Stem definition | Drug id | CAS RN |
---|---|---|
angiotensin-converting enzyme inhibitors | 1587 | 76547-98-3 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 97 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 94 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.41 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 25 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.89 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 42 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 29, 1987 | FDA | MERCK |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Angioedema | 1650.09 | 9.59 | 1441 | 254424 | 46524 | 63186633 |
Intestinal angioedema | 629.50 | 9.59 | 191 | 255674 | 464 | 63232693 |
Cardiac failure congestive | 570.60 | 9.59 | 1194 | 254671 | 91239 | 63141918 |
Myocardial infarction | 495.96 | 9.59 | 1183 | 254682 | 98710 | 63134447 |
Swollen tongue | 339.43 | 9.59 | 548 | 255317 | 34252 | 63198905 |
Drug ineffective | 320.76 | 9.59 | 2688 | 253177 | 1042077 | 62191080 |
Cerebrovascular accident | 308.75 | 9.59 | 1048 | 254817 | 106976 | 63126181 |
Off label use | 248.77 | 9.59 | 1646 | 254219 | 672816 | 62560341 |
Acute kidney injury | 236.45 | 9.59 | 1843 | 254022 | 261572 | 62971585 |
Coronary artery disease | 232.85 | 9.59 | 446 | 255419 | 31931 | 63201226 |
Completed suicide | 213.62 | 9.59 | 1154 | 254711 | 144519 | 63088638 |
Pyrexia | 188.68 | 9.59 | 1118 | 254747 | 469360 | 62763797 |
Maternal exposure during pregnancy | 169.64 | 9.59 | 399 | 255466 | 219663 | 63013494 |
Lip swelling | 153.03 | 9.59 | 367 | 255498 | 30696 | 63202461 |
Drug hypersensitivity | 152.93 | 9.59 | 1918 | 253947 | 308769 | 62924388 |
Drug abuse | 145.50 | 9.59 | 55 | 255810 | 72463 | 63160694 |
Contraindicated product administered | 140.28 | 9.59 | 431 | 255434 | 217217 | 63015940 |
Acute myocardial infarction | 138.77 | 9.59 | 361 | 255504 | 31763 | 63201394 |
Febrile neutropenia | 130.99 | 9.59 | 171 | 255694 | 118278 | 63114879 |
Hyperkalaemia | 130.99 | 9.59 | 498 | 255367 | 53705 | 63179452 |
Injury | 123.10 | 9.59 | 603 | 255262 | 72644 | 63160513 |
Exposure during pregnancy | 123.06 | 9.59 | 278 | 255587 | 155269 | 63077888 |
Blood glucose increased | 116.31 | 9.59 | 654 | 255211 | 83102 | 63150055 |
C-reactive protein increased | 112.87 | 9.59 | 129 | 255736 | 94578 | 63138579 |
Neutropenia | 104.77 | 9.59 | 358 | 255507 | 174647 | 63058510 |
Drug intolerance | 104.09 | 9.59 | 772 | 255093 | 307889 | 62925268 |
Lactic acidosis | 102.79 | 9.59 | 364 | 255501 | 37923 | 63195234 |
Infusion related reaction | 101.61 | 9.59 | 577 | 255288 | 244944 | 62988213 |
Type 2 diabetes mellitus | 99.71 | 9.59 | 515 | 255350 | 63353 | 63169804 |
Renal failure | 94.94 | 9.59 | 804 | 255061 | 116848 | 63116309 |
Systemic lupus erythematosus | 94.75 | 9.59 | 476 | 255389 | 208442 | 63024715 |
Abortion spontaneous | 94.32 | 9.59 | 36 | 255829 | 47159 | 63185998 |
Dehydration | 94.22 | 9.59 | 1091 | 254774 | 172263 | 63060894 |
Interstitial lung disease | 86.84 | 9.59 | 73 | 255792 | 61835 | 63171322 |
Pemphigus | 84.79 | 9.59 | 416 | 255449 | 183310 | 63049847 |
Synovitis | 84.68 | 9.59 | 426 | 255439 | 186492 | 63046665 |
Swelling face | 83.75 | 9.59 | 489 | 255376 | 62986 | 63170171 |
Dizziness | 82.80 | 9.59 | 2293 | 253572 | 427632 | 62805525 |
Psoriasis | 78.12 | 9.59 | 609 | 255256 | 86348 | 63146809 |
Diarrhoea | 76.76 | 9.59 | 3569 | 252296 | 711797 | 62521360 |
Premature delivery | 75.61 | 9.59 | 15 | 255850 | 30266 | 63202891 |
Blood cholesterol increased | 75.53 | 9.59 | 642 | 255223 | 93390 | 63139767 |
Labile blood pressure | 74.35 | 9.59 | 60 | 255805 | 1729 | 63231428 |
Hepatic function abnormal | 71.49 | 9.59 | 30 | 255835 | 37112 | 63196045 |
Therapeutic product effect incomplete | 71.36 | 9.59 | 261 | 255604 | 124795 | 63108362 |
Coronary arterial stent insertion | 70.27 | 9.59 | 71 | 255794 | 2758 | 63230399 |
Prescribed overdose | 69.11 | 9.59 | 297 | 255568 | 33856 | 63199301 |
Product dose omission issue | 69.08 | 9.59 | 1327 | 254538 | 232986 | 63000171 |
Hypotensive transfusion reaction | 68.35 | 9.59 | 19 | 255846 | 29 | 63233128 |
Hypovolaemia | 68.25 | 9.59 | 140 | 255725 | 10533 | 63222624 |
Chest pain | 68.14 | 9.59 | 1236 | 254629 | 214723 | 63018434 |
Lower respiratory tract infection | 67.93 | 9.59 | 288 | 255577 | 132019 | 63101138 |
Pancreatitis | 66.73 | 9.59 | 381 | 255484 | 48674 | 63184483 |
Coronary artery bypass | 65.43 | 9.59 | 63 | 255802 | 2306 | 63230851 |
Fibromyalgia | 64.55 | 9.59 | 549 | 255316 | 79871 | 63153286 |
Asthenia | 63.73 | 9.59 | 2009 | 253856 | 381595 | 62851562 |
Suspected suicide | 63.43 | 9.59 | 103 | 255762 | 6465 | 63226692 |
Myelosuppression | 62.97 | 9.59 | 10 | 255855 | 23693 | 63209464 |
Mental status changes | 62.97 | 9.59 | 321 | 255544 | 39278 | 63193879 |
Arthropathy | 59.35 | 9.59 | 632 | 255233 | 234160 | 62998997 |
Leukopenia | 58.79 | 9.59 | 141 | 255724 | 77149 | 63156008 |
Hepatotoxicity | 57.95 | 9.59 | 39 | 255826 | 37002 | 63196155 |
Sopor | 57.44 | 9.59 | 10 | 255855 | 22154 | 63211003 |
Oxygen saturation decreased | 57.30 | 9.59 | 175 | 255690 | 88410 | 63144747 |
Gastrointestinal haemorrhage | 56.86 | 9.59 | 538 | 255327 | 80638 | 63152519 |
Blood pressure inadequately controlled | 56.36 | 9.59 | 84 | 255781 | 4894 | 63228263 |
Cytomegalovirus infection | 55.30 | 9.59 | 9 | 255856 | 20943 | 63212214 |
Foetal exposure during pregnancy | 55.11 | 9.59 | 30 | 255835 | 31932 | 63201225 |
Chronic kidney disease | 54.32 | 9.59 | 341 | 255524 | 45057 | 63188100 |
Joint swelling | 53.72 | 9.59 | 963 | 254902 | 326703 | 62906454 |
Malignant neoplasm progression | 53.28 | 9.59 | 162 | 255703 | 81959 | 63151198 |
Adjustment disorder with depressed mood | 52.90 | 9.59 | 123 | 255742 | 10081 | 63223076 |
Overdose | 52.81 | 9.59 | 261 | 255604 | 114817 | 63118340 |
Glossodynia | 50.83 | 9.59 | 468 | 255397 | 178408 | 63054749 |
Intentional self-injury | 50.65 | 9.59 | 20 | 255845 | 25667 | 63207490 |
Infection | 50.48 | 9.59 | 636 | 255229 | 228537 | 63004620 |
Nausea | 50.26 | 9.59 | 4044 | 251821 | 850427 | 62382730 |
Angina unstable | 50.09 | 9.59 | 97 | 255768 | 6998 | 63226159 |
Depressed level of consciousness | 49.83 | 9.59 | 110 | 255755 | 61968 | 63171189 |
Grip strength decreased | 49.15 | 9.59 | 199 | 255666 | 22088 | 63211069 |
Arthralgia | 49.02 | 9.59 | 1840 | 254025 | 567870 | 62665287 |
Blood pressure increased | 48.12 | 9.59 | 919 | 254946 | 161143 | 63072014 |
Alopecia | 48.03 | 9.59 | 1016 | 254849 | 336520 | 62896637 |
Muscle spasms | 47.92 | 9.59 | 890 | 254975 | 155260 | 63077897 |
Agranulocytosis | 47.26 | 9.59 | 21 | 255844 | 25113 | 63208044 |
Hand deformity | 47.13 | 9.59 | 413 | 255452 | 159044 | 63074113 |
Oedema | 46.73 | 9.59 | 600 | 255265 | 97022 | 63136135 |
Blood pressure diastolic abnormal | 46.70 | 9.59 | 3 | 255862 | 14539 | 63218618 |
Thrombocytopenia | 46.24 | 9.59 | 388 | 255477 | 150769 | 63082388 |
Rheumatoid nodule | 46.11 | 9.59 | 7 | 255858 | 17148 | 63216009 |
Arterial occlusive disease | 45.21 | 9.59 | 84 | 255781 | 5874 | 63227283 |
Hypotension | 44.76 | 9.59 | 1426 | 254439 | 271178 | 62961979 |
Premature baby | 44.56 | 9.59 | 14 | 255851 | 20721 | 63212436 |
Treatment failure | 44.34 | 9.59 | 551 | 255314 | 198492 | 63034665 |
Mucosal inflammation | 43.86 | 9.59 | 76 | 255789 | 46852 | 63186305 |
Blood pressure fluctuation | 43.30 | 9.59 | 75 | 255790 | 46242 | 63186915 |
Hypertension | 43.27 | 9.59 | 1451 | 254414 | 277852 | 62955305 |
Sedation | 42.91 | 9.59 | 56 | 255809 | 38753 | 63194404 |
Pain | 42.88 | 9.59 | 2496 | 253369 | 738132 | 62495025 |
Hypercholesterolaemia | 42.76 | 9.59 | 185 | 255680 | 21149 | 63212008 |
Spinal stenosis | 42.75 | 9.59 | 145 | 255720 | 14780 | 63218377 |
Suicide attempt | 41.82 | 9.59 | 117 | 255748 | 60801 | 63172356 |
Memory impairment | 41.47 | 9.59 | 620 | 255245 | 103638 | 63129519 |
Dry mouth | 41.34 | 9.59 | 488 | 255377 | 77375 | 63155782 |
Facet joint syndrome | 41.20 | 9.59 | 125 | 255740 | 12013 | 63221144 |
Tenosynovitis | 41.07 | 9.59 | 4 | 255861 | 13791 | 63219366 |
Hypoaesthesia | 40.86 | 9.59 | 927 | 254938 | 167466 | 63065691 |
Product complaint | 40.78 | 9.59 | 129 | 255736 | 12680 | 63220477 |
Renal injury | 40.68 | 9.59 | 106 | 255759 | 9333 | 63223824 |
Glycosylated haemoglobin increased | 40.52 | 9.59 | 126 | 255739 | 12272 | 63220885 |
Liver injury | 40.36 | 9.59 | 397 | 255468 | 60123 | 63173034 |
Osteoarthritis | 40.29 | 9.59 | 573 | 255292 | 94770 | 63138387 |
Dislocation of vertebra | 39.31 | 9.59 | 99 | 255766 | 8536 | 63224621 |
Pneumocystis jirovecii pneumonia | 38.98 | 9.59 | 10 | 255855 | 16904 | 63216253 |
Lip dry | 38.91 | 9.59 | 144 | 255721 | 15326 | 63217831 |
Gangrene | 38.78 | 9.59 | 80 | 255785 | 6043 | 63227114 |
Atrioventricular block second degree | 38.64 | 9.59 | 62 | 255803 | 3852 | 63229305 |
Coma | 38.25 | 9.59 | 132 | 255733 | 64232 | 63168925 |
Altered state of consciousness | 37.58 | 9.59 | 28 | 255837 | 25202 | 63207955 |
Ischaemic cardiomyopathy | 37.36 | 9.59 | 48 | 255817 | 2429 | 63230728 |
Arteriosclerosis | 37.35 | 9.59 | 107 | 255758 | 9959 | 63223198 |
Peripheral venous disease | 37.21 | 9.59 | 142 | 255723 | 15335 | 63217822 |
Intentional overdose | 37.07 | 9.59 | 163 | 255702 | 73989 | 63159168 |
Blood pressure systolic abnormal | 37.06 | 9.59 | 5 | 255860 | 13381 | 63219776 |
Product use issue | 36.77 | 9.59 | 646 | 255219 | 219874 | 63013283 |
Blood sodium decreased | 36.76 | 9.59 | 194 | 255671 | 24058 | 63209099 |
Transient ischaemic attack | 36.47 | 9.59 | 269 | 255596 | 37484 | 63195673 |
Sedation complication | 36.34 | 9.59 | 6 | 255859 | 13816 | 63219341 |
Somatic delusion | 36.12 | 9.59 | 25 | 255840 | 567 | 63232590 |
Drug resistance | 36.07 | 9.59 | 24 | 255841 | 22909 | 63210248 |
Body temperature increased | 35.89 | 9.59 | 59 | 255806 | 37133 | 63196024 |
Hepatic cytolysis | 35.71 | 9.59 | 9 | 255856 | 15398 | 63217759 |
Pancreatitis acute | 35.64 | 9.59 | 209 | 255656 | 26957 | 63206200 |
Drug reaction with eosinophilia and systemic symptoms | 34.24 | 9.59 | 52 | 255813 | 33784 | 63199373 |
Cardiac disorder | 34.20 | 9.59 | 334 | 255531 | 50482 | 63182675 |
Atrial fibrillation | 34.13 | 9.59 | 660 | 255205 | 115976 | 63117181 |
Hepatic ischaemia | 33.54 | 9.59 | 25 | 255840 | 639 | 63232518 |
Cough | 33.25 | 9.59 | 1470 | 254395 | 291273 | 62941884 |
Product quality issue | 33.20 | 9.59 | 253 | 255612 | 35612 | 63197545 |
Nasopharyngitis | 33.09 | 9.59 | 776 | 255089 | 253481 | 62979676 |
Angina pectoris | 32.97 | 9.59 | 221 | 255644 | 29857 | 63203300 |
Foetal methotrexate syndrome | 32.84 | 9.59 | 14 | 255851 | 113 | 63233044 |
Alanine aminotransferase increased | 32.80 | 9.59 | 264 | 255601 | 103506 | 63129651 |
Cardiomyopathy | 32.61 | 9.59 | 149 | 255716 | 17435 | 63215722 |
Erythema | 32.53 | 9.59 | 505 | 255360 | 175246 | 63057911 |
Caesarean section | 32.39 | 9.59 | 14 | 255851 | 17018 | 63216139 |
Panniculitis | 32.13 | 9.59 | 4 | 255861 | 11381 | 63221776 |
Rheumatic fever | 31.83 | 9.59 | 289 | 255576 | 42822 | 63190335 |
Decreased appetite | 31.52 | 9.59 | 1274 | 254591 | 249778 | 62983379 |
Status epilepticus | 31.48 | 9.59 | 11 | 255854 | 15222 | 63217935 |
BRASH syndrome | 31.46 | 9.59 | 21 | 255844 | 448 | 63232709 |
Therapeutic product effect decreased | 31.23 | 9.59 | 569 | 255296 | 192618 | 63040539 |
Sleep disorder due to general medical condition, insomnia type | 31.09 | 9.59 | 107 | 255758 | 52110 | 63181047 |
Pulseless electrical activity | 30.93 | 9.59 | 83 | 255782 | 7438 | 63225719 |
International normalised ratio increased | 30.69 | 9.59 | 304 | 255561 | 46121 | 63187036 |
Psoriatic arthropathy | 30.67 | 9.59 | 529 | 255336 | 90991 | 63142166 |
Hyperlipidaemia | 30.66 | 9.59 | 158 | 255707 | 19413 | 63213744 |
Foetal death | 30.64 | 9.59 | 4 | 255861 | 10976 | 63222181 |
Hypoaldosteronism | 30.62 | 9.59 | 15 | 255850 | 172 | 63232985 |
Abdominal discomfort | 30.57 | 9.59 | 1023 | 254842 | 319862 | 62913295 |
Amnesia | 29.78 | 9.59 | 349 | 255516 | 55236 | 63177921 |
Gastrointestinal disorder | 29.70 | 9.59 | 362 | 255503 | 130877 | 63102280 |
Body temperature decreased | 29.69 | 9.59 | 23 | 255842 | 20296 | 63212861 |
Device expulsion | 29.60 | 9.59 | 60 | 255805 | 34862 | 63198295 |
Depression | 29.44 | 9.59 | 1017 | 254848 | 195475 | 63037682 |
Neutrophil count decreased | 29.42 | 9.59 | 122 | 255743 | 56284 | 63176873 |
Myocardial ischaemia | 29.30 | 9.59 | 116 | 255749 | 12743 | 63220414 |
Anti-cyclic citrullinated peptide antibody | 29.23 | 9.59 | 76 | 255789 | 6682 | 63226475 |
Hepatitis | 29.14 | 9.59 | 74 | 255791 | 39714 | 63193443 |
Tongue oedema | 29.14 | 9.59 | 60 | 255805 | 4526 | 63228631 |
Pregnancy | 28.97 | 9.59 | 66 | 255799 | 36770 | 63196387 |
Rotator cuff repair | 28.56 | 9.59 | 39 | 255826 | 2095 | 63231062 |
Encephalomalacia | 28.17 | 9.59 | 20 | 255845 | 473 | 63232684 |
Blood loss anaemia | 28.06 | 9.59 | 90 | 255775 | 8911 | 63224246 |
Blood glucose decreased | 28.01 | 9.59 | 162 | 255703 | 20790 | 63212367 |
Adverse drug reaction | 27.89 | 9.59 | 464 | 255401 | 79250 | 63153907 |
Lymphopenia | 27.74 | 9.59 | 20 | 255845 | 18307 | 63214850 |
Colitis ulcerative | 27.48 | 9.59 | 39 | 255826 | 26052 | 63207105 |
Therapy partial responder | 27.20 | 9.59 | 5 | 255860 | 10653 | 63222504 |
Toxic skin eruption | 27.16 | 9.59 | 9 | 255856 | 12876 | 63220281 |
Wound infection | 26.98 | 9.59 | 163 | 255702 | 21247 | 63211910 |
Red blood cell sedimentation rate increased | 26.95 | 9.59 | 89 | 255776 | 43893 | 63189264 |
Atrioventricular block first degree | 26.69 | 9.59 | 77 | 255788 | 7196 | 63225961 |
Bronchiectasis | 26.62 | 9.59 | 16 | 255849 | 16126 | 63217031 |
Fall | 26.45 | 9.59 | 1878 | 253987 | 390456 | 62842701 |
Progressive multifocal leukoencephalopathy | 25.74 | 9.59 | 10 | 255855 | 12961 | 63220196 |
Wound | 25.71 | 9.59 | 483 | 255382 | 162780 | 63070377 |
Coronary artery occlusion | 25.63 | 9.59 | 82 | 255783 | 8109 | 63225048 |
Blood pressure systolic increased | 25.04 | 9.59 | 102 | 255763 | 47295 | 63185862 |
Sight disability | 25.01 | 9.59 | 12 | 255853 | 131 | 63233026 |
Abnormal dreams | 24.88 | 9.59 | 96 | 255769 | 10420 | 63222737 |
Pancytopenia | 24.83 | 9.59 | 260 | 255605 | 96673 | 63136484 |
Blood potassium increased | 24.76 | 9.59 | 142 | 255723 | 18167 | 63214990 |
Colitis ischaemic | 24.72 | 9.59 | 97 | 255768 | 10611 | 63222546 |
Factor VII deficiency | 24.67 | 9.59 | 8 | 255857 | 26 | 63233131 |
Oedema peripheral | 24.53 | 9.59 | 965 | 254900 | 188546 | 63044611 |
Vision blurred | 24.50 | 9.59 | 513 | 255352 | 91411 | 63141746 |
Joint range of motion decreased | 24.25 | 9.59 | 218 | 255647 | 32210 | 63200947 |
Stomatitis | 24.20 | 9.59 | 403 | 255462 | 138322 | 63094835 |
Septic shock | 24.18 | 9.59 | 163 | 255702 | 66466 | 63166691 |
Abdominal pain upper | 24.16 | 9.59 | 1040 | 254825 | 205404 | 63027753 |
Dysphagia | 24.14 | 9.59 | 496 | 255369 | 88089 | 63145068 |
Blood parathyroid hormone decreased | 24.13 | 9.59 | 5 | 255860 | 9786 | 63223371 |
Hepatorenal syndrome | 23.90 | 9.59 | 34 | 255831 | 1898 | 63231259 |
Walking aid user | 23.87 | 9.59 | 96 | 255769 | 10621 | 63222536 |
Cytokine release syndrome | 23.87 | 9.59 | 14 | 255851 | 14300 | 63218857 |
Synostosis | 23.65 | 9.59 | 9 | 255856 | 52 | 63233105 |
Gamma-glutamyltransferase increased | 23.62 | 9.59 | 65 | 255800 | 33966 | 63199191 |
Epilepsy | 23.37 | 9.59 | 46 | 255819 | 27019 | 63206138 |
Vomiting | 23.22 | 9.59 | 2585 | 253280 | 557032 | 62676125 |
Sleep disorder due to a general medical condition | 23.21 | 9.59 | 10 | 255855 | 12178 | 63220979 |
Allergic cough | 23.12 | 9.59 | 21 | 255844 | 713 | 63232444 |
Diabetic neuropathy | 23.03 | 9.59 | 50 | 255815 | 3914 | 63229243 |
Drug dispensed to wrong patient | 23.01 | 9.59 | 15 | 255850 | 307 | 63232850 |
Eosinophilia | 23 | 9.59 | 35 | 255830 | 22721 | 63210436 |
Thrombotic microangiopathy | 22.93 | 9.59 | 7 | 255858 | 10554 | 63222603 |
Therapy cessation | 22.90 | 9.59 | 205 | 255660 | 30252 | 63202905 |
Rash maculo-papular | 22.84 | 9.59 | 60 | 255805 | 31836 | 63201321 |
Thermohypoaesthesia | 22.77 | 9.59 | 11 | 255854 | 122 | 63233035 |
Haematotoxicity | 22.68 | 9.59 | 5 | 255860 | 9371 | 63223786 |
Neurotoxicity | 22.66 | 9.59 | 21 | 255844 | 16969 | 63216188 |
Lymphomatoid papulosis | 22.62 | 9.59 | 11 | 255854 | 124 | 63233033 |
Blood potassium decreased | 22.57 | 9.59 | 264 | 255601 | 41762 | 63191395 |
Muscle relaxant therapy | 22.46 | 9.59 | 12 | 255853 | 167 | 63232990 |
Deep vein thrombosis postoperative | 22.33 | 9.59 | 98 | 255767 | 11271 | 63221886 |
Obesity | 22.22 | 9.59 | 201 | 255664 | 29751 | 63203406 |
Oedema mouth | 22.17 | 9.59 | 37 | 255828 | 2376 | 63230781 |
Cholestasis | 22.13 | 9.59 | 54 | 255811 | 29380 | 63203777 |
Drug eruption | 22.09 | 9.59 | 52 | 255813 | 28642 | 63204515 |
Nodal rhythm | 22.05 | 9.59 | 31 | 255834 | 1712 | 63231445 |
Abortion induced | 21.86 | 9.59 | 7 | 255858 | 10235 | 63222922 |
Bone marrow failure | 21.82 | 9.59 | 54 | 255811 | 29236 | 63203921 |
Diabetic ketoacidosis | 21.48 | 9.59 | 149 | 255716 | 20356 | 63212801 |
Hepatic enzyme increased | 21.43 | 9.59 | 636 | 255229 | 201692 | 63031465 |
Chronic obstructive pulmonary disease | 21.23 | 9.59 | 363 | 255502 | 62323 | 63170834 |
Syncope | 21.08 | 9.59 | 621 | 255244 | 116764 | 63116393 |
Nodular rash | 20.94 | 9.59 | 12 | 255853 | 193 | 63232964 |
Hepatocellular injury | 20.77 | 9.59 | 50 | 255815 | 27331 | 63205826 |
Breast cancer stage III | 20.76 | 9.59 | 90 | 255775 | 10296 | 63222861 |
Pemphigoid | 20.73 | 9.59 | 71 | 255794 | 7273 | 63225884 |
Gout | 20.69 | 9.59 | 107 | 255758 | 13164 | 63219993 |
Swelling | 20.67 | 9.59 | 903 | 254962 | 274475 | 62958682 |
Ill-defined disorder | 20.65 | 9.59 | 220 | 255645 | 81535 | 63151622 |
Dysgeusia | 20.64 | 9.59 | 283 | 255582 | 46427 | 63186730 |
Lupus vulgaris | 20.60 | 9.59 | 62 | 255803 | 5932 | 63227225 |
Rash | 20.51 | 9.59 | 1964 | 253901 | 558907 | 62674250 |
Pneumonitis | 20.41 | 9.59 | 73 | 255792 | 35149 | 63198008 |
Anhedonia | 20.36 | 9.59 | 93 | 255772 | 10881 | 63222276 |
Lichen planus | 20.35 | 9.59 | 35 | 255830 | 2303 | 63230854 |
Shock | 20.33 | 9.59 | 163 | 255702 | 23300 | 63209857 |
Dilatation atrial | 20.29 | 9.59 | 32 | 255833 | 1959 | 63231198 |
Anxiety | 20.17 | 9.59 | 1071 | 254794 | 216470 | 63016687 |
Poisoning deliberate | 20.13 | 9.59 | 10 | 255855 | 11208 | 63221949 |
Aphthous ulcer | 20.08 | 9.59 | 16 | 255849 | 13922 | 63219235 |
Full blood count decreased | 20 | 9.59 | 176 | 255689 | 25848 | 63207309 |
Neutropenic sepsis | 20.00 | 9.59 | 22 | 255843 | 16416 | 63216741 |
Sinus arrhythmia | 19.84 | 9.59 | 27 | 255838 | 1446 | 63231711 |
Skin exfoliation | 19.81 | 9.59 | 263 | 255602 | 42839 | 63190318 |
Haemophagocytic lymphohistiocytosis | 19.79 | 9.59 | 9 | 255856 | 10618 | 63222539 |
Immunodeficiency | 19.67 | 9.59 | 32 | 255833 | 20222 | 63212935 |
Pharyngeal oedema | 19.60 | 9.59 | 108 | 255757 | 13613 | 63219544 |
Muscle rigidity | 19.53 | 9.59 | 11 | 255854 | 11489 | 63221668 |
Pneumonia | 19.40 | 9.59 | 1581 | 254284 | 455186 | 62777971 |
Electrocardiogram T wave abnormal | 19.20 | 9.59 | 35 | 255830 | 2412 | 63230745 |
Body height decreased | 19.14 | 9.59 | 86 | 255779 | 9992 | 63223165 |
Cognitive disorder | 19.05 | 9.59 | 139 | 255726 | 55676 | 63177481 |
Low birth weight baby | 18.95 | 9.59 | 3 | 255862 | 7126 | 63226031 |
Creatinine renal clearance decreased | 18.58 | 9.59 | 23 | 255842 | 16285 | 63216872 |
Dystonia | 18.52 | 9.59 | 17 | 255848 | 13802 | 63219355 |
Hyponatraemia | 18.49 | 9.59 | 586 | 255279 | 111314 | 63121843 |
Polyneuropathy | 18.34 | 9.59 | 19 | 255846 | 14570 | 63218587 |
Product coating issue | 18.31 | 9.59 | 8 | 255857 | 69 | 63233088 |
Essential hypertension | 18.19 | 9.59 | 53 | 255812 | 4980 | 63228177 |
Gait inability | 18.05 | 9.59 | 307 | 255558 | 52652 | 63180505 |
Ventricular fibrillation | 18.03 | 9.59 | 95 | 255770 | 11772 | 63221385 |
Adactyly | 17.90 | 9.59 | 7 | 255858 | 44 | 63233113 |
Food allergy | 17.84 | 9.59 | 12 | 255853 | 11389 | 63221768 |
Product substitution issue | 17.81 | 9.59 | 118 | 255747 | 15878 | 63217279 |
Poor venous access | 17.75 | 9.59 | 20 | 255845 | 14765 | 63218392 |
Pulmonary toxicity | 17.62 | 9.59 | 8 | 255857 | 9447 | 63223710 |
Blood urea increased | 17.56 | 9.59 | 173 | 255692 | 26206 | 63206951 |
Transcription medication error | 17.50 | 9.59 | 11 | 255854 | 211 | 63232946 |
Swollen joint count increased | 17.41 | 9.59 | 222 | 255643 | 35832 | 63197325 |
Fear | 17.37 | 9.59 | 116 | 255749 | 15650 | 63217507 |
Deformity | 17.36 | 9.59 | 13 | 255852 | 11671 | 63221486 |
Uveitis | 17.36 | 9.59 | 15 | 255850 | 12538 | 63220619 |
Lymphocyte count decreased | 17.34 | 9.59 | 63 | 255802 | 30194 | 63202963 |
Adverse event | 17.34 | 9.59 | 375 | 255490 | 67184 | 63165973 |
Tuberculosis | 17.27 | 9.59 | 12 | 255853 | 11199 | 63221958 |
Productive cough | 17.24 | 9.59 | 167 | 255698 | 63041 | 63170116 |
Premature labour | 17.22 | 9.59 | 15 | 255850 | 12489 | 63220668 |
Infective pulmonary exacerbation of cystic fibrosis | 17.16 | 9.59 | 7 | 255858 | 8810 | 63224347 |
Charles Bonnet syndrome | 17.14 | 9.59 | 5 | 255860 | 10 | 63233147 |
Extrapyramidal disorder | 17.04 | 9.59 | 17 | 255848 | 13267 | 63219890 |
Gait disturbance | 17.01 | 9.59 | 902 | 254963 | 182276 | 63050881 |
Wheezing | 16.96 | 9.59 | 505 | 255360 | 95090 | 63138067 |
Upper gastrointestinal haemorrhage | 16.90 | 9.59 | 132 | 255733 | 18720 | 63214437 |
Fluid intake reduced | 16.84 | 9.59 | 42 | 255823 | 3599 | 63229558 |
Blood pressure diastolic decreased | 16.80 | 9.59 | 42 | 255823 | 22664 | 63210493 |
Peripheral vascular disorder | 16.73 | 9.59 | 58 | 255807 | 5977 | 63227180 |
Hypophagia | 16.62 | 9.59 | 196 | 255669 | 31063 | 63202094 |
Pre-eclampsia | 16.60 | 9.59 | 8 | 255857 | 9125 | 63224032 |
Hypergammaglobulinaemia | 16.59 | 9.59 | 15 | 255850 | 506 | 63232651 |
Metastases to liver | 16.52 | 9.59 | 45 | 255820 | 23594 | 63209563 |
Epstein-Barr virus infection | 16.32 | 9.59 | 6 | 255859 | 8044 | 63225113 |
Weight decreased | 16.28 | 9.59 | 1311 | 254554 | 275487 | 62957670 |
Ventricular hypertrophy | 16.28 | 9.59 | 40 | 255825 | 3396 | 63229761 |
Oral candidiasis | 16.23 | 9.59 | 43 | 255822 | 22755 | 63210402 |
Suspected suicide attempt | 16.14 | 9.59 | 9 | 255856 | 137 | 63233020 |
Muscular weakness | 16.05 | 9.59 | 624 | 255241 | 121729 | 63111428 |
Transplant rejection | 16.01 | 9.59 | 12 | 255853 | 10768 | 63222389 |
Neuroleptic malignant syndrome | 15.96 | 9.59 | 15 | 255850 | 12041 | 63221116 |
Feeling abnormal | 15.91 | 9.59 | 741 | 255124 | 147651 | 63085506 |
Device difficult to use | 15.71 | 9.59 | 17 | 255848 | 12779 | 63220378 |
Blood pressure abnormal | 15.66 | 9.59 | 110 | 255755 | 15088 | 63218069 |
Jaundice cholestatic | 15.64 | 9.59 | 5 | 255860 | 7319 | 63225838 |
Cerebral thrombosis | 15.63 | 9.59 | 26 | 255839 | 1665 | 63231492 |
Graft versus host disease | 15.58 | 9.59 | 4 | 255861 | 6759 | 63226398 |
Nephrogenic systemic fibrosis | 15.54 | 9.59 | 47 | 255818 | 4509 | 63228648 |
Blood lactate dehydrogenase increased | 15.42 | 9.59 | 45 | 255820 | 23071 | 63210086 |
Oropharyngeal pain | 15.34 | 9.59 | 278 | 255587 | 94209 | 63138948 |
Hereditary angioedema with normal C1 esterase inhibitor | 15.32 | 9.59 | 4 | 255861 | 4 | 63233153 |
Gastrointestinal toxicity | 15.31 | 9.59 | 6 | 255859 | 7735 | 63225422 |
Condition aggravated | 15.16 | 9.59 | 1405 | 254460 | 400812 | 62832345 |
Infusion site pain | 15.15 | 9.59 | 28 | 255837 | 16841 | 63216316 |
Expired product administered | 15.10 | 9.59 | 57 | 255808 | 6124 | 63227033 |
Eosinophilic oesophagitis | 15.07 | 9.59 | 12 | 255853 | 339 | 63232818 |
Electrocardiogram T wave peaked | 14.99 | 9.59 | 10 | 255855 | 213 | 63232944 |
Respiratory depression | 14.94 | 9.59 | 20 | 255845 | 13695 | 63219462 |
Factor VIII inhibition | 14.92 | 9.59 | 6 | 255859 | 41 | 63233116 |
Multimorbidity | 14.92 | 9.59 | 15 | 255850 | 579 | 63232578 |
Schizophrenia | 14.88 | 9.59 | 11 | 255854 | 9941 | 63223216 |
Shock haemorrhagic | 14.71 | 9.59 | 11 | 255854 | 9884 | 63223273 |
Torsade de pointes | 14.57 | 9.59 | 98 | 255767 | 13253 | 63219904 |
Haemodialysis | 14.55 | 9.59 | 73 | 255792 | 8874 | 63224283 |
Mydriasis | 14.55 | 9.59 | 16 | 255849 | 11940 | 63221217 |
Disease progression | 14.50 | 9.59 | 380 | 255485 | 122378 | 63110779 |
Oral herpes | 14.48 | 9.59 | 55 | 255810 | 26019 | 63207138 |
Visual acuity reduced | 14.46 | 9.59 | 143 | 255722 | 21683 | 63211474 |
Urethral prolapse | 14.43 | 9.59 | 4 | 255861 | 6 | 63233151 |
Application site nodule | 14.43 | 9.59 | 4 | 255861 | 6 | 63233151 |
Acne | 14.36 | 9.59 | 47 | 255818 | 23246 | 63209911 |
Inflammation | 14.34 | 9.59 | 239 | 255626 | 82034 | 63151123 |
Blood creatinine increased | 14.24 | 9.59 | 459 | 255406 | 87385 | 63145772 |
Transient psychosis | 14.23 | 9.59 | 6 | 255859 | 47 | 63233110 |
Nervousness | 14.23 | 9.59 | 189 | 255676 | 30790 | 63202367 |
Accelerated hypertension | 14.20 | 9.59 | 13 | 255852 | 446 | 63232711 |
Unresponsive to stimuli | 14.18 | 9.59 | 203 | 255662 | 33613 | 63199544 |
Immune thrombocytopenia | 14.13 | 9.59 | 13 | 255852 | 10543 | 63222614 |
Delirium | 14.10 | 9.59 | 284 | 255581 | 50257 | 63182900 |
Dizziness postural | 14.05 | 9.59 | 63 | 255802 | 7313 | 63225844 |
Glomerulonephropathy | 14.01 | 9.59 | 7 | 255858 | 84 | 63233073 |
Therapeutic response unexpected | 13.97 | 9.59 | 126 | 255739 | 18633 | 63214524 |
Drug clearance decreased | 13.96 | 9.59 | 23 | 255842 | 1461 | 63231696 |
Ankylosing spondylitis | 13.90 | 9.59 | 13 | 255852 | 10461 | 63222696 |
Mouth ulceration | 13.89 | 9.59 | 77 | 255788 | 32907 | 63200250 |
Non-cardiac chest pain | 13.83 | 9.59 | 56 | 255809 | 6216 | 63226941 |
Device dislocation | 13.78 | 9.59 | 55 | 255810 | 25650 | 63207507 |
Chronic sinusitis | 13.72 | 9.59 | 19 | 255846 | 12824 | 63220333 |
Paramnesia | 13.71 | 9.59 | 4 | 255861 | 8 | 63233149 |
Stridor | 13.70 | 9.59 | 38 | 255827 | 3472 | 63229685 |
Facial nerve disorder | 13.62 | 9.59 | 14 | 255851 | 555 | 63232602 |
Diffuse large B-cell lymphoma | 13.61 | 9.59 | 5 | 255860 | 6707 | 63226450 |
Pharyngitis | 13.59 | 9.59 | 39 | 255826 | 20104 | 63213053 |
Conjunctivitis | 13.50 | 9.59 | 41 | 255824 | 20755 | 63212402 |
Bezoar | 13.49 | 9.59 | 23 | 255842 | 1503 | 63231654 |
Cerebral atrophy | 13.45 | 9.59 | 48 | 255817 | 5018 | 63228139 |
Muscle injury | 13.39 | 9.59 | 184 | 255681 | 65161 | 63167996 |
Withdrawal hypertension | 13.37 | 9.59 | 8 | 255857 | 140 | 63233017 |
Rheumatoid arthritis | 13.26 | 9.59 | 863 | 255002 | 252956 | 62980201 |
Sciatica | 13.20 | 9.59 | 203 | 255662 | 34121 | 63199036 |
Female genital tract fistula | 13.17 | 9.59 | 7 | 255858 | 7552 | 63225605 |
Macular degeneration | 13.16 | 9.59 | 52 | 255813 | 24324 | 63208833 |
Exercise tolerance increased | 12.98 | 9.59 | 5 | 255860 | 30 | 63233127 |
Left ventricular hypertrophy | 12.97 | 9.59 | 49 | 255816 | 5266 | 63227891 |
Gastric ulcer helicobacter | 12.83 | 9.59 | 4 | 255861 | 11 | 63233146 |
Impaired healing | 12.75 | 9.59 | 315 | 255550 | 102227 | 63130930 |
Demyelination | 12.67 | 9.59 | 6 | 255859 | 6914 | 63226243 |
Tachycardia | 12.60 | 9.59 | 371 | 255494 | 117785 | 63115372 |
Osmolar gap increased | 12.58 | 9.59 | 7 | 255858 | 106 | 63233051 |
Apparent death | 12.47 | 9.59 | 20 | 255845 | 1242 | 63231915 |
Acute myeloid leukaemia | 12.47 | 9.59 | 32 | 255833 | 17115 | 63216042 |
Chromatopsia | 12.47 | 9.59 | 12 | 255853 | 439 | 63232718 |
Concomitant disease aggravated | 12.46 | 9.59 | 11 | 255854 | 9101 | 63224056 |
Laryngotracheal oedema | 12.33 | 9.59 | 5 | 255860 | 35 | 63233122 |
Lacunar infarction | 12.30 | 9.59 | 35 | 255830 | 3245 | 63229912 |
Peripheral swelling | 12.28 | 9.59 | 914 | 254951 | 265028 | 62968129 |
Sinus disorder | 12.20 | 9.59 | 152 | 255713 | 24401 | 63208756 |
Blood electrolytes abnormal | 12.15 | 9.59 | 18 | 255847 | 1043 | 63232114 |
Blood calcium decreased | 12.12 | 9.59 | 60 | 255805 | 26391 | 63206766 |
Carotid artery stenosis | 12.07 | 9.59 | 47 | 255818 | 5123 | 63228034 |
Craniosynostosis | 12.05 | 9.59 | 8 | 255857 | 169 | 63232988 |
Lip oedema | 12.02 | 9.59 | 39 | 255826 | 3885 | 63229272 |
Cholelithiasis | 11.98 | 9.59 | 246 | 255619 | 43679 | 63189478 |
Fear of eating | 11.93 | 9.59 | 11 | 255854 | 381 | 63232776 |
Hypogammaglobulinaemia | 11.93 | 9.59 | 7 | 255858 | 7148 | 63226009 |
Diverticulum | 11.90 | 9.59 | 86 | 255779 | 11905 | 63221252 |
Sinusitis | 11.77 | 9.59 | 771 | 255094 | 225882 | 63007275 |
Temperature regulation disorder | 11.72 | 9.59 | 5 | 255860 | 6127 | 63227030 |
Occult blood positive | 11.72 | 9.59 | 37 | 255828 | 3633 | 63229524 |
Catheterisation cardiac | 11.70 | 9.59 | 43 | 255822 | 4560 | 63228597 |
Erythema marginatum | 11.70 | 9.59 | 4 | 255861 | 16 | 63233141 |
Hypertensive urgency | 11.58 | 9.59 | 10 | 255855 | 317 | 63232840 |
Dysarthria | 11.58 | 9.59 | 239 | 255626 | 42472 | 63190685 |
Hypertrophic cardiomyopathy | 11.58 | 9.59 | 22 | 255843 | 1565 | 63231592 |
Emotional distress | 11.58 | 9.59 | 190 | 255675 | 32359 | 63200798 |
Raynaud's phenomenon | 11.56 | 9.59 | 19 | 255846 | 1205 | 63231952 |
Hypertensive crisis | 11.55 | 9.59 | 103 | 255762 | 15183 | 63217974 |
Generalised tonic-clonic seizure | 11.54 | 9.59 | 69 | 255796 | 28947 | 63204210 |
Liver function test increased | 11.54 | 9.59 | 81 | 255784 | 32730 | 63200427 |
Blood pressure diastolic increased | 11.53 | 9.59 | 14 | 255851 | 9996 | 63223161 |
Back disorder | 11.51 | 9.59 | 80 | 255785 | 10937 | 63222220 |
Ischaemic neuropathy | 11.49 | 9.59 | 3 | 255862 | 3 | 63233154 |
Hyperthermia | 11.42 | 9.59 | 12 | 255853 | 9144 | 63224013 |
Premature rupture of membranes | 11.41 | 9.59 | 3 | 255862 | 4990 | 63228167 |
Forced expiratory volume decreased | 11.33 | 9.59 | 3 | 255862 | 4965 | 63228192 |
Burn oesophageal | 11.28 | 9.59 | 8 | 255857 | 189 | 63232968 |
Pericarditis | 11.24 | 9.59 | 425 | 255440 | 131154 | 63102003 |
Retching | 11.23 | 9.59 | 99 | 255766 | 14546 | 63218611 |
Myalgia | 11.19 | 9.59 | 709 | 255156 | 145820 | 63087337 |
Herpes zoster | 11.18 | 9.59 | 250 | 255615 | 82212 | 63150945 |
Treatment noncompliance | 11.18 | 9.59 | 212 | 255653 | 37113 | 63196044 |
General physical health deterioration | 11.17 | 9.59 | 681 | 255184 | 200721 | 63032436 |
Eosinophilic pneumonia acute | 11.15 | 9.59 | 11 | 255854 | 415 | 63232742 |
Autoimmune disorder | 11.12 | 9.59 | 112 | 255753 | 17065 | 63216092 |
C-reactive protein | 11.09 | 9.59 | 44 | 255821 | 4838 | 63228319 |
Fracture | 11.08 | 9.59 | 41 | 255824 | 19543 | 63213614 |
Aspartate aminotransferase increased | 11.04 | 9.59 | 278 | 255587 | 89999 | 63143158 |
Rhinitis | 11.00 | 9.59 | 18 | 255847 | 11348 | 63221809 |
Weight increased | 10.99 | 9.59 | 903 | 254962 | 259889 | 62973268 |
Uraemic encephalopathy | 10.90 | 9.59 | 9 | 255856 | 268 | 63232889 |
Venoocclusive liver disease | 10.87 | 9.59 | 3 | 255862 | 4832 | 63228325 |
Hyperbilirubinaemia | 10.87 | 9.59 | 18 | 255847 | 11296 | 63221861 |
Cardioactive drug level increased | 10.84 | 9.59 | 26 | 255839 | 2174 | 63230983 |
Retroperitoneal oedema | 10.83 | 9.59 | 4 | 255861 | 21 | 63233136 |
Joint effusion | 10.81 | 9.59 | 34 | 255831 | 17026 | 63216131 |
Laboratory test abnormal | 10.67 | 9.59 | 160 | 255705 | 26752 | 63206405 |
Ovarian cyst | 10.66 | 9.59 | 31 | 255834 | 15914 | 63217243 |
SUNCT syndrome | 10.63 | 9.59 | 3 | 255862 | 5 | 63233152 |
Fear of injection | 10.61 | 9.59 | 8 | 255857 | 7156 | 63226001 |
Product solubility abnormal | 10.58 | 9.59 | 15 | 255850 | 835 | 63232322 |
Coronary artery surgery | 10.55 | 9.59 | 5 | 255860 | 53 | 63233104 |
Osteoporosis | 10.51 | 9.59 | 165 | 255700 | 57173 | 63175984 |
Refusal of treatment by patient | 10.51 | 9.59 | 47 | 255818 | 5450 | 63227707 |
Hereditary angioedema | 10.50 | 9.59 | 9 | 255856 | 7553 | 63225604 |
Foetal growth restriction | 10.47 | 9.59 | 9 | 255856 | 7544 | 63225613 |
Tonsillitis | 10.46 | 9.59 | 5 | 255860 | 5730 | 63227427 |
Folliculitis | 10.46 | 9.59 | 210 | 255655 | 70107 | 63163050 |
Bradycardia | 10.45 | 9.59 | 377 | 255488 | 72850 | 63160307 |
Second primary malignancy | 10.41 | 9.59 | 10 | 255855 | 7943 | 63225214 |
Visceral oedema | 10.39 | 9.59 | 4 | 255861 | 24 | 63233133 |
Bundle branch block left | 10.38 | 9.59 | 56 | 255809 | 7003 | 63226154 |
Asphyxia | 10.37 | 9.59 | 6 | 255859 | 6175 | 63226982 |
Acute generalised exanthematous pustulosis | 10.35 | 9.59 | 18 | 255847 | 11081 | 63222076 |
Normal newborn | 10.33 | 9.59 | 11 | 255854 | 8330 | 63224827 |
Foreign body in reproductive tract | 10.33 | 9.59 | 14 | 255851 | 747 | 63232410 |
Autonomic failure syndrome | 10.28 | 9.59 | 3 | 255862 | 6 | 63233151 |
Gallbladder abscess | 10.28 | 9.59 | 3 | 255862 | 6 | 63233151 |
Purpura senile | 10.26 | 9.59 | 12 | 255853 | 551 | 63232606 |
Optic ischaemic neuropathy | 10.26 | 9.59 | 18 | 255847 | 1204 | 63231953 |
Intestinal ischaemia | 10.15 | 9.59 | 58 | 255807 | 7410 | 63225747 |
Choroidal effusion | 10.13 | 9.59 | 11 | 255854 | 465 | 63232692 |
Diabetic gastroparesis | 10.12 | 9.59 | 9 | 255856 | 297 | 63232860 |
Electrocardiogram ST segment depression | 10.12 | 9.59 | 30 | 255835 | 2847 | 63230310 |
Hypertensive emergency | 10.10 | 9.59 | 23 | 255842 | 1859 | 63231298 |
Hypoglycaemic unconsciousness | 10.10 | 9.59 | 14 | 255851 | 763 | 63232394 |
Macular fibrosis | 10.08 | 9.59 | 10 | 255855 | 380 | 63232777 |
Neoplasm progression | 10.03 | 9.59 | 96 | 255769 | 36332 | 63196825 |
Multiple fractures | 9.98 | 9.59 | 12 | 255853 | 8606 | 63224551 |
Haemorrhage intracranial | 9.92 | 9.59 | 90 | 255775 | 13329 | 63219828 |
Adrenal insufficiency | 9.81 | 9.59 | 38 | 255827 | 17877 | 63215280 |
Eye swelling | 9.80 | 9.59 | 143 | 255722 | 23775 | 63209382 |
Alanine aminotransferase abnormal | 9.75 | 9.59 | 3 | 255862 | 4501 | 63228656 |
Neutrophil count increased | 9.75 | 9.59 | 34 | 255831 | 16493 | 63216664 |
Tubulointerstitial nephritis and uveitis syndrome | 9.73 | 9.59 | 8 | 255857 | 237 | 63232920 |
Urinary tract candidiasis | 9.72 | 9.59 | 12 | 255853 | 583 | 63232574 |
Electrocardiogram QT prolonged | 9.71 | 9.59 | 175 | 255690 | 59355 | 63173802 |
Pathogen resistance | 9.66 | 9.59 | 7 | 255858 | 6391 | 63226766 |
Drug use disorder | 9.63 | 9.59 | 4 | 255861 | 4980 | 63228177 |
Discomfort | 9.62 | 9.59 | 564 | 255301 | 166810 | 63066347 |
Glomerulonephritis | 9.61 | 9.59 | 22 | 255843 | 1784 | 63231373 |
Ageusia | 9.61 | 9.59 | 91 | 255774 | 13637 | 63219520 |
Mitral valve incompetence | 9.61 | 9.59 | 121 | 255744 | 19473 | 63213684 |
Restrictive cardiomyopathy | 9.61 | 9.59 | 9 | 255856 | 318 | 63232839 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Angioedema | 11128.91 | 10.93 | 5073 | 200499 | 32301 | 34719058 |
Myocardial infarction | 649.90 | 10.93 | 1869 | 203703 | 119216 | 34632143 |
Cardiac failure congestive | 645.68 | 10.93 | 1477 | 204095 | 81793 | 34669566 |
Hyperkalaemia | 597.82 | 10.93 | 1284 | 204288 | 68105 | 34683254 |
Swollen tongue | 530.01 | 10.93 | 535 | 205037 | 14070 | 34737289 |
Lip swelling | 483.73 | 10.93 | 533 | 205039 | 15547 | 34735812 |
Off label use | 477.51 | 10.93 | 1107 | 204465 | 418417 | 34332942 |
Completed suicide | 380.72 | 10.93 | 1356 | 204216 | 96812 | 34654547 |
Coronary artery disease | 365.37 | 10.93 | 849 | 204723 | 47456 | 34703903 |
Acute kidney injury | 341.42 | 10.93 | 3002 | 202570 | 301986 | 34449373 |
Drug abuse | 298.36 | 10.93 | 105 | 205467 | 98991 | 34652368 |
Febrile neutropenia | 291.29 | 10.93 | 227 | 205345 | 136622 | 34614737 |
Cerebrovascular accident | 284.94 | 10.93 | 1119 | 204453 | 83692 | 34667667 |
Swelling face | 239.55 | 10.93 | 462 | 205110 | 22643 | 34728716 |
Pyrexia | 233.91 | 10.93 | 1086 | 204486 | 331927 | 34419432 |
General physical health deterioration | 232.19 | 10.93 | 247 | 205325 | 128022 | 34623337 |
Hypotension | 215.76 | 10.93 | 2119 | 203453 | 219530 | 34531829 |
Neutropenia | 204.10 | 10.93 | 382 | 205190 | 156396 | 34594963 |
Acute myocardial infarction | 182.88 | 10.93 | 712 | 204860 | 53007 | 34698352 |
Interstitial lung disease | 165.02 | 10.93 | 89 | 205483 | 65193 | 34686166 |
Dizziness | 152.72 | 10.93 | 1958 | 203614 | 216563 | 34534796 |
Foetal exposure during pregnancy | 135.86 | 10.93 | 29 | 205543 | 38072 | 34713287 |
Drug hypersensitivity | 126.44 | 10.93 | 859 | 204713 | 79670 | 34671689 |
Intestinal angioedema | 125.29 | 10.93 | 48 | 205524 | 179 | 34751180 |
Drug ineffective | 125.24 | 10.93 | 1913 | 203659 | 454838 | 34296521 |
Coronary arterial stent insertion | 122.63 | 10.93 | 136 | 205436 | 3993 | 34747366 |
Hepatic function abnormal | 121.94 | 10.93 | 54 | 205518 | 44309 | 34707050 |
Pancreatitis | 117.63 | 10.93 | 497 | 205075 | 38394 | 34712965 |
Condition aggravated | 106.78 | 10.93 | 677 | 204895 | 191519 | 34559840 |
Psoriasis | 106.71 | 10.93 | 482 | 205090 | 38330 | 34713029 |
Coronary artery bypass | 103.84 | 10.93 | 136 | 205436 | 4766 | 34746593 |
C-reactive protein increased | 103.68 | 10.93 | 99 | 205473 | 53999 | 34697360 |
Thrombocytopenia | 102.63 | 10.93 | 521 | 205051 | 155726 | 34595633 |
Septic shock | 101.54 | 10.93 | 166 | 205406 | 71668 | 34679691 |
Dehydration | 101.16 | 10.93 | 1189 | 204383 | 128780 | 34622579 |
Product use in unapproved indication | 100.50 | 10.93 | 354 | 205218 | 117145 | 34634214 |
Suspected suicide | 96.37 | 10.93 | 129 | 205443 | 4619 | 34746740 |
Pharyngeal oedema | 94.39 | 10.93 | 145 | 205427 | 5902 | 34745457 |
Leukopenia | 93.84 | 10.93 | 140 | 205432 | 62716 | 34688643 |
Anaphylactic reaction | 87.94 | 10.93 | 400 | 205172 | 31901 | 34719458 |
Cholestasis | 87.35 | 10.93 | 25 | 205547 | 26923 | 34724436 |
Drug resistance | 86.01 | 10.93 | 23 | 205549 | 25904 | 34725455 |
Product dose omission issue | 82.70 | 10.93 | 1071 | 204501 | 118640 | 34632719 |
Cytomegalovirus infection | 81.53 | 10.93 | 26 | 205546 | 26109 | 34725250 |
Hypotensive transfusion reaction | 77.63 | 10.93 | 20 | 205552 | 6 | 34751353 |
Blood potassium increased | 77.21 | 10.93 | 243 | 205329 | 16252 | 34735107 |
Myelosuppression | 76.67 | 10.93 | 11 | 205561 | 19254 | 34732105 |
Treatment failure | 75.71 | 10.93 | 98 | 205474 | 46599 | 34704760 |
BRASH syndrome | 74.39 | 10.93 | 44 | 205528 | 502 | 34750857 |
Agranulocytosis | 73.78 | 10.93 | 24 | 205548 | 23797 | 34727562 |
Disseminated intravascular coagulation | 73.04 | 10.93 | 19 | 205553 | 21797 | 34729562 |
Bronchopulmonary aspergillosis | 69.94 | 10.93 | 4 | 205568 | 14655 | 34736704 |
Hepatocellular injury | 69.46 | 10.93 | 22 | 205550 | 22189 | 34729170 |
Intentional product use issue | 68.20 | 10.93 | 157 | 205415 | 59659 | 34691700 |
Altered state of consciousness | 65.90 | 10.93 | 26 | 205546 | 22867 | 34728492 |
Blood glucose increased | 64.20 | 10.93 | 637 | 204935 | 66081 | 34685278 |
Chest pain | 63.16 | 10.93 | 1072 | 204500 | 125690 | 34625669 |
Lactic acidosis | 61.28 | 10.93 | 382 | 205190 | 34390 | 34716969 |
Product use issue | 59.85 | 10.93 | 182 | 205390 | 63034 | 34688325 |
Pancytopenia | 59.77 | 10.93 | 322 | 205250 | 94835 | 34656524 |
Mental status changes | 59.57 | 10.93 | 406 | 205166 | 37677 | 34713682 |
Syncope | 59.31 | 10.93 | 809 | 204763 | 90642 | 34660717 |
Neutrophil count decreased | 59.18 | 10.93 | 133 | 205439 | 50971 | 34700388 |
Hypovolaemia | 58.78 | 10.93 | 152 | 205420 | 9082 | 34742277 |
Synovitis | 58.45 | 10.93 | 7 | 205565 | 14059 | 34737300 |
Blood pressure inadequately controlled | 57.09 | 10.93 | 74 | 205498 | 2566 | 34748793 |
Cough | 56.41 | 10.93 | 1216 | 204356 | 148924 | 34602435 |
Epilepsy | 56.23 | 10.93 | 28 | 205544 | 21467 | 34729892 |
Bone marrow failure | 55.49 | 10.93 | 54 | 205518 | 29199 | 34722160 |
Fatigue | 55.13 | 10.93 | 2685 | 202887 | 367968 | 34383391 |
Sopor | 53.09 | 10.93 | 5 | 205567 | 12131 | 34739228 |
Mucosal inflammation | 52.94 | 10.93 | 91 | 205481 | 38531 | 34712828 |
Sepsis | 52.29 | 10.93 | 678 | 204894 | 165883 | 34585476 |
Renal injury | 51.54 | 10.93 | 164 | 205408 | 11031 | 34740328 |
Device interaction | 49.80 | 10.93 | 35 | 205537 | 547 | 34750812 |
Premature baby | 49.24 | 10.93 | 27 | 205545 | 19606 | 34731753 |
Blood lactate dehydrogenase increased | 48.99 | 10.93 | 38 | 205534 | 22952 | 34728407 |
Renal tubular necrosis | 47.87 | 10.93 | 201 | 205371 | 15479 | 34735880 |
Injury | 47.51 | 10.93 | 244 | 205328 | 20443 | 34730916 |
Oral allergy syndrome | 47.41 | 10.93 | 14 | 205558 | 16 | 34751343 |
Hypertensive emergency | 46.98 | 10.93 | 43 | 205529 | 997 | 34750362 |
Multiple organ dysfunction syndrome | 46.48 | 10.93 | 262 | 205310 | 76304 | 34675055 |
Malignant neoplasm progression | 46.33 | 10.93 | 315 | 205257 | 87731 | 34663628 |
International normalised ratio increased | 46.06 | 10.93 | 453 | 205119 | 46874 | 34704485 |
Dysphagia | 45.96 | 10.93 | 565 | 205007 | 61816 | 34689543 |
Coma | 45.79 | 10.93 | 128 | 205444 | 45550 | 34705809 |
Cardiac disorder | 44.54 | 10.93 | 418 | 205154 | 42708 | 34708651 |
Hepatic cytolysis | 44.20 | 10.93 | 15 | 205557 | 14481 | 34736878 |
Gamma-glutamyltransferase increased | 42.75 | 10.93 | 66 | 205506 | 29165 | 34722194 |
Pneumocystis jirovecii pneumonia | 42.74 | 10.93 | 32 | 205540 | 19678 | 34731681 |
Lymphocyte count decreased | 41.49 | 10.93 | 43 | 205529 | 22579 | 34728780 |
Tongue oedema | 41.45 | 10.93 | 68 | 205504 | 2929 | 34748430 |
Alanine aminotransferase increased | 41.10 | 10.93 | 292 | 205280 | 80523 | 34670836 |
Lymphopenia | 40.20 | 10.93 | 23 | 205549 | 16312 | 34735047 |
Hyperthermia | 39.92 | 10.93 | 7 | 205565 | 10570 | 34740789 |
Pancreatitis acute | 39.91 | 10.93 | 293 | 205279 | 27848 | 34723511 |
Toxic skin eruption | 39.90 | 10.93 | 9 | 205563 | 11376 | 34739983 |
Liver disorder | 38.91 | 10.93 | 85 | 205487 | 32912 | 34718447 |
Aspergillus infection | 38.56 | 10.93 | 12 | 205560 | 12242 | 34739117 |
Pneumonia | 38.54 | 10.93 | 1742 | 203830 | 360885 | 34390474 |
Blood urea increased | 38.51 | 10.93 | 308 | 205264 | 30056 | 34721303 |
Vascular graft | 38.25 | 10.93 | 46 | 205526 | 1476 | 34749883 |
Cytokine release syndrome | 38.12 | 10.93 | 47 | 205525 | 22830 | 34728529 |
Renal failure | 37.96 | 10.93 | 1021 | 204551 | 129536 | 34621823 |
Angina unstable | 37.63 | 10.93 | 152 | 205420 | 11501 | 34739858 |
Hypophagia | 37.50 | 10.93 | 256 | 205316 | 23766 | 34727593 |
Immune reconstitution inflammatory syndrome | 37.29 | 10.93 | 4 | 205568 | 8755 | 34742604 |
Therapeutic product effect incomplete | 36.95 | 10.93 | 162 | 205410 | 50379 | 34700980 |
Electrocardiogram T wave peaked | 36.92 | 10.93 | 30 | 205542 | 589 | 34750770 |
Feeling abnormal | 36.81 | 10.93 | 549 | 205023 | 62686 | 34688673 |
Fear | 36.54 | 10.93 | 140 | 205432 | 10336 | 34741023 |
Drug dependence | 36.07 | 10.93 | 54 | 205518 | 24163 | 34727196 |
Hepatitis | 35.89 | 10.93 | 53 | 205519 | 23851 | 34727508 |
Cardiac failure | 35.85 | 10.93 | 353 | 205219 | 90895 | 34660464 |
Drug reaction with eosinophilia and systemic symptoms | 35.75 | 10.93 | 89 | 205483 | 32923 | 34718436 |
Anhedonia | 35.73 | 10.93 | 112 | 205460 | 7473 | 34743886 |
Lung disorder | 35.69 | 10.93 | 96 | 205476 | 34600 | 34716759 |
Infection | 35.60 | 10.93 | 352 | 205220 | 90563 | 34660796 |
Eosinophilia | 34.83 | 10.93 | 63 | 205509 | 26159 | 34725200 |
Platelet count decreased | 34.76 | 10.93 | 495 | 205077 | 119222 | 34632137 |
Blood creatinine increased | 34.60 | 10.93 | 766 | 204806 | 94210 | 34657149 |
Intentional self-injury | 34.45 | 10.93 | 19 | 205553 | 13752 | 34737607 |
Infusion related reaction | 34.15 | 10.93 | 178 | 205394 | 52879 | 34698480 |
Rheumatoid arthritis | 34.14 | 10.93 | 113 | 205459 | 38125 | 34713234 |
Dysphonia | 34.04 | 10.93 | 245 | 205327 | 23138 | 34728221 |
Drug intolerance | 33.94 | 10.93 | 208 | 205364 | 59362 | 34691997 |
Bronchiectasis | 33.85 | 10.93 | 8 | 205564 | 9793 | 34741566 |
Product quality issue | 33.76 | 10.93 | 193 | 205379 | 16842 | 34734517 |
Aplastic anaemia | 33.42 | 10.93 | 8 | 205564 | 9708 | 34741651 |
Vision blurred | 33.28 | 10.93 | 415 | 205157 | 45548 | 34705811 |
Orbital myositis | 32.96 | 10.93 | 16 | 205556 | 118 | 34751241 |
Muscle spasms | 32.96 | 10.93 | 622 | 204950 | 74379 | 34676980 |
Therapy partial responder | 32.91 | 10.93 | 8 | 205564 | 9608 | 34741751 |
Asthenia | 32.73 | 10.93 | 1759 | 203813 | 243492 | 34507867 |
Low birth weight baby | 32.68 | 10.93 | 4 | 205568 | 7901 | 34743458 |
Bradycardia | 32.64 | 10.93 | 624 | 204948 | 74794 | 34676565 |
Thrombotic microangiopathy | 32.41 | 10.93 | 11 | 205561 | 10619 | 34740740 |
Pelvic mass | 32.33 | 10.93 | 19 | 205553 | 214 | 34751145 |
Pathogen resistance | 32.23 | 10.93 | 8 | 205564 | 9474 | 34741885 |
Pneumonitis | 31.72 | 10.93 | 98 | 205474 | 33780 | 34717579 |
Blood glucose decreased | 31.71 | 10.93 | 158 | 205414 | 13079 | 34738280 |
Ischaemic cardiomyopathy | 31.64 | 10.93 | 96 | 205476 | 6293 | 34745066 |
Drug-induced liver injury | 31.01 | 10.93 | 78 | 205494 | 28754 | 34722605 |
Haemophagocytic lymphohistiocytosis | 30.89 | 10.93 | 19 | 205553 | 12954 | 34738405 |
Venoocclusive liver disease | 30.66 | 10.93 | 5 | 205567 | 7961 | 34743398 |
Myocardial ischaemia | 30.51 | 10.93 | 191 | 205381 | 17217 | 34734142 |
Intentional dose omission | 30.33 | 10.93 | 65 | 205507 | 3435 | 34747924 |
Anaemia | 30.29 | 10.93 | 1095 | 204477 | 232240 | 34519119 |
Emotional distress | 30.28 | 10.93 | 171 | 205401 | 14855 | 34736504 |
Blood urea abnormal | 30.04 | 10.93 | 30 | 205542 | 778 | 34750581 |
Ageusia | 29.81 | 10.93 | 130 | 205442 | 10178 | 34741181 |
Neuroleptic malignant syndrome | 29.72 | 10.93 | 37 | 205535 | 17897 | 34733462 |
Haematotoxicity | 29.69 | 10.93 | 6 | 205566 | 8188 | 34743171 |
Drooling | 29.53 | 10.93 | 63 | 205509 | 3319 | 34748040 |
Exposure during pregnancy | 29.49 | 10.93 | 8 | 205564 | 8926 | 34742433 |
Pharyngeal swelling | 29.35 | 10.93 | 50 | 205522 | 2222 | 34749137 |
Pneumonia aspiration | 29.02 | 10.93 | 137 | 205435 | 41766 | 34709593 |
Graft versus host disease | 28.82 | 10.93 | 13 | 205559 | 10556 | 34740803 |
Hyperbilirubinaemia | 28.71 | 10.93 | 34 | 205538 | 16809 | 34734550 |
Therapy cessation | 28.37 | 10.93 | 184 | 205388 | 16789 | 34734570 |
Pulmonary renal syndrome | 28.26 | 10.93 | 16 | 205556 | 167 | 34751192 |
Mouth swelling | 28.26 | 10.93 | 44 | 205528 | 1812 | 34749547 |
Product substitution issue | 28.20 | 10.93 | 126 | 205446 | 9969 | 34741390 |
Drug interaction | 28.05 | 10.93 | 1066 | 204506 | 224880 | 34526479 |
Allergic cough | 27.98 | 10.93 | 10 | 205562 | 29 | 34751330 |
Toxic epidermal necrolysis | 27.87 | 10.93 | 53 | 205519 | 21593 | 34729766 |
Glycosylated haemoglobin increased | 27.50 | 10.93 | 136 | 205436 | 11224 | 34740135 |
Potassium wasting nephropathy | 27.23 | 10.93 | 13 | 205559 | 92 | 34751267 |
Orthostatic hypotension | 27.15 | 10.93 | 252 | 205320 | 25667 | 34725692 |
Dysgeusia | 26.94 | 10.93 | 256 | 205316 | 26241 | 34725118 |
Mydriasis | 26.86 | 10.93 | 5 | 205567 | 7232 | 34744127 |
Hypoglycaemia | 26.41 | 10.93 | 460 | 205112 | 54180 | 34697179 |
Transaminases increased | 26.26 | 10.93 | 76 | 205496 | 26747 | 34724612 |
Ulnar nerve palsy | 25.85 | 10.93 | 7 | 205565 | 4 | 34751355 |
Labelled drug-drug interaction medication error | 25.63 | 10.93 | 30 | 205542 | 14909 | 34736450 |
Diabetic neuropathy | 25.60 | 10.93 | 68 | 205504 | 4129 | 34747230 |
Aspartate aminotransferase increased | 25.47 | 10.93 | 265 | 205307 | 67518 | 34683841 |
Status epilepticus | 25.45 | 10.93 | 22 | 205550 | 12592 | 34738767 |
Post transplant lymphoproliferative disorder | 25.35 | 10.93 | 4 | 205568 | 6524 | 34744835 |
Lower respiratory tract infection | 25.25 | 10.93 | 98 | 205474 | 31539 | 34719820 |
Appendicitis | 25.12 | 10.93 | 30 | 205542 | 14777 | 34736582 |
Neurotoxicity | 25.07 | 10.93 | 42 | 205530 | 17968 | 34733391 |
Pancreatitis necrotising | 24.81 | 10.93 | 52 | 205520 | 2706 | 34748653 |
Transplant rejection | 24.69 | 10.93 | 15 | 205557 | 10296 | 34741063 |
Hyperlipidaemia | 24.59 | 10.93 | 158 | 205414 | 14371 | 34736988 |
Blood electrolytes abnormal | 23.91 | 10.93 | 29 | 205543 | 939 | 34750420 |
Oxygen saturation decreased | 23.82 | 10.93 | 202 | 205370 | 53616 | 34697743 |
Laryngeal oedema | 23.63 | 10.93 | 59 | 205513 | 3449 | 34747910 |
Product complaint | 23.31 | 10.93 | 82 | 205490 | 5808 | 34745551 |
Enterocolitis | 23.29 | 10.93 | 9 | 205563 | 8017 | 34743342 |
Accelerated hypertension | 23.21 | 10.93 | 16 | 205556 | 242 | 34751117 |
Cystitis haemorrhagic | 23.17 | 10.93 | 3 | 205569 | 5676 | 34745683 |
Substance abuse | 23.13 | 10.93 | 8 | 205564 | 7633 | 34743726 |
Oropharyngeal swelling | 23.12 | 10.93 | 21 | 205551 | 482 | 34750877 |
Anal abscess | 22.92 | 10.93 | 5 | 205567 | 6468 | 34744891 |
Prostate cancer recurrent | 22.86 | 10.93 | 29 | 205543 | 984 | 34750375 |
Unevaluable event | 22.63 | 10.93 | 292 | 205280 | 32298 | 34719061 |
Second primary malignancy | 22.62 | 10.93 | 9 | 205563 | 7877 | 34743482 |
Productive cough | 22.61 | 10.93 | 130 | 205442 | 37683 | 34713676 |
Acute hepatic failure | 22.33 | 10.93 | 30 | 205542 | 14044 | 34737315 |
Hypoaesthesia oral | 22.32 | 10.93 | 65 | 205507 | 4164 | 34747195 |
Blood pressure increased | 22.26 | 10.93 | 677 | 204895 | 87425 | 34663934 |
Coronary artery occlusion | 22.25 | 10.93 | 125 | 205447 | 10837 | 34740522 |
Transient ischaemic attack | 22.04 | 10.93 | 254 | 205318 | 27359 | 34724000 |
Increased tendency to bruise | 22.00 | 10.93 | 63 | 205509 | 3998 | 34747361 |
Myalgia | 21.97 | 10.93 | 649 | 204923 | 83461 | 34667898 |
Similar reaction on previous exposure to drug | 21.91 | 10.93 | 9 | 205563 | 42 | 34751317 |
Seizure | 21.89 | 10.93 | 460 | 205112 | 104397 | 34646962 |
Vitreous floaters | 21.78 | 10.93 | 58 | 205514 | 3527 | 34747832 |
Tumour lysis syndrome | 21.76 | 10.93 | 42 | 205530 | 17017 | 34734342 |
Polyneuropathy | 21.43 | 10.93 | 34 | 205538 | 14862 | 34736497 |
Encephalitis | 21.38 | 10.93 | 8 | 205564 | 7269 | 34744090 |
Pancreatitis haemorrhagic | 21.30 | 10.93 | 17 | 205555 | 325 | 34751034 |
Nausea | 21.28 | 10.93 | 2296 | 203276 | 337612 | 34413747 |
Wheezing | 21.26 | 10.93 | 352 | 205220 | 41050 | 34710309 |
Eosinophil count increased | 21.19 | 10.93 | 12 | 205560 | 8560 | 34742799 |
Depressed level of consciousness | 21.19 | 10.93 | 156 | 205416 | 42685 | 34708674 |
No reaction on previous exposure to drug | 21.16 | 10.93 | 10 | 205562 | 69 | 34751290 |
Hepatotoxicity | 20.94 | 10.93 | 61 | 205511 | 21424 | 34729935 |
Nodular rash | 20.72 | 10.93 | 11 | 205561 | 100 | 34751259 |
Disease progression | 20.60 | 10.93 | 481 | 205091 | 107596 | 34643763 |
Azotaemia | 20.39 | 10.93 | 70 | 205502 | 4897 | 34746462 |
Burning sensation | 20.36 | 10.93 | 181 | 205391 | 18213 | 34733146 |
Epstein-Barr virus infection | 19.85 | 10.93 | 10 | 205562 | 7618 | 34743741 |
Asthma | 19.83 | 10.93 | 158 | 205414 | 42498 | 34708861 |
Tuberculosis | 19.82 | 10.93 | 13 | 205559 | 8564 | 34742795 |
Diarrhoea | 19.67 | 10.93 | 2598 | 202974 | 387314 | 34364045 |
Product coating issue | 19.66 | 10.93 | 7 | 205565 | 20 | 34751339 |
Erythema | 19.56 | 10.93 | 386 | 205186 | 88394 | 34662965 |
Gallbladder oedema | 19.43 | 10.93 | 14 | 205558 | 228 | 34751131 |
Hypoaesthesia | 19.43 | 10.93 | 486 | 205086 | 60958 | 34690401 |
COVID-19 | 19.33 | 10.93 | 330 | 205242 | 77220 | 34674139 |
Posterior reversible encephalopathy syndrome | 19.31 | 10.93 | 18 | 205554 | 9936 | 34741423 |
Cytopenia | 19.31 | 10.93 | 28 | 205544 | 12695 | 34738664 |
Akathisia | 19.13 | 10.93 | 12 | 205560 | 8097 | 34743262 |
Maternal exposure during pregnancy | 19.13 | 10.93 | 3 | 205569 | 4915 | 34746444 |
Acute respiratory distress syndrome | 19.12 | 10.93 | 83 | 205489 | 25886 | 34725473 |
Fall | 19.07 | 10.93 | 1412 | 204160 | 201473 | 34549886 |
Pseudomonas infection | 19.03 | 10.93 | 27 | 205545 | 12355 | 34739004 |
Cytomegalovirus viraemia | 18.95 | 10.93 | 10 | 205562 | 7420 | 34743939 |
Colitis | 18.89 | 10.93 | 137 | 205435 | 37613 | 34713746 |
Miosis | 18.79 | 10.93 | 17 | 205555 | 9518 | 34741841 |
Atrial fibrillation | 18.78 | 10.93 | 890 | 204682 | 121503 | 34629856 |
Progressive multifocal leukoencephalopathy | 18.54 | 10.93 | 18 | 205554 | 9746 | 34741613 |
Pericarditis | 18.29 | 10.93 | 25 | 205547 | 11620 | 34739739 |
Tachycardia | 18.25 | 10.93 | 370 | 205202 | 84402 | 34666957 |
Sedation | 18.12 | 10.93 | 63 | 205509 | 20943 | 34730416 |
Paraesthesia | 18.10 | 10.93 | 500 | 205072 | 63672 | 34687687 |
Renal impairment neonatal | 18.01 | 10.93 | 6 | 205566 | 13 | 34751346 |
Paraesthesia oral | 17.98 | 10.93 | 60 | 205512 | 4137 | 34747222 |
Blood glucose abnormal | 17.93 | 10.93 | 76 | 205496 | 5876 | 34745483 |
Chronic kidney disease | 17.83 | 10.93 | 341 | 205231 | 40869 | 34710490 |
Swelling | 17.80 | 10.93 | 349 | 205223 | 42017 | 34709342 |
Electrocardiogram change | 17.78 | 10.93 | 21 | 205551 | 661 | 34750698 |
Blood bilirubin increased | 17.74 | 10.93 | 142 | 205430 | 38154 | 34713205 |
Haemorrhage intracranial | 17.70 | 10.93 | 157 | 205415 | 15789 | 34735570 |
Gastric cancer | 17.57 | 10.93 | 8 | 205564 | 6461 | 34744898 |
Lymphoma | 17.57 | 10.93 | 29 | 205543 | 12478 | 34738881 |
Stridor | 17.47 | 10.93 | 43 | 205529 | 2491 | 34748868 |
Renal artery stenosis | 17.35 | 10.93 | 40 | 205532 | 2221 | 34749138 |
Acquired acrodermatitis enteropathica | 17.27 | 10.93 | 5 | 205567 | 5 | 34751354 |
Neutrophil count increased | 17.21 | 10.93 | 48 | 205524 | 17098 | 34734261 |
Blood alkaline phosphatase increased | 17.16 | 10.93 | 110 | 205462 | 31065 | 34720294 |
Hepatitis cholestatic | 17.10 | 10.93 | 13 | 205559 | 7934 | 34743425 |
Myelodysplastic syndrome | 16.98 | 10.93 | 57 | 205515 | 19151 | 34732208 |
Hepatic failure | 16.95 | 10.93 | 126 | 205446 | 34405 | 34716954 |
Blood pressure fluctuation | 16.64 | 10.93 | 84 | 205488 | 25165 | 34726194 |
Sleep disorder due to a general medical condition | 16.63 | 10.93 | 5 | 205567 | 5216 | 34746143 |
Neutropenic sepsis | 16.61 | 10.93 | 35 | 205537 | 13732 | 34737627 |
Spur cell anaemia | 16.60 | 10.93 | 8 | 205564 | 58 | 34751301 |
Systemic infection | 16.59 | 10.93 | 5 | 205567 | 5207 | 34746152 |
Arteriosclerosis coronary artery | 16.57 | 10.93 | 128 | 205444 | 12357 | 34739002 |
Cholangitis | 16.52 | 10.93 | 16 | 205556 | 8673 | 34742686 |
Dizziness postural | 16.52 | 10.93 | 76 | 205496 | 6088 | 34745271 |
Eye swelling | 16.49 | 10.93 | 108 | 205464 | 9887 | 34741472 |
Carcinoid tumour of the gastrointestinal tract | 16.37 | 10.93 | 8 | 205564 | 60 | 34751299 |
Circulatory collapse | 16.26 | 10.93 | 66 | 205506 | 20972 | 34730387 |
Essential hypertension | 16.23 | 10.93 | 47 | 205525 | 3001 | 34748358 |
Hypogammaglobulinaemia | 16.23 | 10.93 | 13 | 205559 | 7727 | 34743632 |
Stent placement | 16.21 | 10.93 | 66 | 205506 | 5012 | 34746347 |
Pemphigus | 16.15 | 10.93 | 32 | 205540 | 1599 | 34749760 |
Oedema mouth | 16.14 | 10.93 | 28 | 205544 | 1263 | 34750096 |
Generalised tonic-clonic seizure | 16.00 | 10.93 | 67 | 205505 | 21107 | 34730252 |
Inflammation | 16.00 | 10.93 | 99 | 205473 | 28196 | 34723163 |
Psychomotor hyperactivity | 15.79 | 10.93 | 20 | 205552 | 9602 | 34741757 |
Respiratory tract infection | 15.76 | 10.93 | 61 | 205511 | 19651 | 34731708 |
Hepatitis acute | 15.65 | 10.93 | 13 | 205559 | 7588 | 34743771 |
Respiratory tract oedema | 15.60 | 10.93 | 15 | 205557 | 371 | 34750988 |
Benign gastrointestinal neoplasm | 15.47 | 10.93 | 10 | 205562 | 135 | 34751224 |
Complications of transplanted kidney | 15.45 | 10.93 | 4 | 205568 | 4605 | 34746754 |
Device related infection | 15.34 | 10.93 | 51 | 205521 | 17186 | 34734173 |
Speech disorder | 15.33 | 10.93 | 224 | 205348 | 25462 | 34725897 |
Colitis ulcerative | 15.31 | 10.93 | 48 | 205524 | 16472 | 34734887 |
Delirium | 15.31 | 10.93 | 175 | 205397 | 43816 | 34707543 |
Overdose | 15.26 | 10.93 | 413 | 205159 | 90646 | 34660713 |
Rash | 15.08 | 10.93 | 1513 | 204059 | 221239 | 34530120 |
Encephalopathy | 14.99 | 10.93 | 134 | 205438 | 35185 | 34716174 |
Urine oxalate increased | 14.96 | 10.93 | 5 | 205567 | 11 | 34751348 |
Peripheral vascular disorder | 14.94 | 10.93 | 64 | 205508 | 4972 | 34746387 |
Diabetic foot infection | 14.63 | 10.93 | 19 | 205553 | 660 | 34750699 |
Tympanic membrane disorder | 14.61 | 10.93 | 7 | 205565 | 50 | 34751309 |
Extrapyramidal disorder | 14.51 | 10.93 | 34 | 205538 | 12846 | 34738513 |
Lymphomatoid papulosis | 14.48 | 10.93 | 11 | 205561 | 195 | 34751164 |
Cognitive disorder | 14.42 | 10.93 | 104 | 205468 | 28589 | 34722770 |
Pulmonary tuberculosis | 14.35 | 10.93 | 5 | 205567 | 4749 | 34746610 |
Diabetic autonomic neuropathy | 14.35 | 10.93 | 4 | 205568 | 3 | 34751356 |
Hypotonia | 14.32 | 10.93 | 15 | 205557 | 7838 | 34743521 |
Poisoning deliberate | 14.28 | 10.93 | 15 | 205557 | 7829 | 34743530 |
Chronic graft versus host disease | 14.27 | 10.93 | 4 | 205568 | 4369 | 34746990 |
BK virus infection | 14.23 | 10.93 | 8 | 205564 | 5730 | 34745629 |
Dyspnoea | 14.22 | 10.93 | 2470 | 203102 | 374312 | 34377047 |
Uveitis | 14.18 | 10.93 | 14 | 205558 | 7521 | 34743838 |
Anal fistula | 14.17 | 10.93 | 7 | 205565 | 5392 | 34745967 |
Carcinoid tumour of the stomach | 14.16 | 10.93 | 7 | 205565 | 54 | 34751305 |
Penile swelling | 14.14 | 10.93 | 21 | 205551 | 829 | 34750530 |
Kidney transplant rejection | 14.03 | 10.93 | 14 | 205558 | 7483 | 34743876 |
Inflammatory marker increased | 14 | 10.93 | 6 | 205566 | 5022 | 34746337 |
Gout | 14 | 10.93 | 174 | 205398 | 19079 | 34732280 |
Pneumatosis intestinalis | 13.95 | 10.93 | 3 | 205569 | 3920 | 34747439 |
Erectile dysfunction | 13.95 | 10.93 | 184 | 205388 | 20453 | 34730906 |
Cachexia | 13.94 | 10.93 | 13 | 205559 | 7173 | 34744186 |
Drug ineffective for unapproved indication | 13.92 | 10.93 | 82 | 205490 | 23633 | 34727726 |
Musculoskeletal chest pain | 13.91 | 10.93 | 103 | 205469 | 9815 | 34741544 |
Intestinal obstruction | 13.89 | 10.93 | 78 | 205494 | 22744 | 34728615 |
Endometriosis male | 13.87 | 10.93 | 5 | 205567 | 15 | 34751344 |
Psychomotor skills impaired | 13.86 | 10.93 | 3 | 205569 | 3903 | 34747456 |
Non-cardiac chest pain | 13.83 | 10.93 | 56 | 205516 | 4241 | 34747118 |
Liver abscess | 13.81 | 10.93 | 3 | 205569 | 3892 | 34747467 |
Postural orthostatic tachycardia syndrome | 13.70 | 10.93 | 8 | 205564 | 89 | 34751270 |
Gastrointestinal haemorrhage | 13.70 | 10.93 | 644 | 204928 | 87833 | 34663526 |
Acute myeloid leukaemia | 13.69 | 10.93 | 58 | 205514 | 18212 | 34733147 |
Alcoholic ketoacidosis | 13.63 | 10.93 | 5 | 205567 | 16 | 34751343 |
Renal tubular acidosis | 13.57 | 10.93 | 37 | 205535 | 2282 | 34749077 |
Infective pulmonary exacerbation of cystic fibrosis | 13.55 | 10.93 | 12 | 205560 | 6789 | 34744570 |
Toe amputation | 13.52 | 10.93 | 39 | 205533 | 2485 | 34748874 |
Adenovirus infection | 13.52 | 10.93 | 7 | 205565 | 5250 | 34746109 |
Jaundice | 13.51 | 10.93 | 121 | 205451 | 31761 | 34719598 |
Tenosynovitis | 13.47 | 10.93 | 5 | 205567 | 4565 | 34746794 |
Behaviour disorder | 13.45 | 10.93 | 6 | 205566 | 4904 | 34746455 |
Body temperature decreased | 13.45 | 10.93 | 36 | 205536 | 12998 | 34738361 |
Vomiting projectile | 13.37 | 10.93 | 18 | 205554 | 648 | 34750711 |
Cardiovascular disorder | 13.29 | 10.93 | 103 | 205469 | 9953 | 34741406 |
Haematochezia | 13.28 | 10.93 | 193 | 205379 | 46341 | 34705018 |
Blood sodium decreased | 13.20 | 10.93 | 150 | 205422 | 16101 | 34735258 |
Erythema multiforme | 13.16 | 10.93 | 19 | 205553 | 8630 | 34742729 |
Pollakiuria | 13.12 | 10.93 | 175 | 205397 | 19499 | 34731860 |
Myxoedema coma | 13.12 | 10.93 | 12 | 205560 | 278 | 34751081 |
Cataract nuclear | 13.10 | 10.93 | 16 | 205556 | 522 | 34750837 |
Ascites | 13.00 | 10.93 | 194 | 205378 | 46377 | 34704982 |
Epiglottic oedema | 12.99 | 10.93 | 10 | 205562 | 181 | 34751178 |
Hyperammonaemia | 12.97 | 10.93 | 11 | 205561 | 6356 | 34745003 |
Weaning failure | 12.96 | 10.93 | 11 | 205561 | 230 | 34751129 |
Enlarged uvula | 12.92 | 10.93 | 11 | 205561 | 231 | 34751128 |
Meningitis aseptic | 12.86 | 10.93 | 45 | 205527 | 3179 | 34748180 |
Arteriosclerosis | 12.85 | 10.93 | 117 | 205455 | 11851 | 34739508 |
Diverticulum | 12.83 | 10.93 | 79 | 205493 | 7080 | 34744279 |
Aggression | 12.79 | 10.93 | 157 | 205415 | 38807 | 34712552 |
Inappropriate schedule of product administration | 12.78 | 10.93 | 274 | 205298 | 62022 | 34689337 |
Death | 12.76 | 10.93 | 2102 | 203470 | 395947 | 34355412 |
Klebsiella infection | 12.72 | 10.93 | 19 | 205553 | 8512 | 34742847 |
Sleep attacks | 12.68 | 10.93 | 9 | 205563 | 143 | 34751216 |
Oesophageal carcinoma | 12.67 | 10.93 | 22 | 205550 | 9282 | 34742077 |
Drug level increased | 12.66 | 10.93 | 77 | 205495 | 22019 | 34729340 |
Glossodynia | 12.59 | 10.93 | 49 | 205523 | 3644 | 34747715 |
Organising pneumonia | 12.59 | 10.93 | 10 | 205562 | 5969 | 34745390 |
Shock | 12.57 | 10.93 | 206 | 205366 | 23973 | 34727386 |
Fistula | 12.54 | 10.93 | 13 | 205559 | 6827 | 34744532 |
Pulmonary arterial hypertension | 12.52 | 10.93 | 20 | 205552 | 8719 | 34742640 |
Pallor | 12.49 | 10.93 | 93 | 205479 | 25387 | 34725972 |
Adenocarcinoma pancreas | 12.47 | 10.93 | 26 | 205546 | 1348 | 34750011 |
Dilatation atrial | 12.44 | 10.93 | 33 | 205539 | 2002 | 34749357 |
Lipoedema | 12.43 | 10.93 | 3 | 205569 | 0 | 34751359 |
Alanine aminotransferase abnormal | 12.42 | 10.93 | 6 | 205566 | 4682 | 34746677 |
Faeces discoloured | 12.39 | 10.93 | 138 | 205434 | 14740 | 34736619 |
White blood cell count decreased | 12.32 | 10.93 | 448 | 205124 | 94997 | 34656362 |
Hypoglycaemic unconsciousness | 12.26 | 10.93 | 19 | 205553 | 779 | 34750580 |
Dermatitis atopic | 12.23 | 10.93 | 63 | 205509 | 5284 | 34746075 |
Cerebral infarction | 12.17 | 10.93 | 103 | 205469 | 27352 | 34724007 |
Terminal state | 12.12 | 10.93 | 4 | 205568 | 3930 | 34747429 |
Haemolysis | 12.10 | 10.93 | 18 | 205554 | 8076 | 34743283 |
Osteonecrosis of jaw | 12.08 | 10.93 | 59 | 205513 | 17830 | 34733529 |
Oral candidiasis | 12.08 | 10.93 | 34 | 205538 | 12076 | 34739283 |
Hepatic encephalopathy | 12.03 | 10.93 | 45 | 205527 | 14640 | 34736719 |
Albumin urine present | 12.01 | 10.93 | 13 | 205559 | 371 | 34750988 |
Therapy non-responder | 12.01 | 10.93 | 160 | 205412 | 38986 | 34712373 |
Loss of personal independence in daily activities | 11.94 | 10.93 | 131 | 205441 | 33048 | 34718311 |
Dystonia | 11.93 | 10.93 | 29 | 205543 | 10816 | 34740543 |
Acute coronary syndrome | 11.90 | 10.93 | 127 | 205445 | 13418 | 34737941 |
Acute cutaneous lupus erythematosus | 11.90 | 10.93 | 7 | 205565 | 79 | 34751280 |
Endotracheal intubation complication | 11.88 | 10.93 | 13 | 205559 | 376 | 34750983 |
Musculoskeletal stiffness | 11.83 | 10.93 | 198 | 205374 | 46482 | 34704877 |
Throat tightness | 11.83 | 10.93 | 87 | 205485 | 8271 | 34743088 |
Lip oedema | 11.77 | 10.93 | 38 | 205534 | 2575 | 34748784 |
Application site infection | 11.74 | 10.93 | 6 | 205566 | 50 | 34751309 |
Virologic failure | 11.71 | 10.93 | 3 | 205569 | 3477 | 34747882 |
Diabetic retinopathy | 11.66 | 10.93 | 30 | 205542 | 1787 | 34749572 |
Candida infection | 11.64 | 10.93 | 59 | 205513 | 17656 | 34733703 |
Psychotic disorder | 11.63 | 10.93 | 90 | 205482 | 24362 | 34726997 |
Osteoporosis | 11.61 | 10.93 | 37 | 205535 | 12631 | 34738728 |
Drug eruption | 11.58 | 10.93 | 69 | 205503 | 19829 | 34731530 |
Somnolence | 11.48 | 10.93 | 535 | 205037 | 110581 | 34640778 |
Atrial septal defect | 11.48 | 10.93 | 16 | 205556 | 7376 | 34743983 |
Pain in extremity | 11.45 | 10.93 | 878 | 204694 | 125635 | 34625724 |
Pneumopericardium | 11.44 | 10.93 | 8 | 205564 | 124 | 34751235 |
Pneumonia fungal | 11.40 | 10.93 | 15 | 205557 | 7085 | 34744274 |
Hypoventilation | 11.38 | 10.93 | 3 | 205569 | 3411 | 34747948 |
Anaesthesia | 11.35 | 10.93 | 6 | 205566 | 54 | 34751305 |
Malignant transformation | 11.35 | 10.93 | 19 | 205553 | 832 | 34750527 |
Rash pruritic | 11.33 | 10.93 | 222 | 205350 | 26719 | 34724640 |
Colorectal cancer | 11.30 | 10.93 | 7 | 205565 | 4754 | 34746605 |
Skin tightness | 11.29 | 10.93 | 34 | 205538 | 2219 | 34749140 |
Macroglossia | 11.29 | 10.93 | 13 | 205559 | 398 | 34750961 |
Meniere's disease | 11.26 | 10.93 | 6 | 205566 | 55 | 34751304 |
Suicide attempt | 11.24 | 10.93 | 162 | 205410 | 38954 | 34712405 |
Finger amputation | 11.23 | 10.93 | 9 | 205563 | 173 | 34751186 |
Contrast media reaction | 11.16 | 10.93 | 20 | 205552 | 926 | 34750433 |
Diabetic ketoacidosis | 11.05 | 10.93 | 158 | 205414 | 17874 | 34733485 |
Raynaud's phenomenon | 11.05 | 10.93 | 11 | 205561 | 284 | 34751075 |
Product monitoring error | 11.02 | 10.93 | 6 | 205566 | 4375 | 34746984 |
Neoplasm progression | 10.97 | 10.93 | 86 | 205486 | 23214 | 34728145 |
Electrocardiogram QT prolonged | 10.95 | 10.93 | 172 | 205400 | 40780 | 34710579 |
Enterococcal infection | 10.95 | 10.93 | 24 | 205548 | 9282 | 34742077 |
Hepatocellular carcinoma | 10.93 | 10.93 | 17 | 205555 | 7492 | 34743867 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Angioedema | 12191.35 | 9.70 | 6243 | 357827 | 69792 | 79310526 |
Myocardial infarction | 1331.23 | 9.70 | 2730 | 361340 | 181399 | 79198919 |
Cardiac failure congestive | 1286.64 | 9.70 | 2321 | 361749 | 140081 | 79240237 |
Hyperkalaemia | 798.76 | 9.70 | 1673 | 362397 | 112725 | 79267593 |
Swollen tongue | 773.33 | 9.70 | 963 | 363107 | 41607 | 79338711 |
Intestinal angioedema | 736.71 | 9.70 | 238 | 363832 | 645 | 79379673 |
Acute kidney injury | 706.30 | 9.70 | 4415 | 359655 | 514989 | 78865329 |
Coronary artery disease | 706.12 | 9.70 | 1155 | 362915 | 64319 | 79315999 |
Completed suicide | 658.39 | 9.70 | 2538 | 361532 | 243229 | 79137089 |
Cerebrovascular accident | 628.41 | 9.70 | 1843 | 362227 | 153449 | 79226869 |
Off label use | 581.07 | 9.70 | 2160 | 361910 | 905055 | 78475263 |
Lip swelling | 570.09 | 9.70 | 813 | 363257 | 40098 | 79340220 |
Drug abuse | 388.46 | 9.70 | 129 | 363941 | 162562 | 79217756 |
Acute myocardial infarction | 382.69 | 9.70 | 986 | 363084 | 76050 | 79304268 |
Drug ineffective | 368.42 | 9.70 | 3165 | 360905 | 1077748 | 78302570 |
Febrile neutropenia | 346.61 | 9.70 | 326 | 363744 | 230673 | 79149645 |
Pyrexia | 335.97 | 9.70 | 1777 | 362293 | 676932 | 78703386 |
Neutropenia | 257.70 | 9.70 | 583 | 363487 | 287127 | 79093191 |
Swelling face | 245.77 | 9.70 | 800 | 363270 | 70412 | 79309906 |
Hypotension | 243.41 | 9.70 | 3074 | 360996 | 437243 | 78943075 |
C-reactive protein increased | 204.34 | 9.70 | 173 | 363897 | 128854 | 79251464 |
Coronary arterial stent insertion | 204.22 | 9.70 | 190 | 363880 | 5854 | 79374464 |
Coronary artery bypass | 186.62 | 9.70 | 181 | 363889 | 5881 | 79374437 |
Lactic acidosis | 181.76 | 9.70 | 719 | 363351 | 69640 | 79310678 |
Interstitial lung disease | 180.73 | 9.70 | 149 | 363921 | 112451 | 79267867 |
Dehydration | 180.04 | 9.70 | 1828 | 362242 | 246359 | 79133959 |
Suspected suicide | 166.53 | 9.70 | 223 | 363847 | 10353 | 79369965 |
Hepatic function abnormal | 154.53 | 9.70 | 70 | 364000 | 73037 | 79307281 |
Renal failure | 153.84 | 9.70 | 1497 | 362573 | 199471 | 79180847 |
Pancreatitis | 148.46 | 9.70 | 664 | 363406 | 67911 | 79312407 |
Dizziness | 144.08 | 9.70 | 3279 | 360791 | 523162 | 78857156 |
Hypotensive transfusion reaction | 143.53 | 9.70 | 39 | 364031 | 41 | 79380277 |
Injury | 130.92 | 9.70 | 699 | 363371 | 76797 | 79303521 |
Hypovolaemia | 124.78 | 9.70 | 260 | 363810 | 17431 | 79362887 |
General physical health deterioration | 121.44 | 9.70 | 747 | 363323 | 274491 | 79105827 |
Myelosuppression | 119.63 | 9.70 | 20 | 364050 | 40276 | 79340042 |
Thrombocytopenia | 119.08 | 9.70 | 716 | 363354 | 264543 | 79115775 |
Infusion related reaction | 118.40 | 9.70 | 594 | 363476 | 229643 | 79150675 |
Drug intolerance | 117.47 | 9.70 | 715 | 363355 | 263404 | 79116914 |
Mental status changes | 116.56 | 9.70 | 609 | 363461 | 66350 | 79313968 |
Cytomegalovirus infection | 116.38 | 9.70 | 26 | 364044 | 42618 | 79337700 |
BRASH syndrome | 111.18 | 9.70 | 65 | 364005 | 952 | 79379366 |
Blood glucose increased | 109.27 | 9.70 | 898 | 363172 | 114077 | 79266241 |
Leukopenia | 107.55 | 9.70 | 232 | 363838 | 116281 | 79264037 |
Product dose omission issue | 105.32 | 9.70 | 1651 | 362419 | 245886 | 79134432 |
Sopor | 103.46 | 9.70 | 14 | 364056 | 32996 | 79347322 |
Chest pain | 100.44 | 9.70 | 1829 | 362241 | 280475 | 79099843 |
Synovitis | 98.34 | 9.70 | 355 | 363715 | 150379 | 79229939 |
Angina unstable | 93.06 | 9.70 | 222 | 363848 | 16305 | 79364013 |
Syncope | 92.61 | 9.70 | 1238 | 362832 | 178211 | 79202107 |
Agranulocytosis | 92.26 | 9.70 | 45 | 364025 | 44985 | 79335333 |
Septic shock | 90.58 | 9.70 | 274 | 363796 | 122527 | 79257791 |
Pharyngeal oedema | 89.93 | 9.70 | 217 | 363853 | 16055 | 79364263 |
Drug resistance | 89.86 | 9.70 | 40 | 364030 | 42173 | 79338145 |
Renal injury | 89.57 | 9.70 | 222 | 363848 | 16705 | 79363613 |
Blood pressure fluctuation | 88.04 | 9.70 | 106 | 363964 | 67039 | 79313279 |
Drug hypersensitivity | 87.95 | 9.70 | 1882 | 362188 | 297034 | 79083284 |
Therapeutic product effect incomplete | 86.94 | 9.70 | 342 | 363728 | 141303 | 79239015 |
Maternal exposure during pregnancy | 85.51 | 9.70 | 327 | 363743 | 136211 | 79244107 |
Altered state of consciousness | 85.02 | 9.70 | 47 | 364023 | 43775 | 79336543 |
Blood potassium increased | 84.51 | 9.70 | 310 | 363760 | 28965 | 79351353 |
Gastrointestinal haemorrhage | 84.19 | 9.70 | 1038 | 363032 | 146681 | 79233637 |
Asthenia | 82.37 | 9.70 | 2981 | 361089 | 508708 | 78871610 |
Infection | 80.63 | 9.70 | 710 | 363360 | 241002 | 79139316 |
Dysphagia | 79.27 | 9.70 | 880 | 363190 | 121256 | 79259062 |
Bronchopulmonary aspergillosis | 78.81 | 9.70 | 6 | 364064 | 22288 | 79358030 |
Neutrophil count decreased | 77.96 | 9.70 | 198 | 363872 | 93761 | 79286557 |
Cardiac disorder | 76.73 | 9.70 | 539 | 363531 | 65218 | 79315100 |
Cholestasis | 76.36 | 9.70 | 75 | 363995 | 52034 | 79328284 |
Myocardial ischaemia | 76.01 | 9.70 | 273 | 363797 | 25246 | 79355072 |
Type 2 diabetes mellitus | 75.53 | 9.70 | 483 | 363587 | 56639 | 79323679 |
Mucosal inflammation | 75.27 | 9.70 | 144 | 363926 | 75436 | 79304882 |
Product use in unapproved indication | 75.12 | 9.70 | 755 | 363315 | 249604 | 79130714 |
Exposure during pregnancy | 75.05 | 9.70 | 225 | 363845 | 100907 | 79279411 |
Nasopharyngitis | 74.78 | 9.70 | 769 | 363301 | 253112 | 79127206 |
International normalised ratio increased | 74.29 | 9.70 | 650 | 363420 | 84071 | 79296247 |
Malignant neoplasm progression | 73.26 | 9.70 | 345 | 363725 | 135645 | 79244673 |
Tongue oedema | 73.24 | 9.70 | 123 | 363947 | 6994 | 79373324 |
Lower respiratory tract infection | 73.08 | 9.70 | 322 | 363748 | 128898 | 79251420 |
Contraindicated product administered | 72.89 | 9.70 | 421 | 363649 | 157117 | 79223201 |
Condition aggravated | 72.53 | 9.70 | 1738 | 362332 | 499386 | 78880932 |
Hypophagia | 72.42 | 9.70 | 403 | 363667 | 44964 | 79335354 |
Pancreatitis acute | 71.60 | 9.70 | 429 | 363641 | 49175 | 79331143 |
Product quality issue | 71.47 | 9.70 | 326 | 363744 | 33614 | 79346704 |
Coma | 69.03 | 9.70 | 232 | 363838 | 100417 | 79279901 |
Ischaemic cardiomyopathy | 68.80 | 9.70 | 125 | 363945 | 7570 | 79372748 |
Oxygen saturation decreased | 67.98 | 9.70 | 330 | 363740 | 128717 | 79251601 |
Blood urea increased | 67.91 | 9.70 | 418 | 363652 | 48372 | 79331946 |
Blood creatinine increased | 67.72 | 9.70 | 1039 | 363031 | 154018 | 79226300 |
Intentional self-injury | 67.02 | 9.70 | 32 | 364038 | 32387 | 79347931 |
Bone marrow failure | 66.66 | 9.70 | 81 | 363989 | 51026 | 79329292 |
Psoriasis | 65.87 | 9.70 | 662 | 363408 | 88925 | 79291393 |
Hepatocellular injury | 65.79 | 9.70 | 72 | 363998 | 47521 | 79332797 |
Hepatic cytolysis | 65.69 | 9.70 | 21 | 364049 | 27130 | 79353188 |
Blood cholesterol increased | 65.64 | 9.70 | 627 | 363443 | 83093 | 79297225 |
Blood pressure inadequately controlled | 65.23 | 9.70 | 108 | 363962 | 6069 | 79374249 |
Abortion spontaneous | 64.33 | 9.70 | 27 | 364043 | 29480 | 79350838 |
Electrocardiogram T wave peaked | 63.56 | 9.70 | 45 | 364025 | 930 | 79379388 |
Arthralgia | 63.05 | 9.70 | 2060 | 362010 | 569743 | 78810575 |
Premature delivery | 62.66 | 9.70 | 15 | 364055 | 23452 | 79356866 |
Pancytopenia | 62.03 | 9.70 | 472 | 363598 | 165273 | 79215045 |
Transient ischaemic attack | 61.51 | 9.70 | 432 | 363638 | 52263 | 79328055 |
Labile blood pressure | 61.47 | 9.70 | 63 | 364007 | 2190 | 79378128 |
Erythema | 59.10 | 9.70 | 693 | 363377 | 222597 | 79157721 |
Depressed level of consciousness | 57.63 | 9.70 | 236 | 363834 | 96416 | 79283902 |
Pneumocystis jirovecii pneumonia | 57.31 | 9.70 | 39 | 364031 | 32469 | 79347849 |
Cytokine release syndrome | 57.29 | 9.70 | 48 | 364022 | 35950 | 79344368 |
Epilepsy | 56.27 | 9.70 | 62 | 364008 | 40798 | 79339520 |
Renal tubular necrosis | 56.10 | 9.70 | 245 | 363825 | 24794 | 79355524 |
Aspergillus infection | 55.80 | 9.70 | 10 | 364060 | 19151 | 79361167 |
Hepatotoxicity | 55.48 | 9.70 | 93 | 363977 | 51259 | 79329059 |
Joint swelling | 54.82 | 9.70 | 957 | 363113 | 287689 | 79092629 |
Hepatitis | 54.77 | 9.70 | 107 | 363963 | 55620 | 79324698 |
Toxic skin eruption | 54.37 | 9.70 | 17 | 364053 | 22276 | 79358042 |
Sedation | 54.23 | 9.70 | 96 | 363974 | 51799 | 79328519 |
Atrial fibrillation | 54.05 | 9.70 | 1233 | 362837 | 196653 | 79183665 |
Blood pressure diastolic abnormal | 53.84 | 9.70 | 11 | 364059 | 19191 | 79361127 |
Lymphopenia | 53.42 | 9.70 | 37 | 364033 | 30520 | 79349798 |
Therapy cessation | 53.02 | 9.70 | 323 | 363747 | 37239 | 79343079 |
Anhedonia | 52.85 | 9.70 | 169 | 363901 | 14729 | 79365589 |
Tenosynovitis | 52.75 | 9.70 | 5 | 364065 | 15549 | 79364769 |
Bradycardia | 52.33 | 9.70 | 890 | 363180 | 134667 | 79245651 |
Thrombotic microangiopathy | 51.72 | 9.70 | 14 | 364056 | 20155 | 79360163 |
Hyperlipidaemia | 51.53 | 9.70 | 246 | 363824 | 25847 | 79354471 |
Disseminated intravascular coagulation | 50.90 | 9.70 | 53 | 364017 | 35789 | 79344529 |
Lymphocyte count decreased | 50.76 | 9.70 | 86 | 363984 | 47203 | 79333115 |
Vascular graft | 50.42 | 9.70 | 54 | 364016 | 1977 | 79378341 |
Glycosylated haemoglobin increased | 49.86 | 9.70 | 197 | 363873 | 19063 | 79361255 |
Bronchiectasis | 49.59 | 9.70 | 20 | 364050 | 22366 | 79357952 |
Pneumonia | 49.27 | 9.70 | 2488 | 361582 | 657758 | 78722560 |
Alanine aminotransferase increased | 49.25 | 9.70 | 489 | 363581 | 162081 | 79218237 |
Shock | 49.08 | 9.70 | 354 | 363716 | 43194 | 79337124 |
Hypertensive emergency | 48.95 | 9.70 | 62 | 364008 | 2723 | 79377595 |
Fear | 48.40 | 9.70 | 214 | 363856 | 21772 | 79358546 |
Drug reaction with eosinophilia and systemic symptoms | 48.33 | 9.70 | 142 | 363928 | 64102 | 79316216 |
Chronic kidney disease | 48.22 | 9.70 | 488 | 363582 | 65666 | 79314652 |
Haematotoxicity | 47.65 | 9.70 | 7 | 364063 | 15512 | 79364806 |
Febrile bone marrow aplasia | 47.49 | 9.70 | 3 | 364067 | 13017 | 79367301 |
Gamma-glutamyltransferase increased | 47.10 | 9.70 | 113 | 363957 | 54567 | 79325751 |
Muscle spasms | 46.86 | 9.70 | 1086 | 362984 | 173644 | 79206674 |
Rheumatoid nodule | 46.85 | 9.70 | 11 | 364059 | 17427 | 79362891 |
Therapy partial responder | 46.69 | 9.70 | 11 | 364059 | 17386 | 79362932 |
Sedation complication | 46.02 | 9.70 | 8 | 364062 | 15661 | 79364657 |
Status epilepticus | 45.55 | 9.70 | 29 | 364041 | 25012 | 79355306 |
Immune reconstitution inflammatory syndrome | 45.51 | 9.70 | 5 | 364065 | 13836 | 79366482 |
Cardiomyopathy | 44.20 | 9.70 | 253 | 363817 | 28521 | 79351797 |
Arteriosclerosis | 43.66 | 9.70 | 182 | 363888 | 18045 | 79362273 |
Treatment failure | 43.61 | 9.70 | 533 | 363537 | 169953 | 79210365 |
Eosinophilia | 42.91 | 9.70 | 89 | 363981 | 45256 | 79335062 |
Product use issue | 41.98 | 9.70 | 689 | 363381 | 209133 | 79171185 |
Productive cough | 41.95 | 9.70 | 234 | 363836 | 88097 | 79292221 |
Nodular rash | 41.79 | 9.70 | 23 | 364047 | 298 | 79380020 |
Anaphylactic reaction | 41.63 | 9.70 | 574 | 363496 | 83169 | 79297149 |
Coronary artery occlusion | 41.56 | 9.70 | 159 | 363911 | 15156 | 79365162 |
Oedema mouth | 41.55 | 9.70 | 60 | 364010 | 2991 | 79377327 |
Rheumatic fever | 41.35 | 9.70 | 247 | 363823 | 28278 | 79352040 |
Cognitive disorder | 40.90 | 9.70 | 172 | 363898 | 69754 | 79310564 |
Haemophagocytic lymphohistiocytosis | 40.12 | 9.70 | 25 | 364045 | 21812 | 79358506 |
Body temperature decreased | 39.79 | 9.70 | 53 | 364017 | 32092 | 79348226 |
Gastrointestinal disorder | 39.38 | 9.70 | 362 | 363708 | 121843 | 79258475 |
Product complaint | 39.07 | 9.70 | 142 | 363928 | 13207 | 79367111 |
Haemorrhage intracranial | 38.74 | 9.70 | 228 | 363842 | 25965 | 79354353 |
Wheezing | 38.70 | 9.70 | 748 | 363322 | 115916 | 79264402 |
Blood lactate dehydrogenase increased | 38.67 | 9.70 | 75 | 363995 | 39095 | 79341223 |
Progressive multifocal leukoencephalopathy | 38.66 | 9.70 | 23 | 364047 | 20577 | 79359741 |
Pneumonitis | 38.58 | 9.70 | 145 | 363925 | 60715 | 79319603 |
Device interaction | 38.54 | 9.70 | 30 | 364040 | 720 | 79379598 |
Blood sodium decreased | 38.44 | 9.70 | 272 | 363798 | 32983 | 79347335 |
Sleep disorder due to general medical condition, insomnia type | 38.32 | 9.70 | 89 | 363981 | 43467 | 79336851 |
Tuberculosis | 38.13 | 9.70 | 11 | 364059 | 15187 | 79365131 |
Spinal stenosis | 38.08 | 9.70 | 158 | 363912 | 15633 | 79364685 |
Blood urea abnormal | 37.83 | 9.70 | 38 | 364032 | 1289 | 79379029 |
Osteoporosis | 37.60 | 9.70 | 124 | 363946 | 53988 | 79326330 |
Blood glucose decreased | 37.29 | 9.70 | 226 | 363844 | 26008 | 79354310 |
Blood pressure systolic abnormal | 37.25 | 9.70 | 16 | 364054 | 17231 | 79363087 |
Lymphomatoid papulosis | 37.12 | 9.70 | 22 | 364048 | 331 | 79379987 |
Blood electrolytes abnormal | 37.12 | 9.70 | 45 | 364025 | 1889 | 79378429 |
Panniculitis | 37.03 | 9.70 | 6 | 364064 | 12365 | 79367953 |
Drooling | 37.02 | 9.70 | 83 | 363987 | 5851 | 79374467 |
Gout | 36.97 | 9.70 | 216 | 363854 | 24533 | 79355785 |
Prescribed overdose | 36.57 | 9.70 | 297 | 363773 | 37586 | 79342732 |
Liver disorder | 36.52 | 9.70 | 188 | 363882 | 72229 | 79308089 |
Facet joint syndrome | 36.33 | 9.70 | 124 | 363946 | 11178 | 79369140 |
Blood pressure systolic increased | 36.02 | 9.70 | 170 | 363900 | 66816 | 79313502 |
Neurotoxicity | 35.96 | 9.70 | 58 | 364012 | 32460 | 79347858 |
Peripheral venous disease | 35.90 | 9.70 | 156 | 363914 | 15753 | 79364565 |
Dizziness postural | 35.63 | 9.70 | 125 | 363945 | 11424 | 79368894 |
Neuroleptic malignant syndrome | 35.60 | 9.70 | 44 | 364026 | 27515 | 79352803 |
Mydriasis | 35.58 | 9.70 | 18 | 364052 | 17625 | 79362693 |
Hyperthermia | 35.49 | 9.70 | 19 | 364051 | 18018 | 79362300 |
Lip dry | 35.41 | 9.70 | 152 | 363918 | 15266 | 79365052 |
Diarrhoea | 35.30 | 9.70 | 4561 | 359509 | 875928 | 78504390 |
Stomatitis | 35.23 | 9.70 | 465 | 363605 | 146292 | 79234026 |
Aplastic anaemia | 35.03 | 9.70 | 19 | 364051 | 17886 | 79362432 |
Red blood cell sedimentation rate increased | 34.95 | 9.70 | 101 | 363969 | 45841 | 79334477 |
Adjustment disorder with depressed mood | 34.94 | 9.70 | 106 | 363964 | 8980 | 79371338 |
Colitis ulcerative | 34.76 | 9.70 | 66 | 364004 | 34676 | 79345642 |
Transplant rejection | 34.69 | 9.70 | 23 | 364047 | 19414 | 79360904 |
Emotional distress | 34.69 | 9.70 | 306 | 363764 | 39663 | 79340655 |
Product substitution issue | 34.39 | 9.70 | 183 | 363887 | 20073 | 79360245 |
Arthropathy | 33.98 | 9.70 | 586 | 363484 | 176525 | 79203793 |
Inappropriate schedule of product administration | 33.70 | 9.70 | 419 | 363651 | 133209 | 79247109 |
Inflammation | 33.66 | 9.70 | 270 | 363800 | 93483 | 79286835 |
Liver injury | 33.61 | 9.70 | 401 | 363669 | 56213 | 79324105 |
Post transplant lymphoproliferative disorder | 33.35 | 9.70 | 6 | 364064 | 11458 | 79368860 |
Pathogen resistance | 33.12 | 9.70 | 12 | 364058 | 14330 | 79365988 |
Hyperbilirubinaemia | 32.89 | 9.70 | 38 | 364032 | 24480 | 79355838 |
Angina pectoris | 32.75 | 9.70 | 371 | 363699 | 51361 | 79328957 |
Laryngeal oedema | 32.36 | 9.70 | 96 | 363974 | 8033 | 79372285 |
Swollen joint count increased | 32.26 | 9.70 | 197 | 363873 | 22730 | 79357588 |
Product coating issue | 32.18 | 9.70 | 13 | 364057 | 78 | 79380240 |
Grip strength decreased | 32.11 | 9.70 | 190 | 363880 | 21679 | 79358639 |
Orbital myositis | 32.07 | 9.70 | 16 | 364054 | 167 | 79380151 |
Arterial occlusive disease | 31.90 | 9.70 | 98 | 363972 | 8358 | 79371960 |
Epstein-Barr virus infection | 31.74 | 9.70 | 13 | 364057 | 14403 | 79365915 |
Oral allergy syndrome | 31.51 | 9.70 | 13 | 364057 | 83 | 79380235 |
Sleep disorder due to a general medical condition | 31.23 | 9.70 | 13 | 364057 | 14264 | 79366054 |
Somatic delusion | 31.12 | 9.70 | 26 | 364044 | 692 | 79379626 |
Multiple organ dysfunction syndrome | 31.10 | 9.70 | 375 | 363695 | 119871 | 79260447 |
Cystitis haemorrhagic | 30.97 | 9.70 | 3 | 364067 | 9169 | 79371149 |
Systemic infection | 30.89 | 9.70 | 4 | 364066 | 9748 | 79370570 |
Vision blurred | 30.84 | 9.70 | 666 | 363404 | 105232 | 79275086 |
Graft versus host disease | 30.80 | 9.70 | 15 | 364055 | 15011 | 79365307 |
Body temperature increased | 30.71 | 9.70 | 102 | 363968 | 44318 | 79336000 |
Overdose | 30.54 | 9.70 | 625 | 363445 | 183581 | 79196737 |
Venoocclusive liver disease | 30.51 | 9.70 | 8 | 364062 | 11763 | 79368555 |
Stridor | 30.43 | 9.70 | 73 | 363997 | 5380 | 79374938 |
Rotator cuff repair | 30.32 | 9.70 | 40 | 364030 | 1830 | 79378488 |
Suicide attempt | 30.15 | 9.70 | 238 | 363832 | 82694 | 79297624 |
Aphthous ulcer | 30.12 | 9.70 | 20 | 364050 | 16869 | 79363449 |
Poisoning deliberate | 30.09 | 9.70 | 25 | 364045 | 18803 | 79361515 |
Drug dependence | 30.02 | 9.70 | 91 | 363979 | 40678 | 79339640 |
Hypoaesthesia | 30.01 | 9.70 | 1050 | 363020 | 178302 | 79202016 |
Pharyngeal swelling | 29.63 | 9.70 | 90 | 363980 | 7629 | 79372689 |
Blood parathyroid hormone decreased | 29.62 | 9.70 | 6 | 364064 | 10530 | 79369788 |
Accelerated hypertension | 29.56 | 9.70 | 25 | 364045 | 677 | 79379641 |
Pelvic mass | 29.54 | 9.70 | 32 | 364038 | 1187 | 79379131 |
Extrapyramidal disorder | 29.52 | 9.70 | 36 | 364034 | 22643 | 79357675 |
Diabetic ketoacidosis | 29.49 | 9.70 | 261 | 363809 | 33861 | 79346457 |
Cardiac failure | 29.48 | 9.70 | 513 | 363557 | 154329 | 79225989 |
Neutropenic sepsis | 29.25 | 9.70 | 49 | 364021 | 27015 | 79353303 |
Dilatation atrial | 29.17 | 9.70 | 57 | 364013 | 3647 | 79376671 |
Polyneuropathy | 28.71 | 9.70 | 41 | 364029 | 24110 | 79356208 |
Hypoglycaemia | 28.65 | 9.70 | 636 | 363434 | 100958 | 79279360 |
Gangrene | 28.51 | 9.70 | 98 | 363972 | 8866 | 79371452 |
Full blood count decreased | 28.50 | 9.70 | 215 | 363855 | 26604 | 79353714 |
Second primary malignancy | 28.41 | 9.70 | 15 | 364055 | 14335 | 79365983 |
Unresponsive to stimuli | 28.38 | 9.70 | 384 | 363686 | 55404 | 79324914 |
Chronic sinusitis | 28.27 | 9.70 | 12 | 364058 | 13014 | 79367304 |
Arteriosclerosis coronary artery | 28.26 | 9.70 | 158 | 363912 | 17658 | 79362660 |
Weight increased | 28.23 | 9.70 | 1009 | 363061 | 276377 | 79103941 |
Prostate cancer recurrent | 28.19 | 9.70 | 26 | 364044 | 792 | 79379526 |
Drug eruption | 27.63 | 9.70 | 105 | 363965 | 43830 | 79336488 |
Haemodialysis | 27.42 | 9.70 | 159 | 363911 | 18009 | 79362309 |
Erectile dysfunction | 27.34 | 9.70 | 136 | 363934 | 14528 | 79365790 |
Diabetic neuropathy | 27.25 | 9.70 | 76 | 363994 | 6140 | 79374178 |
Pancreatitis necrotising | 27.05 | 9.70 | 57 | 364013 | 3851 | 79376467 |
Nausea | 27.04 | 9.70 | 4862 | 359208 | 952334 | 78427984 |
Ventricular hypertrophy | 26.73 | 9.70 | 81 | 363989 | 6857 | 79373461 |
Hepatic enzyme increased | 26.70 | 9.70 | 632 | 363438 | 181978 | 79198340 |
Mouth swelling | 26.54 | 9.70 | 74 | 363996 | 5977 | 79374341 |
Lip oedema | 26.49 | 9.70 | 76 | 363994 | 6240 | 79374078 |
Caesarean section | 26.49 | 9.70 | 12 | 364058 | 12523 | 79367795 |
Oedema | 26.36 | 9.70 | 724 | 363346 | 118856 | 79261462 |
Generalised tonic-clonic seizure | 26.30 | 9.70 | 107 | 363963 | 43803 | 79336515 |
Platelet count decreased | 26.22 | 9.70 | 682 | 363388 | 193982 | 79186336 |
Foetal death | 26.21 | 9.70 | 3 | 364067 | 8041 | 79372277 |
Enterocolitis | 26.13 | 9.70 | 17 | 364053 | 14495 | 79365823 |
Herpes zoster | 26.13 | 9.70 | 285 | 363785 | 92798 | 79287520 |
Uveitis | 26.10 | 9.70 | 23 | 364047 | 16807 | 79363511 |
Memory impairment | 25.91 | 9.70 | 681 | 363389 | 111053 | 79269265 |
Pneumonia aspiration | 25.85 | 9.70 | 189 | 363881 | 66778 | 79313540 |
Rash maculo-papular | 25.84 | 9.70 | 150 | 363920 | 55928 | 79324390 |
Rhabdomyolysis | 25.81 | 9.70 | 635 | 363435 | 102496 | 79277822 |
Similar reaction on previous exposure to drug | 25.78 | 9.70 | 12 | 364058 | 106 | 79380212 |
Transaminases increased | 25.71 | 9.70 | 135 | 363935 | 51608 | 79328710 |
COVID-19 | 25.53 | 9.70 | 537 | 363533 | 157137 | 79223181 |
Aplasia | 25.27 | 9.70 | 3 | 364067 | 7817 | 79372501 |
Aspartate aminotransferase increased | 25.23 | 9.70 | 463 | 363607 | 138178 | 79242140 |
Intentional dose omission | 25.14 | 9.70 | 93 | 363977 | 8724 | 79371594 |
Therapeutic product effect decreased | 25.11 | 9.70 | 563 | 363507 | 163300 | 79217018 |
Fibromyalgia | 25.02 | 9.70 | 423 | 363647 | 63917 | 79316401 |
Ill-defined disorder | 24.91 | 9.70 | 187 | 363883 | 65688 | 79314630 |
Atrioventricular block first degree | 24.84 | 9.70 | 118 | 363952 | 12373 | 79367945 |
Unintentional medical device removal | 24.82 | 9.70 | 3 | 364067 | 7709 | 79372609 |
Diabetic foot infection | 24.66 | 9.70 | 24 | 364046 | 783 | 79379535 |
Cytomegalovirus viraemia | 24.51 | 9.70 | 14 | 364056 | 12807 | 79367511 |
Potassium wasting nephropathy | 24.42 | 9.70 | 13 | 364057 | 157 | 79380161 |
Gastric cancer | 24.40 | 9.70 | 8 | 364062 | 10171 | 79370147 |
Blood loss anaemia | 24.28 | 9.70 | 137 | 363933 | 15361 | 79364957 |
Oral herpes | 24.23 | 9.70 | 56 | 364014 | 27398 | 79352920 |
Ulnar nerve palsy | 24.20 | 9.70 | 7 | 364063 | 11 | 79380307 |
Depression | 24.16 | 9.70 | 1216 | 362854 | 215574 | 79164744 |
Cardiac arrest | 24.12 | 9.70 | 988 | 363082 | 171108 | 79209210 |
Fall | 24.01 | 9.70 | 2560 | 361510 | 485069 | 78895249 |
Blood pressure increased | 23.85 | 9.70 | 1187 | 362883 | 210173 | 79170145 |
Factor VII deficiency | 23.69 | 9.70 | 8 | 364062 | 26 | 79380292 |
Upper gastrointestinal haemorrhage | 23.65 | 9.70 | 291 | 363779 | 41089 | 79339229 |
Essential hypertension | 23.63 | 9.70 | 71 | 363999 | 5982 | 79374336 |
Dysphonia | 23.63 | 9.70 | 378 | 363692 | 56494 | 79323824 |
Dry mouth | 23.56 | 9.70 | 547 | 363523 | 87472 | 79292846 |
Hypogammaglobulinaemia | 23.56 | 9.70 | 15 | 364055 | 12936 | 79367382 |
Myelodysplastic syndrome | 23.50 | 9.70 | 66 | 364004 | 30235 | 79350083 |
Drug-induced liver injury | 23.46 | 9.70 | 191 | 363879 | 65926 | 79314392 |
Acute myeloid leukaemia | 23.42 | 9.70 | 68 | 364002 | 30817 | 79349501 |
Mouth ulceration | 23.35 | 9.70 | 93 | 363977 | 38301 | 79342017 |
Atrioventricular block second degree | 23.31 | 9.70 | 80 | 363990 | 7232 | 79373086 |
Peripheral vascular disorder | 23.14 | 9.70 | 85 | 363985 | 7945 | 79372373 |
Hepatic ischaemia | 23.14 | 9.70 | 27 | 364043 | 1088 | 79379230 |
Pulmonary tuberculosis | 23.13 | 9.70 | 4 | 364066 | 7861 | 79372457 |
Immunodeficiency | 22.98 | 9.70 | 40 | 364030 | 21728 | 79358590 |
Unevaluable event | 22.93 | 9.70 | 369 | 363701 | 55216 | 79325102 |
Dermatitis exfoliative generalised | 22.86 | 9.70 | 3 | 364067 | 7238 | 79373080 |
Metabolic acidosis | 22.75 | 9.70 | 515 | 363555 | 82014 | 79298304 |
Non-cardiac chest pain | 22.73 | 9.70 | 95 | 363975 | 9429 | 79370889 |
Azotaemia | 22.52 | 9.70 | 86 | 363984 | 8190 | 79372128 |
Osteonecrosis of jaw | 22.48 | 9.70 | 111 | 363959 | 43115 | 79337203 |
Mitral valve incompetence | 22.41 | 9.70 | 214 | 363856 | 28351 | 79351967 |
Dislocation of vertebra | 22.37 | 9.70 | 83 | 363987 | 7797 | 79372521 |
Toxic epidermal necrolysis | 22.32 | 9.70 | 116 | 363954 | 44465 | 79335853 |
Stent placement | 22.26 | 9.70 | 73 | 363997 | 6447 | 79373871 |
Asthma | 22.20 | 9.70 | 459 | 363611 | 134636 | 79245682 |
Alopecia | 22.09 | 9.70 | 848 | 363222 | 230507 | 79149811 |
Myalgia | 22.09 | 9.70 | 1048 | 363022 | 184593 | 79195725 |
Anaemia | 21.98 | 9.70 | 1741 | 362329 | 443274 | 78937044 |
Dystonia | 21.98 | 9.70 | 40 | 364030 | 21359 | 79358959 |
Encephalitis | 21.91 | 9.70 | 21 | 364049 | 14739 | 79365579 |
Electrocardiogram T wave abnormal | 21.90 | 9.70 | 51 | 364019 | 3687 | 79376631 |
Oropharyngeal pain | 21.88 | 9.70 | 359 | 363711 | 108994 | 79271324 |
Amnesia | 21.83 | 9.70 | 407 | 363663 | 62650 | 79317668 |
No reaction on previous exposure to drug | 21.78 | 9.70 | 14 | 364056 | 245 | 79380073 |
Torsade de pointes | 21.76 | 9.70 | 157 | 363913 | 19155 | 79361163 |
Enthesopathy | 21.73 | 9.70 | 13 | 364057 | 11595 | 79368723 |
Acute coronary syndrome | 21.66 | 9.70 | 168 | 363902 | 20965 | 79359353 |
Systemic lupus erythematosus | 21.60 | 9.70 | 406 | 363664 | 120743 | 79259575 |
Ageusia | 21.59 | 9.70 | 140 | 363930 | 16492 | 79363826 |
Hypertension | 21.58 | 9.70 | 1773 | 362297 | 329219 | 79051099 |
Device related infection | 21.54 | 9.70 | 82 | 363988 | 34212 | 79346106 |
Pulmonary renal syndrome | 21.39 | 9.70 | 20 | 364050 | 620 | 79379698 |
Raynaud's phenomenon | 21.32 | 9.70 | 25 | 364045 | 1013 | 79379305 |
Anal abscess | 21.31 | 9.70 | 8 | 364062 | 9347 | 79370971 |
Oral candidiasis | 21.20 | 9.70 | 67 | 364003 | 29561 | 79350757 |
Dysgeusia | 21.18 | 9.70 | 373 | 363697 | 56804 | 79323514 |
Eczema | 21.13 | 9.70 | 105 | 363965 | 40713 | 79339605 |
Muscle relaxant therapy | 21.12 | 9.70 | 12 | 364058 | 166 | 79380152 |
Intentional product use issue | 20.72 | 9.70 | 532 | 363538 | 151580 | 79228738 |
Sight disability | 20.72 | 9.70 | 11 | 364059 | 132 | 79380186 |
Penile swelling | 20.72 | 9.70 | 20 | 364050 | 646 | 79379672 |
Conjunctivitis | 20.70 | 9.70 | 55 | 364015 | 25660 | 79354658 |
Suspected suicide attempt | 20.66 | 9.70 | 15 | 364055 | 323 | 79379995 |
Pseudomonas infection | 20.66 | 9.70 | 40 | 364030 | 20863 | 79359455 |
Schizophrenia | 20.64 | 9.70 | 24 | 364046 | 15416 | 79364902 |
Infective pulmonary exacerbation of cystic fibrosis | 20.62 | 9.70 | 17 | 364053 | 12834 | 79367484 |
Speech disorder | 20.47 | 9.70 | 356 | 363714 | 54089 | 79326229 |
Pregnancy | 20.45 | 9.70 | 59 | 364011 | 26792 | 79353526 |
Concomitant disease aggravated | 20.41 | 9.70 | 18 | 364052 | 13149 | 79367169 |
Oedema genital | 20.38 | 9.70 | 19 | 364051 | 587 | 79379731 |
Eosinophil count increased | 20.37 | 9.70 | 29 | 364041 | 17076 | 79363242 |
Appendicitis | 20.37 | 9.70 | 40 | 364030 | 20754 | 79359564 |
Candida infection | 19.95 | 9.70 | 98 | 363972 | 38116 | 79342202 |
Acne | 19.80 | 9.70 | 61 | 364009 | 27129 | 79353189 |
Blood pressure diastolic decreased | 19.80 | 9.70 | 71 | 363999 | 30145 | 79350173 |
Product monitoring error | 19.66 | 9.70 | 8 | 364062 | 8898 | 79371420 |
Miosis | 19.57 | 9.70 | 26 | 364044 | 15763 | 79364555 |
Device expulsion | 19.57 | 9.70 | 57 | 364013 | 25804 | 79354514 |
Alanine aminotransferase abnormal | 19.51 | 9.70 | 8 | 364062 | 8859 | 79371459 |
Respiratory tract infection | 19.48 | 9.70 | 136 | 363934 | 48553 | 79331765 |
Thermohypoaesthesia | 19.44 | 9.70 | 10 | 364060 | 112 | 79380206 |
Feeling abnormal | 19.42 | 9.70 | 901 | 363169 | 158298 | 79222020 |
Premature labour | 19.41 | 9.70 | 7 | 364063 | 8383 | 79371935 |
Substance abuse | 19.41 | 9.70 | 12 | 364058 | 10514 | 79369804 |
Tachycardia | 19.38 | 9.70 | 641 | 363429 | 177127 | 79203191 |
Rheumatoid arthritis | 19.27 | 9.70 | 767 | 363303 | 207703 | 79172615 |
Graft versus host disease in gastrointestinal tract | 19.21 | 9.70 | 3 | 364067 | 6353 | 79373965 |
Dialysis | 19.05 | 9.70 | 147 | 363923 | 18315 | 79362003 |
Withdrawal hypertension | 18.95 | 9.70 | 15 | 364055 | 369 | 79379949 |
Hypoaldosteronism | 18.88 | 9.70 | 15 | 364055 | 371 | 79379947 |
Carcinoid tumour of the gastrointestinal tract | 18.82 | 9.70 | 9 | 364061 | 85 | 79380233 |
Electrocardiogram change | 18.80 | 9.70 | 26 | 364044 | 1245 | 79379073 |
Ovarian cyst | 18.79 | 9.70 | 18 | 364052 | 12637 | 79367681 |
Chronic graft versus host disease | 18.77 | 9.70 | 4 | 364066 | 6777 | 79373541 |
Chronic obstructive pulmonary disease | 18.77 | 9.70 | 517 | 363553 | 84902 | 79295416 |
Drug use disorder | 18.72 | 9.70 | 8 | 364062 | 8643 | 79371675 |
Anti-cyclic citrullinated peptide antibody | 18.63 | 9.70 | 64 | 364006 | 5788 | 79374530 |
Hand deformity | 18.61 | 9.70 | 348 | 363722 | 103571 | 79276747 |
Colitis ischaemic | 18.56 | 9.70 | 127 | 363943 | 15232 | 79365086 |
Ankylosing spondylitis | 18.54 | 9.70 | 17 | 364053 | 12188 | 79368130 |
Fistula | 18.53 | 9.70 | 19 | 364051 | 12921 | 79367397 |
Acquired acrodermatitis enteropathica | 18.53 | 9.70 | 5 | 364065 | 5 | 79380313 |
Posterior reversible encephalopathy syndrome | 18.41 | 9.70 | 60 | 364010 | 26221 | 79354097 |
Pulseless electrical activity | 18.26 | 9.70 | 119 | 363951 | 14041 | 79366277 |
Eye swelling | 18.22 | 9.70 | 193 | 363877 | 26275 | 79354043 |
Hepatitis B reactivation | 18.20 | 9.70 | 3 | 364067 | 6105 | 79374213 |
Sepsis | 18.19 | 9.70 | 1025 | 363045 | 268403 | 79111915 |
Joint range of motion decreased | 18.14 | 9.70 | 232 | 363838 | 33050 | 79347268 |
Hyponatraemia | 18.08 | 9.70 | 989 | 363081 | 176859 | 79203459 |
Pallor | 18.04 | 9.70 | 144 | 363926 | 49918 | 79330400 |
Adenovirus infection | 17.98 | 9.70 | 8 | 364062 | 8439 | 79371879 |
Treatment noncompliance | 17.97 | 9.70 | 337 | 363733 | 51931 | 79328387 |
Gait inability | 17.94 | 9.70 | 373 | 363697 | 58544 | 79321774 |
Diverticulum | 17.90 | 9.70 | 123 | 363947 | 14773 | 79365545 |
Oropharyngeal swelling | 17.74 | 9.70 | 26 | 364044 | 1314 | 79379004 |
BK virus infection | 17.73 | 9.70 | 9 | 364061 | 8795 | 79371523 |
Device dislocation | 17.70 | 9.70 | 60 | 364010 | 25910 | 79354408 |
Cytopenia | 17.65 | 9.70 | 42 | 364028 | 20341 | 79359977 |
Blood glucose abnormal | 17.63 | 9.70 | 95 | 363975 | 10471 | 79369847 |
Carotid artery stenosis | 17.61 | 9.70 | 83 | 363987 | 8675 | 79371643 |
Urethral prolapse | 17.58 | 9.70 | 4 | 364066 | 0 | 79380318 |
Benign gastrointestinal neoplasm | 17.56 | 9.70 | 10 | 364060 | 139 | 79380179 |
C-reactive protein abnormal | 17.49 | 9.70 | 139 | 363931 | 48228 | 79332090 |
Hyperammonaemia | 17.40 | 9.70 | 15 | 364055 | 11078 | 79369240 |
Pulmonary toxicity | 17.34 | 9.70 | 20 | 364050 | 12894 | 79367424 |
Disease progression | 17.32 | 9.70 | 677 | 363393 | 183685 | 79196633 |
Lethargy | 17.30 | 9.70 | 490 | 363580 | 80802 | 79299516 |
Blood immunoglobulin E increased | 17.28 | 9.70 | 3 | 364067 | 5879 | 79374439 |
Myxoedema coma | 17.26 | 9.70 | 19 | 364051 | 718 | 79379600 |
Nodule | 17.16 | 9.70 | 51 | 364019 | 22943 | 79357375 |
Haemolysis | 17.03 | 9.70 | 20 | 364050 | 12792 | 79367526 |
Cough | 16.98 | 9.70 | 1918 | 362152 | 364871 | 79015447 |
Hepatitis acute | 16.92 | 9.70 | 28 | 364042 | 15514 | 79364804 |
Lid lag | 16.87 | 9.70 | 8 | 364062 | 74 | 79380244 |
Labelled drug-drug interaction medication error | 16.80 | 9.70 | 67 | 364003 | 27583 | 79352735 |
Gastrointestinal toxicity | 16.77 | 9.70 | 8 | 364062 | 8101 | 79372217 |
Glomerulonephritis membranous | 16.72 | 9.70 | 28 | 364042 | 1588 | 79378730 |
Acute respiratory distress syndrome | 16.71 | 9.70 | 125 | 363945 | 43942 | 79336376 |
Renal artery stenosis | 16.69 | 9.70 | 44 | 364026 | 3438 | 79376880 |
Spur cell anaemia | 16.67 | 9.70 | 9 | 364061 | 112 | 79380206 |
Abnormal dreams | 16.66 | 9.70 | 99 | 363971 | 11313 | 79369005 |
Peripheral sensory neuropathy | 16.63 | 9.70 | 21 | 364049 | 13012 | 79367306 |
Paradoxical drug reaction | 16.61 | 9.70 | 6 | 364064 | 7179 | 79373139 |
End stage renal disease | 16.56 | 9.70 | 104 | 363966 | 12116 | 79368202 |
Breast cancer stage I | 16.53 | 9.70 | 5 | 364065 | 6695 | 79373623 |
Joint effusion | 16.50 | 9.70 | 36 | 364034 | 17978 | 79362340 |
Refusal of treatment by patient | 16.49 | 9.70 | 83 | 363987 | 8908 | 79371410 |
Haematochezia | 16.48 | 9.70 | 291 | 363779 | 87354 | 79292964 |
Fatigue | 16.41 | 9.70 | 4621 | 359449 | 925106 | 78455212 |
Respiratory distress | 16.37 | 9.70 | 365 | 363705 | 57974 | 79322344 |
Abortion induced | 16.33 | 9.70 | 6 | 364064 | 7103 | 79373215 |
Body height decreased | 16.30 | 9.70 | 80 | 363990 | 8500 | 79371818 |
Deep vein thrombosis postoperative | 16.16 | 9.70 | 94 | 363976 | 10658 | 79369660 |
Neutrophil count increased | 16.16 | 9.70 | 74 | 363996 | 29322 | 79350996 |
Adverse drug reaction | 16.08 | 9.70 | 407 | 363663 | 65985 | 79314333 |
Pre-eclampsia | 16.08 | 9.70 | 6 | 364064 | 7035 | 79373283 |
Poor venous access | 16.03 | 9.70 | 37 | 364033 | 18112 | 79362206 |
Skin toxicity | 16.01 | 9.70 | 9 | 364061 | 8305 | 79372013 |
Nephrogenic systemic fibrosis | 15.94 | 9.70 | 63 | 364007 | 6097 | 79374221 |
Dysarthria | 15.92 | 9.70 | 413 | 363657 | 67209 | 79313109 |
Faecal calprotectin increased | 15.90 | 9.70 | 3 | 364067 | 5538 | 79374780 |
Skin necrosis | 15.88 | 9.70 | 37 | 364033 | 18050 | 79362268 |
Facial nerve disorder | 15.85 | 9.70 | 18 | 364052 | 704 | 79379614 |
Drug tolerance | 15.84 | 9.70 | 10 | 364060 | 8665 | 79371653 |
Blood bilirubin increased | 15.83 | 9.70 | 210 | 363860 | 66022 | 79314296 |
Macroglossia | 15.76 | 9.70 | 23 | 364047 | 1158 | 79379160 |
Colorectal cancer | 15.75 | 9.70 | 10 | 364060 | 8637 | 79371681 |
Renal tubular acidosis | 15.66 | 9.70 | 44 | 364026 | 3570 | 79376748 |
Charles Bonnet syndrome | 15.62 | 9.70 | 5 | 364065 | 13 | 79380305 |
Female genital tract fistula | 15.60 | 9.70 | 4 | 364066 | 5971 | 79374347 |
Loss of personal independence in daily activities | 15.55 | 9.70 | 353 | 363717 | 102227 | 79278091 |
Adrenal insufficiency | 15.49 | 9.70 | 72 | 363998 | 28415 | 79351903 |
Tumour lysis syndrome | 15.19 | 9.70 | 57 | 364013 | 23882 | 79356436 |
Hypertensive heart disease | 15.18 | 9.70 | 48 | 364022 | 4158 | 79376160 |
Endometriosis male | 15.11 | 9.70 | 5 | 364065 | 15 | 79380303 |
Ileus paralytic | 15.10 | 9.70 | 13 | 364057 | 9607 | 79370711 |
Expired product administered | 15.04 | 9.70 | 68 | 364002 | 6983 | 79373335 |
Skin exfoliation | 14.92 | 9.70 | 343 | 363727 | 54757 | 79325561 |
Encephalomalacia | 14.89 | 9.70 | 23 | 364047 | 1218 | 79379100 |
Electrocardiogram QT prolonged | 14.87 | 9.70 | 307 | 363763 | 90079 | 79290239 |
Tonsillitis | 14.87 | 9.70 | 6 | 364064 | 6708 | 79373610 |
Alcoholic ketoacidosis | 14.87 | 9.70 | 5 | 364065 | 16 | 79380302 |
Asphyxia | 14.84 | 9.70 | 19 | 364051 | 11701 | 79368617 |
Hereditary angioedema with normal C1 esterase inhibitor | 14.82 | 9.70 | 4 | 364066 | 4 | 79380314 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 14.81 | 9.70 | 44 | 364026 | 3685 | 79376633 |
Pollakiuria | 14.75 | 9.70 | 246 | 363824 | 37071 | 79343247 |
Gait disturbance | 14.73 | 9.70 | 1119 | 362951 | 206387 | 79173931 |
Device difficult to use | 14.68 | 9.70 | 24 | 364046 | 13361 | 79366957 |
Psoriatic arthropathy | 14.66 | 9.70 | 463 | 363607 | 77536 | 79302782 |
Shock haemorrhagic | 14.61 | 9.70 | 45 | 364025 | 20015 | 79360303 |
Acute generalised exanthematous pustulosis | 14.59 | 9.70 | 36 | 364034 | 17218 | 79363100 |
Bone density decreased | 14.58 | 9.70 | 24 | 364046 | 13323 | 79366995 |
Neutropenic colitis | 14.56 | 9.70 | 4 | 364066 | 5703 | 79374615 |
Cardiomegaly | 14.49 | 9.70 | 184 | 363886 | 26168 | 79354150 |
Hypertransaminasaemia | 14.41 | 9.70 | 20 | 364050 | 11904 | 79368414 |
Occult blood positive | 14.40 | 9.70 | 66 | 364004 | 6817 | 79373501 |
Product prescribing error | 14.32 | 9.70 | 133 | 363937 | 44680 | 79335638 |
Osteoarthritis | 14.31 | 9.70 | 510 | 363560 | 86799 | 79293519 |
Pemphigoid | 14.20 | 9.70 | 119 | 363951 | 15196 | 79365122 |
Graft versus host disease in skin | 14.16 | 9.70 | 5 | 364065 | 6068 | 79374250 |
Hypertensive urgency | 14.14 | 9.70 | 15 | 364055 | 543 | 79379775 |
Penile contusion | 14.12 | 9.70 | 8 | 364062 | 110 | 79380208 |
Infusion site pain | 14.12 | 9.70 | 27 | 364043 | 14149 | 79366169 |
Liver abscess | 14.09 | 9.70 | 5 | 364065 | 6049 | 79374269 |
Gastric ulcer helicobacter | 14.01 | 9.70 | 5 | 364065 | 20 | 79380298 |
Blood glucose fluctuation | 13.93 | 9.70 | 64 | 364006 | 6618 | 79373700 |
Immune-mediated myositis | 13.85 | 9.70 | 41 | 364029 | 3426 | 79376892 |
Laryngotracheal oedema | 13.84 | 9.70 | 6 | 364064 | 44 | 79380274 |
Osmolar gap increased | 13.81 | 9.70 | 8 | 364062 | 115 | 79380203 |
Autoimmune disorder | 13.81 | 9.70 | 126 | 363944 | 16486 | 79363832 |
Sinus bradycardia | 13.76 | 9.70 | 176 | 363894 | 25071 | 79355247 |
Bone erosion | 13.75 | 9.70 | 39 | 364031 | 17808 | 79362510 |
Tricuspid valve incompetence | 13.69 | 9.70 | 144 | 363926 | 19568 | 79360750 |
Disturbance in social behaviour | 13.62 | 9.70 | 3 | 364067 | 4967 | 79375351 |
Frequent bowel movements | 13.62 | 9.70 | 79 | 363991 | 29460 | 79350858 |
Intestinal obstruction | 13.61 | 9.70 | 128 | 363942 | 42892 | 79337426 |
Creatinine renal clearance decreased | 13.58 | 9.70 | 43 | 364027 | 18959 | 79361359 |
Migraine | 13.57 | 9.70 | 300 | 363770 | 87193 | 79293125 |
Apathy | 13.56 | 9.70 | 24 | 364046 | 12953 | 79367365 |
Toe amputation | 13.54 | 9.70 | 44 | 364026 | 3867 | 79376451 |
Anxiety | 13.54 | 9.70 | 1314 | 362756 | 247198 | 79133120 |
Red cell distribution width increased | 13.52 | 9.70 | 31 | 364039 | 15211 | 79365107 |
Therapeutic response unexpected | 13.52 | 9.70 | 145 | 363925 | 19801 | 79360517 |
Mixed liver injury | 13.48 | 9.70 | 9 | 364061 | 7569 | 79372749 |
Rhinovirus infection | 13.42 | 9.70 | 10 | 364060 | 7943 | 79372375 |
Cerebral thrombosis | 13.37 | 9.70 | 32 | 364038 | 2355 | 79377963 |
Enlarged uvula | 13.29 | 9.70 | 13 | 364057 | 427 | 79379891 |
Pseudomembranous colitis | 13.28 | 9.70 | 4 | 364066 | 5370 | 79374948 |
Retching | 13.28 | 9.70 | 130 | 363940 | 17337 | 79362981 |
Diabetic autonomic neuropathy | 13.18 | 9.70 | 3 | 364067 | 0 | 79380318 |
Sleep attacks | 13.14 | 9.70 | 9 | 364061 | 176 | 79380142 |
Fracture | 13.14 | 9.70 | 53 | 364017 | 21748 | 79358570 |
Fear of injection | 13.13 | 9.70 | 9 | 364061 | 7465 | 79372853 |
Drug specific antibody present | 13.10 | 9.70 | 7 | 364063 | 6645 | 79373673 |
Cholelithiasis | 13.09 | 9.70 | 324 | 363746 | 52340 | 79327978 |
Neoplasm progression | 13.04 | 9.70 | 162 | 363908 | 51520 | 79328798 |
Sputum discoloured | 13.01 | 9.70 | 53 | 364017 | 21690 | 79358628 |
Oesophageal carcinoma | 12.99 | 9.70 | 19 | 364051 | 11065 | 79369253 |
Colitis | 12.96 | 9.70 | 246 | 363824 | 73061 | 79307257 |
Foetal disorder | 12.96 | 9.70 | 8 | 364062 | 130 | 79380188 |
Hypoglycaemic unconsciousness | 12.92 | 9.70 | 21 | 364049 | 1162 | 79379156 |
Pseudomonal sepsis | 12.91 | 9.70 | 6 | 364064 | 6168 | 79374150 |
Uvulitis | 12.90 | 9.70 | 4 | 364066 | 9 | 79380309 |
Diverticulum intestinal haemorrhagic | 12.89 | 9.70 | 44 | 364026 | 3967 | 79376351 |
Paraesthesia | 12.87 | 9.70 | 953 | 363117 | 175370 | 79204948 |
Drug dispensed to wrong patient | 12.86 | 9.70 | 16 | 364054 | 690 | 79379628 |
Lymphoma | 12.84 | 9.70 | 39 | 364031 | 17421 | 79362897 |
Rectal haemorrhage | 12.83 | 9.70 | 447 | 363623 | 75853 | 79304465 |
Neurological decompensation | 12.82 | 9.70 | 4 | 364066 | 5249 | 79375069 |
Psychomotor skills impaired | 12.76 | 9.70 | 4 | 364066 | 5233 | 79375085 |
Prostate examination abnormal | 12.75 | 9.70 | 9 | 364061 | 185 | 79380133 |
Confusional state | 12.75 | 9.70 | 1648 | 362422 | 316349 | 79063969 |
Therapeutic response shortened | 12.72 | 9.70 | 34 | 364036 | 15829 | 79364489 |
Coronary artery surgery | 12.71 | 9.70 | 9 | 364061 | 186 | 79380132 |
Sinus node dysfunction | 12.68 | 9.70 | 69 | 364001 | 7632 | 79372686 |
Dermatitis atopic | 12.66 | 9.70 | 84 | 363986 | 9972 | 79370346 |
Product physical issue | 12.66 | 9.70 | 45 | 364025 | 4140 | 79376178 |
Vitreous floaters | 12.62 | 9.70 | 66 | 364004 | 7190 | 79373128 |
Hypercholesterolaemia | 12.59 | 9.70 | 161 | 363909 | 22934 | 79357384 |
Therapeutic response decreased | 12.55 | 9.70 | 222 | 363848 | 66631 | 79313687 |
Cytomegalovirus colitis | 12.50 | 9.70 | 3 | 364067 | 4682 | 79375636 |
Fear of eating | 12.50 | 9.70 | 13 | 364057 | 460 | 79379858 |
Pharyngitis | 12.49 | 9.70 | 56 | 364014 | 22319 | 79357999 |
Pulse absent | 12.48 | 9.70 | 84 | 363986 | 10019 | 79370299 |
Lymphoproliferative disorder | 12.46 | 9.70 | 5 | 364065 | 5610 | 79374708 |
Fungal infection | 12.46 | 9.70 | 126 | 363944 | 41622 | 79338696 |
Nodal rhythm | 12.46 | 9.70 | 37 | 364033 | 3098 | 79377220 |
Seizure | 12.44 | 9.70 | 720 | 363350 | 188114 | 79192204 |
Bicytopenia | 12.44 | 9.70 | 3 | 364067 | 4667 | 79375651 |
Endotracheal intubation complication | 12.44 | 9.70 | 17 | 364053 | 805 | 79379513 |
Lacunar infarction | 12.38 | 9.70 | 57 | 364013 | 5900 | 79374418 |
Clonus | 12.33 | 9.70 | 8 | 364062 | 6832 | 79373486 |
Herpes simplex | 12.32 | 9.70 | 23 | 364047 | 12164 | 79368154 |
Musculoskeletal stiffness | 12.32 | 9.70 | 663 | 363407 | 174345 | 79205973 |
Skin odour abnormal | 12.31 | 9.70 | 29 | 364041 | 2112 | 79378206 |
Anaphylactic shock | 12.31 | 9.70 | 105 | 363965 | 35891 | 79344427 |
Pancreatitis haemorrhagic | 12.31 | 9.70 | 17 | 364053 | 813 | 79379505 |
Heart rate increased | 12.29 | 9.70 | 439 | 363631 | 120285 | 79260033 |
Exercise tolerance increased | 12.24 | 9.70 | 5 | 364065 | 31 | 79380287 |
Fluid intake reduced | 12.21 | 9.70 | 59 | 364011 | 6229 | 79374089 |
Granuloma | 12.09 | 9.70 | 12 | 364058 | 8285 | 79372033 |
Sinusitis | 12.07 | 9.70 | 750 | 363320 | 194751 | 79185567 |
Hepatic encephalopathy | 12.03 | 9.70 | 63 | 364007 | 24103 | 79356215 |
Metastases to lymph nodes | 12.01 | 9.70 | 18 | 364052 | 10379 | 79369939 |
Lupus vulgaris | 11.91 | 9.70 | 38 | 364032 | 3308 | 79377010 |
Oedema peripheral | 11.90 | 9.70 | 1321 | 362749 | 250967 | 79129351 |
Erythema multiforme | 11.88 | 9.70 | 41 | 364029 | 17610 | 79362708 |
Road traffic accident | 11.88 | 9.70 | 272 | 363798 | 43392 | 79336926 |
Finger deformity | 11.85 | 9.70 | 10 | 364060 | 7464 | 79372854 |
Depressed mood | 11.85 | 9.70 | 153 | 363917 | 48327 | 79331991 |
Hypertensive crisis | 11.84 | 9.70 | 146 | 363924 | 20624 | 79359694 |
COVID-19 pneumonia | 11.83 | 9.70 | 80 | 363990 | 28769 | 79351549 |
Heart rate decreased | 11.81 | 9.70 | 238 | 363832 | 70078 | 79310240 |
Multiple injuries | 11.81 | 9.70 | 39 | 364031 | 3456 | 79376862 |
Monocyte count increased | 11.80 | 9.70 | 19 | 364051 | 10642 | 79369676 |
Palatal swelling | 11.74 | 9.70 | 8 | 364062 | 155 | 79380163 |
Walking aid user | 11.73 | 9.70 | 83 | 363987 | 10065 | 79370253 |
Metastases to lung | 11.69 | 9.70 | 43 | 364027 | 18120 | 79362198 |
Transient psychosis | 11.68 | 9.70 | 6 | 364064 | 67 | 79380251 |
Product solubility abnormal | 11.64 | 9.70 | 18 | 364052 | 954 | 79379364 |
Respiratory tract oedema | 11.63 | 9.70 | 17 | 364053 | 857 | 79379461 |
Pulmonary fibrosis | 11.62 | 9.70 | 137 | 363933 | 43975 | 79336343 |
Body temperature | 11.61 | 9.70 | 5 | 364065 | 36 | 79380282 |
Pericarditis | 11.56 | 9.70 | 375 | 363695 | 103861 | 79276457 |
Albumin urine present | 11.54 | 9.70 | 15 | 364055 | 676 | 79379642 |
Pain in jaw | 11.52 | 9.70 | 145 | 363925 | 46006 | 79334312 |
Bundle branch block left | 11.51 | 9.70 | 91 | 363979 | 11422 | 79368896 |
Enterococcal infection | 11.50 | 9.70 | 35 | 364035 | 15625 | 79364693 |
Skin induration | 11.48 | 9.70 | 46 | 364024 | 4479 | 79375839 |
Somnolence | 11.46 | 9.70 | 937 | 363133 | 238044 | 79142274 |
Nasal congestion | 11.44 | 9.70 | 264 | 363806 | 76288 | 79304030 |
Hallucination, auditory | 11.43 | 9.70 | 52 | 364018 | 20641 | 79359677 |
Atrioventricular block | 11.42 | 9.70 | 106 | 363964 | 13935 | 79366383 |
Brain oedema | 11.41 | 9.70 | 68 | 364002 | 25195 | 79355123 |
Nasal polyps | 11.38 | 9.70 | 10 | 364060 | 7317 | 79373001 |
Transcription medication error | 11.26 | 9.70 | 12 | 364058 | 437 | 79379881 |
Small intestinal ulcer haemorrhage | 11.22 | 9.70 | 7 | 364063 | 116 | 79380202 |
Dyspnoea | 11.22 | 9.70 | 4211 | 359859 | 852814 | 78527504 |
Erythema marginatum | 11.21 | 9.70 | 4 | 364066 | 16 | 79380302 |
Hypoaesthesia oral | 11.17 | 9.70 | 106 | 363964 | 14018 | 79366300 |
Angiotensin converting enzyme inhibitor foetopathy | 11.17 | 9.70 | 5 | 364065 | 40 | 79380278 |
Lichen planus | 11.15 | 9.70 | 33 | 364037 | 2758 | 79377560 |
Breast cancer stage III | 11.14 | 9.70 | 80 | 363990 | 9746 | 79370572 |
Pulse volume decreased | 11.12 | 9.70 | 3 | 364067 | 3 | 79380315 |
Hospice care | 11.10 | 9.70 | 83 | 363987 | 10241 | 79370077 |
Subileus | 11.06 | 9.70 | 6 | 364064 | 5648 | 79374670 |
Hypoventilation | 11.05 | 9.70 | 10 | 364060 | 7214 | 79373104 |
Hepatocellular carcinoma | 11.04 | 9.70 | 15 | 364055 | 9006 | 79371312 |
Obesity | 10.90 | 9.70 | 223 | 363847 | 34902 | 79345416 |
Metastases to liver | 10.88 | 9.70 | 80 | 363990 | 28234 | 79352084 |
Spinal pain | 10.88 | 9.70 | 35 | 364035 | 15357 | 79364961 |
Complications of transplanted kidney | 10.74 | 9.70 | 8 | 364062 | 6358 | 79373960 |
Cardiac murmur | 10.71 | 9.70 | 115 | 363955 | 15709 | 79364609 |
Circumoral oedema | 10.67 | 9.70 | 10 | 364060 | 311 | 79380007 |
Cytomegalovirus test positive | 10.66 | 9.70 | 7 | 364063 | 5940 | 79374378 |
Cataract nuclear | 10.66 | 9.70 | 18 | 364052 | 1028 | 79379290 |
Electrocardiogram ST-T change | 10.60 | 9.70 | 23 | 364047 | 1586 | 79378732 |
Vasculitis | 10.60 | 9.70 | 69 | 364001 | 25033 | 79355285 |
Diffuse large B-cell lymphoma | 10.55 | 9.70 | 25 | 364045 | 12124 | 79368194 |
Vitritis infective | 10.50 | 9.70 | 4 | 364066 | 20 | 79380298 |
Malaise | 10.49 | 9.70 | 2024 | 362046 | 487845 | 78892473 |
Cerebellar syndrome | 10.45 | 9.70 | 6 | 364064 | 5474 | 79374844 |
Respiratory disorder | 10.44 | 9.70 | 143 | 363927 | 44713 | 79335605 |
Pain | 10.42 | 9.70 | 2959 | 361111 | 700843 | 78679475 |
Dilatation ventricular | 10.42 | 9.70 | 42 | 364028 | 4102 | 79376216 |
Metastases to bone | 10.39 | 9.70 | 67 | 364003 | 24360 | 79355958 |
Blood calcium decreased | 10.36 | 9.70 | 94 | 363976 | 31725 | 79348593 |
Retroperitoneal oedema | 10.34 | 9.70 | 4 | 364066 | 21 | 79380297 |
Dysaesthesia | 10.33 | 9.70 | 7 | 364063 | 5841 | 79374477 |
Carcinoid tumour of the stomach | 10.31 | 9.70 | 8 | 364062 | 191 | 79380127 |
Pneumopericardium | 10.28 | 9.70 | 8 | 364062 | 192 | 79380126 |
Drug level below therapeutic | 10.27 | 9.70 | 18 | 364052 | 9752 | 79370566 |
Toxic shock syndrome staphylococcal | 10.26 | 9.70 | 3 | 364067 | 5 | 79380313 |
Epiglottic oedema | 10.23 | 9.70 | 10 | 364060 | 328 | 79379990 |
Bradykinesia | 10.22 | 9.70 | 13 | 364057 | 8030 | 79372288 |
Eosinophilic pleural effusion | 10.21 | 9.70 | 10 | 364060 | 329 | 79379989 |
Muscle injury | 10.19 | 9.70 | 158 | 363912 | 48403 | 79331915 |
Muscular weakness | 10.14 | 9.70 | 859 | 363211 | 159870 | 79220448 |
Dyspnoea at rest | 10.14 | 9.70 | 11 | 364059 | 7291 | 79373027 |
Skin hypertrophy | 10.12 | 9.70 | 47 | 364023 | 4881 | 79375437 |
Deep vein thrombosis | 10.12 | 9.70 | 661 | 363409 | 120258 | 79260060 |
Gastrointestinal vascular malformation | 10.12 | 9.70 | 5 | 364065 | 51 | 79380267 |
Peripheral artery stenosis | 10.11 | 9.70 | 20 | 364050 | 1291 | 79379027 |
Urine sodium increased | 10.10 | 9.70 | 8 | 364062 | 197 | 79380121 |
Eosinophilic oesophagitis | 10.09 | 9.70 | 13 | 364057 | 581 | 79379737 |
Pulmonary arterial hypertension | 10.03 | 9.70 | 82 | 363988 | 28284 | 79352034 |
Intracranial pressure increased | 10.02 | 9.70 | 14 | 364056 | 8308 | 79372010 |
Brain abscess | 10.01 | 9.70 | 5 | 364065 | 4931 | 79375387 |
Jaundice cholestatic | 9.97 | 9.70 | 23 | 364047 | 11261 | 79369057 |
Cystitis | 9.94 | 9.70 | 175 | 363895 | 52557 | 79327761 |
Ludwig angina | 9.93 | 9.70 | 9 | 364061 | 268 | 79380050 |
Petit mal epilepsy | 9.92 | 9.70 | 7 | 364063 | 5720 | 79374598 |
Peritoneal fibrosis | 9.91 | 9.70 | 3 | 364067 | 6 | 79380312 |
Circulatory collapse | 9.91 | 9.70 | 117 | 363953 | 37551 | 79342767 |
Malignant transformation | 9.91 | 9.70 | 19 | 364051 | 1199 | 79379119 |
Pulmonary pain | 9.90 | 9.70 | 4 | 364066 | 4469 | 79375849 |
Transplant dysfunction | 9.89 | 9.70 | 11 | 364059 | 7210 | 79373108 |
Terminal state | 9.84 | 9.70 | 5 | 364065 | 4884 | 79375434 |
Impaired healing | 9.80 | 9.70 | 315 | 363755 | 87340 | 79292978 |
Prostatic specific antigen increased | 9.79 | 9.70 | 81 | 363989 | 10305 | 79370013 |
Kidney transplant rejection | 9.79 | 9.70 | 20 | 364050 | 10226 | 79370092 |
Cholangitis | 9.78 | 9.70 | 28 | 364042 | 12748 | 79367570 |
Contrast media reaction | 9.76 | 9.70 | 26 | 364044 | 2044 | 79378274 |
Meningitis | 9.76 | 9.70 | 18 | 364052 | 9564 | 79370754 |
Foot deformity | 9.75 | 9.70 | 67 | 364003 | 24007 | 79356311 |
Hepatic failure | 9.75 | 9.70 | 209 | 363861 | 61003 | 79319315 |
Psychiatric decompensation | 9.70 | 9.70 | 3 | 364067 | 3960 | 79376358 |
Conjunctival scar | 9.70 | 9.70 | 8 | 364062 | 209 | 79380109 |
None
Source | Code | Description |
---|---|---|
ATC | C09AA03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain |
ATC | C09BA03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and diuretics |
ATC | C09BB03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers |
ATC | C10BX07 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
MeSH PA | D000806 | Angiotensin-Converting Enzyme Inhibitors |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002316 | Cardiotonic Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D011480 | Protease Inhibitors |
MeSH PA | D020011 | Protective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Myocardial infarction | indication | 22298006 | DOID:5844 |
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Chronic heart failure | indication | 48447003 | |
Superficial Ocular Infection | indication | ||
Diabetic retinopathy | off-label use | 4855003 | DOID:8947 |
Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
Blepharoconjunctivitis | off-label use | 68659002 | DOID:2456 |
Dacryocystitis | off-label use | 85777005 | DOID:9938 |
Corneal ulcer | off-label use | 91514001 | DOID:8463 |
Diabetic renal disease | off-label use | 127013003 | |
Bacterial conjunctivitis | off-label use | 128350005 | DOID:9700 |
Acute scleroderma renal crisis | off-label use | 236503001 | |
Meibomianitis | off-label use | 309779001 | |
Infective blepharitis | off-label use | 312219000 | |
Bacterial keratitis | off-label use | 314557000 | |
Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
Nondiabetic Proteinuric Nephropathy | off-label use | ||
Migraine Prevention | off-label use | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Hypercholesterolemia | contraindication | 13644009 | |
Hyperkalemia | contraindication | 14140009 | |
Jaundice | contraindication | 18165001 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Hypovolemia | contraindication | 28560003 | |
Acute cerebrovascular insufficiency | contraindication | 29322000 | |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Immunosuppression | contraindication | 38013005 | |
Angioedema | contraindication | 41291007 | DOID:1558 |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Aortic valve stenosis | contraindication | 60573004 | DOID:1712 |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
Liver function tests abnormal | contraindication | 166603001 | |
Hypomagnesemia | contraindication | 190855004 | |
Acute hepatic failure | contraindication | 197270009 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Hypertrophic cardiomyopathy | contraindication | 233873004 | DOID:11984 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Disorder of electrolytes | contraindication | 237840007 | |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Renal artery stenosis | contraindication | 302233006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Azotemia | contraindication | 445009001 | |
Hemodialysis with High-Flux Membrane | contraindication | ||
Intestinal Angioedema | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.18 | acidic |
pKa2 | 3.18 | acidic |
pKa3 | 11.0 | Basic |
pKa4 | 6.95 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 10039800 | Nov. 6, 2035 | ACUTE MYOCARDIAL INFARCTION |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 10039800 | Nov. 6, 2035 | METHOD OF TREATING HYPERTENSION |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 10039800 | Nov. 6, 2035 | METHOD OF TREATMENT OF HEART FAILURE |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 10039800 | Nov. 6, 2035 | REDUCTION OF MORTALITY IN ACUTE MYOCARDIAL INFARCTION |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 10039800 | Nov. 6, 2035 | TREATMENT OF HEART FAILURE |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 10039800 | Nov. 6, 2035 | TREATMENT OF HYPERTENSION |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 10039800 | Nov. 6, 2035 | TREATMENT OF MYOCARDIAL INFARCTION |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 10406199 | Nov. 6, 2035 | ACUTE MYOCARDIAL INFARCTION |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 10406199 | Nov. 6, 2035 | METHOD OF TREATING HYPERTENSION |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 10406199 | Nov. 6, 2035 | METHOD OF TREATMENT OF HEART FAILURE |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 10406199 | Nov. 6, 2035 | REDUCTION OF MORTALITY IN ACUTE MYOCARDIAL INFARCTION |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 10406199 | Nov. 6, 2035 | TREATMENT OF HEART FAILURE |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 10406199 | Nov. 6, 2035 | TREATMENT OF HYPERTENSION |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 10406199 | Nov. 6, 2035 | TREATMENT OF MYOCARDIAL INFARCTION |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 9616096 | Nov. 6, 2035 | ACUTE MYOCARDIAL INFARCTION |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 9616096 | Nov. 6, 2035 | METHOD OF TREATING HYPERTENSION |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 9616096 | Nov. 6, 2035 | METHOD OF TREATMENT OF HEART FAILURE |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 9616096 | Nov. 6, 2035 | REDUCTION OF MORTALITY IN ACUTE MYOCARDIAL INFARCTION |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 9616096 | Nov. 6, 2035 | TREATMENT OF HEART FAILURE |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 9616096 | Nov. 6, 2035 | TREATMENT OF HYPERTENSION |
1MG/ML | QBRELIS | AZURITY | N208401 | July 29, 2016 | RX | SOLUTION | ORAL | 9616096 | Nov. 6, 2035 | TREATMENT OF MYOCARDIAL INFARCTION |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Angiotensin-converting enzyme | Enzyme | INHIBITOR | IC50 | 8.92 | WOMBAT-PK | CHEMBL | |||
Angiotensin-converting enzyme | Enzyme | Ki | 7.29 | CHEMBL |
ID | Source |
---|---|
4019380 | VUID |
N0000147537 | NUI |
D00362 | KEGG_DRUG |
4019380 | VANDF |
C0065374 | UMLSCUI |
CHEBI:6503 | CHEBI |
LPR | PDB_CHEM_ID |
CHEMBL1237 | ChEMBL_ID |
CHEMBL1729579 | ChEMBL_ID |
CHEMBL419213 | ChEMBL_ID |
D017706 | MESH_DESCRIPTOR_UI |
DB00722 | DRUGBANK_ID |
5362119 | PUBCHEM_CID |
6360 | IUPHAR_LIGAND_ID |
E7199S1YWR | UNII |
29046 | RXNORM |
31907 | MMSL |
44066 | MMSL |
4985 | MMSL |
d00732 | MMSL |
000658 | NDDF |
108575001 | SNOMEDCT_US |
341000220102 | SNOMEDCT_US |
386873009 | SNOMEDCT_US |
83915-83-7 | SECONDARY_CAS_RN |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Lisinopril with Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-1262 | TABLET | 10 mg | ORAL | ANDA | 24 sections |
Lisinopril with Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-1262 | TABLET | 10 mg | ORAL | ANDA | 24 sections |
Lisinopril with Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-1263 | TABLET | 20 mg | ORAL | ANDA | 24 sections |
Lisinopril with Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-1263 | TABLET | 20 mg | ORAL | ANDA | 24 sections |
Lisinopril with Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-1264 | TABLET | 20 mg | ORAL | ANDA | 24 sections |
Lisinopril with Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-1264 | TABLET | 20 mg | ORAL | ANDA | 24 sections |
Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9713 | TABLET | 20 mg | ORAL | ANDA | 26 sections |
Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9714 | TABLET | 10 mg | ORAL | ANDA | 26 sections |
Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9715 | TABLET | 5 mg | ORAL | ANDA | 26 sections |
lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0025 | TABLET | 2.50 mg | ORAL | ANDA | 25 sections |
lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0101 | TABLET | 10 mg | ORAL | ANDA | 25 sections |
lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0102 | TABLET | 20 mg | ORAL | ANDA | 25 sections |
lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0103 | TABLET | 30 mg | ORAL | ANDA | 25 sections |
lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0104 | TABLET | 40 mg | ORAL | ANDA | 25 sections |
Lisinopril and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0152 | TABLET | 20 mg | ORAL | ANDA | 22 sections |
Lisinopril and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0173 | TABLET | 20 mg | ORAL | ANDA | 22 sections |
lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0602 | TABLET | 2.50 mg | ORAL | ANDA | 25 sections |
lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0605 | TABLET | 5 mg | ORAL | ANDA | 25 sections |
lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0610 | TABLET | 10 mg | ORAL | ANDA | 25 sections |
lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0620 | TABLET | 20 mg | ORAL | ANDA | 25 sections |
lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0630 | TABLET | 30 mg | ORAL | ANDA | 25 sections |
lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0640 | TABLET | 40 mg | ORAL | ANDA | 25 sections |
lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-5400 | TABLET | 5 mg | ORAL | ANDA | 25 sections |
Lisinopril and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-7100 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-7674 | TABLET | 5 mg | ORAL | ANDA | 21 sections |
Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0405 | TABLET | 2.50 mg | ORAL | ANDA | 26 sections |
Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0405 | TABLET | 2.50 mg | ORAL | ANDA | 26 sections |
Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0406 | TABLET | 5 mg | ORAL | ANDA | 26 sections |
Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0406 | TABLET | 5 mg | ORAL | ANDA | 26 sections |
Lisinopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0407 | TABLET | 10 mg | ORAL | ANDA | 26 sections |