inositol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1444 87-89-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • inositol
  • myo-Inositol
  • cyclohexanehexol
  • cyclohexitol
  • inosital
  • inositene
  • inositina
  • mesoinositol
  • myoinosite
  • myoinositol
An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
  • Molecular weight: 180.16
  • Formula: C6H12O6
  • CLOGP: -0.12
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 6
  • TPSA: 121.38
  • ALOGS: 0.43
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA07 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Hypoalphalipoproteinemia indication 190785000
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Pellagra indication 418186002 DOID:8457
Niacin deficiency indication 418279001
Slow Progression of Coronary Artery Disease indication
Myocardial Reinfarction Prevention indication
Hyperlipidemia off-label use 55822004 DOID:1168
Hypophosphatemia contraindication 4996001
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Acute cerebrovascular insufficiency contraindication 29322000
Low blood pressure contraindication 45007003
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Gout contraindication 90560007 DOID:13189
Liver function tests abnormal contraindication 166603001
Cerebrovascular accident contraindication 230690007
Arterial hemorrhage contraindication 234003006
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Acute coronary syndrome contraindication 394659003
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Cerebral infarction contraindication 432504007 DOID:3526

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.21 acidic
pKa2 13.31 acidic
pKa3 13.71 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D007294 MESH_DESCRIPTOR_UI
4017688 VUID
N0000146062 NUI
C0021547 UMLSCUI
D08079 KEGG_DRUG
4L6452S749 UNII
10437 INN_ID
108960004 SNOMEDCT_US
5751 MMSL
5833 RXNORM
72164009 SNOMEDCT_US
4879 MMSL
d00496 MMSL
4017688 VANDF
002057 NDDF
892 PUBCHEM_CID
CHEBI:17268 CHEBI
INS PDB_CHEM_ID
CHEMBL1222251 ChEMBL_ID
DB13178 DRUGBANK_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lipovite HUMAN PRESCRIPTION DRUG LABEL 11 70104-128 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
MIC B12 HUMAN PRESCRIPTION DRUG LABEL 3 70104-806 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
NEONATAL PLUS VITAMIN HUMAN PRESCRIPTION DRUG LABEL 13 70898-115 TABLET 5 mg ORAL unapproved drug other 9 sections
Viatrexx-Liver HUMAN PRESCRIPTION DRUG LABEL 9 73069-300 INJECTION 31 [kp_C] INTRAVENOUS unapproved drug other 11 sections