pantethine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	3417	16816-67-4

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

pantethine
lipodel
pantetina
panthecin
pantomin
pantosin

Molecular weight: 554.72
Formula: C22H42N4O8S2
CLOGP: -1.44
LIPINSKI: 3
HAC: 12
HDO: 8
TPSA: 197.32
ALOGS: -3.67
ROTB: 19

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AKT2,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70	57
kinase-selectivity-class	ACVRL1,AXL,BMX,BRAF,CDK16,CDK6,CDK9,CHUK,DYRK1A,GRK2,IRAK3,MAP2K6,PDK1,PDK2,PIK3CD,TEK	16
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Platelet count decreased	54.57	39.95	26	800	136943	90490678

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia	40.46	31.97	43	714	422106	42198472

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Platelet count decreased	70.01	31.56	45	1800	230398	110357056
Hepatic function abnormal	55.82	31.56	28	1817	89267	110498187
Interstitial lung disease	46.71	31.56	29	1816	139305	110448149
Ileus	46.65	31.56	18	1827	30711	110556743
Pneumonia	42.79	31.56	62	1783	876652	109710802
Neutrophil count decreased	42.63	31.56	26	1819	120915	110466539
Pneumonia aspiration	38.01	31.56	21	1824	81212	110506242
Decreased appetite	36.23	31.56	42	1803	475804	110111650
Pyrexia	33.27	31.56	56	1789	898209	109689245
Salivary hypersecretion	32.98	31.56	12	1833	17409	110570045

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11HA32	ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations
CHEBI has role	CHEBI:23354	coenzyme
CHEBI has role	CHEBI:50733	nutraceutical

Related Drugs by ATC class:

A11HA Other plain vitamin preparations 10 drugs

biotin calcium pantothenate dexpanthenol inositol nicotinamide pyridoxal phosphate pyridoxine riboflavin tocofersolan Vitamin E

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.1	acidic
pKa2	12.7	acidic
pKa3	13.1	acidic
pKa4	13.7	acidic
pKa5	13.9	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D01234	KEGG_DRUG
C0070034	UMLSCUI
CHEMBL2104786	ChEMBL_ID
DB11190	DRUGBANK_ID
C005425	MESH_SUPPLEMENTAL_RECORD_UI
7K81IL792L	UNII
452306	PUBCHEM_CID
32863	RXNORM
006957	NDDF
CHEBI:31959	CHEBI

Pharmaceutical products:

None