esomeprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antiulcer, benzimidazole derivatives 1055 119141-88-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • esomeprazole magnesium dihydrate
  • esomeprazole
  • (S)-Esomeprazole
  • (S)-Omeprazole
  • (-)-Omeprazole
  • esomeprazole magnesium
  • esomeprazole sodium
  • nexium control
  • esomeprazole magnesium hydrate
  • esomeprazole strontium
The S-isomer of omeprazole.
  • Molecular weight: 345.42
  • Formula: C17H19N3O3S
  • CLOGP: 2.56
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 77.10
  • ALOGS: -2.98
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O
30 mg P
0.50 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 5.79 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 53 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.85 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.03 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.83 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK1,GRK2,GSK3B,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAPK1,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 63
kinase-selectivity-class AXL,BRAF,GRK2,PDK4 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 2001 FDA ASTRAZENECA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Chronic kidney disease 1043.27 9.10 906 216790 49285 90361466
Pemphigus 678.78 9.10 24 217672 326840 90083911
Acute kidney injury 583.31 9.10 1893 215803 318494 90092257
Glossodynia 579.10 9.10 53 217643 321726 90089025
Hand deformity 514.49 9.10 56 217640 296306 90114445
Anti-cyclic citrullinated peptide antibody positive 491.98 9.10 17 217679 236416 90174335
Systemic lupus erythematosus 491.64 9.10 131 217565 361765 90048986
Wound 485.61 9.10 74 217622 302906 90107845
Duodenal ulcer perforation 453.22 9.10 18 217678 221270 90189481
Synovitis 405.27 9.10 143 217553 329609 90081142
Helicobacter infection 388.26 9.10 45 217651 226805 90183946
Folliculitis 383.17 9.10 28 217668 204325 90206426
Renal injury 382.47 9.10 262 217434 9981 90400770
Muscle injury 369.94 9.10 12 217684 176642 90234109
Maternal exposure during pregnancy 361.48 9.10 208 217488 359855 90050896
Rheumatic fever 350.69 9.10 3 217693 153118 90257633
Carotid artery thrombosis 333.44 9.10 230 217466 8862 90401889
Neurologic neglect syndrome 329.64 9.10 226 217470 8621 90402130
Adjustment disorder 321.25 9.10 230 217466 9412 90401339
Personality disorder 315.23 9.10 252 217444 12192 90398559
Pericarditis 313.77 9.10 128 217568 270023 90140728
End stage renal disease 310.05 9.10 215 217481 8356 90402395
Arthropathy 302.48 9.10 261 217435 365981 90044770
Irritable bowel syndrome 291.34 9.10 70 217626 207378 90203373
Hemiplegia 290.68 9.10 269 217427 15891 90394860
Injury 272.45 9.10 69 217627 197280 90213471
Drug ineffective 264.94 9.10 2097 215599 1382201 89028550
Hepatocellular injury 262.90 9.10 336 217360 28622 90382129
Discomfort 259.19 9.10 170 217526 274165 90136586
Coordination abnormal 258.59 9.10 287 217409 21069 90389682
Psoriatic arthropathy 257.40 9.10 113 217583 228222 90182529
Blister 256.23 9.10 147 217549 254851 90155900
Swelling 253.44 9.10 384 217312 418674 89992077
Hyponatraemia 253.33 9.10 801 216895 132737 90278014
Affect lability 252.61 9.10 262 217434 17801 90392950
Hepatic enzyme increased 250.11 9.10 299 217397 360437 90050314
Interstitial lung disease 248.57 9.10 560 217136 75845 90334906
Cholestasis 247.84 9.10 367 217329 35932 90374819
Rheumatoid factor positive 233.13 9.10 62 217634 171588 90239163
Exposure during pregnancy 233.09 9.10 142 217554 238268 90172483
Motor dysfunction 232.10 9.10 258 217438 18972 90391779
Alopecia 230.26 9.10 532 217164 494539 89916212
Type 2 diabetes mellitus 222.18 9.10 105 217591 203139 90207612
Hypomagnesaemia 221.99 9.10 345 217351 35243 90375508
Sensory loss 213.85 9.10 240 217456 17835 90392916
Sensitisation 210.57 9.10 129 217567 4046 90406705
C-reactive protein abnormal 204.28 9.10 31 217665 127398 90283353
Dysphagia 195.35 9.10 654 217042 111624 90299127
Arterial occlusive disease 191.32 9.10 190 217506 12256 90398495
Infusion related reaction 191.20 9.10 451 217245 416329 89994422
Angioedema 187.50 9.10 454 217242 64422 90346329
Breast cancer stage III 187.30 9.10 3 217693 84444 90326307
Contraindicated product administered 187.11 9.10 300 217396 319839 90090912
Lip dry 185.88 9.10 15 217681 100940 90309811
Tubulointerstitial nephritis 185.76 9.10 265 217431 25078 90385673
Blood cholesterol increased 184.40 9.10 138 217558 207874 90202877
Polycystic ovaries 181.80 9.10 132 217564 5522 90405229
Sleep disorder due to general medical condition, insomnia type 181.48 9.10 43 217653 128651 90282100
Liver injury 180.53 9.10 92 217604 170475 90240276
Gangrene 178.68 9.10 186 217510 12690 90398061
Ill-defined disorder 178.08 9.10 112 217584 184779 90225972
Hemiparesis 175.92 9.10 292 217404 31527 90379224
Joint swelling 175.06 9.10 621 217075 502679 89908072
Aphasia 174.35 9.10 344 217352 42468 90368283
Mobility decreased 173.50 9.10 208 217488 250526 90160225
Joint range of motion decreased 167.89 9.10 58 217638 135585 90275166
Impaired healing 167.73 9.10 189 217507 234010 90176741
Eating disorder 161.11 9.10 262 217434 27811 90382940
Ejection fraction 159.48 9.10 96 217600 2915 90407836
Facet joint syndrome 157.55 9.10 24 217672 98365 90312386
Respiratory tract congestion 152.15 9.10 252 217444 27158 90383593
Sinus congestion 146.72 9.10 248 217448 27176 90383575
Gait inability 146.23 9.10 85 217611 146371 90264380
Live birth 144.95 9.10 12 217684 79095 90331656
Treatment failure 144.04 9.10 323 217373 303605 90107146
Peripheral venous disease 142.62 9.10 17 217679 83904 90326847
Renal failure 140.84 9.10 656 217040 130351 90280400
Cardiospasm 140.27 9.10 93 217603 3353 90407398
Hypocalcaemia 139.40 9.10 312 217384 42056 90368695
Palpitations 139.25 9.10 674 217022 136054 90274697
Palmoplantar keratoderma 138.78 9.10 93 217603 3414 90407337
Obesity 137.86 9.10 41 217655 105466 90305285
Stomatitis 133.40 9.10 288 217408 274410 90136341
Lower respiratory tract infection 130.89 9.10 252 217444 250407 90160344
Pruritus genital 129.96 9.10 99 217597 4459 90406292
Prescribed overdose 127.44 9.10 38 217658 97587 90313164
Autoimmune disorder 124.53 9.10 18 217678 76726 90334025
Wound infection 124.11 9.10 50 217646 106352 90304399
Lower limb fracture 120.65 9.10 28 217668 84985 90325766
Inappropriate antidiuretic hormone secretion 120.11 9.10 188 217508 19317 90391434
Atrial tachycardia 120.09 9.10 106 217590 5884 90404867
Multi-organ disorder 118.75 9.10 71 217625 2129 90408622
Dysarthria 118.46 9.10 343 217353 54139 90356612
Muscle spasticity 117.20 9.10 261 217435 35061 90375690
Sneezing 116.81 9.10 236 217460 29633 90381118
Angina pectoris 116.31 9.10 277 217419 38883 90371868
Grip strength decreased 115.56 9.10 39 217657 92537 90318214
Loss of employment 115.30 9.10 78 217618 2909 90407842
Blepharospasm 115.20 9.10 4 217692 55441 90355310
Sleep terror 114.34 9.10 91 217605 4373 90406378
Sleep apnoea syndrome 111.48 9.10 240 217456 31507 90379244
Cough 110.46 9.10 1363 216333 367599 90043152
Dislocation of vertebra 109.82 9.10 6 217690 55962 90354789
Rash maculo-papular 109.34 9.10 278 217418 40655 90370096
Drug reaction with eosinophilia and systemic symptoms 107.64 9.10 284 217412 42474 90368277
Hypertensive nephropathy 105.99 9.10 45 217651 633 90410118
Systemic lupus erythematosus rash 105.86 9.10 68 217628 2321 90408430
Therapeutic product effect decreased 104.91 9.10 330 217366 277241 90133510
Carotid artery occlusion 103.42 9.10 100 217596 6242 90404509
Skin haemorrhage 102.21 9.10 184 217512 21196 90389555
Completed suicide 101.71 9.10 119 217577 144939 90265812
Hypercholesterolaemia 101.49 9.10 58 217638 100834 90309917
Agranulocytosis 101.17 9.10 245 217451 34757 90375994
Sinus disorder 100.51 9.10 242 217454 34205 90376546
Tension headache 98.02 9.10 105 217591 7404 90403347
Knee arthroplasty 97.15 9.10 39 217657 83143 90327608
General physical health deterioration 96.19 9.10 482 217214 354633 90056118
Rheumatoid nodule 95.70 9.10 173 217523 19993 90390758
Immunisation 95.62 9.10 62 217634 2151 90408600
X-ray abnormal 95.36 9.10 3 217693 45421 90365330
Lupus vulgaris 94.50 9.10 3 217693 45056 90365695
Human rhinovirus test positive 93.63 9.10 45 217651 858 90409893
Rhinitis allergic 92.73 9.10 154 217542 16631 90394120
Respiratory syncytial virus test positive 92.67 9.10 47 217649 1011 90409740
Dysphonia 92.12 9.10 347 217349 62737 90348014
Eosinophilia 89.28 9.10 206 217490 28327 90382424
Pregnancy 88.91 9.10 20 217676 62027 90348724
Night sweats 88.82 9.10 107 217589 128659 90282092
Abdominal discomfort 87.84 9.10 729 216967 476599 89934152
Renal disorder 87.81 9.10 244 217452 37615 90373136
Nephrectomy 86.83 9.10 56 217640 1925 90408826
Off label use 86.74 9.10 2003 215693 1100249 89310502
Drug interaction 86.48 9.10 1030 216666 275423 90135328
Swollen tongue 86.46 9.10 275 217421 45681 90365070
Sciatica 86.33 9.10 70 217626 101312 90309439
Road traffic accident 85.94 9.10 79 217617 107547 90303204
Bone erosion 84.72 9.10 13 217683 53008 90357743
Nail disorder 84.72 9.10 19 217677 59048 90351703
Fall 82.64 9.10 1620 216076 480190 89930561
Toxic skin eruption 82.20 9.10 141 217555 15633 90395118
Epigastric discomfort 80.29 9.10 95 217601 7473 90403278
Hip arthroplasty 79.27 9.10 42 217654 76166 90334585
Hypokalaemia 79.12 9.10 563 217133 130553 90280198
Rhinorrhoea 79.10 9.10 420 217276 87896 90322855
Coeliac disease 78.42 9.10 8 217688 44602 90366149
Ulcer 78.33 9.10 214 217482 32668 90378083
Blood test abnormal 77.74 9.10 162 217534 20790 90389961
Therapy non-responder 77.08 9.10 131 217565 136573 90274178
Pleural fibrosis 76.86 9.10 66 217630 3530 90407221
Product use in unapproved indication 76.07 9.10 484 217212 335752 90074999
Sleep disorder 75.81 9.10 234 217462 197796 90212955
Presbyacusis 75.76 9.10 61 217635 2981 90407770
Anosmia 75.16 9.10 105 217591 9743 90401008
Carpal tunnel syndrome 75.14 9.10 173 217523 23755 90386996
Nephropathy 74.29 9.10 101 217595 9134 90401617
Anaemia 74.15 9.10 1225 216471 351577 90059174
Viral test positive 72.66 9.10 34 217662 609 90410142
Contusion 72.64 9.10 333 217363 250883 90159868
Hypothyroidism 71.66 9.10 285 217411 52842 90357909
Impaired work ability 71.21 9.10 149 217547 19177 90391574
Condition aggravated 71.13 9.10 1005 216691 594540 89816211
Cataract 70.94 9.10 352 217344 71740 90339011
Ejection fraction abnormal 70.79 9.10 54 217642 2437 90408314
Malnutrition 70.63 9.10 145 217551 18413 90392338
Tinnitus 70.48 9.10 246 217450 42856 90367895
Subarachnoid haemorrhage 69.45 9.10 141 217555 17763 90392988
Nasal turbinate hypertrophy 69.44 9.10 37 217659 884 90409867
Bronchial neoplasm 69.24 9.10 31 217665 499 90410252
Diplopia 68.52 9.10 187 217509 28527 90382224
Pleural thickening 68.18 9.10 59 217637 3189 90407562
Urticaria 67.78 9.10 456 217240 312278 90098473
Onychomadesis 67.59 9.10 14 217682 45984 90364767
Physical deconditioning 66.95 9.10 50 217646 2185 90408566
Diarrhoea 66.91 9.10 2824 214872 936366 89474385
Liver function test increased 66.90 9.10 63 217633 84792 90325959
Drug intolerance 66.75 9.10 720 216976 446871 89963880
Weight increased 66.10 9.10 663 217033 417264 89993487
Taste disorder 65.38 9.10 33 217663 61513 90349238
Pneumonia haemophilus 64.68 9.10 42 217654 1461 90409290
Hyperkalaemia 64.49 9.10 318 217378 64646 90346105
Infection 64.32 9.10 558 217138 361536 90049215
Swelling face 64.27 9.10 374 217322 80978 90329773
Tenosynovitis stenosans 63.83 9.10 62 217634 3891 90406860
Product use issue 63.80 9.10 497 217199 329422 90081329
Renal impairment 63.79 9.10 453 217243 104968 90305783
Death 63.51 9.10 746 216950 455805 89954946
Acute generalised exanthematous pustulosis 61.79 9.10 115 217581 13588 90397163
Hypoaesthesia 61.38 9.10 472 217224 313738 90097013
Cardiac failure 60.25 9.10 460 217236 109036 90301715
Bronchial haemorrhage 60.10 9.10 30 217666 623 90410128
Blood magnesium increased 59.87 9.10 56 217640 3352 90407399
Walking aid user 58.37 9.10 8 217688 35498 90375253
Facial pain 57.42 9.10 109 217587 13073 90397678
Drug eruption 56.95 9.10 201 217495 35206 90375545
Rebound acid hypersecretion 56.63 9.10 24 217672 336 90410415
Nephrogenic anaemia 56.28 9.10 47 217649 2419 90408332
Cystitis 56.17 9.10 312 217384 66406 90344345
Cross sensitivity reaction 56.16 9.10 50 217646 2807 90407944
Intentional product use issue 54.42 9.10 302 217394 216590 90194161
Dry eye 54.28 9.10 279 217417 57652 90353099
Ventricular tachycardia 54.13 9.10 156 217540 24552 90386199
Bronchial disorder 54 9.10 38 217658 1512 90409239
Finger deformity 52.71 9.10 8 217688 32889 90377862
Bursitis 52.22 9.10 153 217543 131501 90279250
Arthritis 52.10 9.10 623 217073 166692 90244059
Eye haemorrhage 51.74 9.10 90 217606 10090 90400661
Disturbance in attention 51.40 9.10 237 217459 46872 90363879
Vasculitis 51.39 9.10 145 217551 22548 90388203
Cerebrovascular accident 51.09 9.10 487 217209 123046 90287705
Rhabdomyolysis 50.94 9.10 251 217445 51005 90359746
Hiatus hernia 50.69 9.10 155 217541 25206 90385545
Pancreatitis acute 50.53 9.10 181 217515 31934 90378817
Diabetic nephropathy 50.18 9.10 38 217658 1696 90409055
Crepitations 49.95 9.10 82 217614 8770 90401981
Endometrial ablation 49.88 9.10 31 217665 998 90409753
Chest discomfort 49.78 9.10 530 217166 137835 90272916
Device expulsion 49.68 9.10 18 217678 40868 90369883
Pain 49.64 9.10 1925 215771 994416 89416335
Back injury 49.52 9.10 25 217671 46597 90364154
Deafness neurosensory 49.34 9.10 71 217625 6770 90403981
Lupus-like syndrome 49.23 9.10 28 217668 48818 90361933
Musculoskeletal stiffness 48.71 9.10 466 217230 296066 90114685
Iron deficiency anaemia 48.59 9.10 146 217550 23516 90387235
Gastritis 48.51 9.10 214 217482 41539 90369212
Gastric polyps 48.49 9.10 58 217638 4614 90406137
Onychomycosis 47.95 9.10 15 217681 37361 90373390
Thyroid disorder 47.71 9.10 121 217575 17664 90393087
Synovial fluid analysis 47.02 9.10 45 217651 2773 90407978
Subacute cutaneous lupus erythematosus 46.60 9.10 50 217646 3532 90407219
Electric shock 46.03 9.10 36 217660 1686 90409065
Prescription form tampering 45.96 9.10 26 217670 701 90410050
Blindness 44.62 9.10 153 217543 26415 90384336
Dermatitis bullous 44.56 9.10 85 217611 10231 90400520
Influenza like illness 44.53 9.10 339 217357 80272 90330479
Hepatic cytolysis 44.25 9.10 169 217527 30747 90380004
Cell death 43.95 9.10 45 217651 3010 90407741
Muscular weakness 43.51 9.10 718 216978 205948 90204803
Laryngitis 43.25 9.10 35 217661 50718 90360033
Anal abscess 42.29 9.10 60 217636 5648 90405103
Osteosclerosis 42.19 9.10 52 217644 4268 90406483
Headache 42.17 9.10 2502 215194 860244 89550507
Phlebitis 42.16 9.10 69 217627 7361 90403390
Lactic acidosis 41.82 9.10 235 217461 50228 90360523
Skin exfoliation 41.76 9.10 293 217403 67620 90343131
Mouth haemorrhage 41.71 9.10 74 217622 8427 90402324
Kidney infection 41.58 9.10 147 217549 25769 90384982
Hepatic function abnormal 41.35 9.10 220 217476 46068 90364683
Hypersensitivity 41.16 9.10 807 216889 453870 89956881
Fibromyalgia 41.13 9.10 308 217388 205961 90204790
Nausea 41.01 9.10 3145 214551 1107171 89303580
Toxicity to various agents 40.89 9.10 468 217228 287378 90123373
Gamma-glutamyltransferase increased 40.72 9.10 190 217506 37762 90372989
Axonal neuropathy 40.64 9.10 29 217667 1180 90409571
Urate nephropathy 40.63 9.10 15 217681 142 90410609
Breath sounds abnormal 40.57 9.10 104 217592 15282 90395469
Scleritis 40.45 9.10 56 217640 5152 90405599
Mast cell activation syndrome 39.77 9.10 32 217664 1562 90409189
Macular degeneration 39.38 9.10 21 217675 37949 90372802
Transient ischaemic attack 39.11 9.10 206 217490 42970 90367781
Hallucination 39.06 9.10 282 217414 65677 90345074
Oedema 39.03 9.10 301 217395 199994 90210757
Dehydration 38.90 9.10 670 217026 193777 90216974
Nerve injury 37.89 9.10 83 217613 11023 90399728
Bone cyst 37.84 9.10 37 217659 2341 90408410
Blood pressure increased 37.82 9.10 675 217021 196542 90214209
Pain of skin 37.64 9.10 104 217592 15978 90394773
Myelosuppression 37.51 9.10 44 217652 53547 90357204
Skin ulcer 37.48 9.10 227 217469 49848 90360903
Tongue biting 37.38 9.10 35 217661 2098 90408653
Fatigue 36.69 9.10 2336 215360 1151687 89259064
Anti-cyclic citrullinated peptide antibody 36.62 9.10 10 217686 27211 90383540
Gastric disorder 36.45 9.10 168 217528 33216 90377535
Burning sensation 36.27 9.10 269 217427 63183 90347568
Disability 36.11 9.10 27 217669 40718 90370033
Rash 35.76 9.10 1556 216140 794544 89616207
Lymphatic fistula 35.75 9.10 29 217667 1432 90409319
Malaise 35.68 9.10 1735 215961 584251 89826500
Anxiety 35.50 9.10 985 216711 308787 90101964
Osteoarthritis 35.44 9.10 300 217396 195430 90215321
Occupational asthma 35.04 9.10 14 217682 167 90410584
Femoral hernia incarcerated 34.95 9.10 29 217667 1479 90409272
Pericardial effusion 34.93 9.10 178 217518 36655 90374096
Abdominal pain upper 34.87 9.10 1046 216650 331628 90079123
Rash papular 34.87 9.10 118 217578 20237 90390514
Immunodeficiency 34.19 9.10 32 217664 43202 90367549
Pulmonary fibrosis 33.79 9.10 138 217558 107365 90303386
Musculoskeletal pain 33.52 9.10 257 217439 170994 90239757
Erythema dyschromicum perstans 33.45 9.10 11 217685 71 90410680
Product quality issue 33.06 9.10 90 217606 79235 90331516
Synovial cyst 32.62 9.10 81 217615 11671 90399080
Nephritic syndrome 32.53 9.10 17 217679 390 90410361
Anaemia macrocytic 32.32 9.10 47 217649 4525 90406226
Osteopenia 32.31 9.10 125 217571 22877 90387874
Abortion spontaneous 32.15 9.10 50 217646 54006 90356745
Drug tolerance 32.05 9.10 3 217693 17913 90392838
Adverse event 31.95 9.10 159 217537 117259 90293492
Angina bullosa haemorrhagica 31.83 9.10 12 217684 121 90410630
Post cholecystectomy syndrome 31.63 9.10 22 217674 859 90409892
Erythema 31.54 9.10 747 216949 228499 90182252
Lip swelling 31.46 9.10 179 217517 38431 90372320
Intervertebral discitis 31.28 9.10 46 217650 4474 90406277
Hepatic steatosis 31.24 9.10 173 217523 36772 90373979
Bunion operation 31.23 9.10 26 217670 1332 90409419
Influenza 31.23 9.10 489 217207 138775 90271976
Gastrointestinal motility disorder 31.15 9.10 54 217642 6037 90404714
No adverse event 30.74 9.10 74 217622 67908 90342843
Arterial haemorrhage 30.70 9.10 34 217662 2489 90408262
Normal newborn 30.65 9.10 9 217687 23353 90387398
Nasal discharge discolouration 30.57 9.10 36 217660 2817 90407934
Anaphylactic reaction 29.96 9.10 332 217364 87192 90323559
Nasopharyngitis 29.82 9.10 747 216949 406357 90004394
Amniotic fluid index increased 29.81 9.10 11 217685 104 90410647
Neurosis 29.78 9.10 16 217680 389 90410362
Gallbladder polyp 29.70 9.10 22 217674 949 90409802
Diverticulum intestinal 29.70 9.10 67 217629 9075 90401676
Infusion site reaction 29.67 9.10 5 217691 19034 90391717
Food allergy 29.66 9.10 12 217684 25466 90385285
Cardiac disorder 29.65 9.10 236 217460 56636 90354115
Adverse drug reaction 29.52 9.10 162 217534 116539 90294212
Wound infection pseudomonas 29.47 9.10 30 217666 1993 90408758
Anaemia vitamin B12 deficiency 29.46 9.10 19 217677 653 90410098
Mesenteric panniculitis 29.17 9.10 13 217683 207 90410544
Tenosynovitis 29.08 9.10 89 217607 14478 90396273
Pancreatic steatosis 28.88 9.10 27 217669 1615 90409136
Urinary retention 28.82 9.10 172 217524 37572 90373179
Electrocardiogram QT prolonged 28.65 9.10 283 217413 72173 90338578
Photophobia 28.60 9.10 114 217582 21155 90389596
Cholestatic liver injury 28.26 9.10 40 217656 3757 90406994
Hunger 28.25 9.10 54 217642 6509 90404242
Wheezing 28.25 9.10 402 217294 237678 90173073
Face oedema 28.22 9.10 121 217575 23197 90387554
Nephrosclerosis 28.18 9.10 23 217673 1146 90409605
Peripheral swelling 28.15 9.10 766 216930 412340 89998411
Rhinitis 28.11 9.10 84 217612 13488 90397263
Seronegative arthritis 27.95 9.10 5 217691 18229 90392522
Memory impairment 27.87 9.10 321 217375 196923 90213828
Septic shock 27.79 9.10 317 217379 83843 90326908
Aspartate aminotransferase 27.68 9.10 19 217677 726 90410025
Flatulence 27.53 9.10 182 217514 41185 90369566
Eye pruritus 27.33 9.10 140 217556 28887 90381864
Cerebral haematoma 27.33 9.10 42 217654 4247 90406504
Vertigo 27.28 9.10 272 217424 69539 90341212
Foetal death 27.16 9.10 8 217688 20715 90390036
Febrile bone marrow aplasia 26.90 9.10 67 217629 9671 90401080
Ulcer haemorrhage 26.65 9.10 15 217681 26306 90384445
Pustular psoriasis 26.54 9.10 6 217690 18550 90392201
Cutaneous lupus erythematosus 26.46 9.10 35 217661 3083 90407668
Altered state of consciousness 26.23 9.10 147 217549 31385 90379366
Lip oedema 26.21 9.10 43 217653 4596 90406155
Rhonchi 26.15 9.10 34 217662 2944 90407807
Eructation 26.09 9.10 71 217625 10811 90399940
Pancreatic neuroendocrine tumour 25.83 9.10 17 217679 605 90410146
Oesophageal dilatation 25.80 9.10 16 217680 513 90410238
Allergy to chemicals 25.68 9.10 38 217658 3716 90407035
Acute hepatitis B 25.52 9.10 14 217682 355 90410396
Vitreous detachment 25.47 9.10 30 217666 2348 90408403
Dermatitis exfoliative generalised 25.30 9.10 47 217649 5546 90405205
Skin lesion 25.23 9.10 165 217531 37200 90373551
Pulmonary arterial hypertension 25.14 9.10 127 217569 26060 90384691
Drug resistance 24.72 9.10 22 217674 30427 90380324
Anuria 24.59 9.10 85 217611 14733 90396018
Hypergastrinaemia 24.19 9.10 10 217686 131 90410620
Delirium 24.19 9.10 149 217547 104210 90306541
Renal tubular disorder 24.19 9.10 34 217662 3173 90407578
Pulmonary haemorrhage neonatal 24.15 9.10 8 217688 53 90410698
Eosinophilic fasciitis 23.97 9.10 11 217685 188 90410563
Deformity 23.97 9.10 74 217622 12096 90398655
Seroma 23.91 9.10 33 217663 3027 90407724
Conjunctivitis 23.90 9.10 127 217569 26579 90384172
Gastrointestinal haemorrhage 23.82 9.10 326 217370 89922 90320829
Pulmonary congestion 23.64 9.10 101 217595 19332 90391419
Nasal congestion 23.54 9.10 305 217391 83109 90327642
Schizophreniform disorder 23.51 9.10 9 217687 95 90410656
Abdominal pain 23.28 9.10 1168 216528 394553 90016198
Cyst 23.27 9.10 90 217606 16471 90394280
Blood parathyroid hormone decreased 22.88 9.10 73 217623 12143 90398608
Inflammation 22.82 9.10 297 217399 178295 90232456
Hepatitis cholestatic 22.71 9.10 58 217638 8503 90402248
Haemoglobin decreased 22.65 9.10 529 217167 161427 90249324
Eyelid oedema 22.59 9.10 70 217626 11464 90399287
Haemarthrosis 22.54 9.10 37 217659 3957 90406794
Blood immunoglobulin A increased 22.38 9.10 21 217675 1262 90409489
Hypoosmolar state 22.32 9.10 11 217685 222 90410529
Ear infection 22.28 9.10 89 217607 69686 90341065
Muscle twitching 22.28 9.10 116 217580 24086 90386665
Throat irritation 22.16 9.10 196 217500 48499 90362252
Vascular purpura 22.15 9.10 24 217672 1714 90409037
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 22.02 9.10 8 217688 72 90410679
Clinically isolated syndrome 21.86 9.10 7 217689 41 90410710
Tooth infection 21.65 9.10 101 217595 20069 90390682
Tongue injury 21.65 9.10 15 217681 582 90410169
Gastric antral vascular ectasia 21.45 9.10 17 217679 812 90409939
Nephritis allergic 21.40 9.10 12 217684 318 90410433
Glossitis 21.29 9.10 34 217662 3553 90407198
Cushingoid 21.21 9.10 64 217632 10331 90400420
Vitamin B12 increased 21.18 9.10 24 217672 1802 90408949
Small cell carcinoma 21.18 9.10 10 217686 183 90410568
Salpingo-oophorectomy unilateral 21.16 9.10 18 217678 950 90409801
Vulvovaginal inflammation 21.16 9.10 19 217677 1079 90409672
Eczema 21.14 9.10 207 217489 52663 90358088
Hepatic encephalopathy 21.14 9.10 77 217619 13695 90397056
Supraventricular extrasystoles 21.10 9.10 42 217654 5215 90405536
Premature delivery 21.06 9.10 38 217658 38724 90372027
Hypocapnia 21.06 9.10 14 217682 507 90410244
Granulocyte count increased 21.00 9.10 22 217674 1512 90409239
Psychomotor skills impaired 21.00 9.10 30 217666 2842 90407909
Gait disturbance 20.99 9.10 471 217225 260025 90150726
Enterocolitis 20.86 9.10 64 217632 10426 90400325
Epilepsy 20.85 9.10 114 217582 82092 90328659
Therapy interrupted 20.77 9.10 57 217639 50051 90360700
Paranasal sinus inflammation 20.73 9.10 15 217681 624 90410127
Treatment noncompliance 20.58 9.10 60 217636 51667 90359084
Adenocarcinoma gastric 20.52 9.10 15 217681 634 90410117
Dry skin 20.41 9.10 311 217385 87762 90322989
Vulvovaginal burning sensation 20.30 9.10 28 217668 2567 90408184
Blood loss anaemia 20.29 9.10 62 217634 10078 90400673
Muscle haemorrhage 20.25 9.10 32 217664 3314 90407437
Red blood cell sedimentation rate abnormal 20.24 9.10 17 217679 24187 90386564
Prescribed underdose 20.17 9.10 102 217594 74917 90335834
Melaena 20.15 9.10 148 217548 34649 90376102
Vitamin B12 deficiency 20.15 9.10 51 217645 7435 90403316
Erythema multiforme 20.11 9.10 70 217626 12176 90398575
Hepatitis B DNA increased 20.05 9.10 11 217685 279 90410472
Rectosigmoid cancer 19.93 9.10 10 217686 210 90410541
Alanine aminotransferase increased 19.91 9.10 397 217299 117941 90292810
Catarrh 19.85 9.10 22 217674 1612 90409139
Aortic valve stenosis 19.64 9.10 36 217660 4204 90406547
Atrioventricular block complete 19.64 9.10 60 217636 9751 90401000
Joint destruction 19.61 9.10 4 217692 13283 90397468
Burns second degree 19.60 9.10 24 217672 1956 90408795
Ingrowing nail 19.58 9.10 29 217667 2838 90407913
Medication error 19.55 9.10 121 217575 84531 90326220
Congenital osteodystrophy 19.53 9.10 6 217690 30 90410721
Exostosis 19.46 9.10 64 217632 53070 90357681
Renal atrophy 19.28 9.10 23 217673 1825 90408926
Jaundice 19.23 9.10 139 217557 32378 90378373
Incorrect route of product administration 19.23 9.10 60 217636 50566 90360185
Pneumobilia 19.19 9.10 9 217687 162 90410589
Disease progression 19.08 9.10 263 217433 156352 90254399
Genital infection female 19.07 9.10 8 217688 109 90410642
Tenderness 18.97 9.10 120 217576 26748 90384003
Sputum increased 18.90 9.10 29 217667 2928 90407823
Simple partial seizures 18.86 9.10 15 217681 720 90410031
Glomerular filtration rate increased 18.85 9.10 24 217672 2036 90408715
Erdheim-Chester disease 18.80 9.10 7 217689 68 90410683
Thymus disorder 18.73 9.10 11 217685 319 90410432
Injection site erythema 18.72 9.10 149 217547 98353 90312398
Hepatocellular carcinoma 18.70 9.10 26 217670 2402 90408349
Myalgia 18.69 9.10 552 217144 174573 90236178
Eye pain 18.69 9.10 175 217521 43993 90366758
Drug hypersensitivity 18.57 9.10 917 216779 462692 89948059
Foetal macrosomia 18.47 9.10 10 217686 247 90410504
Gastric ulcer 18.41 9.10 121 217575 27327 90383424
Escherichia pyelonephritis 18.38 9.10 15 217681 747 90410004
Sedation 18.36 9.10 57 217639 48114 90362637
Hyperuricaemia 18.32 9.10 46 217650 6673 90404078
Pleuritic pain 18.23 9.10 61 217635 10400 90400351
Aspartate aminotransferase increased 18.22 9.10 348 217348 102589 90308162
Sedation complication 18.12 9.10 9 217687 16935 90393816
Crystal arthropathy 18.10 9.10 11 217685 340 90410411
Depression 18.05 9.10 567 217129 300034 90110717
Genotype drug resistance test positive 17.99 9.10 12 217684 437 90410314
Myocardial infarction 17.99 9.10 356 217340 105616 90305135
Hepatic cyst 17.94 9.10 45 217651 6523 90404228
Major depression 17.92 9.10 59 217637 9976 90400775
Gastric adenoma 17.90 9.10 4 217692 3 90410748
Product substitution issue 17.76 9.10 88 217608 17920 90392831
Quadriparesis 17.72 9.10 26 217670 2523 90408228
Eye irritation 17.71 9.10 141 217555 33837 90376914
Proteinuria 17.69 9.10 106 217590 23185 90387566
Blood alkaline phosphatase increased 17.67 9.10 185 217511 47894 90362857
Female sterilisation 17.66 9.10 14 217682 669 90410082
Metabolic acidosis 17.62 9.10 208 217488 55468 90355283
Left-to-right cardiac shunt 17.60 9.10 10 217686 272 90410479
Non-economic loss 17.58 9.10 5 217691 18 90410733
Shock haemorrhagic 17.57 9.10 67 217629 12178 90398573
Faecaloma 17.45 9.10 60 217636 10371 90400380
Tetany 17.45 9.10 26 217670 2558 90408193
Cholecystitis acute 17.43 9.10 56 217640 9348 90401403
COVID-19 17.42 9.10 530 217166 168313 90242438
Congenital tricuspid valve incompetence 17.27 9.10 8 217688 140 90410611
Bradypnoea 17.26 9.10 36 217660 4622 90406129
IIIrd nerve paresis 17.21 9.10 8 217688 141 90410610
Antinuclear antibody positive 17.10 9.10 55 217641 9186 90401565
Wound dehiscence 17.09 9.10 41 217655 5781 90404970
Muscle swelling 17.03 9.10 13 217683 587 90410164
Purple glove syndrome 16.97 9.10 9 217687 213 90410538
Seizure 16.96 9.10 261 217435 152368 90258383
Syncope 16.95 9.10 428 217268 132235 90278516
General symptom 16.92 9.10 7 217689 14661 90396090
Caesarean section 16.87 9.10 12 217684 18565 90392186
Spinal disorder 16.84 9.10 64 217632 11615 90399136
Post-traumatic stress disorder 16.82 9.10 45 217651 6783 90403968
Hyperchlorhydria 16.80 9.10 22 217674 1919 90408832
Cerebellar haematoma 16.78 9.10 11 217685 389 90410362
Tooth disorder 16.75 9.10 130 217566 30960 90379791
Purging 16.72 9.10 6 217690 52 90410699
Thrombocytopenia 16.69 9.10 636 217060 208089 90202662
Organising pneumonia 16.67 9.10 48 217648 7549 90403202
Hyponatraemic seizure 16.61 9.10 12 217684 498 90410253
Oxygen saturation decreased 16.58 9.10 356 217340 107127 90303624
Mixed liver injury 16.57 9.10 48 217648 7575 90403176
Rhinalgia 16.53 9.10 25 217671 2493 90408258
Hypercapnia 16.45 9.10 44 217652 6633 90404118
Red blood cell count decreased 16.40 9.10 177 217519 46174 90364577
Muscle contractions involuntary 16.35 9.10 27 217669 2901 90407850
Neonatal hypotension 16.30 9.10 8 217688 160 90410591
Pulmonary hypertension 16.28 9.10 165 217531 42358 90368393
Aplastic anaemia 16.17 9.10 69 217627 13200 90397551
Heart rate increased 16.16 9.10 370 217326 112532 90298219
Procedural pain 16.15 9.10 35 217661 33325 90377426
Creatinine renal clearance decreased 16.14 9.10 13 217683 18886 90391865
Hypopnoea 16.13 9.10 34 217662 4397 90406354
Vitamin D deficiency 16.06 9.10 84 217612 17472 90393279
Cognitive disorder 16.05 9.10 245 217451 69162 90341589
Blood creatinine increased 16.02 9.10 337 217359 101049 90309702
Affective disorder 15.92 9.10 48 217648 7745 90403006
Hypofibrinogenaemia 15.88 9.10 18 217678 1352 90409399
Cardiac failure chronic 15.76 9.10 39 217657 5607 90405144
Blood pressure systolic abnormal 15.67 9.10 90 217606 19388 90391363
Arterial spasm 15.62 9.10 6 217690 64 90410687
Flank pain 15.58 9.10 89 217607 19133 90391618
Tongue oedema 15.57 9.10 38 217658 5416 90405335
Lymphocele 15.56 9.10 14 217682 797 90409954
Sensitivity to weather change 15.55 9.10 52 217644 8862 90401889
Infusion site thrombosis 15.53 9.10 8 217688 178 90410573
Blood pressure diastolic decreased 15.48 9.10 114 217582 26712 90384039
Campylobacter gastroenteritis 15.30 9.10 14 217682 815 90409936
Hyperthermia 15.21 9.10 57 217639 10278 90400473
Joint effusion 15.16 9.10 90 217606 19620 90391131
Extremity necrosis 15.13 9.10 21 217675 1936 90408815
Odynophagia 15.12 9.10 52 217644 8991 90401760
Sinusitis fungal 15.08 9.10 21 217675 1943 90408808
Haematuria 15.07 9.10 139 217557 34798 90375953
Congenital bowing of long bones 15.06 9.10 6 217690 71 90410680
Obstructive airways disorder 14.97 9.10 110 217586 25759 90384992
Vulvovaginal pruritus 14.96 9.10 31 217665 3962 90406789
Renal haemangioma 14.86 9.10 5 217691 35 90410716
Sinus bradycardia 14.75 9.10 80 217616 16872 90393879
Blood thyroid stimulating hormone increased 14.75 9.10 52 217644 9103 90401648
Rectal cancer metastatic 14.73 9.10 9 217687 281 90410470
Dental restoration failure 14.71 9.10 16 217680 1148 90409603
Haematoma 14.70 9.10 151 217545 38897 90371854
Product complaint 14.70 9.10 7 217689 13493 90397258
Pyelonephritis acute 14.61 9.10 37 217659 5395 90405356
Acute coronary syndrome 14.57 9.10 58 217638 10755 90399996
Rheumatoid factor increased 14.51 9.10 23 217673 2388 90408363
Deja vu 14.49 9.10 7 217689 135 90410616
Premature labour 14.46 9.10 7 217689 13369 90397382
Hyperhidrosis 14.37 9.10 429 217267 135876 90274875
Epiglottic erythema 14.35 9.10 6 217690 81 90410670
Livedo reticularis 14.33 9.10 28 217668 3431 90407320
Campylobacter colitis 14.28 9.10 5 217691 40 90410711
Laboratory test abnormal 14.26 9.10 52 217644 41802 90368949
Language disorder 14.21 9.10 24 217672 2628 90408123
Dry mouth 14.20 9.10 335 217361 183724 90227027
Accidental exposure to product 14.20 9.10 53 217643 42313 90368438
Chondrocalcinosis pyrophosphate 14.17 9.10 15 217681 1043 90409708
Granuloma skin 14.16 9.10 57 217639 10623 90400128
Retinal artery occlusion 14.14 9.10 22 217674 2249 90408502
Liver abscess 14.12 9.10 28 217668 3468 90407283
Antipsychotic drug level above therapeutic 14.07 9.10 17 217679 1367 90409384
Asthmatic crisis 14.03 9.10 20 217676 1890 90408861
Enterocolitis haemorrhagic 14.02 9.10 19 217677 1713 90409038
Bladder sphincter atony 14 9.10 8 217688 220 90410531
Cardiac failure congestive 13.99 9.10 323 217373 98371 90312380
Brucellosis 13.91 9.10 6 217690 88 90410663
Atrophy 13.91 9.10 21 217675 2091 90408660
Synovial disorder 13.85 9.10 26 217670 3092 90407659
Temperature regulation disorder 13.79 9.10 9 217687 14570 90396181
Device dependence 13.74 9.10 4 217692 16 90410735
Dysuria 13.73 9.10 150 217546 39251 90371500
Purpura 13.72 9.10 71 217625 14707 90396044
Blood pressure fluctuation 13.69 9.10 189 217507 52224 90358527
Malabsorption 13.65 9.10 35 217661 5143 90405608
Respiratory symptom 13.63 9.10 31 217665 4221 90406530
Blood potassium increased 13.63 9.10 91 217605 20658 90390093
Overdose 13.61 9.10 282 217414 157427 90253324
Ear pain 13.57 9.10 82 217614 57620 90353131
Tachycardia paroxysmal 13.56 9.10 9 217687 325 90410426
Hypertensive crisis 13.55 9.10 81 217615 17703 90393048
Lordosis 13.54 9.10 9 217687 326 90410425
Granuloma 13.50 9.10 39 217657 6146 90404605
Hyperparathyroidism secondary 13.44 9.10 19 217677 1782 90408969
Renal hypertrophy 13.39 9.10 5 217691 49 90410702
Hyperlipasaemia 13.36 9.10 13 217683 818 90409933
Aphthous ulcer 13.34 9.10 79 217617 17208 90393543
Meningitis aseptic 13.17 9.10 41 217655 6732 90404019
Epiglottic oedema 13.11 9.10 7 217689 168 90410583
Underdose 13.11 9.10 76 217620 53941 90356810
Gastrooesophageal reflux disease 13.09 9.10 506 217190 165831 90244920
Polyglandular autoimmune syndrome type II 13.04 9.10 5 217691 53 90410698
Groin pain 12.99 9.10 61 217635 12152 90398599
Gastroenteritis 12.97 9.10 117 217579 29112 90381639
Blood magnesium decreased 12.95 9.10 73 217623 15620 90395131
Miosis 12.88 9.10 51 217645 9433 90401318
Pleurisy 12.87 9.10 50 217646 9167 90401584
Hyperphosphatasaemia 12.86 9.10 4 217692 21 90410730
Metastases to lymph nodes 12.82 9.10 6 217690 11683 90399068
Keratoacanthoma 12.81 9.10 11 217685 588 90410163
Carnitine deficiency 12.78 9.10 7 217689 177 90410574
Stent placement 12.77 9.10 30 217666 4173 90406578
Blood pressure systolic increased 12.74 9.10 204 217492 58141 90352610
Neutrophil count increased 12.71 9.10 85 217611 19305 90391446
Infusion site scar 12.70 9.10 11 217685 595 90410156
Hypercalcaemia 12.70 9.10 132 217564 34108 90376643
Tachyarrhythmia 12.69 9.10 35 217661 5371 90405380
Aortic arteriosclerosis 12.68 9.10 44 217652 7640 90403111
Tricuspid valve incompetence 12.62 9.10 76 217620 16655 90394096
Full blood count abnormal 12.60 9.10 139 217557 36458 90374293
Glycosylated haemoglobin increased 12.58 9.10 72 217624 15490 90395261
Neuropathy peripheral 12.58 9.10 424 217272 136546 90274205
Neutropenic sepsis 12.56 9.10 15 217681 18115 90392636
Renal cell carcinoma stage IV 12.55 9.10 4 217692 23 90410728
Pyelonephritis 12.54 9.10 91 217605 21225 90389526
Mandibular mass 12.53 9.10 7 217689 184 90410567
Haemorrhagic cyst 12.53 9.10 8 217688 270 90410481
Posterior capsule opacification 12.33 9.10 7 217689 190 90410561
Coma 12.32 9.10 244 217452 72388 90338363
Frequent bowel movements 12.32 9.10 83 217613 56852 90353899
Rash pruritic 12.26 9.10 271 217425 81943 90328808
Early satiety 12.26 9.10 16 217680 1391 90409360
Cardiotoxicity 12.26 9.10 6 217690 11383 90399368
Diverticulum oesophageal 12.23 9.10 7 217689 193 90410558
Teeth brittle 12.18 9.10 11 217685 629 90410122
Skin necrosis 12.17 9.10 76 217620 16865 90393886
Dermatitis exfoliative 12.17 9.10 35 217661 5501 90405250
Patent ductus arteriosus 12.17 9.10 31 217665 4538 90406213
Defaecation disorder 12.14 9.10 13 217683 916 90409835
Bile duct stone 12.14 9.10 29 217667 4078 90406673
Renal lymphocele 12.13 9.10 5 217691 65 90410686
Ischaemic stroke 12.12 9.10 93 217603 22073 90388678
Poor personal hygiene 12.08 9.10 9 217687 392 90410359
Persistent depressive disorder 12.07 9.10 15 217681 1242 90409509
Mesenteric artery stenosis 12.06 9.10 5 217691 66 90410685
Coma acidotic 12.05 9.10 6 217690 124 90410627
Tri-iodothyronine free decreased 12.04 9.10 9 217687 394 90410357
Newborn persistent pulmonary hypertension 12.03 9.10 8 217688 290 90410461
Renal tubular atrophy 12.02 9.10 13 217683 927 90409824
Vagus nerve disorder 12.00 9.10 6 217690 125 90410626
Tongue pruritus 11.99 9.10 12 217684 781 90409970
Anal inflammation 11.94 9.10 9 217687 399 90410352
Type I hypersensitivity 11.91 9.10 29 217667 4126 90406625
Pulmonary artery stenosis 11.91 9.10 8 217688 295 90410456
Herpes simplex test positive 11.90 9.10 9 217687 401 90410350
Dyslipidaemia 11.89 9.10 52 217644 10055 90400696
Uveal melanoma 11.89 9.10 4 217692 28 90410723
Psychotic disorder 11.87 9.10 37 217659 31193 90379558
Escherichia infection 11.86 9.10 72 217624 15823 90394928
Spondylitis 11.80 9.10 10 217686 14168 90396583
Rash scarlatiniform 11.79 9.10 7 217689 207 90410544
Blood pressure diastolic abnormal 11.77 9.10 85 217611 19796 90390955
Cholangitis 11.75 9.10 41 217655 7141 90403610
Abortion induced 11.72 9.10 7 217689 11881 90398870
Oesophagitis ulcerative 11.70 9.10 12 217684 804 90409947
Potentiating drug interaction 11.69 9.10 35 217661 5627 90405124
Pneumonia aspiration 11.68 9.10 150 217546 40790 90369961
Paraesthesia 11.66 9.10 487 217209 249839 90160912
Portal vein dilatation 11.65 9.10 4 217692 30 90410721
Atrial fibrillation 11.61 9.10 411 217285 133200 90277551
Aplasia 11.60 9.10 28 217668 3963 90406788
Junctional ectopic tachycardia 11.59 9.10 7 217689 214 90410537
Cardiac failure acute 11.55 9.10 58 217638 11871 90398880
Hepatitis A antibody positive 11.55 9.10 5 217691 74 90410677
Mucosal pain 11.53 9.10 4 217692 31 90410720
Cardiothoracic ratio increased 11.53 9.10 4 217692 31 90410720
Blood pressure decreased 11.52 9.10 248 217448 74647 90336104
Neonatal respiratory failure 11.51 9.10 8 217688 312 90410439
Oral fungal infection 11.48 9.10 25 217671 3307 90407444
Injection site hypersensitivity 11.43 9.10 22 217674 2665 90408086
Diabetic ketosis 11.39 9.10 10 217686 551 90410200
Hypoparathyroidism 11.34 9.10 13 217683 988 90409763
Chronic kidney disease-mineral and bone disorder 11.31 9.10 6 217690 142 90410609
Sudden death 11.25 9.10 54 217642 10855 90399896
Urinary tract infection 11.23 9.10 866 216830 304766 90105985
Fungal infection 11.21 9.10 154 217542 42507 90368244
Joint noise 11.20 9.10 33 217663 5257 90405494
Oral pain 11.19 9.10 124 217572 32559 90378192
Hypertriglyceridaemia 11.19 9.10 43 217653 7846 90402905
Hot flush 11.18 9.10 203 217493 59285 90351466
Acute cutaneous lupus erythematosus 11.14 9.10 8 217688 329 90410422
Placental calcification 11.11 9.10 4 217692 35 90410716
Feeling jittery 11.07 9.10 69 217627 15302 90395449
Ileus paralytic 11.04 9.10 32 217664 5053 90405698
Small intestinal stenosis 11.03 9.10 11 217685 713 90410038
Lung opacity 11.01 9.10 36 217660 6066 90404685
Monoclonal gammopathy 11.01 9.10 12 217684 863 90409888
Neuroleptic malignant syndrome 10.99 9.10 12 217684 15084 90395667
Airway remodelling 10.98 9.10 5 217691 84 90410667
Iron deficiency 10.96 9.10 49 217647 9563 90401188
Toxic epidermal necrolysis 10.95 9.10 123 217573 32405 90378346
Calcium metabolism disorder 10.94 9.10 6 217690 152 90410599
Oesophagitis 10.94 9.10 75 217621 17174 90393577
Resting tremor 10.92 9.10 12 217684 871 90409880
Renal tubular necrosis 10.90 9.10 66 217630 14489 90396262
Hypophosphataemia 10.90 9.10 67 217629 14787 90395964
Platelet count decreased 10.86 9.10 417 217279 136552 90274199
Faeces discoloured 10.86 9.10 88 217608 21232 90389519
Lichen planus 10.85 9.10 22 217674 2769 90407982
Dysplasia 10.84 9.10 15 217681 1379 90409372
Gastric cancer 10.84 9.10 32 217664 5104 90405647
Respiratory distress 10.82 9.10 142 217554 38804 90371947
Cystic fibrosis 10.77 9.10 27 217669 3914 90406837
Immobilisation syndrome 10.76 9.10 9 217687 464 90410287
Hepatitis fulminant 10.75 9.10 27 217669 3918 90406833
Adverse reaction 10.74 9.10 36 217660 29676 90381075
Renal tuberculosis 10.73 9.10 4 217692 39 90410712
Peripheral nerve lesion 10.70 9.10 9 217687 468 90410283
Vitamin B1 deficiency 10.66 9.10 9 217687 470 90410281
Rash vesicular 10.66 9.10 17 217679 18180 90392571
Radial nerve palsy 10.66 9.10 10 217686 601 90410150
Vaginal discharge 10.65 9.10 19 217677 19445 90391306
Cardiac murmur functional 10.64 9.10 4 217692 40 90410711
Purpura senile 10.60 9.10 10 217686 605 90410146
Exposure to toxic agent 10.58 9.10 3 217693 7964 90402787
Respiratory paralysis 10.55 9.10 4 217692 41 90410710
Adrenocorticotropic hormone deficiency 10.49 9.10 11 217685 757 90409994
Encephalitis toxic 10.47 9.10 4 217692 42 90410709
Injection site haemorrhage 10.45 9.10 34 217662 28284 90382467
Demyelination 10.44 9.10 43 217653 8097 90402654
Idiopathic pulmonary fibrosis 10.44 9.10 16 217680 1614 90409137
Diverticulum 10.43 9.10 57 217639 12056 90398695
Anti-thyroid antibody positive 10.42 9.10 9 217687 485 90410266
Atypical fracture 10.40 9.10 12 217684 919 90409832
Rash morbilliform 10.38 9.10 27 217669 4002 90406749
Sputum abnormal 10.38 9.10 11 217685 766 90409985
Asthenia 10.36 9.10 1448 216248 532303 89878448
Pulmonary oedema 10.35 9.10 208 217488 61872 90348879
Renal hypertension 10.34 9.10 6 217690 170 90410581
Subdural haematoma 10.34 9.10 72 217624 16573 90394178
Facial asymmetry 10.30 9.10 12 217684 928 90409823
CSF protein increased 10.27 9.10 11 217685 775 90409976
Haematotoxicity 10.24 9.10 9 217687 12526 90398225
Iron binding capacity total increased 10.23 9.10 5 217691 99 90410652
Hypercapnic coma 10.23 9.10 7 217689 266 90410485
Pre-eclampsia 10.21 9.10 7 217689 11041 90399710
Vitamin B12 decreased 10.19 9.10 32 217664 5278 90405473
Aeromonas infection 10.18 9.10 6 217690 175 90410576
Radiculopathy 10.18 9.10 18 217678 18487 90392264
Colitis ulcerative 10.18 9.10 94 217602 60172 90350579
Thrombocytopenic purpura 10.18 9.10 17 217679 1844 90408907
Sprue-like enteropathy 10.17 9.10 12 217684 941 90409810
Eye injury 10.16 9.10 7 217689 11013 90399738
Body height decreased 10.13 9.10 56 217640 11893 90398858
Hepatic enzyme decreased 10.12 9.10 12 217684 946 90409805
Hypoplastic anaemia 10.11 9.10 3 217693 13 90410738
Urine potassium decreased 10.11 9.10 3 217693 13 90410738
Concussion 10.10 9.10 53 217643 11038 90399713
Blood glucose increased 10.10 9.10 300 217396 94946 90315805
Injection site pain 10.09 9.10 329 217367 173370 90237381
Osteoporosis 10.07 9.10 167 217529 96364 90314387
Cerebral haemorrhage 10.06 9.10 127 217569 34395 90376356
Hemianopia 10.05 9.10 18 217678 2064 90408687
Ovarian cystectomy 10.03 9.10 6 217690 180 90410571
Small intestine ulcer 10.02 9.10 8 217688 386 90410365
Distal intestinal obstruction syndrome 9.98 9.10 9 217687 514 90410237
Foramen magnum stenosis 9.94 9.10 6 217690 183 90410568
Oesophageal motility disorder 9.93 9.10 10 217686 656 90410095
Feeling abnormal 9.89 9.10 494 217202 166741 90244010
Cardiac arrest 9.85 9.10 185 217511 104750 90306001
Gastrointestinal ischaemia 9.83 9.10 6 217690 187 90410564
Vulval disorder 9.77 9.10 14 217682 1330 90409421
Ischaemic nephropathy 9.76 9.10 3 217693 15 90410736
Urticaria papular 9.76 9.10 5 217691 110 90410641
Prothrombin time ratio decreased 9.75 9.10 12 217684 983 90409768
Wrong patient received product 9.69 9.10 24 217672 3453 90407298
Anaemia folate deficiency 9.65 9.10 9 217687 537 90410214
Urinary tract stoma complication 9.64 9.10 4 217692 53 90410698
Parosmia 9.59 9.10 38 217658 7031 90403720
Haemorrhagic disorder 9.59 9.10 12 217684 1000 90409751
Chronic gastritis 9.57 9.10 25 217671 3716 90407035
Post procedural haematoma 9.55 9.10 14 217682 1358 90409393
Diverticulum intestinal haemorrhagic 9.52 9.10 16 217680 1745 90409006
Electrocardiogram repolarisation abnormality 9.52 9.10 14 217682 1362 90409389
Blood creatine phosphokinase decreased 9.49 9.10 10 217686 692 90410059
Haemorrhoids 9.46 9.10 102 217594 26600 90384151
Epilepsy congenital 9.45 9.10 3 217693 17 90410734
Gastrointestinal tract mucosal discolouration 9.45 9.10 3 217693 17 90410734
Transplant rejection 9.45 9.10 10 217686 12748 90398003
Hypoparathyroidism secondary 9.44 9.10 4 217692 56 90410695
Crystalluria 9.42 9.10 9 217687 553 90410198
Gastrointestinal tract mucosal pigmentation 9.41 9.10 10 217686 699 90410052
Cold type haemolytic anaemia 9.39 9.10 7 217689 305 90410446
Ejection fraction decreased 9.36 9.10 32 217664 26221 90384530
Blood uric acid increased 9.34 9.10 40 217656 7664 90403087
Fluid retention 9.32 9.10 152 217544 87939 90322812
Immune-mediated myositis 9.31 9.10 19 217677 2402 90408349
Cystocele repair 9.31 9.10 3 217693 18 90410733
Hepatic cirrhosis 9.30 9.10 102 217594 63151 90347600
Prinzmetal angina 9.29 9.10 12 217684 1033 90409718
Appetite disorder 9.27 9.10 45 217651 9088 90401663
Body temperature increased 9.27 9.10 66 217630 44644 90366107
Thrombosis 9.25 9.10 236 217460 73015 90337736
Multiple sclerosis 9.25 9.10 105 217591 27735 90383016
Splenic haemorrhage 9.21 9.10 6 217690 210 90410541
Chemotherapeutic drug level increased 9.21 9.10 6 217690 210 90410541
Renal infarct 9.17 9.10 15 217681 1600 90409151
Lower gastrointestinal haemorrhage 9.16 9.10 44 217652 8848 90401903
Hyporesponsive to stimuli 9.15 9.10 15 217681 1602 90409149
Kidney fibrosis 9.15 9.10 18 217678 2216 90408535
Pulmonary embolism 9.15 9.10 393 217303 130427 90280324
Throat clearing 9.12 9.10 25 217671 3822 90406929
Leukocyturia 9.12 9.10 15 217681 1607 90409144
Paraesthesia oral 9.12 9.10 42 217654 31617 90379134
Troponin T increased 9.11 9.10 15 217681 1608 90409143
Subacute hepatic failure 9.11 9.10 5 217691 127 90410624

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Chronic kidney disease 555.53 10.08 690 124765 46551 42449329
Acute kidney injury 235.97 10.08 1866 123589 365471 42130409
Hypomagnesaemia 218.67 10.08 339 125116 28149 42467731
Death 198.01 10.08 718 124737 470467 42025413
Interstitial lung disease 189.22 10.08 584 124871 77878 42418002
Drug ineffective 184.58 10.08 1096 124359 629101 41866779
Toxicity to various agents 183.11 10.08 244 125211 228892 42266988
Hepatocellular injury 145.60 10.08 255 125200 23423 42472457
Drug abuse 145.57 10.08 63 125392 104708 42391172
Nightmare 144.35 10.08 262 125193 24750 42471130
Hypocalcaemia 143.33 10.08 291 125164 29882 42465998
Renal injury 138.82 10.08 176 125279 12104 42483776
Tubulointerstitial nephritis 133.26 10.08 290 125165 31258 42464622
End stage renal disease 131.20 10.08 200 125255 16358 42479522
Cholestasis 125.19 10.08 290 125165 32589 42463291
Cardiospasm 122.47 10.08 74 125381 1833 42494047
Completed suicide 114.71 10.08 71 125384 96394 42399486
Palmoplantar keratoderma 111.12 10.08 74 125381 2180 42493700
Tinnitus 108.81 10.08 254 125201 28684 42467196
Tension headache 100.21 10.08 82 125373 3332 42492548
Pruritus genital 98.34 10.08 73 125382 2566 42493314
Toxic skin eruption 96.53 10.08 157 125298 13573 42482307
Eosinophilia 91.76 10.08 258 125197 32641 42463239
Sleep terror 89.52 10.08 72 125383 2854 42493026
Migraine 87.93 10.08 216 125239 25198 42470682
Immunisation 86.47 10.08 51 125404 1207 42494673
Atrial tachycardia 82.74 10.08 80 125375 4060 42491820
Occult blood 81.26 10.08 45 125410 941 42494939
Carotid artery occlusion 80.00 10.08 79 125376 4115 42491765
Hypergastrinaemia 77.38 10.08 28 125427 198 42495682
Nephrogenic anaemia 73.58 10.08 61 125394 2525 42493355
Agranulocytosis 72.00 10.08 226 125229 30386 42465494
Facial pain 71.70 10.08 75 125380 4185 42491695
Pericarditis 71.51 10.08 136 125319 13308 42482572
Hypokalaemia 70.12 10.08 405 125050 71316 42424564
Hepatojugular reflux 70.08 10.08 36 125419 643 42495237
Anosmia 69.59 10.08 81 125374 5095 42490785
Electrocardiogram Q wave abnormal 66.01 10.08 32 125423 502 42495378
Palpitations 61.33 10.08 304 125151 50493 42445387
Drug reaction with eosinophilia and systemic symptoms 60.51 10.08 265 125190 41810 42454070
Burns second degree 59.04 10.08 81 125374 6015 42489865
Physical deconditioning 58.78 10.08 52 125403 2353 42493527
Catarrh 58.68 10.08 80 125375 5906 42489974
Systemic lupus erythematosus 58.06 10.08 101 125354 9223 42486657
Systolic dysfunction 57.69 10.08 57 125398 2971 42492909
Drug ineffective for unapproved indication 57.65 10.08 32 125423 46131 42449749
Off label use 56.85 10.08 1439 124016 636896 41858984
Treatment failure 55.94 10.08 61 125394 62563 42433317
Neuropsychiatric lupus 55.37 10.08 17 125438 66 42495814
Renal failure 54.15 10.08 654 124801 143072 42352808
Inappropriate antidiuretic hormone secretion 53.45 10.08 137 125318 16404 42479476
Rhinitis 52.74 10.08 112 125343 11865 42484015
Eczema 51.56 10.08 218 125237 33868 42462012
Hypopnoea 51.21 10.08 87 125368 7795 42488085
Nephrolithiasis 50.72 10.08 229 125226 36601 42459279
Hyperhidrosis 49.83 10.08 445 125010 90067 42405813
Hyperkalaemia 49.25 10.08 405 125050 80053 42415827
Steroid dependence 48.80 10.08 78 125377 6644 42489236
Sedation 48.52 10.08 198 125257 30277 42465603
Gingival pain 47.76 10.08 88 125367 8406 42487474
Disease progression 47.62 10.08 239 125216 143417 42352463
Pancreatitis acute 47.20 10.08 210 125245 33354 42462526
Degenerative mitral valve disease 46.91 10.08 21 125434 272 42495608
Therapy non-responder 46.53 10.08 53 125402 53306 42442574
Parosmia 46.19 10.08 82 125373 7609 42488271
Product dose omission issue 46.09 10.08 266 125189 154099 42341781
Hypertensive nephropathy 44.52 10.08 24 125431 475 42495405
Drug resistance 42.39 10.08 24 125431 34224 42461656
Pain of skin 42.06 10.08 81 125374 7999 42487881
Gastric polyps 41.75 10.08 37 125418 1678 42494202
Gamma-glutamyltransferase increased 41.75 10.08 198 125257 32299 42463581
Helicobacter gastritis 40.68 10.08 33 125422 1324 42494556
Acquired haemophilia 40.51 10.08 36 125419 1639 42494241
Subarachnoid haemorrhage 39.86 10.08 113 125342 14359 42481521
Brain scan abnormal 38.99 10.08 31 125424 1208 42494672
Colitis microscopic 38.77 10.08 47 125408 3086 42492794
Ventricular hypokinesia 38.30 10.08 71 125384 6813 42489067
Hemiplegia 37.41 10.08 76 125379 7803 42488077
Hyponatraemia 36.16 10.08 457 124998 101005 42394875
Rash maculo-papular 35.48 10.08 210 125245 37293 42458587
Cardiac failure 35.03 10.08 474 124981 106382 42389498
Pulmonary vascular disorder 34.91 10.08 23 125432 665 42495215
Cholangitis 34.82 10.08 89 125366 10638 42485242
Cerebral artery thrombosis 34.57 10.08 29 125426 1220 42494660
Cardiac murmur 34.45 10.08 99 125356 12676 42483204
Idiopathic pulmonary fibrosis 34.21 10.08 54 125401 4550 42491330
Acute generalised exanthematous pustulosis 34.01 10.08 77 125378 8518 42487362
Drug intolerance 33.91 10.08 122 125333 80302 42415578
Vertigo 33.57 10.08 194 125261 34153 42461727
Jaundice 33.57 10.08 195 125260 34394 42461486
Inferior vena cava dilatation 33.54 10.08 24 125431 796 42495084
Ischaemic stroke 33.47 10.08 142 125313 22091 42473789
Cardiac failure congestive 33.41 10.08 134 125321 85468 42410412
Myelosuppression 33.35 10.08 42 125413 40419 42455461
Rash papular 33.29 10.08 93 125362 11718 42484162
Eye injury 33.27 10.08 26 125429 988 42494892
Physical examination abnormal 32.50 10.08 19 125436 442 42495438
Chronic kidney disease-mineral and bone disorder 32.35 10.08 19 125436 446 42495434
Nephropathy 32.03 10.08 66 125389 6845 42489035
Radiation pneumonitis 31.51 10.08 41 125414 2892 42492988
Pulmonary valve disease 31.41 10.08 18 125437 403 42495477
Ventricular tachycardia 31.23 10.08 173 125282 29987 42465893
Carotid arteriosclerosis 30.53 10.08 36 125419 2296 42493584
Tumour fistulisation 30.37 10.08 12 125443 111 42495769
Pericardial disease 30.32 10.08 19 125436 503 42495377
Administration site inflammation 30.22 10.08 10 125445 52 42495828
Thrombosis 30.18 10.08 102 125353 68409 42427471
Nicotine dependence 30.01 10.08 21 125434 672 42495208
Cardiac arrest 29.68 10.08 194 125261 109126 42386754
Anaemia macrocytic 29.66 10.08 44 125411 3511 42492369
Mixed liver injury 28.56 10.08 49 125406 4425 42491455
Occupational dermatitis 28.50 10.08 11 125444 95 42495785
No adverse event 27.71 10.08 45 125410 38976 42456904
Accidental overdose 27.68 10.08 160 125295 28170 42467710
Eosinophilic colitis 27.64 10.08 15 125440 301 42495579
Febrile bone marrow aplasia 27.55 10.08 79 125376 10102 42485778
Product used for unknown indication 27.44 10.08 25 125430 1176 42494704
Cardiac aneurysm 27.26 10.08 24 125431 1079 42494801
Tubulointerstitial nephritis and uveitis syndrome 27.09 10.08 11 125444 110 42495770
Nipple swelling 27.04 10.08 16 125439 381 42495499
Granulomatous rosacea 26.97 10.08 12 125443 153 42495727
Aggression 26.86 10.08 56 125399 44107 42451773
Swelling 26.79 10.08 78 125377 54807 42441073
Dyspnoea at rest 26.42 10.08 46 125409 4203 42491677
Therapy partial responder 26.29 10.08 13 125442 20008 42475872
Ventricular fibrillation 26.17 10.08 30 125425 30093 42465787
Therapeutic product effect incomplete 25.85 10.08 114 125341 70825 42425055
Alcohol poisoning 25.79 10.08 64 125391 7510 42488370
Gastroenteritis eosinophilic 25.78 10.08 13 125442 223 42495657
Ventricular arrhythmia 25.68 10.08 57 125398 6222 42489658
Colitis ulcerative 25.68 10.08 148 125307 26027 42469853
Drug hypersensitivity 25.67 10.08 179 125276 99210 42396670
Major depression 25.55 10.08 52 125403 5346 42490534
Chronic obstructive pulmonary disease 25.13 10.08 98 125357 63016 42432864
Sleep disorder due to a general medical condition 25.01 10.08 10 125445 17443 42478437
Muscle twitching 25.01 10.08 84 125371 11696 42484184
Foetal exposure during pregnancy 24.75 10.08 65 125390 47246 42448634
Rhabdomyolysis 24.71 10.08 344 125111 77675 42418205
Helicobacter test positive 24.62 10.08 20 125435 804 42495076
Wheezing 24.51 10.08 81 125374 54700 42441180
Abdominal pain upper 24.47 10.08 360 125095 82249 42413631
Cardiac discomfort 24.40 10.08 19 125436 718 42495162
Vascular purpura 24.18 10.08 31 125424 2155 42493725
Bacterial infection 23.97 10.08 28 125427 27851 42468029
Cross sensitivity reaction 23.84 10.08 27 125428 1648 42494232
Immune-mediated hepatic disorder 23.74 10.08 33 125422 2481 42493399
Mental status changes 23.48 10.08 56 125399 42059 42453821
Hypophosphataemic osteomalacia 23.43 10.08 11 125444 160 42495720
Diplopia 23.39 10.08 120 125335 20196 42475684
Occupational exposure to air contaminants 23.37 10.08 11 125444 161 42495719
Sudden death 23.34 10.08 104 125351 16525 42479355
Device dependence 23.22 10.08 8 125447 48 42495832
Drug dependence 23.15 10.08 31 125424 29063 42466817
Drug interaction 23.03 10.08 983 124472 266016 42229864
Eye pruritus 23.02 10.08 80 125375 11332 42484548
Injection site pain 22.85 10.08 90 125365 57708 42438172
Hepatic cytolysis 22.67 10.08 146 125309 26698 42469182
Echocardiogram abnormal 22.53 10.08 23 125432 1247 42494633
Diabetic nephropathy 22.51 10.08 31 125424 2310 42493570
Ureteric compression 22.41 10.08 13 125442 298 42495582
Cell death 22.39 10.08 35 125420 2924 42492956
Dermatitis bullous 22.29 10.08 65 125390 8391 42487489
Blindness 21.98 10.08 108 125347 17870 42478010
Respiratory arrest 21.90 10.08 31 125424 28393 42467487
Hyperkaliuria 21.74 10.08 9 125446 95 42495785
Full blood count abnormal 21.64 10.08 34 125421 29842 42466038
Hepatocellular carcinoma 21.61 10.08 63 125392 8131 42487749
Nerve degeneration 21.54 10.08 11 125444 194 42495686
Allergic keratitis 21.51 10.08 6 125449 15 42495865
Photosensitivity reaction 20.59 10.08 83 125372 12619 42483261
Drug-induced liver injury 20.44 10.08 187 125268 38086 42457794
Pharyngeal necrosis 20.34 10.08 8 125447 73 42495807
Respiratory symptom 20.29 10.08 4 125451 11102 42484778
Neurotoxicity 20.07 10.08 24 125431 23627 42472253
Akinesia 19.78 10.08 30 125425 2442 42493438
Respiratory depression 19.63 10.08 16 125439 18852 42477028
Sleep disorder 19.58 10.08 74 125381 48021 42447859
Preterm premature rupture of membranes 19.53 10.08 8 125447 82 42495798
Therapy interrupted 19.50 10.08 22 125433 22228 42473652
Lactic acidosis 19.27 10.08 211 125244 45050 42450830
Capillary permeability increased 19.21 10.08 6 125449 25 42495855
Cerebellar syndrome 19.19 10.08 32 125423 2823 42493057
Polyp 19.00 10.08 42 125413 4572 42491308
Anticoagulation drug level increased 18.81 10.08 15 125440 587 42495293
Impaired work ability 18.80 10.08 78 125377 12013 42483867
Pancreatic steatosis 18.68 10.08 10 125445 195 42495685
Overlap syndrome 18.65 10.08 12 125443 333 42495547
Lethargy 18.54 10.08 73 125382 46817 42449063
Spinal osteoarthritis 18.49 10.08 62 125393 8624 42487256
Appendicitis 18.49 10.08 20 125435 20593 42475287
Weight increased 18.45 10.08 216 125239 107767 42388113
Lung disorder 18.42 10.08 219 125236 47704 42448176
Hypoparathyroidism 18.37 10.08 16 125439 709 42495171
Gastric cancer 18.14 10.08 53 125402 6850 42489030
Transient ischaemic attack 18.10 10.08 165 125290 33574 42462306
Haematotoxicity 18.00 10.08 5 125450 10980 42484900
Urticaria papular 17.98 10.08 8 125447 102 42495778
Febrile neutropenia 17.92 10.08 413 125042 185290 42310590
Craniotabes 17.79 10.08 5 125450 13 42495867
Hypotension 17.68 10.08 601 124854 257030 42238850
Hyperchlorhydria 17.64 10.08 15 125440 643 42495237
Cataract 17.62 10.08 152 125303 30452 42465428
Muscle haemorrhage 17.50 10.08 38 125417 4087 42491793
Phaeochromocytoma malignant 17.42 10.08 7 125448 68 42495812
Malaise 17.37 10.08 777 124678 211379 42284501
Treatment noncompliance 17.34 10.08 55 125400 37617 42458263
Hiatus hernia 17.26 10.08 60 125395 8500 42487380
Hypovitaminosis 17.26 10.08 16 125439 770 42495110
Duodenal polyp 17.17 10.08 11 125444 303 42495577
Troponin T increased 17.16 10.08 30 125425 2750 42493130
Ventricular enlargement 17.16 10.08 15 125440 668 42495212
Haematoma muscle 17.07 10.08 26 125429 2124 42493756
Blindness cortical 16.93 10.08 13 125442 481 42495399
Hyperkinetic heart syndrome 16.82 10.08 8 125447 120 42495760
High frequency ablation 16.75 10.08 9 125446 177 42495703
Dysgeusia 16.74 10.08 164 125291 34025 42461855
Substance abuse 16.71 10.08 3 125452 8902 42486978
Thrombocytopenia 16.71 10.08 702 124753 189577 42306303
Mitral valve incompetence 16.68 10.08 94 125361 16395 42479485
Face oedema 16.63 10.08 82 125373 13584 42482296
Rectal haemorrhage 16.63 10.08 221 125234 49385 42446495
Respiratory distress 16.47 10.08 192 125263 41628 42454252
Gastric adenoma 16.37 10.08 5 125450 19 42495861
Sepsis 16.37 10.08 454 125001 198880 42297000
Therapeutic response decreased 16.36 10.08 55 125400 36957 42458923
Nipple pain 16.29 10.08 18 125437 1069 42494811
Multiple sclerosis relapse 16.26 10.08 11 125444 14253 42481627
Renal haemangioma 16.17 10.08 5 125450 20 42495860
Psychotic disorder 16.15 10.08 39 125416 29169 42466711
Insulin autoimmune syndrome 16.06 10.08 13 125442 520 42495360
Shock haemorrhagic 16.04 10.08 92 125363 16150 42479730
Hypoparathyroidism secondary 15.97 10.08 9 125446 195 42495685
Hepatic haematoma 15.96 10.08 12 125443 430 42495450
Fixed eruption 15.83 10.08 27 125428 2427 42493453
Spontaneous haematoma 15.82 10.08 15 125440 743 42495137
Myoglobinaemia 15.80 10.08 9 125446 199 42495681
Benign abdominal neoplasm 15.75 10.08 7 125448 89 42495791
Abdominal discomfort 15.73 10.08 310 125145 74945 42420935
Iron deficiency anaemia 15.70 10.08 78 125377 12961 42482919
Abnormal behaviour 15.70 10.08 34 125421 26417 42469463
Dermatophytosis of nail 15.68 10.08 7 125448 90 42495790
Dizziness 15.61 10.08 588 124867 248666 42247214
Fluid imbalance 15.61 10.08 11 125444 356 42495524
Sensitisation 15.59 10.08 10 125445 276 42495604
Polymyalgia rheumatica 15.57 10.08 26 125429 2297 42493583
Chest expansion decreased 15.47 10.08 8 125447 145 42495735
Food interaction 15.45 10.08 17 125438 1005 42494875
Hospitalisation 15.43 10.08 142 125313 74188 42421692
Large intestine polyp 15.38 10.08 61 125394 9204 42486676
Essential tremor 15.38 10.08 16 125439 887 42494993
Infective exacerbation of chronic obstructive airways disease 15.32 10.08 24 125431 2009 42493871
Swollen tongue 15.27 10.08 111 125344 21120 42474760
Inflammatory pain 15.20 10.08 13 125442 562 42495318
Ocular myasthenia 15.16 10.08 13 125442 564 42495316
Hypoalbuminaemia 15.14 10.08 88 125367 15522 42480358
Fracture delayed union 15.05 10.08 6 125449 57 42495823
Septic shock 14.83 10.08 364 125091 91308 42404572
Rebound acid hypersecretion 14.78 10.08 7 125448 104 42495776
Arteriosclerosis coronary artery 14.76 10.08 20 125435 18657 42477223
Obesity 14.73 10.08 16 125439 16443 42479437
Amnesia 14.71 10.08 138 125317 28299 42467581
Injury 14.69 10.08 27 125428 22289 42473591
Dermatomyositis 14.67 10.08 21 125434 1622 42494258
Cerebral haematoma 14.67 10.08 43 125412 5567 42490313
Antiphospholipid antibodies positive 14.66 10.08 11 125444 393 42495487
Venoocclusive liver disease 14.61 10.08 6 125449 10296 42485584
Carotid artery stenosis 14.54 10.08 42 125413 5394 42490486
Acquired cystic kidney disease 14.49 10.08 3 125452 0 42495880
Oral pustule 14.47 10.08 9 125446 235 42495645
Jaundice cholestatic 14.45 10.08 41 125414 5212 42490668
Hyperparathyroidism secondary 14.24 10.08 22 125433 1820 42494060
Oesophageal adenocarcinoma 14.16 10.08 16 125439 974 42494906
Neuroleptic malignant syndrome 14.11 10.08 26 125429 21446 42474434
Vitamin B12 deficiency 14.11 10.08 39 125416 4883 42490997
Cholesteatoma 14.04 10.08 6 125449 69 42495811
Disturbance in attention 14.01 10.08 142 125313 29724 42466156
Excessive cerumen production 13.91 10.08 10 125445 334 42495546
Acute coronary syndrome 13.90 10.08 83 125372 14782 42481098
Syringe issue 13.83 10.08 4 125451 8552 42487328
Radiation necrosis 13.76 10.08 9 125446 257 42495623
Seizure 13.72 10.08 261 125194 120300 42375580
Joint swelling 13.67 10.08 131 125324 67891 42427989
Hepatic encephalopathy 13.62 10.08 89 125366 16353 42479527
Papillary renal cell carcinoma 13.61 10.08 10 125445 346 42495534
Exercise tolerance decreased 13.54 10.08 44 125411 6022 42489858
Pulseless electrical activity 13.53 10.08 4 125451 8433 42487447
Xerosis 13.44 10.08 15 125440 901 42494979
Asthma 13.39 10.08 118 125337 62196 42433684
Cholestatic liver injury 13.33 10.08 32 125423 3677 42492203
Coronary artery stenosis 13.15 10.08 63 125392 10316 42485564
Areflexia 13.14 10.08 32 125423 3711 42492169
Type III immune complex mediated reaction 13.07 10.08 12 125443 570 42495310
Arthropathy 13.07 10.08 44 125411 29553 42466327
Mitral valve disease 13.05 10.08 19 125436 1491 42494389
Chillblains 12.97 10.08 5 125450 43 42495837
Blood uric acid increased 12.95 10.08 16 125439 15531 42480349
Hypoxia 12.94 10.08 137 125318 69649 42426231
Oesophagitis ulcerative 12.93 10.08 15 125440 940 42494940
Hyperthermia 12.93 10.08 72 125383 12502 42483378
Breath sounds abnormal 12.90 10.08 10 125445 12083 42483797
Renal mass 12.88 10.08 22 125433 1980 42493900
Bronchiectasis 12.84 10.08 94 125361 17925 42477955
Eosinophilic oesophagitis 12.82 10.08 13 125442 699 42495181
Pathogen resistance 12.82 10.08 9 125446 11441 42484439
Intestinal haematoma 12.79 10.08 8 125447 211 42495669
Anastomotic ulcer 12.77 10.08 11 125444 480 42495400
Bladder cancer 12.73 10.08 19 125436 17028 42478852
Hepatitis cholestatic 12.72 10.08 60 125395 9764 42486116
Metabolic acidosis 12.71 10.08 219 125236 51639 42444241
Immune reconstitution inflammatory syndrome 12.71 10.08 7 125448 10136 42485744
Palmoplantar pustulosis 12.69 10.08 11 125444 484 42495396
Multiple-drug resistance 12.64 10.08 3 125452 7319 42488561
Aortic valve incompetence 12.43 10.08 45 125410 6503 42489377
Hyperchloruria 12.42 10.08 3 125452 3 42495877
Hypermagnesuria 12.42 10.08 3 125452 3 42495877
Device colour issue 12.38 10.08 4 125451 19 42495861
Melaena 12.32 10.08 171 125284 38575 42457305
Dermatitis atopic 12.32 10.08 11 125444 12393 42483487
Nasal crusting 12.30 10.08 11 125444 505 42495375
Pulmonary oedema 12.29 10.08 99 125356 53173 42442707
Accidental exposure to product 12.28 10.08 26 125429 20367 42475513
Haematocrit decreased 12.17 10.08 57 125398 34851 42461029
Blood test abnormal 12.16 10.08 12 125443 12894 42482986
Angioedema 12.14 10.08 184 125271 42293 42453587
Malignant neoplasm of unknown primary site 12.10 10.08 10 125445 412 42495468
Exposure during pregnancy 12.08 10.08 5 125450 8543 42487337
Septic arthritis staphylococcal 12.06 10.08 11 125444 518 42495362
Enterochromaffin cell hyperplasia 12.06 10.08 4 125451 21 42495859
Cardiorenal syndrome 12.05 10.08 14 125441 879 42495001
Circumoral oedema 12.00 10.08 6 125449 101 42495779
Cancer pain 12.00 10.08 30 125425 3537 42492343
Drug eruption 11.95 10.08 112 125343 22963 42472917
Antibody test abnormal 11.82 10.08 9 125446 329 42495551
Peripheral venous disease 11.79 10.08 27 125428 3009 42492871
Neuropathy peripheral 11.74 10.08 220 125235 101633 42394247
Prostate cancer 11.72 10.08 80 125375 44563 42451317
Embedded device 11.70 10.08 10 125445 432 42495448
Hypovolaemia 11.63 10.08 10 125445 11475 42484405
Prurigo 11.55 10.08 12 125443 664 42495216
Contraindicated product administered 11.55 10.08 37 125418 25235 42470645
Blood glucose decreased 11.46 10.08 15 125440 14204 42481676
Conjunctival ulcer 11.43 10.08 5 125450 61 42495819
Localised infection 11.43 10.08 27 125428 20346 42475534
Nodule 11.42 10.08 12 125443 12522 42483358
Gastrointestinal submucosal tumour 11.40 10.08 6 125449 113 42495767
Renal cyst 11.35 10.08 59 125396 9980 42485900
Cerebral infarction 11.35 10.08 141 125314 31028 42464852
Haemobilia 11.33 10.08 10 125445 451 42495429
Joint injury 11.31 10.08 16 125439 14660 42481220
Haemoglobin decreased 11.31 10.08 300 125155 132171 42363709
Adverse event 11.24 10.08 34 125421 23606 42472274
Bullous impetigo 11.22 10.08 3 125452 6 42495874
Cholecystitis 11.19 10.08 71 125384 12917 42482963
Brief psychotic disorder with marked stressors 11.16 10.08 8 125447 266 42495614
Blood urea decreased 11.16 10.08 17 125438 1389 42494491
Postrenal failure 11.15 10.08 11 125444 572 42495308
Heat stroke 11.15 10.08 15 125440 1093 42494787
Pyelocaliectasis 11.13 10.08 17 125438 1392 42494488
BK virus infection 11.09 10.08 6 125449 8778 42487102
CSF volume increased 11.09 10.08 4 125451 28 42495852
Benign soft tissue neoplasm 11.07 10.08 6 125449 120 42495760
Synovitis 11.01 10.08 18 125437 15549 42480331
Enterocolitis 10.98 10.08 58 125397 9871 42486009
Hypercalciuria 10.97 10.08 9 125446 367 42495513
Osteopenia 10.96 10.08 42 125413 6236 42489644
False negative investigation result 10.91 10.08 8 125447 276 42495604
Metabolic alkalosis 10.86 10.08 21 125434 2080 42493800
Oesophageal ulcer haemorrhage 10.82 10.08 9 125446 374 42495506
Thrombocytopenic purpura 10.82 10.08 16 125439 1273 42494607
Cardiac pacemaker evaluation 10.81 10.08 6 125449 126 42495754
Pemphigoid 10.71 10.08 64 125391 11403 42484477
Eructation 10.67 10.08 38 125417 5448 42490432
Renal atrophy 10.65 10.08 16 125439 1291 42494589
Sinobronchitis 10.62 10.08 3 125452 8 42495872
Accident 10.58 10.08 3 125452 6500 42489380
Bursa removal 10.56 10.08 6 125449 132 42495748
Renal neoplasm 10.55 10.08 17 125438 1458 42494422
Stoma site discharge 10.54 10.08 17 125438 1459 42494421
Hyperphosphatasaemia 10.51 10.08 5 125450 75 42495805
On and off phenomenon 10.47 10.08 28 125427 3439 42492441
Renal impairment 10.43 10.08 410 125045 109818 42386062
Vasculitis 10.40 10.08 91 125364 18303 42477577
Duodenitis 10.39 10.08 38 125417 5518 42490362
Subdural haematoma 10.37 10.08 109 125346 23029 42472851
Arteriovenous fistula site haematoma 10.32 10.08 4 125451 35 42495845
Tumour perforation 10.32 10.08 10 125445 509 42495371
Pulmonary arterial hypertension 10.25 10.08 58 125397 10129 42485751
Complex regional pain syndrome 10.22 10.08 11 125444 634 42495246
Sinoatrial block 10.22 10.08 10 125445 515 42495365
Dehiscence 10.21 10.08 11 125444 635 42495245
Prinzmetal angina 10.20 10.08 16 125439 1341 42494539
Pneumobilia 10.17 10.08 6 125449 142 42495738
Hypocalciuria 10.12 10.08 3 125452 10 42495870
Alpha-1 anti-trypsin decreased 10.12 10.08 3 125452 10 42495870
Immune-mediated arthritis 10.12 10.08 8 125447 309 42495571

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Chronic kidney disease 666.91 9.27 932 303831 75359 110209177
Acute kidney injury 532.84 9.27 3279 301484 632151 109652385
Pemphigus 475.40 9.27 29 304734 214541 110069995
Interstitial lung disease 439.39 9.27 1097 303666 138237 110146299
Anti-cyclic citrullinated peptide antibody positive 427.36 9.27 17 304746 181967 110102569
Hypomagnesaemia 420.42 9.27 663 304100 59707 110224829
Glossodynia 412.98 9.27 60 304703 221944 110062592
Hand deformity 411.27 9.27 57 304706 218449 110066087
Duodenal ulcer perforation 406.11 9.27 20 304743 177680 110106856
Hepatocellular injury 384.68 9.27 579 304184 50063 110234473
Synovitis 373.30 9.27 144 304619 273948 110010588
Cholestasis 357.87 9.27 640 304123 63878 110220658
Wound 354.42 9.27 103 304660 234334 110050202
Helicobacter infection 352.96 9.27 43 304720 181834 110102702
Folliculitis 339.61 9.27 34 304729 167619 110116917
Rheumatic fever 320.82 9.27 3 304760 122576 110161960
Muscle injury 318.09 9.27 17 304746 140790 110143746
Carotid artery thrombosis 314.93 9.27 240 304523 9398 110275138
Drug ineffective 310.86 9.27 2692 302071 1517848 108766688
Neurologic neglect syndrome 304.84 9.27 232 304531 9066 110275470
Hemiplegia 302.34 9.27 343 304420 22439 110262097
Hypocalcaemia 295.16 9.27 594 304169 64772 110219764
Irritable bowel syndrome 281.89 9.27 55 304708 164160 110120376
Maternal exposure during pregnancy 280.52 9.27 178 304585 254705 110029831
Adjustment disorder 274.33 9.27 232 304531 10563 110273973
Personality disorder 272.35 9.27 249 304514 12588 110271948
Injury 269.53 9.27 77 304686 177188 110107348
Tubulointerstitial nephritis 257.98 9.27 504 304259 53780 110230756
Arthropathy 245.34 9.27 258 304505 287264 109997272
Cardiospasm 244.65 9.27 159 304604 4808 110279728
Psoriatic arthropathy 238.54 9.27 122 304641 196639 110087897
Completed suicide 238.21 9.27 191 304572 242190 110042346
Hyponatraemia 236.75 9.27 1206 303557 216447 110068089
Systemic lupus erythematosus 235.79 9.27 212 304551 254126 110030410
Palmoplantar keratoderma 232.90 9.27 159 304604 5228 110279308
C-reactive protein abnormal 229.98 9.27 40 304723 129655 110154881
Swelling 222.74 9.27 391 304372 350650 109933886
Pruritus genital 216.61 9.27 164 304599 6358 110278178
Lip dry 214.37 9.27 16 304747 100067 110184469
Affect lability 209.87 9.27 258 304505 18379 110266157
Breast cancer stage III 198.11 9.27 4 304759 79113 110205423
Discomfort 196.58 9.27 181 304582 214526 110070010
Exposure during pregnancy 195.32 9.27 109 304654 167315 110117221
Facet joint syndrome 195.12 9.27 20 304743 96808 110187728
Blister 195.10 9.27 203 304560 227173 110057363
Death 195.01 9.27 1129 303634 697740 109586796
Obesity 194.45 9.27 38 304725 113313 110171223
Toxicity to various agents 193.75 9.27 677 304086 479878 109804658
Sleep terror 192.98 9.27 154 304609 6456 110278080
Coordination abnormal 192.36 9.27 289 304474 24939 110259597
Palpitations 192.24 9.27 909 303854 158303 110126233
Rheumatoid factor positive 189.63 9.27 63 304700 131577 110152959
Motor dysfunction 183.84 9.27 278 304485 24128 110260408
Atrial tachycardia 183.05 9.27 172 304591 9006 110275530
Sensitisation 182.98 9.27 124 304639 4027 110280509
Sensory loss 178.34 9.27 256 304507 21201 110263335
Tinnitus 177.59 9.27 464 304299 60076 110224460
Eosinophilia 177.13 9.27 451 304312 57485 110227051
Tension headache 172.48 9.27 170 304593 9448 110275088
Hepatic enzyme increased 172.18 9.27 394 304369 320498 109964038
Carotid artery occlusion 171.41 9.27 169 304594 9396 110275140
Mobility decreased 169.89 9.27 244 304519 237178 110047358
Immunisation 166.93 9.27 106 304657 3077 110281459
End stage renal disease 166.60 9.27 248 304515 21225 110263311
Agranulocytosis 165.71 9.27 458 304305 61302 110223234
Inappropriate antidiuretic hormone secretion 165.36 9.27 318 304445 33533 110251003
Toxic skin eruption 161.67 9.27 280 304483 27235 110257301
Treatment failure 160.67 9.27 326 304437 276908 110007628
Sleep disorder due to general medical condition, insomnia type 160.35 9.27 46 304717 105597 110178939
Joint swelling 159.57 9.27 653 304110 442192 109842344
Blood cholesterol increased 156.24 9.27 167 304596 184618 110099918
Type 2 diabetes mellitus 155.70 9.27 155 304608 177077 110107459
Ill-defined disorder 153.57 9.27 124 304639 156729 110127807
Angioedema 153.12 9.27 607 304156 97893 110186643
Drug reaction with eosinophilia and systemic symptoms 152.72 9.27 536 304227 81559 110202977
Polycystic ovaries 151.37 9.27 117 304646 4679 110279857
Arterial occlusive disease 150.37 9.27 198 304565 15110 110269426
Joint range of motion decreased 149.95 9.27 74 304689 121758 110162778
Dysphagia 149.77 9.27 826 303937 152774 110131762
Deep vein thrombosis postoperative 148.44 9.27 3 304760 59288 110225248
Live birth 146.30 9.27 12 304751 69472 110215064
Gangrene 144.75 9.27 201 304562 16140 110268396
Hypokalaemia 144.43 9.27 929 303834 181519 110103017
Anosmia 144.23 9.27 175 304588 12297 110272239
Gait inability 143.56 9.27 100 304663 136276 110148260
Infusion related reaction 141.74 9.27 555 304208 380607 109903929
Pericarditis 140.78 9.27 242 304521 218872 110065664
Nightmare 138.53 9.27 321 304442 38542 110245994
Stomatitis 134.53 9.27 345 304418 269897 110014639
Impaired healing 132.19 9.27 211 304552 196506 110088030
Rash maculo-papular 131.56 9.27 477 304286 73745 110210791
Aphasia 130.99 9.27 409 304354 58588 110225948
Ejection fraction 129.61 9.27 88 304675 2867 110281669
Renal failure 129.44 9.27 1067 303696 225507 110059029
Eating disorder 128.19 9.27 271 304492 30587 110253949
Off label use 127.44 9.27 3157 301606 1497028 108787508
Alopecia 125.70 9.27 547 304216 364206 109920330
Peripheral venous disease 125.16 9.27 38 304725 84079 110200457
Drug abuse 124.28 9.27 185 304578 177226 110107310
Contraindicated product administered 121.99 9.27 319 304444 247948 110036588
Autoimmune disorder 121.01 9.27 18 304745 65465 110219071
Lower respiratory tract infection 120.50 9.27 311 304452 242795 110041741
Sinus congestion 120.21 9.27 262 304501 30197 110254339
Renal injury 119.98 9.27 198 304565 18515 110266021
Wound infection 118.09 9.27 59 304704 96406 110188130
Hemiparesis 117.20 9.27 325 304438 43578 110240958
Facial pain 115.92 9.27 175 304588 15164 110269372
Blepharospasm 114.03 9.27 10 304753 54841 110229695
Therapy non-responder 113.16 9.27 161 304602 157146 110127390
Grip strength decreased 112.64 9.27 40 304723 80134 110204402
Respiratory tract congestion 111.22 9.27 256 304507 30601 110253935
Weight increased 110.48 9.27 690 304073 418954 109865582
Liver injury 106.17 9.27 156 304607 150257 110134279
Lower limb fracture 105.16 9.27 38 304725 75310 110209226
Sleep disorder 104.80 9.27 246 304517 198398 110086138
Hyperkalaemia 104.72 9.27 687 304076 135109 110149427
Pancreatitis acute 102.31 9.27 382 304381 59892 110224644
Subarachnoid haemorrhage 102.23 9.27 242 304521 29460 110255076
Loss of employment 102.12 9.27 80 304683 3264 110281272
Hypergastrinaemia 101.94 9.27 38 304725 318 110284218
Pregnancy 101.72 9.27 11 304752 51056 110233480
Cardiac failure 101.52 9.27 873 303890 186753 110097783
Nephrogenic anaemia 101.45 9.27 91 304672 4486 110280050
Adjustment disorder with depressed mood 100.03 9.27 5 304758 43878 110240658
Nail disorder 98.14 9.27 20 304743 57915 110226621
Muscle spasticity 97.98 9.27 268 304495 35647 110248889
Night sweats 97.49 9.27 136 304627 133847 110150689
Onychomadesis 95.82 9.27 8 304755 45655 110238881
Swollen tongue 93.81 9.27 372 304391 59990 110224546
Diplopia 93.52 9.27 291 304472 41603 110242933
Acute generalised exanthematous pustulosis 93.18 9.27 193 304570 21471 110263065
Bone erosion 92.33 9.27 10 304753 46361 110238175
Sciatica 89.24 9.27 74 304689 92325 110192211
Angina pectoris 88.96 9.27 374 304389 61921 110222615
Cataract 88.84 9.27 444 304319 79041 110205495
Multi-organ disorder 88.67 9.27 74 304689 3307 110281229
Dislocation of vertebra 88.16 9.27 9 304754 43712 110240824
X-ray abnormal 87.99 9.27 4 304759 38113 110246423
Sneezing 87.59 9.27 239 304524 31745 110252791
Prescribed overdose 87.27 9.27 68 304695 87513 110197023
Hypercholesterolaemia 86.20 9.27 74 304689 90763 110193773
Bursitis 85.72 9.27 141 304622 129777 110154759
Impaired work ability 84.24 9.27 209 304554 26210 110258326
Sinus disorder 84.14 9.27 239 304524 32489 110252047
Therapeutic product effect decreased 83.14 9.27 368 304395 243948 110040588
Rhinitis 82.31 9.27 188 304575 22357 110262179
Pain of skin 82.15 9.27 175 304588 19854 110264682
Hypoaesthesia 81.97 9.27 518 304245 313705 109970831
Drug interaction 81.33 9.27 1877 302886 498306 109786230
Gamma-glutamyltransferase increased 80.59 9.27 359 304404 60950 110223586
Catarrh 80.10 9.27 100 304663 7235 110277301
Lupus vulgaris 80.07 9.27 3 304760 33880 110250656
Hip arthroplasty 79.86 9.27 27 304736 55786 110228750
Burns second degree 77.47 9.27 101 304662 7632 110276904
Coeliac disease 77.25 9.27 13 304750 43174 110241362
Myelosuppression 76.70 9.27 88 304675 94252 110190284
Skin haemorrhage 76.63 9.27 194 304569 24633 110259903
Respiratory syncytial virus test positive 76.48 9.27 49 304714 1445 110283091
Human rhinovirus test positive 76.43 9.27 46 304717 1211 110283325
Gastric polyps 76.43 9.27 85 304678 5438 110279098
Road traffic accident 76.16 9.27 111 304652 107287 110177249
Ventricular tachycardia 75.95 9.27 306 304457 49703 110234833
Blindness 75.19 9.27 246 304517 36113 110248423
Systemic lupus erythematosus rash 73.91 9.27 54 304709 1981 110282555
Contusion 73.78 9.27 361 304402 233000 110051536
Knee arthroplasty 73.28 9.27 44 304719 64904 110219632
Rhabdomyolysis 73.05 9.27 575 304188 119826 110164710
Eczema 72.60 9.27 392 304371 71901 110212635
Sleep apnoea syndrome 72.56 9.27 261 304502 40186 110244350
Condition aggravated 70.28 9.27 1517 303246 733319 109551217
Disturbance in attention 69.77 9.27 347 304416 61648 110222888
Hypopnoea 69.74 9.27 118 304645 11262 110273274
Product use in unapproved indication 68.91 9.27 845 303918 446532 109838004
Hypertensive nephropathy 68.38 9.27 40 304723 998 110283538
Wheezing 67.97 9.27 418 304345 254812 110029724
Bronchial neoplasm 67.90 9.27 32 304731 504 110284032
Nephrectomy 67.62 9.27 57 304706 2583 110281953
Drug intolerance 67.17 9.27 756 304007 405756 109878780
Hepatojugular reflux 66.76 9.27 35 304728 700 110283836
Malnutrition 66.07 9.27 195 304568 27084 110257452
Drug resistance 65.29 9.27 37 304726 56337 110228199
Rheumatoid nodule 65.17 9.27 161 304602 20135 110264401
Hiatus hernia 64.65 9.27 195 304568 27411 110257125
Occult blood 64.59 9.27 48 304715 1808 110282728
Anaemia 64.40 9.27 1968 302795 545118 109739418
Presbyacusis 64.37 9.27 57 304706 2762 110281774
Transient ischaemic attack 63.62 9.27 346 304417 63636 110220900
Rash papular 62.63 9.27 193 304570 27446 110257090
Diarrhoea 62.57 9.27 3784 300979 1135721 109148815
Cross sensitivity reaction 62.57 9.27 77 304686 5490 110279046
Taste disorder 62.36 9.27 53 304710 65334 110219202
Onychomycosis 61.84 9.27 15 304748 38516 110246020
Tenosynovitis stenosans 61.50 9.27 62 304701 3541 110280995
Viral test positive 60.93 9.27 35 304728 843 110283693
Vasculitis 60.58 9.27 227 304536 35646 110248890
Rhinitis allergic 60.57 9.27 145 304618 17777 110266759
Steroid dependence 60.31 9.27 94 304669 8375 110276161
Epigastric discomfort 59.98 9.27 97 304666 8918 110275618
Rhinorrhoea 59.93 9.27 486 304277 102180 110182356
Vertigo 59.54 9.27 427 304336 86443 110198093
Dermatitis bullous 59.43 9.27 142 304621 17387 110267149
Finger deformity 59.10 9.27 10 304753 33082 110251454
Arthritis 59.01 9.27 714 304049 166872 110117664
Hyperhidrosis 58.73 9.27 781 303982 186517 110098019
Jaundice 58.67 9.27 320 304443 58916 110225620
Iron deficiency anaemia 58.63 9.27 206 304557 31353 110253183
Dysphonia 58.44 9.27 384 304379 75545 110208991
Musculoskeletal stiffness 57.72 9.27 493 304270 279329 110005207
Musculoskeletal pain 57.34 9.27 284 304479 182739 110101797
Hepatic cytolysis 56.28 9.27 300 304463 54753 110229783
Nephropathy 55.62 9.27 118 304645 13349 110271187
Electrocardiogram Q wave abnormal 55.25 9.27 31 304732 713 110283823
Liver function test increased 54.85 9.27 100 304663 88448 110196088
Carpal tunnel syndrome 54.16 9.27 161 304602 22449 110262087
Drug eruption 53.90 9.27 291 304472 53368 110231168
Fibromyalgia 53.08 9.27 266 304497 170643 110113893
Osteoarthritis 52.94 9.27 291 304472 182332 110102204
Lactic acidosis 52.91 9.27 437 304326 92374 110192162
Cholangitis 52.90 9.27 130 304633 16205 110268331
Hypothyroidism 52.70 9.27 363 304400 72536 110212000
Ejection fraction abnormal 52.68 9.27 56 304707 3404 110281132
Disease progression 52.57 9.27 425 304338 243609 110040927
Cell death 52.44 9.27 72 304691 5719 110278817
Pleural fibrosis 52.36 9.27 62 304701 4246 110280290
Dysarthria 52.27 9.27 404 304359 83717 110200819
Back injury 52.24 9.27 33 304730 47366 110237170
Renal disorder 52.21 9.27 272 304491 49207 110235329
Gingival pain 51.77 9.27 126 304637 15610 110268926
Pleural thickening 51.73 9.27 55 304708 3344 110281192
Drug hypersensitivity 51.37 9.27 911 303852 453179 109831357
Eye pruritus 50.93 9.27 202 304561 32573 110251963
Infection 50.64 9.27 698 304065 361502 109923034
Parosmia 49.33 9.27 111 304652 13069 110271467
Hepatic function abnormal 49.07 9.27 417 304346 88878 110195658
Nasal turbinate hypertrophy 49.04 9.27 30 304733 814 110283722
Endometrial ablation 48.30 9.27 31 304732 917 110283619
Anaemia macrocytic 47.80 9.27 78 304685 7225 110277311
Vascular purpura 47.04 9.27 55 304708 3716 110280820
Degenerative mitral valve disease 46.15 9.27 21 304742 304 110284232
Muscle twitching 46.12 9.27 184 304579 29751 110254785
Subacute cutaneous lupus erythematosus 45.09 9.27 62 304701 4932 110279604
Pneumonia haemophilus 45.03 9.27 46 304717 2669 110281867
Cough 44.65 9.27 1623 303140 460018 109824518
Ischaemic stroke 44.35 9.27 228 304535 41035 110243501
Device expulsion 44.10 9.27 15 304748 30876 110253660
Hallucination 43.84 9.27 450 304313 100982 110183554
Synovial fluid analysis 43.70 9.27 45 304718 2636 110281900
Nephrolithiasis 43.39 9.27 322 304441 65890 110218646
Systolic dysfunction 43.20 9.27 57 304706 4358 110280178
Adverse event 42.61 9.27 155 304608 108654 110175882
Thrombocytopenia 42.60 9.27 1261 303502 347624 109936912
No adverse event 42.59 9.27 87 304676 73752 110210784
Pain 42.48 9.27 2175 302588 952780 109331756
Fall 42.33 9.27 2051 302712 601431 109683105
Laryngitis 42.16 9.27 33 304730 42378 110242158
Osteopenia 42.15 9.27 146 304617 22063 110262473
Pancreatic steatosis 41.92 9.27 37 304726 1785 110282751
Urticaria 41.91 9.27 622 304141 318235 109966301
Renal impairment 41.81 9.27 741 304022 187704 110096832
Dry mouth 41.79 9.27 351 304412 199597 110084939
Gastritis 41.58 9.27 272 304491 53427 110231109
Blood magnesium increased 41.56 9.27 52 304711 3771 110280765
Febrile bone marrow aplasia 41.49 9.27 124 304639 17341 110267195
Cardiac arrest 40.85 9.27 346 304417 196407 110088129
Abdominal pain upper 40.79 9.27 1255 303508 347856 109936680
Cerebrovascular accident 40.63 9.27 714 304049 180570 110103966
Normal newborn 40.50 9.27 6 304757 21890 110262646
Phlebitis 40.38 9.27 86 304677 9755 110274781
Dehydration 40.25 9.27 1032 303731 278479 110006057
Hepatocellular carcinoma 40.14 9.27 86 304677 9794 110274742
Therapy interrupted 39.93 9.27 47 304716 49775 110234761
Bronchial haemorrhage 39.82 9.27 32 304731 1355 110283181
Walking aid user 39.78 9.27 10 304753 25065 110259471
Headache 39.68 9.27 2882 301881 879495 109405041
Disability 39.28 9.27 17 304746 30206 110254330
Dry eye 39.25 9.27 276 304487 55517 110229019
Muscle haemorrhage 39.18 9.27 69 304694 6800 110277736
Respiratory distress 39.09 9.27 324 304439 68550 110215986
Septic shock 38.80 9.27 630 304133 156898 110127638
Shock haemorrhagic 38.44 9.27 163 304600 27084 110257452
Eye haemorrhage 38.44 9.27 94 304669 11680 110272856
Laboratory test abnormal 38.18 9.27 39 304724 44040 110240496
Mixed liver injury 37.92 9.27 95 304668 11984 110272552
Pericardial effusion 37.92 9.27 279 304484 56938 110227598
Therapy partial responder 37.91 9.27 28 304735 37033 110247503
Electric shock 37.88 9.27 35 304728 1793 110282743
Idiopathic pulmonary fibrosis 37.68 9.27 57 304706 4947 110279589
Cerebral haematoma 37.04 9.27 82 304681 9550 110274986
Crepitations 36.98 9.27 88 304675 10747 110273789
Sudden death 36.82 9.27 149 304614 24246 110260290
Hepatic encephalopathy 36.78 9.27 165 304598 28091 110256445
General physical health deterioration 36.62 9.27 892 303871 424403 109860133
Urate nephropathy 36.56 9.27 16 304747 210 110284326
Muscular weakness 36.54 9.27 920 303843 247548 110036988
Bunion operation 36.50 9.27 26 304737 916 110283620
Lip swelling 36.44 9.27 252 304511 50415 110234121
Immunodeficiency 36.40 9.27 32 304731 38806 110245730
Brain scan abnormal 36.34 9.27 32 304731 1539 110282997
Gastric adenoma 36.06 9.27 9 304754 13 110284523
Face oedema 36.01 9.27 185 304578 33284 110251252
Altered state of consciousness 35.93 9.27 277 304486 57349 110227187
Vitamin B12 deficiency 35.77 9.27 83 304680 9972 110274564
Cholestatic liver injury 35.66 9.27 69 304694 7307 110277229
Acquired haemophilia 35.56 9.27 40 304723 2591 110281945
Lupus-like syndrome 35.43 9.27 36 304727 40756 110243780
Chronic kidney disease-mineral and bone disorder 35.35 9.27 22 304741 616 110283920
Pulmonary valve disease 35.21 9.27 18 304745 341 110284195
Occupational dermatitis 34.60 9.27 14 304749 149 110284387
Cystitis 34.51 9.27 305 304458 65731 110218805
Thyroid disorder 34.36 9.27 114 304649 16855 110267681
Scleritis 34.28 9.27 57 304706 5363 110279173
Product dose omission issue 34.04 9.27 653 304110 321129 109963407
Malaise 33.97 9.27 2216 302547 669603 109614933
Aggression 33.94 9.27 70 304693 59140 110225396
Synovial cyst 33.91 9.27 88 304675 11342 110273194
Bronchial disorder 33.82 9.27 40 304723 2736 110281800
Intentional overdose 33.71 9.27 220 304543 132281 110152255
Lymphatic fistula 33.68 9.27 30 304733 1465 110283071
Swelling face 33.66 9.27 396 304367 91925 110192611
Inferior vena cava dilatation 33.63 9.27 25 304738 942 110283594
Hypersensitivity 33.51 9.27 852 303911 403146 109881390
Device dependence 33.37 9.27 11 304752 61 110284475
Hepatitis cholestatic 32.92 9.27 115 304648 17451 110267085
Treatment noncompliance 32.70 9.27 98 304665 72892 110211644
Enterocolitis 32.07 9.27 120 304643 18829 110265707
Osteosclerosis 31.99 9.27 50 304713 4465 110280071
Drug tolerance 31.96 9.27 4 304759 16581 110267955
Femoral hernia incarcerated 31.48 9.27 29 304734 1480 110283056
Drug dependence 31.41 9.27 56 304707 49964 110234572
Product use issue 31.31 9.27 638 304125 311057 109973479
Nasopharyngitis 31.30 9.27 837 303926 393524 109891012
Physical examination abnormal 31.01 9.27 19 304744 517 110284019
Pulmonary arterial hypertension 30.95 9.27 174 304589 32394 110252142
Cerebral artery thrombosis 30.87 9.27 30 304733 1638 110282898
Carotid arteriosclerosis 30.74 9.27 40 304723 3017 110281519
Nausea 30.71 9.27 3870 300893 1231820 109052716
Lip oedema 30.70 9.27 66 304697 7534 110277002
Erythema dyschromicum perstans 30.49 9.27 11 304752 83 110284453
Radiation pneumonitis 30.44 9.27 49 304714 4487 110280049
Tongue biting 30.40 9.27 39 304724 2900 110281636
Influenza like illness 30.38 9.27 375 304388 88037 110196499
Product quality issue 30.34 9.27 110 304653 77189 110207347
Melaena 30.17 9.27 306 304457 68451 110216085
Dermatitis exfoliative generalised 30.05 9.27 82 304681 10890 110273646
Eructation 29.87 9.27 96 304667 13961 110270575
Colitis microscopic 29.86 9.27 93 304670 13301 110271235
Immune-mediated hepatic disorder 29.77 9.27 48 304715 4402 110280134
Ear infection 29.73 9.27 82 304681 62650 110221886
Accidental exposure to product 29.63 9.27 58 304705 49950 110234586
Ulcer 29.58 9.27 212 304551 42904 110241632
Post cholecystectomy syndrome 29.57 9.27 22 304741 830 110283706
Nephrosclerosis 29.52 9.27 32 304731 1989 110282547
Mental status changes 29.43 9.27 109 304654 76013 110208523
Tumour fistulisation 29.15 9.27 12 304751 134 110284402
Helicobacter gastritis 29.10 9.27 36 304727 2580 110281956
Accidental overdose 28.97 9.27 243 304520 51591 110232945
Ventricular hypokinesia 28.93 9.27 82 304681 11132 110273404
Deformity 28.90 9.27 77 304686 10083 110274453
Neurosis 28.76 9.27 19 304744 591 110283945
Incorrect route of product administration 28.70 9.27 86 304677 63975 110220561
Depression 28.57 9.27 661 304102 316674 109967862
Nerve injury 28.29 9.27 79 304684 10634 110273902
Pericardial disease 28.12 9.27 20 304743 703 110283833
Nipple swelling 28.02 9.27 16 304747 381 110284155
Food allergy 27.93 9.27 10 304753 19938 110264598
Diabetic nephropathy 27.91 9.27 41 304722 3467 110281069
Acute coronary syndrome 27.89 9.27 132 304631 22980 110261556
Eosinophilic colitis 27.85 9.27 19 304744 624 110283912
Paraesthesia 27.48 9.27 567 304196 275954 110008582
Administration site inflammation 27.44 9.27 10 304753 78 110284458
Oedema 27.44 9.27 410 304353 209566 110074970
Alcohol poisoning 27.34 9.27 70 304693 8950 110275586
Electrocardiogram QT prolonged 27.28 9.27 437 304326 108523 110176013
Drug use disorder 27.18 9.27 8 304755 18066 110266470
Pulmonary vascular disorder 27.18 9.27 23 304740 1048 110283488
Nephritic syndrome 26.85 9.27 17 304746 491 110284045
Blood test abnormal 26.77 9.27 152 304611 28402 110256134
Dry skin 26.67 9.27 431 304332 107222 110177314
Peripheral swelling 26.48 9.27 880 303883 403154 109881382
Renal tubular disorder 26.07 9.27 61 304702 7368 110277168
Fatigue 26.05 9.27 2944 301819 1213014 109071522
Multiple-drug resistance 25.98 9.27 3 304760 13232 110271304
Axonal neuropathy 25.95 9.27 32 304731 2286 110282250
Cholecystitis acute 25.93 9.27 99 304664 15683 110268853
Intentional product use issue 25.93 9.27 504 304259 247402 110037134
Neurotoxicity 25.84 9.27 48 304715 42159 110242377
Amniotic fluid index increased 25.81 9.27 10 304753 94 110284442
Emotional distress 25.72 9.27 53 304710 44794 110239742
Haematotoxicity 25.64 9.27 13 304750 21069 110263467
Respiratory arrest 25.59 9.27 79 304684 58220 110226316
Troponin T increased 25.53 9.27 44 304719 4262 110280274
Vitreous detachment 25.45 9.27 34 304729 2631 110281905
Gallbladder polyp 25.44 9.27 24 304739 1263 110283273
Macular degeneration 25.39 9.27 14 304749 21645 110262891
Photophobia 25.37 9.27 139 304624 25632 110258904
Inflammation 25.36 9.27 377 304386 192861 110091675
Neuroleptic malignant syndrome 25.34 9.27 34 304729 34025 110250511
Oesophageal ulcer haemorrhage 25.30 9.27 21 304742 931 110283605
Allergy to chemicals 25.22 9.27 38 304725 3287 110281249
Pneumobilia 25.19 9.27 14 304749 316 110284220
Injection site pain 25.15 9.27 342 304421 177580 110106956
Memory impairment 24.89 9.27 387 304376 196557 110087979
Nasal discharge discolouration 24.87 9.27 37 304726 3164 110281372
Hyperuricaemia 24.57 9.27 92 304671 14439 110270097
Sedation complication 24.51 9.27 12 304751 19843 110264693
Anaemia vitamin B12 deficiency 24.48 9.27 23 304740 1204 110283332
Helicobacter test positive 24.42 9.27 24 304739 1329 110283207
Foetal death 24.32 9.27 7 304756 16038 110268498
Mesenteric panniculitis 24.27 9.27 17 304746 583 110283953
Pulmonary fibrosis 24.18 9.27 173 304590 101869 110182667
Injection site erythema 24.14 9.27 156 304607 94020 110190516
Granulomatous rosacea 24.12 9.27 12 304751 214 110284322
Hypoparathyroidism secondary 24.10 9.27 13 304750 276 110284260
Occupational exposure to air contaminants 24.06 9.27 11 304752 161 110284375
Hyperparathyroidism secondary 23.98 9.27 37 304726 3267 110281269
Arterial haemorrhage 23.93 9.27 40 304723 3779 110280757
Duodenal polyp 23.90 9.27 16 304747 509 110284027
Chest discomfort 23.89 9.27 638 304125 173210 110111326
Hyperthermia 23.88 9.27 119 304644 21153 110263383
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 23.87 9.27 9 304754 78 110284458
Cutaneous lupus erythematosus 23.85 9.27 38 304725 3450 110281086
Psychotic disorder 23.83 9.27 67 304696 50870 110233666
Cerebral haemorrhage 23.82 9.27 279 304484 64689 110219847
Pancreatic neuroendocrine tumour 23.79 9.27 20 304743 903 110283633
Hypoparathyroidism 23.72 9.27 25 304738 1505 110283031
Gastrointestinal motility disorder 23.66 9.27 58 304705 7218 110277318
Product used for unknown indication 23.44 9.27 28 304735 1935 110282601
Wound infection pseudomonas 23.39 9.27 31 304732 2380 110282156
Cerebral infarction 23.37 9.27 232 304531 51606 110232930
Mouth haemorrhage 23.31 9.27 86 304677 13402 110271134
Red blood cell sedimentation rate abnormal 23.21 9.27 20 304743 24489 110260047
Ureteric compression 23.09 9.27 13 304750 301 110284235
Intervertebral discitis 23.03 9.27 56 304707 6934 110277602
Aspartate aminotransferase 22.94 9.27 20 304743 949 110283587
Bone cyst 22.93 9.27 38 304725 3565 110280971
Eosinophilic fasciitis 22.78 9.27 14 304749 383 110284153
Exposure to toxic agent 22.71 9.27 4 304759 12854 110271682
Exostosis 22.59 9.27 59 304704 45897 110238639
Kidney infection 22.52 9.27 134 304629 25465 110259071
Hyperkinetic heart syndrome 22.40 9.27 10 304753 138 110284398
Pyelocaliectasis 22.37 9.27 21 304742 1098 110283438
Premature delivery 22.37 9.27 31 304732 30601 110253935
Vulvovaginal burning sensation 22.26 9.27 28 304735 2041 110282495
Hypoosmolar state 22.09 9.27 14 304749 405 110284131
Eyelid oedema 22.07 9.27 92 304671 15170 110269366
Glomerular filtration rate increased 22.02 9.27 27 304736 1918 110282618
Mast cell activation syndrome 21.98 9.27 24 304739 1504 110283032
Hunger 21.85 9.27 53 304710 6551 110277985
Gait disturbance 21.66 9.27 592 304171 277616 110006920
Rectosigmoid cancer 21.57 9.27 13 304750 343 110284193
Angina bullosa haemorrhagica 21.54 9.27 11 304752 208 110284328
Rash 21.47 9.27 1959 302804 819005 109465531
Nerve degeneration 21.46 9.27 12 304751 274 110284262
Skin ulcer 21.45 9.27 269 304494 63376 110221160
Salpingo-oophorectomy unilateral 21.40 9.27 18 304745 813 110283723
Seizure 21.24 9.27 456 304307 220729 110063807
Tongue injury 21.23 9.27 16 304747 616 110283920
Hypovitaminosis 21.12 9.27 23 304740 1437 110283099
Nicotine dependence 21.08 9.27 22 304741 1309 110283227
Urticaria papular 21.04 9.27 12 304751 285 110284251
Cardiac aneurysm 21.02 9.27 25 304738 1720 110282816
Dermatitis exfoliative 21.02 9.27 74 304689 11273 110273263
Allergic keratitis 20.87 9.27 6 304757 19 110284517
Haematemesis 20.86 9.27 252 304511 58856 110225680
Respiratory depression 20.85 9.27 35 304728 31966 110252570
Haematuria 20.82 9.27 333 304430 82672 110201864
Urinary retention 20.77 9.27 288 304475 69395 110215141
Hypoalbuminaemia 20.77 9.27 144 304619 28830 110255706
Deafness neurosensory 20.72 9.27 66 304697 9553 110274983
Heat stroke 20.52 9.27 26 304737 1909 110282627
Rebound acid hypersecretion 20.51 9.27 9 304754 119 110284417
Product substitution issue 20.47 9.27 121 304642 22940 110261596
Tetany 20.29 9.27 36 304727 3568 110280968
Spontaneous haematoma 20.25 9.27 26 304737 1935 110282601
Burning sensation 20.21 9.27 285 304478 68927 110215609
Bradypnoea 20.16 9.27 61 304702 8588 110275948
Gastric disorder 20.05 9.27 159 304604 33198 110251338
Photosensitivity reaction 20.04 9.27 130 304633 25459 110259077
Genital infection female 20.04 9.27 8 304755 82 110284454
Clinically isolated syndrome 19.98 9.27 7 304756 48 110284488
Dysgeusia 19.96 9.27 287 304476 69698 110214838
Subdural haematoma 19.89 9.27 170 304593 36284 110248252
Dizziness 19.88 9.27 1655 303108 696538 109587998
Antinuclear antibody positive 19.83 9.27 63 304700 9105 110275431
Pharyngeal necrosis 19.62 9.27 8 304755 87 110284449
Erythema multiforme 19.58 9.27 112 304651 20985 110263551
Hyperphosphatasaemia 19.55 9.27 9 304754 134 110284402
Skin exfoliation 19.55 9.27 345 304418 87306 110197230
Oesophagitis ulcerative 19.34 9.27 23 304740 1582 110282954
Vitamin B12 increased 19.29 9.27 26 304737 2029 110282507
Hepatic haematoma 19.08 9.27 18 304745 947 110283589
Escherichia pyelonephritis 19.05 9.27 18 304745 949 110283587
Foetal macrosomia 18.99 9.27 8 304755 95 110284441
Insulin autoimmune syndrome 18.96 9.27 16 304747 726 110283810
Aortic valve stenosis 18.95 9.27 49 304714 6301 110278235
Diverticulum intestinal 18.83 9.27 73 304690 11646 110272890
Anticoagulation drug level increased 18.77 9.27 18 304745 967 110283569
Pustular psoriasis 18.75 9.27 7 304756 13598 110270938
Adverse reaction 18.70 9.27 33 304730 29561 110254975
Hepatitis fulminant 18.68 9.27 59 304704 8501 110276035
Anuria 18.66 9.27 123 304640 24218 110260318
Faecaloma 18.62 9.27 86 304677 14822 110269714
Cardiac murmur 18.61 9.27 124 304639 24504 110260032
Tooth disorder 18.48 9.27 142 304621 29367 110255169
Abortion spontaneous 18.43 9.27 42 304721 34240 110250296
Erythema 18.43 9.27 981 303782 290466 109994070
Drug effective for unapproved indication 18.36 9.27 8 304755 14159 110270377
Haemarthrosis 18.33 9.27 53 304710 7276 110277260
Cardiotoxicity 18.26 9.27 12 304751 16869 110267667
Acute hepatitis B 18.26 9.27 14 304749 553 110283983
Adenovirus infection 18.20 9.27 4 304759 10990 110273546
IIIrd nerve paresis 18.18 9.27 10 304753 221 110284315
Capillary permeability increased 18.14 9.27 7 304756 65 110284471
Blood immunoglobulin A increased 18.13 9.27 22 304741 1546 110282990
Ventricular fibrillation 18.12 9.27 56 304707 41257 110243279
Gastric cancer 18.04 9.27 69 304694 10939 110273597
Gastroenteritis eosinophilic 18.00 9.27 12 304751 379 110284157
Large intestine polyp 18.00 9.27 86 304677 15031 110269505
Thrombocytopenic purpura 17.95 9.27 31 304732 3008 110281528
Blood alkaline phosphatase increased 17.95 9.27 285 304478 70650 110213886
Product complaint 17.94 9.27 8 304755 13964 110270572
Phaeochromocytoma malignant 17.86 9.27 7 304756 68 110284468
Pneumonia aspiration 17.85 9.27 319 304444 80914 110203622
Abdominal discomfort 17.83 9.27 895 303868 392963 109891573
Appendicitis 17.75 9.27 32 304731 28432 110256104
Muscle spasms 17.47 9.27 609 304154 277548 110006988
Blood parathyroid hormone decreased 17.46 9.27 77 304686 13012 110271524
Seroma 17.35 9.27 32 304731 3269 110281267
Injection site haemorrhage 17.33 9.27 41 304722 32987 110251549
Schizophreniform disorder 17.26 9.27 9 304754 178 110284358
Ventricular enlargement 17.26 9.27 15 304748 709 110283827
Tongue oedema 17.19 9.27 56 304707 8200 110276336
Pulmonary hypertension 17.19 9.27 230 304533 54990 110229546
Prescription form tampering 17.08 9.27 13 304750 508 110284028
Haematoma muscle 17.08 9.27 36 304727 4054 110280482
Post transplant lymphoproliferative disorder 17.03 9.27 11 304752 15602 110268934
Cardiothoracic ratio increased 17.02 9.27 7 304756 78 110284458
Cerebellar haematoma 16.88 9.27 14 304749 620 110283916
Hyperkaliuria 16.86 9.27 9 304754 187 110284349
Heart rate increased 16.76 9.27 517 304246 143317 110141219
Intestinal obstruction 16.69 9.27 222 304541 53005 110231531
Lichen planus 16.61 9.27 32 304731 3378 110281158
Purging 16.55 9.27 6 304757 46 110284490
Small cell carcinoma 16.54 9.27 11 304752 346 110284190
Injection site swelling 16.53 9.27 101 304662 61689 110222847
Hypertriglyceridaemia 16.49 9.27 88 304675 16066 110268470
Vaginal discharge 16.49 9.27 15 304748 17893 110266643
Bacterial infection 16.47 9.27 68 304695 45968 110238568
Cardiac discomfort 16.45 9.27 20 304743 1408 110283128
Influenza 16.43 9.27 595 304168 168506 110116030
Hepatic cyst 16.40 9.27 53 304710 7730 110276806
Neutropenic sepsis 16.26 9.27 38 304725 30708 110253828
Fixed eruption 16.24 9.27 36 304727 4196 110280340
Substance abuse 16.21 9.27 7 304756 12456 110272080
Papillary renal cell carcinoma 16.21 9.27 11 304752 358 110284178
High frequency ablation 16.18 9.27 11 304752 359 110284177
Unresponsive to stimuli 16.18 9.27 106 304657 63684 110220852
Cerebellar syndrome 16.18 9.27 46 304717 6256 110278280
Muscle contractions involuntary 16.16 9.27 37 304726 4407 110280129
Diverticulum oesophageal 16.16 9.27 9 304754 204 110284332
Anxiety 16.11 9.27 1131 303632 343947 109940589
Cardiorenal syndrome 16.11 9.27 23 304740 1895 110282641
Pathogen resistance 16.04 9.27 15 304748 17657 110266879
Campylobacter gastroenteritis 16.01 9.27 23 304740 1906 110282630
Creatinine renal clearance decreased 16.00 9.27 22 304741 21793 110262743
Underdose 15.92 9.27 106 304657 63448 110221088
Persistent depressive disorder 15.91 9.27 20 304743 1457 110283079
Device difficult to use 15.88 9.27 17 304746 18788 110265748
Purple glove syndrome 15.85 9.27 10 304753 287 110284249
Gastric antral vascular ectasia 15.84 9.27 18 304745 1179 110283357
Blood glucose increased 15.63 9.27 477 304286 132019 110152517
Mesenteric artery stenosis 15.59 9.27 5 304758 25 110284511
Cardiac disorder 15.53 9.27 296 304467 75984 110208552
Organising pneumonia 15.51 9.27 79 304684 14164 110270372
Food interaction 15.48 9.27 24 304739 2128 110282408
Dermatophytosis of nail 15.43 9.27 10 304753 301 110284235
Occupational exposure to product 15.36 9.27 15 304748 824 110283712
Pyrexia 15.35 9.27 2755 302008 895510 109389026
Ulcer haemorrhage 15.35 9.27 24 304739 22547 110261989
Hyperchlorhydria 15.34 9.27 24 304739 2145 110282391
Tubulointerstitial nephritis and uveitis syndrome 15.26 9.27 11 304752 395 110284141
Pleurisy 15.21 9.27 70 304693 12046 110272490
Dyspnoea at rest 15.09 9.27 54 304709 8292 110276244
Nasal congestion 15.06 9.27 366 304397 97916 110186620
Teeth brittle 15.05 9.27 13 304750 609 110283927
Cognitive disorder 14.99 9.27 331 304432 87180 110197356
Transplant rejection 14.98 9.27 28 304735 24539 110259997
Cushingoid 14.95 9.27 68 304695 11644 110272892
Campylobacter colitis 14.92 9.27 7 304756 109 110284427
Oesophageal adenocarcinoma 14.91 9.27 16 304747 983 110283553
Venoocclusive liver disease 14.90 9.27 12 304751 15195 110269341
Small intestine ulcer 14.89 9.27 15 304748 856 110283680
Pancreatitis 14.84 9.27 350 304413 93183 110191353
Cholecystitis 14.82 9.27 122 304641 25760 110258776
Wound dehiscence 14.81 9.27 52 304711 7910 110276626
Gastrointestinal haemorrhage 14.79 9.27 577 304186 164941 110119595
Sickle cell anaemia with crisis 14.77 9.27 4 304759 9541 110274995
Pemphigoid 14.76 9.27 99 304664 19608 110264928
Vulvovaginal pruritus 14.71 9.27 30 304733 3301 110281235
Febrile neutropenia 14.69 9.27 718 304045 316049 109968487
Nipple pain 14.65 9.27 17 304746 1139 110283397
Circumoral oedema 14.56 9.27 11 304752 425 110284111
COVID-19 14.53 9.27 820 303943 244240 110040296
Tricuspid valve incompetence 14.46 9.27 114 304649 23759 110260777
Platelet count decreased 14.43 9.27 775 303988 229668 110054868
Myoglobinaemia 14.42 9.27 8 304755 180 110284356
Ocular myasthenia 14.41 9.27 14 304749 764 110283772
Supraventricular extrasystoles 14.40 9.27 52 304711 8021 110276515
Tenosynovitis 14.18 9.27 85 304678 16198 110268338
Echocardiogram abnormal 14.15 9.27 26 304737 2648 110281888
Granulocyte count increased 14.11 9.27 22 304741 1961 110282575
Haematoma 14.07 9.27 233 304530 58243 110226293
Renal tubular necrosis 14.03 9.27 137 304626 30338 110254198
Ventricular arrhythmia 13.96 9.27 60 304703 10027 110274509
Ingrowing nail 13.96 9.27 29 304734 3233 110281303
Cytomegalovirus infection reactivation 13.95 9.27 18 304745 18315 110266221
Left-to-right cardiac shunt 13.92 9.27 8 304755 193 110284343
Miosis 13.89 9.27 106 304657 21877 110262659
Adrenocorticotropic hormone deficiency 13.87 9.27 23 304740 2159 110282377
Cardiac murmur functional 13.83 9.27 5 304758 38 110284498
Paraesthesia oral 13.83 9.27 47 304716 33624 110250912
Poisoning 13.82 9.27 38 304725 29067 110255469
Mucormycosis 13.78 9.27 6 304757 10622 110273914
Gastrointestinal submucosal tumour 13.77 9.27 7 304756 131 110284405
Rhonchi 13.63 9.27 35 304728 4483 110280053
Chest expansion decreased 13.52 9.27 8 304755 204 110284332
Mitral valve incompetence 13.52 9.27 146 304617 33183 110251353
Enterochromaffin cell hyperplasia 13.49 9.27 6 304757 82 110284454
Bicytopenia 13.46 9.27 45 304718 6679 110277857
Therapeutic response decreased 13.45 9.27 186 304577 96313 110188223
Epiglottic erythema 13.43 9.27 6 304757 83 110284453
Caesarean section 13.42 9.27 11 304752 13806 110270730
Localised infection 13.36 9.27 67 304696 42981 110241555
Immune reconstitution inflammatory syndrome 13.33 9.27 15 304748 16211 110268325
Upper respiratory tract inflammation 13.33 9.27 34 304729 4337 110280199
Pyelonephritis acute 13.33 9.27 47 304716 7166 110277370
Aspergillus infection 13.28 9.27 32 304731 25584 110258952
Pulseless electrical activity 13.22 9.27 16 304747 16741 110267795
Blood loss anaemia 13.17 9.27 90 304673 17935 110266601
Dental restoration failure 13.11 9.27 16 304747 1131 110283405
Injection site pruritus 13.09 9.27 85 304678 51173 110233363
Coma acidotic 13.09 9.27 7 304756 146 110284390
Illness 13.08 9.27 154 304609 82017 110202519
Craniocerebral injury 13.04 9.27 41 304722 5893 110278643
Flatulence 12.99 9.27 209 304554 51940 110232596
Thalamus haemorrhage 12.89 9.27 21 304742 1943 110282593
Hypomania 12.87 9.27 6 304757 10204 110274332
Mydriasis 12.87 9.27 26 304737 22131 110262405
Blood pressure diastolic decreased 12.67 9.27 153 304610 35732 110248804
Renal atrophy 12.65 9.27 23 304740 2323 110282213
Epilepsy 12.63 9.27 197 304566 100012 110184524
Hyperchloruria 12.62 9.27 3 304760 3 110284533
Hypermagnesuria 12.62 9.27 3 304760 3 110284533
Blood pressure increased 12.61 9.27 850 303913 257523 110027013
Type III immune complex mediated reaction 12.54 9.27 15 304748 1038 110283498
Bile duct stone 12.51 9.27 42 304721 6247 110278289
Hypocapnia 12.43 9.27 14 304749 908 110283628
Infusion site scar 12.39 9.27 10 304753 426 110284110
Hypercalcaemia 12.39 9.27 189 304574 46468 110238068
Pyelonephritis 12.36 9.27 115 304648 25135 110259401
Arterial spasm 12.28 9.27 7 304756 166 110284370
Feeling jittery 12.28 9.27 76 304687 14646 110269890
Ear pain 12.24 9.27 91 304672 53135 110231401
Hepatitis 12.22 9.27 330 304433 89724 110194812
Post-traumatic stress disorder 12.20 9.27 43 304720 6553 110277983
Hypertension 12.20 9.27 1225 303538 508859 109775677
Duodenitis 12.20 9.27 54 304709 9142 110275394
Muscle swelling 12.18 9.27 15 304748 1070 110283466
Seronegative arthritis 12.18 9.27 11 304752 13166 110271370
Premature labour 12.18 9.27 5 304758 9167 110275369
Therapy cessation 12.17 9.27 73 304690 44784 110239752
Angiopathy 12.14 9.27 52 304711 8678 110275858
Stoma site discharge 12.14 9.27 25 304738 2770 110281766
Lethargy 12.12 9.27 183 304580 93393 110191143
Mucosal inflammation 12.12 9.27 189 304574 95952 110188584
Type I hypersensitivity 12.11 9.27 42 304721 6351 110278185
Coronary artery stenosis 12.09 9.27 72 304691 13686 110270850
Infective exacerbation of chronic obstructive airways disease 12.09 9.27 27 304736 3163 110281373
On and off phenomenon 12.05 9.27 33 304730 4391 110280145
Renal infarct 12.05 9.27 28 304735 3367 110281169
Spinal disorder 12.05 9.27 64 304699 11664 110272872
Genotype drug resistance test positive 12.01 9.27 17 304746 1389 110283147
Adenocarcinoma gastric 12.01 9.27 21 304742 2058 110282478
Cytomegalovirus viraemia 11.97 9.27 19 304744 17745 110266791
Purpura 11.90 9.27 111 304652 24277 110260259
Placental calcification 11.87 9.27 4 304759 24 110284512
COVID-19 treatment 11.87 9.27 10 304753 453 110284083
Nocardiosis 11.85 9.27 3 304760 7483 110277053
Renal hypertension 11.83 9.27 8 304755 259 110284277
CSF volume increased 11.83 9.27 5 304758 60 110284476
Blood gastrin increased 11.75 9.27 5 304758 61 110284475
Thymus disorder 11.72 9.27 11 304752 575 110283961
Rash scarlatiniform 11.66 9.27 9 304754 359 110284177
Therapeutic embolisation 11.66 9.27 11 304752 579 110283957
Laryngopharyngitis 11.63 9.27 6 304757 116 110284420
Fear of injection 11.60 9.27 5 304758 8906 110275630
Coombs negative haemolytic anaemia 11.59 9.27 11 304752 583 110283953
Lichenoid keratosis 11.59 9.27 41 304722 6261 110278275
Brain injury 11.58 9.27 12 304751 13464 110271072
Hepatitis B DNA increased 11.56 9.27 13 304750 842 110283694
Tenderness 11.50 9.27 128 304635 29309 110255227
Suicide attempt 11.48 9.27 208 304555 103186 110181350
Oral pustule 11.46 9.27 8 304755 273 110284263
Skin lesion 11.43 9.27 203 304560 51428 110233108
Diabetes mellitus inadequate control 11.42 9.27 129 304634 29646 110254890
Alpha-1 anti-trypsin decreased 11.41 9.27 3 304760 6 110284530
Creatinine renal clearance abnormal 11.39 9.27 12 304751 722 110283814
Haemorrhagic stroke 11.38 9.27 71 304692 13718 110270818
Chronic obstructive pulmonary disease 11.38 9.27 222 304541 108936 110175600
Pulmonary congestion 11.36 9.27 133 304630 30833 110253703
Gastric dysplasia 11.35 9.27 4 304759 28 110284508
Acute pulmonary oedema 11.33 9.27 83 304680 16913 110267623
Hyponatraemic seizure 11.32 9.27 12 304751 727 110283809
Xerosis 11.32 9.27 18 304745 1631 110282905
Tumour haemorrhage 11.31 9.27 36 304727 5209 110279327
Dystonia 11.30 9.27 35 304728 25770 110258766
Postrenal failure 11.30 9.27 13 304750 863 110283673
Granulocytopenia 11.30 9.27 11 304752 12704 110271832
Chronic graft versus host disease 11.25 9.27 6 304757 9451 110275085
Distal intestinal obstruction syndrome 11.23 9.27 14 304749 1011 110283525
Vulvovaginal inflammation 11.19 9.27 12 304751 737 110283799
Atrioventricular block complete 11.14 9.27 94 304669 19988 110264548
Amaurosis fugax 11.12 9.27 22 304741 2368 110282168
Delirium 11.11 9.27 285 304478 134740 110149796
Microcytic anaemia 11.05 9.27 40 304723 6178 110278358
Pre-eclampsia 11.03 9.27 5 304758 8645 110275891
Peripheral artery stenosis 11.03 9.27 16 304747 1338 110283198
Benign soft tissue neoplasm 10.97 9.27 6 304757 131 110284405
Anal erythema 10.96 9.27 8 304755 293 110284243
Concomitant disease aggravated 10.96 9.27 80 304683 16284 110268252
Myalgia 10.92 9.27 732 304031 221649 110062887
Injection site reaction 10.92 9.27 176 304587 88894 110195642
Multiple injuries 10.90 9.27 28 304735 3586 110280950
Synovial disorder 10.89 9.27 25 304738 2982 110281554
Hyperglycaemic hyperosmolar nonketotic syndrome 10.88 9.27 25 304738 2984 110281552
Abnormal behaviour 10.87 9.27 63 304700 38976 110245560
Wheelchair user 10.86 9.27 4 304759 7838 110276698
Urinary bladder haemorrhage 10.82 9.27 24 304739 2798 110281738
Malignant neoplasm of unknown primary site 10.77 9.27 12 304751 769 110283767
Cardiac pacemaker evaluation 10.77 9.27 6 304757 136 110284400
Aortic dissection 10.76 9.27 34 304729 4899 110279637
Areflexia 10.74 9.27 42 304721 6727 110277809
Cancer pain 10.73 9.27 42 304721 6730 110277806
Haemobilia 10.71 9.27 11 304752 642 110283894
Infusion site thrombosis 10.66 9.27 8 304755 306 110284230
Heat illness 10.64 9.27 12 304751 780 110283756
Cholangitis acute 10.63 9.27 19 304744 1894 110282642
Prurigo 10.62 9.27 16 304747 1384 110283152
Adrenal insufficiency 10.60 9.27 170 304593 42220 110242316
Anastomotic ulcer 10.59 9.27 14 304749 1072 110283464
Pericardial haemorrhage 10.52 9.27 35 304728 5182 110279354
Toxic epidermal necrolysis 10.50 9.27 217 304546 56510 110228026
Conjunctival ulcer 10.48 9.27 5 304758 81 110284455
Hypocalciuria 10.48 9.27 4 304759 36 110284500
Stoma site erythema 10.48 9.27 20 304743 2097 110282439
Rheumatoid factor increased 10.40 9.27 22 304741 2483 110282053
Eye pain 10.40 9.27 195 304568 49904 110234632
Tarsal tunnel syndrome 10.40 9.27 10 304753 539 110283997
Fluid retention 10.38 9.27 190 304573 94117 110190419
Arteriovenous fistula site haematoma 10.38 9.27 4 304759 37 110284499
Rectal cancer metastatic 10.37 9.27 10 304753 541 110283995
Gallbladder disorder 10.33 9.27 27 304736 21002 110263534
Transplant dysfunction 10.33 9.27 5 304758 8323 110276213
Acute on chronic liver failure 10.32 9.27 9 304754 427 110284109
Gastric ulcer haemorrhage 10.31 9.27 55 304708 10039 110274497
Sinusitis fungal 10.28 9.27 23 304740 2697 110281839
Surgery 10.27 9.27 69 304694 41214 110243322
Dermatitis atopic 10.25 9.27 36 304727 25505 110259031
Rash pruritic 10.25 9.27 348 304415 97721 110186815
Sputum increased 10.22 9.27 37 304726 5714 110278822
Proteinuria 10.20 9.27 161 304602 39857 110244679
Hypovolaemic shock 10.17 9.27 72 304691 14511 110270025
Flank pain 10.17 9.27 103 304660 23027 110261509
Graft versus host disease in skin 10.17 9.27 5 304758 8249 110276287
Graft versus host disease 10.14 9.27 23 304740 18783 110265753
Hepatic steatosis 10.11 9.27 190 304573 48641 110235895
Fractured skull depressed 10.11 9.27 4 304759 40 110284496
Amyotrophy 10.11 9.27 11 304752 687 110283849
Therapeutic aspiration 10.10 9.27 3 304760 11 110284525
Mandibular mass 10.10 9.27 7 304756 236 110284300
Anaphylactic reaction 10.10 9.27 398 304365 113902 110170634
Palmoplantar pustulosis 10.07 9.27 13 304750 973 110283563
Anaemia folate deficiency 10.07 9.27 11 304752 690 110283846
Odynophagia 10.06 9.27 70 304693 14031 110270505
Polyomavirus-associated nephropathy 10.06 9.27 5 304758 8196 110276340
Neuropsychiatric lupus 10.02 9.27 7 304756 239 110284297
Eosinophilic pneumonia 10.01 9.27 43 304720 7184 110277352
Ovarian cystectomy 10.01 9.27 5 304758 90 110284446
Aortic valve incompetence 10.00 9.27 58 304705 10923 110273613
Pleural infection 9.98 9.27 10 304753 567 110283969
Blood thyroid stimulating hormone increased 9.94 9.27 63 304700 12238 110272298
Anhedonia 9.93 9.27 17 304746 15411 110269125
Uveal melanoma 9.93 9.27 4 304759 42 110284494
Stevens-Johnson syndrome 9.89 9.27 183 304580 46718 110237818
Nasal crusting 9.82 9.27 12 304751 849 110283687
Atrioventricular block first degree 9.79 9.27 15 304748 14210 110270326
Scleroderma 9.79 9.27 39 304724 6302 110278234
Cystic fibrosis 9.77 9.27 32 304731 4699 110279837
Chronic cutaneous lupus erythematosus 9.73 9.27 13 304750 1006 110283530
Bullous impetigo 9.70 9.27 3 304760 13 110284523
Brucellosis 9.70 9.27 6 304757 166 110284370
Diastolic dysfunction 9.70 9.27 63 304700 12341 110272195
Lordosis 9.69 9.27 9 304754 464 110284072
Brief psychotic disorder with marked stressors 9.69 9.27 8 304755 352 110284184
Pulmonary vasculitis 9.69 9.27 3 304760 6557 110277979
Thyroid stimulating hormone deficiency 9.69 9.27 4 304759 45 110284491
Azotaemia 9.66 9.27 54 304709 10031 110274505
Aplasia pure red cell 9.66 9.27 52 304711 9526 110275010
Diverticulum intestinal haemorrhagic 9.64 9.27 32 304731 4731 110279805
Tongue pruritus 9.64 9.27 12 304751 866 110283670
Lipase increased 9.63 9.27 86 304677 18586 110265950
Cyst 9.57 9.27 78 304685 16418 110268118
Simple partial seizures 9.56 9.27 13 304750 1023 110283513
Eye disorder 9.54 9.27 44 304719 28862 110255674
Prinzmetal angina 9.51 9.27 20 304743 2249 110282287
Immune-mediated myocarditis 9.44 9.27 26 304737 3472 110281064
Catheter site pain 9.43 9.27 39 304724 6407 110278129
Dyshidrotic eczema 9.41 9.27 11 304752 743 110283793
Injection site bruising 9.39 9.27 93 304670 51170 110233366
Biliary anastomosis complication 9.39 9.27 6 304757 176 110284360
Septic arthritis staphylococcal 9.39 9.27 12 304751 889 110283647
Hypocholesterolaemia 9.37 9.27 3 304760 6418 110278118
Dissociation 9.36 9.27 8 304755 9834 110274702
Tongue eruption 9.33 9.27 6 304757 178 110284358
Primary adrenal insufficiency 9.33 9.27 10 304753 614 110283922
Methaemoglobinaemia 9.28 9.27 7 304756 9161 110275375

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pleural effusion 31.73 31.38 8 160 31 113754

Pharmacologic Action:

SourceCodeDescription
ATC A02BC05 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Proton pump inhibitors
ATC A02BD06 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC M01AE52 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
FDA MoA N0000000147 Proton Pump Inhibitors
FDA EPC N0000175525 Proton Pump Inhibitor
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054328 Proton Pump Inhibitors
FDA MoA N0000182140 Cytochrome P450 2C19 Inhibitors
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:49200 EC 3.6.3.10 (<em>H</em><small><sup>+</small></sup>/<em>K</em><small><sup>+</small></sup>-exchanging ATPase) inhibitor
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50183 P450 inhibitor
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:64951 anti-HBV agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:233423 antifibrotic agent
CHEBI has role CHEBI:37956 histamine antagonist
CHEBI has role CHEBI:38623 EC 1.4.3.4 (monoamine oxidase) inhibitor

Related Drugs by ATC class:

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A02BD Combinations for eradication of Helicobacter pylori 13 drugs
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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Erosive esophagitis indication 40719004
Zollinger-Ellison syndrome indication 53132006 DOID:0050782
Peptic reflux disease indication 57643001
Gastroesophageal reflux disease indication 235595009 DOID:8534
Maintenance of Healing Erosive Esophagitis indication
Osteoarthritis in Patients at High Ulcer Risk indication
Duodenal Ulcer due to H. Pylori indication
Rheumatoid Arthritis in Patient at High Ulcer Risk indication
Prevention of NSAID-Induced Gastric Ulcer indication
Pathological Gastric Hypersecretory Condition indication
Upper gastrointestinal hemorrhage off-label use 37372002
Hepatic failure contraindication 59927004
Osteoporosis contraindication 64859006 DOID:11476
Atrophic gastritis contraindication 84568007 DOID:8929
Fracture of bone contraindication 125605004
Hypomagnesemia contraindication 190855004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.71 acidic
pKa2 4.44 Basic
pKa3 2.53 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium-transporting ATPase Transporter INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4021259 VUID
N0000189434 NUI
D01984 KEGG_DRUG
217087-10-0 SECONDARY_CAS_RN
161796-78-7 SECONDARY_CAS_RN
4019439 VANDF
4021259 VANDF
4021260 VANDF
4025229 VANDF
4032661 VANDF
C0937846 UMLSCUI
CHEBI:50275 CHEBI
1C6 PDB_CHEM_ID
CHEMBL1201320 ChEMBL_ID
CHEMBL5314366 ChEMBL_ID
DB00736 DRUGBANK_ID
CHEMBL1200470 ChEMBL_ID
CHEMBL2146140 ChEMBL_ID
D064098 MESH_DESCRIPTOR_UI
9568614 PUBCHEM_CID
5488 IUPHAR_LIGAND_ID
7766 INN_ID
934714-36-0 SECONDARY_CAS_RN
N3PA6559FT UNII
1294569 RXNORM
19233 MMSL
205449 MMSL
211151 MMSL
232889 MMSL
29630 MMSL
45807 MMSL
5201 MMSL
d00325 MMSL
d04749 MMSL
003476 NDDF
008590 NDDF
008918 NDDF
008919 NDDF
015173 NDDF
129489006 SNOMEDCT_US
25673006 SNOMEDCT_US
317331009 SNOMEDCT_US
387137007 SNOMEDCT_US
396047003 SNOMEDCT_US
426956003 SNOMEDCT_US
725855001 SNOMEDCT_US
C0028978 UMLSCUI
DB00338 DRUGBANK_ID
4594 PUBCHEM_CID
5081 INN_ID
D009853 MESH_DESCRIPTOR_UI
CHEBI:7772 CHEBI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
good sense esomeprazole magnesium HUMAN OTC DRUG LABEL 1 0113-0651 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
Good Sense Esomeprazole Magnesium HUMAN OTC DRUG LABEL 1 0113-0898 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
good sense esomeprazole magnesium HUMAN OTC DRUG LABEL 1 0113-2022 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
Esomeprazole Magnesium Human OTC Drug Label 1 0363-0361 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 12 sections
Esomeprazole Magnesium Human OTC Drug Label 1 0363-0508 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 12 sections
Esomeprazole Magnesium HUMAN OTC DRUG LABEL 1 0363-1699 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
esomeprazole magnesium HUMAN OTC DRUG LABEL 1 0363-7223 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
Up and Up Esomeprazole Magnesium HUMAN OTC DRUG LABEL 1 11673-753 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
up and up esomeprazole magnesium HUMAN OTC DRUG LABEL 1 11673-898 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
esomeprazole magnesium HUMAN OTC DRUG LABEL 1 11822-0024 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
esomeprazole magnesium HUMAN OTC DRUG LABEL 1 11822-0898 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
esomeprazole magnesium HUMAN OTC DRUG LABEL 1 11822-4011 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
Esomeprazole sodium HUMAN PRESCRIPTION DRUG LABEL 1 14335-060 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 40 mg INTRAVENOUS ANDA 28 sections
signature care esomeprazole magnesium HUMAN OTC DRUG LABEL 1 21130-088 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
Esomeprazole Magnesium Human OTC Drug Label 1 21130-100 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 12 sections
signature care esomeprazole magnesium HUMAN OTC DRUG LABEL 1 21130-714 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
esomeprazole magnesium HUMAN OTC DRUG LABEL 1 30142-273 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
esomeprazole Human Prescription Drug Label 1 33342-306 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
esomeprazole Human Prescription Drug Label 1 33342-307 CAPSULE, DELAYED RELEASE 40 mg ORAL ANDA 27 sections
topcare esomeprazole magnesium HUMAN OTC DRUG LABEL 1 36800-627 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
Topcare Esomeprazole Magnesium HUMAN OTC DRUG LABEL 1 36800-636 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
Esomeprazole Magnesium HUMAN OTC DRUG LABEL 1 37808-719 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
equaline esomeprazole magnesium HUMAN OTC DRUG LABEL 1 41163-539 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 14 sections
esomeprazole magnesium HUMAN OTC DRUG LABEL 1 41250-727 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
esomeprazole magnesium HUMAN OTC DRUG LABEL 1 41250-900 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
careone esomeprazole magnesium HUMAN OTC DRUG LABEL 1 41520-727 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
careone esomeprazole magnesium HUMAN OTC DRUG LABEL 1 41520-727 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
esomeprazole magnesium HUMAN OTC DRUG LABEL 1 42507-774 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
esomeprazole magnesium HUMAN OTC DRUG LABEL 1 42507-898 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
Esomeprazole Magnesium HUMAN PRESCRIPTION DRUG LABEL 1 45865-892 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 28 sections