moexipril Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 1827 103775-10-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • moexipril
  • moexipril hydrochloride
  • moclobenid
  • moexipril HCl
  • Molecular weight: 498.58
  • Formula: C27H34N2O7
  • CLOGP: 1.39
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 2
  • TPSA: 114.40
  • ALOGS: -4.93
  • ROTB: 12

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
15 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 13 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance) 6.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 19, 1995 FDA UCB INC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C09AA13 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
ATC C09BA13 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and diuretics
FDA EPC N0000175562 Angiotensin Converting Enzyme Inhibitor
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure off-label use 48447003
Atrial fibrillation off-label use 49436004 DOID:0060224
Diabetic renal disease off-label use 127013003
Diastolic heart failure off-label use 418304008 DOID:9775
Nondiabetic Proteinuric Nephropathy off-label use
Anuria contraindication 2472002 DOID:2983
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Jaundice contraindication 18165001
Secondary angle-closure glaucoma contraindication 21571006
Acute vomiting contraindication 23971007
Hypovolemia contraindication 28560003
Acute cerebrovascular insufficiency contraindication 29322000
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Aortic valve stenosis contraindication 60573004 DOID:1712
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Severe diarrhea contraindication 409587002
Myocardial ischemia contraindication 414795007 DOID:3393
Azotemia contraindication 445009001
Hemodialysis with High-Flux Membrane contraindication
Intestinal Angioedema contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.08 acidic
pKa2 5.72 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR IC50 8.59 CHEMBL CHEMBL

External reference:

IDSource
4023996 VUID
N0000022001 NUI
C0066685 UMLSCUI
D00623 KEGG_DRUG
108566003 SNOMEDCT_US
4023996 VANDF
d03835 MMSL
30131 RXNORM
373442003 SNOMEDCT_US
005006 NDDF
CHEMBL1165 ChEMBL_ID
DB00691 DRUGBANK_ID
CHEMBL1200534 ChEMBL_ID
H3753190JS UNII
6946 INN_ID
103775-14-0 SECONDARY_CAS_RN
C059506 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:6960 CHEBI
CHEMBL1201405 ChEMBL_ID
91270 PUBCHEM_CID
6571 IUPHAR_LIGAND_ID
C058302 MESH_SUPPLEMENTAL_RECORD_UI
DB14210 DRUGBANK_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Univasc HUMAN PRESCRIPTION DRUG LABEL 1 0091-3707 TABLET, FILM COATED 7.50 mg ORAL NDA 13 sections
Univasc HUMAN PRESCRIPTION DRUG LABEL 1 0091-3715 TABLET, FILM COATED 15 mg ORAL NDA 13 sections
Moexipril Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0017 TABLET, FILM COATED 7.50 mg ORAL ANDA 12 sections
Moexipril Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-5150 TABLET, FILM COATED 15 mg ORAL ANDA 12 sections
Moexipril Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 54868-4883 TABLET 15 mg ORAL ANDA 12 sections
Moexipril Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 54868-5928 TABLET 7.50 mg ORAL ANDA 12 sections
Moexipril Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 68151-1472 TABLET, FILM COATED 7.50 mg ORAL ANDA 12 sections
Moexipril Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 68151-1473 TABLET, FILM COATED 15 mg ORAL ANDA 12 sections
Moexipril Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 68462-208 TABLET, FILM COATED 15 mg ORAL ANDA 13 sections
Moexipril Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 68462-209 TABLET, FILM COATED 7.50 mg ORAL ANDA 13 sections