imidapril Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 1424 89371-37-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • imidapril hydrochloride
  • tanatril
  • imidapril
  • TA-6366
  • imidapril HCl
  • Molecular weight: 405.45
  • Formula: C20H27N3O6
  • CLOGP: 1.53
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 2
  • TPSA: 116.25
  • ALOGS: -2.96
  • ROTB: 10

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 5 % Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability) 20 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1993 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure 56.48 29.58 29 924 79919 46605190
Hepatic function abnormal 51.27 29.58 21 932 34400 46650709
Renal impairment 38.56 29.58 22 931 74350 46610759
Cerebral infarction 33.88 29.58 14 939 23352 46661757

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebral infarction 38.52 26.93 22 1697 26351 29924408
Interstitial lung disease 38.51 26.93 30 1689 60167 29890592
Cardiac failure 35.73 26.93 33 1686 83385 29867374
Altered state of consciousness 30.11 26.93 17 1702 19902 29930857
Hepatic function abnormal 27.00 26.93 21 1698 41924 29908835

Pharmacologic Action:

SourceCodeDescription
ATC C09AA16 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
CHEBI has role CHEBI:35457 ace inhibitor
CHEBI has role CHEBI:35674 antihypertensive
CHEBI has role CHEBI:50266 prodrugs
CHEBI has role CHEBI:49103 drug metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.49 acidic
pKa2 4.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR IC50 5 CHEMBL SCIENTIFIC LITERATURE

External reference:

IDSource
D01549 KEGG_DRUG
89396-94-1 SECONDARY_CAS_RN
89371-44-8 SECONDARY_CAS_RN
C0165703 UMLSCUI
C0246977 UMLSCUI
CHEBI:135654 CHEBI
CHEBI:141520 CHEBI
CHEMBL317094 ChEMBL_ID
DB11783 DRUGBANK_ID
CHEMBL99701 ChEMBL_ID
C065166 MESH_SUPPLEMENTAL_RECORD_UI
6377 IUPHAR_LIGAND_ID
C078006 MESH_SUPPLEMENTAL_RECORD_UI
6394 INN_ID
7209 INN_ID
BW7H1TJS22 UNII
WUU07Y30IA UNII
5464343 PUBCHEM_CID
5464344 PUBCHEM_CID
6378 IUPHAR_LIGAND_ID
259335 RXNORM
007791 NDDF
007792 NDDF
395741003 SNOMEDCT_US
395984005 SNOMEDCT_US
426163004 SNOMEDCT_US

Pharmaceutical products:

None