imidapril Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 1424 89371-37-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • imidapril hydrochloride
  • tanatril
  • imidapril
  • TA-6366
  • imidapril HCl
  • Molecular weight: 405.45
  • Formula: C20H27N3O6
  • CLOGP: 1.53
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 2
  • TPSA: 116.25
  • ALOGS: -2.96
  • ROTB: 10

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 5 % Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability) 20 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1993 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C09AA16 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35457 EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
CHEBI has role CHEBI:50266 prodrug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.49 acidic
pKa2 4.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR IC50 5 CHEMBL SCIENTIFIC LITERATURE

External reference:

IDSource
C0872994 UMLSCUI
D01549 KEGG_DRUG
7NSF9GG1NU UNII
89396-94-1 SECONDARY_CAS_RN
426163004 SNOMEDCT_US
007791 NDDF
60245 RXNORM
395984005 SNOMEDCT_US
6394 INN_ID
CHEMBL317094 ChEMBL_ID
CHEMBL99701 ChEMBL_ID
DB11783 DRUGBANK_ID
CHEBI:135654 CHEBI
5464343 PUBCHEM_CID
6377 IUPHAR_LIGAND_ID
C078006 MESH_SUPPLEMENTAL_RECORD_UI
C065166 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None