flunoxaprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 1203 66934-18-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • flunoxaprofen
  • (S)-(+)-Flunoxaprofen
  • (S)-Flunoxaprofen
  • Molecular weight: 285.27
  • Formula: C16H12FNO3
  • CLOGP: 3.25
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.33
  • ALOGS: -3.76
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.663 Moderate 0.78
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.510 Moderate 0.78
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 132.130 10^-6 cm/s Moderate 0.78
dh-clint Dog hepatocyte intrinsic clearance 2.466 uL/min/10^6 cells Moderate 0.78
dppb Dog plasma protein binding (% unbound) 1.360 % Moderate 0.78
fcs-ppb Fetal calf serum protein binding (% unbound) 3.480 % Moderate 0.78
herg hERG pIC50 4.283 pIC50 Moderate 0.78
hh-clint Human hepatocyte intrinsic clearance 1.403 uL/min/10^6 cells Moderate 0.78
hlm-clint Human liver microsomal intrinsic clearance 3.090 uL/min/mg protein Moderate 0.78
hppb Human plasma protein binding (% unbound) 0.920 % Moderate 0.78
kinase-safety-class ACVR2B,AXL,EIF2AK3,GRK2,MAPK7,PDK1,PDK2,PDK4,PIK3CG,PRKDC,TGFBR1 11
kinase-selectivity-class ACVR2B,GRK2 2
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 7.798 Moderate 0.78
mh-clint Mouse hepatocyte intrinsic clearance 8.453 Moderate 0.78
mppb Mouse plasma protein binding (% unbound) 5.660 Moderate 0.78
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.798 Moderate 0.78
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 2.600 % Moderate 0.78
rh-clint Rat hepatocyte intrinsic clearance 1.641 uL/min/10^6 cells Moderate 0.78
rh-fuinc Rat hepatocyte fraction unbound in incubation 75.420 % Moderate 0.78
rppb Rat plasma protein binding (% unbound) 0.940 % Moderate 0.78
solubility-dd Solubility at pH 7.4 in DMSO 922.571 uM Moderate 0.78

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G02CC04 GENITO URINARY SYSTEM AND SEX HORMONES
OTHER GYNECOLOGICALS
OTHER GYNECOLOGICALS
Antiinflammatory products for vaginal administration
ATC M01AE15 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:50908 hepatotoxic agent
CHEBI has role CHEBI:64018 protein kinase C agonist

Related Drugs by ATC class:

G02CC Antiinflammatory products for vaginal administration 3 drugs
benzydamineibuprofennaproxen
M01AE Propionic acid derivatives 21 drugs
alminoprofenbenoxaprofendexibuprofendexketoprofendiphenhydramineesomeprazolefenbufenfenoprofenflurbiprofenibuprofenibuproxamindoprofen show all 21 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.05 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07219 KEGG_DRUG
C0060504 UMLSCUI
CHEBI:76154 CHEBI
CHEMBL1614641 ChEMBL_ID
DB13317 DRUGBANK_ID
C045356 MESH_SUPPLEMENTAL_RECORD_UI
68869 PUBCHEM_CID
4870 INN_ID
UKU5U19W9M UNII

Pharmaceutical products:

None