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ethylmorphine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| opioid receptor antagonists/agonists, morphinan derivates | 3207 | 76-58-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A narcotic analgesic and antitussive. It is metabolized in the liver by ETHYLMORPHINE-N-DEMETHYLASE and used as an indicator of liver function.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 50 | mg | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 1.436 | High | 0.85 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 1.330 | High | 0.85 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 26.792 | 10^-6 cm/s | High | 0.85 |
| dh-clint | Dog hepatocyte intrinsic clearance | 34.514 | uL/min/10^6 cells | High | 0.85 |
| dppb | Dog plasma protein binding (% unbound) | 65.370 | % | High | 0.85 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 75.970 | % | High | 0.85 |
| herg | hERG pIC50 | 4.594 | pIC50 | High | 0.85 |
| hh-clint | Human hepatocyte intrinsic clearance | 3.041 | uL/min/10^6 cells | High | 0.85 |
| hlm-clint | Human liver microsomal intrinsic clearance | 8.433 | uL/min/mg protein | High | 0.85 |
| hppb | Human plasma protein binding (% unbound) | 64.640 | % | High | 0.85 |
| kinase-safety-class | ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,JAK3,MAP2K6,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1,ZAP70 | 40 | |||
| kinase-selectivity-class | EIF2AK3 | 1 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 1.400 | High | 0.85 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 46.345 | High | 0.85 | |
| mppb | Mouse plasma protein binding (% unbound) | 54.480 | High | 0.85 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 4.375 | High | 0.85 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 78.600 | % | High | 0.85 |
| rh-clint | Rat hepatocyte intrinsic clearance | 121.060 | uL/min/10^6 cells | High | 0.85 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 83.590 | % | High | 0.85 |
| rppb | Rat plasma protein binding (% unbound) | 53.450 | % | High | 0.85 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 970.510 | uM | High | 0.85 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R05DA01 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS Opium alkaloids and derivatives |
| ATC | S01XA06 | SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000701 | Analgesics, Opioid |
| MeSH PA | D000996 | Antitussive Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D009294 | Narcotics |
| MeSH PA | D018689 | Sensory System Agents |
| MeSH PA | D019141 | Respiratory System Agents |
Related Drugs by ATC class:
R05DA Opium alkaloids and derivatives 10 drugs
S01XA Other ophthalmologicals 24 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.38 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000167302 | NUI |
| D07929 | KEGG_DRUG |
| C0015109 | UMLSCUI |
| CHEBI:4902 | CHEBI |
| CHEMBL1712170 | ChEMBL_ID |
| DB01466 | DRUGBANK_ID |
| D005036 | MESH_DESCRIPTOR_UI |
| 5359271 | PUBCHEM_CID |
| RWO67D87EU | UNII |
| 4166 | RXNORM |
| 003787 | NDDF |
| 74905005 | SNOMEDCT_US |
Pharmaceutical products:
None