All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

alteplase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
enzymes	5141	105857-23-6

Description:

Molecule

Description

Synonyms: alteplase activase alteplase (genetical recombination)

A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases. Is currently clinical tested as treatment for COVID-19 patients. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
0.10	g	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
June 18, 1996	FDA	GENENTECH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gingival bleeding	1729.48	27.12	401	11875	14502	90601669
Haemorrhagic transformation stroke	1103.78	27.12	185	12091	1114	90615057
No adverse event	1089.91	27.12	391	11885	67591	90548580
Cerebral haemorrhage	1070.88	27.12	327	11949	34195	90581976
Angioedema	897.82	27.12	335	11941	64541	90551630
Haemorrhage intracranial	691.91	27.12	194	12082	14968	90601203
Off label use	388.07	27.12	597	11679	1101655	89514516
Haemorrhage	323.99	27.12	167	12109	69202	90546969
Death	272.25	27.12	321	11955	456230	90159941
Neurological decompensation	240.77	27.12	62	12214	3439	90612732
Tongue haemorrhage	208.16	27.12	39	12237	472	90615699
Aplastic anaemia	188.34	27.12	70	12206	13199	90602972
Swollen tongue	173.19	27.12	96	12180	45860	90570311
Subarachnoid haemorrhage	161.29	27.12	68	12208	17836	90598335
Cerebral haematoma	155.76	27.12	46	12230	4243	90611928
Cerebral infarction	153.46	27.12	74	12202	26522	90589649
Tongue oedema	149.01	27.12	47	12229	5407	90610764
Brain herniation	130.75	27.12	40	12236	4160	90612011
Mouth haemorrhage	124.86	27.12	46	12230	8455	90607716
NIH stroke scale score increased	118.61	27.12	15	12261	0	90616171
Blood fibrinogen decreased	117.07	27.12	28	12248	1142	90615029
Intraventricular haemorrhage	109.78	27.12	31	12245	2438	90613733
Brain oedema	93.15	27.12	46	12230	17339	90598832
Thrombolysis	90.73	27.12	16	12260	134	90616037
Haemorrhagic cerebral infarction	83.48	27.12	19	12257	622	90615549
NIH stroke scale abnormal	82.19	27.12	11	12265	6	90616165
Hemiparesis	79.41	27.12	51	12225	31768	90584403
Haematoma	79.18	27.12	55	12221	38993	90577178
Brain stem haemorrhage	78.57	27.12	19	12257	812	90615359
Stroke in evolution	76.68	27.12	13	12263	84	90616087
Intracranial mass	75.23	27.12	20	12256	1255	90614916
Respiratory failure	71.31	27.12	84	12192	118334	90497837
Lip swelling	70.47	27.12	51	12225	38559	90577612
Cerebral mass effect	69.02	27.12	18	12258	1048	90615123
Ecchymosis	67.19	27.12	33	12243	12290	90603881
Haemorrhagic infarction	60.88	27.12	13	12263	315	90615856
Subcutaneous haematoma	58.89	27.12	18	12258	1865	90614306
Aphasia	57.21	27.12	47	12229	42765	90573406
Hypotension	57.18	27.12	132	12144	325265	90290906
Cerebral hyperperfusion syndrome	54.15	27.12	8	12268	17	90616154
Cardiogenic shock	53.23	27.12	36	12240	24432	90591739
Coma	51.31	27.12	56	12220	72576	90543595
Haemothorax	50.48	27.12	17	12259	2401	90613770
Reperfusion arrhythmia	47.37	27.12	10	12266	229	90615942
Abdominal discomfort	47.00	27.12	5	12271	477323	90138848
Cardiac arrest	46.61	27.12	64	12212	104871	90511300
Arthralgia	46.20	27.12	24	12252	778498	89837673
Ventricular extrasystoles	45.32	27.12	26	12250	13224	90602947
Ischaemic stroke	44.41	27.12	31	12245	22135	90594036
Diarrhoea	42.43	27.12	39	12237	939151	89677020
Macular hole	42.13	27.12	12	12264	973	90615198
Intra-abdominal haemorrhage	41.29	27.12	15	12261	2647	90613524
Epistaxis	40.98	27.12	54	12222	85071	90531100
Alopecia	40.12	27.12	9	12267	495062	90121109
Extravasation	39.72	27.12	15	12261	2949	90613222
Nasopharyngitis	38.24	27.12	5	12271	407099	90209072
Product quality issue	37.69	27.12	50	12226	79275	90536896
Haemorrhagic stroke	37.22	27.12	18	12258	6478	90609693
Drug interaction	36.82	27.12	101	12175	276352	90339819
Dysarthria	36.73	27.12	41	12235	54441	90561730
Cardiac tamponade	36.54	27.12	17	12259	5615	90610556
Embolism	36.21	27.12	20	12256	9461	90606710
Cerebellar haemorrhage	36.01	27.12	12	12264	1641	90614530
Reocclusion	35.60	27.12	5	12271	6	90616165
Procedural haemorrhage	35.42	27.12	14	12262	3110	90613061
Hydrocephalus	35.26	27.12	17	12259	6077	90610094
Shock	33.12	27.12	29	12247	28749	90587422
Stridor	32.76	27.12	15	12261	4778	90611393
Glossodynia	32.63	27.12	3	12273	321776	90294395
Hepatic enzyme increased	32.54	27.12	5	12271	360731	90255440
Fatigue	32.04	27.12	68	12208	1153955	89462216
Reperfusion injury	31.62	27.12	6	12270	78	90616093
Basal ganglia haemorrhage	31.33	27.12	9	12267	752	90615419
Heparin-induced thrombocytopenia	31.29	27.12	15	12261	5297	90610874
Haemorrhage subcutaneous	30.91	27.12	13	12263	3383	90612788
Catheter site haemorrhage	29.94	27.12	13	12263	3655	90612516
Brain death	28.79	27.12	13	12263	4008	90612163
Retroperitoneal haemorrhage	28.73	27.12	12	12264	3068	90613103
Ventricular tachycardia	28.64	27.12	25	12251	24683	90591488
Weight increased	27.67	27.12	11	12265	417916	90198255

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gingival bleeding	2513.21	20.64	590	15187	7895	42597663
No adverse event	1782.77	20.64	632	15145	38389	42567169
Haemorrhagic transformation stroke	1343.48	20.64	268	15509	1523	42604035
Cerebral haemorrhage	901.60	20.64	386	15391	38580	42566978
Haemorrhage intracranial	716.75	20.64	261	15516	16931	42588627
Angioedema	550.05	20.64	282	15495	42195	42563363
Off label use	541.89	20.64	891	14886	637444	41968114
Neurological decompensation	307.16	20.64	95	15682	3694	42601864
Haemorrhage	254.53	20.64	197	15580	60366	42545192
Tongue haemorrhage	199.62	20.64	48	15729	703	42604855
Ventricular extrasystoles	196.70	20.64	97	15680	13293	42592265
Haemorrhagic infarction	183.96	20.64	42	15735	484	42605074
Mouth haemorrhage	171.02	20.64	70	15707	6191	42599367
NIH stroke scale score increased	139.84	20.64	22	15755	16	42605542
Cerebral infarction	132.09	20.64	102	15675	31067	42574491
Intraventricular haemorrhage	125.42	20.64	49	15728	3835	42601723
Tongue oedema	122.06	20.64	46	15731	3264	42602294
Aplastic anaemia	120.10	20.64	68	15709	12316	42593242
Cerebral haematoma	117.62	20.64	52	15725	5558	42600000
Brain oedema	117.56	20.64	74	15703	16253	42589305
Brain stem haemorrhage	114.97	20.64	33	15744	986	42604572
Ventricular tachycardia	111.30	20.64	91	15686	30069	42575489
Subarachnoid haemorrhage	102.71	20.64	65	15712	14407	42591151
Haematoma	102.24	20.64	84	15693	27939	42577619
Death	101.39	20.64	392	15385	470793	42134765
Hemiparesis	98.91	20.64	68	15709	17308	42588250
Brain herniation	98.84	20.64	44	15733	4779	42600779
Blood fibrinogen decreased	92.26	20.64	31	15746	1572	42603986
Swollen tongue	88.88	20.64	69	15708	21162	42584396
Stroke in evolution	84.90	20.64	15	15762	37	42605521
Chest pain	82.24	20.64	168	15609	139362	42466196
Haemorrhagic cerebral infarction	79.24	20.64	24	15753	867	42604691
Reperfusion arrhythmia	74.67	20.64	15	15762	88	42605470
Haemorrhagic stroke	72.72	20.64	41	15736	7361	42598197
Ischaemic stroke	69.51	20.64	61	15716	22172	42583386
Thrombolysis	67.94	20.64	14	15763	95	42605463
Cerebral artery occlusion	63.60	20.64	20	15757	820	42604738
Aphasia	63.40	20.64	60	15717	24023	42581535
Cerebral mass effect	62.04	20.64	22	15755	1312	42604246
Diarrhoea	60.94	20.64	49	15728	460800	42144758
Toxicity to various agents	60.55	20.64	7	15770	229129	42376429
Cerebral hyperperfusion syndrome	57.91	20.64	12	15765	84	42605474
Hemiplegia	57.42	20.64	36	15741	7843	42597715
Extrasystoles	57.37	20.64	29	15748	4180	42601378
Dysphoria	49.50	20.64	23	15754	2757	42602801
Coma	48.78	20.64	78	15699	53476	42552082
Fatigue	48.55	20.64	54	15723	435587	42169971
Basal ganglia haemorrhage	47.35	20.64	17	15760	1051	42604507
Electrocardiogram ST segment elevation	42.94	20.64	27	15750	5912	42599646
Fall	40.64	20.64	18	15759	234502	42371056
Bradycardia	40.11	20.64	94	15683	85390	42520168
Cardiac arrest	38.63	20.64	108	15669	109212	42496346
Product closure issue	38.35	20.64	6	15771	4	42605554
Hypotension	37.32	20.64	191	15586	257440	42348118
Coagulopathy	36.48	20.64	43	15734	22119	42583439
Intracranial pressure increased	35.69	20.64	22	15755	4652	42600906
Cardiac ventricular thrombosis	35.35	20.64	16	15761	1806	42603752
Reocclusion	34.19	20.64	6	15771	14	42605544
Extravasation blood	33.40	20.64	8	15769	115	42605443
Product quality issue	33.32	20.64	37	15740	17845	42587713
Epistaxis	33.01	20.64	75	15702	66751	42538807
Aortic dissection	32.86	20.64	18	15759	3054	42602504
Malaise	32.68	20.64	19	15758	212137	42393421
NIH stroke scale abnormal	32.16	20.64	5	15772	3	42605555
Haematuria	32.10	20.64	68	15709	57731	42547827
Paresis	30.56	20.64	16	15761	2480	42603078
Reperfusion injury	30.39	20.64	7	15770	84	42605474
Decreased appetite	30.17	20.64	17	15760	193120	42412438
Lip swelling	29.76	20.64	36	15741	19017	42586541
Weight decreased	28.80	20.64	21	15756	207927	42397631
Haemothorax	28.63	20.64	20	15757	5216	42600342
Central nervous system haemorrhage	28.18	20.64	7	15770	118	42605440
Catheter site haemorrhage	27.45	20.64	15	15762	2533	42603025
Haemorrhage subcutaneous	26.92	20.64	15	15762	2631	42602927
Neutropenia	26.51	20.64	21	15756	199410	42406148
Intentional product use issue	26.38	20.64	72	15705	71761	42533797
Ventricular fibrillation	26.22	20.64	43	15734	30080	42575478
Laryngeal oedema	25.95	20.64	17	15760	3991	42601567
Constipation	25.75	20.64	14	15763	162277	42443281
Embolism	25.31	20.64	23	15754	8740	42596818
Puncture site haemorrhage	25.12	20.64	8	15769	342	42605216
Rhythm idioventricular	25.05	20.64	8	15769	345	42605213
Product dose omission issue	24.96	20.64	13	15764	154352	42451206
Parotid gland haemorrhage	24.79	20.64	5	15772	30	42605528
Shock	24.58	20.64	41	15736	29080	42576478
Arthralgia	24.40	20.64	24	15753	205214	42400344
Bullous haemorrhagic dermatosis	24.39	20.64	6	15771	97	42605461
Myocardial rupture	24.29	20.64	7	15770	212	42605346
Thrombectomy	24.22	20.64	6	15771	100	42605458
Hydrocephalus	23.80	20.64	19	15758	6059	42599499
Product use in unapproved indication	23.80	20.64	20	15757	184436	42421122
Cerebral ischaemia	23.58	20.64	20	15757	6939	42598619
Anaemia	22.99	20.64	43	15734	280235	42325323
Extravasation	22.83	20.64	13	15764	2377	42603181
Dehydration	22.82	20.64	12	15765	141755	42463803
Cerebral reperfusion injury	22.60	20.64	4	15773	10	42605548
Hyponatraemia	22.51	20.64	5	15772	101457	42504101
Disease progression	21.92	20.64	13	15764	143643	42461915
Depression	21.85	20.64	7	15770	111356	42494202
Hyperhidrosis	21.48	20.64	78	15699	90434	42515124
Paralysis	21.41	20.64	19	15758	7001	42598557
Vitreous haemorrhage	21.15	20.64	13	15764	2734	42602824
Lip haemorrhage	20.81	20.64	9	15768	911	42604647
Weight increased	20.81	20.64	7	15770	107976	42497582
Factor I deficiency	20.71	20.64	3	15774	0	42605558
NIH stroke scale score decreased	20.71	20.64	3	15774	0	42605558
Hemianopia	20.70	20.64	9	15768	923	42604635

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gingival bleeding	4311.87	21.95	976	23756	18863	110545704
No adverse event	2876.89	21.95	936	23796	72903	110491664
Haemorrhagic transformation stroke	2270.76	21.95	418	24314	2619	110561948
Cerebral haemorrhage	1873.96	21.95	658	24074	64310	110500257
Angioedema	1260.35	21.95	554	24178	97946	110466621
Haemorrhage intracranial	1221.67	21.95	391	24341	28578	110535989
Off label use	963.54	21.95	1403	23329	1498782	109065785
Haemorrhage	467.16	21.95	293	24439	106399	110458168
Tongue haemorrhage	404.50	21.95	85	24647	1120	110563447
Cerebral haematoma	332.93	21.95	112	24620	9520	110555047
Cerebral infarction	304.02	21.95	172	24560	51666	110512901
Mouth haemorrhage	303.33	21.95	114	24618	13374	110551193
Aplastic anaemia	301.21	21.95	134	24598	24174	110540393
Neurological decompensation	281.94	21.95	91	24641	6792	110557775
Subarachnoid haemorrhage	257.63	21.95	128	24604	29574	110534993
NIH stroke scale score increased	255.55	21.95	37	24695	24	110564543
Tongue oedema	246.33	21.95	86	24646	8170	110556397
Brain herniation	240.36	21.95	86	24646	8777	110555790
Swollen tongue	227.49	21.95	151	24581	60211	110504356
Intraventricular haemorrhage	210.11	21.95	69	24663	5438	110559129
Brain oedema	209.22	21.95	113	24619	30985	110533582
Haemorrhagic cerebral infarction	200.77	21.95	50	24682	1445	110563122
Death	200.23	21.95	465	24267	698404	109866163
Brain stem haemorrhage	190.84	21.95	50	24682	1776	110562791
Blood fibrinogen decreased	189.81	21.95	54	24678	2621	110561946
Haematoma	168.25	21.95	124	24608	58352	110506215
Hemiparesis	163.39	21.95	109	24623	43794	110520773
Stroke in evolution	155.75	21.95	27	24705	112	110564455
Cerebral mass effect	154.53	21.95	45	24687	2374	110562193
Thrombolysis	148.17	21.95	29	24703	260	110564307
Haemorrhagic infarction	146.20	21.95	35	24697	854	110563713
Aphasia	117.92	21.95	101	24631	58896	110505671
NIH stroke scale abnormal	111.36	21.95	16	24716	9	110564558
Cerebral hyperperfusion syndrome	110.87	21.95	20	24712	109	110564458
Haemorrhagic stroke	100.87	21.95	53	24679	13736	110550831
Fatigue	98.55	21.95	77	24655	1215881	109348686
Ventricular extrasystoles	95.95	21.95	61	24671	22580	110541987
Diarrhoea	88.76	21.95	75	24657	1139430	109425137
Coma	88.42	21.95	120	24612	117749	110446818
Intracranial mass	87.39	21.95	29	24703	2359	110562208
Cardiac arrest	84.43	21.95	155	24577	196598	110367969
Lip swelling	81.97	21.95	77	24655	50590	110513977
Arthralgia	81.95	21.95	36	24696	779596	109784971
Joint swelling	79.29	21.95	5	24727	442840	110121727
Ischaemic stroke	79.12	21.95	69	24663	41194	110523373
Toxicity to various agents	78.89	21.95	8	24724	480547	110084020
Haemothorax	78.31	21.95	36	24696	6995	110557572
Epistaxis	77.69	21.95	119	24613	130253	110434314
Ventricular tachycardia	77.09	21.95	74	24658	49935	110514632
Cerebral artery occlusion	76.29	21.95	25	24707	1955	110562612
Nasopharyngitis	75.20	21.95	3	24729	394358	110170209
Respiratory failure	74.58	21.95	155	24577	215177	110349390
Hemiplegia	73.94	21.95	52	24680	22730	110541837
Basal ganglia haemorrhage	73.40	21.95	24	24708	1864	110562703
Ecchymosis	71.69	21.95	46	24686	17292	110547275
Coagulopathy	69.70	21.95	64	24668	40847	110523720
Subcutaneous haematoma	69.47	21.95	26	24706	3010	110561557
Drug intolerance	66.11	21.95	7	24725	406505	110158062
Dysphoria	65.66	21.95	31	24701	6397	110558170
Reperfusion arrhythmia	65.54	21.95	15	24717	299	110564268
Malaise	64.52	21.95	35	24697	671784	109892783
Pain	63.69	21.95	72	24660	954883	109609684
Aortic dissection	63.67	21.95	28	24704	4905	110559662
Hydrocephalus	62.32	21.95	35	24697	10340	110554227
Embolism	61.92	21.95	41	24691	16248	110548319
Haemorrhage subcutaneous	60.56	21.95	28	24704	5511	110559056
Reperfusion injury	59.79	21.95	13	24719	203	110564364
Alopecia	57.50	21.95	7	24725	364746	110199821
Hypotension	57.01	21.95	250	24482	523599	110040968
Abdominal discomfort	56.45	21.95	10	24722	393848	110170719
Fall	54.30	21.95	34	24698	603448	109961119
Weight increased	53.34	21.95	14	24718	419630	110144937
Product closure issue	52.76	21.95	8	24724	10	110564557
Intra-abdominal haemorrhage	52.23	21.95	25	24707	5317	110559250
Shock	51.93	21.95	62	24670	53526	110511041
Musculoskeletal stiffness	50.54	21.95	3	24729	279819	110284748
Product quality issue	49.51	21.95	73	24659	77226	110487341
Vitreous haemorrhage	49.41	21.95	23	24709	4597	110559970
Dysarthria	48.99	21.95	76	24656	84045	110480522
Intracranial pressure increased	48.70	21.95	30	24702	10505	110554062
Cardiogenic shock	48.58	21.95	62	24670	57276	110507291
Hepatic enzyme increased	48.56	21.95	7	24725	320885	110243682
Depression	47.84	21.95	7	24725	317328	110247239
Haematuria	46.96	21.95	74	24658	82931	110481636
Cerebellar haemorrhage	46.91	21.95	20	24712	3251	110561316
Cardiac tamponade	46.75	21.95	30	24702	11277	110553290
Hypofibrinogenaemia	45.01	21.95	18	24714	2489	110562078
Catheter site haemorrhage	44.14	21.95	23	24709	5857	110558710
Pericardial haemorrhage	43.79	21.95	22	24710	5195	110559372
Laryngeal oedema	42.99	21.95	27	24705	9780	110554787
Gastrointestinal disorder	42.49	21.95	3	24729	241949	110322618
Weight decreased	41.21	21.95	27	24705	468030	110096537
Insomnia	40.50	21.95	15	24717	360575	110203992
Myocardial rupture	40.35	21.95	10	24722	283	110564284
Haematemesis	39.56	21.95	57	24675	59051	110505516
Treatment delayed	39.44	21.95	11	24721	496	110564071
Heparin-induced thrombocytopenia	39.23	21.95	27	24705	11397	110553170
Brain death	39.01	21.95	22	24710	6551	110558016
Asthma	38.95	21.95	5	24727	250286	110314281
Mobility decreased	38.80	21.95	4	24728	237418	110327149
Lip oedema	38.63	21.95	23	24709	7577	110556990
Glossodynia	38.27	21.95	3	24729	222001	110342566
Thrombectomy	37.82	21.95	10	24722	368	110564199
Facial paralysis	37.63	21.95	36	24696	24178	110540389
Decreased appetite	37.30	21.95	31	24701	475815	110088752
Anaphylactic reaction	36.90	21.95	80	24652	114220	110450347
Abdominal pain upper	36.79	21.95	16	24716	349095	110215472
Extravasation	36.51	21.95	19	24713	4826	110559741
Product use in unapproved indication	36.50	21.95	28	24704	447349	110117218
Pulseless electrical activity	36.17	21.95	30	24702	16727	110547840
Embolic stroke	35.66	21.95	23	24709	8720	110555847
Cytokine release syndrome	34.78	21.95	59	24673	70247	110494320
Peripheral swelling	34.63	21.95	24	24708	404010	110160557
Procedural haemorrhage	34.49	21.95	19	24713	5408	110559159
Respiratory distress	34.34	21.95	58	24674	68816	110495751
Cerebral artery embolism	33.92	21.95	14	24718	2098	110562469
Sinusitis	33.89	21.95	12	24720	296676	110267891
Product dose omission issue	33.51	21.95	15	24717	321767	110242800
Sleep disorder	33.37	21.95	3	24729	198641	110365926
Cerebral reperfusion injury	33.06	21.95	6	24726	34	110564533
Compartment syndrome	32.97	21.95	19	24713	5891	110558676
Hemianopia	32.93	21.95	15	24717	2853	110561714
Stridor	32.80	21.95	20	24712	6875	110557692
Retroperitoneal haemorrhage	32.52	21.95	19	24713	6046	110558521
Inflammation	32.25	21.95	3	24729	193235	110371332
Macular hole	31.75	21.95	11	24721	1020	110563547
Cardiac ventricular thrombosis	31.60	21.95	15	24717	3132	110561435
Tongue haematoma	31.36	21.95	8	24724	255	110564312
Central nervous system haemorrhage	31.33	21.95	9	24723	452	110564115
Reocclusion	31.22	21.95	5	24727	11	110564556
Paresis	30.89	21.95	17	24715	4827	110559740
Drug hypersensitivity	30.44	21.95	34	24698	454056	110110511
Pericarditis	30.44	21.95	6	24726	219108	110345459
Impaired healing	30.44	21.95	4	24728	196713	110367854
Pain in extremity	29.98	21.95	39	24693	487079	110077488
Endotracheal intubation	29.69	21.95	18	24714	6126	110558441
Carotid artery occlusion	29.11	21.95	21	24711	9544	110555023
Myalgia	29.05	21.95	7	24725	222374	110342193
Bradycardia	28.53	21.95	88	24644	155429	110409138
Lip haemorrhage	28.08	21.95	11	24721	1441	110563126
Blood pressure decreased	27.85	21.95	72	24660	115019	110449548
Electrocardiogram ST segment elevation	27.63	21.95	20	24712	9140	110555427
Osteoarthritis	27.58	21.95	4	24728	182619	110381948
Asthenia	27.44	21.95	72	24660	688927	109875640
Therapeutic product effect incomplete	27.42	21.95	8	24724	223797	110340770
Completed suicide	27.34	21.95	10	24722	242371	110322196
Swelling	27.33	21.95	23	24709	351018	110213549
Infusion related reaction	27.27	21.95	27	24705	381135	110183432
Influenza	27.24	21.95	3	24729	169098	110395469
Parotid gland haemorrhage	27.17	21.95	5	24727	31	110564536
Cerebral ischaemia	26.81	21.95	22	24710	12082	110552485
Pharyngeal oedema	26.62	21.95	25	24707	16403	110548164
Peripheral artery occlusion	26.60	21.95	13	24719	2892	110561675
Extravasation blood	26.07	21.95	8	24724	505	110564062
Upper gastrointestinal haemorrhage	26.06	21.95	43	24689	50053	110514514
Constipation	25.99	21.95	25	24707	357761	110206806
Depressed level of consciousness	25.90	21.95	69	24663	112209	110452358
Discomfort	25.71	21.95	8	24724	214699	110349868
Rash	25.51	21.95	96	24636	820868	109743699
Migraine	25.37	21.95	4	24728	171648	110392919
Hypoxia	25.36	21.95	75	24657	129440	110435127
Lividity	24.70	21.95	8	24724	603	110563964
Retroperitoneal haematoma	24.69	21.95	16	24716	6115	110558452
Intracardiac thrombus	24.56	21.95	14	24718	4254	110560313
Muscle spasms	24.52	21.95	16	24716	278141	110286426
Therapeutic product effect decreased	24.49	21.95	12	24720	244304	110320263
Injury	24.32	21.95	5	24727	177260	110387307
Haemoperitoneum	24.03	21.95	15	24717	5373	110559194
Paralysis	23.87	21.95	23	24709	15577	110548990
Dizziness	23.44	21.95	79	24653	698114	109866453
Puncture site haemorrhage	23.28	21.95	8	24724	724	110563843
Cerebral artery thrombosis	23.26	21.95	10	24722	1658	110562909
Gait disturbance	23.20	21.95	17	24715	278191	110286376
Vascular access site haematoma	22.81	21.95	4	24728	18	110564549
Extrasystoles	22.48	21.95	17	24715	8301	110556266
Quadriplegia	22.31	21.95	13	24719	4114	110560453
Infection	22.27	21.95	29	24703	362171	110202396
Peripheral ischaemia	22.22	21.95	19	24713	11039	110553528
NIH stroke scale score decreased	22.22	21.95	3	24729	0	110564567
Factor I deficiency	22.22	21.95	3	24729	0	110564567
Mucosal inflammation	22.09	21.95	59	24673	96082	110468485

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B01AD02	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Enzymes
ATC	S01XA13	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D005343	Fibrinolytic Agents
MeSH PA	D006401	Hematologic Agents
CHEBI has role	CHEBI:22587	antiviral agent
CHEBI has role	CHEBI:35441	antiinfective agent
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:50249	anticoagulant
CHEBI has role	CHEBI:66981	ophthalmology drug

Related Drugs by ATC class:

B01AD Enzymes 4 drugs

cinaxadamtase alfareteplasetenecteplaseurokinase

S01XA Other ophthalmologicals 24 drugs

acetylcysteinealumascorbic acidavacincaptad pegolcenegerminciclosporindexpanthenoldiquafosolethylmorphineguaiazulenheparininosine show all 24 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Acute myocardial infarction	indication	57054005	DOID:9408
Pulmonary embolism	indication	59282003	DOID:9477
Ischemic stroke	indication	422504002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Plasminogen	Enzyme	P00747	PLMN_HUMAN	ACTIVATOR				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
1RXS4UE564	UNII
4019319	VANDF
4019599	VANDF
C0032143	UMLSCUI
CHEBI:749459	CHEBI
CHEMBL1201593	ChEMBL_ID
D02837	KEGG_DRUG
DB00009	DRUGBANK_ID
5975	INN_ID
204210	RXNORM
4155	MMSL
970	MMSL
d00521	MMSL
002074	NDDF
108997009	SNOMEDCT_US
27638005	SNOMEDCT_US
37411004	SNOMEDCT_US
387152000	SNOMEDCT_US
D010959	MESH_DESCRIPTOR_UI
1RXS4UE564	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Cathflo Activase	HUMAN PRESCRIPTION DRUG LABEL	1	50242-041	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	2.20 mg	INTRAVENOUS	BLA	21 sections