Stem definition | Drug id | CAS RN |
---|---|---|
anti-inflammatory, indometacin derivatives | 1440 | 53-86-1 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
0.10 | g | P |
0.10 | g | R |
0.10 | g | O |
0.10 | g | R |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.00 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 15 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 7.99 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 10, 1965 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Oligohydramnios | 420.57 | 12.06 | 134 | 21589 | 6232 | 63461067 |
Premature delivery | 179.68 | 12.06 | 118 | 21605 | 30163 | 63437136 |
Neck deformity | 158.19 | 12.06 | 49 | 21674 | 2072 | 63465227 |
Ankylosing spondylitis | 150.72 | 12.06 | 73 | 21650 | 10401 | 63456898 |
Neck mass | 140.14 | 12.06 | 51 | 21672 | 3552 | 63463747 |
Bone density abnormal | 113.46 | 12.06 | 43 | 21680 | 3355 | 63463944 |
Oesophageal spasm | 106.01 | 12.06 | 40 | 21683 | 3083 | 63464216 |
Oesophageal pain | 95.97 | 12.06 | 39 | 21684 | 3662 | 63463637 |
Exposure during pregnancy | 83.31 | 12.06 | 172 | 21551 | 155375 | 63311924 |
Premature baby | 81.75 | 12.06 | 63 | 21660 | 20672 | 63446627 |
Disability | 72.88 | 12.06 | 56 | 21667 | 18291 | 63449008 |
Premature labour | 65.21 | 12.06 | 45 | 21678 | 12459 | 63454840 |
Neonatal disorder | 63.25 | 12.06 | 18 | 21705 | 565 | 63466734 |
Lymphoedema | 60.79 | 12.06 | 42 | 21681 | 11650 | 63455649 |
Mood swings | 60.31 | 12.06 | 50 | 21673 | 18198 | 63449101 |
Maternal exposure during pregnancy | 57.78 | 12.06 | 186 | 21537 | 219876 | 63247423 |
Drug hypersensitivity | 55.73 | 12.06 | 232 | 21491 | 310455 | 63156844 |
Death | 54.77 | 12.06 | 30 | 21693 | 374351 | 63092948 |
Drug ineffective for unapproved indication | 53.34 | 12.06 | 62 | 21661 | 34001 | 63433298 |
Drug ineffective | 51.19 | 12.06 | 563 | 21160 | 1044202 | 62423097 |
Corneal perforation | 46.57 | 12.06 | 14 | 21709 | 534 | 63466765 |
Limb deformity | 43.27 | 12.06 | 23 | 21700 | 3979 | 63463320 |
Product use in unapproved indication | 42.21 | 12.06 | 146 | 21577 | 178934 | 63288365 |
Glossodynia | 39.09 | 12.06 | 7 | 21716 | 178869 | 63288430 |
Hypermobility syndrome | 37.10 | 12.06 | 13 | 21710 | 810 | 63466489 |
Low birth weight baby | 35.63 | 12.06 | 25 | 21698 | 7104 | 63460195 |
Migraine | 35.33 | 12.06 | 96 | 21627 | 103250 | 63364049 |
Maternal drugs affecting foetus | 34.95 | 12.06 | 22 | 21701 | 5220 | 63462079 |
Sleep apnoea syndrome | 34.34 | 12.06 | 46 | 21677 | 29087 | 63438212 |
Wound | 32.37 | 12.06 | 8 | 21715 | 163255 | 63304044 |
Grip strength decreased | 32.30 | 12.06 | 39 | 21684 | 22248 | 63445051 |
Bronchopulmonary dysplasia | 32.27 | 12.06 | 10 | 21713 | 423 | 63466876 |
Arthralgia | 31.93 | 12.06 | 316 | 21407 | 569394 | 62897905 |
Tinnitus | 31.39 | 12.06 | 49 | 21674 | 35579 | 63431720 |
Neonatal respiratory distress syndrome | 29.91 | 12.06 | 16 | 21707 | 2802 | 63464497 |
Back pain | 29.86 | 12.06 | 173 | 21550 | 263972 | 63203327 |
Polyarthritis | 29.84 | 12.06 | 26 | 21697 | 10120 | 63457179 |
Pemphigus | 29.43 | 12.06 | 13 | 21710 | 183713 | 63283586 |
Musculoskeletal stiffness | 29.31 | 12.06 | 133 | 21590 | 184485 | 63282814 |
Joint swelling | 29.23 | 12.06 | 202 | 21521 | 327464 | 63139835 |
Serotonin syndrome | 28.90 | 12.06 | 42 | 21681 | 28640 | 63438659 |
Joint abscess | 28.55 | 12.06 | 9 | 21714 | 403 | 63466896 |
Cellulitis staphylococcal | 26.91 | 12.06 | 10 | 21713 | 738 | 63466561 |
Neurodevelopmental disorder | 26.16 | 12.06 | 7 | 21716 | 174 | 63467125 |
Joint stiffness | 25.61 | 12.06 | 49 | 21674 | 41820 | 63425479 |
Uveitis | 25.12 | 12.06 | 26 | 21697 | 12527 | 63454772 |
Vascular rupture | 24.91 | 12.06 | 12 | 21711 | 1688 | 63465611 |
Adrenal suppression | 24.86 | 12.06 | 10 | 21713 | 914 | 63466385 |
Abdominal discomfort | 24.75 | 12.06 | 45 | 21678 | 320840 | 63146459 |
Neuralgia | 24.73 | 12.06 | 37 | 21686 | 25889 | 63441410 |
Foetal death | 24.27 | 12.06 | 24 | 21699 | 10956 | 63456343 |
Actinomycotic sepsis | 24.20 | 12.06 | 6 | 21717 | 109 | 63467190 |
Agitation | 24.01 | 12.06 | 59 | 21664 | 59698 | 63407601 |
Preterm premature rupture of membranes | 23.89 | 12.06 | 11 | 21712 | 1398 | 63465901 |
Angioedema | 23.27 | 12.06 | 51 | 21672 | 47914 | 63419385 |
Medication overuse headache | 22.37 | 12.06 | 9 | 21714 | 823 | 63466476 |
Dyspnoea | 21.74 | 12.06 | 135 | 21588 | 661178 | 62806121 |
Pulmonary hypertensive crisis | 21.72 | 12.06 | 7 | 21716 | 337 | 63466962 |
Foetal exposure during pregnancy | 20.28 | 12.06 | 38 | 21685 | 31924 | 63435375 |
Sacroiliitis | 20.05 | 12.06 | 13 | 21710 | 3244 | 63464055 |
Serum ferritin decreased | 19.88 | 12.06 | 11 | 21712 | 2059 | 63465240 |
Alopecia | 19.77 | 12.06 | 55 | 21668 | 337481 | 63129818 |
Therapeutic response unexpected | 19.67 | 12.06 | 28 | 21695 | 18731 | 63448568 |
Fibromyalgia | 19.29 | 12.06 | 66 | 21657 | 80354 | 63386945 |
Catheter site bruise | 19.28 | 12.06 | 7 | 21716 | 484 | 63466815 |
Systemic lupus erythematosus | 19.24 | 12.06 | 26 | 21697 | 208892 | 63258407 |
Large intestinal ulcer haemorrhage | 19.22 | 12.06 | 5 | 21718 | 111 | 63467188 |
Mycobacterium tuberculosis complex test positive | 19.02 | 12.06 | 11 | 21712 | 2240 | 63465059 |
Alpha tumour necrosis factor increased | 18.93 | 12.06 | 4 | 21719 | 34 | 63467265 |
Endothelin increased | 18.93 | 12.06 | 4 | 21719 | 34 | 63467265 |
Blood pressure diastolic increased | 18.72 | 12.06 | 20 | 21703 | 9990 | 63457309 |
Cystitis | 18.69 | 12.06 | 51 | 21672 | 54940 | 63412359 |
Oligoarthritis | 18.25 | 12.06 | 7 | 21716 | 564 | 63466735 |
Growth retardation | 18.25 | 12.06 | 9 | 21714 | 1332 | 63465967 |
Hyperhidrosis | 18.08 | 12.06 | 79 | 21644 | 107757 | 63359542 |
Swollen tongue | 18.02 | 12.06 | 38 | 21685 | 34762 | 63432537 |
Hydrops foetalis | 17.82 | 12.06 | 7 | 21716 | 601 | 63466698 |
Investigation abnormal | 17.70 | 12.06 | 10 | 21713 | 1948 | 63465351 |
Atrial fibrillation | 17.53 | 12.06 | 9 | 21714 | 116627 | 63350672 |
Tendonitis | 17.31 | 12.06 | 27 | 21696 | 19588 | 63447711 |
Hospitalisation | 17.19 | 12.06 | 4 | 21719 | 85077 | 63382222 |
Bronchitis | 16.91 | 12.06 | 86 | 21637 | 124849 | 63342450 |
Pharyngeal haematoma | 16.79 | 12.06 | 4 | 21719 | 61 | 63467238 |
Pharyngitis | 16.77 | 12.06 | 27 | 21696 | 20116 | 63447183 |
Impaired work ability | 16.75 | 12.06 | 25 | 21698 | 17450 | 63449849 |
Neck pain | 16.72 | 12.06 | 57 | 21666 | 69261 | 63398038 |
Oliguria | 16.70 | 12.06 | 18 | 21705 | 9083 | 63458216 |
Coccydynia | 16.52 | 12.06 | 9 | 21714 | 1634 | 63465665 |
Muscle spasticity | 16.51 | 12.06 | 28 | 21695 | 21766 | 63445533 |
Infective myositis | 16.50 | 12.06 | 4 | 21719 | 66 | 63467233 |
Ankle fracture | 16.35 | 12.06 | 25 | 21698 | 17830 | 63449469 |
Cerebral vasoconstriction | 16.12 | 12.06 | 8 | 21715 | 1200 | 63466099 |
Nerve degeneration | 16.12 | 12.06 | 4 | 21719 | 73 | 63467226 |
Intervertebral disc protrusion | 16.07 | 12.06 | 29 | 21694 | 23680 | 63443619 |
Ear pain | 15.95 | 12.06 | 37 | 21686 | 36081 | 63431218 |
Blood pressure fluctuation | 15.79 | 12.06 | 43 | 21680 | 46274 | 63421025 |
Fine motor skill dysfunction | 15.48 | 12.06 | 13 | 21710 | 4812 | 63462487 |
Benign vaginal neoplasm | 15.16 | 12.06 | 4 | 21719 | 94 | 63467205 |
Narcolepsy | 15.12 | 12.06 | 8 | 21715 | 1370 | 63465929 |
Pain | 15.05 | 12.06 | 345 | 21378 | 740283 | 62727016 |
Hirsutism | 15.03 | 12.06 | 8 | 21715 | 1387 | 63465912 |
Skin striae | 15.00 | 12.06 | 8 | 21715 | 1393 | 63465906 |
Myoglobin blood increased | 14.98 | 12.06 | 8 | 21715 | 1397 | 63465902 |
Visceral leishmaniasis | 14.83 | 12.06 | 6 | 21717 | 557 | 63466742 |
Focal nodular hyperplasia | 14.74 | 12.06 | 6 | 21717 | 565 | 63466734 |
External ear cellulitis | 14.70 | 12.06 | 5 | 21718 | 285 | 63467014 |
Corneal neovascularisation | 14.46 | 12.06 | 4 | 21719 | 113 | 63467186 |
Necrotising colitis | 14.43 | 12.06 | 6 | 21717 | 597 | 63466702 |
Nephropathy toxic | 14.41 | 12.06 | 17 | 21706 | 9462 | 63457837 |
Hypercholesterolaemia | 14.34 | 12.06 | 26 | 21697 | 21308 | 63445991 |
Chronic gastritis | 14.28 | 12.06 | 10 | 21713 | 2831 | 63464468 |
Mydriasis | 14.27 | 12.06 | 19 | 21704 | 11937 | 63455362 |
Arthritis bacterial | 14.05 | 12.06 | 14 | 21709 | 6449 | 63460850 |
White blood cell analysis abnormal | 14.04 | 12.06 | 3 | 21720 | 27 | 63467272 |
Decreased vibratory sense | 13.94 | 12.06 | 5 | 21718 | 334 | 63466965 |
Right ventricular hypertrophy | 13.54 | 12.06 | 6 | 21717 | 697 | 63466602 |
Gastroenteritis salmonella | 13.51 | 12.06 | 6 | 21717 | 701 | 63466598 |
Alkalosis | 13.50 | 12.06 | 5 | 21718 | 366 | 63466933 |
Wheezing | 13.46 | 12.06 | 8 | 21715 | 95587 | 63371712 |
Swelling face | 13.43 | 12.06 | 50 | 21673 | 63425 | 63403874 |
Apallic syndrome | 13.40 | 12.06 | 6 | 21717 | 715 | 63466584 |
Hypopyon | 13.31 | 12.06 | 6 | 21717 | 726 | 63466573 |
Hallucination | 13.15 | 12.06 | 45 | 21678 | 54772 | 63412527 |
Dysphonia | 13.15 | 12.06 | 41 | 21682 | 47573 | 63419726 |
Vision blurred | 12.94 | 12.06 | 64 | 21659 | 91860 | 63375439 |
Apgar score low | 12.92 | 12.06 | 6 | 21717 | 778 | 63466521 |
Myoclonus | 12.84 | 12.06 | 21 | 21702 | 15847 | 63451452 |
Intentional underdose | 12.80 | 12.06 | 8 | 21715 | 1874 | 63465425 |
Bradycardia foetal | 12.71 | 12.06 | 5 | 21718 | 431 | 63466868 |
Fluid retention | 12.62 | 12.06 | 47 | 21676 | 59639 | 63407660 |
Pulmonary valve incompetence | 12.33 | 12.06 | 7 | 21716 | 1376 | 63465923 |
Body temperature increased | 12.15 | 12.06 | 34 | 21689 | 37158 | 63430141 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Ankylosing spondylitis | 155.06 | 12.89 | 64 | 13437 | 5540 | 34937890 |
Ductus arteriosus premature closure | 102.01 | 12.89 | 23 | 13478 | 238 | 34943192 |
Gout | 54.71 | 12.89 | 51 | 13450 | 19202 | 34924228 |
Sacroiliitis | 47.93 | 12.89 | 19 | 13482 | 1479 | 34941951 |
Hepatitis B virus test positive | 47.38 | 12.89 | 13 | 13488 | 314 | 34943116 |
Drug ineffective | 43.59 | 12.89 | 313 | 13188 | 456438 | 34486992 |
Arthralgia | 43.21 | 12.89 | 154 | 13347 | 169887 | 34773543 |
Exostosis | 42.29 | 12.89 | 25 | 13476 | 4698 | 34938732 |
Tendon disorder | 41.86 | 12.89 | 21 | 13480 | 2854 | 34940576 |
Ankle fracture | 40.02 | 12.89 | 23 | 13478 | 4102 | 34939328 |
Premature baby | 39.25 | 12.89 | 43 | 13458 | 19590 | 34923840 |
Hypoaldosteronism | 38.81 | 12.89 | 10 | 13491 | 188 | 34943242 |
Duodenal perforation | 36.71 | 12.89 | 15 | 13486 | 1263 | 34942167 |
Mast cell activation syndrome | 36.50 | 12.89 | 10 | 13491 | 240 | 34943190 |
Psoriasis | 34.19 | 12.89 | 57 | 13444 | 38755 | 34904675 |
Arthritis | 33.07 | 12.89 | 50 | 13451 | 31296 | 34912134 |
Gastrointestinal haemorrhage | 32.42 | 12.89 | 91 | 13410 | 88386 | 34855044 |
Joint swelling | 31.84 | 12.89 | 71 | 13430 | 59819 | 34883611 |
Chest expansion decreased | 31.22 | 12.89 | 8 | 13493 | 147 | 34943283 |
Benign abdominal neoplasm | 29.72 | 12.89 | 7 | 13494 | 89 | 34943341 |
Drug hypersensitivity | 29.67 | 12.89 | 83 | 13418 | 80446 | 34862984 |
Psoriatic arthropathy | 29.02 | 12.89 | 37 | 13464 | 19761 | 34923669 |
Death | 28.93 | 12.89 | 70 | 13431 | 397979 | 34545451 |
Synovitis | 26.72 | 12.89 | 30 | 13471 | 14036 | 34929394 |
Foot fracture | 26.35 | 12.89 | 19 | 13482 | 4992 | 34938438 |
Gouty arthritis | 25.36 | 12.89 | 11 | 13490 | 1075 | 34942355 |
Juvenile idiopathic arthritis | 25.13 | 12.89 | 13 | 13488 | 1884 | 34941546 |
Gastric haemorrhage | 25.03 | 12.89 | 25 | 13476 | 10236 | 34933194 |
Axial spondyloarthritis | 24.74 | 12.89 | 8 | 13493 | 344 | 34943086 |
Neonatal disorder | 24.73 | 12.89 | 10 | 13491 | 820 | 34942610 |
Xanthelasma | 24.26 | 12.89 | 6 | 13495 | 95 | 34943335 |
Foot deformity | 23.39 | 12.89 | 17 | 13484 | 4520 | 34938910 |
Osteoarthritis | 23.31 | 12.89 | 34 | 13467 | 20608 | 34922822 |
Placental transfusion syndrome | 23.05 | 12.89 | 4 | 13497 | 8 | 34943422 |
Coarctation of the aorta | 22.39 | 12.89 | 8 | 13493 | 467 | 34942963 |
Back pain | 21.81 | 12.89 | 99 | 13402 | 121690 | 34821740 |
Sensitivity to weather change | 21.13 | 12.89 | 11 | 13490 | 1615 | 34941815 |
Caesarean section | 20.81 | 12.89 | 12 | 13489 | 2152 | 34941278 |
Neonatal respiratory distress syndrome | 20.53 | 12.89 | 15 | 13486 | 4019 | 34939411 |
Gastric ulcer | 19.47 | 12.89 | 27 | 13474 | 15623 | 34927807 |
Neck pain | 19.40 | 12.89 | 35 | 13466 | 25314 | 34918116 |
Water intoxication | 19.39 | 12.89 | 7 | 13494 | 421 | 34943009 |
Melaena | 18.86 | 12.89 | 42 | 13459 | 35338 | 34908092 |
Enthesopathy | 18.75 | 12.89 | 15 | 13486 | 4598 | 34938832 |
Osteopenia | 18.09 | 12.89 | 15 | 13486 | 4834 | 34938596 |
Duodenal ulcer | 17.87 | 12.89 | 21 | 13480 | 10311 | 34933119 |
Gastric bypass | 17.86 | 12.89 | 6 | 13495 | 291 | 34943139 |
Thoracic vertebral fracture | 17.73 | 12.89 | 10 | 13491 | 1720 | 34941710 |
Pulmonary sarcoidosis | 17.14 | 12.89 | 7 | 13494 | 589 | 34942841 |
Foetal exposure during pregnancy | 16.79 | 12.89 | 42 | 13459 | 38059 | 34905371 |
Myofascial pain syndrome | 16.46 | 12.89 | 6 | 13495 | 371 | 34943059 |
Erythroblast count increased | 16.42 | 12.89 | 3 | 13498 | 9 | 34943421 |
Joint range of motion decreased | 16.35 | 12.89 | 17 | 13484 | 7295 | 34936135 |
Stillbirth | 16.34 | 12.89 | 5 | 13496 | 179 | 34943251 |
Patent ductus arteriosus | 16.01 | 12.89 | 12 | 13489 | 3342 | 34940088 |
Tricuspid valve incompetence | 15.51 | 12.89 | 19 | 13482 | 9741 | 34933689 |
Tobacco abuse | 15.48 | 12.89 | 6 | 13495 | 440 | 34942990 |
Iridocyclitis | 15.46 | 12.89 | 9 | 13492 | 1643 | 34941787 |
Drug tolerance | 15.32 | 12.89 | 11 | 13490 | 2871 | 34940559 |
Procedural vomiting | 15.26 | 12.89 | 5 | 13496 | 224 | 34943206 |
Gastrointestinal ulcer | 15.17 | 12.89 | 9 | 13492 | 1702 | 34941728 |
Musculoskeletal stiffness | 15.15 | 12.89 | 46 | 13455 | 46634 | 34896796 |
Spinal deformity | 14.87 | 12.89 | 6 | 13495 | 489 | 34942941 |
Oromandibular dystonia | 14.80 | 12.89 | 6 | 13495 | 495 | 34942935 |
Sinusitis aspergillus | 14.76 | 12.89 | 4 | 13497 | 92 | 34943338 |
Hydrops foetalis | 14.62 | 12.89 | 7 | 13494 | 860 | 34942570 |
Pain | 14.32 | 12.89 | 131 | 13370 | 204544 | 34738886 |
Intraventricular haemorrhage neonatal | 13.73 | 12.89 | 5 | 13496 | 308 | 34943122 |
Neutropenia | 13.48 | 12.89 | 25 | 13476 | 156753 | 34786677 |
Faeces discoloured | 13.29 | 12.89 | 22 | 13479 | 14856 | 34928574 |
Pain in extremity | 13.29 | 12.89 | 89 | 13412 | 126424 | 34817006 |
Adulterated product | 13.22 | 12.89 | 3 | 13498 | 32 | 34943398 |
Foetal distress syndrome | 13.04 | 12.89 | 7 | 13494 | 1093 | 34942337 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Ankylosing spondylitis | 288.77 | 11.78 | 123 | 29245 | 12082 | 79702938 |
Neck deformity | 148.81 | 11.78 | 46 | 29322 | 1791 | 79713229 |
Neck mass | 119.66 | 11.78 | 49 | 29319 | 4355 | 79710665 |
Oesophageal spasm | 109.66 | 11.78 | 43 | 29325 | 3413 | 79711607 |
Bone density abnormal | 103.93 | 11.78 | 40 | 29328 | 3020 | 79712000 |
Oesophageal pain | 97.48 | 11.78 | 42 | 29326 | 4237 | 79710783 |
Drug ineffective | 83.01 | 11.78 | 679 | 28689 | 1080234 | 78634786 |
Sacroiliitis | 63.72 | 11.78 | 30 | 29338 | 3724 | 79711296 |
Corneal perforation | 61.35 | 11.78 | 19 | 29349 | 744 | 79714276 |
Lymphoedema | 60.23 | 11.78 | 44 | 29324 | 12369 | 79702651 |
Arthralgia | 58.40 | 11.78 | 385 | 28983 | 571418 | 79143602 |
Back pain | 56.71 | 11.78 | 242 | 29126 | 303938 | 79411082 |
Musculoskeletal stiffness | 52.86 | 11.78 | 163 | 29205 | 174845 | 79540175 |
Ankle fracture | 52.10 | 11.78 | 46 | 29322 | 16923 | 79698097 |
Disability | 51.75 | 11.78 | 46 | 29322 | 17074 | 79697946 |
Death | 50.33 | 11.78 | 82 | 29286 | 566432 | 79148588 |
Mood swings | 49.61 | 11.78 | 48 | 29320 | 19832 | 79695188 |
Joint swelling | 48.75 | 11.78 | 223 | 29145 | 288423 | 79426597 |
Drug hypersensitivity | 46.15 | 11.78 | 225 | 29143 | 298691 | 79416329 |
Drug ineffective for unapproved indication | 46.04 | 11.78 | 74 | 29294 | 51164 | 79663856 |
Sleep apnoea syndrome | 44.77 | 11.78 | 61 | 29307 | 36417 | 79678603 |
Hepatitis B virus test positive | 42.55 | 11.78 | 13 | 29355 | 486 | 79714534 |
Hypermobility syndrome | 41.50 | 11.78 | 13 | 29355 | 529 | 79714491 |
Pain | 38.07 | 11.78 | 411 | 28957 | 703391 | 79011629 |
Migraine | 36.80 | 11.78 | 92 | 29276 | 87401 | 79627619 |
Limb deformity | 35.66 | 11.78 | 20 | 29348 | 3570 | 79711450 |
Gout | 32.84 | 11.78 | 43 | 29325 | 24706 | 79690314 |
Hypoaldosteronism | 32.68 | 11.78 | 10 | 29358 | 376 | 79714644 |
Tinnitus | 30.62 | 11.78 | 57 | 29311 | 44276 | 79670744 |
Neck pain | 30.36 | 11.78 | 78 | 29290 | 75339 | 79639681 |
Chest expansion decreased | 29.78 | 11.78 | 8 | 29360 | 187 | 79714833 |
Tendon disorder | 29.39 | 11.78 | 23 | 29345 | 7163 | 79707857 |
Gastrointestinal haemorrhage | 28.62 | 11.78 | 119 | 29249 | 147600 | 79567420 |
Premature delivery | 28.43 | 11.78 | 39 | 29329 | 23428 | 79691592 |
Arthritis | 28.39 | 11.78 | 100 | 29268 | 114780 | 79600240 |
Gastric haemorrhage | 27.92 | 11.78 | 31 | 29337 | 15019 | 79700001 |
Gastric ulcer | 27.81 | 11.78 | 47 | 29321 | 33858 | 79681162 |
Right ventricular hypertension | 27.63 | 11.78 | 4 | 29364 | 0 | 79715020 |
Psoriatic arthropathy | 26.71 | 11.78 | 76 | 29292 | 77923 | 79637097 |
Fibromyalgia | 26.37 | 11.78 | 67 | 29301 | 64273 | 79650747 |
Neuralgia | 25.70 | 11.78 | 45 | 29323 | 33339 | 79681681 |
Joint abscess | 25.48 | 11.78 | 9 | 29359 | 533 | 79714487 |
Investigation abnormal | 24.66 | 11.78 | 13 | 29355 | 2053 | 79712967 |
Actinomycotic sepsis | 24.19 | 11.78 | 6 | 29362 | 101 | 79714919 |
Duodenal perforation | 24.05 | 11.78 | 13 | 29355 | 2159 | 79712861 |
Joint stiffness | 23.94 | 11.78 | 49 | 29319 | 40781 | 79674239 |
Large intestinal ulcer | 23.26 | 11.78 | 17 | 29351 | 4780 | 79710240 |
Ductus arteriosus premature closure | 23.24 | 11.78 | 5 | 29363 | 43 | 79714977 |
Psoriasis | 23.01 | 11.78 | 79 | 29289 | 89508 | 79625512 |
Neutropenia | 22.48 | 11.78 | 45 | 29323 | 287665 | 79427355 |
Benign abdominal neoplasm | 22.48 | 11.78 | 7 | 29361 | 279 | 79714741 |
Dysstasia | 22.14 | 11.78 | 38 | 29330 | 27708 | 79687312 |
Uveitis | 21.96 | 11.78 | 29 | 29339 | 16801 | 79698219 |
Blood pressure fluctuation | 21.62 | 11.78 | 64 | 29304 | 67081 | 79647939 |
Xanthelasma | 21.40 | 11.78 | 6 | 29362 | 165 | 79714855 |
Vascular rupture | 21.25 | 11.78 | 11 | 29357 | 1674 | 79713346 |
Axial spondyloarthritis | 21.12 | 11.78 | 8 | 29360 | 578 | 79714442 |
Intestinal diaphragm disease | 21.09 | 11.78 | 7 | 29361 | 343 | 79714677 |
Duodenal ulcer | 21.04 | 11.78 | 28 | 29340 | 16341 | 79698679 |
Glossodynia | 20.99 | 11.78 | 6 | 29362 | 103331 | 79611689 |
Blood pressure diastolic increased | 20.44 | 11.78 | 26 | 29342 | 14516 | 79700504 |
Neonatal disorder | 20.15 | 11.78 | 4 | 29364 | 22 | 79714998 |
Gouty arthritis | 19.76 | 11.78 | 10 | 29358 | 1451 | 79713569 |
Malignant neoplasm progression | 19.57 | 11.78 | 13 | 29355 | 135977 | 79579043 |
Tendonitis | 19.49 | 11.78 | 33 | 29335 | 23797 | 79691223 |
Oligoarthritis | 19.48 | 11.78 | 8 | 29360 | 716 | 79714304 |
Myocardial infarction | 19.32 | 11.78 | 125 | 29243 | 184004 | 79531016 |
Catheter site bruise | 19.25 | 11.78 | 7 | 29361 | 451 | 79714569 |
Juvenile idiopathic arthritis | 18.95 | 11.78 | 15 | 29353 | 4748 | 79710272 |
Ear pain | 18.75 | 11.78 | 39 | 29329 | 32830 | 79682190 |
Right ventricular hypertrophy | 18.69 | 11.78 | 10 | 29358 | 1627 | 79713393 |
Osteopenia | 18.55 | 11.78 | 28 | 29340 | 18336 | 79696684 |
Wound | 18.27 | 11.78 | 10 | 29358 | 116169 | 79598851 |
Alpha tumour necrosis factor increased | 17.88 | 11.78 | 4 | 29364 | 42 | 79714978 |
Hyperhidrosis | 17.87 | 11.78 | 106 | 29262 | 151386 | 79563634 |
Cystitis | 17.68 | 11.78 | 51 | 29317 | 52681 | 79662339 |
Exostosis | 17.45 | 11.78 | 26 | 29342 | 16832 | 79698188 |
Large intestinal ulcer haemorrhage | 17.45 | 11.78 | 6 | 29362 | 328 | 79714692 |
Adrenal suppression | 17.26 | 11.78 | 9 | 29359 | 1390 | 79713630 |
Hypotension | 16.98 | 11.78 | 94 | 29274 | 440223 | 79274797 |
Angioedema | 16.93 | 11.78 | 64 | 29304 | 75971 | 79639049 |
Fluid retention | 16.58 | 11.78 | 60 | 29308 | 69749 | 79645271 |
Febrile neutropenia | 16.49 | 11.78 | 38 | 29330 | 230961 | 79484059 |
Bronchitis | 16.44 | 11.78 | 93 | 29275 | 130551 | 79584469 |
Hand deformity | 16.26 | 11.78 | 9 | 29359 | 103910 | 79611110 |
Gastrointestinal ulcer | 16.23 | 11.78 | 12 | 29356 | 3434 | 79711586 |
Mast cell activation syndrome | 16.18 | 11.78 | 7 | 29361 | 713 | 79714307 |
Trigger finger | 16.10 | 11.78 | 13 | 29355 | 4232 | 79710788 |
Mycobacterium tuberculosis complex test positive | 16.10 | 11.78 | 11 | 29357 | 2781 | 79712239 |
Cellulitis staphylococcal | 15.78 | 11.78 | 8 | 29360 | 1165 | 79713855 |
Water intoxication | 15.69 | 11.78 | 7 | 29361 | 767 | 79714253 |
Muscle spasticity | 15.31 | 11.78 | 28 | 29340 | 21447 | 79693573 |
Stress | 15.30 | 11.78 | 64 | 29304 | 79548 | 79635472 |
Benign vaginal neoplasm | 15.30 | 11.78 | 4 | 29364 | 84 | 79714936 |
Grip strength decreased | 14.95 | 11.78 | 28 | 29340 | 21841 | 79693179 |
Exposure during pregnancy | 14.77 | 11.78 | 75 | 29293 | 101057 | 79613963 |
Serotonin syndrome | 14.57 | 11.78 | 43 | 29325 | 44984 | 79670036 |
Hirsutism | 14.55 | 11.78 | 8 | 29360 | 1374 | 79713646 |
Pharyngitis | 14.50 | 11.78 | 28 | 29340 | 22347 | 79692673 |
Product dose omission issue | 14.43 | 11.78 | 45 | 29323 | 247492 | 79467528 |
Coccydynia | 14.18 | 11.78 | 9 | 29359 | 2012 | 79713008 |
Melaena | 14.18 | 11.78 | 52 | 29316 | 60838 | 79654182 |
Cerebral vasoconstriction | 14.09 | 11.78 | 8 | 29360 | 1462 | 79713558 |
Arthritis bacterial | 13.86 | 11.78 | 17 | 29351 | 9149 | 79705871 |
Endothelin increased | 13.82 | 11.78 | 3 | 29365 | 27 | 79714993 |
White blood cell analysis abnormal | 13.82 | 11.78 | 3 | 29365 | 27 | 79714993 |
Vision blurred | 13.73 | 11.78 | 76 | 29292 | 105822 | 79609198 |
Episcleritis | 13.63 | 11.78 | 7 | 29361 | 1048 | 79713972 |
Fine motor skill dysfunction | 13.49 | 11.78 | 13 | 29355 | 5344 | 79709676 |
Intervertebral disc protrusion | 13.44 | 11.78 | 28 | 29340 | 23593 | 79691427 |
Urticaria | 13.32 | 11.78 | 115 | 29253 | 185086 | 79529934 |
Pharyngeal haematoma | 13.29 | 11.78 | 4 | 29364 | 142 | 79714878 |
Leukopenia | 13.24 | 11.78 | 14 | 29354 | 116499 | 79598521 |
Drug intolerance | 13.17 | 11.78 | 152 | 29216 | 263967 | 79451053 |
Swollen tongue | 13.15 | 11.78 | 40 | 29328 | 42530 | 79672490 |
Facial paresis | 13.14 | 11.78 | 13 | 29355 | 5513 | 79709507 |
Premature baby | 13.13 | 11.78 | 11 | 29357 | 3769 | 79711251 |
Secondary adrenocortical insufficiency | 13.09 | 11.78 | 10 | 29358 | 3004 | 79712016 |
Dizziness | 13.07 | 11.78 | 269 | 29099 | 526172 | 79188848 |
Hyponatraemia | 12.89 | 11.78 | 29 | 29339 | 177819 | 79537201 |
Treatment failure | 12.86 | 11.78 | 107 | 29261 | 170379 | 79544641 |
Corneal neovascularisation | 12.83 | 11.78 | 4 | 29364 | 160 | 79714860 |
Focal nodular hyperplasia | 12.81 | 11.78 | 6 | 29362 | 736 | 79714284 |
Hypercholesterolaemia | 12.70 | 11.78 | 27 | 29341 | 23068 | 79691952 |
Synovitis | 12.68 | 11.78 | 97 | 29271 | 150637 | 79564383 |
Infective myositis | 12.60 | 11.78 | 4 | 29364 | 170 | 79714850 |
Myoclonus | 12.60 | 11.78 | 30 | 29338 | 27630 | 79687390 |
Procedural vomiting | 12.44 | 11.78 | 6 | 29362 | 785 | 79714235 |
Prostate cancer recurrent | 12.25 | 11.78 | 6 | 29362 | 812 | 79714208 |
Skin striae | 12.24 | 11.78 | 8 | 29360 | 1880 | 79713140 |
Wheezing | 12.19 | 11.78 | 15 | 29353 | 116649 | 79598371 |
Enthesopathy | 12.16 | 11.78 | 18 | 29350 | 11590 | 79703430 |
Alopecia | 12.16 | 11.78 | 44 | 29324 | 231311 | 79483709 |
Genital hypoaesthesia | 12.03 | 11.78 | 4 | 29364 | 197 | 79714823 |
Oligohydramnios | 12 | 11.78 | 10 | 29358 | 3402 | 79711618 |
Neuropathy peripheral | 12.00 | 11.78 | 21 | 29347 | 141284 | 79573736 |
Anxiety | 11.94 | 11.78 | 142 | 29226 | 248370 | 79466650 |
Pulmonary sarcoidosis | 11.88 | 11.78 | 7 | 29361 | 1370 | 79713650 |
Depression | 11.83 | 11.78 | 127 | 29241 | 216663 | 79498357 |
None
Source | Code | Description |
---|---|---|
ATC | C01EB03 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY OTHER CARDIAC PREPARATIONS Other cardiac preparations |
ATC | M01AB01 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Acetic acid derivatives and related substances |
ATC | M01AB51 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Acetic acid derivatives and related substances |
ATC | M02AA23 | MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use |
ATC | S01BC01 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Antiinflammatory agents, non-steroids |
ATC | S01CC02 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Antiinflammatory agents, non-steroids and antiinfectives in combination |
FDA CS | M0001335 | Anti-Inflammatory Agents, Non-Steroidal |
FDA MoA | N0000000160 | Cyclooxygenase Inhibitors |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D016861 | Cyclooxygenase Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D006074 | Gout Suppressants |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D012102 | Reproductive Control Agents |
MeSH PA | D018689 | Sensory System Agents |
MeSH PA | D015149 | Tocolytic Agents |
FDA EPC | N0000175722 | Nonsteroidal Anti-inflammatory Drug |
CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
CHEBI has role | CHEBI:35544 | cyclooxygenase inhibitors |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:35845 | gout suppressants |
CHEBI has role | CHEBI:49103 | drug metabolites |
CHEBI has role | CHEBI:76206 | xenobiotic metabolites |
CHEBI has role | CHEBI:78298 | environmental contaminants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Ankylosing spondylitis | indication | 9631008 | DOID:7147 |
Tendinitis | indication | 34840004 | DOID:971 |
Tenosynovitis | indication | 67801009 | DOID:970 |
Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
Patent ductus arteriosus | indication | 83330001 | DOID:13832 |
Bursitis | indication | 84017003 | DOID:2965 |
Gout | indication | 90560007 | DOID:13189 |
Bursitis of shoulder | indication | 239961006 | |
Osteoarthritis | indication | 396275006 | |
Synovitis | indication | 416209007 | DOID:2703 |
Shoulder Tendonitis | indication | ||
Pericarditis | off-label use | 3238004 | DOID:1787 |
Premature labor | off-label use | 6383007 | |
Renal colic | off-label use | 7093002 | |
Pseudoprimary hyperaldosteronism | off-label use | 71275003 | |
Nephrogenic diabetes insipidus | off-label use | 111395007 | DOID:12387 |
Dysmenorrhea | off-label use | 266599000 | |
Fever | off-label use | 386661006 | |
Twin reversal arterial perfusion syndrome | off-label use | 417006004 | |
Necrotizing enterocolitis in fetus OR newborn | contraindication | 2707005 | |
Proctitis | contraindication | 3951002 | DOID:3127 |
Acute hemorrhage | contraindication | 8573003 | |
Rectal hemorrhage | contraindication | 12063002 | |
Hyperkalemia | contraindication | 14140009 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Parkinsonism | contraindication | 32798002 | |
Dehydration | contraindication | 34095006 | |
Depressive disorder | contraindication | 35489007 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Chronic heart failure | contraindication | 48447003 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Duodenal ulcer disease | contraindication | 51868009 | DOID:1724 |
Gastrointestinal perforation | contraindication | 51875005 | |
Stomatitis | contraindication | 61170000 | DOID:9637 |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Hemorrhoids | contraindication | 70153002 | DOID:9746 |
Corneal deposit | contraindication | 74460005 | DOID:11547 |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Heart failure | contraindication | 84114007 | DOID:6000 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Bacterial infectious disease | contraindication | 87628006 | |
Hyponatremia | contraindication | 89627008 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Blurring of visual image | contraindication | 111516008 | |
Seizure disorder | contraindication | 128613002 | |
Liver function tests abnormal | contraindication | 166603001 | |
Asthma | contraindication | 195967001 | DOID:2841 |
Sepsis of the newborn | contraindication | 206376005 | |
Coronary artery bypass graft | contraindication | 232717009 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Esophageal dysmotility | contraindication | 266434009 | DOID:9192 |
Cerebral hemorrhage | contraindication | 274100004 | |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Malignant tumor of colon | contraindication | 363406005 | DOID:219 |
Cardiovascular event risk | contraindication | 395112001 | |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Diverticular disease | contraindication | 397881000 | |
Smokes tobacco daily | contraindication | 449868002 | |
Psychiatric Disturbance | contraindication | ||
Intraventricular Hemorrhage In Newborn | contraindication | ||
Congenital Heart Defect Requiring Open Patent Ductus Arteriosus | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.45 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
20MG | TIVORBEX | GENUS | N204768 | Feb. 24, 2014 | DISCN | CAPSULE | ORAL | 9089471 | April 23, 2030 | TREATMENT OF PAIN |
40MG | TIVORBEX | GENUS | N204768 | Feb. 24, 2014 | DISCN | CAPSULE | ORAL | 9089471 | April 23, 2030 | TREATMENT OF PAIN |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
50MG | INDOMETHACIN | ZYDUS | A216184 | Aug. 2, 2023 | RX | SUPPOSITORY | RECTAL | Jan. 30, 2024 | COMPETITIVE GENERIC THERAPY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 1 | Enzyme | INHIBITOR | IC50 | 7.21 | WOMBAT-PK | CHEMBL | |||
Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 6.33 | WOMBAT-PK | CHEMBL | |||
Multidrug resistance-associated protein 1 | Transporter | IC50 | 4.92 | CHEMBL | |||||
Androgen receptor | Nuclear hormone receptor | EC50 | 9.85 | CHEMBL | |||||
Prostaglandin D2 receptor 2 | GPCR | Ki | 6.53 | WOMBAT-PK | |||||
Dehydrogenase/reductase SDR family member 9 | Enzyme | IC50 | 4.85 | CHEMBL | |||||
Aldose reductase | Enzyme | IC50 | 5.22 | CHEMBL | |||||
Aldo-keto reductase family 1 member C2 | Enzyme | IC50 | 4.44 | CHEMBL | |||||
Aldo-keto reductase family 1 member C3 | Enzyme | IC50 | 7 | CHEMBL | |||||
Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | AGONIST | Kd | 7.38 | IUPHAR | ||||
Prostaglandin E2 receptor EP2 subtype | GPCR | Ki | 7.69 | PDSP | |||||
Lactoylglutathione lyase | Enzyme | Ki | 4.74 | CHEMBL | |||||
Cytochrome c oxidase subunit 2 | Enzyme | IC50 | 6.21 | CHEMBL | |||||
Interleukin-8 | Cytokine | IC50 | 7.30 | CHEMBL | |||||
Potassium voltage-gated channel subfamily A member 7 | Ion channel | Ki | 7.50 | WOMBAT-PK | |||||
Prostaglandin E synthase | Enzyme | IC50 | 4.39 | CHEMBL | |||||
Aldo-keto reductase family 1 member C4 | Enzyme | IC50 | 4.27 | CHEMBL | |||||
Nicotinate phosphoribosyltransferase | Enzyme | Ki | 9.82 | CHEMBL | |||||
Multidrug resistance protein 1 | Transporter | IC50 | 4.49 | CHEMBL | |||||
Aldose reductase | Enzyme | IC50 | 5.44 | DRUG MATRIX | |||||
Prostaglandin G/H synthase 2 | Enzyme | IC50 | 8.19 | CHEMBL | |||||
Prostaglandin G/H synthase 1 | Enzyme | IC50 | 8.70 | CHEMBL | |||||
Aldose reductase | Enzyme | IC50 | 5.30 | CHEMBL | |||||
Prostaglandin G/H synthase 1 | Enzyme | Ki | 5.10 | CHEMBL | |||||
Prostaglandin-H2 D-isomerase | Enzyme | IC50 | 6.30 | CHEMBL | |||||
Prostaglandin G/H synthase 1 | Enzyme | IC50 | 8.22 | CHEMBL | |||||
Prostaglandin G/H synthase 2 | Enzyme | IC50 | 6.47 | CHEMBL | |||||
Prostaglandin G/H synthase 1 | Enzyme | IC50 | 8.39 | CHEMBL | |||||
Cyclooxygenase | Enzyme | IC50 | 6.37 | CHEMBL | |||||
Cyclooxygenase | Enzyme | IC50 | 7 | CHEMBL | |||||
Prostaglandin G/H synthase (cyclooxygenase) | Enzyme | IC50 | 6.82 | CHEMBL | |||||
Nitric oxide synthase, inducible | Enzyme | IC50 | 4.70 | CHEMBL | |||||
Prostaglandin D2 receptor 2 | GPCR | AGONIST | Ki | 6 | IUPHAR | ||||
Prostaglandin G/H synthase 2 | Enzyme | IC50 | 8 | CHEMBL |
ID | Source |
---|---|
D00141 | KEGG_DRUG |
74252-25-8 | SECONDARY_CAS_RN |
4017890 | VANDF |
4017891 | VANDF |
C0021246 | UMLSCUI |
CHEBI:49662 | CHEBI |
IMN | PDB_CHEM_ID |
CHEMBL6 | ChEMBL_ID |
CHEMBL3989410 | ChEMBL_ID |
DB00328 | DRUGBANK_ID |
D007213 | MESH_DESCRIPTOR_UI |
3715 | PUBCHEM_CID |
1909 | IUPHAR_LIGAND_ID |
1524 | INN_ID |
XXE1CET956 | UNII |
1294612 | RXNORM |
2387 | MMSL |
2393 | MMSL |
4877 | MMSL |
d00039 | MMSL |
002373 | NDDF |
002374 | NDDF |
373513008 | SNOMEDCT_US |
60149003 | SNOMEDCT_US |
783274005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Indomethacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1113 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | ANDA | 13 sections |
Indomethacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1113 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | ANDA | 13 sections |
INDOMETHACIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0176 | SUPPOSITORY | 50 mg | RECTAL | ANDA | 14 sections |
Indomethacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-083 | CAPSULE | 50 mg | ORAL | ANDA | 27 sections |
Indomethacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-919 | CAPSULE, EXTENDED RELEASE | 75 mg | ORAL | ANDA | 12 sections |
Indomethacin | Human Prescription Drug Label | 1 | 10544-935 | CAPSULE, EXTENDED RELEASE | 75 mg | ORAL | ANDA | 24 sections |
INDOMETHACIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10702-016 | CAPSULE, EXTENDED RELEASE | 75 mg | ORAL | ANDA | 28 sections |
INDOMETHACIN ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-160 | CAPSULE | 75 mg | ORAL | ANDA | 14 sections |
INDOMETHACIN ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-838 | CAPSULE | 75 mg | ORAL | ANDA | 14 sections |
INDOMETHACIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-130 | CAPSULE | 50 mg | ORAL | ANDA | 24 sections |
Indomethacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-522 | CAPSULE | 25 mg | ORAL | ANDA | 27 sections |
Indomethacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-523 | CAPSULE | 50 mg | ORAL | ANDA | 23 sections |
Indomethacin | Human Prescription Drug Label | 1 | 31722-542 | CAPSULE | 25 mg | ORAL | ANDA | 27 sections |
Indomethacin | Human Prescription Drug Label | 1 | 31722-542 | CAPSULE | 25 mg | ORAL | ANDA | 27 sections |
Indomethacin | Human Prescription Drug Label | 1 | 31722-543 | CAPSULE | 50 mg | ORAL | ANDA | 27 sections |
Indomethacin | Human Prescription Drug Label | 1 | 31722-543 | CAPSULE | 50 mg | ORAL | ANDA | 27 sections |
Indomethacin | Human Prescription Drug Label | 1 | 31722-565 | CAPSULE, EXTENDED RELEASE | 75 mg | ORAL | ANDA | 24 sections |
Indomethacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 35356-697 | CAPSULE | 50 mg | ORAL | ANDA | 27 sections |
Indomethacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 35356-697 | CAPSULE | 50 mg | ORAL | ANDA | 27 sections |
INDOCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42211-101 | SUSPENSION | 25 mg | ORAL | NDA | 28 sections |
INDOCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42211-102 | SUPPOSITORY | 50 mg | RECTAL | ANDA | 29 sections |
Tivorbex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42211-201 | CAPSULE | 20 mg | ORAL | NDA | 28 sections |
Tivorbex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42211-202 | CAPSULE | 40 mg | ORAL | NDA | 28 sections |
Indomethacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-081 | CAPSULE | 50 mg | ORAL | ANDA | 27 sections |
INDOMETHACIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-237 | CAPSULE | 25 mg | ORAL | ANDA | 25 sections |
Indomethacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-368 | CAPSULE | 25 mg | ORAL | ANDA | 27 sections |
Indomethacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-368 | CAPSULE | 25 mg | ORAL | ANDA | 27 sections |
Indomethacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-773 | CAPSULE | 25 mg | ORAL | ANDA | 27 sections |
Indomethacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-773 | CAPSULE | 25 mg | ORAL | ANDA | 27 sections |
Indomethacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-773 | CAPSULE | 25 mg | ORAL | ANDA | 27 sections |