Stem definition | Drug id | CAS RN |
---|---|---|
anti-inflammatory agents, ibufenac derivatives | 865 | 15307-86-5 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
0.10 | g | P |
0.10 | g | R |
0.10 | g | O |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 10.85 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Hosey CM, Chan R, Benet LZ |
S (Water solubility) | 0.14 mg/mL | Hosey CM, Chan R, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Hosey CM, Chan R, Benet LZ |
BA (Bioavailability) | 54 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.22 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 28, 1988 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Embolia cutis medicamentosa | 708.95 | 9.63 | 167 | 150744 | 107 | 46535044 |
Pemphigus | 618.22 | 9.63 | 747 | 150164 | 44527 | 46490624 |
Glossodynia | 552.52 | 9.63 | 699 | 150212 | 43674 | 46491477 |
Rheumatoid arthritis | 510.42 | 9.63 | 1820 | 149091 | 238395 | 46296756 |
Systemic lupus erythematosus | 471.21 | 9.63 | 794 | 150117 | 64386 | 46470765 |
Hand deformity | 461.39 | 9.63 | 564 | 150347 | 34010 | 46501141 |
Anti-cyclic citrullinated peptide antibody positive | 444.68 | 9.63 | 419 | 150492 | 18726 | 46516425 |
Abdominal discomfort | 400.59 | 9.63 | 1235 | 149676 | 149930 | 46385221 |
Pericarditis | 382.00 | 9.63 | 428 | 150483 | 23499 | 46511652 |
Wound | 350.74 | 9.63 | 552 | 150359 | 42250 | 46492901 |
Death | 320.58 | 9.63 | 368 | 150543 | 335180 | 46199971 |
Arthropathy | 284.38 | 9.63 | 754 | 150157 | 83946 | 46451205 |
Rheumatoid factor positive | 274.87 | 9.63 | 335 | 150576 | 20126 | 46515025 |
Discomfort | 264.95 | 9.63 | 512 | 150399 | 46158 | 46488993 |
Contraindicated product administered | 257.60 | 9.63 | 701 | 150210 | 79246 | 46455905 |
Product use issue | 232.73 | 9.63 | 754 | 150157 | 93890 | 46441261 |
Duodenal ulcer perforation | 226.52 | 9.63 | 201 | 150710 | 8301 | 46526850 |
Deafness transitory | 199.52 | 9.63 | 100 | 150811 | 1532 | 46533619 |
Pain | 198.36 | 9.63 | 2382 | 148529 | 474566 | 46060585 |
Swelling | 194.64 | 9.63 | 858 | 150053 | 123653 | 46411498 |
Treatment failure | 191.59 | 9.63 | 699 | 150212 | 92388 | 46442763 |
Synovitis | 181.38 | 9.63 | 520 | 150391 | 60555 | 46474596 |
Maternal exposure during pregnancy | 179.11 | 9.63 | 731 | 150180 | 101818 | 46433333 |
Completed suicide | 173.24 | 9.63 | 131 | 150780 | 145789 | 46389362 |
Alopecia | 170.11 | 9.63 | 1000 | 149911 | 161414 | 46373737 |
Melaena | 154.29 | 9.63 | 302 | 150609 | 27470 | 46507681 |
Gastric ulcer | 148.18 | 9.63 | 259 | 150652 | 21604 | 46513547 |
Febrile neutropenia | 146.73 | 9.63 | 61 | 150850 | 94566 | 46440585 |
Joint swelling | 144.31 | 9.63 | 975 | 149936 | 165098 | 46370053 |
Neutropenia | 144.20 | 9.63 | 150 | 150761 | 143054 | 46392097 |
Helicobacter infection | 141.40 | 9.63 | 182 | 150729 | 11554 | 46523597 |
Infusion related reaction | 136.40 | 9.63 | 668 | 150243 | 100540 | 46434611 |
Pharyngitis | 134.68 | 9.63 | 220 | 150691 | 17363 | 46517788 |
Hypersensitivity | 129.06 | 9.63 | 880 | 150031 | 149441 | 46385710 |
Sleep disorder | 127.06 | 9.63 | 386 | 150525 | 46409 | 46488742 |
Gastrointestinal pain | 121.76 | 9.63 | 135 | 150776 | 7320 | 46527831 |
Gastric ulcer perforation | 119.70 | 9.63 | 63 | 150848 | 1074 | 46534077 |
Ear infection | 114.43 | 9.63 | 239 | 150672 | 22774 | 46512377 |
Musculoskeletal stiffness | 104.17 | 9.63 | 606 | 150305 | 97387 | 46437764 |
Ankylosing spondylitis | 103.21 | 9.63 | 118 | 150793 | 6619 | 46528532 |
Pneumonia | 99.19 | 9.63 | 761 | 150150 | 375559 | 46159592 |
Hip arthroplasty | 98.23 | 9.63 | 195 | 150716 | 17917 | 46517234 |
Anaphylactic shock | 94.39 | 9.63 | 205 | 150706 | 20069 | 46515082 |
Hepatic enzyme increased | 88.36 | 9.63 | 508 | 150403 | 81279 | 46453872 |
Rash | 86.59 | 9.63 | 1625 | 149286 | 354887 | 46180264 |
Cardiac failure congestive | 85.84 | 9.63 | 102 | 150809 | 91648 | 46443503 |
Shoulder arthroplasty | 85.83 | 9.63 | 75 | 150836 | 3033 | 46532118 |
Knee arthroplasty | 81.68 | 9.63 | 213 | 150698 | 23452 | 46511699 |
Toxicity to various agents | 79.42 | 9.63 | 383 | 150528 | 211383 | 46323768 |
Drug intolerance | 78.51 | 9.63 | 773 | 150138 | 146276 | 46388875 |
Duodenal ulcer | 76.29 | 9.63 | 105 | 150806 | 7113 | 46528038 |
Angioedema | 72.24 | 9.63 | 285 | 150626 | 39057 | 46496094 |
Thrombocytopenia | 70.55 | 9.63 | 194 | 150717 | 126387 | 46408764 |
International normalised ratio fluctuation | 66.84 | 9.63 | 56 | 150855 | 2137 | 46533014 |
Anaphylactic reaction | 65.47 | 9.63 | 342 | 150569 | 52770 | 46482381 |
Plasma cell myeloma | 63.74 | 9.63 | 32 | 150879 | 44446 | 46490705 |
Electrocardiogram QT prolonged | 63.56 | 9.63 | 44 | 150867 | 51281 | 46483870 |
Oligohydramnios | 63.10 | 9.63 | 83 | 150828 | 5382 | 46529769 |
Tonsillar ulcer | 63.03 | 9.63 | 26 | 150885 | 245 | 46534906 |
Seizure | 62.48 | 9.63 | 197 | 150714 | 122857 | 46412294 |
Device expulsion | 61.77 | 9.63 | 8 | 150903 | 27534 | 46507617 |
Large intestinal stenosis | 61.26 | 9.63 | 49 | 150862 | 1750 | 46533401 |
Intestinal diaphragm disease | 61.13 | 9.63 | 20 | 150891 | 89 | 46535062 |
Large intestinal ulcer | 58.57 | 9.63 | 61 | 150850 | 3078 | 46532073 |
Small intestine ulcer | 58.40 | 9.63 | 26 | 150885 | 300 | 46534851 |
Haematemesis | 58.08 | 9.63 | 215 | 150696 | 28591 | 46506560 |
Type I hypersensitivity | 57.64 | 9.63 | 53 | 150858 | 2293 | 46532858 |
Swollen joint count increased | 54.70 | 9.63 | 52 | 150859 | 2348 | 46532803 |
Dyspnoea | 54.46 | 9.63 | 1261 | 149650 | 514287 | 46020864 |
Arthralgia | 53.38 | 9.63 | 1549 | 149362 | 363054 | 46172097 |
Renal failure neonatal | 53 | 9.63 | 19 | 150892 | 117 | 46535034 |
Off label use | 52.80 | 9.63 | 887 | 150024 | 378954 | 46156197 |
Osteoarthritis | 51.88 | 9.63 | 361 | 150550 | 61664 | 46473487 |
Hospitalisation | 50.65 | 9.63 | 79 | 150832 | 63306 | 46471845 |
Ileal ulcer | 50.59 | 9.63 | 26 | 150885 | 421 | 46534730 |
Product dose omission issue | 50.50 | 9.63 | 328 | 150583 | 168192 | 46366959 |
Foot operation | 50.20 | 9.63 | 69 | 150842 | 4668 | 46530483 |
Drug hypersensitivity | 49.62 | 9.63 | 1083 | 149828 | 242742 | 46292409 |
Ductus arteriosus stenosis foetal | 48.51 | 9.63 | 17 | 150894 | 97 | 46535054 |
Hypotension | 48.09 | 9.63 | 500 | 150411 | 232089 | 46303062 |
Diarrhoea | 45.92 | 9.63 | 1419 | 149492 | 558183 | 45976968 |
Dehydration | 45.56 | 9.63 | 315 | 150596 | 159225 | 46375926 |
Porphyria acute | 45.50 | 9.63 | 23 | 150888 | 359 | 46534792 |
Gastritis erosive | 45.37 | 9.63 | 70 | 150841 | 5260 | 46529891 |
Hypokalaemia | 45.31 | 9.63 | 140 | 150771 | 87884 | 46447267 |
Injection site necrosis | 44.05 | 9.63 | 36 | 150875 | 1326 | 46533825 |
Foetal methotrexate syndrome | 43.98 | 9.63 | 14 | 150897 | 56 | 46535095 |
Rheumatic fever | 43.89 | 9.63 | 50 | 150861 | 2793 | 46532358 |
Lower respiratory tract infection viral | 43.82 | 9.63 | 25 | 150886 | 503 | 46534648 |
Cardio-respiratory arrest | 43.79 | 9.63 | 79 | 150832 | 59790 | 46475361 |
Cardiac arrest | 43.60 | 9.63 | 148 | 150763 | 90251 | 46444900 |
Ductus arteriosus premature closure | 42.05 | 9.63 | 21 | 150890 | 319 | 46534832 |
Pulmonary mass | 41.79 | 9.63 | 140 | 150771 | 17717 | 46517434 |
Duodenal ulcer haemorrhage | 41.75 | 9.63 | 45 | 150866 | 2363 | 46532788 |
Pulmonary arterial hypertension | 41.33 | 9.63 | 16 | 150895 | 25912 | 46509239 |
Tubulointerstitial nephritis | 41.07 | 9.63 | 123 | 150788 | 14665 | 46520486 |
Feeding disorder | 40.69 | 9.63 | 97 | 150814 | 10097 | 46525054 |
Atrial fibrillation | 40.16 | 9.63 | 185 | 150726 | 103405 | 46431746 |
Pancytopenia | 39.18 | 9.63 | 142 | 150769 | 84916 | 46450235 |
Endoscopy abnormal | 38.68 | 9.63 | 9 | 150902 | 5 | 46535146 |
Jejunal ulcer | 38.68 | 9.63 | 14 | 150897 | 89 | 46535062 |
Aspirin-exacerbated respiratory disease | 38.18 | 9.63 | 26 | 150885 | 722 | 46534429 |
Bloody discharge | 38.10 | 9.63 | 29 | 150882 | 962 | 46534189 |
Leukopenia | 37.86 | 9.63 | 105 | 150806 | 68238 | 46466913 |
Gastrointestinal disorder | 37.72 | 9.63 | 325 | 150586 | 59251 | 46475900 |
Cerebrovascular accident | 37.67 | 9.63 | 183 | 150728 | 100856 | 46434295 |
Psoriatic arthropathy | 37.34 | 9.63 | 223 | 150688 | 36156 | 46498995 |
Sepsis | 36.66 | 9.63 | 273 | 150638 | 135741 | 46399410 |
Infection | 35.47 | 9.63 | 618 | 150293 | 132974 | 46402177 |
No adverse event | 35.38 | 9.63 | 35 | 150876 | 34196 | 46500955 |
Gastrointestinal erosion | 35.20 | 9.63 | 23 | 150888 | 595 | 46534556 |
Deafness | 35.00 | 9.63 | 123 | 150788 | 15945 | 46519206 |
Cough | 34.82 | 9.63 | 529 | 150382 | 229720 | 46305431 |
Intestinal ulcer | 34.62 | 9.63 | 28 | 150883 | 1016 | 46534135 |
Blister | 34.55 | 9.63 | 255 | 150656 | 44376 | 46490775 |
Large intestine perforation | 34.54 | 9.63 | 76 | 150835 | 7504 | 46527647 |
Application site rash | 34.22 | 9.63 | 42 | 150869 | 2540 | 46532611 |
Spinal pain | 34.09 | 9.63 | 89 | 150822 | 9803 | 46525348 |
Blood lactate dehydrogenase increased | 34.05 | 9.63 | 144 | 150767 | 20356 | 46514795 |
White blood cell count decreased | 33.82 | 9.63 | 218 | 150693 | 112013 | 46423138 |
Rheumatoid lung | 33.46 | 9.63 | 34 | 150877 | 1666 | 46533485 |
Urinary tract infection | 32.30 | 9.63 | 509 | 150402 | 219757 | 46315394 |
Fat necrosis | 31.88 | 9.63 | 21 | 150890 | 551 | 46534600 |
Constipation | 31.72 | 9.63 | 385 | 150526 | 173712 | 46361439 |
Functional gastrointestinal disorder | 31.58 | 9.63 | 45 | 150866 | 3149 | 46532002 |
Spinal stenosis | 30.83 | 9.63 | 100 | 150811 | 12443 | 46522708 |
Neutrophil count decreased | 30.26 | 9.63 | 59 | 150852 | 43367 | 46491784 |
Hypoxia | 29.95 | 9.63 | 78 | 150833 | 51760 | 46483391 |
Hypoglycaemia | 29.73 | 9.63 | 84 | 150827 | 54265 | 46480886 |
Fibromyalgia | 29.18 | 9.63 | 210 | 150701 | 36253 | 46498898 |
Mental status changes | 28.99 | 9.63 | 49 | 150862 | 38039 | 46497112 |
Anxiety | 28.90 | 9.63 | 414 | 150497 | 181543 | 46353608 |
Gastric ulcer haemorrhage | 28.33 | 9.63 | 54 | 150857 | 4814 | 46530337 |
Fluid retention | 27.84 | 9.63 | 79 | 150832 | 50967 | 46484184 |
Corneal epithelium defect | 27.56 | 9.63 | 16 | 150895 | 333 | 46534818 |
Soft tissue infection | 27.53 | 9.63 | 33 | 150878 | 1947 | 46533204 |
Joint dislocation | 27.33 | 9.63 | 89 | 150822 | 11097 | 46524054 |
Gastrointestinal haemorrhage | 27.05 | 9.63 | 375 | 150536 | 76998 | 46458153 |
Orbital oedema | 26.85 | 9.63 | 13 | 150898 | 184 | 46534967 |
Hyperglycaemia | 26.80 | 9.63 | 45 | 150866 | 35026 | 46500125 |
Fall | 26.76 | 9.63 | 835 | 150076 | 328262 | 46206889 |
Ejection fraction | 26.53 | 9.63 | 19 | 150892 | 573 | 46534578 |
Posterior reversible encephalopathy syndrome | 26.46 | 9.63 | 8 | 150903 | 15133 | 46520018 |
Acute myeloid leukaemia | 26.40 | 9.63 | 9 | 150902 | 15769 | 46519382 |
Platelet count decreased | 26.36 | 9.63 | 202 | 150709 | 99822 | 46435329 |
Neonatal respiratory acidosis | 26.34 | 9.63 | 9 | 150902 | 47 | 46535104 |
Synostosis | 26.18 | 9.63 | 9 | 150902 | 48 | 46535103 |
Disease progression | 26.17 | 9.63 | 180 | 150731 | 91120 | 46444031 |
Periorbital oedema | 25.85 | 9.63 | 53 | 150858 | 4982 | 46530169 |
Pyrexia | 25.76 | 9.63 | 896 | 150015 | 347906 | 46187245 |
C-reactive protein abnormal | 25.33 | 9.63 | 19 | 150892 | 21251 | 46513900 |
Grip strength decreased | 25.25 | 9.63 | 73 | 150838 | 8533 | 46526618 |
Pulmonary toxicity | 24.81 | 9.63 | 50 | 150861 | 4643 | 46530508 |
Lip ulceration | 24.42 | 9.63 | 29 | 150882 | 1694 | 46533457 |
Respiratory distress | 24.35 | 9.63 | 41 | 150870 | 31875 | 46503276 |
Drug ineffective | 24.33 | 9.63 | 2523 | 148388 | 675315 | 45859836 |
Cardiac failure | 24.23 | 9.63 | 155 | 150756 | 79793 | 46455358 |
Bradycardia | 24.17 | 9.63 | 121 | 150790 | 66177 | 46468974 |
Keratopathy | 24.09 | 9.63 | 14 | 150897 | 292 | 46534859 |
Joint stiffness | 23.98 | 9.63 | 160 | 150751 | 26948 | 46508203 |
Coma | 23.94 | 9.63 | 102 | 150809 | 58247 | 46476904 |
C-reactive protein increased | 23.85 | 9.63 | 292 | 150619 | 58298 | 46476853 |
Complication associated with device | 23.84 | 9.63 | 10 | 150901 | 15431 | 46519720 |
Abdominal rebound tenderness | 23.78 | 9.63 | 7 | 150904 | 20 | 46535131 |
Gastritis | 23.60 | 9.63 | 191 | 150720 | 34187 | 46500964 |
Lymphatic fistula | 23.46 | 9.63 | 21 | 150890 | 877 | 46534274 |
Pulmonary embolism | 23.40 | 9.63 | 231 | 150680 | 108354 | 46426797 |
Pancreatic steatosis | 23.33 | 9.63 | 22 | 150889 | 983 | 46534168 |
Lymphocyte stimulation test positive | 23.26 | 9.63 | 18 | 150893 | 612 | 46534539 |
Femoral hernia incarcerated | 23.24 | 9.63 | 21 | 150890 | 888 | 46534263 |
Congenital pulmonary hypertension | 23.21 | 9.63 | 9 | 150902 | 71 | 46535080 |
Neuroleptic malignant syndrome | 23.17 | 9.63 | 4 | 150907 | 11118 | 46524033 |
Multiple sclerosis relapse | 23.12 | 9.63 | 65 | 150846 | 42060 | 46493091 |
Lyme disease | 22.93 | 9.63 | 33 | 150878 | 2330 | 46532821 |
Ovulation disorder | 22.83 | 9.63 | 7 | 150904 | 24 | 46535127 |
Conjunctival hyperaemia | 22.64 | 9.63 | 30 | 150881 | 1959 | 46533192 |
Gallbladder adenocarcinoma | 22.47 | 9.63 | 9 | 150902 | 78 | 46535073 |
Nausea | 22.45 | 9.63 | 1916 | 148995 | 685538 | 45849613 |
Live birth | 22.43 | 9.63 | 79 | 150832 | 10251 | 46524900 |
Neuropathy peripheral | 22.36 | 9.63 | 187 | 150724 | 90706 | 46444445 |
Clostridium difficile infection | 22.31 | 9.63 | 29 | 150882 | 25074 | 46510077 |
Infective pulmonary exacerbation of cystic fibrosis | 22.27 | 9.63 | 4 | 150907 | 10803 | 46524348 |
Tachycardia | 21.86 | 9.63 | 211 | 150700 | 99411 | 46435740 |
Adactyly | 21.80 | 9.63 | 7 | 150904 | 29 | 46535122 |
Wrong technique in product usage process | 21.79 | 9.63 | 96 | 150815 | 54326 | 46480825 |
Punctate keratitis | 21.77 | 9.63 | 17 | 150894 | 586 | 46534565 |
Necrotising fasciitis | 21.70 | 9.63 | 34 | 150877 | 2589 | 46532562 |
Blood glucose increased | 21.63 | 9.63 | 140 | 150771 | 71873 | 46463278 |
Injection site abscess | 21.55 | 9.63 | 21 | 150890 | 978 | 46534173 |
Hypomagnesaemia | 21.50 | 9.63 | 24 | 150887 | 22186 | 46512965 |
Pleural effusion | 21.16 | 9.63 | 169 | 150742 | 82783 | 46452368 |
Product quality issue | 21.08 | 9.63 | 53 | 150858 | 35595 | 46499556 |
Analgesic drug level increased | 20.94 | 9.63 | 25 | 150886 | 1469 | 46533682 |
Cognitive disorder | 20.92 | 9.63 | 56 | 150855 | 36827 | 46498324 |
Red blood cell sedimentation rate abnormal | 20.82 | 9.63 | 9 | 150902 | 13640 | 46521511 |
Pancreatitis | 20.64 | 9.63 | 72 | 150839 | 43555 | 46491596 |
Arteriovenous fistula occlusion | 20.61 | 9.63 | 13 | 150898 | 316 | 46534835 |
Cytomegalovirus infection | 20.60 | 9.63 | 17 | 150894 | 18127 | 46517024 |
Shock | 20.58 | 9.63 | 131 | 150780 | 21714 | 46513437 |
Unresponsive to stimuli | 20.49 | 9.63 | 46 | 150865 | 32128 | 46503023 |
Pneumonia aspiration | 20.28 | 9.63 | 45 | 150866 | 31560 | 46503591 |
Diabetes mellitus | 20.24 | 9.63 | 88 | 150823 | 49977 | 46485174 |
Torsade de pointes | 20.22 | 9.63 | 7 | 150904 | 12147 | 46523004 |
Gastric haemorrhage | 20.05 | 9.63 | 53 | 150858 | 5881 | 46529270 |
Vasoconstriction | 20.04 | 9.63 | 15 | 150896 | 485 | 46534666 |
Cyanosis neonatal | 19.98 | 9.63 | 11 | 150900 | 206 | 46534945 |
Blood potassium decreased | 19.96 | 9.63 | 60 | 150851 | 38003 | 46497148 |
Pain in extremity | 19.79 | 9.63 | 1024 | 149887 | 257656 | 46277495 |
Blue toe syndrome | 19.70 | 9.63 | 13 | 150898 | 342 | 46534809 |
Paranoia | 19.64 | 9.63 | 5 | 150906 | 10592 | 46524559 |
Urinoma | 19.41 | 9.63 | 7 | 150904 | 44 | 46535107 |
Rotator cuff repair | 19.40 | 9.63 | 24 | 150887 | 1463 | 46533688 |
Neuralgia | 19.39 | 9.63 | 127 | 150784 | 21256 | 46513895 |
Iron deficiency anaemia | 19.30 | 9.63 | 108 | 150803 | 17098 | 46518053 |
Gastrointestinal ulcer | 19.26 | 9.63 | 28 | 150883 | 1995 | 46533156 |
Myocardial infarction | 19.17 | 9.63 | 212 | 150699 | 97316 | 46437835 |
Colitis erosive | 19.16 | 9.63 | 8 | 150903 | 78 | 46535073 |
Condition aggravated | 19.14 | 9.63 | 972 | 149939 | 244080 | 46291071 |
Respiratory failure | 19.08 | 9.63 | 205 | 150706 | 94611 | 46440540 |
Musculoskeletal disorder | 19.08 | 9.63 | 100 | 150811 | 15445 | 46519706 |
Porphyria | 19.00 | 9.63 | 9 | 150902 | 121 | 46535030 |
Urine porphobilinogen increased | 18.95 | 9.63 | 4 | 150907 | 0 | 46535151 |
Abdominal pain upper | 18.94 | 9.63 | 609 | 150302 | 144696 | 46390455 |
Neoplasm progression | 18.81 | 9.63 | 36 | 150875 | 26647 | 46508504 |
Dry skin | 18.53 | 9.63 | 69 | 150842 | 40947 | 46494204 |
Gamma-glutamyltransferase increased | 18.46 | 9.63 | 170 | 150741 | 31570 | 46503581 |
Asthenia | 18.39 | 9.63 | 820 | 150091 | 310255 | 46224896 |
Kounis syndrome | 18.32 | 9.63 | 21 | 150890 | 1181 | 46533970 |
Lethargy | 18.30 | 9.63 | 94 | 150817 | 51077 | 46484074 |
Wound infection pseudomonas | 18.21 | 9.63 | 23 | 150888 | 1432 | 46533719 |
Anterior chamber cell | 18.18 | 9.63 | 15 | 150896 | 560 | 46534591 |
Arterial haemorrhage | 18.17 | 9.63 | 25 | 150886 | 1693 | 46533458 |
Laparotomy | 18.12 | 9.63 | 9 | 150902 | 135 | 46535016 |
Fluid overload | 18.03 | 9.63 | 38 | 150873 | 27147 | 46508004 |
Neurotoxicity | 18.01 | 9.63 | 11 | 150900 | 13706 | 46521445 |
Libido disorder | 17.86 | 9.63 | 7 | 150904 | 57 | 46535094 |
Bone marrow failure | 17.63 | 9.63 | 44 | 150867 | 29625 | 46505526 |
Device dislocation | 17.58 | 9.63 | 27 | 150884 | 21775 | 46513376 |
Palatal oedema | 17.57 | 9.63 | 14 | 150897 | 497 | 46534654 |
Status epilepticus | 17.28 | 9.63 | 12 | 150899 | 13967 | 46521184 |
Anuria | 17.23 | 9.63 | 78 | 150833 | 11353 | 46523798 |
Premature delivery | 17.16 | 9.63 | 28 | 150883 | 22041 | 46513110 |
Weight increased | 17.06 | 9.63 | 403 | 150508 | 164070 | 46371081 |
Homicide | 17.03 | 9.63 | 13 | 150898 | 433 | 46534718 |
Tenderness | 17.01 | 9.63 | 103 | 150808 | 16778 | 46518373 |
Transfusion | 16.84 | 9.63 | 11 | 150900 | 13220 | 46521931 |
Device issue | 16.83 | 9.63 | 24 | 150887 | 19956 | 46515195 |
Lipoedema | 16.81 | 9.63 | 9 | 150902 | 159 | 46534992 |
Pyoderma streptococcal | 16.72 | 9.63 | 4 | 150907 | 3 | 46535148 |
Synovial cyst | 16.66 | 9.63 | 57 | 150854 | 7289 | 46527862 |
Self-medication | 16.58 | 9.63 | 27 | 150884 | 2125 | 46533026 |
Progressive multifocal leukoencephalopathy | 16.50 | 9.63 | 8 | 150903 | 11338 | 46523813 |
Depression | 16.49 | 9.63 | 421 | 150490 | 169683 | 46365468 |
Viral upper respiratory tract infection | 16.40 | 9.63 | 55 | 150856 | 6963 | 46528188 |
Femur-fibula-ulna complex | 16.34 | 9.63 | 5 | 150906 | 17 | 46535134 |
Mucosal inflammation | 16.07 | 9.63 | 68 | 150843 | 38908 | 46496243 |
Adverse reaction | 15.98 | 9.63 | 60 | 150851 | 8030 | 46527121 |
Haemarthrosis | 15.96 | 9.63 | 32 | 150879 | 2961 | 46532190 |
Renal tubular necrosis | 15.91 | 9.63 | 73 | 150838 | 10686 | 46524465 |
Liver function test increased | 15.91 | 9.63 | 31 | 150880 | 22795 | 46512356 |
Congenital tricuspid valve atresia | 15.85 | 9.63 | 6 | 150905 | 44 | 46535107 |
Product administered at inappropriate site | 15.84 | 9.63 | 28 | 150883 | 2355 | 46532796 |
Peritonitis | 15.83 | 9.63 | 118 | 150793 | 20596 | 46514555 |
Aggression | 15.76 | 9.63 | 31 | 150880 | 22713 | 46512438 |
Face oedema | 15.72 | 9.63 | 111 | 150800 | 19042 | 46516109 |
Emotional distress | 15.68 | 9.63 | 49 | 150862 | 30658 | 46504493 |
Therapy non-responder | 15.64 | 9.63 | 74 | 150837 | 41078 | 46494073 |
Akathisia | 15.58 | 9.63 | 3 | 150908 | 7711 | 46527440 |
Anal erosion | 15.51 | 9.63 | 5 | 150906 | 21 | 46535130 |
Asthma | 15.33 | 9.63 | 206 | 150705 | 91336 | 46443815 |
Ulcerative keratitis | 15.32 | 9.63 | 27 | 150884 | 2266 | 46532885 |
Unevaluable event | 15.31 | 9.63 | 87 | 150824 | 46088 | 46489063 |
Tachyarrhythmia | 15.28 | 9.63 | 41 | 150870 | 4591 | 46530560 |
Mouth ulceration | 15.25 | 9.63 | 143 | 150768 | 26689 | 46508462 |
Abnormal behaviour | 15.20 | 9.63 | 28 | 150883 | 21030 | 46514121 |
Porphyrins urine increased | 15.15 | 9.63 | 5 | 150906 | 23 | 46535128 |
Acquired porphyria | 15.15 | 9.63 | 5 | 150906 | 23 | 46535128 |
Laboratory test abnormal | 15.10 | 9.63 | 32 | 150879 | 22815 | 46512336 |
Hypophagia | 15.09 | 9.63 | 153 | 150758 | 29153 | 46505998 |
Metastases to liver | 15.08 | 9.63 | 25 | 150886 | 19560 | 46515591 |
Extradural abscess | 15.05 | 9.63 | 15 | 150896 | 718 | 46534433 |
Bone density decreased | 15.04 | 9.63 | 67 | 150844 | 9685 | 46525466 |
Hypocalcaemia | 14.94 | 9.63 | 41 | 150870 | 26744 | 46508407 |
Complications of intestinal transplant | 14.93 | 9.63 | 4 | 150907 | 7 | 46535144 |
Oesophagitis ulcerative | 14.89 | 9.63 | 13 | 150898 | 525 | 46534626 |
Diverticulum intestinal | 14.70 | 9.63 | 48 | 150863 | 5993 | 46529158 |
Application site pain | 14.70 | 9.63 | 37 | 150874 | 3986 | 46531165 |
Linear IgA disease | 14.69 | 9.63 | 20 | 150891 | 1341 | 46533810 |
Tonsillitis | 14.46 | 9.63 | 42 | 150869 | 4922 | 46530229 |
Central pain syndrome | 14.41 | 9.63 | 9 | 150902 | 215 | 46534936 |
Abnormal loss of weight | 14.40 | 9.63 | 42 | 150869 | 4933 | 46530218 |
Muscle tone disorder | 14.40 | 9.63 | 7 | 150904 | 100 | 46535051 |
Oesophageal carcinoma recurrent | 14.34 | 9.63 | 5 | 150906 | 28 | 46535123 |
Sciatic nerve palsy | 14.34 | 9.63 | 5 | 150906 | 28 | 46535123 |
Seroma | 14.32 | 9.63 | 25 | 150886 | 2082 | 46533069 |
Asthenopia | 14.25 | 9.63 | 24 | 150887 | 1942 | 46533209 |
Injection site pain | 14.24 | 9.63 | 252 | 150659 | 106900 | 46428251 |
Application site eczema | 14.21 | 9.63 | 3 | 150908 | 0 | 46535151 |
Pseudodiverticular disease | 14.21 | 9.63 | 3 | 150908 | 0 | 46535151 |
Injection site hyperaesthesia | 14.20 | 9.63 | 5 | 150906 | 29 | 46535122 |
Epistaxis | 14.19 | 9.63 | 136 | 150775 | 64169 | 46470982 |
Injection site bruising | 14.18 | 9.63 | 63 | 150848 | 35573 | 46499578 |
Schizophrenia | 14.14 | 9.63 | 5 | 150906 | 8563 | 46526588 |
Juvenile idiopathic arthritis | 14.06 | 9.63 | 37 | 150874 | 4095 | 46531056 |
Porphyrins stool increased | 14.06 | 9.63 | 5 | 150906 | 30 | 46535121 |
Therapeutic product effect decreased | 14.02 | 9.63 | 358 | 150553 | 82243 | 46452908 |
Nail bed inflammation | 13.94 | 9.63 | 11 | 150900 | 385 | 46534766 |
Reticulocytosis | 13.92 | 9.63 | 7 | 150904 | 108 | 46535043 |
Hypochromic anaemia | 13.87 | 9.63 | 20 | 150891 | 1415 | 46533736 |
Sacroiliitis | 13.80 | 9.63 | 25 | 150886 | 2144 | 46533007 |
Alpha tumour necrosis factor increased | 13.79 | 9.63 | 5 | 150906 | 32 | 46535119 |
Upper gastrointestinal haemorrhage | 13.74 | 9.63 | 97 | 150814 | 16641 | 46518510 |
Ejection fraction decreased | 13.72 | 9.63 | 23 | 150888 | 17914 | 46517237 |
Axial spondyloarthritis | 13.69 | 9.63 | 7 | 150904 | 112 | 46535039 |
Pneumonitis chemical | 13.68 | 9.63 | 8 | 150903 | 169 | 46534982 |
Blood cholesterol increased | 13.60 | 9.63 | 193 | 150718 | 39820 | 46495331 |
Balance disorder | 13.59 | 9.63 | 138 | 150773 | 64383 | 46470768 |
Deep vein thrombosis | 13.54 | 9.63 | 179 | 150732 | 79594 | 46455557 |
Oesophageal adenocarcinoma | 13.51 | 9.63 | 8 | 150903 | 173 | 46534978 |
Extrapyramidal disorder | 13.50 | 9.63 | 10 | 150901 | 11258 | 46523893 |
Erythematotelangiectatic rosacea | 13.45 | 9.63 | 4 | 150907 | 12 | 46535139 |
Meteoropathy | 13.45 | 9.63 | 4 | 150907 | 12 | 46535139 |
Neurological procedural complication | 13.45 | 9.63 | 4 | 150907 | 12 | 46535139 |
Treatment noncompliance | 13.44 | 9.63 | 50 | 150861 | 29681 | 46505470 |
Extravascular haemolysis | 13.41 | 9.63 | 5 | 150906 | 35 | 46535116 |
Haematotoxicity | 13.38 | 9.63 | 3 | 150908 | 6930 | 46528221 |
Urosepsis | 13.38 | 9.63 | 18 | 150893 | 15335 | 46519816 |
Generalised tonic-clonic seizure | 13.34 | 9.63 | 44 | 150867 | 27078 | 46508073 |
Diabetic ketoacidosis | 13.34 | 9.63 | 24 | 150887 | 18186 | 46516965 |
Joint range of motion decreased | 13.21 | 9.63 | 89 | 150822 | 15035 | 46520116 |
Cardiac massage | 13.21 | 9.63 | 4 | 150907 | 13 | 46535138 |
Warm type haemolytic anaemia | 13.21 | 9.63 | 4 | 150907 | 13 | 46535138 |
Hallucination | 13.09 | 9.63 | 101 | 150810 | 49850 | 46485301 |
Muscle injury | 13.07 | 9.63 | 40 | 150871 | 4826 | 46530325 |
Application site ulcer | 13.06 | 9.63 | 7 | 150904 | 124 | 46535027 |
Peptic ulcer | 13.02 | 9.63 | 35 | 150876 | 3923 | 46531228 |
Pharyngo-oesophageal diverticulum | 12.98 | 9.63 | 4 | 150907 | 14 | 46535137 |
Eyelid oedema | 12.97 | 9.63 | 67 | 150844 | 10290 | 46524861 |
Small intestinal perforation | 12.96 | 9.63 | 18 | 150893 | 1230 | 46533921 |
Sopor | 12.91 | 9.63 | 28 | 150883 | 19800 | 46515351 |
Perforation bile duct | 12.77 | 9.63 | 4 | 150907 | 15 | 46535136 |
Insomnia | 12.76 | 9.63 | 421 | 150490 | 164503 | 46370648 |
Chest pain | 12.73 | 9.63 | 454 | 150457 | 175870 | 46359281 |
Jaundice | 12.72 | 9.63 | 146 | 150765 | 28699 | 46506452 |
Blood count abnormal | 12.70 | 9.63 | 24 | 150887 | 17854 | 46517297 |
Tenosynovitis | 12.64 | 9.63 | 53 | 150858 | 7462 | 46527689 |
Subdural haematoma | 12.63 | 9.63 | 14 | 150897 | 12983 | 46522168 |
Failure to thrive | 12.63 | 9.63 | 3 | 150908 | 6661 | 46528490 |
Abortion spontaneous | 12.52 | 9.63 | 86 | 150825 | 43560 | 46491591 |
Mania | 12.52 | 9.63 | 10 | 150901 | 10836 | 46524315 |
Underdose | 12.42 | 9.63 | 28 | 150883 | 19530 | 46515621 |
Injection site ulcer | 12.42 | 9.63 | 12 | 150899 | 553 | 46534598 |
Palmar-plantar erythrodysaesthesia syndrome | 12.41 | 9.63 | 30 | 150881 | 20421 | 46514730 |
Second primary malignancy | 12.41 | 9.63 | 3 | 150908 | 6581 | 46528570 |
Multiple sclerosis | 12.35 | 9.63 | 40 | 150871 | 24751 | 46510400 |
Application site injury | 12.32 | 9.63 | 5 | 150906 | 45 | 46535106 |
Parotid gland enlargement | 12.32 | 9.63 | 14 | 150897 | 780 | 46534371 |
Acute kidney injury | 12.30 | 9.63 | 903 | 150008 | 234952 | 46300199 |
Gestational diabetes | 12.28 | 9.63 | 4 | 150907 | 7215 | 46527936 |
Central nervous system lesion | 12.23 | 9.63 | 8 | 150903 | 9607 | 46525544 |
Papulopustular rosacea | 12.19 | 9.63 | 4 | 150907 | 18 | 46535133 |
Fistula discharge | 12.18 | 9.63 | 15 | 150896 | 910 | 46534241 |
Craniosynostosis | 12.17 | 9.63 | 7 | 150904 | 143 | 46535008 |
Bacteraemia | 11.98 | 9.63 | 17 | 150894 | 14162 | 46520989 |
Right ventricular failure | 11.97 | 9.63 | 21 | 150890 | 16072 | 46519079 |
Myocarditis | 11.97 | 9.63 | 5 | 150906 | 7734 | 46527417 |
Ventricular hypoplasia | 11.92 | 9.63 | 7 | 150904 | 149 | 46535002 |
Drug-induced liver injury | 11.91 | 9.63 | 130 | 150781 | 25238 | 46509913 |
Atrioventricular dissociation | 11.91 | 9.63 | 8 | 150903 | 217 | 46534934 |
Urticaria | 11.89 | 9.63 | 480 | 150431 | 117412 | 46417739 |
Blood alkaline phosphatase increased | 11.88 | 9.63 | 187 | 150724 | 39422 | 46495729 |
Amenorrhoea | 11.87 | 9.63 | 7 | 150904 | 8888 | 46526263 |
Thrombotic microangiopathy | 11.86 | 9.63 | 6 | 150905 | 8300 | 46526851 |
Atelectasis | 11.85 | 9.63 | 27 | 150884 | 18763 | 46516388 |
Nasal polypectomy | 11.85 | 9.63 | 4 | 150907 | 20 | 46535131 |
Tongue oedema | 11.77 | 9.63 | 34 | 150877 | 3972 | 46531179 |
Movement disorder | 11.77 | 9.63 | 94 | 150817 | 16755 | 46518396 |
Pulmonary oedema | 11.74 | 9.63 | 107 | 150804 | 50998 | 46484153 |
Arthritis bacterial | 11.72 | 9.63 | 43 | 150868 | 5693 | 46529458 |
Confusional state | 11.70 | 9.63 | 411 | 150500 | 159481 | 46375670 |
Enterococcal infection | 11.66 | 9.63 | 4 | 150907 | 6983 | 46528168 |
Haematochezia | 11.63 | 9.63 | 178 | 150733 | 37315 | 46497836 |
Iris transillumination defect | 11.61 | 9.63 | 5 | 150906 | 53 | 46535098 |
Ascites | 11.56 | 9.63 | 70 | 150841 | 36514 | 46498637 |
pH body fluid decreased | 11.54 | 9.63 | 4 | 150907 | 22 | 46535129 |
Pallor | 11.48 | 9.63 | 120 | 150791 | 23046 | 46512105 |
Ataxia | 11.47 | 9.63 | 17 | 150894 | 13913 | 46521238 |
Chest discomfort | 11.46 | 9.63 | 214 | 150697 | 90055 | 46445096 |
Chronic obstructive pulmonary disease | 11.43 | 9.63 | 125 | 150786 | 57508 | 46477643 |
Hypoproteinaemia | 11.42 | 9.63 | 21 | 150890 | 1822 | 46533329 |
Mucosal erosion | 11.40 | 9.63 | 18 | 150893 | 1380 | 46533771 |
Small intestinal stenosis | 11.35 | 9.63 | 11 | 150900 | 509 | 46534642 |
Lip oedema | 11.32 | 9.63 | 30 | 150881 | 3334 | 46531817 |
Peritonitis bacterial | 11.28 | 9.63 | 7 | 150904 | 8646 | 46526505 |
Fear | 11.24 | 9.63 | 22 | 150889 | 16150 | 46519001 |
Intervertebral discitis | 11.06 | 9.63 | 25 | 150886 | 2514 | 46532637 |
Gastroduodenal ulcer | 11.03 | 9.63 | 7 | 150904 | 172 | 46534979 |
Head titubation | 11.00 | 9.63 | 12 | 150899 | 639 | 46534512 |
Anaemia | 11.00 | 9.63 | 696 | 150215 | 255083 | 46280068 |
Libido increased | 10.95 | 9.63 | 13 | 150898 | 759 | 46534392 |
Psychotic disorder | 10.92 | 9.63 | 37 | 150874 | 22584 | 46512567 |
Stress ulcer | 10.91 | 9.63 | 5 | 150906 | 62 | 46535089 |
Microcytic anaemia | 10.81 | 9.63 | 28 | 150883 | 3070 | 46532081 |
Peritoneal tuberculosis | 10.78 | 9.63 | 11 | 150900 | 542 | 46534609 |
Small intestinal haemorrhage | 10.76 | 9.63 | 21 | 150890 | 1905 | 46533246 |
Uterine perforation | 10.76 | 9.63 | 5 | 150906 | 7262 | 46527889 |
Sebaceous gland infection | 10.73 | 9.63 | 6 | 150905 | 116 | 46535035 |
Agonal rhythm | 10.72 | 9.63 | 4 | 150907 | 28 | 46535123 |
Dermatitis bullous | 10.67 | 9.63 | 51 | 150860 | 7592 | 46527559 |
Heart rate increased | 10.55 | 9.63 | 174 | 150737 | 74617 | 46460534 |
Hepatic failure | 10.53 | 9.63 | 64 | 150847 | 33352 | 46501799 |
Acute generalised exanthematous pustulosis | 10.52 | 9.63 | 59 | 150852 | 9346 | 46525805 |
Blood glucose decreased | 10.48 | 9.63 | 29 | 150882 | 18863 | 46516288 |
Gastrointestinal hypermotility | 10.46 | 9.63 | 6 | 150905 | 122 | 46535029 |
Intestinal obstruction | 10.44 | 9.63 | 46 | 150865 | 26029 | 46509122 |
Small intestine carcinoma | 10.42 | 9.63 | 8 | 150903 | 269 | 46534882 |
Dyspnoea exertional | 10.41 | 9.63 | 108 | 150803 | 50181 | 46484970 |
Inclusion body myositis | 10.34 | 9.63 | 3 | 150908 | 8 | 46535143 |
Agitation | 10.28 | 9.63 | 122 | 150789 | 55293 | 46479858 |
Documented hypersensitivity to administered product | 10.26 | 9.63 | 11 | 150900 | 574 | 46534577 |
Erosive duodenitis | 10.26 | 9.63 | 10 | 150901 | 466 | 46534685 |
Salivary hypersecretion | 10.23 | 9.63 | 4 | 150907 | 6441 | 46528710 |
Application site erythema | 10.22 | 9.63 | 37 | 150874 | 4867 | 46530284 |
Endoscopy | 10.21 | 9.63 | 8 | 150903 | 277 | 46534874 |
Ventricular tachycardia | 10.21 | 9.63 | 25 | 150886 | 16942 | 46518209 |
Neutropenic sepsis | 10.19 | 9.63 | 15 | 150896 | 12309 | 46522842 |
Drug abuse | 10.14 | 9.63 | 144 | 150767 | 63264 | 46471887 |
Lordosis | 10.12 | 9.63 | 8 | 150903 | 281 | 46534870 |
Autoimmune hepatitis | 10.10 | 9.63 | 51 | 150860 | 7763 | 46527388 |
Osteochondrosis | 10.08 | 9.63 | 14 | 150897 | 956 | 46534195 |
Necrolytic migratory erythema | 10.08 | 9.63 | 3 | 150908 | 9 | 46535142 |
Laryngeal dyspnoea | 10.08 | 9.63 | 6 | 150905 | 131 | 46535020 |
Oxygen saturation decreased | 10.06 | 9.63 | 160 | 150751 | 69004 | 46466147 |
Breast cancer metastatic | 10.04 | 9.63 | 18 | 150893 | 13660 | 46521491 |
Lividity | 9.98 | 9.63 | 7 | 150904 | 204 | 46534947 |
Gastrointestinal amyloidosis | 9.95 | 9.63 | 5 | 150906 | 77 | 46535074 |
Metastases to central nervous system | 9.93 | 9.63 | 13 | 150898 | 11208 | 46523943 |
Radial nerve palsy | 9.93 | 9.63 | 9 | 150902 | 382 | 46534769 |
Dysphagia | 9.90 | 9.63 | 183 | 150728 | 77129 | 46458022 |
Nasal disorder | 9.86 | 9.63 | 22 | 150889 | 2192 | 46532959 |
Faeces discoloured | 9.80 | 9.63 | 90 | 150821 | 16697 | 46518454 |
Mucosa vesicle | 9.76 | 9.63 | 4 | 150907 | 37 | 46535114 |
Intestinal haemorrhage | 9.74 | 9.63 | 27 | 150884 | 3081 | 46532070 |
Psychomotor hyperactivity | 9.74 | 9.63 | 10 | 150901 | 9603 | 46525548 |
Hyperchromic anaemia | 9.67 | 9.63 | 4 | 150907 | 38 | 46535113 |
Hiatus hernia | 9.64 | 9.63 | 96 | 150815 | 18206 | 46516945 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Death | 250.46 | 10.12 | 275 | 68934 | 357008 | 29526261 |
Embolia cutis medicamentosa | 245.90 | 10.12 | 63 | 69146 | 141 | 29883128 |
Melaena | 202.63 | 10.12 | 308 | 68901 | 32129 | 29851140 |
Gastric ulcer | 198.21 | 10.12 | 208 | 69001 | 14913 | 29868356 |
Ankylosing spondylitis | 138.40 | 10.12 | 101 | 69108 | 4433 | 29878836 |
Duodenal ulcer | 131.18 | 10.12 | 137 | 69072 | 9764 | 29873505 |
Onychoclasis | 128.55 | 10.12 | 67 | 69142 | 1592 | 29881677 |
Arthralgia | 103.33 | 10.12 | 600 | 68609 | 135191 | 29748078 |
Kounis syndrome | 102.97 | 10.12 | 58 | 69151 | 1615 | 29881654 |
Large intestinal stenosis | 101.22 | 10.12 | 52 | 69157 | 1198 | 29882071 |
Inflammation | 94.62 | 10.12 | 177 | 69032 | 21849 | 29861420 |
Febrile neutropenia | 89.89 | 10.12 | 69 | 69140 | 106624 | 29776645 |
Gastric ulcer haemorrhage | 89.84 | 10.12 | 84 | 69125 | 5230 | 29878039 |
Large intestinal ulcer | 81.52 | 10.12 | 50 | 69159 | 1636 | 29881633 |
Anaphylactic shock | 79.15 | 10.12 | 127 | 69082 | 13866 | 29869403 |
Gastritis erosive | 78.56 | 10.12 | 80 | 69129 | 5533 | 29877736 |
Angioedema | 75.65 | 10.12 | 212 | 68997 | 34172 | 29849097 |
Tooth loss | 75.44 | 10.12 | 67 | 69142 | 3902 | 29879367 |
Neutropenia | 73.13 | 10.12 | 115 | 69094 | 128425 | 29754844 |
Lymphoma | 71.66 | 10.12 | 102 | 69107 | 10019 | 29873250 |
Urticaria | 67.95 | 10.12 | 278 | 68931 | 54328 | 29828941 |
Gastric haemorrhage | 67.90 | 10.12 | 96 | 69113 | 9371 | 29873898 |
Cardiac failure congestive | 65.63 | 10.12 | 59 | 69150 | 84348 | 29798921 |
Pain | 65.25 | 10.12 | 647 | 68562 | 171994 | 29711275 |
Intestinal diaphragm disease | 65.20 | 10.12 | 24 | 69185 | 235 | 29883034 |
Psoriatic arthropathy | 64.40 | 10.12 | 124 | 69085 | 15637 | 29867632 |
Off label use | 63.19 | 10.12 | 329 | 68880 | 248961 | 29634308 |
Anaphylactic reaction | 63.00 | 10.12 | 174 | 69035 | 27808 | 29855461 |
Pruritus | 59.62 | 10.12 | 472 | 68737 | 117732 | 29765537 |
Plasma cell myeloma | 58.66 | 10.12 | 25 | 69184 | 53437 | 29829832 |
Macrocephaly | 58.38 | 10.12 | 24 | 69185 | 323 | 29882946 |
Joint swelling | 56.04 | 10.12 | 236 | 68973 | 46710 | 29836559 |
Type I hypersensitivity | 56.01 | 10.12 | 32 | 69177 | 916 | 29882353 |
Pyloric stenosis | 55.34 | 10.12 | 27 | 69182 | 555 | 29882714 |
Arthritis | 55.19 | 10.12 | 152 | 69057 | 24249 | 29859020 |
Gastric ulcer perforation | 52.59 | 10.12 | 30 | 69179 | 856 | 29882413 |
Acute kidney injury | 51.43 | 10.12 | 903 | 68306 | 272939 | 29610330 |
Metastases to stomach | 50.77 | 10.12 | 15 | 69194 | 67 | 29883202 |
Thrombocytopenia | 50.40 | 10.12 | 156 | 69053 | 136888 | 29746381 |
Application site rash | 49.02 | 10.12 | 28 | 69181 | 801 | 29882468 |
Toxicity to various agents | 48.18 | 10.12 | 228 | 68981 | 176955 | 29706314 |
Duodenal ulcer perforation | 47.84 | 10.12 | 36 | 69173 | 1656 | 29881613 |
Atrial fibrillation | 47.32 | 10.12 | 113 | 69096 | 108011 | 29775258 |
Cerebrovascular accident | 45.27 | 10.12 | 77 | 69132 | 83400 | 29799869 |
Abdominal pain upper | 44.64 | 10.12 | 272 | 68937 | 62279 | 29820990 |
C-reactive protein increased | 43.93 | 10.12 | 208 | 69001 | 43265 | 29840004 |
Erythema | 42.77 | 10.12 | 316 | 68893 | 77135 | 29806134 |
Alopecia | 41.55 | 10.12 | 118 | 69091 | 19157 | 29864112 |
Muscle swelling | 40.54 | 10.12 | 19 | 69190 | 356 | 29882913 |
Haematemesis | 39.64 | 10.12 | 142 | 69067 | 26061 | 29857208 |
Mucosal erosion | 39.58 | 10.12 | 24 | 69185 | 769 | 29882500 |
Product dose omission issue | 38.33 | 10.12 | 98 | 69111 | 91533 | 29791736 |
Gastrointestinal erosion | 38.08 | 10.12 | 18 | 69191 | 344 | 29882925 |
Nephrotic syndrome | 36.91 | 10.12 | 61 | 69148 | 6824 | 29876445 |
Seronegative arthritis | 36.50 | 10.12 | 23 | 69186 | 790 | 29882479 |
Neoplasm malignant | 36.41 | 10.12 | 107 | 69102 | 17707 | 29865562 |
Drug tolerance decreased | 36.25 | 10.12 | 26 | 69183 | 1110 | 29882159 |
Glomerulonephritis minimal lesion | 35.78 | 10.12 | 18 | 69191 | 396 | 29882873 |
Musculoskeletal stiffness | 35.76 | 10.12 | 171 | 69038 | 35710 | 29847559 |
Hospitalisation | 35.61 | 10.12 | 30 | 69179 | 44289 | 29838980 |
Sacroiliitis | 35.31 | 10.12 | 23 | 69186 | 837 | 29882432 |
Injection site necrosis | 33.51 | 10.12 | 17 | 69192 | 381 | 29882888 |
Antidepressant drug level above therapeutic | 33.19 | 10.12 | 13 | 69196 | 153 | 29883116 |
Disease progression | 32.96 | 10.12 | 86 | 69123 | 79788 | 29803481 |
Toxic epidermal necrolysis | 32.23 | 10.12 | 103 | 69106 | 17837 | 29865432 |
Pneumonia | 32.02 | 10.12 | 562 | 68647 | 333744 | 29549525 |
Ulcerative keratitis | 31.61 | 10.12 | 26 | 69183 | 1363 | 29881906 |
Neck pain | 31.25 | 10.12 | 113 | 69096 | 20831 | 29862438 |
Haematochezia | 31.19 | 10.12 | 159 | 69050 | 34063 | 29849206 |
Corneal thinning | 31.04 | 10.12 | 12 | 69197 | 136 | 29883133 |
Peptic ulcer | 30.89 | 10.12 | 35 | 69174 | 2733 | 29880536 |
Mastoid abscess | 30.44 | 10.12 | 6 | 69203 | 0 | 29883269 |
Blood pressure measurement | 30.28 | 10.12 | 12 | 69197 | 146 | 29883123 |
Swelling | 29.94 | 10.12 | 163 | 69046 | 35812 | 29847457 |
Erosive duodenitis | 29.16 | 10.12 | 25 | 69184 | 1388 | 29881881 |
Aspirin-exacerbated respiratory disease | 28.94 | 10.12 | 15 | 69194 | 352 | 29882917 |
Periorbital oedema | 28.84 | 10.12 | 37 | 69172 | 3289 | 29879980 |
Duodenal ulcer haemorrhage | 28.63 | 10.12 | 44 | 69165 | 4628 | 29878641 |
Analgesic drug level above therapeutic | 28.31 | 10.12 | 13 | 69196 | 232 | 29883037 |
Ligament calcification | 28.27 | 10.12 | 9 | 69200 | 54 | 29883215 |
Bronchospasm | 28.09 | 10.12 | 69 | 69140 | 10269 | 29873000 |
Platelet dysfunction | 27.78 | 10.12 | 12 | 69197 | 184 | 29883085 |
Cardiac septal defect | 27.72 | 10.12 | 12 | 69197 | 185 | 29883084 |
Conjunctival hyperaemia | 27.60 | 10.12 | 30 | 69179 | 2237 | 29881032 |
Faeces discoloured | 26.83 | 10.12 | 82 | 69127 | 13864 | 29869405 |
Microcytic anaemia | 26.83 | 10.12 | 29 | 69180 | 2149 | 29881120 |
Sciatic nerve palsy | 26.29 | 10.12 | 6 | 69203 | 6 | 29883263 |
Tubulointerstitial nephritis | 26.24 | 10.12 | 96 | 69113 | 17795 | 29865474 |
Malignant mesenteric neoplasm | 25.71 | 10.12 | 8 | 69201 | 44 | 29883225 |
Weight bearing difficulty | 25.59 | 10.12 | 19 | 69190 | 856 | 29882413 |
Renal failure neonatal | 25.52 | 10.12 | 9 | 69200 | 77 | 29883192 |
Sepsis | 25.49 | 10.12 | 216 | 68993 | 146179 | 29737090 |
Hypotension | 25.45 | 10.12 | 319 | 68890 | 200246 | 29683023 |
Lymphocyte stimulation test positive | 25.44 | 10.12 | 19 | 69190 | 864 | 29882405 |
Cerebral atrophy congenital | 25.41 | 10.12 | 8 | 69201 | 46 | 29883223 |
Nerve stimulation test abnormal | 25.36 | 10.12 | 5 | 69204 | 0 | 29883269 |
Hypomagnesaemia | 25.32 | 10.12 | 4 | 69205 | 16594 | 29866675 |
Body mass index abnormal | 25.32 | 10.12 | 9 | 69200 | 79 | 29883190 |
Grip strength decreased | 25.20 | 10.12 | 28 | 69181 | 2140 | 29881129 |
Completed suicide | 24.73 | 10.12 | 132 | 69077 | 99360 | 29783909 |
Erythema multiforme | 24.64 | 10.12 | 56 | 69153 | 7929 | 29875340 |
Gingivitis ulcerative | 24.58 | 10.12 | 8 | 69201 | 52 | 29883217 |
Corneal epithelium defect | 24.45 | 10.12 | 13 | 69196 | 322 | 29882947 |
Back pain | 24.31 | 10.12 | 352 | 68857 | 102244 | 29781025 |
Mental status changes | 24.22 | 10.12 | 30 | 69179 | 37049 | 29846220 |
Blood lactate dehydrogenase increased | 24.13 | 10.12 | 103 | 69106 | 20498 | 29862771 |
Keratopathy | 24.12 | 10.12 | 11 | 69198 | 193 | 29883076 |
Blister | 23.91 | 10.12 | 103 | 69106 | 20580 | 29862689 |
Sciatic nerve injury | 23.85 | 10.12 | 9 | 69200 | 95 | 29883174 |
Fatigue | 23.83 | 10.12 | 562 | 68647 | 320111 | 29563158 |
Mast cell activation syndrome | 23.68 | 10.12 | 9 | 69200 | 97 | 29883172 |
Application site swelling | 23.57 | 10.12 | 12 | 69197 | 271 | 29882998 |
Shock | 23.54 | 10.12 | 110 | 69099 | 22749 | 29860520 |
Duodenal stenosis | 23.47 | 10.12 | 11 | 69198 | 206 | 29883063 |
Electrocardiogram QT prolonged | 23.40 | 10.12 | 29 | 69180 | 35806 | 29847463 |
Spinal pain | 23.19 | 10.12 | 39 | 69170 | 4425 | 29878844 |
Cytomegalovirus infection | 23.03 | 10.12 | 13 | 69196 | 23661 | 29859608 |
Factor VIII deficiency | 22.82 | 10.12 | 9 | 69200 | 108 | 29883161 |
Psoriasis | 22.63 | 10.12 | 172 | 69037 | 42334 | 29840935 |
Jejunal ulcer perforation | 22.52 | 10.12 | 8 | 69201 | 70 | 29883199 |
Product administered at inappropriate site | 22.33 | 10.12 | 23 | 69186 | 1612 | 29881657 |
Pancytopenia | 22.17 | 10.12 | 111 | 69098 | 84941 | 29798328 |
Disability | 22.16 | 10.12 | 38 | 69171 | 4380 | 29878889 |
Pulmonary embolism | 22.11 | 10.12 | 99 | 69110 | 78036 | 29805233 |
Blood urea increased | 22.07 | 10.12 | 136 | 69073 | 31245 | 29852024 |
Hypoaldosteronism | 21.95 | 10.12 | 10 | 69199 | 175 | 29883094 |
Tachycardia | 21.73 | 10.12 | 92 | 69117 | 73647 | 29809622 |
Rheumatoid arthritis | 21.54 | 10.12 | 166 | 69043 | 41031 | 29842238 |
Oral pruritus | 21.43 | 10.12 | 11 | 69198 | 253 | 29883016 |
Incorrect product administration duration | 21.36 | 10.12 | 35 | 69174 | 3887 | 29879382 |
Uveitis | 21.04 | 10.12 | 42 | 69167 | 5435 | 29877834 |
Kidney duplex | 20.99 | 10.12 | 12 | 69197 | 344 | 29882925 |
Gastrointestinal haemorrhage | 20.84 | 10.12 | 289 | 68920 | 83157 | 29800112 |
Fluid overload | 20.82 | 10.12 | 9 | 69200 | 19083 | 29864186 |
Deep vein thrombosis | 20.73 | 10.12 | 71 | 69138 | 60430 | 29822839 |
Subacute endocarditis | 20.71 | 10.12 | 7 | 69202 | 52 | 29883217 |
Joint space narrowing | 20.59 | 10.12 | 7 | 69202 | 53 | 29883216 |
Corneal perforation | 20.54 | 10.12 | 9 | 69200 | 143 | 29883126 |
Gastritis haemorrhagic | 20.53 | 10.12 | 19 | 69190 | 1167 | 29882102 |
Upper gastrointestinal haemorrhage | 20.52 | 10.12 | 103 | 69106 | 21925 | 29861344 |
Cardio-respiratory arrest | 20.49 | 10.12 | 66 | 69143 | 57240 | 29826029 |
Necrotising fasciitis | 20.46 | 10.12 | 32 | 69177 | 3417 | 29879852 |
Physical examination abnormal | 20.43 | 10.12 | 8 | 69201 | 94 | 29883175 |
Drug interaction | 20.30 | 10.12 | 604 | 68605 | 198964 | 29684305 |
Secondary amyloidosis | 20.26 | 10.12 | 7 | 69202 | 56 | 29883213 |
Intervertebral disc compression | 20.14 | 10.12 | 11 | 69198 | 288 | 29882981 |
Oropharyngeal discomfort | 19.99 | 10.12 | 21 | 69188 | 1506 | 29881763 |
Eastern Cooperative Oncology Group performance status | 19.75 | 10.12 | 6 | 69203 | 30 | 29883239 |
Omental necrosis | 19.75 | 10.12 | 6 | 69203 | 30 | 29883239 |
Platelet function test abnormal | 19.44 | 10.12 | 8 | 69201 | 108 | 29883161 |
Mesenteric neoplasm | 19.44 | 10.12 | 6 | 69203 | 32 | 29883237 |
Pupils unequal | 19.28 | 10.12 | 19 | 69190 | 1263 | 29882006 |
Tissue infiltration | 19.25 | 10.12 | 7 | 69202 | 66 | 29883203 |
Hypoglycaemia | 18.73 | 10.12 | 58 | 69151 | 50923 | 29832346 |
Suicide attempt | 18.70 | 10.12 | 147 | 69062 | 36550 | 29846719 |
Metastases to lung | 18.66 | 10.12 | 50 | 69159 | 7845 | 29875424 |
Contraindicated product administered | 18.54 | 10.12 | 84 | 69125 | 17147 | 29866122 |
Leukopenia | 18.50 | 10.12 | 67 | 69142 | 56092 | 29827177 |
Anuria | 18.32 | 10.12 | 59 | 69150 | 10257 | 29873012 |
Hypoosmolar state | 18.29 | 10.12 | 7 | 69202 | 77 | 29883192 |
Palmoplantar pustulosis | 18.21 | 10.12 | 7 | 69202 | 78 | 29883191 |
Seizure | 18.17 | 10.12 | 143 | 69066 | 98332 | 29784937 |
Intestinal ulcer | 18.11 | 10.12 | 15 | 69194 | 794 | 29882475 |
Musculoskeletal pain | 18.07 | 10.12 | 128 | 69081 | 30812 | 29852457 |
Fibromyalgia | 17.96 | 10.12 | 26 | 69183 | 2592 | 29880677 |
Leptotrichia infection | 17.90 | 10.12 | 7 | 69202 | 82 | 29883187 |
Deafness congenital | 17.82 | 10.12 | 6 | 69203 | 44 | 29883225 |
Cryopyrin associated periodic syndrome | 17.82 | 10.12 | 6 | 69203 | 44 | 29883225 |
Nasopharyngitis | 17.73 | 10.12 | 211 | 68998 | 58638 | 29824631 |
Eschar | 17.62 | 10.12 | 13 | 69196 | 580 | 29882689 |
Persistent corneal epithelial defect | 17.36 | 10.12 | 5 | 69204 | 20 | 29883249 |
Acute myeloid leukaemia | 17.36 | 10.12 | 10 | 69199 | 17996 | 29865273 |
Tonsil cancer | 16.69 | 10.12 | 14 | 69195 | 754 | 29882515 |
Skin necrosis | 16.69 | 10.12 | 35 | 69174 | 4692 | 29878577 |
Bacteroides infection | 16.65 | 10.12 | 7 | 69202 | 100 | 29883169 |
Oligoarthritis | 16.65 | 10.12 | 6 | 69203 | 55 | 29883214 |
Twin pregnancy | 16.64 | 10.12 | 4 | 69205 | 6 | 29883263 |
Abdominal pain | 16.43 | 10.12 | 420 | 68789 | 135234 | 29748035 |
Neurotoxicity | 16.43 | 10.12 | 5 | 69204 | 13177 | 29870092 |
Double stranded DNULL antibody positive | 16.40 | 10.12 | 7 | 69202 | 104 | 29883165 |
Respiratory failure | 16.39 | 10.12 | 151 | 69058 | 100491 | 29782778 |
Ductus arteriosus premature closure | 16.34 | 10.12 | 7 | 69202 | 105 | 29883164 |
Gastric mucosal lesion | 16.29 | 10.12 | 12 | 69197 | 534 | 29882735 |
Rash erythematous | 16.23 | 10.12 | 98 | 69111 | 22354 | 29860915 |
Full blood count decreased | 16.22 | 10.12 | 8 | 69201 | 15709 | 29867560 |
Gastrointestinal ulcer | 16.18 | 10.12 | 20 | 69189 | 1712 | 29881557 |
Gastric mucosa erythema | 16.16 | 10.12 | 9 | 69200 | 245 | 29883024 |
Iris hypopigmentation | 16.14 | 10.12 | 5 | 69204 | 27 | 29883242 |
Medium-chain acyl-coenzyme A dehydrogenase deficiency | 16.14 | 10.12 | 5 | 69204 | 27 | 29883242 |
Application site reaction | 16.12 | 10.12 | 11 | 69198 | 433 | 29882836 |
Pain in extremity | 16.02 | 10.12 | 350 | 68859 | 109871 | 29773398 |
Fragile X syndrome | 15.99 | 10.12 | 5 | 69204 | 28 | 29883241 |
Application site erythema | 15.99 | 10.12 | 23 | 69186 | 2280 | 29880989 |
Myelodysplastic syndrome | 15.97 | 10.12 | 12 | 69197 | 18766 | 29864503 |
Lentigo maligna | 15.96 | 10.12 | 9 | 69200 | 251 | 29883018 |
Ureteral disorder | 15.95 | 10.12 | 8 | 69201 | 175 | 29883094 |
Melanaemia | 15.91 | 10.12 | 4 | 69205 | 8 | 29883261 |
Spondyloarthropathy | 15.86 | 10.12 | 11 | 69198 | 445 | 29882824 |
Gastritis | 15.79 | 10.12 | 90 | 69119 | 20108 | 29863161 |
Neuroleptic malignant syndrome | 15.78 | 10.12 | 9 | 69200 | 16286 | 29866983 |
Soft tissue infection | 15.75 | 10.12 | 19 | 69190 | 1586 | 29881683 |
Energy increased | 15.73 | 10.12 | 17 | 69192 | 1259 | 29882010 |
Endoscopy abnormal | 15.60 | 10.12 | 4 | 69205 | 9 | 29883260 |
Ciliary hyperaemia | 15.56 | 10.12 | 5 | 69204 | 31 | 29883238 |
Gout | 15.46 | 10.12 | 80 | 69129 | 17235 | 29866034 |
Inflammatory marker increased | 15.44 | 10.12 | 27 | 69182 | 3161 | 29880108 |
Renal tubular necrosis | 15.42 | 10.12 | 73 | 69136 | 15178 | 29868091 |
Application site vesicles | 15.41 | 10.12 | 12 | 69197 | 581 | 29882688 |
Application site eczema | 15.30 | 10.12 | 4 | 69205 | 10 | 29883259 |
Pallor | 15.29 | 10.12 | 92 | 69117 | 20957 | 29862312 |
Internal limiting membrane peeling | 15.22 | 10.12 | 3 | 69206 | 0 | 29883269 |
Leucine aminopeptidase increased | 15.22 | 10.12 | 3 | 69206 | 0 | 29883269 |
Urinary tract infection | 15.00 | 10.12 | 104 | 69105 | 73555 | 29809714 |
Ultrasound skull abnormal | 14.85 | 10.12 | 6 | 69203 | 77 | 29883192 |
CADASIL | 14.85 | 10.12 | 6 | 69203 | 77 | 29883192 |
Retroperitoneal fibrosis | 14.77 | 10.12 | 9 | 69200 | 291 | 29882978 |
Retinal toxicity | 14.76 | 10.12 | 10 | 69199 | 389 | 29882880 |
Mallory-Weiss syndrome | 14.68 | 10.12 | 17 | 69192 | 1359 | 29881910 |
Inflammatory bowel disease | 14.62 | 10.12 | 22 | 69187 | 2271 | 29880998 |
Magnetic resonance imaging spinal abnormal | 14.58 | 10.12 | 6 | 69203 | 81 | 29883188 |
Gastrointestinal wall thickening | 14.50 | 10.12 | 14 | 69195 | 907 | 29882362 |
Wound secretion | 14.50 | 10.12 | 23 | 69186 | 2485 | 29880784 |
Oligohydramnios | 14.50 | 10.12 | 9 | 69200 | 301 | 29882968 |
Tubulointerstitial nephritis and uveitis syndrome | 14.47 | 10.12 | 5 | 69204 | 40 | 29883229 |
Oropharyngeal pain | 14.44 | 10.12 | 114 | 69095 | 28382 | 29854887 |
Microcephaly | 14.41 | 10.12 | 12 | 69197 | 640 | 29882629 |
Acquired haemophilia | 14.39 | 10.12 | 13 | 69196 | 774 | 29882495 |
Axillary pain | 14.32 | 10.12 | 8 | 69201 | 219 | 29883050 |
Neisseria infection | 14.31 | 10.12 | 4 | 69205 | 14 | 29883255 |
Visual evoked potentials abnormal | 14.25 | 10.12 | 6 | 69203 | 86 | 29883183 |
Nikolsky's sign | 14.23 | 10.12 | 8 | 69201 | 222 | 29883047 |
Skin ulcer | 14.09 | 10.12 | 83 | 69126 | 18766 | 29864503 |
Ulcer | 14.08 | 10.12 | 41 | 69168 | 6750 | 29876519 |
Procalcitonin increased | 13.97 | 10.12 | 15 | 69194 | 1103 | 29882166 |
Oral mucosa erosion | 13.96 | 10.12 | 13 | 69196 | 805 | 29882464 |
Intestinal metastasis | 13.92 | 10.12 | 7 | 69202 | 154 | 29883115 |
Xanthelasma | 13.72 | 10.12 | 6 | 69203 | 95 | 29883174 |
Tumour invasion | 13.66 | 10.12 | 9 | 69200 | 334 | 29882935 |
Dehydration | 13.65 | 10.12 | 202 | 69007 | 123337 | 29759932 |
White blood cell count decreased | 13.64 | 10.12 | 126 | 69083 | 83821 | 29799448 |
Trisomy 8 | 13.58 | 10.12 | 5 | 69204 | 49 | 29883220 |
Corneal opacity | 13.51 | 10.12 | 11 | 69198 | 568 | 29882701 |
Ecthyma | 13.45 | 10.12 | 9 | 69200 | 343 | 29882926 |
Ductus arteriosus stenosis foetal | 13.44 | 10.12 | 6 | 69203 | 100 | 29883169 |
Desmoid tumour | 13.44 | 10.12 | 6 | 69203 | 100 | 29883169 |
Arthritis bacterial | 13.43 | 10.12 | 31 | 69178 | 4433 | 29878836 |
Central nervous system inflammation | 13.33 | 10.12 | 6 | 69203 | 102 | 29883167 |
Lipid metabolism disorder | 13.26 | 10.12 | 8 | 69201 | 254 | 29883015 |
Oculomucocutaneous syndrome | 13.25 | 10.12 | 7 | 69202 | 171 | 29883098 |
Thrombosis mesenteric vessel | 13.23 | 10.12 | 5 | 69204 | 53 | 29883216 |
Dermatosis | 13.20 | 10.12 | 8 | 69201 | 256 | 29883013 |
Neuropathy peripheral | 13.15 | 10.12 | 102 | 69107 | 70373 | 29812896 |
Peritonsillitis | 13.15 | 10.12 | 3 | 69206 | 3 | 29883266 |
Myofascial pain syndrome | 13.13 | 10.12 | 9 | 69200 | 357 | 29882912 |
Duodenal perforation | 13.06 | 10.12 | 15 | 69194 | 1189 | 29882080 |
Musculoskeletal discomfort | 13.02 | 10.12 | 38 | 69171 | 6262 | 29877007 |
Pharyngitis | 12.95 | 10.12 | 40 | 69169 | 6802 | 29876467 |
Large intestine perforation | 12.90 | 10.12 | 43 | 69166 | 7608 | 29875661 |
Skin erosion | 12.90 | 10.12 | 18 | 69191 | 1735 | 29881534 |
Diarrhoea | 12.89 | 10.12 | 636 | 68573 | 333467 | 29549802 |
Drug reaction with eosinophilia and systemic symptoms | 12.84 | 10.12 | 111 | 69098 | 28377 | 29854892 |
Gastric bypass | 12.77 | 10.12 | 8 | 69201 | 272 | 29882997 |
Noninfective gingivitis | 12.77 | 10.12 | 8 | 69201 | 272 | 29882997 |
Duodenal obstruction | 12.73 | 10.12 | 6 | 69203 | 114 | 29883155 |
Hypoxia | 12.72 | 10.12 | 62 | 69147 | 47792 | 29835477 |
Angiocardiogram | 12.72 | 10.12 | 7 | 69202 | 186 | 29883083 |
Application site exfoliation | 12.68 | 10.12 | 6 | 69203 | 115 | 29883154 |
Rash | 12.64 | 10.12 | 553 | 68656 | 191336 | 29691933 |
Bradycardia | 12.62 | 10.12 | 94 | 69115 | 65432 | 29817837 |
Linear IgA disease | 12.62 | 10.12 | 17 | 69192 | 1585 | 29881684 |
Discoloured vomit | 12.61 | 10.12 | 9 | 69200 | 381 | 29882888 |
Poisoning deliberate | 12.58 | 10.12 | 36 | 69173 | 5868 | 29877401 |
Unevaluable event | 12.51 | 10.12 | 35 | 69174 | 31750 | 29851519 |
Ejection fraction | 12.46 | 10.12 | 5 | 69204 | 63 | 29883206 |
Application site oedema | 12.42 | 10.12 | 4 | 69205 | 25 | 29883244 |
Eye pain | 12.33 | 10.12 | 57 | 69152 | 11732 | 29871537 |
Intentional product use issue | 12.32 | 10.12 | 43 | 69166 | 36397 | 29846872 |
Laryngeal oedema | 12.24 | 10.12 | 25 | 69184 | 3289 | 29879980 |
Peritonitis | 12.23 | 10.12 | 88 | 69121 | 21287 | 29861982 |
Application site hypersensitivity | 12.22 | 10.12 | 6 | 69203 | 125 | 29883144 |
Tension headache | 12.19 | 10.12 | 15 | 69194 | 1278 | 29881991 |
Chronic obstructive pulmonary disease | 12.12 | 10.12 | 60 | 69149 | 46066 | 29837203 |
Mobility decreased | 12.09 | 10.12 | 102 | 69107 | 25897 | 29857372 |
Lipoma | 12.08 | 10.12 | 16 | 69193 | 1467 | 29881802 |
Abdominal lymphadenopathy | 12.08 | 10.12 | 10 | 69199 | 529 | 29882740 |
Hyperkalaemia | 12.06 | 10.12 | 217 | 68992 | 65793 | 29817476 |
Exposure to communicable disease | 12.05 | 10.12 | 6 | 69203 | 129 | 29883140 |
Saccadic eye movement | 11.97 | 10.12 | 6 | 69203 | 131 | 29883138 |
Metastases to bone | 11.86 | 10.12 | 49 | 69160 | 9609 | 29873660 |
Pulmonary hypertension | 11.81 | 10.12 | 16 | 69193 | 19020 | 29864249 |
Gastric disorder | 11.80 | 10.12 | 52 | 69157 | 10491 | 29872778 |
Slow speech | 11.79 | 10.12 | 13 | 69196 | 985 | 29882284 |
Drug hypersensitivity | 11.74 | 10.12 | 223 | 68986 | 68296 | 29814973 |
Corneal transplant | 11.69 | 10.12 | 4 | 69205 | 31 | 29883238 |
Postictal paralysis | 11.69 | 10.12 | 6 | 69203 | 138 | 29883131 |
Skin lesion | 11.68 | 10.12 | 78 | 69131 | 18416 | 29864853 |
Stevens-Johnson syndrome | 11.67 | 10.12 | 75 | 69134 | 17481 | 29865788 |
Intestinal transit time decreased | 11.62 | 10.12 | 3 | 69206 | 7 | 29883262 |
Skin graft | 11.59 | 10.12 | 10 | 69199 | 560 | 29882709 |
Tongue oedema | 11.51 | 10.12 | 22 | 69187 | 2758 | 29880511 |
Laboratory test abnormal | 11.50 | 10.12 | 14 | 69195 | 17428 | 29865841 |
Metastases to heart | 11.49 | 10.12 | 6 | 69203 | 143 | 29883126 |
Metastases to peritoneum | 11.48 | 10.12 | 16 | 69193 | 1541 | 29881728 |
Pyomyositis | 11.46 | 10.12 | 6 | 69203 | 144 | 29883125 |
Small intestine ulcer | 11.45 | 10.12 | 9 | 69200 | 442 | 29882827 |
Small intestine carcinoma | 11.38 | 10.12 | 9 | 69200 | 446 | 29882823 |
Bicytopenia | 11.37 | 10.12 | 17 | 69192 | 1745 | 29881524 |
Osteoarthritis | 11.35 | 10.12 | 77 | 69132 | 18272 | 29864997 |
Oral herpes | 11.33 | 10.12 | 29 | 69180 | 4426 | 29878843 |
Blood pressure decreased | 11.32 | 10.12 | 162 | 69047 | 46913 | 29836356 |
Prurigo | 11.31 | 10.12 | 11 | 69198 | 719 | 29882550 |
Face oedema | 11.27 | 10.12 | 54 | 69155 | 11280 | 29871989 |
Diabetes mellitus | 11.27 | 10.12 | 54 | 69155 | 41811 | 29841458 |
Ileal perforation | 11.23 | 10.12 | 11 | 69198 | 726 | 29882543 |
Tenderness | 11.22 | 10.12 | 34 | 69175 | 5721 | 29877548 |
Ocular hyperaemia | 11.20 | 10.12 | 46 | 69163 | 8997 | 29874272 |
Gouty arthritis | 11.20 | 10.12 | 13 | 69196 | 1042 | 29882227 |
Ventricular tachycardia | 11.18 | 10.12 | 24 | 69185 | 23838 | 29859431 |
Delirium | 11.17 | 10.12 | 52 | 69157 | 40579 | 29842690 |
Intervertebral disc degeneration | 11.17 | 10.12 | 32 | 69177 | 5219 | 29878050 |
Scrotal ulcer | 11.12 | 10.12 | 8 | 69201 | 343 | 29882926 |
Hypoproteinaemia | 10.98 | 10.12 | 17 | 69192 | 1799 | 29881470 |
Pneumonitis | 10.98 | 10.12 | 30 | 69179 | 27424 | 29855845 |
Hypermetropia | 10.96 | 10.12 | 7 | 69202 | 246 | 29883023 |
Cognitive disorder | 10.96 | 10.12 | 24 | 69185 | 23666 | 29859603 |
Visual impairment | 10.93 | 10.12 | 113 | 69096 | 30325 | 29852944 |
Platelet count decreased | 10.88 | 10.12 | 176 | 69033 | 105953 | 29777316 |
Duodenal ulcer repair | 10.84 | 10.12 | 3 | 69206 | 10 | 29883259 |
Lip swelling | 10.77 | 10.12 | 58 | 69151 | 12686 | 29870583 |
Coronary artery disease | 10.72 | 10.12 | 69 | 69140 | 49643 | 29833626 |
Steroid diabetes | 10.72 | 10.12 | 14 | 69195 | 1267 | 29882002 |
Obstruction gastric | 10.71 | 10.12 | 12 | 69197 | 926 | 29882343 |
Intestinal angioedema | 10.69 | 10.12 | 6 | 69203 | 166 | 29883103 |
Stomatitis | 10.68 | 10.12 | 47 | 69162 | 37232 | 29846037 |
Eye swelling | 10.63 | 10.12 | 45 | 69164 | 8919 | 29874350 |
Pseudoporphyria | 10.60 | 10.12 | 7 | 69202 | 261 | 29883008 |
Helicobacter test positive | 10.57 | 10.12 | 9 | 69200 | 495 | 29882774 |
Application site dermatitis | 10.53 | 10.12 | 4 | 69205 | 43 | 29883226 |
Cytopenia | 10.53 | 10.12 | 3 | 69206 | 8253 | 29875016 |
Hepatitis C | 10.53 | 10.12 | 9 | 69200 | 13196 | 29870073 |
Orthostatic hypotension | 10.52 | 10.12 | 25 | 69184 | 23954 | 29859315 |
Drug resistance | 10.51 | 10.12 | 19 | 69190 | 20114 | 29863155 |
Renal infarct | 10.49 | 10.12 | 13 | 69196 | 1116 | 29882153 |
Product quality issue | 10.46 | 10.12 | 17 | 69192 | 18757 | 29864512 |
Exostosis | 10.40 | 10.12 | 24 | 69185 | 3431 | 29879838 |
Nail bed inflammation | 10.31 | 10.12 | 6 | 69203 | 178 | 29883091 |
Schizophrenia | 10.29 | 10.12 | 4 | 69205 | 9044 | 29874225 |
Encephalopathy | 10.23 | 10.12 | 39 | 69170 | 32166 | 29851103 |
Febrile bone marrow aplasia | 10.22 | 10.12 | 3 | 69206 | 8094 | 29875175 |
Bone marrow failure | 10.16 | 10.12 | 35 | 69174 | 29750 | 29853519 |
Source | Code | Description |
---|---|---|
ATC | D11AX18 | DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals |
ATC | M01AB05 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Acetic acid derivatives and related substances |
ATC | M02AA15 | MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use |
ATC | S01BC03 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Antiinflammatory agents, non-steroids |
ATC | M01AB55 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Acetic acid derivatives and related substances |
ATC | S01CC01 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Antiinflammatory agents, non-steroids and antiinfectives in combination |
FDA CS | M0001335 | Anti-Inflammatory Agents, Non-Steroidal |
FDA MoA | N0000000160 | Cyclooxygenase Inhibitors |
FDA PE | N0000008836 | Decreased Prostaglandin Production |
FDA EPC | N0000175722 | Nonsteroidal Anti-inflammatory Drug |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
MeSH PA | D016861 | Cyclooxygenase Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory drugs |
CHEBI has role | CHEBI:35493 | anti-pyretic |
CHEBI has role | CHEBI:35544 | cyclooxygenase inhibitors |
CHEBI has role | CHEBI:35703 | xenobiotic |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Ankylosing spondylitis | indication | 9631008 | DOID:7147 |
Pain | indication | 22253000 | |
Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
Actinic keratosis | indication | 201101007 | DOID:8866 |
Dysmenorrhea | indication | 266599000 | |
Osteoarthritis | indication | 396275006 | |
Rheumatoid Arthritis in Patient at High Ulcer Risk | indication | ||
Sprains and Strains | indication | ||
Postoperative Ocular Pain | indication | ||
Post-Op Ocular Inflammation | indication | ||
Post-Op Photophobia | indication | ||
Osteoarthrosis of the Knee | indication | ||
Osteoarthritis in Patients at High Ulcer Risk | indication | ||
Renal colic | off-label use | 7093002 | |
Tendinitis | off-label use | 34840004 | DOID:971 |
Bursitis | off-label use | 84017003 | DOID:2965 |
Cystoid macular edema | off-label use | 193387007 | DOID:4447 |
Prevention of Ocular Surgery-Induced Miosis | off-label use | ||
Keratitis | contraindication | 5888003 | DOID:4677 |
Alcoholism | contraindication | 7200002 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Asthenia | contraindication | 13791008 | |
Infection of skin AND/OR subcutaneous tissue | contraindication | 19824006 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
Dehydration | contraindication | 34095006 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Body fluid retention | contraindication | 43498006 | |
Skin ulcer | contraindication | 46742003 | |
Chronic heart failure | contraindication | 48447003 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Corneal erosion | contraindication | 50792001 | |
Duodenal ulcer disease | contraindication | 51868009 | DOID:1724 |
Gastrointestinal perforation | contraindication | 51875005 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Perforation of cornea | contraindication | 74895004 | |
Corneal ulcer | contraindication | 91514001 | DOID:8463 |
Corneal degeneration | contraindication | 111521006 | DOID:1237 |
Open wound | contraindication | 125643001 | |
Liver function tests abnormal | contraindication | 166603001 | |
Asthma | contraindication | 195967001 | DOID:2841 |
Deliveries by cesarean | contraindication | 200144004 | |
Cerebrovascular accident | contraindication | 230690007 | |
Coronary artery bypass graft | contraindication | 232717009 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Drug-induced hepatitis | contraindication | 235876009 | |
Edema | contraindication | 267038008 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thromboembolic disorder | contraindication | 371039008 | |
Cardiovascular event risk | contraindication | 395112001 | |
Smokes tobacco daily | contraindication | 449868002 | |
Uterine Rupture in Pregnancy | contraindication | ||
Bloody Vomit | contraindication | ||
Gynecological Surgery | contraindication | ||
Corneal Infiltrates | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.22 | acidic |
pKa2 | 0.55 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
1.3% | LICART | IBSA INST BIO | N206976 | Dec. 19, 2018 | RX | SYSTEM | TOPICAL | Dec. 19, 2021 | NEW PRODUCT |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 7.70 | WOMBAT-PK | CHEMBL | |||
Prostaglandin G/H synthase 1 | Enzyme | INHIBITOR | IC50 | 7.52 | WOMBAT-PK | CHEMBL | |||
UDP-glucuronosyltransferase 1-10 | Enzyme | Ki | 4.55 | CHEMBL | |||||
Interleukin-8 | Cytokine | IC50 | 8.10 | CHEMBL | |||||
UDP-glucuronosyltransferase 1-6 | Enzyme | Ki | 4.64 | CHEMBL | |||||
UDP-glucuronosyltransferase 1-7 | Enzyme | Ki | 4.72 | CHEMBL | |||||
UDP-glucuronosyltransferase 1-9 | Enzyme | Ki | 4.96 | CHEMBL | |||||
C-X-C chemokine receptor type 1 | GPCR | IC50 | 7.92 | CHEMBL | |||||
UDP-glucuronosyltransferase 1-1 | Enzyme | Ki | 4.28 | CHEMBL | |||||
Acid-sensing ion channel 3 | Ion channel | BLOCKER | IC50 | 4 | IUPHAR | ||||
Aldo-keto reductase family 1 member B10 | Enzyme | IC50 | 5.72 | CHEMBL | |||||
Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | ANTAGONIST | Ki | 6.20 | IUPHAR | ||||
Transthyretin | Secreted | Kd | 6 | CHEMBL | |||||
Aldo-keto reductase family 1 member C3 | Enzyme | IC50 | 5.59 | CHEMBL | |||||
Prostaglandin G/H synthase 2 | Enzyme | IC50 | 7.66 | CHEMBL | |||||
Fatty acid-binding protein, liver | Unclassified | Ki | 5.49 | CHEMBL | |||||
Prostaglandin G/H synthase 1 | Enzyme | IC50 | 8.52 | CHEMBL | |||||
Prostaglandin G/H synthase 2 | Enzyme | IC50 | 7.22 | CHEMBL | |||||
Prostaglandin G/H synthase 1 | Enzyme | IC50 | 7.17 | CHEMBL |
ID | Source |
---|---|
4019714 | VUID |
N0000147806 | NUI |
D00903 | KEGG_DRUG |
88170-10-9 | SECONDARY_CAS_RN |
4019378 | VANDF |
4019714 | VANDF |
4020829 | VANDF |
4027248 | VANDF |
C0012091 | UMLSCUI |
CHEBI:47381 | CHEBI |
DIF | PDB_CHEM_ID |
CHEMBL139 | ChEMBL_ID |
CHEMBL1201180 | ChEMBL_ID |
CHEMBL1200804 | ChEMBL_ID |
CHEMBL1034 | ChEMBL_ID |
DB00586 | DRUGBANK_ID |
D004008 | MESH_DESCRIPTOR_UI |
C000614065 | MESH_SUPPLEMENTAL_RECORD_UI |
C064142 | MESH_SUPPLEMENTAL_RECORD_UI |
3033 | PUBCHEM_CID |
2714 | IUPHAR_LIGAND_ID |
3270 | INN_ID |
144O8QL0L1 | UNII |
203214 | RXNORM |
11838 | MMSL |
23373 | MMSL |
3184 | MMSL |
340620 | MMSL |
37364 | MMSL |
4582 | MMSL |
4583 | MMSL |
4584 | MMSL |
d00848 | MMSL |
002391 | NDDF |
004409 | NDDF |
004410 | NDDF |
005170 | NDDF |
006237 | NDDF |
108515008 | SNOMEDCT_US |
363598004 | SNOMEDCT_US |
425650004 | SNOMEDCT_US |
426714006 | SNOMEDCT_US |
62039007 | SNOMEDCT_US |
7034005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
ARTHROTEC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0025-1411 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 30 sections |
ARTHROTEC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0025-1421 | TABLET, FILM COATED | 75 mg | ORAL | NDA | 30 sections |
VoltarenArthritis Pain | HUMAN OTC DRUG LABEL | 1 | 0067-8152 | GEL | 10 mg | TOPICAL | NDA | 18 sections |
VOLTAREN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0478 | SOLUTION | 1 mg | OPHTHALMIC | NDA | 16 sections |
Diclofenac Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0948 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 14 sections |
diclofenac epolamine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3225 | PATCH | 0.01 g | TOPICAL | NDA authorized generic | 30 sections |
diclofenac epolamine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3727 | SYSTEM | 0.01 g | TOPICAL | NDA AUTHORIZED GENERIC | 31 sections |
good sense arthritis pain | HUMAN OTC DRUG LABEL | 1 | 0113-1189 | GEL | 10 mg | TOPICAL | ANDA | 17 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1483 | GEL | 30 mg | TOPICAL | ANDA | 15 sections |
DICLOFENULLC SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0803 | GEL | 30 mg | TOPICAL | NDA authorized generic | 27 sections |
DICLOFENULLC SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0844 | GEL | 30 mg | TOPICAL | NDA authorized generic | 27 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2550 | TABLET, DELAYED RELEASE | 50 mg | ORAL | ANDA | 26 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2551 | TABLET, DELAYED RELEASE | 75 mg | ORAL | ANDA | 26 sections |
Aleve Arthritis Pain Gel | HUMAN OTC DRUG LABEL | 1 | 0280-0039 | GEL | 1 mg | TOPICAL | ANDA | 17 sections |
Diclofenac sodium | HUMAN OTC DRUG LABEL | 1 | 0363-1210 | GEL | 10 mg | TOPICAL | ANDA | 17 sections |
diclofenac sodium | HUMAN OTC DRUG LABEL | 1 | 0363-1871 | GEL | 10 mg | TOPICAL | ANDA | 17 sections |
Diclofenac Sodium Topical Gel 1% | Human OTC Drug Label | 1 | 0363-7065 | GEL | 10 mg | TOPICAL | ANDA | 15 sections |
Diclofenac Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2474 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 26 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-8750 | GEL | 10 mg | TOPICAL | ANDA | 28 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0472-1783 | GEL | 30 mg | TOPICAL | ANDA | 25 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2170 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 13 sections |
Diclofenac sodium | HUMAN OTC DRUG LABEL | 1 | 0536-1294 | GEL | 10 mg | TOPICAL | ANDA | 16 sections |
Diclofenac Sodium and Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0591-0397 | TABLET, DELAYED RELEASE | 50 mg | ORAL | ANDA | 28 sections |
Diclofenac Sodium and Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0591-0398 | TABLET, DELAYED RELEASE | 75 mg | ORAL | ANDA | 28 sections |
Solaraze | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10337-803 | GEL | 30 mg | TOPICAL | NDA | 27 sections |
Solaraze | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10337-844 | GEL | 30 mg | TOPICAL | NDA | 26 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-114 | TABLET, DELAYED RELEASE | 50 mg | ORAL | ANDA | 24 sections |
Diclofenac SodiumDelayed Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-188 | TABLET, DELAYED RELEASE | 50 mg | ORAL | ANDA | 28 sections |
Diclofenac SodiumDelayed Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-189 | TABLET, DELAYED RELEASE | 75 mg | ORAL | ANDA | 28 sections |
Diclofenac Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-921 | TABLET, DELAYED RELEASE | 75 mg | ORAL | ANDA | 24 sections |