esflurbiprofen Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 5060 51543-39-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • loqoa
  • esflurbiprofen
  • TT-063
  • Molecular weight: 244.27
  • Formula: C15H13FO2
  • CLOGP: 3.75
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -3.99
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 28, 2015 PMDA Taisho Pharmaceutical Co., Ltd.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Osteoarthritis indication 396275006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.2 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme IC50 6.04 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 7.52 CHEMBL

External reference:

IDSource
D10254 KEGG_DRUG
CHEMBL435298 ChEMBL_ID
J5ZZK9P7MX UNII
5776 INN_ID
CHEBI:42446 CHEBI
72099 PUBCHEM_CID
9420 IUPHAR_LIGAND_ID

Pharmaceutical products:

None