spirapril Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 2474 83647-97-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • spirapril
  • spirapril hydrochloride
  • renormax
  • spirapril HCl
  • Molecular weight: 466.61
  • Formula: C22H30N2O5S2
  • CLOGP: 1.05
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 95.94
  • ALOGS: -4.20
  • ROTB: 10

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
6 mg O

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.43 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 11.90 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1994 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C09AA11 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.99 acidic
pKa2 5.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR IC50 9.10 CHEMBL CHEMBL
Angiotensin-converting enzyme Enzyme IC50 7.17 CHEMBL

External reference:

IDSource
C0075007 UMLSCUI
D03765 KEGG_DRUG
36908 RXNORM
006843 NDDF
713473008 SNOMEDCT_US
96U2K78I3V UNII
6006 INN_ID
CHEMBL431 ChEMBL_ID
CHEMBL579 ChEMBL_ID
C076884 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL1200831 ChEMBL_ID
94841-17-5 SECONDARY_CAS_RN
DB01348 DRUGBANK_ID
5311447 PUBCHEM_CID
6575 IUPHAR_LIGAND_ID
C052555 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None