Stem definition | Drug id | CAS RN |
---|---|---|
antiulcer, benzimidazole derivatives | 1055 | 119141-88-7 |
Dose | Unit | Route |
---|---|---|
30 | mg | O |
30 | mg | P |
0.50 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 5.79 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 53 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.20 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.85 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.03 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 0.83 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 20, 2001 | FDA | ASTRAZENECA PHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Chronic kidney disease | 877.06 | 9.29 | 948 | 219573 | 41108 | 56030438 |
Pemphigus | 553.54 | 9.29 | 13 | 220508 | 157199 | 55914347 |
Drug ineffective | 463.23 | 9.29 | 1946 | 218575 | 917043 | 55154503 |
Glossodynia | 431.45 | 9.29 | 47 | 220474 | 152411 | 55919135 |
Systemic lupus erythematosus | 405.09 | 9.29 | 103 | 220418 | 179975 | 55891571 |
Maternal exposure during pregnancy | 381.68 | 9.29 | 133 | 220388 | 189420 | 55882126 |
Hand deformity | 376.65 | 9.29 | 43 | 220478 | 134449 | 55937097 |
Synovitis | 361.36 | 9.29 | 93 | 220428 | 161212 | 55910334 |
Renal injury | 334.52 | 9.29 | 278 | 220243 | 8609 | 56062937 |
Anti-cyclic citrullinated peptide antibody positive | 329.49 | 9.29 | 13 | 220508 | 98587 | 55972959 |
Wound | 301.49 | 9.29 | 85 | 220436 | 138719 | 55932827 |
Pericarditis | 299.57 | 9.29 | 37 | 220484 | 108886 | 55962660 |
Alopecia | 295.96 | 9.29 | 432 | 220089 | 293026 | 55778520 |
Acute kidney injury | 290.19 | 9.29 | 1772 | 218749 | 238991 | 55832555 |
Contraindicated product administered | 286.10 | 9.29 | 189 | 220332 | 186097 | 55885449 |
Gastrooesophageal reflux disease | 281.42 | 9.29 | 840 | 219681 | 82417 | 55989129 |
End stage renal disease | 280.97 | 9.29 | 215 | 220306 | 5896 | 56065650 |
Rheumatoid arthritis | 263.53 | 9.29 | 705 | 219816 | 381899 | 55689647 |
Arthropathy | 247.01 | 9.29 | 252 | 220269 | 200023 | 55871523 |
Completed suicide | 241.34 | 9.29 | 111 | 220410 | 133722 | 55937824 |
Duodenal ulcer perforation | 231.80 | 9.29 | 8 | 220513 | 68334 | 56003212 |
Off label use | 222.49 | 9.29 | 1275 | 219246 | 554905 | 55516641 |
Discomfort | 200.36 | 9.29 | 157 | 220364 | 141604 | 55929942 |
Drug intolerance | 197.61 | 9.29 | 468 | 220053 | 264350 | 55807196 |
Rheumatoid factor positive | 196.01 | 9.29 | 21 | 220500 | 69039 | 56002507 |
Infusion related reaction | 192.01 | 9.29 | 327 | 220194 | 208604 | 55862942 |
Hepatocellular injury | 190.25 | 9.29 | 359 | 220162 | 26155 | 56045391 |
Helicobacter infection | 182.79 | 9.29 | 33 | 220488 | 73235 | 55998311 |
Carotid artery thrombosis | 179.29 | 9.29 | 111 | 220410 | 2133 | 56069413 |
Joint swelling | 176.76 | 9.29 | 565 | 219956 | 289235 | 55782311 |
Cholestasis | 176.73 | 9.29 | 351 | 220170 | 26562 | 56044984 |
Treatment failure | 176.35 | 9.29 | 246 | 220275 | 170146 | 55901400 |
Neurologic neglect syndrome | 176.32 | 9.29 | 109 | 220412 | 2089 | 56069457 |
Swelling | 171.56 | 9.29 | 433 | 220088 | 239338 | 55832208 |
Hepatic enzyme increased | 165.12 | 9.29 | 260 | 220261 | 171124 | 55900422 |
Interstitial lung disease | 160.92 | 9.29 | 541 | 219980 | 56522 | 56015024 |
Cholecystitis chronic | 159.56 | 9.29 | 194 | 220327 | 9554 | 56061992 |
Exposure during pregnancy | 158.62 | 9.29 | 180 | 220341 | 136162 | 55935384 |
Adjustment disorder | 158.47 | 9.29 | 104 | 220417 | 2219 | 56069327 |
Folliculitis | 155.30 | 9.29 | 17 | 220504 | 54962 | 56016584 |
Muscle injury | 154.13 | 9.29 | 14 | 220507 | 52486 | 56019060 |
Hyponatraemia | 147.19 | 9.29 | 789 | 219732 | 101350 | 55970196 |
Therapeutic product effect decreased | 143.32 | 9.29 | 279 | 220242 | 169173 | 55902373 |
Product use issue | 142.52 | 9.29 | 324 | 220197 | 185717 | 55885829 |
Personality disorder | 141.31 | 9.29 | 135 | 220386 | 5038 | 56066508 |
Renal failure | 133.89 | 9.29 | 815 | 219706 | 109685 | 55961861 |
Toxicity to various agents | 125.81 | 9.29 | 454 | 220067 | 224110 | 55847436 |
Hemiplegia | 122.77 | 9.29 | 158 | 220363 | 8246 | 56063300 |
Abdominal discomfort | 120.18 | 9.29 | 618 | 219903 | 276656 | 55794890 |
Sensitisation | 117.03 | 9.29 | 87 | 220434 | 2281 | 56069265 |
Peripheral swelling | 115.91 | 9.29 | 499 | 220022 | 234227 | 55837319 |
Biliary dyskinesia | 115.25 | 9.29 | 89 | 220432 | 2474 | 56069072 |
Fatigue | 110.91 | 9.29 | 2304 | 218217 | 786248 | 55285298 |
Dysphagia | 108.00 | 9.29 | 618 | 219903 | 81329 | 55990217 |
Death | 107.81 | 9.29 | 839 | 219682 | 340587 | 55730959 |
Tubulointerstitial nephritis | 107.79 | 9.29 | 216 | 220305 | 16449 | 56055097 |
Product use in unapproved indication | 107.20 | 9.29 | 246 | 220275 | 140576 | 55930970 |
Intentional product use issue | 102.11 | 9.29 | 145 | 220376 | 99588 | 55971958 |
Polycystic ovaries | 99.20 | 9.29 | 91 | 220430 | 3223 | 56068323 |
Hypertensive nephropathy | 92.13 | 9.29 | 44 | 220477 | 490 | 56071056 |
Ejection fraction | 91.52 | 9.29 | 66 | 220455 | 1649 | 56069897 |
Blister | 91.39 | 9.29 | 180 | 220341 | 108707 | 55962839 |
Coordination abnormal | 90.66 | 9.29 | 171 | 220350 | 12450 | 56059096 |
Psoriatic arthropathy | 90.14 | 9.29 | 94 | 220427 | 73914 | 55997632 |
Sleep disorder due to general medical condition, insomnia type | 89.57 | 9.29 | 29 | 220492 | 43309 | 56028237 |
Agranulocytosis | 88.53 | 9.29 | 241 | 220280 | 22418 | 56049128 |
Motor dysfunction | 85.87 | 9.29 | 142 | 220379 | 9315 | 56062231 |
Affect lability | 83.95 | 9.29 | 146 | 220375 | 9979 | 56061567 |
Inappropriate antidiuretic hormone secretion | 81.54 | 9.29 | 172 | 220349 | 13584 | 56057962 |
Rash maculo-papular | 81.41 | 9.29 | 274 | 220247 | 28633 | 56042913 |
Eosinophilia | 79.90 | 9.29 | 215 | 220306 | 19862 | 56051684 |
Rhinitis allergic | 77.96 | 9.29 | 128 | 220393 | 8346 | 56063200 |
Lower respiratory tract infection | 76.91 | 9.29 | 214 | 220307 | 114580 | 55956966 |
C-reactive protein abnormal | 75.42 | 9.29 | 25 | 220496 | 36784 | 56034762 |
Hypersensitivity | 75.39 | 9.29 | 642 | 219879 | 255766 | 55815780 |
Toxic skin eruption | 72.17 | 9.29 | 149 | 220372 | 11590 | 56059956 |
Pain | 71.72 | 9.29 | 2015 | 218506 | 661169 | 55410377 |
Irritable bowel syndrome | 71.59 | 9.29 | 98 | 220423 | 68360 | 56003186 |
Gastritis | 71.11 | 9.29 | 297 | 220224 | 34405 | 56037141 |
Ill-defined disorder | 69.81 | 9.29 | 100 | 220421 | 68443 | 56003103 |
Sensory loss | 69.13 | 9.29 | 125 | 220396 | 8810 | 56062736 |
Abdominal pain upper | 67.99 | 9.29 | 1028 | 219493 | 177285 | 55894261 |
Hypomagnesaemia | 66.84 | 9.29 | 233 | 220288 | 24782 | 56046764 |
Nephrectomy | 65.46 | 9.29 | 47 | 220474 | 1166 | 56070380 |
Systemic lupus erythematosus rash | 65.05 | 9.29 | 57 | 220464 | 1899 | 56069647 |
Condition aggravated | 64.07 | 9.29 | 958 | 219563 | 343940 | 55727606 |
Device expulsion | 63.59 | 9.29 | 20 | 220501 | 30429 | 56041117 |
Drug reaction with eosinophilia and systemic symptoms | 63.38 | 9.29 | 261 | 220260 | 30043 | 56041503 |
Gastric polyps | 61.26 | 9.29 | 69 | 220452 | 3129 | 56068417 |
Epigastric discomfort | 61.06 | 9.29 | 97 | 220424 | 6151 | 56065395 |
Hemiparesis | 60.78 | 9.29 | 204 | 220317 | 21286 | 56050260 |
Rash | 59.53 | 9.29 | 1474 | 219047 | 491573 | 55579973 |
Hiatus hernia | 58.66 | 9.29 | 190 | 220331 | 19462 | 56052084 |
Bronchial neoplasm | 58.50 | 9.29 | 31 | 220490 | 437 | 56071109 |
Hypocalcaemia | 56.48 | 9.29 | 243 | 220278 | 28517 | 56043029 |
Knee arthroplasty | 56.42 | 9.29 | 54 | 220467 | 44205 | 56027341 |
Hepatic cytolysis | 56.29 | 9.29 | 129 | 220392 | 10777 | 56060769 |
Sleep apnoea syndrome | 55.72 | 9.29 | 226 | 220295 | 25835 | 56045711 |
Eating disorder | 55.30 | 9.29 | 170 | 220351 | 16935 | 56054611 |
Pleural fibrosis | 55.25 | 9.29 | 68 | 220453 | 3391 | 56068155 |
Loss of employment | 53.76 | 9.29 | 51 | 220470 | 1886 | 56069660 |
Gallbladder disorder | 53.02 | 9.29 | 169 | 220352 | 17165 | 56054381 |
Presbyacusis | 52.27 | 9.29 | 60 | 220461 | 2778 | 56068768 |
Anxiety | 52.16 | 9.29 | 1054 | 219467 | 192118 | 55879428 |
Gallbladder injury | 51.71 | 9.29 | 42 | 220479 | 1258 | 56070288 |
Aphasia | 51.53 | 9.29 | 246 | 220275 | 30169 | 56041377 |
Pregnancy | 51.33 | 9.29 | 33 | 220488 | 33000 | 56038546 |
Nephropathy | 49.29 | 9.29 | 83 | 220438 | 5526 | 56066020 |
Pleural thickening | 49.20 | 9.29 | 57 | 220464 | 2666 | 56068880 |
Acute generalised exanthematous pustulosis | 49.04 | 9.29 | 115 | 220406 | 9754 | 56061792 |
Blood magnesium increased | 48.73 | 9.29 | 59 | 220462 | 2892 | 56068654 |
Rebound acid hypersecretion | 48.39 | 9.29 | 24 | 220497 | 292 | 56071254 |
Mobility decreased | 47.84 | 9.29 | 212 | 220309 | 98779 | 55972767 |
Nephrogenic anaemia | 46.98 | 9.29 | 47 | 220474 | 1857 | 56069689 |
Nasal turbinate hypertrophy | 46.41 | 9.29 | 31 | 220490 | 682 | 56070864 |
Diabetic nephropathy | 45.87 | 9.29 | 40 | 220481 | 1324 | 56070222 |
Nasopharyngitis | 45.86 | 9.29 | 600 | 219921 | 220359 | 55851187 |
Abortion spontaneous | 45.37 | 9.29 | 63 | 220458 | 43690 | 56027856 |
Impaired healing | 45.04 | 9.29 | 181 | 220340 | 86660 | 55984886 |
Hip arthroplasty | 44.87 | 9.29 | 51 | 220470 | 38572 | 56032974 |
Bronchial disorder | 44.50 | 9.29 | 37 | 220484 | 1146 | 56070400 |
Angina pectoris | 44.33 | 9.29 | 222 | 220299 | 27754 | 56043792 |
Arterial occlusive disease | 43.54 | 9.29 | 77 | 220444 | 5333 | 56066213 |
Anaemia | 43.44 | 9.29 | 1363 | 219158 | 266148 | 55805398 |
Deafness neurosensory | 43.27 | 9.29 | 71 | 220450 | 4627 | 56066919 |
Bronchial haemorrhage | 43.10 | 9.29 | 27 | 220494 | 530 | 56071016 |
Osteosclerosis | 43.09 | 9.29 | 62 | 220459 | 3601 | 56067945 |
Live birth | 42.54 | 9.29 | 12 | 220509 | 19593 | 56051953 |
Drug abuse | 42.38 | 9.29 | 130 | 220391 | 67480 | 56004066 |
Cholelithiasis | 42.14 | 9.29 | 282 | 220239 | 39182 | 56032364 |
Hypothyroidism | 42.03 | 9.29 | 275 | 220246 | 37921 | 56033625 |
Premature delivery | 40.74 | 9.29 | 28 | 220493 | 27032 | 56044514 |
Prescription form tampering | 39.93 | 9.29 | 26 | 220495 | 547 | 56070999 |
Gamma-glutamyltransferase increased | 39.63 | 9.29 | 232 | 220289 | 30773 | 56040773 |
Therapy non-responder | 39.16 | 9.29 | 117 | 220404 | 61238 | 56010308 |
Abdominal pain | 39.00 | 9.29 | 1307 | 219214 | 257498 | 55814048 |
Carpal tunnel syndrome | 38.51 | 9.29 | 157 | 220364 | 17987 | 56053559 |
Pancreatitis | 38.30 | 9.29 | 305 | 220216 | 44775 | 56026771 |
Pancreatitis acute | 38.15 | 9.29 | 197 | 220324 | 24927 | 56046619 |
Asthenia | 38.13 | 9.29 | 1675 | 218846 | 341298 | 55730248 |
Gastric disorder | 37.70 | 9.29 | 241 | 220280 | 32969 | 56038577 |
Adverse drug reaction | 37.53 | 9.29 | 130 | 220391 | 65002 | 56006544 |
Musculoskeletal stiffness | 36.78 | 9.29 | 412 | 220109 | 155595 | 55915951 |
Cholecystitis | 36.46 | 9.29 | 132 | 220389 | 14303 | 56057243 |
Axonal neuropathy | 36.20 | 9.29 | 30 | 220491 | 925 | 56070621 |
Hypokalaemia | 35.77 | 9.29 | 544 | 219977 | 93893 | 55977653 |
Stomatitis | 35.67 | 9.29 | 302 | 220219 | 120508 | 55951038 |
Fall | 35.64 | 9.29 | 1727 | 218794 | 355783 | 55715763 |
Dermatitis bullous | 35.21 | 9.29 | 86 | 220435 | 7487 | 56064059 |
COVID-19 | 34.91 | 9.29 | 163 | 220358 | 74895 | 55996651 |
Lung disorder | 34.88 | 9.29 | 337 | 220184 | 52260 | 56019286 |
Red blood cell sedimentation rate abnormal | 34.39 | 9.29 | 15 | 220506 | 18658 | 56052888 |
Dysarthria | 34.37 | 9.29 | 269 | 220252 | 39281 | 56032265 |
Cross sensitivity reaction | 34.28 | 9.29 | 41 | 220480 | 1984 | 56069562 |
Nephritic syndrome | 34.27 | 9.29 | 18 | 220503 | 249 | 56071297 |
Infection | 34.11 | 9.29 | 565 | 219956 | 199641 | 55871905 |
Foetal exposure during pregnancy | 33.79 | 9.29 | 50 | 220471 | 33773 | 56037773 |
Endometrial ablation | 33.41 | 9.29 | 28 | 220493 | 877 | 56070669 |
Tenosynovitis stenosans | 33.35 | 9.29 | 46 | 220475 | 2568 | 56068978 |
Injection site erythema | 32.69 | 9.29 | 174 | 220347 | 77274 | 55994272 |
Drug resistance | 32.64 | 9.29 | 20 | 220501 | 20522 | 56051024 |
Drug interaction | 32.53 | 9.29 | 1063 | 219458 | 208692 | 55862854 |
Renal disorder | 32.48 | 9.29 | 213 | 220308 | 29392 | 56042154 |
Impaired work ability | 32.46 | 9.29 | 128 | 220393 | 14444 | 56057102 |
Dyspepsia | 32.07 | 9.29 | 482 | 220039 | 82989 | 55988557 |
Iron deficiency anaemia | 31.86 | 9.29 | 147 | 220374 | 17772 | 56053774 |
Intentional overdose | 31.64 | 9.29 | 148 | 220373 | 67969 | 56003577 |
Phlebitis | 31.50 | 9.29 | 73 | 220448 | 6143 | 56065403 |
Vascular purpura | 30.90 | 9.29 | 32 | 220489 | 1318 | 56070228 |
Cholestatic liver injury | 30.81 | 9.29 | 41 | 220480 | 2211 | 56069335 |
Drug hypersensitivity | 30.65 | 9.29 | 832 | 219689 | 274373 | 55797173 |
Gastric antral vascular ectasia | 30.22 | 9.29 | 22 | 220499 | 558 | 56070988 |
Urate nephropathy | 29.92 | 9.29 | 13 | 220508 | 114 | 56071432 |
Bone cyst | 29.77 | 9.29 | 39 | 220482 | 2071 | 56069475 |
Rhabdomyolysis | 29.72 | 9.29 | 266 | 220255 | 40392 | 56031154 |
Caesarean section | 29.52 | 9.29 | 13 | 220508 | 16078 | 56055468 |
Dry eye | 29.44 | 9.29 | 240 | 220281 | 35476 | 56036070 |
Sleep disorder due to a general medical condition | 29.06 | 9.29 | 90 | 220431 | 9000 | 56062546 |
Hypergastrinaemia | 28.56 | 9.29 | 12 | 220509 | 96 | 56071450 |
Cell death | 28.38 | 9.29 | 40 | 220481 | 2279 | 56069267 |
Palpitations | 27.92 | 9.29 | 547 | 219974 | 99125 | 55972421 |
Anal abscess | 27.86 | 9.29 | 55 | 220466 | 4142 | 56067404 |
Nausea | 27.84 | 9.29 | 3408 | 217113 | 760770 | 55310776 |
Arthralgia | 27.70 | 9.29 | 1646 | 218875 | 500023 | 55571523 |
Malnutrition | 27.23 | 9.29 | 118 | 220403 | 13890 | 56057656 |
Nephritis allergic | 26.89 | 9.29 | 13 | 220508 | 149 | 56071397 |
Erythema dyschromicum perstans | 26.81 | 9.29 | 10 | 220511 | 56 | 56071490 |
Muscle spasticity | 26.58 | 9.29 | 151 | 220370 | 19809 | 56051737 |
Respiratory tract congestion | 26.33 | 9.29 | 126 | 220395 | 15465 | 56056081 |
Synovial fluid analysis | 26.08 | 9.29 | 35 | 220486 | 1903 | 56069643 |
Accidental exposure to product | 26.05 | 9.29 | 35 | 220486 | 24612 | 56046934 |
Muscular weakness | 25.90 | 9.29 | 563 | 219958 | 103889 | 55967657 |
Sinus congestion | 25.78 | 9.29 | 126 | 220395 | 15598 | 56055948 |
Occupational asthma | 25.74 | 9.29 | 12 | 220509 | 126 | 56071420 |
Chest pain | 25.70 | 9.29 | 947 | 219574 | 188850 | 55882696 |
Therapy interrupted | 25.48 | 9.29 | 38 | 220483 | 25587 | 56045959 |
Angina bullosa haemorrhagica | 25.25 | 9.29 | 12 | 220509 | 132 | 56071414 |
Blood test abnormal | 25.09 | 9.29 | 108 | 220413 | 12676 | 56058870 |
Ejection fraction abnormal | 25.04 | 9.29 | 26 | 220495 | 1074 | 56070472 |
Renal impairment | 25.04 | 9.29 | 450 | 220071 | 80263 | 55991283 |
Bone erosion | 24.61 | 9.29 | 14 | 220507 | 14960 | 56056586 |
Muscle contractions involuntary | 24.54 | 9.29 | 35 | 220486 | 2016 | 56069530 |
Dry mouth | 24.37 | 9.29 | 370 | 220151 | 63835 | 56007711 |
No adverse event | 24.20 | 9.29 | 68 | 220453 | 36306 | 56035240 |
Face oedema | 24.18 | 9.29 | 139 | 220382 | 18313 | 56053233 |
Crepitations | 24.07 | 9.29 | 71 | 220450 | 6913 | 56064633 |
Eosinophilic fasciitis | 23.77 | 9.29 | 12 | 220509 | 152 | 56071394 |
Gangrene | 23.75 | 9.29 | 61 | 220460 | 5479 | 56066067 |
Cutaneous lupus erythematosus | 23.73 | 9.29 | 39 | 220482 | 2545 | 56069001 |
Gallbladder polyp | 23.56 | 9.29 | 21 | 220500 | 716 | 56070830 |
Muscle haemorrhage | 23.50 | 9.29 | 42 | 220479 | 2933 | 56068613 |
Kidney infection | 23.28 | 9.29 | 150 | 220371 | 20575 | 56050971 |
Macular degeneration | 23.03 | 9.29 | 24 | 220497 | 18884 | 56052662 |
Rheumatoid nodule | 22.91 | 9.29 | 117 | 220404 | 14740 | 56056806 |
Oesophagitis | 22.59 | 9.29 | 112 | 220409 | 13945 | 56057601 |
Lip oedema | 22.39 | 9.29 | 45 | 220476 | 3433 | 56068113 |
Cyst | 22.11 | 9.29 | 104 | 220417 | 12674 | 56058872 |
Asthma | 21.95 | 9.29 | 588 | 219933 | 112182 | 55959364 |
Mesenteric panniculitis | 21.79 | 9.29 | 10 | 220511 | 101 | 56071445 |
Hypocapnia | 21.73 | 9.29 | 15 | 220506 | 349 | 56071197 |
Electric shock | 21.62 | 9.29 | 24 | 220497 | 1071 | 56070475 |
Scleritis | 21.53 | 9.29 | 46 | 220475 | 3665 | 56067881 |
Pancreatic neuroendocrine tumour | 21.47 | 9.29 | 16 | 220505 | 421 | 56071125 |
Injection site pain | 21.44 | 9.29 | 326 | 220195 | 116792 | 55954754 |
Cerebral haematoma | 21.40 | 9.29 | 43 | 220478 | 3280 | 56068266 |
Schizophreniform disorder | 21.32 | 9.29 | 9 | 220512 | 73 | 56071473 |
General physical health deterioration | 21.31 | 9.29 | 505 | 220016 | 169505 | 55902041 |
Neutropenic sepsis | 21.20 | 9.29 | 17 | 220504 | 15168 | 56056378 |
Poisoning | 21.03 | 9.29 | 12 | 220509 | 12801 | 56058745 |
Gastrointestinal haemorrhage | 20.99 | 9.29 | 416 | 220105 | 75535 | 55996011 |
Febrile bone marrow aplasia | 20.95 | 9.29 | 65 | 220456 | 6507 | 56065039 |
Gallbladder hypofunction | 20.88 | 9.29 | 17 | 220504 | 511 | 56071035 |
Herpes simplex test positive | 20.70 | 9.29 | 11 | 220510 | 156 | 56071390 |
Haematoma | 20.66 | 9.29 | 204 | 220317 | 31815 | 56039731 |
Neurotoxicity | 20.45 | 9.29 | 19 | 220502 | 15776 | 56055770 |
Dehydration | 20.42 | 9.29 | 788 | 219733 | 158037 | 55913509 |
Adverse event | 20.38 | 9.29 | 130 | 220391 | 55246 | 56016300 |
Flatulence | 20.02 | 9.29 | 199 | 220322 | 31089 | 56040457 |
Oesophageal dilatation | 19.97 | 9.29 | 14 | 220507 | 334 | 56071212 |
Nephrosclerosis | 19.95 | 9.29 | 22 | 220499 | 974 | 56070572 |
Cholecystectomy | 19.92 | 9.29 | 83 | 220438 | 9601 | 56061945 |
Subacute cutaneous lupus erythematosus | 19.64 | 9.29 | 34 | 220487 | 2315 | 56069231 |
Blood alkaline phosphatase increased | 19.53 | 9.29 | 236 | 220285 | 38709 | 56032837 |
Contusion | 19.45 | 9.29 | 370 | 220151 | 128060 | 55943486 |
Hepatic steatosis | 19.41 | 9.29 | 172 | 220349 | 26042 | 56045504 |
Burning sensation | 19.40 | 9.29 | 283 | 220238 | 48413 | 56023133 |
Supraventricular extrasystoles | 19.38 | 9.29 | 47 | 220474 | 4073 | 56067473 |
Type 2 diabetes mellitus | 19.38 | 9.29 | 106 | 220415 | 46756 | 56024790 |
Gastrointestinal motility disorder | 19.33 | 9.29 | 51 | 220470 | 4655 | 56066891 |
Haemoglobin decreased | 19.30 | 9.29 | 674 | 219847 | 133463 | 55938083 |
Myelosuppression | 19.26 | 9.29 | 24 | 220497 | 17431 | 56054115 |
Medication error | 19.06 | 9.29 | 93 | 220428 | 42242 | 56029304 |
Tetany | 18.97 | 9.29 | 28 | 220493 | 1664 | 56069882 |
Haematotoxicity | 18.43 | 9.29 | 5 | 220516 | 8378 | 56063168 |
Liver function test increased | 18.42 | 9.29 | 53 | 220468 | 28080 | 56043466 |
Small cell carcinoma | 18.38 | 9.29 | 10 | 220511 | 149 | 56071397 |
International normalised ratio increased | 18.36 | 9.29 | 258 | 220263 | 43783 | 56027763 |
Therapeutic response decreased | 18.34 | 9.29 | 126 | 220395 | 52632 | 56018914 |
Rectosigmoid cancer | 18.32 | 9.29 | 10 | 220511 | 150 | 56071396 |
Hepatitis cholestatic | 18.23 | 9.29 | 61 | 220460 | 6353 | 56065193 |
Hepatotoxicity | 18.06 | 9.29 | 62 | 220459 | 31091 | 56040455 |
Acute hepatitis B | 17.95 | 9.29 | 13 | 220508 | 327 | 56071219 |
Pneumobilia | 17.83 | 9.29 | 9 | 220512 | 114 | 56071432 |
Bradypnoea | 17.78 | 9.29 | 39 | 220482 | 3164 | 56068382 |
Congenital osteodystrophy | 17.52 | 9.29 | 6 | 220515 | 25 | 56071521 |
Anaemia macrocytic | 17.47 | 9.29 | 38 | 220483 | 3065 | 56068481 |
Bile duct stone | 17.36 | 9.29 | 40 | 220481 | 3354 | 56068192 |
Normal newborn | 17.31 | 9.29 | 4 | 220517 | 7466 | 56064080 |
Gastric ulcer | 17.21 | 9.29 | 149 | 220372 | 22414 | 56049132 |
Nerve injury | 17.15 | 9.29 | 75 | 220446 | 8862 | 56062684 |
Hyperchlorhydria | 17.07 | 9.29 | 26 | 220495 | 1589 | 56069957 |
Drug eruption | 17.04 | 9.29 | 165 | 220356 | 25598 | 56045948 |
Device dependence | 16.96 | 9.29 | 5 | 220516 | 11 | 56071535 |
Livedo reticularis | 16.95 | 9.29 | 31 | 220490 | 2204 | 56069342 |
Ulcer | 16.89 | 9.29 | 148 | 220373 | 22337 | 56049209 |
Erosive oesophagitis | 16.77 | 9.29 | 26 | 220495 | 1614 | 56069932 |
Muscle swelling | 16.75 | 9.29 | 14 | 220507 | 437 | 56071109 |
Osteopenia | 16.66 | 9.29 | 125 | 220396 | 18016 | 56053530 |
Sedation | 16.61 | 9.29 | 75 | 220446 | 34779 | 56036767 |
Bunion operation | 16.58 | 9.29 | 22 | 220499 | 1183 | 56070363 |
Eczema | 16.57 | 9.29 | 166 | 220355 | 25987 | 56045559 |
Injection site bruising | 16.56 | 9.29 | 86 | 220435 | 38435 | 56033111 |
Emotional distress | 16.55 | 9.29 | 184 | 220337 | 29579 | 56041967 |
IIIrd nerve paresis | 16.49 | 9.29 | 9 | 220512 | 135 | 56071411 |
Anaemia folate deficiency | 16.48 | 9.29 | 10 | 220511 | 185 | 56071361 |
Mixed liver injury | 16.47 | 9.29 | 43 | 220478 | 3901 | 56067645 |
Pathological fracture | 16.39 | 9.29 | 69 | 220452 | 8020 | 56063526 |
Genital infection female | 16.37 | 9.29 | 8 | 220513 | 94 | 56071452 |
Arterial spasm | 16.35 | 9.29 | 7 | 220514 | 59 | 56071487 |
Hunger | 16.34 | 9.29 | 48 | 220473 | 4663 | 56066883 |
Diverticulum | 16.27 | 9.29 | 86 | 220435 | 10980 | 56060566 |
Injection site swelling | 16.19 | 9.29 | 102 | 220419 | 43476 | 56028070 |
Skin lesion | 16.14 | 9.29 | 175 | 220346 | 27960 | 56043586 |
Vertigo | 16.13 | 9.29 | 302 | 220219 | 54270 | 56017276 |
Cerebrovascular accident | 16.12 | 9.29 | 506 | 220015 | 98764 | 55972782 |
Angina unstable | 16.08 | 9.29 | 61 | 220460 | 6760 | 56064786 |
Oesophageal polyp | 15.96 | 9.29 | 4 | 220517 | 3 | 56071543 |
Tooth infection | 15.88 | 9.29 | 111 | 220410 | 15641 | 56055905 |
Non-economic loss | 15.86 | 9.29 | 5 | 220516 | 15 | 56071531 |
Escherichia pyelonephritis | 15.79 | 9.29 | 13 | 220508 | 397 | 56071149 |
Jaundice | 15.76 | 9.29 | 170 | 220351 | 27124 | 56044422 |
Cardiac disorder | 15.73 | 9.29 | 260 | 220261 | 45627 | 56025919 |
Injection site pruritus | 15.66 | 9.29 | 98 | 220423 | 41833 | 56029713 |
Nasal discharge discolouration | 15.58 | 9.29 | 27 | 220494 | 1840 | 56069706 |
Renal cyst | 15.55 | 9.29 | 75 | 220446 | 9234 | 56062312 |
Photophobia | 15.54 | 9.29 | 112 | 220409 | 15938 | 56055608 |
Blood chromogranin A increased | 15.49 | 9.29 | 11 | 220510 | 268 | 56071278 |
Angioedema | 15.38 | 9.29 | 238 | 220283 | 41215 | 56030331 |
Transient ischaemic attack | 15.35 | 9.29 | 200 | 220321 | 33377 | 56038169 |
Rhonchi | 15.35 | 9.29 | 31 | 220490 | 2373 | 56069173 |
Prescribed overdose | 15.34 | 9.29 | 41 | 220480 | 22255 | 56049291 |
Blood potassium increased | 15.33 | 9.29 | 118 | 220403 | 17143 | 56054403 |
Deformity | 15.28 | 9.29 | 80 | 220441 | 10175 | 56061371 |
Prothrombin time ratio decreased | 15.28 | 9.29 | 13 | 220508 | 416 | 56071130 |
Chondrocalcinosis pyrophosphate | 15.17 | 9.29 | 21 | 220500 | 1176 | 56070370 |
Pancreatitis chronic | 15.15 | 9.29 | 30 | 220491 | 2264 | 56069282 |
Oesophagitis ulcerative | 15.14 | 9.29 | 14 | 220507 | 501 | 56071045 |
Proteinuria | 14.99 | 9.29 | 119 | 220402 | 17451 | 56054095 |
Early satiety | 14.99 | 9.29 | 18 | 220503 | 875 | 56070671 |
Adenocarcinoma gastric | 14.93 | 9.29 | 14 | 220507 | 510 | 56071036 |
Thrombocytopenia | 14.80 | 9.29 | 664 | 219857 | 135560 | 55935986 |
Weight increased | 14.79 | 9.29 | 742 | 219779 | 228961 | 55842585 |
Therapy partial responder | 14.74 | 9.29 | 6 | 220515 | 7779 | 56063767 |
Keratoacanthoma | 14.69 | 9.29 | 13 | 220508 | 439 | 56071107 |
Dialysis | 14.68 | 9.29 | 76 | 220445 | 9626 | 56061920 |
Cerebellar haematoma | 14.67 | 9.29 | 12 | 220509 | 363 | 56071183 |
Product dose omission issue | 14.65 | 9.29 | 654 | 219867 | 204099 | 55867447 |
Premature labour | 14.56 | 9.29 | 15 | 220506 | 11867 | 56059679 |
Synovial cyst | 14.51 | 9.29 | 73 | 220448 | 9141 | 56062405 |
Meningitis aseptic | 14.48 | 9.29 | 44 | 220477 | 4355 | 56067191 |
Renal tubular disorder | 14.46 | 9.29 | 31 | 220490 | 2475 | 56069071 |
Disease progression | 14.42 | 9.29 | 308 | 220213 | 104865 | 55966681 |
Eyelid oedema | 14.42 | 9.29 | 76 | 220445 | 9692 | 56061854 |
Hyperparathyroidism secondary | 14.30 | 9.29 | 22 | 220499 | 1357 | 56070189 |
Sudden death | 14.29 | 9.29 | 75 | 220446 | 9550 | 56061996 |
Drug tolerance decreased | 14.22 | 9.29 | 19 | 220502 | 13392 | 56058154 |
Neutropenia | 14.19 | 9.29 | 492 | 220029 | 157675 | 55913871 |
Pleuritic pain | 14.14 | 9.29 | 60 | 220461 | 6997 | 56064549 |
Hepatitis | 14.13 | 9.29 | 206 | 220315 | 35235 | 56036311 |
Hyperthermia | 14.02 | 9.29 | 67 | 220454 | 8218 | 56063328 |
Melaena | 14.00 | 9.29 | 171 | 220350 | 28119 | 56043427 |
Ingrowing nail | 13.92 | 9.29 | 28 | 220493 | 2137 | 56069409 |
Body temperature increased | 13.86 | 9.29 | 78 | 220443 | 34164 | 56037382 |
Pre-eclampsia | 13.85 | 9.29 | 8 | 220513 | 8478 | 56063068 |
Dermatitis exfoliative | 13.85 | 9.29 | 49 | 220472 | 5250 | 56066296 |
Protein-losing gastroenteropathy | 13.84 | 9.29 | 9 | 220512 | 189 | 56071357 |
Uveal melanoma | 13.82 | 9.29 | 4 | 220517 | 8 | 56071538 |
Calcium metabolism disorder | 13.78 | 9.29 | 8 | 220513 | 136 | 56071410 |
Chronic cutaneous lupus erythematosus | 13.76 | 9.29 | 10 | 220511 | 253 | 56071293 |
Oedema peripheral | 13.75 | 9.29 | 811 | 219710 | 170443 | 55901103 |
Purging | 13.67 | 9.29 | 6 | 220515 | 54 | 56071492 |
Haemorrhoids | 13.66 | 9.29 | 130 | 220391 | 20076 | 56051470 |
Gastrinoma | 13.64 | 9.29 | 3 | 220518 | 0 | 56071546 |
Erythema | 13.59 | 9.29 | 744 | 219777 | 155195 | 55916351 |
Type I hypersensitivity | 13.56 | 9.29 | 30 | 220491 | 2448 | 56069098 |
Gastrointestinal tract mucosal pigmentation | 13.47 | 9.29 | 14 | 220507 | 579 | 56070967 |
Multi-organ disorder | 13.45 | 9.29 | 21 | 220500 | 1312 | 56070234 |
Renal hypertrophy | 13.41 | 9.29 | 5 | 220516 | 28 | 56071518 |
Faeces discoloured | 13.36 | 9.29 | 113 | 220408 | 16883 | 56054663 |
Teeth brittle | 13.35 | 9.29 | 13 | 220508 | 497 | 56071049 |
Vitamin B12 decreased | 13.33 | 9.29 | 34 | 220487 | 3041 | 56068505 |
Illness | 13.23 | 9.29 | 80 | 220441 | 34431 | 56037115 |
Hypoplastic anaemia | 13.21 | 9.29 | 4 | 220517 | 10 | 56071536 |
Abortion induced | 13.21 | 9.29 | 11 | 220510 | 9634 | 56061912 |
Creatinine renal clearance decreased | 13.15 | 9.29 | 23 | 220498 | 14536 | 56057010 |
Hyponatraemic seizure | 13.13 | 9.29 | 12 | 220509 | 423 | 56071123 |
Musculoskeletal chest pain | 13.09 | 9.29 | 126 | 220395 | 19515 | 56052031 |
Liver injury | 13.08 | 9.29 | 103 | 220418 | 41745 | 56029801 |
Lordosis | 13.07 | 9.29 | 10 | 220511 | 274 | 56071272 |
Brucellosis | 13.04 | 9.29 | 6 | 220515 | 61 | 56071485 |
Renal haemangioma | 12.98 | 9.29 | 5 | 220516 | 31 | 56071515 |
Atelectasis | 12.94 | 9.29 | 124 | 220397 | 19184 | 56052362 |
Intestinal infarction | 12.94 | 9.29 | 18 | 220503 | 1013 | 56070533 |
Campylobacter colitis | 12.85 | 9.29 | 5 | 220516 | 32 | 56071514 |
Female sterilisation | 12.82 | 9.29 | 13 | 220508 | 522 | 56071024 |
Chest discomfort | 12.82 | 9.29 | 491 | 220030 | 98366 | 55973180 |
Antinuclear antibody positive | 12.82 | 9.29 | 57 | 220464 | 6784 | 56064762 |
Bladder sphincter atony | 12.77 | 9.29 | 8 | 220513 | 157 | 56071389 |
Renal atrophy | 12.76 | 9.29 | 21 | 220500 | 1372 | 56070174 |
Thymus disorder | 12.74 | 9.29 | 10 | 220511 | 285 | 56071261 |
Sinus bradycardia | 12.70 | 9.29 | 94 | 220427 | 13492 | 56058054 |
Lipase increased | 12.67 | 9.29 | 69 | 220452 | 8910 | 56062636 |
Congenital bowing of long bones | 12.63 | 9.29 | 6 | 220515 | 66 | 56071480 |
Hyperlipasaemia | 12.62 | 9.29 | 13 | 220508 | 532 | 56071014 |
Rash scarlatiniform | 12.60 | 9.29 | 7 | 220514 | 109 | 56071437 |
Clinically isolated syndrome | 12.59 | 9.29 | 5 | 220516 | 34 | 56071512 |
Musculoskeletal disorder | 12.58 | 9.29 | 36 | 220485 | 19111 | 56052435 |
Eructation | 12.58 | 9.29 | 61 | 220460 | 7527 | 56064019 |
Renal tubular necrosis | 12.55 | 9.29 | 79 | 220442 | 10749 | 56060797 |
Hyperkalaemia | 12.55 | 9.29 | 274 | 220247 | 50591 | 56020955 |
Sneezing | 12.52 | 9.29 | 104 | 220417 | 15456 | 56056090 |
Bursitis | 12.49 | 9.29 | 164 | 220357 | 27418 | 56044128 |
Monoclonal gammopathy | 12.48 | 9.29 | 14 | 220507 | 632 | 56070914 |
Immunodeficiency | 12.46 | 9.29 | 28 | 220493 | 16129 | 56055417 |
Disability | 12.46 | 9.29 | 27 | 220494 | 15753 | 56055793 |
Hyperphosphatasaemia | 12.45 | 9.29 | 4 | 220517 | 13 | 56071533 |
Rectal haemorrhage | 12.44 | 9.29 | 230 | 220291 | 41237 | 56030309 |
Malabsorption | 12.37 | 9.29 | 38 | 220483 | 3783 | 56067763 |
Sinus disorder | 12.37 | 9.29 | 130 | 220391 | 20604 | 56050942 |
Paranasal sinus inflammation | 12.34 | 9.29 | 12 | 220509 | 458 | 56071088 |
Infusion site scar | 12.32 | 9.29 | 11 | 220510 | 376 | 56071170 |
Tongue oedema | 12.28 | 9.29 | 39 | 220482 | 3953 | 56067593 |
Purpura | 12.26 | 9.29 | 76 | 220445 | 10286 | 56061260 |
Gastrointestinal ischaemia | 12.14 | 9.29 | 8 | 220513 | 172 | 56071374 |
Obesity | 12.14 | 9.29 | 46 | 220475 | 22402 | 56049144 |
Intervertebral discitis | 12.13 | 9.29 | 31 | 220490 | 2776 | 56068770 |
Aspartate aminotransferase increased | 12.11 | 9.29 | 416 | 220105 | 82186 | 55989360 |
Regurgitation | 12.10 | 9.29 | 21 | 220500 | 1433 | 56070113 |
Complication of device insertion | 12.09 | 9.29 | 5 | 220516 | 6419 | 56065127 |
Hypoosmolar state | 12.02 | 9.29 | 8 | 220513 | 175 | 56071371 |
Coronary artery occlusion | 12.01 | 9.29 | 61 | 220460 | 7668 | 56063878 |
Neurosis | 11.94 | 9.29 | 9 | 220512 | 241 | 56071305 |
Diarrhoea | 11.92 | 9.29 | 2748 | 217773 | 635759 | 55435787 |
Essential hypertension | 11.92 | 9.29 | 43 | 220478 | 4650 | 56066896 |
Poor personal hygiene | 11.86 | 9.29 | 10 | 220511 | 316 | 56071230 |
Drug ineffective for unapproved indication | 11.82 | 9.29 | 56 | 220465 | 25637 | 56045909 |
Device dislocation | 11.79 | 9.29 | 47 | 220474 | 22559 | 56048987 |
Maternal exposure before pregnancy | 11.77 | 9.29 | 6 | 220515 | 6817 | 56064729 |
Allergy to chemicals | 11.71 | 9.29 | 28 | 220493 | 2405 | 56069141 |
Dilatation atrial | 11.69 | 9.29 | 24 | 220497 | 1859 | 56069687 |
Wrong technique in product usage process | 11.66 | 9.29 | 159 | 220362 | 58009 | 56013537 |
Crystal arthropathy | 11.66 | 9.29 | 9 | 220512 | 250 | 56071296 |
Aeromonas infection | 11.62 | 9.29 | 6 | 220515 | 80 | 56071466 |
Hypofibrinogenaemia | 11.59 | 9.29 | 18 | 220503 | 1119 | 56070427 |
Hypoparathyroidism secondary | 11.59 | 9.29 | 5 | 220516 | 43 | 56071503 |
Vitreous detachment | 11.59 | 9.29 | 24 | 220497 | 1871 | 56069675 |
Platelet adhesiveness decreased | 11.57 | 9.29 | 3 | 220518 | 3 | 56071543 |
Gastric adenoma | 11.57 | 9.29 | 3 | 220518 | 3 | 56071543 |
Colitis ischaemic | 11.55 | 9.29 | 73 | 220448 | 9947 | 56061599 |
Colitis | 11.55 | 9.29 | 229 | 220292 | 41582 | 56029964 |
Atrioventricular block complete | 11.54 | 9.29 | 59 | 220462 | 7435 | 56064111 |
Loss of personal independence in daily activities | 11.53 | 9.29 | 237 | 220284 | 81132 | 55990414 |
Rhinalgia | 11.50 | 9.29 | 18 | 220503 | 1127 | 56070419 |
Breast cancer stage I | 11.48 | 9.29 | 5 | 220516 | 6225 | 56065321 |
Unintentional medical device removal | 11.43 | 9.29 | 4 | 220517 | 5690 | 56065856 |
Muscle enzyme increased | 11.42 | 9.29 | 7 | 220514 | 132 | 56071414 |
Polyglandular autoimmune syndrome type II | 11.40 | 9.29 | 5 | 220516 | 45 | 56071501 |
Hypertensive crisis | 11.39 | 9.29 | 94 | 220427 | 13942 | 56057604 |
Enterocolitis haemorrhagic | 11.35 | 9.29 | 20 | 220501 | 1381 | 56070165 |
Dysphonia | 11.33 | 9.29 | 229 | 220292 | 41718 | 56029828 |
Therapeutic response shortened | 11.33 | 9.29 | 12 | 220509 | 9374 | 56062172 |
Gastric ulcer haemorrhage | 11.29 | 9.29 | 42 | 220479 | 4611 | 56066935 |
Retinal artery occlusion | 11.25 | 9.29 | 21 | 220500 | 1517 | 56070029 |
Stent placement | 11.21 | 9.29 | 35 | 220486 | 3516 | 56068030 |
Septic shock | 11.21 | 9.29 | 315 | 220206 | 60520 | 56011026 |
Vulvovaginal burning sensation | 11.19 | 9.29 | 22 | 220499 | 1652 | 56069894 |
Hepatic function abnormal | 11.18 | 9.29 | 194 | 220327 | 34364 | 56037182 |
Tachycardia paroxysmal | 11.15 | 9.29 | 9 | 220512 | 267 | 56071279 |
Purpura senile | 11.15 | 9.29 | 12 | 220509 | 517 | 56071029 |
Vulval disorder | 11.10 | 9.29 | 14 | 220507 | 716 | 56070830 |
Rectal cancer metastatic | 11.07 | 9.29 | 9 | 220512 | 270 | 56071276 |
Blood thyroid stimulating hormone increased | 11.05 | 9.29 | 53 | 220468 | 6510 | 56065036 |
Finger deformity | 11.02 | 9.29 | 6 | 220515 | 6571 | 56064975 |
Anaemia vitamin B12 deficiency | 11.02 | 9.29 | 10 | 220511 | 349 | 56071197 |
Blood magnesium decreased | 11.01 | 9.29 | 82 | 220439 | 11792 | 56059754 |
Nikolsky's sign | 10.94 | 9.29 | 6 | 220515 | 91 | 56071455 |
Dysgeusia | 10.93 | 9.29 | 223 | 220298 | 40692 | 56030854 |
Dermatosis | 10.93 | 9.29 | 9 | 220512 | 275 | 56071271 |
Purple glove syndrome | 10.92 | 9.29 | 8 | 220513 | 205 | 56071341 |
Hypoparathyroidism | 10.90 | 9.29 | 13 | 220508 | 627 | 56070919 |
Diverticulum oesophageal | 10.89 | 9.29 | 7 | 220514 | 144 | 56071402 |
Iron deficiency | 10.88 | 9.29 | 51 | 220470 | 6205 | 56065341 |
Dystonia | 10.88 | 9.29 | 20 | 220501 | 12401 | 56059145 |
Dysuria | 10.86 | 9.29 | 175 | 220346 | 30554 | 56040992 |
Acute sinusitis | 10.84 | 9.29 | 35 | 220486 | 3578 | 56067968 |
Thrombocytopenic purpura | 10.84 | 9.29 | 19 | 220502 | 1307 | 56070239 |
Seizure | 10.80 | 9.29 | 391 | 220130 | 124728 | 55946818 |
Lumbar spinal stenosis | 10.79 | 9.29 | 40 | 220481 | 4383 | 56067163 |
Blood gastrin increased | 10.78 | 9.29 | 4 | 220517 | 22 | 56071524 |
Throat irritation | 10.77 | 9.29 | 184 | 220337 | 32499 | 56039047 |
Bicytopenia | 10.75 | 9.29 | 25 | 220496 | 2108 | 56069438 |
Heat stroke | 10.74 | 9.29 | 14 | 220507 | 740 | 56070806 |
Affective disorder | 10.74 | 9.29 | 47 | 220474 | 5556 | 56065990 |
Concussion | 10.73 | 9.29 | 62 | 220459 | 8184 | 56063362 |
Renal hypertension | 10.72 | 9.29 | 7 | 220514 | 148 | 56071398 |
Gastric haemorrhage | 10.72 | 9.29 | 49 | 220472 | 5901 | 56065645 |
Gastrointestinal disorder | 10.71 | 9.29 | 348 | 220173 | 112354 | 55959192 |
Laboratory test abnormal | 10.69 | 9.29 | 55 | 220466 | 24640 | 56046906 |
Acute cutaneous lupus erythematosus | 10.66 | 9.29 | 9 | 220512 | 285 | 56071261 |
Cholangitis | 10.64 | 9.29 | 43 | 220478 | 4906 | 56066640 |
Vulvovaginal inflammation | 10.61 | 9.29 | 14 | 220507 | 749 | 56070797 |
Transplant rejection | 10.60 | 9.29 | 14 | 220507 | 9920 | 56061626 |
Oesophageal ulcer | 10.58 | 9.29 | 38 | 220483 | 4101 | 56067445 |
Gastric cancer | 10.55 | 9.29 | 37 | 220484 | 3946 | 56067600 |
Acute coronary syndrome | 10.54 | 9.29 | 70 | 220451 | 9698 | 56061848 |
Dislocation of vertebra | 10.54 | 9.29 | 4 | 220517 | 5411 | 56066135 |
Carnitine deficiency | 10.52 | 9.29 | 7 | 220514 | 153 | 56071393 |
Placental calcification | 10.50 | 9.29 | 4 | 220517 | 24 | 56071522 |
Oedema mouth | 10.49 | 9.29 | 26 | 220495 | 2284 | 56069262 |
Dyslipidaemia | 10.48 | 9.29 | 51 | 220470 | 6302 | 56065244 |
Cholecystitis acute | 10.47 | 9.29 | 57 | 220464 | 7359 | 56064187 |
Pyelonephritis acute | 10.44 | 9.29 | 39 | 220482 | 4290 | 56067256 |
Antipsychotic drug level above therapeutic | 10.42 | 9.29 | 16 | 220505 | 985 | 56070561 |
Acute myeloid leukaemia | 10.37 | 9.29 | 33 | 220488 | 16939 | 56054607 |
Bronchopneumopathy | 10.37 | 9.29 | 8 | 220513 | 222 | 56071324 |
Hepatobiliary scan abnormal | 10.37 | 9.29 | 5 | 220516 | 57 | 56071489 |
Cardiothoracic ratio increased | 10.36 | 9.29 | 4 | 220517 | 25 | 56071521 |
Resorption bone increased | 10.33 | 9.29 | 18 | 220503 | 1232 | 56070314 |
Vomiting | 10.33 | 9.29 | 2155 | 218366 | 496073 | 55575473 |
Pulmonary embolism | 10.32 | 9.29 | 516 | 220005 | 106608 | 55964938 |
Abdominal adhesions | 10.31 | 9.29 | 30 | 220491 | 2899 | 56068647 |
Peripheral artery thrombosis | 10.28 | 9.29 | 22 | 220499 | 1755 | 56069791 |
Renal infarct | 10.27 | 9.29 | 19 | 220502 | 1363 | 56070183 |
Tongue pruritus | 10.24 | 9.29 | 11 | 220510 | 473 | 56071073 |
Eye haematoma | 10.23 | 9.29 | 4 | 220517 | 26 | 56071520 |
Pulmonary artery stenosis | 10.21 | 9.29 | 7 | 220514 | 161 | 56071385 |
Crohn's disease | 10.18 | 9.29 | 51 | 220470 | 6376 | 56065170 |
Deep vein thrombosis | 10.14 | 9.29 | 383 | 220138 | 76594 | 55994952 |
Skin haemorrhage | 10.14 | 9.29 | 62 | 220459 | 8351 | 56063195 |
Tonic clonic movements | 10.12 | 9.29 | 18 | 220503 | 1252 | 56070294 |
Portal vein dilatation | 10.10 | 9.29 | 4 | 220517 | 27 | 56071519 |
Language disorder | 10.06 | 9.29 | 23 | 220498 | 1918 | 56069628 |
Respiratory depression | 10.05 | 9.29 | 21 | 220500 | 12414 | 56059132 |
Fracture nonunion | 10.04 | 9.29 | 25 | 220496 | 2202 | 56069344 |
Erythema multiforme | 10.03 | 9.29 | 68 | 220453 | 9486 | 56062060 |
Breast cancer stage II | 10.02 | 9.29 | 5 | 220516 | 5753 | 56065793 |
Tri-iodothyronine free decreased | 10.02 | 9.29 | 9 | 220512 | 310 | 56071236 |
Cough | 10.00 | 9.29 | 1164 | 219357 | 258797 | 55812749 |
Fungal oesophagitis | 9.95 | 9.29 | 12 | 220509 | 586 | 56070960 |
Blood loss anaemia | 9.91 | 9.29 | 61 | 220460 | 8236 | 56063310 |
Urinary incontinence | 9.91 | 9.29 | 167 | 220354 | 29418 | 56042128 |
Hypoxic-ischaemic encephalopathy | 9.90 | 9.29 | 36 | 220485 | 3909 | 56067637 |
Atypical fracture | 9.85 | 9.29 | 12 | 220509 | 592 | 56070954 |
Vagus nerve disorder | 9.84 | 9.29 | 6 | 220515 | 112 | 56071434 |
Small intestinal stenosis | 9.83 | 9.29 | 11 | 220510 | 495 | 56071051 |
Unintended pregnancy | 9.83 | 9.29 | 4 | 220517 | 5187 | 56066359 |
Hypertriglyceridaemia | 9.82 | 9.29 | 47 | 220474 | 5769 | 56065777 |
Spinal osteoarthritis | 9.80 | 9.29 | 95 | 220426 | 14741 | 56056805 |
Renal lymphocele | 9.79 | 9.29 | 5 | 220516 | 65 | 56071481 |
Arterial fibrosis | 9.77 | 9.29 | 3 | 220518 | 8 | 56071538 |
Coma acidotic | 9.75 | 9.29 | 6 | 220515 | 114 | 56071432 |
Renal tuberculosis | 9.74 | 9.29 | 4 | 220517 | 30 | 56071516 |
Oesophageal irritation | 9.70 | 9.29 | 6 | 220515 | 115 | 56071431 |
Mandibular mass | 9.70 | 9.29 | 7 | 220514 | 175 | 56071371 |
Subdural haematoma | 9.70 | 9.29 | 88 | 220433 | 13411 | 56058135 |
Blood creatine phosphokinase decreased | 9.69 | 9.29 | 10 | 220511 | 410 | 56071136 |
Rhinitis | 9.69 | 9.29 | 64 | 220457 | 8852 | 56062694 |
Liver abscess | 9.67 | 9.29 | 28 | 220493 | 2698 | 56068848 |
Grip strength decreased | 9.66 | 9.29 | 32 | 220489 | 16224 | 56055322 |
Lichen planus | 9.61 | 9.29 | 24 | 220497 | 2118 | 56069428 |
Neuroleptic malignant syndrome | 9.60 | 9.29 | 19 | 220502 | 11459 | 56060087 |
Microcytic anaemia | 9.59 | 9.29 | 31 | 220490 | 3171 | 56068375 |
Low turnover osteopathy | 9.57 | 9.29 | 36 | 220485 | 3972 | 56067574 |
Actinic keratosis | 9.56 | 9.29 | 25 | 220496 | 2270 | 56069276 |
Blood cholesterol increased | 9.53 | 9.29 | 214 | 220307 | 72365 | 55999181 |
Therapy cessation | 9.53 | 9.29 | 65 | 220456 | 27199 | 56044347 |
Haemorrhagic cyst | 9.50 | 9.29 | 7 | 220514 | 181 | 56071365 |
Diverticulum intestinal | 9.43 | 9.29 | 50 | 220471 | 6390 | 56065156 |
Body height decreased | 9.42 | 9.29 | 65 | 220456 | 9120 | 56062426 |
Renal tubular atrophy | 9.39 | 9.29 | 13 | 220508 | 728 | 56070818 |
Biliary colic | 9.36 | 9.29 | 32 | 220489 | 3370 | 56068176 |
Tenosynovitis | 9.35 | 9.29 | 82 | 220439 | 12379 | 56059167 |
Vertigo positional | 9.32 | 9.29 | 27 | 220494 | 2602 | 56068944 |
Vitamin B12 deficiency | 9.31 | 9.29 | 38 | 220483 | 4355 | 56067191 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Chronic kidney disease | 552.21 | 10.03 | 728 | 129143 | 37247 | 31530226 |
Toxicity to various agents | 218.76 | 10.03 | 253 | 129618 | 181234 | 31386239 |
End stage renal disease | 201.38 | 10.03 | 205 | 129666 | 7904 | 31559569 |
Death | 194.66 | 10.03 | 790 | 129081 | 359779 | 31207694 |
Drug abuse | 190.69 | 10.03 | 61 | 129810 | 87697 | 31479776 |
Acute kidney injury | 187.77 | 10.03 | 1858 | 128013 | 277856 | 31289617 |
Drug ineffective | 178.85 | 10.03 | 925 | 128946 | 394648 | 31172825 |
Completed suicide | 161.18 | 10.03 | 87 | 129784 | 91427 | 31476046 |
Cholestasis | 152.21 | 10.03 | 325 | 129546 | 24750 | 31542723 |
Gastrooesophageal reflux disease | 142.79 | 10.03 | 381 | 129490 | 33490 | 31533983 |
Off label use | 142.55 | 10.03 | 838 | 129033 | 346436 | 31221037 |
Hepatocellular injury | 139.82 | 10.03 | 287 | 129584 | 21257 | 31546216 |
Toxic skin eruption | 130.88 | 10.03 | 184 | 129687 | 9996 | 31557477 |
Renal injury | 130.10 | 10.03 | 188 | 129683 | 10477 | 31556996 |
Interstitial lung disease | 129.76 | 10.03 | 547 | 129324 | 60856 | 31506617 |
Hypomagnesaemia | 95.56 | 10.03 | 229 | 129642 | 18829 | 31548644 |
Eosinophilia | 92.41 | 10.03 | 256 | 129615 | 22997 | 31544476 |
Agranulocytosis | 80.59 | 10.03 | 230 | 129641 | 21017 | 31546456 |
Hypocalcaemia | 76.74 | 10.03 | 231 | 129640 | 21747 | 31545726 |
Hepatic cytolysis | 75.97 | 10.03 | 149 | 129722 | 10674 | 31556799 |
Treatment failure | 75.93 | 10.03 | 36 | 129835 | 40756 | 31526717 |
Renal failure | 68.64 | 10.03 | 790 | 129081 | 122540 | 31444933 |
Product use in unapproved indication | 66.15 | 10.03 | 198 | 129673 | 98973 | 31468500 |
Nephrogenic anaemia | 65.07 | 10.03 | 60 | 129811 | 2043 | 31565430 |
Tubulointerstitial nephritis | 64.20 | 10.03 | 194 | 129677 | 18302 | 31549171 |
Foetal exposure during pregnancy | 59.55 | 10.03 | 48 | 129823 | 40828 | 31526645 |
Occult blood | 55.02 | 10.03 | 34 | 129837 | 621 | 31566852 |
COVID-19 | 54.23 | 10.03 | 88 | 129783 | 54733 | 31512740 |
Hypertensive nephropathy | 49.39 | 10.03 | 28 | 129843 | 433 | 31567040 |
Hepatojugular reflux | 49.22 | 10.03 | 30 | 129841 | 534 | 31566939 |
Drug reaction with eosinophilia and systemic symptoms | 48.98 | 10.03 | 248 | 129623 | 29770 | 31537703 |
Pancreatitis acute | 48.64 | 10.03 | 221 | 129650 | 25379 | 31542094 |
Hyperkalaemia | 47.08 | 10.03 | 436 | 129435 | 63915 | 31503558 |
Gamma-glutamyltransferase increased | 45.48 | 10.03 | 230 | 129641 | 27595 | 31539878 |
Drug resistance | 44.72 | 10.03 | 20 | 129851 | 23433 | 31544040 |
Hypergastrinaemia | 43.83 | 10.03 | 15 | 129856 | 59 | 31567414 |
Jaundice | 41.79 | 10.03 | 239 | 129632 | 30048 | 31537425 |
Ventricular hypokinesia | 41.05 | 10.03 | 72 | 129799 | 4734 | 31562739 |
Electrocardiogram Q wave abnormal | 39.56 | 10.03 | 23 | 129848 | 374 | 31567099 |
Degenerative mitral valve disease | 39.49 | 10.03 | 19 | 129852 | 205 | 31567268 |
Nephropathy | 39.14 | 10.03 | 76 | 129795 | 5403 | 31562070 |
Rash maculo-papular | 37.51 | 10.03 | 206 | 129665 | 25513 | 31541960 |
Nicotine dependence | 37.11 | 10.03 | 24 | 129847 | 476 | 31566997 |
Lung disorder | 37.01 | 10.03 | 243 | 129628 | 32069 | 31535404 |
Colitis microscopic | 36.31 | 10.03 | 43 | 129828 | 1967 | 31565506 |
Hepatitis cholestatic | 35.96 | 10.03 | 86 | 129785 | 7060 | 31560413 |
Thrombocytopenia | 35.63 | 10.03 | 800 | 129071 | 141947 | 31425526 |
Systolic dysfunction | 35.02 | 10.03 | 46 | 129825 | 2340 | 31565133 |
Pulmonary vascular disorder | 34.64 | 10.03 | 25 | 129846 | 597 | 31566876 |
Product dose omission issue | 34.03 | 10.03 | 273 | 129598 | 105313 | 31462160 |
Cholestatic liver injury | 33.98 | 10.03 | 41 | 129830 | 1913 | 31565560 |
Gastric polyps | 33.73 | 10.03 | 31 | 129840 | 1051 | 31566422 |
Cell death | 33.26 | 10.03 | 42 | 129829 | 2054 | 31565419 |
Intentional product use issue | 33.25 | 10.03 | 98 | 129773 | 49249 | 31518224 |
Vascular purpura | 32.94 | 10.03 | 35 | 129836 | 1419 | 31566054 |
Hiatus hernia | 32.19 | 10.03 | 81 | 129790 | 6866 | 31560607 |
Chronic kidney disease-mineral and bone disorder | 31.95 | 10.03 | 20 | 129851 | 374 | 31567099 |
Drug intolerance | 31.79 | 10.03 | 108 | 129763 | 51925 | 31515548 |
Diabetic nephropathy | 31.28 | 10.03 | 40 | 129831 | 1981 | 31565492 |
Hyponatraemia | 30.97 | 10.03 | 449 | 129422 | 73350 | 31494123 |
Hypokalaemia | 30.56 | 10.03 | 345 | 129526 | 53229 | 31514244 |
Eye injury | 28.34 | 10.03 | 23 | 129848 | 657 | 31566816 |
Mixed liver injury | 28.21 | 10.03 | 41 | 129830 | 2296 | 31565177 |
Intentional overdose | 28.03 | 10.03 | 82 | 129789 | 41307 | 31526166 |
Hemiplegia | 27.69 | 10.03 | 75 | 129796 | 6647 | 31560826 |
Therapy non-responder | 27.52 | 10.03 | 61 | 129810 | 33750 | 31533723 |
Drug hypersensitivity | 26.10 | 10.03 | 182 | 129689 | 72417 | 31495056 |
Drug ineffective for unapproved indication | 25.77 | 10.03 | 21 | 129850 | 17769 | 31549704 |
Physical deconditioning | 25.68 | 10.03 | 25 | 129846 | 912 | 31566561 |
Eosinophilic colitis | 25.30 | 10.03 | 14 | 129857 | 206 | 31567267 |
Therapeutic product effect incomplete | 25.15 | 10.03 | 93 | 129778 | 43603 | 31523870 |
Disease progression | 25.12 | 10.03 | 243 | 129628 | 90221 | 31477252 |
Face oedema | 24.31 | 10.03 | 97 | 129774 | 10519 | 31556954 |
Occupational dermatitis | 24.27 | 10.03 | 10 | 129861 | 72 | 31567401 |
Anaemia macrocytic | 24.19 | 10.03 | 43 | 129828 | 2857 | 31564616 |
Eczema | 24.19 | 10.03 | 126 | 129745 | 15291 | 31552182 |
Inferior vena cava dilatation | 24.07 | 10.03 | 21 | 129850 | 664 | 31566809 |
Rhabdomyolysis | 24.03 | 10.03 | 380 | 129491 | 63201 | 31504272 |
Ocular myasthenia | 24.00 | 10.03 | 14 | 129857 | 229 | 31567244 |
Granulomatous rosacea | 23.54 | 10.03 | 12 | 129859 | 148 | 31567325 |
Tubulointerstitial nephritis and uveitis syndrome | 23.37 | 10.03 | 10 | 129861 | 80 | 31567393 |
Cholangitis | 23.36 | 10.03 | 79 | 129792 | 7907 | 31559566 |
Gastroenteritis eosinophilic | 23.33 | 10.03 | 12 | 129859 | 151 | 31567322 |
Pain | 23.24 | 10.03 | 585 | 129286 | 186174 | 31381299 |
Hypophosphataemic osteomalacia | 22.84 | 10.03 | 11 | 129860 | 119 | 31567354 |
Idiopathic pulmonary fibrosis | 22.19 | 10.03 | 51 | 129820 | 4079 | 31563394 |
Chest pain | 21.93 | 10.03 | 631 | 129240 | 116326 | 31451147 |
Overlap syndrome | 21.89 | 10.03 | 10 | 129861 | 95 | 31567378 |
Brain scan abnormal | 21.86 | 10.03 | 22 | 129849 | 836 | 31566637 |
Device dependence | 21.84 | 10.03 | 8 | 129863 | 40 | 31567433 |
Renal cyst | 21.82 | 10.03 | 80 | 129791 | 8336 | 31559137 |
Cardiac failure | 21.50 | 10.03 | 482 | 129389 | 85471 | 31482002 |
Hyperchlorhydria | 21.25 | 10.03 | 19 | 129852 | 621 | 31566852 |
Dermatitis bullous | 21.19 | 10.03 | 65 | 129806 | 6180 | 31561293 |
Peripheral swelling | 21.15 | 10.03 | 177 | 129694 | 67688 | 31499785 |
Dyspepsia | 21.06 | 10.03 | 215 | 129656 | 32338 | 31535135 |
Ureteric compression | 21.01 | 10.03 | 13 | 129858 | 238 | 31567235 |
Contraindicated product administered | 20.24 | 10.03 | 31 | 129840 | 19741 | 31547732 |
Hyperthermia | 20.23 | 10.03 | 88 | 129783 | 9916 | 31557557 |
Radiation pneumonitis | 20.08 | 10.03 | 36 | 129835 | 2408 | 31565065 |
Acute pulmonary oedema | 19.83 | 10.03 | 69 | 129802 | 7007 | 31560466 |
Gastric cancer | 19.66 | 10.03 | 62 | 129809 | 5983 | 31561490 |
Helicobacter test positive | 19.64 | 10.03 | 20 | 129851 | 771 | 31566702 |
Adverse drug reaction | 19.28 | 10.03 | 47 | 129824 | 25154 | 31542319 |
Plasma cell myeloma | 19.21 | 10.03 | 144 | 129727 | 56387 | 31511086 |
Injection site pain | 19.10 | 10.03 | 75 | 129796 | 34559 | 31532914 |
Low birth weight baby | 18.80 | 10.03 | 3 | 129868 | 6967 | 31560506 |
Acute generalised exanthematous pustulosis | 18.78 | 10.03 | 61 | 129810 | 5979 | 31561494 |
Therapy interrupted | 18.74 | 10.03 | 10 | 129861 | 10586 | 31556887 |
Cross sensitivity reaction | 18.64 | 10.03 | 25 | 129846 | 1298 | 31566175 |
Occupational exposure to air contaminants | 18.57 | 10.03 | 10 | 129861 | 139 | 31567334 |
Cardiac aneurysm | 18.38 | 10.03 | 20 | 129851 | 833 | 31566640 |
Fixed eruption | 18.28 | 10.03 | 26 | 129845 | 1427 | 31566046 |
Mitral valve incompetence | 18.23 | 10.03 | 109 | 129762 | 13924 | 31553549 |
Phaeochromocytoma malignant | 17.89 | 10.03 | 8 | 129863 | 72 | 31567401 |
Premature baby | 17.85 | 10.03 | 29 | 129842 | 18037 | 31549436 |
Hepatic haematoma | 17.83 | 10.03 | 14 | 129857 | 381 | 31567092 |
Hyperkaliuria | 17.73 | 10.03 | 9 | 129862 | 110 | 31567363 |
Multiple sclerosis relapse | 17.72 | 10.03 | 14 | 129857 | 12033 | 31555440 |
Acute coronary syndrome | 17.69 | 10.03 | 101 | 129770 | 12688 | 31554785 |
Circumoral oedema | 17.66 | 10.03 | 7 | 129864 | 45 | 31567428 |
Cardiac arrest | 17.51 | 10.03 | 258 | 129613 | 88804 | 31478669 |
Febrile bone marrow aplasia | 17.41 | 10.03 | 71 | 129800 | 7775 | 31559698 |
Craniotabes | 17.40 | 10.03 | 5 | 129866 | 9 | 31567464 |
Hypoparathyroidism | 17.34 | 10.03 | 16 | 129855 | 545 | 31566928 |
Hospitalisation | 17.34 | 10.03 | 126 | 129745 | 49681 | 31517792 |
Duodenal polyp | 17.33 | 10.03 | 11 | 129860 | 211 | 31567262 |
Respiratory distress | 17.32 | 10.03 | 212 | 129659 | 33341 | 31534132 |
Haematotoxicity | 17.29 | 10.03 | 4 | 129867 | 7133 | 31560340 |
Pathogen resistance | 17.26 | 10.03 | 7 | 129864 | 8694 | 31558779 |
Helicobacter gastritis | 17.25 | 10.03 | 23 | 129848 | 1187 | 31566286 |
Carotid arteriosclerosis | 17.23 | 10.03 | 28 | 129843 | 1729 | 31565744 |
Inappropriate antidiuretic hormone secretion | 17.13 | 10.03 | 92 | 129779 | 11295 | 31556178 |
Essential hypertension | 17.04 | 10.03 | 35 | 129836 | 2592 | 31564881 |
Type III immune complex mediated reaction | 16.68 | 10.03 | 12 | 129859 | 285 | 31567188 |
Myelosuppression | 16.65 | 10.03 | 22 | 129849 | 14898 | 31552575 |
Anaemia | 16.59 | 10.03 | 1050 | 128821 | 212472 | 31355001 |
Anticoagulation drug level increased | 16.51 | 10.03 | 15 | 129856 | 501 | 31566972 |
Oesophagitis ulcerative | 16.45 | 10.03 | 17 | 129854 | 667 | 31566806 |
Weight increased | 16.40 | 10.03 | 240 | 129631 | 82707 | 31484766 |
Xerosis | 16.38 | 10.03 | 15 | 129856 | 506 | 31566967 |
Nerve degeneration | 16.36 | 10.03 | 10 | 129861 | 179 | 31567294 |
Joint swelling | 16.36 | 10.03 | 140 | 129731 | 53291 | 31514182 |
Abdominal pain upper | 16.34 | 10.03 | 360 | 129511 | 63642 | 31503831 |
Vitamin B12 deficiency | 16.27 | 10.03 | 41 | 129830 | 3478 | 31563995 |
Aggression | 16.25 | 10.03 | 88 | 129783 | 37203 | 31530270 |
Dermatitis exfoliative | 16.23 | 10.03 | 61 | 129810 | 6431 | 31561042 |
Hypovitaminosis | 16.21 | 10.03 | 15 | 129856 | 513 | 31566960 |
Ischaemic stroke | 16.13 | 10.03 | 122 | 129749 | 16849 | 31550624 |
Duodenitis | 16.12 | 10.03 | 46 | 129825 | 4202 | 31563271 |
Sudden death | 16.11 | 10.03 | 108 | 129763 | 14349 | 31553124 |
Neurotoxicity | 16.08 | 10.03 | 26 | 129845 | 16200 | 31551273 |
Hepatitis | 15.86 | 10.03 | 149 | 129722 | 21917 | 31545556 |
Cardiac failure congestive | 15.59 | 10.03 | 230 | 129641 | 79157 | 31488316 |
Respiratory depression | 15.59 | 10.03 | 22 | 129849 | 14488 | 31552985 |
Carotid artery stenosis | 15.40 | 10.03 | 48 | 129823 | 4604 | 31562869 |
Poisoning | 15.38 | 10.03 | 12 | 129859 | 10379 | 31557094 |
Eosinophilic oesophagitis | 15.37 | 10.03 | 11 | 129860 | 259 | 31567214 |
Brief psychotic disorder with marked stressors | 15.30 | 10.03 | 10 | 129861 | 202 | 31567271 |
Loss of personal independence in daily activities | 15.13 | 10.03 | 62 | 129809 | 28226 | 31539247 |
Nipple swelling | 15.06 | 10.03 | 8 | 129863 | 108 | 31567365 |
Neuroleptic malignant syndrome | 14.94 | 10.03 | 29 | 129842 | 16840 | 31550633 |
Hyperkinetic heart syndrome | 14.93 | 10.03 | 8 | 129863 | 110 | 31567363 |
Cerebral artery thrombosis | 14.92 | 10.03 | 17 | 129854 | 746 | 31566727 |
Lethargy | 14.82 | 10.03 | 95 | 129776 | 38546 | 31528927 |
Immune-mediated hepatic disorder | 14.78 | 10.03 | 15 | 129856 | 576 | 31566897 |
Intentional product misuse | 14.71 | 10.03 | 93 | 129778 | 37858 | 31529615 |
Jaundice cholestatic | 14.68 | 10.03 | 46 | 129825 | 4424 | 31563049 |
Hypotension | 14.66 | 10.03 | 687 | 129184 | 203931 | 31363542 |
Eructation | 14.65 | 10.03 | 44 | 129827 | 4135 | 31563338 |
Venoocclusive liver disease | 14.64 | 10.03 | 6 | 129865 | 7406 | 31560067 |
Gastritis | 14.58 | 10.03 | 137 | 129734 | 20155 | 31547318 |
Hepatic encephalopathy | 14.56 | 10.03 | 101 | 129770 | 13570 | 31553903 |
Tachycardia | 14.55 | 10.03 | 222 | 129649 | 75985 | 31491488 |
Renal haemangioma | 14.54 | 10.03 | 5 | 129866 | 20 | 31567453 |
Sensitisation | 14.53 | 10.03 | 9 | 129862 | 165 | 31567308 |
Antiphospholipid antibodies positive | 14.34 | 10.03 | 11 | 129860 | 289 | 31567184 |
Haematoma muscle | 14.31 | 10.03 | 21 | 129850 | 1186 | 31566287 |
High frequency ablation | 14.30 | 10.03 | 9 | 129862 | 170 | 31567303 |
Coronary artery stenosis | 14.26 | 10.03 | 73 | 129798 | 8797 | 31558676 |
Prurigo | 14.18 | 10.03 | 15 | 129856 | 605 | 31566868 |
Fatigue | 14.15 | 10.03 | 1182 | 128689 | 334024 | 31233449 |
Peripheral venous disease | 14.12 | 10.03 | 31 | 129840 | 2405 | 31565068 |
Immune reconstitution inflammatory syndrome | 14.05 | 10.03 | 8 | 129863 | 8170 | 31559303 |
Psoriasis | 14.04 | 10.03 | 123 | 129748 | 46596 | 31520877 |
Ventricular arrhythmia | 13.97 | 10.03 | 48 | 129823 | 4843 | 31562630 |
No adverse event | 13.93 | 10.03 | 38 | 129833 | 19587 | 31547886 |
Ventricular enlargement | 13.89 | 10.03 | 13 | 129858 | 451 | 31567022 |
Blood alkaline phosphatase increased | 13.89 | 10.03 | 183 | 129688 | 29270 | 31538203 |
Accidental exposure to product | 13.83 | 10.03 | 16 | 129855 | 11479 | 31555994 |
Fracture delayed union | 13.81 | 10.03 | 6 | 129865 | 50 | 31567423 |
Psychotic disorder | 13.79 | 10.03 | 46 | 129825 | 22247 | 31545226 |
Echocardiogram abnormal | 13.76 | 10.03 | 18 | 129853 | 912 | 31566561 |
Mucormycosis | 13.74 | 10.03 | 3 | 129868 | 5567 | 31561906 |
Essential tremor | 13.74 | 10.03 | 16 | 129855 | 719 | 31566754 |
Pancreatitis | 13.59 | 10.03 | 214 | 129657 | 35557 | 31531916 |
Benign abdominal neoplasm | 13.55 | 10.03 | 7 | 129864 | 89 | 31567384 |
Oesophageal adenocarcinoma | 13.52 | 10.03 | 17 | 129854 | 828 | 31566645 |
Muscle haemorrhage | 13.51 | 10.03 | 38 | 129833 | 3442 | 31564031 |
Bronchial injury | 13.51 | 10.03 | 3 | 129868 | 0 | 31567473 |
Acquired cystic kidney disease | 13.51 | 10.03 | 3 | 129868 | 0 | 31567473 |
Stevens-Johnson syndrome | 13.35 | 10.03 | 119 | 129752 | 17253 | 31550220 |
Oesophageal dilatation | 13.35 | 10.03 | 8 | 129863 | 138 | 31567335 |
Cancer pain | 13.30 | 10.03 | 31 | 129840 | 2502 | 31564971 |
Antibody test abnormal | 13.15 | 10.03 | 9 | 129862 | 197 | 31567276 |
Thrombocytopenic purpura | 13.07 | 10.03 | 19 | 129852 | 1064 | 31566409 |
Neutropenic sepsis | 13.07 | 10.03 | 19 | 129852 | 12360 | 31555113 |
Prostatitis Escherichia coli | 13.04 | 10.03 | 5 | 129866 | 29 | 31567444 |
Cataract | 12.98 | 10.03 | 152 | 129719 | 23655 | 31543818 |
Chest expansion decreased | 12.90 | 10.03 | 8 | 129863 | 147 | 31567326 |
Poisoning deliberate | 12.88 | 10.03 | 7 | 129864 | 7337 | 31560136 |
Rebound acid hypersecretion | 12.83 | 10.03 | 7 | 129864 | 100 | 31567373 |
Synovitis | 12.82 | 10.03 | 19 | 129852 | 12264 | 31555209 |
Sepsis | 12.77 | 10.03 | 501 | 129370 | 151428 | 31416045 |
Myoglobinaemia | 12.71 | 10.03 | 7 | 129864 | 102 | 31567371 |
Urticaria papular | 12.70 | 10.03 | 6 | 129865 | 62 | 31567411 |
Excessive cerumen production | 12.61 | 10.03 | 10 | 129861 | 276 | 31567197 |
Oesophageal candidiasis | 12.52 | 10.03 | 41 | 129830 | 4036 | 31563437 |
Bladder cancer | 12.45 | 10.03 | 26 | 129845 | 14699 | 31552774 |
Renal atrophy | 12.39 | 10.03 | 19 | 129852 | 1116 | 31566357 |
Drug dependence | 12.38 | 10.03 | 49 | 129822 | 22530 | 31544943 |
Renal tubular disorder | 12.35 | 10.03 | 43 | 129828 | 4367 | 31563106 |
Psoriatic arthropathy | 12.32 | 10.03 | 41 | 129830 | 19842 | 31547631 |
Physical examination abnormal | 12.22 | 10.03 | 10 | 129861 | 289 | 31567184 |
Dyspnoea at rest | 12.21 | 10.03 | 37 | 129834 | 3494 | 31563979 |
Hyperparathyroidism secondary | 12.19 | 10.03 | 22 | 129849 | 1479 | 31565994 |
Aortic valve incompetence | 12.18 | 10.03 | 50 | 129821 | 5491 | 31561982 |
Suicide attempt | 12.12 | 10.03 | 96 | 129775 | 37152 | 31530321 |
Progressive multifocal leukoencephalopathy | 12.00 | 10.03 | 12 | 129859 | 9201 | 31558272 |
Renal mass | 11.99 | 10.03 | 23 | 129848 | 1620 | 31565853 |
Cholecystitis | 11.96 | 10.03 | 75 | 129796 | 9742 | 31557731 |
Prostate cancer | 11.74 | 10.03 | 98 | 129773 | 37503 | 31529970 |
Malnutrition | 11.71 | 10.03 | 84 | 129787 | 11409 | 31556064 |
Oedema peripheral | 11.64 | 10.03 | 556 | 129315 | 109283 | 31458190 |
Pulmonary valve disease | 11.57 | 10.03 | 10 | 129861 | 312 | 31567161 |
Oral pustule | 11.55 | 10.03 | 9 | 129862 | 242 | 31567231 |
Febrile neutropenia | 11.54 | 10.03 | 396 | 129475 | 121453 | 31446020 |
Hepatotoxicity | 11.47 | 10.03 | 40 | 129831 | 19086 | 31548387 |
Cutaneous vasculitis | 11.45 | 10.03 | 37 | 129834 | 3617 | 31563856 |
Exposure during pregnancy | 11.43 | 10.03 | 11 | 129860 | 8587 | 31558886 |
Respiratory arrest | 11.42 | 10.03 | 62 | 129809 | 26195 | 31541278 |
Intestinal obstruction | 11.42 | 10.03 | 132 | 129739 | 20478 | 31546995 |
Microcytic anaemia | 11.40 | 10.03 | 26 | 129845 | 2069 | 31565404 |
Crohn's disease | 11.39 | 10.03 | 40 | 129831 | 4081 | 31563392 |
Erythema of eyelid | 11.17 | 10.03 | 15 | 129856 | 780 | 31566693 |
Sacroiliitis | 11.15 | 10.03 | 20 | 129851 | 1338 | 31566135 |
Rash | 11.15 | 10.03 | 694 | 129177 | 200792 | 31366681 |
Dialysis | 11.10 | 10.03 | 78 | 129793 | 10525 | 31556948 |
Septic arthritis staphylococcal | 11.09 | 10.03 | 12 | 129859 | 497 | 31566976 |
Food interaction | 11.08 | 10.03 | 16 | 129855 | 891 | 31566582 |
Cardiorenal syndrome | 11.06 | 10.03 | 14 | 129857 | 686 | 31566787 |
Lumbar radiculopathy | 11.03 | 10.03 | 15 | 129856 | 789 | 31566684 |
Thrombotic cerebral infarction | 11.00 | 10.03 | 10 | 129861 | 334 | 31567139 |
Carbohydrate antigen 19-9 increased | 10.94 | 10.03 | 8 | 129863 | 195 | 31567278 |
Bronchomalacia | 10.92 | 10.03 | 6 | 129865 | 87 | 31567386 |
Heat stroke | 10.91 | 10.03 | 16 | 129855 | 903 | 31566570 |
Laboratory test abnormal | 10.85 | 10.03 | 40 | 129831 | 18774 | 31548699 |
Enterochromaffin cell hyperplasia | 10.76 | 10.03 | 4 | 129867 | 21 | 31567452 |
Wheezing | 10.70 | 10.03 | 95 | 129776 | 35891 | 31531582 |
Unresponsive to stimuli | 10.64 | 10.03 | 62 | 129809 | 25738 | 31541735 |
Musculoskeletal stiffness | 10.63 | 10.03 | 113 | 129758 | 41212 | 31526261 |
Pericarditis | 10.63 | 10.03 | 70 | 129801 | 9246 | 31558227 |
Anal erosion | 10.61 | 10.03 | 4 | 129867 | 22 | 31567451 |
Hypotrichosis | 10.61 | 10.03 | 4 | 129867 | 22 | 31567451 |
Drug interaction | 10.60 | 10.03 | 992 | 128879 | 207551 | 31359922 |
Oesophagitis | 10.56 | 10.03 | 87 | 129784 | 12329 | 31555144 |
Abnormal behaviour | 10.51 | 10.03 | 56 | 129815 | 23772 | 31543701 |
Nephropathy toxic | 10.51 | 10.03 | 19 | 129852 | 11334 | 31556139 |
Coombs negative haemolytic anaemia | 10.44 | 10.03 | 7 | 129864 | 148 | 31567325 |
Bicytopenia | 10.36 | 10.03 | 25 | 129846 | 2064 | 31565409 |
Injection site reaction | 10.34 | 10.03 | 20 | 129851 | 11631 | 31555842 |
Epstein-Barr virus infection | 10.33 | 10.03 | 8 | 129863 | 6945 | 31560528 |
Hypoalbuminaemia | 10.33 | 10.03 | 79 | 129792 | 10949 | 31556524 |
Barrett's oesophagus | 10.31 | 10.03 | 11 | 129860 | 448 | 31567025 |
Septic shock | 10.29 | 10.03 | 349 | 129522 | 65809 | 31501664 |
Rheumatoid arthritis | 10.28 | 10.03 | 136 | 129735 | 47673 | 31519800 |
Microcytosis | 10.27 | 10.03 | 7 | 129864 | 152 | 31567321 |
C-reactive protein abnormal | 10.25 | 10.03 | 10 | 129861 | 7759 | 31559714 |
Platelet toxicity | 10.23 | 10.03 | 3 | 129868 | 6 | 31567467 |
Infective exacerbation of chronic obstructive airways disease | 10.20 | 10.03 | 22 | 129849 | 1686 | 31565787 |
Conjunctival ulcer | 10.15 | 10.03 | 5 | 129866 | 57 | 31567416 |
Nasal crusting | 10.13 | 10.03 | 10 | 129861 | 371 | 31567102 |
Diverticulum | 10.13 | 10.03 | 53 | 129818 | 6441 | 31561032 |
Haemorrhage intracranial | 10.13 | 10.03 | 30 | 129841 | 15058 | 31552415 |
Biliary anastomosis complication | 10.09 | 10.03 | 6 | 129865 | 102 | 31567371 |
Tongue oedema | 10.06 | 10.03 | 29 | 129842 | 2664 | 31564809 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Chronic kidney disease | 611.38 | 9.18 | 972 | 284446 | 60085 | 70582941 |
Completed suicide | 421.77 | 9.18 | 193 | 285225 | 226942 | 70416084 |
Drug ineffective | 408.14 | 9.18 | 2175 | 283243 | 937577 | 69705449 |
Toxicity to various agents | 323.48 | 9.18 | 657 | 284761 | 381515 | 70261511 |
Gastrooesophageal reflux disease | 318.70 | 9.18 | 945 | 284473 | 89894 | 70553132 |
Hepatocellular injury | 316.45 | 9.18 | 622 | 284796 | 45469 | 70597557 |
Cholestasis | 301.20 | 9.18 | 623 | 284795 | 47249 | 70595777 |
Acute kidney injury | 296.04 | 9.18 | 3063 | 282355 | 471561 | 70171465 |
Interstitial lung disease | 293.32 | 9.18 | 1008 | 284410 | 103677 | 70539349 |
Synovitis | 270.73 | 9.18 | 91 | 285327 | 129137 | 70513889 |
Off label use | 268.44 | 9.18 | 1821 | 283597 | 741239 | 69901787 |
Pemphigus | 266.68 | 9.18 | 17 | 285401 | 83019 | 70560007 |
Death | 236.00 | 9.18 | 1153 | 284265 | 508908 | 70134118 |
Anti-cyclic citrullinated peptide antibody positive | 229.53 | 9.18 | 13 | 285405 | 70172 | 70572854 |
End stage renal disease | 228.14 | 9.18 | 252 | 285166 | 10881 | 70632145 |
Drug abuse | 223.41 | 9.18 | 160 | 285258 | 147096 | 70495930 |
Hand deformity | 215.26 | 9.18 | 43 | 285375 | 86439 | 70556587 |
Maternal exposure during pregnancy | 200.37 | 9.18 | 107 | 285311 | 115238 | 70527788 |
Glossodynia | 195.43 | 9.18 | 53 | 285365 | 86434 | 70556592 |
Systemic lupus erythematosus | 180.74 | 9.18 | 92 | 285326 | 101810 | 70541216 |
Toxic skin eruption | 178.79 | 9.18 | 304 | 285114 | 19858 | 70623168 |
Carotid artery thrombosis | 173.35 | 9.18 | 115 | 285303 | 2431 | 70640595 |
Duodenal ulcer perforation | 171.77 | 9.18 | 8 | 285410 | 51104 | 70591922 |
Eosinophilia | 166.38 | 9.18 | 445 | 284973 | 39874 | 70603152 |
Neurologic neglect syndrome | 165.64 | 9.18 | 109 | 285309 | 2272 | 70640754 |
Wound | 159.50 | 9.18 | 100 | 285318 | 98632 | 70544394 |
Alopecia | 153.78 | 9.18 | 358 | 285060 | 198132 | 70444894 |
Agranulocytosis | 153.58 | 9.18 | 432 | 284986 | 39866 | 70603160 |
Hypomagnesaemia | 150.49 | 9.18 | 432 | 284986 | 40332 | 70602694 |
Hyponatraemia | 147.39 | 9.18 | 1126 | 284292 | 158961 | 70484065 |
Product use in unapproved indication | 144.61 | 9.18 | 395 | 285023 | 207083 | 70435943 |
Arthropathy | 142.63 | 9.18 | 240 | 285178 | 149817 | 70493209 |
Pericarditis | 142.14 | 9.18 | 82 | 285336 | 84623 | 70558403 |
Hemiplegia | 141.45 | 9.18 | 223 | 285195 | 13672 | 70629354 |
Cholecystitis chronic | 140.58 | 9.18 | 181 | 285237 | 9195 | 70633831 |
Contraindicated product administered | 137.69 | 9.18 | 205 | 285213 | 134407 | 70508619 |
Hypocalcaemia | 135.34 | 9.18 | 443 | 284975 | 44416 | 70598610 |
Treatment failure | 134.74 | 9.18 | 233 | 285185 | 143909 | 70499117 |
Rheumatoid factor positive | 129.30 | 9.18 | 20 | 285398 | 48380 | 70594646 |
Drug intolerance | 128.92 | 9.18 | 470 | 284948 | 225217 | 70417809 |
Adjustment disorder | 127.75 | 9.18 | 104 | 285314 | 3040 | 70639986 |
Joint swelling | 125.30 | 9.18 | 558 | 284860 | 252653 | 70390373 |
Rheumatoid arthritis | 124.29 | 9.18 | 678 | 284740 | 291127 | 70351899 |
Renal failure | 124.00 | 9.18 | 1234 | 284184 | 187836 | 70455190 |
Personality disorder | 123.15 | 9.18 | 131 | 285287 | 5417 | 70637609 |
Sensitisation | 118.15 | 9.18 | 90 | 285328 | 2383 | 70640643 |
Tubulointerstitial nephritis | 114.87 | 9.18 | 343 | 285075 | 32733 | 70610293 |
Renal injury | 112.62 | 9.18 | 219 | 285199 | 15875 | 70627151 |
Helicobacter infection | 111.72 | 9.18 | 42 | 285376 | 55614 | 70587412 |
Rash maculo-papular | 111.64 | 9.18 | 451 | 284967 | 50094 | 70592932 |
Discomfort | 110.33 | 9.18 | 158 | 285260 | 105278 | 70537748 |
Infusion related reaction | 109.12 | 9.18 | 417 | 285001 | 197117 | 70445909 |
Intentional product use issue | 107.07 | 9.18 | 200 | 285218 | 119942 | 70523084 |
Biliary dyskinesia | 105.24 | 9.18 | 83 | 285335 | 2316 | 70640710 |
Folliculitis | 102.16 | 9.18 | 23 | 285395 | 42547 | 70600479 |
Muscle injury | 98.19 | 9.18 | 18 | 285400 | 38476 | 70604550 |
Polycystic ovaries | 98.17 | 9.18 | 86 | 285332 | 2786 | 70640240 |
Drug reaction with eosinophilia and systemic symptoms | 97.40 | 9.18 | 477 | 284941 | 57536 | 70585490 |
Peripheral swelling | 96.70 | 9.18 | 557 | 284861 | 236006 | 70407020 |
Exposure during pregnancy | 93.21 | 9.18 | 130 | 285288 | 87587 | 70555439 |
Swelling | 92.32 | 9.18 | 417 | 285001 | 188122 | 70454904 |
Dysphagia | 88.82 | 9.18 | 766 | 284652 | 112068 | 70530958 |
Ejection fraction | 88.34 | 9.18 | 66 | 285352 | 1696 | 70641330 |
Hepatic enzyme increased | 83.75 | 9.18 | 336 | 285082 | 156654 | 70486372 |
Nephrogenic anaemia | 83.10 | 9.18 | 87 | 285331 | 3531 | 70639495 |
Gamma-glutamyltransferase increased | 78.92 | 9.18 | 408 | 285010 | 50277 | 70592749 |
Psoriatic arthropathy | 78.23 | 9.18 | 87 | 285331 | 64684 | 70578342 |
Gastric polyps | 78.10 | 9.18 | 82 | 285336 | 3339 | 70639687 |
Drug resistance | 78.03 | 9.18 | 28 | 285390 | 38162 | 70604864 |
Inappropriate antidiuretic hormone secretion | 77.65 | 9.18 | 238 | 285180 | 23038 | 70619988 |
Hepatic cytolysis | 77.33 | 9.18 | 210 | 285208 | 18982 | 70624044 |
Therapeutic product effect decreased | 75.71 | 9.18 | 307 | 285111 | 142711 | 70500315 |
Pancreatitis acute | 75.31 | 9.18 | 371 | 285047 | 44853 | 70598173 |
Rhinitis allergic | 74.41 | 9.18 | 134 | 285284 | 9161 | 70633865 |
Hypertensive nephropathy | 73.23 | 9.18 | 45 | 285373 | 829 | 70642197 |
C-reactive protein abnormal | 72.73 | 9.18 | 32 | 285386 | 38547 | 70604479 |
Abdominal pain upper | 71.76 | 9.18 | 1136 | 284282 | 192466 | 70450560 |
Hiatus hernia | 71.35 | 9.18 | 217 | 285201 | 20917 | 70622109 |
Affect lability | 68.49 | 9.18 | 136 | 285282 | 10010 | 70633016 |
Intentional overdose | 68.08 | 9.18 | 188 | 285230 | 98247 | 70544779 |
Motor dysfunction | 67.32 | 9.18 | 157 | 285261 | 12913 | 70630113 |
COVID-19 | 66.62 | 9.18 | 211 | 285207 | 105546 | 70537480 |
Hypergastrinaemia | 66.59 | 9.18 | 26 | 285392 | 163 | 70642863 |
Fatigue | 65.60 | 9.18 | 2683 | 282735 | 821636 | 69821390 |
Vascular purpura | 64.81 | 9.18 | 67 | 285351 | 2679 | 70640347 |
Acute generalised exanthematous pustulosis | 64.58 | 9.18 | 171 | 285247 | 15226 | 70627800 |
Gastritis | 63.33 | 9.18 | 350 | 285068 | 44241 | 70598785 |
Hypokalaemia | 62.27 | 9.18 | 804 | 284614 | 130384 | 70512642 |
Sleep disorder due to general medical condition, insomnia type | 62.24 | 9.18 | 33 | 285385 | 35699 | 70607327 |
Coordination abnormal | 60.97 | 9.18 | 172 | 285246 | 15894 | 70627132 |
Lung disorder | 60.70 | 9.18 | 483 | 284935 | 69001 | 70574025 |
Product use issue | 58.74 | 9.18 | 453 | 284965 | 179484 | 70463542 |
Bronchial neoplasm | 57.22 | 9.18 | 31 | 285387 | 445 | 70642581 |
Cholestatic liver injury | 57.13 | 9.18 | 77 | 285341 | 4091 | 70638935 |
Therapy non-responder | 56.92 | 9.18 | 142 | 285276 | 76773 | 70566253 |
Sensory loss | 55.38 | 9.18 | 134 | 285284 | 11285 | 70631741 |
Irritable bowel syndrome | 54.38 | 9.18 | 75 | 285343 | 50775 | 70592251 |
Systemic lupus erythematosus rash | 54.18 | 9.18 | 48 | 285370 | 1579 | 70641447 |
Jaundice | 53.88 | 9.18 | 366 | 285052 | 49742 | 70593284 |
Nephrectomy | 51.85 | 9.18 | 49 | 285369 | 1754 | 70641272 |
Pain | 51.57 | 9.18 | 2039 | 283379 | 626777 | 70016249 |
Anaemia | 51.56 | 9.18 | 2048 | 283370 | 401375 | 70241651 |
Blister | 51.20 | 9.18 | 219 | 285199 | 100307 | 70542719 |
Dermatitis bullous | 50.81 | 9.18 | 139 | 285279 | 12618 | 70630408 |
Cross sensitivity reaction | 50.36 | 9.18 | 66 | 285352 | 3412 | 70639614 |
Hypothyroidism | 50.27 | 9.18 | 336 | 285082 | 45419 | 70597607 |
Condition aggravated | 50.02 | 9.18 | 1324 | 284094 | 426311 | 70216715 |
Hyperkalaemia | 49.63 | 9.18 | 651 | 284767 | 105940 | 70537086 |
Pancreatitis | 49.59 | 9.18 | 426 | 284992 | 62242 | 70580784 |
Hypersensitivity | 48.61 | 9.18 | 642 | 284776 | 229170 | 70413856 |
Gallbladder disorder | 48.20 | 9.18 | 169 | 285249 | 17543 | 70625483 |
Lower respiratory tract infection | 48.13 | 9.18 | 259 | 285159 | 111654 | 70531372 |
Loss of employment | 47.78 | 9.18 | 52 | 285366 | 2207 | 70640819 |
Presbyacusis | 47.77 | 9.18 | 56 | 285362 | 2581 | 70640445 |
Thrombocytopenia | 47.69 | 9.18 | 1280 | 284138 | 237830 | 70405196 |
Epigastric discomfort | 47.68 | 9.18 | 96 | 285322 | 7137 | 70635889 |
Nephropathy | 47.65 | 9.18 | 108 | 285310 | 8717 | 70634309 |
Pregnancy | 47.63 | 9.18 | 18 | 285400 | 23763 | 70619263 |
Hepatitis cholestatic | 47.59 | 9.18 | 135 | 285283 | 12515 | 70630511 |
Cell death | 46.39 | 9.18 | 70 | 285348 | 4130 | 70638896 |
Mobility decreased | 45.06 | 9.18 | 237 | 285181 | 102762 | 70540264 |
Hepatojugular reflux | 44.98 | 9.18 | 29 | 285389 | 583 | 70642443 |
Rhabdomyolysis | 44.64 | 9.18 | 585 | 284833 | 95175 | 70547851 |
Ill-defined disorder | 43.75 | 9.18 | 97 | 285321 | 54644 | 70588382 |
Eating disorder | 43.68 | 9.18 | 169 | 285249 | 18396 | 70624630 |
Device expulsion | 42.65 | 9.18 | 18 | 285400 | 22228 | 70620798 |
Sedation complication | 42.30 | 9.18 | 3 | 285415 | 13407 | 70629619 |
Angina pectoris | 42.08 | 9.18 | 336 | 285082 | 48047 | 70594979 |
Knee arthroplasty | 41.50 | 9.18 | 46 | 285372 | 34255 | 70608771 |
Pleural thickening | 41.41 | 9.18 | 54 | 285364 | 2778 | 70640248 |
Abdominal discomfort | 41.01 | 9.18 | 612 | 284806 | 214046 | 70428980 |
Diabetic nephropathy | 40.74 | 9.18 | 53 | 285365 | 2720 | 70640306 |
Sleep apnoea syndrome | 40.74 | 9.18 | 248 | 285170 | 32465 | 70610561 |
Hip arthroplasty | 40.52 | 9.18 | 32 | 285386 | 28008 | 70615018 |
Therapy interrupted | 40.21 | 9.18 | 25 | 285393 | 24777 | 70618249 |
Nasal turbinate hypertrophy | 40.16 | 9.18 | 27 | 285391 | 584 | 70642442 |
Carpal tunnel syndrome | 39.91 | 9.18 | 155 | 285263 | 16902 | 70626124 |
Cholecystitis | 39.72 | 9.18 | 177 | 285241 | 20524 | 70622502 |
Mixed liver injury | 38.90 | 9.18 | 81 | 285337 | 6168 | 70636858 |
Bone erosion | 38.90 | 9.18 | 7 | 285411 | 15166 | 70627860 |
Therapeutic response decreased | 38.67 | 9.18 | 114 | 285304 | 58339 | 70584687 |
Aphasia | 38.52 | 9.18 | 302 | 285116 | 42947 | 70600079 |
Gallbladder injury | 38.39 | 9.18 | 34 | 285384 | 1118 | 70641908 |
Iron deficiency anaemia | 38.21 | 9.18 | 189 | 285229 | 22883 | 70620143 |
Occult blood | 38.08 | 9.18 | 38 | 285380 | 1456 | 70641570 |
Pleural fibrosis | 37.47 | 9.18 | 63 | 285355 | 4076 | 70638950 |
Degenerative mitral valve disease | 37.34 | 9.18 | 19 | 285399 | 238 | 70642788 |
Cardiac failure | 37.29 | 9.18 | 797 | 284621 | 142744 | 70500282 |
Premature delivery | 36.63 | 9.18 | 20 | 285398 | 21284 | 70621742 |
Dyspepsia | 36.57 | 9.18 | 532 | 284886 | 88545 | 70554481 |
Poisoning | 36.40 | 9.18 | 23 | 285395 | 22599 | 70620427 |
Neutropenic sepsis | 36.31 | 9.18 | 28 | 285390 | 24802 | 70618224 |
Device dependence | 35.93 | 9.18 | 12 | 285406 | 44 | 70642982 |
Hemiparesis | 35.72 | 9.18 | 233 | 285185 | 31236 | 70611790 |
Injection site pain | 35.66 | 9.18 | 302 | 285116 | 117317 | 70525709 |
Musculoskeletal stiffness | 35.30 | 9.18 | 402 | 285016 | 147358 | 70495668 |
Cardiac arrest | 35.08 | 9.18 | 443 | 284975 | 159391 | 70483635 |
Face oedema | 34.91 | 9.18 | 199 | 285219 | 25440 | 70617586 |
Accidental exposure to product | 34.62 | 9.18 | 37 | 285381 | 28014 | 70615012 |
Stomatitis | 34.61 | 9.18 | 340 | 285078 | 128171 | 70514855 |
Endometrial ablation | 34.58 | 9.18 | 28 | 285390 | 812 | 70642214 |
Nasopharyngitis | 34.16 | 9.18 | 659 | 284759 | 221547 | 70421479 |
Eczema | 34.11 | 9.18 | 243 | 285175 | 33538 | 70609488 |
Myelosuppression | 33.72 | 9.18 | 43 | 285375 | 30102 | 70612924 |
Haematotoxicity | 33.60 | 9.18 | 7 | 285411 | 13667 | 70629359 |
Red blood cell sedimentation rate abnormal | 33.36 | 9.18 | 18 | 285400 | 19285 | 70623741 |
Blood magnesium increased | 33.27 | 9.18 | 53 | 285365 | 3278 | 70639748 |
Osteosclerosis | 33.02 | 9.18 | 56 | 285362 | 3649 | 70639377 |
Cholangitis | 33.00 | 9.18 | 112 | 285306 | 11437 | 70631589 |
Neurotoxicity | 32.89 | 9.18 | 43 | 285375 | 29783 | 70613243 |
Muscle haemorrhage | 32.88 | 9.18 | 73 | 285345 | 5811 | 70637215 |
Weight increased | 32.74 | 9.18 | 734 | 284684 | 241597 | 70401429 |
Drug hypersensitivity | 32.67 | 9.18 | 805 | 284613 | 261654 | 70381372 |
Nephritic syndrome | 32.57 | 9.18 | 19 | 285399 | 317 | 70642709 |
Disease progression | 31.91 | 9.18 | 441 | 284977 | 156231 | 70486795 |
Drug ineffective for unapproved indication | 31.86 | 9.18 | 67 | 285351 | 38471 | 70604555 |
Tenosynovitis stenosans | 31.83 | 9.18 | 43 | 285375 | 2290 | 70640736 |
Sudden death | 31.71 | 9.18 | 168 | 285250 | 20896 | 70622130 |
Chronic kidney disease-mineral and bone disorder | 31.17 | 9.18 | 24 | 285394 | 646 | 70642380 |
Hepatitis | 30.69 | 9.18 | 322 | 285096 | 49658 | 70593368 |
Electrocardiogram Q wave abnormal | 30.17 | 9.18 | 22 | 285396 | 544 | 70642482 |
Urate nephropathy | 30.09 | 9.18 | 14 | 285404 | 142 | 70642884 |
Chest pain | 30.07 | 9.18 | 1267 | 284151 | 249993 | 70393033 |
Cholelithiasis | 30.02 | 9.18 | 307 | 285111 | 47033 | 70595993 |
Arterial occlusive disease | 29.49 | 9.18 | 83 | 285335 | 7659 | 70635367 |
Phlebitis | 29.42 | 9.18 | 86 | 285332 | 8108 | 70634918 |
Drug interaction | 29.39 | 9.18 | 1844 | 283574 | 379597 | 70263429 |
Occupational dermatitis | 29.10 | 9.18 | 13 | 285405 | 119 | 70642907 |
Post transplant lymphoproliferative disorder | 28.99 | 9.18 | 4 | 285414 | 10541 | 70632485 |
Anaemia macrocytic | 28.85 | 9.18 | 64 | 285354 | 5091 | 70637935 |
Malnutrition | 28.53 | 9.18 | 159 | 285259 | 20158 | 70622868 |
Bronchial haemorrhage | 28.27 | 9.18 | 30 | 285388 | 1237 | 70641789 |
Dry eye | 27.97 | 9.18 | 224 | 285194 | 32058 | 70610968 |
Eosinophilic fasciitis | 27.96 | 9.18 | 16 | 285402 | 257 | 70642769 |
Respiratory arrest | 27.76 | 9.18 | 117 | 285301 | 53816 | 70589210 |
Medication error | 27.75 | 9.18 | 126 | 285292 | 56786 | 70586240 |
Muscle contractions involuntary | 27.71 | 9.18 | 49 | 285369 | 3302 | 70639724 |
Oesophagitis ulcerative | 27.53 | 9.18 | 26 | 285392 | 930 | 70642096 |
Palpitations | 27.50 | 9.18 | 611 | 284807 | 110142 | 70532884 |
Rash | 27.46 | 9.18 | 1729 | 283689 | 508833 | 70134193 |
Gastric disorder | 27.14 | 9.18 | 228 | 285190 | 33094 | 70609932 |
Adverse drug reaction | 26.67 | 9.18 | 117 | 285301 | 53227 | 70589799 |
Abdominal pain | 26.54 | 9.18 | 1655 | 283763 | 340472 | 70302554 |
Respiratory distress | 26.36 | 9.18 | 336 | 285082 | 54314 | 70588712 |
Synovial fluid analysis | 26.34 | 9.18 | 35 | 285383 | 1834 | 70641192 |
Muscle spasticity | 26.27 | 9.18 | 152 | 285266 | 19537 | 70623489 |
Respiratory depression | 26.17 | 9.18 | 37 | 285381 | 24794 | 70618232 |
Gallbladder polyp | 26.15 | 9.18 | 25 | 285393 | 908 | 70642118 |
Hepatotoxicity | 26.14 | 9.18 | 90 | 285328 | 43896 | 70599130 |
Erythema dyschromicum perstans | 26.12 | 9.18 | 10 | 285408 | 59 | 70642967 |
Eosinophilic colitis | 25.85 | 9.18 | 18 | 285400 | 413 | 70642613 |
Pulmonary vascular disorder | 25.68 | 9.18 | 25 | 285393 | 929 | 70642097 |
Bronchial disorder | 25.67 | 9.18 | 39 | 285379 | 2315 | 70640711 |
Ventricular hypokinesia | 25.57 | 9.18 | 82 | 285336 | 8130 | 70634896 |
Injection site erythema | 25.50 | 9.18 | 180 | 285238 | 72744 | 70570282 |
Blood alkaline phosphatase increased | 25.41 | 9.18 | 353 | 285065 | 58168 | 70584858 |
Renal disorder | 25.32 | 9.18 | 249 | 285169 | 37760 | 70605266 |
Neuroleptic malignant syndrome | 25.24 | 9.18 | 41 | 285377 | 25966 | 70617060 |
Live birth | 25.08 | 9.18 | 12 | 285406 | 13767 | 70629259 |
Laboratory test abnormal | 24.79 | 9.18 | 41 | 285377 | 25782 | 70617244 |
Anxiety | 24.79 | 9.18 | 1104 | 284314 | 219226 | 70423800 |
Idiopathic pulmonary fibrosis | 24.68 | 9.18 | 58 | 285360 | 4793 | 70638233 |
Drug dependence | 24.53 | 9.18 | 73 | 285345 | 37248 | 70605778 |
Hyperthermia | 24.44 | 9.18 | 132 | 285286 | 16539 | 70626487 |
Hypoparathyroidism | 24.40 | 9.18 | 25 | 285393 | 989 | 70642037 |
Tetany | 24.09 | 9.18 | 37 | 285381 | 2217 | 70640809 |
Nicotine dependence | 24.05 | 9.18 | 23 | 285395 | 836 | 70642190 |
Product dose omission issue | 23.89 | 9.18 | 679 | 284739 | 216789 | 70426237 |
Inferior vena cava dilatation | 23.74 | 9.18 | 22 | 285396 | 768 | 70642258 |
Lip oedema | 23.41 | 9.18 | 62 | 285356 | 5521 | 70637505 |
Febrile bone marrow aplasia | 23.36 | 9.18 | 103 | 285315 | 11888 | 70631138 |
Aggression | 23.18 | 9.18 | 108 | 285310 | 48338 | 70594688 |
Dermatitis exfoliative | 23.17 | 9.18 | 94 | 285324 | 10457 | 70632569 |
Sinus congestion | 23.10 | 9.18 | 134 | 285284 | 17239 | 70625787 |
Oesophagitis | 22.90 | 9.18 | 163 | 285255 | 22489 | 70620537 |
Caesarean section | 22.89 | 9.18 | 9 | 285409 | 11598 | 70631428 |
Pancreatic neuroendocrine tumour | 22.70 | 9.18 | 20 | 285398 | 653 | 70642373 |
Renal cyst | 22.58 | 9.18 | 110 | 285308 | 13235 | 70629791 |
Bunion operation | 22.44 | 9.18 | 22 | 285396 | 825 | 70642201 |
Nephrosclerosis | 22.39 | 9.18 | 31 | 285387 | 1690 | 70641336 |
Acute coronary syndrome | 22.38 | 9.18 | 148 | 285270 | 19931 | 70623095 |
Pyelocaliectasis | 22.37 | 9.18 | 22 | 285396 | 828 | 70642198 |
Cerebral haematoma | 22.37 | 9.18 | 73 | 285345 | 7305 | 70635721 |
Axonal neuropathy | 22.33 | 9.18 | 33 | 285385 | 1911 | 70641115 |
Deafness neurosensory | 22.29 | 9.18 | 68 | 285350 | 6564 | 70636462 |
Mucormycosis | 22.13 | 9.18 | 3 | 285415 | 8011 | 70635015 |
Injection site pruritus | 22.12 | 9.18 | 82 | 285336 | 39128 | 70603898 |
Sleep disorder due to a general medical condition | 21.96 | 9.18 | 92 | 285326 | 10384 | 70632642 |
Ejection fraction abnormal | 21.81 | 9.18 | 31 | 285387 | 1732 | 70641294 |
Vitamin B12 deficiency | 21.75 | 9.18 | 63 | 285355 | 5909 | 70637117 |
Cardiac disorder | 21.74 | 9.18 | 348 | 285070 | 59067 | 70583959 |
Systolic dysfunction | 21.71 | 9.18 | 45 | 285373 | 3416 | 70639610 |
Bone cyst | 21.20 | 9.18 | 40 | 285378 | 2834 | 70640192 |
Injection site bruising | 21.16 | 9.18 | 80 | 285338 | 37952 | 70605074 |
Ureteric compression | 21.13 | 9.18 | 13 | 285405 | 240 | 70642786 |
Carotid artery stenosis | 21.06 | 9.18 | 77 | 285341 | 8159 | 70634867 |
Hepatic haematoma | 20.99 | 9.18 | 21 | 285397 | 807 | 70642219 |
Eyelid oedema | 20.89 | 9.18 | 104 | 285314 | 12623 | 70630403 |
Radiation pneumonitis | 20.84 | 9.18 | 46 | 285372 | 3647 | 70639379 |
Respiratory tract congestion | 20.83 | 9.18 | 132 | 285286 | 17521 | 70625505 |
Hyperchlorhydria | 20.72 | 9.18 | 31 | 285387 | 1815 | 70641211 |
Mesenteric panniculitis | 20.71 | 9.18 | 13 | 285405 | 249 | 70642777 |
Pathogen resistance | 20.69 | 9.18 | 14 | 285404 | 13265 | 70629761 |
Hyperparathyroidism secondary | 20.63 | 9.18 | 37 | 285381 | 2521 | 70640505 |
Contusion | 20.50 | 9.18 | 377 | 285041 | 127659 | 70515367 |
Hyperlipidaemia | 20.35 | 9.18 | 165 | 285253 | 23698 | 70619328 |
Scleritis | 20.31 | 9.18 | 45 | 285373 | 3577 | 70639449 |
Hypovitaminosis | 20.29 | 9.18 | 23 | 285395 | 1022 | 70642004 |
Abortion spontaneous | 20.28 | 9.18 | 48 | 285370 | 26431 | 70616595 |
Infection | 20.25 | 9.18 | 670 | 284748 | 210115 | 70432911 |
Rectosigmoid cancer | 20.13 | 9.18 | 13 | 285405 | 262 | 70642764 |
Fall | 20.13 | 9.18 | 2061 | 283357 | 442035 | 70200991 |
Ocular myasthenia | 20.02 | 9.18 | 15 | 285403 | 387 | 70642639 |
Granulomatous rosacea | 20.02 | 9.18 | 12 | 285406 | 211 | 70642815 |
Hepatic encephalopathy | 20.00 | 9.18 | 155 | 285263 | 21963 | 70621063 |
Renal tubular disorder | 19.94 | 9.18 | 62 | 285356 | 6048 | 70636978 |
Impaired healing | 19.92 | 9.18 | 197 | 285221 | 74177 | 70568849 |
Deformity | 19.91 | 9.18 | 76 | 285342 | 8221 | 70634805 |
Campylobacter colitis | 19.74 | 9.18 | 7 | 285411 | 32 | 70642994 |
Arthralgia | 19.66 | 9.18 | 1751 | 283667 | 501639 | 70141387 |
Injection site swelling | 19.60 | 9.18 | 98 | 285320 | 43059 | 70599967 |
Rebound acid hypersecretion | 19.46 | 9.18 | 9 | 285409 | 90 | 70642936 |
Obesity | 19.35 | 9.18 | 50 | 285368 | 26721 | 70616305 |
Bicytopenia | 19.25 | 9.18 | 47 | 285371 | 3981 | 70639045 |
Unresponsive to stimuli | 19.24 | 9.18 | 126 | 285292 | 51805 | 70591221 |
Osteopenia | 19.18 | 9.18 | 124 | 285294 | 16573 | 70626453 |
Drug eruption | 19.12 | 9.18 | 243 | 285175 | 39253 | 70603773 |
Helicobacter test positive | 19.01 | 9.18 | 24 | 285394 | 1195 | 70641831 |
Acute graft versus host disease in skin | 18.94 | 9.18 | 3 | 285415 | 7134 | 70635892 |
Acute pulmonary oedema | 18.86 | 9.18 | 105 | 285313 | 13307 | 70629719 |
Colitis microscopic | 18.81 | 9.18 | 79 | 285339 | 8926 | 70634100 |
Febrile neutropenia | 18.79 | 9.18 | 653 | 284765 | 203665 | 70439361 |
Occupational exposure to air contaminants | 18.74 | 9.18 | 10 | 285408 | 139 | 70642887 |
Stevens-Johnson syndrome | 18.71 | 9.18 | 224 | 285194 | 35683 | 70607343 |
Duodenal polyp | 18.68 | 9.18 | 13 | 285405 | 298 | 70642728 |
Dialysis | 18.64 | 9.18 | 127 | 285291 | 17275 | 70625751 |
Heat stroke | 18.63 | 9.18 | 27 | 285391 | 1536 | 70641490 |
Haematoma | 18.63 | 9.18 | 286 | 285132 | 48132 | 70594894 |
Genital infection female | 18.63 | 9.18 | 8 | 285410 | 66 | 70642960 |
Gastric antral vascular ectasia | 18.59 | 9.18 | 20 | 285398 | 838 | 70642188 |
Impaired work ability | 18.56 | 9.18 | 121 | 285297 | 16219 | 70626807 |
Immune reconstitution inflammatory syndrome | 18.55 | 9.18 | 15 | 285403 | 12975 | 70630051 |
Mucosal inflammation | 18.47 | 9.18 | 179 | 285239 | 67671 | 70575355 |
Bradypnoea | 18.37 | 9.18 | 56 | 285362 | 5403 | 70637623 |
Therapy partial responder | 18.32 | 9.18 | 14 | 285404 | 12460 | 70630566 |
Type I hypersensitivity | 18.32 | 9.18 | 44 | 285374 | 3688 | 70639338 |
Dystonia | 18.26 | 9.18 | 32 | 285386 | 19674 | 70623352 |
Disability | 18.23 | 9.18 | 20 | 285398 | 14963 | 70628063 |
Essential hypertension | 18.22 | 9.18 | 56 | 285362 | 5428 | 70637598 |
Thrombocytopenic purpura | 18.17 | 9.18 | 33 | 285385 | 2271 | 70640755 |
Hepatic function abnormal | 18.12 | 9.18 | 379 | 285039 | 67617 | 70575409 |
Renal tubular necrosis | 18.05 | 9.18 | 157 | 285261 | 23014 | 70620012 |
Phaeochromocytoma malignant | 18.03 | 9.18 | 8 | 285410 | 72 | 70642954 |
Brain scan abnormal | 18.01 | 9.18 | 23 | 285395 | 1159 | 70641867 |
Suicide attempt | 17.95 | 9.18 | 219 | 285199 | 79291 | 70563735 |
Transient ischaemic attack | 17.91 | 9.18 | 272 | 285146 | 45672 | 70597354 |
Electric shock | 17.81 | 9.18 | 23 | 285395 | 1172 | 70641854 |
Type III immune complex mediated reaction | 17.75 | 9.18 | 17 | 285401 | 619 | 70642407 |
Ischaemic stroke | 17.73 | 9.18 | 196 | 285222 | 30624 | 70612402 |
Angina bullosa haemorrhagica | 17.70 | 9.18 | 11 | 285407 | 207 | 70642819 |
Immunodeficiency | 17.68 | 9.18 | 27 | 285391 | 17528 | 70625498 |
Eructation | 17.64 | 9.18 | 82 | 285336 | 9678 | 70633348 |
Chronic graft versus host disease | 17.63 | 9.18 | 3 | 285415 | 6767 | 70636259 |
Kidney infection | 17.40 | 9.18 | 136 | 285282 | 19319 | 70623707 |
Chronic cutaneous lupus erythematosus | 17.33 | 9.18 | 13 | 285405 | 336 | 70642690 |
Fear of injection | 17.28 | 9.18 | 3 | 285415 | 6669 | 70636357 |
Burning sensation | 17.27 | 9.18 | 304 | 285114 | 52566 | 70590460 |
Hyperkinetic heart syndrome | 17.26 | 9.18 | 9 | 285409 | 119 | 70642907 |
Cataract | 17.13 | 9.18 | 317 | 285101 | 55328 | 70587698 |
Crepitations | 17.09 | 9.18 | 75 | 285343 | 8639 | 70634387 |
Memory impairment | 17.03 | 9.18 | 266 | 285152 | 92375 | 70550651 |
Angina unstable | 17.03 | 9.18 | 116 | 285302 | 15777 | 70627249 |
Venoocclusive liver disease | 16.98 | 9.18 | 11 | 285407 | 10667 | 70632359 |
Synovial cyst | 16.96 | 9.18 | 75 | 285343 | 8667 | 70634359 |
Carotid arteriosclerosis | 16.95 | 9.18 | 33 | 285385 | 2394 | 70640632 |
Eye injury | 16.92 | 9.18 | 27 | 285391 | 1672 | 70641354 |
Rash scarlatiniform | 16.85 | 9.18 | 11 | 285407 | 226 | 70642800 |
Nausea | 16.84 | 9.18 | 3772 | 281646 | 848316 | 69794710 |
Gastric cancer | 16.75 | 9.18 | 76 | 285342 | 8879 | 70634147 |
Psoriasis | 16.65 | 9.18 | 287 | 285131 | 98146 | 70544880 |
Rhinitis | 16.64 | 9.18 | 91 | 285327 | 11456 | 70631570 |
Hyperphosphatasaemia | 16.63 | 9.18 | 8 | 285410 | 88 | 70642938 |
Pre-eclampsia | 16.61 | 9.18 | 3 | 285415 | 6482 | 70636544 |
Nerve injury | 16.60 | 9.18 | 72 | 285346 | 8252 | 70634774 |
Cerebellar haematoma | 16.54 | 9.18 | 16 | 285402 | 590 | 70642436 |
Diverticulum | 16.54 | 9.18 | 103 | 285315 | 13590 | 70629436 |
Gastroenteritis eosinophilic | 16.48 | 9.18 | 11 | 285407 | 235 | 70642791 |
Tongue oedema | 16.41 | 9.18 | 59 | 285359 | 6200 | 70636826 |
Prescription form tampering | 16.35 | 9.18 | 13 | 285405 | 367 | 70642659 |
Nephropathy toxic | 16.32 | 9.18 | 31 | 285387 | 18483 | 70624543 |
Cardiac aneurysm | 16.31 | 9.18 | 24 | 285394 | 1384 | 70641642 |
Helicobacter gastritis | 16.27 | 9.18 | 32 | 285386 | 2339 | 70640687 |
Tachycardia | 16.17 | 9.18 | 500 | 284918 | 158046 | 70484980 |
Rheumatoid nodule | 16.16 | 9.18 | 110 | 285308 | 14957 | 70628069 |
Regurgitation | 16.15 | 9.18 | 31 | 285387 | 2225 | 70640801 |
Premature labour | 16.11 | 9.18 | 6 | 285412 | 7994 | 70635032 |
Microcytic anaemia | 16 | 9.18 | 49 | 285369 | 4740 | 70638286 |
Gastrointestinal motility disorder | 15.92 | 9.18 | 54 | 285364 | 5512 | 70637514 |
Gangrene | 15.91 | 9.18 | 71 | 285347 | 8238 | 70634788 |
Subacute cutaneous lupus erythematosus | 15.90 | 9.18 | 38 | 285380 | 3175 | 70639851 |
Creatinine renal clearance decreased | 15.88 | 9.18 | 28 | 285390 | 17172 | 70625854 |
CSF volume increased | 15.87 | 9.18 | 6 | 285412 | 34 | 70642992 |
Substance abuse | 15.83 | 9.18 | 10 | 285408 | 9827 | 70633199 |
Nipple swelling | 15.74 | 9.18 | 8 | 285410 | 100 | 70642926 |
Thrombophlebitis | 15.71 | 9.18 | 56 | 285362 | 5860 | 70637166 |
Coronary artery stenosis | 15.61 | 9.18 | 90 | 285328 | 11554 | 70631472 |
Nerve degeneration | 15.51 | 9.18 | 11 | 285407 | 260 | 70642766 |
Schizophreniform disorder | 15.43 | 9.18 | 9 | 285409 | 150 | 70642876 |
Dehydration | 15.37 | 9.18 | 1082 | 284336 | 225060 | 70417966 |
Occupational exposure to product | 15.31 | 9.18 | 17 | 285401 | 738 | 70642288 |
Diverticulum oesophageal | 15.28 | 9.18 | 9 | 285409 | 153 | 70642873 |
Escherichia pyelonephritis | 15.27 | 9.18 | 14 | 285404 | 482 | 70642544 |
Localised infection | 15.23 | 9.18 | 75 | 285343 | 33083 | 70609943 |
Urticaria papular | 15.23 | 9.18 | 9 | 285409 | 154 | 70642872 |
Duodenitis | 15.08 | 9.18 | 62 | 285356 | 6940 | 70636086 |
Sedation | 15.07 | 9.18 | 118 | 285300 | 46613 | 70596413 |
Physical examination abnormal | 15.02 | 9.18 | 11 | 285407 | 274 | 70642752 |
Allergy to chemicals | 15.00 | 9.18 | 28 | 285390 | 1968 | 70641058 |
Renal impairment | 14.84 | 9.18 | 715 | 284703 | 143222 | 70499804 |
Gait inability | 14.80 | 9.18 | 120 | 285298 | 47055 | 70595971 |
Liver disorder | 14.76 | 9.18 | 338 | 285080 | 61230 | 70581796 |
High frequency ablation | 14.74 | 9.18 | 11 | 285407 | 282 | 70642744 |
Psychotic disorder | 14.72 | 9.18 | 90 | 285328 | 37611 | 70605415 |
Hypocapnia | 14.71 | 9.18 | 15 | 285403 | 590 | 70642436 |
Purging | 14.69 | 9.18 | 6 | 285412 | 43 | 70642983 |
Cerebral infarction | 14.66 | 9.18 | 249 | 285169 | 42760 | 70600266 |
Septic shock | 14.54 | 9.18 | 571 | 284847 | 111687 | 70531339 |
IIIrd nerve paresis | 14.54 | 9.18 | 9 | 285409 | 168 | 70642858 |
Subdural haematoma | 14.50 | 9.18 | 181 | 285237 | 29117 | 70613909 |
Acute hepatitis B | 14.44 | 9.18 | 13 | 285405 | 437 | 70642589 |
Cutaneous lupus erythematosus | 14.44 | 9.18 | 34 | 285384 | 2814 | 70640212 |
Cardiotoxicity | 14.34 | 9.18 | 14 | 285404 | 11056 | 70631970 |
Antinuclear antibody positive | 14.32 | 9.18 | 60 | 285358 | 6773 | 70636253 |
Vulvovaginal burning sensation | 14.25 | 9.18 | 21 | 285397 | 1213 | 70641813 |
Transplant dysfunction | 14.23 | 9.18 | 5 | 285413 | 6904 | 70636122 |
Nasal discharge discolouration | 14.17 | 9.18 | 28 | 285390 | 2053 | 70640973 |
Anticoagulation drug level increased | 14.17 | 9.18 | 16 | 285402 | 708 | 70642318 |
Hunger | 14.12 | 9.18 | 47 | 285371 | 4751 | 70638275 |
Oesophageal adenocarcinoma | 14.12 | 9.18 | 17 | 285401 | 806 | 70642220 |
Pleuritic pain | 14.11 | 9.18 | 72 | 285346 | 8825 | 70634201 |
Flatulence | 14.10 | 9.18 | 224 | 285194 | 37957 | 70605069 |
Small cell carcinoma | 14.10 | 9.18 | 11 | 285407 | 302 | 70642724 |
Hyperkaliuria | 14.09 | 9.18 | 9 | 285409 | 178 | 70642848 |
Gastrinoma | 14.08 | 9.18 | 5 | 285413 | 23 | 70643003 |
Pancreatitis chronic | 14.06 | 9.18 | 40 | 285378 | 3714 | 70639312 |
Gallbladder hypofunction | 14.02 | 9.18 | 13 | 285405 | 454 | 70642572 |
Coronary artery disease | 13.99 | 9.18 | 341 | 285077 | 62395 | 70580631 |
Normal newborn | 13.97 | 9.18 | 4 | 285414 | 6296 | 70636730 |
Therapy cessation | 13.89 | 9.18 | 79 | 285339 | 33597 | 70609429 |
Haemorrhage intracranial | 13.86 | 9.18 | 52 | 285366 | 24725 | 70618301 |
Bile duct stone | 13.80 | 9.18 | 49 | 285369 | 5117 | 70637909 |
Cardiorenal syndrome | 13.76 | 9.18 | 23 | 285395 | 1481 | 70641545 |
Nephritis allergic | 13.76 | 9.18 | 15 | 285403 | 638 | 70642388 |
Blood test abnormal | 13.61 | 9.18 | 103 | 285315 | 14487 | 70628539 |
Exposure to toxic agent | 13.61 | 9.18 | 4 | 285414 | 6190 | 70636836 |
Loss of personal independence in daily activities | 13.59 | 9.18 | 250 | 285168 | 84660 | 70558366 |
Graft versus host disease in skin | 13.59 | 9.18 | 3 | 285415 | 5627 | 70637399 |
Tooth demineralisation | 13.56 | 9.18 | 3 | 285415 | 0 | 70643026 |
Erosive oesophagitis | 13.50 | 9.18 | 32 | 285386 | 2659 | 70640367 |
Erythema | 13.41 | 9.18 | 954 | 284464 | 198609 | 70444417 |
Melaena | 13.39 | 9.18 | 309 | 285109 | 56046 | 70586980 |
Injection site haemorrhage | 13.37 | 9.18 | 55 | 285363 | 25472 | 70617554 |
Cognitive disorder | 13.34 | 9.18 | 169 | 285249 | 60787 | 70582239 |
Haematoma muscle | 13.32 | 9.18 | 29 | 285389 | 2278 | 70640748 |
Cardiothoracic ratio increased | 13.24 | 9.18 | 6 | 285412 | 57 | 70642969 |
Alanine aminotransferase abnormal | 13.23 | 9.18 | 8 | 285410 | 8051 | 70634975 |
Cutaneous vasculitis | 13.22 | 9.18 | 61 | 285357 | 7177 | 70635849 |
Aspergillus infection | 13.20 | 9.18 | 33 | 285385 | 17835 | 70625191 |
Hypotension | 13.20 | 9.18 | 1425 | 283993 | 402956 | 70240070 |
Bronchopneumopathy | 13.19 | 9.18 | 15 | 285403 | 669 | 70642357 |
Renal hypertension | 13.14 | 9.18 | 9 | 285409 | 201 | 70642825 |
Oedema peripheral | 13.11 | 9.18 | 1077 | 284341 | 227014 | 70416012 |
Gastric ulcer | 13.09 | 9.18 | 190 | 285228 | 31600 | 70611426 |
Transplant rejection | 13.09 | 9.18 | 34 | 285384 | 18137 | 70624889 |
Vitreous detachment | 13.06 | 9.18 | 27 | 285391 | 2046 | 70640980 |
Diarrhoea | 12.99 | 9.18 | 3441 | 281977 | 779900 | 69863126 |
No adverse event | 12.95 | 9.18 | 76 | 285342 | 32077 | 70610949 |
Cholecystectomy | 12.95 | 9.18 | 68 | 285350 | 8429 | 70634597 |
Hyperuricaemia | 12.94 | 9.18 | 82 | 285336 | 10884 | 70632142 |
Gastric ulcer haemorrhage | 12.86 | 9.18 | 68 | 285350 | 8450 | 70634576 |
Intentional product misuse | 12.85 | 9.18 | 234 | 285184 | 79361 | 70563665 |
Uveal melanoma | 12.84 | 9.18 | 4 | 285414 | 11 | 70643015 |
Pneumobilia | 12.83 | 9.18 | 9 | 285409 | 209 | 70642817 |
Heart rate decreased | 12.82 | 9.18 | 174 | 285244 | 61841 | 70581185 |
Renal atrophy | 12.79 | 9.18 | 24 | 285394 | 1693 | 70641333 |
Pulmonary valve disease | 12.74 | 9.18 | 10 | 285408 | 277 | 70642749 |
Ventricular enlargement | 12.71 | 9.18 | 13 | 285405 | 513 | 70642513 |
Supraventricular extrasystoles | 12.66 | 9.18 | 54 | 285364 | 6144 | 70636882 |
Pleurisy | 12.65 | 9.18 | 75 | 285343 | 9724 | 70633302 |
Renal infarct | 12.55 | 9.18 | 30 | 285388 | 2507 | 70640519 |
Thymus disorder | 12.53 | 9.18 | 10 | 285408 | 284 | 70642742 |
Graft versus host disease | 12.52 | 9.18 | 26 | 285392 | 14997 | 70628029 |
Circumoral oedema | 12.50 | 9.18 | 10 | 285408 | 285 | 70642741 |
Angiopathy | 12.48 | 9.18 | 56 | 285362 | 6511 | 70636515 |
Seizure | 12.44 | 9.18 | 587 | 284831 | 177375 | 70465651 |
Blood lactic acid increased | 12.43 | 9.18 | 16 | 285402 | 11157 | 70631869 |
Adverse event | 12.43 | 9.18 | 133 | 285285 | 49328 | 70593698 |
Parkinsonism | 12.37 | 9.18 | 27 | 285391 | 15298 | 70627728 |
Schizophrenia | 12.37 | 9.18 | 31 | 285387 | 16737 | 70626289 |
Adrenocorticotropic hormone deficiency | 12.34 | 9.18 | 18 | 285400 | 1030 | 70641996 |
Tooth disorder | 12.33 | 9.18 | 149 | 285269 | 23789 | 70619237 |
Myoglobinaemia | 12.31 | 9.18 | 7 | 285411 | 111 | 70642915 |
Appendicitis | 12.29 | 9.18 | 31 | 285387 | 16702 | 70626324 |
Juvenile idiopathic arthritis | 12.29 | 9.18 | 4 | 285414 | 5796 | 70637230 |
Ulcer | 12.27 | 9.18 | 158 | 285260 | 25596 | 70617430 |
Asthenia | 12.21 | 9.18 | 2057 | 283361 | 455609 | 70187417 |
Infusion site scar | 12.21 | 9.18 | 10 | 285408 | 295 | 70642731 |
Dermatophytosis of nail | 12.19 | 9.18 | 8 | 285410 | 166 | 70642860 |
Drug use disorder | 12.16 | 9.18 | 9 | 285409 | 8142 | 70634884 |
Prurigo | 12.13 | 9.18 | 20 | 285398 | 1273 | 70641753 |
Neutrophilia | 12.10 | 9.18 | 7 | 285411 | 7214 | 70635812 |
Vertigo | 12.08 | 9.18 | 334 | 285084 | 62309 | 70580717 |
Dry mouth | 12.03 | 9.18 | 370 | 285048 | 70087 | 70572939 |
Intestinal infarction | 12.03 | 9.18 | 20 | 285398 | 1282 | 70641744 |
Inappropriate schedule of product administration | 12.01 | 9.18 | 335 | 285083 | 107220 | 70535806 |
Cardiac murmur functional | 11.99 | 9.18 | 5 | 285413 | 38 | 70642988 |
Cyst | 11.98 | 9.18 | 90 | 285328 | 12629 | 70630397 |
Cholecystitis acute | 11.95 | 9.18 | 86 | 285332 | 11908 | 70631118 |
Hypertriglyceridaemia | 11.94 | 9.18 | 85 | 285333 | 11726 | 70631300 |
Device use error | 11.93 | 9.18 | 6 | 285412 | 6690 | 70636336 |
Placental calcification | 11.91 | 9.18 | 4 | 285414 | 15 | 70643011 |
Teeth brittle | 11.85 | 9.18 | 12 | 285406 | 468 | 70642558 |
Cerebral artery thrombosis | 11.83 | 9.18 | 18 | 285400 | 1070 | 70641956 |
Unintentional medical device removal | 11.80 | 9.18 | 7 | 285411 | 7117 | 70635909 |
Bronchopulmonary aspergillosis | 11.80 | 9.18 | 44 | 285374 | 20958 | 70622068 |
Fixed eruption | 11.79 | 9.18 | 29 | 285389 | 2467 | 70640559 |
Clinically isolated syndrome | 11.77 | 9.18 | 5 | 285413 | 40 | 70642986 |
Shock haemorrhagic | 11.76 | 9.18 | 118 | 285300 | 17988 | 70625038 |
Lipase increased | 11.72 | 9.18 | 103 | 285315 | 15143 | 70627883 |
Wrong technique in product usage process | 11.72 | 9.18 | 200 | 285218 | 68498 | 70574528 |
Dermatitis exfoliative generalised | 11.68 | 9.18 | 54 | 285364 | 6360 | 70636666 |
Colitis ischaemic | 11.65 | 9.18 | 97 | 285321 | 14040 | 70628986 |
Tubulointerstitial nephritis and uveitis syndrome | 11.65 | 9.18 | 10 | 285408 | 315 | 70642711 |
Liver function test increased | 11.61 | 9.18 | 84 | 285334 | 33763 | 70609263 |
Blood gastrin increased | 11.56 | 9.18 | 5 | 285413 | 42 | 70642984 |
Food interaction | 11.54 | 9.18 | 22 | 285396 | 1571 | 70641455 |
Traumatic haematoma | 11.54 | 9.18 | 25 | 285393 | 1957 | 70641069 |
Hypoplastic anaemia | 11.51 | 9.18 | 4 | 285414 | 17 | 70643009 |
Platelet adhesiveness decreased | 11.49 | 9.18 | 3 | 285415 | 3 | 70643023 |
Overdose | 11.45 | 9.18 | 562 | 284856 | 169183 | 70473843 |
Vulval disorder | 11.44 | 9.18 | 12 | 285406 | 488 | 70642538 |
Prothrombin time ratio decreased | 11.44 | 9.18 | 15 | 285403 | 776 | 70642250 |
Haemorrhoids | 11.37 | 9.18 | 155 | 285263 | 25433 | 70617593 |
Chest expansion decreased | 11.36 | 9.18 | 8 | 285410 | 187 | 70642839 |
Lethargy | 11.29 | 9.18 | 224 | 285194 | 75026 | 70568000 |
Anal erythema | 11.29 | 9.18 | 8 | 285410 | 189 | 70642837 |
Product substitution issue | 11.24 | 9.18 | 119 | 285299 | 18394 | 70624632 |
Cytomegalovirus infection | 11.20 | 9.18 | 104 | 285314 | 39654 | 70603372 |
Hypoalbuminaemia | 11.18 | 9.18 | 122 | 285296 | 19000 | 70624026 |
Pruritus | 11.17 | 9.18 | 1570 | 283848 | 343990 | 70299036 |
Xerosis | 11.16 | 9.18 | 17 | 285401 | 1011 | 70642015 |
Creatinine renal clearance abnormal | 11.13 | 9.18 | 12 | 285406 | 504 | 70642522 |
Purple glove syndrome | 11.12 | 9.18 | 9 | 285409 | 261 | 70642765 |
Mitral valve incompetence | 11.11 | 9.18 | 160 | 285258 | 26568 | 70616458 |
Sinus disorder | 11.10 | 9.18 | 121 | 285297 | 18838 | 70624188 |
Enterochromaffin cell hyperplasia | 11.08 | 9.18 | 6 | 285412 | 86 | 70642940 |
Hypoparathyroidism secondary | 11.04 | 9.18 | 8 | 285410 | 196 | 70642830 |
Blood thyroid stimulating hormone increased | 11.02 | 9.18 | 65 | 285353 | 8414 | 70634612 |
Hyponatraemic seizure | 11.01 | 9.18 | 12 | 285406 | 510 | 70642516 |
Epstein-Barr virus infection | 10.86 | 9.18 | 23 | 285395 | 13175 | 70629851 |
Abdominal strangulated hernia | 10.84 | 9.18 | 6 | 285412 | 90 | 70642936 |
Enterocolitis haemorrhagic | 10.82 | 9.18 | 25 | 285393 | 2043 | 70640983 |
Therapeutic product effect incomplete | 10.82 | 9.18 | 384 | 285034 | 119498 | 70523528 |
Multi-organ disorder | 10.79 | 9.18 | 27 | 285391 | 2322 | 70640704 |
Breast cancer stage II | 10.78 | 9.18 | 4 | 285414 | 5342 | 70637684 |
Complication of device insertion | 10.74 | 9.18 | 4 | 285414 | 5328 | 70637698 |
Respiratory syncytial virus infection | 10.73 | 9.18 | 9 | 285409 | 7646 | 70635380 |
Brief psychotic disorder with marked stressors | 10.61 | 9.18 | 9 | 285409 | 279 | 70642747 |
Drug specific antibody present | 10.50 | 9.18 | 5 | 285413 | 5753 | 70637273 |
Dermatosis | 10.46 | 9.18 | 12 | 285406 | 540 | 70642486 |
Photophobia | 10.45 | 9.18 | 118 | 285300 | 18532 | 70624494 |
Idiosyncratic drug reaction | 10.45 | 9.18 | 18 | 285400 | 1188 | 70641838 |
Campylobacter gastroenteritis | 10.44 | 9.18 | 18 | 285400 | 1189 | 70641837 |
Bladder cancer | 10.43 | 9.18 | 35 | 285383 | 17207 | 70625819 |
Systemic infection | 10.39 | 9.18 | 7 | 285411 | 6650 | 70636376 |
Toxic epidermal necrolysis | 10.38 | 9.18 | 220 | 285198 | 39337 | 70603689 |
Oesophageal candidiasis | 10.28 | 9.18 | 64 | 285354 | 8443 | 70634583 |
Hallucination, olfactory | 10.24 | 9.18 | 11 | 285407 | 460 | 70642566 |
Coagulation factor decreased | 10.23 | 9.18 | 7 | 285411 | 156 | 70642870 |
Anaemia folate deficiency | 10.18 | 9.18 | 9 | 285409 | 295 | 70642731 |
Vulvovaginal erythema | 10.18 | 9.18 | 8 | 285410 | 222 | 70642804 |
Pericardial haemorrhage | 10.16 | 9.18 | 39 | 285379 | 4229 | 70638797 |
Aortic valve incompetence | 10.15 | 9.18 | 66 | 285352 | 8838 | 70634188 |
Facet joint syndrome | 10.13 | 9.18 | 6 | 285412 | 6107 | 70636919 |
Vulval oedema | 10.12 | 9.18 | 4 | 285414 | 26 | 70643000 |
Haematuria | 10.11 | 9.18 | 331 | 285087 | 63242 | 70579784 |
Drug tolerance | 10.09 | 9.18 | 9 | 285409 | 7419 | 70635607 |
Nocardiosis | 10.08 | 9.18 | 4 | 285414 | 5125 | 70637901 |
Brain injury | 10.06 | 9.18 | 17 | 285401 | 10600 | 70632426 |
Hepatocellular carcinoma | 10.05 | 9.18 | 73 | 285345 | 10135 | 70632891 |
Biliary tract disorder | 10.05 | 9.18 | 20 | 285398 | 1474 | 70641552 |
Sinus bradycardia | 10.05 | 9.18 | 142 | 285276 | 23481 | 70619545 |
Acute myeloid leukaemia | 10.03 | 9.18 | 78 | 285340 | 30862 | 70612164 |
Dyshidrotic eczema | 9.98 | 9.18 | 12 | 285406 | 568 | 70642458 |
Arterial spasm | 9.96 | 9.18 | 7 | 285411 | 163 | 70642863 |
Withdrawal syndrome | 9.96 | 9.18 | 59 | 285359 | 24845 | 70618181 |
Pyelonephritis | 9.93 | 9.18 | 115 | 285303 | 18174 | 70624852 |
Cytomegalovirus viraemia | 9.93 | 9.18 | 20 | 285398 | 11665 | 70631361 |
Illness | 9.91 | 9.18 | 81 | 285337 | 31710 | 70611316 |
Enterocolitis | 9.90 | 9.18 | 88 | 285330 | 12978 | 70630048 |
Prostate cancer | 9.90 | 9.18 | 79 | 285339 | 31084 | 70611942 |
Intervertebral discitis | 9.89 | 9.18 | 38 | 285380 | 4123 | 70638903 |
Therapeutic embolisation | 9.88 | 9.18 | 11 | 285407 | 479 | 70642547 |
Herpes simplex test positive | 9.86 | 9.18 | 10 | 285408 | 391 | 70642635 |
Vulvovaginal inflammation | 9.84 | 9.18 | 11 | 285407 | 481 | 70642545 |
Neurosis | 9.83 | 9.18 | 10 | 285408 | 392 | 70642634 |
Hepatobiliary scan abnormal | 9.80 | 9.18 | 5 | 285413 | 63 | 70642963 |
Muscle swelling | 9.77 | 9.18 | 14 | 285404 | 788 | 70642238 |
Eosinophilic oesophagitis | 9.74 | 9.18 | 11 | 285407 | 487 | 70642539 |
Unevaluable event | 9.73 | 9.18 | 149 | 285269 | 51914 | 70591112 |
Intentional self-injury | 9.71 | 9.18 | 81 | 285337 | 31569 | 70611457 |
Impaired quality of life | 9.68 | 9.18 | 13 | 285405 | 8903 | 70634123 |
Change in seizure presentation | 9.67 | 9.18 | 9 | 285409 | 316 | 70642710 |
Zinc deficiency | 9.66 | 9.18 | 5 | 285413 | 65 | 70642961 |
Faecal vomiting | 9.63 | 9.18 | 16 | 285402 | 1025 | 70642001 |
Tarsal tunnel syndrome | 9.61 | 9.18 | 11 | 285407 | 494 | 70642532 |
False negative investigation result | 9.59 | 9.18 | 8 | 285410 | 242 | 70642784 |
Hepatitis fulminant | 9.57 | 9.18 | 52 | 285366 | 6529 | 70636497 |
Malaise | 9.54 | 9.18 | 1927 | 283491 | 431005 | 70212021 |
Brain contusion | 9.53 | 9.18 | 18 | 285400 | 1276 | 70641750 |
Carbohydrate antigen 19-9 increased | 9.53 | 9.18 | 10 | 285408 | 407 | 70642619 |
Hyperammonaemic encephalopathy | 9.52 | 9.18 | 3 | 285415 | 4440 | 70638586 |
Multiple sclerosis relapse | 9.51 | 9.18 | 119 | 285299 | 42898 | 70600128 |
Purpura senile | 9.50 | 9.18 | 11 | 285407 | 500 | 70642526 |
Acute sinusitis | 9.49 | 9.18 | 38 | 285380 | 4203 | 70638823 |
Circulatory collapse | 9.48 | 9.18 | 94 | 285324 | 35380 | 70607646 |
Cytomegalovirus infection reactivation | 9.47 | 9.18 | 8 | 285410 | 6773 | 70636253 |
Eosinophilic pneumonia | 9.45 | 9.18 | 42 | 285376 | 4863 | 70638163 |
Mesenteric artery stenosis | 9.44 | 9.18 | 3 | 285415 | 9 | 70643017 |
Tongue pruritus | 9.43 | 9.18 | 11 | 285407 | 504 | 70642522 |
Aspartate aminotransferase increased | 9.41 | 9.18 | 612 | 284806 | 126366 | 70516660 |
Grip strength decreased | 9.38 | 9.18 | 32 | 285386 | 15653 | 70627373 |
Altered state of consciousness | 9.37 | 9.18 | 219 | 285199 | 39803 | 70603223 |
Hyperbilirubinaemia | 9.34 | 9.18 | 135 | 285283 | 22433 | 70620593 |
Tongue disorder | 9.34 | 9.18 | 25 | 285393 | 13202 | 70629824 |
Abnormal behaviour | 9.27 | 9.18 | 92 | 285326 | 34617 | 70608409 |
Oesophageal ulcer | 9.24 | 9.18 | 51 | 285367 | 6443 | 70636583 |
Lordosis | 9.23 | 9.18 | 9 | 285409 | 335 | 70642691 |
Tricuspid valve incompetence | 9.22 | 9.18 | 111 | 285307 | 17706 | 70625320 |
Endophthalmitis | 9.21 | 9.18 | 7 | 285411 | 6248 | 70636778 |
Arteriovenous fistula site haematoma | 9.21 | 9.18 | 4 | 285414 | 34 | 70642992 |
Rhonchi | 9.20 | 9.18 | 34 | 285384 | 3621 | 70639405 |
None
Source | Code | Description |
---|---|---|
ATC | A02BC05 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Proton pump inhibitors |
ATC | A02BD06 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | M01AE52 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives |
FDA MoA | N0000000147 | Proton Pump Inhibitors |
FDA EPC | N0000175525 | Proton Pump Inhibitor |
MeSH PA | D000897 | Anti-Ulcer Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D054328 | Proton Pump Inhibitors |
CHEBI has role | CHEBI:35623 | anticonvulsants |
CHEBI has role | CHEBI:49200 | proton pump inhibitors |
CHEBI has role | CHEBI:49201 | anti-ulcer drugs |
CHEBI has role | CHEBI:50183 | P450 inhibitors |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
FDA MoA | N0000182140 | Cytochrome P450 2C19 Inhibitors |
CHEBI has role | CHEBI:37956 | antihistamines |
CHEBI has role | CHEBI:38623 | monoamine oxidase inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Peptic ulcer | indication | 13200003 | DOID:750 |
Erosive esophagitis | indication | 40719004 | |
Zollinger-Ellison syndrome | indication | 53132006 | DOID:0050782 |
Peptic reflux disease | indication | 57643001 | |
Gastroesophageal reflux disease | indication | 235595009 | DOID:8534 |
Prevention of NSAID-Induced Gastric Ulcer | indication | ||
Osteoarthritis in Patients at High Ulcer Risk | indication | ||
Rheumatoid Arthritis in Patient at High Ulcer Risk | indication | ||
Pathological Gastric Hypersecretory Condition | indication | ||
Duodenal Ulcer due to H. Pylori | indication | ||
Maintenance of Healing Erosive Esophagitis | indication | ||
Upper gastrointestinal hemorrhage | off-label use | 37372002 | |
Hepatic failure | contraindication | 59927004 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Atrophic gastritis | contraindication | 84568007 | DOID:8929 |
Fracture of bone | contraindication | 125605004 | |
Hypomagnesemia | contraindication | 190855004 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.71 | acidic |
pKa2 | 4.44 | Basic |
pKa3 | 2.53 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 20MG BASE;375MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 8852636 | May 31, 2022 | RELIEF OF SIGNS AND SYMPTOMS OF ARTHRITIS AND RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER |
EQ 20MG BASE;375MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 8858996 | May 31, 2022 | RELIEF OF SIGNS AND SYMPTOMS OF ARTHRITIS AND RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER |
EQ 20MG BASE;375MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 9161920 | May 31, 2022 | RISK-REDUCTION OF NSAID GASTRIC ULCER IN PATIENTS REQUIRING CHRONIC NSAID TREATMENT |
EQ 20MG BASE;375MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 9198888 | May 31, 2022 | RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS REQUIRING NSAID TREATMENT |
EQ 20MG BASE;500MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 8852636 | May 31, 2022 | RELIEF OF SIGNS AND SYMPTOMS OF ARTHRITIS AND RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER |
EQ 20MG BASE;500MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 8858996 | May 31, 2022 | RELIEF OF SIGNS AND SYMPTOMS OF ARTHRITIS AND RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER |
EQ 20MG BASE;500MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 9161920 | May 31, 2022 | RISK-REDUCTION OF NSAID GASTRIC ULCER IN PATIENTS REQUIRING CHRONIC NSAID TREATMENT |
EQ 20MG BASE;500MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 9198888 | May 31, 2022 | RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS REQUIRING NSAID TREATMENT |
EQ 20MG BASE;375MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 9393208 | Sept. 3, 2029 | RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS REQUIRING NSAID TREATMENT |
EQ 20MG BASE;500MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 9393208 | Sept. 3, 2029 | RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS REQUIRING NSAID TREATMENT |
EQ 20MG BASE;500MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 9220698 | March 10, 2031 | RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS REQUIRING NSAID TREATMENT |
EQ 20MG BASE;375MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 8945621 | Oct. 17, 2031 | RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCERS IN PATIENTS ALSO TAKING LOW DOSE ASPIRIN |
EQ 20MG BASE;500MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 8945621 | Oct. 17, 2031 | RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCERS IN PATIENTS ALSO TAKING LOW DOSE ASPIRIN |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Potassium-transporting ATPase | Transporter | INHIBITOR | CHEMBL | CHEMBL |
ID | Source |
---|---|
4021259 | VUID |
N0000189434 | NUI |
D01984 | KEGG_DRUG |
217087-10-0 | SECONDARY_CAS_RN |
217087-09-7 | SECONDARY_CAS_RN |
161796-78-7 | SECONDARY_CAS_RN |
4019439 | VANDF |
4021259 | VANDF |
4021260 | VANDF |
4025229 | VANDF |
4032661 | VANDF |
C0937846 | UMLSCUI |
CHEBI:50275 | CHEBI |
CHEBI:7772 | CHEBI |
1C6 | PDB_CHEM_ID |
CHEMBL1201320 | ChEMBL_ID |
DB00736 | DRUGBANK_ID |
CHEMBL2146133 | ChEMBL_ID |
CHEMBL1200470 | ChEMBL_ID |
D064098 | MESH_DESCRIPTOR_UI |
4594 | PUBCHEM_CID |
5488 | IUPHAR_LIGAND_ID |
7766 | INN_ID |
934714-36-0 | SECONDARY_CAS_RN |
N3PA6559FT | UNII |
DB00338 | DRUGBANK_ID |
1294569 | RXNORM |
19233 | MMSL |
205449 | MMSL |
211151 | MMSL |
232889 | MMSL |
29630 | MMSL |
45807 | MMSL |
5201 | MMSL |
d00325 | MMSL |
d04749 | MMSL |
003476 | NDDF |
008590 | NDDF |
008918 | NDDF |
008919 | NDDF |
015173 | NDDF |
129489006 | SNOMEDCT_US |
25673006 | SNOMEDCT_US |
317331009 | SNOMEDCT_US |
387137007 | SNOMEDCT_US |
396047003 | SNOMEDCT_US |
426956003 | SNOMEDCT_US |
725855001 | SNOMEDCT_US |
C0028978 | UMLSCUI |
CHEMBL2146140 | ChEMBL_ID |
5081 | INN_ID |
D009853 | MESH_DESCRIPTOR_UI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Esomeprazole Magnesium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-6450 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 28 sections |
Esomeprazole Magnesium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-6450 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 28 sections |
Esomeprazole Magnesium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-6451 | CAPSULE, DELAYED RELEASE | 40 mg | ORAL | ANDA | 28 sections |
Esomeprazole Magnesium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-6451 | CAPSULE, DELAYED RELEASE | 40 mg | ORAL | ANDA | 28 sections |
good sense esomeprazole magnesium | HUMAN OTC DRUG LABEL | 1 | 0113-0651 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 15 sections |
basic care esomeprazole magnesium | HUMAN OTC DRUG LABEL | 1 | 0113-0732 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 15 sections |
Good Sense Esomeprazole Magnesium | HUMAN OTC DRUG LABEL | 1 | 0113-0898 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 15 sections |
Esomeprazole magnesium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-0382 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | NDA authorized generic | 28 sections |
Esomeprazole magnesium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-0384 | CAPSULE, DELAYED RELEASE | 40 mg | ORAL | NDA authorized generic | 28 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4010 | GRANULE, DELAYED RELEASE | 10 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4010 | GRANULE, DELAYED RELEASE | 10 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4010 | GRANULE, DELAYED RELEASE | 10 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4020 | GRANULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4020 | GRANULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4020 | GRANULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4025 | GRANULE, DELAYED RELEASE | 2.50 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4025 | GRANULE, DELAYED RELEASE | 2.50 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4025 | GRANULE, DELAYED RELEASE | 2.50 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4040 | GRANULE, DELAYED RELEASE | 40 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4040 | GRANULE, DELAYED RELEASE | 40 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4040 | GRANULE, DELAYED RELEASE | 40 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4050 | GRANULE, DELAYED RELEASE | 5 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4050 | GRANULE, DELAYED RELEASE | 5 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4050 | GRANULE, DELAYED RELEASE | 5 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-5020 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-5020 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-5020 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-5040 | CAPSULE, DELAYED RELEASE | 40 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-5040 | CAPSULE, DELAYED RELEASE | 40 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-5040 | CAPSULE, DELAYED RELEASE | 40 mg | ORAL | NDA | 27 sections |