Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4360	8044-71-1

Description:

Molecule	Description
Synonyms: cetrimide cetavlon quammonium	Molecular weight: Formula: C4H11BrN(CH3)11,13,15 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

cetrimide
cetavlon
quammonium

Molecular weight:
Formula: C4H11BrN(CH3)11,13,15
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Muscle injury	239.93	69.39	242	19751	176412	90432042
Sleep disorder due to general medical condition, insomnia type	223.52	69.39	202	19791	128492	90479962
Irritable bowel syndrome	216.20	69.39	247	19746	207201	90401253
Folliculitis	176.18	69.39	221	19772	204132	90404322
Duodenal ulcer perforation	171.49	69.39	227	19766	221061	90387393
Lower respiratory tract infection	166.98	69.39	239	19754	250420	90358034
Anti-cyclic citrullinated peptide antibody positive	145.20	69.39	217	19776	236216	90372238
Helicobacter infection	144.76	69.39	212	19781	226638	90381816
Deep vein thrombosis postoperative	138.52	69.39	119	19874	70690	90537764
Impaired healing	133.97	69.39	208	19785	233991	90374463
Blister	128.81	69.39	214	19779	254784	90353670
Stomatitis	127.50	69.39	222	19771	274476	90333978
Lower limb fracture	127.36	69.39	123	19870	84890	90523564
Autoimmune disorder	120.58	69.39	114	19879	76630	90531824
Pericarditis	119.77	69.39	214	19779	269937	90338517
Gastrointestinal disorder	118.52	69.39	207	19786	256480	90351974
Ill-defined disorder	118.20	69.39	173	19820	184718	90423736
Sinusitis	115.67	69.39	242	19751	342846	90265608
Hand deformity	112.94	69.39	220	19773	296142	90312312
Contusion	111.34	69.39	199	19794	251017	90357437
Discomfort	111.10	69.39	209	19784	274126	90334328
C-reactive protein	110.77	69.39	75	19918	31292	90577162
Sciatica	107.59	69.39	122	19871	101260	90507194
Prescribed overdose	97.73	69.39	114	19879	97511	90510943
Injury	93.44	69.39	161	19832	197188	90411266
Infection	91.56	69.39	228	19765	361866	90246588
Nausea	89.31	69.39	69	19924	1110247	89498207
Glossodynia	88.16	69.39	209	19784	321570	90286884
Liver disorder	87.07	69.39	120	19873	121149	90487305
Nasopharyngitis	85.30	69.39	239	19754	406865	90201589
Pemphigus	84.92	69.39	208	19785	326656	90281798
Road traffic accident	84.12	69.39	111	19882	107515	90500939
Peripheral venous disease	79.02	69.39	95	19898	83826	90524628
Synovitis	78.50	69.39	203	19790	329549	90278905
Sleep disorder	77.78	69.39	149	19844	197881	90410573
Facet joint syndrome	77.70	69.39	102	19891	98287	90510167
Systemic lupus erythematosus	75.32	69.39	212	19781	361684	90246770
Confusional state	72.46	69.39	218	19775	385987	90222467
Contraindicated product administered	72.03	69.39	193	19800	319946	90288508
Hepatic enzyme increased	71.84	69.39	208	19785	360528	90247926
Joint range of motion decreased	71.28	69.39	116	19877	135527	90472927

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Muscle injury	262.59	103.17	201	17467	140606	110431025
Irritable bowel syndrome	243.60	103.17	205	17463	164010	110407621
Sleep disorder due to general medical condition, insomnia type	212.83	103.17	158	17510	105485	110466146
Duodenal ulcer perforation	194.62	103.17	187	17481	177513	110394118
Deep vein thrombosis postoperative	189.44	103.17	118	17550	59173	110512458
Folliculitis	184.66	103.17	177	17491	167476	110404155
Lower limb fracture	177.59	103.17	124	17544	75224	110496407
Anti-cyclic citrullinated peptide antibody positive	170.60	103.17	176	17492	181808	110389823
Autoimmune disorder	164.28	103.17	112	17556	65371	110506260
Lower respiratory tract infection	164.07	103.17	198	17470	242908	110328723
Helicobacter infection	159.93	103.17	170	17498	181707	110389924
Sciatica	152.87	103.17	123	17545	92276	110479355
Hand deformity	149.10	103.17	179	17489	218327	110353304
Impaired healing	137.23	103.17	163	17505	196554	110375077
C-reactive protein	135.44	103.17	75	17593	30256	110541375
Pericarditis	134.17	103.17	170	17498	218944	110352687
Sinusitis	133.12	103.17	198	17470	296490	110275141
Blister	132.30	103.17	172	17496	227204	110344427
Discomfort	132.13	103.17	167	17501	214540	110357091
Glossodynia	129.26	103.17	168	17500	221836	110349795
Prescribed overdose	126.96	103.17	108	17560	87473	110484158
Pemphigus	125.90	103.17	163	17505	214407	110357224
Stomatitis	116.41	103.17	177	17491	270065	110301566
Road traffic accident	111.78	103.17	110	17558	107288	110464343
Joint range of motion decreased	110.79	103.17	116	17552	121716	110449915
Gastrointestinal disorder	110.66	103.17	163	17505	241789	110329842
Systemic lupus erythematosus	110.13	103.17	167	17501	254171	110317460
Ill-defined disorder	106.10	103.17	128	17540	156725	110414906
Facet joint syndrome	106.07	103.17	102	17566	96726	110474905
Contusion	104.97	103.17	156	17512	233205	110338426
Peripheral venous disease	104.42	103.17	95	17573	84022	110487609

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D08AJ04	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quaternary ammonium compounds
ATC	D11AC01	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Medicated shampoos
CHEBI has role	CHEBI:73336	vulnerary
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local

Related Drugs by ATC class:

D08AJ Quaternary ammonium compounds 9 drugs

benzalkonium benzethonium benzoxonium chloride cetrimonium cetylpyridinium decamethoxine didecyldimethylammonium chloride dodeclonium bromide octenidine

D11AC Medicated shampoos 2 drugs

povidone-iodine xenysalate

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Dynamin-1	Structural	Q05193	DYN1_HUMAN		IC50	5.24		CHEMBL

External reference:

ID	Source
D02164	KEGG_DRUG
C0950191	UMLSCUI
CHEBI:3565	CHEBI
CHEMBL5219790	ChEMBL_ID
5157	INN_ID
24QSH2NL8N	UNII
288088	RXNORM
003518	NDDF
333179001	SNOMEDCT_US
395895003	SNOMEDCT_US
D000077286	MESH_DESCRIPTOR_UI
5974	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Derma Wound-Eaz	HUMAN OTC DRUG LABEL	1	82160-696	CREAM	5 mg	TOPICAL	unapproved drug other	15 sections

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cetrimide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: