heparin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
heparin derivatives including low molecular mass heparins 1358 9005-49-6

Description:

MoleculeDescription

Synonyms:

  • heparin
  • heparin sodium
  • heparin calcium
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
10 TU P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 9, 1939 FDA ORGANON USA INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heparin-induced thrombocytopenia 2299.17 11.38 563 44520 3402 50556639
Premature delivery 303.46 11.38 214 44869 23449 50536592
Shock haemorrhagic 229.74 11.38 123 44960 8221 50551820
Haemorrhage 216.01 11.38 252 44831 53189 50506852
Hereditary angioedema 210.64 11.38 101 44982 5341 50554700
Labelled drug-drug interaction medication error 201.06 11.38 122 44961 10355 50549686
Maternal exposure during pregnancy 189.76 11.38 431 44652 159347 50400694
Thrombocytopenia 182.10 11.38 371 44712 127302 50432739
Vascular stent thrombosis 182.08 11.38 56 45027 853 50559188
Exposure during pregnancy 170.61 11.38 350 44733 120665 50439376
Rheumatoid arthritis 161.56 11.38 4 45079 202546 50357495
Retroperitoneal haematoma 149.76 11.38 64 45019 2579 50557462
Cerebral haemorrhage 146.71 11.38 149 44934 26903 50533138
Pulmonary embolism 146.68 11.38 297 44786 101407 50458634
Retroperitoneal haemorrhage 145.18 11.38 62 45021 2494 50557547
Abdominal wall haematoma 144.99 11.38 63 45020 2645 50557396
Haematoma 142.20 11.38 155 44928 30355 50529686
Joint swelling 133.39 11.38 28 45055 245258 50314783
Haemorrhage intracranial 131.62 11.38 100 44983 12274 50547767
Drug intolerance 119.14 11.38 25 45058 219079 50340962
Arthropathy 115.95 11.38 6 45077 157900 50402141
Thrombosis in device 115.67 11.38 54 45029 2687 50557354
Arthralgia 114.13 11.38 134 44949 438568 50121473
Vascular pseudoaneurysm 110.98 11.38 43 45040 1341 50558700
Acute kidney injury 110.89 11.38 449 44634 227609 50332432
Extradural haematoma 108.70 11.38 44 45039 1543 50558498
Alopecia 99.45 11.38 47 45036 245000 50315041
Thrombosis 97.59 11.38 177 44906 55656 50504385
Multiple organ dysfunction syndrome 96.27 11.38 166 44917 50171 50509870
Completed suicide 93.79 11.38 6 45077 131883 50428158
Pemphigus 93.45 11.38 3 45080 120163 50439878
Product use in unapproved indication 93.21 11.38 270 44813 115549 50444492
Cerebral infarction 92.47 11.38 105 44978 21499 50538542
Premature baby 90.42 11.38 96 44987 18241 50541800
Haemoperitoneum 88.61 11.38 44 45039 2511 50557530
Activated partial thromboplastin time prolonged 82.26 11.38 58 45025 6344 50553697
Haematoma muscle 81.87 11.38 29 45054 699 50559342
Cardiogenic shock 81.08 11.38 84 44999 15515 50544526
Compartment syndrome 80.40 11.38 38 45045 1944 50558097
Spinal epidural haematoma 80.27 11.38 31 45052 958 50559083
Pain 78.39 11.38 260 44823 578643 49981398
Cardiac arrest 78.17 11.38 206 44877 83445 50476596
Haemothorax 77.63 11.38 37 45046 1929 50558112
Abdominal discomfort 76.28 11.38 57 45026 231584 50328457
Systemic lupus erythematosus 74.45 11.38 17 45066 140605 50419436
Pharyngeal haemorrhage 74.39 11.38 25 45058 512 50559529
Aplastic anaemia 70.56 11.38 57 45026 7646 50552395
Off label use 70.17 11.38 687 44396 473739 50086302
Toxic epidermal necrolysis 70.17 11.38 90 44993 20902 50539139
Foetal death 65.51 11.38 56 45027 8124 50551917
Low birth weight baby 63.58 11.38 48 45035 5833 50554208
Cardiac tamponade 63.03 11.38 42 45041 4190 50555851
Heparin-induced thrombocytopenia test positive 62.86 11.38 11 45072 4 50560037
Subdural haematoma 62.45 11.38 67 45016 12880 50547161
Hypotension 61.98 11.38 390 44693 235079 50324962
Subarachnoid haemorrhage 57.76 11.38 59 45024 10717 50549324
Infective aneurysm 56.96 11.38 19 45064 380 50559661
Disseminated intravascular coagulation 56.54 11.38 73 45010 17062 50542979
Embolism 56.41 11.38 48 45035 6920 50553121
Sepsis 56.17 11.38 251 44832 132674 50427367
Haemoglobin decreased 54.34 11.38 241 44842 126975 50433066
Wound 53.63 11.38 14 45069 105780 50454261
Hypersensitivity 52.35 11.38 69 45014 215092 50344949
Drug ineffective 52.02 11.38 474 44609 818859 49741182
Pericarditis 51.95 11.38 5 45078 78684 50481357
Coronary artery thrombosis 51.24 11.38 23 45060 1044 50558997
Respiratory failure 51.12 11.38 188 44895 90993 50469048
Peripheral ischaemia 50.94 11.38 37 45046 4239 50555802
Hypoxia 50.93 11.38 129 44954 50994 50509047
Coagulation time shortened 50.81 11.38 14 45069 141 50559900
Caesarean section 50.62 11.38 66 45017 15573 50544468
Acute motor-sensory axonal neuropathy 50.39 11.38 16 45067 272 50559769
Eosinophilia 50.22 11.38 72 45011 18580 50541461
Choroidal infarction 48.86 11.38 12 45071 73 50559968
Subchorionic haematoma 48.59 11.38 13 45070 116 50559925
Fatigue 48.12 11.38 402 44681 707199 49852842
Deep vein thrombosis 47.89 11.38 159 44924 73145 50486896
Treatment failure 46.39 11.38 33 45050 137604 50422437
Procedural haemorrhage 46.28 11.38 28 45055 2362 50557679
Coagulation time prolonged 46.17 11.38 22 45061 1146 50558895
Intracardiac thrombus 45.91 11.38 27 45056 2162 50557879
Encephalopathy 45.64 11.38 96 44987 33615 50526426
Weight increased 44.89 11.38 69 45014 201822 50358219
Gastrointestinal haemorrhage 44.35 11.38 155 44928 73166 50486875
Orbital compartment syndrome 44.35 11.38 9 45074 18 50560023
Adrenal haemorrhage 44.32 11.38 16 45067 408 50559633
Psoriasis 43.96 11.38 5 45078 68995 50491046
Skin necrosis 43.44 11.38 51 45032 10816 50549225
Muscle haemorrhage 43.20 11.38 29 45054 2929 50557112
Musculoskeletal stiffness 43.05 11.38 31 45052 128450 50431591
Arthritis 42.96 11.38 12 45071 86709 50473332
Rash 42.55 11.38 223 44860 437248 50122793
Nasopharyngitis 41.88 11.38 67 45016 192860 50367181
Pulmonary alveolar haemorrhage 41.62 11.38 32 45051 3995 50556046
Acute myocardial infarction 41.55 11.38 85 44998 29188 50530853
Swelling 41.53 11.38 72 45011 200800 50359241
Intentional overdose 41.18 11.38 4 45079 62500 50497541
Foetal exposure during pregnancy 40.69 11.38 81 45002 27278 50532763
Injection site pain 39.59 11.38 25 45058 110999 50449042
Coagulopathy 39.41 11.38 63 45020 17881 50542160
Blood pressure decreased 38.97 11.38 124 44959 55785 50504256
Lower respiratory tract infection 38.96 11.38 18 45065 95183 50464858
Anaemia 38.83 11.38 369 44714 252087 50307954
Cerebral haematoma 38.74 11.38 28 45055 3183 50556858
Platelet aggregation inhibition 38.72 11.38 11 45072 125 50559916
Pulmonary infarction 38.64 11.38 25 45058 2373 50557668
HELLP syndrome 38.45 11.38 18 45065 901 50559140
Ischaemic stroke 37.82 11.38 58 45025 15890 50544151
Gait disturbance 37.61 11.38 47 45036 149958 50410083
Cardiac valve replacement complication 37.44 11.38 11 45072 142 50559899
Brain herniation 37.39 11.38 27 45056 3065 50556976
Gangrene 37.32 11.38 32 45051 4660 50555381
Spinal cord compression 37.30 11.38 29 45054 3680 50556361
Rectosigmoid cancer 36.95 11.38 11 45072 149 50559892
Venous thrombosis 36.63 11.38 31 45052 4435 50555606
Toxoplasmosis 36.52 11.38 20 45063 1397 50558644
Drug abuse 36.51 11.38 5 45078 59841 50500200
Discomfort 36.50 11.38 26 45057 108354 50451687
Toxicity to various agents 36.37 11.38 85 44998 212414 50347627
Ocular retrobulbar haemorrhage 36.26 11.38 10 45073 101 50559940
Mobility decreased 36.15 11.38 13 45070 79935 50480106
Hepatic enzyme increased 35.54 11.38 42 45041 137338 50422703
Haemorrhagic transformation stroke 35.24 11.38 18 45065 1091 50558950
Platelet count decreased 35.12 11.38 180 44903 100546 50459495
Mixed liver injury 34.74 11.38 27 45056 3424 50556617
Thrombotic microangiopathy 34.72 11.38 41 45042 8750 50551291
Spinal subdural haematoma 34.63 11.38 10 45073 121 50559920
Electrocardiogram ST segment elevation 34.59 11.38 27 45056 3446 50556595
Aortic thrombosis 34.20 11.38 17 45066 972 50559069
Loss of personal independence in daily activities 34.13 11.38 10 45073 70040 50490001
Oesophageal intramural haematoma 34.08 11.38 9 45074 76 50559965
Splenic rupture 33.93 11.38 18 45065 1180 50558861
Rash maculo-papular 33.91 11.38 74 45009 26567 50533474
Hypercoagulation 33.63 11.38 21 45062 1874 50558167
Depression 33.54 11.38 60 45023 165363 50394678
Product dose omission issue 33.53 11.38 71 45012 183767 50376274
Hyperlactacidaemia 33.50 11.38 23 45060 2410 50557631
Stevens-Johnson syndrome 33.07 11.38 65 45018 21687 50538354
Suicidal ideation 32.92 11.38 5 45078 55380 50504661
Blood cholesterol increased 32.78 11.38 5 45078 55210 50504831
Malaise 32.60 11.38 171 44912 335361 50224680
Antiphospholipid syndrome 32.58 11.38 19 45064 1498 50558543
Vena cava thrombosis 32.39 11.38 21 45062 2000 50558041
Tonsillar haemorrhage 32.25 11.38 11 45072 236 50559805
Tachypnoea 31.77 11.38 51 45032 14526 50545515
Puncture site haemorrhage 31.49 11.38 11 45072 254 50559787
Paraplegia 30.99 11.38 22 45061 2432 50557609
Pericardial haemorrhage 30.62 11.38 18 45065 1440 50558601
Transcription medication error 30.60 11.38 10 45073 187 50559854
Contraindicated product administered 30.22 11.38 54 45029 148904 50411137
Product administration error 30.11 11.38 59 45024 19640 50540401
Suicide attempt 30 11.38 5 45078 51727 50508314
Incorrect drug administration rate 29.80 11.38 22 45061 2584 50557457
Irritable bowel syndrome 29.77 11.38 5 45078 51436 50508605
Septic shock 29.63 11.38 115 44968 57060 50502981
Therapeutic product effect incomplete 29.46 11.38 23 45060 91492 50468549
Shock 29.35 11.38 60 45023 20590 50539451
Insomnia 29.07 11.38 71 45012 174794 50385247
Intraventricular haemorrhage 28.92 11.38 19 45064 1851 50558190
Post procedural haemorrhage 28.86 11.38 34 45049 7236 50552805
Impaired healing 28.85 11.38 13 45070 69773 50490268
Oliguria 28.68 11.38 36 45047 8180 50551861
Embolic cerebral infarction 28.44 11.38 12 45071 468 50559573
Intracranial haematoma 28.36 11.38 11 45072 344 50559697
Catheter site haemorrhage 28.32 11.38 22 45061 2788 50557253
Drug chemical incompatibility 28.31 11.38 7 45076 44 50559997
Hypervolaemia 28.21 11.38 67 45016 25432 50534609
Ill-defined disorder 28.13 11.38 7 45076 54647 50505394
Premature rupture of membranes 28.11 11.38 27 45056 4553 50555488
Haemorrhagic infarction 27.70 11.38 10 45073 255 50559786
Arterial thrombosis 27.44 11.38 16 45067 1261 50558780
Respiratory distress 27.35 11.38 74 45009 30415 50529626
Anti factor Xa activity decreased 27.19 11.38 5 45078 4 50560037
Hemiparesis 27.02 11.38 57 45026 19991 50540050
Intra-abdominal haematoma 26.99 11.38 17 45066 1540 50558501
Memory impairment 26.76 11.38 19 45064 79341 50480700
Haemodynamic instability 26.18 11.38 34 45049 7990 50552051
Ventricular tachycardia 26.16 11.38 49 45034 15772 50544269
Peripheral artery thrombosis 25.81 11.38 17 45066 1663 50558378
Choroidal effusion 25.74 11.38 11 45072 443 50559598
Pulseless electrical activity 25.53 11.38 31 45052 6810 50553231
Vasodilatation 25.52 11.38 19 45064 2260 50557781
Peripheral swelling 25.37 11.38 96 44987 205840 50354201
Haemolysis 25.33 11.38 29 45054 5987 50554054
Atrial thrombosis 25.29 11.38 16 45067 1461 50558580
Cholestasis 25.19 11.38 64 45019 25337 50534704
Febrile neutropenia 25.15 11.38 161 44922 97506 50462535
Cerebellar haemorrhage 24.98 11.38 15 45068 1248 50558793
Acute generalised exanthematous pustulosis 24.79 11.38 35 45048 8903 50551138
Asthma 24.53 11.38 26 45057 89311 50470730
Arterial haemorrhage 24.52 11.38 16 45067 1541 50558500
Normal newborn 24.45 11.38 30 45053 6661 50553380
Cerebral amyloid angiopathy 24.36 11.38 8 45075 152 50559889
Injection site swelling 24.31 11.38 4 45079 41769 50518272
Abdominal compartment syndrome 23.79 11.38 11 45072 535 50559506
Lipoedema 23.74 11.38 9 45074 264 50559777
Osteoarthritis 23.70 11.38 16 45067 68590 50491451
Arterial intramural haematoma 23.46 11.38 5 45078 14 50560027
Foetal growth restriction 23.07 11.38 29 45054 6598 50553443
Spinal cord disorder 23.01 11.38 14 45069 1193 50558848
Product measured potency issue 22.86 11.38 7 45076 105 50559936
Renal vein thrombosis 22.83 11.38 9 45074 294 50559747
Haemorrhage subcutaneous 22.67 11.38 19 45064 2682 50557359
Pituitary apoplexy 22.27 11.38 7 45076 115 50559926
Intentional product misuse 22.17 11.38 7 45076 46727 50513314
Stress cardiomyopathy 22.05 11.38 31 45052 7856 50552185
Cerebral venous thrombosis 21.86 11.38 16 45067 1855 50558186
Acute respiratory distress syndrome 21.80 11.38 54 45029 21045 50538996
Ventricular fibrillation 21.73 11.38 36 45047 10523 50549518
Intra-abdominal haemorrhage 21.55 11.38 17 45066 2203 50557838
Paratonia 21.53 11.38 5 45078 23 50560018
Renal infarct 21.47 11.38 14 45069 1346 50558695
Vaginal haemorrhage 21.44 11.38 59 45024 24492 50535549
Cerebral reperfusion injury 21.33 11.38 4 45079 4 50560037
Therapeutic product effect decreased 21.25 11.38 57 45026 135993 50424048
Suspected transmission of an infectious agent via product 21.19 11.38 8 45075 232 50559809
Dizziness 21.11 11.38 202 44881 346167 50213874
Peritoneal haematoma 20.90 11.38 6 45077 71 50559970
Stillbirth 20.65 11.38 26 45057 5926 50554115
Postpartum haemorrhage 20.49 11.38 15 45068 1739 50558302
Product contamination 20.31 11.38 10 45073 560 50559481
Weight decreased 20.22 11.38 115 44968 221130 50338911
Acute respiratory failure 20.20 11.38 64 45019 28718 50531323
Confusional state 20.20 11.38 91 44992 185837 50374204
Coagulation time abnormal 20.17 11.38 6 45077 81 50559960
Subcapsular renal haematoma 20.16 11.38 8 45075 266 50559775
Gastrooesophageal reflux disease 20.15 11.38 23 45060 76405 50483636
Coronary artery perforation 20.14 11.38 5 45078 32 50560009
Vascular access site haemorrhage 20.06 11.38 4 45079 7 50560034
Haematuria 19.88 11.38 59 45024 25554 50534487
Protein C decreased 19.88 11.38 5 45078 34 50560007
Hepatic haematoma 19.80 11.38 9 45074 421 50559620
Drug reaction with eosinophilia and systemic symptoms 19.76 11.38 63 45020 28361 50531680
Splenic infarction 19.73 11.38 14 45069 1546 50558495
Atheroembolism 19.71 11.38 4 45079 8 50560033
Kidney rupture 19.63 11.38 5 45078 36 50560005
Blood pressure fluctuation 19.62 11.38 4 45079 35819 50524222
Myalgia 19.48 11.38 52 45031 124267 50435774
Feeling abnormal 19.28 11.38 53 45030 125439 50434602
Injection site erythema 19.27 11.38 23 45060 74913 50485128
Myelomalacia 19.17 11.38 5 45078 40 50560001
Organic brain syndrome 19.12 11.38 7 45076 186 50559855
Live birth 19.11 11.38 44 45039 16364 50543677
Haemoptysis 18.99 11.38 58 45025 25515 50534526
Calciphylaxis 18.99 11.38 17 45066 2621 50557420
Haemodialysis complication 18.77 11.38 7 45076 196 50559845
Cardiac failure 18.74 11.38 124 44959 75916 50484125
Inflammation 18.70 11.38 14 45069 56898 50503143
Platelet transfusion 18.67 11.38 10 45073 668 50559373
Gastrointestinal disorder 18.47 11.38 35 45048 94421 50465620
Pain in extremity 18.43 11.38 155 44928 272710 50287331
Premature labour 18.30 11.38 35 45048 11441 50548600
Device related infection 18.27 11.38 50 45033 20685 50539356
Blood albumin decreased 18.27 11.38 38 45045 13198 50546843
Bullous haemorrhagic dermatosis 18.09 11.38 5 45078 51 50559990
Cerebellar embolism 18.07 11.38 3 45080 0 50560041
Hand amputation 18.07 11.38 3 45080 0 50560041
Ureteric haemorrhage 18.07 11.38 3 45080 0 50560041
Phaeochromocytoma crisis 18.01 11.38 7 45076 220 50559821
Transfusion 17.75 11.38 37 45046 12868 50547173
Hemiplegia 17.72 11.38 27 45056 7354 50552687
Gestational hypertension 17.65 11.38 15 45068 2158 50557883
Injection site pruritus 17.55 11.38 7 45076 40404 50519637
Mucosal erosion 17.33 11.38 12 45071 1275 50558766
Arm amputation 17.29 11.38 4 45079 18 50560023
Ischaemic hepatitis 17.09 11.38 14 45069 1915 50558126
Product administered to patient of inappropriate age 17.08 11.38 16 45067 2614 50557427
Posthaemorrhagic hydrocephalus 16.95 11.38 4 45079 20 50560021
Procedural complication 16.62 11.38 21 45062 4802 50555239
Wrong technique in product usage process 16.57 11.38 15 45068 55495 50504546
Cholestatic liver injury 16.52 11.38 14 45069 2007 50558034
Injection site plaque 16.39 11.38 5 45078 74 50559967
Capillary fragility test 16.34 11.38 4 45079 24 50560017
Nervous system disorder 16.21 11.38 41 45042 16182 50543859
Anticoagulation drug level below therapeutic 16.13 11.38 9 45074 652 50559389
Hyperkalaemia 16.10 11.38 85 44998 48004 50512037
Aneurysm recanalisation 16.00 11.38 3 45080 3 50560038
Pre-eclampsia 15.99 11.38 27 45056 8017 50552024
COVID-19 15.98 11.38 83 45000 46579 50513462
Neurological symptom 15.87 11.38 20 45063 4562 50555479
Thrombolysis 15.80 11.38 5 45078 84 50559957
Dry gangrene 15.72 11.38 8 45075 481 50559560
Post procedural haematoma 15.55 11.38 11 45072 1209 50558832
Hepatic function abnormal 15.54 11.38 64 45019 32617 50527424
Cerebrovascular disorder 15.45 11.38 15 45068 2563 50557478
Renal failure 15.43 11.38 154 44929 106479 50453562
Herpes simplex hepatitis 15.43 11.38 7 45076 326 50559715
Patent ductus arteriosus 15.39 11.38 18 45065 3802 50556239
Protein S decreased 15.34 11.38 4 45079 32 50560009
Pseudomonas infection 15.34 11.38 29 45054 9401 50550640
Pelvic haematoma 15.23 11.38 8 45075 514 50559527
Hydrocephalus 15.17 11.38 20 45063 4768 50555273
Foetal exposure timing unspecified 15.16 11.38 6 45077 198 50559843
Folliculitis 15.16 11.38 8 45075 39217 50520824
Medical device site thrombosis 15.14 11.38 3 45080 5 50560036
Pulse absent 15.11 11.38 20 45063 4786 50555255
Recurrence of neuromuscular blockade 15.08 11.38 5 45078 98 50559943
Petechiae 15.07 11.38 34 45049 12478 50547563
Cerebral artery thrombosis 15.03 11.38 7 45076 346 50559695
Obstructive shock 15.02 11.38 4 45079 35 50560006
Medical device site haemorrhage 15.02 11.38 4 45079 35 50560006
Cerebral artery embolism 14.95 11.38 9 45074 752 50559289
Spinal cord haemorrhage 14.94 11.38 6 45077 206 50559835
Therapeutic product effect increased 14.93 11.38 10 45073 1006 50559035
Jugular vein thrombosis 14.88 11.38 15 45068 2681 50557360
Haemoglobin abnormal 14.87 11.38 19 45064 4393 50555648
Type 2 diabetes mellitus 14.85 11.38 6 45077 34369 50525672
Blood creatine increased 14.85 11.38 20 45063 4867 50555174
Heparin-induced thrombocytopenia test 14.78 11.38 3 45080 6 50560035
Vascular parkinsonism 14.72 11.38 5 45078 106 50559935
Spontaneous haematoma 14.68 11.38 9 45074 777 50559264
Infection 14.68 11.38 92 44991 172862 50387179
Threatened labour 14.67 11.38 9 45074 778 50559263
Plantar erythema 14.65 11.38 6 45077 217 50559824
Cytokine release syndrome 14.60 11.38 27 45056 8607 50551434
Agranulocytosis 14.45 11.38 47 45036 21374 50538667
Serratia infection 14.43 11.38 9 45074 801 50559240
Renal haemorrhage 14.42 11.38 9 45074 802 50559239
Electrocardiogram T wave alternans 14.37 11.38 4 45079 42 50559999
Peritonitis 14.30 11.38 38 45045 15448 50544593
International normalised ratio increased 14.26 11.38 76 45007 43076 50516965
Hepatic infarction 14.23 11.38 8 45075 588 50559453
Eosinophil cationic protein increased 14.20 11.38 4 45079 44 50559997
Diarrhoea 14.12 11.38 408 44675 588068 49971973
Adverse event 14.08 11.38 11 45072 43752 50516289
Spinal cord oedema 14.02 11.38 5 45078 123 50559918
Haemorrhagic cerebral infarction 13.99 11.38 8 45075 608 50559433
Balance disorder 13.94 11.38 26 45057 70564 50489477
Melaena 13.89 11.38 54 45029 26810 50533231
Fungal sepsis 13.78 11.38 10 45073 1144 50558897
Injury 13.70 11.38 14 45069 48911 50511130
Mouth ulceration 13.65 11.38 4 45079 28020 50532021
Anticoagulation drug level above therapeutic 13.64 11.38 10 45073 1162 50558879
Pulmonary artery thrombosis 13.62 11.38 8 45075 639 50559402
Breast cancer 13.52 11.38 11 45072 42879 50517162
Enterococcal infection 13.50 11.38 23 45060 6875 50553166
Thrombin time abnormal 13.46 11.38 3 45080 11 50560030
Tachycardia 13.45 11.38 142 44941 99621 50460420
Device related sepsis 13.38 11.38 16 45067 3459 50556582
Fistula discharge 13.21 11.38 9 45074 931 50559110
Stoma site haemorrhage 13.20 11.38 9 45074 932 50559109
Pulmonary haemorrhage 13.18 11.38 22 45061 6470 50553571
Eschar 13.16 11.38 7 45076 461 50559580
Adverse drug reaction 13.11 11.38 18 45065 55204 50504837
Rhinorrhoea 13.08 11.38 16 45067 51567 50508474
Cardiac ventricular thrombosis 12.91 11.38 7 45076 479 50559562
Subdural haemorrhage 12.86 11.38 14 45069 2735 50557306
Hypovolaemia 12.86 11.38 27 45056 9438 50550603
Pulmonary oedema 12.79 11.38 81 45002 48857 50511184
Coronary artery dissection 12.76 11.38 8 45075 719 50559322
Seizure like phenomena 12.72 11.38 9 45074 989 50559052
Cataract 12.72 11.38 14 45069 47286 50512755
Haematidrosis 12.71 11.38 4 45079 66 50559975
Dry mouth 12.66 11.38 19 45064 56159 50503882
Ventricular enlargement 12.65 11.38 4 45079 67 50559974
Leg amputation 12.60 11.38 12 45071 2001 50558040
Peritonitis bacterial 12.56 11.38 18 45065 4643 50555398
Blood creatinine increased 12.51 11.38 113 44970 76047 50483994
Arterial rupture 12.41 11.38 6 45077 323 50559718
Anxiety 12.38 11.38 100 44983 177506 50382535
Haemorrhagic stroke 12.37 11.38 19 45064 5209 50554832
Wound haematoma 12.33 11.38 4 45079 73 50559968
Sleep disorder 12.31 11.38 20 45063 57263 50502778
Abortion early 12.25 11.38 3 45080 18 50560023
Pulse waveform abnormal 12.18 11.38 4 45079 76 50559965
Ischaemia 12.17 11.38 17 45066 4280 50555761
Muscle spasms 12.15 11.38 64 45019 125489 50434552
Ankle brachial index decreased 12.13 11.38 4 45079 77 50559964
Basal ganglia haemorrhage 12.11 11.38 7 45076 543 50559498
Clostridium difficile colitis 12.04 11.38 39 45044 17703 50542338
Central venous catheterisation 12.03 11.38 12 45071 2118 50557923
Fall 12.03 11.38 218 44865 334714 50225327
Colorectal cancer 12.02 11.38 10 45073 1397 50558644
Blood loss anaemia 11.98 11.38 24 45059 8115 50551926
Adrenomegaly 11.98 11.38 3 45080 20 50560021
Limbal swelling 11.98 11.38 3 45080 20 50560021
Carotid intima-media thickness increased 11.94 11.38 4 45079 81 50559960
Procedural hypotension 11.92 11.38 9 45074 1093 50558948
Cytomegalovirus enterocolitis 11.89 11.38 7 45076 562 50559479
Adenocarcinoma of colon 11.88 11.38 12 45071 2150 50557891
Breast haematoma 11.85 11.38 5 45078 195 50559846
Toxic skin eruption 11.84 11.38 29 45054 11222 50548819
Splenic haemorrhage 11.83 11.38 5 45078 196 50559845
Gastrointestinal necrosis 11.75 11.38 13 45070 2585 50557456
Blister 11.73 11.38 38 45045 85380 50474661
Drug-device interaction 11.72 11.38 4 45079 86 50559955
Toxic encephalopathy 11.61 11.38 19 45064 5496 50554545
Epistaxis 11.61 11.38 97 44986 63857 50496184
Cerebral artery occlusion 11.53 11.38 8 45075 852 50559189
Atrial fibrillation 11.53 11.38 140 44943 101605 50458436
Renal artery thrombosis 11.47 11.38 4 45079 92 50559949
Bleeding time prolonged 11.47 11.38 7 45076 600 50559441
COVID-19 pneumonia 11.47 11.38 24 45059 8371 50551670
Acute pulmonary oedema 11.39 11.38 22 45061 7245 50552796

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heparin-induced thrombocytopenia 2894.06 12.30 792 44830 4187 29524718
Vascular stent thrombosis 336.38 12.30 133 45489 2477 29526428
Thrombocytopenia 248.58 12.30 603 45019 134220 29394685
Labelled drug-drug interaction medication error 217.14 12.30 167 45455 11992 29516913
Haematoma 206.55 12.30 215 45407 22997 29505908
Haemorrhage 175.89 12.30 277 45345 44795 29484110
Cardiogenic shock 162.25 12.30 173 45449 19017 29509888
Post procedural haemorrhage 151.79 12.30 111 45511 7380 29521525
Shock haemorrhagic 142.36 12.30 118 45504 9433 29519472
Haemorrhage intracranial 138.94 12.30 140 45482 14402 29514503
Cerebral haemorrhage 137.89 12.30 204 45418 31222 29497683
Multiple organ dysfunction syndrome 132.04 12.30 297 45325 62819 29466086
Thrombosis 129.99 12.30 236 45386 42809 29486096
Retroperitoneal haematoma 126.08 12.30 65 45557 2293 29526612
Thrombosis in device 124.02 12.30 71 45551 3093 29525812
Fatigue 118.32 12.30 192 45430 316629 29212276
Appendicolith 117.75 12.30 71 45551 3409 29525496
Coagulation time shortened 113.98 12.30 32 45590 187 29528718
Cardiac tamponade 113.21 12.30 77 45545 4558 29524347
Ventricular fibrillation 103.63 12.30 125 45497 15708 29513197
Heparin resistance 103.13 12.30 21 45601 16 29528889
Arterial thrombosis 96.01 12.30 46 45576 1382 29527523
Drug abuse 93.50 12.30 8 45614 79875 29449030
Septic shock 91.51 12.30 257 45365 62303 29466602
Activated partial thromboplastin time prolonged 89.91 12.30 83 45539 7659 29521246
Pulmonary embolism 89.00 12.30 290 45332 76244 29452661
Brain herniation 85.52 12.30 59 45563 3574 29525331
Appendicitis 84.73 12.30 85 45537 8694 29520211
Off label use 83.00 12.30 766 44856 300034 29228871
Arthralgia 82.88 12.30 57 45565 139560 29389345
Drug reaction with eosinophilia and systemic symptoms 82.60 12.30 152 45470 27840 29501065
Heparin-induced thrombocytopenia test positive 79.43 12.30 21 45601 94 29528811
Subarachnoid haemorrhage 75.99 12.30 84 45538 9608 29519297
Weight decreased 74.26 12.30 74 45548 150831 29378074
Depression 73.84 12.30 20 45602 85127 29443778
Toxicity to various agents 72.67 12.30 97 45525 173564 29355341
Eosinophilia 72.64 12.30 126 45496 22035 29506870
Coagulation time prolonged 72.42 12.30 36 45586 1174 29527731
Intraventricular haemorrhage 70.31 12.30 48 45574 2858 29526047
Retroperitoneal haemorrhage 69.06 12.30 45 45577 2478 29526427
Death 66.55 12.30 287 45335 341797 29187108
Coagulation time 65.71 12.30 12 45610 0 29528905
Low birth weight baby 63.80 12.30 64 45558 6544 29522361
Sepsis 63.06 12.30 406 45216 142276 29386629
Intra-abdominal haemorrhage 61.38 12.30 39 45583 2056 29526849
Disseminated intravascular coagulation 60.84 12.30 110 45512 19870 29509035
Cardiac arrest 60.51 12.30 277 45345 85314 29443591
Premature baby 60.26 12.30 101 45521 17179 29511726
Haematoma muscle 58.84 12.30 29 45593 928 29527977
Compartment syndrome 58.14 12.30 40 45582 2412 29526493
Muscle haemorrhage 57.43 12.30 45 45577 3317 29525588
Rash maculo-papular 57.22 12.30 120 45502 24169 29504736
Deep vein thrombosis 56.64 12.30 206 45416 57193 29471712
Product administration error 55.82 12.30 88 45534 14222 29514683
Haemoglobin decreased 55.20 12.30 320 45302 108055 29420850
Catheter site haemorrhage 54.77 12.30 36 45586 2012 29526893
Diarrhoea 54.29 12.30 297 45325 332401 29196504
Venous thrombosis 54.27 12.30 42 45580 3040 29525865
Fall 53.98 12.30 121 45501 177057 29351848
Acute kidney injury 52.03 12.30 631 44991 264636 29264269
Asthenia 51.27 12.30 166 45456 215084 29313821
Product use in unapproved indication 50.56 12.30 266 45356 86609 29442296
Hypotension 50.43 12.30 489 45133 193865 29335040
Haemodynamic instability 50.00 12.30 62 45560 8011 29520894
Pericardial haemorrhage 49.57 12.30 39 45583 2892 29526013
Procedural haemorrhage 48.91 12.30 35 45587 2248 29526657
Intentional overdose 47.51 12.30 3 45619 38525 29490380
Coagulation time abnormal 47.23 12.30 15 45607 141 29528764
Pharyngeal haemorrhage 46.35 12.30 22 45600 647 29528258
Haemothorax 46.16 12.30 40 45582 3396 29525509
Coagulation test abnormal 45.92 12.30 20 45602 479 29528426
Acute respiratory distress syndrome 45.75 12.30 106 45516 22829 29506076
Cardiac ventricular thrombosis 44.83 12.30 24 45598 915 29527990
Pulmonary haemorrhage 44.75 12.30 63 45559 9207 29519698
Ventricular tachycardia 44.66 12.30 104 45518 22470 29506435
Decreased appetite 44.45 12.30 99 45523 145243 29383662
Insomnia 44.22 12.30 43 45579 88718 29440187
Pulseless electrical activity 44.07 12.30 52 45570 6382 29522523
Cerebral infarction 42.75 12.30 108 45514 24567 29504338
Lymphocyte count decreased 41.70 12.30 92 45530 19179 29509726
Product measured potency issue 41.65 12.30 12 45610 78 29528827
Dizziness 41.27 12.30 152 45470 189532 29339373
Skin necrosis 40.26 12.30 44 45578 4968 29523937
Incision site pain 39.73 12.30 28 45594 1755 29527150
Pain 39.54 12.30 134 45488 171298 29357607
Kounis syndrome 39.09 12.30 28 45594 1801 29527104
Coronary artery thrombosis 39.01 12.30 29 45593 1976 29526929
Hypertransaminasaemia 38.68 12.30 37 45585 3569 29525336
Weight increased 38.35 12.30 37 45585 76630 29452275
Product dose omission issue 38.09 12.30 56 45566 96327 29432578
Hereditary angioedema 37.89 12.30 20 45602 741 29528164
Peripheral artery thrombosis 37.54 12.30 29 45593 2093 29526812
Malaise 37.32 12.30 124 45498 159478 29369427
Choroidal infarction 36.76 12.30 11 45611 83 29528822
Suspected product quality issue 36.18 12.30 12 45610 131 29528774
Adrenal haemorrhage 36.01 12.30 13 45609 186 29528719
Coagulopathy 35.97 12.30 83 45539 17824 29511081
Psoriasis 35.66 12.30 4 45618 32223 29496682
Therapeutic product effect decreased 35.45 12.30 113 45509 29338 29499567
Muscle spasms 35.44 12.30 29 45593 65053 29463852
Product quality issue 34.52 12.30 76 45546 15819 29513086
Respiratory failure 34.38 12.30 262 45360 96869 29432036
Musculoskeletal stiffness 33.99 12.30 8 45614 37450 29491455
Aggression 33.44 12.30 7 45615 35534 29493371
Cerebral venous sinus thrombosis 33.41 12.30 15 45607 387 29528518
Pulmonary alveolar haemorrhage 33.26 12.30 45 45577 6335 29522570
Intestinal ischaemia 33.07 12.30 46 45576 6646 29522259
Gait disturbance 32.67 12.30 39 45583 73310 29455595
Haemorrhagic infarction 32.44 12.30 15 45607 415 29528490
Pulmonary haematoma 32.44 12.30 9 45613 50 29528855
Myalgia 32.29 12.30 40 45582 73979 29454926
Red blood cells urine positive 32.11 12.30 24 45598 1649 29527256
Haematuria 32.01 12.30 144 45478 43995 29484910
Puncture site haemorrhage 31.65 12.30 13 45609 268 29528637
Intracardiac thrombus 31.40 12.30 27 45595 2268 29526637
Aortic thrombosis 31.38 12.30 17 45605 664 29528241
Asthma 31.17 12.30 7 45615 33842 29495063
Vascular stent occlusion 31.08 12.30 11 45611 148 29528757
Memory impairment 30.79 12.30 9 45613 36461 29492444
Heparin-induced thrombocytopenia test 30.58 12.30 10 45612 104 29528801
Dehydration 30.49 12.30 84 45538 114664 29414241
Atrial thrombosis 30.47 12.30 25 45597 1968 29526937
Burkholderia test positive 30.27 12.30 19 45603 980 29527925
Renal infarct 30.12 12.30 20 45602 1137 29527768
Arterial haemorrhage 29.97 12.30 17 45605 727 29528178
Vasodilatation 29.84 12.30 19 45603 1005 29527900
Cerebral reperfusion injury 29.80 12.30 6 45616 4 29528901
Stress 29.16 12.30 86 45536 21404 29507501
Embolism 29.12 12.30 44 45578 6852 29522053
Reperfusion injury 29.09 12.30 9 45613 77 29528828
Cerebral hyperperfusion syndrome 28.99 12.30 9 45613 78 29528827
Balance disorder 28.63 12.30 10 45612 36160 29492745
Brain oedema 28.34 12.30 60 45562 12160 29516745
Drug intolerance 28.33 12.30 20 45602 48359 29480546
Coronary artery perforation 28.04 12.30 8 45614 50 29528855
Chest wall haematoma 27.70 12.30 10 45612 143 29528762
Cardiac procedure complication 27.33 12.30 10 45612 149 29528756
Product contamination 27.27 12.30 15 45607 604 29528301
Electrocardiogram ST segment elevation 27.02 12.30 34 45588 4458 29524447
Device related thrombosis 26.50 12.30 17 45605 911 29527994
Tongue haematoma 26.07 12.30 9 45613 112 29528793
Peripheral artery occlusion 25.91 12.30 20 45602 1442 29527463
Anticoagulation drug level below therapeutic 25.85 12.30 15 45607 670 29528235
Spinal epidural haematoma 25.83 12.30 11 45611 249 29528656
Haemorrhagic transformation stroke 25.65 12.30 19 45603 1287 29527618
Neuropathy peripheral 25.47 12.30 44 45578 70983 29457922
Blood urea increased 25.30 12.30 98 45524 28014 29500891
Prosthetic cardiac valve thrombosis 25.08 12.30 6 45616 16 29528889
Ischaemic hepatitis 24.90 12.30 20 45602 1528 29527377
Aneurysm ruptured 24.89 12.30 13 45609 471 29528434
Somnolence 24.79 12.30 69 45553 93886 29435019
Aortic dissection 24.70 12.30 24 45598 2360 29526545
Acute myocardial infarction 24.59 12.30 143 45479 48295 29480610
Acute respiratory failure 24.55 12.30 93 45529 26309 29502596
Haemoperitoneum 24.52 12.30 20 45602 1562 29527343
Jugular vein thrombosis 24.48 12.30 19 45603 1381 29527524
Injection site pain 23.96 12.30 10 45612 32436 29496469
Leukocytosis 23.53 12.30 79 45543 21063 29507842
Agitation 23.14 12.30 27 45595 51277 29477628
Arthropathy 23.04 12.30 3 45619 21551 29507354
Gastrointestinal haemorrhage 23.00 12.30 205 45417 79328 29449577
Subdural haematoma 22.99 12.30 71 45551 18122 29510783
Abdominal discomfort 22.93 12.30 24 45598 47879 29481026
Vascular pseudoaneurysm 22.83 12.30 21 45601 1928 29526977
Embolic stroke 22.82 12.30 28 45594 3578 29525327
Vena cava thrombosis 22.71 12.30 16 45606 1002 29527903
Cerebral mass effect 22.38 12.30 15 45607 866 29528039
Pain in extremity 22.37 12.30 91 45531 110342 29418563
Acute right ventricular failure 22.25 12.30 8 45614 113 29528792
Haemorrhagic cerebral infarction 22.19 12.30 14 45608 729 29528176
Feeling abnormal 22.12 12.30 31 45591 54414 29474491
Rash morbilliform 21.99 12.30 23 45599 2470 29526435
Suspected transmission of an infectious agent via product 21.82 12.30 13 45609 610 29528295
Hypercoagulation 21.70 12.30 16 45606 1076 29527829
Gastrointestinal necrosis 21.65 12.30 25 45597 2997 29525908
Dyspnoea exertional 21.47 12.30 15 45607 36475 29492430
Haemorrhagic stroke 21.45 12.30 35 45587 5821 29523084
Rash 21.19 12.30 189 45433 189630 29339275
Antiphospholipid syndrome 20.95 12.30 11 45611 403 29528502
Peripheral ischaemia 20.68 12.30 32 45590 5087 29523818
Incorrect drug administration rate 20.65 12.30 16 45606 1160 29527745
Activated partial thromboplastin time shortened 20.53 12.30 11 45611 420 29528485
Dyspnoea 20.48 12.30 368 45254 326364 29202541
Foetal growth restriction 20.30 12.30 27 45595 3739 29525166
Dysgeusia 20.26 12.30 5 45617 22669 29506236
Foetal exposure timing unspecified 20.23 12.30 9 45613 227 29528678
Loss of personal independence in daily activities 20.19 12.30 7 45615 25433 29503472
Drug hypersensitivity 20.13 12.30 177 45445 68229 29460676
Mixed liver injury 20.05 12.30 20 45602 2031 29526874
Overdose 20.04 12.30 60 45562 79759 29449146
Neutrophil count increased 20.00 12.30 59 45563 14683 29514222
Peripheral swelling 19.79 12.30 43 45579 63696 29465209
Unresponsive to stimuli 19.75 12.30 84 45538 25042 29503863
Livedo reticularis 19.75 12.30 20 45602 2068 29526837
Hemiplegia 19.68 12.30 36 45586 6558 29522347
Respiratory tract oedema 19.68 12.30 10 45612 342 29528563
Arthritis 19.66 12.30 7 45615 25012 29503893
Alopecia 19.60 12.30 3 45619 19081 29509824
Herpes zoster 19.55 12.30 11 45611 30041 29498864
Toxic epidermal necrolysis 19.47 12.30 67 45555 18086 29510819
Anxiety 19.46 12.30 67 45555 85298 29443607
Oedema peripheral 19.33 12.30 88 45534 103469 29425436
Peliosis hepatis 19.32 12.30 6 45616 52 29528853
Extradural haematoma 19.32 12.30 15 45607 1091 29527814
Graft thrombosis 19.24 12.30 9 45613 256 29528649
Psychotic disorder 19.17 12.30 4 45618 20350 29508555
Mediastinal haematoma 19.15 12.30 7 45615 104 29528801
Epistaxis 19.14 12.30 141 45481 51563 29477342
Sleep disorder 18.86 12.30 7 45615 24379 29504526
Intrapericardial thrombosis 18.84 12.30 6 45616 57 29528848
Shock 18.76 12.30 74 45548 21330 29507575
Nasopharyngitis 18.74 12.30 40 45582 59625 29469280
Vascular access site haematoma 18.67 12.30 4 45618 5 29528900
Medical device site thrombosis 18.30 12.30 5 45617 26 29528879
Bronchial haemorrhage 18.25 12.30 12 45610 671 29528234
Osteoarthritis 18.24 12.30 3 45619 18100 29510805
Anticoagulation drug level above therapeutic 18.16 12.30 18 45604 1813 29527092
Haemoptysis 18.05 12.30 94 45528 30456 29498449
Ischaemic stroke 18.04 12.30 60 45562 15917 29512988
Hypoxia 17.99 12.30 130 45492 47249 29481656
Cognitive disorder 17.75 12.30 7 45615 23492 29505413
Gastric haemorrhage 17.48 12.30 42 45580 9255 29519650
Subcutaneous haematoma 17.42 12.30 13 45609 891 29528014
Therapeutic product ineffective 17.39 12.30 11 45611 575 29528330
Vertigo 17.37 12.30 6 45616 21855 29507050
Diabetes insipidus 17.21 12.30 20 45602 2414 29526491
Thrombotic microangiopathy 17.17 12.30 40 45582 8641 29520264
Pancreatic haemorrhage 17.16 12.30 5 45617 34 29528871
Protein urine present 17.11 12.30 28 45594 4666 29524239
Prostate cancer 17.10 12.30 9 45613 25518 29503387
Pulmonary artery thrombosis 16.91 12.30 11 45611 604 29528301
Abdominal distension 16.87 12.30 125 45497 45786 29483119
Malignant neoplasm progression 16.81 12.30 58 45564 73801 29455104
Mean cell haemoglobin concentration 16.80 12.30 5 45617 37 29528868
Platelet disorder 16.65 12.30 15 45607 1340 29527565
Vascular access site haemorrhage 16.63 12.30 4 45618 11 29528894
Visual impairment 16.46 12.30 13 45609 29695 29499210
Anisochromia 16.43 12.30 3 45619 0 29528905
Acquired antithrombin III deficiency 16.43 12.30 3 45619 0 29528905
Procedural pain 16.41 12.30 26 45596 4218 29524687
Ventricular asystole 16.33 12.30 7 45615 161 29528744
Irritability 16.08 12.30 7 45615 22145 29506760
Dermatitis bullous 16.08 12.30 31 45591 5875 29523030
Blood loss anaemia 16.07 12.30 35 45587 7231 29521674
Cough 16.03 12.30 122 45500 126605 29402300
Blood pressure decreased 15.69 12.30 122 45500 45355 29483550
Neonatal respiratory distress syndrome 15.65 12.30 24 45598 3786 29525119
Treatment noncompliance 15.57 12.30 9 45613 24218 29504687
Urea renal clearance decreased 15.49 12.30 4 45618 16 29528889
Head injury 15.47 12.30 3 45619 16078 29512827
Hypovolaemic shock 15.47 12.30 31 45591 6041 29522864
Renal haemorrhage 15.44 12.30 14 45608 1262 29527643
Nutritional condition abnormal 15.33 12.30 9 45613 411 29528494
Tachycardia 15.31 12.30 175 45447 72235 29456670
Rhinorrhoea 15.31 12.30 7 45615 21512 29507393
Confusional state 15.29 12.30 125 45497 127752 29401153
Gangrene 15.16 12.30 25 45597 4193 29524712
Melaena 15.15 12.30 91 45531 31085 29497820
Respiratory distress 15.15 12.30 93 45529 32013 29496892
Ventricular extrasystoles 14.98 12.30 43 45579 10539 29518366
Hepatic infarction 14.96 12.30 7 45615 199 29528706
Cerebral haematoma 14.82 12.30 25 45597 4271 29524634
COVID-19 pneumonia 14.77 12.30 40 45582 9482 29519423
Alveolitis necrotising 14.77 12.30 4 45618 20 29528885
Retinal pigment epitheliopathy 14.71 12.30 7 45615 207 29528698
Basal cell carcinoma 14.59 12.30 4 45618 16906 29511999
Splenic infarction 14.52 12.30 16 45606 1823 29527082
Bronchopulmonary aspergillosis 14.52 12.30 47 45575 12297 29516608
Myiasis 14.45 12.30 4 45618 22 29528883
Reperfusion arrhythmia 14.36 12.30 5 45617 64 29528841
Autoimmune heparin-induced thrombocytopenia 14.35 12.30 3 45619 3 29528902
Bullous haemorrhagic dermatosis 14.35 12.30 3 45619 3 29528902
Intra-abdominal haematoma 14.34 12.30 13 45609 1171 29527734
Distributive shock 14.32 12.30 12 45610 973 29527932
Vision blurred 14.29 12.30 25 45597 40151 29488754
Fungal sepsis 14.19 12.30 11 45611 798 29528107
Haemorrhagic cholecystitis 14.08 12.30 5 45617 68 29528837
Upper gastrointestinal haemorrhage 14.05 12.30 69 45553 21845 29507060
Monoplegia 13.97 12.30 14 45608 1429 29527476
Hot flush 13.84 12.30 3 45619 14867 29514038
Gastrooesophageal reflux disease 13.75 12.30 17 45605 31479 29497426
Wrong technique in product usage process 13.68 12.30 17 45605 31411 29497494
Microangiopathic haemolytic anaemia 13.65 12.30 11 45611 844 29528061
Complications of transplanted kidney 13.63 12.30 23 45599 3931 29524974
Inferior vena caval occlusion 13.63 12.30 4 45618 28 29528877
Necrotising oesophagitis 13.53 12.30 9 45613 513 29528392
Coronary artery aneurysm 13.45 12.30 5 45617 78 29528827
Encephalopathy 13.45 12.30 88 45534 30955 29497950
Tremor 13.42 12.30 63 45559 73475 29455430
Full blood count decreased 13.40 12.30 4 45618 15988 29512917
Primary adrenal insufficiency 13.39 12.30 4 45618 30 29528875
Apgar score abnormal 13.39 12.30 4 45618 30 29528875
Blood pressure fluctuation 13.35 12.30 7 45615 19887 29509018
Catheter site haematoma 13.32 12.30 6 45616 156 29528749
Influenza 13.21 12.30 28 45594 41853 29487052
Vascular graft thrombosis 13.18 12.30 6 45616 160 29528745
Microstomia 13.14 12.30 3 45619 6 29528899
Paraesthesia 13.14 12.30 41 45581 53804 29475101
Aplastic anaemia 13.13 12.30 33 45589 7477 29521428
Basophil count decreased 13.06 12.30 5 45617 85 29528820
Platelet transfusion 13.04 12.30 12 45610 1102 29527803
Syncope 12.99 12.30 73 45549 81298 29447607
Soft tissue necrosis 12.93 12.30 7 45615 273 29528632
Cytokine release syndrome 12.85 12.30 47 45575 13072 29515833
Road traffic accident 12.84 12.30 4 45618 15557 29513348
Disease progression 12.80 12.30 74 45548 81842 29447063
White blood cell count decreased 12.65 12.30 76 45546 83286 29445619
Hemiparesis 12.62 12.30 50 45572 14436 29514469
Renal artery thrombosis 12.59 12.30 7 45615 288 29528617
Lumbar puncture 12.55 12.30 5 45617 95 29528810
Incision site haematoma 12.55 12.30 5 45617 95 29528810
Anti factor Xa activity decreased 12.54 12.30 3 45619 8 29528897
Torsade de pointes 12.42 12.30 30 45592 6631 29522274
Orthostatic hypotension 12.41 12.30 10 45612 22619 29506286
Hallucination 12.41 12.30 32 45590 44680 29484225
Respiratory gas exchange disorder 12.40 12.30 8 45614 433 29528472
Alanine aminotransferase decreased 12.36 12.30 10 45612 772 29528133
Osteonecrosis of jaw 12.33 12.30 5 45617 16505 29512400
Haemobilia 12.31 12.30 7 45615 301 29528604

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heparin-induced thrombocytopenia 5007.80 10.96 1308 79562 7171 64410691
Vascular stent thrombosis 507.59 10.96 182 80688 3182 64414680
Thrombocytopenia 462.77 10.96 926 79944 222875 64194987
Labelled drug-drug interaction medication error 382.34 10.96 274 80596 21788 64396074
Haemorrhage 352.33 10.96 465 80405 78886 64338976
Shock haemorrhagic 348.46 10.96 233 80637 16558 64401304
Haematoma 318.07 10.96 339 80531 45911 64371951
Cerebral haemorrhage 267.29 10.96 325 80545 50765 64367097
Retroperitoneal haematoma 262.52 10.96 125 80745 4586 64413276
Completed suicide 252.76 10.96 6 80864 224408 64193454
Cardiogenic shock 252.30 10.96 254 80616 32173 64385689
Haemorrhage intracranial 250.90 10.96 221 80649 23663 64394199
Thrombosis 240.91 10.96 365 80505 70277 64347585
Pulmonary embolism 240.27 10.96 552 80318 145804 64272058
Premature delivery 236.36 10.96 192 80678 18397 64399465
Multiple organ dysfunction syndrome 235.21 10.96 441 80429 100972 64316890
Thrombosis in device 218.60 10.96 113 80757 4958 64412904
Retroperitoneal haemorrhage 217.14 10.96 111 80759 4757 64413105
Arthralgia 216.06 10.96 145 80725 442115 63975747
Fatigue 188.37 10.96 413 80457 748317 63669545
Joint swelling 188.33 10.96 24 80846 215358 64202504
Rheumatoid arthritis 179.03 10.96 6 80864 164288 64253574
Activated partial thromboplastin time prolonged 174.77 10.96 138 80732 12693 64405169
Pain 171.18 10.96 269 80601 553242 63864620
Cardiac tamponade 168.67 10.96 113 80757 8051 64409811
Post procedural haemorrhage 167.82 10.96 133 80737 12298 64405564
Acute kidney injury 166.79 10.96 1047 79823 448193 63969669
Drug intolerance 146.21 10.96 29 80841 187963 64229899
Coagulation time shortened 145.96 10.96 42 80828 344 64417518
Maternal exposure during pregnancy 144.56 10.96 350 80520 95534 64322328
Cerebral infarction 144.03 10.96 215 80655 40829 64377033
Haemothorax 137.57 10.96 82 80788 4760 64413102
Cardiac arrest 137.12 10.96 465 80405 153599 64264263
Sepsis 137.05 10.96 612 80258 229729 64188133
Off label use 132.45 10.96 1291 79579 631515 63786347
Appendicolith 131.65 10.96 71 80799 3398 64414464
Haematoma muscle 129.55 10.96 57 80813 1736 64416126
Brain herniation 126.80 10.96 87 80783 6446 64411416
Ventricular fibrillation 126.71 10.96 153 80717 23707 64394155
Septic shock 126.20 10.96 353 80517 105084 64312778
Abdominal wall haematoma 125.17 10.96 74 80796 4231 64413631
Heparin-induced thrombocytopenia test positive 124.84 10.96 30 80840 108 64417754
Compartment syndrome 123.71 10.96 73 80797 4159 64413703
Exposure during pregnancy 122.96 10.96 289 80581 77386 64340476
Drug abuse 122.60 10.96 12 80858 132362 64285500
Deep vein thrombosis 120.87 10.96 347 80523 104835 64313027
Arthropathy 120.26 10.96 8 80862 120959 64296903
Arterial thrombosis 118.91 10.96 59 80811 2371 64415491
Subarachnoid haemorrhage 117.69 10.96 130 80740 18308 64399554
Eosinophilia 117.55 10.96 188 80682 37888 64379974
Haemoglobin decreased 117.29 10.96 520 80350 194543 64223319
Heparin resistance 116.34 10.96 23 80847 20 64417842
Product use in unapproved indication 116.31 10.96 484 80386 176134 64241728
Alopecia 116.08 10.96 32 80838 165658 64252204
Vascular pseudoaneurysm 115.94 10.96 63 80807 3061 64414801
Toxicity to various agents 114.72 10.96 174 80696 363339 64054523
Coagulation time prolonged 113.67 10.96 55 80815 2091 64415771
Pharyngeal haemorrhage 112.77 10.96 46 80824 1156 64416706
Disseminated intravascular coagulation 111.42 10.96 168 80702 32180 64385682
Muscle haemorrhage 105.52 10.96 74 80796 5679 64412183
Extradural haematoma 105.00 10.96 56 80814 2620 64415242
Haemoperitoneum 100.17 10.96 62 80808 3853 64414009
Respiratory failure 98.61 10.96 432 80438 160751 64257111
Hereditary angioedema 98.20 10.96 61 80809 3815 64414047
Spinal epidural haematoma 97.95 10.96 42 80828 1200 64416662
Drug reaction with eosinophilia and systemic symptoms 97.24 10.96 212 80658 54005 64363857
Procedural haemorrhage 95.47 10.96 62 80808 4190 64413672
Venous thrombosis 92.03 10.96 71 80799 6310 64411552
Hypotension 91.39 10.96 801 80069 380173 64037689
Abdominal discomfort 91.23 10.96 58 80812 182264 64235598
Nasopharyngitis 89.37 10.96 69 80801 196004 64221858
Weight increased 88.76 10.96 82 80788 213266 64204596
Malaise 88.59 10.96 232 80638 396015 64021847
Rash maculo-papular 87.90 10.96 187 80683 46839 64371023
Coronary artery thrombosis 87.85 10.96 51 80819 2818 64415044
Intentional overdose 86.39 10.96 7 80863 89937 64327925
Catheter site haemorrhage 84.08 10.96 59 80811 4532 64413330
Choroidal infarction 83.21 10.96 23 80847 160 64417702
Dizziness 82.28 10.96 271 80599 429892 63987970
Intraventricular haemorrhage 82.24 10.96 56 80814 4097 64413765
Intracardiac thrombus 82.13 10.96 54 80816 3727 64414135
Appendicitis 82.02 10.96 93 80777 13476 64404386
Product administration error 81.93 10.96 134 80736 27509 64390353
Weight decreased 80.59 10.96 147 80723 285592 64132270
Depression 80.40 10.96 67 80803 183224 64234638
Pericardial haemorrhage 80.08 10.96 55 80815 4081 64413781
Skin necrosis 79.55 10.96 94 80776 14235 64403627
Fall 78.07 10.96 265 80605 416561 64001301
Intra-abdominal haemorrhage 76.62 10.96 53 80817 3978 64413884
Adrenal haemorrhage 75.72 10.96 28 80842 536 64417326
Toxic epidermal necrolysis 75.56 10.96 153 80717 37013 64380849
Coagulopathy 75.39 10.96 140 80730 31780 64386082
Peripheral artery thrombosis 75.25 10.96 47 80823 2968 64414894
Subdural haematoma 75.17 10.96 130 80740 27924 64389938
Embolism 74.20 10.96 84 80786 12151 64405711
Pulmonary alveolar haemorrhage 73.38 10.96 75 80795 9663 64408199
Acute myocardial infarction 71.50 10.96 221 80649 69497 64348365
Coagulation time 71.18 10.96 13 80857 3 64417859
Musculoskeletal stiffness 70.63 10.96 33 80837 123173 64294689
Aplastic anaemia 70.24 10.96 87 80783 13833 64404029
Gait disturbance 69.44 10.96 68 80802 172087 64245775
Injection site pain 68.39 10.96 27 80843 111381 64306481
Peripheral ischaemia 67.67 10.96 67 80803 8311 64409551
Diarrhoea 67.13 10.96 582 80288 722122 63695740
Arthritis 67.10 10.96 12 80858 83802 64334060
Haemodynamic instability 67.04 10.96 88 80782 14824 64403038
Insomnia 66.96 10.96 90 80780 197746 64220116
Pulseless electrical activity 66.51 10.96 81 80789 12658 64405204
Psoriasis 65.08 10.96 7 80863 71696 64346166
Acute respiratory distress syndrome 65.03 10.96 148 80722 38787 64379075
Suicidal ideation 64.40 10.96 5 80865 66537 64351325
Suicide attempt 64.27 10.96 7 80863 71000 64346862
Gastrointestinal haemorrhage 63.71 10.96 331 80539 131981 64285881
Pemphigus 63.44 10.96 3 80867 60698 64357164
Haematuria 63.23 10.96 193 80677 60278 64357584
Product dose omission issue 61.55 10.96 93 80777 194654 64223208
Haemorrhagic transformation stroke 61.54 10.96 38 80832 2351 64415511
Hypoxia 61.46 10.96 246 80624 87903 64329959
Coagulation time abnormal 61.11 10.96 19 80851 208 64417654
Aortic thrombosis 60.30 10.96 32 80838 1482 64416380
Lower respiratory tract infection 59.62 10.96 22 80848 94592 64323270
Cardiac ventricular thrombosis 59.36 10.96 31 80839 1389 64416473
Asthenia 59.10 10.96 306 80564 427738 63990124
Asthma 58.57 10.96 23 80847 95202 64322660
Wound 56.95 10.96 13 80857 76464 64341398
Ventricular tachycardia 56.95 10.96 130 80740 34135 64383727
Peripheral swelling 56.82 10.96 110 80760 209043 64208819
Haemorrhagic infarction 56.12 10.96 24 80846 681 64417181
Pain in extremity 55.12 10.96 195 80675 302890 64114972
Product measured potency issue 54.68 10.96 17 80853 186 64417676
Rash 54.59 10.96 344 80526 458205 63959657
Encephalopathy 54.43 10.96 180 80690 58639 64359223
Systemic lupus erythematosus 54.31 10.96 15 80855 77597 64340265
Vasodilatation 53.45 10.96 38 80832 2980 64414882
Headache 52.41 10.96 419 80451 529048 63888814
Memory impairment 52.20 10.96 21 80849 85661 64332201
Cerebral haematoma 51.72 10.96 54 80816 7131 64410731
Arterial haemorrhage 51.24 10.96 33 80837 2198 64415664
Puncture site haemorrhage 51.14 10.96 21 80849 537 64417325
Blood pressure decreased 51.12 10.96 229 80641 85970 64331892
Pulmonary haemorrhage 50.81 10.96 72 80798 13037 64404825
Vena cava thrombosis 50.04 10.96 34 80836 2478 64415384
Myalgia 49.86 10.96 76 80794 158541 64259321
Feeling abnormal 49.14 10.96 57 80813 133545 64284317
Coronary artery perforation 48.97 10.96 13 80857 76 64417786
Renal infarct 48.91 10.96 33 80837 2378 64415484
Hypercoagulation 48.71 10.96 34 80836 2589 64415273
Atrial thrombosis 48.63 10.96 36 80834 3006 64414856
Thrombotic microangiopathy 48.35 10.96 80 80790 16575 64401287
Incision site pain 48.35 10.96 34 80836 2620 64415242
Mobility decreased 47.66 10.96 24 80846 85816 64332046
Cerebral reperfusion injury 47.29 10.96 10 80860 16 64417846
Gangrene 47.28 10.96 52 80818 7286 64410576
Ischaemic stroke 46.97 10.96 109 80761 28926 64388936
Shock 46.66 10.96 129 80741 38111 64379751
Decreased appetite 46.58 10.96 188 80682 281101 64136761
Electrocardiogram ST segment elevation 46.01 10.96 51 80819 7208 64410654
Subchorionic haematoma 45.89 10.96 13 80857 100 64417762
Suspected product quality issue 45.80 10.96 16 80854 258 64417604
Intestinal ischaemia 45.61 10.96 64 80806 11485 64406377
Acute respiratory failure 45.48 10.96 152 80718 49782 64368080
Loss of personal independence in daily activities 45.39 10.96 17 80853 72437 64345425
Osteoarthritis 44.76 10.96 12 80858 63324 64354538
Mixed liver injury 44.58 10.96 44 80826 5437 64412425
Anaemia 43.77 10.96 692 80178 377988 64039874
Product contamination 43.72 10.96 23 80847 1046 64416816
Respiratory distress 43.05 10.96 154 80716 52177 64365685
Lymphocyte count decreased 42.64 10.96 130 80740 40569 64377293
Heparin-induced thrombocytopenia test 42.17 10.96 13 80857 138 64417724
Muscle spasms 42.03 10.96 70 80800 140953 64276909
Infective aneurysm 42.02 10.96 21 80849 857 64417005
Anticoagulation drug level below therapeutic 41.98 10.96 24 80846 1288 64416574
Anxiety 41.96 10.96 123 80747 202526 64215336
Foetal death 41.67 10.96 44 80826 5886 64411976
Suspected transmission of an infectious agent via product 41.11 10.96 21 80849 898 64416964
Death 41.10 10.96 397 80473 482308 63935554
Peripheral artery occlusion 40.38 10.96 28 80842 2110 64415752
Pulmonary infarction 40.36 10.96 33 80837 3189 64414673
Antiphospholipid syndrome 40.34 10.96 25 80845 1557 64416305
Blood pressure fluctuation 40.29 10.96 8 80862 51863 64365999
Somnolence 39.74 10.96 127 80743 203518 64214344
Orbital compartment syndrome 39.48 10.96 9 80861 24 64417838
Acute motor-sensory axonal neuropathy 39.45 10.96 16 80854 396 64417466
Splenic rupture 39.44 10.96 28 80842 2191 64415671
Balance disorder 38.89 10.96 29 80841 83897 64333965
Swelling 38.70 10.96 90 80780 160128 64257734
Haemoptysis 38.37 10.96 142 80728 48906 64368956
Vascular stent occlusion 38.20 10.96 13 80857 193 64417669
Impaired healing 38.20 10.96 14 80856 60459 64357403
Anti factor Xa activity decreased 38.15 10.96 8 80862 12 64417850
Blood urea increased 38.10 10.96 132 80738 44021 64373841
Injection site swelling 37.62 10.96 4 80866 41349 64376513
Product quality issue 36.83 10.96 101 80769 29698 64388164
Intra-abdominal haematoma 36.66 10.96 28 80842 2451 64415411
Hemiplegia 36.62 10.96 61 80809 12707 64405155
Rhinorrhoea 36.03 10.96 15 80855 59954 64357908
Platelet count decreased 35.22 10.96 343 80527 167368 64250494
Gastrointestinal necrosis 35.01 10.96 37 80833 4955 64412907
Red blood cells urine positive 34.67 10.96 35 80835 4443 64413419
Hypersensitivity 34.62 10.96 128 80742 196324 64221538
Gastrooesophageal reflux disease 34.49 10.96 32 80838 83111 64334751
Haemorrhagic cerebral infarction 34.10 10.96 21 80849 1293 64416569
Pericarditis 33.92 10.96 18 80852 62498 64355364
Splenic infarction 33.91 10.96 30 80840 3227 64414635
Platelet aggregation inhibition 33.87 10.96 11 80859 140 64417722
Hemiparesis 33.83 10.96 98 80772 29729 64388133
Tachypnoea 33.78 10.96 91 80779 26480 64391382
Spinal subdural haematoma 33.60 10.96 12 80858 207 64417655
Injection site erythema 33.41 10.96 24 80846 70776 64347086
Haemorrhagic stroke 33.29 10.96 51 80819 9900 64407962
Oesophageal intramural haematoma 32.80 10.96 10 80860 102 64417760
Blood creatinine increased 32.69 10.96 286 80584 135496 64282366
Hypervolaemia 32.63 10.96 114 80756 38171 64379691
Brain oedema 32.61 10.96 80 80790 21995 64395867
Discomfort 32.53 10.96 32 80838 80846 64337016
Cardiac procedure complication 32.42 10.96 13 80857 312 64417550
Cerebral hyperperfusion syndrome 32.28 10.96 10 80860 108 64417754
Ischaemic hepatitis 32.02 10.96 29 80841 3217 64414645
Medical device site thrombosis 31.87 10.96 8 80862 36 64417826
Ill-defined disorder 31.79 10.96 8 80862 44044 64373818
Jugular vein thrombosis 31.61 10.96 31 80839 3800 64414062
Anticoagulation drug level above therapeutic 31.61 10.96 28 80842 3017 64414845
Sinusitis 31.35 10.96 87 80783 145841 64272021
Intentional product misuse 30.97 10.96 27 80843 72268 64345594
Injection site reaction 30.86 10.96 10 80860 46654 64371208
Melaena 30.79 10.96 141 80729 53407 64364455
Embolic stroke 30.78 10.96 40 80830 6671 64411191
Influenza 30.71 10.96 54 80816 106477 64311385
Ocular retrobulbar haemorrhage 30.67 10.96 10 80860 129 64417733
Hepatic enzyme increased 30.57 10.96 74 80796 129869 64287993
Blood loss anaemia 30.41 10.96 59 80811 13833 64404029
Chest wall haematoma 30.36 10.96 13 80857 370 64417492
Tongue haematoma 29.77 10.96 11 80859 210 64417652
Device related thrombosis 29.63 10.96 23 80847 2062 64415800
Activated partial thromboplastin time shortened 29.60 10.96 16 80854 769 64417093
Cardiac valve replacement complication 29.49 10.96 11 80859 216 64417646
Confusional state 29.44 10.96 199 80671 260945 64156917
Embolic cerebral infarction 29.34 10.96 18 80852 1101 64416761
Therapeutic product effect incomplete 29.33 10.96 53 80817 103429 64314433
Leukocytosis 29.30 10.96 109 80761 37631 64380231
Graft thrombosis 29.09 10.96 13 80857 411 64417451
Back pain 29.02 10.96 189 80681 249982 64167880
Vascular access site haemorrhage 28.96 10.96 7 80863 26 64417836
Neutrophil count increased 28.83 10.96 83 80787 25091 64392771
Bullous haemorrhagic dermatosis 28.65 10.96 8 80862 58 64417804
Hypertransaminasaemia 28.62 10.96 40 80830 7151 64410711
Anti-platelet antibody 28.61 10.96 6 80864 9 64417853
Irritable bowel syndrome 28.53 10.96 6 80864 37363 64380499
Atrial fibrillation 28.49 10.96 334 80536 170755 64247107
Toxoplasmosis 28.46 10.96 24 80846 2420 64415442
Pituitary apoplexy 28.30 10.96 10 80860 167 64417695
Pulmonary haematoma 28.20 10.96 9 80861 108 64417754
Pulmonary artery thrombosis 28.10 10.96 18 80852 1188 64416674
Drug chemical incompatibility 28.08 10.96 8 80862 63 64417799
Rectosigmoid cancer 27.91 10.96 11 80859 252 64417610
Renal failure 27.77 10.96 349 80521 181339 64236523
Spinal cord compression 27.74 10.96 35 80835 5668 64412194
Reperfusion injury 27.56 10.96 10 80860 181 64417681
Acute generalised exanthematous pustulosis 27.54 10.96 57 80813 14001 64403861
Fungal sepsis 27.36 10.96 20 80850 1638 64416224
Procedural hypotension 27.23 10.96 21 80849 1865 64415997
Sleep disorder 27.19 10.96 21 80849 59688 64358174
Cytokine release syndrome 27.15 10.96 72 80798 20757 64397105
Aggression 27.08 10.96 12 80858 46220 64371642
Injection site pruritus 27.04 10.96 7 80863 37819 64380043
Epistaxis 26.98 10.96 213 80657 97918 64319944
Coagulation test abnormal 26.81 10.96 17 80853 1102 64416760
Aortic dissection 26.76 10.96 27 80843 3425 64414437
Blood albumin decreased 26.61 10.96 72 80798 21001 64396861
Renal haemorrhage 26.56 10.96 21 80849 1934 64415928
Hyperkalaemia 26.44 10.96 217 80653 100912 64316950
Hepatic infarction 26.34 10.96 15 80855 799 64417063
Incorrect drug administration rate 26.25 10.96 24 80846 2695 64415167
Oliguria 26.12 10.96 57 80813 14519 64403343
Hepatic haematoma 26.10 10.96 15 80855 813 64417049
Intentional self-injury 25.93 10.96 3 80867 29041 64388821
Paraplegia 25.83 10.96 30 80840 4460 64413402
Prosthetic cardiac valve thrombosis 25.80 10.96 7 80863 45 64417817
Subcapsular renal haematoma 25.75 10.96 14 80856 681 64417181
Diabetes insipidus 25.66 10.96 30 80840 4491 64413371
Basal cell carcinoma 25.60 10.96 4 80866 30834 64387028
Cognitive disorder 25.56 10.96 19 80851 55068 64362794
Psychotic disorder 25.50 10.96 6 80864 34572 64383290
Bronchial haemorrhage 25.45 10.96 17 80853 1205 64416657
Nervous system disorder 25.38 10.96 75 80795 23003 64394859
Cerebral venous sinus thrombosis 25.36 10.96 20 80850 1835 64416027
Premature rupture of membranes 24.93 10.96 27 80843 3717 64414145
Cerebellar haemorrhage 24.92 10.96 23 80847 2614 64415248
Tachycardia 24.89 10.96 292 80578 149287 64268575
Dysgeusia 24.87 10.96 14 80856 47033 64370829
Obstructive shock 24.69 10.96 7 80863 54 64417808
Cerebral mass effect 24.64 10.96 19 80851 1687 64416175
Autoimmune heparin-induced thrombocytopenia 24.48 10.96 5 80865 6 64417856
Abnormal behaviour 24.47 10.96 6 80864 33616 64384246
Sopor 24.28 10.96 4 80866 29657 64388205
Stevens-Johnson syndrome 24.19 10.96 96 80774 34153 64383709
Hydrocephalus 24.13 10.96 38 80832 7553 64410309
Procedural complication 23.98 10.96 37 80833 7228 64410634
Dermatitis bullous 23.76 10.96 49 80821 12005 64405857
Intracranial haematoma 23.70 10.96 14 80856 799 64417063
Platelet transfusion 23.64 10.96 19 80851 1792 64416070
Caesarean section 23.61 10.96 47 80823 11227 64406635
Wrong technique in product usage process 23.58 10.96 28 80842 64946 64352916
Treatment failure 23.37 10.96 72 80798 116744 64301118
Dry mouth 23.05 10.96 25 80845 60393 64357469
Mediastinal haematoma 23.05 10.96 9 80861 201 64417661
Hypovolaemic shock 22.96 10.96 44 80826 10222 64407640
Herpes zoster 22.94 10.96 40 80830 79147 64338715
Aneurysm ruptured 22.93 10.96 14 80856 849 64417013
Arterial intramural haematoma 22.82 10.96 7 80863 73 64417789
Cholestasis 22.79 10.96 114 80756 44758 64373104
Visual impairment 22.78 10.96 36 80834 74041 64343821
Acquired antithrombin III deficiency 22.73 10.96 4 80866 0 64417862
Hot flush 22.70 10.96 15 80855 46220 64371642
Injury 22.69 10.96 22 80848 55970 64361892
Pancreatic haemorrhage 22.57 10.96 7 80863 76 64417786
Ischaemia 22.54 10.96 36 80834 7242 64410620
Device related sepsis 22.52 10.96 30 80840 5125 64412737
COVID-19 pneumonia 22.48 10.96 58 80812 16446 64401416
Infusion related reaction 22.39 10.96 118 80752 164349 64253513
Blood cholesterol increased 22.30 10.96 18 80852 50048 64367814
Drug dependence 22.27 10.96 7 80863 33305 64384557
Kounis syndrome 22.25 10.96 23 80847 3002 64414860
Delayed graft function 22.18 10.96 23 80847 3013 64414849
Renal artery thrombosis 22.17 10.96 11 80859 442 64417420
Unresponsive to stimuli 22.14 10.96 123 80747 50270 64367592
Renal vein thrombosis 22.08 10.96 11 80859 446 64417416
Protein urine present 22.05 10.96 40 80830 8916 64408946
Petechiae 21.90 10.96 62 80808 18564 64399298
Therapeutic product effect increased 21.74 10.96 16 80854 1324 64416538
Peliosis hepatis 21.71 10.96 7 80863 87 64417775
Transcription medication error 21.67 10.96 10 80860 341 64417521
Cerebral artery embolism 21.21 10.96 17 80853 1597 64416265
Gastrointestinal disorder 21.17 10.96 51 80819 89658 64328204
Gastric haemorrhage 21.14 10.96 50 80820 13431 64404431
Cough 21.06 10.96 260 80610 301888 64115974
Retinal pigment epitheliopathy 21.04 10.96 10 80860 365 64417497
Medical device site haemorrhage 20.99 10.96 8 80862 167 64417695
Peritoneal haematoma 20.95 10.96 8 80862 168 64417694
Cataract 20.94 10.96 20 80850 51242 64366620
Dry gangrene 20.90 10.96 13 80857 815 64417047
Contusion 20.89 10.96 73 80797 113892 64303970
Iliac artery occlusion 20.86 10.96 9 80861 261 64417601
Vascular graft occlusion 20.80 10.96 12 80858 655 64417207
Brain death 20.79 10.96 28 80842 4833 64413029
Inflammation 20.78 10.96 31 80839 65269 64352593
Heart rate decreased 20.78 10.96 23 80847 55044 64362818
Toxic skin eruption 20.57 10.96 62 80808 19222 64398640
Normal newborn 20.52 10.96 30 80840 5587 64412275
Mucosal erosion 20.51 10.96 18 80852 1916 64415946
Blood phosphorus increased 20.41 10.96 28 80842 4918 64412944
Dehydration 20.25 10.96 174 80696 216589 64201273
Spontaneous haematoma 20.23 10.96 15 80855 1256 64416606
Intrapericardial thrombosis 20.06 10.96 6 80864 57 64417805
Serratia infection 20.02 10.96 16 80854 1497 64416365
Paratonia 19.83 10.96 5 80865 23 64417839
Post procedural haematoma 19.72 10.96 19 80851 2279 64415583
Type 2 diabetes mellitus 19.66 10.96 9 80861 34011 64383851
Wheezing 19.66 10.96 45 80825 80534 64337328
Protein C decreased 19.61 10.96 6 80864 62 64417800
Immune effector cell-associated neurotoxicity syndrome 19.57 10.96 20 80850 2575 64415287
Ascites 19.54 10.96 139 80731 61862 64356000
Circulatory collapse 19.52 10.96 89 80781 33643 64384219
Dyspepsia 19.47 10.96 45 80825 80267 64337595
Osteonecrosis of jaw 19.45 10.96 13 80857 39812 64378050
Poor quality product administered 19.37 10.96 22 80848 3193 64414669
Vascular graft thrombosis 19.36 10.96 8 80862 208 64417654
Irritability 19.33 10.96 11 80859 36735 64381127
Cerebral amyloid angiopathy 19.32 10.96 9 80861 314 64417548
Dyspnoea 19.31 10.96 722 80148 717952 63699910
Cerebral artery occlusion 19.13 10.96 16 80854 1595 64416267
Aneurysm recanalisation 19.07 10.96 4 80866 6 64417856
Choroidal effusion 19.06 10.96 11 80859 601 64417261
Bleeding time prolonged 18.88 10.96 14 80856 1172 64416690
Infection 18.82 10.96 145 80725 184735 64233127
Pruritus 18.81 10.96 277 80593 312123 64105739
Abdominal compartment syndrome 18.68 10.96 15 80855 1413 64416449
Subcutaneous haematoma 18.48 10.96 19 80851 2464 64415398
Catheter site haematoma 18.48 10.96 9 80861 347 64417515
Abdominal pain upper 18.42 10.96 136 80734 174894 64242968
Tooth disorder 18.38 10.96 3 80867 22399 64395463
Mean cell haemoglobin concentration 18.32 10.96 5 80865 33 64417829
False negative investigation result 18.26 10.96 8 80862 241 64417621
Foetal growth restriction 18.14 10.96 16 80854 1714 64416148
Mouth ulceration 18.11 10.96 9 80861 32435 64385427
Tonsillar haemorrhage 18.08 10.96 8 80862 247 64417615
Live birth 18.05 10.96 42 80828 11162 64406700
Agitation 18.01 10.96 54 80816 88313 64329549
Breast cancer 17.98 10.96 7 80863 29141 64388721
Ventricular asystole 17.90 10.96 8 80862 253 64417609
Dry eye 17.85 10.96 7 80863 29012 64388850
Adverse event 17.84 10.96 14 80856 39475 64378387
Vision blurred 17.83 10.96 56 80814 90260 64327602
Hypernatraemia 17.82 10.96 44 80826 12145 64405717
No adverse event 17.77 10.96 77 80793 28484 64389378
Treatment noncompliance 17.72 10.96 17 80853 43465 64374397
Primary adrenal insufficiency 17.70 10.96 6 80864 88 64417774
Upper gastrointestinal haemorrhage 17.55 10.96 89 80781 35131 64382731
Dysstasia 17.17 10.96 4 80866 23211 64394651
Bronchitis 17.15 10.96 74 80796 108669 64309193
International normalised ratio increased 17.13 10.96 163 80707 79004 64338858
Malignant neoplasm progression 17.08 10.96 78 80792 112793 64305069
Anisochromia 17.05 10.96 3 80867 0 64417862
Acne 17.03 10.96 4 80866 23077 64394785
Fibromyalgia 17.00 10.96 12 80858 35719 64382143
Complications of transplanted kidney 16.99 10.96 27 80843 5408 64412454
Drug withdrawal syndrome 16.99 10.96 9 80861 31282 64386580
Burkholderia test positive 16.96 10.96 10 80860 569 64417293
Cerebral venous thrombosis 16.95 10.96 18 80852 2423 64415439
Red blood cell sedimentation rate increased 16.93 10.96 9 80861 31226 64386636
Livedo reticularis 16.90 10.96 22 80848 3675 64414187
Arterial rupture 16.89 10.96 11 80859 747 64417115
Nausea 16.80 10.96 810 80060 784990 63632872
Depressed mood 16.75 10.96 16 80854 40996 64376866
Rash morbilliform 16.71 10.96 26 80844 5115 64412747
Haemodialysis complication 16.71 10.96 8 80862 297 64417565
Leg amputation 16.62 10.96 21 80849 3406 64414456
Acute right ventricular failure 16.58 10.96 8 80862 302 64417560
Gestational hypertension 16.55 10.96 15 80855 1666 64416196
Thrombin time abnormal 16.52 10.96 4 80866 15 64417847
Osteoporosis 16.52 10.96 17 80853 42063 64375799
Haemoglobin increased 16.48 10.96 26 80844 5175 64412687
White blood cell count decreased 16.44 10.96 123 80747 157714 64260148
Paraesthesia 16.42 10.96 100 80770 134422 64283440
Fibrin D dimer increased 16.38 10.96 30 80840 6735 64411127
Premature labour 16.24 10.96 32 80838 7588 64410274
Enterococcal infection 16.15 10.96 46 80824 13820 64404042
Urea renal clearance decreased 16.12 10.96 4 80866 17 64417845
Pericardial effusion 16.05 10.96 94 80776 39160 64378702
Renal impairment 16.02 10.96 248 80622 134769 64283093
Subclavian vein thrombosis 15.96 10.96 17 80853 2297 64415565
Palpitations 15.93 10.96 72 80798 104416 64313446
Cardiovascular insufficiency 15.88 10.96 18 80852 2606 64415256
Coronary artery aneurysm 15.75 10.96 6 80864 125 64417737
Transfusion 15.70 10.96 54 80816 17940 64399922
Intracranial pressure increased 15.69 10.96 30 80840 6959 64410903
Tremor 15.68 10.96 115 80755 148115 64269747
Stillbirth 15.65 10.96 21 80849 3612 64414250
Alveolitis necrotising 15.59 10.96 4 80866 20 64417842
Haemorrhage subcutaneous 15.51 10.96 23 80847 4338 64413524
Urethral fistula 15.43 10.96 4 80866 21 64417841
Acute pulmonary oedema 15.41 10.96 43 80827 12766 64405096
Alanine aminotransferase decreased 15.35 10.96 13 80857 1319 64416543
Platelet dysfunction 15.35 10.96 8 80862 357 64417505
Incision site haematoma 15.24 10.96 6 80864 137 64417725
HELLP syndrome 15.22 10.96 10 80860 689 64417173
Peritonitis 15.22 10.96 67 80803 24956 64392906
Accidental exposure to product 15.19 10.96 7 80863 26357 64391505
Vertigo 15.18 10.96 32 80838 58979 64358883
Pelvic haematoma 15.17 10.96 10 80860 693 64417169
Coronary artery dissection 15.07 10.96 11 80859 899 64416963
Adverse drug reaction 15.04 10.96 21 80849 45443 64372419
Gastric disorder 14.99 10.96 9 80861 29188 64388674
Capillary fragility test 14.98 10.96 4 80866 24 64417838
Hand amputation 14.97 10.96 3 80867 3 64417859
Overdose 14.93 10.96 128 80742 159438 64258424
Pulse absent 14.92 10.96 34 80836 8912 64408950
Myiasis 14.84 10.96 4 80866 25 64417837
Emotional distress 14.79 10.96 14 80856 36024 64381838
Body temperature decreased 14.76 10.96 7 80863 25921 64391941
Haemobilia 14.72 10.96 8 80862 389 64417473
Cerebrovascular disorder 14.66 10.96 20 80850 3495 64414367
Haemorrhagic cholecystitis 14.65 10.96 5 80865 75 64417787
Multiple sclerosis relapse 14.64 10.96 18 80852 41117 64376745
Influenza like illness 14.61 10.96 35 80835 61667 64356195
Gait inability 14.59 10.96 19 80851 42349 64375513
Threatened labour 14.59 10.96 9 80861 556 64417306
Platelet aggregation abnormal 14.57 10.96 4 80866 27 64417835
Thrombectomy 14.57 10.96 7 80863 262 64417600
Neuropathy peripheral 14.53 10.96 87 80783 117438 64300424
Injection site plaque 14.52 10.96 5 80865 77 64417785
Blood thrombin increased 14.51 10.96 3 80867 4 64417858
Speech disorder 14.46 10.96 24 80846 48417 64369445
Blood blister 14.29 10.96 17 80853 2591 64415271
Pulmonary fibrosis 14.26 10.96 10 80860 29868 64387994
Right ventricular failure 14.22 10.96 59 80811 21412 64396450
Sleep apnoea syndrome 14.22 10.96 10 80860 29822 64388040
Pseudomonas infection 14.17 10.96 52 80818 17831 64400031
Pulmonary oedema 14.17 10.96 156 80714 78518 64339344
Stomatitis 14.16 10.96 80 80790 109525 64308337
Stress cardiomyopathy 14.15 10.96 34 80836 9223 64408639
Microstomia 14.11 10.96 3 80867 5 64417857
Orthostatic hypotension 14.10 10.96 23 80847 46715 64371147
Nasal congestion 14.00 10.96 34 80836 59624 64358238
Nervousness 13.96 10.96 10 80860 29546 64388316
Cholestatic liver injury 13.95 10.96 20 80850 3659 64414203
Breast haematoma 13.94 10.96 6 80864 173 64417689
Carotid intima-media thickness increased 13.91 10.96 5 80865 88 64417774
Inferior vena caval occlusion 13.87 10.96 4 80866 33 64417829
Graft haemorrhage 13.81 10.96 5 80865 90 64417772
Blood pressure increased 13.76 10.96 144 80726 172408 64245454
Cerebellar embolism 13.76 10.96 3 80867 6 64417856
Migraine 13.73 10.96 37 80833 62640 64355222
Hyperlactacidaemia 13.70 10.96 23 80847 4821 64413041
Phaeochromocytoma crisis 13.69 10.96 7 80863 300 64417562
Thrombolysis 13.69 10.96 6 80864 181 64417681
Drug ineffective for unapproved indication 13.68 10.96 76 80794 31057 64386805
Brain stem infarction 13.66 10.96 14 80856 1809 64416053
Night sweats 13.66 10.96 15 80855 36031 64381831
Transmission of an infectious agent via product 13.66 10.96 6 80864 182 64417680
Splenic haemorrhage 13.58 10.96 9 80861 629 64417233
Hypertensive nephropathy 13.55 10.96 10 80860 831 64417031
Delusion 13.53 10.96 3 80867 18011 64399851
Bursitis 13.52 10.96 5 80865 21480 64396382
Extraocular muscle disorder 13.52 10.96 7 80863 308 64417554
Myocardial haemorrhage 13.47 10.96 4 80866 37 64417825
Joint stiffness 13.45 10.96 11 80859 30393 64387469
Amnesia 13.43 10.96 25 80845 48244 64369618
Paradoxical embolism 13.37 10.96 4 80866 38 64417824
Lipoedema 13.36 10.96 6 80864 192 64417670
Distributive shock 13.33 10.96 14 80856 1861 64416001
Heart rate irregular 13.32 10.96 9 80861 27404 64390458
Factor VIII inhibition 13.31 10.96 7 80863 318 64417544
Ventricular arrhythmia 13.29 10.96 29 80841 7386 64410476
Syncope 13.21 10.96 130 80740 157505 64260357
Portal vein thrombosis 13.20 10.96 23 80847 4968 64412894
Left ventricular dysfunction 13.18 10.96 49 80821 16905 64400957
Vascular parkinsonism 13.18 10.96 5 80865 103 64417759
Vascular access site haematoma 13.16 10.96 3 80867 8 64417854
Carotid artery dissection 13.13 10.96 7 80863 327 64417535
Product contamination microbial 13.12 10.96 10 80860 873 64416989
Throat irritation 13.08 10.96 13 80857 32698 64385164
Nightmare 13.02 10.96 5 80865 20988 64396874
Kidney rupture 12.99 10.96 6 80864 205 64417657
Basophil count decreased 12.97 10.96 6 80864 206 64417656
Necrotising oesophagitis 12.94 10.96 9 80861 681 64417181
Hypertriglyceridaemia 12.88 10.96 37 80833 11168 64406694
Antithrombin III deficiency 12.88 10.96 5 80865 110 64417752
Mouth haemorrhage 12.85 10.96 34 80836 9785 64408077
Injection site bruising 12.85 10.96 16 80854 36357 64381505
Hypoxic-ischaemic encephalopathy 12.85 10.96 28 80842 7124 64410738
Eosinophil cationic protein increased 12.85 10.96 4 80866 44 64417818
Thoracic haemorrhage 12.78 10.96 6 80864 213 64417649
Basal ganglia haemorrhage 12.78 10.96 12 80858 1394 64416468
Purpura 12.71 10.96 49 80821 17197 64400665
Nephrolithiasis 12.71 10.96 22 80848 43661 64374201
Platelet disorder 12.69 10.96 15 80855 2272 64415590
Product preparation error 12.66 10.96 20 80850 3985 64413877
Ruptured cerebral aneurysm 12.61 10.96 8 80862 519 64417343
Klebsiella infection 12.60 10.96 41 80829 13240 64404622
COVID-19 12.58 10.96 131 80739 65009 64352853
Diabetes mellitus 12.57 10.96 42 80828 66432 64351430
Blood pressure systolic increased 12.57 10.96 27 80843 49426 64368436
Aspartate aminotransferase decreased 12.56 10.96 10 80860 930 64416932
Dystonia 12.55 10.96 4 80866 18861 64399001
Kidney transplant rejection 12.52 10.96 33 80837 9478 64408384
Spinal cord haemorrhage 12.50 10.96 8 80862 527 64417335
Respiratory tract oedema 12.49 10.96 9 80861 721 64417141
Postpartum haemorrhage 12.49 10.96 12 80858 1435 64416427
Manufacturing materials issue 12.44 10.96 3 80867 11 64417851
Myelomalacia 12.36 10.96 5 80865 123 64417739
Food interaction 12.35 10.96 12 80858 1454 64416408
Nutritional condition abnormal 12.32 10.96 10 80860 956 64416906
Fear 12.19 10.96 5 80865 20166 64397696
Bone disorder 12.18 10.96 3 80867 16756 64401106
Peripheral artery aneurysm 12.14 10.96 7 80863 382 64417480
Hepatic cytolysis 12.11 10.96 42 80828 14007 64403855
Electrocardiogram T wave alternans 12.10 10.96 4 80866 54 64417808
Femur fracture 12.08 10.96 15 80855 34120 64383742
Arterial injury 12.04 10.96 8 80862 562 64417300
Skin ulcer 12.03 10.96 23 80847 43951 64373911
Bacteraemia 12.03 10.96 66 80804 26845 64391017
Sedation 11.96 10.96 21 80849 41441 64376421
Traumatic haemothorax 11.95 10.96 7 80863 393 64417469
White blood cell count increased 11.93 10.96 131 80739 65883 64351979
Ulcer 11.92 10.96 7 80863 22983 64394879
Vaginal haemorrhage 11.92 10.96 52 80818 19292 64398570
Activated partial thromboplastin time abnormal 11.91 10.96 6 80864 249 64417613
Venous thrombosis limb 11.91 10.96 19 80851 3818 64414044
Foot deformity 11.90 10.96 3 80867 16501 64401361
Pneumonia escherichia 11.89 10.96 9 80861 777 64417085
Ergot poisoning 11.85 10.96 5 80865 137 64417725
Contrast encephalopathy 11.82 10.96 5 80865 138 64417724
Renal tubular necrosis 11.81 10.96 57 80813 22053 64395809
Paranoia 11.74 10.96 3 80867 16349 64401513
Dyspnoea exertional 11.73 10.96 50 80820 73680 64344182
Ureteric haemorrhage 11.69 10.96 3 80867 15 64417847
Septic rash 11.69 10.96 3 80867 15 64417847
Femoral nerve palsy 11.66 10.96 4 80866 61 64417801
Platelet aggregation test 11.66 10.96 4 80866 61 64417801
Extravasation 11.64 10.96 17 80853 3163 64414699
Blister 11.63 10.96 57 80813 80910 64336952
Tracheal haemorrhage 11.59 10.96 8 80862 598 64417264
Coronary artery occlusion 11.52 10.96 41 80829 13850 64404012
Cerebral artery thrombosis 11.52 10.96 10 80860 1049 64416813
Blood sodium decreased 11.47 10.96 12 80858 29470 64388392
Anaphylactoid reaction 11.46 10.96 21 80849 4717 64413145
Abortion early 11.38 10.96 3 80867 17 64417845
Cardiac failure 11.37 10.96 231 80639 132142 64285720
Haematidrosis 11.37 10.96 4 80866 66 64417796
Lumbar puncture 11.34 10.96 5 80865 153 64417709
Spinal cord disorder 11.31 10.96 12 80858 1614 64416248
Premature baby 11.27 10.96 17 80853 3255 64414607
Immune thrombocytopenia 11.26 10.96 43 80827 15023 64402839
Herpes simplex hepatitis 11.26 10.96 7 80863 438 64417424
Fungal disease carrier 11.24 10.96 6 80864 281 64417581
Microangiopathic haemolytic anaemia 11.20 10.96 11 80859 1351 64416511
Staphylococcus test positive 11.19 10.96 23 80847 5622 64412240
Paralysis 11.18 10.96 36 80834 11559 64406303
Mediastinal haemorrhage 11.15 10.96 4 80866 70 64417792
Reperfusion arrhythmia 11.15 10.96 6 80864 286 64417576
Hypoaesthesia 11.13 10.96 116 80754 138992 64278870
Toothache 11.09 10.96 4 80866 17455 64400407
Anger 11.09 10.96 3 80867 15738 64402124
Organic brain syndrome 11.08 10.96 7 80863 451 64417411
Renal artery stenosis 11.05 10.96 16 80854 2953 64414909
Hyperglycaemia 11.02 10.96 121 80749 60847 64357015
Pituitary haemorrhage 10.99 10.96 6 80864 294 64417568
Movement disorder 10.99 10.96 7 80863 21993 64395869
Subdural haemorrhage 10.98 10.96 22 80848 5281 64412581

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AB01 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Heparin group
ATC B01AB51 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Heparin group
ATC C05BA03 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
ANTIVARICOSE THERAPY
Heparins or heparinoids for topical use
ATC C05BA53 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
ANTIVARICOSE THERAPY
Heparins or heparinoids for topical use
ATC S01XA14 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA CS M0010187 Heparin
FDA EPC N0000175474 Unfractionated Heparin
MeSH PA D000925 Anticoagulants
MeSH PA D002317 Cardiovascular Agents
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
FDA EPC N0000175980 Anti-coagulant
CHEBI has role CHEBI:50249 anticoagulants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Disseminated intravascular coagulation indication 67406007 DOID:11247
Deep venous thrombosis indication 128053003
Pulmonary thromboembolism indication 233935004
Peripheral arterial embolism indication 286959000
Non-Q wave myocardial infarction indication 314207007
Prevention of deep vein thrombosis indication 439993001
Deep Vein Thrombosis with Pulmonary Embolism indication
Prevention of Recurrent Venous Thrombosis Associated with Malignancy indication
Pulmonary Thromboembolism Prevention indication
Peripheral Arterial Thromboembolism Prevention indication
Maintain Patency of Indwelling Vascular Catheter indication
Prevention of Ischemic Complications of Non-Q Wave MI indication
Prevention of Cardiac Ischemia in Unstable Angina indication
Myocardial infarction off-label use 22298006 DOID:5844
Coronavirus infection off-label use 186747009
Acute coronary syndrome off-label use 394659003
Percutaneous coronary intervention off-label use 415070008
Intracranial hemorrhage contraindication 1386000
Diabetic retinopathy contraindication 4855003 DOID:8947
Hypertensive retinopathy contraindication 6962006 DOID:11561
Retinal disorder contraindication 29555009 DOID:5679
Antithrombin III deficiency contraindication 36351005 DOID:3755
Gastrointestinal ulcer contraindication 40845000
Threatened abortion contraindication 54048003 DOID:9667
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Osteoporosis contraindication 64859006 DOID:11476
Operation on brain contraindication 70586009
Heparin-induced thrombocytopenia contraindication 73397007
Gastrointestinal hemorrhage contraindication 74474003
Ulceration of intestine contraindication 85942002
Acute gastric ulcer with hemorrhage contraindication 89748001
Hemophilia contraindication 90935002
Disorder of biliary tract contraindication 105997008 DOID:9741
Procedure on central nervous system contraindication 118679007
Bleeding contraindication 131148009
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Hemorrhagic cerebral infarction contraindication 230706003
Local anesthetic intrathecal block contraindication 231249005
Infective endocarditis contraindication 233850007
Procedure on spine contraindication 238181003
Qualitative platelet disorder contraindication 267532001
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral hemorrhage contraindication 274100004
Lumbar puncture contraindication 277762005
Bacterial endocarditis contraindication 301183007
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Dissection of aorta contraindication 308546005
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Surgical procedure on eye proper contraindication 373353005
Hypertensive urgency contraindication 443482000
Placement of Epidural Catheter contraindication
Thrombosis in Heparin Induced Thrombocytopenia contraindication
Platelet Aggregation Inhibition contraindication
Spinal Epidural Hematoma contraindication
Significant Bleeding contraindication
Indwelling Vascular Catheter contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Antithrombin-III Secreted ACTIVATOR Kd 7.85 IUPHAR CHEMBL
Spike glycoprotein Glycoprotein Kd 10.14 IUPHAR
Spike glycoprotein, S glycoprotein Unclassified Kd 6.30 IUPHAR

External reference:

IDSource
D02112 KEGG_DRUG
4017546 VANDF
4017547 VANDF
4017549 VANDF
4018538 VANDF
C0019134 UMLSCUI
CHEBI:28304 CHEBI
CHEMBL1909300 ChEMBL_ID
CHEMBL4650299 ChEMBL_ID
CHEMBL1201657 ChEMBL_ID
D006493 MESH_DESCRIPTOR_UI
DB01109 DRUGBANK_ID
4214 IUPHAR_LIGAND_ID
37270-89-6 SECONDARY_CAS_RN
T2410KM04A UNII
92044406 PUBCHEM_CID
20044 RXNORM
3649 MMSL
4821 MMSL
d00252 MMSL
002079 NDDF
002081 NDDF
015153 NDDF
29725000 SNOMEDCT_US
372877000 SNOMEDCT_US
412201008 SNOMEDCT_US
412401006 SNOMEDCT_US
50045009 SNOMEDCT_US
784398008 SNOMEDCT_US
84812008 SNOMEDCT_US
CHEMBL1201513 ChEMBL_ID
M7J PDB_CHEM_ID
392 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0043 INJECTION 1000 [USPU] INTRAVENOUS NDA 26 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0058 INJECTION 1000 [USPU] INTRAVENOUS NDA 26 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0059 INJECTION 5000 [USPU] INTRAVENOUS NDA 26 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0062 INJECTION 10000 [USPU] INTRAVENOUS NDA 26 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0137 INJECTION 1000 [USPU] INTRAVENOUS NDA 26 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0264-5705 INJECTION 5000 [USPU] INTRAVENOUS ANDA 20 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9567 INJECTION 4000 [USPU] INTRAVENOUS NDA 19 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9577 INJECTION 5000 [USPU] INTRAVENOUS NDA 19 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9587 INJECTION 10000 [USPU] INTRAVENOUS NDA 19 sections
Heparin Sodium in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-9872 INJECTION 200 [USPU] INTRAVENOUS NDA 23 sections
HEPARIN SODIUM IN SODIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0424 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA 26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0428 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA 26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0431 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA 26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0433 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA 26 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0404-9872 INJECTION, SOLUTION 5000 [USPU] INTRAVENOUS ANDA 14 sections
HEPARIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0404-9873 INJECTION 10000 [USPU] INTRAVENOUS ANDA 14 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0404-9979 INJECTION, SOLUTION 1000 [USPU] INTRAVENOUS NDA 16 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-1316 INJECTION, SOLUTION 10000 [USPU] SUBCUTANEOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-1402 INJECTION, SOLUTION 5000 [USPU] SUBCUTANEOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-2720 INJECTION, SOLUTION 1000 [USPU] SUBCUTANEOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-2721 INJECTION, SOLUTION 10000 [USPU] INTRAVENOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-2723 INJECTION, SOLUTION 5000 [USPU] SUBCUTANEOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7620 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA 27 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7650 INJECTION, SOLUTION 10000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7651 INJECTION, SOLUTION 5000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium and Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0409-7793 INJECTION, SOLUTION 10000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium and Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0409-7794 INJECTION, SOLUTION 5000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0391 INJECTION 1000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0400 INJECTION 5000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0410 INJECTION 10000 [USPU] INTRAVENOUS NDA 24 sections