Stem definition | Drug id | CAS RN |
---|---|---|
antiulcer, benzimidazole derivatives | 1055 | 119141-88-7 |
Dose | Unit | Route |
---|---|---|
30 | mg | O |
30 | mg | P |
0.50 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 5.79 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 53 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.20 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.85 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.03 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 0.83 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 20, 2001 | FDA | ASTRAZENECA PHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Chronic kidney disease | 825.31 | 9.38 | 916 | 207677 | 38855 | 50357676 |
Pemphigus | 435.56 | 9.38 | 13 | 208580 | 120153 | 50276378 |
Drug ineffective | 426.19 | 9.38 | 1839 | 206754 | 817494 | 49579037 |
Maternal exposure during pregnancy | 338.41 | 9.38 | 118 | 208475 | 159660 | 50236871 |
Glossodynia | 323.29 | 9.38 | 46 | 208547 | 115523 | 50281008 |
Renal injury | 321.62 | 9.38 | 274 | 208319 | 8337 | 50388194 |
Hand deformity | 312.73 | 9.38 | 27 | 208566 | 100172 | 50296359 |
Systemic lupus erythematosus | 300.97 | 9.38 | 102 | 208491 | 140520 | 50256011 |
Synovitis | 288.36 | 9.38 | 77 | 208516 | 123788 | 50272743 |
End stage renal disease | 259.32 | 9.38 | 204 | 208389 | 5533 | 50390998 |
Completed suicide | 256.74 | 9.38 | 111 | 208482 | 131778 | 50264753 |
Contraindicated product administered | 243.39 | 9.38 | 157 | 208436 | 148801 | 50247730 |
Acute kidney injury | 242.68 | 9.38 | 1690 | 206903 | 226368 | 50170163 |
Anti-cyclic citrullinated peptide antibody positive | 240.89 | 9.38 | 12 | 208581 | 70575 | 50325956 |
Alopecia | 228.58 | 9.38 | 413 | 208180 | 244634 | 50151897 |
Wound | 219.03 | 9.38 | 81 | 208512 | 105713 | 50290818 |
Pericarditis | 209.41 | 9.38 | 36 | 208557 | 78653 | 50317878 |
Off label use | 202.52 | 9.38 | 1139 | 207454 | 473287 | 49923244 |
Drug intolerance | 182.10 | 9.38 | 395 | 208198 | 218709 | 50177822 |
Hepatocellular injury | 180.41 | 9.38 | 357 | 208236 | 25590 | 50370941 |
Arthropathy | 178.95 | 9.38 | 233 | 208360 | 157673 | 50238858 |
Rheumatoid factor positive | 174.96 | 9.38 | 7 | 208586 | 49852 | 50346679 |
Cholestasis | 172.42 | 9.38 | 346 | 208247 | 25055 | 50371476 |
Infusion related reaction | 158.67 | 9.38 | 285 | 208308 | 169272 | 50227259 |
Carotid artery thrombosis | 157.28 | 9.38 | 90 | 208503 | 1409 | 50395122 |
Duodenal ulcer perforation | 154.83 | 9.38 | 8 | 208585 | 45603 | 50350928 |
Neurologic neglect syndrome | 154.21 | 9.38 | 88 | 208505 | 1370 | 50395161 |
Cholecystitis chronic | 152.94 | 9.38 | 194 | 208399 | 9475 | 50387056 |
Toxicity to various agents | 150.68 | 9.38 | 416 | 208177 | 212083 | 50184448 |
Treatment failure | 145.97 | 9.38 | 213 | 208380 | 137424 | 50259107 |
Adjustment disorder | 142.23 | 9.38 | 94 | 208499 | 1925 | 50394606 |
Joint swelling | 141.91 | 9.38 | 526 | 208067 | 244760 | 50151771 |
Interstitial lung disease | 141.77 | 9.38 | 512 | 208081 | 52664 | 50343867 |
Exposure during pregnancy | 139.72 | 9.38 | 176 | 208417 | 120839 | 50275692 |
Hyponatraemia | 138.10 | 9.38 | 770 | 207823 | 95369 | 50301162 |
Swelling | 132.37 | 9.38 | 407 | 208186 | 200465 | 50196066 |
Discomfort | 128.93 | 9.38 | 154 | 208439 | 108226 | 50288305 |
Death | 120.39 | 9.38 | 816 | 207777 | 324563 | 50071968 |
Therapeutic product effect decreased | 118.20 | 9.38 | 239 | 208354 | 135811 | 50260720 |
Hepatic enzyme increased | 117.95 | 9.38 | 243 | 208350 | 137137 | 50259394 |
Renal failure | 117.16 | 9.38 | 797 | 207796 | 105836 | 50290695 |
Personality disorder | 115.39 | 9.38 | 114 | 208479 | 4210 | 50392321 |
Helicobacter infection | 111.69 | 9.38 | 33 | 208560 | 49669 | 50346862 |
Biliary dyskinesia | 111.65 | 9.38 | 89 | 208504 | 2461 | 50394070 |
Muscle injury | 110.47 | 9.38 | 12 | 208581 | 37099 | 50359432 |
Peripheral swelling | 109.87 | 9.38 | 456 | 208137 | 205480 | 50191051 |
Folliculitis | 108.73 | 9.38 | 16 | 208577 | 39209 | 50357322 |
Product use issue | 107.85 | 9.38 | 290 | 208303 | 149185 | 50247346 |
Fatigue | 100.44 | 9.38 | 2190 | 206403 | 705411 | 49691120 |
Hemiplegia | 99.60 | 9.38 | 137 | 208456 | 7244 | 50389287 |
Product use in unapproved indication | 95.11 | 9.38 | 210 | 208383 | 115609 | 50280922 |
Gastrooesophageal reflux disease | 92.28 | 9.38 | 585 | 208008 | 75843 | 50320688 |
Abdominal discomfort | 91.64 | 9.38 | 569 | 208024 | 231072 | 50165459 |
Agranulocytosis | 88.34 | 9.38 | 240 | 208353 | 21181 | 50375350 |
Tubulointerstitial nephritis | 84.50 | 9.38 | 191 | 208402 | 15020 | 50381511 |
Hypertensive nephropathy | 83.98 | 9.38 | 41 | 208552 | 455 | 50396076 |
Dysphagia | 81.34 | 9.38 | 573 | 208020 | 76945 | 50319586 |
Sensitisation | 75.28 | 9.38 | 58 | 208535 | 1524 | 50395007 |
Eosinophilia | 74.94 | 9.38 | 207 | 208386 | 18445 | 50378086 |
Inappropriate antidiuretic hormone secretion | 74.09 | 9.38 | 166 | 208427 | 12977 | 50383554 |
Intentional product use issue | 73.04 | 9.38 | 128 | 208465 | 76790 | 50319741 |
Toxic skin eruption | 71.31 | 9.38 | 149 | 208444 | 11102 | 50385429 |
Hepatic cytolysis | 69.47 | 9.38 | 122 | 208471 | 7981 | 50388550 |
Motor dysfunction | 68.96 | 9.38 | 121 | 208472 | 7910 | 50388621 |
Rash maculo-papular | 68.86 | 9.38 | 254 | 208339 | 26387 | 50370144 |
Hypomagnesaemia | 66.90 | 9.38 | 229 | 208364 | 22927 | 50373604 |
Coordination abnormal | 66.50 | 9.38 | 147 | 208446 | 11387 | 50385144 |
Sleep disorder due to general medical condition, insomnia type | 65.17 | 9.38 | 24 | 208569 | 31423 | 50365108 |
Device expulsion | 65 | 9.38 | 19 | 208574 | 28803 | 50367728 |
Affect lability | 63.98 | 9.38 | 125 | 208468 | 8873 | 50387658 |
Abdominal pain upper | 62.22 | 9.38 | 962 | 207631 | 158347 | 50238184 |
Lower respiratory tract infection | 58.38 | 9.38 | 199 | 208394 | 95002 | 50301529 |
Polycystic ovaries | 58.11 | 9.38 | 61 | 208532 | 2423 | 50394108 |
Blister | 57.67 | 9.38 | 171 | 208422 | 85247 | 50311284 |
Gastritis | 56.86 | 9.38 | 278 | 208315 | 32705 | 50363826 |
Gastric polyps | 56.50 | 9.38 | 62 | 208531 | 2592 | 50393939 |
Drug reaction with eosinophilia and systemic symptoms | 55.92 | 9.38 | 249 | 208344 | 28175 | 50368356 |
Hypocalcaemia | 55.88 | 9.38 | 239 | 208354 | 26577 | 50369954 |
Hypersensitivity | 55.40 | 9.38 | 593 | 208000 | 214568 | 50181963 |
Pain | 55.26 | 9.38 | 1894 | 206699 | 577009 | 49819522 |
Ejection fraction | 54.94 | 9.38 | 43 | 208550 | 1157 | 50395374 |
Bronchial neoplasm | 53.64 | 9.38 | 29 | 208564 | 404 | 50396127 |
Acute generalised exanthematous pustulosis | 52.76 | 9.38 | 115 | 208478 | 8823 | 50387708 |
Pleural fibrosis | 52.10 | 9.38 | 67 | 208526 | 3317 | 50393214 |
Systemic lupus erythematosus rash | 51.98 | 9.38 | 49 | 208544 | 1706 | 50394825 |
Hiatus hernia | 51.76 | 9.38 | 180 | 208413 | 18164 | 50378367 |
C-reactive protein abnormal | 51.58 | 9.38 | 25 | 208568 | 27784 | 50368747 |
Epigastric discomfort | 51.12 | 9.38 | 89 | 208504 | 5781 | 50390750 |
Rash | 51.08 | 9.38 | 1393 | 207200 | 436078 | 49960453 |
Ill-defined disorder | 50.93 | 9.38 | 92 | 208501 | 54562 | 50341969 |
Sensory loss | 50.83 | 9.38 | 104 | 208489 | 7634 | 50388897 |
Gallbladder injury | 50.01 | 9.38 | 42 | 208551 | 1252 | 50395279 |
Rhinitis allergic | 49.96 | 9.38 | 99 | 208494 | 7101 | 50389430 |
Presbyacusis | 49.22 | 9.38 | 59 | 208534 | 2717 | 50393814 |
Abortion spontaneous | 48.96 | 9.38 | 60 | 208533 | 41712 | 50354819 |
Gallbladder disorder | 47.86 | 9.38 | 165 | 208428 | 16577 | 50379954 |
Pleural thickening | 47.34 | 9.38 | 56 | 208537 | 2543 | 50393988 |
Pregnancy | 47.13 | 9.38 | 32 | 208561 | 29545 | 50366986 |
Condition aggravated | 47.02 | 9.38 | 902 | 207691 | 296156 | 50100375 |
Intentional overdose | 46.77 | 9.38 | 119 | 208474 | 62385 | 50334146 |
Blood magnesium increased | 45.88 | 9.38 | 58 | 208535 | 2822 | 50393709 |
Nephrectomy | 45.04 | 9.38 | 33 | 208560 | 802 | 50395729 |
Nasopharyngitis | 44.84 | 9.38 | 544 | 208049 | 192383 | 50204148 |
Rebound acid hypersecretion | 44.69 | 9.38 | 23 | 208570 | 288 | 50396243 |
Nephrogenic anaemia | 43.74 | 9.38 | 44 | 208549 | 1661 | 50394870 |
Nephropathy | 43.57 | 9.38 | 78 | 208515 | 5180 | 50391351 |
Hemiparesis | 42.79 | 9.38 | 180 | 208413 | 19868 | 50376663 |
Diabetic nephropathy | 42.78 | 9.38 | 39 | 208554 | 1300 | 50395231 |
Nasal turbinate hypertrophy | 41.96 | 9.38 | 29 | 208564 | 641 | 50395890 |
Osteosclerosis | 41.82 | 9.38 | 61 | 208532 | 3406 | 50393125 |
Drug abuse | 41.71 | 9.38 | 118 | 208475 | 59728 | 50336803 |
Loss of employment | 40.82 | 9.38 | 41 | 208552 | 1545 | 50394986 |
Irritable bowel syndrome | 40.80 | 9.38 | 95 | 208498 | 51346 | 50345185 |
Anxiety | 40.73 | 9.38 | 989 | 207604 | 176617 | 50219914 |
Deafness neurosensory | 40.19 | 9.38 | 69 | 208524 | 4432 | 50392099 |
Lung disorder | 40.09 | 9.38 | 319 | 208274 | 44480 | 50352051 |
Bronchial disorder | 39.93 | 9.38 | 35 | 208558 | 1107 | 50395424 |
Eating disorder | 39.89 | 9.38 | 147 | 208446 | 15262 | 50381269 |
Knee arthroplasty | 39.42 | 9.38 | 54 | 208539 | 35792 | 50360739 |
Gamma-glutamyltransferase increased | 39.04 | 9.38 | 232 | 208361 | 29391 | 50367140 |
Prescription form tampering | 38.94 | 9.38 | 26 | 208567 | 542 | 50395989 |
Bronchial haemorrhage | 38.56 | 9.38 | 25 | 208568 | 495 | 50396036 |
Aphasia | 38.10 | 9.38 | 224 | 208369 | 28270 | 50368261 |
Psoriatic arthropathy | 37.99 | 9.38 | 86 | 208507 | 46946 | 50349585 |
Hip arthroplasty | 37.49 | 9.38 | 42 | 208551 | 30387 | 50366144 |
Injection site erythema | 36.82 | 9.38 | 171 | 208422 | 74765 | 50321766 |
Live birth | 36.66 | 9.38 | 11 | 208582 | 16397 | 50380134 |
Anaemia | 36.17 | 9.38 | 1326 | 207267 | 251130 | 50145401 |
Cholelithiasis | 35.98 | 9.38 | 274 | 208319 | 37699 | 50358832 |
Premature delivery | 35.87 | 9.38 | 27 | 208566 | 23636 | 50372895 |
Angina pectoris | 35.74 | 9.38 | 207 | 208386 | 25981 | 50370550 |
Axonal neuropathy | 35.73 | 9.38 | 30 | 208563 | 894 | 50395637 |
Pancreatitis | 34.68 | 9.38 | 297 | 208296 | 42317 | 50354214 |
Dermatitis bullous | 34.33 | 9.38 | 85 | 208508 | 7088 | 50389443 |
Cholecystitis | 33.97 | 9.38 | 130 | 208463 | 13741 | 50382790 |
Asthma | 33.90 | 9.38 | 537 | 208056 | 88800 | 50307731 |
Sleep apnoea syndrome | 33.45 | 9.38 | 190 | 208403 | 23678 | 50372853 |
COVID-19 | 33.26 | 9.38 | 91 | 208502 | 46571 | 50349960 |
Hypokalaemia | 33.04 | 9.38 | 528 | 208065 | 87464 | 50309067 |
Drug resistance | 32.38 | 9.38 | 19 | 208574 | 18970 | 50377561 |
Vascular purpura | 32.38 | 9.38 | 32 | 208561 | 1182 | 50395349 |
Drug hypersensitivity | 31.67 | 9.38 | 790 | 207803 | 250220 | 50146311 |
Arterial occlusive disease | 30.85 | 9.38 | 64 | 208529 | 4744 | 50391787 |
Caesarean section | 30.66 | 9.38 | 13 | 208580 | 15626 | 50380905 |
Asthenia | 30.65 | 9.38 | 1608 | 206985 | 317434 | 50079097 |
Gastric antral vascular ectasia | 30.48 | 9.38 | 22 | 208571 | 522 | 50396009 |
Abdominal pain | 30.33 | 9.38 | 1226 | 207367 | 235002 | 50161529 |
Red blood cell sedimentation rate abnormal | 29.84 | 9.38 | 15 | 208578 | 16328 | 50380203 |
Tenosynovitis stenosans | 29.59 | 9.38 | 41 | 208552 | 2183 | 50394348 |
Urate nephropathy | 29.28 | 9.38 | 13 | 208580 | 114 | 50396417 |
Endometrial ablation | 29.28 | 9.38 | 26 | 208567 | 837 | 50395694 |
Injection site pain | 28.94 | 9.38 | 305 | 208288 | 110719 | 50285812 |
Dry mouth | 28.71 | 9.38 | 356 | 208237 | 55822 | 50340709 |
Foetal exposure during pregnancy | 28.33 | 9.38 | 43 | 208550 | 27316 | 50369215 |
Mobility decreased | 28.23 | 9.38 | 203 | 208390 | 79745 | 50316786 |
Cholestatic liver injury | 28.00 | 9.38 | 38 | 208555 | 1983 | 50394548 |
Dry eye | 27.88 | 9.38 | 227 | 208366 | 31868 | 50364663 |
Fall | 27.29 | 9.38 | 1663 | 206930 | 333269 | 50063262 |
Impaired healing | 27.23 | 9.38 | 172 | 208421 | 69614 | 50326917 |
Iron deficiency anaemia | 26.97 | 9.38 | 139 | 208454 | 16695 | 50379836 |
Cell death | 26.76 | 9.38 | 39 | 208554 | 2176 | 50394355 |
No adverse event | 26.63 | 9.38 | 62 | 208531 | 33516 | 50363015 |
Therapy non-responder | 26.52 | 9.38 | 114 | 208479 | 50908 | 50345623 |
Bone cyst | 26.46 | 9.38 | 37 | 208556 | 1987 | 50394544 |
Infection | 26.46 | 9.38 | 528 | 208065 | 172426 | 50224105 |
Erythema dyschromicum perstans | 26.32 | 9.38 | 10 | 208583 | 56 | 50396475 |
Nephritis allergic | 26.26 | 9.38 | 13 | 208580 | 149 | 50396382 |
Rhabdomyolysis | 26.20 | 9.38 | 261 | 208332 | 38766 | 50357765 |
Accidental exposure to product | 26.10 | 9.38 | 34 | 208559 | 23023 | 50373508 |
Impaired work ability | 25.71 | 9.38 | 118 | 208475 | 13522 | 50383009 |
Gastric disorder | 25.67 | 9.38 | 209 | 208384 | 29339 | 50367192 |
Adverse drug reaction | 25.39 | 9.38 | 129 | 208464 | 55093 | 50341438 |
Musculoskeletal stiffness | 25.21 | 9.38 | 375 | 208218 | 128106 | 50268425 |
Pancreatitis acute | 24.94 | 9.38 | 176 | 208417 | 23636 | 50372895 |
Hypothyroidism | 24.77 | 9.38 | 232 | 208361 | 33893 | 50362638 |
Angina bullosa haemorrhagica | 24.67 | 9.38 | 12 | 208581 | 132 | 50396399 |
Cross sensitivity reaction | 24.27 | 9.38 | 35 | 208558 | 1934 | 50394597 |
Cutaneous lupus erythematosus | 24.02 | 9.38 | 39 | 208554 | 2392 | 50394139 |
Chest pain | 23.85 | 9.38 | 923 | 207670 | 175959 | 50220572 |
Anal abscess | 23.78 | 9.38 | 50 | 208543 | 3741 | 50392790 |
Dysarthria | 23.61 | 9.38 | 247 | 208346 | 37156 | 50359375 |
Phlebitis | 23.49 | 9.38 | 64 | 208529 | 5656 | 50390875 |
Lip oedema | 23.49 | 9.38 | 45 | 208548 | 3148 | 50393383 |
Therapeutic response decreased | 23.06 | 9.38 | 108 | 208485 | 47123 | 50349408 |
Gallbladder polyp | 23.03 | 9.38 | 21 | 208572 | 700 | 50395831 |
Occupational asthma | 23.02 | 9.38 | 11 | 208582 | 116 | 50396415 |
Synovial fluid analysis | 23.00 | 9.38 | 31 | 208562 | 1607 | 50394924 |
Nausea | 22.62 | 9.38 | 3275 | 205318 | 702123 | 49694408 |
Malnutrition | 22.61 | 9.38 | 111 | 208482 | 13078 | 50383453 |
Herpes simplex test positive | 22.54 | 9.38 | 11 | 208582 | 122 | 50396409 |
Rheumatoid arthritis | 22.26 | 9.38 | 650 | 207943 | 201900 | 50194631 |
Muscle haemorrhage | 22.14 | 9.38 | 42 | 208551 | 2916 | 50393615 |
Poisoning | 21.82 | 9.38 | 12 | 208581 | 12417 | 50384114 |
Arthralgia | 21.80 | 9.38 | 1536 | 207057 | 437166 | 49959365 |
Hypergastrinaemia | 21.74 | 9.38 | 10 | 208583 | 96 | 50396435 |
Hypocapnia | 21.61 | 9.38 | 15 | 208578 | 334 | 50396197 |
Anaemia macrocytic | 21.25 | 9.38 | 38 | 208555 | 2521 | 50394010 |
Cyst | 21.20 | 9.38 | 103 | 208490 | 12084 | 50384447 |
Drug interaction | 20.96 | 9.38 | 1015 | 207578 | 198606 | 50197925 |
Cerebral haematoma | 20.90 | 9.38 | 43 | 208550 | 3168 | 50393363 |
Schizophreniform disorder | 20.88 | 9.38 | 9 | 208584 | 73 | 50396458 |
Drug tolerance decreased | 20.72 | 9.38 | 6 | 208587 | 9154 | 50387377 |
Renal impairment | 20.67 | 9.38 | 432 | 208161 | 75229 | 50321302 |
Palpitations | 20.66 | 9.38 | 523 | 208070 | 93983 | 50302548 |
Therapy interrupted | 20.55 | 9.38 | 32 | 208561 | 20120 | 50376411 |
Febrile bone marrow aplasia | 20.54 | 9.38 | 65 | 208528 | 6246 | 50390285 |
Haematoma | 20.46 | 9.38 | 204 | 208389 | 30306 | 50366225 |
Neutropenic sepsis | 20.36 | 9.38 | 17 | 208576 | 14130 | 50382401 |
Gallbladder hypofunction | 20.21 | 9.38 | 17 | 208576 | 508 | 50396023 |
Stomatitis | 20.15 | 9.38 | 295 | 208298 | 101049 | 50295482 |
Bursitis | 20.01 | 9.38 | 158 | 208435 | 21977 | 50374554 |
Neurotoxicity | 19.68 | 9.38 | 19 | 208574 | 14721 | 50381810 |
Cholecystectomy | 19.44 | 9.38 | 83 | 208510 | 9220 | 50387311 |
Crepitations | 19.29 | 9.38 | 63 | 208530 | 6156 | 50390375 |
Supraventricular extrasystoles | 19.16 | 9.38 | 47 | 208546 | 3897 | 50392634 |
Chronic cutaneous lupus erythematosus | 18.84 | 9.38 | 10 | 208583 | 134 | 50396397 |
Loss of personal independence in daily activities | 18.83 | 9.38 | 191 | 208402 | 69859 | 50326672 |
Flatulence | 18.81 | 9.38 | 195 | 208398 | 29263 | 50367268 |
Tetany | 18.80 | 9.38 | 28 | 208565 | 1593 | 50394938 |
Mixed liver injury | 18.79 | 9.38 | 43 | 208550 | 3408 | 50393123 |
Mesenteric panniculitis | 18.66 | 9.38 | 9 | 208584 | 97 | 50396434 |
Dyspepsia | 18.61 | 9.38 | 418 | 208175 | 73679 | 50322852 |
Muscle spasticity | 18.58 | 9.38 | 128 | 208465 | 17056 | 50379475 |
Myelosuppression | 18.54 | 9.38 | 17 | 208576 | 13500 | 50383031 |
Nephritic syndrome | 18.53 | 9.38 | 11 | 208582 | 185 | 50396346 |
Scleritis | 18.46 | 9.38 | 41 | 208552 | 3186 | 50393345 |
Carpal tunnel syndrome | 18.36 | 9.38 | 126 | 208467 | 16767 | 50379764 |
Haematotoxicity | 18.18 | 9.38 | 5 | 208588 | 7890 | 50388641 |
Hepatitis | 18.13 | 9.38 | 204 | 208389 | 31249 | 50365282 |
Hepatitis cholestatic | 18.11 | 9.38 | 61 | 208532 | 6056 | 50390475 |
Gastrointestinal motility disorder | 18.07 | 9.38 | 50 | 208543 | 4459 | 50392072 |
Small cell carcinoma | 18.03 | 9.38 | 10 | 208583 | 147 | 50396384 |
Injection site bruising | 18.00 | 9.38 | 84 | 208509 | 36684 | 50359847 |
Blood alkaline phosphatase increased | 17.98 | 9.38 | 235 | 208358 | 37291 | 50359240 |
Muscle swelling | 17.91 | 9.38 | 14 | 208579 | 376 | 50396155 |
Injection site swelling | 17.86 | 9.38 | 100 | 208493 | 41673 | 50354858 |
Rectosigmoid cancer | 17.85 | 9.38 | 10 | 208583 | 150 | 50396381 |
Oesophageal dilatation | 17.60 | 9.38 | 13 | 208580 | 320 | 50396211 |
Bradypnoea | 17.52 | 9.38 | 39 | 208554 | 3035 | 50393496 |
Liver function test increased | 17.46 | 9.38 | 51 | 208542 | 25555 | 50370976 |
Muscular weakness | 17.42 | 9.38 | 514 | 208079 | 94499 | 50302032 |
Pneumobilia | 17.40 | 9.38 | 9 | 208584 | 114 | 50396417 |
Congenital osteodystrophy | 17.22 | 9.38 | 6 | 208587 | 25 | 50396506 |
Hyperchlorhydria | 17.16 | 9.38 | 26 | 208567 | 1502 | 50395029 |
Injection site pruritus | 17.14 | 9.38 | 97 | 208496 | 40314 | 50356217 |
Face oedema | 17.05 | 9.38 | 129 | 208464 | 17710 | 50378821 |
Bone erosion | 16.88 | 9.38 | 14 | 208579 | 11673 | 50384858 |
Electric shock | 16.85 | 9.38 | 21 | 208572 | 1007 | 50395524 |
Osteopenia | 16.80 | 9.38 | 124 | 208469 | 16894 | 50379637 |
Device dependence | 16.71 | 9.38 | 5 | 208588 | 11 | 50396520 |
Bile duct stone | 16.69 | 9.38 | 40 | 208553 | 3267 | 50393264 |
Hepatotoxicity | 16.62 | 9.38 | 57 | 208536 | 27169 | 50369362 |
Livedo reticularis | 16.46 | 9.38 | 31 | 208562 | 2141 | 50394390 |
Pathological fracture | 16.41 | 9.38 | 69 | 208524 | 7613 | 50388918 |
Early satiety | 16.37 | 9.38 | 18 | 208575 | 754 | 50395777 |
Anaemia folate deficiency | 16.30 | 9.38 | 10 | 208583 | 179 | 50396352 |
Arterial spasm | 16.11 | 9.38 | 7 | 208586 | 58 | 50396473 |
IIIrd nerve paresis | 16.06 | 9.38 | 9 | 208584 | 135 | 50396396 |
Genital infection female | 16.06 | 9.38 | 8 | 208585 | 93 | 50396438 |
Blood chromogranin A increased | 15.96 | 9.38 | 11 | 208582 | 242 | 50396289 |
Normal newborn | 15.86 | 9.38 | 4 | 208589 | 6687 | 50389844 |
International normalised ratio increased | 15.84 | 9.38 | 258 | 208335 | 42894 | 50353637 |
Eczema | 15.81 | 9.38 | 153 | 208440 | 22549 | 50373982 |
Gastrointestinal haemorrhage | 15.80 | 9.38 | 405 | 208188 | 72916 | 50323615 |
Oesophageal polyp | 15.76 | 9.38 | 4 | 208589 | 3 | 50396528 |
Renal disorder | 15.68 | 9.38 | 178 | 208415 | 27327 | 50369204 |
Crohn's disease | 15.64 | 9.38 | 49 | 208544 | 4684 | 50391847 |
Therapy partial responder | 15.51 | 9.38 | 4 | 208589 | 6587 | 50389944 |
Escherichia pyelonephritis | 15.49 | 9.38 | 13 | 208580 | 387 | 50396144 |
Kidney infection | 15.43 | 9.38 | 131 | 208462 | 18615 | 50377916 |
Oesophagitis ulcerative | 15.42 | 9.38 | 14 | 208579 | 464 | 50396067 |
Acute hepatitis B | 15.33 | 9.38 | 12 | 208581 | 323 | 50396208 |
Muscle contractions involuntary | 15.27 | 9.38 | 28 | 208565 | 1894 | 50394637 |
Skin lesion | 15.25 | 9.38 | 173 | 208420 | 26554 | 50369977 |
Premature labour | 15.08 | 9.38 | 15 | 208578 | 11461 | 50385070 |
Sinus congestion | 15.07 | 9.38 | 104 | 208489 | 13867 | 50382664 |
Prothrombin time ratio decreased | 15.05 | 9.38 | 13 | 208580 | 403 | 50396128 |
Angina unstable | 14.93 | 9.38 | 61 | 208532 | 6645 | 50389886 |
Brucellosis | 14.92 | 9.38 | 6 | 208587 | 40 | 50396491 |
Chondrocalcinosis pyrophosphate | 14.91 | 9.38 | 20 | 208573 | 1032 | 50395499 |
Adenocarcinoma gastric | 14.88 | 9.38 | 14 | 208579 | 486 | 50396045 |
Subacute cutaneous lupus erythematosus | 14.82 | 9.38 | 30 | 208563 | 2185 | 50394346 |
Hyperthermia | 14.82 | 9.38 | 67 | 208526 | 7629 | 50388902 |
Blood potassium increased | 14.79 | 9.38 | 117 | 208476 | 16281 | 50380250 |
Keratoacanthoma | 14.78 | 9.38 | 13 | 208580 | 413 | 50396118 |
Pancreatitis chronic | 14.77 | 9.38 | 30 | 208563 | 2190 | 50394341 |
Granuloma skin | 14.75 | 9.38 | 3 | 208590 | 5815 | 50390716 |
Clinically isolated syndrome | 14.71 | 9.38 | 5 | 208588 | 19 | 50396512 |
Thymus disorder | 14.59 | 9.38 | 10 | 208583 | 218 | 50396313 |
Oedema peripheral | 14.49 | 9.38 | 793 | 207800 | 157168 | 50239363 |
Jaundice | 14.16 | 9.38 | 169 | 208424 | 26260 | 50370271 |
Renal cyst | 14.10 | 9.38 | 72 | 208521 | 8615 | 50387916 |
Adverse event | 14.08 | 9.38 | 114 | 208479 | 43649 | 50352882 |
Gangrene | 14.08 | 9.38 | 47 | 208546 | 4645 | 50391886 |
Neutropenia | 14.03 | 9.38 | 484 | 208109 | 147481 | 50249050 |
Product dose omission issue | 14.02 | 9.38 | 617 | 207976 | 183221 | 50213310 |
Haemoglobin decreased | 14.01 | 9.38 | 650 | 207943 | 126566 | 50269965 |
Calcium metabolism disorder | 13.99 | 9.38 | 8 | 208585 | 125 | 50396406 |
Purging | 13.99 | 9.38 | 6 | 208587 | 48 | 50396483 |
Hyperparathyroidism secondary | 13.81 | 9.38 | 22 | 208571 | 1328 | 50395203 |
Pre-eclampsia | 13.78 | 9.38 | 8 | 208585 | 8036 | 50388495 |
Abortion induced | 13.73 | 9.38 | 11 | 208582 | 9333 | 50387198 |
Meningitis aseptic | 13.73 | 9.38 | 43 | 208550 | 4109 | 50392422 |
Bunion operation | 13.71 | 9.38 | 20 | 208573 | 1117 | 50395414 |
Uveal melanoma | 13.62 | 9.38 | 4 | 208589 | 8 | 50396523 |
Macular degeneration | 13.60 | 9.38 | 24 | 208569 | 14364 | 50382167 |
Hepatic steatosis | 13.54 | 9.38 | 157 | 208436 | 24227 | 50372304 |
Dehydration | 13.53 | 9.38 | 763 | 207830 | 151686 | 50244845 |
Emotional distress | 13.52 | 9.38 | 179 | 208414 | 28484 | 50368047 |
Lymphangiectasia | 13.49 | 9.38 | 3 | 208590 | 0 | 50396531 |
Synovial cyst | 13.48 | 9.38 | 68 | 208525 | 8098 | 50388433 |
Protein-losing gastroenteropathy | 13.46 | 9.38 | 9 | 208584 | 188 | 50396343 |
Wrong technique in product usage process | 13.46 | 9.38 | 155 | 208438 | 55355 | 50341176 |
Ejection fraction abnormal | 13.40 | 9.38 | 17 | 208576 | 830 | 50395701 |
Photophobia | 13.31 | 9.38 | 106 | 208487 | 14781 | 50381750 |
Dermatitis exfoliative | 13.26 | 9.38 | 49 | 208544 | 5093 | 50391438 |
Vertigo | 13.20 | 9.38 | 293 | 208300 | 51539 | 50344992 |
Infusion site scar | 13.18 | 9.38 | 11 | 208582 | 325 | 50396206 |
Therapeutic response shortened | 13.17 | 9.38 | 7 | 208586 | 7382 | 50389149 |
Vitamin B12 decreased | 13.10 | 9.38 | 33 | 208560 | 2782 | 50393749 |
Musculoskeletal chest pain | 13.08 | 9.38 | 125 | 208468 | 18361 | 50378170 |
Hyponatraemic seizure | 13.06 | 9.38 | 12 | 208581 | 404 | 50396127 |
Gastrointestinal tract mucosal pigmentation | 13.06 | 9.38 | 14 | 208579 | 570 | 50395961 |
Paranasal sinus inflammation | 13.04 | 9.38 | 12 | 208581 | 405 | 50396126 |
Hypoplastic anaemia | 13.01 | 9.38 | 4 | 208589 | 10 | 50396521 |
Renal tubular disorder | 12.87 | 9.38 | 30 | 208563 | 2407 | 50394124 |
Rectal haemorrhage | 12.86 | 9.38 | 227 | 208366 | 38331 | 50358200 |
Rhonchi | 12.85 | 9.38 | 29 | 208564 | 2278 | 50394253 |
Lordosis | 12.84 | 9.38 | 10 | 208583 | 267 | 50396264 |
Melaena | 12.77 | 9.38 | 168 | 208425 | 26696 | 50369835 |
Renal haemangioma | 12.74 | 9.38 | 5 | 208588 | 31 | 50396500 |
Transient ischaemic attack | 12.73 | 9.38 | 195 | 208398 | 32015 | 50364516 |
Vulvovaginal inflammation | 12.71 | 9.38 | 14 | 208579 | 588 | 50395943 |
Sedation | 12.69 | 9.38 | 74 | 208519 | 30536 | 50365995 |
Drug ineffective for unapproved indication | 12.69 | 9.38 | 45 | 208548 | 21236 | 50375295 |
Gastric cancer | 12.63 | 9.38 | 34 | 208559 | 2984 | 50393547 |
Campylobacter colitis | 12.60 | 9.38 | 5 | 208588 | 32 | 50396499 |
Haemorrhoids | 12.58 | 9.38 | 127 | 208466 | 18926 | 50377605 |
Medication error | 12.58 | 9.38 | 92 | 208501 | 36012 | 50360519 |
Device dislocation | 12.55 | 9.38 | 46 | 208547 | 21500 | 50375031 |
Hyperlipasaemia | 12.54 | 9.38 | 13 | 208580 | 509 | 50396022 |
Disease progression | 12.53 | 9.38 | 300 | 208293 | 95566 | 50300965 |
Panniculitis | 12.51 | 9.38 | 10 | 208583 | 8493 | 50388038 |
Resorption bone increased | 12.50 | 9.38 | 18 | 208575 | 993 | 50395538 |
Monoclonal gammopathy | 12.50 | 9.38 | 14 | 208579 | 599 | 50395932 |
Intestinal infarction | 12.49 | 9.38 | 18 | 208575 | 994 | 50395537 |
Intentional self-injury | 12.40 | 9.38 | 51 | 208542 | 23061 | 50373470 |
Bladder sphincter atony | 12.40 | 9.38 | 8 | 208585 | 157 | 50396374 |
Cerebellar haematoma | 12.39 | 9.38 | 11 | 208582 | 354 | 50396177 |
Body temperature increased | 12.35 | 9.38 | 77 | 208516 | 31264 | 50365267 |
Congenital bowing of long bones | 12.34 | 9.38 | 6 | 208587 | 66 | 50396465 |
Deformity | 12.33 | 9.38 | 65 | 208528 | 7875 | 50388656 |
Rash scarlatiniform | 12.26 | 9.38 | 7 | 208586 | 109 | 50396422 |
Hyperphosphatasaemia | 12.25 | 9.38 | 4 | 208589 | 13 | 50396518 |
Renal atrophy | 12.22 | 9.38 | 20 | 208573 | 1235 | 50395296 |
Type I hypersensitivity | 12.20 | 9.38 | 29 | 208564 | 2356 | 50394175 |
Proteinuria | 12.12 | 9.38 | 113 | 208480 | 16484 | 50380047 |
Rheumatoid nodule | 12.12 | 9.38 | 92 | 208501 | 12643 | 50383888 |
Nerve injury | 12.05 | 9.38 | 67 | 208526 | 8283 | 50388248 |
Tongue oedema | 12.00 | 9.38 | 39 | 208554 | 3800 | 50392731 |
Heat stroke | 11.95 | 9.38 | 14 | 208579 | 629 | 50395902 |
Malabsorption | 11.91 | 9.38 | 38 | 208555 | 3668 | 50392863 |
Complication of device insertion | 11.87 | 9.38 | 5 | 208588 | 6036 | 50390495 |
Colitis | 11.86 | 9.38 | 224 | 208369 | 38305 | 50358226 |
Dialysis | 11.85 | 9.38 | 73 | 208520 | 9365 | 50387166 |
Tooth infection | 11.82 | 9.38 | 99 | 208494 | 14013 | 50382518 |
Contusion | 11.82 | 9.38 | 362 | 208231 | 111821 | 50284710 |
Drug eruption | 11.80 | 9.38 | 149 | 208444 | 23457 | 50373074 |
Gastrointestinal ischaemia | 11.77 | 9.38 | 8 | 208585 | 172 | 50396359 |
Vitreous detachment | 11.65 | 9.38 | 24 | 208569 | 1770 | 50394761 |
Hypoosmolar state | 11.65 | 9.38 | 8 | 208585 | 175 | 50396356 |
Neurosis | 11.63 | 9.38 | 9 | 208584 | 238 | 50396293 |
Aeromonas infection | 11.60 | 9.38 | 6 | 208587 | 76 | 50396455 |
Respiratory tract congestion | 11.57 | 9.38 | 99 | 208494 | 14100 | 50382431 |
Dermatosis | 11.54 | 9.38 | 9 | 208584 | 241 | 50396290 |
Rectal cancer metastatic | 11.54 | 9.38 | 9 | 208584 | 241 | 50396290 |
Unintentional medical device removal | 11.51 | 9.38 | 4 | 208589 | 5431 | 50391100 |
Pleuritic pain | 11.50 | 9.38 | 55 | 208538 | 6411 | 50390120 |
Vaginal haemorrhage | 11.48 | 9.38 | 57 | 208536 | 24494 | 50372037 |
Poor personal hygiene | 11.44 | 9.38 | 10 | 208583 | 315 | 50396216 |
Diverticulum | 11.44 | 9.38 | 79 | 208514 | 10535 | 50385996 |
Gastric adenoma | 11.42 | 9.38 | 3 | 208590 | 3 | 50396528 |
Platelet adhesiveness decreased | 11.42 | 9.38 | 3 | 208590 | 3 | 50396528 |
Blood magnesium decreased | 11.41 | 9.38 | 82 | 208511 | 11078 | 50385453 |
Respiratory depression | 11.38 | 9.38 | 20 | 208573 | 11990 | 50384541 |
Hyperkalaemia | 11.37 | 9.38 | 269 | 208324 | 47820 | 50348711 |
Coronary artery occlusion | 11.36 | 9.38 | 61 | 208532 | 7442 | 50389089 |
Teeth brittle | 11.34 | 9.38 | 12 | 208581 | 481 | 50396050 |
Sinus bradycardia | 11.32 | 9.38 | 93 | 208500 | 13090 | 50383441 |
Malignant neoplasm progression | 11.32 | 9.38 | 205 | 208388 | 67919 | 50328612 |
Seizure | 11.31 | 9.38 | 385 | 208208 | 117489 | 50279042 |
Neoplasm progression | 11.30 | 9.38 | 72 | 208521 | 29085 | 50367446 |
Immunodeficiency | 11.27 | 9.38 | 28 | 208565 | 14800 | 50381731 |
Erosive oesophagitis | 11.21 | 9.38 | 22 | 208571 | 1567 | 50394964 |
Hypofibrinogenaemia | 11.21 | 9.38 | 18 | 208575 | 1094 | 50395437 |
Regurgitation | 11.19 | 9.38 | 20 | 208573 | 1326 | 50395205 |
Respiratory arrest | 11.18 | 9.38 | 75 | 208518 | 29934 | 50366597 |
Dystonia | 11.17 | 9.38 | 20 | 208573 | 11906 | 50384625 |
Hypoparathyroidism | 11.15 | 9.38 | 13 | 208580 | 581 | 50395950 |
Polyglandular autoimmune syndrome type II | 11.15 | 9.38 | 5 | 208588 | 45 | 50396486 |
Muscle enzyme increased | 11.14 | 9.38 | 7 | 208586 | 131 | 50396400 |
Thrombocytopenia | 11.13 | 9.38 | 638 | 207955 | 127035 | 50269496 |
Enterocolitis haemorrhagic | 11.08 | 9.38 | 20 | 208573 | 1337 | 50395194 |
Lumbar spinal stenosis | 11.06 | 9.38 | 40 | 208553 | 4114 | 50392417 |
Transplant rejection | 11.05 | 9.38 | 14 | 208579 | 9595 | 50386936 |
Blood thyroid stimulating hormone increased | 10.97 | 9.38 | 52 | 208541 | 6040 | 50390491 |
Acute cutaneous lupus erythematosus | 10.93 | 9.38 | 9 | 208584 | 261 | 50396270 |
Antinuclear antibody positive | 10.90 | 9.38 | 53 | 208540 | 6219 | 50390312 |
Tachycardia paroxysmal | 10.90 | 9.38 | 9 | 208584 | 262 | 50396269 |
Female sterilisation | 10.89 | 9.38 | 12 | 208581 | 504 | 50396027 |
Concussion | 10.87 | 9.38 | 61 | 208532 | 7567 | 50388964 |
Eructation | 10.86 | 9.38 | 58 | 208535 | 7063 | 50389468 |
Vulval disorder | 10.84 | 9.38 | 14 | 208579 | 696 | 50395835 |
Diverticulum oesophageal | 10.82 | 9.38 | 7 | 208586 | 138 | 50396393 |
Musculoskeletal disorder | 10.81 | 9.38 | 36 | 208557 | 17313 | 50379218 |
Atelectasis | 10.76 | 9.38 | 119 | 208474 | 18151 | 50378380 |
Fibromyalgia | 10.75 | 9.38 | 252 | 208341 | 44726 | 50351805 |
Oesophagitis | 10.74 | 9.38 | 93 | 208500 | 13290 | 50383241 |
Lipase increased | 10.69 | 9.38 | 66 | 208527 | 8475 | 50388056 |
Nikolsky's sign | 10.65 | 9.38 | 6 | 208587 | 91 | 50396440 |
Purpura senile | 10.65 | 9.38 | 12 | 208581 | 517 | 50396014 |
Purple glove syndrome | 10.56 | 9.38 | 8 | 208585 | 205 | 50396326 |
Tongue pruritus | 10.48 | 9.38 | 11 | 208582 | 437 | 50396094 |
Cholangitis | 10.47 | 9.38 | 42 | 208551 | 4537 | 50391994 |
Colitis ischaemic | 10.47 | 9.38 | 71 | 208522 | 9412 | 50387119 |
Gastric ulcer | 10.45 | 9.38 | 134 | 208459 | 21171 | 50375360 |
Eye haematoma | 10.44 | 9.38 | 4 | 208589 | 23 | 50396508 |
Maternal exposure before pregnancy | 10.43 | 9.38 | 5 | 208588 | 5592 | 50390939 |
Faeces discoloured | 10.42 | 9.38 | 107 | 208486 | 16017 | 50380514 |
Pancreatic neuroendocrine tumour | 10.42 | 9.38 | 9 | 208584 | 279 | 50396252 |
Bicytopenia | 10.41 | 9.38 | 24 | 208569 | 1912 | 50394619 |
Renal hypertension | 10.40 | 9.38 | 7 | 208586 | 148 | 50396383 |
Respiratory syncytial virus infection | 10.39 | 9.38 | 4 | 208589 | 5098 | 50391433 |
Peripheral artery thrombosis | 10.36 | 9.38 | 22 | 208571 | 1658 | 50394873 |
Abdominal adhesions | 10.33 | 9.38 | 30 | 208563 | 2750 | 50393781 |
Atrioventricular block complete | 10.33 | 9.38 | 58 | 208535 | 7197 | 50389334 |
Cardiothoracic ratio increased | 10.30 | 9.38 | 4 | 208589 | 24 | 50396507 |
Renal hypertrophy | 10.30 | 9.38 | 4 | 208589 | 24 | 50396507 |
Placental calcification | 10.30 | 9.38 | 4 | 208589 | 24 | 50396507 |
Weight increased | 10.30 | 9.38 | 705 | 207888 | 201186 | 50195345 |
Acute coronary syndrome | 10.24 | 9.38 | 70 | 208523 | 9304 | 50387227 |
Purpura | 10.23 | 9.38 | 73 | 208520 | 9838 | 50386693 |
Laboratory test abnormal | 10.22 | 9.38 | 55 | 208538 | 23153 | 50373378 |
Endometrial cancer stage III | 10.22 | 9.38 | 3 | 208590 | 6 | 50396525 |
Face and mouth X-ray abnormal | 10.22 | 9.38 | 3 | 208590 | 6 | 50396525 |
Diverticulum intestinal | 10.22 | 9.38 | 50 | 208543 | 5883 | 50390648 |
Carnitine deficiency | 10.20 | 9.38 | 7 | 208586 | 153 | 50396378 |
Device issue | 10.15 | 9.38 | 45 | 208548 | 19927 | 50376604 |
Neuroleptic malignant syndrome | 10.13 | 9.38 | 19 | 208574 | 11111 | 50385420 |
Hepatobiliary scan abnormal | 10.12 | 9.38 | 5 | 208588 | 57 | 50396474 |
Dilatation atrial | 10.09 | 9.38 | 23 | 208570 | 1818 | 50394713 |
Lichen planus | 10.06 | 9.38 | 24 | 208569 | 1955 | 50394576 |
Vagus nerve disorder | 10 | 9.38 | 6 | 208587 | 103 | 50396428 |
Dyslipidaemia | 9.98 | 9.38 | 50 | 208543 | 5938 | 50390593 |
Oesophageal irritation | 9.95 | 9.38 | 6 | 208587 | 104 | 50396427 |
Stent placement | 9.93 | 9.38 | 34 | 208559 | 3404 | 50393127 |
Pulmonary artery stenosis | 9.92 | 9.38 | 7 | 208586 | 160 | 50396371 |
Arterial fibrosis | 9.90 | 9.38 | 3 | 208590 | 7 | 50396524 |
Portal vein dilatation | 9.90 | 9.38 | 4 | 208589 | 27 | 50396504 |
Affective disorder | 9.90 | 9.38 | 45 | 208548 | 5136 | 50391395 |
Sleep disorder due to a general medical condition | 9.89 | 9.38 | 58 | 208535 | 7313 | 50389218 |
Unintended pregnancy | 9.87 | 9.38 | 4 | 208589 | 4942 | 50391589 |
Septic shock | 9.86 | 9.38 | 307 | 208286 | 56868 | 50339663 |
Tri-iodothyronine free decreased | 9.85 | 9.38 | 9 | 208584 | 301 | 50396230 |
Vitamin B12 deficiency | 9.84 | 9.38 | 37 | 208556 | 3879 | 50392652 |
Tonic clonic movements | 9.80 | 9.38 | 18 | 208575 | 1219 | 50395312 |
Renal infarct | 9.80 | 9.38 | 19 | 208574 | 1341 | 50395190 |
Cardiac arrest | 9.80 | 9.38 | 266 | 208327 | 83385 | 50313146 |
Oedema mouth | 9.78 | 9.38 | 26 | 208567 | 2264 | 50394267 |
Retinal artery occlusion | 9.78 | 9.38 | 20 | 208573 | 1467 | 50395064 |
Job dissatisfaction | 9.78 | 9.38 | 4 | 208589 | 28 | 50396503 |
Pyelonephritis acute | 9.78 | 9.38 | 38 | 208555 | 4045 | 50392486 |
Fungal oesophagitis | 9.72 | 9.38 | 12 | 208581 | 570 | 50395961 |
Thrombocytopenic purpura | 9.71 | 9.38 | 18 | 208575 | 1228 | 50395303 |
Therapy cessation | 9.69 | 9.38 | 65 | 208528 | 25946 | 50370585 |
Hepatic cirrhosis | 9.68 | 9.38 | 113 | 208480 | 17464 | 50379067 |
Hunger | 9.67 | 9.38 | 39 | 208554 | 4224 | 50392307 |
Giardiasis | 9.66 | 9.38 | 4 | 208589 | 29 | 50396502 |
Cardio-respiratory arrest | 9.65 | 9.38 | 160 | 208433 | 53732 | 50342799 |
Pulmonary arterial hypertension | 9.63 | 9.38 | 127 | 208466 | 20192 | 50376339 |
Coma acidotic | 9.61 | 9.38 | 6 | 208587 | 111 | 50396420 |
Dysgeusia | 9.60 | 9.38 | 219 | 208374 | 38697 | 50357834 |
Small intestinal stenosis | 9.56 | 9.38 | 11 | 208582 | 485 | 50396046 |
Renal lymphocele | 9.55 | 9.38 | 5 | 208588 | 65 | 50396466 |
Haemoconcentration | 9.55 | 9.38 | 5 | 208588 | 65 | 50396466 |
Renal tuberculosis | 9.55 | 9.38 | 4 | 208589 | 30 | 50396501 |
Hepatic cancer recurrent | 9.55 | 9.38 | 4 | 208589 | 30 | 50396501 |
Erythema multiforme | 9.54 | 9.38 | 67 | 208526 | 8983 | 50387548 |
Rhinalgia | 9.52 | 9.38 | 16 | 208577 | 1010 | 50395521 |
Burning sensation | 9.49 | 9.38 | 250 | 208343 | 45196 | 50351335 |
Vomiting | 9.46 | 9.38 | 2091 | 206502 | 458667 | 49937864 |
Atypical fracture | 9.44 | 9.38 | 12 | 208581 | 587 | 50395944 |
Language disorder | 9.43 | 9.38 | 22 | 208571 | 1766 | 50394765 |
Crystal arthropathy | 9.40 | 9.38 | 8 | 208585 | 243 | 50396288 |
Fracture nonunion | 9.39 | 9.38 | 25 | 208568 | 2179 | 50394352 |
Mandibular mass | 9.38 | 9.38 | 7 | 208586 | 175 | 50396356 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Chronic kidney disease | 519.65 | 9.86 | 702 | 124020 | 35714 | 29414091 |
Toxicity to various agents | 240.50 | 9.86 | 227 | 124495 | 173434 | 29276371 |
Death | 200.03 | 9.86 | 756 | 123966 | 341328 | 29108477 |
End stage renal disease | 193.32 | 9.86 | 198 | 124524 | 7466 | 29442339 |
Drug abuse | 178.93 | 9.86 | 57 | 124665 | 79826 | 29369979 |
Acute kidney injury | 168.14 | 9.86 | 1782 | 122940 | 263485 | 29186320 |
Drug ineffective | 166.78 | 9.86 | 878 | 123844 | 362292 | 29087513 |
Completed suicide | 165.54 | 9.86 | 87 | 124635 | 90159 | 29359646 |
Cholestasis | 142.01 | 9.86 | 309 | 124413 | 23153 | 29426652 |
Hepatocellular injury | 136.89 | 9.86 | 287 | 124435 | 20956 | 29428849 |
Toxic skin eruption | 126.87 | 9.86 | 180 | 124542 | 9577 | 29440228 |
Off label use | 126.53 | 9.86 | 748 | 123974 | 300052 | 29149753 |
Renal injury | 125.04 | 9.86 | 183 | 124539 | 10019 | 29439786 |
Interstitial lung disease | 124.59 | 9.86 | 528 | 124194 | 57190 | 29392615 |
Hypomagnesaemia | 92.27 | 9.86 | 218 | 124504 | 17250 | 29432555 |
Hepatic cytolysis | 91.30 | 9.86 | 142 | 124580 | 8205 | 29441600 |
Eosinophilia | 88.56 | 9.86 | 249 | 124473 | 21912 | 29427893 |
Treatment failure | 74.79 | 9.86 | 31 | 124691 | 36908 | 29412897 |
Hypocalcaemia | 72.81 | 9.86 | 222 | 124500 | 20443 | 29429362 |
Agranulocytosis | 72.12 | 9.86 | 219 | 124503 | 20121 | 29429684 |
Tubulointerstitial nephritis | 61.65 | 9.86 | 189 | 124533 | 17454 | 29432351 |
Nephrogenic anaemia | 60.72 | 9.86 | 57 | 124665 | 1928 | 29447877 |
Product use in unapproved indication | 57.88 | 9.86 | 181 | 124541 | 86694 | 29363111 |
Renal failure | 55.91 | 9.86 | 754 | 123968 | 117845 | 29331960 |
Drug reaction with eosinophilia and systemic symptoms | 52.74 | 9.86 | 246 | 124476 | 27746 | 29422059 |
Foetal exposure during pregnancy | 47.06 | 9.86 | 44 | 124678 | 33823 | 29415982 |
Hyperkalaemia | 46.67 | 9.86 | 429 | 124293 | 60963 | 29388842 |
Gamma-glutamyltransferase increased | 43.95 | 9.86 | 226 | 124496 | 26511 | 29423294 |
Hypertensive nephropathy | 42.30 | 9.86 | 25 | 124697 | 407 | 29449398 |
Drug resistance | 42.13 | 9.86 | 19 | 124703 | 21521 | 29428284 |
Occult blood | 40.71 | 9.86 | 27 | 124695 | 543 | 29449262 |
Gastrooesophageal reflux disease | 40.36 | 9.86 | 249 | 124473 | 31247 | 29418558 |
Degenerative mitral valve disease | 38.97 | 9.86 | 19 | 124703 | 205 | 29449600 |
Pancreatitis acute | 38.61 | 9.86 | 204 | 124518 | 24181 | 29425624 |
Hypergastrinaemia | 37.06 | 9.86 | 13 | 124709 | 54 | 29449751 |
Nicotine dependence | 37.06 | 9.86 | 24 | 124698 | 463 | 29449342 |
Thrombocytopenia | 36.32 | 9.86 | 783 | 123939 | 134040 | 29315765 |
Rash maculo-papular | 36.29 | 9.86 | 200 | 124522 | 24089 | 29425716 |
Pulmonary vascular disorder | 35.68 | 9.86 | 25 | 124697 | 552 | 29449253 |
Hepatitis cholestatic | 35.28 | 9.86 | 85 | 124637 | 6808 | 29442997 |
Lung disorder | 35.18 | 9.86 | 234 | 124488 | 30128 | 29419677 |
Hepatojugular reflux | 35.01 | 9.86 | 23 | 124699 | 455 | 29449350 |
Hyponatraemia | 34.77 | 9.86 | 437 | 124285 | 67196 | 29382609 |
Cholestatic liver injury | 34.29 | 9.86 | 39 | 124683 | 1658 | 29448147 |
COVID-19 | 33.47 | 9.86 | 63 | 124659 | 35951 | 29413854 |
Vascular purpura | 33.14 | 9.86 | 35 | 124687 | 1368 | 29448437 |
Colitis microscopic | 33.08 | 9.86 | 39 | 124683 | 1724 | 29448081 |
Hiatus hernia | 32.17 | 9.86 | 81 | 124641 | 6671 | 29443134 |
Ventricular hypokinesia | 32.14 | 9.86 | 64 | 124658 | 4501 | 29445304 |
Cell death | 31.56 | 9.86 | 41 | 124681 | 2003 | 29447802 |
Mixed liver injury | 31.45 | 9.86 | 41 | 124681 | 2010 | 29447795 |
Gastric polyps | 31.28 | 9.86 | 29 | 124693 | 965 | 29448840 |
Drug intolerance | 30.66 | 9.86 | 103 | 124619 | 48276 | 29401529 |
Jaundice | 30.53 | 9.86 | 220 | 124502 | 29076 | 29420729 |
Product dose omission issue | 29.93 | 9.86 | 261 | 124461 | 96122 | 29353683 |
Chronic kidney disease-mineral and bone disorder | 29.68 | 9.86 | 19 | 124703 | 359 | 29449446 |
Eye injury | 29.46 | 9.86 | 23 | 124699 | 602 | 29449203 |
Nephropathy | 29.23 | 9.86 | 67 | 124655 | 5196 | 29444609 |
Idiopathic pulmonary fibrosis | 28.04 | 9.86 | 49 | 124673 | 3119 | 29446686 |
Drug hypersensitivity | 27.07 | 9.86 | 173 | 124549 | 68233 | 29381572 |
Systolic dysfunction | 26.58 | 9.86 | 39 | 124683 | 2139 | 29447666 |
Intentional product use issue | 26.58 | 9.86 | 91 | 124631 | 42407 | 29407398 |
Intentional overdose | 26.54 | 9.86 | 79 | 124643 | 38449 | 29411356 |
Hypokalaemia | 26.49 | 9.86 | 326 | 124396 | 49877 | 29399928 |
Hemiplegia | 26.24 | 9.86 | 74 | 124648 | 6520 | 29443285 |
Gastric cancer | 25.49 | 9.86 | 60 | 124662 | 4734 | 29445071 |
Electrocardiogram Q wave abnormal | 25.15 | 9.86 | 16 | 124706 | 299 | 29449506 |
Physical deconditioning | 25.00 | 9.86 | 23 | 124699 | 758 | 29449047 |
Ureteric compression | 24.62 | 9.86 | 13 | 124709 | 168 | 29449637 |
Granulomatous rosacea | 24.02 | 9.86 | 12 | 124710 | 137 | 29449668 |
Therapeutic product effect incomplete | 24.01 | 9.86 | 85 | 124637 | 39220 | 29410585 |
Occupational dermatitis | 23.99 | 9.86 | 10 | 124712 | 72 | 29449733 |
Therapy non-responder | 23.82 | 9.86 | 60 | 124662 | 30851 | 29418954 |
Inferior vena cava dilatation | 23.76 | 9.86 | 21 | 124701 | 656 | 29449149 |
Eczema | 23.51 | 9.86 | 118 | 124604 | 13708 | 29436097 |
Diabetic nephropathy | 23.23 | 9.86 | 34 | 124688 | 1861 | 29447944 |
Disease progression | 23.19 | 9.86 | 227 | 124495 | 81689 | 29368116 |
Tubulointerstitial nephritis and uveitis syndrome | 23.09 | 9.86 | 10 | 124712 | 80 | 29449725 |
Gastroenteritis eosinophilic | 23.01 | 9.86 | 12 | 124710 | 151 | 29449654 |
Hypophosphataemic osteomalacia | 22.86 | 9.86 | 11 | 124711 | 115 | 29449690 |
Eosinophilic colitis | 22.81 | 9.86 | 13 | 124709 | 197 | 29449608 |
Helicobacter test positive | 22.17 | 9.86 | 20 | 124702 | 642 | 29449163 |
Cholangitis | 22.05 | 9.86 | 76 | 124646 | 7461 | 29442344 |
Ocular myasthenia | 21.92 | 9.86 | 13 | 124709 | 213 | 29449592 |
Brain scan abnormal | 21.50 | 9.86 | 22 | 124700 | 828 | 29448977 |
Hyperchlorhydria | 21.17 | 9.86 | 19 | 124703 | 606 | 29449199 |
Hyperthermia | 20.88 | 9.86 | 87 | 124635 | 9343 | 29440462 |
Acute generalised exanthematous pustulosis | 20.62 | 9.86 | 61 | 124661 | 5522 | 29444283 |
Adverse drug reaction | 20.62 | 9.86 | 44 | 124678 | 23976 | 29425829 |
Chest pain | 20.58 | 9.86 | 618 | 124104 | 111355 | 29338450 |
Acute pulmonary oedema | 20.39 | 9.86 | 69 | 124653 | 6710 | 29443095 |
Drug ineffective for unapproved indication | 20.30 | 9.86 | 18 | 124704 | 14196 | 29435609 |
Pain | 20.29 | 9.86 | 559 | 124163 | 170873 | 29278932 |
Cardiac failure | 20.21 | 9.86 | 457 | 124265 | 78830 | 29370975 |
Fixed eruption | 19.96 | 9.86 | 25 | 124697 | 1177 | 29448628 |
Overlap syndrome | 19.87 | 9.86 | 9 | 124713 | 81 | 29449724 |
Rhabdomyolysis | 19.63 | 9.86 | 363 | 124359 | 60445 | 29389360 |
Injection site pain | 19.27 | 9.86 | 71 | 124651 | 32375 | 29417430 |
Peripheral swelling | 19.16 | 9.86 | 174 | 124548 | 63565 | 29386240 |
Renal cyst | 19.15 | 9.86 | 75 | 124647 | 7832 | 29441973 |
Device dependence | 19.08 | 9.86 | 7 | 124715 | 34 | 29449771 |
Hyperkaliuria | 18.63 | 9.86 | 9 | 124713 | 95 | 29449710 |
Anaemia | 18.52 | 9.86 | 1030 | 123692 | 199921 | 29249884 |
Cardiac aneurysm | 18.52 | 9.86 | 20 | 124702 | 802 | 29449003 |
Face oedema | 18.36 | 9.86 | 89 | 124633 | 10194 | 29439611 |
Low birth weight baby | 18.18 | 9.86 | 3 | 124719 | 6605 | 29443200 |
Cardiac arrest | 18.10 | 9.86 | 253 | 124469 | 85338 | 29364467 |
Respiratory distress | 18.03 | 9.86 | 211 | 124511 | 31895 | 29417910 |
Radiation pneumonitis | 17.84 | 9.86 | 33 | 124689 | 2196 | 29447609 |
Contraindicated product administered | 17.82 | 9.86 | 31 | 124691 | 18235 | 29431570 |
Inappropriate antidiuretic hormone secretion | 17.68 | 9.86 | 92 | 124630 | 10840 | 29438965 |
Haematoma muscle | 17.67 | 9.86 | 21 | 124701 | 936 | 29448869 |
Phaeochromocytoma malignant | 17.67 | 9.86 | 8 | 124714 | 72 | 29449733 |
Anaemia macrocytic | 17.50 | 9.86 | 36 | 124686 | 2592 | 29447213 |
Cross sensitivity reaction | 17.47 | 9.86 | 24 | 124698 | 1238 | 29448567 |
Hepatic haematoma | 17.47 | 9.86 | 14 | 124708 | 381 | 29449424 |
Circumoral oedema | 17.46 | 9.86 | 7 | 124715 | 45 | 29449760 |
Acute coronary syndrome | 17.42 | 9.86 | 100 | 124622 | 12225 | 29437580 |
Craniotabes | 17.25 | 9.86 | 5 | 124717 | 9 | 29449796 |
Febrile bone marrow aplasia | 17.21 | 9.86 | 69 | 124653 | 7282 | 29442523 |
Eosinophilic oesophagitis | 17.18 | 9.86 | 11 | 124711 | 208 | 29449597 |
Premature baby | 17.16 | 9.86 | 29 | 124693 | 17251 | 29432554 |
Therapy interrupted | 17.03 | 9.86 | 7 | 124715 | 8379 | 29441426 |
Joint swelling | 16.94 | 9.86 | 131 | 124591 | 49499 | 29400306 |
Multiple sclerosis relapse | 16.87 | 9.86 | 14 | 124708 | 11405 | 29438400 |
Xerosis | 16.80 | 9.86 | 15 | 124707 | 475 | 29449330 |
Hypovitaminosis | 16.80 | 9.86 | 15 | 124707 | 475 | 29449330 |
No adverse event | 16.75 | 9.86 | 30 | 124692 | 17448 | 29432357 |
Occupational exposure to air contaminants | 16.73 | 9.86 | 9 | 124713 | 121 | 29449684 |
Immune-mediated hepatic disorder | 16.73 | 9.86 | 13 | 124709 | 338 | 29449467 |
Anticoagulation drug level increased | 16.70 | 9.86 | 15 | 124707 | 479 | 29449326 |
Haematotoxicity | 16.43 | 9.86 | 4 | 124718 | 6695 | 29443110 |
Poisoning | 16.37 | 9.86 | 11 | 124711 | 9982 | 29439823 |
Cardiac failure congestive | 16.32 | 9.86 | 226 | 124496 | 76355 | 29373450 |
Oesophagitis ulcerative | 16.12 | 9.86 | 17 | 124705 | 663 | 29449142 |
Pathogen resistance | 16.12 | 9.86 | 7 | 124715 | 8109 | 29441696 |
Nerve degeneration | 16.09 | 9.86 | 10 | 124712 | 179 | 29449626 |
Ischaemic stroke | 16.08 | 9.86 | 119 | 124603 | 15858 | 29433947 |
Duodenitis | 16.06 | 9.86 | 46 | 124676 | 4089 | 29445716 |
Antibody test abnormal | 16.05 | 9.86 | 9 | 124713 | 132 | 29449673 |
Brief psychotic disorder with marked stressors | 15.71 | 9.86 | 10 | 124712 | 187 | 29449618 |
Fatigue | 15.47 | 9.86 | 1139 | 123583 | 315682 | 29134123 |
Hospitalisation | 15.41 | 9.86 | 122 | 124600 | 45866 | 29403939 |
Venoocclusive liver disease | 15.35 | 9.86 | 5 | 124717 | 6912 | 29442893 |
Immune reconstitution inflammatory syndrome | 15.07 | 9.86 | 7 | 124715 | 7795 | 29442010 |
Aggression | 15.04 | 9.86 | 88 | 124634 | 35453 | 29414352 |
Cerebral artery thrombosis | 14.90 | 9.86 | 17 | 124705 | 725 | 29449080 |
Loss of personal independence in daily activities | 14.89 | 9.86 | 56 | 124666 | 25384 | 29424421 |
Lethargy | 14.88 | 9.86 | 95 | 124627 | 37485 | 29412320 |
Dermatitis exfoliative | 14.80 | 9.86 | 60 | 124662 | 6365 | 29443440 |
Hyperkinetic heart syndrome | 14.72 | 9.86 | 8 | 124714 | 110 | 29449695 |
Weight increased | 14.69 | 9.86 | 231 | 124491 | 76436 | 29373369 |
Peripheral venous disease | 14.46 | 9.86 | 31 | 124691 | 2297 | 29447508 |
Renal haemangioma | 14.40 | 9.86 | 5 | 124717 | 20 | 29449785 |
Antiphospholipid antibodies positive | 14.39 | 9.86 | 11 | 124711 | 279 | 29449526 |
Neuroleptic malignant syndrome | 14.35 | 9.86 | 29 | 124693 | 16119 | 29433686 |
Cancer pain | 14.29 | 9.86 | 31 | 124691 | 2316 | 29447489 |
High frequency ablation | 14.20 | 9.86 | 9 | 124713 | 167 | 29449638 |
Oesophageal adenocarcinoma | 14.13 | 9.86 | 17 | 124705 | 768 | 29449037 |
Respiratory depression | 14.08 | 9.86 | 22 | 124700 | 13501 | 29436304 |
Neurotoxicity | 14.08 | 9.86 | 25 | 124697 | 14588 | 29435217 |
Tachycardia | 13.93 | 9.86 | 218 | 124504 | 72192 | 29377613 |
Stevens-Johnson syndrome | 13.92 | 9.86 | 118 | 124604 | 16379 | 29433426 |
Prurigo | 13.90 | 9.86 | 15 | 124707 | 601 | 29449204 |
Coronary artery stenosis | 13.76 | 9.86 | 72 | 124650 | 8501 | 29441304 |
Accidental exposure to product | 13.76 | 9.86 | 15 | 124707 | 10738 | 29439067 |
Fracture delayed union | 13.65 | 9.86 | 6 | 124716 | 50 | 29449755 |
Muscle haemorrhage | 13.64 | 9.86 | 38 | 124684 | 3324 | 29446481 |
Hepatic encephalopathy | 13.64 | 9.86 | 98 | 124624 | 12937 | 29436868 |
Essential tremor | 13.59 | 9.86 | 16 | 124706 | 706 | 29449099 |
Ventricular enlargement | 13.58 | 9.86 | 13 | 124709 | 451 | 29449354 |
Thrombocytopenic purpura | 13.54 | 9.86 | 19 | 124703 | 1000 | 29448805 |
Dyspepsia | 13.53 | 9.86 | 190 | 124532 | 29935 | 29419870 |
Sacroiliitis | 13.49 | 9.86 | 20 | 124702 | 1107 | 29448698 |
Bronchial injury | 13.42 | 9.86 | 3 | 124719 | 0 | 29449805 |
Acquired cystic kidney disease | 13.42 | 9.86 | 3 | 124719 | 0 | 29449805 |
Mitral valve incompetence | 13.37 | 9.86 | 99 | 124623 | 13194 | 29436611 |
Benign abdominal neoplasm | 13.36 | 9.86 | 7 | 124715 | 89 | 29449716 |
Vitamin B12 deficiency | 13.30 | 9.86 | 37 | 124685 | 3234 | 29446571 |
Pancreatitis | 13.29 | 9.86 | 212 | 124510 | 34302 | 29415503 |
Neutropenic sepsis | 13.27 | 9.86 | 18 | 124704 | 11709 | 29438096 |
Hepatitis | 13.22 | 9.86 | 140 | 124582 | 20643 | 29429162 |
Crohn's disease | 13.20 | 9.86 | 35 | 124687 | 2974 | 29446831 |
Oesophageal dilatation | 13.18 | 9.86 | 8 | 124714 | 137 | 29449668 |
Hypotension | 13.09 | 9.86 | 678 | 124044 | 193676 | 29256129 |
Rebound acid hypersecretion | 13.02 | 9.86 | 7 | 124715 | 94 | 29449711 |
Excessive cerumen production | 12.93 | 9.86 | 10 | 124712 | 258 | 29449547 |
Prostatitis Escherichia coli | 12.90 | 9.86 | 5 | 124717 | 29 | 29449776 |
Mucormycosis | 12.81 | 9.86 | 3 | 124719 | 5155 | 29444650 |
Dermatitis bullous | 12.70 | 9.86 | 54 | 124668 | 5852 | 29443953 |
Blood alkaline phosphatase increased | 12.70 | 9.86 | 179 | 124543 | 28227 | 29421578 |
Chest expansion decreased | 12.69 | 9.86 | 8 | 124714 | 147 | 29449658 |
Respiratory arrest | 12.58 | 9.86 | 61 | 124661 | 25772 | 29424033 |
Myoglobinaemia | 12.52 | 9.86 | 7 | 124715 | 102 | 29449703 |
Eructation | 12.25 | 9.86 | 41 | 124681 | 3965 | 29445840 |
Ventricular arrhythmia | 12.24 | 9.86 | 45 | 124677 | 4559 | 29445246 |
Sensitisation | 12.19 | 9.86 | 8 | 124714 | 158 | 29449647 |
Bicytopenia | 12.13 | 9.86 | 25 | 124697 | 1802 | 29448003 |
Abdominal pain upper | 12.11 | 9.86 | 340 | 124382 | 60653 | 29389152 |
Exposure during pregnancy | 12.01 | 9.86 | 11 | 124711 | 8543 | 29441262 |
Renal tubular disorder | 11.97 | 9.86 | 43 | 124679 | 4309 | 29445496 |
Cholecystitis | 11.96 | 9.86 | 73 | 124649 | 9124 | 29440681 |
Intestinal obstruction | 11.87 | 9.86 | 129 | 124593 | 19148 | 29430657 |
Jaundice cholestatic | 11.83 | 9.86 | 42 | 124680 | 4184 | 29445621 |
Psychotic disorder | 11.78 | 9.86 | 45 | 124677 | 20309 | 29429496 |
Sepsis | 11.76 | 9.86 | 487 | 124235 | 142195 | 29307610 |
Myelosuppression | 11.70 | 9.86 | 21 | 124701 | 12206 | 29437599 |
Lumbar radiculopathy | 11.66 | 9.86 | 15 | 124707 | 726 | 29449079 |
Hyperparathyroidism secondary | 11.65 | 9.86 | 20 | 124702 | 1255 | 29448550 |
Intentional product misuse | 11.59 | 9.86 | 92 | 124630 | 34569 | 29415236 |
Febrile neutropenia | 11.52 | 9.86 | 373 | 124349 | 111867 | 29337938 |
Microcytic anaemia | 11.44 | 9.86 | 26 | 124696 | 2005 | 29447800 |
Toxic epidermal necrolysis | 11.42 | 9.86 | 122 | 124600 | 18031 | 29431774 |
Progressive multifocal leukoencephalopathy | 11.34 | 9.86 | 12 | 124710 | 8707 | 29441098 |
Oral pustule | 11.32 | 9.86 | 9 | 124713 | 242 | 29449563 |
Septic arthritis staphylococcal | 11.32 | 9.86 | 12 | 124710 | 471 | 29449334 |
Poisoning deliberate | 11.29 | 9.86 | 5 | 124717 | 5726 | 29444079 |
Essential hypertension | 11.24 | 9.86 | 29 | 124693 | 2424 | 29447381 |
Renal atrophy | 11.21 | 9.86 | 18 | 124704 | 1069 | 29448736 |
Carotid arteriosclerosis | 11.15 | 9.86 | 21 | 124701 | 1417 | 29448388 |
Erythema of eyelid | 11.10 | 9.86 | 14 | 124708 | 664 | 29449141 |
Carbohydrate antigen 19-9 increased | 11.10 | 9.86 | 8 | 124714 | 185 | 29449620 |
Synovitis | 11.07 | 9.86 | 18 | 124704 | 10872 | 29438933 |
Conjunctival ulcer | 11.04 | 9.86 | 5 | 124717 | 45 | 29449760 |
Acute graft versus host disease in skin | 11.03 | 9.86 | 3 | 124719 | 4661 | 29445144 |
Cardiorenal syndrome | 10.97 | 9.86 | 14 | 124708 | 672 | 29449133 |
Musculoskeletal stiffness | 10.93 | 9.86 | 103 | 124619 | 37355 | 29412450 |
Sudden death | 10.91 | 9.86 | 99 | 124623 | 14011 | 29435794 |
Injection site reaction | 10.90 | 9.86 | 19 | 124703 | 11169 | 29438636 |
Hyperplastic cholecystopathy | 10.89 | 9.86 | 3 | 124719 | 4 | 29449801 |
Septic shock | 10.87 | 9.86 | 343 | 124379 | 62217 | 29387588 |
Food interaction | 10.82 | 9.86 | 16 | 124706 | 884 | 29448921 |
Bronchomalacia | 10.76 | 9.86 | 6 | 124716 | 87 | 29449718 |
Unresponsive to stimuli | 10.74 | 9.86 | 62 | 124660 | 25064 | 29424741 |
Nephropathy toxic | 10.73 | 9.86 | 18 | 124704 | 10738 | 29439067 |
Heat stroke | 10.70 | 9.86 | 16 | 124706 | 893 | 29448912 |
Laboratory test abnormal | 10.66 | 9.86 | 40 | 124682 | 18145 | 29431660 |
Enterochromaffin cell hyperplasia | 10.65 | 9.86 | 4 | 124718 | 21 | 29449784 |
Gastric cancer stage 0 | 10.65 | 9.86 | 4 | 124718 | 21 | 29449784 |
Hypercalciuria | 10.60 | 9.86 | 9 | 124713 | 266 | 29449539 |
Drug dependence | 10.53 | 9.86 | 49 | 124673 | 20932 | 29428873 |
Anal erosion | 10.50 | 9.86 | 4 | 124718 | 22 | 29449783 |
Hypotrichosis | 10.50 | 9.86 | 4 | 124718 | 22 | 29449783 |
Abnormal behaviour | 10.47 | 9.86 | 56 | 124666 | 23071 | 29426734 |
Infective exacerbation of chronic obstructive airways disease | 10.28 | 9.86 | 22 | 124700 | 1628 | 29448177 |
Coombs negative haemolytic anaemia | 10.25 | 9.86 | 7 | 124715 | 148 | 29449657 |
Hyperphosphatasaemia | 10.21 | 9.86 | 4 | 124718 | 24 | 29449781 |
Malnutrition | 10.17 | 9.86 | 80 | 124642 | 10861 | 29438944 |
Microcytosis | 10.17 | 9.86 | 7 | 124715 | 150 | 29449655 |
Platelet toxicity | 10.15 | 9.86 | 3 | 124719 | 6 | 29449799 |
Barrett's oesophagus | 10.15 | 9.86 | 11 | 124711 | 443 | 29449362 |
Renal mass | 10.14 | 9.86 | 21 | 124701 | 1519 | 29448286 |
Creatinine renal clearance abnormal | 10.13 | 9.86 | 8 | 124714 | 213 | 29449592 |
Drug interaction | 10.11 | 9.86 | 965 | 123757 | 196420 | 29253385 |
Diverticulum | 10.04 | 9.86 | 53 | 124669 | 6279 | 29443526 |
Hepatotoxicity | 10.02 | 9.86 | 40 | 124682 | 17827 | 29431978 |
Duodenal polyp | 9.97 | 9.86 | 7 | 124715 | 155 | 29449650 |
Epstein-Barr virus infection | 9.95 | 9.86 | 8 | 124714 | 6621 | 29443184 |
Biliary anastomosis complication | 9.93 | 9.86 | 6 | 124716 | 102 | 29449703 |
Nasal crusting | 9.89 | 9.86 | 10 | 124712 | 371 | 29449434 |
Haemorrhage intracranial | 9.88 | 9.86 | 30 | 124692 | 14512 | 29435293 |
Hepatocellular carcinoma | 9.88 | 9.86 | 57 | 124665 | 6981 | 29442824 |
Oesophageal candidiasis | 9.87 | 9.86 | 37 | 124685 | 3784 | 29446021 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Chronic kidney disease | 570.04 | 9.30 | 935 | 269183 | 56984 | 64171630 |
Completed suicide | 442.35 | 9.30 | 193 | 269925 | 224221 | 64004393 |
Drug ineffective | 374.67 | 9.30 | 2033 | 268085 | 838214 | 63390400 |
Toxicity to various agents | 369.05 | 9.30 | 596 | 269522 | 362917 | 63865697 |
Hepatocellular injury | 304.88 | 9.30 | 620 | 269498 | 44615 | 64183999 |
Cholestasis | 287.11 | 9.30 | 602 | 269516 | 44270 | 64184344 |
Interstitial lung disease | 275.12 | 9.30 | 968 | 269150 | 96764 | 64131850 |
Acute kidney injury | 246.95 | 9.30 | 2920 | 267198 | 446320 | 63782294 |
Death | 245.84 | 9.30 | 1113 | 269005 | 481592 | 63747022 |
Off label use | 238.28 | 9.30 | 1613 | 268505 | 631193 | 63597421 |
Drug abuse | 216.57 | 9.30 | 144 | 269974 | 132230 | 64096384 |
Synovitis | 211.89 | 9.30 | 75 | 270043 | 99015 | 64129599 |
End stage renal disease | 206.72 | 9.30 | 237 | 269881 | 10238 | 64218376 |
Pemphigus | 191.33 | 9.30 | 17 | 270101 | 60684 | 64167930 |
Toxic skin eruption | 174.54 | 9.30 | 300 | 269818 | 18984 | 64209630 |
Hand deformity | 174.54 | 9.30 | 27 | 270091 | 62744 | 64165870 |
Maternal exposure during pregnancy | 166.93 | 9.30 | 97 | 270021 | 95787 | 64132827 |
Anti-cyclic citrullinated peptide antibody positive | 158.62 | 9.30 | 13 | 270105 | 49549 | 64179065 |
Eosinophilia | 157.15 | 9.30 | 431 | 269687 | 37645 | 64190969 |
Carotid artery thrombosis | 150.98 | 9.30 | 94 | 270024 | 1701 | 64226913 |
Hypomagnesaemia | 150.22 | 9.30 | 419 | 269699 | 36957 | 64191657 |
Agranulocytosis | 150.15 | 9.30 | 425 | 269693 | 37804 | 64190810 |
Hyponatraemia | 148.44 | 9.30 | 1097 | 269021 | 147242 | 64081372 |
Neurologic neglect syndrome | 144.41 | 9.30 | 88 | 270030 | 1530 | 64227084 |
Cholecystitis chronic | 136.25 | 9.30 | 181 | 269937 | 9106 | 64219508 |
Glossodynia | 133.20 | 9.30 | 52 | 270066 | 64644 | 64163970 |
Hypocalcaemia | 131.90 | 9.30 | 430 | 269688 | 41323 | 64187291 |
Product use in unapproved indication | 127.31 | 9.30 | 351 | 269767 | 176267 | 64052347 |
Systemic lupus erythematosus | 119.57 | 9.30 | 90 | 270028 | 77522 | 64151092 |
Hemiplegia | 118.67 | 9.30 | 201 | 269917 | 12567 | 64216047 |
Rheumatoid factor positive | 118.08 | 9.30 | 7 | 270111 | 34931 | 64193683 |
Adjustment disorder | 115.03 | 9.30 | 94 | 270024 | 2651 | 64225963 |
Drug intolerance | 114.70 | 9.30 | 403 | 269715 | 187589 | 64041025 |
Duodenal ulcer perforation | 113.86 | 9.30 | 8 | 270110 | 34617 | 64193997 |
Treatment failure | 113.19 | 9.30 | 197 | 269921 | 116619 | 64111995 |
Contraindicated product administered | 112.74 | 9.30 | 173 | 269945 | 107656 | 64120958 |
Alopecia | 111.58 | 9.30 | 340 | 269778 | 165350 | 64063264 |
Wound | 108.71 | 9.30 | 96 | 270022 | 76381 | 64152233 |
Renal injury | 108.13 | 9.30 | 215 | 269903 | 15214 | 64213400 |
Renal failure | 103.87 | 9.30 | 1191 | 268927 | 180497 | 64048117 |
Arthropathy | 103.25 | 9.30 | 220 | 269898 | 120747 | 64107867 |
Biliary dyskinesia | 103.14 | 9.30 | 83 | 270035 | 2289 | 64226325 |
Joint swelling | 100.92 | 9.30 | 511 | 269607 | 214871 | 64013743 |
Gastrooesophageal reflux disease | 99.76 | 9.30 | 643 | 269475 | 82500 | 64146114 |
Rash maculo-papular | 98.94 | 9.30 | 425 | 269693 | 46601 | 64182013 |
Personality disorder | 98.77 | 9.30 | 110 | 270008 | 4601 | 64224013 |
Hepatic cytolysis | 98.73 | 9.30 | 196 | 269922 | 13853 | 64214761 |
Tubulointerstitial nephritis | 95.53 | 9.30 | 316 | 269802 | 30593 | 64198021 |
Drug reaction with eosinophilia and systemic symptoms | 94.06 | 9.30 | 463 | 269655 | 53754 | 64174860 |
Pericarditis | 89.43 | 9.30 | 78 | 270040 | 62438 | 64166176 |
Infusion related reaction | 89.04 | 9.30 | 370 | 269748 | 164097 | 64064517 |
Peripheral swelling | 86.58 | 9.30 | 517 | 269601 | 208636 | 64019978 |
Intentional overdose | 80.63 | 9.30 | 159 | 269959 | 89785 | 64138829 |
Intentional product use issue | 80.08 | 9.30 | 175 | 269943 | 95189 | 64133425 |
Exposure during pregnancy | 79.87 | 9.30 | 126 | 269992 | 77549 | 64151065 |
Sensitisation | 78.32 | 9.30 | 62 | 270056 | 1669 | 64226945 |
Nephrogenic anaemia | 77.32 | 9.30 | 82 | 270036 | 3243 | 64225371 |
Gamma-glutamyltransferase increased | 76.27 | 9.30 | 403 | 269715 | 48107 | 64180507 |
Drug resistance | 74.28 | 9.30 | 27 | 270091 | 35075 | 64193539 |
Inappropriate antidiuretic hormone secretion | 72.60 | 9.30 | 232 | 269886 | 22057 | 64206557 |
Gastric polyps | 72.30 | 9.30 | 75 | 270043 | 2890 | 64225724 |
Acute generalised exanthematous pustulosis | 70.23 | 9.30 | 171 | 269947 | 13887 | 64214727 |
Swelling | 70.06 | 9.30 | 389 | 269729 | 159829 | 64068785 |
Vascular purpura | 66.59 | 9.30 | 67 | 270051 | 2489 | 64226125 |
Lung disorder | 66.51 | 9.30 | 459 | 269659 | 60241 | 64168373 |
Dysphagia | 66.39 | 9.30 | 712 | 269406 | 106100 | 64122514 |
Folliculitis | 65.59 | 9.30 | 22 | 270096 | 30055 | 64198559 |
Helicobacter infection | 65.07 | 9.30 | 40 | 270078 | 38322 | 64190292 |
Discomfort | 64.19 | 9.30 | 153 | 269965 | 80725 | 64147889 |
Abdominal pain upper | 63.83 | 9.30 | 1059 | 269059 | 173971 | 64054643 |
Muscle injury | 63.78 | 9.30 | 16 | 270102 | 26421 | 64202193 |
Hiatus hernia | 63.44 | 9.30 | 206 | 269912 | 19751 | 64208863 |
Hypertensive nephropathy | 63.16 | 9.30 | 41 | 270077 | 800 | 64227814 |
Polycystic ovaries | 60.80 | 9.30 | 59 | 270059 | 2096 | 64226518 |
Fatigue | 59.73 | 9.30 | 2547 | 267571 | 746183 | 63482431 |
Hepatic enzyme increased | 58.73 | 9.30 | 312 | 269806 | 129631 | 64098983 |
Therapeutic product effect decreased | 58.45 | 9.30 | 266 | 269852 | 115085 | 64113529 |
Hypokalaemia | 57.08 | 9.30 | 770 | 269348 | 121133 | 64107481 |
Ejection fraction | 55.92 | 9.30 | 45 | 270073 | 1241 | 64227373 |
Cholestatic liver injury | 54.42 | 9.30 | 72 | 270046 | 3607 | 64225007 |
Motor dysfunction | 53.29 | 9.30 | 135 | 269983 | 11238 | 64217376 |
Hypergastrinaemia | 52.97 | 9.30 | 22 | 270096 | 158 | 64228456 |
Pancreatitis acute | 52.97 | 9.30 | 334 | 269784 | 42521 | 64186093 |
Bronchial neoplasm | 52.59 | 9.30 | 29 | 270089 | 414 | 64228200 |
Affect lability | 49.96 | 9.30 | 114 | 270004 | 8876 | 64219738 |
Anaemia | 49.05 | 9.30 | 1995 | 268123 | 376685 | 63851929 |
Rhinitis allergic | 48.90 | 9.30 | 106 | 270012 | 7972 | 64220642 |
Pancreatitis | 47.68 | 9.30 | 419 | 269699 | 59188 | 64169426 |
Hyperkalaemia | 47.43 | 9.30 | 639 | 269479 | 100490 | 64128124 |
Gastritis | 47.11 | 9.30 | 323 | 269795 | 42295 | 64186319 |
C-reactive protein abnormal | 46.93 | 9.30 | 32 | 270086 | 29015 | 64199599 |
Hepatitis cholestatic | 46.61 | 9.30 | 134 | 269984 | 12021 | 64216593 |
COVID-19 | 46.48 | 9.30 | 130 | 269988 | 65010 | 64163604 |
Product use issue | 45.43 | 9.30 | 411 | 269707 | 151304 | 64077310 |
Presbyacusis | 45.40 | 9.30 | 55 | 270063 | 2520 | 64226094 |
Gallbladder disorder | 44.73 | 9.30 | 165 | 269953 | 16865 | 64211749 |
Mixed liver injury | 44.10 | 9.30 | 81 | 270037 | 5400 | 64223214 |
Thrombocytopenia | 43.95 | 9.30 | 1238 | 268880 | 222563 | 64006051 |
Sleep disorder due to general medical condition, insomnia type | 43.71 | 9.30 | 28 | 270090 | 26242 | 64202372 |
Injection site pain | 43.66 | 9.30 | 280 | 269838 | 111128 | 64117486 |
Therapeutic response decreased | 43.61 | 9.30 | 96 | 270022 | 52092 | 64176522 |
Device expulsion | 43.48 | 9.30 | 17 | 270101 | 21119 | 64207495 |
Cell death | 43.34 | 9.30 | 68 | 270050 | 3986 | 64224628 |
Therapy non-responder | 42.37 | 9.30 | 138 | 269980 | 65761 | 64162853 |
Systemic lupus erythematosus rash | 42.07 | 9.30 | 40 | 270078 | 1385 | 64227229 |
Coordination abnormal | 41.87 | 9.30 | 148 | 269970 | 14816 | 64213798 |
Dermatitis bullous | 41.59 | 9.30 | 128 | 269990 | 11926 | 64216688 |
Jaundice | 41.42 | 9.30 | 346 | 269772 | 48166 | 64180448 |
Pregnancy | 40.95 | 9.30 | 18 | 270100 | 20847 | 64207767 |
Pleural thickening | 40.03 | 9.30 | 53 | 270065 | 2657 | 64225957 |
Sensory loss | 39.87 | 9.30 | 113 | 270005 | 10056 | 64218558 |
Epigastric discomfort | 39.67 | 9.30 | 88 | 270030 | 6723 | 64221891 |
Cross sensitivity reaction | 39.55 | 9.30 | 59 | 270059 | 3308 | 64225306 |
Psoriatic arthropathy | 39.22 | 9.30 | 76 | 270042 | 43205 | 64185409 |
Pain | 38.94 | 9.30 | 1908 | 268210 | 551603 | 63677011 |
Nephropathy | 38.73 | 9.30 | 99 | 270019 | 8287 | 64220327 |
Cardiac arrest | 38.41 | 9.30 | 436 | 269682 | 153628 | 64074986 |
Condition aggravated | 38.28 | 9.30 | 1228 | 268890 | 371198 | 63857416 |
Cholecystitis | 37.91 | 9.30 | 173 | 269945 | 19463 | 64209151 |
Rhabdomyolysis | 37.57 | 9.30 | 566 | 269552 | 91160 | 64137454 |
Gallbladder injury | 37.32 | 9.30 | 34 | 270084 | 1114 | 64227500 |
Angina pectoris | 37.15 | 9.30 | 319 | 269799 | 44762 | 64183852 |
Poisoning | 36.85 | 9.30 | 23 | 270095 | 21856 | 64206758 |
Degenerative mitral valve disease | 36.62 | 9.30 | 19 | 270099 | 238 | 64228376 |
Lower respiratory tract infection | 36.46 | 9.30 | 239 | 269879 | 94375 | 64134239 |
Nasal turbinate hypertrophy | 35.91 | 9.30 | 25 | 270093 | 550 | 64228064 |
Cardiac failure | 35.82 | 9.30 | 765 | 269353 | 131608 | 64097006 |
Neutropenic sepsis | 35.81 | 9.30 | 27 | 270091 | 23245 | 64205369 |
Loss of employment | 35.71 | 9.30 | 42 | 270076 | 1865 | 64226749 |
Hypersensitivity | 35.66 | 9.30 | 593 | 269525 | 195859 | 64032755 |
Device dependence | 35.46 | 9.30 | 12 | 270106 | 44 | 64228570 |
Pleural fibrosis | 35.33 | 9.30 | 62 | 270056 | 3988 | 64224626 |
Therapy interrupted | 35.24 | 9.30 | 20 | 270098 | 20016 | 64208598 |
Accidental exposure to product | 35.21 | 9.30 | 35 | 270083 | 26329 | 64202285 |
Nephrectomy | 34.73 | 9.30 | 36 | 270082 | 1386 | 64227228 |
Iron deficiency anaemia | 34.50 | 9.30 | 182 | 269936 | 21707 | 64206907 |
Hypothyroidism | 34.24 | 9.30 | 288 | 269830 | 40169 | 64188445 |
Ill-defined disorder | 32.87 | 9.30 | 86 | 270032 | 43966 | 64184648 |
Haematotoxicity | 32.71 | 9.30 | 7 | 270111 | 12889 | 64215725 |
Nasopharyngitis | 32.66 | 9.30 | 601 | 269517 | 195472 | 64033142 |
Osteosclerosis | 32.55 | 9.30 | 55 | 270063 | 3431 | 64225183 |
Sedation complication | 32.35 | 9.30 | 3 | 270115 | 10351 | 64218263 |
Eczema | 32.11 | 9.30 | 224 | 269894 | 29496 | 64199118 |
Muscle haemorrhage | 32.02 | 9.30 | 73 | 270045 | 5680 | 64222934 |
Respiratory arrest | 31.99 | 9.30 | 114 | 270004 | 52871 | 64175743 |
Diabetic nephropathy | 31.89 | 9.30 | 47 | 270071 | 2607 | 64226007 |
Hepatitis | 31.71 | 9.30 | 311 | 269807 | 45271 | 64183343 |
Blood magnesium increased | 31.54 | 9.30 | 52 | 270066 | 3179 | 64225435 |
Chronic kidney disease-mineral and bone disorder | 31.41 | 9.30 | 22 | 270096 | 489 | 64228125 |
Abdominal discomfort | 31.26 | 9.30 | 556 | 269562 | 181766 | 64046848 |
Cholangitis | 31.23 | 9.30 | 108 | 270010 | 10694 | 64217920 |
Eating disorder | 30.93 | 9.30 | 146 | 269972 | 16659 | 64211955 |
Hepatojugular reflux | 30.79 | 9.30 | 22 | 270096 | 505 | 64228109 |
Premature delivery | 30.68 | 9.30 | 20 | 270098 | 18569 | 64210045 |
Endometrial ablation | 30.60 | 9.30 | 26 | 270092 | 775 | 64227839 |
Neurotoxicity | 30.56 | 9.30 | 42 | 270076 | 27362 | 64201252 |
Idiopathic pulmonary fibrosis | 30.37 | 9.30 | 56 | 270062 | 3744 | 64224870 |
Drug hypersensitivity | 30.03 | 9.30 | 762 | 269356 | 237053 | 63991561 |
Drug ineffective for unapproved indication | 29.69 | 9.30 | 53 | 270065 | 31080 | 64197534 |
Urate nephropathy | 29.56 | 9.30 | 14 | 270104 | 142 | 64228472 |
Mobility decreased | 28.63 | 9.30 | 226 | 269892 | 85614 | 64143000 |
Occupational dermatitis | 28.60 | 9.30 | 13 | 270105 | 119 | 64228495 |
Tenosynovitis stenosans | 28.44 | 9.30 | 38 | 270080 | 1922 | 64226692 |
Chest pain | 28.40 | 9.30 | 1234 | 268884 | 234746 | 63993868 |
Myelosuppression | 28.13 | 9.30 | 35 | 270083 | 23795 | 64204819 |
Bone erosion | 28.00 | 9.30 | 7 | 270111 | 11588 | 64217026 |
Disease progression | 27.94 | 9.30 | 421 | 269697 | 141259 | 64087355 |
Irritable bowel syndrome | 27.84 | 9.30 | 73 | 270045 | 37296 | 64191318 |
Injection site erythema | 27.70 | 9.30 | 178 | 269940 | 70622 | 64157992 |
Oesophagitis ulcerative | 27.69 | 9.30 | 26 | 270092 | 886 | 64227728 |
Gastric cancer | 27.28 | 9.30 | 74 | 270044 | 6419 | 64222195 |
Post transplant lymphoproliferative disorder | 26.77 | 9.30 | 4 | 270114 | 9540 | 64219074 |
Hip arthroplasty | 26.66 | 9.30 | 30 | 270088 | 21321 | 64207293 |
Blister | 26.62 | 9.30 | 214 | 269904 | 80753 | 64147861 |
Occult blood | 26.45 | 9.30 | 31 | 270087 | 1371 | 64227243 |
Musculoskeletal stiffness | 26.44 | 9.30 | 360 | 269758 | 122846 | 64105768 |
Dry eye | 26.40 | 9.30 | 210 | 269908 | 28809 | 64199805 |
Red blood cell sedimentation rate abnormal | 26.29 | 9.30 | 18 | 270100 | 16288 | 64212326 |
Anaemia macrocytic | 25.81 | 9.30 | 57 | 270061 | 4341 | 64224273 |
Gallbladder polyp | 25.79 | 9.30 | 25 | 270093 | 887 | 64227727 |
Erythema dyschromicum perstans | 25.73 | 9.30 | 10 | 270108 | 59 | 64228555 |
Knee arthroplasty | 25.71 | 9.30 | 46 | 270072 | 26953 | 64201661 |
Hyperthermia | 25.69 | 9.30 | 131 | 269987 | 15419 | 64213195 |
Respiratory distress | 25.49 | 9.30 | 333 | 269785 | 51998 | 64176616 |
Pulmonary vascular disorder | 25.40 | 9.30 | 25 | 270093 | 904 | 64227710 |
Neuroleptic malignant syndrome | 25.26 | 9.30 | 41 | 270077 | 24955 | 64203659 |
Bone cyst | 25.10 | 9.30 | 38 | 270080 | 2159 | 64226455 |
Respiratory depression | 25.08 | 9.30 | 37 | 270081 | 23406 | 64205208 |
Sleep apnoea syndrome | 25.05 | 9.30 | 212 | 269906 | 29620 | 64198994 |
Cholelithiasis | 24.93 | 9.30 | 296 | 269822 | 45210 | 64183404 |
Axonal neuropathy | 24.85 | 9.30 | 33 | 270085 | 1659 | 64226955 |
Hepatotoxicity | 24.79 | 9.30 | 85 | 270033 | 39877 | 64188737 |
Bronchial disorder | 24.76 | 9.30 | 37 | 270081 | 2078 | 64226536 |
Bronchial haemorrhage | 24.71 | 9.30 | 28 | 270090 | 1194 | 64227420 |
Ureteric compression | 24.57 | 9.30 | 13 | 270105 | 170 | 64228444 |
Weight increased | 24.47 | 9.30 | 693 | 269425 | 212655 | 64015959 |
Nicotine dependence | 24.32 | 9.30 | 23 | 270095 | 791 | 64227823 |
Aphasia | 24.16 | 9.30 | 270 | 269848 | 40636 | 64187978 |
Tetany | 24.01 | 9.30 | 37 | 270081 | 2135 | 64226479 |
Injection site pruritus | 23.77 | 9.30 | 80 | 270038 | 37746 | 64190868 |
Lip oedema | 23.69 | 9.30 | 61 | 270057 | 5128 | 64223486 |
Synovial fluid analysis | 23.66 | 9.30 | 31 | 270087 | 1538 | 64227076 |
Abdominal pain | 23.64 | 9.30 | 1564 | 268554 | 310811 | 63917803 |
Face oedema | 23.53 | 9.30 | 181 | 269937 | 24580 | 64204034 |
Blood alkaline phosphatase increased | 23.32 | 9.30 | 348 | 269770 | 55931 | 64172683 |
Caesarean section | 23.30 | 9.30 | 9 | 270109 | 11265 | 64217349 |
Febrile bone marrow aplasia | 23.11 | 9.30 | 101 | 270017 | 11154 | 64217460 |
Hemiparesis | 22.99 | 9.30 | 208 | 269910 | 29619 | 64198995 |
Malnutrition | 22.98 | 9.30 | 148 | 269970 | 18977 | 64209637 |
Laboratory test abnormal | 22.91 | 9.30 | 41 | 270077 | 24022 | 64204592 |
Injection site bruising | 22.81 | 9.30 | 77 | 270041 | 36296 | 64192318 |
Aggression | 22.59 | 9.30 | 108 | 270010 | 46124 | 64182490 |
Medication error | 22.54 | 9.30 | 120 | 269998 | 49846 | 64178768 |
Colitis microscopic | 22.09 | 9.30 | 75 | 270043 | 7357 | 64221257 |
Abortion spontaneous | 22.05 | 9.30 | 45 | 270073 | 25098 | 64203516 |
Rash | 22.01 | 9.30 | 1638 | 268480 | 456911 | 63771703 |
Inferior vena cava dilatation | 21.95 | 9.30 | 21 | 270097 | 733 | 64227881 |
Pyelocaliectasis | 21.89 | 9.30 | 22 | 270096 | 816 | 64227798 |
Phlebitis | 21.89 | 9.30 | 77 | 270041 | 7689 | 64220925 |
Carpal tunnel syndrome | 21.87 | 9.30 | 127 | 269991 | 15701 | 64212913 |
Chronic cutaneous lupus erythematosus | 21.80 | 9.30 | 13 | 270105 | 217 | 64228397 |
Cerebral haematoma | 21.79 | 9.30 | 73 | 270045 | 7112 | 64221502 |
Acute coronary syndrome | 21.72 | 9.30 | 147 | 269971 | 19163 | 64209451 |
Eosinophilic colitis | 21.68 | 9.30 | 16 | 270102 | 387 | 64228227 |
Pathogen resistance | 21.38 | 9.30 | 13 | 270105 | 12530 | 64216084 |
Dermatitis exfoliative | 21.34 | 9.30 | 93 | 270025 | 10259 | 64218355 |
Helicobacter test positive | 21.05 | 9.30 | 24 | 270094 | 1030 | 64227584 |
Hypovitaminosis | 20.83 | 9.30 | 22 | 270096 | 866 | 64227748 |
Mucormycosis | 20.76 | 9.30 | 3 | 270115 | 7338 | 64221276 |
Hyperparathyroidism secondary | 20.76 | 9.30 | 36 | 270082 | 2294 | 64226320 |
Product dose omission issue | 20.73 | 9.30 | 639 | 269479 | 194108 | 64034506 |
Unresponsive to stimuli | 20.59 | 9.30 | 125 | 269993 | 50268 | 64178346 |
Injection site swelling | 20.56 | 9.30 | 96 | 270022 | 41257 | 64187357 |
Deafness neurosensory | 20.44 | 9.30 | 66 | 270052 | 6308 | 64222306 |
Hyperchlorhydria | 20.39 | 9.30 | 31 | 270087 | 1768 | 64226846 |
Osteopenia | 20.38 | 9.30 | 123 | 269995 | 15417 | 64213197 |
Granulomatous rosacea | 20.29 | 9.30 | 12 | 270106 | 197 | 64228417 |
Hepatic haematoma | 20.29 | 9.30 | 21 | 270097 | 807 | 64227807 |
Drug interaction | 20.24 | 9.30 | 1770 | 268348 | 360313 | 63868301 |
Bicytopenia | 20.20 | 9.30 | 46 | 270072 | 3576 | 64225038 |
Rectosigmoid cancer | 20.19 | 9.30 | 13 | 270105 | 250 | 64228364 |
Febrile neutropenia | 20.15 | 9.30 | 615 | 269503 | 187042 | 64041572 |
Renal cyst | 20.14 | 9.30 | 105 | 270013 | 12465 | 64216149 |
Dyspepsia | 20.08 | 9.30 | 459 | 269659 | 79853 | 64148761 |
Arterial occlusive disease | 20.05 | 9.30 | 70 | 270048 | 6963 | 64221651 |
Muscle spasticity | 20.03 | 9.30 | 129 | 269989 | 16540 | 64212074 |
Anxiety | 19.97 | 9.30 | 1039 | 269079 | 201610 | 64027004 |
Live birth | 19.97 | 9.30 | 11 | 270107 | 11193 | 64217421 |
Therapy partial responder | 19.86 | 9.30 | 9 | 270109 | 10239 | 64218375 |
Immune reconstitution inflammatory syndrome | 19.80 | 9.30 | 14 | 270104 | 12456 | 64216158 |
Sudden death | 19.71 | 9.30 | 148 | 269970 | 19948 | 64208666 |
Loss of personal independence in daily activities | 19.67 | 9.30 | 201 | 269917 | 72253 | 64156361 |
Rebound acid hypersecretion | 19.65 | 9.30 | 9 | 270109 | 84 | 64228530 |
Palpitations | 19.65 | 9.30 | 575 | 269543 | 103913 | 64124701 |
Campylobacter colitis | 19.47 | 9.30 | 7 | 270111 | 32 | 64228582 |
Heat stroke | 19.29 | 9.30 | 27 | 270091 | 1428 | 64227186 |
Gastric disorder | 19.24 | 9.30 | 197 | 269921 | 29000 | 64199614 |
Drug dependence | 19.24 | 9.30 | 73 | 270045 | 33239 | 64195375 |
Bunion operation | 19.23 | 9.30 | 20 | 270098 | 773 | 64227841 |
Electrocardiogram Q wave abnormal | 19.23 | 9.30 | 15 | 270103 | 395 | 64228219 |
Muscle contractions involuntary | 19.23 | 9.30 | 42 | 270076 | 3175 | 64225439 |
Scleritis | 19.20 | 9.30 | 40 | 270078 | 2926 | 64225688 |
Stomatitis | 19.17 | 9.30 | 333 | 269785 | 109272 | 64119342 |
Acute pulmonary oedema | 19.17 | 9.30 | 105 | 270013 | 12704 | 64215910 |
Adverse drug reaction | 18.98 | 9.30 | 112 | 270006 | 45352 | 64183262 |
Bradypnoea | 18.94 | 9.30 | 56 | 270062 | 5103 | 64223511 |
Acute graft versus host disease in skin | 18.93 | 9.30 | 3 | 270115 | 6852 | 64221762 |
Hepatic encephalopathy | 18.92 | 9.30 | 152 | 269966 | 20914 | 64207700 |
Gastric antral vascular ectasia | 18.92 | 9.30 | 20 | 270098 | 788 | 64227826 |
Intentional self-injury | 18.54 | 9.30 | 61 | 270057 | 28983 | 64199631 |
Ventricular hypokinesia | 18.53 | 9.30 | 73 | 270045 | 7696 | 64220918 |
Mesenteric panniculitis | 18.45 | 9.30 | 12 | 270106 | 235 | 64228379 |
Genital infection female | 18.42 | 9.30 | 8 | 270110 | 65 | 64228549 |
Haematoma | 18.40 | 9.30 | 284 | 269834 | 45966 | 64182648 |
Renal tubular disorder | 18.31 | 9.30 | 61 | 270057 | 5926 | 64222688 |
Radiation pneumonitis | 18.27 | 9.30 | 42 | 270076 | 3286 | 64225328 |
Ocular myasthenia | 18.17 | 9.30 | 14 | 270104 | 362 | 64228252 |
Dystonia | 18.09 | 9.30 | 32 | 270086 | 18833 | 64209781 |
Stevens-Johnson syndrome | 17.98 | 9.30 | 221 | 269897 | 34028 | 64194586 |
Angina bullosa haemorrhagica | 17.86 | 9.30 | 11 | 270107 | 195 | 64228419 |
Vitamin B12 deficiency | 17.86 | 9.30 | 57 | 270061 | 5415 | 64223199 |
Arthralgia | 17.83 | 9.30 | 1602 | 268516 | 440658 | 63787956 |
Phaeochromocytoma malignant | 17.72 | 9.30 | 8 | 270110 | 72 | 64228542 |
Nephritic syndrome | 17.64 | 9.30 | 12 | 270106 | 254 | 64228360 |
Venoocclusive liver disease | 17.61 | 9.30 | 10 | 270108 | 10005 | 64218609 |
Dry mouth | 17.58 | 9.30 | 353 | 269765 | 60065 | 64168549 |
Brain scan abnormal | 17.50 | 9.30 | 23 | 270095 | 1145 | 64227469 |
Thrombocytopenic purpura | 17.46 | 9.30 | 32 | 270086 | 2130 | 64226484 |
Hyperphosphatasaemia | 17.44 | 9.30 | 8 | 270110 | 75 | 64228539 |
Tachycardia | 17.36 | 9.30 | 485 | 269633 | 149094 | 64079520 |
Type I hypersensitivity | 17.35 | 9.30 | 43 | 270075 | 3531 | 64225083 |
Mucosal inflammation | 17.24 | 9.30 | 173 | 269945 | 62411 | 64166203 |
Pulmonary arterial hypertension | 17.12 | 9.30 | 172 | 269946 | 25195 | 64203419 |
Cardiac aneurysm | 17.06 | 9.30 | 24 | 270094 | 1275 | 64227339 |
Eye injury | 17.03 | 9.30 | 27 | 270091 | 1597 | 64227017 |
Hyperkinetic heart syndrome | 16.92 | 9.30 | 9 | 270109 | 119 | 64228495 |
Ischaemic stroke | 16.85 | 9.30 | 191 | 269927 | 28844 | 64199770 |
Occupational exposure to air contaminants | 16.79 | 9.30 | 9 | 270109 | 121 | 64228493 |
Chronic graft versus host disease | 16.77 | 9.30 | 3 | 270115 | 6273 | 64222341 |
Pre-eclampsia | 16.61 | 9.30 | 3 | 270115 | 6228 | 64222386 |
Gastroenteritis eosinophilic | 16.58 | 9.30 | 11 | 270107 | 223 | 64228391 |
Nephropathy toxic | 16.53 | 9.30 | 30 | 270088 | 17484 | 64211130 |
Rash scarlatiniform | 16.49 | 9.30 | 11 | 270107 | 225 | 64228389 |
Angina unstable | 16.37 | 9.30 | 116 | 270002 | 15351 | 64213263 |
Cardiorenal syndrome | 16.28 | 9.30 | 23 | 270095 | 1227 | 64227387 |
Suicide attempt | 16.13 | 9.30 | 205 | 269913 | 70802 | 64157812 |
Prescription form tampering | 16.08 | 9.30 | 13 | 270105 | 361 | 64228253 |
Drug eruption | 15.98 | 9.30 | 226 | 269892 | 35910 | 64192704 |
Transient ischaemic attack | 15.96 | 9.30 | 267 | 269851 | 43915 | 64184699 |
Fall | 15.94 | 9.30 | 1986 | 268132 | 414840 | 63813774 |
Premature labour | 15.89 | 9.30 | 6 | 270112 | 7614 | 64221000 |
Immunodeficiency | 15.78 | 9.30 | 27 | 270091 | 16097 | 64212517 |
Dialysis | 15.70 | 9.30 | 123 | 269995 | 16797 | 64211817 |
Deformity | 15.70 | 9.30 | 60 | 270058 | 6237 | 64222377 |
CSF volume increased | 15.64 | 9.30 | 6 | 270112 | 34 | 64228580 |
Hypotension | 15.64 | 9.30 | 1378 | 268740 | 379596 | 63849018 |
Nausea | 15.47 | 9.30 | 3613 | 266505 | 782187 | 63446427 |
Drug tolerance decreased | 15.47 | 9.30 | 5 | 270113 | 6993 | 64221621 |
Overdose | 15.44 | 9.30 | 530 | 269588 | 159036 | 64069578 |
Fear of injection | 15.43 | 9.30 | 3 | 270115 | 5909 | 64222705 |
Memory impairment | 15.41 | 9.30 | 259 | 269859 | 85423 | 64143191 |
Carotid artery stenosis | 15.36 | 9.30 | 70 | 270048 | 7871 | 64220743 |
Substance abuse | 15.33 | 9.30 | 10 | 270108 | 9282 | 64219332 |
Eosinophilic fasciitis | 15.28 | 9.30 | 10 | 270108 | 198 | 64228416 |
Infection | 15.24 | 9.30 | 626 | 269492 | 184254 | 64044360 |
Purging | 15.22 | 9.30 | 6 | 270112 | 37 | 64228577 |
Gastrointestinal motility disorder | 15.16 | 9.30 | 52 | 270066 | 5127 | 64223487 |
Hyperlipidaemia | 15.13 | 9.30 | 155 | 269963 | 22821 | 64205793 |
Nerve degeneration | 15.12 | 9.30 | 11 | 270107 | 260 | 64228354 |
Schizophreniform disorder | 15.10 | 9.30 | 9 | 270109 | 150 | 64228464 |
Haematoma muscle | 15.06 | 9.30 | 27 | 270091 | 1766 | 64226848 |
Duodenitis | 15.01 | 9.30 | 62 | 270056 | 6679 | 64221935 |
Systolic dysfunction | 14.99 | 9.30 | 38 | 270080 | 3164 | 64225450 |
Escherichia pyelonephritis | 14.98 | 9.30 | 14 | 270104 | 474 | 64228140 |
No adverse event | 14.98 | 9.30 | 65 | 270053 | 28496 | 64200118 |
Synovial cyst | 14.95 | 9.30 | 68 | 270050 | 7639 | 64220975 |
Diverticulum oesophageal | 14.95 | 9.30 | 9 | 270109 | 153 | 64228461 |
Microcytic anaemia | 14.85 | 9.30 | 48 | 270070 | 4590 | 64224024 |
Heart rate decreased | 14.85 | 9.30 | 153 | 269965 | 54914 | 64173700 |
Clinically isolated syndrome | 14.84 | 9.30 | 5 | 270113 | 18 | 64228596 |
Injection site haemorrhage | 14.81 | 9.30 | 52 | 270066 | 24226 | 64204388 |
Eyelid oedema | 14.74 | 9.30 | 95 | 270023 | 12184 | 64216430 |
Pruritus | 14.74 | 9.30 | 1509 | 268609 | 310891 | 63917723 |
Coronary artery stenosis | 14.73 | 9.30 | 89 | 270029 | 11159 | 64217455 |
Hepatic function abnormal | 14.69 | 9.30 | 363 | 269755 | 63950 | 64164664 |
Rhinitis | 14.63 | 9.30 | 86 | 270032 | 10679 | 64217935 |
Hypocapnia | 14.52 | 9.30 | 15 | 270103 | 575 | 64228039 |
High frequency ablation | 14.52 | 9.30 | 11 | 270107 | 277 | 64228337 |
Oesophageal adenocarcinoma | 14.50 | 9.30 | 17 | 270101 | 752 | 64227862 |
Anticoagulation drug level increased | 14.48 | 9.30 | 16 | 270102 | 663 | 64227951 |
Renal tubular necrosis | 14.48 | 9.30 | 149 | 269969 | 21961 | 64206653 |
Transplant dysfunction | 14.46 | 9.30 | 5 | 270113 | 6703 | 64221911 |
Cerebellar haematoma | 14.42 | 9.30 | 15 | 270103 | 580 | 64228034 |
Thymus disorder | 14.40 | 9.30 | 10 | 270108 | 219 | 64228395 |
Sedation | 14.36 | 9.30 | 108 | 270010 | 41354 | 64187260 |
Exposure to toxic agent | 14.34 | 9.30 | 4 | 270114 | 6155 | 64222459 |
Impaired work ability | 14.32 | 9.30 | 111 | 270007 | 15108 | 64213506 |
Hyperkaliuria | 14.31 | 9.30 | 9 | 270109 | 166 | 64228448 |
IIIrd nerve paresis | 14.21 | 9.30 | 9 | 270109 | 168 | 64228446 |
Contusion | 14.14 | 9.30 | 366 | 269752 | 113599 | 64115015 |
Therapy cessation | 14.12 | 9.30 | 79 | 270039 | 32410 | 64196204 |
Granuloma skin | 14.04 | 9.30 | 4 | 270114 | 6070 | 64222544 |
Haemorrhage intracranial | 14.01 | 9.30 | 52 | 270066 | 23832 | 64204782 |
Renal disorder | 14.00 | 9.30 | 217 | 269901 | 35148 | 64193466 |
Septic shock | 13.95 | 9.30 | 557 | 269561 | 104880 | 64123734 |
Occupational exposure to product | 13.95 | 9.30 | 15 | 270103 | 603 | 64228011 |
Small cell carcinoma | 13.87 | 9.30 | 11 | 270107 | 297 | 64228317 |
Localised infection | 13.85 | 9.30 | 72 | 270046 | 30089 | 64198525 |
Cutaneous lupus erythematosus | 13.80 | 9.30 | 33 | 270085 | 2649 | 64225965 |
Gallbladder hypofunction | 13.70 | 9.30 | 13 | 270105 | 449 | 64228165 |
Sinus congestion | 13.65 | 9.30 | 111 | 270007 | 15328 | 64213286 |
Electric shock | 13.57 | 9.30 | 20 | 270098 | 1109 | 64227505 |
Pneumobilia | 13.54 | 9.30 | 9 | 270109 | 183 | 64228431 |
Eructation | 13.52 | 9.30 | 75 | 270043 | 9116 | 64219498 |
Vitreous detachment | 13.51 | 9.30 | 27 | 270091 | 1917 | 64226697 |
Cholecystectomy | 13.50 | 9.30 | 68 | 270050 | 7964 | 64220650 |
Psychotic disorder | 13.49 | 9.30 | 87 | 270031 | 34491 | 64194123 |
Tooth demineralisation | 13.44 | 9.30 | 3 | 270115 | 0 | 64228614 |
Flatulence | 13.42 | 9.30 | 217 | 269901 | 35449 | 64193165 |
Thrombophlebitis | 13.38 | 9.30 | 53 | 270065 | 5601 | 64223013 |
Graft versus host disease in skin | 13.36 | 9.30 | 3 | 270115 | 5344 | 64223270 |
Nephritis allergic | 13.36 | 9.30 | 15 | 270103 | 633 | 64227981 |
Hepatocellular carcinoma | 13.33 | 9.30 | 70 | 270048 | 8333 | 64220281 |
Cardiotoxicity | 13.31 | 9.30 | 14 | 270104 | 10260 | 64218354 |
Oedema peripheral | 13.31 | 9.30 | 1038 | 269080 | 209279 | 64019335 |
Crepitations | 13.30 | 9.30 | 67 | 270051 | 7848 | 64220766 |
Tongue oedema | 13.26 | 9.30 | 55 | 270063 | 5935 | 64222679 |
Pancreatitis chronic | 13.24 | 9.30 | 39 | 270079 | 3547 | 64225067 |
Disability | 13.23 | 9.30 | 19 | 270099 | 12153 | 64216461 |
Wrong technique in product usage process | 13.17 | 9.30 | 192 | 269926 | 64782 | 64163832 |
Pancreatic neuroendocrine tumour | 13.10 | 9.30 | 13 | 270105 | 475 | 64228139 |
Infusion site scar | 13.09 | 9.30 | 10 | 270108 | 255 | 64228359 |
Subdural haematoma | 13.03 | 9.30 | 177 | 269941 | 27877 | 64200737 |
Aspergillus infection | 12.98 | 9.30 | 31 | 270087 | 16348 | 64212266 |
Transplant rejection | 12.96 | 9.30 | 34 | 270084 | 17367 | 64211247 |
Bile duct stone | 12.88 | 9.30 | 48 | 270070 | 4930 | 64223684 |
Oesophagitis | 12.88 | 9.30 | 143 | 269975 | 21487 | 64207127 |
Supraventricular extrasystoles | 12.85 | 9.30 | 54 | 270064 | 5861 | 64222753 |
Dermatitis exfoliative generalised | 12.85 | 9.30 | 54 | 270064 | 5862 | 64222752 |
Ejection fraction abnormal | 12.81 | 9.30 | 22 | 270096 | 1391 | 64227223 |
Panniculitis | 12.79 | 9.30 | 11 | 270107 | 8868 | 64219746 |
Melaena | 12.76 | 9.30 | 304 | 269814 | 53244 | 64175370 |
Bronchopneumopathy | 12.70 | 9.30 | 14 | 270104 | 579 | 64228035 |
Fixed eruption | 12.69 | 9.30 | 28 | 270090 | 2131 | 64226483 |
Uveal melanoma | 12.68 | 9.30 | 4 | 270114 | 11 | 64228603 |
Drug specific antibody present | 12.67 | 9.30 | 3 | 270115 | 5151 | 64223463 |
Acute hepatitis B | 12.66 | 9.30 | 12 | 270106 | 414 | 64228200 |
Liver function test increased | 12.56 | 9.30 | 77 | 270041 | 30893 | 64197721 |
Kidney infection | 12.55 | 9.30 | 122 | 269996 | 17716 | 64210898 |
Pleuritic pain | 12.54 | 9.30 | 67 | 270051 | 8029 | 64220585 |
Tubulointerstitial nephritis and uveitis syndrome | 12.48 | 9.30 | 10 | 270108 | 274 | 64228340 |
Renal impairment | 12.44 | 9.30 | 688 | 269430 | 134329 | 64094285 |
Prurigo | 12.44 | 9.30 | 20 | 270098 | 1197 | 64227417 |
Normal newborn | 12.44 | 9.30 | 4 | 270114 | 5613 | 64223001 |
Ventricular enlargement | 12.34 | 9.30 | 13 | 270105 | 510 | 64228104 |
Blood thyroid stimulating hormone increased | 12.31 | 9.30 | 64 | 270054 | 7590 | 64221024 |
Diverticulum | 12.27 | 9.30 | 96 | 270022 | 13102 | 64215512 |
Lethargy | 12.23 | 9.30 | 222 | 269896 | 72372 | 64156242 |
Food interaction | 12.22 | 9.30 | 22 | 270096 | 1444 | 64227170 |
Cardio-respiratory arrest | 12.20 | 9.30 | 316 | 269802 | 98077 | 64130537 |
Nerve injury | 12.18 | 9.30 | 64 | 270054 | 7621 | 64220993 |
Dermatophytosis of nail | 12.15 | 9.30 | 8 | 270110 | 160 | 64228454 |
Circumoral oedema | 12.15 | 9.30 | 10 | 270108 | 285 | 64228329 |
Seizure | 12.13 | 9.30 | 573 | 269545 | 166319 | 64062295 |
Inappropriate schedule of product administration | 12.09 | 9.30 | 294 | 269824 | 91992 | 64136622 |
Device use error | 12.05 | 9.30 | 6 | 270112 | 6465 | 64222149 |
Myoglobinaemia | 12.05 | 9.30 | 7 | 270111 | 111 | 64228503 |
Cyst | 12.04 | 9.30 | 89 | 270029 | 11938 | 64216676 |
Antinuclear antibody positive | 12.02 | 9.30 | 55 | 270063 | 6195 | 64222419 |
Cerebral infarction | 12.01 | 9.30 | 240 | 269878 | 40804 | 64187810 |
Immune-mediated hepatic disorder | 12.00 | 9.30 | 13 | 270105 | 527 | 64228087 |
Hypoplastic anaemia | 11.96 | 9.30 | 4 | 270114 | 14 | 64228600 |
Cataract | 11.90 | 9.30 | 290 | 269828 | 50972 | 64177642 |
Graft versus host disease | 11.88 | 9.30 | 25 | 270093 | 13788 | 64214826 |
Cardiac murmur functional | 11.80 | 9.30 | 5 | 270113 | 38 | 64228576 |
Respiratory syncytial virus infection | 11.75 | 9.30 | 8 | 270110 | 7260 | 64221354 |
Placental calcification | 11.75 | 9.30 | 4 | 270114 | 15 | 64228599 |
Essential hypertension | 11.75 | 9.30 | 48 | 270070 | 5146 | 64223468 |
Hyperuricaemia | 11.72 | 9.30 | 78 | 270040 | 10113 | 64218501 |
Renal infarct | 11.69 | 9.30 | 29 | 270089 | 2382 | 64226232 |
Gastric ulcer haemorrhage | 11.68 | 9.30 | 66 | 270052 | 8077 | 64220537 |
Cerebral artery thrombosis | 11.65 | 9.30 | 18 | 270100 | 1041 | 64227573 |
Intestinal infarction | 11.57 | 9.30 | 20 | 270098 | 1271 | 64227343 |
Parkinsonism | 11.55 | 9.30 | 27 | 270091 | 14346 | 64214268 |
Vulvovaginal burning sensation | 11.54 | 9.30 | 19 | 270099 | 1160 | 64227454 |
Blood lactic acid increased | 11.54 | 9.30 | 16 | 270102 | 10385 | 64218229 |
Unintentional medical device removal | 11.45 | 9.30 | 7 | 270111 | 6727 | 64221887 |
Bursitis | 11.44 | 9.30 | 139 | 269979 | 21346 | 64207268 |
Renal atrophy | 11.43 | 9.30 | 23 | 270095 | 1641 | 64226973 |
Anaemia folate deficiency | 11.41 | 9.30 | 9 | 270109 | 241 | 64228373 |
Haemorrhoids | 11.38 | 9.30 | 152 | 269966 | 23849 | 64204765 |
Therapeutic product effect incomplete | 11.38 | 9.30 | 338 | 269780 | 103144 | 64125470 |
Platelet adhesiveness decreased | 11.37 | 9.30 | 3 | 270115 | 3 | 64228611 |
Neutrophilia | 11.32 | 9.30 | 7 | 270111 | 6687 | 64221927 |
Xerosis | 11.31 | 9.30 | 17 | 270101 | 960 | 64227654 |
Creatinine renal clearance abnormal | 11.27 | 9.30 | 12 | 270106 | 477 | 64228137 |
Tumour associated fever | 11.25 | 9.30 | 13 | 270105 | 566 | 64228048 |
Epstein-Barr virus infection | 11.25 | 9.30 | 22 | 270096 | 12466 | 64216148 |
Cytomegalovirus infection reactivation | 11.24 | 9.30 | 5 | 270113 | 5751 | 64222863 |
Prothrombin time ratio decreased | 11.24 | 9.30 | 15 | 270103 | 758 | 64227856 |
Dehydration | 11.23 | 9.30 | 1054 | 269064 | 215709 | 64012905 |
Traumatic haematoma | 11.23 | 9.30 | 25 | 270093 | 1915 | 64226699 |
Asthma | 11.22 | 9.30 | 497 | 269621 | 94728 | 64133886 |
Coronary artery disease | 11.20 | 9.30 | 332 | 269786 | 60101 | 64168513 |
Carotid arteriosclerosis | 11.15 | 9.30 | 26 | 270092 | 2053 | 64226561 |
Toxic epidermal necrolysis | 11.10 | 9.30 | 218 | 269900 | 36948 | 64191666 |
Cognitive disorder | 11.09 | 9.30 | 163 | 269955 | 54924 | 64173690 |
Hypoparathyroidism | 11.08 | 9.30 | 16 | 270102 | 871 | 64227743 |
Chest expansion decreased | 11.07 | 9.30 | 8 | 270110 | 187 | 64228427 |
Vulval disorder | 11.06 | 9.30 | 12 | 270106 | 487 | 64228127 |
Injection site warmth | 11.05 | 9.30 | 25 | 270093 | 13437 | 64215177 |
Hyponatraemic seizure | 11.02 | 9.30 | 12 | 270106 | 489 | 64228125 |
Cytomegalovirus infection | 11.02 | 9.30 | 101 | 270017 | 37098 | 64191516 |
Unevaluable event | 11.01 | 9.30 | 147 | 269971 | 50342 | 64178272 |
Device issue | 11.01 | 9.30 | 53 | 270065 | 22595 | 64206019 |
Campylobacter gastroenteritis | 10.95 | 9.30 | 18 | 270100 | 1098 | 64227516 |
Dermatosis | 10.93 | 9.30 | 12 | 270106 | 494 | 64228120 |
Regurgitation | 10.90 | 9.30 | 26 | 270092 | 2083 | 64226531 |
Renal hypertension | 10.89 | 9.30 | 8 | 270110 | 192 | 64228422 |
Enterocolitis haemorrhagic | 10.88 | 9.30 | 25 | 270093 | 1955 | 64226659 |
Creatinine renal clearance decreased | 10.87 | 9.30 | 28 | 270090 | 14393 | 64214221 |
Oesophageal hypomotility | 10.86 | 9.30 | 6 | 270112 | 86 | 64228528 |
Enterochromaffin cell hyperplasia | 10.86 | 9.30 | 6 | 270112 | 86 | 64228528 |
Duodenal polyp | 10.83 | 9.30 | 9 | 270109 | 260 | 64228354 |
Purple glove syndrome | 10.80 | 9.30 | 9 | 270109 | 261 | 64228353 |
Brief psychotic disorder with marked stressors | 10.77 | 9.30 | 9 | 270109 | 262 | 64228352 |
Cholecystitis acute | 10.77 | 9.30 | 83 | 270035 | 11277 | 64217337 |
Liver disorder | 10.69 | 9.30 | 296 | 269822 | 53055 | 64175559 |
Abdominal strangulated hernia | 10.62 | 9.30 | 6 | 270112 | 90 | 64228524 |
Cardiothoracic ratio increased | 10.62 | 9.30 | 5 | 270113 | 50 | 64228564 |
Pleurisy | 10.61 | 9.30 | 71 | 270047 | 9220 | 64219394 |
Alanine aminotransferase abnormal | 10.59 | 9.30 | 8 | 270110 | 6880 | 64221734 |
Colitis ischaemic | 10.57 | 9.30 | 94 | 270024 | 13320 | 64215294 |
Gait inability | 10.51 | 9.30 | 120 | 269998 | 42248 | 64186366 |
Biliary tract disorder | 10.48 | 9.30 | 20 | 270098 | 1373 | 64227241 |
Lipase increased | 10.38 | 9.30 | 99 | 270019 | 14303 | 64214311 |
Complication of device insertion | 10.36 | 9.30 | 4 | 270114 | 5008 | 64223606 |
Muscle swelling | 10.36 | 9.30 | 14 | 270104 | 716 | 64227898 |
Subacute cutaneous lupus erythematosus | 10.32 | 9.30 | 32 | 270086 | 2993 | 64225621 |
Withdrawal syndrome | 10.28 | 9.30 | 57 | 270061 | 23435 | 64205179 |
Hallucination, olfactory | 10.19 | 9.30 | 11 | 270107 | 444 | 64228170 |
Vertigo | 10.09 | 9.30 | 321 | 269797 | 58690 | 64169924 |
Abnormal behaviour | 10.09 | 9.30 | 91 | 270027 | 33531 | 64195083 |
Arterial spasm | 10.02 | 9.30 | 7 | 270111 | 155 | 64228459 |
Eosinophilic oesophagitis | 10.01 | 9.30 | 11 | 270107 | 453 | 64228161 |
Adrenocorticotropic hormone deficiency | 10.00 | 9.30 | 15 | 270103 | 845 | 64227769 |
Idiosyncratic drug reaction | 10.00 | 9.30 | 18 | 270100 | 1181 | 64227433 |
Carbohydrate antigen 19-9 increased | 9.99 | 9.30 | 10 | 270108 | 369 | 64228245 |
Coagulation factor decreased | 9.98 | 9.30 | 7 | 270111 | 156 | 64228458 |
Teeth brittle | 9.97 | 9.30 | 11 | 270107 | 455 | 64228159 |
Vulval oedema | 9.97 | 9.30 | 4 | 270114 | 26 | 64228588 |
Nephrosclerosis | 9.95 | 9.30 | 21 | 270097 | 1550 | 64227064 |
Herpes simplex test positive | 9.95 | 9.30 | 10 | 270108 | 371 | 64228243 |
Blood pressure fluctuation | 9.92 | 9.30 | 155 | 269963 | 51716 | 64176898 |
Dyshidrotic eczema | 9.90 | 9.30 | 12 | 270106 | 550 | 64228064 |
Therapeutic embolisation | 9.88 | 9.30 | 11 | 270107 | 460 | 64228154 |
Enterocolitis | 9.88 | 9.30 | 85 | 270033 | 11933 | 64216681 |
Brucellosis | 9.86 | 9.30 | 6 | 270112 | 104 | 64228510 |
Laparoscopy | 9.86 | 9.30 | 3 | 270115 | 7 | 64228607 |
Impaired healing | 9.86 | 9.30 | 186 | 269932 | 60287 | 64168327 |
Gastric cancer stage 0 | 9.84 | 9.30 | 4 | 270114 | 27 | 64228587 |
Cytomegalovirus viraemia | 9.82 | 9.30 | 19 | 270099 | 10809 | 64217805 |
Neurosis | 9.71 | 9.30 | 10 | 270108 | 382 | 64228232 |
Vulvovaginal inflammation | 9.71 | 9.30 | 11 | 270107 | 469 | 64228145 |
Bronchopulmonary aspergillosis | 9.67 | 9.30 | 44 | 270074 | 19041 | 64209573 |
Cardiac disorder | 9.64 | 9.30 | 304 | 269814 | 55512 | 64173102 |
Hepatobiliary scan abnormal | 9.61 | 9.30 | 5 | 270113 | 63 | 64228551 |
Tongue pruritus | 9.56 | 9.30 | 11 | 270107 | 477 | 64228137 |
Cellulitis | 9.54 | 9.30 | 309 | 269809 | 93348 | 64135266 |
Conjunctival ulcer | 9.54 | 9.30 | 5 | 270113 | 64 | 64228550 |
Shock haemorrhagic | 9.54 | 9.30 | 110 | 270008 | 16681 | 64211933 |
Nocardiosis | 9.53 | 9.30 | 4 | 270114 | 4763 | 64223851 |
Burning sensation | 9.52 | 9.30 | 274 | 269844 | 49390 | 64179224 |
Obesity | 9.49 | 9.30 | 49 | 270069 | 20513 | 64208101 |
Brain injury | 9.47 | 9.30 | 17 | 270101 | 9948 | 64218666 |
Tooth disorder | 9.47 | 9.30 | 139 | 269979 | 22263 | 64206351 |
Basal cell carcinoma | 9.46 | 9.30 | 83 | 270035 | 30755 | 64197859 |
Faecal vomiting | 9.34 | 9.30 | 16 | 270102 | 1009 | 64227605 |
False negative investigation result | 9.34 | 9.30 | 8 | 270110 | 241 | 64228373 |
Eosinophilic pneumonia | 9.34 | 9.30 | 41 | 270077 | 4536 | 64224078 |
Mesenteric artery stenosis | 9.32 | 9.30 | 3 | 270115 | 9 | 64228605 |
None
Source | Code | Description |
---|---|---|
ATC | A02BC05 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Proton pump inhibitors |
ATC | A02BD06 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | M01AE52 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives |
FDA MoA | N0000000147 | Proton Pump Inhibitors |
FDA EPC | N0000175525 | Proton Pump Inhibitor |
MeSH PA | D000897 | Anti-Ulcer Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D054328 | Proton Pump Inhibitors |
CHEBI has role | CHEBI:35623 | anticonvulsants |
CHEBI has role | CHEBI:49200 | proton pump inhibitors |
CHEBI has role | CHEBI:49201 | anti-ulcer drugs |
CHEBI has role | CHEBI:50183 | P450 inhibitors |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
FDA MoA | N0000182140 | Cytochrome P450 2C19 Inhibitors |
CHEBI has role | CHEBI:37956 | antihistamines |
CHEBI has role | CHEBI:38623 | monoamine oxidase inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Peptic ulcer | indication | 13200003 | DOID:750 |
Erosive esophagitis | indication | 40719004 | |
Zollinger-Ellison syndrome | indication | 53132006 | DOID:0050782 |
Peptic reflux disease | indication | 57643001 | |
Gastroesophageal reflux disease | indication | 235595009 | DOID:8534 |
Prevention of NSAID-Induced Gastric Ulcer | indication | ||
Osteoarthritis in Patients at High Ulcer Risk | indication | ||
Rheumatoid Arthritis in Patient at High Ulcer Risk | indication | ||
Pathological Gastric Hypersecretory Condition | indication | ||
Duodenal Ulcer due to H. Pylori | indication | ||
Maintenance of Healing Erosive Esophagitis | indication | ||
Upper gastrointestinal hemorrhage | off-label use | 37372002 | |
Hepatic failure | contraindication | 59927004 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Atrophic gastritis | contraindication | 84568007 | DOID:8929 |
Fracture of bone | contraindication | 125605004 | |
Hypomagnesemia | contraindication | 190855004 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.71 | acidic |
pKa2 | 4.44 | Basic |
pKa3 | 2.53 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 20MG BASE;375MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 8852636 | May 31, 2022 | RELIEF OF SIGNS AND SYMPTOMS OF ARTHRITIS AND RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER |
EQ 20MG BASE;375MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 8858996 | May 31, 2022 | RELIEF OF SIGNS AND SYMPTOMS OF ARTHRITIS AND RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER |
EQ 20MG BASE;375MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 9161920 | May 31, 2022 | RISK-REDUCTION OF NSAID GASTRIC ULCER IN PATIENTS REQUIRING CHRONIC NSAID TREATMENT |
EQ 20MG BASE;375MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 9198888 | May 31, 2022 | RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS REQUIRING NSAID TREATMENT |
EQ 20MG BASE;500MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 8852636 | May 31, 2022 | RELIEF OF SIGNS AND SYMPTOMS OF ARTHRITIS AND RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER |
EQ 20MG BASE;500MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 8858996 | May 31, 2022 | RELIEF OF SIGNS AND SYMPTOMS OF ARTHRITIS AND RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER |
EQ 20MG BASE;500MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 9161920 | May 31, 2022 | RISK-REDUCTION OF NSAID GASTRIC ULCER IN PATIENTS REQUIRING CHRONIC NSAID TREATMENT |
EQ 20MG BASE;500MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 9198888 | May 31, 2022 | RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS REQUIRING NSAID TREATMENT |
EQ 20MG BASE;375MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 9393208 | Sept. 3, 2029 | RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS REQUIRING NSAID TREATMENT |
EQ 20MG BASE;500MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 9393208 | Sept. 3, 2029 | RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS REQUIRING NSAID TREATMENT |
EQ 20MG BASE;500MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 9220698 | March 10, 2031 | RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS REQUIRING NSAID TREATMENT |
EQ 20MG BASE;375MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 8945621 | Oct. 17, 2031 | RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCERS IN PATIENTS ALSO TAKING LOW DOSE ASPIRIN |
EQ 20MG BASE;500MG | VIMOVO | HORIZON | N022511 | April 30, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 8945621 | Oct. 17, 2031 | RISK-REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCERS IN PATIENTS ALSO TAKING LOW DOSE ASPIRIN |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Potassium-transporting ATPase | Transporter | INHIBITOR | CHEMBL | CHEMBL |
ID | Source |
---|---|
4021259 | VUID |
N0000189434 | NUI |
D01984 | KEGG_DRUG |
217087-10-0 | SECONDARY_CAS_RN |
217087-09-7 | SECONDARY_CAS_RN |
161796-78-7 | SECONDARY_CAS_RN |
934714-36-0 | SECONDARY_CAS_RN |
4019439 | VANDF |
4021259 | VANDF |
4021260 | VANDF |
4025229 | VANDF |
4032661 | VANDF |
C0937846 | UMLSCUI |
CHEBI:50275 | CHEBI |
CHEBI:7772 | CHEBI |
1C6 | PDB_CHEM_ID |
CHEMBL1201320 | ChEMBL_ID |
DB00736 | DRUGBANK_ID |
CHEMBL2146133 | ChEMBL_ID |
CHEMBL1200470 | ChEMBL_ID |
D064098 | MESH_DESCRIPTOR_UI |
4594 | PUBCHEM_CID |
5488 | IUPHAR_LIGAND_ID |
7766 | INN_ID |
N3PA6559FT | UNII |
DB00338 | DRUGBANK_ID |
1294569 | RXNORM |
15914 | MMSL |
19233 | MMSL |
205449 | MMSL |
211151 | MMSL |
232889 | MMSL |
29630 | MMSL |
45807 | MMSL |
5201 | MMSL |
d00325 | MMSL |
d04749 | MMSL |
003476 | NDDF |
008590 | NDDF |
008918 | NDDF |
008919 | NDDF |
015173 | NDDF |
129489006 | SNOMEDCT_US |
25673006 | SNOMEDCT_US |
317331009 | SNOMEDCT_US |
387137007 | SNOMEDCT_US |
396047003 | SNOMEDCT_US |
426956003 | SNOMEDCT_US |
725855001 | SNOMEDCT_US |
C0028978 | UMLSCUI |
CHEMBL2146140 | ChEMBL_ID |
D009853 | MESH_DESCRIPTOR_UI |
5081 | INN_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Esomeprazole Magnesium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-6450 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 28 sections |
Esomeprazole Magnesium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-6451 | CAPSULE, DELAYED RELEASE | 40 mg | ORAL | ANDA | 28 sections |
good sense esomeprazole magnesium | HUMAN OTC DRUG LABEL | 1 | 0113-0651 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 15 sections |
basic care esomeprazole magnesium | HUMAN OTC DRUG LABEL | 1 | 0113-0732 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 15 sections |
Good Sense Esomeprazole Magnesium | HUMAN OTC DRUG LABEL | 1 | 0113-0898 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 15 sections |
Esomeprazole magnesium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-0382 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | NDA authorized generic | 28 sections |
Esomeprazole magnesium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-0384 | CAPSULE, DELAYED RELEASE | 40 mg | ORAL | NDA authorized generic | 28 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4010 | GRANULE, DELAYED RELEASE | 10 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4010 | GRANULE, DELAYED RELEASE | 10 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4020 | GRANULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4020 | GRANULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4025 | GRANULE, DELAYED RELEASE | 2.50 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4025 | GRANULE, DELAYED RELEASE | 2.50 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4040 | GRANULE, DELAYED RELEASE | 40 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4040 | GRANULE, DELAYED RELEASE | 40 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4050 | GRANULE, DELAYED RELEASE | 5 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-4050 | GRANULE, DELAYED RELEASE | 5 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-5020 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-5020 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-5040 | CAPSULE, DELAYED RELEASE | 40 mg | ORAL | NDA | 27 sections |
NEXIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-5040 | CAPSULE, DELAYED RELEASE | 40 mg | ORAL | NDA | 27 sections |
NEXIUMI.V. | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-6040 | INJECTION | 40 mg | INTRAVENOUS | NDA | 28 sections |
NEXIUMI.V. | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-6040 | INJECTION | 40 mg | INTRAVENOUS | NDA | 28 sections |
Esomeprazole Magnesium | Human OTC Drug Label | 1 | 0363-0508 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 12 sections |
Esomeprazole Magnesium | HUMAN OTC DRUG LABEL | 1 | 0363-1699 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 15 sections |
esomeprazole magnesium | HUMAN OTC DRUG LABEL | 1 | 0363-1898 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 15 sections |
Esomeprazole Magnesium | HUMAN OTC DRUG LABEL | 1 | 0363-3298 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 14 sections |
Esomeprazole Magnesium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2350 | CAPSULE, DELAYED RELEASE PELLETS | 20 mg | ORAL | ANDA | 30 sections |
Esomeprazole Magnesium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2351 | CAPSULE, DELAYED RELEASE PELLETS | 40 mg | ORAL | ANDA | 30 sections |
Naproxen and Esomeprazole Magnesium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-4385 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 33 sections |