Vitamin E 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3613 1406-18-4

Description:

MoleculeDescription

Synonyms:

  • tocopherol (vit E)
  • Vitamin E
  • Tocofer 400
A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA03 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
MeSH PA D000975 Antioxidants
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:22586 antioxidant
CHEBI has role CHEBI:24020 fat-soluble vitamin (role)
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:50247 antidote
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:233423 antifibrotic agent

Related Drugs by ATC class:

A11HA Other plain vitamin preparations 10 drugs
biotincalcium pantothenatedexpanthenolinositolnicotinamidepantethinepyridoxal phosphatepyridoxineriboflavintocofersolan

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vitamin E deficiency indication 54137008




🐶 Veterinary Drug Use

SpeciesUseRelation
Cattle Prevention and treatment of selenium-tocopherol deficiency syndrome Indication
Sheep Prevention and treatment of selenium-tocopherol deficiency syndrome Indication
Swine Diseases associated with Selenium-Tocopherol deficiency Indication

🐶 Veterinary products

ProductApplicantIngredients
BO-SE Intervet Inc. 2
Seletoc Minicaps and Caps Intervet Inc. 2
Mu-Se Intervet Inc. 2
E-SE Intervet Inc. 2
Seletoc Injection Intervet Inc. 2
Velenium Zoetis Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glutathione S-transferase P Enzyme IC50 6.30 CHEMBL
Alpha-tocopherol transfer protein Transporter Kd 5.62 CHEMBL

External reference:

IDSource
4017656 VUID
N0000146035 NUI
D02331 KEGG_DRUG
4017656 VANDF
4021718 VANDF
C0042874 UMLSCUI
CHEBI:18145 CHEBI
VIT PDB_CHEM_ID
CHEMBL3989727 ChEMBL_ID
D014810 MESH_DESCRIPTOR_UI
DB00163 DRUGBANK_ID
14985 PUBCHEM_CID
11256 RXNORM
37013 MMSL
5201 MMSL
5689 MMSL
d00405 MMSL
37237003 SNOMEDCT_US
63822004 SNOMEDCT_US

Pharmaceutical products:

None