indomethacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory, indometacin derivatives 1440 53-86-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • indomethacin hydrochloride
  • indomethacin HCl
  • indocin
  • indomethacin
  • indometacine
  • indomethacine
  • indometacin
  • indomethacin sodium
A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES. Additional data needed to determine whether in vitro activity against SARS-CoV-2 corresponds with clinical efficacy in the treatment of COVID-19.
  • Molecular weight: 357.79
  • Formula: C19H16ClNO4
  • CLOGP: 4.18
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 68.53
  • ALOGS: -5.17
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O
0.10 g P
0.10 g R
0.10 g O
0.10 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 15 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 7.99 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.40 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,EIF2AK3,GRK2,ITK,MAPK7,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PRKDC 12
kinase-selectivity-class ACVR2B,EIF2AK3,PDK4 3
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.795 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
rat-kpuu-brain Rat brain Kpuu 0.187 % High 1

Approvals:

DateAgencyCompanyOrphan
June 10, 1965 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Oligohydramnios 419.41 11.94 140 32949 7061 90588297
Drug ineffective for unapproved indication 271.80 11.94 212 32877 66432 90528926
Swollen tongue 231.57 11.94 166 32923 45790 90549568
Angioedema 207.08 11.94 179 32910 64697 90530661
Premature delivery 197.54 11.94 141 32948 38621 90556737
Dysphonia 197.19 11.94 172 32917 62912 90532446
Swelling face 174.36 11.94 180 32909 81172 90514186
Neck deformity 153.52 11.94 49 33040 2140 90593218
Ankylosing spondylitis 150.04 11.94 80 33009 13053 90582305
Neck mass 133.19 11.94 51 33038 3831 90591527
Bone density abnormal 102.51 11.94 43 33046 4097 90591261
Oesophageal spasm 100.62 11.94 40 33049 3321 90592037
Oesophageal pain 87.24 11.94 39 33050 4335 90591023
Drug intolerance 86.75 11.94 358 32731 447233 90148125
Premature baby 77.56 11.94 68 33021 25009 90570349
Death 71.29 11.94 39 33050 456512 90138846
Exposure during pregnancy 69.44 11.94 218 32871 238192 90357166
Premature labour 66.61 11.94 48 33041 13328 90582030
Porphyria acute 66.41 11.94 54 33035 17921 90577437
Mood swings 63.74 11.94 56 33033 20646 90574712
Drug ineffective 62.83 11.94 775 32314 1383523 89211835
Neonatal disorder 61.82 11.94 18 33071 574 90594784
Serotonin syndrome 59.01 11.94 71 33018 37816 90557542
Medication overuse headache 56.12 11.94 21 33068 1480 90593878
Product use in unapproved indication 52.25 11.94 252 32837 335984 90259374
Nephropathy toxic 50.88 11.94 40 33049 12648 90582710
Lymphoedema 50.14 11.94 41 33048 13712 90581646
Actinomycotic sepsis 46.17 11.94 12 33077 248 90595110
Corneal perforation 44.13 11.94 14 33075 599 90594759
Off label use 43.48 11.94 602 32487 1101650 89493708
Maternal exposure during pregnancy 43.01 11.94 251 32838 359812 90235546
Disability 42.84 11.94 63 33026 40682 90554676
Cellulitis staphylococcal 41.96 11.94 15 33074 928 90594430
Limb deformity 41.07 11.94 23 33066 4129 90591229
Herpes zoster infection neurological 37.35 11.94 12 33077 535 90594823
Hypersensitivity 36.90 11.94 288 32801 454389 90140969
Low birth weight baby 36.15 11.94 29 33060 9438 90585920
Growth retardation 35.88 11.94 16 33073 1767 90593591
Hypermobility syndrome 35.23 11.94 13 33076 881 90594477
Musculoskeletal stiffness 34.28 11.94 205 32884 296327 90299031
Drug hypersensitivity 34.02 11.94 287 32802 463322 90132036
Maternal drugs affecting foetus 33.98 11.94 22 33067 5133 90590225
Focal nodular hyperplasia 33.30 11.94 12 33077 760 90594598
Bronchopulmonary dysplasia 31.88 11.94 11 33078 613 90594745
Chronic idiopathic pain syndrome 31.74 11.94 7 33082 69 90595289
Allergic sinusitis 30.29 11.94 15 33074 2098 90593260
Antinuclear antibody positive 28.45 11.94 25 33064 9216 90586142
Uveitis 28.43 11.94 32 33057 15871 90579487
Neurodevelopmental disorder 27.78 11.94 8 33081 245 90595113
Sleep apnoea syndrome 27.65 11.94 45 33044 31702 90563656
X-ray abnormal 27.54 11.94 55 33034 45369 90549989
Neonatal respiratory distress syndrome 27.51 11.94 16 33073 3085 90592273
Synovial disorder 27.43 11.94 16 33073 3102 90592256
Headache 27.25 11.94 454 32635 862292 89733066
Joint abscess 27.12 11.94 9 33080 445 90594913
Adrenal suppression 26.73 11.94 11 33078 998 90594360
Glossodynia 26.59 11.94 48 33041 321731 90273627
Vascular rupture 26.24 11.94 13 33076 1820 90593538
Dyspnoea 25.90 11.94 202 32887 880753 89714605
Apallic syndrome 25.68 11.94 10 33079 786 90594572
Tendonitis 25.34 11.94 35 33054 21337 90574021
Night sweats 24.84 11.94 103 32986 128663 90466695
Tinnitus 24.72 11.94 51 33038 43051 90552307
Atrial fibrillation 24.60 11.94 9 33080 133602 90461756
Joint effusion 24.46 11.94 33 33056 19677 90575681
Abdominal discomfort 24.25 11.94 91 32998 477237 90118121
Blood iron decreased 23.72 11.94 31 33058 17928 90577430
Neutropenia 22.97 11.94 29 33060 224875 90370483
Pulmonary hypertensive crisis 22.79 11.94 8 33081 469 90594889
Myoglobin blood increased 22.19 11.94 11 33078 1541 90593817
Vitiligo 21.72 11.94 12 33077 2098 90593260
Preterm premature rupture of membranes 21.61 11.94 11 33078 1630 90593728
Back pain 21.48 11.94 193 32896 316982 90278376
Blood pressure diastolic increased 21.44 11.94 25 33064 12881 90582477
Necrotising colitis 20.68 11.94 10 33079 1328 90594030
Foetal exposure during pregnancy 20.27 11.94 47 33042 42928 90552430
Agitation 20.09 11.94 62 33027 67036 90528322
Joint swelling 19.75 11.94 275 32814 503025 90092333
Vitamin B12 decreased 19.71 11.94 16 33073 5294 90590064
Endothelin increased 19.61 11.94 4 33085 26 90595332
Alopecia 19.36 11.94 104 32985 494967 90100391
Alpha tumour necrosis factor increased 19.36 11.94 4 33085 28 90595330
Coccydynia 19.11 11.94 11 33078 2080 90593278
Obliterative bronchiolitis 19.06 11.94 12 33077 2669 90592689
Pharyngitis 18.96 11.94 31 33058 21916 90573442
Feeling hot 18.82 11.94 67 33022 77941 90517417
Large intestinal ulcer haemorrhage 18.73 11.94 5 33084 115 90595243
Sacroiliitis 18.44 11.94 14 33075 4205 90591153
Arthralgia 18.42 11.94 392 32697 778130 89817228
Oliguria 18.35 11.94 21 33068 10603 90584755
Colitis ulcerative 18.33 11.94 56 33033 60210 90535148
Investigation abnormal 18.20 11.94 11 33078 2276 90593082
Secondary adrenocortical insufficiency 18.06 11.94 11 33078 2307 90593051
Catheter site bruise 17.65 11.94 7 33082 577 90594781
Asthma 17.53 11.94 39 33050 242121 90353237
Hydrops foetalis 17.33 11.94 7 33082 606 90594752
Intestinal diaphragm disease 17.28 11.94 5 33084 156 90595202
Varicella zoster virus infection 17.24 11.94 13 33076 3864 90591494
Infection reactivation 17.18 11.94 10 33079 1930 90593428
Depressed level of consciousness 17.12 11.94 62 33027 72722 90522636
Superinfection bacterial 16.90 11.94 8 33081 1014 90594344
Serum ferritin decreased 16.85 11.94 11 33078 2603 90592755
Liver disorder 16.75 11.94 88 33001 121181 90474177
Neuralgia 16.59 11.94 36 33053 31464 90563894
Hypoaesthesia 16.54 11.94 59 33030 314151 90281207
Pharyngeal haematoma 16.41 11.94 4 33085 63 90595295
Therapeutic response unexpected 16.39 11.94 29 33060 21851 90573507
Nerve degeneration 16.07 11.94 4 33085 69 90595289
Delirium 16.01 11.94 78 33011 104281 90491077
Hospitalisation 15.90 11.94 14 33075 128086 90467272
Constipation 15.88 11.94 51 33038 280344 90315014
Congenital hydrocephalus 15.80 11.94 5 33084 212 90595146
Infective myositis 15.76 11.94 4 33085 75 90595283
Frequent bowel movements 15.57 11.94 51 33038 56884 90538474
Febrile neutropenia 15.57 11.94 21 33068 158328 90437030
Cerebral vasoconstriction 15.47 11.94 8 33081 1226 90594132
Malignant neoplasm progression 15.42 11.94 10 33079 106860 90488498
Benign vaginal neoplasm 15.20 11.94 4 33085 87 90595271
Dislocation of vertebra 15.19 11.94 50 33039 55918 90539440
Necrotising enterocolitis neonatal 15.19 11.94 5 33084 241 90595117
Anaemia 14.98 11.94 72 33017 352730 90242628
Inflammation 14.93 11.94 114 32975 178478 90416880
Polyarthritis 14.63 11.94 25 33064 18325 90577033
Weight fluctuation 14.56 11.94 26 33063 19723 90575635
Mycobacterium tuberculosis complex test positive 14.46 11.94 10 33079 2602 90592756
Oligoarthritis 14.40 11.94 6 33083 562 90594796
External ear cellulitis 14.36 11.94 5 33084 286 90595072
Rectal haemorrhage 14.27 11.94 64 33025 82680 90512678
Medication error 14.25 11.94 65 33024 84587 90510771
Intentional underdose 14.14 11.94 9 33080 2040 90593318
Hypotension 14.05 11.94 66 33023 325331 90270027
Ankle fracture 13.98 11.94 26 33063 20344 90575014
Muscle spasticity 13.86 11.94 36 33053 35286 90560072
White blood cell analysis abnormal 13.85 11.94 3 33086 27 90595331
Narcolepsy 13.84 11.94 8 33081 1524 90593834
Myoclonus 13.83 11.94 25 33064 19143 90576215
Peripheral venous disease 13.80 11.94 64 33025 83857 90511501
Mental disorder 13.79 11.94 34 33055 32284 90563074
Cyst 13.78 11.94 23 33066 16538 90578820
Graft versus host disease in gastrointestinal tract 13.77 11.94 12 33077 4376 90590982
Meningomyelocele 13.69 11.94 6 33083 636 90594722
Impaired work ability 13.69 11.94 25 33064 19301 90576057
Visceral leishmaniasis 13.63 11.94 6 33083 643 90594715
Skin striae 13.56 11.94 8 33081 1583 90593775
Gastrooesophageal reflux disease 13.56 11.94 25 33064 166312 90429046
Blood pressure fluctuation 13.49 11.94 46 33043 52367 90542991
Fine motor skill dysfunction 13.45 11.94 13 33076 5406 90589952
Chronic gastritis 13.31 11.94 11 33078 3730 90591628
Product dose omission issue 13.29 11.94 58 33031 291629 90303729
Decreased vibratory sense 13.26 11.94 5 33084 360 90594998
Corneal neovascularisation 13.19 11.94 4 33085 147 90595211
Fibromyalgia 13.18 11.94 124 32965 206145 90389213
Hirsutism 13.03 11.94 8 33081 1702 90593656
Acute graft versus host disease in skin 12.94 11.94 12 33077 4744 90590614
Osteopenia 12.94 11.94 27 33062 22975 90572383
Episcleritis 12.89 11.94 7 33082 1183 90594175
Wrong technique in product usage process 12.87 11.94 5 33084 71566 90523792
Muscular weakness 12.84 11.94 36 33053 206630 90388728
Injection site reaction 12.77 11.94 9 33080 92071 90503287
Mydriasis 12.69 11.94 21 33068 14991 90580367
Nail disorder 12.65 11.94 3 33086 59064 90536294
Ductus arteriosus premature closure 12.53 11.94 5 33084 419 90594939
Musculoskeletal pain 12.51 11.94 106 32983 171145 90424213
Joint stiffness 12.45 11.94 59 33030 77983 90517375
Arthropod sting 12.33 11.94 7 33082 1290 90594068
Right ventricular hypertrophy 12.31 11.94 6 33083 811 90594547
Wound 12.19 11.94 63 33026 302917 90292441
Product quality issue 12.03 11.94 7 33082 79318 90516040

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ankylosing spondylitis 181.29 12.94 75 15336 6981 42598943
Ductus arteriosus premature closure 98.90 12.94 22 15389 229 42605695
Arthralgia 56.77 12.94 183 15228 205055 42400869
Hepatitis B virus test positive 56.76 12.94 15 15396 335 42605589
Tendon disorder 48.64 12.94 24 15387 3365 42602559
Gout 46.50 12.94 54 15357 28001 42577923
Sacroiliitis 44.00 12.94 19 15392 1963 42603961
Hypertensive encephalopathy 43.24 12.94 13 15398 469 42605455
Premature baby 42.51 12.94 47 15364 23106 42582818
Arthritis 41.82 12.94 63 15348 42002 42563922
Ankle fracture 40.49 12.94 24 15387 4842 42601082
Exostosis 39.75 12.94 25 15386 5606 42600318
Gastrointestinal haemorrhage 38.46 12.94 99 15312 97627 42508297
Drug ineffective 36.91 12.94 368 15043 629829 41976095
Hypoaldosteronism 34.65 12.94 10 15401 312 42605612
Mast cell activation syndrome 34.17 12.94 10 15401 328 42605596
Duodenal perforation 34.01 12.94 15 15396 1631 42604293
Joint swelling 33.30 12.94 75 15336 67947 42537977
Psoriatic arthropathy 33.19 12.94 43 15368 24924 42581000
Chest expansion decreased 31.85 12.94 8 15403 145 42605779
Musculoskeletal stiffness 30.89 12.94 66 15345 57699 42548225
Benign abdominal neoplasm 30.18 12.94 7 15404 89 42605835
Psoriasis 30.09 12.94 59 15352 48545 42557379
Drug hypersensitivity 29.58 12.94 91 15320 99298 42506626
Glomerulonephritis membranous 29.18 12.94 13 15398 1447 42604477
Gastric haemorrhage 27.81 12.94 26 15385 10489 42595435
Synovitis 27.54 12.94 31 15380 15536 42590388
Neck pain 27.09 12.94 43 15368 29971 42575953
Death 26.51 12.94 85 15326 471100 42134824
Neonatal disorder 25.64 12.94 10 15401 797 42605127
Axial spondyloarthritis 25.59 12.94 9 15402 536 42605388
Xanthelasma 25.01 12.94 6 15405 89 42605835
Osteoarthritis 24.89 12.94 37 15374 24368 42581556
Gouty arthritis 24.76 12.94 11 15400 1216 42604708
Foot fracture 23.88 12.94 19 15392 6172 42599752
Back pain 23.85 12.94 108 15303 141668 42464256
Placental transfusion syndrome 23.31 12.94 4 15407 8 42605916
Coarctation of the aorta 22.90 12.94 8 15403 467 42605457
Melaena 22.73 12.94 46 15365 38700 42567224
Foot deformity 22.71 12.94 17 15394 5051 42600873
Renal vein thrombosis 22.63 12.94 8 15403 484 42605440
Chronic idiopathic pain syndrome 22.21 12.94 6 15405 146 42605778
Sensitivity to weather change 22.20 12.94 12 15399 2031 42603893
Gastric ulcer 22.03 12.94 30 15381 18232 42587692
Caesarean section 21.85 12.94 12 15399 2094 42603830
Pain 21.63 12.94 157 15254 244691 42361233
Cross sensitivity reaction 21.50 12.94 11 15400 1664 42604260
Water intoxication 19.97 12.94 7 15404 413 42605511
Neonatal respiratory distress syndrome 19.91 12.94 15 15396 4498 42601426
Juvenile idiopathic arthritis 19.34 12.94 12 15399 2627 42603297
Venous thrombosis 19.12 12.94 14 15397 4021 42601903
Enthesopathy 19.02 12.94 15 15396 4813 42601111
Impatience 19.00 12.94 7 15404 477 42605447
Gastric bypass 18.45 12.94 6 15405 281 42605643
Spinal deformity 18.24 12.94 7 15404 534 42605390
Duodenal ulcer 17.66 12.94 22 15389 12257 42593667
Osteopenia 17.52 12.94 16 15395 6262 42599662
Gastrointestinal ulcer 17.52 12.94 10 15401 1880 42604044
Myofascial pain syndrome 17.00 12.94 6 15405 361 42605563
Joint range of motion decreased 16.45 12.94 17 15394 7736 42598188
Patent ductus arteriosus 16.34 12.94 12 15399 3464 42602460
Stillbirth 16.21 12.94 5 15406 197 42605727
Erythroblast count increased 15.95 12.94 3 15408 12 42605912
Gastritis 15.95 12.94 30 15381 23917 42582007
Pain in extremity 15.92 12.94 101 15310 150503 42455421
Neutropenia 15.86 12.94 30 15381 199401 42406523
Diabetic wound 15.70 12.94 4 15407 77 42605847
Foetal exposure during pregnancy 15.66 12.94 45 15366 47266 42558658
Pulmonary sarcoidosis 15.60 12.94 7 15404 793 42605131
Thoracic vertebral fracture 15.52 12.94 10 15401 2338 42603586
Procedural vomiting 15.48 12.94 5 15406 229 42605695
Intracranial pressure increased 15.22 12.94 13 15398 4661 42601263
Large intestinal ulcer 15.08 12.94 10 15401 2453 42603471
Faeces discoloured 14.83 12.94 24 15387 16990 42588934
Hydrops foetalis 14.77 12.94 7 15404 898 42605026
Drug tolerance 14.66 12.94 11 15400 3279 42602645
Sinus pain 14.60 12.94 7 15404 922 42605002
Tricuspid valve incompetence 14.54 12.94 19 15392 11094 42594830
Sinusitis aspergillus 14.41 12.94 4 15407 108 42605816
Malignant neoplasm progression 14.24 12.94 11 15400 108389 42497535
Oromandibular dystonia 13.99 12.94 6 15405 610 42605314
Tobacco abuse 13.95 12.94 6 15405 614 42605310
Dysstasia 13.85 12.94 21 15390 14065 42591859
Cardiomegaly 13.74 12.94 23 15388 16743 42589181
Iridocyclitis 13.59 12.94 9 15402 2202 42603722
Blood pressure fluctuation 13.52 12.94 30 15381 26878 42579046
Intraventricular haemorrhage neonatal 13.21 12.94 5 15406 367 42605557
Fibula fracture 13.15 12.94 7 15404 1149 42604775
Purulent pericarditis 13.10 12.94 3 15408 36 42605888
Foetal distress syndrome 12.98 12.94 7 15404 1179 42604745

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ankylosing spondylitis 302.01 11.57 139 43016 15473 110530671
Drug ineffective for unapproved indication 222.70 11.57 236 42919 102602 110443542
Swollen tongue 191.79 11.57 171 42984 60191 110485953
Angioedema 180.29 11.57 207 42948 98293 110447851
Dysphonia 167.46 11.57 176 42979 75753 110470391
Swelling face 153.96 11.57 185 42970 92136 110454008
Neck deformity 144.98 11.57 46 43109 1840 110544304
Neck mass 112.64 11.57 49 43106 4772 110541372
Oesophageal spasm 104.79 11.57 43 43112 3623 110542521
Drug intolerance 99.13 11.57 366 42789 406146 110139998
Bone density abnormal 95.55 11.57 41 43114 3862 110542282
Oesophageal pain 87.89 11.57 42 43113 5083 110541061
Drug ineffective 80.35 11.57 925 42230 1519615 109026529
Musculoskeletal stiffness 71.57 11.57 256 42899 279566 110266578
Death 68.79 11.57 104 43051 698765 109847379
Porphyria acute 67.28 11.57 57 43098 18723 110527421
Corneal perforation 56.06 11.57 19 43136 937 110545207
Hypersensitivity 54.18 11.57 305 42850 403693 110142451
Sacroiliitis 54.07 11.57 30 43125 4948 110541196
Mood swings 52.27 11.57 54 43101 22758 110523386
Chronic idiopathic pain syndrome 51.66 11.57 13 43142 219 110545925
Headache 51.46 11.57 548 42607 881829 109664315
Lymphoedema 50.81 11.57 44 43111 14885 110531259
Arthralgia 50.61 11.57 495 42660 779137 109767007
Hepatitis B virus test positive 49.36 11.57 15 43140 519 110545625
Ankle fracture 45.57 11.57 47 43108 19772 110526372
Neutropenia 41.59 11.57 51 43104 374569 110171575
Back pain 40.76 11.57 266 42889 370730 110175414
Hypermobility syndrome 40.34 11.57 13 43142 547 110545597
Joint swelling 39.03 11.57 301 42854 442544 110103600
Disability 38.46 11.57 53 43102 30170 110515974
Actinomycotic sepsis 38.13 11.57 10 43145 200 110545944
Tinnitus 36.46 11.57 76 43079 60464 110485680
Amaurosis fugax 36.22 11.57 18 43137 2372 110543772
Glomerulonephritis membranous 36.14 11.57 17 43138 1986 110544158
Sleep apnoea syndrome 35.93 11.57 60 43095 40387 110505757
Serotonin syndrome 35.32 11.57 74 43081 59079 110487065
X-ray abnormal 34.47 11.57 57 43098 38060 110508084
Limb deformity 33.79 11.57 20 43135 3726 110542418
Premature delivery 33.52 11.57 50 43105 30582 110515562
Tendon disorder 33.40 11.57 27 43128 8310 110537834
Malignant neoplasm progression 32.00 11.57 14 43141 174553 110371591
Nephropathy toxic 31.73 11.57 46 43109 27432 110518712
Arthritis 29.77 11.57 137 43018 167449 110378695
Night sweats 29.57 11.57 117 43038 133866 110412278
Tendonitis 29.15 11.57 43 43112 26040 110520104
Herpes zoster infection neurological 29.10 11.57 10 43145 514 110545630
Hypotension 28.92 11.57 106 43049 523743 110022401
Allergic sinusitis 28.74 11.57 14 43141 1767 110544377
Drug hypersensitivity 28.73 11.57 287 42868 453803 110092341
Chest expansion decreased 28.66 11.57 8 43147 204 110545940
Blood pressure diastolic increased 27.02 11.57 35 43120 18772 110527372
Synovial disorder 26.98 11.57 16 43139 2991 110543153
Pain 26.84 11.57 522 42633 954433 109591711
Hypoaldosteronism 26.72 11.57 10 43145 659 110545485
Intestinal diaphragm disease 26.30 11.57 9 43146 457 110545687
Large intestinal ulcer 25.97 11.57 20 43135 5741 110540403
Antinuclear antibody positive 25.26 11.57 24 43131 9144 110537000
Gastrointestinal haemorrhage 24.88 11.57 129 43026 165389 110380755
Fibromyalgia 24.86 11.57 132 43023 170777 110375367
Investigation abnormal 24.50 11.57 14 43141 2442 110543702
Gastric ulcer 23.98 11.57 50 43105 39777 110506367
Osteoarthritis 23.86 11.57 137 43018 182486 110363658
Ductus arteriosus premature closure 23.74 11.57 6 43149 103 110546041
Right ventricular hypertension 23.73 11.57 4 43151 6 110546138
Focal nodular hyperplasia 23.70 11.57 10 43145 903 110545241
Product dose omission issue 23.60 11.57 57 43098 321725 110224419
Gastric haemorrhage 23.47 11.57 30 43125 15885 110530259
Psoriatic arthropathy 23.39 11.57 144 43011 196617 110349527
Uveitis 23.13 11.57 35 43120 21675 110524469
Dislocation of vertebra 23.03 11.57 52 43103 43669 110502475
Dysstasia 22.97 11.57 44 43111 32942 110513202
Joint abscess 22.72 11.57 9 43146 692 110545452
Cellulitis staphylococcal 22.55 11.57 11 43144 1392 110544752
Vascular rupture 22.48 11.57 12 43143 1834 110544310
Blood pressure fluctuation 22.20 11.57 72 43083 74752 110471392
Gout 22.13 11.57 46 43109 36520 110509624
Treatment failure 21.97 11.57 184 42971 277050 110269094
Apallic syndrome 21.86 11.57 10 43145 1096 110545048
Benign abdominal neoplasm 21.31 11.57 7 43148 313 110545831
Musculoskeletal pain 21.16 11.57 133 43022 182890 110363254
Xanthelasma 21.13 11.57 6 43149 163 110545981
Atrial fibrillation 20.82 11.57 36 43119 229606 110316538
Duodenal perforation 20.42 11.57 13 43142 2757 110543387
Neonatal disorder 19.92 11.57 4 43151 22 110546122
Joint effusion 19.90 11.57 32 43123 20873 110525271
Osteopenia 19.80 11.57 33 43122 22176 110523968
Feeling hot 19.65 11.57 79 43076 91027 110455117
Secondary adrenocortical insufficiency 19.13 11.57 15 43140 4419 110541725
Myocardial infarction 18.84 11.57 134 43021 191949 110354195
Rheumatoid factor positive 18.68 11.57 101 43054 131539 110414605
Medication overuse headache 18.58 11.57 10 43145 1553 110544591
Liver disorder 18.11 11.57 106 43049 142137 110404007
Hyponatraemia 18.06 11.57 36 43119 217617 110328527
Gouty arthritis 18.02 11.57 10 43145 1649 110544495
Adrenal suppression 17.82 11.57 10 43145 1686 110544458
Right ventricular hypertrophy 17.69 11.57 10 43145 1709 110544435
Axial spondyloarthritis 17.55 11.57 8 43147 870 110545274
Duodenal ulcer 17.40 11.57 29 43126 19485 110526659
Exposure during pregnancy 17.13 11.57 118 43037 167306 110378838
Catheter site bruise 17.12 11.57 7 43148 584 110545560
Joint range of motion decreased 16.97 11.57 93 43062 121739 110424405
Vitamin B12 decreased 16.90 11.57 15 43140 5242 110540902
Large intestinal ulcer haemorrhage 16.85 11.57 6 43149 343 110545801
Head discomfort 16.63 11.57 28 43127 18972 110527172
Colitis ulcerative 16.62 11.57 67 43088 77296 110468848
Neuralgia 16.56 11.57 49 43106 48429 110497715
Neck pain 16.49 11.57 93 43062 123037 110423107
Coccydynia 16.46 11.57 11 43144 2530 110543614
Anaemia 16.23 11.57 136 43019 546950 109999194
Hypoxia 16.15 11.57 16 43139 129499 110416645
Enthesopathy 16.05 11.57 22 43133 12456 110533688
Stress 15.75 11.57 82 43073 105266 110440878
Cytokine release syndrome 15.74 11.57 4 43151 70302 110475842
Pharyngitis 15.69 11.57 32 43123 25066 110521078
Renal vein thrombosis 15.66 11.57 8 43147 1117 110545027
Diabetic wound 15.60 11.57 4 43151 73 110546071
Urinary tract disorder 15.54 11.57 15 43140 5829 110540315
Neuropathy peripheral 15.44 11.57 29 43126 179248 110366896
Benign vaginal neoplasm 15.30 11.57 4 43151 79 110546065
Oligoarthritis 15.24 11.57 7 43148 774 110545370
Blood iron decreased 15.10 11.57 27 43128 19187 110526957
Vision blurred 15.06 11.57 94 43061 128928 110417216
Joint stiffness 15.06 11.57 59 43096 67184 110478960
Impatience 14.97 11.57 7 43148 807 110545337
Episcleritis 14.77 11.57 8 43147 1258 110544886
Wrong technique in product usage process 14.50 11.57 8 43147 87340 110458804
Insomnia 14.45 11.57 209 42946 360381 110185763
Endothelin increased 14.32 11.57 3 43152 21 110546123
Venous thrombosis 14.09 11.57 17 43138 8488 110537656
Growth retardation 13.96 11.57 10 43145 2572 110543572
Water intoxication 13.88 11.57 7 43148 952 110545192
Inflammation 13.61 11.57 125 43030 193113 110353031
Asthma 13.56 11.57 51 43104 250240 110295904
Nail disorder 13.55 11.57 3 43152 57932 110488212
Cerebral vasoconstriction 13.50 11.57 8 43147 1493 110544651
Constipation 13.49 11.57 83 43072 357703 110188441
Trigger finger 13.41 11.57 13 43142 5079 110541065
Gastrointestinal ulcer 13.38 11.57 12 43143 4248 110541896
Juvenile idiopathic arthritis 13.37 11.57 14 43141 5993 110540151
Lactic acidosis 13.36 11.57 10 43145 92801 110453343
Therapeutic product effect decreased 13.35 11.57 150 43005 244166 110301978
Psoriasis 13.34 11.57 97 43058 139896 110406248
Depressed level of consciousness 13.23 11.57 82 43073 112196 110433948
Hospitalisation 13.22 11.57 22 43133 142471 110403673
Muscular weakness 13.22 11.57 51 43104 248417 110297727
Dizziness 13.13 11.57 361 42794 697832 109848312
Hyperhidrosis 13.11 11.57 121 43034 187177 110358967
Overdose 13.08 11.57 47 43108 233747 110312397
Mental disorder 13.05 11.57 39 43116 38752 110507392
Disease progression 13.04 11.57 50 43105 243984 110302160
Ear pain 12.99 11.57 48 43107 53178 110492966
Prescribed overdose 12.97 11.57 68 43087 87513 110458631
Dyspnoea 12.96 11.57 331 42824 1106541 109439603
Peripheral venous disease 12.94 11.57 66 43089 84051 110462093
Migraine 12.58 11.57 112 43043 171540 110374604
White blood cell analysis abnormal 12.58 11.57 3 43152 40 110546104
Vitiligo 12.57 11.57 10 43145 3007 110543137
Blepharospasm 12.51 11.57 3 43152 54848 110491296
Generalised tonic-clonic seizure 12.46 11.57 3 43152 54677 110491467
Pharyngeal haematoma 12.42 11.57 4 43151 168 110545976
Weight fluctuation 12.41 11.57 27 43128 22118 110524026
Cytomegalovirus infection 12.38 11.57 3 43152 54441 110491703
Wound infection 12.35 11.57 72 43083 96393 110449751
Arthritis bacterial 12.32 11.57 18 43137 10802 110535342
Hirsutism 12.32 11.57 8 43147 1755 110544389
Neoplasm progression 12.12 11.57 5 43150 64590 110481554
Urticaria 12.06 11.57 183 42972 318674 110227470
Oligohydramnios 12.06 11.57 11 43144 3983 110542161
Leukopenia 12.01 11.57 25 43130 148766 110397378
Muscle spasticity 11.98 11.57 36 43119 35879 110510265
COVID-19 11.97 11.57 52 43103 245008 110301136
Depression 11.96 11.57 182 42973 317153 110228991
Myoclonus 11.89 11.57 34 43121 32964 110513180
Pain in extremity 11.89 11.57 261 42894 486857 110059287
Synovitis 11.84 11.57 161 42994 273931 110272213
Mycobacterium tuberculosis complex test positive 11.82 11.57 10 43145 3278 110542866
Intentional underdose 11.81 11.57 9 43146 2543 110543601
Epilepsy 11.80 11.57 13 43142 100196 110445948

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01EB03 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
OTHER CARDIAC PREPARATIONS
Other cardiac preparations
ATC M01AB01 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
ATC M01AB51 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
ATC M02AA23 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
ATC S01BC01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Antiinflammatory agents, non-steroids
ATC S01CC02 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Antiinflammatory agents, non-steroids and antiinfectives in combination
FDA CS M0001335 Anti-Inflammatory Agents, Non-Steroidal
FDA MoA N0000000160 Cyclooxygenase Inhibitors
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D006074 Gout Suppressants
MeSH PA D012102 Reproductive Control Agents
MeSH PA D015149 Tocolytic Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35544 EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:35845 gout suppressant
CHEBI has role CHEBI:49103 drug metabolite
CHEBI has role CHEBI:50514 vasoconstrictor agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:76206 xenobiotic metabolite
CHEBI has role CHEBI:78298 environmental contaminant

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S01CC Antiinflammatory agents, non-steroids and antiinfectives in combination 1 drug
diclofenac

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Tendinitis indication 34840004 DOID:971
Tenosynovitis indication 67801009 DOID:970
Rheumatoid arthritis indication 69896004 DOID:7148
Patent ductus arteriosus indication 83330001 DOID:13832
Bursitis indication 84017003 DOID:2965
Gout indication 90560007 DOID:13189
Bursitis of shoulder indication 239961006
Osteoarthritis indication 396275006
Synovitis indication 416209007 DOID:2703
Shoulder Tendonitis indication
Pericarditis off-label use 3238004 DOID:1787
Premature labor off-label use 6383007
Renal colic off-label use 7093002
Pseudoprimary hyperaldosteronism off-label use 71275003
Nephrogenic diabetes insipidus off-label use 111395007 DOID:12387
Dysmenorrhea off-label use 266599000
Fever off-label use 386661006
Twin reversal arterial perfusion syndrome off-label use 417006004
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Proctitis contraindication 3951002 DOID:3127
Acute hemorrhage contraindication 8573003
Rectal hemorrhage contraindication 12063002
Hyperkalemia contraindication 14140009
Myocardial infarction contraindication 22298006 DOID:5844
Parkinsonism contraindication 32798002
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Duodenal ulcer disease contraindication 51868009 DOID:1724
Gastrointestinal perforation contraindication 51875005
Stomatitis contraindication 61170000 DOID:9637
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Hemorrhoids contraindication 70153002 DOID:9746
Corneal deposit contraindication 74460005 DOID:11547
Gastrointestinal hemorrhage contraindication 74474003
Heart failure contraindication 84114007 DOID:6000
Epilepsy contraindication 84757009 DOID:1826
Bacterial infectious disease contraindication 87628006
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Blurring of visual image contraindication 111516008
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Asthma contraindication 195967001 DOID:2841
Sepsis of the newborn contraindication 206376005
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Esophageal dysmotility contraindication 266434009 DOID:9192
Cerebral hemorrhage contraindication 274100004
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Malignant tumor of colon contraindication 363406005 DOID:219
Cardiovascular event risk contraindication 395112001
Gastric ulcer contraindication 397825006 DOID:10808
Diverticular disease contraindication 397881000
Smokes tobacco daily contraindication 449868002
Psychiatric Disturbance contraindication
Intraventricular Hemorrhage In Newborn contraindication
Congenital Heart Defect Requiring Open Patent Ductus Arteriosus contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.45 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
20MG TIVORBEX GENUS N204768 Feb. 24, 2014 DISCN CAPSULE ORAL 9089471 April 23, 2030 TREATMENT OF PAIN
40MG TIVORBEX GENUS N204768 Feb. 24, 2014 DISCN CAPSULE ORAL 9089471 April 23, 2030 TREATMENT OF PAIN

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 7.21 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 6.33 WOMBAT-PK CHEMBL
Multidrug resistance protein 1 Transporter IC50 4.49 CHEMBL
Multidrug resistance-associated protein 1 Transporter IC50 4.92 CHEMBL
Androgen receptor Nuclear hormone receptor EC50 9.85 CHEMBL
Prostaglandin D2 receptor 2 GPCR Ki 6.53 WOMBAT-PK
Dehydrogenase/reductase SDR family member 9 Enzyme IC50 4.85 CHEMBL
Xanthine dehydrogenase/oxidase Enzyme IC50 4.07 CHEMBL
Aldose reductase Enzyme IC50 5.22 CHEMBL
Aldo-keto reductase family 1 member C2 Enzyme IC50 4.44 CHEMBL
Aldo-keto reductase family 1 member C3 Enzyme IC50 7 CHEMBL
Prostaglandin E2 receptor EP2 subtype GPCR Ki 7.69 PDSP
Cytochrome c oxidase subunit 2 Enzyme IC50 6.21 CHEMBL
Interleukin-8 Cytokine IC50 7.30 CHEMBL
Potassium voltage-gated channel subfamily A member 7 Ion channel Ki 7.50 WOMBAT-PK
Prostaglandin E synthase Enzyme IC50 4.39 CHEMBL
Aldo-keto reductase family 1 member C4 Enzyme IC50 4.27 CHEMBL
Lactoylglutathione lyase Enzyme Ki 4.74 CHEMBL
Nicotinate phosphoribosyltransferase Enzyme Ki 9.82 CHEMBL
Peroxisome proliferator-activated receptor gamma Nuclear hormone receptor AGONIST Kd 7.38 IUPHAR
Aldose reductase Enzyme IC50 5.44 DRUG MATRIX
Prostaglandin G/H synthase 2 Enzyme IC50 8.19 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 8.70 CHEMBL
Aldose reductase Enzyme IC50 5.30 CHEMBL
Prostaglandin G/H synthase 1 Enzyme Ki 5.10 CHEMBL
Prostaglandin-H2 D-isomerase Enzyme IC50 6.30 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 8 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 8.22 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 6.47 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 8.39 CHEMBL
Cyclooxygenase Enzyme IC50 6.37 CHEMBL
Cyclooxygenase Enzyme IC50 7 CHEMBL
Prostaglandin G/H synthase (cyclooxygenase) Enzyme IC50 6.82 CHEMBL
Nitric oxide synthase, inducible Enzyme IC50 4.70 CHEMBL
Prostaglandin D2 receptor 2 GPCR AGONIST Ki 6 IUPHAR

External reference:

IDSource
D00141 KEGG_DRUG
4017890 VANDF
4017891 VANDF
C0021246 UMLSCUI
CHEBI:49662 CHEBI
IMN PDB_CHEM_ID
CHEMBL6 ChEMBL_ID
CHEMBL3989410 ChEMBL_ID
DB00328 DRUGBANK_ID
D007213 MESH_DESCRIPTOR_UI
3715 PUBCHEM_CID
1909 IUPHAR_LIGAND_ID
1524 INN_ID
74252-25-8 SECONDARY_CAS_RN
XXE1CET956 UNII
1294612 RXNORM
2387 MMSL
2393 MMSL
4877 MMSL
d00039 MMSL
002373 NDDF
002374 NDDF
373513008 SNOMEDCT_US
60149003 SNOMEDCT_US
783274005 SNOMEDCT_US
XXE1CET956 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
INDOMETHACIN HUMAN PRESCRIPTION DRUG LABEL 1 0054-1950 SUPPOSITORY 50 mg RECTAL ANDA 29 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-083 CAPSULE 50 mg ORAL ANDA 27 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-919 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 12 sections
Indomethacin Human Prescription Drug Label 1 10544-935 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 24 sections
INDOMETHACIN HUMAN PRESCRIPTION DRUG LABEL 1 10702-016 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 29 sections
INDOMETHACIN ER HUMAN PRESCRIPTION DRUG LABEL 1 12634-160 CAPSULE 75 mg ORAL ANDA 14 sections
INDOMETHACIN ER HUMAN PRESCRIPTION DRUG LABEL 1 12634-838 CAPSULE 75 mg ORAL ANDA 14 sections
INDOMETHACIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-130 CAPSULE 50 mg ORAL ANDA 24 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 21695-522 CAPSULE 25 mg ORAL ANDA 27 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 21695-523 CAPSULE 50 mg ORAL ANDA 23 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 31722-051 SUPPOSITORY 50 mg RECTAL ANDA 27 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 31722-542 CAPSULE 25 mg ORAL ANDA 27 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 31722-543 CAPSULE 50 mg ORAL ANDA 27 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 31722-565 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 27 sections
INDOCIN HUMAN PRESCRIPTION DRUG LABEL 1 42211-101 SUSPENSION 25 mg ORAL NDA 28 sections
Tivorbex HUMAN PRESCRIPTION DRUG LABEL 1 42211-201 CAPSULE 20 mg ORAL NDA 28 sections
Tivorbex HUMAN PRESCRIPTION DRUG LABEL 1 42211-202 CAPSULE 40 mg ORAL NDA 28 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 42254-081 CAPSULE 50 mg ORAL ANDA 27 sections
INDOMETHACIN HUMAN PRESCRIPTION DRUG LABEL 1 42254-237 CAPSULE 25 mg ORAL ANDA 25 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 43063-368 CAPSULE 25 mg ORAL ANDA 28 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 43063-368 CAPSULE 25 mg ORAL ANDA 28 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 43063-773 CAPSULE 25 mg ORAL ANDA 27 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 43063-777 CAPSULE 50 mg ORAL ANDA 27 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 43063-929 CAPSULE 50 mg ORAL ANDA 28 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 43063-929 CAPSULE 50 mg ORAL ANDA 28 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 43063-930 CAPSULE 50 mg ORAL ANDA 28 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 43063-930 CAPSULE 50 mg ORAL ANDA 28 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 49349-776 CAPSULE 50 mg ORAL ANDA 24 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 50090-0050 CAPSULE 50 mg ORAL ANDA 27 sections
Indomethacin HUMAN PRESCRIPTION DRUG LABEL 1 50090-0050 CAPSULE 50 mg ORAL ANDA 27 sections