lisinopril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 1587 76547-98-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lisinopril
  • linopril
  • nanopril
  • lisinopril hydrate
  • lisinopril dihydrate
  • anhydrous lisinopril
One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.
  • Molecular weight: 405.50
  • Formula: C21H31N3O5
  • CLOGP: -1.82
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 4
  • TPSA: 132.96
  • ALOGS: -3.27
  • ROTB: 12
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 97 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 94 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.41 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 25 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.89 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 42 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.207 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.019 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.250 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 1.626 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 88.540 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 77.580 % High 1
herg hERG pIC50 5.151 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.057 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.304 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 88.260 % High 1
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK3,MAP2K6,MAP3K21,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PIK3CB,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 35
kinase-selectivity-class AXL,BRAF,EIF2AK3,EPHB4,GRK2,MAP2K6,MAPK7,STK33,TEK,TGFBR1 10
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.571 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.038 High 1
mh-clint Mouse hepatocyte intrinsic clearance 3.177 High 1
mppb Mouse plasma protein binding (% unbound) 92.900 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.879 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 91.460 % High 1
rat-kpuu-brain Rat brain Kpuu 0.003 % Moderate 0.69
rh-clint Rat hepatocyte intrinsic clearance 0.973 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 89.590 % High 1
rppb Rat plasma protein binding (% unbound) 90.950 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 859.014 uM High 1

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1987 FDA MERCK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Angioedema 1730.31 9.34 1706 370638 63170 90192933
Intestinal angioedema 796.32 9.34 244 372100 604 90255499
Cardiac failure congestive 526.94 9.34 1217 371127 97477 90158626
Myocardial infarction 460.95 9.34 1208 371136 104764 90151339
Drug ineffective 421.47 9.34 3656 368688 1380642 88875461
Swollen tongue 398.56 9.34 694 371650 45262 90210841
Off label use 380.62 9.34 2812 369532 1099440 89156663
Cerebrovascular accident 360.85 9.34 1223 371121 122310 90133793
Completed suicide 296.60 9.34 1282 371062 143776 90112327
Febrile neutropenia 233.23 9.34 185 372159 158164 90097939
Coronary artery disease 230.44 9.34 459 371885 33164 90222939
Acute kidney injury 199.00 9.34 2102 370242 318285 89937818
Drug abuse 176.38 9.34 59 372285 82288 90173815
Neutropenia 169.28 9.34 425 371919 224479 90031624
Myelosuppression 167.66 9.34 14 372330 53577 90202526
Pyrexia 133.73 9.34 1910 370434 658575 89597528
Arterial occlusive disease 129.43 9.34 204 372140 12242 90243861
Blood cholesterol increased 127.27 9.34 1361 370983 206651 90049452
Liver injury 126.20 9.34 1161 371183 169406 90086697
BRASH syndrome 124.24 9.34 84 372260 1795 90254308
Lip swelling 123.16 9.34 394 371950 38216 90217887
Hyperkalaemia 120.53 9.34 558 371786 64406 90191697
Acute myocardial infarction 120.49 9.34 366 371978 34524 90221579
Gangrene 120.24 9.34 201 372143 12675 90243428
Interstitial lung disease 117.93 9.34 85 372259 76320 90179783
Exposure during pregnancy 117.02 9.34 542 371802 237868 90018235
Type 2 diabetes mellitus 116.16 9.34 1312 371032 201932 90054171
Abortion spontaneous 115.29 9.34 39 372305 54017 90202086
Overdose 114.80 9.34 303 372041 157406 90098697
Swelling face 114.71 9.34 647 371697 80705 90175398
Injury 114.62 9.34 1278 371066 196071 90060032
Adjustment disorder with depressed mood 109.39 9.34 493 371851 56260 90199843
Contraindicated product administered 108.64 9.34 819 371525 319320 89936783
Psoriasis 108.42 9.34 1004 371340 146750 90109353
Blood glucose increased 103.25 9.34 708 371636 94538 90161565
Drug hypersensitivity 102.82 9.34 2562 369782 461047 89795056
Therapeutic product effect incomplete 101.66 9.34 430 371914 193466 90062637
Oedema 100.38 9.34 1261 371083 199034 90057069
Premature delivery 97.78 9.34 20 372324 38742 90217361
Hepatic function abnormal 97.67 9.34 34 372310 46254 90209849
Maternal exposure during pregnancy 97.35 9.34 977 371367 359086 89897017
Malignant neoplasm progression 94.26 9.34 185 372159 106685 90149418
Foetal exposure during pregnancy 93.42 9.34 30 372314 42945 90213158
Carotid artery thrombosis 93.13 9.34 148 372196 8944 90247159
Neurologic neglect syndrome 91.99 9.34 145 372199 8702 90247401
Hepatic cytolysis 91.62 9.34 10 372334 30906 90225197
Lupus vulgaris 89.54 9.34 395 371949 44664 90211439
Dislocation of vertebra 88.98 9.34 460 371884 55508 90200595
Oxygen saturation decreased 88.93 9.34 193 372151 107290 90148813
Lactic acidosis 88.17 9.34 426 371918 50037 90206066
Adjustment disorder 88.02 9.34 149 372195 9493 90246610
Hepatitis 87.24 9.34 97 372247 70642 90185461
Pancreatitis 86.63 9.34 537 371807 69289 90186814
Erythema 86.28 9.34 569 371775 228677 90027426
Chest pain 84.92 9.34 1812 370532 317833 89938270
Hypotensive transfusion reaction 84.83 9.34 23 372321 29 90256074
Labile blood pressure 84.54 9.34 67 372277 1843 90254260
Red blood cell sedimentation rate abnormal 82.60 9.34 4 372340 24200 90231903
Angina pectoris 82.19 9.34 349 371995 38811 90217292
Hepatotoxicity 80.39 9.34 44 372300 45798 90210305
Ulcer haemorrhage 79.80 9.34 264 372080 26057 90230046
Onychomycosis 77.93 9.34 28 372316 37348 90218755
Cytomegalovirus infection 77.84 9.34 9 372335 26593 90229510
Amnesia 77.42 9.34 733 371611 107772 90148331
Agranulocytosis 76.85 9.34 24 372320 34978 90221125
C-reactive protein increased 75.64 9.34 436 371908 180953 90075150
Memory impairment 75.11 9.34 1183 371161 196061 90060042
Back disorder 74.98 9.34 254 372090 25377 90230726
Swollen joint count increased 72.39 9.34 737 371607 110469 90145634
Mucosal inflammation 72.18 9.34 78 372266 57547 90198556
Skin haemorrhage 71.70 9.34 222 372122 21158 90234945
Cytokine release syndrome 71.47 9.34 14 372330 27959 90228144
Dehydration 71.32 9.34 1159 371185 193288 90062815
Coronary arterial stent insertion 70.70 9.34 72 372272 2768 90253335
Psoriatic arthropathy 70.49 9.34 1324 371020 227011 90029092
Thrombocytopenia 69.80 9.34 536 371808 208189 90047914
Coeliac disease 69.66 9.34 49 372295 44561 90211542
Suspected suicide 69.66 9.34 134 372210 9434 90246669
X-ray abnormal 69.22 9.34 369 371975 45055 90211048
Blood pressure diastolic abnormal 68.78 9.34 3 372341 19878 90236225
Sopor 68.11 9.34 10 372334 24634 90231469
Hypovolaemia 67.06 9.34 154 372190 12277 90243826
Renal failure 66.98 9.34 828 371516 130179 90125924
Subcutaneous drug absorption impaired 66.77 9.34 162 372182 13383 90242720
Coronary artery bypass 66.73 9.34 64 372280 2285 90253818
Deep vein thrombosis postoperative 66.16 9.34 508 371836 70301 90185802
Blood pressure systolic abnormal 64.05 9.34 4 372340 19474 90236629
Personality disorder 63.67 9.34 151 372193 12293 90243810
Infusion related reaction 63.37 9.34 1269 371075 415511 89840592
Decreased appetite 63.28 9.34 2009 370335 374531 89881572
Finger deformity 63.09 9.34 28 372316 32869 90223234
Sedation 62.82 9.34 63 372281 48108 90207995
Onychomadesis 62.49 9.34 58 372286 45940 90210163
General symptom 62.48 9.34 166 372178 14502 90241601
Depressed level of consciousness 62.46 9.34 128 372216 72656 90183447
Fibromyalgia 61.59 9.34 1190 371154 205079 90051024
Drug intolerance 61.58 9.34 1385 370959 446206 89809897
Food allergy 60.54 9.34 15 372329 25463 90230640
Rash vesicular 60.14 9.34 188 372156 18009 90238094
Intentional self-injury 59.44 9.34 23 372321 29311 90226792
Premature baby 59.13 9.34 15 372329 25062 90231041
Coma 58.78 9.34 132 372212 72500 90183603
Leukopenia 58.72 9.34 214 372130 100496 90155607
Drug resistance 58.27 9.34 26 372318 30423 90225680
Pneumocystis jirovecii pneumonia 56.98 9.34 10 372334 21606 90234497
Autoimmune disorder 56.52 9.34 522 371822 76222 90179881
Foetal death 55.92 9.34 9 372335 20714 90235389
Altered state of consciousness 55.68 9.34 30 372314 31502 90224601
Asthenia 55.55 9.34 2703 369641 531048 89725055
Dizziness 55.36 9.34 2955 369389 586329 89669774
Neutrophil count decreased 54.68 9.34 134 372210 71398 90184705
Hemiplegia 54.37 9.34 168 372176 15992 90240111
Retinitis 54.29 9.34 306 372038 38152 90217951
Suicide attempt 53.98 9.34 146 372198 75253 90180850
Therapy partial responder 52.34 9.34 13 372331 22030 90234073
Alanine aminotransferase increased 52.29 9.34 279 372065 118059 90138044
Affect lability 51.95 9.34 178 372166 17885 90238218
Sinus disorder 51.92 9.34 279 372065 34168 90221935
Rheumatoid nodule 51.71 9.34 10 372334 20156 90235947
Peripheral venous disease 51.69 9.34 550 371794 83371 90172732
Skin exfoliation 51.57 9.34 465 371879 67448 90188655
Anxiety 51.55 9.34 1651 370693 308121 89947982
Delirium 51.38 9.34 655 371689 103704 90152399
Pancytopenia 51.24 9.34 287 372057 119976 90136127
Abdominal pain upper 50.75 9.34 1755 370589 330919 89925184
Immunodeficiency 50.39 9.34 62 372282 43172 90212931
Liver function test increased 50.34 9.34 179 372165 84676 90171427
Disease progression 50.11 9.34 407 371937 156208 90099895
Diarrhoea 50.05 9.34 4493 367851 934697 89321406
Female genital tract fistula 49.97 9.34 7 372337 17861 90238242
Breast cancer stage II 49.78 9.34 281 372063 35053 90221050
Exostosis 49.53 9.34 381 371963 52753 90203350
Angina unstable 49.52 9.34 98 372246 7045 90249058
Mental status changes 48.92 9.34 333 372011 44346 90211757
Sedation complication 48.91 9.34 6 372338 16938 90239165
Blood pressure systolic increased 48.89 9.34 104 372240 58241 90197862
Rheumatic fever 48.31 9.34 891 371453 152230 90103873
Hypercholesterolaemia 48.30 9.34 630 371714 100262 90155841
Prescribed overdose 48.17 9.34 613 371731 97012 90159091
Coordination abnormal 47.69 9.34 194 372150 21162 90234941
Sensory loss 47.58 9.34 173 372171 17902 90238201
Gait disturbance 47.22 9.34 1403 370941 259093 89997010
Drug reaction with eosinophilia and systemic symptoms 47.06 9.34 64 372280 42694 90213409
Septic shock 47.00 9.34 182 372162 83978 90172125
Rheumatoid factor positive 46.47 9.34 976 371368 170674 90085429
Hypoaesthesia 46.28 9.34 1651 370693 312559 89943544
Walking aid user 45.89 9.34 276 372068 35230 90220873
Pustular psoriasis 45.84 9.34 174 372170 18382 90237721
Osteoarthritis 45.78 9.34 1090 371254 194640 90061463
Lower limb fracture 44.61 9.34 540 371804 84473 90171630
Hypoaldosteronism 44.42 9.34 24 372320 335 90255768
Grip strength decreased 44.29 9.34 578 371766 91998 90164105
Adverse drug reaction 44.04 9.34 699 371645 116002 90140101
Spinal stenosis 43.55 9.34 164 372180 17260 90238843
Intestinal ischaemia 43.52 9.34 106 372238 8777 90247326
Blood pressure fluctuation 43.44 9.34 94 372250 52319 90203784
Muscle spasms 43.35 9.34 1348 370996 250535 90005568
Status epilepticus 43.16 9.34 12 372332 18862 90237241
Product label confusion 42.96 9.34 20 372324 22830 90233273
Grip strength 42.89 9.34 106 372238 8859 90247244
Product use issue 42.78 9.34 1030 371314 328889 89927214
Macular degeneration 42.64 9.34 56 372288 37914 90218189
Proctitis 42.62 9.34 6 372338 15253 90240850
Blood pressure increased 42.45 9.34 1086 371258 196131 90059972
Oral candidiasis 42.21 9.34 50 372294 35405 90220698
Gastrointestinal haemorrhage 42.15 9.34 561 371783 89687 90166416
Adverse reaction 42.12 9.34 36 372308 29676 90226427
Thrombotic microangiopathy 42.12 9.34 7 372337 15736 90240367
Panniculitis 42.03 9.34 5 372339 14453 90241650
Lymphopenia 41.54 9.34 21 372323 22860 90233243
Chronic sinusitis 41.51 9.34 23 372321 23779 90232324
Blood pressure inadequately controlled 41.48 9.34 84 372260 6140 90249963
Wound infection 41.17 9.34 640 371704 105762 90150341
Distributive shock 41.10 9.34 60 372284 3364 90252739
Dysarthria 40.83 9.34 372 371972 54110 90201993
Motor dysfunction 40.83 9.34 172 372172 19058 90237045
Rash maculo-papular 40.45 9.34 66 372278 40867 90215236
Chronic kidney disease 40.35 9.34 348 371996 49843 90206260
Device expulsion 40.34 9.34 66 372278 40820 90215283
Myositis 40.23 9.34 201 372143 23927 90232176
Body temperature decreased 40.13 9.34 24 372320 23792 90232311
Temperature regulation disorder 40.10 9.34 6 372338 14573 90241530
Bronchiectasis 39.79 9.34 21 372323 22309 90233794
Eating disorder 39.38 9.34 223 372121 27850 90228253
Adverse event 39.06 9.34 689 371655 116729 90139374
Product complaint 38.80 9.34 133 372211 13367 90242736
Pain 38.76 9.34 3546 368798 992795 89263308
Eosinophilia 38.73 9.34 36 372308 28497 90227606
Poisoning deliberate 38.61 9.34 10 372334 16476 90239627
Arteriosclerosis 38.55 9.34 115 372229 10738 90245365
Product dose omission issue 38.46 9.34 1514 370830 290173 89965930
Dry mouth 38.29 9.34 1009 371335 183050 90073053
Lip dry 38.21 9.34 605 371739 100350 90155753
Cognitive disorder 38.18 9.34 151 372193 69256 90186847
Sinus congestion 37.91 9.34 217 372127 27207 90228896
Pneumonitis 37.62 9.34 78 372266 44092 90212011
Somatic delusion 37.18 9.34 26 372318 588 90255515
Hemiparesis 37.16 9.34 241 372103 31578 90224525
Atrioventricular block second degree 36.99 9.34 66 372278 4386 90251717
Caesarean section 36.92 9.34 15 372329 18562 90237541
Glycosylated haemoglobin increased 36.05 9.34 143 372201 15419 90240684
Neurotoxicity 35.66 9.34 22 372322 21445 90234658
Bronchopulmonary aspergillosis 35.59 9.34 3 372341 11395 90244708
Body temperature increased 35.57 9.34 82 372262 44628 90211475
Road traffic accident 35.25 9.34 630 371714 106996 90149107
Haemophagocytic lymphohistiocytosis 35.03 9.34 10 372334 15449 90240654
Haematotoxicity 34.84 9.34 5 372339 12530 90243573
Blood sodium decreased 34.64 9.34 213 372131 27400 90228703
Injection site reaction 34.38 9.34 229 372115 91851 90164252
Toxic skin eruption 34.30 9.34 11 372333 15763 90240340
Sneezing 34.13 9.34 225 372119 29644 90226459
Progressive multifocal leukoencephalopathy 33.90 9.34 11 372333 15644 90240459
Tenosynovitis 33.80 9.34 9 372335 14558 90241545
Porphyria acute 33.77 9.34 155 372189 17820 90238283
Foetal methotrexate syndrome 33.57 9.34 14 372330 104 90255999
Laboratory test abnormal 33.54 9.34 290 372054 41564 90214539
Drug eruption 33.24 9.34 59 372285 35348 90220755
Ischaemic cardiomyopathy 33.14 9.34 47 372297 2566 90253537
Arthralgia 33 9.34 2752 369592 775770 89480333
Joint range of motion decreased 32.81 9.34 759 371585 134884 90121219
Depression 32.62 9.34 1529 370815 299072 89957031
Product quality issue 32.56 9.34 482 371862 78843 90177260
Aphasia 32.43 9.34 293 372051 42519 90213584
Rotator cuff repair 32.40 9.34 45 372299 2409 90253694
Gamma-glutamyltransferase increased 32.34 9.34 67 372277 37885 90218218
Renal injury 32.18 9.34 104 372240 10139 90245964
Sciatica 31.99 9.34 590 371754 100792 90155311
Night sweats 31.92 9.34 723 371621 128043 90128060
Dysphagia 31.89 9.34 643 371701 111635 90144468
Cataract 31.56 9.34 443 371901 71649 90184454
Schizophrenia 31.39 9.34 11 372333 14903 90241200
Treatment failure 31.09 9.34 981 371363 302947 89953156
COVID-19 31.02 9.34 497 371847 168346 90087757
Cholestasis 31.00 9.34 64 372280 36235 90219868
Neck pain 30.83 9.34 309 372035 113654 90142449
Disability 29.92 9.34 277 372067 40468 90215635
Pancreatitis acute 29.77 9.34 230 372114 31885 90224218
Aphthous ulcer 29.72 9.34 17 372327 17270 90238833
Hepatic ischaemia 29.42 9.34 25 372319 760 90255343
Blood parathyroid hormone decreased 29.40 9.34 7 372337 12209 90243894
Anti-cyclic citrullinated peptide antibody 29.28 9.34 202 372142 27019 90229084
Pulseless electrical activity 29.26 9.34 92 372252 8840 90247263
Polyneuropathy 29.21 9.34 22 372322 19319 90236784
Bone marrow failure 29.08 9.34 55 372289 32166 90223937
Metastases to liver 28.89 9.34 46 372298 28761 90227342
Rash erythematous 28.47 9.34 154 372190 64950 90191153
Renal tubular acidosis 28.42 9.34 41 372303 2274 90253829
Cardiac failure 28.34 9.34 300 372044 109196 90146907
Abortion induced 28.25 9.34 7 372337 11881 90244222
Low birth weight baby 28.21 9.34 3 372341 9464 90246639
Pulmonary fibrosis 28.03 9.34 608 371736 106895 90149208
Muscle rigidity 27.72 9.34 12 372332 14297 90241806
Respiratory tract infection 27.38 9.34 137 372207 58941 90197162
Inappropriate schedule of product administration 27.32 9.34 442 371902 149491 90106612
Poor venous access 27.27 9.34 24 372320 19503 90236600
Extrapyramidal disorder 26.67 9.34 17 372327 16286 90239817
Creatinine renal clearance decreased 26.67 9.34 23 372321 18876 90237227
Colitis ischaemic 26.66 9.34 111 372233 12235 90243868
Shock 26.62 9.34 206 372138 28572 90227531
Oropharyngeal pain 26.52 9.34 324 372020 114863 90141240
International normalised ratio increased 26.34 9.34 304 372040 47012 90209091
C-reactive protein 26.01 9.34 219 372125 31148 90224955
Lupus-like syndrome 25.94 9.34 311 372033 48535 90207568
Procedural pain 25.88 9.34 62 372282 33298 90222805
Confusional state 25.86 9.34 1881 370463 384324 89871779
Blood pressure diastolic decreased 25.82 9.34 44 372300 26782 90229321
Jaundice cholestatic 25.71 9.34 5 372339 10038 90246065
Transient ischaemic attack 25.67 9.34 281 372063 42895 90213208
Dystonia 25.57 9.34 19 372325 16800 90239303
Encephalomalacia 25.46 9.34 20 372324 543 90255560
Anaemia 25.44 9.34 1187 371157 351615 89904488
Blood glucose decreased 25.28 9.34 174 372170 23255 90232848
Hyperlipidaemia 25.21 9.34 171 372173 22745 90233358
Myocardial ischaemia 25.13 9.34 118 372226 13696 90242407
Device difficult to use 25.13 9.34 21 372323 17504 90238599
Therapeutic product effect decreased 25.09 9.34 910 371434 276661 89979442
Device dislocation 24.83 9.34 58 372286 31424 90224679
Hepatocellular injury 24.78 9.34 51 372293 28907 90227196
Productive cough 24.76 9.34 200 372144 76863 90179240
Epstein-Barr virus infection 24.75 9.34 6 372338 10338 90245765
Respiratory tract congestion 24.69 9.34 195 372149 27215 90228888
Systemic lupus erythematosus 24.64 9.34 1225 371119 360671 89895432
Mouth ulceration 24.60 9.34 83 372261 39891 90216212
Neutropenic sepsis 24.46 9.34 23 372321 18107 90237996
Coronary artery occlusion 24.34 9.34 84 372260 8470 90247633
Laryngitis 24.32 9.34 317 372027 50436 90205667
Electrocardiogram QT prolonged 24.23 9.34 186 372158 72270 90183833
Drug use disorder 23.97 9.34 3 372341 8340 90247763
Nausea 23.95 9.34 5034 367310 1105282 89150821
Vision blurred 23.91 9.34 608 371736 109685 90146418
Hypertension 23.82 9.34 2186 370158 455346 89800757
Sight disability 23.80 9.34 12 372332 144 90255959
Drug dispensed to wrong patient 23.62 9.34 16 372328 343 90255760
Aspartate aminotransferase increased 23.52 9.34 290 372054 102647 90153456
Tongue oedema 23.51 9.34 62 372282 5392 90250711
Synostosis 23.48 9.34 9 372335 52 90256051
Herpes zoster 23.42 9.34 262 372082 94382 90161721
Oedema mouth 23.29 9.34 38 372306 2348 90253755
Rheumatoid arthritis 23.24 9.34 1760 370584 360854 89895249
Breast cancer stage III 23.11 9.34 481 371863 83966 90172137
Immune thrombocytopenia 23.06 9.34 13 372331 13313 90242790
Infection 23.06 9.34 1234 371110 360860 89895243
Pneumonia 23.01 9.34 2283 370061 635776 89620327
Atrioventricular block first degree 22.86 9.34 82 372262 8429 90247674
Ischaemic hepatitis 22.69 9.34 41 372303 2752 90253351
Muscle relaxant therapy 22.63 9.34 12 372332 161 90255942
Vaginal discharge 22.59 9.34 28 372316 19436 90236667
Thermohypoaesthesia 22.57 9.34 11 372333 122 90255981
Constipation 22.55 9.34 932 371412 279463 89976640
Blister 22.54 9.34 1272 371072 253726 90002377
Radiculopathy 22.13 9.34 26 372318 18479 90237624
Lymphocyte count decreased 22.10 9.34 72 372272 34978 90221125
Tuberculosis 22.07 9.34 12 372332 12537 90243566
Nodal rhythm 22.03 9.34 32 372312 1786 90254317
Hypotension 21.97 9.34 1586 370758 323811 89932292
Hepatorenal syndrome 21.89 9.34 34 372310 2014 90254089
Multiple-drug resistance 21.85 9.34 3 372341 7773 90248330
Abnormal dreams 21.84 9.34 98 372246 11159 90244944
Obesity 21.82 9.34 578 371766 104929 90151174
Blood loss anaemia 21.76 9.34 91 372253 10049 90246054
Cardiomyopathy 21.76 9.34 150 372194 20056 90236047
Oedema peripheral 21.73 9.34 1281 371063 256634 89999469
Hypocholesterolaemia 21.66 9.34 67 372277 6382 90249721
Musculoskeletal pain 21.65 9.34 885 371459 170366 90085737
Acute myeloid leukaemia 21.62 9.34 32 372312 20608 90235495
Atrial fibrillation 21.39 9.34 709 371635 132902 90123201
Sinus arrhythmia 21.31 9.34 28 372316 1421 90254682
Infusion site pain 21.26 9.34 30 372314 19708 90236395
Cardiac disorder 21.20 9.34 340 372004 56532 90199571
Blood potassium increased 21.16 9.34 152 372192 20597 90235506
Lymphomatoid papulosis 21.11 9.34 11 372333 142 90255961
Graft versus host disease 20.96 9.34 4 372340 8140 90247963
Respiratory depression 20.73 9.34 20 372324 15555 90240548
Diffuse large B-cell lymphoma 20.72 9.34 5 372339 8640 90247463
Eye injury 20.69 9.34 95 372249 10925 90245178
Essential hypertension 20.64 9.34 65 372279 6250 90249853
Hypogammaglobulinaemia 20.60 9.34 9 372335 10665 90245438
Nodular rash 20.56 9.34 12 372332 196 90255907
Acne 20.55 9.34 55 372289 28452 90227651
Wheezing 20.53 9.34 1185 371159 236895 90019208
Electrocardiogram T wave peaked 20.42 9.34 13 372331 250 90255853
Oral herpes 20.36 9.34 70 372274 33454 90222649
Vascular stent stenosis 20.31 9.34 19 372325 657 90255446
Blood lactate dehydrogenase increased 20.27 9.34 48 372296 25884 90230219
Muscular weakness 20.27 9.34 1041 371303 205625 90050478
Candida infection 20.09 9.34 72 372272 33985 90222118
Dilatation atrial 19.95 9.34 32 372312 1949 90254154
Transplant rejection 19.94 9.34 14 372330 12744 90243359
Gastrointestinal toxicity 19.89 9.34 7 372337 9460 90246643
Rash 19.80 9.34 2919 369425 793181 89462922
Duodenal ulcer perforation 19.58 9.34 1104 371240 220184 90035919
Uveitis 19.39 9.34 22 372322 15881 90240222
Overlap syndrome 19.36 9.34 78 372266 8470 90247633
Accelerated hypertension 19.35 9.34 16 372328 468 90255635
Infective pulmonary exacerbation of cystic fibrosis 19.32 9.34 9 372335 10270 90245833
Premature labour 19.21 9.34 16 372328 13360 90242743
Nephrogenic systemic fibrosis 19.05 9.34 48 372296 4060 90252043
Factor VII deficiency 19.00 9.34 8 372336 61 90256042
Pulmonary toxicity 18.90 9.34 12 372332 11519 90244584
Vascular device infection 18.83 9.34 13 372331 11939 90244164
Pre-eclampsia 18.80 9.34 11 372333 11037 90245066
Fracture 18.79 9.34 39 372305 22037 90234066
Palmar-plantar erythrodysaesthesia syndrome 18.78 9.34 56 372288 27967 90228136
Diabetic neuropathy 18.71 9.34 51 372293 4523 90251580
Blood test abnormal 18.70 9.34 36 372308 20916 90235187
Multiple organ dysfunction syndrome 18.60 9.34 185 372159 68151 90187952
Hepatic cirrhosis 18.54 9.34 364 371980 62889 90193214
Ankylosing spondylitis 18.51 9.34 16 372328 13117 90242986
Neoplasm progression 18.49 9.34 107 372237 44379 90211724
Pharyngitis 18.49 9.34 39 372305 21908 90234195
Synovitis 18.41 9.34 1138 371206 328614 89927489
Shock haemorrhagic 18.40 9.34 14 372330 12231 90243872
Neuroleptic malignant syndrome 18.28 9.34 21 372323 15075 90241028
Nasal polyps 18.28 9.34 11 372333 10869 90245234
Anhedonia 18.20 9.34 94 372250 11337 90244766
Hypertensive urgency 18.19 9.34 18 372326 668 90255435
Deformity 18.18 9.34 14 372330 12156 90243947
Second primary malignancy 18.14 9.34 10 372334 10368 90245735
Migraine 18.06 9.34 956 371388 189436 90066667
Transaminases increased 17.96 9.34 85 372259 37107 90218996
Device adhesion issue 17.85 9.34 3 372341 6688 90249415
Acute generalised exanthematous pustulosis 17.78 9.34 18 372326 13685 90242418
Pharyngeal oedema 17.76 9.34 107 372237 13664 90242439
Pseudomonas infection 17.66 9.34 21 372323 14844 90241259
Adactyly 17.51 9.34 7 372337 46 90256057
Abdominal distension 17.38 9.34 406 371938 130195 90125908
Hyperbilirubinaemia 17.30 9.34 19 372325 13917 90242186
Swollen joint count 17.30 9.34 76 372268 8577 90247526
Maternal exposure timing unspecified 17.09 9.34 154 372190 22329 90233774
Ear infection 17.04 9.34 391 371953 69384 90186719
Knee arthroplasty 17.00 9.34 455 371889 82727 90173376
Allergic cough 16.90 9.34 22 372322 1106 90254997
Haematochezia 16.88 9.34 198 372146 70715 90185388
Back injury 16.88 9.34 117 372227 46505 90209598
Renal cell carcinoma 16.83 9.34 44 372300 3807 90252296
Alopecia 16.78 9.34 1779 370565 493292 89762811
Paraesthesia oral 16.70 9.34 70 372274 31589 90224514
Blood pressure diastolic increased 16.69 9.34 17 372327 12889 90243214
Metastases to central nervous system 16.67 9.34 29 372315 17513 90238590
Aplastic anaemia 16.57 9.34 18 372326 13251 90242852
Bone erosion 16.53 9.34 308 372036 52713 90203390
Toxic epidermal necrolysis 16.50 9.34 73 372271 32455 90223648
Foetal growth restriction 16.45 9.34 9 372335 9371 90246732
Electrocardiogram T wave abnormal 16.42 9.34 35 372309 2653 90253450
Mobility decreased 16.39 9.34 1219 371125 249515 90006588
Tachypnoea 16.22 9.34 40 372304 21269 90234834
Blood potassium decreased 16.20 9.34 281 372063 47446 90208657
Skin toxicity 16.09 9.34 4 372340 6775 90249328
Tachycardia 16.09 9.34 509 371835 157164 90098939
Hip arthroplasty 15.90 9.34 418 371926 75790 90180313
Adrenal insufficiency 15.89 9.34 66 372278 29855 90226248
Blood calcium decreased 15.76 9.34 67 372277 30115 90225988
Enterocolitis 15.76 9.34 12 372332 10478 90245625
Full blood count decreased 15.75 9.34 189 372155 29500 90226603
Seizure 15.75 9.34 492 371852 152137 90103966
Fluid intake reduced 15.71 9.34 45 372299 4107 90251996
Lichen planus 15.52 9.34 35 372309 2756 90253347
Demyelination 15.50 9.34 7 372337 8133 90247970
Stevens-Johnson syndrome 15.47 9.34 65 372279 29311 90226792
Laryngotracheal oedema 15.47 9.34 6 372338 36 90256067
Transcription medication error 15.46 9.34 11 372333 256 90255847
Bursitis 15.42 9.34 675 371669 130979 90125124
Brain oedema 15.40 9.34 30 372314 17355 90238748
Discomfort 15.37 9.34 1318 371026 273017 89983086
Influenza like illness 15.36 9.34 437 371907 80174 90175929
Cytomegalovirus viraemia 15.28 9.34 6 372338 7580 90248523
Dysphonia 15.25 9.34 353 371991 62731 90193372
Chills 15.23 9.34 419 371925 131562 90124541
Upper respiratory tract infection 15.16 9.34 406 371938 127912 90128191
Concomitant disease aggravated 15.09 9.34 15 372329 11503 90244600
Ventricular hypertrophy 15.08 9.34 39 372305 3352 90252751
Gait inability 15.03 9.34 741 371603 145715 90110388
Generalised tonic-clonic seizure 15.02 9.34 83 372261 34820 90221283
Joint effusion 15 9.34 37 372307 19673 90236430
Metastases to bone 14.99 9.34 54 372290 25451 90230652
Product coating issue 14.98 9.34 8 372336 109 90255994
Visceral oedema 14.94 9.34 5 372339 18 90256085
Pemphigoid 14.91 9.34 75 372269 8951 90247152
Skin infection 14.83 9.34 32 372312 17832 90238271
Fear 14.83 9.34 118 372226 16504 90239599
Peripheral vascular disorder 14.82 9.34 59 372285 6372 90249731
Gestational diabetes 14.78 9.34 13 372331 10569 90245534
Acute respiratory distress syndrome 14.78 9.34 64 372280 28622 90227481
Hypertrophic cardiomyopathy 14.77 9.34 30 372314 2198 90253905
Factor VIII inhibition 14.69 9.34 6 372338 42 90256061
Cough 14.65 9.34 1731 370613 367231 89888872
Nasal congestion 14.50 9.34 248 372096 83166 90172937
Inflammation 14.48 9.34 593 371751 177999 90078104
Eczema 14.44 9.34 143 372201 52727 90203376
Ovarian cyst 14.40 9.34 31 372313 17287 90238816
Urethral prolapse 14.36 9.34 4 372340 6 90256097
Application site nodule 14.36 9.34 4 372340 6 90256097
Pallor 14.29 9.34 82 372262 34083 90222020
Rhinitis 14.25 9.34 21 372323 13551 90242552
Device related infection 14.24 9.34 56 372288 25730 90230373
Vasoplegia syndrome 14.24 9.34 34 372310 2780 90253323
Secondary hypertension 14.21 9.34 11 372333 292 90255811
Syncope 14.20 9.34 674 371670 131989 90124114
Non-cardiac chest pain 14.18 9.34 60 372284 6661 90249442
Therapy cessation 14.17 9.34 219 372125 36142 90219961
Lacunar infarction 14.16 9.34 38 372306 3339 90252764
Lymphadenopathy 14.16 9.34 120 372224 45655 90210448
Hypergammaglobulinaemia 14.12 9.34 15 372329 606 90255497
Transient psychosis 14.12 9.34 6 372338 47 90256056
Mydriasis 14.10 9.34 25 372319 14987 90241116
Hyperthermia 14.08 9.34 13 372331 10322 90245781
Joint swelling 14.06 9.34 1832 370512 501468 89754635
Cerebral thrombosis 14.05 9.34 26 372318 1777 90254326
Vasculitis 14.04 9.34 47 372297 22646 90233457
Product substitution issue 14.02 9.34 124 372220 17884 90238219
Rhinitis allergic 13.99 9.34 30 372314 16755 90239348
Gastric ulcer helicobacter 13.98 9.34 4 372340 7 90256096
Haemodialysis 13.97 9.34 72 372272 8675 90247428
Vomiting 13.91 9.34 3542 368802 784751 89471352
Helicobacter infection 13.85 9.34 1097 371247 225753 90030350
Colitis 13.82 9.34 203 372141 69739 90186364
Premature rupture of membranes 13.75 9.34 3 372341 5555 90250548
Lung opacity 13.73 9.34 4 372340 6098 90250005
Multimorbidity 13.71 9.34 15 372329 627 90255476
Asphyxia 13.69 9.34 6 372338 7097 90249006
Paramnesia 13.63 9.34 4 372340 8 90256095
Throat irritation 13.60 9.34 131 372213 48564 90207539
Arthropathy 13.51 9.34 1308 371036 364934 89891169
Ischaemic neuropathy 13.50 9.34 3 372341 0 90256103
Blood electrolytes abnormal 13.48 9.34 20 372324 1138 90254965
Blood bilirubin increased 13.42 9.34 114 372230 43356 90212747
Incorrect product administration duration 13.39 9.34 38 372306 19284 90236819
Venoocclusive liver disease 13.35 9.34 4 372340 5989 90250114
Sepsis 13.34 9.34 603 371741 179211 90076892
Visual acuity reduced 13.29 9.34 151 372193 23259 90232844
Dysgeusia 13.29 9.34 296 372048 52264 90203839
Hyperammonaemia 13.25 9.34 5 372339 6470 90249633
Expired product administered 13.24 9.34 60 372284 6862 90249241
Drug-induced liver injury 13.09 9.34 277 372067 90041 90166062
Hypophagia 13.08 9.34 214 372130 35723 90220380
Disseminated intravascular coagulation 13.06 9.34 45 372299 21493 90234610
Palpitations 13.05 9.34 687 371657 136041 90120062
Blood urea increased 12.95 9.34 186 372158 30227 90225876
Encephalitis 12.94 9.34 16 372328 11118 90244985
Apparent death 12.79 9.34 20 372324 1192 90254911
Skin necrosis 12.74 9.34 32 372312 16909 90239194
Facial nerve disorder 12.69 9.34 14 372330 591 90255512
Ulcer 12.67 9.34 81 372263 32801 90223302
Heart rate increased 12.62 9.34 360 371984 112542 90143561
Diverticulum 12.50 9.34 89 372255 12024 90244079
Hereditary angioedema 12.50 9.34 12 372332 9353 90246750
Exercise tolerance increased 12.49 9.34 5 372339 33 90256070
Skin reaction 12.48 9.34 37 372307 18516 90237587
Drug dependence 12.48 9.34 70 372274 29257 90226846
Somnolence 12.47 9.34 717 371627 208367 90047736
Fear of injection 12.46 9.34 10 372334 8505 90247598
Erythema nodosum 12.43 9.34 4 372340 5720 90250383
Hypomania 12.34 9.34 11 372333 8886 90247217
Glomerulonephropathy 12.29 9.34 7 372337 109 90255994
Weight decreased 12.25 9.34 1760 370584 378150 89877953
Withdrawal hypertension 12.25 9.34 8 372336 161 90255942
Raynaud's phenomenon 12.19 9.34 19 372325 1129 90254974
Peripheral sensory neuropathy 12.17 9.34 12 372332 9238 90246865
Pneumonia viral 12.13 9.34 11 372333 8812 90247291
Anaphylactic shock 12.12 9.34 78 372266 31539 90224564
Gout 12.07 9.34 114 372230 16745 90239358
Depressed mood 12.04 9.34 140 372204 50082 90206021
Craniosynostosis 11.99 9.34 8 372336 167 90255936
Foreign body in reproductive tract 11.84 9.34 19 372325 1158 90254945
Fluid retention 11.77 9.34 458 371886 87633 90168470
Drug specific antibody present 11.72 9.34 4 372340 5510 90250593
Epilepsy 11.66 9.34 253 372091 81953 90174150
Erythema marginatum 11.62 9.34 4 372340 16 90256087
Rhinovirus infection 11.55 9.34 5 372339 5958 90250145
Carotid artery stenosis 11.55 9.34 48 372296 5286 90250817
Diabetic ketoacidosis 11.51 9.34 152 372192 24255 90231848
Hypertensive emergency 11.45 9.34 27 372317 2190 90253913
Autonomic failure syndrome 11.43 9.34 3 372341 3 90256100
Metastases to lymph nodes 11.41 9.34 19 372325 11670 90244433
Unresponsive to stimuli 11.38 9.34 220 372124 37901 90218202
Bone density decreased 11.38 9.34 35 372309 17310 90238793
Coronary artery surgery 11.36 9.34 5 372339 43 90256060
Vertigo 11.36 9.34 210 372134 69601 90186502
Ventricular septal defect 11.36 9.34 4 372340 5403 90250700
Body height decreased 11.31 9.34 86 372258 11863 90244240
Pathogen resistance 11.30 9.34 10 372334 8105 90247998
Congenital anomaly 11.26 9.34 6 372338 6341 90249762
Ear pruritus 11.26 9.34 7 372337 6796 90249307
Haemolysis 11.24 9.34 11 372333 8499 90247604
Conjunctivitis 11.22 9.34 64 372280 26642 90229461
Pulmonary embolism 11.12 9.34 432 371912 130388 90125715
Mixed liver injury 11.10 9.34 9 372335 7614 90248489
Forced expiratory volume decreased 11.05 9.34 5 372339 5803 90250300
Therapeutic response unexpected 11.05 9.34 138 372206 21742 90234361
Purpura 11.05 9.34 28 372316 14750 90241353
Contusion 10.97 9.34 1186 371158 250030 90006073
Immune-mediated enterocolitis 10.92 9.34 3 372341 4754 90251349
Cytopenia 10.89 9.34 36 372308 17413 90238690
Fear of eating 10.84 9.34 11 372333 421 90255682
Blood pressure abnormal 10.84 9.34 126 372218 19519 90236584
Pleural effusion 10.83 9.34 364 371980 111627 90144476
Left ventricular hypertrophy 10.83 9.34 52 372292 6092 90250011
Sputum discoloured 10.81 9.34 45 372299 20346 90235757
Chromatopsia 10.81 9.34 12 372332 510 90255593
Charles Bonnet syndrome 10.80 9.34 5 372339 49 90256054
Neutrophil count increased 10.78 9.34 42 372302 19348 90236755
Paraesthesia 10.69 9.34 1180 371164 249146 90006957
Heart rate decreased 10.67 9.34 155 372189 53350 90202753
Miosis 10.64 9.34 14 372330 9470 90246633
Nasal oedema 10.59 9.34 7 372337 6577 90249526
Nephrosclerosis 10.58 9.34 18 372326 1151 90254952
SUNCT syndrome 10.58 9.34 3 372341 5 90256098
Immunosuppression 10.56 9.34 21 372323 12056 90244047
Autoimmune haemolytic anaemia 10.52 9.34 5 372339 5640 90250463
Behaviour disorder 10.50 9.34 3 372341 4632 90251471
Visual impairment 10.49 9.34 654 371690 131711 90124392
Adenovirus infection 10.45 9.34 3 372341 4619 90251484
Myocarditis 10.44 9.34 26 372318 13780 90242323
Tonsillitis 10.43 9.34 8 372336 6961 90249142
Blood glucose fluctuation 10.43 9.34 45 372299 5038 90251065
Enthesopathy 10.43 9.34 14 372330 9390 90246713
Hepatic encephalopathy 10.37 9.34 26 372318 13746 90242357
COVID-19 pneumonia 10.35 9.34 39 372305 18138 90237965
Rales 10.34 9.34 32 372312 15795 90240308
Retroperitoneal oedema 10.31 9.34 4 372340 24 90256079
Feeling hot 10.28 9.34 405 371939 77603 90178500
Patent ductus arteriosus 10.27 9.34 3 372341 4566 90251537
Catheterisation cardiac 10.27 9.34 44 372300 4912 90251191
Maternal exposure before pregnancy 10.24 9.34 19 372325 11194 90244909
Umbilical hernia, obstructive 10.23 9.34 3 372341 6 90256097
Dizziness postural 10.22 9.34 68 372276 8985 90247118
Urine abnormality 10.22 9.34 10 372334 7727 90248376
Venous thrombosis 10.17 9.34 5 372339 5532 90250571
Cardioactive drug level increased 10.17 9.34 27 372317 2357 90253746
Osteonecrosis of jaw 10.17 9.34 107 372237 38996 90217107
Occult blood positive 10.16 9.34 38 372306 3985 90252118
Uraemic encephalopathy 10.15 9.34 9 372335 290 90255813
Chronic obstructive pulmonary disease 10.13 9.34 385 371959 73444 90182659
Emotional distress 10.09 9.34 209 372135 36453 90219650
Pulmonary mass 10.03 9.34 73 372271 28699 90227404
BK virus infection 10.03 9.34 3 372341 4495 90251608
Oesophageal candidiasis 10.02 9.34 8 372336 6821 90249282
Product solubility abnormal 9.99 9.34 16 372328 973 90255130
Enterococcal infection 9.97 9.34 16 372328 9975 90246128
Intracranial pressure increased 9.97 9.34 8 372336 6803 90249300
Bacterial sepsis 9.85 9.34 4 372340 4951 90251152
Multiple fractures 9.84 9.34 15 372329 9547 90246556
Tarsal tunnel syndrome 9.83 9.34 12 372332 565 90255538
Alanine aminotransferase abnormal 9.82 9.34 5 372339 5421 90250682
Respiratory distress 9.75 9.34 219 372125 38727 90217376
Choroidal effusion 9.72 9.34 14 372330 775 90255328
Oesophageal discomfort 9.72 9.34 9 372335 307 90255796
Refusal of treatment by patient 9.71 9.34 48 372296 5690 90250413
Drug clearance decreased 9.68 9.34 23 372321 1875 90254228
Drug dose omission by device 9.65 9.34 17 372327 10214 90245889
Macular fibrosis 9.64 9.34 10 372334 393 90255710
Small intestinal ulcer haemorrhage 9.63 9.34 5 372339 64 90256039
Eosinophil count increased 9.61 9.34 25 372319 13056 90243047
Torsade de pointes 9.58 9.34 100 372244 15082 90241021
Ventricular fibrillation 9.58 9.34 94 372250 13950 90242153
Disturbance in attention 9.56 9.34 136 372208 46973 90209130
Peritonitis 9.53 9.34 45 372299 19660 90236443
Hypoperfusion 9.51 9.34 22 372322 1762 90254341
Stridor 9.51 9.34 42 372302 4751 90251352
Neutrophilia 9.49 9.34 6 372338 5772 90250331
Lip oedema 9.47 9.34 41 372303 4598 90251505
Eye irritation 9.45 9.34 194 372150 33784 90222319
Osmolar gap increased 9.40 9.34 7 372337 175 90255928
Hypoglycaemic unconsciousness 9.39 9.34 14 372330 800 90255303
Cerebral atrophy 9.39 9.34 47 372297 5599 90250504
Wound haematoma 9.37 9.34 5 372339 68 90256035
Pseudomonal sepsis 9.35 9.34 3 372341 4299 90251804
Lung disorder 9.34 9.34 726 371618 149157 90106946

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Angioedema 12680.12 11.11 5600 220588 36877 42358270
Myocardial infarction 778.13 11.11 1902 224286 122107 42273040
Cardiac failure congestive 750.86 11.11 1502 224686 84100 42311047
Hyperkalaemia 686.80 11.11 1396 224792 79062 42316085
Off label use 650.80 11.11 1528 224660 636807 41758340
Completed suicide 627.72 11.11 1501 224687 94964 42300183
Lip swelling 536.51 11.11 581 225607 18472 42376675
Swollen tongue 475.34 11.11 575 225613 20656 42374491
Febrile neutropenia 395.16 11.11 249 225939 185454 42209693
Acute kidney injury 372.13 11.11 3265 222923 364072 42031075
Coronary artery disease 369.86 11.11 855 225333 52865 42342282
Cerebrovascular accident 306.08 11.11 1171 225017 95989 42299158
Swelling face 264.93 11.11 503 225685 27051 42368096
Hypotension 262.84 11.11 2295 223893 255336 42139811
Drug abuse 261.80 11.11 114 226074 104657 42290490
Pyrexia 237.80 11.11 1180 225008 392862 42002285
Neutropenia 234.79 11.11 438 225750 198993 42196154
General physical health deterioration 229.44 11.11 279 225909 150967 42244180
Acute myocardial infarction 207.42 11.11 730 225458 57435 42337712
Dizziness 192.90 11.11 2096 224092 247158 42147989
Interstitial lung disease 175.40 11.11 99 226089 78363 42316784
Drug ineffective 174.97 11.11 2329 223859 627868 41767279
Myelosuppression 165.36 11.11 13 226175 40448 42354699
Intestinal angioedema 162.12 11.11 57 226131 178 42394969
Suspected suicide 157.17 11.11 179 226009 6020 42389127
Foetal exposure during pregnancy 153.26 11.11 32 226156 47279 42347868
Product dose omission issue 148.23 11.11 1358 224830 153007 42242140
Condition aggravated 143.98 11.11 804 225384 259950 42135197
Coronary arterial stent insertion 142.03 11.11 138 226050 3847 42391300
Dehydration 136.51 11.11 1248 224940 140519 42254628
Pancreatitis 134.86 11.11 520 225668 42748 42352399
BRASH syndrome 129.34 11.11 94 226094 1731 42393416
Septic shock 127.74 11.11 180 226008 91492 42303655
Hepatic function abnormal 127.34 11.11 57 226131 51510 42343637
Psoriasis 125.35 11.11 551 225637 48053 42347094
Product use in unapproved indication 124.78 11.11 529 225659 183927 42211220
Drug hypersensitivity 122.41 11.11 925 225263 98464 42296683
Coronary artery bypass 117.07 11.11 136 226052 4674 42390473
Thrombocytopenia 110.29 11.11 577 225611 189702 42205445
Pharyngeal oedema 105.41 11.11 145 226043 5923 42389224
C-reactive protein increased 105.29 11.11 109 226079 63451 42331696
Drug resistance 101.43 11.11 28 226160 34220 42360927
Cholestasis 100.96 11.11 25 226163 32854 42362293
Intentional dose omission 97.65 11.11 173 226015 8813 42386334
Cytokine release syndrome 94.12 11.11 60 226128 44467 42350680
Hepatic cytolysis 93.73 11.11 15 226173 26829 42368318
Leukopenia 92.44 11.11 159 226029 74587 42320560
Treatment failure 88.18 11.11 122 226066 62502 42332645
Blood glucose increased 87.96 11.11 681 225507 73018 42322129
Cytomegalovirus infection 87.47 11.11 31 226157 32275 42362872
Chest pain 86.33 11.11 1125 225063 138405 42256742
Blood potassium increased 86.32 11.11 255 225933 18281 42376866
Hypotensive transfusion reaction 83.88 11.11 21 226167 6 42395141
Fatigue 83.06 11.11 2955 223233 432686 41962461
Bronchopulmonary aspergillosis 83.00 11.11 5 226183 19424 42375723
No adverse event 77.91 11.11 411 225777 38610 42356537
Intentional product use issue 77.31 11.11 166 226022 71667 42323480
Syncope 77.11 11.11 837 225351 98569 42296578
Altered state of consciousness 75.99 11.11 30 226158 29229 42365918
Disseminated intravascular coagulation 73.93 11.11 20 226168 24774 42370373
Anaphylactic reaction 73.87 11.11 433 225755 42310 42352837
Cough 72.90 11.11 1339 224849 176764 42218383
Pancytopenia 72.17 11.11 350 225838 117393 42277754
Neutrophil count decreased 70.38 11.11 144 226044 63271 42331876
Lactic acidosis 69.07 11.11 444 225744 44817 42350330
Mucosal inflammation 68.69 11.11 97 226091 49277 42345870
Mental status changes 67.91 11.11 419 225769 41696 42353451
Hepatocellular injury 67.11 11.11 21 226167 23657 42371490
Multiple organ dysfunction syndrome 66.32 11.11 277 225911 96758 42298389
Agranulocytosis 63.67 11.11 42 226146 30570 42364577
International normalised ratio increased 63.06 11.11 455 225733 47713 42347434
Renal injury 62.08 11.11 174 226014 12106 42383041
Renal tubular necrosis 61.66 11.11 226 225962 18128 42377019
Blood pressure inadequately controlled 61.45 11.11 76 226112 2792 42392355
Bronchiectasis 60.85 11.11 11 226177 18008 42377139
Therapy cessation 60.64 11.11 242 225946 20208 42374939
Injury 59.81 11.11 256 225932 22060 42373087
Synovitis 58.35 11.11 7 226181 15560 42379587
Hypovolaemia 58.32 11.11 163 226025 11322 42383825
Bone marrow failure 56.80 11.11 55 226133 33038 42362109
Distributive shock 54.86 11.11 67 226121 2429 42392718
Therapeutic product effect incomplete 54.59 11.11 193 225995 70746 42324401
Pneumocystis jirovecii pneumonia 54.50 11.11 33 226155 25148 42369999
Premature baby 53.48 11.11 28 226160 23125 42372022
Product use issue 53.12 11.11 218 225970 76533 42318614
Therapy partial responder 52.87 11.11 20 226168 20001 42375146
Device interaction 52.84 11.11 35 226153 551 42394596
Blood urea increased 52.70 11.11 326 225862 32467 42362680
Sepsis 52.57 11.11 743 225445 198591 42196556
Feeling abnormal 52.44 11.11 584 225604 69202 42325945
Oral allergy syndrome 51.92 11.11 14 226174 10 42395137
Dysphagia 51.69 11.11 602 225586 72117 42323030
Epilepsy 51.66 11.11 38 226150 26133 42369014
Drug intolerance 51.65 11.11 235 225953 80189 42314958
Lymphopenia 51.42 11.11 25 226163 21538 42373609
Disease progression 51.19 11.11 501 225687 143155 42251992
Coma 51.03 11.11 132 226056 53422 42341725
Cardiac disorder 50.72 11.11 438 225750 48494 42346653
Lung disorder 50.52 11.11 112 226076 47811 42347336
Hypertensive emergency 50.18 11.11 47 226141 1250 42393897
Angina unstable 50.01 11.11 154 226034 11294 42383853
Tongue oedema 48.56 11.11 73 226115 3237 42391910
Drug reaction with eosinophilia and systemic symptoms 48 11.11 94 226094 41981 42353166
Blood lactate dehydrogenase increased 47.55 11.11 41 226147 26040 42369107
Liver disorder 46.60 11.11 87 226101 39557 42355590
Toxic skin eruption 45.05 11.11 9 226179 13721 42381426
Aspergillus infection 44.96 11.11 14 226174 15823 42379324
Vascular graft 44.74 11.11 48 226140 1508 42393639
Renal failure 44.44 11.11 1037 225151 142689 42252458
Malignant neoplasm progression 44.31 11.11 365 225823 108035 42287112
Thrombotic microangiopathy 43.93 11.11 12 226176 14770 42380377
Drug ineffective for unapproved indication 43.81 11.11 114 226074 46049 42349098
Drug dependence 43.69 11.11 54 226134 29040 42366107
Lymphocyte count decreased 43.48 11.11 50 226138 27759 42367388
Vision blurred 43.40 11.11 456 225732 53243 42341904
Asthenia 43.27 11.11 1862 224326 278931 42116216
Pharyngeal swelling 42.84 11.11 70 226118 3337 42391810
Bradycardia 42.70 11.11 664 225524 84820 42310327
Product quality issue 42.54 11.11 198 225990 17684 42377463
Eosinophilia 42.50 11.11 68 226120 32831 42362316
Muscle spasms 42.47 11.11 667 225521 85377 42309770
Febrile bone marrow aplasia 42.36 11.11 3 226185 10178 42384969
Anhedonia 42.36 11.11 112 226076 7528 42387619
Pancreatitis necrotising 41.92 11.11 72 226116 3577 42391570
Respiratory symptom 41.61 11.11 5 226183 11101 42384046
Hypophagia 41.46 11.11 265 225923 26691 42368456
Gamma-glutamyltransferase increased 41.20 11.11 68 226120 32429 42362718
Fear 41.11 11.11 140 226048 10825 42384322
Aplastic anaemia 40.88 11.11 8 226180 12376 42382771
Sopor 40.60 11.11 10 226178 13192 42381955
Blood glucose decreased 40.35 11.11 166 226022 14053 42381094
Blood creatinine increased 40.17 11.11 813 225375 109190 42285957
Infection 39.84 11.11 391 225797 111677 42283470
Dysphonia 39.72 11.11 273 225915 28177 42366970
Myocardial ischaemia 39.59 11.11 193 225995 17569 42377578
Immune reconstitution inflammatory syndrome 39.44 11.11 4 226184 10139 42385008
Pancreatitis acute 39.38 11.11 309 225879 33255 42361892
Haemophagocytic lymphohistiocytosis 39.27 11.11 24 226164 18198 42376949
Low birth weight baby 38.51 11.11 4 226184 9951 42385196
Appendicitis 38.07 11.11 32 226156 20581 42374566
Colitis ulcerative 37.84 11.11 50 226138 26125 42369022
Venoocclusive liver disease 37.72 11.11 5 226183 10297 42384850
Ischaemic cardiomyopathy 37.58 11.11 97 226091 6425 42388722
COVID-19 36.96 11.11 415 225773 115533 42279614
Toxic epidermal necrolysis 36.76 11.11 53 226135 26697 42368450
Emotional distress 36.69 11.11 176 226012 15917 42379230
Anaemia 36.56 11.11 1171 225017 279107 42116040
Haematotoxicity 36.47 11.11 7 226181 10978 42384169
Electrocardiogram T wave peaked 36.05 11.11 31 226157 735 42394412
Lower respiratory tract infection 35.94 11.11 106 226082 41100 42354047
Hyperthermia 35.91 11.11 11 226177 12563 42382584
Myalgia 35.71 11.11 712 225476 95368 42299779
Orbital myositis 35.10 11.11 17 226171 140 42395007
Mouth swelling 35.06 11.11 51 226137 2195 42392952
Eosinophilic granulomatosis with polyangiitis 34.67 11.11 3 226185 8635 42386512
Cardiac failure 34.63 11.11 381 225807 106475 42288672
Dermatitis atopic 34.56 11.11 144 226044 12260 42382887
Post transplant lymphoproliferative disorder 34.43 11.11 4 226184 9116 42386031
Intentional self-injury 34.21 11.11 19 226169 15183 42379964
Graft versus host disease 33.98 11.11 13 226175 12912 42382235
Sedation 33.97 11.11 69 226119 30406 42364741
Hepatitis 33.80 11.11 58 226130 27242 42367905
Immune effector cell-associated neurotoxicity syndrome 33.68 11.11 5 226183 9456 42385691
Pneumonia 33.67 11.11 1865 224323 420284 41974863
Pelvic mass 33.55 11.11 19 226169 222 42394925
Hyperbilirubinaemia 33.47 11.11 36 226152 20599 42374548
Neurotoxicity 33.35 11.11 46 226142 23605 42371542
Ageusia 33.34 11.11 136 226052 11469 42383678
Glycosylated haemoglobin increased 32.90 11.11 146 226042 12778 42382369
Hyperphosphataemia 32.69 11.11 14 226174 12990 42382157
Diarrhoea 32.55 11.11 2853 223335 457996 41937151
Diabetic neuropathy 32.43 11.11 73 226115 4429 42390718
Fall 32.13 11.11 1537 224651 232983 42162164
Neuroleptic malignant syndrome 32.09 11.11 40 226148 21432 42373715
Hypoglycaemia 31.84 11.11 470 225718 59384 42335763
Asthma 31.69 11.11 197 225991 62117 42333030
Drug use disorder 31.44 11.11 8 226180 10325 42384822
Alanine aminotransferase increased 31.18 11.11 309 225879 88097 42307050
Pneumonitis 31.09 11.11 115 226073 41603 42353544
Infusion related reaction 31.04 11.11 192 225996 60614 42334533
Product substitution issue 30.63 11.11 130 226058 11160 42383987
Productive cough 30.58 11.11 155 226033 51412 42343735
Bacterial infection 30.34 11.11 64 226124 27815 42367332
Drooling 30.18 11.11 69 226119 4230 42390917
Unevaluable event 30.01 11.11 296 225892 33992 42361155
Pneumonia aspiration 30.00 11.11 150 226038 49928 42345219
Rheumatoid arthritis 29.70 11.11 120 226068 42320 42352827
Potassium wasting nephropathy 29.62 11.11 13 226175 83 42395064
Hypogammaglobulinaemia 29.57 11.11 13 226175 11878 42383269
Coronary artery occlusion 29.35 11.11 126 226062 10871 42384276
Status epilepticus 29.00 11.11 24 226164 15554 42379593
Loss of personal independence in daily activities 28.83 11.11 151 226037 49665 42345482
Orthostatic hypotension 28.78 11.11 268 225920 30302 42364845
Pulmonary alveolar haemorrhage 28.61 11.11 22 226166 14794 42380353
Miosis 28.57 11.11 18 226170 13428 42381719
Cystitis haemorrhagic 28.21 11.11 3 226185 7326 42387821
Multiple-drug resistance 28.18 11.11 3 226185 7319 42387828
Incorrect route of product administration 27.98 11.11 54 226134 24251 42370896
Product complaint 27.61 11.11 82 226106 5895 42389252
Nausea 27.44 11.11 2453 223735 394346 42000801
Oxygen saturation decreased 27.25 11.11 216 225972 64471 42330676
Vasculitis 26.73 11.11 35 226153 18359 42376788
Pseudomonas infection 26.70 11.11 27 226161 15896 42379251
Atrial fibrillation 26.69 11.11 948 225240 138645 42256502
Burning sensation 26.63 11.11 197 225991 20816 42374331
Ulnar nerve palsy 26.57 11.11 7 226181 4 42395143
Transplant rejection 26.47 11.11 20 226168 13568 42381579
Blood electrolytes abnormal 26.45 11.11 30 226158 1004 42394143
Drug-induced liver injury 26.29 11.11 109 226079 38164 42356983
Renal tubular acidosis 26.17 11.11 50 226138 2700 42392447
Anal abscess 26.06 11.11 5 226183 7845 42387302
Tumour lysis syndrome 25.93 11.11 49 226139 22182 42372965
Inappropriate schedule of product administration 25.76 11.11 356 225832 95546 42299601
Blood pressure increased 25.76 11.11 716 225472 101212 42293935
Transaminases increased 25.60 11.11 89 226099 32796 42362351
Hypoaesthesia oral 25.48 11.11 69 226119 4704 42390443
Stridor 25.43 11.11 50 226138 2758 42392389
Hypoaesthesia 25.36 11.11 526 225662 70937 42324210
Blood uric acid increased 25.35 11.11 27 226161 15520 42379627
Allergic cough 25.29 11.11 10 226178 47 42395100
Myasthenia gravis 25.24 11.11 29 226159 16108 42379039
Paraesthesia 25.19 11.11 538 225650 72921 42322226
Epstein-Barr virus infection 25.17 11.11 10 226178 9708 42385439
Frequent bowel movements 25.13 11.11 47 226141 21360 42373787
Akathisia 25.10 11.11 12 226176 10439 42384708
Pulmonary renal syndrome 25.05 11.11 16 226172 236 42394911
Rash 24.81 11.11 1747 224441 275207 42119940
Pathogen resistance 24.79 11.11 15 226173 11435 42383712
Polyneuropathy 24.64 11.11 38 226150 18623 42376524
Dyspnoea 24.59 11.11 2695 223493 439926 41955221
Laryngeal oedema 24.54 11.11 61 226127 3947 42391200
BK virus infection 24.52 11.11 8 226180 8776 42386371
Enterocolitis 24.46 11.11 11 226177 9918 42385229
Vitreous floaters 24.46 11.11 63 226125 4167 42390980
Encephalitis 24.43 11.11 9 226179 9149 42385998
Increased tendency to bruise 24.16 11.11 64 226124 4306 42390841
Maternal exposure during pregnancy 24.13 11.11 4 226184 6974 42388173
Somnolence 23.91 11.11 568 225620 140537 42254610
Similar reaction on previous exposure to drug 23.71 11.11 9 226179 37 42395110
Substance abuse 23.34 11.11 9 226179 8896 42386251
Aspartate aminotransferase increased 23.10 11.11 280 225908 76883 42318264
Oropharyngeal swelling 23.09 11.11 22 226166 598 42394549
Second primary malignancy 22.98 11.11 11 226177 9564 42385583
Pruritus 22.91 11.11 1223 224965 187548 42207599
Haematochezia 22.86 11.11 199 225989 58237 42336910
Haemorrhage intracranial 22.84 11.11 163 226025 17029 42378118
Neuritis 22.82 11.11 3 226185 6217 42388930
Mydriasis 22.76 11.11 9 226179 8761 42386386
Cytopenia 22.75 11.11 36 226152 17461 42377686
Blood urea abnormal 22.54 11.11 29 226159 1109 42394038
Accelerated hypertension 22.37 11.11 16 226172 287 42394860
Platelet count decreased 22.35 11.11 562 225626 138019 42257128
Pulmonary fibrosis 22.29 11.11 70 226118 26611 42368536
Labelled drug-drug interaction medication error 22.28 11.11 30 226158 15552 42379595
Burns second degree 22.22 11.11 3 226185 6093 42389054
Pancreatitis haemorrhagic 22.21 11.11 18 226170 392 42394755
Prostate cancer recurrent 22.09 11.11 28 226160 1055 42394092
Exposure during pregnancy 21.81 11.11 9 226179 8539 42386608
No reaction on previous exposure to drug 21.78 11.11 10 226178 72 42395075
Azotaemia 21.51 11.11 75 226113 5869 42389278
Electrocardiogram change 21.43 11.11 22 226166 656 42394491
Conjunctivitis allergic 21.33 11.11 3 226185 5908 42389239
Blood phosphorus increased 21.28 11.11 21 226167 12504 42382643
Progressive multifocal leukoencephalopathy 21.19 11.11 18 226170 11518 42383629
Blood sodium decreased 21.19 11.11 167 226021 17995 42377152
Extrapyramidal disorder 21.12 11.11 34 226154 16378 42378769
Eczema 21.05 11.11 101 226087 33985 42361162
Pemphigus 21 11.11 38 226150 1968 42393179
Lung opacity 20.97 11.11 3 226185 5834 42389313
Peripheral vascular disorder 20.92 11.11 69 226119 5248 42389899
Nodular rash 20.89 11.11 11 226177 110 42395037
Tuberculosis 20.81 11.11 14 226174 10085 42385062
Eosinophil count increased 20.76 11.11 16 226172 10747 42384400
Chronic kidney disease 20.63 11.11 359 225829 46882 42348265
Stent placement 20.59 11.11 69 226119 5291 42389856
Cytomegalovirus viraemia 20.57 11.11 15 226173 10362 42384785
Throat tightness 20.47 11.11 103 226085 9496 42385651
Behaviour disorder 20.45 11.11 6 226182 7048 42388099
Gallbladder oedema 20.22 11.11 14 226174 238 42394909
Eye swelling 20.10 11.11 120 226068 11800 42383347
Renal impairment neonatal 20.01 11.11 6 226182 9 42395138
Depressed level of consciousness 19.83 11.11 161 226027 47809 42347338
Suture rupture 19.81 11.11 18 226170 460 42394687
Hepatitis cholestatic 19.73 11.11 14 226174 9810 42385337
Diabetic foot infection 19.69 11.11 22 226166 724 42394423
Chronic graft versus host disease 19.66 11.11 4 226184 6021 42389126
Essential hypertension 19.64 11.11 54 226134 3714 42391433
Poisoning deliberate 19.63 11.11 15 226173 10119 42385028
Respiratory tract oedema 19.59 11.11 17 226171 408 42394739
Renal artery stenosis 19.48 11.11 40 226148 2277 42392870
Myelodysplastic syndrome 19.48 11.11 59 226129 22686 42372461
Generalised tonic-clonic seizure 19.47 11.11 73 226115 26306 42368841
Glomerulonephritis minimal lesion 19.44 11.11 21 226167 665 42394482
Anaphylactic shock 19.44 11.11 62 226126 23455 42371692
Paraesthesia oral 19.43 11.11 66 226122 5097 42390050
Product coating issue 19.42 11.11 7 226181 24 42395123
Colitis 19.39 11.11 156 226032 46416 42348731
Cholangitis 19.39 11.11 17 226171 10710 42384437
Posterior reversible encephalopathy syndrome 19.04 11.11 24 226164 12797 42382350
Hepatotoxicity 19.00 11.11 69 226119 25098 42370049
Shock 18.90 11.11 237 225951 28884 42366263
Seizure 18.88 11.11 491 225697 120070 42275077
Rash maculo-papular 18.84 11.11 119 226069 37384 42357763
Acute hepatic failure 18.74 11.11 39 226149 17034 42378113
Neutrophil count increased 18.72 11.11 49 226139 19755 42375392
Gastrointestinal haemorrhage 18.50 11.11 663 225525 97063 42298084
Intercepted product preparation error 18.50 11.11 8 226180 7381 42387766
Toe amputation 18.38 11.11 45 226143 2884 42392263
Drug interaction 18.31 11.11 1196 224992 265803 42129344
Carcinoid tumour of the small bowel 18.13 11.11 16 226172 393 42394754
Lymphoma 18.12 11.11 30 226158 14291 42380856
Respiratory tract infection 18.05 11.11 75 226113 26247 42368900
Vasoplegia syndrome 17.97 11.11 42 226146 2613 42392534
Psychomotor skills impaired 17.96 11.11 3 226185 5201 42389946
Delirium 17.92 11.11 185 226003 52334 42342813
Acquired acrodermatitis enteropathica 17.78 11.11 5 226183 5 42395142
Pollakiuria 17.66 11.11 190 225998 22315 42372832
Adenovirus infection 17.65 11.11 7 226181 6802 42388345
Speech disorder 17.63 11.11 234 225954 28887 42366260
Spur cell anaemia 17.61 11.11 8 226180 56 42395091
Dizziness postural 17.59 11.11 85 226103 7710 42387437
Hypopnoea 17.52 11.11 10 226178 7872 42387275
Depression 17.43 11.11 740 225448 110623 42284524
Inflammatory marker increased 17.42 11.11 7 226181 6749 42388398
Dysgeusia 17.22 11.11 266 225922 33923 42361224
Oedema mouth 17.21 11.11 28 226160 1330 42393817
Transient ischaemic attack 17.19 11.11 263 225925 33476 42361671
Pericarditis 17.16 11.11 28 226160 13416 42381731
Carcinoid tumour of the gastrointestinal tract 17.15 11.11 8 226180 60 42395087
Nephrogenic systemic fibrosis 17.10 11.11 49 226139 3452 42391695
Erythema 17.05 11.11 443 225745 108350 42286797
Klebsiella infection 17.05 11.11 21 226167 11311 42383836
Neuralgia 17.02 11.11 74 226114 25573 42369574
Benign gastrointestinal neoplasm 17.01 11.11 10 226178 126 42395021
Tachycardia 16.82 11.11 408 225780 100679 42294468
Acute myeloid leukaemia 16.81 11.11 61 226127 22195 42372952
Pain 16.77 11.11 1513 224675 243335 42151812
Dialysis 16.72 11.11 115 226073 11871 42383276
Neurological symptom 16.69 11.11 17 226171 9974 42385173
Complications of transplanted kidney 16.55 11.11 4 226184 5346 42389801
Intentional product misuse 16.54 11.11 230 225958 61670 42333477
Hepatitis acute 16.49 11.11 14 226174 8961 42386186
Escherichia infection 16.23 11.11 22 226166 11374 42383773
Neutropenic sepsis 16.21 11.11 38 226150 15908 42379239
Immune-mediated enterocolitis 16.15 11.11 5 226183 5672 42389475
Organising pneumonia 16.12 11.11 10 226178 7522 42387625
Ascites 16.08 11.11 208 225980 56470 42338677
Hypotonia 16.05 11.11 16 226172 9483 42385664
Blood glucose abnormal 15.98 11.11 77 226111 6976 42388171
Full blood count abnormal 15.95 11.11 93 226095 29783 42365364
Pneumonia fungal 15.93 11.11 15 226173 9131 42386016
Pneumatosis intestinalis 15.83 11.11 3 226185 4749 42390398
Tympanic membrane disorder 15.78 11.11 7 226181 46 42395101
Accidental overdose 15.76 11.11 87 226101 28243 42366904
Soft tissue disorder 15.73 11.11 21 226167 833 42394314
Postural orthostatic tachycardia syndrome 15.68 11.11 10 226178 147 42395000
Neoplasm progression 15.63 11.11 90 226098 28910 42366237
Graft versus host disease in gastrointestinal tract 15.61 11.11 4 226184 5139 42390008
Pain in extremity 15.61 11.11 962 225226 149642 42245505
Blood bilirubin increased 15.60 11.11 146 226042 42106 42353041
Contrast media reaction 15.51 11.11 24 226164 1092 42394055
Urine oxalate increased 15.46 11.11 5 226183 11 42395136
Non-cardiac chest pain 15.40 11.11 56 226132 4473 42390674
Drug level increased 15.39 11.11 79 226109 26121 42369026
Pulmonary tuberculosis 15.37 11.11 5 226183 5496 42389651
Papillitis 15.37 11.11 8 226180 78 42395069
Myxoedema coma 15.17 11.11 12 226176 252 42394895
Cholelithiasis 15.15 11.11 190 225998 23156 42371991
Anal fistula 15.13 11.11 7 226181 6206 42388941
Iron deficiency 15.11 11.11 22 226166 11039 42384108
Psychotic disorder 15.02 11.11 92 226096 29116 42366031
Gastric cancer 15.00 11.11 9 226179 6894 42388253
Skin tightness 15.00 11.11 35 226153 2175 42392972
Musculoskeletal stiffness 14.95 11.11 216 225972 57549 42337598
Rhabdomyolysis 14.93 11.11 530 225658 77489 42317658
Acute coronary syndrome 14.85 11.11 132 226056 14733 42380414
Carcinoid tumour of the stomach 14.84 11.11 7 226181 54 42395093
Prostate tenderness 14.84 11.11 7 226181 54 42395093
Liver abscess 14.83 11.11 4 226184 4966 42390181
Hyperammonaemia 14.79 11.11 12 226176 7854 42387293
Hepatic failure 14.79 11.11 130 226058 37970 42357177
Diverticulum 14.75 11.11 79 226109 7462 42387685
Musculoskeletal chest pain 14.75 11.11 106 226082 11098 42384049
Skin induration 14.73 11.11 32 226156 1895 42393252
Migraine 14.72 11.11 77 226111 25337 42369810
Glossodynia 14.69 11.11 52 226136 4100 42391047
Haemodialysis 14.64 11.11 99 226089 10161 42384986
Infective pulmonary exacerbation of cystic fibrosis 14.61 11.11 12 226176 7806 42387341
COVID-19 pneumonia 14.56 11.11 62 226126 21551 42373596
Candida infection 14.56 11.11 62 226126 21548 42373599
Penile swelling 14.54 11.11 22 226166 981 42394166
Hypothyroidism 14.52 11.11 105 226083 31979 42363168
Enterococcal infection 14.52 11.11 26 226162 12013 42383134
Cachexia 14.46 11.11 13 226175 8091 42387056
Albumin urine present 14.41 11.11 14 226174 390 42394757
Device related infection 14.40 11.11 57 226131 20222 42374925
Acute respiratory distress syndrome 14.38 11.11 97 226091 30011 42365136
Endometriosis male 14.37 11.11 5 226183 15 42395132
Diabetic retinopathy 14.36 11.11 33 226155 2030 42393117
Autoimmune disorder 14.34 11.11 37 226151 2450 42392697
Blood urine present 14.30 11.11 109 226079 11624 42383523
Therapy change 14.24 11.11 51 226137 4044 42391103
Withdrawal hypertension 14.20 11.11 11 226177 224 42394923
Graft versus host disease in skin 14.11 11.11 5 226183 5207 42389940
Systemic infection 14.08 11.11 5 226183 5200 42389947
Enlarged uvula 14.08 11.11 12 226176 281 42394866
Type 2 diabetes mellitus 14.05 11.11 155 226033 18316 42376831
Circulatory collapse 14.04 11.11 71 226117 23565 42371582
Hypoglycaemic unconsciousness 14.02 11.11 19 226169 765 42394382
Osteoporosis 13.99 11.11 37 226151 14869 42380278
Hypertransaminasaemia 13.98 11.11 17 226171 9210 42385937
Ventricular fibrillation 13.91 11.11 98 226090 30025 42365122
Lymphomatoid papulosis 13.91 11.11 11 226177 231 42394916
Pneumopericardium 13.90 11.11 9 226179 136 42395011
Product administered to patient of inappropriate age 13.90 11.11 4 226184 4757 42390390
Psychomotor hyperactivity 13.82 11.11 23 226165 10935 42384212
Vomiting projectile 13.81 11.11 19 226169 776 42394371
Food allergy 13.81 11.11 34 226154 2187 42392960
Activated partial thromboplastin time prolonged 13.80 11.11 41 226147 15862 42379285
Intestinal obstruction 13.73 11.11 86 226102 27072 42368075
Sleep attacks 13.68 11.11 9 226179 140 42395007
Epiglottic oedema 13.67 11.11 10 226178 186 42394961
Brain abscess 13.66 11.11 3 226185 4281 42390866
Skin hypertrophy 13.59 11.11 39 226149 2750 42392397
Device leakage 13.53 11.11 21 226167 10264 42384883
Erythema multiforme 13.48 11.11 20 226168 9957 42385190
Erectile dysfunction 13.39 11.11 196 225992 24717 42370430
Dystonia 13.38 11.11 30 226158 12760 42382387
Inflammation 13.35 11.11 115 226073 33732 42361415
Alcoholism 13.35 11.11 40 226148 2890 42392257
Weaning failure 13.33 11.11 11 226177 246 42394901
Blood pressure diastolic abnormal 13.30 11.11 8 226180 6120 42389027
Systemic lupus erythematosus 13.28 11.11 18 226170 9306 42385841
Alcoholic ketoacidosis 13.21 11.11 6 226182 42 42395105
Dilatation atrial 13.21 11.11 33 226155 2142 42393005
Pulmonary arterial hypertension 13.21 11.11 21 226167 10166 42384981
Blood pressure fluctuation 13.20 11.11 86 226102 26822 42368325
Haemolysis 13.17 11.11 19 226169 9570 42385577
Kidney transplant rejection 13.16 11.11 16 226172 8667 42386480
Ulcer 13.13 11.11 44 226144 16397 42378750
Hallucination, auditory 13.13 11.11 38 226150 14826 42380321
Encephalopathy 13.13 11.11 148 226040 41185 42353962
Acetabulum fracture 13.10 11.11 14 226174 438 42394709
Cognitive disorder 13.08 11.11 117 226071 34055 42361092
Pulmonary toxicity 13.06 11.11 16 226172 8639 42386508
Uveitis 13.06 11.11 18 226170 9240 42385907
Diabetes mellitus inadequate control 13.05 11.11 132 226056 15258 42379889
Hypoalbuminaemia 13.01 11.11 41 226147 15569 42379578
Asphyxia 12.98 11.11 15 226173 8311 42386836
Breath sounds abnormal 12.96 11.11 28 226160 12065 42383082
Adrenal insufficiency 12.93 11.11 54 226134 18870 42376277
Aggression 12.93 11.11 161 226027 44002 42351145
Urine flow decreased 12.85 11.11 25 226163 1368 42393779
Raynaud's phenomenon 12.82 11.11 11 226177 260 42394887
Bacteraemia 12.81 11.11 79 226109 24961 42370186
Adenocarcinoma pancreas 12.81 11.11 26 226162 1468 42393679
Back pain 12.78 11.11 895 225293 140881 42254266
Spinal synovial cyst 12.73 11.11 3 226185 0 42395147
Lipoedema 12.73 11.11 3 226185 0 42395147
Cerebral infarction 12.70 11.11 105 226083 31064 42364083
Fistula 12.61 11.11 14 226174 7898 42387249
Neutropenic colitis 12.60 11.11 4 226184 4466 42390681
Acute cutaneous lupus erythematosus 12.57 11.11 7 226181 79 42395068
Meniere's disease 12.54 11.11 6 226182 48 42395099
Hypersensitivity 12.49 11.11 486 225702 71884 42323263
Terminal state 12.40 11.11 4 226184 4419 42390728
Full blood count decreased 12.36 11.11 165 226023 20395 42374752
Drug dose omission by device 12.34 11.11 8 226180 5878 42389269
Endotracheal intubation complication 12.34 11.11 13 226175 400 42394747
Cataract nuclear 12.30 11.11 18 226170 779 42394368
Skin toxicity 12.30 11.11 10 226178 6539 42388608
Sinus disorder 12.29 11.11 79 226109 7971 42387176
Cytomegalovirus colitis 12.27 11.11 3 226185 3978 42391169
Memory impairment 12.18 11.11 351 225837 49871 42345276
Paradoxical drug reaction 12.07 11.11 5 226183 4733 42390414
Cardiac operation 11.99 11.11 45 226143 3650 42391497
Herpes simplex 11.93 11.11 12 226176 7083 42388064
Pleural effusion 11.91 11.11 409 225779 96757 42298390
Tenosynovitis 11.89 11.11 5 226183 4690 42390457
Oral candidiasis 11.89 11.11 38 226150 14367 42380780
Nodule 11.85 11.11 31 226157 12503 42382644
Aneurysm 11.85 11.11 31 226157 2070 42393077
Hypophosphataemia 11.83 11.11 64 226124 20881 42374266
Obstructive airways disorder 11.71 11.11 80 226108 24679 42370468
Macroglossia 11.67 11.11 14 226174 498 42394649
Therapy non-responder 11.64 11.11 206 225982 53153 42341994
Hypertensive heart disease 11.54 11.11 35 226153 2545 42392602
Occult blood positive 11.53 11.11 49 226139 4208 42390939
Uvulitis 11.50 11.11 4 226184 12 42395135
Hepatocellular carcinoma 11.49 11.11 16 226172 8178 42386969
Anaesthesia 11.48 11.11 6 226182 59 42395088
Retching 11.48 11.11 76 226112 7745 42387402
Systemic candida 11.47 11.11 7 226181 5312 42389835
Hypoventilation 11.46 11.11 3 226185 3799 42391348
Tunnel vision 11.41 11.11 15 226173 586 42394561
Unresponsive to stimuli 11.41 11.11 232 225956 31171 42363976
Neurological decompensation 11.40 11.11 3 226185 3786 42391361
Stomatitis 11.40 11.11 193 225995 50136 42345011
Road traffic accident 11.38 11.11 153 226035 18940 42376207
Bronchospasm 11.34 11.11 33 226155 12852 42382295
Transfusion-related circulatory overload 11.34 11.11 17 226171 752 42394395
Product residue present 11.30 11.11 37 226151 2804 42392343
Angina pectoris 11.29 11.11 241 225947 32655 42362492
Abdominal distension 11.26 11.11 292 225896 71443 42323704
Diabetic autonomic neuropathy 11.26 11.11 4 226184 13 42395134
Sinus node dysfunction 11.24 11.11 53 226135 4759 42390388
Hypertriglyceridaemia 11.22 11.11 23 226165 10103 42385044
Apathy 11.21 11.11 17 226171 8389 42386758
Blood alkaline phosphatase increased 11.19 11.11 119 226069 33478 42361669

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Angioedema 13053.78 9.89 7018 475817 91482 110014982
Myocardial infarction 1395.38 9.89 2781 480054 189302 109917162
Cardiac failure congestive 1322.19 9.89 2368 480467 148632 109957832
Completed suicide 1001.50 9.89 2816 480019 239565 109866899
Intestinal angioedema 946.09 9.89 300 482535 797 110105667
Hyperkalaemia 844.01 9.89 1845 480990 133951 109972513
Swollen tongue 805.71 9.89 1148 481687 59214 110047250
Off label use 798.30 9.89 3610 479225 1496575 108609889
Acute kidney injury 702.25 9.89 4962 477873 630468 109475996
Cerebrovascular accident 696.94 9.89 2053 480782 179231 109927233
Coronary artery disease 694.41 9.89 1176 481659 70514 110035950
Lip swelling 563.69 9.89 885 481950 49782 110056682
Febrile neutropenia 540.92 9.89 359 482476 316408 109790056
Drug ineffective 491.12 9.89 4268 478567 1516272 108590192
Drug abuse 397.22 9.89 139 482696 177272 109929192
Acute myocardial infarction 379.01 9.89 1007 481828 82770 110023694
Neutropenia 344.99 9.89 697 482138 373923 109732541
Myelosuppression 314.22 9.89 26 482809 94314 110012150
Swelling face 307.54 9.89 995 481840 91326 110015138
Pyrexia 287.51 9.89 2524 480311 895741 109210723
BRASH syndrome 264.31 9.89 178 482657 3545 110102919
Hypotension 230.89 9.89 3386 479449 520463 109586001
Suspected suicide 225.09 9.89 304 482531 14895 110091569
Interstitial lung disease 220.52 9.89 171 482664 139163 109967301
Coronary arterial stent insertion 217.03 9.89 191 482644 5724 110100740
Coronary artery bypass 197.86 9.89 183 482652 5859 110100605
Hepatic function abnormal 191.34 9.89 75 482760 89220 110017244
Dehydration 186.26 9.89 1953 480882 277558 109828906
Lactic acidosis 179.95 9.89 843 481992 91968 110014496
Pancreatitis 175.85 9.89 842 481993 92691 110013773
Hepatic cytolysis 165.81 9.89 22 482813 55031 110051433
Hypotensive transfusion reaction 165.48 9.89 44 482791 43 110106421
Cytomegalovirus infection 154.21 9.89 26 482809 54418 110052046
Cytokine release syndrome 147.45 9.89 61 482774 70245 110036219
Thrombocytopenia 143.30 9.89 913 481922 347972 109758492
Dizziness 138.55 9.89 4009 478826 694184 109412280
C-reactive protein increased 135.19 9.89 492 482343 217427 109889037
Septic shock 134.91 9.89 305 482530 157223 109949241
Therapeutic product effect incomplete 131.88 9.89 516 482319 223289 109883175
Chest pain 129.47 9.89 2336 480499 374039 109732425
Renal failure 129.40 9.89 1536 481299 225038 109881426
Hypovolaemia 123.89 9.89 285 482550 21389 110085075
Drug resistance 123.02 9.89 46 482789 56328 110050136
Blood glucose increased 117.37 9.89 984 481851 131512 109974952
Product dose omission issue 116.28 9.89 2013 480822 319769 109786695
Altered state of consciousness 116.09 9.89 53 482782 57573 110048891
Neutrophil count decreased 115.51 9.89 220 482615 120721 109985743
Arterial occlusive disease 114.98 9.89 225 482610 15083 110091381
Hepatitis 113.93 9.89 135 482700 89919 110016545
Mucosal inflammation 113.43 9.89 152 482683 95989 110010475
Erythema 111.46 9.89 779 482056 290668 109815796
Agranulocytosis 110.80 9.89 66 482769 61694 110044770
Leukopenia 109.66 9.89 311 482524 148480 109957984
Mental status changes 109.22 9.89 636 482199 75486 110030978
Injury 107.11 9.89 1215 481620 176050 109930414
Gangrene 107.11 9.89 227 482608 16114 110090350
Psoriasis 106.66 9.89 1006 481829 138987 109967477
Pancytopenia 101.96 9.89 519 482316 209094 109897370
Angina unstable 101.67 9.89 223 482612 16209 110090255
Sopor 100.15 9.89 19 482816 36527 110069937
Bronchopulmonary aspergillosis 100.07 9.89 8 482827 29855 110076609
Malignant neoplasm progression 98.09 9.89 410 482425 174157 109932307
Product use in unapproved indication 97.33 9.89 1371 481464 446006 109660458
Cholestasis 96.09 9.89 84 482751 64434 110042030
Oxygen saturation decreased 95.65 9.89 357 482478 156625 109949839
Dysphagia 95.15 9.89 1058 481777 152542 109953922
Lupus vulgaris 95.11 9.89 345 482490 33538 110072926
Coma 94.72 9.89 236 482599 117633 109988831
Pharyngeal oedema 93.87 9.89 216 482619 16212 110090252
Adjustment disorder with depressed mood 93.56 9.89 410 482425 43473 110062991
Red blood cell sedimentation rate abnormal 93.30 9.89 3 482832 24506 110081958
Carotid artery thrombosis 90.50 9.89 156 482679 9482 110096982
Syncope 90.10 9.89 1312 481523 201224 109905240
Blood cholesterol increased 88.21 9.89 1212 481623 183573 109922891
Neurologic neglect syndrome 87.97 9.89 151 482684 9147 110097317
Pneumocystis jirovecii pneumonia 85.00 9.89 40 482795 42695 110063769
Therapy partial responder 84.71 9.89 28 482807 37033 110069431
Blood potassium increased 84.57 9.89 328 482507 32921 110073543
Asthenia 84.45 9.89 3746 479089 685253 109421211
Bronchiectasis 84.42 9.89 27 482808 36466 110069998
Sedation 83.39 9.89 109 482726 69574 110036890
Blood pressure fluctuation 82.61 9.89 124 482711 74700 110031764
International normalised ratio increased 81.99 9.89 654 482181 86118 110020346
Liver injury 80.75 9.89 1008 481827 149405 109957059
Infusion related reaction 80.45 9.89 1175 481660 379987 109726477
Thrombotic microangiopathy 80.21 9.89 15 482820 29134 110077330
Distributive shock 79.79 9.89 113 482722 5791 110100673
Renal injury 79.64 9.89 220 482615 18493 110087971
Myocardial ischaemia 79.44 9.89 277 482558 26407 110080057
Premature delivery 77.68 9.89 19 482816 30613 110075851
Bone marrow failure 77.23 9.89 83 482752 57765 110048699
Adjustment disorder 76.67 9.89 155 482680 10640 110095824
Angina pectoris 76.47 9.89 500 482335 61795 110044669
Lymphopenia 76.28 9.89 40 482795 40130 110066334
Blood pressure diastolic abnormal 76.12 9.89 11 482824 25804 110080660
Renal tubular necrosis 75.37 9.89 298 482537 30177 110076287
Gastrointestinal haemorrhage 75.11 9.89 1076 481759 164442 109942022
General physical health deterioration 74.86 9.89 1356 481479 423939 109682525
Autoimmune disorder 74.64 9.89 516 482319 64967 110041497
Intentional self-injury 74.50 9.89 35 482800 37394 110069070
Drug intolerance 74.45 9.89 1287 481548 405225 109701239
Finger deformity 73.90 9.89 26 482809 33066 110073398
Therapy cessation 73.84 9.89 389 482446 44468 110061996
Coeliac disease 73.54 9.89 49 482786 43138 110063326
Abortion spontaneous 73.10 9.89 29 482806 34253 110072211
Aspergillus infection 73.06 9.89 12 482823 25604 110080860
Tongue oedema 72.81 9.89 130 482705 8126 110098338
Blood urea increased 72.34 9.89 449 482386 54508 110051956
Dislocation of vertebra 71.86 9.89 379 482456 43342 110063122
Labile blood pressure 71.69 9.89 70 482765 2401 110104063
Type 2 diabetes mellitus 70.68 9.89 1127 481708 176105 109930359
Condition aggravated 70.63 9.89 2561 480274 732275 109374189
Ischaemic cardiomyopathy 70.47 9.89 126 482709 7885 110098579
Deep vein thrombosis postoperative 70.43 9.89 472 482363 58819 110047645
Drug reaction with eosinophilia and systemic symptoms 70.23 9.89 159 482676 81936 110024528
Hepatotoxicity 70.05 9.89 105 482730 63295 110043169
Hypophagia 69.93 9.89 431 482404 52195 110054269
Inappropriate schedule of product administration 69.87 9.89 561 482274 203076 109903388
Swollen joint count increased 68.67 9.89 611 482224 83050 110023414
Hepatocellular injury 68.35 9.89 72 482763 50570 110055894
Amnesia 67.54 9.89 731 482104 104677 110001787
Depressed level of consciousness 66.66 9.89 258 482577 112020 109994444
Onychomycosis 66.59 9.89 43 482792 38488 110067976
Skin haemorrhage 66.50 9.89 249 482586 24578 110081886
Cardiac disorder 66.21 9.89 564 482271 75716 110030748
Toxic skin eruption 66.10 9.89 19 482816 27496 110078968
Electrocardiogram T wave peaked 66.08 9.89 49 482786 1143 110105321
Retinitis 65.87 9.89 298 482537 32029 110074435
Blood pressure systolic abnormal 65.84 9.89 14 482821 24836 110081628
COVID-19 65.27 9.89 719 482116 244341 109862123
Onychomadesis 64.97 9.89 62 482773 45601 110060863
Eosinophilia 64.94 9.89 95 482740 57841 110048623
Haematotoxicity 64.51 9.89 8 482827 21074 110085390
Cytomegalovirus infection reactivation 64.06 9.89 4 482831 18329 110088135
Pancreatitis acute 62.35 9.89 464 482371 59810 110046654
Anaemia 62.15 9.89 1866 480969 545220 109561244
Product quality issue 61.63 9.89 561 482274 76738 110029726
Disease progression 61.08 9.89 726 482109 243308 109863156
Chronic sinusitis 60.86 9.89 17 482818 25067 110081397
Status epilepticus 60.60 9.89 31 482804 31540 110074924
Haemophagocytic lymphohistiocytosis 60.56 9.89 31 482804 31528 110074936
Febrile bone marrow aplasia 60.47 9.89 4 482831 17461 110089003
Multiple organ dysfunction syndrome 60.19 9.89 401 482434 151309 109955155
Disseminated intravascular coagulation 59.98 9.89 55 482780 41231 110065233
No adverse event 59.95 9.89 538 482297 73301 110033163
Memory impairment 59.95 9.89 1200 481635 195744 109910720
Sedation complication 59.63 9.89 8 482827 19847 110086617
Blood creatinine increased 59.27 9.89 1125 481710 181764 109924700
Oedema 58.87 9.89 1264 481571 208712 109897752
Personality disorder 58.73 9.89 155 482680 12682 110093782
Alanine aminotransferase increased 58.66 9.89 516 482319 183257 109923207
Shock 57.41 9.89 416 482419 53172 110053292
Overdose 57.19 9.89 699 482136 233095 109873369
Intentional dose omission 56.82 9.89 205 482630 19875 110086589
Sinus disorder 56.77 9.89 288 482547 32440 110074024
Productive cough 56.71 9.89 281 482554 114024 109992440
Female genital tract fistula 56.56 9.89 4 482831 16515 110089949
Lymphocyte count decreased 56.54 9.89 102 482733 57141 110049323
Blood pressure systolic increased 56.44 9.89 180 482655 82811 110023653
Pneumonia 56.23 9.89 3193 479642 873521 109232943
Ulcer haemorrhage 56.05 9.89 221 482614 22350 110084114
Dysphonia 56.01 9.89 542 482293 75387 110031077
Blood pressure inadequately controlled 55.89 9.89 111 482724 7522 110098942
Bradycardia 55.43 9.89 971 481864 154546 109951918
Cognitive disorder 55.28 9.89 196 482639 87315 110019149
Coordination abnormal 54.77 9.89 237 482598 24991 110081473
Neurotoxicity 54.76 9.89 62 482773 42145 110064319
Gamma-glutamyltransferase increased 54.70 9.89 116 482719 61193 110045271
Exostosis 54.68 9.89 366 482469 45590 110060874
Aplastic anaemia 54.45 9.89 19 482816 24289 110082175
Exposure during pregnancy 54.36 9.89 468 482367 166956 109939508
Vascular graft 53.95 9.89 56 482779 2069 110104395
Anhedonia 53.83 9.89 169 482666 15259 110091205
Affect lability 53.36 9.89 191 482644 18446 110088018
Drug hypersensitivity 53.16 9.89 2458 480377 451632 109654832
Glycosylated haemoglobin increased 52.90 9.89 224 482611 23395 110083069
Hypertensive emergency 52.65 9.89 69 482766 3282 110103182
Immune reconstitution inflammatory syndrome 52.59 9.89 5 482830 16221 110090243
Muscle spasms 51.94 9.89 1586 481249 276571 109829893
Poisoning deliberate 51.83 9.89 25 482810 26306 110080158
Anxiety 51.59 9.89 1917 480918 343161 109763303
Pneumonitis 51.34 9.89 167 482668 76364 110030100
Rheumatoid nodule 50.67 9.89 13 482822 20283 110086181
Renal tubular acidosis 50.55 9.89 81 482754 4634 110101830
Rash maculo-papular 50.46 9.89 161 482674 74061 110032403
Cardiac failure 50.14 9.89 550 482285 187076 109919388
Prescribed overdose 49.62 9.89 593 482242 86988 110019476
Atrial fibrillation 49.11 9.89 1332 481503 228310 109878154
Fear 48.91 9.89 216 482619 22977 110083487
Progressive multifocal leukoencephalopathy 48.66 9.89 24 482811 24932 110081532
Drug use disorder 48.26 9.89 10 482825 18064 110088400
Peripheral venous disease 47.86 9.89 570 482265 83547 110022917
Post transplant lymphoproliferative disorder 47.59 9.89 6 482829 15607 110090857
Neuroleptic malignant syndrome 47.58 9.89 47 482788 34012 110072452
Contraindicated product administered 47.04 9.89 781 482054 247486 109858978
Product label confusion 47.03 9.89 20 482815 22657 110083807
Haematochezia 47.01 9.89 303 482532 115221 109991243
Drug dependence 46.87 9.89 92 482743 49928 110056536
Blood sodium decreased 46.69 9.89 307 482528 38012 110068452
X-ray abnormal 46.21 9.89 305 482530 37812 110068652
Oral candidiasis 45.80 9.89 78 482757 44682 110061782
Extrapyramidal disorder 44.93 9.89 36 482799 28831 110077633
Adverse reaction 44.71 9.89 38 482797 29556 110076908
Foetal death 44.70 9.89 8 482827 16037 110090427
Sensory loss 44.62 9.89 199 482636 21258 110085206
Coronary artery occlusion 44.61 9.89 161 482674 15611 110090853
Hyperbilirubinaemia 44.39 9.89 41 482794 30630 110075834
Skin exfoliation 44.32 9.89 581 482254 87070 110019394
Immune effector cell-associated neurotoxicity syndrome 44.29 9.89 6 482829 14776 110091688
Oedema mouth 43.92 9.89 61 482774 3069 110103395
Epstein-Barr virus infection 43.10 9.89 14 482821 18724 110087740
Lower limb fracture 43.05 9.89 511 482324 74837 110031627
Transplant rejection 43.02 9.89 27 482808 24540 110081924
Transient ischaemic attack 42.98 9.89 448 482387 63534 110042930
Panniculitis 42.91 9.89 8 482827 15574 110090890
Forced expiratory volume decreased 42.87 9.89 4 482831 13172 110093292
Hypogammaglobulinaemia 42.78 9.89 17 482818 20059 110086405
Intentional product use issue 42.76 9.89 793 482042 247113 109859351
Dysarthria 42.70 9.89 558 482277 83563 110022901
Blood lactate dehydrogenase increased 42.01 9.89 81 482754 44253 110062211
Nodular rash 41.77 9.89 23 482812 313 110106151
Cystitis haemorrhagic 41.68 9.89 3 482832 12206 110094258
Walking aid user 41.64 9.89 218 482617 24857 110081607
Tenosynovitis 41.48 9.89 10 482825 16273 110090191
Infection 41.43 9.89 1234 481601 360966 109745498
Blood glucose decreased 41.40 9.89 245 482590 29243 110077221
Tuberculosis 41.38 9.89 13 482822 17761 110088703
Chronic kidney disease 41.24 9.89 512 482323 75779 110030685
Product use issue 41.05 9.89 1041 481794 310654 109795810
Toxic epidermal necrolysis 40.74 9.89 120 482715 56607 110049857
Product complaint 40.69 9.89 144 482691 13828 110092636
Spinal stenosis 40.59 9.89 178 482657 18878 110087586
Multiple-drug resistance 40.55 9.89 5 482830 13230 110093234
Polyneuropathy 40.47 9.89 48 482787 31964 110074500
Respiratory tract infection 40.34 9.89 168 482667 71449 110035015
Pancreatitis necrotising 40.28 9.89 80 482755 5421 110101043
Body temperature decreased 40.01 9.89 62 482773 36873 110069591
Graft versus host disease 39.95 9.89 16 482819 18790 110087674
Eczema 39.85 9.89 171 482664 72122 110034342
Venoocclusive liver disease 39.41 9.89 9 482826 15198 110091266
Lupus-like syndrome 39.38 9.89 309 482526 40483 110065981
Device interaction 39.13 9.89 30 482805 737 110105727
Blood electrolytes abnormal 38.84 9.89 47 482788 2061 110104403
Aphthous ulcer 38.74 9.89 22 482813 21114 110085350
Treatment failure 38.66 9.89 918 481917 276316 109830148
Grip strength 38.44 9.89 107 482728 9034 110097430
Pseudomonas infection 38.26 9.89 39 482796 27814 110078650
Schizophrenia 38.20 9.89 24 482811 21802 110084662
Hyperthermia 37.78 9.89 23 482812 21249 110085215
Liver function test increased 37.71 9.89 229 482606 88319 110018145
Anti-cyclic citrullinated peptide antibody 37.70 9.89 180 482655 19784 110086680
Road traffic accident 37.70 9.89 669 482166 106729 109999735
Drooling 37.67 9.89 91 482744 7048 110099416
Second primary malignancy 37.36 9.89 16 482819 18052 110088412
Rheumatoid factor positive 37.06 9.89 793 482042 130847 109975617
Emotional distress 37.04 9.89 328 482507 44519 110061945
Back disorder 36.91 9.89 185 482650 20737 110085727
Gait disturbance 36.29 9.89 1523 481312 276685 109829779
Sepsis 36.02 9.89 1121 481714 326225 109780239
Immunodeficiency 35.90 9.89 72 482763 38766 110067698
Haemorrhage intracranial 35.85 9.89 233 482602 28736 110077728
Aspartate aminotransferase increased 35.83 9.89 487 482348 159449 109947015
Abdominal distension 35.79 9.89 543 482292 174560 109931904
Cardiomyopathy 35.76 9.89 260 482575 33265 110073199
Herpes zoster 35.60 9.89 302 482533 108077 109998387
Transaminases increased 35.52 9.89 149 482686 63241 110043223
Sinus congestion 35.29 9.89 241 482594 30218 110076246
Hypoaesthesia 35.27 9.89 1694 481141 312529 109793935
Sciatica 35.12 9.89 583 482252 91816 110014648
Proctitis 34.99 9.89 15 482820 16912 110089552
Acute myeloid leukaemia 34.93 9.89 71 482764 38039 110068425
Lymphomatoid papulosis 34.74 9.89 22 482813 393 110106071
Maternal exposure during pregnancy 34.70 9.89 847 481988 254036 109852428
Respiratory symptom 34.67 9.89 11 482824 14934 110091530
Rotator cuff repair 34.59 9.89 46 482789 2220 110104244
Enterocolitis 34.34 9.89 20 482815 18929 110087535
Somatic delusion 34.17 9.89 27 482808 694 110105770
Drug eruption 34.01 9.89 120 482715 53539 110052925
Accelerated hypertension 33.87 9.89 28 482807 769 110105695
Mouth ulceration 33.72 9.89 103 482732 48035 110058429
Haemodialysis 33.64 9.89 160 482675 17559 110088905
Appendicitis 33.57 9.89 45 482790 28419 110078045
Miosis 33.49 9.89 28 482807 21955 110084509
Myelodysplastic syndrome 33.37 9.89 71 482764 37413 110069051
Pharyngeal swelling 33.33 9.89 122 482713 11910 110094554
Colitis 33.22 9.89 286 482549 102037 110004427
Dermatitis atopic 33.19 9.89 208 482627 25333 110081131
Somnolence 33.11 9.89 1017 481818 296432 109810032
Eating disorder 32.74 9.89 239 482596 30619 110075845
Discomfort 32.60 9.89 1195 481640 213512 109892952
Diarrhoea 32.46 9.89 5551 477284 1133954 108972510
Sneezing 32.39 9.89 245 482590 31739 110074725
Depression 32.35 9.89 1695 481140 315640 109790824
Stridor 32.31 9.89 84 482751 6811 110099653
Dizziness postural 32.29 9.89 138 482697 14471 110091993
Generalised tonic-clonic seizure 32.23 9.89 126 482709 54554 110051910
Vision blurred 32.17 9.89 764 482071 128258 109978206
Neutropenic sepsis 31.99 9.89 53 482782 30693 110075771
Oral allergy syndrome 31.94 9.89 13 482822 84 110106380
Cytomegalovirus viraemia 31.84 9.89 19 482816 17745 110088719
Suicide attempt 31.80 9.89 293 482542 103101 110003363
Arthralgia 31.63 9.89 2952 479883 776680 109329784
Mydriasis 31.62 9.89 30 482805 22127 110084337
BK virus infection 31.58 9.89 9 482826 13097 110093367
Blood urea abnormal 31.32 9.89 40 482795 1854 110104610
Synovitis 31.28 9.89 934 481901 273158 109833306
Motor dysfunction 31.24 9.89 198 482637 24208 110082256
Encephalitis 31.24 9.89 22 482813 18817 110087647
Body temperature increased 31.03 9.89 128 482707 54585 110051879
General symptom 30.95 9.89 97 482738 8749 110097715
Laryngitis 30.91 9.89 302 482533 42109 110064355
Psoriatic arthropathy 30.82 9.89 1099 481736 195662 109910802
Epilepsy 30.81 9.89 284 482551 99925 110006539
Laboratory test abnormal 30.73 9.89 311 482524 43768 110062696
Candida infection 30.67 9.89 107 482728 47902 110058562
Nodule 30.59 9.89 60 482775 32571 110073893
Vasoplegia syndrome 30.51 9.89 71 482764 5368 110101096
Platelet count decreased 30.50 9.89 769 482066 229674 109876790
Uveitis 30.28 9.89 30 482805 21680 110084784
Vasculitis 30.26 9.89 70 482765 35803 110070661
Hemiparesis 30.25 9.89 309 482526 43594 110062870
Lip dry 30.16 9.89 609 482226 99474 110006990
Rheumatic fever 30 9.89 724 482111 121855 109984609
Lung opacity 29.99 9.89 7 482828 11645 110094819
Aphasia 29.79 9.89 391 482444 58606 110047858
Subcutaneous drug absorption impaired 29.63 9.89 87 482748 7572 110098892
Osteoarthritis 29.59 9.89 1024 481811 181599 109924865
Hyperlipidaemia 29.51 9.89 262 482573 35586 110070878
Hypoaldosteronism 29.47 9.89 24 482811 645 110105819
Product substitution issue 29.47 9.89 187 482648 22874 110083590
Dermatitis exfoliative generalised 29.44 9.89 6 482829 10966 110095498
Dilatation atrial 29.39 9.89 57 482778 3795 110102669
Diabetic foot infection 29.38 9.89 27 482808 857 110105607
Essential hypertension 29.28 9.89 88 482747 7759 110098705
Hemiplegia 29.27 9.89 185 482650 22597 110083867
Dystonia 29.23 9.89 42 482793 25763 110080701
Bacterial infection 29.14 9.89 103 482732 45933 110060531
Pulmonary alveolar haemorrhage 29.09 9.89 27 482808 20123 110086341
Neck pain 29.02 9.89 371 482464 122759 109983705
Caesarean section 28.95 9.89 12 482823 13805 110092659
Grip strength decreased 28.70 9.89 501 482334 79673 110026791
Blood pressure increased 28.58 9.89 1391 481444 256982 109849482
Cytopenia 28.56 9.89 55 482780 30061 110076403
Diabetic neuropathy 28.52 9.89 81 482754 6918 110099546
Product coating issue 28.47 9.89 13 482822 115 110106349
Graft versus host disease in gastrointestinal tract 28.45 9.89 3 482832 8965 110097499
Orbital myositis 28.11 9.89 16 482819 233 110106231
Device related infection 28.08 9.89 84 482751 39435 110067029
Mouth swelling 27.94 9.89 83 482752 7271 110099193
Blood pressure diastolic decreased 27.93 9.89 73 482762 35812 110070652
Pelvic mass 27.84 9.89 33 482802 1416 110105048
Mixed liver injury 27.83 9.89 9 482826 12070 110094394
Intestinal ischaemia 27.80 9.89 142 482693 16037 110090427
Anaphylactic shock 27.75 9.89 123 482712 51423 110055041
Oral herpes 27.62 9.89 74 482761 36006 110070458
Pathogen resistance 27.55 9.89 22 482813 17650 110088814
Metabolic acidosis 27.48 9.89 599 482236 99145 110007319
Ventricular hypertrophy 27.23 9.89 80 482755 6965 110099499
Bradypnoea 27.17 9.89 3 482832 8646 110097818
Full blood count decreased 27.15 9.89 236 482599 31863 110074601
Systemic infection 27.13 9.89 5 482830 9814 110096650
Temperature regulation disorder 27.10 9.89 11 482824 12815 110093649
Porphyria acute 26.99 9.89 157 482678 18623 110087841
Arteriosclerosis 26.95 9.89 193 482642 24574 110081890
Adverse drug reaction 26.91 9.89 627 482208 104932 110001532
Laryngeal oedema 26.80 9.89 99 482736 9708 110096756
Hypothyroidism 26.79 9.89 197 482638 72702 110033762
Pulmonary tuberculosis 26.70 9.89 4 482831 9135 110097329
Unresponsive to stimuli 26.69 9.89 409 482426 63381 110043083
Ulcer 26.28 9.89 98 482737 43018 110063446
Anal abscess 26.24 9.89 9 482826 11629 110094835
Joint range of motion decreased 26.12 9.89 707 482128 121125 109985339
Knee arthroplasty 25.87 9.89 413 482422 64535 110041929
Unintentional medical device removal 25.85 9.89 4 482831 8919 110097545
Confusional state 25.81 9.89 2379 480456 466301 109640163
Adenovirus infection 25.67 9.89 8 482827 10986 110095478
Shock haemorrhagic 25.63 9.89 50 482785 27197 110079267
Inflammation 25.52 9.89 645 482190 192593 109913871
Peripheral vascular disorder 25.50 9.89 89 482746 8487 110097977
Oropharyngeal pain 25.46 9.89 426 482409 134850 109971614
Ear infection 25.40 9.89 400 482435 62332 110044132
Colitis ischaemic 25.25 9.89 148 482687 17602 110088862
Atrioventricular block first degree 25.25 9.89 126 482709 14099 110092365
Respiratory tract congestion 25.13 9.89 225 482610 30632 110075832
Paradoxical drug reaction 25.07 9.89 6 482829 9811 110096653
Stent placement 25.01 9.89 79 482756 7155 110099309
Hypertensive urgency 25.00 9.89 28 482807 1129 110105335
Similar reaction on previous exposure to drug 24.92 9.89 12 482823 121 110106343
Infective pulmonary exacerbation of cystic fibrosis 24.83 9.89 17 482818 14754 110091710
Pneumonia aspiration 24.64 9.89 231 482604 81002 110025462
Non-cardiac chest pain 24.64 9.89 99 482736 10099 110096365
Hip arthroplasty 24.58 9.89 361 482474 55452 110051012
Ulnar nerve palsy 24.51 9.89 7 482828 11 110106453
Electrocardiogram QT prolonged 24.32 9.89 332 482503 108628 109997836
Decreased appetite 24.22 9.89 2402 480433 473444 109633020
Eosinophil count increased 24.12 9.89 34 482801 21024 110085440
Breast cancer stage II 24.06 9.89 203 482632 27172 110079292
Aplasia 24.06 9.89 3 482832 7870 110098594
Gastric cancer 23.99 9.89 9 482826 10999 110095465
Vascular device infection 23.98 9.89 22 482813 16490 110089974
Raynaud's phenomenon 23.95 9.89 25 482810 930 110105534
Potassium wasting nephropathy 23.93 9.89 13 482822 172 110106292
Device expulsion 23.92 9.89 63 482772 30828 110075636
Osteonecrosis of jaw 23.84 9.89 118 482717 47899 110058565
Prostate cancer recurrent 23.80 9.89 25 482810 937 110105527
Adverse event 23.78 9.89 633 482202 108176 109998288
Constipation 23.78 9.89 1298 481537 356488 109749976
Chronic graft versus host disease 23.72 9.89 6 482829 9451 110097013
Wound infection 23.68 9.89 570 482265 95895 110010569
Vaginal discharge 23.56 9.89 26 482809 17882 110088582
Atrioventricular block second degree 23.55 9.89 84 482751 8097 110098367
Skin toxicity 23.48 9.89 11 482824 11772 110094692
Myasthenia gravis 23.40 9.89 36 482799 21475 110084989
Rhinitis 23.33 9.89 39 482796 22506 110083958
Dialysis 23.19 9.89 156 482679 19463 110087001
Pulmonary toxicity 23.09 9.89 26 482809 17720 110088744
Drug-induced liver injury 22.96 9.89 377 482458 119690 109986774
Disability 22.91 9.89 217 482618 30006 110076458
Nephrogenic systemic fibrosis 22.88 9.89 64 482771 5419 110101045
Gastrointestinal toxicity 22.85 9.89 10 482825 11138 110095326
Eosinophilic granulomatosis with polyangiitis 22.85 9.89 9 482826 10677 110095787
Hyperammonaemia 22.82 9.89 16 482819 13716 110092748
Hepatitis acute 22.82 9.89 29 482806 18737 110087727
Device dislocation 22.81 9.89 67 482768 31637 110074827
Immune-mediated enterocolitis 22.75 9.89 8 482827 10177 110096287
Lip oedema 22.71 9.89 79 482756 7521 110098943
Neoplasm progression 22.58 9.89 177 482658 64418 110042046
Rhabdomyolysis 22.58 9.89 687 482148 119714 109986750
Neutropenic colitis 22.51 9.89 4 482831 8061 110098403
Hepatitis B reactivation 22.51 9.89 3 482832 7481 110098983
Hypoglycaemia 22.45 9.89 665 482170 115439 109991025
Hyperphosphataemia 22.43 9.89 23 482812 16358 110090106
Breast cancer stage III 22.39 9.89 477 482358 78640 110027824
Muscular weakness 22.34 9.89 1312 481523 247156 109859308
Acute coronary syndrome 22.27 9.89 175 482660 22937 110083527
Tumour lysis syndrome 22.23 9.89 65 482770 30736 110075728
Blood bilirubin increased 22.21 9.89 218 482617 75754 110030710
Erectile dysfunction 22.20 9.89 148 482687 18408 110088056
Pseudomonal sepsis 22.19 9.89 6 482829 9040 110097424
Hypocholesterolaemia 22.09 9.89 70 482765 6351 110100113
Muscle relaxant therapy 22.01 9.89 12 482823 160 110106304
Rhinovirus infection 22.00 9.89 12 482823 11777 110094687
Acute generalised exanthematous pustulosis 21.94 9.89 38 482797 21626 110084838
Device difficult to use 21.90 9.89 30 482805 18775 110087689
Acne 21.89 9.89 74 482761 33446 110073018
Hallucination, auditory 21.87 9.89 52 482783 26345 110080119
Metastases to lymph nodes 21.87 9.89 20 482815 15012 110091452
Blood loss anaemia 21.71 9.89 144 482691 17881 110088583
No reaction on previous exposure to drug 21.63 9.89 14 482821 260 110106204
Hepatic ischaemia 21.61 9.89 27 482808 1224 110105240
Eye swelling 21.54 9.89 230 482605 32818 110073646
Wheezing 21.50 9.89 1340 481495 253890 109852574
Fistula 21.50 9.89 21 482814 15278 110091186
Fibromyalgia 21.46 9.89 932 481903 169977 109936487
Enthesopathy 21.46 9.89 14 482821 12464 110094000
Acute respiratory distress syndrome 21.40 9.89 140 482695 53058 110053406
Dry mouth 21.38 9.89 1073 481762 198875 109907589
Haemolysis 21.37 9.89 22 482813 15617 110090847
Concomitant disease aggravated 21.27 9.89 24 482811 16340 110090124
Graft versus host disease in skin 21.16 9.89 5 482830 8249 110098215
Unevaluable event 21.16 9.89 370 482465 58857 110047607
Adrenal insufficiency 21.14 9.89 104 482731 42286 110064178
Ischaemic hepatitis 21.14 9.89 56 482779 4592 110101872
Food allergy 21.12 9.89 34 482801 19914 110086550
Nasal congestion 21.04 9.89 302 482533 97980 110008484
COVID-19 pneumonia 21.00 9.89 87 482748 37056 110069408
Fatigue 20.98 9.89 5785 477050 1210173 108896291
Ovarian cyst 20.91 9.89 18 482817 13912 110092552
Full blood count abnormal 20.82 9.89 151 482684 55901 110050563
Blood parathyroid hormone decreased 20.78 9.89 16 482819 13073 110093391
Ageusia 20.75 9.89 152 482683 19493 110086971
Blood uric acid increased 20.69 9.89 39 482796 21490 110084974
Tinnitus 20.65 9.89 167 482668 60373 110046091
Posterior reversible encephalopathy syndrome 20.62 9.89 77 482758 33784 110072680
Asphyxia 20.57 9.89 19 482816 14196 110092268
Diverticulum 20.52 9.89 127 482708 15399 110091065
Intestinal obstruction 20.45 9.89 142 482693 53085 110053379
Withdrawal hypertension 20.39 9.89 16 482819 407 110106057
Overlap syndrome 20.35 9.89 86 482749 8973 110097491
Suspected suicide attempt 20.26 9.89 15 482820 349 110106115
Ankylosing spondylitis 20.18 9.89 23 482812 15589 110090875
Oedema genital 20.17 9.89 19 482816 623 110105841
Sputum discoloured 20.15 9.89 59 482776 27886 110078578
Diabetic ketoacidosis 20.11 9.89 276 482559 41782 110064682
Rash vesicular 20.10 9.89 121 482714 14531 110091933
Carotid artery stenosis 20.09 9.89 87 482748 9176 110097288
Substance abuse 20.09 9.89 15 482820 12448 110094016
Peripheral sensory neuropathy 20.05 9.89 26 482809 16654 110089810
Penile swelling 20.03 9.89 21 482814 785 110105679
Joint effusion 19.98 9.89 38 482797 20867 110085597
Product monitoring error 19.96 9.89 7 482828 8920 110097544
Night sweats 19.91 9.89 744 482091 133239 109973225
Mitral valve incompetence 19.91 9.89 228 482607 33101 110073363
Nasal polyps 19.88 9.89 17 482818 13183 110093281
Thermohypoaesthesia 19.86 9.89 10 482825 112 110106352
Refusal of treatment by patient 19.70 9.89 88 482747 9406 110097058
Pallor 19.61 9.89 155 482680 56312 110050152
Enterococcal infection 19.48 9.89 37 482798 20329 110086135
Therapeutic product effect decreased 19.40 9.89 870 481965 243446 109863018
Electrocardiogram T wave abnormal 19.37 9.89 51 482784 4166 110102298
Electrocardiogram change 19.36 9.89 27 482808 1364 110105100
Fall 19.28 9.89 2959 479876 600523 109505941
Tachycardia 19.26 9.89 801 482034 225844 109880620
Behaviour disorder 19.23 9.89 9 482826 9638 110096826
Burns second degree 19.21 9.89 5 482830 7728 110098736
Premature labour 19.16 9.89 8 482827 9164 110097300
Renal artery stenosis 19.13 9.89 47 482788 3679 110102785
Pulseless electrical activity 19.06 9.89 132 482703 16625 110089839
Blister 19.01 9.89 1193 481642 226183 109880281
Injection site reaction 18.96 9.89 274 482561 88796 110017668
Skin necrosis 18.94 9.89 41 482794 21471 110084993
Influenza like illness 18.93 9.89 513 482322 87899 110018565
Bone erosion 18.90 9.89 296 482539 46075 110060389
Heart rate increased 18.75 9.89 481 482354 143353 109963111
Acquired acrodermatitis enteropathica 18.75 9.89 5 482830 5 110106459
Seizure 18.73 9.89 782 482053 220403 109886061
Myxoedema coma 18.73 9.89 19 482816 683 110105781
Blood test abnormal 18.67 9.89 63 482772 28491 110077973
Metastases to lung 18.66 9.89 46 482789 23017 110083447
Psychomotor skills impaired 18.65 9.89 4 482831 7054 110099410
Oedema peripheral 18.64 9.89 1672 481163 326988 109779476
Abdominal pain upper 18.59 9.89 1768 481067 347343 109759121
Benign gastrointestinal neoplasm 18.56 9.89 10 482825 130 110106334
Herpes simplex 18.51 9.89 25 482810 15739 110090725
Neutrophil count increased 18.47 9.89 83 482752 34569 110071895
Toe amputation 18.46 9.89 51 482784 4287 110102177
Back injury 18.43 9.89 126 482709 47273 110059191
Abortion induced 18.43 9.89 6 482829 8013 110098451
Azotaemia 18.38 9.89 90 482745 9995 110096469
C-reactive protein 18.35 9.89 208 482627 30123 110076341
Prostate tenderness 18.32 9.89 8 482827 63 110106401
Cardiac arrest 18.27 9.89 1042 481793 195711 109910753
Oropharyngeal swelling 18.15 9.89 27 482808 1447 110105017
Fracture 18.11 9.89 52 482783 24736 110081728
Brain oedema 18.11 9.89 72 482763 31026 110075438
Drug dose omission by device 18.10 9.89 22 482813 14494 110091970
Procedural pain 17.88 9.89 87 482748 35478 110070986
Diffuse large B-cell lymphoma 17.88 9.89 26 482809 15872 110090592
Urethral prolapse 17.75 9.89 4 482831 0 110106464
Carcinoid tumour of the small bowel 17.75 9.89 15 482820 425 110106039
Radiculopathy 17.74 9.89 36 482799 19300 110087164
Loss of personal independence in daily activities 17.66 9.89 509 482326 149511 109956953
Rheumatoid arthritis 17.57 9.89 1528 481307 298085 109808379
Pulmonary renal syndrome 17.57 9.89 20 482815 821 110105643
Heart rate decreased 17.46 9.89 255 482580 82501 110023963
Paraesthesia 17.45 9.89 1418 481417 275103 109831361
Liver abscess 17.42 9.89 6 482829 7733 110098731
Bicytopenia 17.39 9.89 4 482831 6720 110099744
Pre-eclampsia 17.35 9.89 8 482827 8642 110097822
Bone density decreased 17.31 9.89 27 482808 16015 110090449
Feeling abnormal 17.16 9.89 959 481876 179752 109926712
Laryngotracheal oedema 17.10 9.89 7 482828 46 110106418
Labelled drug-drug interaction medication error 16.96 9.89 68 482767 29234 110077230
Fungal infection 16.94 9.89 141 482694 50665 110055799
Total lung capacity decreased 16.93 9.89 5 482830 7109 110099355
Apathy 16.89 9.89 28 482807 16211 110090253
Product prescribing error 16.87 9.89 143 482692 51188 110055276
Lacunar infarction 16.80 9.89 63 482772 6223 110100241
Conjunctivitis 16.80 9.89 83 482752 33709 110072755
Cytomegalovirus colitis 16.73 9.89 5 482830 7056 110099408
Clostridium difficile colitis 16.72 9.89 117 482718 43661 110062803
Speech disorder 16.72 9.89 369 482466 61200 110045264
Drug specific antibody present 16.61 9.89 8 482827 8426 110098038
Respiratory distress 16.61 9.89 406 482429 68468 110037996
Sight disability 16.60 9.89 11 482824 213 110106251
Creatinine renal clearance decreased 16.51 9.89 45 482790 21770 110084694
Lymphoma 16.50 9.89 40 482795 20131 110086333
Blood immunoglobulin E increased 16.50 9.89 6 482829 7476 110098988
Maternal exposure timing unspecified 16.49 9.89 152 482683 20861 110085603
Pollakiuria 16.48 9.89 278 482557 43917 110062547
Enlarged uvula 16.46 9.89 15 482820 471 110105993
Nausea 16.43 9.89 5819 477016 1229871 108876593
Glomerulonephritis minimal lesion 16.43 9.89 22 482813 1069 110105395
Metastases to liver 16.41 9.89 89 482746 35297 110071167
Pneumonia cytomegaloviral 16.34 9.89 5 482830 6949 110099515
Depressed mood 16.34 9.89 178 482657 60631 110045833
Conjunctivitis allergic 16.26 9.89 5 482830 6926 110099538
White blood cell count decreased 16.21 9.89 827 482008 228563 109877901
Occult blood positive 16.20 9.89 70 482765 7375 110099089
Spur cell anaemia 16.19 9.89 9 482826 125 110106339
Neurological symptom 16.15 9.89 27 482808 15581 110090883
Pseudomembranous colitis 16.13 9.89 4 482831 6387 110100077
Myalgia 16.13 9.89 1153 481682 221228 109885236
Neurological decompensation 16.09 9.89 5 482830 6878 110099586
Systemic candida 16.08 9.89 12 482823 9962 110096502
Blood glucose abnormal 16.05 9.89 104 482731 12812 110093652
Torsade de pointes 16.02 9.89 160 482675 22440 110084024
Hypercholesterolaemia 15.89 9.89 514 482321 90323 110016141
Psychotic disorder 15.81 9.89 144 482691 50793 110055671
Psychiatric decompensation 15.79 9.89 3 482832 5762 110100702
Pneumonia fungal 15.76 9.89 25 482810 14729 110091735
Sarcoidosis 15.75 9.89 19 482816 12560 110093904
Lethargy 15.73 9.89 527 482308 93049 110013415
Hypertensive heart disease 15.72 9.89 50 482785 4546 110101918
Brain abscess 15.69 9.89 5 482830 6769 110099695
Hypoalbuminaemia 15.68 9.89 69 482766 28905 110077559
Joint swelling 15.68 9.89 1693 481142 441152 109665312
Lymphoproliferative disorder 15.56 9.89 6 482829 7212 110099252
Infusion site pain 15.50 9.89 33 482802 17386 110089078
Alanine aminotransferase abnormal 15.35 9.89 11 482824 9323 110097141
Facial nerve disorder 15.34 9.89 18 482817 764 110105700
Endometriosis male 15.33 9.89 5 482830 15 110106449
Tachypnoea 15.18 9.89 105 482730 39290 110067174
Factor VII deficiency 15.12 9.89 8 482827 100 110106364
Cataract 15.02 9.89 454 482381 79031 110027433
Carcinoid tumour of the gastrointestinal tract 15.02 9.89 9 482826 145 110106319
Skin reaction 14.98 9.89 45 482790 21099 110085365
Suture rupture 14.97 9.89 17 482818 696 110105768
Blood glucose fluctuation 14.97 9.89 70 482765 7628 110098836
Delirium 14.93 9.89 727 482108 134298 109972166
Visual impairment 14.91 9.89 724 482111 133704 109972760
Enteritis 14.88 9.89 39 482796 19117 110087347
Iron deficiency 14.83 9.89 37 482798 18439 110088025
Pulmonary embolism 14.81 9.89 775 482060 213699 109892765
Swollen joint count 14.81 9.89 76 482759 8598 110097866
Anaphylactic reaction 14.72 9.89 625 482210 113675 109992789
Hepatic cirrhosis 14.65 9.89 393 482442 67233 110039231
Coronary artery surgery 14.65 9.89 9 482826 152 110106312
Colorectal cancer 14.65 9.89 11 482824 9103 110097361
Sinus node dysfunction 14.57 9.89 78 482757 8969 110097495
Pulmonary arterial hypertension 14.51 9.89 83 482752 32485 110073979
Glomerulonephritis membranous 14.51 9.89 29 482806 1974 110104490
Cholangitis 14.49 9.89 31 482804 16304 110090160
Skin infection 14.49 9.89 50 482785 22459 110084005
Parkinsonism 14.48 9.89 49 482786 22138 110084326
Scleritis 14.47 9.89 3 482832 5417 110101047
Jaundice cholestatic 14.45 9.89 26 482809 14582 110091882
Hepatic failure 14.44 9.89 212 482623 68527 110037937
Ileus paralytic 14.41 9.89 18 482817 11719 110094745
Gout 14.37 9.89 232 482603 36334 110070130
Drug dispensed to wrong patient 14.29 9.89 17 482818 732 110105732
Hepatitis cholestatic 14.24 9.89 35 482800 17531 110088933
Macroglossia 14.18 9.89 24 482811 1437 110105027
Abnormal dreams 14.14 9.89 100 482735 12680 110093784
Bronchospasm 14.06 9.89 76 482759 30163 110076301
Pharyngitis 14.05 9.89 59 482776 25039 110081425
Breath sounds abnormal 14.05 9.89 60 482775 25344 110081120
Macular degeneration 14.02 9.89 48 482787 21611 110084853
Musculoskeletal pain 13.98 9.89 953 481882 182070 109924394
JC virus infection 13.97 9.89 3 482832 5287 110101177
Penile contusion 13.97 9.89 8 482827 118 110106346
Metastases to bone 13.96 9.89 80 482755 31292 110075172
Escherichia infection 13.96 9.89 55 482780 23761 110082703
Stevens-Johnson syndrome 13.95 9.89 134 482701 46767 110059697
Sleep attacks 13.95 9.89 10 482825 221 110106243
Hyperpyrexia 13.95 9.89 9 482826 8060 110098404
Fluid intake reduced 13.93 9.89 64 482771 6922 110099542
Product physical issue 13.90 9.89 51 482784 4985 110101479
Klebsiella infection 13.88 9.89 43 482792 19966 110086498
Cerebral thrombosis 13.78 9.89 32 482803 2416 110104048
Multiple drug therapy 13.77 9.89 9 482826 8005 110098459
Arteriosclerosis coronary artery 13.76 9.89 169 482666 24949 110081515
Hepatic encephalopathy 13.70 9.89 70 482765 28186 110078278
Organising pneumonia 13.51 9.89 26 482809 14217 110092247
Sleep terror 13.44 9.89 6 482829 6604 110099860
Bursitis 13.44 9.89 695 482140 129223 109977241
Spinal pain 13.41 9.89 39 482796 18476 110087988
Skin induration 13.41 9.89 46 482789 4349 110102115
Ill-defined disorder 13.40 9.89 554 482281 156299 109950165
Granuloma 13.37 9.89 13 482822 9477 110096987
Hyperprolactinaemia 13.32 9.89 6 482829 6569 110099895
Thyroiditis 13.31 9.89 6 482829 6567 110099897
Complications of transplanted kidney 13.28 9.89 8 482827 7434 110099030
Immune thrombocytopenia 13.15 9.89 52 482783 22442 110084022
Muscle rigidity 13.14 9.89 57 482778 23974 110082490
Hypoglycaemic unconsciousness 13.14 9.89 21 482814 1199 110105265
Foetal disorder 13.13 9.89 8 482827 133 110106331
Disturbance in social behaviour 13.10 9.89 3 482832 5055 110101409
Tonsillitis 13.09 9.89 10 482825 8203 110098261
Clostridium difficile infection 13.06 9.89 155 482680 51974 110054490
Cardiomegaly 13.05 9.89 189 482646 28941 110077523
Infusion site erythema 13.02 9.89 20 482815 11939 110094525
Respiratory tract oedema 13.02 9.89 20 482815 1103 110105361
Hypophosphataemia 13.01 9.89 88 482747 33094 110073370
Skin hypertrophy 13.01 9.89 50 482785 4997 110101467
Aggression 13.00 9.89 181 482654 59029 110047435
Expired product administered 12.91 9.89 71 482764 8249 110098215
Upper gastrointestinal haemorrhage 12.90 9.89 298 482537 49798 110056666
Therapeutic response unexpected 12.88 9.89 160 482675 23683 110082781
Pleural effusion 12.87 9.89 639 482196 177070 109929394
Alcoholic ketoacidosis 12.86 9.89 6 482829 56 110106408
Therapeutic response shortened 12.86 9.89 76 482759 29507 110076957
Colitis ulcerative 12.86 9.89 249 482586 77114 110029350
Subileus 12.84 9.89 6 482829 6431 110100033
Prostate examination abnormal 12.83 9.89 9 482826 192 110106272
Strongyloidiasis 12.82 9.89 3 482832 4983 110101481
Bradykinesia 12.78 9.89 17 482818 10771 110095693
Contusion 12.74 9.89 1184 481651 232177 109874287
Dysaesthesia 12.73 9.89 7 482828 6840 110099624
Palmar-plantar erythrodysaesthesia syndrome 12.73 9.89 116 482719 40909 110065555
Ear pruritus 12.68 9.89 8 482827 7252 110099212
Obesity 12.68 9.89 611 482224 112740 109993724
Duodenal ulcer perforation 12.65 9.89 920 481915 176780 109929684
Anal fistula 12.65 9.89 11 482824 8462 110098002
Acute febrile neutrophilic dermatosis 12.64 9.89 3 482832 4933 110101531
Charles Bonnet syndrome 12.59 9.89 6 482829 59 110106405
Product solubility abnormal 12.51 9.89 20 482815 1142 110105322
Pain in jaw 12.50 9.89 153 482682 51024 110055440
Dysgeusia 12.50 9.89 397 482438 69588 110036876
Gastric ulcer helicobacter 12.46 9.89 5 482830 31 110106433
Exercise tolerance increased 12.46 9.89 5 482830 31 110106433
Endotracheal intubation complication 12.44 9.89 17 482818 842 110105622
Palmoplantar keratoderma 12.43 9.89 4 482831 5383 110101081
Hypopnoea 12.42 9.89 19 482816 11361 110095103
Encephalomalacia 12.42 9.89 23 482812 1479 110104985
Stenotrophomonas infection 12.42 9.89 5 482830 5853 110100611
Nodal rhythm 12.41 9.89 38 482797 3385 110103079
Rebound effect 12.40 9.89 29 482806 14777 110091687
Lymphadenopathy 12.34 9.89 200 482635 63635 110042829
Premature baby 12.33 9.89 3 482832 4852 110101612
Poor venous access 12.32 9.89 60 482775 24462 110082002
Hepatocellular carcinoma 12.29 9.89 15 482820 9865 110096599
Dyspnoea at rest 12.26 9.89 11 482824 8335 110098129
Drug level below therapeutic 12.26 9.89 20 482815 11653 110094811
Urine flow decreased 12.22 9.89 22 482813 1384 110105080
Myocarditis 12.14 9.89 79 482756 29976 110076488
Papillitis 12.11 9.89 8 482827 154 110106310
Cough 12.11 9.89 2240 480595 459401 109647063
Lower respiratory tract congestion 12.11 9.89 3 482832 4793 110101671
Drug level decreased 12.08 9.89 41 482794 18507 110087957
Intracranial pressure increased 12.08 9.89 17 482818 10518 110095946
Multiple injuries 12.07 9.89 39 482796 3575 110102889
Angiotensin converting enzyme inhibitor foetopathy 12.07 9.89 5 482830 34 110106430
Monocyte count increased 11.98 9.89 25 482810 13268 110093196
Lid lag 11.94 9.89 8 482827 158 110106306
Dilatation ventricular 11.87 9.89 42 482793 4033 110102431
Oesophageal carcinoma 11.86 9.89 20 482815 11504 110094960
Cerebral small vessel ischaemic disease 11.83 9.89 23 482812 1534 110104930
Bacteraemia 11.82 9.89 123 482712 42267 110064197
Neuritis 11.80 9.89 9 482826 7390 110099074
Fear of eating 11.79 9.89 13 482822 515 110105949
Terminal state 11.75 9.89 5 482830 5662 110100802
Hypokalaemia 11.72 9.89 664 482171 181784 109924680
Fear of injection 11.66 9.89 13 482822 8898 110097566
Pancreatitis haemorrhagic 11.65 9.89 18 482817 998 110105466
Transient psychosis 11.63 9.89 6 482829 71 110106393
Disseminated tuberculosis 11.57 9.89 4 482831 5142 110101322
Transfusion-related circulatory overload 11.53 9.89 17 482818 904 110105560
Renal cell carcinoma 11.51 9.89 64 482771 7466 110098998
Purpura 11.50 9.89 61 482774 24327 110082137
Vertigo 11.45 9.89 290 482545 86580 110019884
Meningitis 11.42 9.89 21 482814 11681 110094783
Eosinophil count decreased 11.41 9.89 6 482829 6012 110100452
Red cell distribution width increased 11.40 9.89 39 482796 17563 110088901
Erythema marginatum 11.39 9.89 4 482831 16 110106448
Rash erythematous 11.38 9.89 271 482564 81561 110024903
Nasal oedema 11.32 9.89 8 482827 6831 110099633
Electrocardiogram ST-T change 11.29 9.89 23 482812 1587 110104877
Kidney transplant rejection 11.27 9.89 22 482813 11965 110094499
Intercepted product preparation error 11.26 9.89 8 482827 6812 110099652
Tick-borne fever 11.25 9.89 3 482832 3 110106461
Hypoperfusion 11.24 9.89 35 482800 3146 110103318
Hypomania 11.19 9.89 17 482818 10193 110096271
Uvulitis 11.17 9.89 5 482830 42 110106422
Drug level increased 11.16 9.89 144 482691 47575 110058889
Immune-mediated myositis 11.13 9.89 55 482780 6131 110100333
Circulatory collapse 11.09 9.89 127 482708 42866 110063598
Chromaturia 11.06 9.89 185 482650 29175 110077289
Albumin urine present 11.06 9.89 15 482820 738 110105726
Contrast media reaction 11.02 9.89 29 482806 2369 110104095
Vitreous floaters 11.02 9.89 73 482762 9061 110097403
Oesophageal candidiasis 10.99 9.89 21 482814 11513 110094951
Pneumopericardium 10.98 9.89 9 482826 244 110106220
Sinus pain 10.95 9.89 6 482829 5873 110100591
Pyelonephritis 10.91 9.89 65 482770 25185 110081279
Carcinoid tumour of the stomach 10.89 9.89 8 482827 184 110106280
Body temperature 10.88 9.89 5 482830 45 110106419
Hyponatraemia 10.81 9.89 1097 481738 216556 109889908
Metastases to central nervous system 10.80 9.89 57 482778 22760 110083704
Pulse volume decreased 10.79 9.89 3 482832 4 110106460
Sinus arrhythmia 10.75 9.89 27 482808 2143 110104321
Body height decreased 10.74 9.89 81 482754 10482 110095982
Erythema nodosum 10.73 9.89 8 482827 6645 110099819
Bundle branch block right 10.73 9.89 91 482744 12200 110094264
Small intestinal ulcer haemorrhage 10.72 9.89 7 482828 132 110106332
Hospice care 10.70 9.89 92 482743 12381 110094083
Cytomegalovirus test positive 10.67 9.89 9 482826 7027 110099437
Hypomagnesaemia 10.66 9.89 342 482493 60028 110046436
Pneumocystis jirovecii infection 10.64 9.89 3 482832 4397 110102067
Acute lymphocytic leukaemia recurrent 10.64 9.89 6 482829 5781 110100683
Immunosuppressant drug level increased 10.61 9.89 22 482813 11702 110094762
Pulse absent 10.60 9.89 85 482750 11207 110095257
Skin odour abnormal 10.59 9.89 29 482806 2425 110104039
Superinfection 10.56 9.89 6 482829 5757 110100707
Diverticulum intestinal haemorrhagic 10.53 9.89 45 482790 4718 110101746
Obstructive airways disorder 10.52 9.89 140 482695 46009 110060455
Retroperitoneal oedema 10.51 9.89 4 482831 21 110106443
Bundle branch block left 10.51 9.89 94 482741 12794 110093670
Paresis 10.49 9.89 4 482831 4840 110101624
Blood chloride decreased 10.49 9.89 72 482763 9043 110097421
Palatal oedema 10.44 9.89 23 482812 1677 110104787
Testicular failure 10.39 9.89 3 482832 5 110106459
Secondary hypertension 10.39 9.89 13 482822 590 110105874
Neuropathy peripheral 10.36 9.89 659 482176 178618 109927846
Tricuspid valve incompetence 10.35 9.89 154 482681 23719 110082745
Treatment noncompliance 10.29 9.89 403 482432 72587 110033877
Peripheral artery stenosis 10.29 9.89 20 482815 1334 110105130
Gastrointestinal vascular malformation 10.25 9.89 5 482830 52 110106412
Osmolar gap increased 10.25 9.89 8 482827 202 110106262
Disability assessment scale score increased 10.16 9.89 3 482832 4267 110102197
Throat tightness 10.16 9.89 204 482631 33285 110073179
Delayed graft function 10.12 9.89 3 482832 4254 110102210
Sinus bradycardia 10.11 9.89 183 482652 29300 110077164
Dry eye 10.07 9.89 177 482658 55616 110050848
Metastases to peritoneum 10.05 9.89 6 482829 5604 110100860
Haemolytic anaemia 10.05 9.89 52 482783 20868 110085596
Diabetic autonomic neuropathy 10.05 9.89 3 482832 6 110106458
Silent myocardial infarction 10.04 9.89 14 482821 707 110105757
Blindness transient 10.04 9.89 52 482783 5904 110100560
Pyelonephritis acute 10.02 9.89 10 482825 7203 110099261
Epiglottic oedema 9.99 9.89 11 482824 435 110106029
Transplant dysfunction 9.99 9.89 13 482822 8315 110098149
Protein total increased 9.96 9.89 44 482791 4680 110101784
Joint dislocation 9.95 9.89 207 482628 33983 110072481
Lung neoplasm malignant 9.94 9.89 97 482738 33745 110072719
Chills 9.93 9.89 707 482128 189873 109916591
Ludwig angina 9.92 9.89 9 482826 281 110106183

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C09AA03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
ATC C09BA03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and diuretics
ATC C09BB03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C10BX07 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
CHEBI has role CHEBI:35674 antihypertensive agent
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:35457 EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:55324 gastrointestinal drug
CHEBI has role CHEBI:145947 antiatherosclerotic agent

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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Myocardial infarction indication 22298006 DOID:5844
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Superficial Ocular Infection indication
Diabetic retinopathy off-label use 4855003 DOID:8947
Atrial fibrillation off-label use 49436004 DOID:0060224
Blepharoconjunctivitis off-label use 68659002 DOID:2456
Dacryocystitis off-label use 85777005 DOID:9938
Corneal ulcer off-label use 91514001 DOID:8463
Diabetic renal disease off-label use 127013003
Bacterial conjunctivitis off-label use 128350005 DOID:9700
Acute scleroderma renal crisis off-label use 236503001
Meibomianitis off-label use 309779001
Infective blepharitis off-label use 312219000
Bacterial keratitis off-label use 314557000
Diastolic heart failure off-label use 418304008 DOID:9775
Nondiabetic Proteinuric Nephropathy off-label use
Migraine Prevention off-label use
Anuria contraindication 2472002 DOID:2983
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Jaundice contraindication 18165001
Secondary angle-closure glaucoma contraindication 21571006
Hypovolemia contraindication 28560003
Acute cerebrovascular insufficiency contraindication 29322000
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Immunosuppression contraindication 38013005
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Aortic valve stenosis contraindication 60573004 DOID:1712
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Acute hepatic failure contraindication 197270009
Acute pancreatitis contraindication 197456007 DOID:2913
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Disorder of electrolytes contraindication 237840007
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Azotemia contraindication 445009001
Hemodialysis with High-Flux Membrane contraindication
Intestinal Angioedema contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.18 acidic
pKa2 3.18 acidic
pKa3 11.0 Basic
pKa4 6.95 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10039800 Nov. 6, 2035 ACUTE MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10039800 Nov. 6, 2035 METHOD OF TREATING HYPERTENSION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10039800 Nov. 6, 2035 METHOD OF TREATMENT OF HEART FAILURE
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10039800 Nov. 6, 2035 REDUCTION OF MORTALITY IN ACUTE MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10039800 Nov. 6, 2035 TREATMENT OF HEART FAILURE
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10039800 Nov. 6, 2035 TREATMENT OF HYPERTENSION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10039800 Nov. 6, 2035 TREATMENT OF MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10406199 Nov. 6, 2035 ACUTE MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10406199 Nov. 6, 2035 METHOD OF TREATING HYPERTENSION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10406199 Nov. 6, 2035 METHOD OF TREATMENT OF HEART FAILURE
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10406199 Nov. 6, 2035 REDUCTION OF MORTALITY IN ACUTE MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10406199 Nov. 6, 2035 TREATMENT OF HEART FAILURE
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10406199 Nov. 6, 2035 TREATMENT OF HYPERTENSION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 10406199 Nov. 6, 2035 TREATMENT OF MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 12433931 Nov. 6, 2035 TREATMENT OF HEART FAILURE
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 12433931 Nov. 6, 2035 TREATMENT OF HYPERTENSION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 12433931 Nov. 6, 2035 TREATMENT OF MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 9616096 Nov. 6, 2035 ACUTE MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 9616096 Nov. 6, 2035 METHOD OF TREATING HYPERTENSION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 9616096 Nov. 6, 2035 METHOD OF TREATMENT OF HEART FAILURE
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 9616096 Nov. 6, 2035 REDUCTION OF MORTALITY IN ACUTE MYOCARDIAL INFARCTION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 9616096 Nov. 6, 2035 TREATMENT OF HEART FAILURE
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 9616096 Nov. 6, 2035 TREATMENT OF HYPERTENSION
1MG/ML QBRELIS AZURITY N208401 July 29, 2016 RX SOLUTION ORAL 9616096 Nov. 6, 2035 TREATMENT OF MYOCARDIAL INFARCTION

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR IC50 8.92 WOMBAT-PK CHEMBL
Angiotensin-converting enzyme Enzyme Ki 7.29 CHEMBL

External reference:

IDSource
4019380 VUID
N0000147537 NUI
D00362 KEGG_DRUG
83915-83-7 SECONDARY_CAS_RN
4019380 VANDF
C0065374 UMLSCUI
CHEBI:6503 CHEBI
LPR PDB_CHEM_ID
CHEMBL419213 ChEMBL_ID
CHEMBL1729579 ChEMBL_ID
D017706 MESH_DESCRIPTOR_UI
DB00722 DRUGBANK_ID
5362119 PUBCHEM_CID
6360 IUPHAR_LIGAND_ID
E7199S1YWR UNII
29046 RXNORM
31907 MMSL
44066 MMSL
4985 MMSL
d00732 MMSL
000658 NDDF
108575001 SNOMEDCT_US
341000220102 SNOMEDCT_US
386873009 SNOMEDCT_US
E7199S1YWR INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0440-7674 TABLET 5 mg ORAL ANDA 21 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0405 TABLET 2.50 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0406 TABLET 5 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0407 TABLET 10 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0408 TABLET 20 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0409 TABLET 40 mg ORAL ANDA 26 sections
Lisinopril and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0591-0860 TABLET 10 mg ORAL ANDA 20 sections
Lisinopril and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0591-0861 TABLET 20 mg ORAL ANDA 20 sections
Lisinopril and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0591-0862 TABLET 20 mg ORAL ANDA 20 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0591-0885 TABLET 30 mg ORAL ANDA 26 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0615-8252 TABLET 2.50 mg ORAL ANDA 25 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0615-8253 TABLET 5 mg ORAL ANDA 25 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0615-8254 TABLET 10 mg ORAL ANDA 25 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0615-8255 TABLET 20 mg ORAL ANDA 25 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0615-8256 TABLET 40 mg ORAL ANDA 25 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0615-8405 TABLET 40 mg ORAL ANDA 25 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0615-8548 TABLET 30 mg ORAL ANDA 25 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0904-6797 TABLET 5 mg ORAL ANDA 25 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0904-6798 TABLET 10 mg ORAL ANDA 25 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0904-6799 TABLET 20 mg ORAL ANDA 25 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0904-6800 TABLET 40 mg ORAL ANDA 25 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 0904-7200 TABLET 40 mg ORAL ANDA 25 sections
Lisinopril and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10544-236 TABLET 10 mg ORAL ANDA 20 sections
Lisinopril and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10544-237 TABLET 20 mg ORAL ANDA 20 sections
LISINOPRIL HUMAN PRESCRIPTION DRUG LABEL 1 10544-238 TABLET 10 mg ORAL ANDA 24 sections
LISINOPRIL HUMAN PRESCRIPTION DRUG LABEL 1 10544-239 TABLET 20 mg ORAL ANDA 24 sections
LISINOPRIL HUMAN PRESCRIPTION DRUG LABEL 1 10544-240 TABLET 40 mg ORAL ANDA 24 sections
LISINOPRIL AND HYDROCHLOROTHIAZIDE HUMAN PRESCRIPTION DRUG LABEL 2 10544-564 TABLET 20 mg ORAL ANDA 25 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 10544-585 TABLET 5 mg ORAL ANDA 27 sections
Lisinopril HUMAN PRESCRIPTION DRUG LABEL 1 10544-623 TABLET 2.50 mg ORAL ANDA 27 sections