alteplase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
enzymes	5141	105857-23-6

Description:

Molecule	Description
Synonyms: alteplase activase alteplase (genetical recombination)	A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases. Is currently clinical tested as treatment for COVID-19 patients. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

alteplase
activase
alteplase (genetical recombination)

A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases. Is currently clinical tested as treatment for COVID-19 patients.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
0.10	g	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
June 18, 1996	FDA	GENENTECH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Haemorrhagic transformation stroke	1034.27	24.70	175	8897	1060	63478890
Cerebral haemorrhage	904.67	24.70	283	8789	30446	63449504
Angioedema	845.34	24.70	300	8772	47665	63432285
Haemorrhage intracranial	677.90	24.70	188	8884	13231	63466719
Death	300.81	24.70	315	8757	374066	63105884
No adverse event	244.79	24.70	119	8953	41286	63438664
Haemorrhage	230.79	24.70	130	8942	60892	63419058
Aplastic anaemia	146.03	24.70	54	9018	9515	63470435
Cerebral haematoma	142.57	24.70	42	9030	3641	63476309
Cerebral infarction	142.08	24.70	69	9003	23824	63456126
Swollen tongue	136.49	24.70	76	8996	34724	63445226
Subarachnoid haemorrhage	135.00	24.70	57	9015	14226	63465724
Neurological decompensation	133.15	24.70	37	9035	2601	63477349
Intraventricular haemorrhage	112.83	24.70	31	9041	2089	63477861
Brain herniation	112.55	24.70	35	9037	3642	63476308
NIH stroke scale score increased	109.96	24.70	14	9058	0	63479950
Hemiparesis	88.95	24.70	50	9022	23232	63456718
Thrombolysis	85.21	24.70	15	9057	117	63479833
Brain oedema	84.37	24.70	41	9031	14154	63465796
NIH stroke scale abnormal	81.61	24.70	11	9061	6	63479944
Intracranial mass	80.04	24.70	21	9051	1186	63478764
Haemorrhagic cerebral infarction	76.91	24.70	18	9054	632	63479318
Cerebral mass effect	70.84	24.70	18	9054	895	63479055
Stroke in evolution	67.21	24.70	11	9061	52	63479898
Lip swelling	66.10	24.70	46	9026	31017	63448933
Product quality issue	62.38	24.70	47	9025	35818	63444132
Tongue oedema	59.52	24.70	23	9049	4563	63475387
Aphasia	59.07	24.70	44	9028	32956	63446994
Brain stem haemorrhage	58.93	24.70	15	9057	751	63479199
Respiratory failure	57.85	24.70	72	9000	101786	63378164
Cardiogenic shock	53.95	24.70	33	9039	17899	63462051
Haematoma	50.52	24.70	41	9031	34779	63445171
Haemorrhagic infarction	50.18	24.70	11	9061	286	63479664
Ischaemic stroke	48.85	24.70	31	9041	17926	63462024
Ventricular extrasystoles	47.08	24.70	26	9046	11661	63468289
Reperfusion arrhythmia	46.63	24.70	10	9062	234	63479716
Cerebral hyperperfusion syndrome	45.53	24.70	7	9065	20	63479930
Hypotension	44.48	24.70	111	8961	272493	63207457
Haemothorax	43.41	24.70	15	9057	2170	63477780
Diarrhoea	40.95	24.70	26	9046	715340	62764610
Intra-abdominal haemorrhage	37.90	24.70	14	9058	2455	63477495
Coma	37.32	24.70	46	9026	64318	63415632
Reocclusion	36.92	24.70	5	9067	3	63479947
Cardiac arrest	35.29	24.70	54	9018	92491	63387459
Haemorrhagic stroke	35.22	24.70	17	9055	5775	63474175
Extravasation	34.76	24.70	13	9059	2359	63477591
Procedural haemorrhage	33.18	24.70	13	9059	2675	63477275
Hemiplegia	32.84	24.70	19	9053	9304	63470646
Heparin-induced thrombocytopenia	32.64	24.70	15	9057	4567	63475383
Abdominal discomfort	32.19	24.70	4	9068	320881	63159069
Arthralgia	32.16	24.70	21	9051	569689	62910261
Ventricular tachycardia	32.13	24.70	25	9047	19954	63459996
Cardiac tamponade	32.05	24.70	15	9057	4760	63475190
Blood fibrinogen decreased	29.84	24.70	9	9063	844	63479106
Bradycardia	29.72	24.70	44	9028	73183	63406767
Chest pain	29.14	24.70	82	8990	215877	63264073
Basal ganglia haemorrhage	27.70	24.70	8	9064	646	63479304
Anaphylactic reaction	27.23	24.70	40	9032	66060	63413890
Brain death	26.94	24.70	12	9060	3398	63476552
Shock	26.62	24.70	24	9048	23439	63456511
Myocardial rupture	26.23	24.70	5	9067	63	63479887
Reperfusion injury	26.01	24.70	5	9067	66	63479884
Nasopharyngitis	25.91	24.70	3	9069	254254	63225696
Retroperitoneal haemorrhage	25.87	24.70	11	9061	2786	63477164
Macular hole	25.76	24.70	8	9064	828	63479122
Product temperature excursion issue	25.60	24.70	6	9066	212	63479738
Hydrocephalus	24.72	24.70	13	9059	5287	63474663

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Haemorrhagic transformation stroke	1298.69	20.72	249	11317	1274	34944091
Haemorrhage intracranial	699.26	20.72	244	11322	15702	34929663
Cerebral haemorrhage	695.36	20.72	301	11265	34636	34910729
Angioedema	522.52	20.72	252	11314	37122	34908243
Haemorrhage	218.89	20.72	161	11405	51209	34894156
Ventricular extrasystoles	214.08	20.72	96	11470	11912	34933453
No adverse event	205.73	20.72	115	11451	22812	34922553
Haemorrhagic infarction	192.76	20.72	42	11524	435	34944930
Death	150.64	20.72	374	11192	397675	34547690
Neurological decompensation	135.92	20.72	47	11519	2919	34942446
NIH stroke scale score increased	131.54	20.72	20	11546	11	34945354
Cerebral infarction	125.77	20.72	90	11476	27365	34918000
Ventricular tachycardia	123.75	20.72	88	11478	26491	34918874
Brain oedema	120.30	20.72	68	11498	13753	34931612
Intraventricular haemorrhage	116.91	20.72	44	11522	3487	34941878
Cerebral haematoma	115.68	20.72	47	11519	4568	34940797
Aplastic anaemia	104.51	20.72	55	11511	9661	34935704
Chest pain	103.60	20.72	165	11401	126597	34818768
Hemiparesis	94.31	20.72	61	11505	15717	34929648
Subarachnoid haemorrhage	93.61	20.72	56	11510	12579	34932786
Haematoma	92.87	20.72	73	11493	25532	34919833
Haemorrhagic cerebral infarction	82.45	20.72	24	11542	847	34944518
Reperfusion arrhythmia	81.71	20.72	15	11551	57	34945308
Brain herniation	80.93	20.72	35	11531	3973	34941392
Gingival bleeding	76.34	20.72	40	11526	6960	34938405
Haemorrhagic stroke	76.00	20.72	39	11527	6500	34938865
Ischaemic stroke	74.87	20.72	56	11510	18194	34927171
Swollen tongue	71.76	20.72	50	11516	14555	34930810
Cerebral mass effect	66.87	20.72	21	11545	962	34944403
Thrombolysis	64.96	20.72	13	11553	85	34945280
Extrasystoles	63.14	20.72	29	11537	3794	34941571
Stroke in evolution	61.43	20.72	11	11555	35	34945330
Aphasia	60.74	20.72	53	11513	21401	34923964
Tongue oedema	59.95	20.72	26	11540	2971	34942394
Cerebral artery occlusion	59.14	20.72	18	11548	742	34944623
Hemiplegia	54.50	20.72	32	11534	6940	34938425
Bradycardia	50.59	20.72	90	11476	75328	34870037
Diarrhoea	50.06	20.72	34	11532	389878	34555487
Cardiac arrest	50.04	20.72	103	11463	96056	34849309
Brain stem haemorrhage	47.50	20.72	16	11550	916	34944449
Cerebral hyperperfusion syndrome	47.45	20.72	10	11556	87	34945278
Hypotension	46.67	20.72	170	11396	221479	34723886
Toxicity to various agents	43.71	20.72	7	11559	200355	34745010
Electrocardiogram ST segment elevation	43.48	20.72	25	11541	5213	34940152
Basal ganglia haemorrhage	39.82	20.72	14	11552	912	34944453
Intracranial pressure increased	38.61	20.72	21	11545	3934	34941431
Product closure issue	37.93	20.72	6	11560	6	34945359
Ventricular fibrillation	34.10	20.72	40	11526	22914	34922451
Aortic dissection	33.59	20.72	17	11549	2751	34942614
Tongue haemorrhage	33.55	20.72	11	11555	579	34944786
Reocclusion	33.30	20.72	6	11560	20	34945345
NIH stroke scale abnormal	32.72	20.72	5	11561	3	34945362
Intentional product use issue	32.18	20.72	65	11501	59751	34885614
Paresis	31.21	20.72	15	11551	2171	34943194
Catheter site haemorrhage	30.97	20.72	15	11551	2209	34943156
Coma	29.94	20.72	54	11512	45624	34899741
Blood fibrinogen decreased	29.02	20.72	12	11554	1218	34944147
Fatigue	28.92	20.72	49	11517	370604	34574761
Malaise	28.39	20.72	13	11553	185812	34759553
Haemothorax	28.33	20.72	17	11549	3835	34941530
Product quality issue	27.51	20.72	31	11535	17004	34928361
Epistaxis	27.48	20.72	60	11506	58191	34887174
Cerebral ischaemia	27.26	20.72	20	11546	6302	34939063
Extravasation	27.08	20.72	13	11553	1877	34943488
Fall	26.89	20.72	17	11549	202868	34742497
Rhythm idioventricular	26.61	20.72	8	11558	316	34945049
Myocardial rupture	26.39	20.72	7	11559	174	34945191
Cardiac ventricular thrombosis	26.30	20.72	11	11555	1149	34944216
Reperfusion injury	26.14	20.72	6	11560	80	34945285
Hydrocephalus	25.89	20.72	18	11548	5214	34940151
Mouth haemorrhage	25.62	20.72	18	11548	5301	34940064
Parotid gland haemorrhage	25.35	20.72	5	11561	30	34945335
Hemianopia	24.25	20.72	9	11557	685	34944680
Lip swelling	23.84	20.72	28	11538	16052	34929313
Shock	23.23	20.72	34	11532	24145	34921220
Hyperhidrosis	23.07	20.72	66	11500	75626	34869739
Weight decreased	23.04	20.72	15	11551	176286	34769079
Neutropenia	22.38	20.72	12	11554	156766	34788599
Product dose omission issue	22.33	20.72	6	11560	119705	34825660
Respiratory failure	21.69	20.72	82	11484	108490	34836875
Paralysis	21.30	20.72	17	11549	6065	34939300
NIH stroke scale score decreased	21.04	20.72	3	11563	0	34945365
Factor I deficiency	21.04	20.72	3	11563	0	34945365
Pericardial haemorrhage	20.83	20.72	13	11553	3145	34942220

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Haemorrhagic transformation stroke	2147.75	21.41	390	17078	2302	79724618
Cerebral haemorrhage	1474.51	21.41	531	16937	57142	79669778
Angioedema	1190.15	21.41	490	16978	75545	79651375
Haemorrhage intracranial	1172.79	21.41	368	17100	25825	79701095
Haemorrhage	336.35	21.41	223	17245	90895	79636025
Cerebral haematoma	319.38	21.41	103	17365	7839	79719081
No adverse event	319.26	21.41	158	17310	37034	79689886
Cerebral infarction	277.61	21.41	154	17314	45522	79681398
Neurological decompensation	264.92	21.41	81	17387	5172	79721748
Death	249.07	21.41	444	17024	566070	79160850
Aplastic anaemia	244.39	21.41	105	17363	17800	79709120
NIH stroke scale score increased	238.75	21.41	34	17434	17	79726903
Subarachnoid haemorrhage	225.04	21.41	109	17359	24356	79702564
Brain herniation	202.31	21.41	72	17396	7391	79719529
Brain oedema	201.04	21.41	102	17366	25161	79701759
Intraventricular haemorrhage	198.99	21.41	64	17404	4823	79722097
Haemorrhagic cerebral infarction	197.32	21.41	49	17419	1430	79725490
Swollen tongue	176.04	21.41	112	17356	42458	79684462
Hemiparesis	170.77	21.41	101	17367	33632	79693288
Cerebral mass effect	161.41	21.41	44	17424	1862	79725058
Thrombolysis	145.62	21.41	28	17440	232	79726688
Haemorrhagic infarction	141.15	21.41	33	17435	741	79726179
Haematoma	128.52	21.41	100	17368	52095	79674825
Stroke in evolution	121.99	21.41	21	17447	85	79726835
Aphasia	118.25	21.41	91	17377	46641	79680279
NIH stroke scale abnormal	111.69	21.41	16	17452	9	79726911
Haemorrhagic stroke	103.91	21.41	50	17418	10996	79715924
Ventricular extrasystoles	102.32	21.41	60	17408	19644	79707276
Brain stem haemorrhage	98.55	21.41	29	17439	1621	79725299
Tongue oedema	97.94	21.41	42	17426	7075	79719845
Intracranial mass	93.66	21.41	30	17438	2229	79724691
Cerebral hyperperfusion syndrome	91.44	21.41	17	17451	115	79726805
Ventricular tachycardia	83.49	21.41	71	17397	41864	79685056
Cardiac arrest	83.01	21.41	141	17327	171955	79554965
Hemiplegia	81.57	21.41	47	17421	14892	79712028
Ischaemic stroke	80.50	21.41	63	17405	33068	79693852
Product quality issue	79.15	21.41	63	17405	33877	79693043
Diarrhoea	78.72	21.41	48	17420	880441	78846479
Cerebral artery occlusion	71.93	21.41	23	17445	1699	79725221
Haemothorax	71.03	21.41	31	17437	5447	79721473
Lip swelling	70.87	21.41	64	17404	40847	79686073
Gingival bleeding	67.68	21.41	43	17425	16233	79710687
Reperfusion arrhythmia	66.53	21.41	15	17453	285	79726635
Aortic dissection	65.33	21.41	27	17441	4148	79722772
Fatigue	64.98	21.41	65	17403	929662	78797258
Toxicity to various agents	64.98	21.41	8	17460	421532	79305388
Respiratory failure	61.93	21.41	128	17340	180783	79546137
Basal ganglia haemorrhage	60.39	21.41	20	17448	1651	79725269
Cardiogenic shock	58.16	21.41	58	17410	41856	79685064
Coma	54.60	21.41	87	17381	100562	79626358
Product closure issue	54.39	21.41	8	17460	7	79726913
Arthralgia	54.09	21.41	29	17439	571774	79155146
Hydrocephalus	53.98	21.41	30	17438	8870	79718050
Intracranial pressure increased	53.08	21.41	29	17439	8293	79718627
Intra-abdominal haemorrhage	50.25	21.41	23	17445	4517	79722403
Reperfusion injury	49.78	21.41	11	17457	190	79726730
Hypotension	48.66	21.41	208	17260	440109	79286811
Tongue haemorrhage	48.49	21.41	15	17453	994	79725926
Malaise	47.56	21.41	24	17444	489845	79237075
Cardiac tamponade	47.50	21.41	28	17440	9248	79717672
Mouth haemorrhage	45.82	21.41	29	17439	10870	79716050
Cytokine release syndrome	44.83	21.41	47	17421	35951	79690969
Nasopharyngitis	43.93	21.41	3	17465	253878	79473042
Heparin-induced thrombocytopenia	43.83	21.41	27	17441	9655	79717265
Epistaxis	43.05	21.41	83	17385	111432	79615488
Fall	42.87	21.41	27	17441	487602	79239318
Shock	42.42	21.41	50	17418	43498	79683422
Blood fibrinogen decreased	42.18	21.41	16	17452	1963	79724957
Myocardial rupture	41.93	21.41	10	17458	245	79726675
Catheter site haemorrhage	41.67	21.41	21	17447	5096	79721824
Anaphylactic reaction	40.83	21.41	69	17399	83674	79643246
Hemianopia	40.58	21.41	15	17453	1713	79725207
Treatment delayed	40.34	21.41	8	17460	79	79726841
Pulseless electrical activity	38.95	21.41	29	17439	14131	79712789
Pericardial haemorrhage	38.23	21.41	19	17449	4476	79722444
Brain death	36.81	21.41	20	17448	5657	79721263
Drug intolerance	36.15	21.41	7	17461	264112	79462808
Embolic stroke	35.87	21.41	22	17446	7804	79719116
Cerebral artery embolism	35.71	21.41	14	17454	1877	79725043
Extravasation	35.34	21.41	17	17451	3733	79723187
Weight decreased	35.06	21.41	17	17451	355181	79371739
Procedural haemorrhage	34.52	21.41	18	17450	4688	79722232
Coagulopathy	34.50	21.41	41	17427	35965	79690955
Pain	33.26	21.41	65	17403	703737	79023183
Bradycardia	33.13	21.41	84	17384	135473	79591447
Vitreous haemorrhage	32.49	21.41	16	17452	3697	79723223
Abdominal discomfort	31.57	21.41	8	17460	250719	79476201
Facial paralysis	30.79	21.41	30	17438	21042	79705878
Reocclusion	30.73	21.41	5	17463	13	79726907
Embolism	30.57	21.41	25	17443	13957	79712963
Paresis	30.41	21.41	16	17452	4245	79722675
Macular hole	30.37	21.41	10	17458	811	79726109
Intentional product use issue	29.90	21.41	87	17381	152025	79574895
Alopecia	29.88	21.41	7	17461	231348	79495572
Cerebellar haemorrhage	29.85	21.41	14	17454	2906	79724014
Weight increased	29.37	21.41	12	17456	277374	79449546
Product dose omission issue	29.12	21.41	9	17459	247528	79479392
Hypofibrinogenaemia	28.15	21.41	12	17456	1990	79724930
Dysarthria	28.15	21.41	52	17416	67570	79659350
Pruritus	28.13	21.41	27	17441	394621	79332299
Musculoskeletal stiffness	27.73	21.41	3	17465	175005	79551915
Myalgia	27.43	21.41	4	17464	185637	79541283
Cerebral artery thrombosis	27.40	21.41	10	17458	1101	79725819
Parotid gland haemorrhage	27.27	21.41	5	17463	31	79726889
Completed suicide	27.06	21.41	10	17458	245757	79481163
Retroperitoneal haemorrhage	26.67	21.41	16	17452	5454	79721466
Carotid artery occlusion	26.42	21.41	18	17450	7629	79719291
Cardiac ventricular thrombosis	26.17	21.41	11	17457	1762	79725158
Rash	25.95	21.41	55	17413	578303	79148617
Respiratory distress	25.73	21.41	46	17422	58293	79668627
Peripheral artery occlusion	25.34	21.41	12	17456	2545	79724375
Insomnia	25.32	21.41	11	17457	245159	79481761
Depression	25.28	21.41	8	17460	216782	79510138
Peripheral ischaemia	25.19	21.41	19	17449	9438	79717482
Electrocardiogram ST segment elevation	24.90	21.41	18	17450	8379	79718541
Decreased appetite	24.90	21.41	23	17445	342395	79384525
Intracardiac thrombus	24.75	21.41	14	17454	4279	79722641
Lip oedema	24.56	21.41	16	17452	6300	79720620
Retroperitoneal haematoma	24.56	21.41	15	17453	5282	79721638
Extrasystoles	24.54	21.41	17	17451	7402	79719518
Monoparesis	24.53	21.41	13	17455	3498	79723422
Cerebral ischaemia	24.44	21.41	20	17448	11175	79715745
Paralysis	23.57	21.41	21	17447	13156	79713764
Chest pain	23.53	21.41	123	17345	282181	79444739
Hypoxia	23.19	21.41	62	17406	103181	79623739
Cerebral artery stenosis	23.10	21.41	8	17460	757	79726163
Asthenia	22.66	21.41	49	17419	511640	79215280
Compartment syndrome	22.56	21.41	14	17454	5068	79721852
Factor I deficiency	22.28	21.41	3	17465	0	79726920
NIH stroke scale score decreased	22.28	21.41	3	17465	0	79726920
Quadriplegia	22.24	21.41	12	17456	3348	79723572
Haemoperitoneum	21.95	21.41	13	17455	4330	79722590
Multiple organ dysfunction syndrome	21.94	21.41	67	17401	120179	79606741
Thyroid haemorrhage	21.79	21.41	5	17463	103	79726817
Stridor	21.66	21.41	14	17454	5439	79721481
Cerebrovascular accident	21.64	21.41	79	17389	155213	79571707
Haematuria	21.54	21.41	47	17421	68789	79658131
Sinusitis	21.44	21.41	8	17460	195493	79531427

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B01AD02	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Enzymes
ATC	S01XA13	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D005343	Fibrinolytic Agents
MeSH PA	D006401	Hematologic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Acute myocardial infarction	indication	57054005	DOID:9408
Pulmonary embolism	indication	59282003	DOID:9477
Ischemic stroke	indication	422504002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Plasminogen	Enzyme	P00747	PLMN_HUMAN	ACTIVATOR				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
1RXS4UE564	UNII
4019319	VANDF
4019599	VANDF
C0032143	UMLSCUI
CHEMBL1201593	ChEMBL_ID
D02837	KEGG_DRUG
DB00009	DRUGBANK_ID
5975	INN_ID
204210	RXNORM
4155	MMSL
970	MMSL
d00521	MMSL
002074	NDDF
108997009	SNOMEDCT_US
27638005	SNOMEDCT_US
37411004	SNOMEDCT_US
387152000	SNOMEDCT_US
D010959	MESH_DESCRIPTOR_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Cathflo Activase	HUMAN PRESCRIPTION DRUG LABEL	1	50242-041	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	2.20 mg	INTRAVENOUS	BLA	21 sections
Cathflo Activase	HUMAN PRESCRIPTION DRUG LABEL	1	50242-041	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	2.20 mg	INTRAVENOUS	BLA	21 sections