pyridoxal phosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3506 54-47-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pyridoxal 5-phosphate
  • codecarboxylase
  • coenzyme B6
  • phosphopyridoxal
  • phosphopyridoxal coenzyme
  • pyridoxal 5-monophosphoric acid ester
  • pyridoxal monophosphate
  • pyridoxaldehyde phosphate
  • pyridoxyl phosphate
  • Vitamin B6 phosphate
  • Vitamin B6 (Active form)
  • pyridoxal phosphate
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
  • Molecular weight: 247.14
  • Formula: C8H10NO6P
  • CLOGP: -0.57
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 116.95
  • ALOGS: -1.64
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT1,FLT3,GRK2,GRK3,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 66
kinase-selectivity-class AURKA,AURKB,AXL,BMX,BRAF,CDK1,CDK4,CDK9,DDR1,EPHB4,ERBB2,GRK2,IRAK1,IRAK3,MAP2K6,MAP3K21,MAPK7,PIK3CD,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70 24
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA06 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:75772 <em>Saccharomyces cerevisiae </em> metabolite
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite
CHEBI has role CHEBI:77746 human metabolite

Related Drugs by ATC class:

A11HA Other plain vitamin preparations 10 drugs
biotincalcium pantothenatedexpanthenolinositolnicotinamidepantethinepyridoxineriboflavintocofersolanVitamin E

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.56 acidic
pKa2 6.61 acidic
pKa3 8.45 acidic
pKa4 3.78 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
P2X purinoceptor 1 Ion channel IC50 5 CHEMBL
Low molecular weight phosphotyrosine protein phosphatase Enzyme Ki 4.89 CHEMBL

External reference:

IDSource
4024929 VUID
N0000023490 NUI
41468-25-1 SECONDARY_CAS_RN
4024929 VANDF
CHEBI:18405 CHEBI
PLP PDB_CHEM_ID
PXL PDB_CHEM_ID
CHEMBL3181870 ChEMBL_ID
CHEMBL82202 ChEMBL_ID
DB00114 DRUGBANK_ID
5V5IOJ8338 UNII
9002 RXNORM
227241 MMSL
30462 MMSL
327587 MMSL
003448 NDDF
019440 NDDF
259663004 SNOMEDCT_US
430926008 SNOMEDCT_US
770955002 SNOMEDCT_US
C0034266 UMLSCUI
D011732 MESH_DESCRIPTOR_UI
C0034263 UMLSCUI
DB00147 DRUGBANK_ID
1051 PUBCHEM_CID
66-72-8 SECONDARY_CAS_RN
5249 IUPHAR_LIGAND_ID
1050 PUBCHEM_CID
D011730 MESH_DESCRIPTOR_UI
CHEBI:17310 CHEBI
5V5IOJ8338 INXIGHT DRUGS

Pharmaceutical products:

None