Stem definition | Drug id | CAS RN |
---|---|---|
enzymes | 5141 | 105857-23-6 |
Molecule | Description |
---|---|
Synonyms:
|
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases. Is currently clinical tested as treatment for COVID-19 patients.
|
Dose | Unit | Route |
---|---|---|
0.10 | g | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
June 18, 1996 | FDA | GENENTECH |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Haemorrhagic transformation stroke | 908.35 | 24.72 | 157 | 8025 | 952 | 50595990 |
Angioedema | 771.76 | 24.72 | 272 | 7910 | 37404 | 50559538 |
Cerebral haemorrhage | 769.55 | 24.72 | 250 | 7932 | 26802 | 50570140 |
Haemorrhage intracranial | 629.34 | 24.72 | 179 | 8003 | 12195 | 50584747 |
Death | 278.68 | 24.72 | 300 | 7882 | 325079 | 50271863 |
Haemorrhage | 202.49 | 24.72 | 119 | 8063 | 53322 | 50543620 |
No adverse event | 162.98 | 24.72 | 88 | 8094 | 33490 | 50563452 |
Cerebral haematoma | 130.06 | 24.72 | 39 | 8143 | 3172 | 50593770 |
Swollen tongue | 127.75 | 24.72 | 71 | 8111 | 28559 | 50568383 |
Neurological decompensation | 124.96 | 24.72 | 35 | 8147 | 2235 | 50594707 |
Subarachnoid haemorrhage | 119.73 | 24.72 | 50 | 8132 | 10726 | 50586216 |
Cerebral infarction | 111.46 | 24.72 | 59 | 8123 | 21545 | 50575397 |
NIH stroke scale score increased | 108.23 | 24.72 | 14 | 8168 | 0 | 50596942 |
Intraventricular haemorrhage | 103.69 | 24.72 | 29 | 8153 | 1841 | 50595101 |
Brain herniation | 97.50 | 24.72 | 31 | 8151 | 3061 | 50593881 |
Thrombolysis | 89.27 | 24.72 | 15 | 8167 | 74 | 50596868 |
Aplastic anaemia | 83.07 | 24.72 | 35 | 8147 | 7668 | 50589274 |
Hemiparesis | 82.04 | 24.72 | 47 | 8135 | 20001 | 50576941 |
Intracranial mass | 78.97 | 24.72 | 21 | 8161 | 1102 | 50595840 |
Brain oedema | 75.97 | 24.72 | 38 | 8144 | 12332 | 50584610 |
Stroke in evolution | 67.34 | 24.72 | 11 | 8171 | 44 | 50596898 |
Haemorrhagic cerebral infarction | 65.38 | 24.72 | 16 | 8166 | 600 | 50596342 |
NIH stroke scale abnormal | 59.30 | 24.72 | 8 | 8174 | 3 | 50596939 |
Brain stem haemorrhage | 57.81 | 24.72 | 15 | 8167 | 715 | 50596227 |
Aphasia | 57.74 | 24.72 | 43 | 8139 | 28451 | 50568491 |
Tongue oedema | 57.14 | 24.72 | 22 | 8160 | 3817 | 50593125 |
Product quality issue | 56.87 | 24.72 | 44 | 8138 | 30814 | 50566128 |
Cardiogenic shock | 51.88 | 24.72 | 32 | 8150 | 15567 | 50581375 |
Cerebral mass effect | 51.35 | 24.72 | 14 | 8168 | 808 | 50596134 |
Haemorrhagic infarction | 50.08 | 24.72 | 11 | 8171 | 254 | 50596688 |
Respiratory failure | 49.35 | 24.72 | 67 | 8115 | 91114 | 50505828 |
Ventricular extrasystoles | 46.65 | 24.72 | 26 | 8156 | 10490 | 50586452 |
Haematoma | 46.64 | 24.72 | 39 | 8143 | 30471 | 50566471 |
Reperfusion arrhythmia | 45.61 | 24.72 | 10 | 8172 | 229 | 50596713 |
Lip swelling | 44.98 | 24.72 | 35 | 8147 | 24701 | 50572241 |
Cerebral hyperperfusion syndrome | 44.67 | 24.72 | 7 | 8175 | 20 | 50596922 |
Ischaemic stroke | 43.80 | 24.72 | 29 | 8153 | 15919 | 50581023 |
Hypotension | 41.93 | 24.72 | 107 | 8075 | 235362 | 50361580 |
Diarrhoea | 37.04 | 24.72 | 25 | 8157 | 588451 | 50008491 |
Coma | 35.73 | 24.72 | 45 | 8137 | 56834 | 50540108 |
Hemiplegia | 34.80 | 24.72 | 19 | 8163 | 7362 | 50589580 |
Intra-abdominal haemorrhage | 34.03 | 24.72 | 13 | 8169 | 2207 | 50594735 |
Arthralgia | 32.82 | 24.72 | 15 | 8167 | 438687 | 50158255 |
Ventricular tachycardia | 32.32 | 24.72 | 24 | 8158 | 15797 | 50581145 |
Cardiac tamponade | 32.01 | 24.72 | 15 | 8167 | 4217 | 50592725 |
Chest pain | 31.05 | 24.72 | 80 | 8102 | 176802 | 50420140 |
Anaphylactic reaction | 29.64 | 24.72 | 40 | 8142 | 54015 | 50542927 |
Procedural haemorrhage | 29.62 | 24.72 | 12 | 8170 | 2378 | 50594564 |
Reocclusion | 28.68 | 24.72 | 4 | 8178 | 3 | 50596939 |
Bradycardia | 28.45 | 24.72 | 43 | 8139 | 64383 | 50532559 |
Haemothorax | 28.31 | 24.72 | 11 | 8171 | 1955 | 50594987 |
Extravasation | 28.12 | 24.72 | 11 | 8171 | 1991 | 50594951 |
Cardiac arrest | 27.68 | 24.72 | 49 | 8133 | 83602 | 50513340 |
Blood fibrinogen decreased | 26.76 | 24.72 | 8 | 8174 | 643 | 50596299 |
Haemorrhagic stroke | 26.16 | 24.72 | 14 | 8168 | 5214 | 50591728 |
Reperfusion injury | 26.15 | 24.72 | 5 | 8177 | 56 | 50596886 |
Myocardial rupture | 26.07 | 24.72 | 5 | 8177 | 57 | 50596885 |
Macular hole | 25.71 | 24.72 | 8 | 8174 | 735 | 50596207 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Haemorrhagic transformation stroke | 1163.06 | 20.00 | 224 | 10284 | 1082 | 29562937 |
Haemorrhage intracranial | 654.45 | 20.00 | 231 | 10277 | 14311 | 29549708 |
Cerebral haemorrhage | 591.67 | 20.00 | 266 | 10242 | 31160 | 29532859 |
Angioedema | 463.80 | 20.00 | 226 | 10282 | 31689 | 29532330 |
Ventricular extrasystoles | 215.96 | 20.00 | 95 | 10413 | 10487 | 29553532 |
Haemorrhage | 204.70 | 20.00 | 151 | 10357 | 44921 | 29519098 |
Haemorrhagic infarction | 177.38 | 20.00 | 39 | 10469 | 391 | 29563628 |
Death | 154.09 | 20.00 | 359 | 10149 | 341725 | 29222294 |
No adverse event | 146.54 | 20.00 | 86 | 10422 | 17392 | 29546627 |
Neurological decompensation | 137.24 | 20.00 | 46 | 10462 | 2416 | 29561603 |
Ventricular tachycardia | 131.11 | 20.00 | 88 | 10420 | 22486 | 29541533 |
NIH stroke scale score increased | 119.08 | 20.00 | 18 | 10490 | 7 | 29564012 |
Chest pain | 108.81 | 20.00 | 164 | 10344 | 111809 | 29452210 |
Cerebral infarction | 108.11 | 20.00 | 81 | 10427 | 24594 | 29539425 |
Intraventricular haemorrhage | 107.38 | 20.00 | 40 | 10468 | 2866 | 29561153 |
Brain oedema | 104.69 | 20.00 | 61 | 10447 | 12159 | 29551860 |
Haematoma | 92.45 | 20.00 | 72 | 10436 | 23140 | 29540879 |
Cerebral haematoma | 88.98 | 20.00 | 39 | 10469 | 4257 | 29559762 |
Aplastic anaemia | 87.73 | 20.00 | 46 | 10462 | 7464 | 29556555 |
Subarachnoid haemorrhage | 84.65 | 20.00 | 49 | 10459 | 9643 | 29554376 |
Hemiparesis | 82.94 | 20.00 | 56 | 10452 | 14430 | 29549589 |
Reperfusion arrhythmia | 81.28 | 20.00 | 15 | 10493 | 54 | 29563965 |
Haemorrhagic stroke | 74.53 | 20.00 | 38 | 10470 | 5818 | 29558201 |
Ischaemic stroke | 68.95 | 20.00 | 52 | 10456 | 15925 | 29548094 |
Thrombolysis | 66.19 | 20.00 | 13 | 10495 | 70 | 29563949 |
Swollen tongue | 64.49 | 20.00 | 45 | 10463 | 12221 | 29551798 |
Extrasystoles | 63.82 | 20.00 | 29 | 10479 | 3445 | 29560574 |
Cerebral mass effect | 63.48 | 20.00 | 20 | 10488 | 861 | 29563158 |
Brain herniation | 62.58 | 20.00 | 29 | 10479 | 3604 | 29560415 |
Haemorrhagic cerebral infarction | 62.53 | 20.00 | 19 | 10489 | 724 | 29563295 |
Stroke in evolution | 58.46 | 20.00 | 10 | 10498 | 20 | 29563999 |
Bradycardia | 52.39 | 20.00 | 88 | 10420 | 65541 | 29498478 |
Tongue oedema | 52.18 | 20.00 | 23 | 10485 | 2543 | 29561476 |
Aphasia | 50.61 | 20.00 | 47 | 10461 | 19151 | 29544868 |
Hypotension | 48.22 | 20.00 | 165 | 10343 | 194189 | 29369830 |
Cerebral hyperperfusion syndrome | 47.83 | 20.00 | 10 | 10498 | 77 | 29563942 |
Electrocardiogram ST segment elevation | 45.41 | 20.00 | 25 | 10483 | 4467 | 29559552 |
Diarrhoea | 44.75 | 20.00 | 32 | 10476 | 332666 | 29231353 |
Gingival bleeding | 44.39 | 20.00 | 28 | 10480 | 6425 | 29557594 |
Ventricular fibrillation | 44.14 | 20.00 | 40 | 10468 | 15793 | 29548226 |
Intentional product use issue | 42.20 | 20.00 | 63 | 10445 | 42435 | 29521584 |
Toxicity to various agents | 41.87 | 20.00 | 6 | 10502 | 173655 | 29390364 |
Hemiplegia | 41.37 | 20.00 | 27 | 10481 | 6567 | 29557452 |
Basal ganglia haemorrhage | 40.92 | 20.00 | 14 | 10494 | 782 | 29563237 |
Cardiac arrest | 40.44 | 20.00 | 92 | 10416 | 85499 | 29478520 |
Cerebral artery occlusion | 38.73 | 20.00 | 13 | 10495 | 685 | 29563334 |
Brain stem haemorrhage | 35.92 | 20.00 | 13 | 10495 | 857 | 29563162 |
Reocclusion | 33.10 | 20.00 | 6 | 10502 | 19 | 29564000 |
Paresis | 32.55 | 20.00 | 15 | 10493 | 1839 | 29562180 |
Aortic dissection | 31.88 | 20.00 | 16 | 10492 | 2368 | 29561651 |
Blood fibrinogen decreased | 31.60 | 20.00 | 12 | 10496 | 906 | 29563113 |
Intracranial pressure increased | 31.43 | 20.00 | 18 | 10490 | 3467 | 29560552 |
Haemothorax | 29.01 | 20.00 | 17 | 10491 | 3419 | 29560600 |
Catheter site haemorrhage | 28.13 | 20.00 | 14 | 10494 | 2034 | 29561985 |
Product closure issue | 27.77 | 20.00 | 4 | 10504 | 0 | 29564019 |
Malaise | 27.77 | 20.00 | 11 | 10497 | 159591 | 29404428 |
Extravasation | 27.72 | 20.00 | 13 | 10495 | 1659 | 29562360 |
Rhythm idioventricular | 27.14 | 20.00 | 8 | 10500 | 274 | 29563745 |
Tongue haemorrhage | 26.58 | 20.00 | 9 | 10499 | 487 | 29563532 |
Lip swelling | 26.36 | 20.00 | 27 | 10481 | 12383 | 29551636 |
Epistaxis | 25.98 | 20.00 | 57 | 10451 | 51647 | 29512372 |
Cardiogenic shock | 25.89 | 20.00 | 33 | 10475 | 19157 | 29544862 |
Product quality issue | 25.78 | 20.00 | 30 | 10478 | 15865 | 29548154 |
Parotid gland haemorrhage | 25.77 | 20.00 | 5 | 10503 | 25 | 29563994 |
Reperfusion injury | 25.71 | 20.00 | 6 | 10502 | 80 | 29563939 |
Fatigue | 25.62 | 20.00 | 46 | 10462 | 316775 | 29247244 |
Cerebral ischaemia | 25.57 | 20.00 | 19 | 10489 | 5684 | 29558335 |
Cardiac ventricular thrombosis | 24.34 | 20.00 | 10 | 10498 | 929 | 29563090 |
Fall | 23.80 | 20.00 | 17 | 10491 | 177161 | 29386858 |
Hydrocephalus | 23.03 | 20.00 | 16 | 10492 | 4311 | 29559708 |
Coma | 22.73 | 20.00 | 46 | 10462 | 39404 | 29524615 |
Arrhythmia | 22.35 | 20.00 | 40 | 10468 | 31273 | 29532746 |
Myocardial rupture | 21.65 | 20.00 | 6 | 10502 | 164 | 29563855 |
Mouth haemorrhage | 21.60 | 20.00 | 16 | 10492 | 4764 | 29559255 |
Weight decreased | 20.89 | 20.00 | 14 | 10494 | 150891 | 29413128 |
Injection site oedema | 20.87 | 20.00 | 6 | 10502 | 188 | 29563831 |
Pericardial haemorrhage | 20.87 | 20.00 | 13 | 10495 | 2918 | 29561101 |
Factor I deficiency | 20.83 | 20.00 | 3 | 10505 | 0 | 29564019 |
Hyperhidrosis | 20.71 | 20.00 | 60 | 10448 | 64480 | 29499539 |
Hemianopia | 20.56 | 20.00 | 8 | 10500 | 645 | 29563374 |
Shock | 20.19 | 20.00 | 31 | 10477 | 21373 | 29542646 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Haemorrhagic transformation stroke | 1915.48 | 21.22 | 353 | 15273 | 2036 | 64481070 |
Cerebral haemorrhage | 1243.82 | 21.22 | 466 | 15160 | 50624 | 64432482 |
Haemorrhage intracranial | 1083.10 | 21.22 | 347 | 15279 | 23537 | 64459569 |
Angioedema | 1061.31 | 21.22 | 438 | 15188 | 61383 | 64421723 |
Haemorrhage | 295.79 | 21.22 | 203 | 15423 | 79148 | 64403958 |
Cerebral haematoma | 275.01 | 21.22 | 92 | 15534 | 7093 | 64476013 |
Neurological decompensation | 257.47 | 21.22 | 78 | 15548 | 4358 | 64478748 |
Death | 236.92 | 21.22 | 420 | 15206 | 482285 | 64000821 |
No adverse event | 229.71 | 21.22 | 120 | 15506 | 28441 | 64454665 |
Cerebral infarction | 227.57 | 21.22 | 135 | 15491 | 40909 | 64442197 |
NIH stroke scale score increased | 225.76 | 21.22 | 32 | 15594 | 10 | 64483096 |
Subarachnoid haemorrhage | 203.23 | 21.22 | 96 | 15530 | 18342 | 64464764 |
Intraventricular haemorrhage | 178.26 | 21.22 | 58 | 15568 | 4095 | 64479011 |
Brain oedema | 178.19 | 21.22 | 93 | 15533 | 21982 | 64461124 |
Aplastic anaemia | 167.42 | 21.22 | 77 | 15549 | 13843 | 64469263 |
Brain herniation | 163.45 | 21.22 | 61 | 15565 | 6472 | 64476634 |
Haemorrhagic cerebral infarction | 163.43 | 21.22 | 42 | 15584 | 1272 | 64481834 |
Swollen tongue | 158.10 | 21.22 | 101 | 15525 | 34853 | 64448253 |
Hemiparesis | 152.07 | 21.22 | 93 | 15533 | 29734 | 64453372 |
Thrombolysis | 152.01 | 21.22 | 28 | 15598 | 159 | 64482947 |
Haemorrhagic infarction | 135.66 | 21.22 | 32 | 15594 | 673 | 64482433 |
Cerebral mass effect | 134.26 | 21.22 | 38 | 15588 | 1668 | 64481438 |
Haematoma | 123.80 | 21.22 | 97 | 15529 | 46153 | 64436953 |
Stroke in evolution | 115.38 | 21.22 | 20 | 15606 | 75 | 64483031 |
Aphasia | 105.62 | 21.22 | 84 | 15542 | 40822 | 64442284 |
Ventricular extrasystoles | 100.60 | 21.22 | 59 | 15567 | 17470 | 64465636 |
Intracranial mass | 93.66 | 21.22 | 30 | 15596 | 2013 | 64481093 |
Haemorrhagic stroke | 92.11 | 21.22 | 46 | 15580 | 9905 | 64473201 |
Cerebral hyperperfusion syndrome | 91.63 | 21.22 | 17 | 15609 | 101 | 64483005 |
Ventricular tachycardia | 87.67 | 21.22 | 70 | 15556 | 34195 | 64448911 |
Tongue oedema | 87.57 | 21.22 | 38 | 15588 | 5952 | 64477154 |
Brain stem haemorrhage | 84.56 | 21.22 | 26 | 15600 | 1525 | 64481581 |
NIH stroke scale abnormal | 75.80 | 21.22 | 11 | 15615 | 6 | 64483100 |
Product quality issue | 74.36 | 21.22 | 60 | 15566 | 29739 | 64453367 |
Ischaemic stroke | 73.60 | 21.22 | 59 | 15567 | 28976 | 64454130 |
Hemiplegia | 70.70 | 21.22 | 42 | 15584 | 12726 | 64470380 |
Diarrhoea | 69.50 | 21.22 | 45 | 15581 | 722659 | 63760447 |
Reperfusion arrhythmia | 65.43 | 21.22 | 15 | 15611 | 277 | 64482829 |
Aortic dissection | 64.22 | 21.22 | 26 | 15600 | 3426 | 64479680 |
Cardiogenic shock | 63.89 | 21.22 | 57 | 15569 | 32370 | 64450736 |
Toxicity to various agents | 63.55 | 21.22 | 7 | 15619 | 363506 | 64119600 |
Cardiac arrest | 62.44 | 21.22 | 124 | 15502 | 153940 | 64329166 |
Lip swelling | 60.72 | 21.22 | 55 | 15571 | 31852 | 64451254 |
Haemothorax | 58.87 | 21.22 | 27 | 15599 | 4815 | 64478291 |
Basal ganglia haemorrhage | 57.76 | 21.22 | 19 | 15607 | 1387 | 64481719 |
Fatigue | 55.49 | 21.22 | 60 | 15566 | 748670 | 63734436 |
Respiratory failure | 55.11 | 21.22 | 121 | 15505 | 161062 | 64322044 |
Arthralgia | 50.55 | 21.22 | 22 | 15604 | 442238 | 64040868 |
Hydrocephalus | 50.10 | 21.22 | 28 | 15598 | 7563 | 64475543 |
Reperfusion injury | 49.23 | 21.22 | 11 | 15615 | 180 | 64482926 |
Intentional product use issue | 48.95 | 21.22 | 85 | 15541 | 95279 | 64387827 |
Cerebral artery occlusion | 47.56 | 21.22 | 17 | 15609 | 1594 | 64481512 |
Hypotension | 47.33 | 21.22 | 200 | 15426 | 380774 | 64102332 |
Intracranial pressure increased | 46.73 | 21.22 | 26 | 15600 | 6963 | 64476143 |
Coma | 46.16 | 21.22 | 79 | 15547 | 87536 | 64395570 |
Cardiac tamponade | 45.57 | 21.22 | 27 | 15599 | 8137 | 64474969 |
Intra-abdominal haemorrhage | 44.42 | 21.22 | 21 | 15605 | 4010 | 64479096 |
Malaise | 43.26 | 21.22 | 21 | 15605 | 396226 | 64086880 |
Blood fibrinogen decreased | 41.59 | 21.22 | 15 | 15611 | 1443 | 64481663 |
Product closure issue | 40.89 | 21.22 | 6 | 15620 | 4 | 64483102 |
Fall | 39.89 | 21.22 | 26 | 15600 | 416800 | 64066306 |
Anaphylactic reaction | 38.94 | 21.22 | 64 | 15562 | 68600 | 64414506 |
Epistaxis | 38.54 | 21.22 | 78 | 15548 | 98053 | 64385053 |
Pericardial haemorrhage | 37.92 | 21.22 | 19 | 15607 | 4117 | 64478989 |
Pulseless electrical activity | 36.85 | 21.22 | 28 | 15598 | 12711 | 64470395 |
Tongue haemorrhage | 36.81 | 21.22 | 12 | 15614 | 851 | 64482255 |
Myocardial rupture | 36.48 | 21.22 | 9 | 15617 | 230 | 64482876 |
Extravasation | 36.38 | 21.22 | 17 | 15609 | 3163 | 64479943 |
Nasopharyngitis | 36.28 | 21.22 | 3 | 15623 | 196070 | 64287036 |
Mouth haemorrhage | 36.20 | 21.22 | 25 | 15601 | 9794 | 64473312 |
Catheter site haemorrhage | 36.05 | 21.22 | 19 | 15607 | 4572 | 64478534 |
Gingival bleeding | 35.14 | 21.22 | 29 | 15597 | 14825 | 64468281 |
Hemianopia | 33.55 | 21.22 | 13 | 15613 | 1526 | 64481580 |
Weight decreased | 32.95 | 21.22 | 14 | 15612 | 285725 | 64197381 |
Cerebral artery embolism | 32.95 | 21.22 | 13 | 15613 | 1601 | 64481505 |
Shock | 32.31 | 21.22 | 43 | 15583 | 38197 | 64444909 |
Heparin-induced thrombocytopenia | 32.23 | 21.22 | 22 | 15604 | 8457 | 64474649 |
Bradycardia | 31.94 | 21.22 | 81 | 15545 | 118138 | 64364968 |
Paresis | 31.72 | 21.22 | 16 | 15610 | 3516 | 64479590 |
Procedural haemorrhage | 31.70 | 21.22 | 17 | 15609 | 4235 | 64478871 |
Embolism | 31.29 | 21.22 | 25 | 15601 | 12210 | 64470896 |
Vitreous haemorrhage | 30.74 | 21.22 | 15 | 15611 | 3070 | 64480036 |
Macular hole | 30.48 | 21.22 | 10 | 15616 | 724 | 64482382 |
Brain death | 29.57 | 21.22 | 17 | 15609 | 4844 | 64478262 |
Drug intolerance | 29.55 | 21.22 | 5 | 15621 | 187987 | 64295119 |
Embolic stroke | 29.35 | 21.22 | 19 | 15607 | 6692 | 64476414 |
Completed suicide | 29.25 | 21.22 | 9 | 15617 | 224405 | 64258701 |
Cytokine release syndrome | 28.54 | 21.22 | 30 | 15596 | 20799 | 64462307 |
Hypofibrinogenaemia | 28.36 | 21.22 | 12 | 15614 | 1766 | 64481340 |
Myalgia | 27.82 | 21.22 | 3 | 15623 | 158614 | 64324492 |
Parotid gland haemorrhage | 27.51 | 21.22 | 5 | 15621 | 26 | 64483080 |
Coagulopathy | 27.13 | 21.22 | 36 | 15590 | 31884 | 64451222 |
Chest pain | 27.02 | 21.22 | 121 | 15505 | 235859 | 64247247 |
Carotid artery occlusion | 27.01 | 21.22 | 15 | 15611 | 4002 | 64479104 |
Cerebral artery thrombosis | 26.89 | 21.22 | 10 | 15616 | 1049 | 64482057 |
Cerebellar haemorrhage | 26.81 | 21.22 | 13 | 15613 | 2624 | 64480482 |
Lip oedema | 25.96 | 21.22 | 16 | 15610 | 5173 | 64477933 |
Electrocardiogram ST segment elevation | 25.63 | 21.22 | 18 | 15608 | 7241 | 64475865 |
Monoparesis | 25.50 | 21.22 | 13 | 15613 | 2921 | 64480185 |
Intracardiac thrombus | 25.10 | 21.22 | 14 | 15612 | 3767 | 64479339 |
Retroperitoneal haematoma | 24.79 | 21.22 | 15 | 15611 | 4696 | 64478410 |
Extrasystoles | 24.66 | 21.22 | 17 | 15609 | 6641 | 64476465 |
Depression | 24.52 | 21.22 | 7 | 15619 | 183284 | 64299822 |
Pruritus | 24.21 | 21.22 | 24 | 15602 | 312376 | 64170730 |
Cardiac ventricular thrombosis | 24.04 | 21.22 | 10 | 15616 | 1410 | 64481696 |
Reocclusion | 23.76 | 21.22 | 4 | 15622 | 12 | 64483094 |
Facial paralysis | 23.67 | 21.22 | 26 | 15600 | 18940 | 64464166 |
Pain | 23.67 | 21.22 | 63 | 15563 | 553448 | 63929658 |
Compartment syndrome | 23.63 | 21.22 | 14 | 15612 | 4218 | 64478888 |
Cerebral artery stenosis | 23.48 | 21.22 | 8 | 15618 | 651 | 64482455 |
Product dose omission issue | 23.32 | 21.22 | 9 | 15617 | 194738 | 64288368 |
Peripheral artery occlusion | 23.14 | 21.22 | 11 | 15615 | 2127 | 64480979 |
Rash | 22.94 | 21.22 | 48 | 15578 | 458501 | 64024605 |
Cerebral ischaemia | 22.63 | 21.22 | 19 | 15607 | 9943 | 64473163 |
Thyroid haemorrhage | 22.60 | 21.22 | 5 | 15621 | 78 | 64483028 |
Abdominal discomfort | 22.54 | 21.22 | 8 | 15618 | 182314 | 64300792 |
Quadriplegia | 22.33 | 21.22 | 12 | 15614 | 3001 | 64480105 |
Insomnia | 22.30 | 21.22 | 10 | 15616 | 197826 | 64285280 |
Weight increased | 22.21 | 21.22 | 12 | 15614 | 213336 | 64269770 |
Paralysis | 22.08 | 21.22 | 20 | 15606 | 11575 | 64471531 |
Endotracheal intubation | 22.05 | 21.22 | 13 | 15613 | 3882 | 64479224 |
Factor I deficiency | 21.98 | 21.22 | 3 | 15623 | 0 | 64483106 |
Ventricular fibrillation | 21.97 | 21.22 | 28 | 15598 | 23832 | 64459274 |
Dysarthria | 21.87 | 21.22 | 46 | 15580 | 59360 | 64423746 |
Cerebral reperfusion injury | 21.82 | 21.22 | 4 | 15622 | 22 | 64483084 |
Stridor | 21.81 | 21.22 | 14 | 15612 | 4860 | 64478246 |
Decreased appetite | 21.34 | 21.22 | 22 | 15604 | 281267 | 64201839 |
Asthenia | 21.24 | 21.22 | 45 | 15581 | 427999 | 64055107 |
None
Source | Code | Description |
---|---|---|
ATC | B01AD02 | BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Enzymes |
ATC | S01XA13 | SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D005343 | Fibrinolytic Agents |
MeSH PA | D006401 | Hematologic Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute myocardial infarction | indication | 57054005 | DOID:9408 |
Pulmonary embolism | indication | 59282003 | DOID:9477 |
Ischemic stroke | indication | 422504002 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Plasminogen | Enzyme | ACTIVATOR | DRUG LABEL | DRUG LABEL |
ID | Source |
---|---|
1RXS4UE564 | UNII |
4019319 | VANDF |
4019599 | VANDF |
C0032143 | UMLSCUI |
CHEMBL1201593 | ChEMBL_ID |
D02837 | KEGG_DRUG |
DB00009 | DRUGBANK_ID |
5975 | INN_ID |
204210 | RXNORM |
4155 | MMSL |
970 | MMSL |
d00521 | MMSL |
108997009 | SNOMEDCT_US |
27638005 | SNOMEDCT_US |
37411004 | SNOMEDCT_US |
387152000 | SNOMEDCT_US |
D010959 | MESH_DESCRIPTOR_UI |
002074 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Cathflo Activase | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-041 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 2.20 mg | INTRAVENOUS | BLA | 21 sections |