 4664 90052369
Incorrect drug administration rate 11.01 10.44 10 571404 5213 90051820
Electrocardiogram abnormal 11.01 10.44 31 571383 10267 90046766
Product administration interrupted 11.00 10.44 41 571373 12451 90044582
Poor quality sleep 10.99 10.44 101 571313 24592 90032441
Infusion site pruritus 10.97 10.44 16 571398 6749 90050284
Diaphragmatic hernia 10.95 10.44 17 571397 650 90056383
Organ failure 10.95 10.44 3 571411 3102 90053931
Gastric ulcer haemorrhage 10.94 10.44 64 571350 5247 90051786
Ear congestion 10.94 10.44 4 571410 3438 90053595
Intervertebral disc protrusion 10.94 10.44 114 571300 27082 90029951
Thrombocytosis 10.92 10.44 17 571397 6984 90050049
Shock haemorrhagic 10.90 10.44 40 571374 12205 90044828
Respiratory tract infection viral 10.90 10.44 3 571411 3093 90053940
Defaecation urgency 10.89 10.44 14 571400 6228 90050805
Vulvovaginal dryness 10.88 10.44 4 571410 3427 90053606
Cardiac flutter 10.87 10.44 8 571406 4630 90052403
Hypertransaminasaemia 10.87 10.44 57 571357 15768 90041265
Hidradenitis 10.85 10.44 7 571407 4340 90052693
Bundle branch block right 10.85 10.44 11 571403 5442 90051591
Porphyrins stool increased 10.82 10.44 5 571409 30 90057003
Meteoropathy 10.82 10.44 4 571410 12 90057021
Appendicitis 10.79 10.44 31 571383 10200 90046833
Social avoidant behaviour 10.79 10.44 4 571410 3409 90053624
Papilloedema 10.77 10.44 8 571406 4607 90052426
Application site ulcer 10.74 10.44 7 571407 89 90056944
Schizoaffective disorder 10.68 10.44 10 571404 5137 90051896
Death neonatal 10.68 10.44 34 571380 2131 90054902
Cholangitis 10.68 10.44 18 571396 7164 90049869
Bloody discharge 10.68 10.44 35 571379 2228 90054805
Tooth fracture 10.68 10.44 42 571372 12558 90044475
Leukoencephalopathy 10.67 10.44 9 571405 4864 90052169
Tender joint count 10.66 10.44 26 571388 1395 90055638
Anal fistula 10.64 10.44 7 571407 4294 90052739
Peripheral ischaemia 10.64 10.44 12 571402 5655 90051378
Gastric cancer 10.63 10.44 10 571404 5126 90051907
Adrenal insufficiency 10.62 10.44 129 571285 29792 90027241
Mouth swelling 10.62 10.44 12 571402 5650 90051383
Product physical issue 10.61 10.44 12 571402 5648 90051385
Cardiac massage 10.59 10.44 4 571410 13 90057020
Dermatomyositis 10.57 10.44 4 571410 3366 90053667
Ankle fracture 10.57 10.44 80 571334 20290 90036743
Cerebral atrophy 10.55 10.44 12 571402 5634 90051399
Cardiac failure chronic 10.55 10.44 12 571402 5634 90051399
Pemphigoid 10.54 10.44 26 571388 9000 90048033
Gastric infection 10.51 10.44 6 571408 3974 90053059
Autoimmune thyroiditis 10.50 10.44 13 571401 5880 90051153
Drug effect less than expected 10.47 10.44 14 571400 6124 90050909
Trismus 10.44 10.44 9 571405 4812 90052221

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ankylosing spondylitis 397.18 10.40 229 96171 6827 42518108
Embolia cutis medicamentosa 335.83 10.40 90 96310 264 42524671
Melaena 284.87 10.40 393 96007 38353 42486582
Death 272.13 10.40 404 95996 470781 42054154
Gastric ulcer 261.72 10.40 261 96139 18001 42506934
Kounis syndrome 199.43 10.40 113 96287 3255 42521680
Neck pain 179.22 10.40 276 96124 29738 42495197
Duodenal ulcer 169.51 10.40 172 96228 12107 42512828
Musculoskeletal stiffness 165.32 10.40 388 96012 57377 42467558
Febrile neutropenia 159.15 10.40 113 96287 185590 42339345
Glomerulonephritis minimal lesion 142.81 10.40 55 96345 631 42524304
Off label use 136.37 10.40 867 95533 637468 41887467
Joint swelling 132.55 10.40 396 96004 67626 42457309
Neutropenia 125.68 10.40 160 96240 199271 42325664
Nightmare 123.45 10.40 211 96189 24801 42500134
Angioedema 120.07 10.40 284 96116 42193 42482742
Arthralgia 117.22 10.40 830 95570 204408 42320527
Sedation 112.62 10.40 227 96173 30248 42494687
Onychoclasis 110.48 10.40 71 96329 2581 42522354
Intestinal diaphragm disease 110.10 10.40 37 96363 276 42524659
Nephrolithiasis 109.30 10.40 251 96149 36579 42488356
Gastritis erosive 108.34 10.40 101 96299 6402 42518533
Psoriatic arthropathy 106.98 10.40 198 96202 24769 42500166
Fractional exhaled nitric oxide increased 106.24 10.40 58 96342 1551 42523384
Inspiratory capacity decreased 105.59 10.40 72 96328 2895 42522040
Pain 103.53 10.40 924 95476 243924 42281011
Anaphylactic reaction 102.09 10.40 268 96132 42475 42482460
Large intestinal ulcer 97.84 10.40 64 96336 2399 42522536
Upper gastrointestinal haemorrhage 97.19 10.40 213 96187 30086 42494849
Large intestinal stenosis 95.50 10.40 58 96342 1905 42523030
Back pain 95.11 10.40 597 95803 141179 42383756
Duodenal ulcer perforation 92.96 10.40 55 96345 1721 42523214
Myoglobin blood increased 91.66 10.40 72 96328 3610 42521325
Thrombocytopenia 90.34 10.40 184 96216 190095 42334840
Haematemesis 88.71 10.40 205 96195 29994 42494941
Disease progression 88.64 10.40 117 96283 143539 42381396
Gastric ulcer haemorrhage 88.55 10.40 88 96312 6039 42518896
Anaphylactic shock 85.49 10.40 174 96226 23343 42501592
Exostosis 85.34 10.40 83 96317 5548 42519387
Sacroiliitis 84.89 10.40 54 96346 1928 42523007
Inflammation 84.71 10.40 216 96184 33631 42491304
Sensation of foreign body 84.27 10.40 68 96332 3545 42521390
Psoriasis 83.58 10.40 271 96129 48333 42476602
Hyperhidrosis 82.50 10.40 414 95986 90098 42434837
Ductus arteriosus premature closure 81.73 10.40 28 96372 223 42524712
Plantar fasciitis 80.70 10.40 62 96338 3008 42521927
Tooth loss 79.99 10.40 70 96330 4084 42520851
Abdominal pain upper 77.51 10.40 381 96019 82228 42442707
Nephrotic syndrome 77.29 10.40 97 96303 8621 42516314
Gastric haemorrhage 76.23 10.40 106 96294 10409 42514526
Periorbital oedema 75.03 10.40 71 96329 4586 42520349
Urticaria 73.45 10.40 347 96053 73689 42451246
Lymphoma 66.98 10.40 118 96282 14203 42510732
Head discomfort 66.90 10.40 70 96330 5107 42519828
Spinal pain 64.21 10.40 78 96322 6704 42518231
Acute kidney injury 61.27 10.40 1168 95232 366169 42158766
Cytokine release syndrome 61.14 10.40 13 96387 44514 42480421
Type I hypersensitivity 59.70 10.40 45 96355 2121 42522814
Pruritus 59.16 10.40 670 95730 188101 42336834
Fibromyalgia 58.03 10.40 57 96343 3856 42521079
Arthritis 57.97 10.40 218 96182 41847 42483088
Cardiac failure congestive 57.75 10.40 65 96335 85537 42439398
Terminal insomnia 57.57 10.40 32 96368 887 42524048
Macrocephaly 57.30 10.40 26 96374 461 42524474
Bronchospasm 54.95 10.40 102 96298 12783 42512152
C-reactive protein increased 54.59 10.40 286 96114 63274 42461661
Pyloric stenosis 54.57 10.40 31 96369 897 42524038
Antidepressant drug level above therapeutic 53.61 10.40 21 96379 253 42524682
Tubulointerstitial nephritis and uveitis syndrome 53.47 10.40 17 96383 104 42524831
Analgesic drug level above therapeutic 53.12 10.40 22 96378 309 42524626
Gastric ulcer perforation 53.07 10.40 32 96368 1037 42523898
Duodenal ulcer haemorrhage 50.49 10.40 64 96336 5744 42519191
Gastrointestinal haemorrhage 49.82 10.40 385 96015 97341 42427594
Sepsis 49.60 10.40 257 96143 199077 42325858
Gastritis 49.07 10.40 142 96258 23805 42501130
Peritonitis 48.80 10.40 121 96279 18512 42506423
Hospitalisation 48.46 10.40 58 96342 74272 42450663
Gastroduodenal ulcer 47.83 10.40 26 96374 689 42524246
Gastric perforation 47.64 10.40 46 96354 3047 42521888
Undifferentiated connective tissue disease 47.01 10.40 15 96385 93 42524842
Pelvic pain 45.67 10.40 46 96354 3208 42521727
Metastases to stomach 44.84 10.40 14 96386 80 42524855
Osteoarthritis 44.61 10.40 139 96261 24266 42500669
Application site rash 44.48 10.40 28 96372 981 42523954
Aspirin-exacerbated respiratory disease 44.22 10.40 19 96381 294 42524641
Pancytopenia 43.90 10.40 129 96271 117614 42407321
Product dose omission issue 43.67 10.40 190 96210 154175 42370760
Dactylitis 43.51 10.40 29 96371 1122 42523813
Brain natriuretic peptide increased 42.86 10.40 64 96336 6706 42518229
Discomfort 42.78 10.40 140 96260 25079 42499856
Product used for unknown indication 42.39 10.40 29 96371 1172 42523763
Ligament calcification 42.03 10.40 17 96383 224 42524711
Intentional overdose 41.77 10.40 228 96172 51228 42473707
Myelosuppression 41.13 10.40 20 96380 40441 42484494
Secretion discharge 41.12 10.40 67 96333 7568 42517367
Pneumonia 40.72 10.40 691 95709 421458 42103477
Gastrointestinal erosion 40.71 10.40 20 96380 427 42524508
Erythema 39.57 10.40 398 96002 108395 42416540
Seronegative arthritis 39.56 10.40 28 96372 1196 42523739
COVID-19 39.04 10.40 133 96267 115815 42409120
Ulcerative keratitis 37.84 10.40 34 96366 2054 42522881
Mucosal erosion 37.22 10.40 25 96375 980 42523955
Cardiogenic shock 37.17 10.40 17 96383 35623 42489312
Muscle swelling 37.08 10.40 19 96381 445 42524490
Neoplasm malignant 36.57 10.40 124 96276 22619 42502316
Musculoskeletal pain 36.56 10.40 161 96239 33179 42491756
Faeces discoloured 35.93 10.40 102 96298 16912 42508023
Peptic ulcer 35.20 10.40 41 96359 3371 42521564
Ductus arteriosus stenosis foetal 34.99 10.40 14 96386 179 42524756
Grip strength decreased 33.53 10.40 41 96359 3547 42521388
Uveitis 33.05 10.40 68 96332 9190 42515745
Injection site warmth 32.40 10.40 35 96365 2648 42522287
Secondary amyloidosis 31.61 10.40 12 96388 132 42524803
Burning sensation 31.56 10.40 112 96288 20901 42504034
Leukopenia 31.55 10.40 77 96323 74669 42450266
Lymphocyte stimulation test positive 31.37 10.40 19 96381 621 42524314
Ileal perforation 31.19 10.40 23 96377 1048 42523887
Platelet dysfunction 31.06 10.40 15 96385 308 42524627
Pulmonary embolism 30.98 10.40 152 96248 119460 42405475
Conjunctival hyperaemia 30.84 10.40 37 96363 3139 42521796
Aminoaciduria 30.76 10.40 14 96386 250 42524685
Erythema multiforme 30.70 10.40 69 96331 9908 42515027
Mastoid abscess 30.56 10.40 6 96394 0 42524935
Cerebral atrophy congenital 30.55 10.40 10 96390 68 42524867
Nasopharyngitis 30.39 10.40 307 96093 83689 42441246
Drug interaction 29.92 10.40 803 95597 266196 42258739
Corneal thinning 29.88 10.40 12 96388 155 42524780
Injection site necrosis 29.78 10.40 18 96382 586 42524349
Polyneuropathy in malignant disease 28.90 10.40 15 96385 361 42524574
Blood urea increased 28.44 10.40 148 96252 32645 42492290
Suicide attempt 28.32 10.40 190 96210 45910 42479025
Plasma cell myeloma 28.05 10.40 40 96360 47538 42477397
Gas gangrene 28.02 10.40 10 96390 91 42524844
Disability 27.89 10.40 49 96351 5884 42519051
Mycobacterium tuberculosis complex test positive 27.82 10.40 25 96375 1511 42523424
Oral herpes 27.62 10.40 56 96344 7488 42517447
Toxicity to various agents 27.22 10.40 360 96040 228776 42296159
Cerebrovascular accident 27.20 10.40 120 96280 97040 42427895
Cytomegalovirus infection 27.17 10.40 20 96380 32286 42492649
Drug tolerance decreased 27.13 10.40 30 96370 2330 42522605
Full blood count abnormal 27.13 10.40 17 96383 29859 42495076
Toxic epidermal necrolysis 26.96 10.40 126 96274 26624 42498311
Deep vein thrombosis 26.77 10.40 87 96313 76870 42448065
Neurotoxicity 26.73 10.40 10 96390 23641 42501294
Drug resistance 26.55 10.40 23 96377 34225 42490710
Peptic ulcer perforation 26.53 10.40 14 96386 349 42524586
Mobility decreased 26.37 10.40 153 96247 35153 42489782
Stevens-Johnson syndrome 25.77 10.40 109 96291 22069 42502866
Anorgasmia 25.67 10.40 21 96379 1116 42523819
Shock haemorrhagic 25.63 10.40 88 96312 16154 42508781
Right-to-left cardiac shunt 25.50 10.40 11 96389 172 42524763
Nerve stimulation test abnormal 25.47 10.40 5 96395 0 42524935
Laryngeal discomfort 25.41 10.40 12 96388 234 42524701
Corneal perforation 25.35 10.40 13 96387 305 42524630
Intestinal atony 25.29 10.40 8 96392 48 42524887
Intervertebral disc degeneration 25.00 10.40 53 96347 7314 42517621
Duodenitis 24.98 10.40 45 96355 5511 42519424
Electrocardiogram QT prolonged 24.77 10.40 44 96356 47901 42477034
Application site reaction 24.74 10.40 14 96386 402 42524533
Erosive duodenitis 24.58 10.40 25 96375 1764 42523171
Blood pressure measurement 24.56 10.40 11 96389 189 42524746
Synovial cyst 24.50 10.40 30 96370 2599 42522336
Duodenal perforation 24.45 10.40 24 96376 1622 42523313
Neuroleptic malignant syndrome 24.40 10.40 9 96391 21463 42503472
Hyperaesthesia 23.99 10.40 46 96354 5906 42519029
Self-medication 23.78 10.40 33 96367 3233 42521702
Diabetes mellitus 23.73 10.40 64 96336 60023 42464912
Axial spondyloarthritis 23.72 10.40 15 96385 530 42524405
Small intestine ulcer 23.69 10.40 15 96385 531 42524404
Myasthenia gravis 23.66 10.40 4 96396 16133 42508802
Mental status changes 23.28 10.40 37 96363 42078 42482857
Necrotising fasciitis 23.28 10.40 39 96361 4507 42520428
Neuropathy peripheral 23.27 10.40 135 96265 101718 42423217
Respiratory failure 23.20 10.40 182 96218 127950 42396985
Tubulointerstitial nephritis 23.10 10.40 136 96264 31412 42493523
Angiocardiogram 23.09 10.40 11 96389 219 42524716
Loss of personal independence in daily activities 22.89 10.40 49 96351 49767 42475168
Phonophobia 22.85 10.40 12 96388 296 42524639
Eczema herpeticum 22.85 10.40 12 96388 296 42524639
Iris hypopigmentation 22.72 10.40 7 96393 38 42524897
Platelet function test abnormal 22.64 10.40 9 96391 113 42524822
Microcytic anaemia 22.60 10.40 31 96369 3004 42521931
Blister 22.43 10.40 122 96278 27368 42497567
Gastric mucosal lesion 22.39 10.40 16 96384 694 42524241
Platelet count decreased 22.32 10.40 203 96197 138378 42386557
Haematochezia 22.30 10.40 216 96184 58220 42466715
Medium-chain acyl-coenzyme A dehydrogenase deficiency 22.27 10.40 7 96393 41 42524894
Cytopenia 22.26 10.40 6 96394 17491 42507444
Fragile X syndrome 21.99 10.40 7 96393 43 42524892
Malignant mesenteric neoplasm 21.99 10.40 7 96393 43 42524892
Corneal epithelium defect 21.91 10.40 13 96387 409 42524526
Drug ineffective 21.84 10.40 1680 94720 628517 41896418
Renal failure neonatal 21.63 10.40 9 96391 128 42524807
Sciatic nerve injury 21.38 10.40 9 96391 132 42524803
Anuria 21.36 10.40 66 96334 11466 42513469
Leptotrichia infection 21.32 10.40 8 96392 85 42524850
White blood cell count decreased 21.32 10.40 154 96246 110242 42414693
Renal tubular necrosis 21.17 10.40 90 96310 18264 42506671
Intentional product use issue 21.16 10.40 87 96313 71746 42453189
Acute myeloid leukaemia 21.14 10.40 12 96388 22244 42502691
Duodenal stenosis 21.10 10.40 12 96388 348 42524587
Nasal turbinate abnormality 20.97 10.40 7 96393 51 42524884
Transplant rejection 20.76 10.40 3 96397 13585 42511350
Face oedema 20.66 10.40 73 96327 13593 42511342
Hyperkalaemia 20.57 10.40 275 96125 80183 42444752
Ocular hyperaemia 20.57 10.40 81 96319 15882 42509053
Cryopyrin associated periodic syndrome 20.52 10.40 8 96392 95 42524840
Contraindicated product administered 20.51 10.40 112 96288 25160 42499775
Sleep disorder due to a general medical condition 20.37 10.40 7 96393 17446 42507489
Stomatitis 20.34 10.40 53 96347 50276 42474659
Atrial septal defect 20.28 10.40 51 96349 7868 42517067
Chronic obstructive pulmonary disease 20.15 10.40 74 96326 63040 42461895
Hypothyroidism 19.89 10.40 26 96374 32058 42492877
Hypervolaemia 19.86 10.40 14 96386 23111 42501824
Frequent bowel movements 19.69 10.40 12 96388 21395 42503540
Application site eczema 19.68 10.40 5 96395 11 42524924
Full blood count decreased 19.65 10.40 11 96389 20549 42504386
Kidney duplex 19.63 10.40 12 96388 399 42524536
Hypoaldosteronism 19.59 10.40 11 96389 311 42524624
Mesenteric neoplasm 19.56 10.40 6 96394 32 42524903
Muscle spasms 19.54 10.40 288 96112 85756 42439179
Body mass index abnormal 19.51 10.40 9 96391 166 42524769
Eschar 19.41 10.40 15 96385 734 42524201
Erythema induratum 19.38 10.40 5 96395 12 42524923
Intestinal congestion 19.38 10.40 5 96395 12 42524923
Pyrexia 19.31 10.40 713 95687 393329 42131606
Cold sweat 19.30 10.40 63 96337 11267 42513668
Tongue oedema 19.13 10.40 30 96370 3280 42521655
Trisomy 8 19.12 10.40 7 96393 69 42524866
No adverse event 19.11 10.40 37 96363 38984 42485951
Mast cell activation syndrome 19.10 10.40 11 96389 327 42524608
Dermatitis allergic 19.04 10.40 52 96348 8431 42516504
Lymph nodes scan abnormal 18.97 10.40 6 96394 36 42524899
Subacute endocarditis 18.77 10.40 7 96393 73 42524862
Gastritis haemorrhagic 18.76 10.40 21 96379 1653 42523282
Diarrhoea 18.74 10.40 852 95548 459997 42064938
Neutrophil count decreased 18.56 10.40 77 96323 63338 42461597
Non-cardiogenic pulmonary oedema 18.49 10.40 16 96384 919 42524016
Factor VIII deficiency 18.49 10.40 8 96392 126 42524809
Prostatic pain 18.48 10.40 11 96389 348 42524587
Appendicitis 18.34 10.40 12 96388 20601 42504334
Gastrointestinal ulcer 18.32 10.40 22 96378 1868 42523067
Pseudarthrosis 18.28 10.40 7 96393 79 42524856
Allodynia 18.24 10.40 17 96383 1077 42523858
Atrial fibrillation 18.17 10.40 215 96185 139378 42385557
Twin pregnancy 18.14 10.40 4 96396 3 42524932
Ventricular tachycardia 18.13 10.40 25 96375 30135 42494800
Ventricular fibrillation 18.08 10.40 25 96375 30098 42494837
Jejunal ulcer perforation 18.04 10.40 7 96393 82 42524853
Cognitive disorder 17.98 10.40 31 96369 34141 42490794
Intervertebral disc compression 17.96 10.40 11 96389 367 42524568
Hypoxia 17.87 10.40 89 96311 69697 42455238
Delirium 17.83 10.40 60 96340 52459 42472476
Ascites 17.74 10.40 67 96333 56611 42468324
Nikolsky's sign 17.73 10.40 8 96392 140 42524795
Migraine 17.61 10.40 108 96292 25306 42499629
Alopecia 17.58 10.40 120 96280 29156 42495779
Urinary tract infection 17.51 10.40 142 96258 99142 42425793
Craniofacial fracture 17.46 10.40 11 96389 386 42524549
Dermatosis 17.43 10.40 11 96389 387 42524548
Dry skin 17.26 10.40 54 96346 48284 42476651
Thrombosis 17.19 10.40 88 96312 68423 42456512
Drug intolerance 17.03 10.40 266 96134 80158 42444777
Electrocardiogram T wave peaked 16.99 10.40 14 96386 752 42524183
Abdominal lymphadenopathy 16.91 10.40 16 96384 1033 42523902
Application site oedema 16.91 10.40 5 96395 23 42524912
Oral pruritus 16.76 10.40 12 96388 522 42524413
Seizure 16.74 10.40 183 96217 120378 42404557
Bronchiectasis 16.71 10.40 10 96390 18009 42506926
Shock 16.68 10.40 118 96282 29003 42495932
Joint instability 16.60 10.40 12 96388 530 42524405
Gastric disorder 16.59 10.40 62 96338 11860 42513075
Omental necrosis 16.57 10.40 5 96395 25 42524910
Oculomucocutaneous syndrome 16.49 10.40 8 96392 166 42524769
Product administered at inappropriate site 16.43 10.40 27 96373 3071 42521864
Inflammatory bowel disease 16.40 10.40 29 96371 3500 42521435
Metastases to lung 16.39 10.40 60 96340 11364 42513571
Bronchopulmonary aspergillosis 16.37 10.40 12 96388 19417 42505518
Encephalopathy 16.34 10.40 44 96356 41289 42483646
Quality of life decreased 16.34 10.40 37 96363 5339 42519596
Foreign body in throat 16.33 10.40 12 96388 544 42524391
Application site swelling 16.31 10.40 10 96390 334 42524601
Application site hypersensitivity 16.31 10.40 7 96393 108 42524827
Condition aggravated 16.30 10.40 457 95943 260297 42264638
Generalised bullous fixed drug eruption 16.27 10.40 11 96389 436 42524499
Application site vesicles 16.25 10.40 13 96387 669 42524266
Large intestine perforation 16.22 10.40 53 96347 9483 42515452
Stress 16.06 10.40 49 96351 44163 42480772
Increased upper airway secretion 15.95 10.40 24 96376 2532 42522403
Hypertension 15.94 10.40 274 96126 166930 42358005
Visual evoked potentials abnormal 15.89 10.40 6 96394 65 42524870
Aspergillus infection 15.83 10.40 8 96392 15829 42509106
Bacteraemia 15.82 10.40 20 96380 25020 42499915
Hyponatraemia 15.74 10.40 150 96250 101312 42423623
Blood lactate dehydrogenase increased 15.72 10.40 107 96293 25974 42498961
Mucosal inflammation 15.69 10.40 58 96342 49316 42475619
Eastern Cooperative Oncology Group performance status 15.67 10.40 5 96395 31 42524904
Pneumothorax 15.65 10.40 99 96301 23444 42501491
Myelodysplastic syndrome 15.63 10.40 17 96383 22728 42502207
Foot deformity 15.53 10.40 35 96365 5033 42519902
Ciliary hyperaemia 15.53 10.40 5 96395 32 42524903
Wound secretion 15.43 10.40 25 96375 2810 42522125
Skin ulcer 15.41 10.40 105 96295 25496 42499439
Pericardial calcification 15.40 10.40 5 96395 33 42524902
Blood test abnormal 15.37 10.40 5 96395 12901 42512034
Purpura fulminans 15.36 10.40 8 96392 194 42524741
Pneumonitis 15.32 10.40 46 96354 41672 42483263
Jaundice 15.30 10.40 132 96268 34457 42490478
Leucine aminopeptidase increased 15.28 10.40 3 96397 0 42524935
Internal limiting membrane peeling 15.28 10.40 3 96397 0 42524935
Anxiety 15.27 10.40 183 96217 118377 42406558
Palmoplantar pustulosis 15.25 10.40 11 96389 484 42524451
Arthritis bacterial 15.25 10.40 38 96362 5830 42519105
Mallory-Weiss syndrome 15.23 10.40 18 96382 1503 42523432
Lipid metabolism disorder 15.22 10.40 11 96389 486 42524449
Joint space narrowing 15.21 10.40 8 96392 198 42524737
Bladder cancer 15.07 10.40 10 96390 17037 42507898
Diabetic ketoacidosis 15.06 10.40 17 96383 22350 42502585
Laryngeal oedema 14.97 10.40 30 96370 3978 42520957
Skull fractured base 14.89 10.40 8 96392 207 42524728
Malignant neoplasm progression 14.87 10.40 165 96235 108235 42416700
Paraesthesia 14.81 10.40 241 96159 73218 42451717
Trigeminal neuralgia 14.78 10.40 18 96382 1551 42523384
Glomerulonephritis rapidly progressive 14.77 10.40 14 96386 906 42524029
Gastrointestinal mucosal exfoliation 14.75 10.40 7 96393 138 42524797
Intestinal ulcer 14.70 10.40 15 96385 1062 42523873
Kidney infection 14.70 10.40 41 96359 6729 42518206
Lipoma 14.68 10.40 21 96379 2117 42522818
Nodule 14.68 10.40 5 96395 12529 42512406
Tendon disorder 14.66 10.40 27 96373 3362 42521573
Swelling 14.61 10.40 189 96211 54696 42470239
Oral mucosa erosion 14.60 10.40 15 96385 1071 42523864
Costovertebral angle tenderness 14.57 10.40 6 96394 83 42524852
Defaecation disorder 14.48 10.40 7 96393 144 42524791
Ventricular hypertrophy 14.47 10.40 33 96367 4783 42520152
Dysphonia 14.43 10.40 112 96288 28338 42496597
Nasal abscess 14.39 10.40 4 96396 14 42524921
Cytomegalovirus viraemia 14.30 10.40 3 96397 10374 42514561
Gastric mucosa erythema 14.28 10.40 9 96391 316 42524619
Hypoosmolar state 14.27 10.40 7 96393 149 42524786
Xanthelasma 14.19 10.40 6 96394 89 42524846
Incorrect product administration duration 14.16 10.40 37 96363 5843 42519092
Skin graft 14.15 10.40 11 96389 543 42524392
Intervertebral disc protrusion 14.12 10.40 56 96344 11016 42513919
Sciatic nerve palsy 14.06 10.40 5 96395 45 42524890
Ureteral disorder 13.98 10.40 7 96393 156 42524779
Endoscopy abnormal 13.97 10.40 4 96396 16 42524919
Gingivitis ulcerative 13.94 10.40 8 96392 236 42524699
Dehydration 13.94 10.40 231 96169 141536 42383399
Fixed eruption 13.85 10.40 22 96378 2432 42522503
Tonsil cancer 13.77 10.40 15 96385 1146 42523789
CADASIL 13.61 10.40 6 96394 99 42524836
Nodal osteoarthritis 13.56 10.40 8 96392 249 42524686
Intestinal metaplasia 13.51 10.40 5 96395 51 42524884
Treatment noncompliance 13.51 10.40 42 96358 37630 42487305
Bone marrow oedema 13.43 10.40 13 96387 864 42524071
Troponin increased 13.37 10.40 14 96386 19048 42505887
Feeling hot 13.36 10.40 95 96305 23387 42501548
Orthostatic hypotension 13.28 10.40 31 96369 30539 42494396
Deafness congenital 13.19 10.40 6 96394 107 42524828
Persistent corneal epithelial defect 13.17 10.40 5 96395 55 42524880
Application site erythema 13.12 10.40 22 96378 2544 42522391
Pain in extremity 13.06 10.40 439 95961 150165 42374770
Tumour invasion 13.04 10.40 9 96391 369 42524566
Pseudoporphyria 13.03 10.40 10 96390 484 42524451
Musculoskeletal discomfort 12.96 10.40 49 96351 9427 42515508
Discoloured vomit 12.88 10.40 12 96388 760 42524175
Chronic gastritis 12.82 10.40 20 96380 2177 42522758
Upper gastrointestinal perforation 12.79 10.40 4 96396 23 42524912
Tissue infiltration 12.76 10.40 7 96393 189 42524746
Gastric bypass 12.74 10.40 8 96392 279 42524656
Microcephaly 12.74 10.40 13 96387 921 42524014
Duodenal obstruction 12.73 10.40 7 96393 190 42524745
Cardio-respiratory arrest 12.71 10.40 79 96321 58557 42466378
Lentigo maligna 12.68 10.40 9 96391 386 42524549
Pulmonary alveolar haemorrhage 12.68 10.40 9 96391 14807 42510128
Pathogen resistance 12.68 10.40 5 96395 11445 42513490
Weight increased 12.67 10.40 170 96230 107813 42417122
Tryptase decreased 12.65 10.40 4 96396 24 42524911
Hypersensitivity 12.63 10.40 232 96168 72138 42452797
Nasal septum deviation 12.59 10.40 15 96385 1263 42523672
Skin erosion 12.47 10.40 23 96377 2868 42522067
HLA marker study positive 12.47 10.40 7 96393 198 42524737
Retinal toxicity 12.46 10.40 10 96390 517 42524418
Sciatic nerve neuropathy 12.42 10.40 5 96395 65 42524870
Nasal turbinate hypertrophy 12.40 10.40 7 96393 200 42524735
Corneal opacity 12.39 10.40 11 96389 654 42524281
Craniocerebral injury 12.34 10.40 27 96373 3807 42521128
Energy increased 12.32 10.40 16 96384 1471 42523464
Cross sensitivity reaction 12.31 10.40 17 96383 1658 42523277
Double stranded DNA antibody positive 12.28 10.40 7 96393 204 42524731
Injection site mass 12.27 10.40 45 96355 8530 42516405
Prurigo 12.24 10.40 11 96389 665 42524270
Blood pressure immeasurable 12.24 10.40 13 96387 965 42523970
Skin lesion 12.17 10.40 104 96296 27070 42497865
Pallor 12.13 10.40 109 96291 28777 42496158
Infusion related reaction 12.13 10.40 84 96316 60722 42464213
Ependymoma malignant 12.12 10.40 4 96396 28 42524907
Febrile bone marrow aplasia 12.03 10.40 4 96396 10177 42514758
Perineal pain 11.99 10.40 13 96387 988 42523947
Small intestinal haemorrhage 11.96 10.40 20 96380 2308 42522627
Poisoning deliberate 11.92 10.40 50 96350 10084 42514851
Tumour lysis syndrome 11.85 10.40 20 96380 22211 42502724
Product label issue 11.81 10.40 8 96392 318 42524617
Agitation 11.79 10.40 91 96309 64223 42460712
Hypoglycaemia 11.79 10.40 83 96317 59771 42465164
Hepatic mass 11.76 10.40 14 96386 1178 42523757
Magnetic resonance imaging spinal abnormal 11.73 10.40 6 96394 140 42524795
Retroperitoneal fibrosis 11.60 10.40 9 96391 443 42524492
Hyperglycaemia 11.45 10.40 59 96341 45800 42479135
Clostridium difficile colitis 11.44 10.40 19 96381 21233 42503702
Purulent pericarditis 11.35 10.40 4 96396 35 42524900
Hypotension 11.32 10.40 472 95928 257159 42267776
Obstruction gastric 11.30 10.40 13 96387 1055 42523880
Weight bearing difficulty 11.24 10.40 14 96386 1234 42523701
Tachycardia 11.19 10.40 161 96239 100926 42424009
Papillary renal cell carcinoma 11.17 10.40 8 96392 348 42524587
Spondyloarthropathy 11.17 10.40 12 96388 902 42524033
Joint effusion 11.16 10.40 34 96366 5863 42519072
Nail discomfort 11.15 10.40 4 96396 37 42524898
Peritonsillitis 11.14 10.40 3 96397 9 42524926
Remission not achieved 11.11 10.40 6 96394 157 42524778
Saccadic eye movement 10.97 10.40 6 96394 161 42524774
Myofascial pain syndrome 10.96 10.40 8 96392 359 42524576
Laryngeal obstruction 10.91 10.40 3 96397 10 42524925
Duodenal ulcer repair 10.91 10.40 3 96397 10 42524925
N-terminal prohormone brain natriuretic peptide decreased 10.91 10.40 3 96397 10 42524925
Shock symptom 10.90 10.40 6 96394 163 42524772
Impaired healing 10.90 10.40 71 96329 16982 42507953
Bursitis 10.89 10.40 35 96365 6209 42518726
Metatarsalgia 10.85 10.40 5 96395 92 42524843
Sudden cardiac death 10.82 10.40 26 96374 3898 42521037
Carpal tunnel decompression 10.80 10.40 7 96393 258 42524677
Oropharyngeal pain 10.73 10.40 145 96255 42365 42482570
Enterococcal infection 10.72 10.40 7 96393 12032 42512903
Tendon discomfort 10.71 10.40 8 96392 372 42524563
Cardiac septal defect 10.69 10.40 12 96388 948 42523987
Synovitis 10.69 10.40 66 96334 15501 42509434
Skin necrosis 10.66 10.40 35 96365 6279 42518656
Clostridium difficile infection 10.65 10.40 22 96378 22637 42502298
Corneal infiltrates 10.64 10.40 6 96394 171 42524764
Adverse drug reaction 10.61 10.40 46 96354 37388 42487547
Pulmonary contusion 10.61 10.40 5 96395 97 42524838
Device leakage 10.58 10.40 5 96395 10280 42514655
Red blood cell sedimentation rate decreased 10.57 10.40 7 96393 268 42524667
Intestinal ischaemia 10.56 10.40 4 96396 9384 42515551
Nail bed inflammation 10.49 10.40 6 96394 176 42524759
Generalised tonic-clonic seizure 10.49 10.40 28 96372 26351 42498584
Dysstasia 10.49 10.40 61 96339 14025 42510910
Anterior chamber cleavage syndrome 10.48 10.40 3 96397 12 42524923
Hyponatriuria 10.48 10.40 3 96397 12 42524923
Coagulation test abnormal 10.46 10.40 10 96390 654 42524281
Groin pain 10.45 10.40 34 96366 6070 42518865
Hypoproteinaemia 10.45 10.40 21 96379 2791 42522144

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 2156.91 10.60 3758 524441 210812 109850288
Glossodynia 2006.09 10.60 3712 524487 218292 109842808
Systemic lupus erythematosus 1969.97 10.60 3984 524215 250354 109810746
Hand deformity 1956.15 10.60 3639 524560 214867 109846233
Pericarditis 1825.21 10.60 3539 524660 215575 109845525
Wound 1728.66 10.60 3599 524600 230838 109830262
Duodenal ulcer perforation 1707.31 10.60 3052 525147 174648 109886452
Anti-cyclic citrullinated peptide antibody positive 1665.07 10.60 3060 525139 178924 109882176
Rheumatoid arthritis 1542.73 10.60 3994 524205 295619 109765481
Helicobacter infection 1517.16 10.60 2940 525259 178937 109882163
Synovitis 1482.84 10.60 3723 524476 270369 109790731
Folliculitis 1320.63 10.60 2646 525553 165007 109896093
Arthropathy 1300.12 10.60 3654 524545 283868 109777232
Discomfort 1268.97 10.60 3018 525181 211689 109849411
Muscle injury 1200.71 10.60 2298 525901 138509 109922591
Irritable bowel syndrome 1197.98 10.60 2511 525688 161704 109899396
Swelling 1162.39 10.60 4003 524196 347038 109714062
Joint swelling 1132.71 10.60 4648 523551 438197 109622903
Death 1114.99 10.60 1019 527180 697850 109363250
Hepatic enzyme increased 1082.16 10.60 3682 524517 317210 109743890
Psoriatic arthropathy 1073.21 10.60 2682 525517 194079 109867021
Impaired healing 1047.41 10.60 2657 525542 194060 109867040
Embolia cutis medicamentosa 1042.25 10.60 320 527879 643 110060457
Alopecia 1026.96 10.60 3946 524253 360807 109700293
Blister 1026.71 10.60 2889 525310 224487 109836613
Abdominal discomfort 1022.81 10.60 4154 524045 389704 109671396
Rheumatic fever 983.43 10.60 1950 526249 120629 109940471
Contraindicated product administered 910.97 10.60 2932 525267 245335 109815765
Febrile neutropenia 899.82 10.60 205 527994 316562 109744538
Maternal exposure during pregnancy 873.31 10.60 2941 525258 251942 109809158
Neutropenia 865.27 10.60 353 527846 374267 109686833
Type 2 diabetes mellitus 858.53 10.60 2311 525888 174921 109886179
Rheumatoid factor positive 852.62 10.60 1919 526280 129721 109931379
Sleep disorder due to general medical condition, insomnia type 826.25 10.60 1663 526536 103980 109957120
Hypersensitivity 819.06 10.60 3958 524241 400040 109661060
Fibromyalgia 808.23 10.60 2209 525990 168700 109892400
Infusion related reaction 796.33 10.60 3767 524432 377395 109683705
Facet joint syndrome 710.84 10.60 1485 526714 95343 109965757
Lip dry 705.85 10.60 1510 526689 98573 109962527
Joint range of motion decreased 685.33 10.60 1681 526518 120151 109940949
Drug intolerance 684.44 10.60 3782 524417 402730 109658370
Musculoskeletal stiffness 679.13 10.60 2892 525307 276930 109784170
Ill-defined disorder 675.57 10.60 1960 526239 154893 109906207
Swollen joint count increased 662.53 10.60 1324 526875 82337 109978763
Bursitis 649.13 10.60 1714 526485 128204 109932896
Injury 647.60 10.60 2091 526108 175174 109885926
Grip strength decreased 638.71 10.60 1272 526927 78902 109982198
Toxicity to various agents 635.36 10.60 818 527381 479737 109581363
Osteoarthritis 622.31 10.60 2104 526095 180519 109880581
Liver injury 621.44 10.60 1852 526347 148561 109912539
Gastrointestinal disorder 591.90 10.60 2507 525692 239445 109821655
Blood cholesterol increased 589.66 10.60 2083 526116 182702 109878398
Therapeutic product effect decreased 587.26 10.60 2518 525681 241798 109819302
Stomatitis 582.37 10.60 2696 525503 267546 109793554
Lower respiratory tract infection 579.31 10.60 2499 525700 240607 109820493
Disease progression 571.31 10.60 225 527974 243809 109817291
Hypotension 549.30 10.60 1042 527157 522807 109538293
Peripheral venous disease 519.82 10.60 1204 526995 82913 109978187
Wound infection 515.09 10.60 1305 526894 95160 109965940
Mobility decreased 501.45 10.60 2355 525844 235067 109826033
Cough 495.60 10.60 905 527294 460736 109600364
Breast cancer stage III 479.65 10.60 1124 527075 77993 109983107
Sepsis 465.49 10.60 526 527673 326820 109734280
Completed suicide 438.58 10.60 311 527888 242070 109819030
Product dose omission issue 436.18 10.60 537 527662 321245 109739855
Night sweats 434.76 10.60 1519 526680 132464 109928636
Gait inability 432.08 10.60 1534 526665 134842 109926258
Off label use 410.81 10.60 4893 523306 1495292 108565808
Pancytopenia 409.02 10.60 247 527952 209366 109851734
Anaemia 398.02 10.60 1313 526886 545773 109515327
Deep vein thrombosis postoperative 397.88 10.60 877 527322 58414 110002686
Hypoaesthesia 394.85 10.60 2712 525487 311511 109749589
Obesity 391.29 10.60 1312 526887 112039 109949061
Thrombocytopenia 388.68 10.60 668 527531 348217 109712883
Treatment failure 384.13 10.60 2452 525747 274782 109786318
COVID-19 381.93 10.60 364 527835 244696 109816404
Live birth 365.69 10.60 935 527264 68549 109992551
Atrial fibrillation 363.86 10.60 336 527863 229306 109831794
Musculoskeletal pain 362.13 10.60 1782 526417 181241 109879859
Platelet count decreased 353.63 10.60 347 527852 230096 109831004
Prescribed overdose 352.71 10.60 1069 527130 86512 109974588
Lower limb fracture 351.02 10.60 969 527230 74379 109986721
Ankylosing spondylitis 349.94 10.60 402 527797 15210 110045890
Road traffic accident 343.54 10.60 1212 526987 106186 109954914
Hypercholesterolaemia 342.87 10.60 1084 527115 89753 109971347
Autoimmune disorder 342.38 10.60 879 527320 64604 109996496
Cardiac failure congestive 342.31 10.60 146 528053 150854 109910246
Nail disorder 340.20 10.60 813 527386 57122 110003978
Pneumonia 339.32 10.60 2624 525575 874090 109187010
Sciatica 337.26 10.60 1090 527109 91309 109969791
C-reactive protein abnormal 335.02 10.60 1367 526832 128328 109932772
Inflammation 334.10 10.60 1812 526387 191426 109869674
Dry mouth 333.69 10.60 1857 526342 198091 109863009
Urticaria 324.98 10.60 2619 525580 316238 109744862
Constipation 321.88 10.60 775 527424 357011 109704089
Sleep disorder 319.67 10.60 1827 526372 196817 109864283
Dislocation of vertebra 313.14 10.60 664 527535 43057 110018043
White blood cell count decreased 309.50 10.60 384 527815 229006 109832094
Nasopharyngitis 305.86 10.60 3052 525147 391309 109669791
Dehydration 304.13 10.60 543 527656 278968 109782132
Malignant neoplasm progression 300.25 10.60 236 527963 174331 109886769
Adjustment disorder with depressed mood 298.85 10.60 653 527546 43230 110017870
Myelosuppression 297.50 10.60 47 528152 94293 109966807
Seizure 295.55 10.60 373 527826 220812 109840288
Respiratory failure 294.16 10.60 357 527842 214975 109846125
Contusion 293.51 10.60 2015 526184 231346 109829754
Product use issue 292.95 10.60 2514 525685 309181 109751919
Pain 290.70 10.60 6275 521924 948680 109112420
Peripheral swelling 287.28 10.60 3072 525127 400962 109660138
Retinitis 286.88 10.60 537 527662 31790 110029310
Electrocardiogram QT prolonged 285.23 10.60 83 528116 108877 109952223
Diarrhoea 277.45 10.60 3807 524392 1135698 108925402
Pulmonary embolism 272.93 10.60 375 527824 214099 109847001
Cardiac failure 268.19 10.60 300 527899 187326 109873774
Hip arthroplasty 266.15 10.60 724 527475 55089 110006011
Cerebrovascular accident 265.59 10.60 284 527915 181000 109880100
Wheezing 260.83 10.60 2098 526101 253132 109807968
Onychomadesis 259.74 10.60 633 527566 45030 110016070
General physical health deterioration 258.34 10.60 3136 525063 422159 109638941
Blepharospasm 258.04 10.60 708 527491 54143 110006957
Urinary tract infection 249.67 10.60 765 527434 325517 109735583
Cardiac arrest 249.36 10.60 345 527854 196408 109864692
Neutrophil count decreased 246.58 10.60 135 528064 120806 109940294
Neuropathy peripheral 245.09 10.60 297 527902 178980 109882120
Hypoxia 242.43 10.60 160 528039 129355 109931745
Weight increased 237.98 10.60 3055 525144 416589 109644511
Lupus vulgaris 236.20 10.60 509 527690 33374 110027726
Product label confusion 233.60 10.60 402 527797 22275 110038825
Back injury 231.17 10.60 620 527579 46779 110014321
Lung disorder 229.50 10.60 1560 526639 178487 109882613
Coeliac disease 229.14 10.60 583 527616 42604 110018496
Cytokine release syndrome 228.66 10.60 32 528167 70274 109990826
Drug abuse 225.91 10.60 310 527889 177101 109883999
Nausea 225.19 10.60 4356 523843 1231334 108829766
X-ray abnormal 221.73 10.60 533 527666 37584 110023516
Sinusitis 221.65 10.60 2279 525920 294409 109766691
Knee arthroplasty 218.99 10.60 746 527453 64202 109996898
Infection 218.66 10.60 2668 525531 359532 109701568
Arthralgia 214.89 10.60 5053 523146 774579 109286521
C-reactive protein 211.84 10.60 456 527743 29875 110031225
Neck pain 209.62 10.60 1150 527049 121980 109939120
Bradycardia 209.03 10.60 261 527938 155256 109905844
Intentional product use issue 208.44 10.60 1952 526247 245954 109815146
Fall 207.30 10.60 1863 526336 601619 109459481
Abdominal pain upper 205.29 10.60 2559 525640 346552 109714548
Exostosis 205.15 10.60 582 527617 45374 110015726
Exposure during pregnancy 204.14 10.60 1435 526764 165989 109895111
Pleural effusion 201.66 10.60 336 527863 177373 109883727
Hypokalaemia 199.68 10.60 353 527846 182095 109879005
Liver disorder 197.36 10.60 1259 526940 140984 109920116
Rash 194.84 10.60 5215 522984 815749 109245351
Leukopenia 193.48 10.60 256 527943 148535 109912565
Cardio-respiratory arrest 191.20 10.60 163 528036 115673 109945427
Septic shock 185.16 10.60 291 527908 157237 109903863
Laryngitis 184.36 10.60 532 527667 41879 110019221
Intestinal diaphragm disease 184.03 10.60 73 528126 393 110060707
Hypoglycaemia 182.50 10.60 171 528028 115933 109945167
Myocardial infarction 182.34 10.60 404 527795 191679 109869421
Gastric ulcer 182.30 10.60 509 527690 39318 110021782
Epistaxis 181.35 10.60 213 527986 130159 109930941
Migraine 179.64 10.60 1419 526780 170233 109890867
Oxygen saturation decreased 178.87 10.60 296 527903 156686 109904414
Mucosal inflammation 176.92 10.60 121 528078 96020 109965080
Lupus-like syndrome 176.65 10.60 511 527688 40281 110020819
Ascites 175.93 10.60 113 528086 92695 109968405
Finger deformity 175.84 10.60 447 527752 32645 110028455
Blood pressure increased 174.83 10.60 639 527560 257734 109803366
Cytomegalovirus infection 171.93 10.60 27 528172 54417 110006683
Multiple organ dysfunction syndrome 170.13 10.60 289 527910 151421 109909679
Deep vein thrombosis 168.64 10.60 254 527945 139633 109921467
Taste disorder 167.04 10.60 687 527512 64700 109996400
Adverse event 164.71 10.60 985 527214 107824 109953276
Onychomycosis 164.28 10.60 480 527719 38051 110023049
Maternal exposure timing unspecified 163.21 10.60 330 527869 20683 110040417
Dry skin 162.89 10.60 164 528035 107489 109953611
Joint dislocation 162.48 10.60 443 527756 33747 110027353
C-reactive protein increased 162.22 10.60 1673 526526 216246 109844854
Chronic obstructive pulmonary disease 162.09 10.60 169 528030 108989 109952111
Blood glucose increased 161.25 10.60 239 527960 132257 109928843
Adverse reaction 159.60 10.60 402 527797 29192 110031908
Bone erosion 158.41 10.60 535 527664 45836 110015264
Hyponatraemia 156.84 10.60 524 527675 217129 109843971
Somnolence 154.25 10.60 813 527386 296636 109764464
Drug interaction 153.48 10.60 1587 526612 498596 109562504
Agitation 152.67 10.60 189 528010 112862 109948238
Acute kidney injury 152.63 10.60 2127 526072 633303 109427797
Mental status changes 152.23 10.60 87 528112 76035 109985065
Cognitive disorder 152.09 10.60 117 528082 87394 109973706
Anti-cyclic citrullinated peptide antibody 149.71 10.60 309 527890 19655 110041445
Heart rate increased 149.63 10.60 287 527912 143547 109917553
Dyspnoea 148.88 10.60 4088 524111 1102784 108958316
Foot deformity 146.36 10.60 537 527662 47943 110013157
Plasma cell myeloma 145.59 10.60 59 528140 62877 109998223
Pregnancy 145.31 10.60 555 527644 50512 110010588
Melaena 144.19 10.60 681 527518 68076 109993024
Chills 144.15 10.60 449 527750 190131 109870969
Syncope 142.94 10.60 492 527707 202044 109859056
Full blood count abnormal 140.74 10.60 46 528153 56006 110005094
Porphyria acute 136.53 10.60 287 527912 18493 110042607
Drug resistance 135.12 10.60 50 528149 56324 110004776
Balance disorder 134.44 10.60 218 527981 116342 109944758
Neoplasm progression 131.80 10.60 72 528127 64523 109996577
Memory impairment 131.25 10.60 1479 526720 195465 109865635
Injection site pain 131.18 10.60 424 527775 177498 109883602
Neurotoxicity 128.69 10.60 23 528176 42184 110018916
Drug hypersensitivity 128.43 10.60 2955 525244 451135 109609965
Product quality issue 128.22 10.60 717 527482 76582 109984518
Chest discomfort 126.98 10.60 416 527783 173432 109887668
Encephalopathy 126.65 10.60 120 528079 80935 109980165
Bacteraemia 125.20 10.60 25 528174 42365 110018735
Dyspepsia 124.50 10.60 1428 526771 189537 109871563
Ventricular tachycardia 123.89 10.60 42 528157 49967 110011133
Device expulsion 122.35 10.60 6 528193 30885 110030215
Influenza 121.20 10.60 408 527791 168693 109892407
Tachycardia 121.12 10.60 613 527586 226032 109835068
Dysphagia 119.63 10.60 357 527842 153243 109907857
Clostridium difficile infection 118.75 10.60 50 528149 52079 110009021
Prescribed underdose 118.56 10.60 620 527579 64554 109996546
Oedema 117.71 10.60 1526 526673 208450 109852650
Hallucination 117.64 10.60 189 528010 101243 109959857
Incorrect dose administered 117.51 10.60 196 528003 103445 109957655
Seronegative arthritis 117.04 10.60 219 527980 12958 110048142
Renal failure 117.03 10.60 620 527579 225954 109835146
Kounis syndrome 116.97 10.60 143 528056 5782 110055318
Confusional state 116.58 10.60 2997 525202 465683 109595417
Hyperglycaemia 116.21 10.60 141 528058 84949 109976151
Acute myeloid leukaemia 115.70 10.60 21 528178 38089 110023011
Gastric ulcer perforation 114.94 10.60 92 528107 2196 110058904
Haemoglobin decreased 114.80 10.60 706 527493 248021 109813079
Neuroleptic malignant syndrome 114.36 10.60 14 528185 34045 110027055
Large intestinal stenosis 114.15 10.60 114 528085 3666 110057434
Cardiogenic shock 113.99 10.60 66 528133 57272 110003828
Renal impairment 112.88 10.60 489 527710 187956 109873144
Thrombosis 112.86 10.60 217 527982 108445 109952655
Muscle spasms 111.51 10.60 1908 526291 276249 109784851
Tremor 111.49 10.60 541 527658 201691 109859409
Duodenal ulcer 110.42 10.60 270 527929 19244 110041856
Coma 110.12 10.60 250 527949 117619 109943481
Breast cancer stage II 110.03 10.60 334 527865 27041 110034059
Ear infection 109.49 10.60 590 527609 62142 109998958
Pneumonia aspiration 109.48 10.60 136 528063 81097 109980003
Posterior reversible encephalopathy syndrome 108.74 10.60 16 528183 33845 110027255
Thrombotic microangiopathy 108.39 10.60 8 528191 29141 110031959
Liver function test increased 107.90 10.60 759 527440 87789 109973311
Inappropriate schedule of product administration 107.54 10.60 553 527646 203084 109858016
Drug ineffective for unapproved indication 107.13 10.60 205 527994 102633 109958467
Epilepsy 105.67 10.60 830 527369 99379 109961721
Hypervolaemia 105.56 10.60 52 528147 49408 110011692
Pulmonary fibrosis 105.31 10.60 841 527358 101201 109959899
Palpitations 104.23 10.60 399 527800 158813 109902287
Bone marrow failure 103.54 10.60 75 528124 57773 110003327
Aggression 103.09 10.60 79 528120 59131 110001969
Hypomagnesaemia 102.02 10.60 83 528116 60287 110000813
Interstitial lung disease 101.34 10.60 334 527865 139000 109922100
Pulmonary oedema 101.10 10.60 205 527994 100454 109960646
Respiratory distress 100.71 10.60 108 528091 68766 109992334
Cellulitis 99.49 10.60 291 527908 125725 109935375
Bacterial infection 98.86 10.60 48 528151 45988 110015112
Flushing 98.78 10.60 221 527978 104515 109956585
Glomerulonephritis minimal lesion 96.75 10.60 62 528137 1029 110060071
Hepatic cytolysis 96.43 10.60 73 528126 54980 110006120
Haemoptysis 95.59 10.60 120 528079 71234 109989866
Dysarthria 95.44 10.60 159 528040 83962 109977138
Generalised tonic-clonic seizure 95.15 10.60 73 528126 54607 110006493
Orthostatic hypotension 94.54 10.60 106 528093 66143 109994957
Lymphocyte count decreased 93.90 10.60 81 528118 57162 110003938
Bronchopulmonary aspergillosis 93.86 10.60 15 528184 29848 110031252
Wrong technique in product usage process 92.85 10.60 172 528027 87176 109973924
Cytopenia 92.72 10.60 16 528183 30100 110031000
Acute respiratory failure 92.30 10.60 135 528064 75125 109985975
Dyspnoea exertional 90.63 10.60 229 527970 103831 109957269
Rhinorrhoea 90.14 10.60 225 527974 102441 109958659
Blood creatinine increased 89.74 10.60 509 527690 182380 109878720
Productive cough 89.48 10.60 265 527934 114040 109947060
Diabetes mellitus 89.46 10.60 215 527984 99166 109961934
Colitis 89.25 10.60 225 527974 102098 109959002
Influenza like illness 88.85 10.60 180 528019 88232 109972868
Pulmonary arterial hypertension 88.60 10.60 23 528176 32545 110028555
Diabetic ketoacidosis 88.58 10.60 45 528154 42013 110019087
Disease recurrence 88.12 10.60 96 528103 60688 110000412
Unevaluable event 87.58 10.60 92 528107 59135 110001965
Psychotic disorder 87.37 10.60 69 528130 50868 110010232
Pericardial effusion 86.73 10.60 87 528112 57130 110003970
Pneumonitis 86.51 10.60 145 528054 76386 109984714
Nasal congestion 85.82 10.60 216 527983 98066 109963034
Large intestinal ulcer 85.73 10.60 121 528078 5640 110055460
Suicidal ideation 85.52 10.60 202 527997 93735 109967365
Transplant rejection 85.24 10.60 9 528190 24558 110036542
Hypercalcaemia 82.84 10.60 61 528138 46596 110014504
Ejection fraction decreased 82.77 10.60 46 528153 40834 110020266
Stress 82.63 10.60 244 527955 105104 109955996
Alanine aminotransferase increased 82.52 10.60 526 527673 183247 109877853
Hepatotoxicity 82.48 10.60 109 528090 63291 109997809
Depressed level of consciousness 82.44 10.60 268 527931 112010 109949090
Ventricular fibrillation 81.49 10.60 48 528151 41265 110019835
Pneumocystis jirovecii pneumonia 81.03 10.60 52 528147 42683 110018417
Status epilepticus 80.88 10.60 25 528174 31546 110029554
Haematotoxicity 80.69 10.60 5 528194 21077 110040023
Clostridium difficile colitis 80.67 10.60 55 528144 43723 110017377
Gastrooesophageal reflux disease 80.43 10.60 1257 526942 178719 109882381
Aspergillus infection 80.21 10.60 13 528186 25603 110035497
Cerebral haemorrhage 80.20 10.60 116 528083 64852 109996248
Lethargy 79.90 10.60 208 527991 93368 109967732
Periorbital oedema 79.08 10.60 160 528039 10032 110051068
Aspartate aminotransferase increased 79.07 10.60 444 527755 159492 109901608
Feeling abnormal 78.72 10.60 522 527677 180189 109880911
Hepatic cirrhosis 78.52 10.60 573 527626 67053 109994047
Red blood cell sedimentation rate increased 78.43 10.60 641 527558 77661 109983439
Unresponsive to stimuli 76.69 10.60 116 528083 63674 109997426
Cholestasis 75.96 10.60 119 528080 64399 109996701
Weight decreased 75.59 10.60 1681 526518 466376 109594724
Right ventricular failure 75.22 10.60 16 528183 25938 110035162
Herpes zoster 74.60 10.60 266 527933 108113 109952987
Device related infection 73.69 10.60 49 528150 39470 110021630
Sacroiliitis 73.26 10.60 104 528095 4874 110056226
Joint stiffness 72.57 10.60 560 527639 66683 109994417
Bronchiectasis 72.55 10.60 42 528157 36451 110024649
Hepatic failure 72.49 10.60 136 528063 68603 109992497
Obstructive airways disorder 72.47 10.60 68 528131 46081 110015019
Neutropenic sepsis 72.46 10.60 28 528171 30718 110030382
Sedation complication 72.28 10.60 6 528193 19849 110041251
Multiple sclerosis relapse 72.11 10.60 80 528119 50160 110010940
Torsade de pointes 71.83 10.60 11 528188 22589 110038511
Vision blurred 71.76 10.60 344 527855 128678 109932422
International normalised ratio increased 71.72 10.60 196 528003 86576 109974524
Progressive multifocal leukoencephalopathy 71.08 10.60 16 528183 24940 110036160
Blood test abnormal 70.70 10.60 24 528175 28530 110032570
Respiratory arrest 70.10 10.60 106 528093 58193 110002907
Device dislocation 69.70 10.60 32 528167 31672 110029428
Chronic sinusitis 69.62 10.60 17 528182 25067 110036033
Infusion site reaction 69.44 10.60 214 527985 17468 110043632
Candida infection 69.40 10.60 76 528123 47933 110013167
Ulcer haemorrhage 68.95 10.60 251 527948 22320 110038780
Blood pressure fluctuation 68.84 10.60 160 528039 74664 109986436
Pyrexia 68.81 10.60 3548 524651 894717 109166383
Skin exfoliation 68.75 10.60 203 527996 87448 109973652
Therapy interrupted 68.62 10.60 82 528117 49740 110011360
Deafness transitory 68.20 10.60 50 528149 1043 110060057
Depressed mood 68.00 10.60 116 528083 60693 110000407
Haemorrhage 67.51 10.60 271 527928 106421 109954679
Sinus disorder 67.47 10.60 36 528163 32692 110028408
Paraesthesia 67.42 10.60 1764 526435 274757 109786343
Febrile bone marrow aplasia 67.27 10.60 4 528195 17461 110043639
Myalgia 67.10 10.60 708 527491 221673 109839427
Lymphopenia 66.92 10.60 56 528143 40114 110020986
Device issue 66.89 10.60 41 528158 34494 110026606
Extrapyramidal disorder 66.86 10.60 27 528172 28840 110032260
Procedural pain 66.45 10.60 44 528155 35521 110025579
Injection site swelling 66.27 10.60 121 528078 61669 109999431
Walking aid user 66.05 10.60 266 527933 24809 110036291
Gastritis erosive 65.74 10.60 164 528035 11836 110049264
Myasthenia gravis 64.98 10.60 12 528187 21499 110039601
Hypocalcaemia 64.89 10.60 134 528065 65232 109995868
Blood bilirubin increased 64.76 10.60 169 528030 75803 109985297
Haemophagocytic lymphohistiocytosis 64.64 10.60 35 528164 31524 110029576
Transaminases increased 64.60 10.60 128 528071 63262 109997838
Pruritus 64.58 10.60 3396 524803 578164 109482936
Enterococcal infection 64.53 10.60 10 528189 20356 110040744
Schizophrenia 64.19 10.60 13 528186 21813 110039287
Drug dependence 64.04 10.60 87 528112 49933 110011167
Transfusion 63.78 10.60 21 528178 25451 110035649
Acute respiratory distress syndrome 63.70 10.60 97 528102 53101 110007999
Rhabdomyolysis 62.96 10.60 328 527871 120073 109941027
Vascular device infection 62.95 10.60 4 528195 16508 110044592
Urosepsis 62.86 10.60 34 528165 30641 110030459
Respiratory tract infection 62.83 10.60 157 528042 71460 109989640
Therapy cessation 62.67 10.60 73 528126 44784 110016316
Treatment noncompliance 62.50 10.60 162 528037 72828 109988272
Fungal infection 62.43 10.60 91 528108 50715 110010385
Injection site erythema 62.28 10.60 235 527964 93941 109967159
Hypophosphataemia 62.06 10.60 41 528158 33141 110027959
Bladder cancer 61.99 10.60 11 528188 20281 110040819
Tumour lysis syndrome 61.87 10.60 35 528164 30766 110030334
Basal cell carcinoma 61.83 10.60 75 528124 45195 110015905
Throat irritation 60.95 10.60 101 528098 53451 110007649
Hypothyroidism 60.75 10.60 164 528035 72735 109988365
Respiratory tract congestion 60.65 10.60 36 528163 30821 110030279
Atelectasis 60.15 10.60 52 528147 36660 110024440
Akathisia 60.07 10.60 6 528193 17107 110043993
Intestinal obstruction 60.01 10.60 101 528098 53126 110007974
Ischaemic stroke 60.00 10.60 65 528134 41198 110019902
Psoriasis 59.62 10.60 970 527229 139023 109922077
Metabolic acidosis 59.60 10.60 259 527940 99485 109961615
Abnormal behaviour 59.59 10.60 59 528140 38980 110022120
Dysgeusia 59.41 10.60 156 528043 69829 109991271
Aphasia 59.37 10.60 120 528079 58877 110002223
Pulmonary mass 58.53 10.60 55 528144 37246 110023854
Arrhythmia 58.37 10.60 156 528043 69419 109991681
Aspirin-exacerbated respiratory disease 58.32 10.60 43 528156 905 110060195
Troponin increased 58.12 10.60 35 528164 29731 110031369
Adverse drug reaction 57.79 10.60 764 527435 104795 109956305
Drug-induced liver injury 57.26 10.60 848 527351 119219 109941881
Pulmonary alveolar haemorrhage 57.22 10.60 13 528186 20137 110040963
Drug tolerance decreased 57.17 10.60 272 527927 27268 110033832
Palmar-plantar erythrodysaesthesia syndrome 57.06 10.60 67 528132 40958 110020142
Second primary malignancy 56.96 10.60 9 528190 18059 110043041
Subcutaneous drug absorption impaired 56.78 10.60 118 528081 7541 110053559
Blood potassium decreased 56.24 10.60 108 528091 54006 110007094
Appendicitis 56.24 10.60 33 528166 28431 110032669
Red blood cell count decreased 55.92 10.60 147 528052 65776 109995324
Haematocrit decreased 55.65 10.60 148 528051 65969 109995131
Loss of consciousness 55.62 10.60 634 527565 195672 109865428
Hospitalisation 55.53 10.60 425 527774 142068 109919032
Diabetes mellitus inadequate control 55.41 10.60 37 528162 29738 110031362
Cardiac disorder 55.35 10.60 183 528016 76097 109985003
Erythema 55.29 10.60 1019 527180 290428 109770672
Osteonecrosis of jaw 55.17 10.60 90 528109 47927 110013173
Hypertension 55.08 10.60 2971 525228 507113 109553987
Blood calcium increased 54.63 10.60 10 528189 18030 110043070
Metastases to liver 54.56 10.60 53 528146 35333 110025767
Proctitis 54.35 10.60 8 528191 16919 110044181
Hepatic encephalopathy 54.09 10.60 34 528165 28222 110032878
Blood calcium decreased 53.76 10.60 55 528144 35790 110025310
Myocarditis 53.74 10.60 39 528160 30016 110031084
Immune reconstitution inflammatory syndrome 53.67 10.60 7 528192 16219 110044881
Accidental exposure to product 53.56 10.60 98 528101 49910 110011190
Neutrophil count increased 53.31 10.60 52 528147 34600 110026500
Hypogammaglobulinaemia 53.07 10.60 15 528184 20061 110041039
Acute myocardial infarction 52.87 10.60 213 527986 83564 109977536
Drug use disorder 52.67 10.60 11 528188 18063 110043037
Female genital tract fistula 52.59 10.60 8 528191 16511 110044589
Serotonin syndrome 52.42 10.60 129 528070 59024 110002076
Cardiac murmur 52.39 10.60 26 528173 24602 110036498
COVID-19 pneumonia 52.37 10.60 60 528139 37083 110024017
Infective pulmonary exacerbation of cystic fibrosis 52.32 10.60 5 528194 14766 110046334
Agranulocytosis 52.17 10.60 138 528061 61622 109999478
Electrolyte imbalance 52.01 10.60 60 528139 36968 110024132
Premature delivery 51.90 10.60 42 528157 30590 110030510
Dementia 51.73 10.60 45 528154 31628 110029472
Hemiplegia 51.65 10.60 22 528177 22760 110038340
Subdural haematoma 51.28 10.60 59 528140 36395 110024705
Complication associated with device 51.23 10.60 16 528183 20057 110041043
Staphylococcal bacteraemia 51.08 10.60 9 528190 16679 110044421
Injection site pruritus 50.95 10.60 105 528094 51153 110009947
Full blood count decreased 50.75 10.60 47 528152 32052 110029048
Pancreatitis acute 50.67 10.60 135 528064 60139 110000961
Disability 50.54 10.60 281 527918 29942 110031158
Grip strength 50.15 10.60 125 528074 9016 110052084
Spondylitis 50.02 10.60 143 528056 11195 110049905
Hypernatraemia 49.66 10.60 12 528187 17821 110043279
Transient ischaemic attack 48.87 10.60 150 528049 63832 109997268
Eczema 48.71 10.60 179 528020 72114 109988986
Dysuria 48.33 10.60 138 528061 60093 110001007
Multiple-drug resistance 48.18 10.60 4 528195 13231 110047869
Amnesia 47.76 10.60 738 527461 104670 109956430
Altered state of consciousness 47.74 10.60 130 528069 57496 110003604
Ataxia 47.71 10.60 44 528155 30064 110031036
Oral candidiasis 47.69 10.60 88 528111 44672 110016428
Injection site bruising 47.65 10.60 109 528090 51154 110009946
Angina pectoris 47.62 10.60 146 528053 62149 109998951
Myelodysplastic syndrome 47.18 10.60 66 528133 37418 110023682
Paranoia 47.03 10.60 24 528175 22350 110038750
Gastrointestinal erosion 46.97 10.60 41 528158 1107 110059993
Sinus bradycardia 46.82 10.60 43 528156 29440 110031660
Acute graft versus host disease 46.59 10.60 4 528195 12877 110048223
Liver function test abnormal 46.28 10.60 171 528028 68779 109992321
Abdominal pain 46.19 10.60 1991 526208 510998 109550102
Disturbance in attention 46.18 10.60 147 528052 61848 109999252
Pulmonary hypertension 46.18 10.60 124 528075 55096 110006004
Hemiparesis 46.17 10.60 87 528112 43816 110017284
Respiratory symptom 45.88 10.60 8 528191 14937 110046163
Small intestine ulcer 45.85 10.60 36 528163 835 110060265
Vertigo 45.78 10.60 236 527963 86634 109974466
Metastases to central nervous system 45.73 10.60 26 528173 22791 110038309
Hyperphosphataemia 45.66 10.60 11 528188 16370 110044730
Nasal polyps 45.38 10.60 5 528194 13195 110047905
Breath sounds abnormal 45.38 10.60 33 528166 25371 110035729
Accidental overdose 45.18 10.60 114 528085 51720 110009380
Sensory loss 45.12 10.60 23 528176 21434 110039666
Oral pain 45.10 10.60 68 528131 37376 110023724
Therapy partial responder 44.93 10.60 67 528132 36994 110024106
Drug level increased 44.73 10.60 101 528098 47618 110013482
Swelling face 44.70 10.60 258 527941 92063 109969037
Failure to thrive 44.56 10.60 6 528193 13568 110047532
Vaginal discharge 44.43 10.60 15 528184 17893 110043207
Cardiomyopathy 44.26 10.60 57 528142 33468 110027632
Viral infection 43.93 10.60 120 528079 53019 110008081
Atrioventricular block 43.89 10.60 13 528186 16864 110044236
Diffuse large B-cell lymphoma 43.69 10.60 11 528188 15887 110045213
Drug level decreased 43.53 10.60 17 528182 18531 110042569
Parkinsonism 43.45 10.60 26 528173 22161 110038939
Pneumonia bacterial 43.27 10.60 37 528162 26224 110034876
Peripheral sensory neuropathy 43.10 10.60 13 528186 16667 110044433
Immune effector cell-associated neurotoxicity syndrome 43.07 10.60 9 528190 14773 110046327
Hyperammonaemia 42.93 10.60 7 528192 13725 110047375
Sputum discoloured 42.92 10.60 42 528157 27903 110033197
Swollen joint count 42.83 10.60 114 528085 8560 110052540
Cholelithiasis 42.76 10.60 157 528042 63265 109997835
Injection site haemorrhage 42.74 10.60 57 528142 32971 110028129
Hyperthyroidism 42.65 10.60 46 528153 29215 110031885
Epstein-Barr virus infection 42.63 10.60 18 528181 18720 110042380
Anaphylactic reaction 42.52 10.60 775 527424 113525 109947575
Inspiratory capacity decreased 42.37 10.60 57 528142 2538 110058562
Small intestinal obstruction 42.29 10.60 55 528144 32158 110028942
End stage renal disease 42.28 10.60 25 528174 21448 110039652
Blood glucose decreased 42.27 10.60 47 528152 29441 110031659
Hypothermia 42.20 10.60 38 528161 26264 110034836
Electrocardiogram QRS complex prolonged 42.16 10.60 6 528193 13015 110048085
Osteoporosis 42.13 10.60 617 527582 86535 109974565
Hypocholesterolaemia 41.96 10.60 94 528105 6327 110054773
Dysphonia 41.89 10.60 203 527996 75726 109985374
Subarachnoid haemorrhage 41.86 10.60 48 528151 29654 110031446
Rales 41.81 10.60 34 528165 24705 110036395
Normal newborn 41.69 10.60 211 527988 21685 110039415
No adverse event 41.56 10.60 196 528003 73643 109987457
Exposure to toxic agent 41.46 10.60 6 528193 12852 110048248
Immunosuppressant drug level increased 41.44 10.60 4 528195 11720 110049380
Oligohydramnios 41.39 10.60 71 528128 3923 110057177
Cataract 41.29 10.60 217 527982 79268 109981832
Bronchitis 41.09 10.60 516 527683 156516 109904584
Staphylococcal infection 40.95 10.60 183 528016 69761 109991339
Salivary hypersecretion 40.83 10.60 16 528183 17405 110043695
Psychomotor hyperactivity 40.79 10.60 23 528176 20254 110040846
Device occlusion 40.78 10.60 11 528188 15174 110045926
Impaired quality of life 40.71 10.60 50 528149 29967 110031133
Haematuria 40.71 10.60 231 527968 82774 109978326
Dystonia 40.55 10.60 38 528161 25767 110035333
Injection site necrosis 40.47 10.60 46 528153 1720 110059380
Hyperlipidaemia 40.44 10.60 68 528131 35780 110025320
Gastric ulcer haemorrhage 40.42 10.60 123 528076 9971 110051129
Chronic kidney disease 40.35 10.60 207 527992 76084 109985016
Gastrointestinal procedural complication 40.19 10.60 26 528173 439 110060661
Aortic stenosis 40.07 10.60 7 528192 13052 110048048
Adjustment disorder 40.03 10.60 3 528196 10792 110050308
Coronary artery disease 39.94 10.60 191 528008 71499 109989601
Pulseless electrical activity 39.92 10.60 15 528184 16742 110044358
Myoclonus 39.67 10.60 60 528139 32938 110028162
Malnutrition 39.63 10.60 43 528156 27236 110033864
Motor dysfunction 39.47 10.60 35 528164 24371 110036729
Pseudomonas infection 39.26 10.60 45 528154 27808 110033292
Rebound effect 39.25 10.60 11 528188 14795 110046305
Rhinovirus infection 39.20 10.60 5 528194 11784 110049316
Macular degeneration 38.86 10.60 28 528171 21631 110039469
Delirium 38.79 10.60 881 527318 134144 109926956
Cystitis haemorrhagic 38.67 10.60 6 528193 12203 110048897
Granulocytopenia 38.61 10.60 7 528192 12708 110048392
Haemorrhage intracranial 38.51 10.60 49 528150 28920 110032180
Euglycaemic diabetic ketoacidosis 38.48 10.60 5 528194 11618 110049482
Blood phosphorus increased 38.31 10.60 15 528184 16325 110044775
Endoscopy abnormal 38.22 10.60 13 528186 41 110061059
Hypertensive crisis 38.16 10.60 36 528163 24336 110036764
Hot flush 37.93 10.60 174 528025 65862 109995238
Sinus tachycardia 37.90 10.60 99 528100 44394 110016706
Type I hypersensitivity 37.82 10.60 90 528109 6303 110054797
Heart rate irregular 37.76 10.60 66 528133 34208 110026892
Activated partial thromboplastin time prolonged 37.48 10.60 31 528168 22337 110038763
Tonsillar ulcer 37.45 10.60 25 528174 446 110060654
Atrioventricular block complete 37.31 10.60 25 528174 20057 110041043
Device leakage 37.19 10.60 15 528184 16033 110045067
Arteriosclerosis coronary artery 37.15 10.60 39 528160 25079 110036021
Catatonia 37.08 10.60 5 528194 11295 110049805
Pathogen resistance 37.08 10.60 19 528180 17653 110043447
Drug withdrawal syndrome 36.94 10.60 79 528120 37975 110023125
Eosinophilic granulomatosis with polyangiitis 36.86 10.60 4 528195 10682 110050418
Atrial flutter 36.65 10.60 37 528162 24225 110036875
Forced expiratory volume decreased 36.43 10.60 9 528190 13167 110047933
Dyskinesia 36.25 10.60 125 528074 51321 110009779
Feeling cold 36.05 10.60 67 528132 33920 110027180
Bone pain 36.01 10.60 174 528025 64959 109996141
Respiratory depression 35.82 10.60 61 528138 31940 110029160
Proteinuria 35.67 10.60 87 528112 39931 110021169
Sopor 35.37 10.60 76 528123 36470 110024630
Undifferentiated connective tissue disease 35.35 10.60 19 528180 223 110060877
Vasculitis 35.22 10.60 74 528125 35799 110025301
Heart rate decreased 35.05 10.60 241 527958 82515 109978585
Partial seizures 35.00 10.60 6 528193 11343 110049757
Presyncope 34.98 10.60 118 528081 48769 110012331
Hepatic function abnormal 34.94 10.60 266 527933 89029 109972071
Cardiac failure acute 34.93 10.60 38 528161 24040 110037060
Eosinophilia 34.88 10.60 150 528049 57786 110003314
Tachypnoea 34.84 10.60 86 528113 39309 110021791
Wrist deformity 34.78 10.60 58 528141 3131 110057969
Cross sensitivity reaction 34.71 10.60 80 528119 5487 110055613
Aplasia pure red cell 34.58 10.60 3 528196 9575 110051525
Drug dose omission by device 34.57 10.60 13 528186 14503 110046597
Muscular weakness 34.54 10.60 1484 526715 246984 109814116
Neoplasm malignant 34.50 10.60 79 528120 37064 110024036
Aspiration 34.36 10.60 58 528141 30475 110030625
Localised infection 34.26 10.60 99 528100 42949 110018151
Abortion spontaneous 34.26 10.60 70 528129 34212 110026888
Device difficult to use 34.15 10.60 24 528175 18781 110042319
Nervous system disorder 34.12 10.60 62 528137 31659 110029441
Coagulopathy 34.11 10.60 92 528107 40819 110020281
Pulmonary haemorrhage 34.07 10.60 18 528181 16438 110044662
Cardiomegaly 34.03 10.60 54 528145 29076 110032024
Pustular psoriasis 33.99 10.60 142 528057 13463 110047637
Renal cancer 33.97 10.60 10 528189 13024 110048076
Ductus arteriosus stenosis foetal 33.96 10.60 15 528184 110 110060990
Terminal insomnia 33.85 10.60 44 528155 1894 110059206
Panniculitis 33.83 10.60 16 528183 15566 110045534
Systemic candida 33.73 10.60 4 528195 9970 110051130
Blood triglycerides increased 33.35 10.60 39 528160 23887 110037213
Blindness 33.24 10.60 78 528121 36281 110024819
Skin fissures 32.89 10.60 41 528158 24417 110036683
Lacrimation increased 32.84 10.60 61 528138 30889 110030211
Arterial occlusive disease 32.81 10.60 16 528183 15292 110045808
Incorrect route of product administration 32.74 10.60 458 527741 63603 109997497
Cardiac tamponade 32.71 10.60 7 528192 11300 110049800
Eye pruritus 32.69 10.60 67 528132 32708 110028392
Overdose 32.64 10.60 858 527341 232936 109828164
Haemolysis 32.54 10.60 17 528182 15622 110045478
Squamous cell carcinoma of skin 32.52 10.60 21 528178 17182 110043918
Blood parathyroid hormone decreased 32.41 10.60 11 528188 13078 110048022
Device use error 32.40 10.60 3 528196 9086 110052014
Glycosylated haemoglobin increased 32.39 10.60 39 528160 23580 110037520
Duodenal ulcer haemorrhage 32.24 10.60 98 528101 7939 110053161
Foetal death 32.24 10.60 157 528042 15888 110045212
Lung neoplasm malignant 32.24 10.60 71 528128 33771 110027329
Mania 32.23 10.60 31 528168 20765 110040335
Radiculopathy 32.15 10.60 27 528172 19309 110041791
Pulmonary thrombosis 32.05 10.60 13 528186 13850 110047250
Disorientation 31.85 10.60 202 527997 70469 109990631
Immunosuppression 31.81 10.60 23 528176 17736 110043364
Intestinal ulcer 31.80 10.60 48 528151 2379 110058721
Renal failure neonatal 31.75 10.60 13 528186 77 110061023
Hallucination, auditory 31.73 10.60 48 528151 26349 110034751
Unintentional medical device removal 31.66 10.60 3 528196 8920 110052180
Tinnitus 31.60 10.60 165 528034 60375 110000725
Oropharyngeal pain 31.59 10.60 455 527744 134821 109926279
Peritonitis bacterial 31.55 10.60 6 528193 10527 110050573
Spinal pain 31.53 10.60 173 528026 18342 110042758
Rash maculo-papular 31.51 10.60 216 527983 74006 109987094
Coordination abnormal 31.18 10.60 45 528154 25183 110035917
Emphysema 31.15 10.60 29 528170 19727 110041373
Analgesic drug level above therapeutic 31.12 10.60 23 528176 486 110060614
Fear 31.07 10.60 39 528160 23154 110037946
Creatinine renal clearance decreased 31.02 10.60 35 528164 21780 110039320
Lymphatic fistula 31.01 10.60 37 528162 1458 110059642
Heavy menstrual bleeding 30.91 10.60 20 528179 16345 110044755
Benign prostatic hyperplasia 30.89 10.60 25 528174 18209 110042891
Skin toxicity 30.78 10.60 9 528190 11774 110049326
Pneumonia fungal 30.75 10.60 16 528183 14738 110046362
Product storage error 30.74 10.60 35 528164 21693 110039407
Femoral hernia incarcerated 30.73 10.60 37 528162 1472 110059628
Delusion 30.73 10.60 41 528158 23714 110037386
Haemorrhoids 30.67 10.60 79 528120 35593 110025507
Neonatal respiratory acidosis 30.65 10.60 12 528187 62 110061038
Acne 30.57 10.60 72 528127 33448 110027652
Encephalitis 30.48 10.60 27 528172 18812 110042288
Myopathy 30.38 10.60 45 528154 24915 110036185
Corneal epithelium defect 30.33 10.60 29 528170 883 110060217
Cystitis 30.15 10.60 188 528011 65848 109995252
Sleep apnoea syndrome 30.06 10.60 96 528103 40351 110020749
Breast cancer female 29.97 10.60 11 528188 12457 110048643
Pneumatosis intestinalis 29.91 10.60 3 528196 8526 110052574
Synovial cyst 29.90 10.60 121 528078 11309 110049791
Ligament calcification 29.86 10.60 17 528182 225 110060875
Brain oedema 29.82 10.60 65 528134 31033 110030067
Hepatic enzyme 29.81 10.60 72 528127 5091 110056009
Sinus congestion 29.76 10.60 63 528136 30396 110030704
Eosinophil count increased 29.71 10.60 34 528165 21024 110040076
Haematochezia 29.70 10.60 381 527818 115143 109945957
Anxiety 29.65 10.60 1346 526853 343732 109717368
Haematoma 29.62 10.60 161 528038 58315 110002785
Toxic encephalopathy 29.55 10.60 18 528181 15196 110045904
Bronchopulmonary aspergillosis allergic 29.46 10.60 3 528196 8423 110052677
Hallucination, visual 29.44 10.60 94 528105 39511 110021589
Lung infiltration 29.40 10.60 45 528154 24583 110036517
Paraesthesia oral 29.39 10.60 74 528125 33597 110027503
Hip fracture 29.34 10.60 79 528120 35072 110026028
Rash macular 29.33 10.60 91 528108 38595 110022505
Spinal stenosis 29.13 10.60 173 528026 18883 110042217
Urinary incontinence 29.12 10.60 126 528073 48461 110012639
Upper-airway cough syndrome 29.11 10.60 20 528179 15837 110045263
Haemodynamic instability 29.11 10.60 40 528159 22848 110038252
Tongue disorder 29.07 10.60 16 528183 14282 110046818
Glomerular filtration rate decreased 29.05 10.60 59 528140 28897 110032203
Cerebral infarction 28.94 10.60 138 528061 51700 110009400
Sneezing 28.93 10.60 69 528130 31915 110029185
Intestinal ischaemia 28.92 10.60 21 528178 16158 110044942
Medication error 28.87 10.60 683 527516 104683 109956417
Hyperlactacidaemia 28.84 10.60 3 528196 8283 110052817
Anal fissure 28.82 10.60 6 528193 9875 110051225
Klebsiella infection 28.56 10.60 32 528167 19977 110041123
Diverticulitis 28.43 10.60 145 528054 53377 110007723
Anosmia 28.34 10.60 12 528187 12460 110048640
Injection site scab 28.32 10.60 24 528175 622 110060478
Emotional distress 28.31 10.60 114 528085 44733 110016367
Neurological symptom 28.24 10.60 20 528179 15588 110045512
Ulcer 28.24 10.60 108 528091 43008 110018092
Hypomania 28.18 10.60 7 528192 10203 110050897
Cholangitis 28.17 10.60 22 528177 16313 110044787
Insomnia 28.09 10.60 2042 526157 358548 109702552
Squamous cell carcinoma 28.07 10.60 28 528171 18435 110042665
Eye irritation 28.06 10.60 75 528124 33377 110027723
Bradycardia neonatal 28.00 10.60 12 528187 81 110061019
Oesophageal carcinoma 27.99 10.60 10 528189 11514 110049586
Blood pressure decreased 27.97 10.60 384 527815 114707 109946393
Blood creatine phosphokinase increased 27.97 10.60 219 527980 72858 109988242
Neutropenic colitis 27.86 10.60 3 528196 8062 110053038
Supraventricular tachycardia 27.85 10.60 46 528153 24376 110036724
Angioedema 27.76 10.60 641 527558 97859 109963241
Inappropriate antidiuretic hormone secretion 27.57 10.60 77 528122 33774 110027326
Prostate cancer 27.52 10.60 90 528109 37551 110023549
Sexual dysfunction 27.46 10.60 4 528195 8526 110052574
Pseudomonal sepsis 27.42 10.60 5 528194 9041 110052059
Diplopia 27.40 10.60 105 528094 41789 110019311
Atrioventricular block first degree 27.39 10.60 17 528182 14208 110046892
Anaphylactic shock 27.35 10.60 371 527828 51175 110009925
Syringe issue 27.34 10.60 6 528193 9519 110051581
Shoulder arthroplasty 27.24 10.60 56 528143 3551 110057549
Fat necrosis 27.20 10.60 28 528171 934 110060166
Therapy non-responder 27.15 10.60 962 527237 156345 109904755
Skin ulcer 27.12 10.60 185 528014 63460 109997640
Intentional overdose 27.10 10.60 457 527742 132044 109929056
Upper limb fracture 27.08 10.60 36 528163 20852 110040248
Drug eruption 27.03 10.60 148 528051 53511 110007589
Aplasia 27.02 10.60 3 528196 7870 110053230
Gastroduodenal ulcer 26.98 10.60 28 528171 943 110060157
Lymphadenopathy 26.98 10.60 186 528013 63649 109997451
Cyanosis neonatal 26.89 10.60 11 528188 65 110061035
Central nervous system lesion 26.76 10.60 21 528178 15532 110045568
Application site eczema 26.69 10.60 7 528192 5 110061095
Thinking abnormal 26.61 10.60 20 528179 15120 110045980
Tardive dyskinesia 26.47 10.60 16 528183 13563 110047537
Hypovolaemia 26.45 10.60 39 528160 21635 110039465
Fractional exhaled nitric oxide increased 26.43 10.60 25 528174 751 110060349
Blood pressure systolic increased 26.34 10.60 261 527938 82730 109978370
Rheumatoid nodule 26.29 10.60 35 528164 20261 110040839
Pleuritic pain 26.27 10.60 23 528176 16117 110044983
Metastases to lymph nodes 26.24 10.60 20 528179 15012 110046088
Temperature regulation disorder 26.13 10.60 126 528073 12700 110048400
Skin infection 26.04 10.60 42 528157 22467 110038633
Multiple allergies 26.00 10.60 13 528186 12250 110048850
Nodule 26.00 10.60 75 528124 32556 110028544
Skin discolouration 25.98 10.60 133 528066 48913 110012187
Heparin-induced thrombocytopenia 25.95 10.60 11 528188 11413 110049687
Atrial tachycardia 25.91 10.60 6 528193 9172 110051928
Behaviour disorder 25.89 10.60 7 528192 9640 110051460
Injection site rash 25.88 10.60 45 528154 23374 110037726
Hypersomnia 25.81 10.60 60 528139 28001 110033099
Drug ineffective 25.71 10.60 6664 521535 1513876 108547224
Sarcoidosis 25.69 10.60 14 528185 12565 110048535
Hepatitis C 25.67 10.60 14 528185 12559 110048541
Gout 25.66 10.60 89 528110 36477 110024623
Hyperbilirubinaemia 25.55 10.60 69 528130 30602 110030498
Hypophagia 25.51 10.60 147 528052 52479 110008621
Ventricular extrasystoles 25.49 10.60 43 528156 22598 110038502
Mental impairment 25.48 10.60 43 528156 22596 110038504
Sickle cell anaemia with crisis 25.47 10.60 7 528192 9538 110051562
Cushingoid 25.47 10.60 12 528187 11700 110049400
Underdose 25.44 10.60 436 527763 63118 109997982
Ear pain 25.40 10.60 376 527823 52850 110008250
Hiccups 25.31 10.60 15 528184 12854 110048246
Exercise tolerance decreased 25.28 10.60 13 528186 12054 110049046
Alcohol poisoning 25.26 10.60 6 528193 9014 110052086
Speech disorder 25.24 10.60 181 528018 61388 109999712
General symptom 25.04 10.60 96 528103 8750 110052350
Lymphocyte stimulation test positive 25.04 10.60 28 528171 1028 110060072
Herpes simplex 25.02 10.60 23 528176 15741 110045359
Loss of personal independence in daily activities 24.97 10.60 536 527663 149484 109911616
Vomiting 24.94 10.60 3894 524305 906781 109154319
Organising pneumonia 24.80 10.60 19 528180 14224 110046876
Paradoxical drug reaction 24.74 10.60 8 528191 9809 110051291
Hyperkalaemia 24.74 10.60 478 527721 135318 109925782
Brain injury 24.73 10.60 17 528182 13459 110047641
Alanine aminotransferase abnormal 24.62 10.60 7 528192 9327 110051773
Complications of intestinal transplant 24.59 10.60 8 528191 21 110061079
Dyspnoea at rest 24.48 10.60 5 528194 8341 110052759
Fracture 24.45 10.60 51 528148 24737 110036363
Rotator cuff repair 24.43 10.60 41 528158 2225 110058875
Rhinitis 24.31 10.60 44 528155 22501 110038599
Soft tissue injury 24.30 10.60 41 528158 2235 110058865
Hypopnoea 24.23 10.60 12 528187 11368 110049732
Leukocytosis 24.18 10.60 154 528045 53674 110007426
Renal disorder 24.10 10.60 138 528061 49341 110011759
Ketoacidosis 24.08 10.60 9 528190 10078 110051022
Gastric haemorrhage 24.02 10.60 144 528055 15771 110045329
Irritability 24.01 10.60 132 528067 47677 110013423
Escherichia urinary tract infection 24.01 10.60 25 528174 16137 110044963
Jejunal ulcer 23.99 10.60 15 528184 238 110060862
Pulmonary function test decreased 23.94 10.60 6 528193 8694 110052406
Left ventricular hypertrophy 23.92 10.60 17 528182 13227 110047873
Sleep disorder due to general medical condition, hypersomnia type 23.76 10.60 38 528161 1981 110059119
Skin cancer 23.72 10.60 30 528169 17754 110043346
Mastoid abscess 23.68 10.60 6 528193 3 110061097
Urine abnormality 23.67 10.60 7 528192 9089 110052011
Ventricular hypokinesia 23.61 10.60 12 528187 11202 110049898
Carbuncle 23.61 10.60 32 528167 1435 110059665
Toxic skin eruption 23.60 10.60 61 528138 27454 110033646
Multiple sclerosis 23.59 10.60 55 528144 25643 110035457
Peptic ulcer 23.50 10.60 85 528114 7534 110053566
Breast cancer metastatic 23.49 10.60 12 528187 11169 110049931
Fistula 23.49 10.60 23 528176 15276 110045824
Central pain syndrome 23.43 10.60 24 528175 796 110060304
Cytomegalovirus test positive 23.36 10.60 3 528196 7033 110054067
Pollakiuria 23.32 10.60 120 528079 44075 110017025
Cardiac failure chronic 23.32 10.60 19 528180 13792 110047308
Embolism 23.31 10.60 26 528173 16263 110044837
Bedridden 23.26 10.60 18 528181 13407 110047693
Spinal fusion surgery 23.22 10.60 96 528103 9060 110052040
Paronychia 23.12 10.60 12 528187 11069 110050031
Multiple drug therapy 23.10 10.60 5 528194 8009 110053091
Flatulence 23.02 10.60 150 528049 51999 110009101
Hepatitis B reactivation 22.99 10.60 4 528195 7480 110053620
Hypertriglyceridaemia 22.88 10.60 26 528173 16128 110044972
Blood pressure diastolic decreased 22.79 10.60 91 528108 35794 110025306
Restlessness 22.77 10.60 166 528033 56093 110005007
Product dose omission in error 22.67 10.60 49 528150 23463 110037637
Functional gastrointestinal disorder 22.64 10.60 72 528127 5977 110055123
Complication of device insertion 22.64 10.60 7 528192 8831 110052269
Head injury 22.59 10.60 117 528082 42900 110018200
Gestational diabetes 22.58 10.60 4 528195 7385 110053715
Sudden death 22.57 10.60 52 528147 24343 110036757
Lower respiratory tract infection viral 22.54 10.60 31 528168 1410 110059690
Breast cancer 22.46 10.60 101 528098 38441 110022659
Ventricular arrhythmia 22.46 10.60 10 528189 10077 110051023
Pancreatic steatosis 22.42 10.60 35 528164 1787 110059313
Lung opacity 22.33 10.60 14 528185 11638 110049462
Tension headache 22.27 10.60 9 528190 9609 110051491
Embolic stroke 22.26 10.60 7 528192 8736 110052364
Stupor 22.17 10.60 6 528193 8259 110052841
SARS-CoV-2 test positive 22.14 10.60 29 528170 16906 110044194
Caesarean section 22.12 10.60 20 528179 13797 110047303
Carotid artery occlusion 22.07 10.60 9 528190 9556 110051544
Axial spondyloarthritis 22.06 10.60 24 528175 854 110060246
Generalised oedema 22.04 10.60 74 528125 30630 110030470
Hydrocephalus 22.00 10.60 11 528188 10364 110050736
Tooth disorder 21.96 10.60 70 528129 29439 110031661
Tissue infiltration 21.94 10.60 26 528173 1017 110060083
Needle issue 21.87 10.60 32 528167 17808 110043292
Intentional self-injury 21.87 10.60 98 528101 37331 110023769
Gallbladder disorder 21.82 10.60 42 528157 20987 110040113
Skin laceration 21.81 10.60 85 528114 33668 110027432
Gynaecomastia 21.78 10.60 9 528190 9481 110051619
Eyelid ptosis 21.68 10.60 19 528180 13308 110047792
Device malfunction 21.67 10.60 57 528142 25501 110035599
Infusion site pain 21.60 10.60 31 528168 17388 110043712
Restless legs syndrome 21.59 10.60 54 528145 24572 110036528
Dissociation 21.53 10.60 10 528189 9832 110051268
Cytomegalovirus chorioretinitis 21.48 10.60 4 528195 7124 110053976
Post procedural complication 21.44 10.60 61 528138 26597 110034503
Affect lability 21.35 10.60 35 528164 18602 110042498
Hospice care 21.26 10.60 17 528182 12456 110048644
Escherichia bacteraemia 21.22 10.60 11 528188 10153 110050947
Toothache 21.21 10.60 51 528148 23524 110037576
Psychomotor skills impaired 21.19 10.60 4 528195 7054 110054046
Hepatocellular injury 21.19 10.60 148 528051 50494 110010606
Rash vesicular 21.12 10.60 131 528068 14521 110046579
Ileal ulcer 21.11 10.60 34 528165 1783 110059317
Catheter site infection 21.10 10.60 6 528193 7994 110053106
Gastrointestinal ulcer 21.04 10.60 56 528143 4204 110056896
Pancreatic carcinoma 20.99 10.60 24 528175 14848 110046252
Respiratory acidosis 20.98 10.60 21 528178 13805 110047295
Product preparation error 20.95 10.60 13 528186 10866 110050234
Suspected suicide 20.95 10.60 25 528174 15174 110045926
Joint injury 20.87 10.60 109 528090 39885 110021215
Application site rash 20.87 10.60 40 528159 2410 110058690
Respiratory syncytial virus infection 20.85 10.60 23 528176 14461 110046639
Pain in extremity 20.83 10.60 2644 525555 484474 109576626
Blood sodium decreased 20.82 10.60 103 528096 38216 110022884
Visual acuity reduced 20.80 10.60 81 528118 32092 110029008
Blood lactic acid increased 20.78 10.60 27 528172 15794 110045306
Myocardial ischaemia 20.78 10.60 62 528137 26622 110034478
Keratopathy 20.67 10.60 29 528170 1344 110059756
Hypoacusis 20.64 10.60 92 528107 35099 110026001
Cachexia 20.61 10.60 19 528180 12986 110048114
Panic attack 20.60 10.60 70 528129 28870 110032230
Blood pressure abnormal 20.58 10.60 48 528151 22376 110038724
Pneumonia viral 20.58 10.60 14 528185 11143 110049957
Jaw clicking 20.52 10.60 10 528189 94 110061006
Feeling jittery 20.52 10.60 24 528175 14698 110046402
Iris hypopigmentation 20.49 10.60 9 528190 65 110061035
Swollen tongue 20.36 10.60 187 528012 60175 110000925
Hypoaesthesia oral 20.36 10.60 31 528168 16971 110044129
Lactic acidosis 20.34 10.60 316 527883 92495 109968605
Blood glucose abnormal 20.32 10.60 19 528180 12897 110048203
Uterine perforation 20.27 10.60 4 528195 6836 110054264
Nasal oedema 20.27 10.60 4 528195 6835 110054265
Body temperature decreased 20.22 10.60 99 528100 36836 110024264
Rhinitis allergic 20.21 10.60 34 528165 17888 110043212
Corneal thinning 20.17 10.60 14 528185 267 110060833
Sinus node dysfunction 20.09 10.60 9 528190 9038 110052062
Acidosis 20.07 10.60 49 528150 22482 110038618
Muscle rigidity 20.06 10.60 54 528145 23977 110037123
Injection site urticaria 20.03 10.60 32 528167 17183 110043917
Parosmia 20.02 10.60 20 528179 13160 110047940
Mood swings 20.01 10.60 50 528149 22762 110038338
Congestive cardiomyopathy 20.01 10.60 23 528176 14196 110046904
Insurance issue 20.00 10.60 13 528186 10599 110050501
Bradyphrenia 19.97 10.60 16 528183 11712 110049388
Overlap syndrome 19.92 10.60 91 528108 8968 110052132
Pemphigoid 19.90 10.60 40 528159 19667 110041433
Drug effective for unapproved indication 19.85 10.60 23 528176 14144 110046956
Skin haemorrhage 19.83 10.60 57 528142 24770 110036330
Appetite disorder 19.77 10.60 11 528188 9758 110051342
Pain in jaw 19.76 10.60 153 528046 51024 110010076
Immune-mediated hepatitis 19.73 10.60 4 528195 6707 110054393
Micturition urgency 19.69 10.60 39 528160 19281 110041819
Device breakage 19.68 10.60 22 528177 13747 110047353
Cholecystitis acute 19.65 10.60 28 528171 15754 110045346
Angina unstable 19.64 10.60 30 528169 16402 110044698
Venous thrombosis 19.62 10.60 8 528191 8497 110052603
Antidepressant drug level above therapeutic 19.56 10.60 21 528178 736 110060364
Amniotic cavity disorder 19.45 10.60 8 528191 48 110061052
Vaccination site reaction 19.38 10.60 13 528186 234 110060866
Gastrointestinal infection 19.34 10.60 23 528176 13982 110047118
Fungaemia 19.26 10.60 3 528196 6083 110055017
Cytomegalovirus colitis 19.18 10.60 5 528194 7056 110054044
Nightmare 19.12 10.60 276 527923 38587 110022513
Plasma cell myeloma recurrent 19.10 10.60 5 528194 7037 110054063
Pneumothorax 19.08 10.60 95 528104 35190 110025910
Red blood cell sedimentation rate abnormal 19.04 10.60 57 528142 24452 110036648
Mitral valve incompetence 19.03 10.60 88 528111 33241 110027859
Metastases to bone 19.02 10.60 81 528118 31291 110029809
Poisoning 19.00 10.60 73 528126 29032 110032068
Asphyxia 18.94 10.60 24 528175 14191 110046909
Asthma 18.91 10.60 1414 526785 248877 109812223
Wound infection pseudomonas 18.88 10.60 38 528161 2373 110058727
Complications of transplanted kidney 18.87 10.60 6 528193 7436 110053664
Colorectal cancer 18.82 10.60 10 528189 9104 110051996
Jejunal ulcer perforation 18.71 10.60 10 528189 116 110060984
Hepatitis 18.71 10.60 563 527636 89491 109971609
Miosis 18.66 10.60 49 528150 21934 110039166
Death neonatal 18.61 10.60 31 528168 1672 110059428
Pre-eclampsia 18.60 10.60 9 528190 8641 110052459
Anhedonia 18.60 10.60 28 528171 15400 110045700
Femur fracture 18.58 10.60 130 528069 44339 110016761
Tooth infection 18.49 10.60 50 528149 22166 110038934
Respiratory tract infection viral 18.37 10.60 3 528196 5875 110055225
Mycobacterium avium complex infection 18.36 10.60 3 528196 5874 110055226
Gallbladder adenocarcinoma 18.34 10.60 10 528189 121 110060979
Drug level above therapeutic 18.28 10.60 17 528182 11571 110049529
Nystagmus 18.25 10.60 17 528182 11560 110049540
Genital haemorrhage 18.12 10.60 6 528193 7246 110053854
Epidermal necrosis 18.11 10.60 43 528156 3007 110058093
Ulcerative keratitis 18.09 10.60 57 528142 4709 110056391
Headache 18.04 10.60 3832 524367 878545 109182555
Bacterial sepsis 18.03 10.60 14 528185 10412 110050688
Dermatitis atopic 18.03 10.60 62 528137 25479 110035621
Vitamin D decreased 18.03 10.60 19 528180 12196 110048904
Brain abscess 18.02 10.60 5 528194 6769 110054331
Serum ferritin increased 17.97 10.60 18 528181 11829 110049271
Anal fistula 17.94 10.60 9 528190 8464 110052636
Cerebral haematoma 17.88 10.60 12 528187 9620 110051480
Abscess 17.86 10.60 69 528130 27400 110033700
Anal incontinence 17.86 10.60 50 528149 21914 110039186
Asthenia 17.86 10.60 2955 525244 686044 109375056
Extra dose administered 17.85 10.60 19 528180 12140 110048960
Nervousness 17.83 10.60 103 528096 36748 110024352
Food allergy 17.71 10.60 159 528040 19789 110041311
Product substitution issue 17.66 10.60 54 528145 23007 110038093
Abnormal dreams 17.63 10.60 21 528178 12759 110048341
Tubulointerstitial nephritis and uveitis syndrome 17.63 10.60 15 528184 391 110060709
Rash pruritic 17.62 10.60 346 527853 97723 109963377
Total lung capacity decreased 17.58 10.60 6 528193 7108 110053992
Arteriosclerosis 17.57 10.60 60 528139 24707 110036393
Pain of skin 17.49 10.60 44 528155 19985 110041115
Polyneuropathy 17.42 10.60 86 528113 31926 110029174
Arteriovenous fistula occlusion 17.40 10.60 17 528182 532 110060568
Urine porphobilinogen increased 17.40 10.60 4 528195 0 110061100
Aplasia cutis congenita 17.40 10.60 4 528195 0 110061100
Transplant failure 17.33 10.60 3 528196 5632 110055468
Hallucinations, mixed 17.29 10.60 10 528189 8683 110052417
Immune-mediated enterocolitis 17.21 10.60 14 528185 10171 110050929
Gait disturbance 17.21 10.60 1548 526651 276660 109784440
Infusion site erythema 17.21 10.60 19 528180 11940 110049160
Abdominal rebound tenderness 17.17 10.60 9 528190 100 110061000
Clostridium test positive 17.16 10.60 16 528183 10877 110050223
Subdural haemorrhage 17.15 10.60 5 528194 6553 110054547
Lipase increased 17.11 10.60 40 528159 18632 110042468
Acute coronary syndrome 17.07 10.60 55 528144 23057 110038043
Faeces soft 17.04 10.60 17 528182 11193 110049907
Mucosal erosion 16.97 10.60 40 528159 2784 110058316
Pneumonia cytomegaloviral 16.95 10.60 6 528193 6948 110054152
Tenderness 16.92 10.60 215 527984 29222 110031878
Inflammatory bowel disease 16.91 10.60 74 528125 7160 110053940
Movement disorder 16.91 10.60 256 527943 36148 110024952
Bone marrow oedema 16.91 10.60 34 528165 2122 110058978
Stress cardiomyopathy 16.90 10.60 31 528168 15775 110045325
Catheter site erythema 16.90 10.60 4 528195 6024 110055076
Staphylococcus test positive 16.90 10.60 7 528192 7363 110053737
Hyperthermia 16.87 10.60 49 528150 21223 110039877
Atrioventricular block second degree 16.86 10.60 9 528190 8172 110052928
Conjunctivitis allergic 16.86 10.60 6 528193 6925 110054175
Coronary artery occlusion 16.81 10.60 31 528168 15741 110045359
Intraventricular haemorrhage 16.79 10.60 3 528196 5504 110055596
Papulopustular rosacea 16.75 10.60 7 528192 44 110061056
Adrenal insufficiency 16.71 10.60 126 528073 42264 110018836
Catheter site pain 16.70 10.60 5 528194 6441 110054659
Gangrene 16.64 10.60 33 528166 16308 110044792
Intestinal congestion 16.64 10.60 5 528194 9 110061091
Metastases to stomach 16.58 10.60 13 528186 301 110060799
Metabolic encephalopathy 16.55 10.60 17 528182 11043 110050057
Aminoaciduria 16.55 10.60 14 528185 362 110060738
Nephrotic syndrome 16.52 10.60 118 528081 13713 110047387
Hepatitis B 16.51 10.60 13 528186 9599 110051501
Joint destruction 16.51 10.60 99 528100 10844 110050256
Aplastic anaemia 16.50 10.60 60 528139 24248 110036852
Ileus 16.46 10.60 83 528116 30646 110030454
Substance-induced psychotic disorder 16.44 10.60 3 528196 5421 110055679
Coronary arterial stent insertion 16.43 10.60 4 528195 5911 110055189
Blood chloride increased 16.40 10.60 5 528194 6367 110054733
Mood altered 16.40 10.60 50 528149 21325 110039775
Product administered to patient of inappropriate age 16.33 10.60 9 528190 8027 110053073
Catheter site haemorrhage 16.29 10.60 4 528195 5876 110055224
Escherichia sepsis 16.29 10.60 15 528184 10257 110050843
Crying 16.27 10.60 65 528134 25563 110035537
Fibrosis 16.24 10.60 76 528123 7566 110053534
Social avoidant behaviour 16.21 10.60 3 528196 5366 110055734
Apnoea 16.20 10.60 25 528174 13614 110047486
Urinary tract disorder 16.14 10.60 4 528195 5840 110055260
Ovarian cyst 16.11 10.60 26 528173 13904 110047196
Platelet count abnormal 16.05 10.60 5 528194 6277 110054823
Nerve stimulation test abnormal 15.98 10.60 5 528194 11 110061089
Sebaceous gland infection 15.98 10.60 10 528189 159 110060941
Application site ulcer 15.95 10.60 9 528190 117 110060983
Tender joint count 15.90 10.60 26 528173 1381 110059719
Rheumatoid lung 15.90 10.60 51 528148 4253 110056847
Leukaemia 15.90 10.60 8 528191 7510 110053590
Thyroid disorder 15.84 10.60 36 528163 16933 110044167
Product dispensing error 15.81 10.60 34 528165 16311 110044789
Hepatomegaly 15.79 10.60 51 528148 21363 110039737
Obstruction 15.77 10.60 4 528195 5748 110055352
Pneumonia klebsiella 15.69 10.60 6 528193 6626 110054474
Adenocarcinoma of colon 15.59 10.60 5 528194 6163 110054937
Specific gravity urine abnormal 15.57 10.60 8 528191 85 110061015
Renal function test abnormal 15.49 10.60 12 528187 8934 110052166
Brain death 15.47 10.60 6 528193 6567 110054533
Psychomotor retardation 15.44 10.60 9 528190 7783 110053317
Malignant mesenteric neoplasm 15.44 10.60 7 528192 55 110061045
Secondary amyloidosis 15.43 10.60 13 528186 334 110060766
Injection site induration 15.39 10.60 19 528180 11364 110049736
Allodynia 15.33 10.60 32 528167 2051 110059049
Gingivitis 15.33 10.60 16 528183 10315 110050785
Carotid artery stenosis 15.32 10.60 13 528186 9250 110051850
Neutrophilia 15.32 10.60 16 528183 10313 110050787
Jaundice cholestatic 15.31 10.60 29 528170 14579 110046521
Bone disorder 15.26 10.60 51 528148 21141 110039959
Back disorder 15.25 10.60 160 528039 20762 110040338
Post procedural haemorrhage 15.23 10.60 32 528167 15480 110045620
Amenorrhoea 15.21 10.60 13 528186 9218 110051882
Hepatic lesion 15.21 10.60 11 528188 8482 110052618
Skin tightness 15.20 10.60 4 528195 5609 110055491
Anal abscess 15.14 10.60 20 528179 11618 110049482
Hypoalbuminaemia 15.10 10.60 79 528120 28895 110032205
Erythema induratum 15.02 10.60 11 528188 229 110060871
Splenomegaly 15.01 10.60 63 528136 24435 110036665
Facial paralysis 15 10.60 62 528137 24152 110036948
Angiocardiogram 14.97 10.60 12 528187 287 110060813
Oculomucocutaneous syndrome 14.96 10.60 13 528186 349 110060751
Polyneuropathy in malignant disease 14.93 10.60 15 528184 486 110060614
Pelvic fracture 14.92 10.60 28 528171 14126 110046974
Cardiac operation 14.91 10.60 5 528194 5990 110055110
Granuloma 14.88 10.60 14 528185 9476 110051624
Abortion induced 14.87 10.60 10 528189 8009 110053091
Porphyria 14.86 10.60 11 528188 233 110060867
Nail operation 14.85 10.60 28 528171 1666 110059434
Oesophageal candidiasis 14.83 10.60 20 528179 11514 110049586
Electrocardiogram T wave peaked 14.81 10.60 23 528176 1169 110059931
Injection site extravasation 14.80 10.60 16 528183 10153 110050947
Metabolic disorder 14.79 10.60 17 528182 10493 110050607
Lymphoproliferative disorder 14.79 10.60 8 528191 7210 110053890
Surgery 14.76 10.60 126 528073 41157 110019943
Upper gastrointestinal haemorrhage 14.74 10.60 328 527871 49768 110011332
Bronchiolitis 14.71 10.60 4 528195 5489 110055611
Paralysis 14.64 10.60 33 528166 15567 110045533
Bradykinesia 14.60 10.60 18 528181 10770 110050330
Mental disorder 14.50 10.60 117 528082 38674 110022426
Product administration error 14.49 10.60 111 528088 37106 110023994
Platelet dysfunction 14.48 10.60 15 528184 504 110060596
Diastolic dysfunction 14.48 10.60 23 528176 12381 110048719
Hyperammonaemic encephalopathy 14.47 10.60 4 528195 5430 110055670
Injection site reaction 14.46 10.60 541 527658 88529 109972571
Colon cancer 14.46 10.60 36 528163 16407 110044693
Portal hypertension 14.44 10.60 12 528187 8625 110052475
Ventricular dysfunction 14.43 10.60 9 528190 7502 110053598
Dermatitis acneiform 14.39 10.60 24 528175 12671 110048429
Orbital oedema 14.39 10.60 15 528184 508 110060592
Persecutory delusion 14.38 10.60 6 528193 6285 110054815
Haematemesis 14.36 10.60 377 527822 58731 110002369
Blood immunoglobulin G decreased 14.34 10.60 4 528195 5396 110055704
Bone lesion 14.31 10.60 8 528191 7079 110054021
Dialysis 14.28 10.60 47 528152 19572 110041528
Capillary leak syndrome 14.27 10.60 3 528196 4905 110056195
Blue toe syndrome 14.23 10.60 17 528182 671 110060429
Eye infection 14.21 10.60 30 528169 14488 110046612
Cardiac massage 14.20 10.60 5 528194 18 110061082
Bundle branch block right 14.15 10.60 23 528176 12268 110048832
Choking 14.15 10.60 32 528167 15078 110046022
Gastric mucosal lesion 14.14 10.60 23 528176 1216 110059884
Neonatal respiratory distress syndrome 14.06 10.60 13 528186 379 110060721
Intentional product misuse 14.06 10.60 506 527693 132398 109928702
Muscle tightness 14.04 10.60 31 528168 14731 110046369
Bundle branch block left 14.03 10.60 25 528174 12863 110048237
Extravasation 14.01 10.60 3 528196 4842 110056258
Acute lymphocytic leukaemia 14.01 10.60 5 528194 5760 110055340
Blood potassium increased 13.99 10.60 97 528102 33152 110027948
Immune system disorder 13.98 10.60 27 528172 13474 110047626
Seroma 13.95 10.60 41 528158 3260 110057840
Human herpesvirus 6 infection 13.92 10.60 7 528192 6574 110054526
Conjunctival hyperaemia 13.90 10.60 60 528139 5771 110055329
Parainfluenzae virus infection 13.90 10.60 8 528191 6966 110054134
Organ failure 13.90 10.60 3 528196 4814 110056286
Hepatocellular carcinoma 13.89 10.60 16 528183 9864 110051236
Application site oedema 13.82 10.60 7 528192 72 110061028
Polycystic ovaries 13.81 10.60 3 528196 4793 110056307
Fibrin D dimer increased 13.77 10.60 16 528183 9829 110051271
N-terminal prohormone brain natriuretic peptide increased 13.73 10.60 6 528193 6115 110054985
Emotional disorder 13.73 10.60 36 528163 16124 110044976
Skin mass 13.68 10.60 16 528183 9800 110051300
Respiration abnormal 13.66 10.60 16 528183 9793 110051307
Neoplasm recurrence 13.66 10.60 4 528195 5228 110055872
Generalised bullous fixed drug eruption 13.65 10.60 18 528181 786 110060314
Endocarditis 13.62 10.60 27 528172 13344 110047756
Therapeutic response shortened 13.62 10.60 84 528115 29499 110031601
Cerebral ischaemia 13.61 10.60 23 528176 12081 110049019
Iritis 13.60 10.60 51 528148 4601 110056499
Acute pulmonary oedema 13.59 10.60 39 528160 16957 110044143
Cerebral atrophy 13.56 10.60 14 528185 9071 110052029
Gastric perforation 13.55 10.60 53 528146 4876 110056224
Anger 13.51 10.60 46 528153 18961 110042139
Suicide attempt 13.50 10.60 383 527816 103011 109958089
Fungal skin infection 13.50 10.60 9 528190 7240 110053860
Gingival bleeding 13.44 10.60 49 528150 19790 110041310
Eye movement disorder 13.41 10.60 16 528183 9712 110051388
Hydronephrosis 13.38 10.60 52 528147 20613 110040487
Spinal fracture 13.38 10.60 59 528140 22574 110038526
Pharyngitis streptococcal 13.36 10.60 27 528172 13250 110047850
Muscle tone disorder 13.34 10.60 10 528189 216 110060884
Drug screen positive 13.29 10.60 7 528192 6403 110054697
Punctate keratitis 13.27 10.60 22 528177 1182 110059918
Blood urine present 13.27 10.60 65 528134 24180 110036920
Sciatic nerve palsy 13.26 10.60 7 528192 79 110061021
Personality change 13.23 10.60 20 528179 10982 110050118
Potentiating drug interaction 13.21 10.60 22 528177 11621 110049479
Biliary obstruction 13.20 10.60 5 528194 5553 110055547
Injection site nodule 13.19 10.60 3 528196 4643 110056457
Libido increased 13.18 10.60 34 528165 2505 110058595
Product used for unknown indication 13.12 10.60 29 528170 1934 110059166
Drooling 13.11 10.60 9 528190 7130 110053970
Mycobacterium tuberculosis complex test positive 13.10 10.60 40 528159 3248 110057852
Electrophoresis protein 13.05 10.60 3 528196 0 110061100
Anterior chamber cell 13.04 10.60 22 528177 1199 110059901
Total cholesterol/HDL ratio 13.04 10.60 4 528195 8 110061092
Blood triglycerides 13.04 10.60 4 528195 8 110061092
High density lipoprotein 13.04 10.60 4 528195 8 110061092
Injection site hyperaesthesia 13.04 10.60 7 528192 82 110061018
Fear of injection 13.00 10.60 14 528185 8897 110052203
Blood pressure systolic decreased 12.97 10.60 28 528171 13413 110047687
Hepatitis acute 12.95 10.60 46 528153 18720 110042380
Application site reaction 12.92 10.60 18 528181 829 110060271
Aortic aneurysm 12.91 10.60 17 528182 9887 110051213
Application site injury 12.91 10.60 5 528194 25 110061075
Cerebellar syndrome 12.89 10.60 7 528192 6295 110054805
Prostatic pain 12.89 10.60 11 528188 288 110060812
Bronchial secretion retention 12.83 10.60 4 528195 5020 110056080
Product prescribing issue 12.83 10.60 26 528173 12746 110048354
Embolism venous 12.83 10.60 4 528195 5019 110056081
Infusion site swelling 12.83 10.60 17 528182 9860 110051240
Urinary retention 12.77 10.60 245 527954 69438 109991662
Creutzfeldt-Jakob disease 12.77 10.60 10 528189 231 110060869
Papilloedema 12.75 10.60 10 528189 7399 110053701
Hepatic cancer 12.73 10.60 21 528178 11135 110049965
Haemothorax 12.73 10.60 9 528190 7022 110054078
Gastrointestinal toxicity 12.71 10.60 21 528178 11127 110049973
Pulmonary congestion 12.71 10.60 91 528108 30875 110030225
Cholecystitis 12.70 10.60 72 528127 25810 110035290
Breast cancer stage I 12.68 10.60 10 528189 7377 110053723
Tongue oedema 12.65 10.60 75 528124 8181 110052919
Listless 12.65 10.60 3 528196 4512 110056588
Osteosclerosis 12.65 10.60 3 528196 4512 110056588
Lung consolidation 12.64 10.60 19 528180 10457 110050643
Burns second degree 12.61 10.60 11 528188 7722 110053378
Eye pain 12.59 10.60 166 528033 49933 110011167
Drug specific antibody present 12.58 10.60 13 528186 8421 110052679
Bloody discharge 12.57 10.60 35 528164 2698 110058402
Eating disorder 12.51 10.60 91 528108 30767 110030333
Asthmatic crisis 12.51 10.60 30 528169 2112 110058988
Left ventricular failure 12.48 10.60 22 528177 11367 110049733
Polydipsia 12.46 10.60 11 528188 7677 110053423
Hepatitis E 12.42 10.60 3 528196 4456 110056644
Ageusia 12.36 10.60 50 528149 19595 110041505
Meralgia paraesthetica 12.36 10.60 15 528184 602 110060498
Orthopnoea 12.34 10.60 21 528178 11000 110050100
Device related sepsis 12.32 10.60 11 528188 7636 110053464
Injection site discomfort 12.30 10.60 9 528190 6898 110054202
Porphyrins urine increased 12.30 10.60 5 528194 29 110061071
Pruritus genital 12.28 10.60 8 528191 6514 110054586
Factor VIII deficiency 12.22 10.60 8 528191 138 110060962
Facial paresis 12.20 10.60 7 528192 6106 110054994
Muscle swelling 12.19 10.60 20 528179 1065 110060035
Pneumocystis jirovecii infection 12.18 10.60 3 528196 4397 110056703
Pneumonia staphylococcal 12.12 10.60 7 528192 6084 110055016
Ileal perforation 12.10 10.60 23 528176 1377 110059723
Left atrial volume increased 12.08 10.60 7 528192 96 110061004
Terminal state 12.03 10.60 6 528193 5661 110055439
Withdrawal syndrome 12.03 10.60 94 528105 31286 110029814
Multiple fractures 12.01 10.60 15 528184 8925 110052175
Ammonia increased 11.99 10.60 13 528186 8237 110052863
Hypotonia 11.96 10.60 37 528162 15708 110045392
Glaucoma 11.96 10.60 61 528138 22456 110038644
Atrial thrombosis 11.96 10.60 3 528196 4343 110056757
Acquired porphyria 11.95 10.60 16 528183 709 110060391
Gingival pain 11.94 10.60 37 528162 15699 110045401
Limb discomfort 11.93 10.60 131 528068 40723 110020377
Meteoropathy 11.91 10.60 4 528195 12 110061088
Seasonal allergy 11.91 10.60 51 528148 19671 110041429
Sinus headache 11.91 10.60 7 528192 6025 110055075
Hypochromic anaemia 11.89 10.60 38 528161 3163 110057937
Menstrual disorder 11.88 10.60 4 528195 4780 110056320
Illness 11.87 10.60 300 527899 81871 109979229
Hypermobility syndrome 11.85 10.60 14 528185 546 110060554
Hepatic steatosis 11.84 10.60 163 528036 48668 110012432
Psychiatric symptom 11.82 10.60 16 528183 9197 110051903
Injection site mass 11.80 10.60 69 528130 24544 110036556
Blood immunoglobulin E increased 11.78 10.60 11 528188 7471 110053629
Long QT syndrome 11.76 10.60 10 528189 7108 110053992
Medical device site abscess 11.75 10.60 9 528190 201 110060899
Circulatory collapse 11.72 10.60 140 528059 42853 110018247
Hypoxic-ischaemic encephalopathy 11.72 10.60 15 528184 8832 110052268
Eczema herpeticum 11.72 10.60 13 528186 473 110060627
Glucose tolerance impaired 11.72 10.60 18 528181 9819 110051281
Post-traumatic neck syndrome 11.71 10.60 33 528166 2562 110058538
Retinal haemorrhage 11.69 10.60 17 528182 9484 110051616
Pyoderma streptococcal 11.67 10.60 4 528195 13 110061087
Peptic ulcer perforation 11.67 10.60 17 528182 816 110060284
Hepatic perfusion disorder 11.66 10.60 6 528193 64 110061036
Necrotising fasciitis 11.66 10.60 69 528130 7522 110053578
Impaired work ability 11.65 10.60 76 528123 26343 110034757
Mesenteric neoplasm 11.65 10.60 7 528192 103 110060997
Asthma-chronic obstructive pulmonary disease overlap syndrome 11.65 10.60 8 528191 6336 110054764
Stillbirth 11.62 10.60 3 528196 4261 110056839
Eye injury 11.60 10.60 70 528129 7685 110053415
Vitreous floaters 11.58 10.60 16 528183 9118 110051982
Pancreatitis 11.58 10.60 349 527850 93184 109967916
Neutrophil count abnormal 11.56 10.60 5 528194 5127 110055973
Blood thyroid stimulating hormone increased 11.56 10.60 26 528173 12275 110048825
Gastric polyps 11.50 10.60 6 528193 5517 110055583
Arteriospasm coronary 11.48 10.60 16 528183 9084 110052016
Blood albumin decreased 11.47 10.60 81 528118 27571 110033529
Liver abscess 11.46 10.60 12 528187 7727 110053373
Incorrect drug administration rate 11.44 10.60 6 528193 5502 110055598
Infusion site extravasation 11.42 10.60 24 528175 11610 110049490
Thirst 11.42 10.60 59 528140 21648 110039452
Pyloric stenosis 11.41 10.60 14 528185 568 110060532
Hepatic fibrosis 11.40 10.60 13 528186 8053 110053047
Lung cancer metastatic 11.35 10.60 3 528196 4195 110056905
Dizziness postural 11.33 10.60 34 528165 14575 110046525
Duodenal perforation 11.32 10.60 34 528165 2736 110058364
Type 1 diabetes mellitus 11.32 10.60 16 528183 9031 110052069
Blood magnesium decreased 11.30 10.60 53 528146 19943 110041157
Depression 11.28 10.60 1704 526495 315631 109745469
Arterial haemorrhage 11.27 10.60 42 528157 3777 110057323
Complication of device removal 11.24 10.60 4 528195 4616 110056484
Post-traumatic stress disorder 11.23 10.60 9 528190 6587 110054513
Trismus 11.23 10.60 9 528190 6587 110054513
Eschar 11.19 10.60 23 528176 1458 110059642
Klebsiella sepsis 11.17 10.60 3 528196 4150 110056950
Nephropathy toxic 11.15 10.60 81 528118 27397 110033703
Diabetes insipidus 11.14 10.60 9 528190 6561 110054539
Dermo-hypodermitis 11.12 10.60 23 528176 1465 110059635
Basal ganglion degeneration 11.10 10.60 12 528187 424 110060676
Deafness neurosensory 11.08 10.60 18 528181 9601 110051499
Menstruation irregular 11.06 10.60 7 528192 5790 110055310
Arthritis 11.06 10.60 937 527262 166649 109894451
Electroencephalogram abnormal 11.05 10.60 8 528191 6165 110054935
Reflux gastritis 11.03 10.60 23 528176 1473 110059627
Vaginal ulceration 11.01 10.60 10 528189 285 110060815
Medical device site cellulitis 10.99 10.60 9 528190 222 110060878
Leucine aminopeptidase increased 10.98 10.60 3 528196 3 110061097
Hypercapnia 10.97 10.60 23 528176 11136 110049964
Gastritis 10.96 10.60 335 527864 53364 110007736
Pyelonephritis 10.96 10.60 73 528126 25177 110035923
Omental necrosis 10.95 10.60 5 528194 40 110061060
Cardiac flutter 10.92 10.60 7 528192 5750 110055350
Haematoma muscle 10.91 10.60 3 528196 4087 110057013
Retroperitoneal haematoma 10.90 10.60 8 528191 6123 110054977
Intentional dose omission 10.89 10.60 54 528145 20026 110041074
Muscle twitching 10.86 10.60 91 528108 29844 110031256
Lipodystrophy acquired 10.86 10.60 4 528195 4520 110056580
Dermatitis 10.85 10.60 83 528116 27754 110033346
Naevus haemorrhage 10.83 10.60 7 528192 118 110060982
Testicular mass 10.83 10.60 7 528192 118 110060982
Sciatic nerve injury 10.78 10.60 16 528183 781 110060319
Body temperature increased 10.77 10.60 190 528009 54523 110006577
Intestinal atony 10.73 10.60 9 528190 230 110060870
Retroperitoneal haemorrhage 10.67 10.60 8 528191 6057 110055043
Large intestine perforation 10.67 10.60 124 528075 16505 110044595
Cardiac valve disease 10.64 10.60 9 528190 6412 110054688
Pancreatitis chronic 10.63 10.60 4 528195 4461 110056639
Acute hepatic failure 10.63 10.60 117 528082 36351 110024749
Vaginal haemorrhage 10.62 10.60 73 528126 25001 110036099

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D11AX18 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
ATC M01AB05 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
ATC M01AB55 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
ATC M02AA15 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
ATC S01BC03 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Antiinflammatory agents, non-steroids
ATC S01CC01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Antiinflammatory agents, non-steroids and antiinfectives in combination
FDA CS M0001335 Anti-Inflammatory Agents, Non-Steroidal
FDA MoA N0000000160 Cyclooxygenase Inhibitors
FDA PE N0000008836 Decreased Prostaglandin Production
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D016861 Cyclooxygenase Inhibitors
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35845 gout suppressant
CHEBI has role CHEBI:75835 anti-anaemic agent
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35481 non-narcotic analgesic
CHEBI has role CHEBI:35493 antipyretic
CHEBI has role CHEBI:35544 EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:88188 drug allergen
CHEBI has role CHEBI:176497 geroprotector

Related Drugs by ATC class:

D11AX Other dermatologicals 20 drugs
aminobenzoic acidbrimonidinecaffeinecalcium gluconatedeoxycholic acideflornithinefinasteridegamolenic acidhydrogen peroxidehydroquinoneivermectinlithium succinate show all 20 →
M01AB Acetic acid derivatives and related substances 16 drugs
aceclofenacacemetacinalclofenacbufexamacbumadizonedifenpiramideetodolacfentiazacindomethacinketorolaclonazolacoxametacin show all 16 →
M02AA Antiinflammatory preparations, non-steroids for topical use 28 drugs
aceclofenacbendazacbenzydaminebufexamacclofezonedexketoprofenesflurbiprofenetofenamatefelbinacfentiazacfeprazoneflurbiprofen show all 28 →
S01BC Antiinflammatory agents, non-steroids 10 drugs
bendazacbromfenacflurbiprofenindomethacinketorolacnepafenacoxyphenbutazonepiroxicampranoprofensalicylic acid
S01CC Antiinflammatory agents, non-steroids and antiinfectives in combination 1 drug
indomethacin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Pain indication 22253000
Tenosynovitis indication 67801009 DOID:970
Rheumatoid arthritis indication 69896004 DOID:7148
Actinic keratosis indication 201101007 DOID:8866
Dysmenorrhea indication 266599000
Lumbago indication 279039007
Osteoarthritis indication 396275006
Adhesive capsulitis of shoulder indication 399114005 DOID:14188
Post-Op Photophobia indication
Neckshoulderarm syndrome indication
Postoperative Ocular Pain indication
Rheumatoid Arthritis in Patient at High Ulcer Risk indication
Analgesia in various types of cancer indication
Sprains and Strains indication
Osteoarthritis in Patients at High Ulcer Risk indication
Osteoarthrosis of the Knee indication
Post-Op Ocular Inflammation indication
Renal colic off-label use 7093002
Tendinitis off-label use 34840004 DOID:971
Bursitis off-label use 84017003 DOID:2965
Cystoid macular edema off-label use 193387007 DOID:4447
Prevention of Ocular Surgery-Induced Miosis off-label use
Keratitis contraindication 5888003 DOID:4677
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Asthenia contraindication 13791008
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Myocardial infarction contraindication 22298006 DOID:5844
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Skin ulcer contraindication 46742003
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Corneal erosion contraindication 50792001
Duodenal ulcer disease contraindication 51868009 DOID:1724
Gastrointestinal perforation contraindication 51875005
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Gastrointestinal hemorrhage contraindication 74474003
Perforation of cornea contraindication 74895004
Corneal ulcer contraindication 91514001 DOID:8463
Corneal degeneration contraindication 111521006 DOID:1237
Open wound contraindication 125643001
Liver function tests abnormal contraindication 166603001
Asthma contraindication 195967001 DOID:2841
Deliveries by cesarean contraindication 200144004
Cerebrovascular accident contraindication 230690007
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Drug-induced hepatitis contraindication 235876009
Edema contraindication 267038008
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thromboembolic disorder contraindication 371039008
Cardiovascular event risk contraindication 395112001
Smokes tobacco daily contraindication 449868002
Uterine Rupture in Pregnancy contraindication
Bloody Vomit contraindication
Corneal Infiltrates contraindication
Gynecological Surgery contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Horses Pain and inflammation associated with osteoarthritis Indication

🐶 Veterinary products

ProductApplicantIngredients
Surpass Topical Anti-Inflammatory Cream Boehringer lngelheim Animal Health USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.22 acidic
pKa2 0.55 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
50MG CAMBIA COSETTE N022165 June 17, 2009 RX FOR SOLUTION ORAL 7759394 June 16, 2026 ACUTE TREATMENT OF MIGRAINE ATTACKS WITH OR WITHOUT AURA IN ADULTS
50MG CAMBIA COSETTE N022165 June 17, 2009 RX FOR SOLUTION ORAL 8097651 June 16, 2026 ACUTE TREATMENT OF MIGRAINE ATTACKS WITH OR WITHOUT AURA IN ADULTS
50MG CAMBIA COSETTE N022165 June 17, 2009 RX FOR SOLUTION ORAL 8927604 June 16, 2026 ACUTE TREATMENT OF MIGRAINE ATTACKS WITH OR WITHOUT AURA IN ADULTS
37.5MG/ML (37.5MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** DYLOJECT JAVELIN PHARMS INC N022396 Dec. 23, 2014 DISCN SOLUTION INTRAVENOUS 8946292 March 22, 2027 MANAGEMENT OF PAIN
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 8563613 Oct. 17, 2027 USE OF TOPICAL DICLOFENAC FOR TREATING PAIN
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 8871809 Oct. 17, 2027 USE OF TOPICAL DICLOFENAC SODIUM FOR TREATING PAIN
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 9066913 Oct. 17, 2027 USE OF TOPICAL DICLOFENAC FOR TREATING PAIN
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 9101591 Oct. 17, 2027 USE OF TOPICAL DICLOFENAC FOR TREATING PAIN
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 9132110 Oct. 17, 2027 USE OF TOPICAL DICLOFENAC FOR TREATING PAIN
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 9168305 Oct. 17, 2027 USE OF TOPICAL DICLOFENAC FOR TREATING PAIN
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 9220784 Oct. 17, 2027 USE OF TOPICAL DICLOFENAC FOR TREATING PAIN
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 9339551 Oct. 17, 2027 USE OF TOPICAL DICLOFENAC FOR TREATING PAIN
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 9339552 Oct. 17, 2027 USE OF TOPICAL DICLOFENAC FOR TREATING PAIN
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 9539335 Oct. 17, 2027 USE OF TOPICAL DICLOFENAC SODIUM FOR TREATING PAIN
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 8252838 April 21, 2028 USE OF TOPICAL DICLOFENAC ON A JOINT FOR TREATING OSTEOARTHRITIS
25MG ZIPSOR COSETTE N022202 June 16, 2009 RX CAPSULE ORAL 7662858 Feb. 24, 2029 NONSTEROIDAL ANTI-INFLAMMATORY DRUG INDICATED FOR RELIEF OF MILD TO MODERATE ACUTE PAIN
25MG ZIPSOR COSETTE N022202 June 16, 2009 RX CAPSULE ORAL 7884095 Feb. 24, 2029 NONSTEROIDAL ANTI-INFLAMMATORY DRUG INDICATED FOR RELIEF OF MILD TO MODERATE ACUTE PAIN
25MG ZIPSOR COSETTE N022202 June 16, 2009 RX CAPSULE ORAL 7939518 Feb. 24, 2029 NONSTEROIDAL ANTI-INFLAMMATORY DRUG INDICATED FOR RELIEF OF MILD TO MODERATE ACUTE PAIN
25MG ZIPSOR COSETTE N022202 June 16, 2009 RX CAPSULE ORAL 8110606 Feb. 24, 2029 NONSTEROIDAL ANTI-INFLAMMATORY DRUG INDICATED FOR RELIEF OF MILD TO MODERATE ACUTE PAIN
25MG ZIPSOR COSETTE N022202 June 16, 2009 RX CAPSULE ORAL 8623920 Feb. 24, 2029 DICLOFENAC POTASSIUM FOR RELIEF OF MILD TO MODERATE ACUTE PAIN
25MG ZIPSOR COSETTE N022202 June 16, 2009 RX CAPSULE ORAL 9561200 Feb. 24, 2029 DICLOFENAC POTASSIUM FOR RELIEF OF MILD TO MODERATE ACUTE PAIN
1.5% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID NUVO PHARMS INC N020947 Nov. 4, 2009 DISCN SOLUTION TOPICAL 8217078 July 10, 2029 USE OF TOPICAL DICLOFENAC ON THE KNEE AND A SECOND TOPICAL MEDICATION ON THE SAME KNEE
1.5% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID NUVO PHARMS INC N020947 Nov. 4, 2009 DISCN SOLUTION TOPICAL 8618164 July 10, 2029 USE OF TOPICAL DICLOFENAC ON THE KNEE AND A SECOND TOPICAL PRESCRIPTION MEDICATION ON THE SAME KNEE
1.5% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID NUVO PHARMS INC N020947 Nov. 4, 2009 DISCN SOLUTION TOPICAL 8741956 July 10, 2029 COMBINATION USE OF TOPICAL DICLOFENAC ON THE KNEE AND ADMINISTRATION OF AN ORAL NSAID.
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 8217078 July 10, 2029 USE OF TOPICAL DICLOFENAC ON THE KNEE AND A SECOND TOPICAL PRESCRIPTION MEDICATION ON THE SAME KNEE
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 8618164 July 10, 2029 USE OF TOPICAL DICLOFENAC ON THE KNEE AND A SECOND TOPICAL PRESCRIPTION MEDICATION ON THE SAME KNEE
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 8741956 July 10, 2029 COMBINATION USE OF TOPICAL DICLOFENAC ON THE KNEE AND ADMINISTRATION OF AN ORAL NSAID.
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 9370501 July 10, 2029 USE OF TOPICAL DICLOFENAC SODIUM FOR TREATING PAIN
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 9375412 July 10, 2029 USE OF TOPICAL DICLOFENAC SODIUM FOR TREATING PAIN
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 9415029 July 10, 2029 USE OF TOPICAL DICLOFENAC SODIUM FOR TREATING PAIN
18MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** ZORVOLEX ZYLA N204592 Oct. 18, 2013 DISCN CAPSULE ORAL 8999387 April 23, 2030 TREATMENT OF PAIN
18MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** ZORVOLEX ZYLA N204592 Oct. 18, 2013 DISCN CAPSULE ORAL 9180095 April 23, 2030 TREATMENT OF PAIN
18MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** ZORVOLEX ZYLA N204592 Oct. 18, 2013 DISCN CAPSULE ORAL 9186328 April 23, 2030 TREATMENT OF PAIN
35MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** ZORVOLEX ZYLA N204592 Oct. 18, 2013 DISCN CAPSULE ORAL 8999387 April 23, 2030 TREATMENT OF PAIN
35MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** ZORVOLEX ZYLA N204592 Oct. 18, 2013 DISCN CAPSULE ORAL 9180095 April 23, 2030 TREATMENT OF PAIN
35MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** ZORVOLEX ZYLA N204592 Oct. 18, 2013 DISCN CAPSULE ORAL 9186328 April 23, 2030 TREATMENT OF PAIN
1.5% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID NUVO PHARMS INC N020947 Nov. 4, 2009 DISCN SOLUTION TOPICAL 8546450 Aug. 9, 2030 COMBINATION USE OF TOPICAL DICLOFENAC ON THE KNEE AND ADMINISTRATION OF AN ORAL NSAID.
1.5% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID NUVO PHARMS INC N020947 Nov. 4, 2009 DISCN SOLUTION TOPICAL 8546450 Aug. 9, 2030 USE OF TOPICAL DICLOFENAC ON THE KNEE AND A SECOND TOPICAL AGENT SELECTED FROM SUNSCREEN AND INSECT REPELLANT
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 8546450 Aug. 9, 2030 COMBINATION USE OF TOPICAL DICLOFENAC ON THE KNEE AND ADMINISTRATION OF AN ORAL NSAID.
2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** PENNSAID HORIZON N204623 Jan. 16, 2014 DISCN SOLUTION TOPICAL 8546450 Aug. 9, 2030 USE OF TOPICAL DICLOFENAC ON THE KNEE AND A SECOND TOPICAL AGENT SELECTED FROM SUNSCREEN AND INSECT REPELLANT
1.3% LICART IBSA INST BIO N206976 Dec. 19, 2018 RX SYSTEM TOPICAL 11344520 Feb. 20, 2035 METHOD OF TREATING ACUTE PAIN DUE TO MINOR STRAINS, SPRAINS, AND CONTUSIONS USING A DICLOFENAC PATCH CONTAINING HEPARIN FOR ONCE DAILY ADMINISTRATION WHERE HEPARIN IS NOT RELEASED
1.3% LICART IBSA INST BIO N206976 Dec. 19, 2018 RX SYSTEM TOPICAL 11351133 Feb. 20, 2035 METHOD OF TREATING ACUTE PAIN DUE TO MINOR STRAINS, SPRAINS, AND CONTUSIONS USING A DICLOFENAC PATCH CONTAINING HEPARIN FOR ONCE DAILY ADMINISTRATION WHERE HEPARIN IS NOT RELEASED

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
1.3% LICART IBSA INST BIO N206976 Dec. 19, 2018 RX SYSTEM TOPICAL March 27, 2029 NEW PATIENT POPULATION

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 7.70 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 7.52 WOMBAT-PK CHEMBL
Transthyretin Secreted Kd 6 CHEMBL
Aldo-keto reductase family 1 member C3 Enzyme IC50 5.59 CHEMBL
Peroxisome proliferator-activated receptor gamma Nuclear hormone receptor ANTAGONIST Ki 6.20 IUPHAR
Cytochrome c oxidase subunit 2 Enzyme IC50 5 CHEMBL
Interleukin-8 Cytokine IC50 8.10 CHEMBL
Transient receptor potential cation channel subfamily A member 1 Ion channel EC50 4.25 CHEMBL
Aldo-keto reductase family 1 member B10 Enzyme IC50 5.72 CHEMBL
Acid-sensing ion channel 3 Ion channel BLOCKER IC50 4 IUPHAR
C-X-C chemokine receptor type 1 GPCR IC50 7.92 CHEMBL
UDP-glucuronosyltransferase 1-1 Enzyme Ki 4.28 CHEMBL
UDP-glucuronosyltransferase 1-7 Enzyme Ki 4.72 CHEMBL
UDP-glucuronosyltransferase 1-6 Enzyme Ki 4.64 CHEMBL
UDP-glucuronosyltransferase 1-9 Enzyme Ki 4.96 CHEMBL
UDP-glucuronosyltransferase 1-10 Enzyme Ki 4.55 CHEMBL
Transient receptor potential cation channel subfamily M member 3 Ion channel BLOCKER IC50 5.20 IUPHAR
Fatty acid-binding protein, liver Cytosolic other Ki 5.49 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 7.66 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 7.17 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 7.22 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 8.52 CHEMBL

External reference:

IDSource
4019714 VUID
N0000147806 NUI
D00903 KEGG_DRUG
88170-10-9 SECONDARY_CAS_RN
78213-16-8 SECONDARY_CAS_RN
15307-79-6 SECONDARY_CAS_RN
15307-81-0 SECONDARY_CAS_RN
119623-66-4 SECONDARY_CAS_RN
203214 RXNORM
4019378 VANDF
4019714 VANDF
4020829 VANDF
4027248 VANDF
C0012091 UMLSCUI
CHEBI:47381 CHEBI
DIF PDB_CHEM_ID
CHEMBL139 ChEMBL_ID
CHEMBL1034 ChEMBL_ID
CHEMBL1200804 ChEMBL_ID
DB00586 DRUGBANK_ID
CHEMBL1201180 ChEMBL_ID
D004008 MESH_DESCRIPTOR_UI
3033 PUBCHEM_CID
2714 IUPHAR_LIGAND_ID
C000614065 MESH_SUPPLEMENTAL_RECORD_UI
C064142 MESH_SUPPLEMENTAL_RECORD_UI
3270 INN_ID
144O8QL0L1 UNII
11838 MMSL
23373 MMSL
3184 MMSL
340620 MMSL
37364 MMSL
4582 MMSL
4583 MMSL
4584 MMSL
d00848 MMSL
002391 NDDF
004409 NDDF
004410 NDDF
005170 NDDF
006237 NDDF
108515008 SNOMEDCT_US
363598004 SNOMEDCT_US
425650004 SNOMEDCT_US
426714006 SNOMEDCT_US
62039007 SNOMEDCT_US
7034005 SNOMEDCT_US
144O8QL0L1 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ARTHROTEC HUMAN PRESCRIPTION DRUG LABEL 2 0025-1411 TABLET, FILM COATED 50 mg ORAL NDA 31 sections
ARTHROTEC HUMAN PRESCRIPTION DRUG LABEL 2 0025-1421 TABLET, FILM COATED 75 mg ORAL NDA 31 sections
VoltarenArthritis Pain HUMAN OTC DRUG LABEL 1 0067-8152 GEL 10 mg TOPICAL NDA 18 sections
Diclofenac Potassium HUMAN PRESCRIPTION DRUG LABEL 1 0093-0948 TABLET, FILM COATED 50 mg ORAL ANDA 14 sections
diclofenac epolamine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3727 SYSTEM 0.01 g TOPICAL NDA authorized generic 31 sections
good sense arthritis pain HUMAN OTC DRUG LABEL 1 0113-1189 GEL 10 mg TOPICAL ANDA 17 sections
GOOD SENSE ARTHRITIS PAIN HUMAN OTC DRUG LABEL 1 0113-8175 GEL 10 mg TOPICAL ANDA 17 sections
Diclofenac Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1483 GEL 30 mg TOPICAL ANDA 29 sections
Diclofenac Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0228-2550 TABLET, DELAYED RELEASE 50 mg ORAL ANDA 26 sections
Diclofenac Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0228-2551 TABLET, DELAYED RELEASE 75 mg ORAL ANDA 26 sections
Aleve Arthritis Pain Gel HUMAN OTC DRUG LABEL 1 0280-0039 GEL 1 mg TOPICAL ANDA 17 sections
Diclofenac sodium HUMAN OTC DRUG LABEL 1 0363-1210 GEL 10 mg TOPICAL ANDA 17 sections
ARTHRITIS PAIN RELIEVING HUMAN OTC DRUG LABEL 1 0363-3003 GEL 10 mg TOPICAL ANDA 17 sections
arthritis pain relieving HUMAN OTC DRUG LABEL 1 0363-5123 GEL 10 mg TOPICAL ANDA 17 sections
Diclofenac Sodium Topical Gel 1% Human OTC Drug Label 1 0363-7065 GEL 10 mg TOPICAL ANDA 16 sections
Diclofenac Sodium Topical Gel 1% Human OTC Drug Label 1 0363-7065 GEL 10 mg TOPICAL ANDA 16 sections
Diclofenac Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0472-1783 GEL 30 mg TOPICAL ANDA 29 sections
Diclofenac potassium HUMAN PRESCRIPTION DRUG LABEL 1 0480-9435 CAPSULE, LIQUID FILLED 25 mg ORAL ANDA 23 sections
Diclofenac sodium HUMAN OTC DRUG LABEL 1 0536-1294 GEL 10 mg TOPICAL ANDA 17 sections
Diclofenac Sodium and Misoprostol HUMAN PRESCRIPTION DRUG LABEL 2 0591-0397 TABLET, DELAYED RELEASE 50 mg ORAL ANDA 28 sections
Diclofenac Sodium and Misoprostol HUMAN PRESCRIPTION DRUG LABEL 2 0591-0398 TABLET, DELAYED RELEASE 75 mg ORAL ANDA 28 sections
Diclofenac Potassium HUMAN PRESCRIPTION DRUG LABEL 1 10135-806 TABLET, FILM COATED 50 mg ORAL ANDA 26 sections
Diclofenac Sodium HUMAN PRESCRIPTION DRUG LABEL 1 10544-114 TABLET, DELAYED RELEASE 50 mg ORAL ANDA 24 sections
Diclofenac SodiumDelayed Release HUMAN PRESCRIPTION DRUG LABEL 1 10544-188 TABLET, DELAYED RELEASE 50 mg ORAL ANDA 28 sections
Diclofenac SodiumDelayed Release HUMAN PRESCRIPTION DRUG LABEL 1 10544-189 TABLET, DELAYED RELEASE 75 mg ORAL ANDA 28 sections
Diclofenac Sodium HUMAN PRESCRIPTION DRUG LABEL 1 10544-921 TABLET, DELAYED RELEASE 75 mg ORAL ANDA 24 sections
Diclofenac Sodium HUMAN PRESCRIPTION DRUG LABEL 1 10544-923 TABLET, DELAYED RELEASE 50 mg ORAL ANDA 25 sections
Diclofenac Sodium HUMAN PRESCRIPTION DRUG LABEL 1 10544-928 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL ANDA 17 sections
Diclofenac Sodium HUMAN PRESCRIPTION DRUG LABEL 1 10544-933 TABLET, DELAYED RELEASE 75 mg ORAL ANDA 21 sections
Diclofenac Sodium HUMAN PRESCRIPTION DRUG LABEL 1 10544-934 TABLET, DELAYED RELEASE 50 mg ORAL ANDA 24 sections