DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
moexipril 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
angiotensin-converting enzyme inhibitors
1827
103775-10-6
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
moexipril
moexipril hydrochloride
moclobenid
moexipril HCl
Molecular weight: 498.58
Formula: C27H34N2O7
CLOGP: 1.19
LIPINSKI: 0
HAC: 9
HDO: 2
TPSA: 114.40
ALOGS: -4.93
ROTB: 12
Status: OFP
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
Dose
Unit
Route
15
mg
O
ADMET properties:
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Property
Value
Reference
CL (Clearance)
6.30 mL/min/kg
Lombardo F, Berellini G, Obach RS
S (Water solubility)
32 mg/mL
Bocci G, Oprea TI, Benet LZ
BA (Bioavailability)
13 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
t_half (Half-life)
1.30 hours
Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)
1
Bocci G, Oprea TI, Benet LZ
fu (Fraction unbound in plasma)
0.12 %
Lombardo F, Berellini G, Obach RS
Showing 1 to 6 of 6 entries
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Approvals:
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Date
Agency
Company
Orphan
April 19, 1995
FDA
UCB INC
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
C09AA13
CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
ATC
C09BA13
CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and diuretics
FDA EPC
N0000175562
Angiotensin Converting Enzyme Inhibitor
FDA MoA
N0000000181
Angiotensin-converting Enzyme Inhibitors
MeSH PA
D000806
Angiotensin-Converting Enzyme Inhibitors
MeSH PA
D000959
Antihypertensive Agents
MeSH PA
D002317
Cardiovascular Agents
MeSH PA
D004791
Enzyme Inhibitors
MeSH PA
D011480
Protease Inhibitors
Showing 1 to 9 of 9 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Hypertensive disorder
indication
38341003
DOID:10763
Chronic heart failure
off-label use
48447003
Atrial fibrillation
off-label use
49436004
DOID:0060224
Diabetic renal disease
off-label use
127013003
Diastolic heart failure
off-label use
418304008
DOID:9775
Nondiabetic Proteinuric Nephropathy
off-label use
Anuria
contraindication
2472002
DOID:2983
Hypercholesterolemia
contraindication
13644009
Hyperkalemia
contraindication
14140009
Jaundice
contraindication
18165001
Showing 1 to 10 of 45 entries
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
3.08
acidic
pKa2
5.72
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Angiotensin-converting enzyme
Enzyme
P12821
ACE_HUMAN
INHIBITOR
IC50
8.59
CHEMBL
CHEMBL
Showing 1 to 1 of 1 entries
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External reference:
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entries
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ID
Source
005006
NDDF
005007
NDDF
103775-14-0
SECONDARY_CAS_RN
108566003
SNOMEDCT_US
108567007
SNOMEDCT_US
1546358
RXNORM
373442003
SNOMEDCT_US
4020925
VANDF
4023996
VUID
4023996
VANDF
Showing 1 to 10 of 34 entries
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Pharmaceutical products:
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Product
Category
Ingredients
NDC
Form
Quantity
Route
Marketing
Label
Moexipril Hydrochloride
HUMAN PRESCRIPTION DRUG LABEL
1
0093-0017
TABLET, FILM COATED
7.50 mg
ORAL
ANDA
25 sections
Moexipril Hydrochloride
HUMAN PRESCRIPTION DRUG LABEL
1
0093-5150
TABLET, FILM COATED
15 mg
ORAL
ANDA
25 sections
Moexipril Hydrochloride
HUMAN PRESCRIPTION DRUG LABEL
1
54868-4883
TABLET
15 mg
ORAL
ANDA
12 sections
Moexipril Hydrochloride
HUMAN PRESCRIPTION DRUG LABEL
1
54868-5928
TABLET
7.50 mg
ORAL
ANDA
12 sections
Moexipril Hydrochloride
HUMAN PRESCRIPTION DRUG LABEL
1
68151-1472
TABLET, FILM COATED
7.50 mg
ORAL
ANDA
25 sections
Moexipril Hydrochloride
HUMAN PRESCRIPTION DRUG LABEL
1
68151-1473
TABLET, FILM COATED
15 mg
ORAL
ANDA
25 sections
Moexipril Hydrochloride
HUMAN PRESCRIPTION DRUG LABEL
1
68462-208
TABLET, FILM COATED
15 mg
ORAL
ANDA
25 sections
Moexipril Hydrochloride
HUMAN PRESCRIPTION DRUG LABEL
1
68462-209
TABLET, FILM COATED
7.50 mg
ORAL
ANDA
25 sections
Univasc
HUMAN PRESCRIPTION DRUG LABEL
1
0091-3707
TABLET, FILM COATED
7.50 mg
ORAL
NDA
20 sections
Univasc
HUMAN PRESCRIPTION DRUG LABEL
1
0091-3715
TABLET, FILM COATED
15 mg
ORAL
NDA
20 sections
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moexipril