Stem definition | Drug id | CAS RN |
---|---|---|
angiotensin-converting enzyme inhibitors | 2340 | 85441-61-8 |
Dose | Unit | Route |
---|---|---|
15 | mg | O |
15 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
S (Water solubility) | 0.00 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 3.10 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.61 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 19, 1991 | FDA | PFIZER PHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sedation complication | 1059.87 | 16.07 | 307 | 16470 | 13515 | 63458730 |
Orthostatic hypotension | 1029.54 | 16.07 | 379 | 16398 | 35781 | 63436464 |
Creatinine renal clearance decreased | 1026.90 | 16.07 | 311 | 16466 | 15997 | 63456248 |
Sedation | 952.85 | 16.07 | 365 | 16412 | 38444 | 63433801 |
Cognitive disorder | 876.65 | 16.07 | 381 | 16396 | 55434 | 63416811 |
Blood calcium decreased | 871.50 | 16.07 | 309 | 16468 | 26142 | 63446103 |
Balance disorder | 746.47 | 16.07 | 388 | 16389 | 84034 | 63388211 |
Depressed level of consciousness | 655.81 | 16.07 | 322 | 16455 | 61756 | 63410489 |
Constipation | 448.83 | 16.07 | 412 | 16365 | 224531 | 63247714 |
Mobility decreased | 428.14 | 16.07 | 310 | 16467 | 120849 | 63351396 |
Fall | 398.30 | 16.07 | 502 | 16275 | 391832 | 63080413 |
Hypotension | 380.23 | 16.07 | 411 | 16366 | 272193 | 63200052 |
Toxicity to various agents | 271.90 | 16.07 | 330 | 16447 | 246920 | 63225325 |
Cardiac failure congestive | 102.18 | 16.07 | 124 | 16653 | 92309 | 63379936 |
Hypertensive emergency | 97.63 | 16.07 | 31 | 16746 | 1851 | 63470394 |
Heart sounds | 89.13 | 16.07 | 25 | 16752 | 971 | 63471274 |
Prolonged expiration | 86.76 | 16.07 | 25 | 16752 | 1071 | 63471174 |
Myocardial infarction | 82.36 | 16.07 | 116 | 16661 | 99777 | 63372468 |
Pain | 80.73 | 16.07 | 397 | 16380 | 740231 | 62732014 |
Multiple drug therapy | 77.60 | 16.07 | 31 | 16746 | 3615 | 63468630 |
Coronary artery disease | 67.46 | 16.07 | 61 | 16716 | 32316 | 63439929 |
Cerebrovascular accident | 63.11 | 16.07 | 107 | 16670 | 107917 | 63364328 |
Drug ineffective | 62.94 | 16.07 | 113 | 16664 | 1044652 | 62427593 |
Depressive symptom | 57.72 | 16.07 | 26 | 16751 | 4076 | 63468169 |
Off label use | 56.69 | 16.07 | 57 | 16720 | 674405 | 62797840 |
Respiration abnormal | 46.69 | 16.07 | 26 | 16751 | 6391 | 63465854 |
Angina pectoris | 46.31 | 16.07 | 48 | 16729 | 30030 | 63442215 |
Appetite disorder | 43.51 | 16.07 | 26 | 16751 | 7295 | 63464950 |
Systemic lupus erythematosus | 38.27 | 16.07 | 5 | 16772 | 208913 | 63263332 |
Rash | 36.99 | 16.07 | 57 | 16720 | 560814 | 62911431 |
Therapeutic product effect decreased | 34.50 | 16.07 | 5 | 16772 | 193182 | 63279063 |
Sleep disorder due to a general medical condition | 33.65 | 16.07 | 27 | 16750 | 12161 | 63460084 |
Synovitis | 33 | 16.07 | 5 | 16772 | 186913 | 63285332 |
Flank pain | 32.38 | 16.07 | 30 | 16747 | 16380 | 63455865 |
Rales | 30.61 | 16.07 | 26 | 16751 | 12671 | 63459574 |
Arthropathy | 30.40 | 16.07 | 12 | 16765 | 234780 | 63237465 |
Alopecia | 30.05 | 16.07 | 27 | 16750 | 337509 | 63134736 |
Wound | 29.68 | 16.07 | 4 | 16773 | 163259 | 63308986 |
Discomfort | 28.38 | 16.07 | 5 | 16772 | 167369 | 63304876 |
Exposure during pregnancy | 27.83 | 16.07 | 4 | 16773 | 155543 | 63316702 |
Drug intolerance | 27.10 | 16.07 | 25 | 16752 | 308636 | 63163609 |
Glossodynia | 25.10 | 16.07 | 8 | 16769 | 178868 | 63293377 |
General physical health deterioration | 24.93 | 16.07 | 11 | 16766 | 201391 | 63270854 |
Product use issue | 24.37 | 16.07 | 14 | 16763 | 220506 | 63251739 |
Neutropenia | 24.25 | 16.07 | 8 | 16769 | 174997 | 63297248 |
Injury | 23.96 | 16.07 | 57 | 16720 | 73190 | 63399055 |
Hepatic enzyme increased | 23.59 | 16.07 | 12 | 16765 | 202316 | 63269929 |
Infection | 22.02 | 16.07 | 17 | 16760 | 229156 | 63243089 |
Infusion related reaction | 21.40 | 16.07 | 20 | 16757 | 245501 | 63226744 |
Joint swelling | 20.89 | 16.07 | 34 | 16743 | 327632 | 63144613 |
Product complaint | 20.72 | 16.07 | 21 | 16756 | 12788 | 63459457 |
Hypersensitivity | 19.97 | 16.07 | 29 | 16748 | 292656 | 63179589 |
Completed suicide | 19.59 | 16.07 | 7 | 16770 | 145666 | 63326579 |
Blood glucose increased | 19.09 | 16.07 | 57 | 16720 | 83699 | 63388546 |
Arthralgia | 18.87 | 16.07 | 82 | 16695 | 569628 | 62902617 |
Fear | 18.79 | 16.07 | 22 | 16755 | 15744 | 63456501 |
Fatigue | 18.67 | 16.07 | 148 | 16629 | 887880 | 62584365 |
Peripheral swelling | 18.48 | 16.07 | 26 | 16751 | 265916 | 63206329 |
Acute myocardial infarction | 17.66 | 16.07 | 31 | 16746 | 32093 | 63440152 |
Weight increased | 17.63 | 16.07 | 26 | 16751 | 260766 | 63211479 |
Angioedema | 17.53 | 16.07 | 39 | 16738 | 47926 | 63424319 |
Chest pain | 17.40 | 16.07 | 107 | 16670 | 215852 | 63256393 |
Abdominal discomfort | 17.18 | 16.07 | 37 | 16740 | 320848 | 63151397 |
Febrile neutropenia | 17.15 | 16.07 | 5 | 16772 | 118444 | 63353801 |
Coronary artery occlusion | 16.21 | 16.07 | 15 | 16762 | 8176 | 63464069 |
Pancytopenia | 16.20 | 16.07 | 3 | 16774 | 96930 | 63375315 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myocardial infarction | 124.30 | 14.59 | 157 | 9174 | 120928 | 34826672 |
Coronary artery disease | 118.14 | 14.59 | 100 | 9231 | 48205 | 34899395 |
Cardiac failure congestive | 101.71 | 14.59 | 118 | 9213 | 83152 | 34864448 |
Blood mercury abnormal | 101.26 | 14.59 | 21 | 9310 | 213 | 34947387 |
5-hydroxyindolacetic acid in urine increased | 99.30 | 14.59 | 21 | 9310 | 236 | 34947364 |
Low density lipoprotein decreased | 72.45 | 14.59 | 22 | 9309 | 1121 | 34946479 |
Expired product administered | 62.61 | 14.59 | 26 | 9305 | 3315 | 34944285 |
Head titubation | 58.89 | 14.59 | 15 | 9316 | 396 | 34947204 |
Hepatic neoplasm | 56.91 | 14.59 | 21 | 9310 | 1956 | 34945644 |
Blood glucose increased | 55.21 | 14.59 | 78 | 9253 | 66640 | 34880960 |
Acute myocardial infarction | 49.24 | 14.59 | 66 | 9265 | 53653 | 34893947 |
Cerebrovascular accident | 48.98 | 14.59 | 84 | 9247 | 84727 | 34862873 |
Arteriosclerosis coronary artery | 46.04 | 14.59 | 33 | 9298 | 12452 | 34935148 |
Glycosylated haemoglobin increased | 44.14 | 14.59 | 31 | 9300 | 11329 | 34936271 |
Off label use | 42.83 | 14.59 | 30 | 9301 | 419494 | 34528106 |
Cogwheel rigidity | 41.28 | 14.59 | 15 | 9316 | 1337 | 34946263 |
Hypertensive emergency | 41.18 | 14.59 | 14 | 9317 | 1026 | 34946574 |
Neoplasm | 39.17 | 14.59 | 22 | 9309 | 5445 | 34942155 |
Sedation complication | 30.52 | 14.59 | 13 | 9318 | 1764 | 34945836 |
Injury | 29.78 | 14.59 | 32 | 9299 | 20655 | 34926945 |
Coronary artery occlusion | 27.37 | 14.59 | 23 | 9308 | 10939 | 34936661 |
Neutropenia | 26.30 | 14.59 | 5 | 9326 | 156773 | 34790827 |
Angioedema | 25.57 | 14.59 | 40 | 9291 | 37334 | 34910266 |
Cardiac disorder | 25.23 | 14.59 | 43 | 9288 | 43083 | 34904517 |
General physical health deterioration | 23.99 | 14.59 | 3 | 9328 | 128266 | 34819334 |
Myocardial ischaemia | 23.44 | 14.59 | 26 | 9305 | 17382 | 34930218 |
Pseudohyponatraemia | 22.69 | 14.59 | 5 | 9326 | 69 | 34947531 |
Syncope | 21.22 | 14.59 | 63 | 9268 | 91388 | 34856212 |
Blood potassium decreased | 21.15 | 14.59 | 25 | 9306 | 17890 | 34929710 |
Hypoaesthesia | 21.09 | 14.59 | 49 | 9282 | 61395 | 34886205 |
Chest pain | 21.09 | 14.59 | 78 | 9253 | 126684 | 34820916 |
Bronchomalacia | 19.70 | 14.59 | 5 | 9326 | 130 | 34947470 |
Arrhythmia | 18.74 | 14.59 | 34 | 9297 | 35774 | 34911826 |
Extrapyramidal disorder | 18.67 | 14.59 | 20 | 9311 | 12860 | 34934740 |
Drug hypersensitivity | 18.23 | 14.59 | 55 | 9276 | 80474 | 34867126 |
Fibrous histiocytoma | 18.22 | 14.59 | 5 | 9326 | 177 | 34947423 |
Blood follicle stimulating hormone increased | 18.19 | 14.59 | 5 | 9326 | 178 | 34947422 |
Paralysis | 17.80 | 14.59 | 14 | 9317 | 6068 | 34941532 |
Coronary arterial stent insertion | 17.76 | 14.59 | 12 | 9319 | 4117 | 34943483 |
Anticholinergic syndrome | 17.64 | 14.59 | 8 | 9323 | 1261 | 34946339 |
Urticaria | 17.44 | 14.59 | 46 | 9285 | 62331 | 34885269 |
Haematocrit decreased | 17.38 | 14.59 | 31 | 9300 | 32185 | 34915415 |
Drug abuse | 16.95 | 14.59 | 3 | 9328 | 99093 | 34848507 |
Angina unstable | 16.72 | 14.59 | 18 | 9313 | 11635 | 34935965 |
Arteriosclerosis | 16.33 | 14.59 | 18 | 9313 | 11950 | 34935650 |
Nephropathy | 15.99 | 14.59 | 13 | 9318 | 5904 | 34941696 |
Rhabdomyolysis | 15.84 | 14.59 | 47 | 9284 | 68116 | 34879484 |
Pyrexia | 15.52 | 14.59 | 42 | 9289 | 332971 | 34614629 |
Angina pectoris | 15.43 | 14.59 | 29 | 9302 | 31334 | 34916266 |
Cardiopulmonary failure | 15.38 | 14.59 | 11 | 9320 | 4134 | 34943466 |
Ischaemic cardiomyopathy | 15.12 | 14.59 | 13 | 9318 | 6376 | 34941224 |
Febrile neutropenia | 14.96 | 14.59 | 9 | 9322 | 136840 | 34810760 |
Blood pressure systolic increased | 14.91 | 14.59 | 24 | 9307 | 22928 | 34924672 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sedation complication | 1100.37 | 13.97 | 330 | 22144 | 15339 | 79706575 |
Creatinine renal clearance decreased | 996.45 | 13.97 | 320 | 22154 | 18682 | 79703232 |
Orthostatic hypotension | 885.10 | 13.97 | 392 | 22082 | 55772 | 79666142 |
Sedation | 849.33 | 13.97 | 372 | 22102 | 51523 | 79670391 |
Blood calcium decreased | 845.82 | 13.97 | 323 | 22151 | 31496 | 79690418 |
Cognitive disorder | 803.01 | 13.97 | 392 | 22082 | 69534 | 79652380 |
Balance disorder | 691.31 | 13.97 | 398 | 22076 | 98459 | 79623455 |
Depressed level of consciousness | 522.46 | 13.97 | 330 | 22144 | 96322 | 79625592 |
Mobility decreased | 468.21 | 13.97 | 337 | 22137 | 121838 | 79600076 |
Constipation | 356.68 | 13.97 | 418 | 22056 | 282632 | 79439282 |
Fall | 331.77 | 13.97 | 534 | 21940 | 487095 | 79234819 |
Hypotension | 273.31 | 13.97 | 463 | 22011 | 439854 | 79282060 |
Cardiac failure congestive | 191.76 | 13.97 | 218 | 22256 | 142184 | 79579730 |
Myocardial infarction | 186.43 | 13.97 | 244 | 22230 | 183885 | 79538029 |
Coronary artery disease | 181.06 | 13.97 | 149 | 22325 | 65325 | 79656589 |
Toxicity to various agents | 153.66 | 13.97 | 355 | 22119 | 421185 | 79300729 |
Hypertensive emergency | 129.97 | 13.97 | 43 | 22431 | 2742 | 79719172 |
Pain | 119.26 | 13.97 | 451 | 22023 | 703351 | 79018563 |
Cerebrovascular accident | 103.44 | 13.97 | 169 | 22305 | 155123 | 79566791 |
Blood mercury abnormal | 100.11 | 13.97 | 21 | 22453 | 213 | 79721701 |
5-hydroxyindolacetic acid in urine increased | 97.98 | 13.97 | 21 | 22453 | 238 | 79721676 |
Off label use | 95.77 | 13.97 | 70 | 22404 | 907145 | 78814769 |
Heart sounds | 83.78 | 13.97 | 24 | 22450 | 942 | 79720972 |
Prolonged expiration | 77.28 | 13.97 | 24 | 22450 | 1247 | 79720667 |
Multiple drug therapy | 72.31 | 13.97 | 31 | 22443 | 4047 | 79717867 |
Low density lipoprotein decreased | 69.83 | 13.97 | 22 | 22452 | 1199 | 79720715 |
Acute myocardial infarction | 64.12 | 13.97 | 93 | 22381 | 76943 | 79644971 |
Drug ineffective | 56.40 | 13.97 | 140 | 22334 | 1080773 | 78641141 |
Angina pectoris | 54.47 | 13.97 | 70 | 22404 | 51662 | 79670252 |
Arteriosclerosis coronary artery | 52.26 | 13.97 | 42 | 22432 | 17774 | 79704140 |
Blood glucose increased | 52.15 | 13.97 | 106 | 22368 | 114869 | 79607045 |
Neutropenia | 48.22 | 13.97 | 11 | 22463 | 287699 | 79434215 |
Expired product administered | 48.08 | 13.97 | 28 | 22446 | 7023 | 79714891 |
Injury | 45.78 | 13.97 | 80 | 22394 | 77416 | 79644498 |
Hepatic neoplasm | 44.65 | 13.97 | 21 | 22453 | 3405 | 79718509 |
Depressive symptom | 42.46 | 13.97 | 25 | 22449 | 6398 | 79715516 |
Respiration abnormal | 40.48 | 13.97 | 26 | 22448 | 7762 | 79714152 |
General physical health deterioration | 39.69 | 13.97 | 14 | 22460 | 275224 | 79446690 |
Appetite disorder | 38.17 | 13.97 | 25 | 22449 | 7714 | 79714200 |
Coronary artery occlusion | 34.45 | 13.97 | 31 | 22443 | 15284 | 79706630 |
Angioedema | 33.17 | 13.97 | 69 | 22405 | 75966 | 79645948 |
Febrile neutropenia | 32.87 | 13.97 | 12 | 22462 | 230987 | 79490927 |
Therapeutic product effect decreased | 32.44 | 13.97 | 4 | 22470 | 163859 | 79558055 |
Rash | 32.35 | 13.97 | 72 | 22402 | 578286 | 79143628 |
Glycosylated haemoglobin increased | 32.01 | 13.97 | 33 | 22441 | 19227 | 79702687 |
Completed suicide | 31.38 | 13.97 | 15 | 22459 | 245752 | 79476162 |
Chest pain | 30.79 | 13.97 | 159 | 22315 | 282145 | 79439769 |
Product complaint | 29.99 | 13.97 | 27 | 22447 | 13322 | 79708592 |
Synovitis | 29.06 | 13.97 | 4 | 22470 | 150730 | 79571184 |
Infection | 29.00 | 13.97 | 16 | 22458 | 241696 | 79480218 |
Pancytopenia | 28.44 | 13.97 | 6 | 22468 | 165739 | 79556175 |
Flank pain | 27.70 | 13.97 | 31 | 22443 | 19813 | 79702101 |
Head titubation | 26.60 | 13.97 | 10 | 22464 | 928 | 79720986 |
Myocardial ischaemia | 26.02 | 13.97 | 34 | 22440 | 25485 | 79696429 |
Neoplasm | 25.70 | 13.97 | 21 | 22453 | 9095 | 79712819 |
Sleep disorder due to a general medical condition | 24.70 | 13.97 | 25 | 22449 | 14252 | 79707662 |
Arteriosclerosis | 24.63 | 13.97 | 28 | 22446 | 18199 | 79703715 |
Ischaemic cardiomyopathy | 24.41 | 13.97 | 19 | 22455 | 7676 | 79714238 |
Condition aggravated | 22.92 | 13.97 | 69 | 22405 | 501055 | 79220859 |
Wound | 22.59 | 13.97 | 3 | 22471 | 116176 | 79605738 |
Thrombocytopenia | 22.43 | 13.97 | 25 | 22449 | 265234 | 79456680 |
Product use issue | 22.26 | 13.97 | 16 | 22458 | 209806 | 79512108 |
Drug intolerance | 22.21 | 13.97 | 25 | 22449 | 264094 | 79457820 |
Angina unstable | 21.68 | 13.97 | 25 | 22449 | 16502 | 79705412 |
Pyrexia | 21.13 | 13.97 | 109 | 22365 | 678600 | 79043314 |
Hyperlipidaemia | 20.97 | 13.97 | 31 | 22443 | 26062 | 79695852 |
Stress | 20.51 | 13.97 | 59 | 22415 | 79553 | 79642361 |
Drug hypersensitivity | 20.30 | 13.97 | 149 | 22325 | 298767 | 79423147 |
Pericarditis | 19.55 | 13.97 | 3 | 22471 | 104233 | 79617681 |
Rales | 19.39 | 13.97 | 26 | 22448 | 19975 | 79701939 |
Pseudohyponatraemia | 19.36 | 13.97 | 5 | 22469 | 132 | 79721782 |
Alopecia | 19.34 | 13.97 | 22 | 22452 | 231333 | 79490581 |
Exposure during pregnancy | 18.76 | 13.97 | 3 | 22471 | 101129 | 79620785 |
Transient ischaemic attack | 18.66 | 13.97 | 44 | 22430 | 52651 | 79669263 |
Intentional product use issue | 18.34 | 13.97 | 10 | 22464 | 152102 | 79569812 |
Carotid artery stenosis | 18.28 | 13.97 | 17 | 22457 | 8741 | 79713173 |
Infusion related reaction | 18.07 | 13.97 | 23 | 22451 | 230214 | 79491700 |
Intentional overdose | 17.84 | 13.97 | 4 | 22470 | 105956 | 79615958 |
Fear | 17.49 | 13.97 | 26 | 22448 | 21960 | 79699954 |
Fatigue | 17.38 | 13.97 | 173 | 22301 | 929554 | 78792360 |
Product dose omission issue | 17.17 | 13.97 | 27 | 22447 | 247510 | 79474404 |
Emotional distress | 17.11 | 13.97 | 36 | 22438 | 39933 | 79681981 |
Arthropathy | 16.91 | 13.97 | 15 | 22459 | 177096 | 79544818 |
Blood potassium decreased | 16.65 | 13.97 | 39 | 22435 | 46473 | 79675441 |
Bronchomalacia | 15.88 | 13.97 | 5 | 22469 | 272 | 79721642 |
Pneumonia | 15.85 | 13.97 | 115 | 22359 | 660131 | 79061783 |
Discomfort | 15.52 | 13.97 | 8 | 22466 | 125609 | 79596305 |
Cardiac disorder | 15.29 | 13.97 | 47 | 22427 | 65710 | 79656204 |
Cogwheel rigidity | 15.29 | 13.97 | 10 | 22464 | 3078 | 79718836 |
Essential hypertension | 15.11 | 13.97 | 13 | 22461 | 6040 | 79715874 |
Decreased appetite | 15.03 | 13.97 | 48 | 22426 | 342370 | 79379544 |
Leukopenia | 15.03 | 13.97 | 7 | 22467 | 116506 | 79605408 |
Blood follicle stimulating hormone increased | 14.84 | 13.97 | 5 | 22469 | 337 | 79721577 |
Peripheral swelling | 14.68 | 13.97 | 34 | 22440 | 269583 | 79452331 |
Hepatic enzyme increased | 14.58 | 13.97 | 18 | 22456 | 182592 | 79539322 |
Joint swelling | 14.47 | 13.97 | 38 | 22436 | 288608 | 79433306 |
COVID-19 | 14.29 | 13.97 | 14 | 22460 | 157660 | 79564254 |
None
Source | Code | Description |
---|---|---|
ATC | C09AA06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain |
ATC | C09BA06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and diuretics |
FDA MoA | N0000000181 | Angiotensin-converting Enzyme Inhibitors |
FDA EPC | N0000175562 | Angiotensin Converting Enzyme Inhibitor |
MeSH PA | D000806 | Angiotensin-Converting Enzyme Inhibitors |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D011480 | Protease Inhibitors |
CHEBI has role | CHEBI:35457 | ACE inhibitor |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
CHEBI has role | CHEBI:50266 | Prodrugs |
CHEBI has role | CHEBI:35620 | vasodilator agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Chronic heart failure | indication | 48447003 | |
Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
Diabetic renal disease | off-label use | 127013003 | |
Acute scleroderma renal crisis | off-label use | 236503001 | |
Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
Nondiabetic Proteinuric Nephropathy | off-label use | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Hypercholesterolemia | contraindication | 13644009 | |
Hyperkalemia | contraindication | 14140009 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Hypovolemia | contraindication | 28560003 | |
Acute cerebrovascular insufficiency | contraindication | 29322000 | |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Immunosuppression | contraindication | 38013005 | |
Angioedema | contraindication | 41291007 | DOID:1558 |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
Hypomagnesemia | contraindication | 190855004 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Renal artery stenosis | contraindication | 302233006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Azotemia | contraindication | 445009001 | |
Hemodialysis with High-Flux Membrane | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.96 | acidic |
pKa2 | 5.72 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Angiotensin-converting enzyme | Enzyme | INHIBITOR | IC50 | 8.08 | CHEMBL | CHEMBL | |||
Angiotensin-converting enzyme | Enzyme | IC50 | 5.40 | DRUG MATRIX |
ID | Source |
---|---|
4020549 | VUID |
N0000148256 | NUI |
D00459 | KEGG_DRUG |
82586-55-8 | SECONDARY_CAS_RN |
4020379 | VANDF |
4020549 | VANDF |
C0072857 | UMLSCUI |
CHEBI:8713 | CHEBI |
CHEBI:140296 | CHEBI |
CHEMBL1592 | ChEMBL_ID |
CHEMBL1201011 | ChEMBL_ID |
D000077583 | MESH_DESCRIPTOR_UI |
DB00881 | DRUGBANK_ID |
6350 | IUPHAR_LIGAND_ID |
C054501 | MESH_SUPPLEMENTAL_RECORD_UI |
5780 | INN_ID |
RJ84Y44811 | UNII |
54892 | PUBCHEM_CID |
DB14217 | DRUGBANK_ID |
1546359 | RXNORM |
5401 | MMSL |
63990 | MMSL |
d00365 | MMSL |
003612 | NDDF |
003613 | NDDF |
108578004 | SNOMEDCT_US |
386874003 | SNOMEDCT_US |
386875002 | SNOMEDCT_US |
C0072858 | UMLSCUI |
CHEMBL1733 | ChEMBL_ID |
6356 | INN_ID |
82768-85-2 | SECONDARY_CAS_RN |
107994 | PUBCHEM_CID |
6352 | IUPHAR_LIGAND_ID |
34SSX5LDE5 | UNII |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-0220 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 22 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-0222 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 22 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-0223 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 22 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-0223 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 22 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0527 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0527 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0527 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0530 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0530 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0530 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0532 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0532 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0532 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0535 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0535 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0535 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-1205 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-1205 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-1205 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-1410 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-1410 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-1410 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-1620 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-1620 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-1620 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-1840 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-1840 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 25 sections |
Accupril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-1840 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 25 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-3112 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 22 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-3112 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 22 sections |