esomeprazole ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiulcer, benzimidazole derivatives 1055 119141-88-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • esomeprazole magnesium dihydrate
  • esomeprazole
  • (S)-Esomeprazole
  • (S)-Omeprazole
  • (-)-Omeprazole
  • esomeprazole magnesium
  • esomeprazole sodium
  • nexium control
  • esomeprazole magnesium hydrate
  • esomeprazole strontium
The S-isomer of omeprazole.
  • Molecular weight: 345.42
  • Formula: C17H19N3O3S
  • CLOGP: 2.56
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 77.10
  • ALOGS: -2.98
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O
30 mg P
0.50 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 5.79 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 53 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.85 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.03 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.83 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 2001 FDA ASTRAZENECA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Chronic kidney disease 870.21 9.36 965 240297 44433 63203327
Pemphigus 615.29 9.36 18 241244 183708 63064052
Drug ineffective 499.80 9.36 2164 239098 1042601 62205159
Glossodynia 497.48 9.36 51 241211 178825 63068935
Maternal exposure during pregnancy 438.17 9.36 145 241117 219917 63027843
Hand deformity 429.36 9.36 51 241211 159406 63088354
Systemic lupus erythematosus 427.78 9.36 131 241131 208787 63038973
Synovitis 383.02 9.36 117 241145 186801 63060959
Anti-cyclic citrullinated peptide antibody positive 379.67 9.36 14 241248 116198 63131562
Wound 361.13 9.36 88 241174 163175 63084585
Renal injury 329.32 9.36 279 240983 9160 63238600
Contraindicated product administered 308.62 9.36 226 241036 217422 63030338
Alopecia 308.19 9.36 505 240757 337031 62910729
Acute kidney injury 304.37 9.36 1875 239387 261540 62986220
Duodenal ulcer perforation 290.16 9.36 9 241253 87200 63160560
End stage renal disease 278.02 9.36 219 241043 6474 63241286
Arthropathy 275.94 9.36 291 240971 234501 63013259
Completed suicide 259.83 9.36 114 241148 145559 63102201
Pericarditis 254.31 9.36 91 241171 131488 63116272
Off label use 247.45 9.36 1527 239735 672935 62574825
Helicobacter infection 236.95 9.36 35 241227 92750 63155010
Discomfort 221.76 9.36 186 241076 167188 63080572
Drug intolerance 211.79 9.36 544 240718 308117 62939643
Folliculitis 200.78 9.36 18 241244 70299 63177461
Rheumatoid factor positive 199.74 9.36 39 241223 84367 63163393
Infusion related reaction 194.81 9.36 400 240862 245121 63002639
Treatment failure 194.64 9.36 284 240978 198759 63049001
Muscle injury 194.17 9.36 14 241248 65331 63182429
Carotid artery thrombosis 193.87 9.36 125 241137 2669 63245091
Hepatocellular injury 193.52 9.36 362 240900 27019 63220741
Neurologic neglect syndrome 191.94 9.36 123 241139 2598 63245162
Exposure during pregnancy 186.92 9.36 189 241073 155358 63092402
Joint swelling 186.72 9.36 630 240632 327036 62920724
Swelling 186.07 9.36 489 240773 274889 62972871
Hepatic enzyme increased 186.04 9.36 301 240961 202027 63045733
Cholestasis 185.83 9.36 371 240891 29063 63218697
Adjustment disorder 176.90 9.36 124 241138 3054 63244706
Sensitisation 174.38 9.36 126 241136 3260 63244500
Interstitial lung disease 165.51 9.36 565 240697 61343 63186417
Product use issue 161.91 9.36 375 240887 220145 63027615
Personality disorder 157.58 9.36 149 241113 5662 63242098
Cholecystitis chronic 154.81 9.36 194 241068 10167 63237593
Polycystic ovaries 153.59 9.36 131 241131 4340 63243420
Therapeutic product effect decreased 151.28 9.36 317 240945 192870 63054890
Toxicity to various agents 140.33 9.36 476 240786 246774 63000986
Hyponatraemia 139.45 9.36 813 240449 111087 63136673
Gastrooesophageal reflux disease 137.30 9.36 722 240540 94917 63152843
Renal failure 137.16 9.36 840 240422 116812 63130948
Ejection fraction 136.54 9.36 95 241167 2311 63245449
Tubulointerstitial nephritis 135.52 9.36 259 241003 19644 63228116
Hemiplegia 135.23 9.36 172 241090 9151 63238609
Abdominal discomfort 125.39 9.36 711 240551 320174 62927586
Product use in unapproved indication 122.39 9.36 316 240946 178764 63068996
Fatigue 121.72 9.36 2515 238747 885513 62362247
Blister 121.26 9.36 191 241071 129623 63118137
Psoriatic arthropathy 118.36 9.36 104 241158 91416 63156344
Dysphagia 117.84 9.36 655 240607 87930 63159830
Death 117.21 9.36 887 240375 373494 62874266
Coordination abnormal 115.18 9.36 196 241066 13577 63234183
Biliary dyskinesia 112.71 9.36 89 241173 2640 63245120
Rhinitis allergic 104.90 9.36 172 241090 11555 63236205
Sleep disorder due to general medical condition, insomnia type 101.03 9.36 36 241226 52181 63195579
Hypertensive nephropathy 99.72 9.36 49 241213 603 63247157
C-reactive protein abnormal 97.73 9.36 27 241235 46069 63201691
Irritable bowel syndrome 96.84 9.36 102 241160 82310 63165450
Affect lability 94.98 9.36 160 241102 10991 63236769
Motor dysfunction 93.79 9.36 156 241106 10605 63237155
Peripheral swelling 91.97 9.36 612 240650 265330 62982430
Inappropriate antidiuretic hormone secretion 88.28 9.36 187 241075 15275 63232485
Sleep apnoea syndrome 86.89 9.36 276 240986 28857 63218903
Lower respiratory tract infection 83.96 9.36 242 241020 132065 63115695
Rash maculo-papular 83.39 9.36 289 240973 31607 63216153
Agranulocytosis 82.30 9.36 246 241016 24888 63222872
Mobility decreased 81.82 9.36 215 241047 120944 63126816
Systemic lupus erythematosus rash 81.51 9.36 68 241194 2184 63245576
Ill-defined disorder 81.47 9.36 115 241147 81640 63166120
Condition aggravated 80.23 9.36 1062 240200 401155 62846605
Eosinophilia 79.56 9.36 228 241034 22528 63225232
Sensory loss 79.48 9.36 141 241121 10097 63237663
Abdominal pain upper 77.72 9.36 1158 240104 205286 63042474
Knee arthroplasty 77.10 9.36 56 241206 54150 63193610
Intentional product use issue 76.79 9.36 240 241022 127652 63120108
Toxic skin eruption 74.92 9.36 157 241105 12728 63235032
Hypersensitivity 74.72 9.36 731 240531 291954 62955806
Device expulsion 73.02 9.36 21 241241 34901 63212859
Nephrectomy 72.87 9.36 54 241208 1454 63246306
Hypomagnesaemia 70.50 9.36 255 241007 28482 63219278
Hemiparesis 68.00 9.36 219 241043 23063 63224697
Hypocalcaemia 65.16 9.36 266 240996 31447 63216313
Gastritis 64.48 9.36 297 240965 37006 63210754
Hip arthroplasty 64.22 9.36 52 241210 47594 63200166
Anxiety 64.02 9.36 1172 240090 216369 63031391
Loss of employment 63.65 9.36 59 241203 2185 63245575
Drug reaction with eosinophilia and systemic symptoms 63.45 9.36 276 240986 33560 63214200
Bronchial neoplasm 63.11 9.36 33 241229 467 63247293
Hiatus hernia 62.96 9.36 203 241059 21391 63226369
Carpal tunnel syndrome 62.80 9.36 198 241064 20619 63227141
Epigastric discomfort 62.76 9.36 101 241161 6679 63241081
Nephropathy 62.20 9.36 97 241165 6244 63241516
Pain 62.16 9.36 2247 239015 738381 62509379
Cardiospasm 61.71 9.36 54 241208 1853 63245907
Palmoplantar keratoderma 61.29 9.36 55 241207 1952 63245808
Rash 61.02 9.36 1644 239618 559227 62688533
Blood test abnormal 60.98 9.36 163 241099 15466 63232294
Hypothyroidism 59.88 9.36 320 240942 42312 63205448
Impaired healing 59.06 9.36 196 241066 102346 63145414
Pruritus genital 58.88 9.36 61 241201 2593 63245167
Renal disorder 58.83 9.36 265 240997 32709 63215051
Gastric polyps 57.77 9.36 68 241194 3337 63244423
Aphasia 57.23 9.36 263 240999 32737 63215023
Nasopharyngitis 56.78 9.36 655 240607 253602 62994158
Pleural fibrosis 56.70 9.36 68 241194 3404 63244356
Ejection fraction abnormal 56.67 9.36 50 241212 1735 63246025
Pregnancy 56.49 9.36 35 241227 36801 63210959
Live birth 56.25 9.36 14 241248 25616 63222144
Eating disorder 54.75 9.36 178 241084 18838 63228922
Acute generalised exanthematous pustulosis 54.09 9.36 126 241136 10973 63236787
Presbyacusis 53.30 9.36 60 241202 2805 63244955
Sleep disorder due to a general medical condition 52.58 9.36 132 241130 12056 63235704
Hepatic cytolysis 51.58 9.36 152 241110 15255 63232505
Gallbladder disorder 50.36 9.36 172 241090 18670 63229090
Nasal turbinate hypertrophy 50.16 9.36 33 241229 730 63247030
Sleep terror 49.64 9.36 56 241206 2624 63245136
Stomatitis 49.54 9.36 316 240946 138409 63109351
Gallbladder injury 49.51 9.36 42 241220 1381 63246379
Blood magnesium increased 48.80 9.36 59 241203 2979 63244781
Arterial occlusive disease 48.78 9.36 84 241178 5874 63241886
Diabetic nephropathy 48.72 9.36 42 241220 1412 63246348
Nephrogenic anaemia 48.52 9.36 50 241212 2112 63245648
Rebound acid hypersecretion 48.10 9.36 24 241238 306 63247454
Pleural thickening 47.97 9.36 57 241205 2826 63244934
Abortion spontaneous 47.39 9.36 66 241196 47129 63200631
Bronchial haemorrhage 47.39 9.36 29 241233 563 63247197
Therapy non-responder 47.28 9.36 140 241122 75761 63171999
Impaired work ability 47.13 9.36 160 241102 17315 63230445
Angioedema 47.02 9.36 328 240934 47637 63200123
Palpitations 46.95 9.36 644 240618 112126 63135634
Bronchial disorder 46.79 9.36 39 241223 1251 63246509
Tension headache 46.30 9.36 76 241186 5110 63242650
Premature delivery 46.12 9.36 29 241233 30252 63217508
Tenosynovitis stenosans 45.56 9.36 60 241202 3304 63244456
Angina pectoris 45.16 9.36 230 241032 29848 63217912
Infection 44.91 9.36 607 240655 228566 63019194
General physical health deterioration 43.34 9.36 523 240739 200879 63046881
Atrial tachycardia 43.18 9.36 66 241196 4174 63243586
Deafness neurosensory 43.14 9.36 71 241191 4784 63242976
Rheumatoid nodule 42.74 9.36 153 241109 17002 63230758
Musculoskeletal stiffness 42.21 9.36 473 240789 184145 63063615
Carotid artery occlusion 42.19 9.36 69 241193 4625 63243135
Pancreatitis 42.11 9.36 325 240937 48730 63199030
Nephritic syndrome 41.90 9.36 22 241240 314 63247446
Osteosclerosis 41.70 9.36 62 241200 3826 63243934
Pancreatitis acute 41.67 9.36 209 241053 26957 63220803
Drug abuse 41.48 9.36 139 241123 72379 63175381
Gastric disorder 41.12 9.36 263 240999 37106 63210654
Muscular weakness 40.93 9.36 673 240589 121680 63126080
Prescription form tampering 40.45 9.36 26 241236 552 63247208
Fall 39.33 9.36 1845 239417 390489 62857271
Prescribed overdose 39.30 9.36 43 241219 34110 63213650
Immunisation 39.04 9.36 34 241228 1159 63246601
Dysarthria 38.36 9.36 286 240976 42425 63205335
Cross sensitivity reaction 38.06 9.36 44 241218 2118 63245642
Phlebitis 38.01 9.36 81 241181 6643 63241117
Liver injury 37.43 9.36 112 241150 60408 63187352
Cholecystitis 37.33 9.36 136 241126 15241 63232519
Transient ischaemic attack 36.91 9.36 258 241004 37495 63210265
Endometrial ablation 36.75 9.36 30 241232 934 63246826
Anaemia 36.38 9.36 1411 239851 292019 62955741
Drug resistance 36.27 9.36 21 241241 22912 63224848
Respiratory tract congestion 36.18 9.36 149 241113 17683 63230077
Abdominal pain 36.12 9.36 1410 239852 292046 62955714
Therapy interrupted 36.10 9.36 42 241220 32413 63215347
Cholelithiasis 36.04 9.36 288 240974 43637 63204123
Iron deficiency anaemia 36.00 9.36 161 241101 19808 63227952
Intentional overdose 35.38 9.36 153 241109 73999 63173761
Gamma-glutamyltransferase increased 35.31 9.36 236 241026 33795 63213965
Axonal neuropathy 35.22 9.36 30 241232 992 63246768
Red blood cell sedimentation rate abnormal 34.43 9.36 16 241246 19766 63227994
Dry eye 34.40 9.36 269 240993 40492 63207268
Injection site erythema 34.21 9.36 181 241081 82993 63164767
Electric shock 34.19 9.36 33 241229 1287 63246473
Adverse drug reaction 34.18 9.36 171 241091 79543 63168217
Type 2 diabetes mellitus 34.13 9.36 126 241136 63742 63184018
Post cholecystectomy syndrome 33.86 9.36 21 241241 418 63247342
Anal abscess 33.67 9.36 62 241200 4570 63243190
Hypokalaemia 33.62 9.36 568 240694 103236 63144524
Drug hypersensitivity 33.60 9.36 911 240351 309776 62937984
Drug interaction 33.59 9.36 1123 240139 228008 63019752
Rhabdomyolysis 32.76 9.36 282 240980 43669 63204091
Ulcer 32.69 9.36 190 241072 25917 63221843
Sinus congestion 32.59 9.36 146 241116 17977 63229783
Crepitations 32.53 9.36 85 241177 7955 63239805
Dermatitis bullous 32.45 9.36 88 241174 8420 63239340
Macular degeneration 32.35 9.36 27 241235 24349 63223411
Asthma 32.32 9.36 672 240590 126889 63120871
Pancreatic neuroendocrine tumour 31.69 9.36 20 241242 411 63247349
Muscle spasticity 31.57 9.36 165 241097 21629 63226131
Bone erosion 31.35 9.36 14 241248 17703 63230057
Synovial fluid analysis 30.82 9.36 42 241220 2391 63245369
Dehydration 30.55 9.36 869 240393 172485 63075275
Occupational asthma 30.52 9.36 14 241248 146 63247614
Urate nephropathy 30.30 9.36 13 241249 114 63247646
Chest pain 30.03 9.36 1052 240210 214907 63032853
Burning sensation 29.69 9.36 327 240935 54080 63193680
Malnutrition 29.61 9.36 126 241136 15172 63232588
Vascular purpura 29.30 9.36 32 241230 1446 63246314
Gastric antral vascular ectasia 29.29 9.36 22 241240 605 63247155
No adverse event 29.07 9.36 72 241190 41333 63206427
Cardiac disorder 28.93 9.36 308 240954 50508 63197252
Bone cyst 28.69 9.36 39 241223 2215 63245545
Cell death 28.65 9.36 42 241220 2559 63245201
Asthenia 28.63 9.36 1755 239507 381849 62865911
Cholestatic liver injury 28.54 9.36 42 241220 2568 63245192
Anosmia 28.24 9.36 73 241189 6787 63240973
Diplopia 27.98 9.36 170 241092 23558 63224202
Accidental exposure to product 27.84 9.36 38 241224 27367 63220393
Caesarean section 27.80 9.36 15 241247 17017 63230743
Rheumatoid arthritis 27.49 9.36 744 240518 253075 62994685
Kidney infection 27.30 9.36 166 241096 23010 63224750
Gangrene 27.13 9.36 67 241195 6056 63241704
Erythema dyschromicum perstans 27.11 9.36 10 241252 56 63247704
Myelosuppression 27.10 9.36 30 241232 23673 63224087
Disease progression 27.07 9.36 317 240945 122441 63125319
Scleritis 26.97 9.36 55 241207 4373 63243387
Muscle contractions involuntary 26.89 9.36 39 241223 2353 63245407
Contusion 26.70 9.36 405 240857 149639 63098121
Eosinophilic fasciitis 26.31 9.36 13 241249 162 63247598
Obesity 26.15 9.36 46 241216 29906 63217854
Lung disorder 26.08 9.36 356 240906 61905 63185855
Blood cholesterol increased 26.03 9.36 230 241032 93802 63153958
Face oedema 25.89 9.36 148 241114 20064 63227696
Nerve injury 25.89 9.36 90 241172 9856 63237904
Angina bullosa haemorrhagica 25.60 9.36 12 241250 132 63247628
Renal impairment 25.59 9.36 475 240787 87880 63159880
Nasal discharge discolouration 25.49 9.36 37 241225 2234 63245526
Autoimmune disorder 25.41 9.36 17 241245 17160 63230600
Subacute cutaneous lupus erythematosus 25.32 9.36 40 241222 2603 63245157
Cutaneous lupus erythematosus 24.56 9.36 40 241222 2672 63245088
Foetal exposure during pregnancy 24.52 9.36 53 241209 31909 63215851
Diverticulum 24.17 9.36 100 241162 11891 63235869
Adverse event 24.05 9.36 154 241108 67405 63180355
Drug eruption 24.01 9.36 189 241073 28505 63219255
Multi-organ disorder 23.69 9.36 29 241233 1483 63246277
Neutropenic sepsis 23.35 9.36 17 241245 16421 63231339
Nephritis allergic 23.34 9.36 13 241249 210 63247550
Oesophageal dilatation 23.15 9.36 16 241246 385 63247375
Liver function test increased 23.08 9.36 57 241205 32754 63215006
Hunger 22.93 9.36 58 241204 5321 63242439
Eczema 22.93 9.36 205 241057 32086 63215674
Gallbladder polyp 22.92 9.36 21 241241 766 63246994
Blood alkaline phosphatase increased 22.88 9.36 257 241005 42710 63205050
Haemoglobin decreased 22.84 9.36 719 240543 144766 63102994
Ventricular tachycardia 22.84 9.36 142 241120 19837 63227923
Arthralgia 22.76 9.36 1860 239402 567850 62679910
Poisoning 22.45 9.36 12 241250 13688 63234072
Muscle haemorrhage 22.42 9.36 42 241220 3137 63244623
Nausea 22.39 9.36 3633 237629 850838 62396922
Neurotoxicity 22.33 9.36 19 241243 16971 63230789
Supraventricular extrasystoles 22.25 9.36 52 241210 4537 63243223
Aspartate aminotransferase 21.91 9.36 16 241246 421 63247339
Bunion operation 21.77 9.36 26 241236 1296 63246464
Hepatic steatosis 21.65 9.36 185 241077 28584 63219176
Grip strength decreased 21.55 9.36 32 241230 22255 63225505
Hypergastrinaemia 21.50 9.36 10 241252 108 63247652
Schizophreniform disorder 21.48 9.36 9 241253 74 63247686
Cerebrovascular accident 21.44 9.36 550 240712 107474 63140286
Vitamin B12 deficiency 21.39 9.36 56 241206 5247 63242513
Mesenteric panniculitis 21.34 9.36 10 241252 110 63247650
Hallucination 21.18 9.36 309 240953 54508 63193252
Hypocapnia 21.17 9.36 15 241247 376 63247384
Blindness 21.04 9.36 148 241114 21551 63226209
Synovial cyst 21.03 9.36 87 241175 10346 63237414
Rhinalgia 20.86 9.36 28 241234 1571 63246189
Haematotoxicity 20.81 9.36 5 241257 9371 63238389
Intervertebral discitis 20.74 9.36 41 241221 3187 63244573
Febrile bone marrow aplasia 20.58 9.36 68 241194 7257 63240503
Dermatitis exfoliative generalised 20.54 9.36 45 241217 3762 63243998
Dislocation of vertebra 20.40 9.36 4 241258 8631 63239129
Medication error 20.28 9.36 116 241146 52168 63195592
Tooth infection 20.26 9.36 127 241135 17793 63229967
Vertigo 20.23 9.36 330 240932 59557 63188203
Eyelid oedema 20.04 9.36 86 241176 10393 63237367
Cholecystitis acute 20.01 9.36 73 241189 8187 63239573
Gallbladder hypofunction 19.99 9.36 17 241245 561 63247199
Product dose omission issue 19.95 9.36 709 240553 233604 63014156
Subarachnoid haemorrhage 19.91 9.36 107 241155 14176 63233584
Sedation 19.80 9.36 78 241184 38731 63209029
Lip oedema 19.62 9.36 45 241217 3879 63243881
Flatulence 19.59 9.36 210 241052 34492 63213268
Gastrointestinal motility disorder 19.58 9.36 53 241209 5066 63242694
Therapy partial responder 19.53 9.36 8 241254 10650 63237110
Nephrosclerosis 19.48 9.36 22 241240 1032 63246728
Bile duct stone 19.48 9.36 43 241219 3613 63244147
Facet joint syndrome 19.36 9.36 11 241251 12127 63235633
Vasculitis 19.32 9.36 127 241135 18082 63229678
Injection site pain 19.29 9.36 362 240900 129438 63118322
Cerebral haematoma 19.26 9.36 43 241219 3640 63244120
Granulocyte count increased 18.97 9.36 20 241242 868 63246892
Vulvovaginal burning sensation 18.95 9.36 31 241231 2078 63245682
International normalised ratio increased 18.85 9.36 264 240998 46161 63201599
Rash papular 18.83 9.36 113 241149 15589 63232171
Breast cancer stage II 18.73 9.36 5 241257 8731 63239029
Photophobia 18.72 9.36 123 241139 17512 63230248
Immunodeficiency 18.71 9.36 30 241232 20224 63227536
Dry mouth 18.68 9.36 407 240855 77456 63170304
X-ray abnormal 18.65 9.36 4 241258 8106 63239654
Rectosigmoid cancer 18.61 9.36 10 241252 150 63247610
Cyst 18.56 9.36 104 241158 13995 63233765
Weight increased 18.53 9.36 806 240456 259986 62987774
Gastrointestinal haemorrhage 18.43 9.36 421 240841 80755 63167005
Haematoma 18.41 9.36 208 241054 34612 63213148
Illness 18.41 9.36 110 241152 48949 63198811
Small cell carcinoma 18.26 9.36 10 241252 156 63247604
Injection site swelling 18.20 9.36 106 241156 47466 63200294
Sciatica 18.15 9.36 68 241194 34256 63213504
Mixed liver injury 18.09 9.36 49 241213 4686 63243074
Ingrowing nail 18.08 9.36 33 241229 2416 63245344
Acute hepatitis B 18.00 9.36 13 241249 336 63247424
Breath sounds abnormal 17.96 9.36 86 241176 10887 63236873
Pleuritic pain 17.82 9.36 69 241193 7960 63239800
Congenital osteodystrophy 17.70 9.36 6 241256 25 63247735
Pneumobilia 17.62 9.36 9 241253 121 63247639
Fear of injection 17.61 9.36 3 241259 7161 63240599
Allergy to chemicals 17.61 9.36 37 241225 3005 63244755
Blood immunoglobulin A increased 17.47 9.36 18 241244 760 63247000
Normal newborn 17.46 9.36 5 241257 8336 63239424
Salpingo-oophorectomy unilateral 17.34 9.36 19 241243 862 63246898
Throat irritation 17.32 9.36 219 241043 37428 63210332
Adenocarcinoma gastric 17.13 9.36 15 241247 515 63247245
Dysphonia 17.07 9.36 265 240997 47349 63200411
Glomerular filtration rate increased 17.04 9.36 19 241243 879 63246881
Cholecystectomy 16.98 9.36 83 241179 10594 63237166
Jaundice 16.98 9.36 178 241084 29073 63218687
Bradypnoea 16.97 9.36 40 241222 3510 63244250
Crohn's disease 16.95 9.36 49 241213 4864 63242896
Rhonchi 16.89 9.36 33 241229 2543 63245217
Hepatitis cholestatic 16.84 9.36 61 241201 6817 63240943
Anaemia macrocytic 16.60 9.36 39 241223 3415 63244345
IIIrd nerve paresis 16.58 9.36 9 241253 138 63247622
Arterial spasm 16.55 9.36 7 241255 59 63247701
Genital infection female 16.46 9.36 8 241254 96 63247664
Haemorrhoids 16.44 9.36 142 241120 22008 63225752
Rhinitis 16.42 9.36 86 241176 11280 63236480
Melaena 16.34 9.36 182 241080 30183 63217577
Injection site bruising 16.24 9.36 93 241169 41817 63205943
Muscle swelling 16.21 9.36 14 241248 472 63247288
Creatinine renal clearance decreased 16.18 9.36 23 241239 16285 63231475
Hepatotoxicity 16.14 9.36 79 241183 36962 63210798
Tetany 16.10 9.36 28 241234 1973 63245787
Herpes simplex test positive 16.05 9.36 11 241251 261 63247499
Myocardial infarction 16.02 9.36 495 240767 99398 63148362
Hepatitis B DNA increased 16.01 9.36 11 241251 262 63247498
Non-economic loss 16.01 9.36 5 241257 15 63247745
Device dependence 16.01 9.36 5 241257 15 63247745
Deformity 15.93 9.36 87 241175 11597 63236163
Angina unstable 15.77 9.36 61 241201 7034 63240726
Livedo reticularis 15.76 9.36 31 241231 2401 63245359
Pathological fracture 15.76 9.36 71 241191 8763 63238997
Oesophagitis ulcerative 15.73 9.36 15 241247 576 63247184
Escherichia pyelonephritis 15.68 9.36 13 241249 414 63247346
Chondrocalcinosis pyrophosphate 15.66 9.36 21 241241 1177 63246583
Hyperhidrosis 15.64 9.36 528 240734 107308 63140452
Renal cyst 15.62 9.36 79 241183 10223 63237537
Skin lesion 15.57 9.36 182 241080 30539 63217221
Tinnitus 15.45 9.36 205 241057 35423 63212337
Gastrointestinal disorder 15.44 9.36 380 240882 130859 63116901
Facial pain 15.32 9.36 80 241182 10481 63237279
Pancreatitis chronic 15.30 9.36 31 241231 2453 63245307
Disability 15.29 9.36 29 241233 18318 63229442
Diarrhoea 15.28 9.36 3010 238252 712356 62535404
Anaemia folate deficiency 15.25 9.36 10 241252 220 63247540
Blood chromogranin A increased 15.24 9.36 11 241251 284 63247476
Peripheral venous disease 15.18 9.36 22 241240 15455 63232305
Hyperparathyroidism secondary 15.17 9.36 23 241239 1444 63246316
Lip dry 15.17 9.36 22 241240 15448 63232312
Hyperchlorhydria 15.10 9.36 26 241236 1818 63245942
Blood creatine phosphokinase decreased 15.09 9.36 14 241248 519 63247241
Neutropenia 15.01 9.36 529 240733 174476 63073284
Purpura 15.00 9.36 84 241178 11301 63236459
Complication of device insertion 15 9.36 5 241257 7559 63240201
Injection site pruritus 14.97 9.36 105 241157 45011 63202749
Pre-eclampsia 14.97 9.36 8 241254 9125 63238635
Gait inability 14.89 9.36 129 241133 52830 63194930
Pulmonary embolism 14.88 9.36 563 240699 116121 63131639
Renal tubular disorder 14.81 9.36 32 241230 2650 63245110
Osteopenia 14.77 9.36 127 241135 19658 63228102
Dermatitis exfoliative 14.73 9.36 50 241212 5409 63242351
Deja vu 14.70 9.36 7 241255 80 63247680
Oesophageal polyp 14.66 9.36 4 241258 6 63247754
Renal tubular necrosis 14.58 9.36 86 241176 11792 63235968
Atelectasis 14.55 9.36 135 241127 21348 63226412
Sinus disorder 14.53 9.36 150 241112 24403 63223357
Purging 14.46 9.36 6 241256 48 63247712
Retinal artery occlusion 14.45 9.36 24 241238 1629 63246131
Cerebellar haematoma 14.45 9.36 12 241250 383 63247377
Emotional distress 14.41 9.36 188 241074 32361 63215399
Chest discomfort 14.36 9.36 532 240730 109437 63138323
Proteinuria 14.35 9.36 123 241139 19022 63228738
Oesophagitis 14.34 9.36 102 241160 14906 63232854
Keratoacanthoma 14.29 9.36 13 241249 470 63247290
Vitamin D deficiency 14.20 9.36 96 241166 13796 63233964
Device dislocation 14.20 9.36 50 241212 25655 63222105
Dysgeusia 14.18 9.36 253 241009 46457 63201303
Body temperature increased 14.16 9.36 83 241179 37109 63210651
Cough 14.14 9.36 1294 239968 291449 62956311
Premature labour 14.10 9.36 16 241246 12488 63235272
Antinuclear antibody positive 14.05 9.36 64 241198 7935 63239825
Uveal melanoma 13.94 9.36 4 241258 8 63247752
Blood potassium increased 13.92 9.36 118 241144 18191 63229569
Finger deformity 13.89 9.36 6 241256 7739 63240021
Neurosis 13.86 9.36 10 241252 258 63247502
Early satiety 13.85 9.36 18 241244 978 63246782
Calcium metabolism disorder 13.80 9.36 8 241254 140 63247620
Dialysis 13.78 9.36 77 241185 10350 63237410
Meningitis aseptic 13.75 9.36 45 241217 4778 63242982
Gastrointestinal tract mucosal pigmentation 13.65 9.36 14 241248 588 63247172
Musculoskeletal disorder 13.65 9.36 37 241225 20607 63227153
Deep vein thrombosis 13.64 9.36 416 240846 83384 63164376
Sneezing 13.63 9.36 117 241145 18101 63229659
Chronic kidney disease-mineral and bone disorder 13.58 9.36 7 241255 96 63247664
Genotype drug resistance test positive 13.49 9.36 12 241250 421 63247339
Maternal exposure before pregnancy 13.46 9.36 6 241256 7597 63240163
Lower limb fracture 13.46 9.36 47 241215 24174 63223586
Erosive oesophagitis 13.45 9.36 24 241238 1726 63246034
Female sterilisation 13.40 9.36 14 241248 601 63247159
Gastric ulcer 13.36 9.36 145 241117 23892 63223868
Hepatitis 13.34 9.36 219 241043 39569 63208191
Hypoplastic anaemia 13.33 9.36 4 241258 10 63247750
Tenosynovitis 13.32 9.36 94 241168 13701 63234059
Hyponatraemic seizure 13.25 9.36 12 241250 431 63247329
Erythema 13.24 9.36 805 240457 174946 63072814
Post-traumatic stress disorder 13.22 9.36 47 241215 5204 63242556
Hyperkalaemia 13.21 9.36 284 240978 53919 63193841
Antipsychotic drug level above therapeutic 13.20 9.36 18 241244 1025 63246735
Sputum increased 13.19 9.36 29 241233 2430 63245330
Teeth brittle 13.15 9.36 13 241249 522 63247238
Brucellosis 13.13 9.36 6 241256 62 63247698
Intestinal infarction 13.11 9.36 18 241244 1032 63246728
Prothrombin time ratio decreased 13.09 9.36 13 241249 525 63247235
Musculoskeletal chest pain 13.05 9.36 130 241132 20953 63226807
Hypofibrinogenaemia 13.04 9.36 19 241243 1151 63246609
Protein-losing gastroenteropathy 13.04 9.36 9 241253 216 63247544
Bladder sphincter atony 13.00 9.36 8 241254 157 63247603
Campylobacter colitis 13.00 9.36 5 241257 32 63247728
Skin haemorrhage 12.99 9.36 74 241188 10020 63237740
Pyelonephritis acute 12.96 9.36 43 241219 4598 63243162
Blood loss anaemia 12.93 9.36 68 241194 8933 63238827
Breast cancer stage I 12.90 9.36 5 241257 6884 63240876
Glossitis 12.90 9.36 33 241229 3049 63244711
Clinically isolated syndrome 12.87 9.36 5 241257 33 63247727
Thymus disorder 12.83 9.36 10 241252 291 63247469
Abortion induced 12.80 9.36 12 241250 10230 63237530
Congenital bowing of long bones 12.80 9.36 6 241256 66 63247694
Coeliac disease 12.74 9.36 18 241244 12779 63234981
Therapy cessation 12.67 9.36 66 241196 30391 63217369
Thrombocytopenia 12.66 9.36 699 240563 150458 63097302
Renal haemangioma 12.62 9.36 5 241257 35 63247725
Aspartate aminotransferase increased 12.58 9.36 440 240822 89837 63157923
Pulmonary congestion 12.58 9.36 111 241151 17307 63230453
Laboratory test abnormal 12.55 9.36 56 241206 26856 63220904
Joint range of motion decreased 12.54 9.36 72 241190 32356 63215404
Malabsorption 12.53 9.36 39 241223 4033 63243727
Rheumatoid factor increased 12.51 9.36 24 241238 1825 63245935
Lordosis 12.48 9.36 10 241252 303 63247457
Sudden death 12.41 9.36 75 241187 10374 63237386
Unintended pregnancy 12.40 9.36 4 241258 6175 63241585
Tongue oedema 12.37 9.36 42 241220 4544 63243216
Hyperthermia 12.36 9.36 68 241194 9088 63238672
Exposure to toxic agent 12.36 9.36 3 241259 5584 63242176
Rash scarlatiniform 12.36 9.36 7 241255 117 63247643
Hyperphosphatasaemia 12.34 9.36 4 241258 14 63247746
Atrioventricular block complete 12.32 9.36 63 241199 8188 63239572
Hepatic function abnormal 12.29 9.36 204 241058 36938 63210822
Renal atrophy 12.27 9.36 21 241241 1461 63246299
Monoclonal gammopathy 12.26 9.36 14 241248 665 63247095
Small intestinal stenosis 12.26 9.36 13 241249 568 63247192
Unintentional medical device removal 12.20 9.36 4 241258 6111 63241649
Colitis ischaemic 12.17 9.36 76 241186 10632 63237128
Vitreous detachment 12.14 9.36 25 241237 2002 63245758
Cushingoid 12.12 9.36 64 241198 8421 63239339
Paranasal sinus inflammation 12.12 9.36 12 241250 483 63247277
Febrile neutropenia 12.09 9.36 350 240912 118099 63129661
Erythema multiforme 12.08 9.36 73 241189 10096 63237664
Aeromonas infection 12.06 9.36 6 241256 76 63247684
Seizure 12.05 9.36 398 240864 132236 63115524
Rectal cancer metastatic 12.00 9.36 9 241253 247 63247513
Poor personal hygiene 11.96 9.36 10 241252 322 63247438
Transplant rejection 11.94 9.36 14 241248 10766 63236994
Low turnover osteopathy 11.89 9.36 39 241223 4146 63243614
Gastrointestinal ischaemia 11.89 9.36 8 241254 184 63247576
Hypoosmolar state 11.89 9.36 8 241254 184 63247576
Crystal arthropathy 11.86 9.36 10 241252 326 63247434
Anaemia vitamin B12 deficiency 11.85 9.36 11 241251 408 63247352
Essential hypertension 11.79 9.36 44 241218 4989 63242771
Device difficult to use 11.77 9.36 19 241243 12777 63234983
Lipase increased 11.72 9.36 71 241191 9829 63237931
Sinus bradycardia 11.71 9.36 95 241167 14456 63233304
Hyperlipasaemia 11.70 9.36 14 241248 699 63247061
Rectal haemorrhage 11.67 9.36 256 241006 48774 63198986
Gastric adenoma 11.66 9.36 3 241259 3 63247757
Platelet adhesiveness decreased 11.66 9.36 3 241259 3 63247757
Disturbance in attention 11.65 9.36 207 241055 37982 63209778
Stent placement 11.59 9.36 36 241226 3719 63244041
Infusion site scar 11.55 9.36 12 241250 512 63247248
Infusion site thrombosis 11.53 9.36 7 241255 134 63247626
Lactic acidosis 11.49 9.36 207 241055 38080 63209680
Swollen tongue 11.47 9.36 191 241071 34609 63213151
Sinusitis fungal 11.46 9.36 23 241239 1808 63245952
Polyglandular autoimmune syndrome type II 11.45 9.36 5 241257 46 63247714
Vitamin B12 decreased 11.44 9.36 35 241227 3585 63244175
Faeces discoloured 11.39 9.36 114 241148 18395 63229365
Concussion 11.39 9.36 67 241195 9177 63238583
Gastrointestinal tract mucosal discolouration 11.38 9.36 4 241258 19 63247741
Burns second degree 11.38 9.36 24 241238 1954 63245806
Foetal death 11.38 9.36 15 241247 10965 63236795
Hypoparathyroidism secondary 11.35 9.36 5 241257 47 63247713
Eructation 11.33 9.36 62 241200 8271 63239489
Therapeutic response decreased 11.30 9.36 165 241097 61360 63186400
Tongue pruritus 11.28 9.36 12 241250 526 63247234
Dilatation atrial 11.27 9.36 24 241238 1967 63245793
Coronary artery occlusion 11.17 9.36 61 241201 8130 63239630
Night sweats 11.16 9.36 125 241137 48689 63199071
Purple glove syndrome 11.14 9.36 8 241254 205 63247555
Enterocolitis haemorrhagic 11.14 9.36 20 241242 1446 63246314
Epiglottic oedema 11.11 9.36 6 241256 91 63247669
Diverticulum oesophageal 11.08 9.36 7 241255 144 63247616
Eye irritation 11.06 9.36 130 241132 21841 63225919
Acute coronary syndrome 10.97 9.36 71 241191 10055 63237705
Vulval disorder 10.96 9.36 15 241247 857 63246903
Eye pain 10.86 9.36 185 241077 33669 63214091
Vulvovaginal pruritus 10.86 9.36 32 241230 3211 63244549
COVID-19 10.85 9.36 337 240925 112766 63134994
Purpura senile 10.83 9.36 12 241250 551 63247209
Wrong technique in product usage process 10.83 9.36 169 241093 62171 63185589
Renal hypertrophy 10.83 9.36 5 241257 53 63247707
Granuloma 10.80 9.36 47 241215 5714 63242046
Chronic cutaneous lupus erythematosus 10.80 9.36 10 241252 370 63247390
Type I hypersensitivity 10.79 9.36 30 241232 2912 63244848
Blood thyroid stimulating hormone increased 10.79 9.36 55 241207 7139 63240621
Eyelid haematoma 10.76 9.36 4 241258 23 63247737
Renal hypertension 10.75 9.36 7 241255 152 63247608
Gastric ulcer haemorrhage 10.75 9.36 42 241220 4866 63242894
Acute cutaneous lupus erythematosus 10.74 9.36 9 241253 291 63247469
Dyslipidaemia 10.72 9.36 56 241206 7337 63240423
Muscle enzyme increased 10.71 9.36 7 241255 153 63247607
Dermatosis 10.71 9.36 9 241253 292 63247468
Vitamin B12 increased 10.71 9.36 17 241245 1111 63246649
Affective disorder 10.67 9.36 49 241213 6097 63241663
Nikolsky's sign 10.66 9.36 6 241256 99 63247661
Iron deficiency 10.65 9.36 55 241207 7175 63240585
Hypoparathyroidism 10.62 9.36 13 241249 665 63247095
Placental calcification 10.61 9.36 4 241258 24 63247736
Therapeutic response shortened 10.61 9.36 18 241244 11870 63235890
Gingival pain 10.61 9.36 60 241202 8102 63239658
Oedema peripheral 10.60 9.36 847 240415 188664 63059096
Thrombocytopenic purpura 10.60 9.36 19 241243 1372 63246388
Tooth disorder 10.59 9.36 158 241104 27999 63219761
Blood magnesium decreased 10.53 9.36 86 241176 13112 63234648
Tachycardia paroxysmal 10.53 9.36 9 241253 299 63247461
Dystonia 10.53 9.36 23 241239 13796 63233964
Bronchopneumopathy 10.50 9.36 8 241254 225 63247535
Resorption bone increased 10.48 9.36 18 241244 1256 63246504
Cardiothoracic ratio increased 10.48 9.36 4 241258 25 63247735
Red blood cell target cells present 10.46 9.36 3 241259 6 63247754
Malignant neoplasm progression 10.43 9.36 235 241027 81886 63165874
Carnitine deficiency 10.40 9.36 7 241255 161 63247599
Septic shock 10.37 9.36 329 240933 66300 63181460
Catarrh 10.35 9.36 20 241242 1529 63246231
Blood gastrin increased 10.35 9.36 4 241258 26 63247734
Dysuria 10.33 9.36 183 241079 33555 63214205
Hepatobiliary scan abnormal 10.29 9.36 5 241257 60 63247700
Oedema mouth 10.27 9.36 26 241236 2387 63245373
Pulmonary arterial hypertension 10.24 9.36 131 241131 22446 63225314
Portal vein dilatation 10.22 9.36 4 241258 27 63247733
Blepharospasm 10.20 9.36 5 241257 5991 63241769
Cholangitis 10.15 9.36 45 241217 5516 63242244
Tri-iodothyronine free decreased 10.13 9.36 9 241253 315 63247445
Neoplasm progression 10.12 9.36 89 241173 36339 63211421
Bronchitis 10.12 9.36 576 240686 124359 63123401
Spinal osteoarthritis 10.11 9.36 100 241162 16086 63231674
Regurgitation 10.10 9.36 21 241241 1693 63246067
Neuroleptic malignant syndrome 10.09 9.36 19 241243 12037 63235723
Flank pain 10.07 9.36 101 241161 16309 63231451
Incorrect route of product administration 10.06 9.36 62 241200 27390 63220370
Renal infarct 10.06 9.36 19 241243 1428 63246332
Multiple sclerosis 10.06 9.36 139 241123 24233 63223527
Fracture nonunion 10.05 9.36 25 241237 2270 63245490
Actinic keratosis 10.00 9.36 27 241235 2577 63245183
Acute sinusitis 9.97 9.36 35 241227 3852 63243908
Vagus nerve disorder 9.97 9.36 6 241256 113 63247647
Language disorder 9.96 9.36 24 241238 2136 63245624
Atrophy 9.95 9.36 21 241241 1711 63246049
Renal lymphocele 9.93 9.36 5 241257 65 63247695
Alanine aminotransferase increased 9.93 9.36 486 240776 103284 63144476
Coma acidotic 9.92 9.36 6 241256 114 63247646
Vulvovaginal inflammation 9.90 9.36 14 241248 825 63246935
Mandibular mass 9.89 9.36 7 241255 175 63247585
Arterial fibrosis 9.86 9.36 3 241259 8 63247752
Heat stroke 9.79 9.36 14 241248 834 63246926
Extremity necrosis 9.78 9.36 20 241242 1593 63246167
Product storage error 9.74 9.36 27 241235 14929 63232831
Cardiac failure 9.72 9.36 423 240839 88719 63159041
Localised infection 9.69 9.36 71 241191 30139 63217621
Device malfunction 9.69 9.36 35 241227 17822 63229938
Fungal oesophagitis 9.66 9.36 13 241249 731 63247029
Gastric haemorrhage 9.65 9.36 49 241213 6349 63241411
Biliary colic 9.65 9.36 33 241229 3584 63244176
Atypical fracture 9.65 9.36 12 241250 624 63247136
Haemorrhage foetal 9.61 9.36 3 241259 9 63247751
Carotid artery stenosis 9.56 9.36 42 241220 5128 63242632
Lumbar spinal stenosis 9.55 9.36 40 241222 4782 63242978
Dental restoration failure 9.54 9.36 15 241247 972 63246788
Vascular encephalopathy 9.54 9.36 10 241252 431 63247329
Oesophageal irritation 9.52 9.36 6 241256 123 63247637
Renal tuberculosis 9.43 9.36 4 241258 34 63247726
Liver abscess 9.40 9.36 28 241234 2826 63244934
Complication associated with device 9.40 9.36 33 241229 16945 63230815
Peripheral artery thrombosis 9.38 9.36 22 241240 1924 63245836

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Chronic kidney disease 529.14 10.19 738 140340 40472 34775381
Toxicity to various agents 247.92 10.19 266 140812 200096 34615757
Drug ineffective 231.85 10.19 1004 140074 455747 34360106
Death 222.60 10.19 842 140236 397207 34418646
Drug abuse 211.84 10.19 68 141010 99028 34716825
End stage renal disease 192.33 10.19 207 140871 8654 34807199
Completed suicide 171.65 10.19 91 140987 98077 34717776
Acute kidney injury 168.47 10.19 1925 139153 303063 34512790
Off label use 154.27 10.19 1027 140051 418497 34397356
Cholestasis 145.23 10.19 330 140748 26618 34789235
Hepatocellular injury 137.93 10.19 288 140790 21923 34793930
Interstitial lung disease 137.57 10.19 575 140503 64707 34751146
Toxic skin eruption 134.35 10.19 196 140882 11189 34804664
Renal injury 132.50 10.19 193 140885 11002 34804851
Hypomagnesaemia 98.78 10.19 250 140828 21601 34794252
Cardiospasm 92.01 10.19 65 141013 1523 34814330
Eosinophilia 91.64 10.19 273 140805 25949 34789904
Treatment failure 80.53 10.19 44 141034 46653 34769200
Palmoplantar keratoderma 80.03 10.19 65 141013 1888 34813965
Agranulocytosis 79.48 10.19 244 140834 23577 34792276
Hypocalcaemia 74.80 10.19 242 140836 24047 34791806
Tension headache 71.22 10.19 74 141004 2968 34812885
Pruritus genital 71.20 10.19 64 141014 2140 34813713
Product use in unapproved indication 70.96 10.19 240 140838 117259 34698594
Nephrogenic anaemia 67.12 10.19 62 141016 2149 34813704
Tubulointerstitial nephritis 67.04 10.19 212 140866 20812 34795041
Sleep terror 66.52 10.19 63 141015 2255 34813598
Immunisation 64.53 10.19 45 141033 1032 34814821
Anosmia 63.82 10.19 80 140998 3944 34811909
Renal failure 63.79 10.19 806 140272 129751 34686102
Hepatic cytolysis 62.56 10.19 163 140915 14333 34801520
Atrial tachycardia 58.66 10.19 73 141005 3572 34812281
Occult blood 58.50 10.19 39 141039 829 34815024
Facial pain 56.15 10.19 72 141006 3632 34812221
Carotid artery occlusion 55.64 10.19 72 141006 3665 34812188
Hepatojugular reflux 55.57 10.19 33 141045 568 34815285
Pericarditis 54.48 10.19 135 140943 11510 34804343
Pancreatitis acute 50.24 10.19 236 140842 27905 34787948
Drug resistance 49.94 10.19 21 141057 25906 34789947
Foetal exposure during pregnancy 49.92 10.19 48 141030 38053 34777800
Hypertensive nephropathy 48.14 10.19 28 141050 463 34815390
Electrocardiogram Q wave abnormal 47.75 10.19 27 141051 422 34815431
Product dose omission issue 46.27 10.19 288 140790 119423 34696430
Gamma-glutamyltransferase increased 43.60 10.19 233 140845 28998 34786855
Systolic dysfunction 43.21 10.19 54 141024 2654 34813199
Drug reaction with eosinophilia and systemic symptoms 43.18 10.19 254 140824 32758 34783095
Ventricular hypokinesia 42.97 10.19 79 140999 5473 34810380
Hypergastrinaemia 42.90 10.19 15 141063 65 34815788
Jaundice 42.80 10.19 247 140831 31635 34784218
Degenerative mitral valve disease 41.36 10.19 21 141057 261 34815592
Hyperkalaemia 39.85 10.19 442 140636 68947 34746906
Disease progression 39.73 10.19 264 140814 107813 34708040
Migraine 39.18 10.19 157 140921 17321 34798532
Drug ineffective for unapproved indication 38.53 10.19 24 141054 23691 34792162
Nipple swelling 38.43 10.19 21 141057 306 34815547
Gastric polyps 38.43 10.19 35 141043 1191 34814662
Colitis microscopic 37.92 10.19 47 141031 2290 34813563
Nicotine dependence 37.44 10.19 26 141052 592 34815261
Therapy non-responder 37.10 10.19 63 141015 39083 34776770
Drug intolerance 37.08 10.19 120 140958 59450 34756403
Pulmonary vascular disorder 36.98 10.19 27 141051 667 34815186
Nephropathy 35.88 10.19 76 141002 5841 34810012
Rash maculo-papular 34.72 10.19 215 140863 28236 34787617
Lung disorder 34.40 10.19 249 140829 34447 34781406
Diabetic nephropathy 33.26 10.19 42 141036 2086 34813767
Chest pain 33.12 10.19 706 140372 126056 34689797
Pain of skin 33.10 10.19 75 141003 6034 34809819
Hepatitis cholestatic 32.91 10.19 88 140990 7859 34807994
Cholestatic liver injury 32.81 10.19 44 141034 2320 34813533
Tinnitus 32.52 10.19 164 140914 19954 34795899
Therapeutic product effect incomplete 32.02 10.19 101 140977 50440 34765413
Chronic kidney disease-mineral and bone disorder 31.91 10.19 20 141058 381 34815472
Physical deconditioning 31.71 10.19 33 141045 1326 34814527
Gastrooesophageal reflux disease 31.40 10.19 261 140817 37663 34778190
Drug hypersensitivity 30.96 10.19 194 140884 80335 34735518
Thrombocytopenia 30.47 10.19 836 140242 155411 34660442
Hypokalaemia 30.37 10.19 364 140714 57850 34758003
Hiatus hernia 30.00 10.19 83 140995 7562 34808291
Cell death 29.89 10.19 42 141036 2315 34813538
Palpitations 29.87 10.19 269 140809 39717 34776136
Acute generalised exanthematous pustulosis 28.02 10.19 75 141003 6701 34809152
Subarachnoid haemorrhage 27.92 10.19 113 140965 12522 34803331
Hyponatraemia 27.90 10.19 479 140599 82212 34733641
Intentional overdose 27.86 10.19 87 140991 43587 34772266
Eye injury 27.86 10.19 25 141053 834 34815019
Hemiplegia 27.66 10.19 76 141002 6896 34808957
Vascular purpura 27.64 10.19 35 141043 1743 34814110
Mixed liver injury 27.62 10.19 45 141033 2828 34813025
Anaemia macrocytic 27.22 10.19 46 141032 2980 34812873
Transient ischaemic attack 26.70 10.19 197 140881 27416 34788437
Inferior vena cava dilatation 26.41 10.19 23 141055 737 34815116
Idiopathic pulmonary fibrosis 25.74 10.19 49 141029 3485 34812368
Occupational dermatitis 25.66 10.19 11 141067 90 34815763
Abdominal pain upper 25.17 10.19 417 140661 71073 34744780
Eczema 24.85 10.19 143 140935 18293 34797560
Cardiac failure 24.73 10.19 511 140567 90737 34725116
Ocular myasthenia 24.58 10.19 14 141064 222 34815631
Eosinophilic colitis 24.53 10.19 14 141064 223 34815630
Granulomatous rosacea 24.00 10.19 12 141066 144 34815709
Helicobacter gastritis 23.59 10.19 27 141051 1209 34814644
Therapy interrupted 23.47 10.19 13 141065 13684 34802169
Tubulointerstitial nephritis and uveitis syndrome 23.41 10.19 10 141068 81 34815772
Eye pruritus 23.40 10.19 75 141003 7414 34808439
Product used for unknown indication 23.17 10.19 24 141054 959 34814894
Face oedema 23.11 10.19 100 140978 11416 34804437
Contraindicated product administered 22.81 10.19 32 141046 21449 34794404
Weight increased 22.64 10.19 253 140825 92780 34723073
Injection site pain 22.62 10.19 81 140997 38924 34776929
Ventricular tachycardia 22.58 10.19 184 140894 26395 34789458
Hypophosphataemic osteomalacia 22.45 10.19 11 141067 126 34815727
Nipple pain 22.31 10.19 23 141055 914 34814939
Radiation pneumonitis 22.26 10.19 39 141039 2601 34813252
Dermatitis bullous 22.24 10.19 70 141008 6852 34809001
Joint swelling 22.14 10.19 146 140932 59744 34756109
Inappropriate antidiuretic hormone secretion 22.06 10.19 106 140972 12647 34803206
Rhabdomyolysis 21.97 10.19 392 140686 67771 34748082
Cholangitis 21.89 10.19 81 140997 8608 34807245
Cardiac aneurysm 21.84 10.19 23 141055 937 34814916
Helicobacter test positive 21.78 10.19 22 141056 853 34815000
Brain scan abnormal 21.67 10.19 22 141056 858 34814995
Device dependence 21.49 10.19 8 141070 43 34815810
Premature baby 21.10 10.19 29 141049 19604 34796249
Gastroenteritis eosinophilic 21.03 10.19 12 141066 191 34815662
Overlap syndrome 21.00 10.19 10 141068 107 34815746
Acute pulmonary oedema 20.68 10.19 71 141007 7272 34808581
Occupational exposure to air contaminants 20.58 10.19 11 141067 153 34815700
Muscle haemorrhage 20.54 10.19 46 141032 3672 34812181
Carotid arteriosclerosis 20.50 10.19 31 141047 1827 34814026
Hospitalisation 20.39 10.19 140 140938 56762 34759091
Poisoning 20.38 10.19 12 141066 12214 34803639
Diplopia 20.37 10.19 127 140951 16716 34799137
Vasculitis 20.35 10.19 95 140983 11201 34804652
Hyperchlorhydria 20.34 10.19 19 141059 668 34815185
Eosinophilic oesophagitis 20.31 10.19 14 141064 315 34815538
Febrile bone marrow aplasia 20.24 10.19 76 141002 8133 34807720
Myelosuppression 20.16 10.19 29 141049 19236 34796617
Neurotoxicity 19.96 10.19 26 141052 17984 34797869
Ureteric compression 19.89 10.19 13 141065 267 34815586
Renal cyst 19.84 10.19 81 140997 9012 34806841
Hyperthermia 19.83 10.19 90 140988 10487 34805366
Mitral valve incompetence 19.55 10.19 115 140963 14828 34801025
Respiratory depression 19.55 10.19 22 141056 16223 34799630
Gastric cancer 19.50 10.19 64 141014 6405 34809448
Cardiac arrest 19.46 10.19 272 140806 95887 34719966
Multiple sclerosis relapse 19.07 10.19 15 141063 13118 34802735
Hyperkaliuria 19.01 10.19 9 141069 95 34815758
Rash papular 18.93 10.19 87 140991 10191 34805662
Haematotoxicity 18.63 10.19 5 141073 8189 34807664
Cataract 18.46 10.19 174 140904 26012 34789841
Physical examination abnormal 18.31 10.19 13 141065 307 34815546
Urticaria papular 18.20 10.19 8 141070 70 34815783
Nerve degeneration 18.14 10.19 11 141067 197 34815656
Cardiac failure congestive 18.13 10.19 232 140846 83038 34732815
Polyp 18.08 10.19 45 141033 3847 34812006
Condition aggravated 18.02 10.19 615 140463 191581 34624272
Phaeochromocytoma malignant 18.00 10.19 8 141070 72 34815781
Hypotension 17.93 10.19 722 140356 220927 34594926
Cross sensitivity reaction 17.87 10.19 25 141053 1372 34814481
Hepatic haematoma 17.55 10.19 14 141064 396 34815457
Pulmonary valve disease 17.50 10.19 13 141065 330 34815523
Craniotabes 17.47 10.19 5 141073 9 34815844
Poisoning deliberate 17.43 10.19 5 141073 7839 34808014
Troponin T increased 17.43 10.19 33 141045 2338 34813515
Muscle twitching 17.39 10.19 85 140993 10213 34805640
Myoglobinaemia 17.37 10.19 9 141069 117 34815736
Wheezing 17.36 10.19 97 140981 41305 34774548
Neuropsychiatric lupus 17.13 10.19 5 141073 10 34815843
Duodenal polyp 17.04 10.19 11 141067 221 34815632
Synovitis 16.98 10.19 19 141059 14047 34801806
Lethargy 16.88 10.19 97 140981 41025 34774828
Hypovitaminosis 16.63 10.19 16 141062 584 34815269
No adverse event 16.59 10.19 43 141035 22884 34792969
Sensitisation 16.55 10.19 10 141068 178 34815675
Xerosis 16.54 10.19 16 141062 588 34815265
Amnesia 16.54 10.19 172 140906 26391 34789462
Hypoparathyroidism 16.52 10.19 16 141062 589 34815264
Carotid artery stenosis 16.35 10.19 51 141027 4968 34810885
Type III immune complex mediated reaction 16.35 10.19 12 141066 299 34815554
Pathogen resistance 16.24 10.19 9 141069 9473 34806380
Anticoagulation drug level increased 16.12 10.19 15 141063 525 34815328
Febrile neutropenia 16.01 10.19 425 140653 136424 34679429
Dermatitis exfoliative 15.98 10.19 61 141017 6578 34809275
Coronary artery stenosis 15.97 10.19 79 140999 9537 34806316
Aggression 15.95 10.19 92 140986 38872 34776981
Acute coronary syndrome 15.68 10.19 101 140977 13444 34802409
Pancreatitis 15.64 10.19 232 140846 38659 34777194
Oesophagitis ulcerative 15.60 10.19 18 141060 813 34815040
Sepsis 15.60 10.19 533 140545 166028 34649825
Sudden death 15.59 10.19 110 140968 15091 34800762
Akinesia 15.56 10.19 30 141048 2154 34813699
Fixed eruption 15.50 10.19 26 141052 1674 34814179
Immune reconstitution inflammatory syndrome 15.47 10.19 8 141070 8751 34807102
Prurigo 15.45 10.19 16 141062 639 34815214
Large intestine polyp 15.33 10.19 68 141010 7846 34808007
Circumoral oedema 15.29 10.19 7 141071 68 34815785
Ventricular arrhythmia 15.17 10.19 53 141025 5475 34810378
Vitamin B12 deficiency 15.07 10.19 43 141035 3988 34811865
Hepatotoxicity 15.01 10.19 41 141037 21444 34794409
Jaundice cholestatic 14.97 10.19 48 141030 4746 34811107
Respiratory distress 14.83 10.19 214 140864 35451 34780402
Cerebral artery thrombosis 14.82 10.19 17 141061 763 34815090
Duodenitis 14.76 10.19 48 141030 4780 34811073
Bladder cancer 14.69 10.19 27 141051 16251 34799602
Brief psychotic disorder with marked stressors 14.66 10.19 10 141068 221 34815632
Dehydration 14.65 10.19 653 140425 129316 34686537
Renal haemangioma 14.62 10.19 5 141073 20 34815833
Peripheral venous disease 14.56 10.19 33 141045 2655 34813198
Blindness 14.53 10.19 107 140971 14879 34800974
Venoocclusive liver disease 14.48 10.19 7 141071 7959 34807894
Ventricular fibrillation 14.44 10.19 46 141032 22908 34792945
Hyperkinetic heart syndrome 14.44 10.19 8 141070 120 34815733
Pericardial disease 14.40 10.19 13 141065 437 34815416
Disturbance in attention 14.31 10.19 164 140914 25781 34790072
Low birth weight baby 14.29 10.19 7 141071 7898 34807955
Neuroleptic malignant syndrome 14.27 10.19 32 141046 17902 34797951
Drug dependence 14.23 10.19 50 141028 24167 34791686
High frequency ablation 14.20 10.19 9 141069 175 34815678
COVID-19 14.08 10.19 224 140854 77326 34738527
Psychotic disorder 14.03 10.19 51 141027 24401 34791452
Aortic valve incompetence 14.01 10.19 54 141024 5850 34810003
Therapy partial responder 13.94 10.19 11 141067 9605 34806248
Haematoma muscle 13.94 10.19 22 141056 1346 34814507
Essential hypertension 13.90 10.19 35 141043 3013 34812840
Fracture delayed union 13.90 10.19 6 141072 50 34815803
Antiphospholipid antibodies positive 13.86 10.19 11 141067 309 34815544
Infection 13.83 10.19 271 140807 90644 34725209
Cholecystitis 13.82 10.19 82 140996 10606 34805247
Hepatic encephalopathy 13.76 10.19 104 140974 14581 34801272
Ischaemic stroke 13.74 10.19 123 140955 18127 34797726
Accidental exposure to product 13.66 10.19 19 141059 12783 34803070
Neuropathy peripheral 13.65 10.19 245 140833 83018 34732835
Benign abdominal neoplasm 13.65 10.19 7 141071 89 34815764
Food interaction 13.63 10.19 18 141060 935 34814918
Echocardiogram abnormal 13.57 10.19 19 141059 1044 34814809
Acquired cystic kidney disease 13.55 10.19 3 141075 0 34815853
Bronchial injury 13.55 10.19 3 141075 0 34815853
Eructation 13.54 10.19 46 141032 4685 34811168
Ventricular enlargement 13.52 10.19 15 141063 649 34815204
Dyspnoea at rest 13.51 10.19 40 141038 3788 34812065
Musculoskeletal stiffness 13.40 10.19 122 140956 46558 34769295
Crohn's disease 13.40 10.19 35 141043 3082 34812771
Respiratory arrest 13.28 10.19 63 141015 27980 34787873
Intentional product use issue 13.26 10.19 166 140912 59650 34756203
Loss of personal independence in daily activities 13.23 10.19 79 140999 33100 34782753
Neutropenic sepsis 13.18 10.19 22 141056 13745 34802108
Nephropathy toxic 13.12 10.19 19 141059 12569 34803284
Prostatitis Escherichia coli 13.12 10.19 5 141073 29 34815824
Oesophageal adenocarcinoma 13.10 10.19 17 141061 868 34814985
Septic shock 13.04 10.19 381 140697 71453 34744400
Unresponsive to stimuli 13.02 10.19 62 141016 27507 34788346
Chest expansion decreased 13.01 10.19 8 141070 147 34815706
Mucormycosis 12.82 10.19 4 141074 5938 34809915
Oesophageal candidiasis 12.81 10.19 43 141035 4353 34811500
Antibody test abnormal 12.81 10.19 9 141069 209 34815644
Rash 12.81 10.19 752 140326 222000 34593853
Essential tremor 12.77 10.19 16 141062 788 34815065
Laboratory test abnormal 12.73 10.19 41 141037 20350 34795503
Hepatitis 12.69 10.19 150 140928 23754 34792099
Cardiac discomfort 12.68 10.19 14 141064 602 34815251
C-reactive protein abnormal 12.58 10.19 10 141068 8700 34807153
Rebound acid hypersecretion 12.57 10.19 7 141071 106 34815747
Cancer pain 12.52 10.19 31 141047 2641 34813212
Treatment noncompliance 12.24 10.19 65 141013 28035 34787818
Blood alkaline phosphatase increased 12.15 10.19 185 140893 30990 34784863
Appendicitis 12.12 10.19 26 141052 14781 34801072
Thrombocytopenic purpura 12.09 10.19 19 141059 1158 34814695
Epstein-Barr virus infection 12.01 10.19 8 141070 7620 34808233
Exposure during pregnancy 12.00 10.19 11 141067 8923 34806930
Renal atrophy 11.99 10.19 19 141059 1166 34814687
Progressive multifocal leukoencephalopathy 11.99 10.19 13 141065 9751 34806102
Hepatocellular carcinoma 11.98 10.19 61 141017 7448 34808405
Renal mass 11.91 10.19 24 141054 1780 34814073
Abnormal behaviour 11.88 10.19 56 141022 24913 34790940
Hyperparathyroidism secondary 11.74 10.19 22 141056 1546 34814307
Oral pustule 11.67 10.19 9 141069 242 34815611
Pruritus 11.63 10.19 692 140386 141289 34674564
Intestinal obstruction 11.59 10.19 142 140936 22680 34793173
Fatigue 11.52 10.19 1315 139763 369338 34446515
Infective exacerbation of chronic obstructive airways disease 11.48 10.19 24 141054 1827 34814026
Achlorhydria 11.48 10.19 3 141075 3 34815850
Renal tubular disorder 11.46 10.19 43 141035 4600 34811253
Malnutrition 11.35 10.19 89 140989 12620 34803233
Arthropathy 11.30 10.19 63 141015 26844 34789009
Excessive cerumen production 11.29 10.19 10 141068 328 34815525
Stevens-Johnson syndrome 11.27 10.19 120 140958 18519 34797334
Hyperhidrosis 11.26 10.19 392 140686 75300 34740553
Pulmonary oedema 11.26 10.19 130 140948 47399 34768454
Pain 11.22 10.19 694 140384 203981 34611872
Prostate cancer 11.22 10.19 104 140974 39545 34776308
Sacroiliitis 11.20 10.19 21 141057 1477 34814376
Oedema peripheral 11.19 10.19 591 140487 119221 34696632
False negative investigation result 11.12 10.19 8 141070 193 34815660
Nasopharyngitis 11.12 10.19 207 140871 69761 34746092
Septic arthritis staphylococcal 11.10 10.19 12 141066 504 34815349
Gastritis 11.06 10.19 136 140942 21737 34794116
Dyspepsia 11.04 10.19 209 140869 36523 34779330
Major depression 11.00 10.19 42 141036 4530 34811323
Suicide attempt 10.89 10.19 103 140975 39013 34776840
Cardiorenal syndrome 10.87 10.19 14 141064 709 34815144
Dialysis 10.85 10.19 80 140998 11128 34804725
Thrombosis 10.82 10.19 141 140937 50317 34765536
Enterochromaffin cell hyperplasia 10.82 10.19 4 141074 21 34815832
Dry skin 10.82 10.19 182 140896 31105 34784748
Cerebral haematoma 10.78 10.19 42 141036 4573 34811280
Erythema of eyelid 10.76 10.19 16 141062 929 34814924
Blood urea decreased 10.75 10.19 17 141061 1042 34814811
Toxic epidermal necrolysis 10.69 10.19 134 140944 21512 34794341
Anal erosion 10.67 10.19 4 141074 22 34815831
Lumbar radiculopathy 10.64 10.19 15 141063 829 34815024
Intentional self-injury 10.61 10.19 25 141053 13746 34802107
Therapeutic response decreased 10.56 10.19 72 141006 29241 34786612
Heat stroke 10.50 10.19 16 141062 949 34814904
Carbohydrate antigen 19-9 increased 10.48 10.19 8 141070 212 34815641
Oesophageal dilatation 10.44 10.19 8 141070 213 34815640
Insulin autoimmune syndrome 10.37 10.19 9 141069 287 34815566
Microcytic anaemia 10.37 10.19 27 141051 2373 34813480
Acute graft versus host disease in skin 10.36 10.19 4 141074 5197 34810656
Drug interaction 10.33 10.19 1052 140026 224894 34590959
Barrett's oesophagus 10.29 10.19 11 141067 456 34815397
Coombs negative haemolytic anaemia 10.29 10.19 7 141071 154 34815699
Thrombotic cerebral infarction 10.28 10.19 10 141068 370 34815483
Platelet toxicity 10.28 10.19 3 141075 6 34815847
Psoriatic arthropathy 10.26 10.19 43 141035 19755 34796098
Nasal crusting 10.26 10.19 10 141068 371 34815482
Syringe issue 10.26 10.19 5 141073 5659 34810194

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Chronic kidney disease 596.68 9.27 993 313211 65161 79365023
Drug ineffective 466.83 9.27 2437 311767 1078476 78351708
Completed suicide 453.84 9.27 200 314004 245567 79184617
Toxicity to various agents 368.96 9.27 687 313517 420853 79009331
Hepatocellular injury 316.44 9.27 626 313578 46967 79383217
Interstitial lung disease 307.49 9.27 1060 313144 111540 79318644
Cholestasis 302.40 9.27 648 313556 51461 79378723
Off label use 300.04 9.27 2220 311984 904995 78525189
Pemphigus 298.75 9.27 25 314179 99557 79330627
Synovitis 290.47 9.27 115 314089 150619 79279565
Acute kidney injury 289.08 9.27 3222 310982 516182 78914002
Death 273.14 9.27 1226 312978 565288 78864896
Anti-cyclic citrullinated peptide antibody positive 272.80 9.27 13 314191 83130 79347054
Hand deformity 252.43 9.27 51 314153 103868 79326316
Drug abuse 243.10 9.27 172 314032 162519 79267665
Glossodynia 240.26 9.27 56 314148 103281 79326903
Maternal exposure during pregnancy 239.72 9.27 119 314085 136419 79293765
Duodenal ulcer perforation 221.68 9.27 9 314195 66202 79363982
End stage renal disease 219.96 9.27 256 313948 11964 79418220
Wound 196.89 9.27 106 314098 116073 79314111
Toxic skin eruption 186.83 9.27 324 313880 21969 79408215
Carotid artery thrombosis 186.73 9.27 128 314076 2925 79427259
Neurologic neglect syndrome 180.46 9.27 123 314081 2784 79427400
Systemic lupus erythematosus 179.75 9.27 129 314075 121020 79309164
Eosinophilia 166.31 9.27 473 313731 44872 79385312
Arthropathy 164.26 9.27 278 313926 176833 79253351
Sensitisation 163.80 9.27 122 314082 3189 79426995
Hypomagnesaemia 159.24 9.27 476 313728 46435 79383749
Product use in unapproved indication 158.95 9.27 483 313721 249876 79180308
Treatment failure 154.09 9.27 272 313932 170214 79259970
Contraindicated product administered 152.89 9.27 240 313964 157298 79272886
Hemiplegia 152.02 9.27 237 313967 14702 79415482
Helicobacter infection 152.00 9.27 43 314161 69661 79360523
Cardiospasm 146.49 9.27 114 314090 3187 79426997
Adjustment disorder 145.50 9.27 123 314081 3877 79426307
Agranulocytosis 145.43 9.27 449 313755 44581 79385603
Hypocalcaemia 142.36 9.27 477 313727 49447 79380737
Tubulointerstitial nephritis 141.35 9.27 400 313804 37835 79392349
Folliculitis 141.29 9.27 24 314180 55356 79374828
Polycystic ovaries 139.10 9.27 117 314087 3662 79426522
Joint swelling 137.36 9.27 627 313577 288019 79142165
Drug intolerance 137.14 9.27 555 313649 263564 79166620
Personality disorder 136.96 9.27 144 314060 6002 79424182
Hyponatraemia 136.04 9.27 1180 313024 176668 79253516
Cholecystitis chronic 135.74 9.27 181 314023 9725 79420459
Palmoplantar keratoderma 134.62 9.27 114 314090 3602 79426582
Discomfort 130.02 9.27 183 314021 125434 79304750
Muscle injury 128.50 9.27 19 314185 48542 79381642
Rheumatoid factor positive 128.48 9.27 38 314166 59801 79370383
Pruritus genital 127.53 9.27 120 314084 4366 79425818
Renal failure 122.17 9.27 1270 312934 199698 79230486
Gastrooesophageal reflux disease 120.46 9.27 763 313441 103483 79326701
Alopecia 120.19 9.27 486 313718 230869 79199315
Ejection fraction 119.91 9.27 87 314117 2182 79428002
Exposure during pregnancy 117.47 9.27 135 314069 100997 79329187
Sleep terror 114.93 9.27 113 314091 4345 79425839
Infusion related reaction 113.19 9.27 494 313710 229743 79200441
Renal injury 112.91 9.27 223 313981 16704 79413480
Rash maculo-papular 109.60 9.27 475 313729 55603 79374581
Tension headache 105.38 9.27 136 314068 7075 79423109
Biliary dyskinesia 102.46 9.27 83 314121 2462 79427722
Swelling 102.30 9.27 472 313732 216239 79213945
Psoriatic arthropathy 100.87 9.27 95 314109 77904 79352280
Hepatic enzyme increased 99.03 9.27 377 313827 182233 79247951
C-reactive protein abnormal 98.01 9.27 34 314170 48333 79381851
Immunisation 96.52 9.27 75 314129 2092 79428092
Atrial tachycardia 95.70 9.27 129 314075 7004 79423180
Carotid artery occlusion 94.63 9.27 133 314071 7514 79422670
Drug reaction with eosinophilia and systemic symptoms 92.22 9.27 498 313706 63746 79366438
Dysphagia 92.12 9.27 808 313396 121328 79308856
Anosmia 90.96 9.27 141 314063 8703 79421481
Rhinitis allergic 90.89 9.27 169 314035 12100 79418084
Abdominal pain upper 90.18 9.27 1309 312895 222510 79207674
Inappropriate antidiuretic hormone secretion 89.29 9.27 267 313937 26046 79404138
Drug resistance 86.70 9.27 29 314175 42184 79388000
Nephrogenic anaemia 86.20 9.27 91 314113 3811 79426373
Therapeutic product effect decreased 83.33 9.27 347 313857 163516 79266668
Pancreatitis acute 80.56 9.27 398 313806 49206 79380978
Gastric polyps 80.32 9.27 86 314118 3661 79426523
Acute generalised exanthematous pustulosis 79.55 9.27 196 314008 17058 79413126
Irritable bowel syndrome 77.93 9.27 78 314126 62163 79368021
Condition aggravated 77.25 9.27 1450 312754 499674 78930510
Coordination abnormal 77.01 9.27 194 314010 17118 79413066
Intentional overdose 75.66 9.27 193 314011 105767 79324417
Blister 75.39 9.27 231 313973 119245 79310939
Hypertensive nephropathy 75.33 9.27 48 314156 966 79429218
Hiatus hernia 74.84 9.27 232 313972 23080 79407104
Affect lability 74.69 9.27 148 314056 11111 79419073
Product use issue 74.46 9.27 502 313702 209320 79220864
Sleep disorder due to general medical condition, insomnia type 73.39 9.27 40 314164 43516 79386668
Mobility decreased 73.05 9.27 242 313962 121933 79308251
Gamma-glutamyltransferase increased 71.91 9.27 414 313790 54266 79375918
Motor dysfunction 70.73 9.27 170 314034 14563 79415621
Pericarditis 70.53 9.27 195 314009 104041 79326143
Therapy non-responder 68.35 9.27 165 314039 92140 79338044
Palpitations 67.62 9.27 780 313424 125830 79304354
Hepatic cytolysis 65.85 9.27 246 313958 26905 79403279
Fatigue 65.35 9.27 2997 311207 926730 78503454
Systemic lupus erythematosus rash 65.21 9.27 56 314148 1804 79428380
Transient ischaemic attack 62.28 9.27 388 313816 52307 79377877
Peripheral swelling 62.07 9.27 721 313483 268896 79161288
Intentional product use issue 61.72 9.27 349 313855 151763 79278421
Knee arthroplasty 61.61 9.27 48 314156 43200 79386984
Bronchial neoplasm 61.49 9.27 33 314171 475 79429709
Sensory loss 61.40 9.27 149 314055 12842 79417342
Sleep apnoea syndrome 60.17 9.27 294 313910 36184 79394000
Vascular purpura 59.29 9.27 67 314137 3031 79427153
Nephrectomy 59.02 9.27 56 314148 2059 79428125
Hypokalaemia 58.20 9.27 843 313361 143197 79286987
Hypergastrinaemia 58.09 9.27 24 314180 182 79430002
Facial pain 57.68 9.27 141 314063 12209 79417975
Hip arthroplasty 57.16 9.27 35 314169 35721 79394463
Loss of employment 56.56 9.27 60 314144 2527 79427657
Nephropathy 56.35 9.27 121 314083 9617 79420567
Pancreatitis 56.08 9.27 462 313742 68113 79362071
Lower respiratory tract infection 55.43 9.27 291 313913 128929 79301255
Hypothyroidism 55.34 9.27 375 313829 52017 79378167
Jaundice 55.25 9.27 380 313824 52969 79377215
Carpal tunnel syndrome 55.14 9.27 186 314018 19342 79410842
Disease progression 54.54 9.27 464 313740 183898 79246286
Gastritis 54.01 9.27 349 313855 47644 79382540
Cholestatic liver injury 53.95 9.27 81 314123 4860 79425324
Cross sensitivity reaction 52.67 9.27 69 314135 3643 79426541
Ill-defined disorder 52.62 9.27 113 314091 65762 79364422
Pregnancy 52.49 9.27 20 314184 26831 79403353
Hepatojugular reflux 51.46 9.27 32 314172 616 79429568
Device expulsion 51.00 9.27 19 314185 25842 79404342
Hypersensitivity 50.83 9.27 727 313477 261512 79168672
Ejection fraction abnormal 50.54 9.27 55 314149 2385 79427799
Dermatitis bullous 49.71 9.27 146 314058 14099 79416085
Sedation complication 49.67 9.27 3 314201 15666 79414518
Therapy interrupted 49.66 9.27 31 314173 31310 79398874
Stomatitis 49.16 9.27 357 313847 146400 79283784
Diplopia 48.41 9.27 260 313944 33206 79396978
Presbyacusis 48.33 9.27 56 314148 2604 79427580
Epigastric discomfort 47.88 9.27 100 314104 7796 79422388
Bone erosion 47.18 9.27 7 314197 17840 79412344
Lung disorder 46.97 9.27 505 313699 80052 79350132
Subarachnoid haemorrhage 46.85 9.27 206 313998 24259 79405925
Hyperkalaemia 45.21 9.27 667 313537 113731 79316453
Nasopharyngitis 44.69 9.27 717 313487 253164 79177020
Rhabdomyolysis 44.63 9.27 611 313593 102520 79327664
Myelosuppression 44.43 9.27 56 314148 40240 79389944
Anxiety 44.42 9.27 1288 312916 247224 79182960
Angioedema 44.03 9.27 476 313728 75559 79354625
Weight increased 43.78 9.27 799 313405 276587 79153597
Diabetic nephropathy 43.72 9.27 56 314148 2891 79427293
Hepatitis cholestatic 43.68 9.27 137 314067 13715 79416469
Eczema 43.61 9.27 293 313911 40525 79389659
Tenosynovitis stenosans 43.34 9.27 57 314147 3021 79427163
Chest pain 43.26 9.27 1436 312768 280868 79149316
Occult blood 43.17 9.27 43 314161 1680 79428504
Cell death 42.95 9.27 71 314133 4628 79425556
Poisoning 42.88 9.27 23 314181 25249 79404935
Gallbladder disorder 42.63 9.27 170 314034 19170 79411014
Cholecystitis 42.52 9.27 187 314017 22025 79408159
Musculoskeletal stiffness 42.22 9.27 463 313741 174545 79255639
Pain of skin 41.98 9.27 140 314064 14473 79415711
Tinnitus 41.96 9.27 309 313895 44024 79386160
Eating disorder 41.73 9.27 177 314027 20520 79409664
Thrombocytopenia 41.60 9.27 1353 312851 263906 79166278
Angina pectoris 41.48 9.27 347 313857 51385 79378799
Nasal turbinate hypertrophy 41.43 9.27 29 314175 686 79429498
Ventricular tachycardia 41.25 9.27 295 313909 41640 79388544
Cardiac failure 41.07 9.27 847 313357 153995 79276189
Iron deficiency anaemia 40.98 9.27 205 313999 25467 79404717
Renal disorder 40.73 9.27 295 313909 41810 79388374
Premature delivery 40.34 9.27 21 314183 23446 79406738
Mixed liver injury 40.27 9.27 91 314113 7487 79422697
Pleural thickening 40.11 9.27 54 314150 2928 79427256
Aphasia 39.92 9.27 318 313886 46414 79383770
Drug hypersensitivity 39.70 9.27 886 313318 298030 79132154
Cardiac arrest 39.66 9.27 460 313744 171636 79258548
Degenerative mitral valve disease 39.64 9.27 21 314183 294 79429890
Nipple swelling 39.27 9.27 21 314183 300 79429884
Hemiparesis 39.00 9.27 247 313957 33486 79396698
Nephritic syndrome 38.73 9.27 23 314181 406 79429778
Muscle haemorrhage 38.45 9.27 80 314124 6220 79423964
Neurotoxicity 38.19 9.27 43 314161 32475 79397709
Pleural fibrosis 38.14 9.27 63 314141 4104 79426080
Product dose omission issue 38.13 9.27 716 313488 246821 79183363
Endometrial ablation 37.81 9.27 30 314174 863 79429321
Vasculitis 37.66 9.27 197 314007 24905 79405279
Electrocardiogram Q wave abnormal 37.56 9.27 26 314178 604 79429580
Obesity 37.51 9.27 50 314154 35075 79395109
Neutropenic sepsis 37.35 9.27 31 314173 27033 79403151
Gallbladder injury 37.30 9.27 34 314170 1187 79428997
Anaemia 37.27 9.27 2126 312078 442889 78987295
Red blood cell sedimentation rate abnormal 37.18 9.27 18 314186 20945 79409239
Haematotoxicity 36.88 9.27 8 314196 15511 79414673
Live birth 36.58 9.27 14 314190 18730 79411454
Rash papular 36.40 9.27 177 314027 21739 79408445
Chronic kidney disease-mineral and bone disorder 36.24 9.27 24 314180 517 79429667
Accidental exposure to product 36.15 9.27 42 314162 31280 79398904
Face oedema 35.67 9.27 211 313993 27925 79402259
Device dependence 34.79 9.27 12 314192 51 79430133
Blood test abnormal 34.58 9.27 150 314054 17560 79412624
Pain 34.17 9.27 2351 311853 701451 78728733
Vitamin B12 deficiency 34.17 9.27 83 314121 7158 79423026
Dry eye 33.59 9.27 255 313949 36676 79393508
Phlebitis 33.24 9.27 93 314111 8737 79421447
Impaired work ability 32.72 9.27 159 314045 19522 79410662
Injection site pain 32.72 9.27 340 313864 129498 79300686
Infection 32.49 9.27 715 313489 240997 79189187
Blood magnesium increased 32.08 9.27 53 314151 3453 79426731
Sleep disorder due to a general medical condition 31.87 9.27 126 314078 14151 79416033
Arterial occlusive disease 31.77 9.27 89 314115 8367 79421817
Dehydration 31.75 9.27 1237 312967 246950 79183234
Blindness 31.69 9.27 206 313998 28177 79402007
Drug ineffective for unapproved indication 31.65 9.27 100 314104 51138 79379046
Post transplant lymphoproliferative disorder 31.48 9.27 4 314200 11460 79418724
Pancreatic neuroendocrine tumour 31.46 9.27 24 314180 651 79429533
Impaired healing 31.42 9.27 209 313995 87446 79342738
Bronchial haemorrhage 31.34 9.27 32 314172 1288 79428896
Cholangitis 31.18 9.27 116 314088 12660 79417524
Osteosclerosis 31.06 9.27 56 314148 3915 79426269
Malnutrition 30.65 9.27 172 314032 22330 79407854
Synovial fluid analysis 30.64 9.27 42 314162 2317 79427867
Anaemia macrocytic 30.63 9.27 68 314136 5529 79424655
Rheumatoid nodule 30.53 9.27 143 314061 17295 79412889
Occupational dermatitis 30.46 9.27 14 314190 141 79430043
Respiratory arrest 30.41 9.27 120 314084 57430 79372754
Eosinophilic fasciitis 30.32 9.27 17 314187 268 79429916
Post cholecystectomy syndrome 30.23 9.27 19 314185 373 79429811
Gastric disorder 29.96 9.27 251 313953 37182 79393002
Muscle spasticity 29.82 9.27 165 314039 21310 79408874
Muscle contractions involuntary 29.32 9.27 53 314151 3712 79426472
Sudden death 29.31 9.27 170 314034 22341 79407843
Acute graft versus host disease 29.29 9.27 3 314201 10164 79420020
Therapy partial responder 29.27 9.27 16 314188 17381 79412803
Drug interaction 29.26 9.27 1954 312250 413229 79016955
Cardiac disorder 29.03 9.27 391 313813 65366 79364818
Systolic dysfunction 29.02 9.27 53 314151 3742 79426442
Muscular weakness 28.68 9.27 833 313371 159896 79270288
Febrile neutropenia 28.61 9.27 692 313512 230307 79199877
Idiopathic pulmonary fibrosis 28.56 9.27 56 314148 4172 79426012
Eye pruritus 28.53 9.27 158 314046 20412 79409772
Urate nephropathy 28.32 9.27 14 314190 168 79430016
Electric shock 28.14 9.27 31 314173 1363 79428821
Medication error 28.09 9.27 157 314047 68485 79361699
Bunion operation 28.09 9.27 26 314178 926 79429258
Contusion 27.91 9.27 415 313789 148361 79281823
Rash 27.87 9.27 1933 312271 576425 78853759
Respiratory depression 27.84 9.27 41 314163 27589 79402595
Drug dependence 27.77 9.27 76 314128 40693 79389491
Injection site erythema 27.75 9.27 187 314017 78010 79352174
Sinus congestion 27.71 9.27 153 314051 19743 79410441
Synovial cyst 27.65 9.27 95 314109 9970 79420214
Pulmonary vascular disorder 27.50 9.27 27 314177 1036 79429148
Bronchial disorder 27.46 9.27 41 314163 2448 79427736
Gait inability 27.37 9.27 129 314075 58788 79371396
Therapeutic response decreased 27.31 9.27 153 314051 66700 79363484
Disturbance in attention 27.12 9.27 313 313891 50488 79379696
Laboratory test abnormal 26.93 9.27 43 314161 28005 79402179
Autoimmune disorder 26.92 9.27 16 314188 16596 79413588
Ventricular hypokinesia 26.75 9.27 89 314115 9190 79420994
Cholelithiasis 26.57 9.27 321 313883 52343 79377841
Hepatitis 26.54 9.27 336 313868 55391 79374793
Oesophagitis ulcerative 26.47 9.27 28 314176 1175 79429009
Rhinitis 26.35 9.27 122 314082 14685 79415499
Erythema dyschromicum perstans 26.32 9.27 10 314194 59 79430125
Blood alkaline phosphatase increased 26.25 9.27 374 313830 63290 79366894
Scleritis 26.22 9.27 55 314149 4301 79425883
Respiratory tract congestion 26.18 9.27 151 314053 19803 79410381
Inferior vena cava dilatation 26.11 9.27 24 314180 847 79429337
Nicotine dependence 26.11 9.27 25 314179 930 79429254
Hepatotoxicity 25.92 9.27 109 314095 51243 79378941
Adjustment disorder with depressed mood 25.36 9.27 3 314201 9083 79421101
Gallbladder polyp 25.34 9.27 25 314179 965 79429219
Febrile bone marrow aplasia 25.21 9.27 110 314094 12910 79417274
Neuroleptic malignant syndrome 24.85 9.27 44 314160 27515 79402669
Cholecystitis acute 24.81 9.27 112 314092 13339 79416845
Facet joint syndrome 24.58 9.27 7 314197 11295 79418889
Ulcer 24.54 9.27 202 314002 29770 79400414
Eyelid oedema 24.52 9.27 113 314091 13574 79416610
Immunodeficiency 24.26 9.27 30 314174 21738 79408446
Prescribed overdose 24.06 9.27 73 314131 37810 79392374
Aggression 24.01 9.27 111 314093 50847 79379337
Eosinophilic colitis 23.99 9.27 18 314186 476 79429708
Drug eruption 23.59 9.27 271 313933 43664 79386520
Carotid artery stenosis 23.49 9.27 82 314122 8676 79421508
Mucosal inflammation 23.34 9.27 188 314016 75392 79354792
Exposure to toxic agent 23.29 9.27 4 314200 9154 79421030
Abortion spontaneous 23.24 9.27 51 314153 29456 79400728
Hypoparathyroidism 23.18 9.27 25 314179 1073 79429111
Unresponsive to stimuli 23.16 9.27 127 314077 55661 79374523
Adenovirus infection 23.07 9.27 3 314201 8444 79421740
Nasal discharge discolouration 22.92 9.27 38 314166 2483 79427701
Dermatitis exfoliative 22.92 9.27 94 314110 10735 79419449
Radiation pneumonitis 22.91 9.27 49 314155 3884 79426300
Vulvovaginal burning sensation 22.85 9.27 30 314174 1587 79428597
Crepitations 22.84 9.27 89 314115 9928 79420256
Cerebral haematoma 22.74 9.27 76 314128 7866 79422318
Hyperthermia 22.70 9.27 135 314069 17902 79412282
Nerve injury 22.69 9.27 85 314119 9307 79420877
Abdominal discomfort 22.50 9.27 785 313419 249942 79180242
Grip strength decreased 22.47 9.27 32 314172 21837 79408347
Injection site pruritus 22.44 9.27 88 314116 42195 79387989
Burning sensation 22.43 9.27 340 313864 58292 79371892
Helicobacter test positive 22.38 9.27 27 314177 1311 79428873
Renal cyst 22.36 9.27 116 314088 14616 79415568
Lip oedema 22.29 9.27 65 314139 6251 79423933
Respiratory distress 22.20 9.27 338 313866 58001 79372183
Dry skin 22.17 9.27 384 313820 67611 79362573
Injection site bruising 21.98 9.27 85 314119 40917 79389267
Caesarean section 21.87 9.27 11 314193 12524 79417660
Diverticulum 21.73 9.27 116 314088 14780 79415404
Deafness neurosensory 21.54 9.27 68 314136 6830 79423354
Urticaria papular 21.52 9.27 12 314192 187 79429997
Axonal neuropathy 21.48 9.27 33 314171 2021 79428163
Nephrosclerosis 21.42 9.27 31 314173 1799 79428385
Injection site swelling 21.42 9.27 104 314100 47028 79383156
Physical examination abnormal 21.41 9.27 14 314190 295 79429889
Aspartate aminotransferase 21.36 9.27 18 314186 565 79429619
Nipple pain 21.18 9.27 22 314182 904 79429280
Pyelocaliectasis 21.04 9.27 22 314182 911 79429273
Lip dry 20.86 9.27 18 314186 15400 79414784
Occupational exposure to air contaminants 20.83 9.27 11 314193 153 79430031
Ocular myasthenia 20.82 9.27 15 314189 372 79429812
Disability 20.81 9.27 22 314182 17098 79413086
Hepatic haematoma 20.68 9.27 21 314183 840 79429344
Granulomatous rosacea 20.61 9.27 12 314192 204 79429980
Hypovitaminosis 20.47 9.27 24 314180 1130 79429054
Dermatitis exfoliative generalised 20.47 9.27 69 314135 7172 79423012
Acute coronary syndrome 20.40 9.27 148 314056 20985 79409199
Muscle twitching 20.33 9.27 167 314037 24597 79405587
Pathogen resistance 20.32 9.27 16 314188 14326 79415858
Subacute cutaneous lupus erythematosus 20.32 9.27 44 314160 3517 79426667
Hunger 20.26 9.27 57 314147 5371 79424813
Acute graft versus host disease in skin 20.25 9.27 3 314201 7655 79422529
Hyperparathyroidism secondary 20.15 9.27 37 314167 2623 79427561
Migraine 20.13 9.27 469 313735 87024 79343160
Fall 20.11 9.27 2205 311999 485424 78944760
Ureteric compression 20.04 9.27 13 314191 270 79429914
Rectosigmoid cancer 20.04 9.27 13 314191 270 79429914
Deformity 20.03 9.27 83 314121 9522 79420662
Nephropathy toxic 19.89 9.27 31 314173 20388 79409796
Campylobacter colitis 19.89 9.27 7 314197 32 79430152
Illness 19.79 9.27 105 314099 46406 79383778
Helicobacter gastritis 19.75 9.27 35 314169 2414 79427770
Breast cancer stage II 19.68 9.27 4 314200 8116 79422068
Cardiac aneurysm 19.68 9.27 27 314177 1491 79428693
Fear of injection 19.60 9.27 3 314201 7471 79422713
Troponin T increased 19.51 9.27 43 314161 3479 79426705
Tetany 19.49 9.27 37 314167 2691 79427493
Allergy to chemicals 19.47 9.27 36 314168 2566 79427618
Renal tubular disorder 19.40 9.27 63 314141 6423 79423761
Colitis microscopic 19.37 9.27 89 314115 10679 79419505
Pruritus 19.35 9.27 1806 312398 392842 79037342
Hyperlipidaemia 19.33 9.27 172 314032 25921 79404263
Hepatic encephalopathy 19.32 9.27 162 314042 24004 79406180
Cataract 19.25 9.27 348 313856 61772 79368412
Rebound acid hypersecretion 19.21 9.27 9 314195 95 79430089
Pulmonary valve disease 19.04 9.27 13 314191 295 79429889
Carotid arteriosclerosis 18.94 9.27 36 314168 2620 79427564
Immune reconstitution inflammatory syndrome 18.92 9.27 16 314188 13825 79416359
Mucormycosis 18.88 9.27 5 314199 8464 79421720
Acute pulmonary oedema 18.87 9.27 108 314096 14122 79416062
Hepatic function abnormal 18.75 9.27 398 313806 72709 79357475
Hypotension 18.72 9.27 1487 312717 438830 78991354
Genital infection female 18.68 9.27 8 314196 67 79430117
Hallucination 18.62 9.27 456 313748 85289 79344895
Dystonia 18.55 9.27 35 314169 21364 79408820
Hyperchlorhydria 18.45 9.27 31 314173 2048 79428136
Creatinine renal clearance decreased 18.37 9.27 29 314175 18973 79411211
Multi-organ disorder 18.36 9.27 35 314169 2553 79427631
Kidney infection 18.28 9.27 148 314056 21703 79408481
Abdominal pain 18.25 9.27 1777 312427 387792 79042392
Localised infection 18.21 9.27 81 314123 37494 79392690
Phaeochromocytoma malignant 18.19 9.27 8 314196 72 79430112
Therapy cessation 18.18 9.27 81 314123 37481 79392703
Pre-eclampsia 18.07 9.27 3 314201 7038 79423146
Renal tubular necrosis 18.01 9.27 164 314040 24875 79405309
Duodenal polyp 17.95 9.27 13 314191 325 79429859
Angina bullosa haemorrhagica 17.77 9.27 11 314193 210 79429974
Brain scan abnormal 17.77 9.27 23 314181 1200 79428984
Dialysis 17.65 9.27 129 314075 18333 79411851
Ischaemic stroke 17.62 9.27 204 314000 32927 79397257
Gangrene 17.56 9.27 76 314128 8888 79421296
Coronary artery stenosis 17.39 9.27 96 314108 12388 79417796
Nerve degeneration 17.32 9.27 12 314192 279 79429905
Heat stroke 17.30 9.27 27 314177 1676 79428508
Diarrhoea 17.26 9.27 3819 310385 876670 78553514
Substance abuse 17.25 9.27 10 314194 10516 79419668
Chronic graft versus host disease 17.16 9.27 3 314201 6778 79423406
Type III immune complex mediated reaction 17.13 9.27 17 314187 661 79429523
Gastric antral vascular ectasia 17.12 9.27 20 314184 938 79429246
Suicide attempt 17.09 9.27 227 313977 82705 79347479
Vertigo 17.05 9.27 374 313830 68708 79361476
Thrombocytopenic purpura 17.04 9.27 33 314171 2436 79427748
No adverse event 16.94 9.27 82 314122 37110 79393074
Dislocation of vertebra 16.92 9.27 5 314199 7875 79422309
Bone cyst 16.90 9.27 40 314164 3393 79426791
Myoglobinaemia 16.86 9.27 9 314195 128 79430056
Venoocclusive liver disease 16.85 9.27 13 314191 11758 79418426
Osteopenia 16.81 9.27 127 314077 18237 79411947
Hyperkinetic heart syndrome 16.80 9.27 9 314195 129 79430055
Psychotic disorder 16.77 9.27 95 314109 41307 79388877
Rash scarlatiniform 16.65 9.27 11 314193 236 79429948
Eructation 16.63 9.27 86 314118 10823 79419361
Hyperhidrosis 16.61 9.27 743 313461 150749 79279435
Hepatocellular carcinoma 16.55 9.27 75 314129 8946 79421238
Essential hypertension 16.51 9.27 57 314147 5996 79424188
Mesenteric panniculitis 16.44 9.27 13 314191 372 79429812
Bicytopenia 16.43 9.27 48 314156 4622 79425562
Septic shock 16.38 9.27 615 313589 122186 79307998
Haematoma 16.38 9.27 293 313911 51902 79378282
Cerebral infarction 16.38 9.27 262 313942 45414 79384770
Appendicitis 16.33 9.27 36 314168 20758 79409426
Liver function test increased 16.26 9.27 91 314113 39682 79390502
Prescription form tampering 16.24 9.27 13 314191 379 79429805
Overdose 16.22 9.27 578 313626 183628 79246556
Cerebellar haematoma 16.17 9.27 16 314188 620 79429564
Pleuritic pain 16.15 9.27 81 314123 10071 79420113
Injection site haemorrhage 16.11 9.27 56 314148 27814 79402370
Angina unstable 16.10 9.27 116 314088 16411 79413773
Nausea 16.09 9.27 4123 310081 953073 78477111
CSF volume increased 15.99 9.27 6 314198 34 79430150
Blood lactic acid increased 15.92 9.27 16 314188 12728 79417456
Salpingo-oophorectomy unilateral 15.90 9.27 18 314186 816 79429368
Cardiotoxicity 15.71 9.27 15 314189 12224 79417960
Bradypnoea 15.66 9.27 56 314148 5996 79424188
Bile duct stone 15.57 9.27 53 314151 5536 79424648
Lip swelling 15.56 9.27 237 313967 40674 79389510
Hyperphosphatasaemia 15.55 9.27 8 314196 105 79430079
Cardiothoracic ratio increased 15.54 9.27 7 314197 67 79430117
Antinuclear antibody positive 15.54 9.27 67 314137 7823 79422361
Regurgitation 15.41 9.27 34 314170 2753 79427431
Anticoagulation drug level increased 15.31 9.27 17 314187 754 79429430
Diverticulum oesophageal 15.30 9.27 9 314195 156 79430028
Gastrointestinal motility disorder 15.29 9.27 56 314148 6066 79424118
Inappropriate schedule of product administration 15.27 9.27 405 313799 133223 79296961
Schizophreniform disorder 15.25 9.27 9 314195 157 79430027
Myocardial infarction 15.24 9.27 879 313325 183250 79246934
Pulmonary arterial hypertension 15.24 9.27 175 314029 28191 79401993
Tongue oedema 15.24 9.27 62 314142 7055 79423129
Premature labour 15.19 9.27 7 314197 8383 79421801
Seizure 15.19 9.27 599 313605 188235 79241949
Purging 15.18 9.27 6 314198 40 79430144
Alanine aminotransferase abnormal 15.15 9.27 8 314196 8859 79421325
Melaena 15.14 9.27 330 313874 60560 79369624
Supraventricular extrasystoles 15.06 9.27 61 314143 6926 79423258
Adverse event 15.03 9.27 158 314046 60056 79370128
COVID-19 14.99 9.27 490 313714 157184 79273000
Transplant rejection 14.98 9.27 34 314170 19403 79410781
Oesophagitis 14.97 9.27 154 314050 24135 79406049
Stevens-Johnson syndrome 14.93 9.27 227 313977 38939 79391245
Cutaneous lupus erythematosus 14.79 9.27 35 314169 2968 79427216
Coronary artery disease 14.76 9.27 350 313854 65124 79365060
Transplant dysfunction 14.76 9.27 5 314199 7216 79422968
Graft versus host disease in skin 14.70 9.27 3 314201 6070 79424114
Sciatica 14.70 9.27 74 314130 33148 79397036
Microcytic anaemia 14.68 9.27 50 314154 5224 79424960
Hyperkaliuria 14.67 9.27 9 314195 169 79430015
Gastric cancer 14.66 9.27 79 314125 10100 79420084
Large intestine polyp 14.66 9.27 93 314111 12615 79417569
High frequency ablation 14.62 9.27 11 314193 292 79429892
Tooth disorder 14.62 9.27 163 314041 26070 79404114
Gastroenteritis eosinophilic 14.56 9.27 11 314193 294 79429890
Intervertebral discitis 14.54 9.27 47 314157 4781 79425403
Type I hypersensitivity 14.33 9.27 44 314160 4354 79425830
Prurigo 14.32 9.27 22 314182 1347 79428837
Escherichia pyelonephritis 14.29 9.27 14 314190 536 79429648
Normal newborn 14.28 9.27 5 314199 7067 79423117
Thrombophlebitis 14.21 9.27 56 314148 6279 79423905
Hypocapnia 14.21 9.27 15 314189 628 79429556
Chronic cutaneous lupus erythematosus 14.09 9.27 13 314191 461 79429723
Renal impairment 13.99 9.27 758 313446 157025 79273159
Malaise 13.95 9.27 2166 312038 487703 78942481
Treatment noncompliance 13.94 9.27 135 314069 52133 79378051
Amnesia 13.89 9.27 336 313868 62721 79367463
Small cell carcinoma 13.85 9.27 11 314193 317 79429867
Pancreatitis chronic 13.84 9.27 41 314163 3978 79426206
IIIrd nerve paresis 13.79 9.27 9 314195 189 79429995
Acute hepatitis B 13.75 9.27 13 314191 476 79429708
Sleep disorder 13.74 9.27 246 313958 85431 79344753
Shock haemorrhagic 13.73 9.27 130 314074 19930 79410254
Duodenitis 13.70 9.27 65 314139 7902 79422282
Complication of device insertion 13.69 9.27 4 314200 6346 79423838
Oesophageal adenocarcinoma 13.68 9.27 17 314187 851 79429333
Product used for unknown indication 13.67 9.27 23 314181 1521 79428663
Blood creatine phosphokinase decreased 13.67 9.27 18 314186 955 79429229
Systemic infection 13.67 9.27 11 314193 9741 79420443
Tooth demineralisation 13.62 9.27 3 314201 0 79430184
Bladder cancer 13.60 9.27 36 314168 19490 79410694
Haemorrhage intracranial 13.59 9.27 55 314149 26138 79404046
Blood immunoglobulin A increased 13.53 9.27 18 314186 965 79429219
Pericardial disease 13.52 9.27 14 314190 573 79429611
Xerosis 13.50 9.27 20 314184 1186 79428998
Haematoma muscle 13.45 9.27 31 314173 2584 79427600
Device difficult to use 13.35 9.27 20 314184 13365 79416819
Vulvovaginal pruritus 13.31 9.27 31 314173 2602 79427582
Food interaction 13.31 9.27 24 314180 1678 79428506
Cytomegalovirus infection reactivation 13.29 9.27 9 314195 8707 79421477
Gait disturbance 13.26 9.27 675 313529 206831 79223353
Renal hypertension 13.19 9.27 9 314195 204 79429980
Cardiorenal syndrome 13.19 9.27 23 314181 1566 79428618
Lethargy 13.17 9.27 233 313971 81059 79349125
Occupational exposure to product 13.16 9.27 15 314189 685 79429499
Unintentional medical device removal 13.11 9.27 7 314197 7705 79422479
Hypoalbuminaemia 13.11 9.27 135 314069 21162 79409022
Drug use disorder 13.10 9.27 9 314195 8642 79421542
Liver disorder 13.10 9.27 376 313828 72041 79358143
Angiopathy 13.08 9.27 59 314145 7023 79423161
Neurosis 13.02 9.27 12 314192 425 79429759
Epstein-Barr virus infection 13.01 9.27 23 314181 14393 79415791
Vitreous detachment 12.99 9.27 28 314176 2231 79427953
Drug specific antibody present 12.93 9.27 5 314199 6647 79423537
Pleurisy 12.92 9.27 78 314126 10397 79419787
Uveal melanoma 12.92 9.27 4 314200 11 79430173
Renal infarct 12.86 9.27 31 314173 2660 79427524
Aspergillus infection 12.84 9.27 36 314168 19125 79411059
Parkinsonism 12.79 9.27 29 314175 16555 79413629
Flatulence 12.76 9.27 238 313966 42486 79387698
Adrenocorticotropic hormone deficiency 12.76 9.27 21 314183 1364 79428820
Bronchopulmonary aspergillosis 12.75 9.27 45 314159 22249 79407935
Graft versus host disease 12.65 9.27 25 314179 15001 79415183
Nephritis allergic 12.65 9.27 15 314189 715 79429469
Cardio-respiratory arrest 12.63 9.27 328 313876 108182 79322002
Thymus disorder 12.62 9.27 10 314194 287 79429897
Sedation 12.62 9.27 137 314067 51758 79378426
Ventricular enlargement 12.62 9.27 15 314189 717 79429467
Cutaneous vasculitis 12.54 9.27 65 314139 8187 79421997
Granulocyte count increased 12.54 9.27 20 314184 1265 79428919
Catarrh 12.53 9.27 27 314177 2151 79428033
Gallbladder hypofunction 12.52 9.27 13 314191 534 79429650
Neutrophilia 12.41 9.27 8 314196 7943 79422241
General physical health deterioration 12.39 9.27 925 313279 274313 79155871
Ear infection 12.39 9.27 82 314122 34350 79395834
Sickle cell anaemia with crisis 12.32 9.27 8 314196 7914 79422270
Subdural haematoma 12.30 9.27 183 314021 31251 79398933
Cytomegalovirus infection 12.30 9.27 108 314096 42536 79387648
Burns second degree 12.27 9.27 30 314174 2598 79427586
Pneumobilia 12.26 9.27 9 314195 230 79429954
Sinus disorder 12.25 9.27 139 314065 22325 79407859
Renal atrophy 12.12 9.27 24 314180 1801 79428383
Photophobia 12.11 9.27 129 314075 20399 79409785
Cardiac murmur functional 12.09 9.27 5 314199 38 79430146
Multiple sclerosis relapse 12.07 9.27 121 314083 46412 79383772
Glomerular filtration rate increased 12.03 9.27 19 314185 1192 79428992
Placental calcification 11.99 9.27 4 314200 15 79430169
Cytomegalovirus viraemia 11.99 9.27 20 314184 12801 79417383
Intestinal infarction 11.96 9.27 20 314184 1316 79428868
Circumoral oedema 11.94 9.27 10 314194 311 79429873
X-ray abnormal 11.93 9.27 4 314200 5809 79424375
Drug tolerance 11.89 9.27 10 314194 8665 79421519
Cytokine release syndrome 11.84 9.27 88 314116 35910 79394274
Cerebral artery thrombosis 11.83 9.27 18 314186 1093 79429091
Withdrawal syndrome 11.78 9.27 60 314144 26794 79403390
Clinically isolated syndrome 11.77 9.27 5 314199 41 79430143
Ingrowing nail 11.73 9.27 31 314173 2816 79427368
Brain injury 11.69 9.27 17 314187 11500 79418684
Suicidal ideation 11.68 9.27 221 313983 76119 79354065
Dermatophytosis of nail 11.66 9.27 8 314196 183 79430001
Bronchopneumopathy 11.66 9.27 15 314189 778 79429406
Teeth brittle 11.65 9.27 12 314192 488 79429696
Gastric ulcer haemorrhage 11.64 9.27 68 314136 8959 79421225
Hyperuricaemia 11.60 9.27 83 314121 11716 79418468
Tubulointerstitial nephritis and uveitis syndrome 11.57 9.27 10 314194 325 79429859
Wrong technique in product usage process 11.57 9.27 213 313991 73662 79356522
Cellulitis 11.57 9.27 334 313870 108726 79321458
Platelet adhesiveness decreased 11.55 9.27 3 314201 3 79430181
Respiratory syncytial virus infection 11.52 9.27 12 314192 9390 79420794
Chest expansion decreased 11.51 9.27 8 314196 187 79429997
Ventricular fibrillation 11.50 9.27 76 314128 31850 79398334
Nocardiosis 11.49 9.27 4 314200 5675 79424509
Erosive oesophagitis 11.49 9.27 31 314173 2851 79427333
Haemolytic anaemia 11.47 9.27 114 314090 17706 79412478
Device use error 11.28 9.27 7 314197 7094 79423090
Colitis ischaemic 11.25 9.27 101 314103 15258 79414926
Therapeutic product effect incomplete 11.24 9.27 450 313754 141195 79288989
Hypomania 11.23 9.27 8 314196 7536 79422648
Purple glove syndrome 11.22 9.27 9 314195 263 79429921
Tricuspid valve incompetence 11.22 9.27 123 314081 19589 79410595
Vulval disorder 11.21 9.27 13 314191 605 79429579
Enterochromaffin cell hyperplasia 11.20 9.27 6 314198 86 79430098
Haemorrhoids 11.17 9.27 169 314035 28959 79401225
Aortic valve incompetence 11.15 9.27 70 314134 9460 79420724
Miosis 11.15 9.27 103 314101 15686 79414498
Eye injury 11.12 9.27 29 314175 2614 79427570
Traumatic haematoma 11.11 9.27 25 314179 2051 79428133
Mitral valve incompetence 11.06 9.27 166 314038 28399 79401785
Hypertriglyceridaemia 11.05 9.27 87 314117 12653 79417531
Rhinalgia 11.03 9.27 27 314177 2340 79427844
Finger deformity 11.02 9.27 8 314196 7466 79422718
Neutropenia 10.95 9.27 980 313224 286730 79143454
Creatinine renal clearance abnormal 10.94 9.27 12 314192 525 79429659
Heart rate decreased 10.93 9.27 203 314001 70113 79360071
Lipase increased 10.92 9.27 106 314098 16360 79413824
Hypoplastic anaemia 10.91 9.27 4 314200 21 79430163
Product substitution issue 10.90 9.27 125 314079 20131 79410053
Infusion site scar 10.88 9.27 10 314194 353 79429831
Drug effective for unapproved indication 10.88 9.27 5 314199 5996 79424188
Anal erythema 10.88 9.27 8 314196 205 79429979
Post-traumatic stress disorder 10.83 9.27 43 314161 4838 79425346
Erythema 10.80 9.27 1021 313183 222269 79207915
Arthralgia 10.78 9.27 2037 312167 569766 78860418
Abdominal strangulated hernia 10.73 9.27 6 314198 94 79430090
Lower limb fracture 10.68 9.27 51 314153 23164 79407020
Blood gastrin increased 10.66 9.27 5 314199 53 79430131
Hyponatraemic seizure 10.62 9.27 12 314192 543 79429641
Dyspepsia 10.62 9.27 527 313677 108160 79322024
Abnormal behaviour 10.61 9.27 92 314112 36329 79393855
Cerebrovascular accident 10.40 9.27 728 313476 154564 79275620
Hypoparathyroidism secondary 10.39 9.27 8 314196 220 79429964
Campylobacter gastroenteritis 10.36 9.27 19 314185 1346 79428838
Tongue pruritus 10.36 9.27 12 314192 558 79429626
Oesophageal candidiasis 10.35 9.27 67 314137 9151 79421033
Surgery 10.35 9.27 81 314123 32685 79397499
Hyperammonaemic encephalopathy 10.33 9.27 3 314201 4779 79425405
Tongue disorder 10.33 9.27 25 314179 13950 79416234
Arterial spasm 10.32 9.27 7 314197 157 79430027
Hypopnoea 10.30 9.27 45 314159 5284 79424900
Pericardial haemorrhage 10.30 9.27 40 314164 4455 79425729
Faecal vomiting 10.30 9.27 17 314187 1107 79429077
Nightmare 10.29 9.27 151 314053 25710 79404474
Cholecystectomy 10.25 9.27 68 314136 9364 79420820
Brief psychotic disorder with marked stressors 10.22 9.27 9 314195 300 79429884
Anaemia folate deficiency 10.22 9.27 9 314195 300 79429884
Feeling jittery 10.22 9.27 86 314118 12755 79417429
Distal intestinal obstruction syndrome 10.20 9.27 14 314190 773 79429411
Enterocolitis haemorrhagic 10.19 9.27 25 314179 2169 79428015
Anaemia vitamin B12 deficiency 10.19 9.27 14 314190 774 79429410
Circulatory collapse 10.17 9.27 97 314107 37571 79392613
False negative investigation result 10.15 9.27 9 314195 303 79429881
Hallucination, olfactory 10.11 9.27 11 314193 477 79429707
Neoplasm progression 10.09 9.27 143 314061 51539 79378645
Dysarthria 10.09 9.27 343 313861 67279 79362905
Extra dose administered 10.02 9.27 11 314193 8404 79421780
Biliary tract disorder 10.00 9.27 21 314183 1643 79428541
Eosinophilic oesophagitis 9.96 9.27 12 314192 582 79429602
Device malfunction 9.94 9.27 47 314157 21401 79408783
Hepatobiliary scan abnormal 9.90 9.27 5 314199 63 79430121
Anaphylactoid reaction 9.89 9.27 45 314159 5377 79424807
Prothrombin time ratio decreased 9.87 9.27 15 314189 910 79429274
Oedema peripheral 9.85 9.27 1137 313067 251151 79179033
Intentional self-injury 9.84 9.27 81 314123 32338 79397846
Purpura 9.84 9.27 119 314085 19408 79410776
Incorrect route of product administration 9.83 9.27 89 314115 34840 79395344
Therapeutic embolisation 9.83 9.27 11 314193 492 79429692
Catatonia 9.83 9.27 12 314192 8744 79421440
Vulvovaginal erythema 9.83 9.27 8 314196 239 79429945
Dyshidrotic eczema 9.81 9.27 12 314192 591 79429593
Wheelchair user 9.80 9.27 6 314198 6126 79424058
Dermatosis 9.79 9.27 12 314192 592 79429592
Lactic acidosis 9.78 9.27 354 313850 70005 79360179
Hospice care 9.75 9.27 16 314188 10308 79419876
Polyomavirus-associated nephropathy 9.73 9.27 5 314199 5622 79424562
Nephrolithiasis 9.72 9.27 277 313927 53014 79377170
Gastrointestinal tract mucosal discolouration 9.72 9.27 4 314200 30 79430154
Chondrocalcinosis 9.71 9.27 16 314188 1040 79429144
Prostate cancer 9.70 9.27 84 314120 33184 79397000
Toxic epidermal necrolysis 9.65 9.27 237 313967 44344 79385840
Cyst 9.63 9.27 90 314114 13750 79416434
Small intestinal stenosis 9.57 9.27 14 314190 821 79429363
Hepatitis fulminant 9.56 9.27 55 314149 7207 79422977
Pyelonephritis acute 9.54 9.27 48 314156 5975 79424209
Erythema multiforme 9.53 9.27 109 314095 17542 79412642
Prinzmetal angina 9.53 9.27 21 314183 1699 79428485
Haemorrhage foetal 9.50 9.27 3 314201 9 79430175
Cystitis glandularis 9.50 9.27 3 314201 9 79430175
Altered state of consciousness 9.50 9.27 233 313971 43589 79386595
Coeliac disease 9.46 9.27 19 314185 11332 79418852
Herpes simplex test positive 9.45 9.27 10 314194 420 79429764
Muscle swelling 9.44 9.27 14 314190 831 79429353
Blood loss anaemia 9.42 9.27 98 314106 15400 79414784
Enterocolitis 9.42 9.27 93 314111 14419 79415765
Insulin autoimmune syndrome 9.41 9.27 10 314194 422 79429762
Anastomotic ulcer 9.39 9.27 13 314191 724 79429460
Purpura senile 9.37 9.27 11 314193 519 79429665
Gastritis erosive 9.36 9.27 74 314130 10773 79419411
Vitamin B12 increased 9.35 9.27 17 314187 1196 79428988
Walking aid user 9.33 9.27 16 314188 10132 79420052
Hypoosmolar state 9.33 9.27 9 314195 338 79429846
Endophthalmitis 9.33 9.27 7 314197 6421 79423763
Gastrointestinal disorder 9.32 9.27 390 313814 121815 79308369
Rhonchi 9.32 9.27 36 314168 4000 79426184
Pyelonephritis 9.31 9.27 122 314082 20266 79409918
Adverse drug reaction 9.31 9.27 195 314009 66197 79363987
Dysgeusia 9.29 9.27 293 313911 56884 79373300
Arteriovenous fistula site haematoma 9.29 9.27 4 314200 34 79430150
Cushingoid 9.28 9.27 67 314137 9485 79420699

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BC05 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Proton pump inhibitors
ATC A02BD06 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC M01AE52 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
FDA MoA N0000000147 Proton Pump Inhibitors
FDA EPC N0000175525 Proton Pump Inhibitor
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054328 Proton Pump Inhibitors
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:49200 proton pump inhibitors
CHEBI has role CHEBI:49201 anti-ulcer drugs
CHEBI has role CHEBI:50183 P450 inhibitors
CHEBI has role CHEBI:77746 Homo sapiens metabolite
FDA MoA N0000182140 Cytochrome P450 2C19 Inhibitors
CHEBI has role CHEBI:37956 antihistamines
CHEBI has role CHEBI:38623 monoamine oxidase inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Erosive esophagitis indication 40719004
Zollinger-Ellison syndrome indication 53132006 DOID:0050782
Peptic reflux disease indication 57643001
Gastroesophageal reflux disease indication 235595009 DOID:8534
Maintenance of Healing Erosive Esophagitis indication
Osteoarthritis in Patients at High Ulcer Risk indication
Duodenal Ulcer due to H. Pylori indication
Rheumatoid Arthritis in Patient at High Ulcer Risk indication
Prevention of NSAID-Induced Gastric Ulcer indication
Pathological Gastric Hypersecretory Condition indication
Upper gastrointestinal hemorrhage off-label use 37372002
Hepatic failure contraindication 59927004
Osteoporosis contraindication 64859006 DOID:11476
Atrophic gastritis contraindication 84568007 DOID:8929
Fracture of bone contraindication 125605004
Hypomagnesemia contraindication 190855004




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.71 acidic
pKa2 4.44 Basic
pKa3 2.53 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 20MG BASE;375MG VIMOVO HORIZON N022511 April 30, 2010 RX TABLET, DELAYED RELEASE ORAL 9393208 Sept. 3, 2029 RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS REQUIRING NSAID TREATMENT
EQ 20MG BASE;500MG VIMOVO HORIZON N022511 April 30, 2010 RX TABLET, DELAYED RELEASE ORAL 9393208 Sept. 3, 2029 RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS REQUIRING NSAID TREATMENT
EQ 20MG BASE;500MG VIMOVO HORIZON N022511 April 30, 2010 RX TABLET, DELAYED RELEASE ORAL 9220698 March 10, 2031 RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS REQUIRING NSAID TREATMENT
EQ 20MG BASE;375MG VIMOVO HORIZON N022511 April 30, 2010 RX TABLET, DELAYED RELEASE ORAL 8945621 Oct. 17, 2031 RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCERS IN PATIENTS ALSO TAKING LOW DOSE ASPIRIN
EQ 20MG BASE;500MG VIMOVO HORIZON N022511 April 30, 2010 RX TABLET, DELAYED RELEASE ORAL 8945621 Oct. 17, 2031 RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCERS IN PATIENTS ALSO TAKING LOW DOSE ASPIRIN

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium-transporting ATPase Transporter INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4021259 VUID
N0000189434 NUI
D01984 KEGG_DRUG
217087-10-0 SECONDARY_CAS_RN
217087-09-7 SECONDARY_CAS_RN
161796-78-7 SECONDARY_CAS_RN
4019439 VANDF
4021259 VANDF
4021260 VANDF
4025229 VANDF
4032661 VANDF
C0937846 UMLSCUI
CHEBI:50275 CHEBI
CHEBI:7772 CHEBI
1C6 PDB_CHEM_ID
CHEMBL1201320 ChEMBL_ID
DB00736 DRUGBANK_ID
CHEMBL2146133 ChEMBL_ID
CHEMBL1200470 ChEMBL_ID
D064098 MESH_DESCRIPTOR_UI
4594 PUBCHEM_CID
5488 IUPHAR_LIGAND_ID
7766 INN_ID
934714-36-0 SECONDARY_CAS_RN
N3PA6559FT UNII
1294569 RXNORM
19233 MMSL
205449 MMSL
211151 MMSL
232889 MMSL
29630 MMSL
45807 MMSL
5201 MMSL
d00325 MMSL
d04749 MMSL
003476 NDDF
008590 NDDF
008918 NDDF
008919 NDDF
015173 NDDF
129489006 SNOMEDCT_US
25673006 SNOMEDCT_US
317331009 SNOMEDCT_US
387137007 SNOMEDCT_US
396047003 SNOMEDCT_US
426956003 SNOMEDCT_US
725855001 SNOMEDCT_US
C0028978 UMLSCUI
CHEMBL2146140 ChEMBL_ID
DB00338 DRUGBANK_ID
5081 INN_ID
D009853 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Esomeprazole Magnesium HUMAN PRESCRIPTION DRUG LABEL 1 0093-6450 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 28 sections
Esomeprazole Magnesium HUMAN PRESCRIPTION DRUG LABEL 1 0093-6450 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 28 sections
Esomeprazole Magnesium HUMAN PRESCRIPTION DRUG LABEL 1 0093-6450 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 28 sections
Esomeprazole Magnesium HUMAN PRESCRIPTION DRUG LABEL 1 0093-6451 CAPSULE, DELAYED RELEASE 40 mg ORAL ANDA 28 sections
Esomeprazole Magnesium HUMAN PRESCRIPTION DRUG LABEL 1 0093-6451 CAPSULE, DELAYED RELEASE 40 mg ORAL ANDA 28 sections
Esomeprazole Magnesium HUMAN PRESCRIPTION DRUG LABEL 1 0093-6451 CAPSULE, DELAYED RELEASE 40 mg ORAL ANDA 28 sections
good sense esomeprazole magnesium HUMAN OTC DRUG LABEL 1 0113-0651 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
basic care esomeprazole magnesium HUMAN OTC DRUG LABEL 1 0113-0732 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
Good Sense Esomeprazole Magnesium HUMAN OTC DRUG LABEL 1 0113-0898 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
Good Sense Esomeprazole Magnesium HUMAN OTC DRUG LABEL 1 0113-0898 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
Esomeprazole magnesium HUMAN PRESCRIPTION DRUG LABEL 1 0186-0382 CAPSULE, DELAYED RELEASE 20 mg ORAL NDA authorized generic 28 sections
Esomeprazole magnesium HUMAN PRESCRIPTION DRUG LABEL 1 0186-0384 CAPSULE, DELAYED RELEASE 40 mg ORAL NDA authorized generic 28 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4010 GRANULE, DELAYED RELEASE 10 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4010 GRANULE, DELAYED RELEASE 10 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4010 GRANULE, DELAYED RELEASE 10 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4010 GRANULE, DELAYED RELEASE 10 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4020 GRANULE, DELAYED RELEASE 20 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4020 GRANULE, DELAYED RELEASE 20 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4020 GRANULE, DELAYED RELEASE 20 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4020 GRANULE, DELAYED RELEASE 20 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4025 GRANULE, DELAYED RELEASE 2.50 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4025 GRANULE, DELAYED RELEASE 2.50 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4025 GRANULE, DELAYED RELEASE 2.50 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4025 GRANULE, DELAYED RELEASE 2.50 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4040 GRANULE, DELAYED RELEASE 40 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4040 GRANULE, DELAYED RELEASE 40 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4040 GRANULE, DELAYED RELEASE 40 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4040 GRANULE, DELAYED RELEASE 40 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4050 GRANULE, DELAYED RELEASE 5 mg ORAL NDA 27 sections
NEXIUM HUMAN PRESCRIPTION DRUG LABEL 1 0186-4050 GRANULE, DELAYED RELEASE 5 mg ORAL NDA 27 sections