Stem definition | Drug id | CAS RN |
---|---|---|
angiotensin-converting enzyme inhibitors | 484 | 62571-86-2 |
Dose | Unit | Route |
---|---|---|
50 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 160 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 38 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 19.72 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 69 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.75 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 12 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.73 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
April 6, 1981 | FDA | PAR PHARM |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cardiac failure congestive | 69.11 | 13.80 | 91 | 9808 | 91659 | 46584504 |
Segmental diverticular colitis | 65.83 | 13.80 | 13 | 9886 | 130 | 46676033 |
Pedal pulse abnormal | 64.87 | 13.80 | 13 | 9886 | 141 | 46676022 |
Blood pressure abnormal | 64.04 | 13.80 | 37 | 9862 | 12180 | 46663983 |
Toxic epidermal necrolysis | 63.51 | 13.80 | 46 | 9853 | 22232 | 46653931 |
Calcium ionised decreased | 58.44 | 13.80 | 13 | 9886 | 240 | 46675923 |
Insulin autoimmune syndrome | 49.78 | 13.80 | 9 | 9890 | 53 | 46676110 |
Feeding intolerance | 49.38 | 13.80 | 13 | 9886 | 497 | 46675666 |
Occupational exposure to product | 48.68 | 13.80 | 17 | 9882 | 1704 | 46674459 |
Multiple organ dysfunction syndrome | 48.03 | 13.80 | 57 | 9842 | 51653 | 46624510 |
Cardiac failure | 40.79 | 13.80 | 66 | 9833 | 79882 | 46596281 |
Labile hypertension | 40.00 | 13.80 | 11 | 9888 | 497 | 46675666 |
Left ventricular hypertrophy | 37.04 | 13.80 | 19 | 9880 | 4944 | 46671219 |
Hypertension | 36.81 | 13.80 | 108 | 9791 | 196248 | 46479915 |
Myocardial infarction | 32.55 | 13.80 | 67 | 9832 | 97461 | 46578702 |
Haemodynamic instability | 31.70 | 13.80 | 20 | 9879 | 7705 | 46668458 |
Self-injurious ideation | 30.18 | 13.80 | 13 | 9886 | 2287 | 46673876 |
Metabolic acidosis | 29.98 | 13.80 | 39 | 9860 | 38741 | 46637422 |
Hypotension | 29.38 | 13.80 | 112 | 9787 | 232477 | 46443686 |
Dermatitis exfoliative | 29.12 | 13.80 | 17 | 9882 | 5699 | 46670464 |
Rheumatoid arthritis | 28.22 | 13.80 | 8 | 9891 | 240207 | 46435956 |
Gastrointestinal sounds abnormal | 24.95 | 13.80 | 13 | 9886 | 3493 | 46672670 |
Electrolyte imbalance | 24.86 | 13.80 | 24 | 9875 | 17202 | 46658961 |
Hyperthyroidism | 24.22 | 13.80 | 20 | 9879 | 11691 | 46664472 |
Cardiac failure acute | 23.74 | 13.80 | 17 | 9882 | 8061 | 46668102 |
Blood urea increased | 23.61 | 13.80 | 28 | 9871 | 25324 | 46650839 |
Hypertensive crisis | 23.58 | 13.80 | 21 | 9878 | 13594 | 46662569 |
Skin test positive | 23.53 | 13.80 | 8 | 9891 | 740 | 46675423 |
Acute myocardial infarction | 22.97 | 13.80 | 31 | 9868 | 31893 | 46644270 |
Vascular stent thrombosis | 22.34 | 13.80 | 8 | 9891 | 863 | 46675300 |
Renal failure | 20.78 | 13.80 | 62 | 9837 | 113532 | 46562631 |
Renal injury | 19.12 | 13.80 | 16 | 9883 | 9525 | 46666638 |
Stevens-Johnson syndrome | 18.90 | 13.80 | 24 | 9875 | 23273 | 46652890 |
Respiratory disorder | 18.87 | 13.80 | 26 | 9873 | 27274 | 46648889 |
Cholecystitis | 18.73 | 13.80 | 19 | 9880 | 14447 | 46661716 |
Hyperkalaemia | 18.29 | 13.80 | 36 | 9863 | 50673 | 46625490 |
Progressive supranuclear palsy | 18.24 | 13.80 | 4 | 9895 | 69 | 46676094 |
Acute kidney injury | 18.06 | 13.80 | 98 | 9801 | 235757 | 46440406 |
Posterior reversible encephalopathy syndrome | 18.01 | 13.80 | 19 | 9880 | 15122 | 46661041 |
Artery dissection | 17.45 | 13.80 | 4 | 9895 | 85 | 46676078 |
Drug interaction | 17.34 | 13.80 | 87 | 9812 | 203007 | 46473156 |
Circulatory collapse | 17.10 | 13.80 | 22 | 9877 | 21602 | 46654561 |
Nodal rhythm | 17.05 | 13.80 | 8 | 9891 | 1717 | 46674446 |
Renal impairment | 16.96 | 13.80 | 44 | 9855 | 74328 | 46601835 |
Extrasystoles | 16.06 | 13.80 | 11 | 9888 | 4858 | 46671305 |
Potentiating drug interaction | 15.70 | 13.80 | 10 | 9889 | 3913 | 46672250 |
Arthralgia | 15.47 | 13.80 | 34 | 9865 | 364569 | 46311594 |
Cyanosis | 15.47 | 13.80 | 18 | 9881 | 15953 | 46660210 |
Shock | 15.39 | 13.80 | 21 | 9878 | 21824 | 46654339 |
Blister | 15.27 | 13.80 | 31 | 9868 | 44600 | 46631563 |
Blood creatinine increased | 15.21 | 13.80 | 43 | 9856 | 76360 | 46599803 |
Bradycardia | 14.89 | 13.80 | 39 | 9860 | 66259 | 46609904 |
Coronary artery disease | 14.72 | 13.80 | 26 | 9873 | 33726 | 46642437 |
Cholelithiasis | 14.60 | 13.80 | 28 | 9871 | 38653 | 46637510 |
Product dose omission issue | 14.36 | 13.80 | 9 | 9890 | 168511 | 46507652 |
Restlessness | 14.28 | 13.80 | 22 | 9877 | 25502 | 46650661 |
Occupational dermatitis | 14.13 | 13.80 | 3 | 9896 | 44 | 46676119 |
Dehydration | 14.08 | 13.80 | 69 | 9830 | 159471 | 46516692 |
Fatigue | 14.06 | 13.80 | 74 | 9825 | 608623 | 46067540 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Blood ketone body increased | 36.54 | 14.49 | 10 | 7699 | 364 | 29944405 |
Scleroderma renal crisis | 31.93 | 14.49 | 7 | 7702 | 98 | 29944671 |
Cyanosis | 28.44 | 14.49 | 24 | 7685 | 11911 | 29932858 |
Cardiac failure congestive | 28.08 | 14.49 | 65 | 7644 | 84342 | 29860427 |
Angioedema | 27.75 | 14.49 | 39 | 7670 | 34345 | 29910424 |
Hypertensive crisis | 24.56 | 14.49 | 19 | 7690 | 8338 | 29936431 |
Kidney small | 23.01 | 14.49 | 5 | 7704 | 67 | 29944702 |
Renal failure | 21.97 | 14.49 | 78 | 7631 | 128888 | 29815881 |
Long QT syndrome | 21.60 | 14.49 | 11 | 7698 | 2322 | 29942447 |
Vitamin B12 deficiency | 20.45 | 14.49 | 11 | 7698 | 2594 | 29942175 |
Bladder sphincter atony | 19.72 | 14.49 | 3 | 7706 | 3 | 29944766 |
Myocardial infarction | 18.89 | 14.49 | 73 | 7636 | 125552 | 29819217 |
Indifference | 18.89 | 14.49 | 5 | 7704 | 160 | 29944609 |
Colitis microscopic | 18.64 | 14.49 | 9 | 7700 | 1694 | 29943075 |
Hypertension | 18.64 | 14.49 | 71 | 7638 | 121283 | 29823486 |
Pulmonary hypertensive crisis | 18.62 | 14.49 | 5 | 7704 | 169 | 29944600 |
Reaction to excipient | 18.56 | 14.49 | 6 | 7703 | 390 | 29944379 |
Coronary artery disease | 18.44 | 14.49 | 40 | 7669 | 49672 | 29895097 |
Cardiac failure | 18.28 | 14.49 | 55 | 7654 | 83363 | 29861406 |
Cerebrovascular accident | 18.26 | 14.49 | 55 | 7654 | 83422 | 29861347 |
Hypokalaemia | 18.18 | 14.49 | 40 | 7669 | 50152 | 29894617 |
Blood creatinine increased | 17.95 | 14.49 | 58 | 7651 | 91317 | 29853452 |
Renal failure neonatal | 16.81 | 14.49 | 4 | 7705 | 82 | 29944687 |
Haemorrhagic necrotic pancreatitis | 16.63 | 14.49 | 4 | 7705 | 86 | 29944683 |
Vascular resistance systemic decreased | 16.13 | 14.49 | 4 | 7705 | 98 | 29944671 |
Bronchospasm | 15.38 | 14.49 | 16 | 7693 | 10322 | 29934447 |
Orthopnoea | 14.84 | 14.49 | 11 | 7698 | 4529 | 29940240 |
Klebsiella infection | 14.68 | 14.49 | 13 | 7696 | 6874 | 29937895 |
Source | Code | Description |
---|---|---|
ATC | C09AA01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain |
ATC | C09BA01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and diuretics |
FDA MoA | N0000000181 | Angiotensin-converting Enzyme Inhibitors |
FDA EPC | N0000175562 | Angiotensin Converting Enzyme Inhibitor |
CHEBI has role | CHEBI:35457 | ace inhibitor |
CHEBI has role | CHEBI:35674 | antihypertensive |
MeSH PA | D000806 | Angiotensin-Converting Enzyme Inhibitors |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D011480 | Protease Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Chronic heart failure | indication | 48447003 | |
Diabetic renal disease | indication | 127013003 | |
Left ventricular cardiac dysfunction | indication | 429589006 | |
Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
Cystinuria | off-label use | 85020001 | DOID:9266 |
Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
Cystine Renal Calculi | off-label use | ||
Nondiabetic Proteinuric Nephropathy | off-label use | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Hypercholesterolemia | contraindication | 13644009 | |
Hyperkalemia | contraindication | 14140009 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Hypovolemia | contraindication | 28560003 | |
Acute cerebrovascular insufficiency | contraindication | 29322000 | |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Immunosuppression | contraindication | 38013005 | |
Angioedema | contraindication | 41291007 | DOID:1558 |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Cough | contraindication | 49727002 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Aortic valve stenosis | contraindication | 60573004 | DOID:1712 |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Transplantation | contraindication | 77465005 | |
Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
Hypomagnesemia | contraindication | 190855004 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Hypertrophic cardiomyopathy | contraindication | 233873004 | DOID:11984 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Renal artery stenosis | contraindication | 302233006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Azotemia | contraindication | 445009001 | |
Hemodialysis with High-Flux Membrane | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.85 | acidic |
pKa2 | 9.56 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Angiotensin-converting enzyme | Enzyme | INHIBITOR | Ki | 8.70 | WOMBAT-PK | CHEMBL | |||
Prothrombin | Enzyme | Ki | 7.32 | CHEMBL | |||||
Leukotriene A-4 hydrolase | Enzyme | IC50 | 7.15 | CHEMBL | |||||
Prostaglandin G/H synthase 1 | Enzyme | Ki | 4.77 | CHEMBL | |||||
Renin | Enzyme | Ki | 8.77 | CHEMBL | |||||
Prostaglandin G/H synthase 2 | Enzyme | Ki | 4.92 | CHEMBL | |||||
Beta-lactamase | Enzyme | Ki | 5.62 | CHEMBL | |||||
Angiotensin-converting enzyme | Enzyme | Ki | 8.77 | CHEMBL | |||||
Angiotensin-converting enzyme | Enzyme | Ki | 8.70 | CHEMBL | |||||
Succinyl-diaminopimelate desuccinylase | Enzyme | Ki | 5.74 | CHEMBL | |||||
Beta-lactamase II | Unclassified | Ki | 4.75 | CHEMBL | |||||
Beta-lactamase class B VIM-2 | Unclassified | Kd | 6.22 | CHEMBL |
ID | Source |
---|---|
4017614 | VUID |
N0000145994 | NUI |
D00251 | KEGG_DRUG |
4017614 | VANDF |
C0006938 | UMLSCUI |
CHEBI:3380 | CHEBI |
X8Z | PDB_CHEM_ID |
2550 | PUBCHEM_CID |
CHEMBL1560 | ChEMBL_ID |
DB01197 | DRUGBANK_ID |
D002216 | MESH_DESCRIPTOR_UI |
4373 | INN_ID |
5158 | IUPHAR_LIGAND_ID |
9G64RSX1XD | UNII |
1998 | RXNORM |
4347 | MMSL |
455 | MMSL |
d00006 | MMSL |
000656 | NDDF |
29439004 | SNOMEDCT_US |
387160004 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-1171 | TABLET | 12.50 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-1172 | TABLET | 25 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-1173 | TABLET | 50 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-1174 | TABLET | 100 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3007 | TABLET | 12.50 mg | ORAL | ANDA | 25 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3012 | TABLET | 25 mg | ORAL | ANDA | 25 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3017 | TABLET | 50 mg | ORAL | ANDA | 25 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3022 | TABLET | 100 mg | ORAL | ANDA | 25 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-4519 | TABLET | 12.50 mg | ORAL | ANDA | 21 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-4520 | TABLET | 25 mg | ORAL | ANDA | 21 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-4521 | TABLET | 50 mg | ORAL | ANDA | 21 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-8052 | TABLET | 12.50 mg | ORAL | ANDA | 16 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-8061 | TABLET | 25 mg | ORAL | ANDA | 16 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-8075 | TABLET | 50 mg | ORAL | ANDA | 16 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-8080 | TABLET | 100 mg | ORAL | ANDA | 16 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5045 | TABLET | 12.50 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5046 | TABLET | 25 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5047 | TABLET | 50 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7105 | TABLET | 12.50 mg | ORAL | ANDA | 12 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7106 | TABLET | 25 mg | ORAL | ANDA | 12 sections |
CAPTOPRIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-175 | TABLET | 50 mg | ORAL | ANDA | 19 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-477 | TABLET | 25 mg | ORAL | ANDA | 24 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-478 | TABLET | 50 mg | ORAL | ANDA | 24 sections |
Captopril | Human Prescription Drug Label | 1 | 27241-160 | TABLET | 12.50 mg | ORAL | ANDA | 12 sections |
Captopril | Human Prescription Drug Label | 1 | 27241-161 | TABLET | 25 mg | ORAL | ANDA | 12 sections |
Captopril | Human Prescription Drug Label | 1 | 27241-162 | TABLET | 50 mg | ORAL | ANDA | 12 sections |
Captopril | Human Prescription Drug Label | 1 | 27241-163 | TABLET | 100 mg | ORAL | ANDA | 12 sections |
CAPTOPRIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-182 | TABLET | 50 mg | ORAL | ANDA | 19 sections |
CAPTOPRIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-536 | TABLET | 100 mg | ORAL | ANDA | 19 sections |
CAPTOPRIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-974 | TABLET | 25 mg | ORAL | ANDA | 19 sections |