riboflavin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2834 83-88-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • riboflavine
  • beflavine
  • lactoflavin
  • lactoflavine
  • Vitamin B2
  • riboflavin (vit B2)
  • riboflavin
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.
  • Molecular weight: 376.37
  • Formula: C17H20N4O6
  • CLOGP: -0.73
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 5
  • TPSA: 155.05
  • ALOGS: -2.76
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.09 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 75 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.33 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FGFR1,FLT1,FLT3,GRK2,GRK3,GSK3B,IGF1R,IKBKB,IRAK1,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K10,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM1,PIM2,PIM3,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,PTK2,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2,ZAP70 82
kinase-selectivity-class AXL,BRAF,CAMK2D,CDK16,CDK9,DYRK1A,EIF2AK3,GRK2,IRAK1,IRAK3,MAP2K6,MAP3K21,MAPK7,PDK1,PLK1,PLK4,PRKDC,PTK2,SIK2,STK33,TEK,ZAP70 22
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1698.13 9.88 6488 785787 320376 89515796
Systemic lupus erythematosus 1690.07 9.88 6947 785328 354949 89481223
Glossodynia 1445.38 9.88 6105 786170 315674 89520498
Hand deformity 1200.36 9.88 5452 786823 290910 89545262
Arthropathy 1163.91 9.88 6288 785987 359954 89476218
Abdominal discomfort 1061.89 9.88 7474 784801 469854 89366318
Alopecia 1045.96 9.88 7656 784619 487415 89348757
Wound 990.06 9.88 5243 787032 297737 89538435
Completed suicide 984.75 9.88 74 792201 144984 89691188
Toxicity to various agents 911.32 9.88 709 791566 287137 89549035
Synovitis 884.37 9.88 5413 786862 324339 89511833
Maternal exposure during pregnancy 835.29 9.88 5698 786577 354365 89481807
Pericarditis 818.93 9.88 4581 787694 265570 89570602
Swelling 817.53 9.88 6362 785913 412696 89423476
Anti-cyclic citrullinated peptide antibody positive 815.24 9.88 4154 788121 232279 89603893
Contraindicated product administered 729.07 9.88 5044 787231 315095 89521077
Discomfort 724.25 9.88 4486 787789 269849 89566323
Joint swelling 663.90 9.88 7020 785255 496280 89339892
Duodenal ulcer perforation 658.14 9.88 3734 788541 217554 89618618
Infusion related reaction 627.92 9.88 5976 786299 410804 89425368
Helicobacter infection 603.84 9.88 3718 788557 223132 89613040
Death 600.09 9.88 2017 790258 454534 89381638
Drug interaction 559.84 9.88 973 791302 275480 89560692
Intentional overdose 549.80 9.88 82 792193 93752 89742420
Rheumatoid arthritis 522.10 9.88 5151 787124 357463 89478709
Rheumatoid factor positive 482.50 9.88 2854 789421 168796 89667376
Pain 476.07 9.88 11725 780550 984616 88851556
Febrile neutropenia 455.65 9.88 427 791848 157922 89678250
Psoriatic arthropathy 449.02 9.88 3475 788800 224860 89611312
Hepatic enzyme increased 415.38 9.88 4901 787374 355835 89480337
Drug abuse 407.24 9.88 108 792167 82239 89753933
Therapeutic product effect decreased 377.56 9.88 3898 788377 273673 89562499
Suicide attempt 365.15 9.88 103 792172 75296 89760876
Musculoskeletal stiffness 361.47 9.88 4074 788201 292458 89543714
Disease progression 353.00 9.88 513 791762 156102 89680070
Arthralgia 352.09 9.88 9098 783177 769424 89066748
Impaired healing 350.97 9.88 3356 788919 230843 89605329
Malignant neoplasm progression 345.84 9.88 257 792018 106613 89729559
Product use issue 337.71 9.88 4385 787890 325534 89510638
Folliculitis 325.55 9.88 2967 789308 201386 89634786
Depressed level of consciousness 324.72 9.88 115 792160 72669 89763503
Constipation 323.14 9.88 1307 790968 279088 89557084
Acute kidney injury 321.85 9.88 1572 790703 318815 89517357
Neutropenia 310.71 9.88 971 791304 223933 89612239
Rheumatic fever 309.56 9.88 2346 789929 150775 89685397
Cardiac arrest 294.78 9.88 289 791986 104646 89731526
Blister 289.51 9.88 3456 788819 251542 89584630
Overdose 285.77 9.88 593 791682 157116 89679056
Drug intolerance 272.54 9.88 5457 786818 442134 89394038
Electrocardiogram QT prolonged 266.05 9.88 151 792124 72305 89763867
Muscle injury 265.82 9.88 2534 789741 174120 89662052
Sleep disorder due to general medical condition, insomnia type 249.09 9.88 1952 790323 126742 89709430
Irritable bowel syndrome 248.03 9.88 2840 789435 204608 89631564
Type 2 diabetes mellitus 243.69 9.88 2784 789491 200460 89635712
Swollen joint count increased 243.67 9.88 1737 790538 109469 89726703
Lactic acidosis 240.54 9.88 71 792204 50392 89785780
Fibromyalgia 239.08 9.88 2807 789468 203462 89632710
Hyperhidrosis 237.37 9.88 524 791751 135781 89700391
Nausea 234.91 9.88 7662 784613 1102654 88733518
Exposure during pregnancy 232.22 9.88 3141 789134 235269 89600903
Hypersensitivity 231.40 9.88 5402 786873 449275 89386897
Treatment failure 230.61 9.88 3836 788439 300092 89536080
Hypotension 225.25 9.88 1792 790483 323605 89512567
Somnolence 220.92 9.88 1007 791268 208077 89628095
Nasopharyngitis 220.91 9.88 4881 787394 402223 89433949
Hyponatraemia 219.13 9.88 530 791745 133008 89703164
Hip arthroplasty 217.10 9.88 1272 791003 74936 89761236
Sedation 215.06 9.88 76 792199 48095 89788077
Lower respiratory tract infection 213.64 9.88 3226 789049 247433 89588739
Knee arthroplasty 212.03 9.88 1349 790926 81833 89754339
Blood cholesterol increased 209.36 9.88 2757 789518 205255 89630917
C-reactive protein abnormal 207.32 9.88 1859 790416 125570 89710602
Cardiac failure 199.78 9.88 410 791865 109086 89727086
Ill-defined disorder 195.93 9.88 2474 789801 182417 89653755
Bradycardia 193.48 9.88 270 792005 83577 89752595
Stomatitis 179.08 9.88 3385 788890 271313 89564859
Liver injury 173.39 9.88 2265 790010 168302 89667870
Drug reaction with eosinophilia and systemic symptoms 172.06 9.88 79 792196 42679 89793493
Neoplasm progression 171.68 9.88 87 792188 44399 89791773
Agitation 171.47 9.88 200 792075 66898 89769274
Red blood cell sedimentation rate abnormal 170.15 9.88 532 791743 23672 89812500
Tremor 170.08 9.88 724 791551 152449 89683723
Renal failure 169.50 9.88 582 791693 130425 89705747
Contusion 169.41 9.88 3112 789163 248104 89588068
Anaemia 168.93 9.88 2123 790152 350679 89485493
Drug ineffective for unapproved indication 166.73 9.88 202 792073 66442 89769730
Myelosuppression 165.59 9.88 135 792140 53456 89782716
Diarrhoea 161.09 9.88 6646 785629 932544 88903628
Cognitive disorder 158.64 9.88 225 792050 69182 89766990
Serotonin syndrome 155.59 9.88 68 792207 37819 89798353
Osteoarthritis 154.48 9.88 2487 789788 193243 89642929
Renal impairment 154.22 9.88 443 791832 104978 89731194
Thrombocytopenia 153.98 9.88 1129 791146 207596 89628576
Rhabdomyolysis 153.60 9.88 133 792142 51123 89785049
Coma 150.17 9.88 252 792023 72380 89763792
Angioedema 145.63 9.88 213 792062 64663 89771509
Intentional product use issue 145.57 9.88 2685 789590 214207 89621965
Sopor 143.27 9.88 22 792253 24622 89811550
Hypoglycaemia 142.88 9.88 244 792031 69604 89766568
Neuropathy peripheral 142.07 9.88 664 791611 136306 89699866
Respiratory failure 140.71 9.88 545 791730 117873 89718299
Sickle cell anaemia with crisis 140.50 9.88 239 792036 7058 89829114
Chest discomfort 139.86 9.88 677 791598 137688 89698484
Syncope 138.26 9.88 642 791633 132021 89704151
Injury 134.14 9.88 2448 789827 194901 89641271
Respiratory arrest 133.33 9.88 62 792213 33249 89802923
Off label use 132.93 9.88 8089 784186 1094163 88742009
Myalgia 132.67 9.88 940 791335 174185 89661987
No adverse event 131.39 9.88 246 792029 67736 89768436
Intentional self-injury 128.03 9.88 48 792227 29286 89806886
Pregnancy 127.75 9.88 955 791320 61092 89775080
Weight increased 126.35 9.88 4653 787622 413274 89422898
Metabolic acidosis 125.75 9.88 182 792093 55494 89780678
Macular degeneration 123.21 9.88 91 792184 37879 89798293
Drug resistance 122.92 9.88 56 792219 30393 89805779
Joint range of motion decreased 122.22 9.88 1763 790512 133880 89702292
Facet joint syndrome 120.65 9.88 1354 790921 97035 89739137
Neutrophil count decreased 120.43 9.88 280 791995 71252 89764920
Hepatic function abnormal 120.41 9.88 136 792139 46152 89790020
Cytokine release syndrome 120.05 9.88 47 792228 27926 89808246
Grip strength decreased 119.95 9.88 1288 790987 91288 89744884
Cardio-respiratory arrest 118.95 9.88 232 792043 62908 89773264
Sinusitis 118.21 9.88 3878 788397 339210 89496962
Fatigue 117.93 9.88 11659 780616 1142364 88693808
Multiple organ dysfunction syndrome 117.88 9.88 264 792011 68072 89768100
General physical health deterioration 116.52 9.88 3991 788284 351124 89485048
Intentional product misuse 115.93 9.88 398 791877 89206 89746966
Inflammation 115.01 9.88 2197 790078 176395 89659777
Peripheral swelling 114.79 9.88 4557 787718 408549 89427623
Hyperglycaemia 113.76 9.88 168 792107 50802 89785370
Live birth 112.64 9.88 1122 791153 77985 89758187
Seizure 112.34 9.88 826 791449 151803 89684369
Vision blurred 111.83 9.88 539 791736 109754 89726418
Sedation complication 111.18 9.88 10 792265 16934 89819238
Orthostatic hypotension 110.88 9.88 121 792154 41706 89794466
Hepatic failure 110.87 9.88 110 792165 39618 89796554
COVID-19 110.70 9.88 943 791332 167900 89668272
Tachycardia 110.51 9.88 865 791410 156808 89679364
Palpitations 109.45 9.88 722 791553 136006 89700166
Blood glucose increased 108.93 9.88 445 791830 94801 89741371
White blood cell count decreased 108.81 9.88 935 791340 166174 89669998
Altered state of consciousness 108.37 9.88 71 792204 31461 89804711
Dyspnoea 108.30 9.88 6452 785823 874503 88961669
Balance disorder 107.66 9.88 459 791816 96621 89739551
Hypoxia 106.79 9.88 303 791972 72096 89764076
Dry skin 106.78 9.88 402 791873 87671 89748501
Device expulsion 105.40 9.88 121 792154 40765 89795407
Dysphagia 105.15 9.88 564 791711 111714 89724458
Rash 105.00 9.88 8197 784078 787903 89048269
Pulmonary fibrosis 103.58 9.88 1414 790861 106089 89730083
Accidental exposure to product 103.25 9.88 131 792144 42235 89793937
Mobility decreased 102.92 9.88 2896 789379 247838 89588334
Multiple sclerosis relapse 101.32 9.88 189 792086 52116 89784056
Dehydration 100.26 9.88 1151 791124 193296 89642876
Metastases to bone 99.74 9.88 49 792226 25456 89810716
Anaphylactic reaction 96.94 9.88 414 791861 87110 89749062
Deep vein thrombosis postoperative 96.35 9.88 995 791280 69814 89766358
Condition aggravated 95.66 9.88 6232 786043 589313 89246859
Platelet count decreased 95.25 9.88 753 791522 136216 89699956
Palmar-plantar erythrodysaesthesia syndrome 95.09 9.88 64 792211 27959 89808213
Erythema 93.69 9.88 1424 790851 227822 89608350
Blood pressure diastolic abnormal 93.45 9.88 383 791892 19498 89816674
Encephalopathy 93.38 9.88 164 792111 46280 89789892
Shock 93.34 9.88 69 792206 28709 89807463
Hepatocellular injury 93.19 9.88 70 792205 28888 89807284
Lip dry 92.46 9.88 1316 790959 99639 89736533
Blood pressure systolic abnormal 92.16 9.88 376 791899 19102 89817070
Anaphylactic shock 91.19 9.88 85 792190 31532 89804640
Drug withdrawal syndrome 90.43 9.88 71 792204 28652 89807520
Dysarthria 90.32 9.88 215 792060 54267 89781905
Temperature regulation disorder 89.51 9.88 11 792264 14568 89821604
Product dose omission issue 89.43 9.88 1906 790369 289781 89546391
Creatinine renal clearance decreased 89.32 9.88 27 792248 18872 89817300
Hyperkalaemia 89.25 9.88 281 791994 64683 89771489
Sepsis 88.99 9.88 1074 791201 178740 89657432
Infection 88.46 9.88 3941 788334 358153 89478019
Vomiting 88.17 9.88 5823 786452 782470 89053702
Restlessness 87.52 9.88 110 792165 35610 89800562
Skin exfoliation 86.94 9.88 303 791972 67610 89768562
Food allergy 86.71 9.88 58 792217 25420 89810752
Suicidal ideation 86.38 9.88 342 791933 73513 89762659
Feeling abnormal 85.40 9.88 992 791283 166243 89669929
Colitis 84.94 9.88 319 791956 69623 89766549
Obesity 84.83 9.88 1345 790930 104162 89732010
Hallucination 84.63 9.88 294 791981 65665 89770507
Wrong technique in product usage process 84.62 9.88 330 791945 71241 89764931
Asthenia 83.68 9.88 3813 788462 529938 89306234
Cardiac failure congestive 83.68 9.88 512 791763 98182 89737990
Leukopenia 82.02 9.88 529 791746 100181 89735991
Ejection fraction decreased 81.27 9.88 66 792209 26187 89809985
Cytomegalovirus infection 80.96 9.88 68 792207 26534 89809638
Drug dependence 80.92 9.88 82 792193 29245 89806927
Blood calcium decreased 80.35 9.88 87 792188 30095 89806077
Disability assessment scale score increased 80.01 9.88 132 792143 3799 89832373
Diabetic ketoacidosis 79.83 9.88 58 792217 24349 89811823
Rash erythematous 79.67 9.88 296 791979 64808 89771364
Ventricular tachycardia 79.16 9.88 60 792215 24648 89811524
Wound infection 79.09 9.88 1339 790936 105063 89731109
Back pain 78.93 9.88 2139 790136 315036 89521136
Cholestasis 77.78 9.88 123 792152 36176 89799996
Mydriasis 77.48 9.88 18 792257 14994 89821178
Autoimmune disorder 77.46 9.88 1018 791257 75726 89760446
Joint effusion 76.12 9.88 358 791917 19352 89816820
Anxiety 75.04 9.88 2097 790178 307675 89528497
Disturbance in attention 74.88 9.88 190 792085 46919 89789253
Schizophrenia 74.79 9.88 19 792256 14895 89821277
Metastases to liver 74.53 9.88 85 792190 28722 89807450
Cough 74.21 9.88 2560 789715 366402 89469770
Abortion spontaneous 74.21 9.88 761 791514 53295 89782877
Foot deformity 74.07 9.88 823 791452 58828 89777344
Myocardial infarction 73.02 9.88 584 791691 105388 89730784
Arthritis 73.00 9.88 1948 790327 165367 89670805
Hypercholesterolaemia 72.94 9.88 1264 791011 99628 89736544
Neurotoxicity 72.88 9.88 49 792226 21418 89814754
Drug level increased 72.83 9.88 81 792194 27681 89808491
C-reactive protein increased 72.71 9.88 2089 790186 179300 89656872
Personality disorder 72.59 9.88 11 792264 12433 89823739
Respiratory depression 72.26 9.88 23 792252 15552 89820620
Red blood cell sedimentation rate increased 71.41 9.88 1066 791209 81529 89754643
Sciatica 70.74 9.88 1263 791012 100119 89736053
Acute hepatic failure 70.74 9.88 56 792219 22505 89813667
Hypokalaemia 70.38 9.88 769 791506 130347 89705825
Flushing 69.94 9.88 469 791806 88022 89748150
Peripheral venous disease 69.43 9.88 1075 791200 82846 89753326
Blood pressure systolic increased 68.84 9.88 797 791478 57548 89778624
Blood pressure decreased 68.59 9.88 379 791896 74516 89761656
Gamma-glutamyltransferase increased 68.45 9.88 143 792132 37809 89798363
Gait inability 68.21 9.88 1720 790555 144736 89691436
Ascites 68.07 9.88 203 792072 47537 89788635
Product use in unapproved indication 67.82 9.88 2332 789943 333904 89502268
Disorientation 67.76 9.88 181 792094 43933 89792239
Blood creatine phosphokinase increased 67.62 9.88 121 792154 33902 89802270
Osteonecrosis of jaw 67.49 9.88 151 792124 38952 89797220
Extrapyramidal disorder 67.36 9.88 29 792246 16274 89819898
Blood creatinine increased 66.54 9.88 566 791709 100820 89735352
Device difficult to use 66.54 9.88 35 792240 17490 89818682
Foetal exposure during pregnancy 65.82 9.88 619 791656 42356 89793816
Cerebral haemorrhage 65.76 9.88 126 792149 34396 89801776
Blood bilirubin increased 65.54 9.88 180 792095 43290 89792882
Blood pressure fluctuation 65.01 9.88 723 791552 51690 89784482
Aphasia 64.75 9.88 177 792098 42635 89793537
Blood alkaline phosphatase increased 64.62 9.88 210 792065 47869 89788303
Torsade de pointes 64.34 9.88 26 792249 15156 89821016
Dermatitis atopic 64.34 9.88 66 792209 23406 89812766
Unresponsive to stimuli 64.34 9.88 149 792126 37972 89798200
Breast cancer stage III 63.96 9.88 1066 791209 83381 89752791
Metastases to central nervous system 63.75 9.88 37 792238 17505 89818667
Pulmonary embolism 63.33 9.88 785 791490 130035 89706137
Joint destruction 63.26 9.88 257 792018 13030 89823142
Musculoskeletal pain 63.15 9.88 1952 790323 169299 89666873
Poisoning 62.98 9.88 27 792248 15190 89820982
Gastrointestinal disorder 62.47 9.88 2793 789482 253894 89582278
Loss of consciousness 62.21 9.88 857 791418 139381 89696791
Disease recurrence 62.09 9.88 149 792126 37504 89798668
Adjustment disorder with depressed mood 62.01 9.88 764 791511 55989 89780183
Dislocation of vertebra 61.83 9.88 755 791520 55213 89780959
Fluid retention 61.83 9.88 483 791792 87608 89748564
Parkinsonism 61.41 9.88 23 792252 14042 89822130
Posterior reversible encephalopathy syndrome 61.02 9.88 63 792212 22276 89813896
Bursitis 60.67 9.88 1544 790731 130110 89706062
Emotional distress 60.51 9.88 145 792130 36517 89799655
Thrombotic microangiopathy 60.43 9.88 31 792244 15712 89820460
Therapy partial responder 60.40 9.88 62 792213 21981 89814191
Depressed mood 60.37 9.88 230 792045 49992 89786180
Hemiparesis 59.85 9.88 117 792158 31702 89804470
Juvenile idiopathic arthritis 59.75 9.88 117 792158 3860 89832312
Cerebrovascular accident 59.53 9.88 742 791533 122791 89713381
Exposure via skin contact 59.04 9.88 11 792264 10694 89825478
Bone pain 58.78 9.88 310 791965 61673 89774499
Road traffic accident 58.70 9.88 1292 790983 106334 89729838
Bone erosion 58.47 9.88 715 791560 52306 89783866
Atrial fibrillation 58.37 9.88 819 791456 132792 89703380
Akathisia 58.36 9.88 13 792262 11146 89825026
Hypothermia 57.83 9.88 32 792243 15543 89820629
Adverse event 57.67 9.88 1389 790886 116029 89720143
Mental status changes 57.41 9.88 199 792076 44480 89791692
Polyarthritis 57.32 9.88 314 791961 18036 89818136
Dizziness 57.27 9.88 4405 787870 584879 89251293
Exposure to toxic agent 57.22 9.88 3 792272 7964 89828208
Chronic kidney disease 57.07 9.88 235 792040 49956 89786216
Angina pectoris 56.93 9.88 165 792110 38995 89797177
Psychotic disorder 56.89 9.88 117 792158 31113 89805059
Withdrawal syndrome 56.62 9.88 68 792207 22456 89813716
Hypomania 56.41 9.88 6 792269 8891 89827281
Disseminated intravascular coagulation 56.32 9.88 63 792212 21475 89814697
Dysgeusia 56.14 9.88 252 792023 52308 89783864
Hemiplegia 56.06 9.88 36 792239 16124 89820048
Vertigo 55.67 9.88 369 791906 69442 89766730
Eating disorder 55.65 9.88 100 792175 27973 89808199
Carotid artery thrombosis 55.48 9.88 7 792268 9085 89827087
Hypomagnesaemia 54.67 9.88 146 792129 35442 89800730
Polyneuropathy 54.60 9.88 53 792222 19288 89816884
Chronic sinusitis 54.54 9.88 77 792198 23725 89812447
Aspartate aminotransferase increased 54.33 9.88 606 791669 102331 89733841
Skin haemorrhage 54.32 9.88 64 792211 21316 89814856
Nasal polyps 54.29 9.88 14 792261 10866 89825306
Pulmonary oedema 54.23 9.88 319 791956 61761 89774411
Procedural pain 54.23 9.88 133 792142 33227 89802945
Respiratory distress 53.82 9.88 168 792107 38778 89797394
Pain in jaw 53.73 9.88 226 792049 47759 89788413
Inappropriate antidiuretic hormone secretion 53.29 9.88 55 792220 19450 89816722
Hepatotoxicity 53.15 9.88 213 792062 45629 89790543
Dyskinesia 53.07 9.88 154 792121 36380 89799792
Pancreatitis acute 53.02 9.88 127 792148 31988 89804184
Swollen tongue 52.98 9.88 214 792061 45742 89790430
Alanine aminotransferase increased 51.83 9.88 725 791550 117613 89718559
Joint laxity 51.82 9.88 87 792188 2541 89833631
Basal cell carcinoma 51.67 9.88 482 791793 32907 89803265
Prescribed underdose 51.42 9.88 932 791343 74087 89762085
Speech disorder 50.85 9.88 215 792060 45370 89790802
Proteinuria 50.78 9.88 78 792197 23213 89812959
Second primary malignancy 50.57 9.88 14 792261 10364 89825808
Joint stiffness 50.52 9.88 961 791314 77081 89759091
Arrhythmia 50.15 9.88 195 792080 42137 89794035
Acute respiratory failure 50.02 9.88 199 792076 42719 89793453
Brain oedema 49.83 9.88 47 792228 17338 89818834
Toxic skin eruption 49.65 9.88 39 792236 15735 89820437
Bronchospasm 49.47 9.88 65 792210 20644 89815528
Sleep disorder 49.32 9.88 2160 790115 195870 89640302
Haematotoxicity 49.14 9.88 24 792251 12511 89823661
Abnormal behaviour 49.12 9.88 76 792199 22552 89813620
Gestational diabetes 49.06 9.88 203 792072 10379 89825793
Lower limb fracture 48.75 9.88 1028 791247 83985 89752187
Stevens-Johnson syndrome 48.63 9.88 116 792159 29260 89806912
Eczema 48.16 9.88 268 792007 52602 89783570
Face oedema 48.10 9.88 81 792194 23237 89812935
Miosis 47.72 9.88 12 792263 9472 89826700
Status epilepticus 47.42 9.88 57 792218 18817 89817355
Diabetes mellitus inadequate control 47.40 9.88 56 792219 18628 89817544
Coordination abnormal 47.06 9.88 71 792204 21285 89814887
Muscle spasticity 46.97 9.88 155 792120 35167 89801005
Acute generalised exanthematous pustulosis 46.89 9.88 31 792244 13672 89822500
Headache 46.85 9.88 6721 785554 856025 88980147
Gastrointestinal haemorrhage 46.57 9.88 534 791741 89714 89746458
Lethargy 46.29 9.88 342 791933 62797 89773375
Myoclonus 45.95 9.88 60 792215 19108 89817064
Paraesthesia oral 45.58 9.88 134 792141 31525 89804647
Caesarean section 45.31 9.88 298 791977 18279 89817893
Aggression 45.19 9.88 104 792171 26564 89809608
Adjustment disorder 45.16 9.88 14 792261 9628 89826544
Dry mouth 45.03 9.88 2004 790271 182055 89654117
Pleural effusion 44.92 9.88 698 791577 111293 89724879
Muscle twitching 44.66 9.88 90 792185 24112 89812060
Eye pruritus 44.65 9.88 119 792156 28908 89807264
Cytopenia 44.58 9.88 52 792223 17397 89818775
Loss of personal independence in daily activities 44.38 9.88 1529 790746 134576 89701596
Haemorrhage 44.30 9.88 390 791885 68979 89767193
Dystonia 44.20 9.88 49 792226 16770 89819402
Drug tolerance decreased 43.94 9.88 452 791823 31678 89804494
Injection site reaction 43.93 9.88 1085 791190 90995 89745177
Affect lability 43.86 9.88 56 792219 18007 89818165
Ventricular fibrillation 43.85 9.88 35 792240 14009 89822163
Osteoporosis 43.85 9.88 1130 791145 95401 89740771
Metastases to lung 43.79 9.88 45 792230 15946 89820226
C-reactive protein 43.72 9.88 443 791832 30924 89805248
Rebound effect 43.29 9.88 14 792261 9370 89826802
Psoriasis 43.08 9.88 1639 790636 146115 89690057
Irritability 43.07 9.88 163 792112 35499 89800673
Arterial occlusive disease 42.80 9.88 28 792247 12418 89823754
Myocarditis 42.37 9.88 35 792240 13771 89822401
Transplant rejection 42.14 9.88 30 792245 12728 89823444
Coagulopathy 41.79 9.88 88 792187 23201 89812971
Haemophagocytic lymphohistiocytosis 41.77 9.88 44 792231 15415 89820757
Eosinophilia 41.64 9.88 120 792155 28413 89807759
Bronchopulmonary aspergillosis 41.48 9.88 24 792251 11374 89824798
Multiple drug therapy 41.33 9.88 6 792269 7003 89829169
Anti-cyclic citrullinated peptide antibody 41.14 9.88 391 791884 26830 89809342
Sinus tachycardia 40.82 9.88 121 792154 28392 89807780
Rhinitis allergic 40.80 9.88 52 792223 16733 89819439
Hypothyroidism 40.77 9.88 284 791991 52843 89783329
Mania 40.70 9.88 38 792237 14086 89822086
Premature labour 40.52 9.88 227 792048 13149 89823023
Tachypnoea 40.39 9.88 78 792197 21231 89814941
Cerebral infarction 40.19 9.88 110 792165 26486 89809686
Fall 40.06 9.88 3646 788629 478164 89358008
Illness 39.99 9.88 491 791784 81478 89754694
Tardive dyskinesia 39.80 9.88 23 792252 10907 89825265
Atrioventricular block complete 39.67 9.88 18 792257 9793 89826379
X-ray abnormal 39.55 9.88 587 791688 44837 89791335
Motor dysfunction 39.48 9.88 67 792208 19163 89817009
Chills 39.37 9.88 866 791409 131115 89705057
Forced expiratory volume decreased 39.29 9.88 3 792272 5805 89830367
Small for dates baby 38.90 9.88 114 792161 4893 89831279
Oedema 38.83 9.88 2132 790143 198163 89638009
Acute myeloid leukaemia 38.73 9.88 76 792199 20564 89815608
Lymphocyte count decreased 38.67 9.88 166 792109 34884 89801288
Blood pressure diastolic decreased 38.42 9.88 381 791894 26445 89809727
Stress cardiomyopathy 38.40 9.88 36 792239 13319 89822853
Nightmare 38.22 9.88 83 792192 21642 89814530
Deep vein thrombosis 38.12 9.88 567 791708 91053 89745119
Disability 38.04 9.88 533 791742 40212 89795960
Drug dose omission by device 38.01 9.88 21 792254 10210 89825962
Graft versus host disease 37.83 9.88 12 792263 8132 89828040
Asphyxia 37.70 9.88 8 792267 7095 89829077
Vaginal flatulence 37.61 9.88 33 792242 12605 89823567
Laryngitis 37.45 9.88 638 791637 50115 89786057
Neck deformity 37.36 9.88 68 792207 2121 89834051
Abdominal pain 37.30 9.88 2965 789310 392756 89443416
Muscle rigidity 37.26 9.88 42 792233 14267 89821905
Nodule 37.25 9.88 377 791898 26309 89809863
Hospitalisation 37.22 9.88 844 791431 127256 89708916
Cardiogenic shock 37.12 9.88 101 792174 24367 89811805
Clostridium difficile colitis 37.04 9.88 115 792160 26591 89809581
Mental disorder 36.94 9.88 151 792124 32167 89804005
Obstructive airways disorder 36.88 9.88 110 792165 25759 89810413
Haemorrhage intracranial 36.82 9.88 47 792228 15115 89821057
Lupus-like syndrome 36.76 9.88 616 791659 48230 89787942
Hypoaesthesia 36.54 9.88 3206 789069 311004 89525168
Melaena 36.47 9.88 168 792107 34629 89801543
Pain in extremity 36.46 9.88 4485 787790 446044 89390128
Neuroleptic malignant syndrome 36.45 9.88 47 792228 15049 89821123
Proctitis 36.34 9.88 48 792227 15211 89820961
Paradoxical drug reaction 36.27 9.88 4 792271 5762 89830410
Onychomycosis 35.73 9.88 491 791784 36885 89799287
Joint dislocation 35.69 9.88 568 791707 44014 89792158
Haematoma 35.53 9.88 198 792077 38850 89797322
Pulmonary arterial hypertension 35.45 9.88 114 792161 26073 89810099
Paralysis 35.35 9.88 29 792246 11449 89824723
International normalised ratio increased 35.30 9.88 255 792020 47061 89789111
Hallucination, visual 35.27 9.88 95 792180 22997 89813175
Jaundice 35.27 9.88 155 792120 32362 89803810
Mucosal inflammation 35.04 9.88 328 791947 57297 89778875
Aspergillus infection 35.03 9.88 26 792249 10797 89825375
Diabetes mellitus 35.00 9.88 380 791895 64495 89771677
Hepatic cytolysis 34.99 9.88 145 792130 30771 89805401
Tinnitus 34.78 9.88 227 792048 42875 89793297
Device use error 34.70 9.88 10 792265 7211 89828961
Onychomadesis 34.58 9.88 580 791695 45418 89790754
Tumour lysis syndrome 34.56 9.88 28 792247 11124 89825048
Gangrene 34.40 9.88 37 792238 12839 89823333
Sensory loss 34.40 9.88 66 792209 18009 89818163
Tuberculosis 34.14 9.88 207 792068 12342 89823830
Urinary retention 34.01 9.88 192 792083 37552 89798620
Epistaxis 33.98 9.88 531 791744 84594 89751578
Acute graft versus host disease 33.88 9.88 4 792271 5464 89830708
Haemoptysis 33.67 9.88 163 792112 33157 89803015
Lung disorder 33.66 9.88 1618 790657 148265 89687907
Lupus vulgaris 33.45 9.88 567 791708 44492 89791680
Substance abuse 33.38 9.88 4 792271 5402 89830770
Pseudomonas infection 33.16 9.88 49 792226 14816 89821356
Device related infection 33.03 9.88 115 792160 25671 89810501
Panic attack 32.83 9.88 119 792156 26246 89809926
Female genital tract fistula 32.50 9.88 67 792208 17801 89818371
Cardiotoxicity 32.40 9.88 31 792244 11358 89824814
Lip swelling 32.35 9.88 201 792074 38409 89797763
Bradyphrenia 32.32 9.88 13 792262 7599 89828573
Dyspnoea exertional 32.31 9.88 441 791834 71847 89764325
Rheumatoid nodule 32.15 9.88 293 791982 19873 89816299
Epstein-Barr virus infection 32.02 9.88 26 792249 10318 89825854
Wheelchair user 31.98 9.88 144 792131 7641 89828531
Circulatory collapse 31.94 9.88 111 792164 24793 89811379
Multiple-drug resistance 31.86 9.88 14 792261 7762 89828410
Erythema multiforme 31.82 9.88 36 792239 12210 89823962
Ischaemic stroke 31.78 9.88 94 792181 22072 89814100
Acute respiratory distress syndrome 31.56 9.88 136 792139 28550 89807622
Multiple fractures 31.48 9.88 166 792109 9396 89826776
Maternal drugs affecting foetus 31.46 9.88 108 792167 5047 89831125
Heart rate decreased 31.32 9.88 649 791626 52856 89783316
Swelling face 31.29 9.88 511 791764 80841 89755331
Maternal exposure before pregnancy 31.17 9.88 186 792089 11027 89825145
Dysuria 31.04 9.88 209 792066 39192 89796980
Cardiomyopathy 30.96 9.88 83 792192 20123 89816049
Exostosis 30.94 9.88 644 791631 52490 89783682
Psychomotor hyperactivity 30.83 9.88 40 792235 12773 89823399
Acute graft versus host disease in skin 30.69 9.88 3 792272 4753 89831419
Hepatic cirrhosis 30.67 9.88 747 791528 62506 89773666
Accidental overdose 30.53 9.88 135 792140 28138 89808034
Retinitis 30.42 9.88 489 791786 37969 89798203
Nervousness 30.27 9.88 174 792101 33882 89802290
Pericardial effusion 30.22 9.88 193 792082 36640 89799532
Ventricular septal defect 30.18 9.88 110 792165 5297 89830875
Complication of device insertion 30.16 9.88 28 792247 10408 89825764
Jaundice cholestatic 30.16 9.88 26 792249 10017 89826155
Haematochezia 30.14 9.88 437 791838 70476 89765696
Pyrexia 29.94 9.88 5198 787077 655287 89180885
Tenderness 29.91 9.88 363 791912 26505 89809667
Radiculopathy 29.90 9.88 74 792201 18431 89817741
Skin burning sensation 29.71 9.88 81 792194 19530 89816642
Interstitial lung disease 29.69 9.88 479 791796 75926 89760246
Febrile bone marrow aplasia 29.50 9.88 25 792250 9713 89826459
Glycosylated haemoglobin increased 29.46 9.88 57 792218 15505 89820667
Complication of device removal 29.44 9.88 9 792266 6246 89829926
Rash maculo-papular 29.39 9.88 223 792052 40710 89795462
Leukocytosis 29.38 9.88 155 792120 30835 89805337
Lymphopenia 29.34 9.88 102 792173 22779 89813393
Product administration error 29.24 9.88 125 792150 26298 89809874
Product preparation error 29.10 9.88 28 792247 10233 89825939
Vascular device infection 29.08 9.88 37 792238 11915 89824257
Fear 28.84 9.88 64 792211 16558 89819614
Infusion site pain 28.81 9.88 83 792192 19655 89816517
Drug hypersensitivity 28.62 9.88 3582 788693 460027 89376145
Crying 28.58 9.88 121 792154 25524 89810648
Blood pressure diastolic increased 28.48 9.88 202 792073 12704 89823468
Device dislocation 28.44 9.88 160 792115 31322 89804850
Inappropriate schedule of product administration 28.33 9.88 1048 791227 148885 89687287
Sleep apnoea syndrome 28.33 9.88 162 792113 31585 89804587
Ketoacidosis 28.30 9.88 7 792268 5588 89830584
Vaginal discharge 28.30 9.88 82 792193 19382 89816790
Pathogen resistance 28.26 9.88 18 792257 8097 89828075
Genital haemorrhage 28.04 9.88 21 792254 8681 89827491
Premature rupture of membranes 27.66 9.88 109 792166 5449 89830723
Hypophagia 27.63 9.88 192 792083 35745 89800427
Pulmonary hypertension 27.62 9.88 238 792037 42285 89793887
Influenza like illness 27.59 9.88 517 791758 80094 89756078
Product prescribing issue 27.37 9.88 18 792257 7961 89828211
Product prescribing error 27.35 9.88 153 792122 29992 89806180
Blood urea increased 27.24 9.88 155 792120 30258 89805914
Sinus disorder 27.00 9.88 183 792092 34264 89801908
Infective pulmonary exacerbation of cystic fibrosis 26.95 9.88 30 792245 10249 89825923
Hot flush 26.92 9.88 362 791913 59126 89777046
Eye irritation 26.88 9.88 180 792095 33798 89802374
Urinary incontinence 26.81 9.88 205 792070 37361 89798811
Delusion 26.81 9.88 50 792225 13790 89822382
Wheezing 26.70 9.88 2423 789852 235657 89600515
Ankylosing spondylitis 26.38 9.88 201 792074 12932 89823240
Pemphigoid 26.34 9.88 24 792251 9002 89827170
Cytomegalovirus infection reactivation 26.22 9.88 18 792257 7782 89828390
Transaminases increased 26.06 9.88 204 792071 36988 89799184
Aspiration 25.95 9.88 62 792213 15631 89820541
Body temperature decreased 25.75 9.88 320 791955 23496 89812676
Blepharospasm 25.75 9.88 651 791624 54794 89781378
Breast cancer metastatic 25.65 9.88 59 792216 15073 89821099
Respiratory acidosis 25.65 9.88 20 792255 8099 89828073
Subarachnoid haemorrhage 25.62 9.88 76 792199 17828 89818344
Acidosis 25.58 9.88 45 792230 12691 89823481
Incorrect dose administered 25.56 9.88 511 791764 78419 89757753
Toxic encephalopathy 25.54 9.88 23 792252 8676 89827496
Finger deformity 25.54 9.88 417 791858 32480 89803692
Enthesopathy 25.51 9.88 155 792120 9249 89826923
Dysmorphism 25.50 9.88 64 792211 2504 89833668
Labelled drug-drug interaction medication error 25.42 9.88 56 792219 14526 89821646
Acute chest syndrome 25.35 9.88 40 792235 1108 89835064
Pulmonary congestion 25.34 9.88 86 792189 19347 89816825
Graft versus host disease in gastrointestinal tract 25.32 9.88 4 792271 4384 89831788
Immune reconstitution inflammatory syndrome 25.23 9.88 15 792260 7004 89829168
Blood glucose decreased 25.22 9.88 112 792163 23317 89812855
Product administered to patient of inappropriate age 25.20 9.88 5 792270 4648 89831524
Hypervolaemia 25.19 9.88 175 792100 32582 89803590
Anuria 24.94 9.88 58 792217 14760 89821412
Toxic epidermal necrolysis 24.90 9.88 174 792101 32354 89803818
Smear cervix abnormal 24.85 9.88 72 792203 3070 89833102
Blood potassium decreased 24.77 9.88 282 791993 47445 89788727
Maternal exposure timing unspecified 24.70 9.88 303 791972 22180 89813992
Eosinophil count increased 24.69 9.88 48 792227 13033 89823139
Colitis microscopic 24.68 9.88 37 792238 11122 89825050
Paranoia 24.68 9.88 47 792228 12861 89823311
Dysphonia 24.68 9.88 395 791880 62689 89773483
Oral candidiasis 24.59 9.88 195 792080 35260 89800912
Ileus 24.58 9.88 69 792206 16477 89819695
Polyuria 24.51 9.88 31 792244 10009 89826163
Limb deformity 24.48 9.88 86 792189 4066 89832106
Renal tubular necrosis 24.47 9.88 57 792218 14498 89821674
Device breakage 24.42 9.88 54 792221 13990 89822182
Presyncope 24.41 9.88 170 792105 31635 89804537
Sexual dysfunction 24.32 9.88 6 792269 4798 89831374
Myopathy 24.32 9.88 51 792224 13467 89822705
Latent tuberculosis 24.32 9.88 69 792206 2907 89833265
Prescribed overdose 24.32 9.88 1065 791210 96560 89739612
Seronegative arthritis 24.22 9.88 255 792020 17979 89818193
Heart rate increased 24.14 9.88 777 791498 112125 89724047
Middle insomnia 24.04 9.88 71 792204 16680 89819492
Lymphoedema 23.82 9.88 53 792222 13700 89822472
Bradykinesia 23.71 9.88 15 792260 6773 89829399
Acute myocardial infarction 23.69 9.88 193 792082 34697 89801475
Breast cancer female 23.68 9.88 60 792215 14826 89821346
Pallor 23.65 9.88 188 792087 33977 89802195
Agranulocytosis 23.59 9.88 194 792081 34808 89801364
Sinus bradycardia 23.51 9.88 73 792202 16879 89819293
Pulseless electrical activity 23.49 9.88 26 792249 8906 89827266
Cyanosis 23.44 9.88 89 792186 19366 89816806
Electrocardiogram QRS complex prolonged 23.34 9.88 18 792257 7330 89828842
Tubulointerstitial nephritis 23.33 9.88 128 792147 25215 89810957
Treatment noncompliance 23.32 9.88 315 791960 51412 89784760
Systemic inflammatory response syndrome 23.32 9.88 14 792261 6502 89829670
Ear infection 23.28 9.88 786 791489 68989 89767183
Bradypnoea 23.23 9.88 6 792269 4652 89831520
Schizoaffective disorder 23.18 9.88 8 792267 5139 89831033
Drug effective for unapproved indication 23.17 9.88 21 792254 7897 89828275
Bacteraemia 23.17 9.88 108 792167 22192 89813980
Atrial septal defect 23.15 9.88 137 792138 8097 89828075
Malignant mediastinal neoplasm 23.10 9.88 43 792232 1365 89834807
Hyperbilirubinaemia 23.09 9.88 55 792220 13881 89822291
Acute pulmonary oedema 22.95 9.88 30 792245 9550 89826622
Body tinea 22.89 9.88 55 792220 2093 89834079
Metastases to lymph nodes 22.85 9.88 42 792233 11647 89824525
Atrioventricular block 22.81 9.88 26 792249 8789 89827383
Rales 22.78 9.88 67 792208 15760 89820412
Complication associated with device 22.78 9.88 90 792185 19359 89816813
Pulmonary alveolar haemorrhage 22.74 9.88 12 792263 5986 89830186
Atrial tachycardia 22.69 9.88 12 792263 5978 89830194
Multiple allergies 22.62 9.88 63 792212 15083 89821089
Cytomegalovirus viraemia 22.34 9.88 20 792255 7566 89828606
Skin toxicity 22.31 9.88 16 792259 6763 89829409
Subdural haematoma 22.16 9.88 73 792202 16572 89819600
Drug tolerance 22.15 9.88 247 792028 17669 89818503
Hyperuricaemia 21.93 9.88 16 792259 6703 89829469
Dissociation 21.91 9.88 16 792259 6699 89829473
Head injury 21.88 9.88 171 792104 31017 89805155
Hypernatraemia 21.88 9.88 30 792245 9357 89826815
Chronic obstructive pulmonary disease 21.85 9.88 485 791790 73344 89762828
Oliguria 21.83 9.88 37 792238 10587 89825585
Antinuclear antibody positive 21.79 9.88 147 792128 9094 89827078
Generalised oedema 21.79 9.88 89 792186 18964 89817208
Right ventricular failure 21.78 9.88 90 792185 19115 89817057
Insurance issue 21.75 9.88 39 792236 10919 89825253
Rheumatoid lung 21.67 9.88 82 792193 4021 89832151
Mood altered 21.60 9.88 77 792198 17067 89819105
Urinary tract infection 21.59 9.88 2340 789935 303292 89532880
Blood lactic acid increased 21.54 9.88 27 792248 8751 89827421
Product adhesion issue 21.48 9.88 9 792266 5133 89831039
Glomerular filtration rate decreased 21.36 9.88 76 792199 16856 89819316
Respiratory tract congestion 21.29 9.88 146 792129 27264 89808908
Hypophosphataemia 21.29 9.88 63 792212 14791 89821381
Chronic graft versus host disease 21.29 9.88 5 792270 4134 89832038
Respiration abnormal 21.14 9.88 23 792252 7940 89828232
Rotator cuff repair 21.14 9.88 58 792217 2396 89833776
Transplant dysfunction 20.88 9.88 10 792265 5272 89830900
Therapy interrupted 20.87 9.88 310 791965 49798 89786374
Multiple sclerosis 20.79 9.88 150 792125 27690 89808482
Device issue 20.70 9.88 162 792113 29375 89806797
Palmoplantar keratoderma 20.69 9.88 3 792272 3504 89832668
Night sweats 20.67 9.88 1348 790927 127418 89708754
Total lung capacity increased 20.63 9.88 9 792266 5012 89831160
Bone marrow failure 20.63 9.88 181 792094 32040 89804132
Nail disorder 20.63 9.88 669 791606 58398 89777774
Hallucinations, mixed 20.59 9.88 13 792262 5876 89830296
Synovial disorder 20.52 9.88 67 792208 3051 89833121
Hepatitis acute 20.50 9.88 40 792235 10847 89825325
Product storage error 20.46 9.88 99 792176 20142 89816030
Body height below normal 20.46 9.88 53 792222 2115 89834057
Hyperprolactinaemia 20.41 9.88 11 792264 5422 89830750
Gastroenteritis viral 20.40 9.88 376 791899 29979 89806193
Sneezing 20.38 9.88 165 792110 29704 89806468
Infusion site erythema 20.31 9.88 57 792218 13613 89822559
Therapeutic response shortened 20.28 9.88 117 792158 22762 89813410
Body temperature increased 20.26 9.88 272 792003 44438 89791734
Salivary hypersecretion 20.25 9.88 30 792245 9062 89827110
Placental disorder 20.21 9.88 44 792231 1567 89834605
Systemic candida 20.20 9.88 9 792266 4950 89831222
Clostridium test positive 20.19 9.88 11 792264 5390 89830782
Acute coronary syndrome 20.13 9.88 40 792235 10773 89825399
Dementia 20.11 9.88 124 792151 23737 89812435
Tenosynovitis stenosans 20.06 9.88 78 792197 3875 89832297
Hallucination, auditory 19.96 9.88 72 792203 15903 89820269
Localised infection 19.94 9.88 408 791867 33154 89803018
Synovial fluid analysis 19.86 9.88 62 792213 2756 89833416
Immune effector cell-associated neurotoxicity syndrome 19.80 9.88 13 792262 5755 89830417
Developmental hip dysplasia 19.55 9.88 43 792232 1542 89834630
Adenovirus infection 19.45 9.88 8 792267 4614 89831558
Nail operation 19.45 9.88 48 792227 1858 89834314
Sputum discoloured 19.32 9.88 102 792173 20289 89815883
Laryngospasm 19.32 9.88 3 792272 3330 89832842
Klebsiella infection 19.25 9.88 38 792237 10259 89825913
Stillbirth 19.13 9.88 121 792154 7322 89828850
Visual acuity reduced 19.03 9.88 123 792152 23287 89812885
Red blood cell sedimentation rate 19.02 9.88 86 792189 4572 89831600
Plasma cell myeloma 19.00 9.88 247 792028 40581 89795591
Shock haemorrhagic 18.99 9.88 50 792225 12195 89823977
Renal injury 18.97 9.88 38 792237 10205 89825967
Post-traumatic stress disorder 18.94 9.88 19 792256 6809 89829363
Bone lesion 18.92 9.88 17 792258 6420 89829752
Hereditary angioedema 18.89 9.88 33 792242 9332 89826840
Blood pressure inadequately controlled 18.83 9.88 16 792259 6208 89829964
Immune-mediated enterocolitis 18.81 9.88 9 792266 4748 89831424
Tumour marker increased 18.73 9.88 14 792261 5793 89830379
Walking aid user 18.64 9.88 424 791851 35082 89801090
Generalised tonic-clonic seizure 18.60 9.88 205 792070 34698 89801474
Bundle branch block left 18.58 9.88 25 792250 7860 89828312
Blindness 18.48 9.88 146 792129 26422 89809750
Neck mass 18.41 9.88 75 792200 3807 89832365
Foetal anticonvulsant syndrome 18.40 9.88 26 792249 651 89835521
Loose body in joint 18.40 9.88 39 792236 1363 89834809
Pre-eclampsia 18.37 9.88 162 792113 10886 89825286
Diabetes insipidus 18.37 9.88 3 792272 3209 89832963
Spinal stenosis 18.36 9.88 233 792042 17191 89818981
Injection site pruritus 18.36 9.88 608 791667 53226 89782946
Sleep terror 18.35 9.88 8 792267 4456 89831716
Anti-neutrophil cytoplasmic antibody positive vasculitis 18.34 9.88 6 792269 3987 89832185
Malaise 18.31 9.88 4697 787578 581289 89254883
Pulmonary haemorrhage 18.28 9.88 26 792249 7987 89828185
Lacrimation increased 18.24 9.88 150 792125 26912 89809260
Hepatitis B reactivation 18.20 9.88 6 792269 3968 89832204
Blood test abnormal 18.12 9.88 108 792167 20844 89815328
Coronary artery disease 18.11 9.88 197 792078 33426 89802746
Affective disorder 18.07 9.88 25 792250 7768 89828404
Haematemesis 18.01 9.88 198 792077 33528 89802644
Postoperative wound infection 17.94 9.88 188 792087 13238 89822934
Impaired gastric emptying 17.88 9.88 55 792220 12754 89823418
Throat tightness 17.85 9.88 168 792107 29316 89806856
Hyperthermia 17.76 9.88 40 792235 10295 89825877
Blood phosphorus decreased 17.76 9.88 11 792264 5023 89831149
Hypoalbuminaemia 17.72 9.88 75 792200 15822 89820350
Electrolyte imbalance 17.70 9.88 128 792147 23617 89812555
Hyperlactacidaemia 17.66 9.88 7 792268 4129 89832043
Cleft lip and palate 17.61 9.88 27 792248 729 89835443
Septic shock 17.56 9.88 581 791694 83579 89752593
Asthma 17.50 9.88 1851 790424 240309 89595863
Euglycaemic diabetic ketoacidosis 17.50 9.88 17 792258 6184 89829988
Therapy non-responder 17.47 9.88 1405 790870 135299 89700873
Haemodynamic instability 17.40 9.88 49 792226 11690 89824482
Synovial cyst 17.36 9.88 168 792107 11584 89824588
Progressive multifocal leukoencephalopathy 17.36 9.88 74 792201 15581 89820591
Renal disorder 17.27 9.88 230 792045 37629 89798543
Injection site erythema 17.25 9.88 1039 791236 97463 89738709
Rhinovirus infection 17.23 9.88 16 792259 5947 89830225
Pseudomonal sepsis 17.23 9.88 8 792267 4294 89831878
Product dose omission in error 17.04 9.88 107 792168 20396 89815776
Ventricular extrasystoles 17.03 9.88 59 792216 13191 89822981
Dermatitis exfoliative 17.03 9.88 14 792261 5522 89830650
Anosmia 17.02 9.88 38 792237 9810 89826362
Ankle arthroplasty 17.01 9.88 59 792216 2772 89833400
Cholelithiasis 16.98 9.88 340 791935 52166 89784006
Abdominal distension 16.92 9.88 951 791324 129650 89706522
Enterocolitis 16.91 9.88 42 792233 10448 89825724
Blood lactate dehydrogenase increased 16.90 9.88 145 792130 25787 89810385
Amyloid arthropathy 16.82 9.88 42 792233 1638 89834534
Cardiac failure acute 16.81 9.88 51 792224 11878 89824294
Staphylococcal infection 16.78 9.88 310 791965 48129 89788043
Extra dose administered 16.74 9.88 34 792241 9084 89827088
Anhedonia 16.74 9.88 48 792227 11383 89824789
Hepatic necrosis 16.65 9.88 19 792256 6419 89829753
Hypoglycaemic coma 16.65 9.88 3 792272 2987 89833185
Potentiating drug interaction 16.59 9.88 15 792260 5647 89830525
Peripheral sensory neuropathy 16.56 9.88 35 792240 9215 89826957
Personality change 16.46 9.88 24 792251 7297 89828875
Type 1 diabetes mellitus 16.31 9.88 11 792264 4801 89831371
Tenosynovitis 16.30 9.88 197 792078 14370 89821802
Hypogammaglobulinaemia 16.24 9.88 44 792231 10630 89825542
Human antichimeric antibody positive 16.18 9.88 43 792232 1743 89834429
Dermatitis acneiform 16.17 9.88 19 792256 6335 89829837
Neutrophilia 16.12 9.88 16 792259 5762 89830410
Pneumonia viral 16.12 9.88 33 792242 8790 89827382
Catheter site pain 16.09 9.88 15 792260 5564 89830608
Amylase increased 16.08 9.88 23 792252 7049 89829123
Pneumatosis intestinalis 16.08 9.88 5 792270 3432 89832740
Unevaluable event 16.03 9.88 361 791914 54487 89781685
Skin plaque 16.03 9.88 40 792235 9935 89826237
Laryngeal oedema 16.03 9.88 22 792253 6859 89829313
Antibody test positive 16.01 9.88 60 792215 2929 89833243
Congenital arterial malformation 16.00 9.88 17 792258 314 89835858
Diplopia 15.97 9.88 167 792108 28547 89807625
Pharyngeal swelling 15.88 9.88 40 792235 9904 89826268
Cardiac disorder 15.87 9.88 377 791898 56495 89779677
Temperature intolerance 15.85 9.88 53 792222 11977 89824195
Troponin increased 15.85 9.88 61 792214 13220 89822952
Pneumonitis 15.83 9.88 281 791994 43889 89792283
Product administration interrupted 15.81 9.88 56 792219 12436 89823736
Polyhydramnios 15.71 9.88 53 792222 2455 89833717
Facial paralysis 15.69 9.88 76 792199 15458 89820714
Maternal exposure during delivery 15.64 9.88 7 792268 3839 89832333
Spondylitis 15.54 9.88 191 792084 13987 89822185
Hyperthyroidism 15.51 9.88 95 792180 18215 89817957
Ileus paralytic 15.47 9.88 13 792262 5072 89831100
Limb reduction defect 15.44 9.88 23 792252 605 89835567
Malignant melanoma 15.37 9.88 173 792102 12403 89823769
Device leakage 15.34 9.88 41 792234 9950 89826222
Bundle branch block right 15.33 9.88 15 792260 5438 89830734
Arthritis infective 15.32 9.88 121 792154 7871 89828301
Nephropathy toxic 15.32 9.88 58 792217 12630 89823542
Clear cell renal cell carcinoma 15.30 9.88 39 792236 1541 89834631
Rash macular 15.29 9.88 180 792095 30100 89806072
Feeding disorder 15.28 9.88 90 792185 17422 89818750
Liver disorder 15.28 9.88 1245 791030 120024 89716148
Thrombosis 15.21 9.88 506 791769 72745 89763427
Infusion site swelling 15.19 9.88 52 792223 11668 89824504
Candida infection 15.14 9.88 208 792067 33849 89802323
Lymphatic fistula 15.13 9.88 37 792238 1424 89834748
Nystagmus 15.00 9.88 25 792250 7202 89828970
Device physical property issue 15.00 9.88 3 792272 2773 89833399
Erythema of eyelid 14.96 9.88 5 792270 3278 89832894
Haematuria 14.95 9.88 215 792060 34722 89801450
Hypertelorism 14.95 9.88 21 792254 523 89835649
Scleritis 14.87 9.88 87 792188 5121 89831051
Femur fracture 14.84 9.88 517 791758 45565 89790607
Hyperammonaemia 14.78 9.88 21 792254 6454 89829718
Skin papilloma 14.77 9.88 92 792183 5538 89830634
Hyperpyrexia 14.70 9.88 12 792263 4749 89831423
Pruritus genital 14.69 9.88 11 792264 4547 89831625
Bezoar 14.68 9.88 3 792272 2731 89833441
Dyspepsia 14.63 9.88 1962 790313 196198 89639974
Trigeminal neuralgia 14.61 9.88 9 792266 4122 89832050
Loss of employment 14.61 9.88 4 792271 2983 89833189
Reversible cerebral vasoconstriction syndrome 14.60 9.88 9 792266 4121 89832051
Breast feeding 14.53 9.88 27 792248 856 89835316
Nasal oedema 14.50 9.88 103 792172 6481 89829691
Nasal obstruction 14.46 9.88 53 792222 2559 89833613
Product substitution issue 14.45 9.88 95 792180 17913 89818259
Infusion site pruritus 14.42 9.88 23 792252 6742 89829430
Pain of skin 14.38 9.88 82 792193 16000 89820172
Sleep disorder due to a general medical condition 14.37 9.88 290 791985 44448 89791724
Femoral hernia incarcerated 14.37 9.88 37 792238 1471 89834701
Retrognathia 14.36 9.88 21 792254 543 89835629
Feeling hot 14.34 9.88 547 791728 77461 89758711
Skin lesion 14.27 9.88 235 792040 37130 89799042
Back injury 14.26 9.88 520 791755 46102 89790070
Epstein-Barr virus associated lymphoproliferative disorder 14.16 9.88 3 792272 2664 89833508
Brain injury 14.08 9.88 29 792246 7709 89828463
Kidney transplant rejection 14.07 9.88 13 792262 4844 89831328
Hepatitis cholestatic 14.02 9.88 34 792241 8527 89827645
Exercise tolerance decreased 14.00 9.88 28 792247 7523 89828649
Long QT syndrome 13.99 9.88 9 792266 4028 89832144
Bone density increased 13.97 9.88 27 792248 882 89835290
Pneumothorax 13.96 9.88 104 792171 19063 89817109
Abortion incomplete 13.94 9.88 5 792270 3135 89833037
Metastasis 13.92 9.88 20 792255 6117 89830055
Polydipsia 13.91 9.88 10 792265 4221 89831951
Pancreatitis 13.88 9.88 485 791790 69341 89766831
Pneumonia bacterial 13.85 9.88 61 792214 12729 89823443
Wound infection pseudomonas 13.79 9.88 44 792231 1979 89834193
Atrial flutter 13.76 9.88 48 792227 10710 89825462
Intracranial pressure increased 13.74 9.88 24 792251 6787 89829385
Incoherent 13.64 9.88 14 792261 4963 89831209
Immune thrombocytopenia 13.57 9.88 65 792210 13261 89822911
Ataxia 13.57 9.88 97 792178 17945 89818227
Hepatic encephalopathy 13.55 9.88 68 792207 13704 89822468
Rectal haemorrhage 13.55 9.88 588 791687 82156 89754016
Tetany 13.53 9.88 3 792272 2581 89833591
Haemorrhage in pregnancy 13.53 9.88 46 792229 2139 89834033
Hypokinesia 13.53 9.88 81 792194 15616 89820556
Nocardiosis 13.43 9.88 3 792272 2567 89833605
Ulcer haemorrhage 13.41 9.88 313 791962 26008 89810164
Hepatitis fulminant 13.40 9.88 9 792266 3936 89832236
Hypoventilation 13.30 9.88 16 792259 5280 89830892
Speech disorder developmental 13.28 9.88 27 792248 916 89835256
Device use issue 13.26 9.88 8 792267 3705 89832467
Blood sodium decreased 13.24 9.88 166 792109 27447 89808725
Skin weeping 13.23 9.88 4 792271 2796 89833376
Crohn's disease 13.19 9.88 80 792195 4771 89831401
Fracture delayed union 13.17 9.88 50 792225 2456 89833716
Short stature 13.17 9.88 29 792246 1041 89835131
Cholecystitis chronic 13.15 9.88 43 792232 9783 89826389
Neoplasm recurrence 13.14 9.88 6 792269 3253 89832919
Eosinophilic granulomatosis with polyangiitis 13.12 9.88 3 792272 2527 89833645
Eyelid oedema 13.11 9.88 54 792221 11480 89824692
Full blood count abnormal 13.06 9.88 233 792042 36364 89799808
Pregnancy with contraceptive device 13.05 9.88 15 792260 5051 89831121
Hypercapnia 13.04 9.88 24 792251 6653 89829519
Endophthalmitis 13.04 9.88 13 792262 4672 89831500
Needle issue 13.03 9.88 70 792205 13864 89822308
Mouth ulceration 13.00 9.88 449 791826 39525 89796647
Iritis 12.84 9.88 65 792210 3621 89832551
Infection susceptibility increased 12.82 9.88 68 792207 3858 89832314
Increased appetite 12.81 9.88 56 792219 11709 89824463
Atrioventricular block second degree 12.80 9.88 12 792263 4440 89831732
Gastroschisis 12.79 9.88 17 792258 401 89835771
Bone density decreased 12.78 9.88 218 792057 17127 89819045
Cushingoid 12.71 9.88 143 792132 10252 89825920
Choking 12.66 9.88 58 792217 11975 89824197
Nail injury 12.63 9.88 24 792251 774 89835398
Skin ulcer 12.63 9.88 547 791728 49528 89786644
End stage renal disease 12.54 9.88 36 792239 8535 89827637
Cystitis haemorrhagic 12.47 9.88 18 792257 5495 89830677
Migraine 12.47 9.88 1872 790403 188520 89647652
Dermatitis 12.45 9.88 129 792146 22091 89814081
Pathological fracture 12.43 9.88 43 792232 9617 89826555
Neuralgia 12.40 9.88 197 792078 31303 89804869
Disturbance in social behaviour 12.39 9.88 11 792264 4177 89831995
Uterine perforation 12.37 9.88 30 792245 7524 89828648
Central nervous system lesion 12.34 9.88 56 792219 11590 89824582
Epidermal necrosis 12.32 9.88 47 792228 2314 89833858
Confusional state 12.23 9.88 3667 788608 382538 89453634
Carotid artery occlusion 12.21 9.88 23 792252 6319 89829853
Osteolysis 12.19 9.88 8 792267 3542 89832630
Metastases to peritoneum 12.18 9.88 11 792264 4144 89832028
Device deployment issue 12.15 9.88 15 792260 4894 89831278
Congenital anomaly 12.12 9.88 96 792179 6251 89829921
Device malfunction 12.08 9.88 121 792154 20856 89815316
Catheter site erythema 12.06 9.88 15 792260 4879 89831293
Myocardial ischaemia 12.05 9.88 71 792204 13743 89822429
International normalised ratio fluctuation 12.01 9.88 6 792269 3087 89833085
Abnormal dreams 12.00 9.88 54 792221 11203 89824969
Skin fissures 11.99 9.88 120 792155 20689 89815483
Restless legs syndrome 11.96 9.88 132 792143 22338 89813834
Neutrophil count increased 11.94 9.88 110 792165 19280 89816892
Cross sensitivity reaction 11.93 9.88 5 792270 2852 89833320
Immunosuppressant drug level increased 11.90 9.88 14 792261 4666 89831506
Implant site pain 11.87 9.88 4 792271 2608 89833564
Product residue present 11.84 9.88 12 792263 4279 89831893
Blood loss anaemia 11.83 9.88 47 792228 10093 89826079
Cerebral haematoma 11.82 9.88 12 792263 4277 89831895
Ageusia 11.82 9.88 87 792188 15989 89820183
Intestinal ischaemia 11.80 9.88 39 792236 8844 89827328
Lung transplant 11.78 9.88 9 792266 3683 89832489
Benign ovarian tumour 11.77 9.88 18 792257 485 89835687
Osteonecrosis 11.76 9.88 160 792115 26081 89810091
Varicella zoster virus infection 11.69 9.88 10 792265 3867 89832305
Lip oedema 11.66 9.88 14 792261 4625 89831547
Terminal state 11.66 9.88 5 792270 2813 89833359
Ingrown hair 11.65 9.88 20 792255 595 89835577
Clostridium difficile infection 11.63 9.88 235 792040 36010 89800162
Intervertebral disc degeneration 11.62 9.88 214 792061 17060 89819112
Thirst 11.59 9.88 89 792186 16206 89819966
Ventricular hypokinesia 11.53 9.88 18 792257 5323 89830849
Productive cough 11.53 9.88 553 791722 76510 89759662
Hypocalcaemia 11.51 9.88 282 791993 42086 89794086
Congenital cerebral cyst 11.50 9.88 13 792262 258 89835914
Eye swelling 11.49 9.88 184 792091 29202 89806970
Hypotonia 11.48 9.88 56 792219 11370 89824802
Oligoarthritis 11.46 9.88 19 792256 549 89835623
Hypertransaminasaemia 11.46 9.88 86 792189 15739 89820433
Pancreatic steatosis 11.46 9.88 36 792239 1606 89834566
Pneumonia fungal 11.45 9.88 28 792247 7003 89829169
Exomphalos 11.44 9.88 19 792256 550 89835622
Inadequate analgesia 11.44 9.88 7 792268 3217 89832955
Cholangitis 11.39 9.88 29 792246 7153 89829019
Heparin-induced thrombocytopenia 11.38 9.88 18 792257 5294 89830878
Inflammatory marker increased 11.38 9.88 127 792148 9087 89827085
Product physical issue 11.36 9.88 20 792255 5640 89830532
Persecutory delusion 11.33 9.88 7 792268 3201 89832971
Dermatitis contact 11.27 9.88 71 792204 13524 89822648
Hyperreflexia 11.25 9.88 26 792249 6631 89829541
Cleft palate 11.23 9.88 31 792244 1285 89834887
Tendonitis 11.15 9.88 255 792020 21117 89815055
Sensitisation 11.15 9.88 12 792263 4163 89832009
Mental impairment 11.12 9.88 93 792182 16627 89819545
Pulmonary function test abnormal 11.11 9.88 5 792270 2734 89833438
Subacute cutaneous lupus erythematosus 11.09 9.88 9 792266 3573 89832599
Adverse drug reaction 11.07 9.88 1174 791101 115527 89720645
Learning disorder 11.04 9.88 24 792251 854 89835318
Type I hypersensitivity 11.03 9.88 12 792263 4143 89832029
Sickle cell anaemia 11.03 9.88 20 792255 622 89835550
Retinal haemorrhage 11.01 9.88 21 792254 5743 89830429
Immune-mediated hepatitis 11 9.88 6 792269 2938 89833234
Human anti-human antibody test 10.99 9.88 16 792259 412 89835760
Decreased appetite 10.99 9.88 3027 789248 373513 89462659
Intraocular pressure increased 10.97 9.88 29 792246 7064 89829108
Drug screen positive 10.95 9.88 10 792265 3747 89832425
Product availability issue 10.91 9.88 31 792244 7373 89828799
Cervical incompetence 10.89 9.88 20 792255 628 89835544
Metastases to spine 10.87 9.88 10 792265 3733 89832439
Pulmonary tuberculosis 10.87 9.88 76 792199 4758 89831414
Lipase increased 10.85 9.88 55 792220 11056 89825116
Device occlusion 10.84 9.88 43 792232 9239 89826933
Major depression 10.78 9.88 48 792227 9987 89826185
Cyst rupture 10.77 9.88 23 792252 808 89835364
Post procedural haemorrhage 10.76 9.88 40 792235 8758 89827414
Oral pain 10.76 9.88 211 792064 32472 89803700
Immunisation 10.76 9.88 3 792272 2210 89833962
Micturition urgency 10.75 9.88 56 792219 11177 89824995
Pulmonary toxicity 10.75 9.88 58 792217 11473 89824699
Paranasal sinus discomfort 10.70 9.88 24 792251 6186 89829986
Anger 10.70 9.88 73 792202 13647 89822525
Liver function test increased 10.66 9.88 871 791404 83984 89752188
Foetal distress syndrome 10.65 9.88 36 792239 1669 89834503
Wrong product administered 10.63 9.88 33 792242 7632 89828540
Staphylococcal sepsis 10.62 9.88 44 792231 9339 89826833
Colorectal cancer 10.61 9.88 11 792264 3882 89832290
Upper-airway cough syndrome 10.61 9.88 83 792192 15052 89821120
Hyperlipidaemia 10.53 9.88 139 792136 22777 89813395
Respiratory disorder 10.53 9.88 461 791814 64355 89771817
Flatulence 10.52 9.88 278 791997 41089 89795083
Wrong technique in device usage process 10.51 9.88 22 792253 5813 89830359
Inhibitory drug interaction 10.47 9.88 55 792220 3108 89833064
Cold sweat 10.45 9.88 76 792199 14005 89822167
Catheter site haemorrhage 10.41 9.88 10 792265 3658 89832514
Cardiac failure chronic 10.41 9.88 21 792254 5625 89830547
Lymph gland infection 10.40 9.88 18 792257 539 89835633
Embolism 10.40 9.88 45 792230 9436 89826736
Pharyngeal oedema 10.38 9.88 74 792201 13697 89822475
Skin cancer 10.36 9.88 171 792104 13348 89822824
Facial pain 10.34 9.88 70 792205 13112 89823060
Cardiac tamponade 10.34 9.88 21 792254 5611 89830561
Hypertension 10.34 9.88 4290 787985 453242 89382930
Cell death 10.33 9.88 7 792268 3048 89833124
Hypochloraemia 10.31 9.88 5 792270 2617 89833555
Pruritus 10.31 9.88 4426 787849 537099 89299073
Blood parathyroid hormone decreased 10.30 9.88 157 792118 12059 89824113
Incontinence 10.22 9.88 72 792203 13363 89822809
Hydronephrosis 10.17 9.88 65 792210 12337 89823835
Cardiopulmonary failure 10.15 9.88 13 792262 4175 89831997
Hypoglycaemia neonatal 10.15 9.88 27 792248 1095 89835077
Bronchial secretion retention 10.10 9.88 10 792265 3605 89832567
Granuloma skin 10.08 9.88 140 792135 10540 89825632
Talipes 10.08 9.88 35 792240 1645 89834527
Electrocardiogram abnormal 10.05 9.88 51 792224 10247 89825925
Dialysis 10.01 9.88 58 792217 11271 89824901
Congestive cardiomyopathy 9.97 9.88 32 792243 7322 89828850
Joint warmth 9.97 9.88 36 792239 1726 89834446
Therapeutic response unexpected 9.95 9.88 133 792142 21747 89814425
Impaired work ability 9.90 9.88 230 792045 19096 89817076
Fracture 9.90 9.88 258 792017 21818 89814354
Endodontic procedure 9.89 9.88 58 792217 3417 89832755
Malnutrition 9.89 9.88 109 792166 18449 89817723
Dependence 9.89 9.88 3 792272 2092 89834080
Induced labour 9.88 9.88 25 792250 983 89835189
Ventricular arrhythmia 9.88 9.88 14 792261 4307 89831865
Lower gastrointestinal haemorrhage 9.88 9.88 42 792233 8850 89827322

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 644.94 10.14 935 218192 41505 42360703
Drug abuse 356.42 10.14 56 219071 104715 42297493
Foetal exposure during pregnancy 333.85 10.14 746 218381 46565 42355643
Toxicity to various agents 312.94 10.14 433 218694 228703 42173505
Psoriatic arthropathy 263.45 10.14 466 218661 24501 42377707
Completed suicide 252.73 10.14 90 219037 96375 42305833
Arthralgia 246.49 10.14 1852 217275 203386 42198822
Drug interaction 203.68 10.14 698 218429 266301 42135907
Sickle cell anaemia with crisis 152.11 10.14 155 218972 4735 42397473
Psoriasis 149.34 10.14 569 218558 48035 42354173
Joint swelling 144.93 10.14 713 218414 67309 42334899
Dysmorphism 139.12 10.14 124 219003 3192 42399016
Intentional overdose 131.35 10.14 50 219077 51406 42350802
Musculoskeletal stiffness 115.64 10.14 595 218532 57170 42345038
Arthritis 108.92 10.14 467 218660 41598 42360610
Pain 105.36 10.14 1806 217321 243042 42159166
Synovitis 100.38 10.14 237 218890 15330 42386878
Blood pressure fluctuation 97.94 10.14 333 218794 26575 42375633
Premature baby 95.50 10.14 299 218828 22854 42379354
Enthesopathy 93.93 10.14 120 219007 4708 42397500
Product use in unapproved indication 91.59 10.14 564 218563 183892 42218316
Blood pressure systolic increased 90.52 10.14 333 218794 27635 42374573
Small for dates baby 90.32 10.14 123 219004 5140 42397068
Acute kidney injury 88.41 10.14 1343 217784 365994 42036214
Coma 85.90 10.14 89 219038 53465 42348743
Arthropathy 83.20 10.14 337 218790 29260 42372948
Exposure during pregnancy 83.09 10.14 154 218973 8394 42393814
Hepatic function abnormal 82.37 10.14 86 219041 51481 42350727
Off label use 81.95 10.14 2581 216546 635754 41766454
Disease progression 81.17 10.14 421 218706 143235 42258973
Death 80.02 10.14 1830 217297 469355 41932853
Tenosynovitis 79.48 10.14 109 219018 4586 42397622
Serotonin syndrome 76.95 10.14 19 219108 25826 42376382
C-reactive protein abnormal 76.77 10.14 156 218971 9105 42393103
Blood pressure systolic abnormal 75.59 10.14 116 219011 5412 42396796
Rhabdomyolysis 74.61 10.14 183 218944 77836 42324372
Overdose 70.41 10.14 290 218837 104974 42297234
Speech disorder developmental 70.29 10.14 72 219055 2213 42399995
Neonatal respiratory distress syndrome 67.85 10.14 99 219028 4414 42397794
Drug resistance 67.04 10.14 47 219080 34201 42368007
Sedation 66.31 10.14 37 219090 30438 42371770
Maternal exposure during pregnancy 64.44 10.14 123 219004 6855 42395353
Blood pressure diastolic abnormal 64.13 10.14 114 219013 6014 42396194
Drug dependence 63.77 10.14 35 219092 29059 42373149
Foetal anticonvulsant syndrome 62.82 10.14 51 219076 1151 42401057
Low birth weight baby 61.42 10.14 149 218978 9806 42392402
Suicide attempt 60.89 10.14 89 219038 46011 42356197
Osteoarthritis 56.42 10.14 262 218865 24143 42378065
Hypoglycaemia neonatal 55.97 10.14 62 219065 2088 42400120
Weight decreased 55.91 10.14 1432 217695 206516 42195692
Pancytopenia 55.88 10.14 883 218244 116860 42285348
Febrile neutropenia 55.83 10.14 648 218479 185055 42217153
Alanine aminotransferase abnormal 55.68 10.14 95 219032 4849 42397359
Heart rate decreased 53.88 10.14 347 218780 36185 42366023
Hypospadias 53.27 10.14 78 219049 3489 42398719
Maternal drugs affecting foetus 53.11 10.14 81 219046 3758 42398450
Atrial septal defect 52.62 10.14 122 219005 7797 42394411
Learning disorder 51.48 10.14 44 219083 1069 42401139
Angioedema 51.35 10.14 87 219040 42390 42359818
Peripheral swelling 49.87 10.14 695 218432 89575 42312633
Palmar-plantar erythrodysaesthesia syndrome 49.28 10.14 22 219105 20560 42381648
Cryptorchism 48.59 10.14 56 219071 1971 42400237
Autism spectrum disorder 48.53 10.14 68 219059 2920 42399288
Joint effusion 48.48 10.14 99 219028 5798 42396410
Blood pressure diastolic decreased 48.45 10.14 140 218987 10235 42391973
Nasopharyngitis 48.15 10.14 651 218476 83345 42318863
Rheumatoid nodule 46.92 10.14 67 219060 2928 42399280
Haemoglobin decreased 46.73 10.14 948 218179 131523 42270685
Altered state of consciousness 46.49 10.14 49 219078 29210 42372998
Drug ineffective for unapproved indication 45.94 10.14 106 219021 46057 42356151
Poisoning 45.36 10.14 10 219117 14689 42387519
Drug ineffective 44.96 10.14 2719 216408 627478 41774730
Sleep disorder due to a general medical condition 44.46 10.14 17 219110 17436 42384772
Pain in extremity 43.99 10.14 1049 218078 149555 42252653
Jaundice neonatal 43.72 10.14 55 219072 2124 42400084
Bradycardia 43.61 10.14 259 218868 85225 42316983
Suicidal ideation 42.94 10.14 117 219010 48044 42354164
Ventricular septal defect 42.44 10.14 79 219048 4320 42397888
Intentional product misuse 42.33 10.14 169 218958 61731 42340477
Blood pressure diastolic increased 41.82 10.14 98 219029 6307 42395901
Colitis ulcerative 41.32 10.14 253 218874 25922 42376286
Lower respiratory tract infection 41.20 10.14 357 218770 40849 42361359
Syndactyly 41.16 10.14 36 219091 903 42401305
Myelosuppression 40.99 10.14 92 219035 40369 42361839
C-reactive protein increased 40.80 10.14 503 218624 63057 42339151
Drug reaction with eosinophilia and systemic symptoms 40.76 10.14 98 219029 41977 42360231
Maternal exposure during breast feeding 40.75 10.14 45 219082 1510 42400698
Multiple organ dysfunction syndrome 40.52 10.14 312 218815 96723 42305485
Grip strength decreased 40.48 10.14 69 219058 3519 42398689
Tongue disorder 40.33 10.14 87 219040 5296 42396912
Haematochezia 39.93 10.14 468 218659 57968 42344240
Body temperature decreased 39.62 10.14 163 218964 14250 42387958
Depressed level of consciousness 39.50 10.14 121 219006 47849 42354359
No adverse event 39.31 10.14 89 219038 38932 42363276
Hand deformity 39.30 10.14 70 219057 3698 42398510
Pathogen resistance 39.17 10.14 6 219121 11444 42390764
Inflammation 39.09 10.14 303 218824 33544 42368664
Infusion related reaction 38.94 10.14 481 218646 60325 42341883
Neuroleptic malignant syndrome 38.78 10.14 32 219095 21440 42380768
Knee arthroplasty 38.63 10.14 116 219011 8665 42393543
Cytomegalovirus infection 38.29 10.14 67 219060 32239 42369969
Foot deformity 38.07 10.14 82 219045 4986 42397222
Blood pressure increased 37.80 10.14 735 218392 101193 42301015
Sopor 36.87 10.14 11 219116 13191 42389017
Exposure via breast milk 36.75 10.14 54 219073 2423 42399785
Renal impairment 36.13 10.14 377 218750 109851 42292357
Joint laxity 35.65 10.14 24 219103 402 42401806
Abdominal discomfort 35.53 10.14 564 218563 74691 42327517
Respiratory arrest 35.49 10.14 57 219070 28367 42373841
Foetal growth restriction 34.67 10.14 81 219046 5202 42397006
Malignant neoplasm progression 34.61 10.14 373 218754 108027 42294181
Lactic acidosis 34.60 10.14 118 219009 45143 42357065
Red blood cell sedimentation rate increased 34.52 10.14 121 219006 9803 42392405
Cardiac failure 34.40 10.14 367 218760 106489 42295719
Drug use disorder 34.04 10.14 6 219121 10327 42391881
Cardiac murmur 33.96 10.14 143 218984 12632 42389576
Bradycardia neonatal 33.60 10.14 38 219089 1310 42400898
Polyarthritis 33.22 10.14 78 219049 5026 42397182
Developmental delay 33.05 10.14 59 219068 3123 42399085
Anal fissure 32.95 10.14 79 219048 5160 42397048
Drug intolerance 32.24 10.14 587 218540 79837 42322371
Respiratory disorder neonatal 32.24 10.14 45 219082 1925 42400283
Acute chest syndrome 31.75 10.14 33 219094 1032 42401176
Basal cell carcinoma 31.74 10.14 213 218914 22520 42379688
Psychotic disorder 31.60 10.14 64 219063 29144 42373064
Acute hepatic failure 31.39 10.14 25 219102 17048 42385160
Shock 31.34 10.14 64 219063 29057 42373151
Wound 31.28 10.14 172 218955 16945 42385263
Catarrh 31.13 10.14 84 219043 5902 42396306
Drug withdrawal syndrome neonatal 31.05 10.14 70 219057 4391 42397817
Neurotoxicity 30.89 10.14 46 219081 23605 42378603
Pulmonary alveolar haemorrhage 30.80 10.14 19 219108 14797 42387411
Delirium 30.71 10.14 152 218975 52367 42349841
Tendonitis 30.50 10.14 116 219011 9778 42392430
Anaphylactic shock 30.47 10.14 46 219081 23471 42378737
Plagiocephaly 30.32 10.14 25 219102 577 42401631
Caesarean section 29.94 10.14 45 219082 2061 42400147
Substance abuse 29.71 10.14 5 219122 8900 42393308
Renal failure 29.66 10.14 540 218587 143186 42259022
Hypoglycaemia 29.65 10.14 183 218944 59671 42342537
Hypermobility syndrome 29.30 10.14 20 219107 343 42401865
Talipes 29.29 10.14 46 219081 2190 42400018
Finger deformity 29.26 10.14 39 219088 1596 42400612
Cardiac arrest 29.23 10.14 391 218736 108929 42293279
Immune reconstitution inflammatory syndrome 29.16 10.14 8 219119 10135 42392073
Agitation 29.15 10.14 202 218925 64112 42338096
Mucocutaneous ulceration 29.06 10.14 23 219104 500 42401708
Dysgraphia 29.03 10.14 49 219078 2479 42399729
Respiratory failure 28.82 10.14 474 218653 127658 42274550
Congenital hand malformation 28.52 10.14 25 219102 629 42401579
Forced expiratory volume decreased 28.52 10.14 3 219124 7627 42394581
Electrocardiogram QT prolonged 28.47 10.14 138 218989 47807 42354401
Intentional self-injury 28.28 10.14 22 219105 15180 42387028
Aspergillus infection 28.11 10.14 24 219103 15813 42386395
Therapy partial responder 28.09 10.14 37 219090 19984 42382224
Large for dates baby 28.06 10.14 29 219098 901 42401307
Venoocclusive liver disease 28.02 10.14 9 219118 10293 42391915
Burns second degree 27.26 10.14 81 219046 6015 42396193
Haematocrit decreased 27.24 10.14 287 218840 34621 42367587
Hyperglycaemia 27.23 10.14 132 218995 45727 42356481
Ankylosing spondylitis 27.16 10.14 89 219038 6967 42395241
BK virus infection 27.05 10.14 6 219121 8778 42393430
Agitation neonatal 27.01 10.14 35 219092 1393 42400815
Fatigue 26.94 10.14 2594 216533 433047 41969161
Akathisia 26.92 10.14 10 219117 10441 42391767
Musculoskeletal pain 26.91 10.14 276 218851 33064 42369144
Post transplant lymphoproliferative disorder 26.58 10.14 7 219120 9113 42393095
Joint range of motion decreased 26.51 10.14 94 219033 7659 42394549
Respiratory depression 26.33 10.14 35 219092 18833 42383375
Mucormycosis 26.21 10.14 3 219124 7140 42395068
Systemic lupus erythematosus 26.06 10.14 106 219021 9218 42392990
Frequent bowel movements 26.04 10.14 194 218933 21213 42380995
Diaphragmatic disorder 26.02 10.14 32 219095 1207 42401001
Language disorder 25.84 10.14 46 219081 2429 42399779
Wrong technique in product usage process 25.73 10.14 122 219005 42513 42359695
Ultrasound antenatal screen 25.48 10.14 22 219105 542 42401666
Hepatic failure 25.43 10.14 105 219022 37995 42364213
Cytokine release syndrome 25.39 10.14 130 218997 44397 42357811
Tuberculosis 25.27 10.14 111 219016 9988 42392220
Therapeutic product effect decreased 25.19 10.14 310 218817 38840 42363368
Cytomegalovirus infection reactivation 25.15 10.14 13 219114 11165 42391043
Hydrops foetalis 25.13 10.14 27 219100 878 42401330
Arthritis infective 24.84 10.14 61 219066 4045 42398163
Maternal exposure before pregnancy 24.56 10.14 29 219098 1048 42401160
Foetal disorder 24.51 10.14 29 219098 1050 42401158
Hypokalaemia 24.44 10.14 243 218884 71478 42330730
Trisomy 18 24.36 10.14 26 219101 839 42401369
Astigmatism 24.21 10.14 32 219095 1299 42400909
Localised infection 23.87 10.14 183 218944 20190 42382018
Tachycardia 23.71 10.14 371 218756 100716 42301492
Skin cancer 23.57 10.14 119 219008 11343 42390865
Withdrawal syndrome 23.18 10.14 25 219102 14750 42387458
Nasal disorder 23.15 10.14 39 219088 1970 42400238
Parosmia 22.75 10.14 89 219038 7602 42394606
Vitamin D deficiency 22.74 10.14 92 219035 7981 42394227
Selective eating disorder 22.70 10.14 36 219091 1728 42400480
Drug withdrawal syndrome 22.65 10.14 48 219079 21501 42380707
Hyperbilirubinaemia neonatal 22.64 10.14 25 219102 839 42401369
Gingival pain 22.51 10.14 95 219032 8399 42393809
Dyspraxia 22.49 10.14 19 219108 454 42401754
Radiation inflammation 21.90 10.14 27 219100 1021 42401187
Anal fistula 21.82 10.14 76 219051 6137 42396071
Suspected suicide 21.78 10.14 3 219124 6196 42396012
Hypotonia neonatal 21.51 10.14 32 219095 1452 42400756
Lung neoplasm malignant 21.33 10.14 170 218957 18977 42383231
Joint stiffness 21.31 10.14 122 219005 12200 42390008
Temperature regulation disorder 21.29 10.14 28 219099 1131 42401077
Umbilical hernia 21.23 10.14 69 219058 5378 42396830
Knee deformity 21.21 10.14 23 219104 756 42401452
Motor developmental delay 21.14 10.14 22 219105 689 42401519
Proteinuria 21.11 10.14 55 219072 22928 42379280
Cleft lip and palate 21.09 10.14 25 219102 907 42401301
Metabolic acidosis 21.05 10.14 168 218959 51690 42350518
Arthrodesis 21.02 10.14 20 219107 561 42401647
Crohn's disease 20.96 10.14 47 219080 2937 42399271
Acute graft versus host disease 20.93 10.14 8 219119 8207 42394001
Rebound effect 20.88 10.14 6 219121 7373 42394835
Aggression 20.86 10.14 137 218990 44026 42358182
Pruritus 20.36 10.14 779 218348 187992 42214216
Ear disorder 20.29 10.14 37 219090 1991 42400217
Adenovirus infection 20.28 10.14 5 219122 6804 42395404
Toxic epidermal necrolysis 20.27 10.14 70 219057 26680 42375528
Serum ferritin increased 20.12 10.14 82 219045 7137 42395071
Thymus disorder 20.08 10.14 14 219113 249 42401959
Steroid dependence 20.06 10.14 78 219049 6644 42395564
Dyslexia 20.05 10.14 16 219111 352 42401856
Transient aphasia 19.68 10.14 20 219107 609 42401599
Ankyloglossia congenital 19.67 10.14 16 219111 362 42401846
Post procedural infection 19.66 10.14 70 219057 5715 42396493
Oxygen saturation decreased 19.60 10.14 453 218674 64234 42337974
Congenital foot malformation 19.58 10.14 17 219110 422 42401786
Central nervous system mass 19.55 10.14 23 219104 828 42401380
Wall motion score index abnormal 19.46 10.14 23 219104 832 42401376
Blood test abnormal 19.28 10.14 123 219004 12783 42389425
Hypopnoea 19.24 10.14 86 219041 7796 42394412
Congenital anomaly 19.22 10.14 31 219096 1510 42400698
Syringe issue 19.18 10.14 10 219117 8546 42393662
Upper respiratory tract infection 19.12 10.14 314 218813 41859 42360349
Intellectual disability 19.08 10.14 35 219092 1892 42400316
Polyomavirus-associated nephropathy 19.08 10.14 3 219124 5612 42396596
Loss of personal independence in daily activities 19.05 10.14 361 218766 49455 42352753
Cystitis haemorrhagic 18.90 10.14 7 219120 7322 42394886
Cardiac septal defect 18.89 10.14 24 219103 936 42401272
Hypoxia 18.86 10.14 249 218878 69537 42332671
Pulmonary fibrosis 18.81 10.14 215 218912 26466 42375742
Influenza 18.71 10.14 435 218692 61740 42340468
Spinal disorder 18.66 10.14 59 219068 4532 42397676
Accidental exposure to product 18.58 10.14 49 219078 20344 42381864
Blood creatine phosphokinase increased 18.53 10.14 159 218968 48179 42354029
Airway remodelling 18.51 10.14 23 219104 877 42401331
Headache 18.43 10.14 1449 217678 237920 42164288
Cellulitis 18.26 10.14 430 218697 61155 42341053
Drug dose omission by device 18.17 10.14 4 219123 5882 42396326
Red blood cell sedimentation rate 18.17 10.14 25 219102 1055 42401153
Medical device implantation 18.08 10.14 19 219108 602 42401606
Spina bifida 18.07 10.14 16 219111 408 42401800
Transfusion-related circulatory overload 18.02 10.14 21 219106 748 42401460
Synovial cyst 18.02 10.14 41 219086 2588 42399620
Pulmonary vasculitis 17.90 10.14 5 219122 6261 42395947
Multiple congenital abnormalities 17.87 10.14 18 219109 542 42401666
Ventricular tachycardia 17.79 10.14 87 219040 30073 42372135
Cardiotoxicity 17.76 10.14 8 219119 7437 42394771
Blood parathyroid hormone decreased 17.75 10.14 31 219096 1612 42400596
Renal aplasia 17.72 10.14 21 219106 762 42401446
Intervertebral disc degeneration 17.70 10.14 80 219047 7287 42394921
Fistula discharge 17.67 10.14 25 219102 1083 42401125
Acute graft versus host disease in skin 17.67 10.14 8 219119 7416 42394792
Squamous cell carcinoma of lung 17.52 10.14 37 219090 2219 42399989
Hepatic steatosis 17.52 10.14 178 218949 21270 42380938
Sinusitis 17.50 10.14 341 218786 46951 42355257
Arthritis bacterial 17.44 10.14 68 219059 5800 42396408
Cerebral haemorrhage 17.35 10.14 123 219004 38843 42363365
Cleft lip 17.32 10.14 14 219113 314 42401894
Joint ankylosis 17.29 10.14 31 219096 1646 42400562
Ear infection 17.29 10.14 119 219008 12685 42389523
Oropharyngeal pain 17.28 10.14 311 218816 42199 42360009
Haemolysis 17.28 10.14 96 219031 9493 42392715
Rhinitis 17.19 10.14 113 219014 11864 42390344
Osteonecrosis of jaw 17.18 10.14 46 219081 19003 42383205
Limb reduction defect 17.17 10.14 14 219113 318 42401890
Lacrimal disorder 17.10 10.14 14 219113 320 42401888
Atopy 17.05 10.14 23 219104 952 42401256
Congenital bladder anomaly 16.97 10.14 13 219114 269 42401939
Cytomegalovirus viraemia 16.91 10.14 17 219110 10360 42391848
Red blood cell count decreased 16.90 10.14 249 218878 32466 42369742
Malignant melanoma 16.87 10.14 94 219033 9306 42392902
Weight decrease neonatal 16.84 10.14 14 219113 327 42401881
Anti-cyclic citrullinated peptide antibody positive 16.80 10.14 33 219094 1879 42400329
Neurological symptom 16.71 10.14 16 219111 9975 42392233
Posterior reversible encephalopathy syndrome 16.68 10.14 25 219102 12796 42389412
Fall 16.66 10.14 1411 217716 233109 42169099
Loss of consciousness 16.61 10.14 355 218772 91999 42310209
Haemangioma congenital 16.61 10.14 17 219110 522 42401686
Sexual dysfunction 16.60 10.14 7 219120 6768 42395440
Device leakage 16.59 10.14 17 219110 10268 42391940
Granuloma skin 16.55 10.14 25 219102 1150 42401058
Alcohol poisoning 16.54 10.14 80 219047 7494 42394714
Otitis media 16.53 10.14 49 219078 3634 42398574
Pneumonia aspiration 16.51 10.14 171 218956 49907 42352301
Mite allergy 16.47 10.14 3 219124 5043 42397165
Pectus excavatum 16.44 10.14 12 219115 230 42401978
Hypertelorism 16.37 10.14 18 219109 601 42401607
Weight increased 16.34 10.14 695 218432 107288 42294920
Patent ductus arteriosus 16.32 10.14 47 219080 3429 42398779
Hydrocele 16.30 10.14 39 219088 2544 42399664
Exposure to toxic agent 16.28 10.14 3 219124 5001 42397207
Vitamin B12 deficiency 16.25 10.14 59 219068 4863 42397345
Infection 16.22 10.14 718 218409 111350 42290858
Back disorder 16.15 10.14 79 219048 7435 42394773
Disseminated intravascular coagulation 16.13 10.14 69 219058 24725 42377483
Heart rate irregular 16.01 10.14 139 218988 15911 42386297
Agranulocytosis 16.00 10.14 92 219035 30520 42371688
Acute respiratory distress syndrome 16.00 10.14 90 219037 30018 42372190
Electrocardiogram QRS complex prolonged 15.99 10.14 5 219122 5818 42396390
Neoplasm progression 15.78 10.14 86 219041 28914 42373294
Pleuritic pain 15.64 10.14 75 219052 7002 42395206
Hypocalcaemia 15.60 10.14 91 219036 30082 42372126
Asphyxia 15.55 10.14 12 219115 8314 42393894
Dermatitis atopic 15.37 10.14 25 219102 12379 42389829
Red blood cell sedimentation rate abnormal 15.32 10.14 49 219078 3787 42398421
Somnolence 15.27 10.14 582 218545 140523 42261685
Drug level increased 15.21 10.14 76 219051 26124 42376084
Spondyloarthropathy 15.14 10.14 21 219106 893 42401315
Neck mass 15.14 10.14 31 219096 1819 42400389
Chronic graft versus host disease 15.13 10.14 6 219121 6019 42396189
Bone cyst 15.12 10.14 29 219098 1622 42400586
Septic arthritis staphylococcal 15.07 10.14 16 219111 513 42401695
Neutropenia neonatal 15.03 10.14 21 219106 899 42401309
Urticaria 14.99 10.14 279 218848 73757 42328451
Pneumonia 14.99 10.14 2429 216698 419720 41982488
Hypertriglyceridaemia 14.95 10.14 18 219109 10108 42392100
Obsessive-compulsive disorder 14.94 10.14 8 219119 6735 42395473
Nephropathy toxic 14.93 10.14 41 219086 16797 42385411
Immunosuppression 14.82 10.14 84 219043 8369 42393839
Pulmonary pain 14.80 10.14 28 219099 1550 42400658
Bronchiolitis 14.79 10.14 49 219078 3857 42398351
Abortion spontaneous 14.79 10.14 14 219113 390 42401818
Microangiopathy 14.74 10.14 29 219098 1653 42400555
Juvenile idiopathic arthritis 14.71 10.14 38 219089 2601 42399607
Skin injury 14.69 10.14 38 219089 2603 42399605
Carcinoid tumour of the small bowel 14.64 10.14 14 219113 395 42401813
Injection site haemorrhage 14.64 10.14 107 219020 11629 42390579
Attention deficit hyperactivity disorder 14.57 10.14 42 219085 3066 42399142
Gastrointestinal infection 14.57 10.14 71 219056 6672 42395536
Exposure via skin contact 14.43 10.14 4 219123 5034 42397174
Colorectal cancer 14.43 10.14 4 219123 5034 42397174
Oesophageal fibrosis 14.43 10.14 10 219117 176 42402032
Bursitis 14.40 10.14 67 219060 6177 42396031
Disability assessment scale score increased 14.39 10.14 14 219113 404 42401804
C-reactive protein decreased 14.37 10.14 34 219093 2202 42400006
Polydactyly 14.28 10.14 24 219103 1210 42400998
Hernia pain 14.27 10.14 12 219115 285 42401923
Glycosylated haemoglobin increased 14.25 10.14 28 219099 12896 42389312
Tooth malformation 14.19 10.14 10 219117 181 42402027
Neck pain 14.18 10.14 225 218902 29789 42372419
Rash maculo-papular 14.09 10.14 124 219003 37379 42364829
Hypertransaminasaemia 14.05 10.14 16 219111 9211 42392997
Contusion 13.97 10.14 298 218829 41687 42360521
Hepatic encephalopathy 13.87 10.14 41 219086 16401 42385807
Potentiating drug interaction 13.86 10.14 8 219119 6460 42395748
Low set ears 13.81 10.14 15 219112 494 42401714
Cholelithiasis 13.80 10.14 182 218945 23164 42379044
Haematotoxicity 13.74 10.14 22 219105 10963 42391245
Endophthalmitis 13.71 10.14 3 219124 4430 42397778
Foetal distress syndrome 13.63 10.14 23 219104 1163 42401045
Euglycaemic diabetic ketoacidosis 13.63 10.14 6 219121 5654 42396554
Mydriasis 13.58 10.14 15 219112 8755 42393453
Mobility decreased 13.55 10.14 256 218871 35050 42367158
Dysstasia 13.54 10.14 121 219006 13965 42388243
Skin abrasion 13.53 10.14 80 219047 8095 42394113
Scoliosis 13.47 10.14 41 219086 3085 42399123
Blister infected 13.45 10.14 15 219112 509 42401699
Dry throat 13.40 10.14 39 219088 2863 42399345
Autoscopy 13.37 10.14 11 219116 253 42401955
Myoclonus 13.37 10.14 44 219083 17021 42385187
Arnold-Chiari malformation 13.36 10.14 13 219114 375 42401833
Microcephaly 13.34 10.14 20 219107 914 42401294
Lower respiratory tract congestion 13.32 10.14 27 219100 1573 42400635
Respiratory rate increased 13.31 10.14 100 219027 10962 42391246
Melaena 13.31 10.14 131 218996 38615 42363593
Maternal exposure timing unspecified 13.31 10.14 13 219114 377 42401831
Hepatitis E antibody positive 13.27 10.14 11 219116 256 42401952
Diverticulum 13.26 10.14 75 219052 7466 42394742
Immunodeficiency 13.15 10.14 73 219054 7217 42394991
Respiratory tract infection viral 13.14 10.14 43 219084 3363 42398845
Gangrene neonatal 13.13 10.14 10 219117 205 42402003
Thrombotic microangiopathy 13.10 10.14 36 219091 14746 42387462
Cystitis bacterial 13.09 10.14 10 219117 206 42402002
Psychiatric decompensation 12.77 10.14 3 219124 4219 42397989
Impaired work ability 12.74 10.14 106 219021 11985 42390223
Lung cancer metastatic 12.71 10.14 39 219088 2947 42399261
Hyperammonaemia 12.69 10.14 13 219114 7853 42394355
Diverticular perforation 12.66 10.14 45 219082 3671 42398537
Unresponsive to stimuli 12.62 10.14 102 219025 31301 42370907
Muscle twitching 12.58 10.14 26 219101 11754 42390454
Disease recurrence 12.58 10.14 95 219032 29583 42372625
Latent tuberculosis 12.58 10.14 27 219100 1638 42400570
Anaemia vitamin B12 deficiency 12.57 10.14 15 219112 548 42401660
Haemangioma 12.56 10.14 30 219097 1955 42400253
Hypothyroidism 12.53 10.14 105 219022 31979 42370229
Infective pulmonary exacerbation of cystic fibrosis 12.52 10.14 13 219114 7805 42394403
Hallucination 12.50 10.14 214 218913 57293 42344915
Hepatic enzyme increased 12.47 10.14 316 218811 45468 42356740
Eosinophilic myocarditis 12.43 10.14 24 219103 1349 42400859
Pleural fibrosis 12.42 10.14 24 219103 1350 42400858
Anal atresia 12.41 10.14 11 219116 281 42401927
Mania 12.38 10.14 22 219105 10525 42391683
Developmental coordination disorder 12.38 10.14 10 219117 224 42401984
Haemodynamic instability 12.35 10.14 29 219098 12528 42389680
Hepatitis fulminant 12.35 10.14 5 219122 4954 42397254
Ligament rupture 12.34 10.14 24 219103 1356 42400852
Nephrotic syndrome 12.34 10.14 16 219111 8702 42393506
Hyperkalaemia 12.31 10.14 317 218810 80141 42322067
Bone erosion 12.26 10.14 50 219077 4353 42397855
Strabismus 12.26 10.14 33 219094 2315 42399893
Educational problem 12.26 10.14 15 219112 563 42401645
Foetal heart rate deceleration abnormality 12.24 10.14 15 219112 564 42401644
Asymptomatic bacteriuria 12.23 10.14 10 219117 228 42401980
Nerve compression 12.23 10.14 47 219080 3981 42398227
Pharyngitis 12.23 10.14 83 219044 8807 42393401
Dystonia 12.22 10.14 30 219097 12760 42389448
Fistula 12.19 10.14 76 219051 7836 42394372
Cardio-respiratory arrest 12.17 10.14 220 218907 58416 42343792
Vascular insufficiency 12.14 10.14 12 219115 353 42401855
Drug-induced liver injury 12.08 10.14 132 218995 38141 42364067
Blood insulin increased 12.03 10.14 12 219115 357 42401851
Abnormal behaviour 12.02 10.14 83 219044 26368 42375840
Gross motor delay 11.98 10.14 12 219115 359 42401849
Asthma 11.95 10.14 237 218890 62077 42340131
Stevens-Johnson syndrome 11.94 10.14 66 219061 22112 42380096
Tinea pedis 11.94 10.14 30 219097 2018 42400190
Multiple-drug resistance 11.93 10.14 12 219115 7310 42394898
Hepatitis E virus test positive 11.91 10.14 11 219116 297 42401911
Hallucination, auditory 11.87 10.14 38 219089 14826 42387382
Hypermetropia 11.85 10.14 14 219113 506 42401702
Restlessness 11.75 10.14 95 219032 29154 42373054
Abdominal adhesions 11.75 10.14 27 219100 1715 42400493
Back pain 11.68 10.14 863 218264 140913 42261295
Haemoptysis 11.66 10.14 167 218960 46000 42356208
Glomerular filtration rate decreased 11.58 10.14 44 219083 16307 42385901
Nail bed bleeding 11.57 10.14 13 219114 445 42401763
Palindromic rheumatism 11.55 10.14 9 219118 191 42402017
Inguinal hernia 11.55 10.14 82 219045 8830 42393378
Blood folate increased 11.55 10.14 11 219116 309 42401899
Gamma-glutamyltransferase increased 11.53 10.14 109 219018 32388 42369820
General physical health deterioration 11.53 10.14 915 218212 150331 42251877
Brain oedema 11.52 10.14 44 219083 16283 42385925
Psychomotor retardation 11.50 10.14 49 219078 4350 42397858
Bronchopulmonary aspergillosis 11.49 10.14 56 219071 19373 42382835
Mucosal ulceration 11.45 10.14 23 219104 1331 42400877
Vein disorder 11.44 10.14 30 219097 2072 42400136
Poor venous access 11.38 10.14 70 219057 7182 42395026
Anti-erythropoietin antibody positive 11.35 10.14 18 219109 864 42401344
Disinhibition 11.33 10.14 3 219124 3892 42398316
Congenital hydronephrosis 11.29 10.14 17 219110 780 42401428
Mean cell volume increased 11.28 10.14 45 219082 3878 42398330
Hepatitis 11.28 10.14 88 219039 27212 42374996
Peripheral artery thrombosis 11.27 10.14 35 219092 2662 42399546
Blood albumin decreased 11.26 10.14 125 219002 15277 42386931
Rotator cuff syndrome 11.25 10.14 65 219062 6521 42395687
Nephrolithiasis 11.18 10.14 258 218869 36572 42365636
Tinnitus 11.16 10.14 210 218917 28728 42373480
Tender joint count decreased 11.14 10.14 10 219117 260 42401948
Swollen joint count decreased 11.14 10.14 10 219117 260 42401948
Fever neonatal 11.11 10.14 8 219119 150 42402058
Facial pain 11.10 10.14 4 219123 4256 42397952
Vomiting 11.10 10.14 1312 217815 288411 42113797
Protein deficiency 11.07 10.14 10 219117 262 42401946
Stress ulcer 11.01 10.14 10 219117 264 42401944
Myopia 11.00 10.14 22 219105 1269 42400939
Peritoneal dialysis complication 11.00 10.14 28 219099 1899 42400309
Tumour lysis syndrome 10.99 10.14 68 219059 22163 42380045
Encephalopathy 10.98 10.14 148 218979 41185 42361023
Dehiscence 10.94 10.14 15 219112 631 42401577
Pyrexia 10.93 10.14 1820 217307 392222 42009986
Complications of transplanted kidney 10.93 10.14 7 219120 5343 42396865
Cytomegalovirus chorioretinitis 10.93 10.14 5 219122 4606 42397602
Ulcer 10.93 10.14 131 218996 16310 42385898
Coccydynia 10.92 10.14 15 219112 632 42401576
Skin graft failure 10.89 10.14 8 219119 155 42402053
Anal spasm 10.89 10.14 8 219119 155 42402053
Excessive cerumen production 10.87 10.14 11 219116 333 42401875
Cardiogenic shock 10.82 10.14 124 219003 35516 42366692
Congenital genital malformation 10.80 10.14 8 219119 157 42402051
Diabetic ketoacidosis 10.76 10.14 69 219058 22298 42379910
Palmoplantar pustulosis 10.75 10.14 13 219114 482 42401726
Panniculitis 10.74 10.14 30 219097 2151 42400057
Osteochondrosis 10.72 10.14 23 219104 1395 42400813
Psychomotor skills impaired 10.68 10.14 54 219073 5150 42397058
Visuospatial deficit 10.67 10.14 7 219120 112 42402096
Ear malformation 10.66 10.14 11 219116 341 42401867
Hand fracture 10.60 10.14 36 219091 2870 42399338
Vitamin B complex deficiency 10.60 10.14 13 219114 489 42401719
Eosinophilia 10.57 10.14 113 219014 32786 42369422
Concomitant disease aggravated 10.49 10.14 11 219116 6575 42395633
Arrhythmia 10.48 10.14 145 218982 40172 42362036
Necrotising fasciitis streptococcal 10.46 10.14 8 219119 165 42402043
Normochromic normocytic anaemia 10.46 10.14 19 219108 9012 42393196
Cerebral infarction 10.45 10.14 106 219021 31063 42371145
Paranoia 10.42 10.14 37 219090 13989 42388219
Kidney infection 10.41 10.14 65 219062 6705 42395503
Non-Hodgkin's lymphoma 10.40 10.14 23 219104 1424 42400784
Kyphosis 10.39 10.14 22 219105 1322 42400886
Graft versus host disease 10.36 10.14 33 219094 12892 42389316
Nail pitting 10.33 10.14 12 219115 426 42401782
Blood homocysteine increased 10.32 10.14 10 219117 287 42401921
Nocardiosis 10.32 10.14 7 219120 5183 42397025
Abdominal pain 10.25 10.14 1124 218003 189347 42212861
Fine motor skill dysfunction 10.25 10.14 30 219097 2209 42399999
Haemoglobinuria 10.24 10.14 15 219112 671 42401537
Mutism 10.24 10.14 23 219104 1439 42400769
Fibula fracture 10.21 10.14 20 219107 1136 42401072
Meningeal disorder 10.21 10.14 11 219116 359 42401849
Bone hypertrophy 10.18 10.14 10 219117 292 42401916
Mesothelioma 10.18 10.14 12 219115 433 42401775
PCO2 decreased 10.17 10.14 26 219101 1768 42400440
Hip arthroplasty 10.16 10.14 54 219073 5251 42396957

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1206.75 9.93 1016 796523 479539 109312221
Completed suicide 1204.61 9.93 161 797378 242220 109549540
Systemic lupus erythematosus 1175.24 9.93 4269 793270 250069 109541691
Arthropathy 1105.49 9.93 4553 792986 282969 109508791
Synovitis 1091.58 9.93 4388 793151 269704 109522056
Pemphigus 1077.54 9.93 3702 793837 210868 109580892
Hand deformity 1048.85 9.93 3714 793825 214792 109576968
Joint swelling 994.24 9.93 6019 791520 436826 109354934
Glossodynia 972.33 9.93 3663 793876 218341 109573419
Wound 845.17 9.93 3641 793898 230796 109560964
Anti-cyclic citrullinated peptide antibody positive 843.07 9.93 3058 794481 178926 109612834
Rheumatoid arthritis 827.58 9.93 4307 793232 295306 109496454
Pericarditis 817.65 9.93 3439 794100 215675 109576085
Drug abuse 817.34 9.93 146 797393 177265 109614495
Drug interaction 761.67 9.93 1537 796002 498646 109293114
Maternal exposure during pregnancy 745.68 9.93 3724 793815 251159 109540601
Duodenal ulcer perforation 721.43 9.93 2863 794676 174837 109616923
Abdominal discomfort 717.49 9.93 5081 792458 388777 109402983
Arthralgia 692.02 9.93 8621 788918 771011 109020749
Swelling 691.66 9.93 4617 792922 346424 109445336
Infusion related reaction 690.05 9.93 4910 792629 376252 109415508
Helicobacter infection 679.51 9.93 2856 794683 179021 109612739
Alopecia 636.73 9.93 4658 792881 360095 109431665
Psoriatic arthropathy 616.30 9.93 2932 794607 193829 109597931
Therapeutic product effect decreased 599.97 9.93 3402 794137 240914 109550846
Intentional overdose 576.75 9.93 125 797414 132376 109659384
Discomfort 546.55 9.93 3019 794520 211688 109580072
Death 543.43 9.93 2894 794645 695975 109095785
Rheumatoid factor positive 527.78 9.93 2113 795426 129527 109662233
Contraindicated product administered 524.51 9.93 3324 794215 244943 109546817
Pain 516.30 9.93 9706 787833 945249 108846511
Musculoskeletal stiffness 506.84 9.93 3606 793933 276216 109515544
Impaired healing 497.28 9.93 2761 794778 193956 109597804
Febrile neutropenia 491.54 9.93 962 796577 315805 109475955
Acute kidney injury 486.26 9.93 2645 794894 632785 109158975
Hepatic enzyme increased 467.09 9.93 3930 793609 316962 109474798
Folliculitis 455.45 9.93 2400 795139 165253 109626507
Nasopharyngitis 425.94 9.93 4533 793006 389828 109401932
Muscle injury 400.64 9.93 2042 795497 138765 109652995
Irritable bowel syndrome 399.19 9.93 2281 795258 161934 109629826
C-reactive protein abnormal 396.05 9.93 1919 795620 127776 109663984
Blister 393.64 9.93 2899 794640 224477 109567283
Drug intolerance 388.18 9.93 4561 792978 401951 109389809
Fibromyalgia 371.82 9.93 2306 795233 168603 109623157
Lower respiratory tract infection 368.92 9.93 3006 794533 240100 109551660
Rheumatic fever 366.61 9.93 1803 795736 120776 109670984
Sleep disorder due to general medical condition, insomnia type 349.49 9.93 1600 795939 104043 109687717
Disease progression 348.26 9.93 777 796762 243257 109548503
Exposure during pregnancy 345.61 9.93 2229 795310 165195 109626565
Depressed level of consciousness 335.91 9.93 196 797343 112082 109679678
Suicide attempt 331.99 9.93 165 797374 103229 109688531
Cardiac arrest 319.59 9.93 581 796958 196172 109595588
Sinusitis 312.99 9.93 3395 794144 293293 109498467
Peripheral swelling 309.04 9.93 4352 793187 399682 109392078
Osteoarthritis 305.57 9.93 2310 795229 180313 109611447
Ill-defined disorder 303.58 9.93 2055 795484 154798 109636962
Malignant neoplasm progression 299.44 9.93 498 797041 174069 109617691
Hypersensitivity 292.44 9.93 4310 793229 399688 109392072
Weight increased 290.99 9.93 4444 793095 415200 109376560
Type 2 diabetes mellitus 288.24 9.93 2227 795312 175005 109616755
Stomatitis 280.68 9.93 3083 794456 267159 109524601
Swollen joint count increased 275.90 9.93 1266 796273 82395 109709365
Overdose 267.57 9.93 831 796708 232963 109558797
Rhabdomyolysis 267.13 9.93 284 797255 120117 109671643
Neutropenia 265.29 9.93 1598 795941 373022 109418738
Sedation 261.32 9.93 88 797451 69595 109722165
Inflammation 256.09 9.93 2319 795220 190919 109600841
Lactic acidosis 251.77 9.93 181 797358 92630 109699130
Contusion 251.44 9.93 2682 794857 230679 109561081
Treatment failure 250.98 9.93 3080 794459 274154 109517606
Bradycardia 250.07 9.93 462 797077 155055 109636705
Cardiac failure 238.03 9.93 635 796904 186991 109604769
Hepatic function abnormal 235.94 9.93 179 797360 89116 109702644
Constipation 234.40 9.93 1563 795976 356223 109435537
Coma 228.53 9.93 309 797230 117560 109674200
Facet joint syndrome 226.75 9.93 1332 796207 95496 109696264
Blood cholesterol increased 225.04 9.93 2178 795361 182607 109609153
Respiratory failure 221.99 9.93 801 796738 214531 109577229
Joint range of motion decreased 220.27 9.93 1570 795969 120262 109671498
Renal failure 218.54 9.93 866 796673 225708 109566052
Red blood cell sedimentation rate abnormal 215.79 9.93 518 797021 23991 109767769
Drug reaction with eosinophilia and systemic symptoms 215.08 9.93 166 797373 81929 109709831
Sickle cell anaemia with crisis 214.92 9.93 303 797236 9242 109782518
Serotonin syndrome 212.77 9.93 80 797459 59073 109732687
Myelosuppression 212.11 9.93 220 797319 94120 109697640
Hypotension 209.89 9.93 2593 794946 521256 109270504
Electrocardiogram QT prolonged 208.87 9.93 288 797251 108672 109683088
Renal impairment 207.76 9.93 681 796858 187764 109603996
Grip strength decreased 206.90 9.93 1132 796407 79042 109712718
Multiple organ dysfunction syndrome 205.93 9.93 496 797043 151214 109640546
Knee arthroplasty 204.71 9.93 970 796569 63978 109727782
Drug resistance 199.84 9.93 78 797461 56296 109735464
Hyponatraemia 199.84 9.93 848 796691 216805 109574955
Arthritis 191.77 9.93 1950 795589 165636 109626124
Pregnancy 191.35 9.93 803 796736 50264 109741496
Lip dry 185.15 9.93 1297 796242 98786 109692974
Hip arthroplasty 184.30 9.93 845 796694 54968 109736792
Respiratory arrest 184.20 9.93 95 797444 58204 109733556
Angioedema 182.21 9.93 267 797272 98233 109693527
Product use issue 181.07 9.93 3207 794332 308488 109483272
Drug ineffective for unapproved indication 180.40 9.93 289 797250 102549 109689211
Somnolence 179.78 9.93 1330 796209 296119 109495641
Intentional product use issue 179.26 9.93 2645 794894 245261 109546499
Blood pressure systolic abnormal 179.12 9.93 487 797052 24363 109767397
Mobility decreased 178.33 9.93 2550 794989 234872 109556888
Infection 176.65 9.93 3628 793911 358572 109433188
Hypoglycaemia 176.13 9.93 357 797182 115747 109676013
Blood pressure fluctuation 175.62 9.93 1030 796509 73794 109717966
Agitation 174.59 9.93 344 797195 112707 109679053
Blood pressure diastolic abnormal 170.42 9.93 490 797049 25325 109766435
Blood pressure systolic increased 169.37 9.93 1102 796437 81889 109709871
Injury 168.47 9.93 1988 795551 175277 109616483
Hyperhidrosis 168.10 9.93 736 796803 186562 109605198
Musculoskeletal pain 167.99 9.93 2039 795500 180984 109610776
Neoplasm progression 167.45 9.93 132 797407 64463 109727297
Sopor 166.24 9.93 31 797508 36515 109755245
Altered state of consciousness 166.19 9.93 105 797434 57521 109734239
Bursitis 160.44 9.93 1536 796003 128382 109663378
C-reactive protein increased 159.86 9.93 2331 795208 215588 109576172
Live birth 159.54 9.93 951 796588 68533 109723227
Cytokine release syndrome 155.75 9.93 166 797373 70140 109721620
Off label use 151.96 9.93 9068 788471 1491117 108300643
Hepatic failure 150.39 9.93 164 797375 68575 109723185
Cardio-respiratory arrest 149.95 9.93 388 797151 115448 109676312
Red blood cell sedimentation rate increased 146.74 9.93 1018 796521 77284 109714476
Obesity 143.88 9.93 1348 796191 112003 109679757
Gastrointestinal disorder 143.17 9.93 2497 795042 239455 109552305
Metabolic acidosis 142.67 9.93 317 797222 99427 109692333
Deep vein thrombosis postoperative 142.27 9.93 821 796718 58470 109733290
Cytomegalovirus infection 141.45 9.93 111 797428 54333 109737427
Thrombocytopenia 141.08 9.93 1723 795816 347162 109444598
Wound infection 140.91 9.93 1183 796356 95282 109696478
Peripheral venous disease 140.59 9.93 1064 796475 83053 109708707
Hyperglycaemia 140.14 9.93 249 797290 84841 109706919
Abortion spontaneous 138.67 9.93 552 796987 33730 109758030
Tachycardia 135.19 9.93 1017 796522 225628 109566132
Liver injury 134.67 9.93 1668 795871 148745 109643015
Sepsis 134.49 9.93 1611 795928 325735 109466025
Breast cancer stage III 134.06 9.93 1004 796535 78113 109713647
Intentional product misuse 133.89 9.93 499 797040 132405 109659355
Neuropathy peripheral 133.03 9.93 753 796786 178524 109613236
Sciatica 132.24 9.93 1128 796411 91271 109700489
Shock 132.12 9.93 115 797424 53473 109738287
Anaemia 130.29 9.93 2978 794561 544108 109247652
Hypoxia 130.00 9.93 487 797052 129028 109662732
Drug dependence 129.93 9.93 102 797437 49918 109741842
Joint effusion 126.75 9.93 385 797154 20520 109771240
Intentional self-injury 125.88 9.93 56 797483 37373 109754387
Anaphylactic shock 124.22 9.93 113 797426 51433 109740327
Poisoning 121.56 9.93 30 797509 29075 109762685
Syncope 121.18 9.93 908 796631 201628 109590132
Respiratory depression 120.70 9.93 40 797499 31961 109759799
Cognitive disorder 118.03 9.93 287 797252 87224 109704536
Hyperkalaemia 117.99 9.93 540 796999 135256 109656504
Pain in extremity 117.36 9.93 4457 793082 482661 109309099
Autoimmune disorder 116.67 9.93 841 796698 64642 109727118
Palmar-plantar erythrodysaesthesia syndrome 113.90 9.93 78 797461 40947 109750813
Seizure 112.63 9.93 1035 796504 220150 109571610
Condition aggravated 111.89 9.93 6421 791118 728415 109063345
Road traffic accident 111.71 9.93 1226 796313 106172 109685588
Fatigue 111.55 9.93 10196 787343 1205762 108585998
Gait inability 111.38 9.93 1487 796052 134889 109656871
Neurotoxicity 110.99 9.93 85 797454 42122 109749638
Ventricular tachycardia 109.74 9.93 119 797420 49890 109741870
Drug use disorder 109.05 9.93 5 797534 18069 109773691
General physical health deterioration 106.18 9.93 3907 793632 421388 109370372
Bone erosion 106.02 9.93 634 796905 45737 109746023
Disability assessment scale score increased 105.85 9.93 142 797397 4128 109787632
Encephalopathy 105.29 9.93 271 797268 80784 109710976
Foot deformity 104.62 9.93 653 796886 47827 109743933
Rash 104.57 9.93 7063 790476 813901 108977859
Sedation complication 103.97 9.93 11 797528 19844 109771916
Disseminated intravascular coagulation 103.73 9.93 87 797452 41199 109750561
Neutrophil count decreased 103.25 9.93 484 797055 120457 109671303
Joint stiffness 103.22 9.93 834 796705 66409 109725351
Dry mouth 102.42 9.93 2018 795521 197930 109593830
Product use in unapproved indication 99.87 9.93 2459 795080 444918 109346842
Tremor 99.67 9.93 954 796585 201278 109590482
Hypoaesthesia 98.45 9.93 2965 794574 311258 109480502
Blood pressure diastolic decreased 98.23 9.93 515 797024 35370 109756390
Pulmonary fibrosis 98.06 9.93 1147 796392 100895 109690865
Cerebral haemorrhage 97.47 9.93 201 797338 64767 109726993
Suicidal ideation 97.04 9.93 349 797190 93588 109698172
Lower limb fracture 96.07 9.93 897 796642 74451 109717309
Injection site reaction 95.97 9.93 1024 796515 88046 109703714
Suspected suicide 95.82 9.93 3 797536 15196 109776564
Myalgia 95.33 9.93 1084 796455 221297 109570463
Acute hepatic failure 95.18 9.93 74 797465 36394 109755366
Hepatocellular injury 94.90 9.93 136 797403 50506 109741254
Hypokalaemia 94.50 9.93 850 796689 181598 109610162
Nausea 94.06 9.93 7655 789884 1228035 108563725
Hypercholesterolaemia 94.03 9.93 1036 796503 89801 109701959
Blood creatine phosphokinase increased 93.64 9.93 246 797293 72831 109718929
No adverse event 93.52 9.93 250 797289 73589 109718171
Neuroleptic malignant syndrome 92.91 9.93 66 797473 33993 109757767
Leukopenia 92.38 9.93 660 796879 148131 109643629
Restlessness 92.31 9.93 165 797374 56094 109735666
Psoriasis 91.65 9.93 1469 796070 138524 109653236
Enthesopathy 90.39 9.93 245 797294 12233 109779527
Mydriasis 90.30 9.93 24 797515 22133 109769627
Dehydration 90.28 9.93 1444 796095 278067 109513693
Adverse event 89.50 9.93 1188 796351 107621 109684139
Heart rate decreased 89.44 9.93 952 796587 81804 109709956
Orthostatic hypotension 87.20 9.93 220 797319 66029 109725731
Cardiac failure congestive 86.53 9.93 685 796854 150315 109641445
Chest discomfort 86.13 9.93 819 796720 173029 109618731
Dry skin 86.02 9.93 441 797098 107212 109684548
Atrial fibrillation 85.40 9.93 1154 796385 228488 109563272
Osteoporosis 85.24 9.93 983 796556 86169 109705591
Aspergillus infection 85.09 9.93 39 797500 25577 109766183
Adjustment disorder with depressed mood 84.87 9.93 575 796964 43308 109748452
Polyarthritis 84.60 9.93 315 797224 18648 109773112
Sleep disorder 83.73 9.93 1949 795590 196695 109595065
Dislocation of vertebra 83.44 9.93 571 796968 43150 109748610
Disturbance in attention 82.28 9.93 205 797334 61790 109729970
Blood creatinine increased 81.35 9.93 884 796655 182005 109609755
Vision blurred 81.22 9.93 570 796969 128452 109663308
Post transplant lymphoproliferative disorder 80.86 9.93 9 797530 15604 109776156
Cholestasis 80.54 9.93 220 797319 64298 109727462
Myocardial infarction 79.72 9.93 943 796596 191140 109600620
Blood glucose increased 79.71 9.93 593 796946 131903 109659857
Hallucination 79.64 9.93 418 797121 101014 109690746
Joint destruction 79.41 9.93 215 797324 10728 109781032
Platelet count decreased 79.33 9.93 1176 796363 229267 109562493
Wrong technique in product usage process 79.09 9.93 342 797197 87006 109704754
Rheumatoid nodule 79.05 9.93 323 797216 19973 109771787
Drug withdrawal syndrome 78.68 9.93 95 797444 37959 109753801
Aggression 78.42 9.93 196 797343 59014 109732746
Juvenile idiopathic arthritis 78.39 9.93 149 797390 5858 109785902
Venoocclusive liver disease 78.17 9.93 9 797530 15198 109776562
Cerebral infarction 78.09 9.93 160 797379 51678 109740082
Night sweats 77.86 9.93 1379 796160 132604 109659156
Therapy partial responder 77.18 9.93 92 797447 36969 109754791
Thrombotic microangiopathy 76.26 9.93 59 797480 29090 109762670
Proteinuria 75.45 9.93 107 797432 39911 109751849
Psychotic disorder 75.23 9.93 159 797380 50778 109740982
Accidental exposure to product 74.78 9.93 155 797384 49853 109741907
C-reactive protein 74.73 9.93 423 797116 29908 109761852
Skin exfoliation 74.68 9.93 351 797188 87300 109704460
Ascites 74.25 9.93 380 797159 92428 109699332
Withdrawal syndrome 74.18 9.93 70 797469 31310 109760450
Myoclonus 74.11 9.93 77 797462 32921 109758839
Respiratory distress 73.74 9.93 252 797287 68622 109723138
Onychomadesis 73.73 9.93 573 796966 45090 109746670
Hypothermia 73.03 9.93 50 797489 26252 109765508
Temperature regulation disorder 72.91 9.93 5 797534 12821 109778939
Pulmonary alveolar haemorrhage 72.88 9.93 27 797512 20123 109771637
Akathisia 72.72 9.93 17 797522 17096 109774664
Forced expiratory volume decreased 72.45 9.93 6 797533 13170 109778590
Pathogen resistance 72.29 9.93 19 797520 17653 109774107
Dysphagia 71.73 9.93 734 796805 152866 109638894
Posterior reversible encephalopathy syndrome 71.64 9.93 83 797456 33778 109757982
Ejection fraction decreased 71.57 9.93 115 797424 40765 109750995
Anaphylactic reaction 71.44 9.93 506 797033 113794 109677966
Disorientation 71.38 9.93 265 797274 70406 109721354
Diabetic ketoacidosis 71.14 9.93 121 797418 41937 109749823
Torsade de pointes 71.13 9.93 37 797502 22563 109769197
Drug level increased 70.43 9.93 149 797390 47570 109744190
Exposure to toxic agent 70.31 9.93 6 797533 12852 109778908
Bronchopulmonary aspergillosis 70.15 9.93 67 797472 29796 109761964
Gamma-glutamyltransferase increased 70.02 9.93 218 797321 61091 109730669
Blood pressure diastolic increased 69.87 9.93 295 797244 18512 109773248
BK virus infection 69.30 9.93 7 797532 13099 109778661
Onychomycosis 69.29 9.93 496 797043 38035 109753725
Dysarthria 69.26 9.93 341 797198 83780 109707980
Miosis 69.18 9.93 36 797503 21947 109769813
Cytomegalovirus infection reactivation 69.00 9.93 23 797516 18310 109773450
Loss of consciousness 68.88 9.93 998 796541 195308 109596452
Extrapyramidal disorder 68.70 9.93 64 797475 28803 109762957
White blood cell count decreased 67.56 9.93 1205 796334 228185 109563575
Blepharospasm 67.44 9.93 648 796891 54203 109737557
Unresponsive to stimuli 67.21 9.93 235 797304 63555 109728205
Disease recurrence 66.72 9.93 220 797319 60564 109731196
Tenosynovitis 66.51 9.93 263 797276 16020 109775740
Caesarean section 66.28 9.93 235 797304 13582 109778178
Acute respiratory distress syndrome 65.95 9.93 182 797357 53016 109738744
Creatinine renal clearance decreased 65.35 9.93 38 797501 21777 109769983
Substance abuse 65.02 9.93 7 797532 12456 109779304
Body temperature decreased 65.00 9.93 473 797066 36462 109755298
Asphyxia 64.78 9.93 12 797527 14203 109777557
Abnormal behaviour 64.49 9.93 114 797425 38925 109752835
Haemoptysis 64.22 9.93 280 797259 71074 109720686
Haematotoxicity 64.18 9.93 36 797503 21046 109770714
Cardiogenic shock 63.99 9.93 206 797333 57132 109734628
Brain oedema 63.90 9.93 78 797461 31020 109760740
Immune reconstitution inflammatory syndrome 63.48 9.93 19 797520 16207 109775553
Laryngitis 63.46 9.93 523 797016 41888 109749872
Finger deformity 63.03 9.93 432 797107 32660 109759100
Acute graft versus host disease 62.89 9.93 9 797530 12872 109778888
Dyspnoea 62.79 9.93 7007 790532 1099865 108691895
Lung disorder 62.43 9.93 1721 795818 178326 109613434
Balance disorder 62.13 9.93 539 797000 116021 109675739
Joint laxity 61.58 9.93 83 797456 2424 109789336
Melaena 60.56 9.93 272 797267 68485 109723275
Arrhythmia 60.22 9.93 277 797262 69298 109722462
Interstitial lung disease 60.16 9.93 678 796861 138656 109653104
Clostridium difficile colitis 59.48 9.93 143 797396 43635 109748125
Pulmonary oedema 59.36 9.93 453 797086 100206 109691554
Ventricular fibrillation 59.31 9.93 131 797408 41182 109750578
Loss of personal independence in daily activities 59.28 9.93 1459 796080 148561 109643199
X-ray abnormal 59.17 9.93 474 797065 37643 109754117
Wheezing 59.16 9.93 2326 795213 252904 109538856
Oedema 59.06 9.93 1956 795583 208020 109583740
Status epilepticus 58.94 9.93 85 797454 31486 109760274
Hemiplegia 58.48 9.93 47 797492 22735 109769025
Irritability 58.20 9.93 165 797374 47644 109744116
Exostosis 58.03 9.93 546 796993 45410 109746350
Mucormycosis 58.00 9.93 5 797534 10623 109781137
Coagulopathy 57.70 9.93 131 797408 40780 109750980
Ear infection 57.56 9.93 699 796840 62033 109729727
Aphasia 57.15 9.93 225 797314 58772 109732988
Blood bilirubin increased 56.92 9.93 318 797221 75654 109716106
Lupus-like syndrome 56.79 9.93 495 797044 40297 109751463
Localised infection 56.65 9.93 516 797023 42532 109749228
Second primary malignancy 56.25 9.93 30 797509 18038 109773722
Eosinophilia 56.09 9.93 221 797318 57715 109734045
Personality disorder 56.06 9.93 12 797527 12825 109778935
Exposure via skin contact 55.99 9.93 13 797526 13134 109778626
Dystonia 55.96 9.93 62 797477 25743 109766017
Pancreatitis acute 55.79 9.93 234 797305 60040 109731720
Tachypnoea 55.68 9.93 126 797413 39269 109752491
Anti-cyclic citrullinated peptide antibody 55.67 9.93 288 797251 19676 109772084
Gestational diabetes 55.46 9.93 147 797392 7242 109784518
Nail disorder 55.11 9.93 650 796889 57285 109734475
Rebound effect 54.98 9.93 19 797520 14787 109776973
Inappropriate antidiuretic hormone secretion 54.89 9.93 100 797439 33751 109758009
Neurologic neglect syndrome 54.74 9.93 3 797536 9295 109782465
Retinitis 54.62 9.93 410 797129 31917 109759843
Graft versus host disease 54.59 9.93 34 797505 18772 109772988
Septic shock 54.51 9.93 803 796736 156725 109635035
Psychomotor hyperactivity 54.39 9.93 40 797499 20237 109771523
Tumour lysis syndrome 53.59 9.93 87 797452 30714 109761046
Bronchospasm 53 9.93 85 797454 30154 109761606
Diarrhoea 52.74 9.93 7309 790230 1132196 108659564
Dyskinesia 52.56 9.93 192 797347 51254 109740506
Graft versus host disease in gastrointestinal tract 52.47 9.93 3 797536 8965 109782795
Transplant rejection 52.21 9.93 60 797479 24507 109767253
Speech disorder 52.18 9.93 247 797292 61322 109730438
Unintentional medical device removal 52.16 9.93 3 797536 8920 109782840
Stevens-Johnson syndrome 52.00 9.93 169 797370 46732 109745028
Device difficult to use 51.88 9.93 36 797503 18769 109772991
Basal cell carcinoma 51.85 9.93 527 797012 44743 109747017
Prescribed overdose 51.43 9.93 903 796636 86678 109705082
Haemophagocytic lymphohistiocytosis 51.37 9.93 93 797446 31466 109760294
Lupus vulgaris 51.32 9.93 419 797120 33464 109758296
Osteonecrosis of jaw 51.19 9.93 176 797363 47841 109743919
COVID-19 50.34 9.93 1363 796176 243697 109548063
Hypomagnesaemia 50.11 9.93 244 797295 60126 109731634
Drug dose omission by device 49.96 9.93 21 797518 14495 109777265
Cytopenia 49.70 9.93 88 797451 30028 109761732
Hepatic cirrhosis 49.39 9.93 723 796816 66903 109724857
Angina pectoris 49.30 9.93 256 797283 62039 109729721
Maternal exposure timing unspecified 49.12 9.93 289 797250 20724 109771036
Blood alkaline phosphatase increased 48.86 9.93 305 797234 70630 109721130
Acute respiratory failure 48.59 9.93 330 797209 74930 109716830
Mental status changes 48.54 9.93 335 797204 75787 109715973
Mania 48.45 9.93 47 797492 20749 109771011
Dermatitis atopic 48.44 9.93 68 797471 25473 109766287
Palpitations 48.26 9.93 832 796707 158380 109633380
Chronic kidney disease 48.03 9.93 337 797202 75954 109715806
Hypothyroidism 47.89 9.93 318 797221 72581 109719179
Cytomegalovirus viraemia 47.70 9.93 35 797504 17729 109774031
Joint dislocation 47.65 9.93 415 797124 33775 109757985
Haemorrhage intracranial 47.49 9.93 85 797454 28884 109762876
Hallucination, visual 47.25 9.93 138 797401 39467 109752293
Polyomavirus-associated nephropathy 47.20 9.93 3 797536 8198 109783562
Blood calcium decreased 47.20 9.93 119 797420 35726 109756034
Gastrointestinal haemorrhage 46.99 9.93 875 796664 164643 109627117
Acute graft versus host disease in skin 46.99 9.93 10 797529 10730 109781030
Adenovirus infection 46.56 9.93 11 797528 10983 109780777
Prescribed underdose 46.50 9.93 694 796845 64480 109727280
Carotid artery thrombosis 46.44 9.93 7 797532 9631 109782129
Acute chest syndrome 46.23 9.93 66 797473 2037 109789723
Face oedema 45.73 9.93 109 797430 33360 109758400
Red blood cell sedimentation rate 45.68 9.93 110 797429 5104 109786656
Lymphocyte count decreased 45.44 9.93 235 797304 57008 109734752
Rash maculo-papular 45.20 9.93 331 797208 73891 109717869
Agranulocytosis 44.93 9.93 261 797278 61499 109730261
Metastases to bone 44.61 9.93 100 797439 31272 109760488
Muscle twitching 44.57 9.93 93 797446 29842 109761918
Rash erythematous 44.23 9.93 377 797162 81455 109710305
Maternal exposure before pregnancy 44.23 9.93 134 797405 7131 109784629
Coordination abnormal 44.14 9.93 71 797468 25157 109766603
Metastases to central nervous system 44.03 9.93 60 797479 22757 109769003
Back injury 43.85 9.93 529 797010 46870 109744890
Acute generalised exanthematous pustulosis 43.82 9.93 55 797484 21609 109770151
Migraine 43.75 9.93 1581 795958 170071 109621689
Bradyphrenia 43.64 9.93 15 797524 11713 109780047
Muscle rigidity 43.60 9.93 66 797473 23965 109767795
Hemiparesis 43.44 9.93 166 797373 43737 109748023
Paradoxical drug reaction 43.24 9.93 9 797530 9808 109781952
Metastases to liver 43.17 9.93 122 797417 35264 109756496
Tendonitis 43.05 9.93 329 797210 25754 109766006
Urinary retention 42.80 9.93 310 797229 69373 109722387
Leukocytosis 42.71 9.93 221 797318 53607 109738153
Hyperbilirubinaemia 42.61 9.93 99 797440 30572 109761188
Wheelchair user 42.56 9.93 139 797400 7703 109784057
Cerebrovascular accident 42.15 9.93 990 796549 180294 109611466
Bacteraemia 42.13 9.93 160 797379 42230 109749530
Drug tolerance decreased 41.95 9.93 341 797198 27199 109764561
Pyrexia 41.80 9.93 5759 791780 892506 108899254
Acidosis 41.73 9.93 61 797478 22470 109769290
Toxic epidermal necrolysis 41.66 9.93 239 797300 56488 109735272
Injection site erythema 41.52 9.93 930 796609 93246 109698514
Ischaemic stroke 41.49 9.93 155 797384 41108 109750652
Blood pressure decreased 41.46 9.93 582 796957 114509 109677251
Toxic skin eruption 41.38 9.93 85 797454 27430 109764330
Erythema multiforme 41.19 9.93 55 797484 21042 109770718
Pleural effusion 41.17 9.93 971 796568 176738 109615022
Multiple-drug resistance 41.17 9.93 22 797517 13213 109778547
Parkinsonism 41.16 9.93 60 797479 22127 109769633
Tongue disorder 41.08 9.93 208 797331 14090 109777670
Hyperthermia 40.98 9.93 56 797483 21216 109770544
Emotional distress 40.96 9.93 175 797364 44672 109747088
Flushing 40.86 9.93 521 797018 104215 109687545
Cardiotoxicity 40.68 9.93 37 797502 16844 109774916
Pneumonia aspiration 40.51 9.93 382 797157 80851 109710909
Pulmonary embolism 40.46 9.93 1207 796332 213267 109578493
Hepatotoxicity 40.43 9.93 279 797260 63121 109728639
Sinus tachycardia 40.40 9.93 174 797365 44319 109747441
Alanine aminotransferase abnormal 39.94 9.93 153 797386 9181 109782579
Generalised tonic-clonic seizure 39.82 9.93 231 797308 54449 109737311
Chronic graft versus host disease 39.01 9.93 10 797529 9447 109782313
Glycosylated haemoglobin increased 38.99 9.93 69 797470 23550 109768210
Nodule 38.89 9.93 383 797156 32248 109759512
Myocarditis 38.63 9.93 101 797438 29954 109761806
Shock haemorrhagic 38.62 9.93 87 797452 27160 109764600
Disability 38.62 9.93 360 797179 29863 109761897
Electrocardiogram QRS complex prolonged 38.55 9.93 23 797516 12998 109778762
Cardiomyopathy 38.43 9.93 119 797420 33406 109758354
Neck deformity 38.28 9.93 57 797482 1829 109789931
Injection site pruritus 38.22 9.93 550 796989 50708 109741052
Premature labour 38.15 9.93 149 797390 9023 109782737
Obstructive airways disorder 38.03 9.93 187 797352 45962 109745798
Coronary artery disease 37.98 9.93 332 797207 71358 109720402
Haemorrhage 37.91 9.93 541 796998 106151 109685609
Pseudomonas infection 37.82 9.93 91 797448 27762 109763998
Fracture 37.79 9.93 307 797232 24481 109767279
Epstein-Barr virus infection 37.46 9.93 48 797491 18690 109773070
Tardive dyskinesia 37.45 9.93 26 797513 13553 109778207
Fear 37.17 9.93 69 797470 23124 109768636
Schizophrenia 36.72 9.93 63 797476 21763 109769997
Ankylosing spondylitis 36.68 9.93 215 797324 15397 109776363
Premature rupture of membranes 36.59 9.93 94 797445 4543 109787217
Acute myocardial infarction 36.41 9.93 407 797132 83370 109708390
Hepatic encephalopathy 36.28 9.93 95 797444 28161 109763599
Synovial cyst 36.22 9.93 171 797368 11259 109780501
Depressed mood 36.16 9.93 273 797266 60536 109731224
Procedural pain 36.15 9.93 133 797406 35432 109756328
Diabetes insipidus 36.10 9.93 3 797536 6567 109785193
Vomiting 36.07 9.93 5894 791645 904781 108886979
Latent tuberculosis 36.03 9.93 85 797454 3892 109787868
Haematoma 35.98 9.93 260 797279 58216 109733544
Colitis 35.95 9.93 520 797019 101803 109689957
Femur fracture 35.92 9.93 484 797055 43985 109747775
Haemodynamic instability 35.89 9.93 69 797470 22819 109768941
Conjunctivitis allergic 35.88 9.93 4 797535 6927 109784833
Acute myeloid leukaemia 35.86 9.93 147 797392 37963 109753797
Eating disorder 35.75 9.93 109 797430 30749 109761011
Cardiac failure acute 35.69 9.93 75 797464 24003 109767757
Aspartate aminotransferase increased 35.64 9.93 879 796660 159057 109632703
Graft versus host disease in skin 35.47 9.93 8 797531 8246 109783514
Skin haemorrhage 35.42 9.93 79 797460 24748 109767012
Motor dysfunction 35.36 9.93 77 797462 24329 109767431
Subdural haematoma 35.32 9.93 139 797400 36315 109755445
Klebsiella infection 35.30 9.93 56 797483 19953 109771807
Potentiating drug interaction 35.28 9.93 20 797519 11623 109780137
Ileus 35.27 9.93 109 797430 30620 109761140
Smear cervix abnormal 35.06 9.93 67 797472 2645 109789115
Hyperuricaemia 34.84 9.93 32 797507 14499 109777261
Tenderness 34.83 9.93 345 797194 29092 109762668
Nocardiosis 34.81 9.93 6 797533 7480 109784280
Multiple sclerosis relapse 34.61 9.93 216 797323 50024 109741736
Anuria 34.28 9.93 78 797461 24263 109767497
Stress cardiomyopathy 34.25 9.93 38 797501 15768 109775992
Cystitis haemorrhagic 34.18 9.93 23 797516 12186 109779574
Spinal stenosis 34.09 9.93 245 797294 18811 109772949
Device expulsion 33.77 9.93 112 797427 30779 109760981
Liver function test increased 33.73 9.93 857 796682 87691 109704069
Fluid retention 33.57 9.93 478 797061 93829 109697931
Bone pain 33.46 9.93 304 797235 64829 109726931
Seronegative arthritis 33.28 9.93 185 797354 12992 109778768
Blood parathyroid hormone decreased 33.21 9.93 184 797355 12905 109778855
Hyperammonaemia 33.21 9.93 30 797509 13702 109778058
Glomerular filtration rate decreased 33.03 9.93 103 797436 28853 109762907
Polyneuropathy 33.01 9.93 119 797420 31893 109759867
Jaundice cholestatic 32.90 9.93 34 797505 14574 109777186
Jaundice 32.87 9.93 271 797268 58965 109732795
Candida infection 32.76 9.93 207 797332 47802 109743958
Hepatitis B reactivation 32.68 9.93 7 797532 7477 109784283
Dissociation 32.67 9.93 15 797524 9827 109781933
Tuberculosis 32.65 9.93 230 797309 17544 109774216
Immune effector cell-associated neurotoxicity syndrome 32.63 9.93 35 797504 14747 109777013
Nephropathy toxic 32.60 9.93 96 797443 27382 109764378
Neck pain 32.58 9.93 1139 796400 121991 109669769
Respiratory acidosis 32.50 9.93 31 797508 13795 109777965
Arthritis infective 32.30 9.93 155 797384 10274 109781486
Dust allergy 32.27 9.93 3 797536 5998 109785762
Oliguria 32.18 9.93 53 797486 18604 109773156
Sinus bradycardia 32.15 9.93 107 797432 29376 109762384
Scleritis 32.09 9.93 99 797440 5321 109786439
Mental disorder 32.07 9.93 157 797382 38634 109753126
Adjustment disorder 32.06 9.93 19 797520 10776 109780984
Feeling abnormal 31.64 9.93 1027 796512 179684 109612076
Metastases to lung 31.60 9.93 75 797464 22988 109768772
Sexual dysfunction 31.58 9.93 11 797528 8519 109783241
Labelled drug-drug interaction medication error 31.51 9.93 107 797432 29195 109762565
Pneumothorax 31.42 9.93 139 797400 35146 109756614
Neck mass 31.33 9.93 91 797448 4730 109787030
Pemphigoid 31.26 9.93 59 797480 19648 109772112
Product prescribing error 31.21 9.93 229 797310 51102 109740658
Blood lactic acid increased 31.14 9.93 41 797498 15780 109775980
Euglycaemic diabetic ketoacidosis 31.08 9.93 23 797516 11600 109780160
Pulmonary vasculitis 31.07 9.93 5 797534 6555 109785205
Chills 31.06 9.93 1093 796446 189487 109602273
Cyanosis 31.04 9.93 110 797429 29631 109762129
Acute coronary syndrome 31.00 9.93 76 797463 23036 109768724
Granuloma skin 30.93 9.93 162 797377 11121 109780639
Pre-eclampsia 30.84 9.93 134 797405 8516 109783244
Multiple fractures 30.74 9.93 137 797402 8803 109782957
Enterocolitis 30.70 9.93 56 797483 18893 109772867
Febrile bone marrow aplasia 30.70 9.93 49 797490 17416 109774344
Limb deformity 30.67 9.93 77 797462 3669 109788091
Food allergy 30.53 9.93 61 797478 19887 109771873
Generalised oedema 30.44 9.93 116 797423 30588 109761172
Hypernatraemia 30.44 9.93 51 797488 17782 109773978
Antinuclear antibody positive 30.40 9.93 139 797400 9029 109782731
Infective pulmonary exacerbation of cystic fibrosis 30.40 9.93 37 797502 14734 109777026
Liver disorder 30.33 9.93 1285 796254 140958 109650802
Cardiac failure chronic 30.15 9.93 33 797506 13778 109777982
Colorectal cancer 30.08 9.93 14 797525 9100 109782660
Device use error 29.94 9.93 14 797525 9075 109782685
Pneumatosis intestinalis 29.90 9.93 12 797527 8517 109783243
Lip swelling 29.88 9.93 228 797311 50439 109741321
Hypoalbuminaemia 29.68 9.93 108 797431 28866 109762894
Lethargy 29.66 9.93 485 797054 93091 109698669
Mouth ulceration 29.59 9.93 500 797039 47638 109744122
Pulseless electrical activity 29.47 9.93 47 797492 16710 109775050
Hallucination, auditory 29.34 9.93 95 797444 26302 109765458
Erythema 29.34 9.93 1761 795778 289686 109502074
Rotator cuff repair 29.31 9.93 56 797483 2210 109789550
Device leakage 29.18 9.93 44 797495 16004 109775756
Pulmonary haemorrhage 29.08 9.93 46 797493 16410 109775350
Hepatitis acute 29.05 9.93 57 797482 18709 109773051
Delusion 28.90 9.93 82 797457 23673 109768087
Hypomania 28.90 9.93 19 797520 10191 109781569
Blood urea increased 28.89 9.93 255 797284 54702 109737058
Device related infection 28.75 9.93 167 797372 39352 109752408
Pulmonary arterial hypertension 28.58 9.93 129 797410 32439 109759321
Vasoplegia syndrome 28.51 9.93 3 797536 5436 109786324
Hyperlactacidaemia 28.49 9.93 12 797527 8274 109783486
Malignant mediastinal neoplasm 28.47 9.93 42 797497 1336 109790424
Mite allergy 28.46 9.93 4 797535 5799 109785961
Drug tolerance 28.39 9.93 211 797328 16374 109775386
Gastroenteritis viral 28.23 9.93 347 797192 30879 109760881
Paranoia 28.14 9.93 76 797463 22298 109769462
Dermatitis acneiform 28.08 9.93 30 797509 12665 109779095
Synovial disorder 28.04 9.93 65 797474 2942 109788818
Endophthalmitis 27.92 9.93 12 797527 8175 109783585
Impaired work ability 27.65 9.93 302 797237 26117 109765643
Hepatitis cholestatic 27.50 9.93 53 797486 17513 109774247
Atrial tachycardia 27.47 9.93 16 797523 9162 109782598
Hypocalcaemia 27.45 9.93 320 797219 65046 109726714
Product label confusion 27.43 9.93 267 797272 22410 109769350
Toxic encephalopathy 27.39 9.93 42 797497 15172 109776588
Rhinitis allergic 27.26 9.93 55 797484 17867 109773893
Paralysis 27.20 9.93 44 797495 15556 109776204
Alanine aminotransferase increased 27.03 9.93 1067 796472 182706 109609054
Skin toxicity 27.02 9.93 27 797512 11756 109780004
Circulatory collapse 27.02 9.93 190 797349 42803 109748957
Pulmonary congestion 26.97 9.93 123 797416 30843 109760917
Hepatitis fulminant 26.96 9.93 14 797525 8546 109783214
Multiple drug therapy 26.93 9.93 12 797527 8002 109783758
Rheumatoid lung 26.78 9.93 80 797459 4224 109787536
Premature delivery 26.67 9.93 338 797201 30294 109761466
Joint injury 26.66 9.93 421 797118 39573 109752187
Skin ulcer 26.65 9.93 624 796915 63021 109728739
Proctitis 26.56 9.93 51 797488 16876 109774884
Panniculitis 26.53 9.93 198 797341 15384 109776376
Subarachnoid haemorrhage 26.45 9.93 117 797422 29585 109762175
Peripheral sensory neuropathy 26.40 9.93 50 797489 16630 109775130
Bladder cancer 26.23 9.93 68 797471 20224 109771536
Pneumonia bacterial 26.17 9.93 99 797440 26162 109765598
Synovial fluid analysis 26.16 9.93 59 797480 2622 109789138
Affect lability 26.02 9.93 60 797479 18577 109773183
Epistaxis 26.01 9.93 728 796811 129644 109662116
Transaminases increased 25.98 9.93 312 797227 63078 109728682
Ankle arthroplasty 25.86 9.93 57 797482 2494 109789266
International normalised ratio increased 25.79 9.93 455 797084 86317 109705443
Blood pressure increased 25.73 9.93 2181 795358 256192 109535568
Hyperpyrexia 25.71 9.93 13 797526 8056 109783704
Myopathy 25.59 9.93 93 797446 24867 109766893
Diabetes mellitus inadequate control 25.50 9.93 119 797420 29656 109762104
Diplopia 25.42 9.93 187 797352 41707 109750053
Anxiety 25.42 9.93 2142 795397 342936 109448824
Sleep terror 25.39 9.93 8 797531 6602 109785158
Diabetes mellitus 25.29 9.93 535 797004 98846 109692914
Virologic failure 25.28 9.93 3 797536 4949 109786811
Therapy non-responder 25.08 9.93 1381 796158 155926 109635834
Myocardial ischaemia 25.06 9.93 103 797436 26581 109765179
Cytomegalovirus chorioretinitis 25.04 9.93 10 797529 7118 109784642
Gangrene 24.98 9.93 50 797489 16291 109775469
Bronchitis 24.92 9.93 1378 796161 155654 109636106
Bone disorder 24.89 9.93 248 797291 20944 109770816
Pruritus genital 24.86 9.93 8 797531 6514 109785246
Cross sensitivity reaction 24.73 9.93 5 797534 5562 109786198
Sensory loss 24.71 9.93 76 797463 21381 109770379
Herpes zoster 24.69 9.93 986 796553 107393 109684367
Atrioventricular block complete 24.67 9.93 69 797470 20013 109771747
Hypogammaglobulinaemia 24.65 9.93 69 797470 20007 109771753
Immune-mediated myositis 24.65 9.93 7 797532 6179 109785581
Paraesthesia oral 24.65 9.93 142 797397 33529 109758231
Lymphopenia 24.52 9.93 179 797360 39991 109751769
Tenosynovitis stenosans 24.37 9.93 69 797470 3534 109788226
Presyncope 24.33 9.93 230 797309 48657 109743103
Progressive multifocal leukoencephalopathy 24.28 9.93 95 797444 24861 109766899
Respiration abnormal 24.24 9.93 21 797518 9788 109781972
Normal newborn 24.17 9.93 253 797286 21643 109770117
Eye pruritus 24.11 9.93 138 797401 32637 109759123
Cleft lip and palate 24.00 9.93 28 797511 704 109791056
Hypercapnia 23.99 9.93 27 797512 11132 109780628
Immune-mediated enterocolitis 23.75 9.93 23 797516 10162 109781598
Drug effective for unapproved indication 23.74 9.93 41 797498 14126 109777634
Adverse drug reaction 23.73 9.93 959 796580 104600 109687160
Kidney transplant rejection 23.66 9.93 31 797508 11956 109779804
Foot fracture 23.58 9.93 285 797254 25261 109766499
Hepatocellular carcinoma 23.40 9.93 22 797517 9858 109781902
Loose body in joint 23.39 9.93 39 797500 1381 109790379
Pancytopenia 23.39 9.93 1785 795754 207828 109583932
Visual acuity reduced 23.38 9.93 136 797403 32037 109759723
Accidental death 23.32 9.93 4 797535 5005 109786755
Affective disorder 23.30 9.93 28 797511 11213 109780547
Polyuria 23.27 9.93 59 797480 17679 109774081
Ventricular arrhythmia 23.26 9.93 23 797516 10064 109781696
Product prescribing issue 23.24 9.93 35 797504 12737 109779023
Hypophosphataemia 23.20 9.93 142 797397 33040 109758720
Strongyloidiasis 23.17 9.93 4 797535 4982 109786778
Renal tubular necrosis 23.13 9.93 127 797412 30348 109761412
Haematemesis 23.06 9.93 294 797245 58814 109732946
Hypoxic-ischaemic encephalopathy 23.03 9.93 18 797521 8829 109782931
COVID-19 pneumonia 22.92 9.93 165 797374 36978 109754782
Pericardial effusion 22.92 9.93 283 797256 56934 109734826
Acute pulmonary oedema 22.71 9.93 56 797483 16940 109774820
Product administered to patient of inappropriate age 22.68 9.93 15 797524 8021 109783739
Exposure via ingestion 22.62 9.93 4 797535 4896 109786864
Hydrops foetalis 22.54 9.93 28 797511 753 109791007
Skin papilloma 22.46 9.93 104 797435 6792 109784968
Gastric haemorrhage 22.41 9.93 51 797488 15864 109775896
Walking aid user 22.39 9.93 278 797261 24797 109766963
Poor venous access 22.39 9.93 273 797266 24249 109767511
Vaginal flatulence 22.37 9.93 33 797506 12111 109779649
Postoperative wound infection 22.36 9.93 192 797347 15561 109776199
Amyloid arthropathy 22.33 9.93 42 797497 1638 109790122
Blood lactate dehydrogenase increased 22.31 9.93 208 797331 44126 109747634
Nasal polyps 22.30 9.93 38 797501 13162 109778598
Body tinea 22.28 9.93 48 797491 2067 109789693
Atrioventricular block 22.24 9.93 56 797483 16821 109774939
Nasal oedema 22.17 9.93 103 797436 6736 109785024
Product administration error 22.17 9.93 167 797372 37050 109754710
Venoocclusive disease 22.15 9.93 9 797530 6341 109785419
Ketoacidosis 22.13 9.93 24 797515 10063 109781697
Nail operation 22.08 9.93 42 797497 1652 109790108
Acute myeloid leukaemia recurrent 22.05 9.93 5 797534 5134 109786626
Radiculopathy 21.90 9.93 69 797470 19267 109772493
Oral herpes 21.90 9.93 374 797165 35706 109756054
Hyperprolactinaemia 21.85 9.93 10 797529 6565 109785195
Pulmonary hypertension 21.79 9.93 274 797265 54946 109736814
Blindness 21.73 9.93 163 797376 36196 109755564
Palmoplantar keratoderma 21.64 9.93 6 797533 5381 109786379
Product preparation error 21.61 9.93 28 797511 10851 109780909
Transplant dysfunction 21.60 9.93 17 797522 8311 109783449
Type 1 diabetes mellitus 21.60 9.93 20 797519 9027 109782733
Spondylitis 21.58 9.93 148 797391 11190 109780570
Ultrasound antenatal screen 21.49 9.93 26 797513 680 109791080
Immunosuppressant drug level increased 21.46 9.93 32 797507 11692 109780068
Acute graft versus host disease in intestine 21.35 9.93 7 797532 5632 109786128
Human antichimeric antibody positive 21.25 9.93 42 797497 1700 109790060
Bradykinesia 21.19 9.93 28 797511 10760 109781000
Sleep disorder due to a general medical condition 21.16 9.93 257 797282 51855 109739905
Mucocutaneous ulceration 21.12 9.93 27 797512 748 109791012
Renal injury 21.04 9.93 67 797472 18646 109773114
Fracture delayed union 20.99 9.93 48 797491 2153 109789607
Dyspepsia 20.94 9.93 1624 795915 189341 109602419
Ulcer haemorrhage 20.92 9.93 252 797287 22319 109769441
Right ventricular failure 20.91 9.93 106 797433 25848 109765912
Ventricular extrasystoles 20.89 9.93 88 797451 22553 109769207
Vascular device infection 20.83 9.93 56 797483 16456 109775304
Bradypnoea 20.79 9.93 19 797520 8630 109783130
Hypertransaminasaemia 20.73 9.93 97 797442 24158 109767602
Systemic inflammatory response syndrome 20.73 9.93 39 797500 13004 109778756
Oropharyngeal pain 20.66 9.93 1183 796356 134093 109657667
Epilepsy 20.63 9.93 902 796637 99307 109692453
Capillary leak syndrome 20.61 9.93 5 797534 4903 109786857
Salivary hypersecretion 20.57 9.93 61 797478 17360 109774400
Bacterial sepsis 20.54 9.93 27 797512 10399 109781361
Dyspnoea exertional 20.52 9.93 582 796957 103478 109688282
Acute lymphocytic leukaemia recurrent 20.52 9.93 8 797531 5779 109785981
Chronic sinusitis 20.46 9.93 102 797437 24982 109766778
Human herpesvirus 6 infection 20.38 9.93 11 797528 6570 109785190
Amylase increased 20.28 9.93 37 797502 12482 109779278
Hypertriglyceridaemia 20.22 9.93 55 797484 16099 109775661
Dysgeusia 20.16 9.93 369 797170 69616 109722144
Joint noise 20.15 9.93 82 797457 5061 109786699
Vascular stent thrombosis 20.10 9.93 3 797536 4158 109787602
Foot operation 20.04 9.93 105 797434 7208 109784552
Anti-neutrophil cytoplasmic antibody positive vasculitis 20.03 9.93 7 797532 5410 109786350
Bone density decreased 19.95 9.93 190 797349 15852 109775908
Fear of injection 19.83 9.93 121 797418 8790 109782970
Product dose omission issue 19.74 9.93 2025 795514 319757 109472003
Haematuria 19.64 9.93 452 797087 82553 109709207
Ileus paralytic 19.63 9.93 34 797505 11703 109780057
Full blood count abnormal 19.63 9.93 285 797254 55767 109735993
Oesophageal carcinoma 19.63 9.93 33 797506 11491 109780269
Infection susceptibility increased 19.57 9.93 73 797466 4325 109787435
Dysphonia 19.54 9.93 408 797131 75521 109716239
Intervertebral disc degeneration 19.51 9.93 208 797331 17877 109773883
Systemic candida 19.47 9.93 26 797513 9948 109781812
Pain in jaw 19.43 9.93 256 797283 50921 109740839
Hypertension 19.41 9.93 4062 793477 506022 109285738
Lymphatic fistula 19.41 9.93 37 797502 1458 109790302
Abdominal pain upper 19.39 9.93 2836 794703 346275 109445485
Linear IgA disease 19.38 9.93 4 797535 4385 109787375
Incoherent 19.34 9.93 19 797520 8339 109783421
Hydrocephalus 19.30 9.93 28 797511 10347 109781413
Breast cancer stage I 19.26 9.93 15 797524 7372 109784388
Arterial occlusive disease 19.25 9.93 52 797487 15256 109776504
Ingrown hair 19.22 9.93 26 797513 762 109790998
Anosmia 19.21 9.93 38 797501 12434 109779326
Heparin-induced thrombocytopenia 19.20 9.93 33 797506 11391 109780369
Femoral hernia incarcerated 19.16 9.93 37 797502 1472 109790288
Laryngospasm 19.13 9.93 5 797534 4663 109787097
Brain injury 19.12 9.93 43 797496 13433 109778327
Trisomy 18 19.11 9.93 23 797516 598 109791162
Neurological symptom 18.90 9.93 54 797485 15554 109776206
Metastasis 18.89 9.93 19 797520 8248 109783512
Congestive cardiomyopathy 18.88 9.93 47 797492 14172 109777588
Lipase increased 18.86 9.93 70 797469 18602 109773158
Therapeutic response decreased 18.85 9.93 864 796675 95635 109696125
Psychiatric decompensation 18.80 9.93 9 797530 5756 109786004
Foetal exposure during pregnancy 18.71 9.93 105 797434 7400 109784360
Deep vein thrombosis 18.71 9.93 821 796718 139066 109652694
Hypotonia 18.68 9.93 55 797484 15690 109776070
Female genital tract fistula 18.67 9.93 59 797480 16460 109775300
Vertigo 18.66 9.93 480 797059 86390 109705370
Hypophagia 18.64 9.93 267 797272 52359 109739401
Therapy interrupted 18.63 9.93 250 797289 49572 109742188
Mucosal inflammation 18.63 9.93 539 797000 95602 109696158
Colitis ulcerative 18.60 9.93 708 796831 76655 109715105
Prostatic specific antigen increased 18.52 9.93 39 797500 12472 109779288
Depressive symptom 18.48 9.93 20 797519 8394 109783366
Skin cancer 18.47 9.93 203 797336 17581 109774179
Ulcer 18.44 9.93 424 797115 42692 109749068
Post procedural infection 18.41 9.93 166 797373 13643 109778117
Immune-mediated hepatitis 18.31 9.93 13 797526 6698 109785062
Complications of transplanted kidney 18.31 9.93 16 797523 7426 109784334
Body height below normal 18.29 9.93 44 797495 2040 109789720
Swelling face 18.29 9.93 516 797023 91805 109699955
Polyhydramnios 18.26 9.93 42 797497 1891 109789869
Wound infection pseudomonas 18.13 9.93 48 797491 2363 109789397
Eosinophil count increased 18.13 9.93 84 797455 20974 109770786
Concomitant disease aggravated 18.11 9.93 59 797480 16305 109775455
Short stature 18.10 9.93 30 797509 1057 109790703
Neuritis 18.09 9.93 16 797523 7383 109784377
Hyperthyroidism 18.05 9.93 130 797409 29131 109762629
Cholangitis 18.01 9.93 59 797480 16276 109775484
Colitis microscopic 18.00 9.93 44 797495 13350 109778410
Disturbance in social behaviour 17.92 9.93 7 797532 5051 109786709
Breast feeding 17.88 9.93 24 797515 698 109791062
Long QT syndrome 17.88 9.93 15 797524 7103 109784657
Hypervolaemia 17.85 9.93 250 797289 49210 109742550
Eosinophilic granulomatosis with polyangiitis 17.84 9.93 31 797508 10655 109781105
Methaemoglobinaemia 17.80 9.93 24 797515 9144 109782616
Sudden death 17.79 9.93 103 797436 24292 109767468
Rales 17.75 9.93 105 797434 24634 109767126
Laryngeal oedema 17.73 9.93 27 797512 9780 109781980
Hypertensive crisis 17.72 9.93 103 797436 24269 109767491
Pulmonary pain 17.70 9.93 91 797448 6202 109785558
Skin burning sensation 17.66 9.93 89 797450 21736 109770024
Pulmonary function test abnormal 17.58 9.93 7 797532 4993 109786767
Anhedonia 17.51 9.93 55 797484 15373 109776387
Metastases to lymph nodes 17.48 9.93 53 797486 14979 109776781
Personality change 17.40 9.93 33 797506 10969 109780791
Eczema 17.30 9.93 393 797146 71900 109719860
Pseudomonal sepsis 17.24 9.93 24 797515 9022 109782738
Left ventricular dysfunction 17.24 9.93 99 797440 23394 109768366
Osteopenia 17.23 9.93 240 797299 21969 109769791
Neutrophilia 17.21 9.93 30 797509 10299 109781461
Erectile dysfunction 17.20 9.93 72 797467 18484 109773276
Polydipsia 17.20 9.93 18 797521 7670 109784090
Injection site bruising 17.19 9.93 488 797051 50775 109740985
Intracranial pressure increased 17.19 9.93 31 797508 10504 109781256
Malignant melanoma 17.18 9.93 192 797347 16699 109775061
Macular degeneration 17.14 9.93 89 797450 21570 109770190
Cryptococcosis 17.10 9.93 6 797533 4625 109787135
Temperature intolerance 17.09 9.93 48 797491 13902 109777858
Taste disorder 17.08 9.93 604 796935 64783 109726977
Cyst 17.00 9.93 188 797351 16308 109775452
Maternal exposure during breast feeding 16.94 9.93 68 797471 4170 109787590
Injection site warmth 16.87 9.93 196 797343 17209 109774551
Electrolyte imbalance 16.84 9.93 178 797361 36850 109754910
Sputum discoloured 16.83 9.93 125 797414 27820 109763940
Anticholinergic syndrome 16.77 9.93 5 797534 4275 109787485
Placental disorder 16.76 9.93 28 797511 993 109790767
Nervous system disorder 16.76 9.93 147 797392 31574 109760186
Porphyria acute 16.68 9.93 208 797331 18572 109773188
Osteonecrosis 16.68 9.93 159 797380 33582 109758178
Antibody test positive 16.66 9.93 55 797484 3065 109788695
Creatinine renal clearance increased 16.65 9.93 3 797536 3622 109788138
Type I hypersensitivity 16.65 9.93 13 797526 6380 109785380
Endodontic procedure 16.49 9.93 55 797484 3081 109788679
Syringe issue 16.48 9.93 27 797512 9498 109782262
Myoglobin blood increased 16.48 9.93 5 797534 4227 109787533
Post-traumatic stress disorder 16.45 9.93 14 797525 6582 109785178
Antineutrophil cytoplasmic antibody positive 16.44 9.93 8 797531 5068 109786692
Asthenia 16.39 9.93 4572 792967 684427 109107333
Small for dates baby 16.39 9.93 22 797517 640 109791120
Blood glucose decreased 16.32 9.93 135 797404 29353 109762407
Accidental overdose 16.31 9.93 269 797270 51565 109740195
Cardiac septal defect 16.24 9.93 27 797512 954 109790806
Weight decreased 16.22 9.93 3711 793828 464346 109327414
Bacterial infection 16.15 9.93 234 797305 45802 109745958
Lower respiratory tract congestion 16.12 9.93 73 797466 4723 109787037
Confusional state 16.06 9.93 3714 793825 464966 109326794
Dyslipidaemia 16.03 9.93 60 797479 15905 109775855
Treatment noncompliance 16.02 9.93 402 797137 72588 109719172
Staphylococcal infection 15.96 9.93 383 797156 69561 109722199
Device occlusion 15.96 9.93 56 797483 15129 109776631
Stillbirth 15.93 9.93 67 797472 4197 109787563
Back pain 15.86 9.93 2390 795149 368606 109423154
Atrial flutter 15.85 9.93 106 797433 24156 109767604
Incorrect dose administered 15.84 9.93 599 796940 103042 109688718
Troponin increased 15.70 9.93 138 797401 29628 109762132
Diaphragmatic disorder 15.68 9.93 39 797500 1847 109789913
Hepatitis C 15.59 9.93 43 797496 12530 109779230
Benign ovarian tumour 15.57 9.93 18 797521 448 109791312
Infection reactivation 15.57 9.93 5 797534 4076 109787684
Eyelid oedema 15.56 9.93 57 797482 15205 109776555
Extra dose administered 15.52 9.93 41 797498 12118 109779642
Drug screen positive 15.51 9.93 14 797525 6396 109785364
End stage renal disease 15.48 9.93 91 797448 21382 109770378
Compartment syndrome 15.41 9.93 12 797527 5898 109785862
Varicella zoster virus infection 15.29 9.93 14 797525 6354 109785406
Clostridium test positive 15.26 9.93 35 797504 10858 109780902
Foetal distress syndrome 15.26 9.93 21 797518 626 109791134
Spinal osteoarthritis 15.22 9.93 217 797322 19966 109771794
Mood altered 15.19 9.93 91 797448 21284 109770476
Plasma cell myeloma recurrent 15.18 9.93 17 797522 7025 109784735
Total lung capacity increased 15.18 9.93 9 797530 5103 109786657
Bone density abnormal 15.11 9.93 62 797477 3841 109787919
Device loosening 15.06 9.93 24 797515 818 109790942
Hepatitis B 15.05 9.93 29 797510 9583 109782177
Extradural haematoma 15.02 9.93 3 797536 3366 109788394
Ear pain 14.99 9.93 496 797043 52730 109739030
Head injury 14.97 9.93 219 797320 42798 109748962
Insurance issue 14.95 9.93 34 797505 10578 109781182
Radiation inflammation 14.94 9.93 27 797512 1021 109790739
Brain natriuretic peptide increased 14.92 9.93 37 797502 11172 109780588
Epstein-Barr virus associated lymphoproliferative disorder 14.91 9.93 8 797531 4794 109786966
Panic attack 14.90 9.93 135 797404 28805 109762955
Hyperventilation 14.89 9.93 26 797513 8921 109782839
Autonomic nervous system imbalance 14.74 9.93 12 797527 5768 109785992
Gait disturbance 14.73 9.93 2254 795285 275954 109515806
Hypoglycaemic coma 14.73 9.93 11 797528 5522 109786238
Hepatic cancer 14.72 9.93 37 797502 11119 109780641
Catarrh 14.72 9.93 97 797442 7238 109784522
Cushingoid 14.71 9.93 139 797400 11573 109780187
Staphylococcal bacteraemia 14.70 9.93 66 797473 16622 109775138
Bronchial secretion retention 14.70 9.93 9 797530 5015 109786745
Bone density increased 14.65 9.93 26 797513 969 109790791
Swollen joint count 14.65 9.93 110 797429 8564 109783196
Hepatic necrosis 14.63 9.93 31 797508 9891 109781869
Steroid diabetes 14.57 9.93 10 797529 5244 109786516
Bone marrow failure 14.55 9.93 312 797227 57536 109734224
Vasculitis 14.53 9.93 177 797362 35696 109756064
Extravascular haemolysis 14.52 9.93 17 797522 429 109791331
Hypovolaemia 14.51 9.93 94 797445 21580 109770180
Infusion site reaction 14.51 9.93 193 797346 17489 109774271
Tetany 14.51 9.93 4 797535 3600 109788160
Thrombosis 14.47 9.93 638 796901 108024 109683736
Neoplasm recurrence 14.45 9.93 10 797529 5222 109786538
Multiple allergies 14.43 9.93 43 797496 12220 109779540
Sickle cell anaemia 14.43 9.93 23 797516 784 109790976
Haemorrhage in pregnancy 14.41 9.93 35 797504 1633 109790127
Intraocular pressure increased 14.40 9.93 36 797503 10840 109780920
Placental insufficiency 14.37 9.93 30 797509 1264 109790496
Epstein-Barr viraemia 14.35 9.93 4 797535 3575 109788185
Anal fissure 14.33 9.93 121 797418 9760 109782000
Enterococcal infection 14.32 9.93 87 797452 20279 109771481
Nail injury 14.30 9.93 23 797516 790 109790970
Mental impairment 14.25 9.93 100 797439 22539 109769221
Breast cancer stage II 14.24 9.93 277 797262 27098 109764662
Bradyarrhythmia 14.21 9.93 9 797530 4925 109786835
Cytomegalovirus colitis 14.20 9.93 18 797521 7043 109784717
Nervousness 14.12 9.93 184 797355 36667 109755093
Genital haemorrhage 14.06 9.93 19 797520 7233 109784527
Lower gastrointestinal haemorrhage 14.05 9.93 77 797462 18409 109773351
Injection site swelling 14.03 9.93 562 796977 61228 109730532
Obsessive-compulsive disorder 14.01 9.93 19 797520 7222 109784538
Ligament rupture 14.00 9.93 62 797477 3973 109787787
Wrong product administered 13.96 9.93 37 797502 10923 109780837
Accidental exposure to product by child 13.94 9.93 3 797536 3195 109788565
Swollen tongue 13.92 9.93 330 797209 60032 109731728
Complication of device removal 13.91 9.93 8 797531 4612 109787148
Hypoventilation 13.90 9.93 23 797516 8058 109783702
Central nervous system mass 13.87 9.93 23 797516 811 109790949
Nightmare 13.82 9.93 197 797342 38666 109753094
Hallucinations, mixed 13.81 9.93 26 797513 8667 109783093
Retinal haemorrhage 13.74 9.93 30 797509 9471 109782289
Renal cancer 13.74 9.93 48 797491 12986 109778774
Wall motion score index abnormal 13.72 9.93 23 797516 818 109790942
Mitral valve incompetence 13.67 9.93 164 797375 33165 109758595
Lip oedema 13.66 9.93 21 797518 7579 109784181
Acute lung injury 13.65 9.93 3 797536 3148 109788612
Troponin T increased 13.63 9.93 7 797532 4299 109787461
Cerebral toxoplasmosis 13.59 9.93 3 797536 3139 109788621
Pharyngeal swelling 13.58 9.93 43 797496 11989 109779771
Haematocrit decreased 13.58 9.93 595 796944 65522 109726238
Lacrimal disorder 13.56 9.93 18 797521 518 109791242
Drooling 13.55 9.93 19 797520 7120 109784640
Lymph gland infection 13.54 9.93 20 797519 637 109791123
Behaviour disorder 13.51 9.93 31 797508 9616 109782144
Blood folate increased 13.49 9.93 19 797520 579 109791181
Pancreatic steatosis 13.42 9.93 36 797503 1786 109789974
Dysuria 13.42 9.93 331 797208 59900 109731860
Gastric cancer 13.39 9.93 38 797501 10970 109780790
Immune thrombocytopenia 13.37 9.93 101 797438 22393 109769367
Induced labour 13.36 9.93 24 797515 903 109790857
Coeliac disease 13.36 9.93 407 797132 42780 109748980
Delayed graft function 13.35 9.93 7 797532 4250 109787510
Reversible cerebral vasoconstriction syndrome 13.29 9.93 9 797530 4752 109787008
Granulocyte count decreased 13.28 9.93 6 797533 3968 109787792
Cervical incompetence 13.27 9.93 18 797521 529 109791231
Productive cough 13.27 9.93 681 796858 113624 109678136
Upper gastrointestinal haemorrhage 13.24 9.93 268 797271 49828 109741932
Tumour haemorrhage 13.24 9.93 11 797528 5234 109786526
Nephrotic syndrome 13.23 9.93 53 797486 13778 109777982
Blood loss anaemia 13.20 9.93 76 797463 17949 109773811
Plasma cell myeloma 13.18 9.93 349 797190 62587 109729173
Cough 13.18 9.93 3038 794501 458603 109333157
Lymphoedema 13.18 9.93 59 797480 14870 109776890
Pseudomembranous colitis 13.16 9.93 16 797523 6375 109785385
Abortion incomplete 13.16 9.93 3 797536 3069 109788691
Hand fracture 13.15 9.93 102 797437 8020 109783740
Heart rate irregular 13.13 9.93 332 797207 33942 109757818
Kounis syndrome 13.11 9.93 14 797525 5911 109785849
Cyst rupture 13.06 9.93 23 797516 852 109790908
Metabolic disorder 12.99 9.93 36 797503 10474 109781286
Renal tubular disorder 12.91 9.93 21 797518 7408 109784352
Secondary adrenocortical insufficiency 12.89 9.93 8 797531 4426 109787334
Iritis 12.89 9.93 67 797472 4585 109787175
Injection site rash 12.88 9.93 239 797300 23180 109768580
Areflexia 12.86 9.93 18 797521 6751 109785009
Vaginal discharge 12.85 9.93 76 797463 17832 109773928
Urinary incontinence 12.82 9.93 260 797279 48327 109743433
Peritoneal dialysis complication 12.82 9.93 44 797495 2502 109789258
Dermatitis bullous 12.79 9.93 74 797465 17455 109774305
Fungaemia 12.79 9.93 15 797524 6071 109785689
Complication of device insertion 12.71 9.93 28 797511 8810 109782950
Hypopituitarism 12.66 9.93 8 797531 4382 109787378
Vein disorder 12.63 9.93 83 797456 6187 109785573
Hypertonia 12.61 9.93 26 797513 8380 109783380
Pneumonia fungal 12.61 9.93 59 797480 14695 109777065
Enterobacter infection 12.56 9.93 14 797525 5797 109785963
Spinal cord compression 12.52 9.93 22 797517 7530 109784230
Leukoencephalopathy 12.52 9.93 30 797509 9165 109782595
Viraemia 12.49 9.93 7 797532 4095 109787665
Tubulointerstitial nephritis 12.45 9.93 297 797242 53987 109737773
Injection site extravasation 12.43 9.93 120 797419 10049 109781711
Wrong patient received product 12.43 9.93 18 797521 6656 109785104
Breast cancer female 12.43 9.93 47 797492 12421 109779339
Liver abscess 12.42 9.93 23 797516 7716 109784044
Epstein-Barr virus infection reactivation 12.40 9.93 7 797532 4077 109787683
Transient aphasia 12.39 9.93 20 797519 689 109791071
Cardiac dysfunction 12.38 9.93 16 797523 6207 109785553
Joint lock 12.35 9.93 55 797484 3533 109788227
Defaecation disorder 12.34 9.93 22 797517 823 109790937
Mitochondrial toxicity 12.34 9.93 4 797535 3241 109788519
Embolism 12.30 9.93 68 797471 16221 109775539
Human anti-human antibody test 12.29 9.93 15 797524 396 109791364
Oligoarthritis 12.27 9.93 21 797518 760 109791000
Fanconi syndrome 12.26 9.93 5 797534 3514 109788246
Product monitoring error 12.25 9.93 29 797510 8898 109782862
Frequent bowel movements 12.22 9.93 631 796908 70759 109721001
Lung opacity 12.22 9.93 43 797496 11609 109780151
Clonus 12.22 9.93 28 797511 8688 109783072
Pneumonitis 12.21 9.93 440 797099 76091 109715669
Pneumomediastinum 12.18 9.93 11 797528 5025 109786735
Crying 12.15 9.93 122 797417 25506 109766254
Sneezing 12.14 9.93 160 797379 31824 109759936
Vascular purpura 12.13 9.93 6 797533 3765 109787995
Tender joint count increased 12.08 9.93 15 797524 403 109791357
Ataxia 12.03 9.93 149 797390 29959 109761801
Pupillary reflex impaired 12.02 9.93 7 797532 4008 109787752
Impaired gastric emptying 12.00 9.93 52 797487 13223 109778537
Parvovirus B19 infection 11.97 9.93 3 797536 2878 109788882
Immunisation 11.97 9.93 4 797535 3179 109788581
Product dose omission in error 11.96 9.93 110 797429 23402 109768358
Nystagmus 11.96 9.93 43 797496 11534 109780226
Anger 11.94 9.93 84 797455 18923 109772837
Skin weeping 11.93 9.93 6 797533 3729 109788031
Burns second degree 11.91 9.93 96 797443 7637 109784123
Brain abscess 11.91 9.93 19 797520 6755 109785005
Corneal oedema 11.91 9.93 4 797535 3169 109788591
C-reactive protein decreased 11.89 9.93 47 797492 2862 109788898
Threatened labour 11.89 9.93 19 797520 649 109791111
Pain of skin 11.87 9.93 90 797449 19939 109771821
Respiratory tract infection 11.86 9.93 631 796908 70986 109720774
Airway remodelling 11.84 9.93 23 797516 919 109790841
Dermatitis exfoliative 11.82 9.93 42 797497 11305 109780455
Device breakage 11.81 9.93 55 797484 13714 109778046
Dactylitis 11.79 9.93 60 797479 4073 109787687
Hypothalamo-pituitary disorder 11.76 9.93 3 797536 2843 109788917
Quadriparesis 11.72 9.93 10 797529 4697 109787063
Drug abuser 11.72 9.93 13 797526 5396 109786364
Cogwheel rigidity 11.72 9.93 6 797533 3692 109788068
Medication error 11.70 9.93 897 796642 104469 109687291
Arteriosclerosis 11.70 9.93 118 797421 24649 109767111
Prerenal failure 11.70 9.93 9 797530 4450 109787310
Dizziness 11.69 9.93 4697 792842 693496 109098264
Schizoaffective disorder 11.69 9.93 4 797535 3132 109788628
Pancreatitis 11.68 9.93 553 796986 92980 109698780
Cold sweat 11.68 9.93 102 797437 21929 109769831
Cardiac tamponade 11.68 9.93 42 797497 11265 109780495
Bone fissure 11.67 9.93 18 797521 596 109791164
Blood potassium increased 11.66 9.93 169 797370 33080 109758680
Alcohol abuse 11.65 9.93 11 797528 4918 109786842
Autoimmune hepatitis 11.62 9.93 61 797478 14743 109777017
Appendicolith 11.61 9.93 58 797481 14197 109777563
Increased appetite 11.60 9.93 62 797477 14915 109776845
Rash morbilliform 11.59 9.93 25 797514 7926 109783834
Post procedural haemorrhage 11.58 9.93 65 797474 15447 109776313
Aspiration 11.49 9.93 153 797386 30380 109761380
Liver transplant rejection 11.49 9.93 7 797532 3911 109787849
Cystoid macular oedema 11.47 9.93 3 797536 2797 109788963
Carcinoid tumour of the small bowel 11.47 9.93 15 797524 425 109791335
Erythema of eyelid 11.47 9.93 7 797532 3908 109787852
Choking 11.45 9.93 63 797476 15047 109776713
Breast abscess 11.45 9.93 33 797506 1708 109790052
Oesophageal fibrosis 11.43 9.93 10 797529 176 109791584
Rhinovirus infection 11.39 9.93 45 797494 11744 109780016
Joint warmth 11.39 9.93 37 797502 2045 109789715
Arteriospasm coronary 11.38 9.93 31 797508 9069 109782691
Subileus 11.37 9.93 18 797521 6419 109785341
Labyrinthitis 11.35 9.93 48 797491 3014 109788746
Musculoskeletal disorder 11.34 9.93 228 797311 22436 109769324
Pancreatic carcinoma 11.28 9.93 62 797477 14810 109776950
Hypochloraemia 11.27 9.93 6 797533 3612 109788148
Blood phosphorus decreased 11.26 9.93 24 797515 7641 109784119
Mycobacterium chelonae infection 11.24 9.93 4 797535 3056 109788704
Inadequate analgesia 11.23 9.93 12 797527 5065 109786695
Brain herniation 11.23 9.93 30 797509 8833 109782927
Anaesthetic complication 11.21 9.93 6 797533 3600 109788160
Neutrophil count increased 11.18 9.93 179 797360 34473 109757287
Tumour marker increased 11.15 9.93 12 797527 5048 109786712
Lung transplant 11.14 9.93 13 797526 5273 109786487
Angina unstable 11.13 9.93 71 797468 16361 109775399
Hypoproteinaemia 11.10 9.93 16 797523 5929 109785831
Haemorrhagic transformation stroke 11.10 9.93 4 797535 3033 109788727
Staphylococcal sepsis 11.03 9.93 77 797462 17377 109774383
Oculogyric crisis 11.02 9.93 7 797532 3825 109787935
Disorganised speech 11.02 9.93 5 797534 3298 109788462
Catatonia 11.00 9.93 43 797496 11257 109780503
Cancer pain 10.98 9.93 20 797519 6752 109785008
Osteoporotic fracture 10.96 9.93 71 797468 5266 109786494
Hypovolaemic shock 10.94 9.93 61 797478 14522 109777238
Device issue 10.94 9.93 179 797360 34356 109757404
Myofascial pain syndrome 10.87 9.93 42 797497 2531 109789229
Fibroadenoma of breast 10.86 9.93 19 797520 700 109791060
Feeding disorder 10.84 9.93 100 797439 21262 109770498
Clear cell renal cell carcinoma 10.84 9.93 44 797495 2712 109789048
Apraxia 10.84 9.93 6 797533 3534 109788226
Terminal state 10.83 9.93 15 797524 5652 109786108
Eye movement disorder 10.82 9.93 35 797504 9693 109782067
Apnoea 10.82 9.93 56 797483 13583 109778177
Abortion threatened 10.77 9.93 15 797524 452 109791308
Tooth disorder 10.77 9.93 284 797255 29225 109762535
Unevaluable event 10.74 9.93 335 797204 58892 109732868
CD4 lymphocytes decreased 10.73 9.93 4 797535 2970 109788790
Uveitis 10.73 9.93 218 797321 21492 109770268
Persecutory delusion 10.73 9.93 18 797521 6273 109785487
Renal disorder 10.73 9.93 273 797266 49206 109742554
Skin graft failure 10.70 9.93 11 797528 239 109791521
Epidermal necrosis 10.68 9.93 47 797492 3003 109788757
Hereditary angioedema 10.68 9.93 22 797517 7092 109784668
Candida sepsis 10.65 9.93 4 797535 2957 109788803
Immune-mediated myocarditis 10.61 9.93 6 797533 3492 109788268
Tonic clonic movements 10.60 9.93 4 797535 2948 109788812
Cardiopulmonary failure 10.59 9.93 26 797513 7877 109783883
Pallor 10.58 9.93 318 797221 56149 109735611
Hospitalisation 10.55 9.93 884 796655 141609 109650151
Nasal obstruction 10.53 9.93 50 797489 3300 109788460
Malnutrition 10.52 9.93 136 797403 27143 109764617
Oral candidiasis 10.52 9.93 244 797295 44516 109747244
Pharyngitis streptococcal 10.51 9.93 144 797395 13133 109778627
Resuscitation 10.49 9.93 4 797535 2929 109788831
Post procedural haematoma 10.49 9.93 3 797536 2636 109789124
Cerebral haematoma 10.47 9.93 35 797504 9597 109782163
Exercise tolerance decreased 10.47 9.93 48 797491 12019 109779741
Muscle spasticity 10.46 9.93 189 797350 35726 109756034
Infusion site pain 10.45 9.93 78 797461 17341 109774419
Thirst 10.43 9.93 103 797436 21604 109770156
Pleuritic pain 10.42 9.93 169 797370 15971 109775789
Twin pregnancy 10.39 9.93 22 797517 936 109790824
Facial paralysis 10.38 9.93 118 797421 24096 109767664
Aphthous ulcer 10.37 9.93 212 797327 20924 109770836
Escherichia bacteraemia 10.34 9.93 38 797501 10126 109781634
Lip and/or oral cavity cancer 10.31 9.93 25 797514 1165 109790595
Hypokinesia 10.31 9.93 104 797435 21722 109770038
Skin necrosis 10.30 9.93 215 797324 21297 109770463
Oxygen saturation decreased 10.29 9.93 1288 796251 155694 109636066
Alcohol interaction 10.29 9.93 7 797532 3687 109788073
Tuberculin test positive 10.29 9.93 53 797486 3615 109788145
Paronychia 10.27 9.93 43 797496 11038 109780722
Trismus 10.24 9.93 20 797519 6576 109785184
Ischaemic cardiomyopathy 10.24 9.93 27 797512 7984 109783776
Drug specific antibody 10.23 9.93 44 797495 2784 109788976
Knee operation 10.19 9.93 86 797453 6936 109784824
Swollen joint count decreased 10.17 9.93 13 797526 360 109791400
Injection site haemorrhage 10.15 9.93 311 797228 32717 109759043
Brain death 10.14 9.93 20 797519 6553 109785207
Vacuum extractor delivery 10.14 9.93 8 797531 121 109791639
Mesothelioma 10.14 9.93 13 797526 361 109791399
Normochromic normocytic anaemia 10.14 9.93 54 797485 13003 109778757
Atrioventricular block second degree 10.13 9.93 28 797511 8153 109783607
Vertebral osteophyte 10.13 9.93 16 797523 541 109791219
Hemianopia 10.11 9.93 4 797535 2864 109788896
Gastric ulcer haemorrhage 10.09 9.93 38 797501 10056 109781704
Supraventricular tachycardia 10.08 9.93 120 797419 24302 109767458
Hepatic cytolysis 10.08 9.93 311 797228 54742 109737018
Coronary artery stenosis 10.08 9.93 58 797481 13700 109778060
Hyporesponsive to stimuli 10.07 9.93 4 797535 2856 109788904
Disinhibition 10.06 9.93 5 797534 3129 109788631
Loss of libido 10.05 9.93 5 797534 3128 109788632
Hepatitis E antibody positive 10.03 9.93 11 797528 258 109791502
Lip blister 10.00 9.93 49 797490 3276 109788484
Abortion missed 9.98 9.93 29 797510 1508 109790252
Hyperreflexia 9.95 9.93 35 797504 9450 109782310
Dermatitis 9.94 9.93 141 797398 27696 109764064
Joint ankylosis 9.93 9.93 40 797499 2457 109789303

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA04 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
ATC S01XA26 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
MeSH PA D003879 Dermatologic Agents
MeSH PA D011838 Radiation-Sensitizing Agents
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
MeSH PA D017319 Photosensitizing Agents
MeSH PA D018977 Micronutrients
CHEBI has role CHEBI:22586 antioxidant
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:47868 photosensitizing agent
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:76924 plant metabolite
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite
CHEBI has role CHEBI:77182 food colouring
CHEBI has role CHEBI:78675 fundamental metabolite
CHEBI has role CHEBI:84087 human urinary metabolite
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

A11HA Other plain vitamin preparations 10 drugs
biotincalcium pantothenatedexpanthenolinositolnicotinamidepantethinepyridoxal phosphatepyridoxinetocofersolanVitamin E
S01XA Other ophthalmologicals 24 drugs
acetylcysteinealteplasealumascorbic acidavacincaptad pegolcenegerminciclosporindexpanthenoldiquafosolethylmorphineguaiazulenheparin show all 24 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vitamin deficiency indication 85670002
Mineral deficiency indication 111379007
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Glutaric aciduria, type 2 off-label use 22886006 DOID:0060358
Glutaric aciduria, type 1 off-label use 76175005
Migraine Prevention off-label use
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Obstruction of bile duct contraindication 30144000
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Agoraphobia contraindication 70691001 DOID:593
Gastrointestinal hemorrhage contraindication 74474003
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Seizure disorder contraindication 128613002
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Panic disorder contraindication 371631005 DOID:594
Cardiovascular event risk contraindication 395112001
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Smokes tobacco daily contraindication 449868002
Acute Thromboembolic Stroke contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.13 acidic
pKa2 11.89 acidic
pKa3 13.48 acidic
pKa4 2.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
80MG/VIAL;0.02MG/VIAL;400 IU/VIAL;0.001MG/VIAL;5MG/VIAL;0.14MG/VIAL;17MG/VIAL;1MG/VIAL;1.4MG/VIAL;1.2MG/VIAL;7 IU/VIAL;2,300 IU/VIAL;0.2MG/VIAL MULTIPLE VITAMINS INJECTION PEDIATRIC APOTEX A210671 April 21, 2026 RX INJECTABLE INTRAVENOUS Dec. 21, 2026 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Flavin reductase (NADPH) Enzyme WOMBAT-PK
Riboflavin kinase Kinase WOMBAT-PK
Riboflavin-binding protein Secreted Kd 8.30 CHEMBL

External reference:

IDSource
4017778 VUID
N0000146139 NUI
D00050 KEGG_DRUG
4017633 VANDF
4017778 VANDF
4021901 VANDF
CHEBI:17015 CHEBI
RBF PDB_CHEM_ID
CHEMBL1534 ChEMBL_ID
6578 IUPHAR_LIGAND_ID
DB00140 DRUGBANK_ID
9346 RXNORM
391310 MMSL
5060 MMSL
5062 MMSL
5422 MMSL
5683 MMSL
d00409 MMSL
001059 NDDF
13235001 SNOMEDCT_US
329260009 SNOMEDCT_US
C0035527 UMLSCUI
D012256 MESH_DESCRIPTOR_UI
419 INN_ID
493570 PUBCHEM_CID
TLM2976OFR UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 3 mg ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 3.40 mg ORAL unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 3.40 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 3.40 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 3.40 mg ORAL Unapproved drug other 11 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 1.80 mg ORAL unapproved drug other 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 1.80 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OBCaplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1.80 mg ORAL unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
VitafolUltra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 1.80 mg ORAL unapproved drug other 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite OneCaplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 5 mg ORAL unapproved drug other 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 1.80 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 1.80 mg ORAL unapproved drug other 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 3.40 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 1.60 mg ORAL UNAPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 3 mg ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 3 mg ORAL UNAPPROVED DRUG OTHER 7 sections
JBA Collagen-Electrolyte Mocktail HUMAN OTC DRUG LABEL 12 13411-848 POWDER 1.60 mg ORAL unapproved drug other 6 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 3 mg ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 3 mg ORAL unapproved drug other 16 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 6 mg ORAL unapproved drug other 18 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 0.60 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 1 mg ORAL UNAPPROVED DRUG OTHER 11 sections