All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

heparin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
heparin derivatives including low molecular mass heparins	1358	9005-49-6

Description:

Molecule

Description

Synonyms: heparin heparin sodium heparin calcium

A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
10	TU	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 9, 1939	FDA	ORGANON USA INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heparin-induced thrombocytopenia	2299.17	11.38	563	44520	3402	50556639
Premature delivery	303.46	11.38	214	44869	23449	50536592
Shock haemorrhagic	229.74	11.38	123	44960	8221	50551820
Haemorrhage	216.01	11.38	252	44831	53189	50506852
Hereditary angioedema	210.64	11.38	101	44982	5341	50554700
Labelled drug-drug interaction medication error	201.06	11.38	122	44961	10355	50549686
Maternal exposure during pregnancy	189.76	11.38	431	44652	159347	50400694
Thrombocytopenia	182.10	11.38	371	44712	127302	50432739
Vascular stent thrombosis	182.08	11.38	56	45027	853	50559188
Exposure during pregnancy	170.61	11.38	350	44733	120665	50439376
Rheumatoid arthritis	161.56	11.38	4	45079	202546	50357495
Retroperitoneal haematoma	149.76	11.38	64	45019	2579	50557462
Cerebral haemorrhage	146.71	11.38	149	44934	26903	50533138
Pulmonary embolism	146.68	11.38	297	44786	101407	50458634
Retroperitoneal haemorrhage	145.18	11.38	62	45021	2494	50557547
Abdominal wall haematoma	144.99	11.38	63	45020	2645	50557396
Haematoma	142.20	11.38	155	44928	30355	50529686
Joint swelling	133.39	11.38	28	45055	245258	50314783
Haemorrhage intracranial	131.62	11.38	100	44983	12274	50547767
Drug intolerance	119.14	11.38	25	45058	219079	50340962
Arthropathy	115.95	11.38	6	45077	157900	50402141
Thrombosis in device	115.67	11.38	54	45029	2687	50557354
Arthralgia	114.13	11.38	134	44949	438568	50121473
Vascular pseudoaneurysm	110.98	11.38	43	45040	1341	50558700
Acute kidney injury	110.89	11.38	449	44634	227609	50332432
Extradural haematoma	108.70	11.38	44	45039	1543	50558498
Alopecia	99.45	11.38	47	45036	245000	50315041
Thrombosis	97.59	11.38	177	44906	55656	50504385
Multiple organ dysfunction syndrome	96.27	11.38	166	44917	50171	50509870
Completed suicide	93.79	11.38	6	45077	131883	50428158
Pemphigus	93.45	11.38	3	45080	120163	50439878
Product use in unapproved indication	93.21	11.38	270	44813	115549	50444492
Cerebral infarction	92.47	11.38	105	44978	21499	50538542
Premature baby	90.42	11.38	96	44987	18241	50541800
Haemoperitoneum	88.61	11.38	44	45039	2511	50557530
Activated partial thromboplastin time prolonged	82.26	11.38	58	45025	6344	50553697
Haematoma muscle	81.87	11.38	29	45054	699	50559342
Cardiogenic shock	81.08	11.38	84	44999	15515	50544526
Compartment syndrome	80.40	11.38	38	45045	1944	50558097
Spinal epidural haematoma	80.27	11.38	31	45052	958	50559083
Pain	78.39	11.38	260	44823	578643	49981398
Cardiac arrest	78.17	11.38	206	44877	83445	50476596
Haemothorax	77.63	11.38	37	45046	1929	50558112
Abdominal discomfort	76.28	11.38	57	45026	231584	50328457
Systemic lupus erythematosus	74.45	11.38	17	45066	140605	50419436
Pharyngeal haemorrhage	74.39	11.38	25	45058	512	50559529
Aplastic anaemia	70.56	11.38	57	45026	7646	50552395
Off label use	70.17	11.38	687	44396	473739	50086302
Toxic epidermal necrolysis	70.17	11.38	90	44993	20902	50539139
Foetal death	65.51	11.38	56	45027	8124	50551917
Low birth weight baby	63.58	11.38	48	45035	5833	50554208
Cardiac tamponade	63.03	11.38	42	45041	4190	50555851
Heparin-induced thrombocytopenia test positive	62.86	11.38	11	45072	4	50560037
Subdural haematoma	62.45	11.38	67	45016	12880	50547161
Hypotension	61.98	11.38	390	44693	235079	50324962
Subarachnoid haemorrhage	57.76	11.38	59	45024	10717	50549324
Infective aneurysm	56.96	11.38	19	45064	380	50559661
Disseminated intravascular coagulation	56.54	11.38	73	45010	17062	50542979
Embolism	56.41	11.38	48	45035	6920	50553121
Sepsis	56.17	11.38	251	44832	132674	50427367
Haemoglobin decreased	54.34	11.38	241	44842	126975	50433066
Wound	53.63	11.38	14	45069	105780	50454261
Hypersensitivity	52.35	11.38	69	45014	215092	50344949
Drug ineffective	52.02	11.38	474	44609	818859	49741182
Pericarditis	51.95	11.38	5	45078	78684	50481357
Coronary artery thrombosis	51.24	11.38	23	45060	1044	50558997
Respiratory failure	51.12	11.38	188	44895	90993	50469048
Peripheral ischaemia	50.94	11.38	37	45046	4239	50555802
Hypoxia	50.93	11.38	129	44954	50994	50509047
Coagulation time shortened	50.81	11.38	14	45069	141	50559900
Caesarean section	50.62	11.38	66	45017	15573	50544468
Acute motor-sensory axonal neuropathy	50.39	11.38	16	45067	272	50559769
Eosinophilia	50.22	11.38	72	45011	18580	50541461
Choroidal infarction	48.86	11.38	12	45071	73	50559968
Subchorionic haematoma	48.59	11.38	13	45070	116	50559925
Fatigue	48.12	11.38	402	44681	707199	49852842
Deep vein thrombosis	47.89	11.38	159	44924	73145	50486896
Treatment failure	46.39	11.38	33	45050	137604	50422437
Procedural haemorrhage	46.28	11.38	28	45055	2362	50557679
Coagulation time prolonged	46.17	11.38	22	45061	1146	50558895
Intracardiac thrombus	45.91	11.38	27	45056	2162	50557879
Encephalopathy	45.64	11.38	96	44987	33615	50526426
Weight increased	44.89	11.38	69	45014	201822	50358219
Gastrointestinal haemorrhage	44.35	11.38	155	44928	73166	50486875
Orbital compartment syndrome	44.35	11.38	9	45074	18	50560023
Adrenal haemorrhage	44.32	11.38	16	45067	408	50559633
Psoriasis	43.96	11.38	5	45078	68995	50491046
Skin necrosis	43.44	11.38	51	45032	10816	50549225
Muscle haemorrhage	43.20	11.38	29	45054	2929	50557112
Musculoskeletal stiffness	43.05	11.38	31	45052	128450	50431591
Arthritis	42.96	11.38	12	45071	86709	50473332
Rash	42.55	11.38	223	44860	437248	50122793
Nasopharyngitis	41.88	11.38	67	45016	192860	50367181
Pulmonary alveolar haemorrhage	41.62	11.38	32	45051	3995	50556046
Acute myocardial infarction	41.55	11.38	85	44998	29188	50530853
Swelling	41.53	11.38	72	45011	200800	50359241
Intentional overdose	41.18	11.38	4	45079	62500	50497541
Foetal exposure during pregnancy	40.69	11.38	81	45002	27278	50532763
Injection site pain	39.59	11.38	25	45058	110999	50449042
Coagulopathy	39.41	11.38	63	45020	17881	50542160
Blood pressure decreased	38.97	11.38	124	44959	55785	50504256
Lower respiratory tract infection	38.96	11.38	18	45065	95183	50464858
Anaemia	38.83	11.38	369	44714	252087	50307954
Cerebral haematoma	38.74	11.38	28	45055	3183	50556858
Platelet aggregation inhibition	38.72	11.38	11	45072	125	50559916
Pulmonary infarction	38.64	11.38	25	45058	2373	50557668
HELLP syndrome	38.45	11.38	18	45065	901	50559140
Ischaemic stroke	37.82	11.38	58	45025	15890	50544151
Gait disturbance	37.61	11.38	47	45036	149958	50410083
Cardiac valve replacement complication	37.44	11.38	11	45072	142	50559899
Brain herniation	37.39	11.38	27	45056	3065	50556976
Gangrene	37.32	11.38	32	45051	4660	50555381
Spinal cord compression	37.30	11.38	29	45054	3680	50556361
Rectosigmoid cancer	36.95	11.38	11	45072	149	50559892
Venous thrombosis	36.63	11.38	31	45052	4435	50555606
Toxoplasmosis	36.52	11.38	20	45063	1397	50558644
Drug abuse	36.51	11.38	5	45078	59841	50500200
Discomfort	36.50	11.38	26	45057	108354	50451687
Toxicity to various agents	36.37	11.38	85	44998	212414	50347627
Ocular retrobulbar haemorrhage	36.26	11.38	10	45073	101	50559940
Mobility decreased	36.15	11.38	13	45070	79935	50480106
Hepatic enzyme increased	35.54	11.38	42	45041	137338	50422703
Haemorrhagic transformation stroke	35.24	11.38	18	45065	1091	50558950
Platelet count decreased	35.12	11.38	180	44903	100546	50459495
Mixed liver injury	34.74	11.38	27	45056	3424	50556617
Thrombotic microangiopathy	34.72	11.38	41	45042	8750	50551291
Spinal subdural haematoma	34.63	11.38	10	45073	121	50559920
Electrocardiogram ST segment elevation	34.59	11.38	27	45056	3446	50556595
Aortic thrombosis	34.20	11.38	17	45066	972	50559069
Loss of personal independence in daily activities	34.13	11.38	10	45073	70040	50490001
Oesophageal intramural haematoma	34.08	11.38	9	45074	76	50559965
Splenic rupture	33.93	11.38	18	45065	1180	50558861
Rash maculo-papular	33.91	11.38	74	45009	26567	50533474
Hypercoagulation	33.63	11.38	21	45062	1874	50558167
Depression	33.54	11.38	60	45023	165363	50394678
Product dose omission issue	33.53	11.38	71	45012	183767	50376274
Hyperlactacidaemia	33.50	11.38	23	45060	2410	50557631
Stevens-Johnson syndrome	33.07	11.38	65	45018	21687	50538354
Suicidal ideation	32.92	11.38	5	45078	55380	50504661
Blood cholesterol increased	32.78	11.38	5	45078	55210	50504831
Malaise	32.60	11.38	171	44912	335361	50224680
Antiphospholipid syndrome	32.58	11.38	19	45064	1498	50558543
Vena cava thrombosis	32.39	11.38	21	45062	2000	50558041
Tonsillar haemorrhage	32.25	11.38	11	45072	236	50559805
Tachypnoea	31.77	11.38	51	45032	14526	50545515
Puncture site haemorrhage	31.49	11.38	11	45072	254	50559787
Paraplegia	30.99	11.38	22	45061	2432	50557609
Pericardial haemorrhage	30.62	11.38	18	45065	1440	50558601
Transcription medication error	30.60	11.38	10	45073	187	50559854
Contraindicated product administered	30.22	11.38	54	45029	148904	50411137
Product administration error	30.11	11.38	59	45024	19640	50540401
Suicide attempt	30	11.38	5	45078	51727	50508314
Incorrect drug administration rate	29.80	11.38	22	45061	2584	50557457
Irritable bowel syndrome	29.77	11.38	5	45078	51436	50508605
Septic shock	29.63	11.38	115	44968	57060	50502981
Therapeutic product effect incomplete	29.46	11.38	23	45060	91492	50468549
Shock	29.35	11.38	60	45023	20590	50539451
Insomnia	29.07	11.38	71	45012	174794	50385247
Intraventricular haemorrhage	28.92	11.38	19	45064	1851	50558190
Post procedural haemorrhage	28.86	11.38	34	45049	7236	50552805
Impaired healing	28.85	11.38	13	45070	69773	50490268
Oliguria	28.68	11.38	36	45047	8180	50551861
Embolic cerebral infarction	28.44	11.38	12	45071	468	50559573
Intracranial haematoma	28.36	11.38	11	45072	344	50559697
Catheter site haemorrhage	28.32	11.38	22	45061	2788	50557253
Drug chemical incompatibility	28.31	11.38	7	45076	44	50559997
Hypervolaemia	28.21	11.38	67	45016	25432	50534609
Ill-defined disorder	28.13	11.38	7	45076	54647	50505394
Premature rupture of membranes	28.11	11.38	27	45056	4553	50555488
Haemorrhagic infarction	27.70	11.38	10	45073	255	50559786
Arterial thrombosis	27.44	11.38	16	45067	1261	50558780
Respiratory distress	27.35	11.38	74	45009	30415	50529626
Anti factor Xa activity decreased	27.19	11.38	5	45078	4	50560037
Hemiparesis	27.02	11.38	57	45026	19991	50540050
Intra-abdominal haematoma	26.99	11.38	17	45066	1540	50558501
Memory impairment	26.76	11.38	19	45064	79341	50480700
Haemodynamic instability	26.18	11.38	34	45049	7990	50552051
Ventricular tachycardia	26.16	11.38	49	45034	15772	50544269
Peripheral artery thrombosis	25.81	11.38	17	45066	1663	50558378
Choroidal effusion	25.74	11.38	11	45072	443	50559598
Pulseless electrical activity	25.53	11.38	31	45052	6810	50553231
Vasodilatation	25.52	11.38	19	45064	2260	50557781
Peripheral swelling	25.37	11.38	96	44987	205840	50354201
Haemolysis	25.33	11.38	29	45054	5987	50554054
Atrial thrombosis	25.29	11.38	16	45067	1461	50558580
Cholestasis	25.19	11.38	64	45019	25337	50534704
Febrile neutropenia	25.15	11.38	161	44922	97506	50462535
Cerebellar haemorrhage	24.98	11.38	15	45068	1248	50558793
Acute generalised exanthematous pustulosis	24.79	11.38	35	45048	8903	50551138
Asthma	24.53	11.38	26	45057	89311	50470730
Arterial haemorrhage	24.52	11.38	16	45067	1541	50558500
Normal newborn	24.45	11.38	30	45053	6661	50553380
Cerebral amyloid angiopathy	24.36	11.38	8	45075	152	50559889
Injection site swelling	24.31	11.38	4	45079	41769	50518272
Abdominal compartment syndrome	23.79	11.38	11	45072	535	50559506
Lipoedema	23.74	11.38	9	45074	264	50559777
Osteoarthritis	23.70	11.38	16	45067	68590	50491451
Arterial intramural haematoma	23.46	11.38	5	45078	14	50560027
Foetal growth restriction	23.07	11.38	29	45054	6598	50553443
Spinal cord disorder	23.01	11.38	14	45069	1193	50558848
Product measured potency issue	22.86	11.38	7	45076	105	50559936
Renal vein thrombosis	22.83	11.38	9	45074	294	50559747
Haemorrhage subcutaneous	22.67	11.38	19	45064	2682	50557359
Pituitary apoplexy	22.27	11.38	7	45076	115	50559926
Intentional product misuse	22.17	11.38	7	45076	46727	50513314
Stress cardiomyopathy	22.05	11.38	31	45052	7856	50552185
Cerebral venous thrombosis	21.86	11.38	16	45067	1855	50558186
Acute respiratory distress syndrome	21.80	11.38	54	45029	21045	50538996
Ventricular fibrillation	21.73	11.38	36	45047	10523	50549518
Intra-abdominal haemorrhage	21.55	11.38	17	45066	2203	50557838
Paratonia	21.53	11.38	5	45078	23	50560018
Renal infarct	21.47	11.38	14	45069	1346	50558695
Vaginal haemorrhage	21.44	11.38	59	45024	24492	50535549
Cerebral reperfusion injury	21.33	11.38	4	45079	4	50560037
Therapeutic product effect decreased	21.25	11.38	57	45026	135993	50424048
Suspected transmission of an infectious agent via product	21.19	11.38	8	45075	232	50559809
Dizziness	21.11	11.38	202	44881	346167	50213874
Peritoneal haematoma	20.90	11.38	6	45077	71	50559970
Stillbirth	20.65	11.38	26	45057	5926	50554115
Postpartum haemorrhage	20.49	11.38	15	45068	1739	50558302
Product contamination	20.31	11.38	10	45073	560	50559481
Weight decreased	20.22	11.38	115	44968	221130	50338911
Confusional state	20.20	11.38	91	44992	185837	50374204
Acute respiratory failure	20.20	11.38	64	45019	28718	50531323
Coagulation time abnormal	20.17	11.38	6	45077	81	50559960
Subcapsular renal haematoma	20.16	11.38	8	45075	266	50559775
Gastrooesophageal reflux disease	20.15	11.38	23	45060	76405	50483636
Coronary artery perforation	20.14	11.38	5	45078	32	50560009
Vascular access site haemorrhage	20.06	11.38	4	45079	7	50560034
Haematuria	19.88	11.38	59	45024	25554	50534487
Protein C decreased	19.88	11.38	5	45078	34	50560007
Hepatic haematoma	19.80	11.38	9	45074	421	50559620
Drug reaction with eosinophilia and systemic symptoms	19.76	11.38	63	45020	28361	50531680
Splenic infarction	19.73	11.38	14	45069	1546	50558495
Atheroembolism	19.71	11.38	4	45079	8	50560033
Kidney rupture	19.63	11.38	5	45078	36	50560005
Blood pressure fluctuation	19.62	11.38	4	45079	35819	50524222
Myalgia	19.48	11.38	52	45031	124267	50435774
Feeling abnormal	19.28	11.38	53	45030	125439	50434602
Injection site erythema	19.27	11.38	23	45060	74913	50485128
Myelomalacia	19.17	11.38	5	45078	40	50560001
Organic brain syndrome	19.12	11.38	7	45076	186	50559855
Live birth	19.11	11.38	44	45039	16364	50543677
Haemoptysis	18.99	11.38	58	45025	25515	50534526
Calciphylaxis	18.99	11.38	17	45066	2621	50557420
Haemodialysis complication	18.77	11.38	7	45076	196	50559845
Cardiac failure	18.74	11.38	124	44959	75916	50484125
Inflammation	18.70	11.38	14	45069	56898	50503143
Platelet transfusion	18.67	11.38	10	45073	668	50559373
Gastrointestinal disorder	18.47	11.38	35	45048	94421	50465620
Pain in extremity	18.43	11.38	155	44928	272710	50287331
Premature labour	18.30	11.38	35	45048	11441	50548600
Device related infection	18.27	11.38	50	45033	20685	50539356
Blood albumin decreased	18.27	11.38	38	45045	13198	50546843
Bullous haemorrhagic dermatosis	18.09	11.38	5	45078	51	50559990
Ureteric haemorrhage	18.07	11.38	3	45080	0	50560041
Cerebellar embolism	18.07	11.38	3	45080	0	50560041
Hand amputation	18.07	11.38	3	45080	0	50560041
Phaeochromocytoma crisis	18.01	11.38	7	45076	220	50559821
Transfusion	17.75	11.38	37	45046	12868	50547173
Hemiplegia	17.72	11.38	27	45056	7354	50552687
Gestational hypertension	17.65	11.38	15	45068	2158	50557883
Injection site pruritus	17.55	11.38	7	45076	40404	50519637
Mucosal erosion	17.33	11.38	12	45071	1275	50558766
Arm amputation	17.29	11.38	4	45079	18	50560023
Ischaemic hepatitis	17.09	11.38	14	45069	1915	50558126
Product administered to patient of inappropriate age	17.08	11.38	16	45067	2614	50557427
Posthaemorrhagic hydrocephalus	16.95	11.38	4	45079	20	50560021
Procedural complication	16.62	11.38	21	45062	4802	50555239
Wrong technique in product usage process	16.57	11.38	15	45068	55495	50504546
Cholestatic liver injury	16.52	11.38	14	45069	2007	50558034
Injection site plaque	16.39	11.38	5	45078	74	50559967
Capillary fragility test	16.34	11.38	4	45079	24	50560017
Nervous system disorder	16.21	11.38	41	45042	16182	50543859
Anticoagulation drug level below therapeutic	16.13	11.38	9	45074	652	50559389
Hyperkalaemia	16.10	11.38	85	44998	48004	50512037
Aneurysm recanalisation	16.00	11.38	3	45080	3	50560038
Pre-eclampsia	15.99	11.38	27	45056	8017	50552024
COVID-19	15.98	11.38	83	45000	46579	50513462
Neurological symptom	15.87	11.38	20	45063	4562	50555479
Thrombolysis	15.80	11.38	5	45078	84	50559957
Dry gangrene	15.72	11.38	8	45075	481	50559560
Post procedural haematoma	15.55	11.38	11	45072	1209	50558832
Hepatic function abnormal	15.54	11.38	64	45019	32617	50527424
Cerebrovascular disorder	15.45	11.38	15	45068	2563	50557478
Renal failure	15.43	11.38	154	44929	106479	50453562
Herpes simplex hepatitis	15.43	11.38	7	45076	326	50559715
Patent ductus arteriosus	15.39	11.38	18	45065	3802	50556239
Protein S decreased	15.34	11.38	4	45079	32	50560009
Pseudomonas infection	15.34	11.38	29	45054	9401	50550640
Pelvic haematoma	15.23	11.38	8	45075	514	50559527
Hydrocephalus	15.17	11.38	20	45063	4768	50555273
Foetal exposure timing unspecified	15.16	11.38	6	45077	198	50559843
Folliculitis	15.16	11.38	8	45075	39217	50520824
Medical device site thrombosis	15.14	11.38	3	45080	5	50560036
Pulse absent	15.11	11.38	20	45063	4786	50555255
Recurrence of neuromuscular blockade	15.08	11.38	5	45078	98	50559943
Petechiae	15.07	11.38	34	45049	12478	50547563
Cerebral artery thrombosis	15.03	11.38	7	45076	346	50559695
Medical device site haemorrhage	15.02	11.38	4	45079	35	50560006
Obstructive shock	15.02	11.38	4	45079	35	50560006
Cerebral artery embolism	14.95	11.38	9	45074	752	50559289
Spinal cord haemorrhage	14.94	11.38	6	45077	206	50559835
Therapeutic product effect increased	14.93	11.38	10	45073	1006	50559035
Jugular vein thrombosis	14.88	11.38	15	45068	2681	50557360
Haemoglobin abnormal	14.87	11.38	19	45064	4393	50555648
Type 2 diabetes mellitus	14.85	11.38	6	45077	34369	50525672
Blood creatine increased	14.85	11.38	20	45063	4867	50555174
Heparin-induced thrombocytopenia test	14.78	11.38	3	45080	6	50560035
Vascular parkinsonism	14.72	11.38	5	45078	106	50559935
Spontaneous haematoma	14.68	11.38	9	45074	777	50559264
Infection	14.68	11.38	92	44991	172862	50387179
Threatened labour	14.67	11.38	9	45074	778	50559263
Plantar erythema	14.65	11.38	6	45077	217	50559824
Cytokine release syndrome	14.60	11.38	27	45056	8607	50551434
Agranulocytosis	14.45	11.38	47	45036	21374	50538667
Serratia infection	14.43	11.38	9	45074	801	50559240
Renal haemorrhage	14.42	11.38	9	45074	802	50559239
Electrocardiogram T wave alternans	14.37	11.38	4	45079	42	50559999
Peritonitis	14.30	11.38	38	45045	15448	50544593
International normalised ratio increased	14.26	11.38	76	45007	43076	50516965
Hepatic infarction	14.23	11.38	8	45075	588	50559453
Eosinophil cationic protein increased	14.20	11.38	4	45079	44	50559997
Diarrhoea	14.12	11.38	408	44675	588068	49971973
Adverse event	14.08	11.38	11	45072	43752	50516289
Spinal cord oedema	14.02	11.38	5	45078	123	50559918
Haemorrhagic cerebral infarction	13.99	11.38	8	45075	608	50559433
Balance disorder	13.94	11.38	26	45057	70564	50489477
Melaena	13.89	11.38	54	45029	26810	50533231
Fungal sepsis	13.78	11.38	10	45073	1144	50558897
Injury	13.70	11.38	14	45069	48911	50511130
Mouth ulceration	13.65	11.38	4	45079	28020	50532021
Anticoagulation drug level above therapeutic	13.64	11.38	10	45073	1162	50558879
Pulmonary artery thrombosis	13.62	11.38	8	45075	639	50559402
Breast cancer	13.52	11.38	11	45072	42879	50517162
Enterococcal infection	13.50	11.38	23	45060	6875	50553166
Thrombin time abnormal	13.46	11.38	3	45080	11	50560030
Tachycardia	13.45	11.38	142	44941	99621	50460420
Device related sepsis	13.38	11.38	16	45067	3459	50556582
Fistula discharge	13.21	11.38	9	45074	931	50559110
Stoma site haemorrhage	13.20	11.38	9	45074	932	50559109
Pulmonary haemorrhage	13.18	11.38	22	45061	6470	50553571
Eschar	13.16	11.38	7	45076	461	50559580
Adverse drug reaction	13.11	11.38	18	45065	55204	50504837
Rhinorrhoea	13.08	11.38	16	45067	51567	50508474
Cardiac ventricular thrombosis	12.91	11.38	7	45076	479	50559562
Hypovolaemia	12.86	11.38	27	45056	9438	50550603
Subdural haemorrhage	12.86	11.38	14	45069	2735	50557306
Pulmonary oedema	12.79	11.38	81	45002	48857	50511184
Coronary artery dissection	12.76	11.38	8	45075	719	50559322
Seizure like phenomena	12.72	11.38	9	45074	989	50559052
Cataract	12.72	11.38	14	45069	47286	50512755
Haematidrosis	12.71	11.38	4	45079	66	50559975
Dry mouth	12.66	11.38	19	45064	56159	50503882
Ventricular enlargement	12.65	11.38	4	45079	67	50559974
Leg amputation	12.60	11.38	12	45071	2001	50558040
Peritonitis bacterial	12.56	11.38	18	45065	4643	50555398
Blood creatinine increased	12.51	11.38	113	44970	76047	50483994
Arterial rupture	12.41	11.38	6	45077	323	50559718
Anxiety	12.38	11.38	100	44983	177506	50382535
Haemorrhagic stroke	12.37	11.38	19	45064	5209	50554832
Wound haematoma	12.33	11.38	4	45079	73	50559968
Sleep disorder	12.31	11.38	20	45063	57263	50502778
Abortion early	12.25	11.38	3	45080	18	50560023
Pulse waveform abnormal	12.18	11.38	4	45079	76	50559965
Ischaemia	12.17	11.38	17	45066	4280	50555761
Muscle spasms	12.15	11.38	64	45019	125489	50434552
Ankle brachial index decreased	12.13	11.38	4	45079	77	50559964
Basal ganglia haemorrhage	12.11	11.38	7	45076	543	50559498
Clostridium difficile colitis	12.04	11.38	39	45044	17703	50542338
Central venous catheterisation	12.03	11.38	12	45071	2118	50557923
Fall	12.03	11.38	218	44865	334714	50225327
Colorectal cancer	12.02	11.38	10	45073	1397	50558644
Adrenomegaly	11.98	11.38	3	45080	20	50560021
Limbal swelling	11.98	11.38	3	45080	20	50560021
Blood loss anaemia	11.98	11.38	24	45059	8115	50551926
Carotid intima-media thickness increased	11.94	11.38	4	45079	81	50559960
Procedural hypotension	11.92	11.38	9	45074	1093	50558948
Cytomegalovirus enterocolitis	11.89	11.38	7	45076	562	50559479
Adenocarcinoma of colon	11.88	11.38	12	45071	2150	50557891
Breast haematoma	11.85	11.38	5	45078	195	50559846
Toxic skin eruption	11.84	11.38	29	45054	11222	50548819
Splenic haemorrhage	11.83	11.38	5	45078	196	50559845
Gastrointestinal necrosis	11.75	11.38	13	45070	2585	50557456
Blister	11.73	11.38	38	45045	85380	50474661
Drug-device interaction	11.72	11.38	4	45079	86	50559955
Toxic encephalopathy	11.61	11.38	19	45064	5496	50554545
Epistaxis	11.61	11.38	97	44986	63857	50496184
Cerebral artery occlusion	11.53	11.38	8	45075	852	50559189
Atrial fibrillation	11.53	11.38	140	44943	101605	50458436
Renal artery thrombosis	11.47	11.38	4	45079	92	50559949
Bleeding time prolonged	11.47	11.38	7	45076	600	50559441
COVID-19 pneumonia	11.47	11.38	24	45059	8371	50551670
Acute pulmonary oedema	11.39	11.38	22	45061	7245	50552796

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heparin-induced thrombocytopenia	2894.06	12.30	792	44830	4187	29524718
Vascular stent thrombosis	336.38	12.30	133	45489	2477	29526428
Thrombocytopenia	248.58	12.30	603	45019	134220	29394685
Labelled drug-drug interaction medication error	217.14	12.30	167	45455	11992	29516913
Haematoma	206.55	12.30	215	45407	22997	29505908
Haemorrhage	175.89	12.30	277	45345	44795	29484110
Cardiogenic shock	162.25	12.30	173	45449	19017	29509888
Post procedural haemorrhage	151.79	12.30	111	45511	7380	29521525
Shock haemorrhagic	142.36	12.30	118	45504	9433	29519472
Haemorrhage intracranial	138.94	12.30	140	45482	14402	29514503
Cerebral haemorrhage	137.89	12.30	204	45418	31222	29497683
Multiple organ dysfunction syndrome	132.04	12.30	297	45325	62819	29466086
Thrombosis	129.99	12.30	236	45386	42809	29486096
Retroperitoneal haematoma	126.08	12.30	65	45557	2293	29526612
Thrombosis in device	124.02	12.30	71	45551	3093	29525812
Fatigue	118.32	12.30	192	45430	316629	29212276
Appendicolith	117.75	12.30	71	45551	3409	29525496
Coagulation time shortened	113.98	12.30	32	45590	187	29528718
Cardiac tamponade	113.21	12.30	77	45545	4558	29524347
Ventricular fibrillation	103.63	12.30	125	45497	15708	29513197
Heparin resistance	103.13	12.30	21	45601	16	29528889
Arterial thrombosis	96.01	12.30	46	45576	1382	29527523
Drug abuse	93.50	12.30	8	45614	79875	29449030
Septic shock	91.51	12.30	257	45365	62303	29466602
Activated partial thromboplastin time prolonged	89.91	12.30	83	45539	7659	29521246
Pulmonary embolism	89.00	12.30	290	45332	76244	29452661
Brain herniation	85.52	12.30	59	45563	3574	29525331
Appendicitis	84.73	12.30	85	45537	8694	29520211
Off label use	83.00	12.30	766	44856	300034	29228871
Arthralgia	82.88	12.30	57	45565	139560	29389345
Drug reaction with eosinophilia and systemic symptoms	82.60	12.30	152	45470	27840	29501065
Heparin-induced thrombocytopenia test positive	79.43	12.30	21	45601	94	29528811
Subarachnoid haemorrhage	75.99	12.30	84	45538	9608	29519297
Weight decreased	74.26	12.30	74	45548	150831	29378074
Depression	73.84	12.30	20	45602	85127	29443778
Toxicity to various agents	72.67	12.30	97	45525	173564	29355341
Eosinophilia	72.64	12.30	126	45496	22035	29506870
Coagulation time prolonged	72.42	12.30	36	45586	1174	29527731
Intraventricular haemorrhage	70.31	12.30	48	45574	2858	29526047
Retroperitoneal haemorrhage	69.06	12.30	45	45577	2478	29526427
Death	66.55	12.30	287	45335	341797	29187108
Coagulation time	65.71	12.30	12	45610	0	29528905
Low birth weight baby	63.80	12.30	64	45558	6544	29522361
Sepsis	63.06	12.30	406	45216	142276	29386629
Intra-abdominal haemorrhage	61.38	12.30	39	45583	2056	29526849
Disseminated intravascular coagulation	60.84	12.30	110	45512	19870	29509035
Cardiac arrest	60.51	12.30	277	45345	85314	29443591
Premature baby	60.26	12.30	101	45521	17179	29511726
Haematoma muscle	58.84	12.30	29	45593	928	29527977
Compartment syndrome	58.14	12.30	40	45582	2412	29526493
Muscle haemorrhage	57.43	12.30	45	45577	3317	29525588
Rash maculo-papular	57.22	12.30	120	45502	24169	29504736
Deep vein thrombosis	56.64	12.30	206	45416	57193	29471712
Product administration error	55.82	12.30	88	45534	14222	29514683
Haemoglobin decreased	55.20	12.30	320	45302	108055	29420850
Catheter site haemorrhage	54.77	12.30	36	45586	2012	29526893
Diarrhoea	54.29	12.30	297	45325	332401	29196504
Venous thrombosis	54.27	12.30	42	45580	3040	29525865
Fall	53.98	12.30	121	45501	177057	29351848
Acute kidney injury	52.03	12.30	631	44991	264636	29264269
Asthenia	51.27	12.30	166	45456	215084	29313821
Product use in unapproved indication	50.56	12.30	266	45356	86609	29442296
Hypotension	50.43	12.30	489	45133	193865	29335040
Haemodynamic instability	50.00	12.30	62	45560	8011	29520894
Pericardial haemorrhage	49.57	12.30	39	45583	2892	29526013
Procedural haemorrhage	48.91	12.30	35	45587	2248	29526657
Intentional overdose	47.51	12.30	3	45619	38525	29490380
Coagulation time abnormal	47.23	12.30	15	45607	141	29528764
Pharyngeal haemorrhage	46.35	12.30	22	45600	647	29528258
Haemothorax	46.16	12.30	40	45582	3396	29525509
Coagulation test abnormal	45.92	12.30	20	45602	479	29528426
Acute respiratory distress syndrome	45.75	12.30	106	45516	22829	29506076
Cardiac ventricular thrombosis	44.83	12.30	24	45598	915	29527990
Pulmonary haemorrhage	44.75	12.30	63	45559	9207	29519698
Ventricular tachycardia	44.66	12.30	104	45518	22470	29506435
Decreased appetite	44.45	12.30	99	45523	145243	29383662
Insomnia	44.22	12.30	43	45579	88718	29440187
Pulseless electrical activity	44.07	12.30	52	45570	6382	29522523
Cerebral infarction	42.75	12.30	108	45514	24567	29504338
Lymphocyte count decreased	41.70	12.30	92	45530	19179	29509726
Product measured potency issue	41.65	12.30	12	45610	78	29528827
Dizziness	41.27	12.30	152	45470	189532	29339373
Skin necrosis	40.26	12.30	44	45578	4968	29523937
Incision site pain	39.73	12.30	28	45594	1755	29527150
Pain	39.54	12.30	134	45488	171298	29357607
Kounis syndrome	39.09	12.30	28	45594	1801	29527104
Coronary artery thrombosis	39.01	12.30	29	45593	1976	29526929
Hypertransaminasaemia	38.68	12.30	37	45585	3569	29525336
Weight increased	38.35	12.30	37	45585	76630	29452275
Product dose omission issue	38.09	12.30	56	45566	96327	29432578
Hereditary angioedema	37.89	12.30	20	45602	741	29528164
Peripheral artery thrombosis	37.54	12.30	29	45593	2093	29526812
Malaise	37.32	12.30	124	45498	159478	29369427
Choroidal infarction	36.76	12.30	11	45611	83	29528822
Suspected product quality issue	36.18	12.30	12	45610	131	29528774
Adrenal haemorrhage	36.01	12.30	13	45609	186	29528719
Coagulopathy	35.97	12.30	83	45539	17824	29511081
Psoriasis	35.66	12.30	4	45618	32223	29496682
Therapeutic product effect decreased	35.45	12.30	113	45509	29338	29499567
Muscle spasms	35.44	12.30	29	45593	65053	29463852
Product quality issue	34.52	12.30	76	45546	15819	29513086
Respiratory failure	34.38	12.30	262	45360	96869	29432036
Musculoskeletal stiffness	33.99	12.30	8	45614	37450	29491455
Aggression	33.44	12.30	7	45615	35534	29493371
Cerebral venous sinus thrombosis	33.41	12.30	15	45607	387	29528518
Pulmonary alveolar haemorrhage	33.26	12.30	45	45577	6335	29522570
Intestinal ischaemia	33.07	12.30	46	45576	6646	29522259
Gait disturbance	32.67	12.30	39	45583	73310	29455595
Haemorrhagic infarction	32.44	12.30	15	45607	415	29528490
Pulmonary haematoma	32.44	12.30	9	45613	50	29528855
Myalgia	32.29	12.30	40	45582	73979	29454926
Red blood cells urine positive	32.11	12.30	24	45598	1649	29527256
Haematuria	32.01	12.30	144	45478	43995	29484910
Puncture site haemorrhage	31.65	12.30	13	45609	268	29528637
Intracardiac thrombus	31.40	12.30	27	45595	2268	29526637
Aortic thrombosis	31.38	12.30	17	45605	664	29528241
Asthma	31.17	12.30	7	45615	33842	29495063
Vascular stent occlusion	31.08	12.30	11	45611	148	29528757
Memory impairment	30.79	12.30	9	45613	36461	29492444
Heparin-induced thrombocytopenia test	30.58	12.30	10	45612	104	29528801
Dehydration	30.49	12.30	84	45538	114664	29414241
Atrial thrombosis	30.47	12.30	25	45597	1968	29526937
Burkholderia test positive	30.27	12.30	19	45603	980	29527925
Renal infarct	30.12	12.30	20	45602	1137	29527768
Arterial haemorrhage	29.97	12.30	17	45605	727	29528178
Vasodilatation	29.84	12.30	19	45603	1005	29527900
Cerebral reperfusion injury	29.80	12.30	6	45616	4	29528901
Stress	29.16	12.30	86	45536	21404	29507501
Embolism	29.12	12.30	44	45578	6852	29522053
Reperfusion injury	29.09	12.30	9	45613	77	29528828
Cerebral hyperperfusion syndrome	28.99	12.30	9	45613	78	29528827
Balance disorder	28.63	12.30	10	45612	36160	29492745
Brain oedema	28.34	12.30	60	45562	12160	29516745
Drug intolerance	28.33	12.30	20	45602	48359	29480546
Coronary artery perforation	28.04	12.30	8	45614	50	29528855
Chest wall haematoma	27.70	12.30	10	45612	143	29528762
Cardiac procedure complication	27.33	12.30	10	45612	149	29528756
Product contamination	27.27	12.30	15	45607	604	29528301
Electrocardiogram ST segment elevation	27.02	12.30	34	45588	4458	29524447
Device related thrombosis	26.50	12.30	17	45605	911	29527994
Tongue haematoma	26.07	12.30	9	45613	112	29528793
Peripheral artery occlusion	25.91	12.30	20	45602	1442	29527463
Anticoagulation drug level below therapeutic	25.85	12.30	15	45607	670	29528235
Spinal epidural haematoma	25.83	12.30	11	45611	249	29528656
Haemorrhagic transformation stroke	25.65	12.30	19	45603	1287	29527618
Neuropathy peripheral	25.47	12.30	44	45578	70983	29457922
Blood urea increased	25.30	12.30	98	45524	28014	29500891
Prosthetic cardiac valve thrombosis	25.08	12.30	6	45616	16	29528889
Ischaemic hepatitis	24.90	12.30	20	45602	1528	29527377
Aneurysm ruptured	24.89	12.30	13	45609	471	29528434
Somnolence	24.79	12.30	69	45553	93886	29435019
Aortic dissection	24.70	12.30	24	45598	2360	29526545
Acute myocardial infarction	24.59	12.30	143	45479	48295	29480610
Acute respiratory failure	24.55	12.30	93	45529	26309	29502596
Haemoperitoneum	24.52	12.30	20	45602	1562	29527343
Jugular vein thrombosis	24.48	12.30	19	45603	1381	29527524
Injection site pain	23.96	12.30	10	45612	32436	29496469
Leukocytosis	23.53	12.30	79	45543	21063	29507842
Agitation	23.14	12.30	27	45595	51277	29477628
Arthropathy	23.04	12.30	3	45619	21551	29507354
Gastrointestinal haemorrhage	23.00	12.30	205	45417	79328	29449577
Subdural haematoma	22.99	12.30	71	45551	18122	29510783
Abdominal discomfort	22.93	12.30	24	45598	47879	29481026
Vascular pseudoaneurysm	22.83	12.30	21	45601	1928	29526977
Embolic stroke	22.82	12.30	28	45594	3578	29525327
Vena cava thrombosis	22.71	12.30	16	45606	1002	29527903
Cerebral mass effect	22.38	12.30	15	45607	866	29528039
Pain in extremity	22.37	12.30	91	45531	110342	29418563
Acute right ventricular failure	22.25	12.30	8	45614	113	29528792
Haemorrhagic cerebral infarction	22.19	12.30	14	45608	729	29528176
Feeling abnormal	22.12	12.30	31	45591	54414	29474491
Rash morbilliform	21.99	12.30	23	45599	2470	29526435
Suspected transmission of an infectious agent via product	21.82	12.30	13	45609	610	29528295
Hypercoagulation	21.70	12.30	16	45606	1076	29527829
Gastrointestinal necrosis	21.65	12.30	25	45597	2997	29525908
Dyspnoea exertional	21.47	12.30	15	45607	36475	29492430
Haemorrhagic stroke	21.45	12.30	35	45587	5821	29523084
Rash	21.19	12.30	189	45433	189630	29339275
Antiphospholipid syndrome	20.95	12.30	11	45611	403	29528502
Peripheral ischaemia	20.68	12.30	32	45590	5087	29523818
Incorrect drug administration rate	20.65	12.30	16	45606	1160	29527745
Activated partial thromboplastin time shortened	20.53	12.30	11	45611	420	29528485
Dyspnoea	20.48	12.30	368	45254	326364	29202541
Foetal growth restriction	20.30	12.30	27	45595	3739	29525166
Dysgeusia	20.26	12.30	5	45617	22669	29506236
Foetal exposure timing unspecified	20.23	12.30	9	45613	227	29528678
Loss of personal independence in daily activities	20.19	12.30	7	45615	25433	29503472
Drug hypersensitivity	20.13	12.30	177	45445	68229	29460676
Mixed liver injury	20.05	12.30	20	45602	2031	29526874
Overdose	20.04	12.30	60	45562	79759	29449146
Neutrophil count increased	20.00	12.30	59	45563	14683	29514222
Peripheral swelling	19.79	12.30	43	45579	63696	29465209
Unresponsive to stimuli	19.75	12.30	84	45538	25042	29503863
Livedo reticularis	19.75	12.30	20	45602	2068	29526837
Hemiplegia	19.68	12.30	36	45586	6558	29522347
Respiratory tract oedema	19.68	12.30	10	45612	342	29528563
Arthritis	19.66	12.30	7	45615	25012	29503893
Alopecia	19.60	12.30	3	45619	19081	29509824
Herpes zoster	19.55	12.30	11	45611	30041	29498864
Toxic epidermal necrolysis	19.47	12.30	67	45555	18086	29510819
Anxiety	19.46	12.30	67	45555	85298	29443607
Oedema peripheral	19.33	12.30	88	45534	103469	29425436
Peliosis hepatis	19.32	12.30	6	45616	52	29528853
Extradural haematoma	19.32	12.30	15	45607	1091	29527814
Graft thrombosis	19.24	12.30	9	45613	256	29528649
Psychotic disorder	19.17	12.30	4	45618	20350	29508555
Mediastinal haematoma	19.15	12.30	7	45615	104	29528801
Epistaxis	19.14	12.30	141	45481	51563	29477342
Sleep disorder	18.86	12.30	7	45615	24379	29504526
Intrapericardial thrombosis	18.84	12.30	6	45616	57	29528848
Shock	18.76	12.30	74	45548	21330	29507575
Nasopharyngitis	18.74	12.30	40	45582	59625	29469280
Vascular access site haematoma	18.67	12.30	4	45618	5	29528900
Medical device site thrombosis	18.30	12.30	5	45617	26	29528879
Bronchial haemorrhage	18.25	12.30	12	45610	671	29528234
Osteoarthritis	18.24	12.30	3	45619	18100	29510805
Anticoagulation drug level above therapeutic	18.16	12.30	18	45604	1813	29527092
Haemoptysis	18.05	12.30	94	45528	30456	29498449
Ischaemic stroke	18.04	12.30	60	45562	15917	29512988
Hypoxia	17.99	12.30	130	45492	47249	29481656
Cognitive disorder	17.75	12.30	7	45615	23492	29505413
Gastric haemorrhage	17.48	12.30	42	45580	9255	29519650
Subcutaneous haematoma	17.42	12.30	13	45609	891	29528014
Therapeutic product ineffective	17.39	12.30	11	45611	575	29528330
Vertigo	17.37	12.30	6	45616	21855	29507050
Diabetes insipidus	17.21	12.30	20	45602	2414	29526491
Thrombotic microangiopathy	17.17	12.30	40	45582	8641	29520264
Pancreatic haemorrhage	17.16	12.30	5	45617	34	29528871
Protein urine present	17.11	12.30	28	45594	4666	29524239
Prostate cancer	17.10	12.30	9	45613	25518	29503387
Pulmonary artery thrombosis	16.91	12.30	11	45611	604	29528301
Abdominal distension	16.87	12.30	125	45497	45786	29483119
Malignant neoplasm progression	16.81	12.30	58	45564	73801	29455104
Mean cell haemoglobin concentration	16.80	12.30	5	45617	37	29528868
Platelet disorder	16.65	12.30	15	45607	1340	29527565
Vascular access site haemorrhage	16.63	12.30	4	45618	11	29528894
Visual impairment	16.46	12.30	13	45609	29695	29499210
Anisochromia	16.43	12.30	3	45619	0	29528905
Acquired antithrombin III deficiency	16.43	12.30	3	45619	0	29528905
Procedural pain	16.41	12.30	26	45596	4218	29524687
Ventricular asystole	16.33	12.30	7	45615	161	29528744
Irritability	16.08	12.30	7	45615	22145	29506760
Dermatitis bullous	16.08	12.30	31	45591	5875	29523030
Blood loss anaemia	16.07	12.30	35	45587	7231	29521674
Cough	16.03	12.30	122	45500	126605	29402300
Blood pressure decreased	15.69	12.30	122	45500	45355	29483550
Neonatal respiratory distress syndrome	15.65	12.30	24	45598	3786	29525119
Treatment noncompliance	15.57	12.30	9	45613	24218	29504687
Urea renal clearance decreased	15.49	12.30	4	45618	16	29528889
Head injury	15.47	12.30	3	45619	16078	29512827
Hypovolaemic shock	15.47	12.30	31	45591	6041	29522864
Renal haemorrhage	15.44	12.30	14	45608	1262	29527643
Nutritional condition abnormal	15.33	12.30	9	45613	411	29528494
Tachycardia	15.31	12.30	175	45447	72235	29456670
Rhinorrhoea	15.31	12.30	7	45615	21512	29507393
Confusional state	15.29	12.30	125	45497	127752	29401153
Gangrene	15.16	12.30	25	45597	4193	29524712
Melaena	15.15	12.30	91	45531	31085	29497820
Respiratory distress	15.15	12.30	93	45529	32013	29496892
Ventricular extrasystoles	14.98	12.30	43	45579	10539	29518366
Hepatic infarction	14.96	12.30	7	45615	199	29528706
Cerebral haematoma	14.82	12.30	25	45597	4271	29524634
COVID-19 pneumonia	14.77	12.30	40	45582	9482	29519423
Alveolitis necrotising	14.77	12.30	4	45618	20	29528885
Retinal pigment epitheliopathy	14.71	12.30	7	45615	207	29528698
Basal cell carcinoma	14.59	12.30	4	45618	16906	29511999
Splenic infarction	14.52	12.30	16	45606	1823	29527082
Bronchopulmonary aspergillosis	14.52	12.30	47	45575	12297	29516608
Myiasis	14.45	12.30	4	45618	22	29528883
Reperfusion arrhythmia	14.36	12.30	5	45617	64	29528841
Autoimmune heparin-induced thrombocytopenia	14.35	12.30	3	45619	3	29528902
Bullous haemorrhagic dermatosis	14.35	12.30	3	45619	3	29528902
Intra-abdominal haematoma	14.34	12.30	13	45609	1171	29527734
Distributive shock	14.32	12.30	12	45610	973	29527932
Vision blurred	14.29	12.30	25	45597	40151	29488754
Fungal sepsis	14.19	12.30	11	45611	798	29528107
Haemorrhagic cholecystitis	14.08	12.30	5	45617	68	29528837
Upper gastrointestinal haemorrhage	14.05	12.30	69	45553	21845	29507060
Monoplegia	13.97	12.30	14	45608	1429	29527476
Hot flush	13.84	12.30	3	45619	14867	29514038
Gastrooesophageal reflux disease	13.75	12.30	17	45605	31479	29497426
Wrong technique in product usage process	13.68	12.30	17	45605	31411	29497494
Microangiopathic haemolytic anaemia	13.65	12.30	11	45611	844	29528061
Complications of transplanted kidney	13.63	12.30	23	45599	3931	29524974
Inferior vena caval occlusion	13.63	12.30	4	45618	28	29528877
Necrotising oesophagitis	13.53	12.30	9	45613	513	29528392
Coronary artery aneurysm	13.45	12.30	5	45617	78	29528827
Encephalopathy	13.45	12.30	88	45534	30955	29497950
Tremor	13.42	12.30	63	45559	73475	29455430
Full blood count decreased	13.40	12.30	4	45618	15988	29512917
Primary adrenal insufficiency	13.39	12.30	4	45618	30	29528875
Apgar score abnormal	13.39	12.30	4	45618	30	29528875
Blood pressure fluctuation	13.35	12.30	7	45615	19887	29509018
Catheter site haematoma	13.32	12.30	6	45616	156	29528749
Influenza	13.21	12.30	28	45594	41853	29487052
Vascular graft thrombosis	13.18	12.30	6	45616	160	29528745
Microstomia	13.14	12.30	3	45619	6	29528899
Paraesthesia	13.14	12.30	41	45581	53804	29475101
Aplastic anaemia	13.13	12.30	33	45589	7477	29521428
Basophil count decreased	13.06	12.30	5	45617	85	29528820
Platelet transfusion	13.04	12.30	12	45610	1102	29527803
Syncope	12.99	12.30	73	45549	81298	29447607
Soft tissue necrosis	12.93	12.30	7	45615	273	29528632
Cytokine release syndrome	12.85	12.30	47	45575	13072	29515833
Road traffic accident	12.84	12.30	4	45618	15557	29513348
Disease progression	12.80	12.30	74	45548	81842	29447063
White blood cell count decreased	12.65	12.30	76	45546	83286	29445619
Hemiparesis	12.62	12.30	50	45572	14436	29514469
Renal artery thrombosis	12.59	12.30	7	45615	288	29528617
Lumbar puncture	12.55	12.30	5	45617	95	29528810
Incision site haematoma	12.55	12.30	5	45617	95	29528810
Anti factor Xa activity decreased	12.54	12.30	3	45619	8	29528897
Torsade de pointes	12.42	12.30	30	45592	6631	29522274
Orthostatic hypotension	12.41	12.30	10	45612	22619	29506286
Hallucination	12.41	12.30	32	45590	44680	29484225
Respiratory gas exchange disorder	12.40	12.30	8	45614	433	29528472
Alanine aminotransferase decreased	12.36	12.30	10	45612	772	29528133
Osteonecrosis of jaw	12.33	12.30	5	45617	16505	29512400
Haemobilia	12.31	12.30	7	45615	301	29528604

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heparin-induced thrombocytopenia	5007.80	10.96	1308	79562	7171	64410691
Vascular stent thrombosis	507.59	10.96	182	80688	3182	64414680
Thrombocytopenia	462.77	10.96	926	79944	222875	64194987
Labelled drug-drug interaction medication error	382.34	10.96	274	80596	21788	64396074
Haemorrhage	352.33	10.96	465	80405	78886	64338976
Shock haemorrhagic	348.46	10.96	233	80637	16558	64401304
Haematoma	318.07	10.96	339	80531	45911	64371951
Cerebral haemorrhage	267.29	10.96	325	80545	50765	64367097
Retroperitoneal haematoma	262.52	10.96	125	80745	4586	64413276
Completed suicide	252.76	10.96	6	80864	224408	64193454
Cardiogenic shock	252.30	10.96	254	80616	32173	64385689
Haemorrhage intracranial	250.90	10.96	221	80649	23663	64394199
Thrombosis	240.91	10.96	365	80505	70277	64347585
Pulmonary embolism	240.27	10.96	552	80318	145804	64272058
Premature delivery	236.36	10.96	192	80678	18397	64399465
Multiple organ dysfunction syndrome	235.21	10.96	441	80429	100972	64316890
Thrombosis in device	218.60	10.96	113	80757	4958	64412904
Retroperitoneal haemorrhage	217.14	10.96	111	80759	4757	64413105
Arthralgia	216.06	10.96	145	80725	442115	63975747
Fatigue	188.37	10.96	413	80457	748317	63669545
Joint swelling	188.33	10.96	24	80846	215358	64202504
Rheumatoid arthritis	179.03	10.96	6	80864	164288	64253574
Activated partial thromboplastin time prolonged	174.77	10.96	138	80732	12693	64405169
Pain	171.18	10.96	269	80601	553242	63864620
Cardiac tamponade	168.67	10.96	113	80757	8051	64409811
Post procedural haemorrhage	167.82	10.96	133	80737	12298	64405564
Acute kidney injury	166.79	10.96	1047	79823	448193	63969669
Drug intolerance	146.21	10.96	29	80841	187963	64229899
Coagulation time shortened	145.96	10.96	42	80828	344	64417518
Maternal exposure during pregnancy	144.56	10.96	350	80520	95534	64322328
Cerebral infarction	144.03	10.96	215	80655	40829	64377033
Haemothorax	137.57	10.96	82	80788	4760	64413102
Cardiac arrest	137.12	10.96	465	80405	153599	64264263
Sepsis	137.05	10.96	612	80258	229729	64188133
Off label use	132.45	10.96	1291	79579	631515	63786347
Appendicolith	131.65	10.96	71	80799	3398	64414464
Haematoma muscle	129.55	10.96	57	80813	1736	64416126
Brain herniation	126.80	10.96	87	80783	6446	64411416
Ventricular fibrillation	126.71	10.96	153	80717	23707	64394155
Septic shock	126.20	10.96	353	80517	105084	64312778
Abdominal wall haematoma	125.17	10.96	74	80796	4231	64413631
Heparin-induced thrombocytopenia test positive	124.84	10.96	30	80840	108	64417754
Compartment syndrome	123.71	10.96	73	80797	4159	64413703
Exposure during pregnancy	122.96	10.96	289	80581	77386	64340476
Drug abuse	122.60	10.96	12	80858	132362	64285500
Deep vein thrombosis	120.87	10.96	347	80523	104835	64313027
Arthropathy	120.26	10.96	8	80862	120959	64296903
Arterial thrombosis	118.91	10.96	59	80811	2371	64415491
Subarachnoid haemorrhage	117.69	10.96	130	80740	18308	64399554
Eosinophilia	117.55	10.96	188	80682	37888	64379974
Haemoglobin decreased	117.29	10.96	520	80350	194543	64223319
Heparin resistance	116.34	10.96	23	80847	20	64417842
Product use in unapproved indication	116.31	10.96	484	80386	176134	64241728
Alopecia	116.08	10.96	32	80838	165658	64252204
Vascular pseudoaneurysm	115.94	10.96	63	80807	3061	64414801
Toxicity to various agents	114.72	10.96	174	80696	363339	64054523
Coagulation time prolonged	113.67	10.96	55	80815	2091	64415771
Pharyngeal haemorrhage	112.77	10.96	46	80824	1156	64416706
Disseminated intravascular coagulation	111.42	10.96	168	80702	32180	64385682
Muscle haemorrhage	105.52	10.96	74	80796	5679	64412183
Extradural haematoma	105.00	10.96	56	80814	2620	64415242
Haemoperitoneum	100.17	10.96	62	80808	3853	64414009
Respiratory failure	98.61	10.96	432	80438	160751	64257111
Hereditary angioedema	98.20	10.96	61	80809	3815	64414047
Spinal epidural haematoma	97.95	10.96	42	80828	1200	64416662
Drug reaction with eosinophilia and systemic symptoms	97.24	10.96	212	80658	54005	64363857
Procedural haemorrhage	95.47	10.96	62	80808	4190	64413672
Venous thrombosis	92.03	10.96	71	80799	6310	64411552
Hypotension	91.39	10.96	801	80069	380173	64037689
Abdominal discomfort	91.23	10.96	58	80812	182264	64235598
Nasopharyngitis	89.37	10.96	69	80801	196004	64221858
Weight increased	88.76	10.96	82	80788	213266	64204596
Malaise	88.59	10.96	232	80638	396015	64021847
Rash maculo-papular	87.90	10.96	187	80683	46839	64371023
Coronary artery thrombosis	87.85	10.96	51	80819	2818	64415044
Intentional overdose	86.39	10.96	7	80863	89937	64327925
Catheter site haemorrhage	84.08	10.96	59	80811	4532	64413330
Choroidal infarction	83.21	10.96	23	80847	160	64417702
Dizziness	82.28	10.96	271	80599	429892	63987970
Intraventricular haemorrhage	82.24	10.96	56	80814	4097	64413765
Intracardiac thrombus	82.13	10.96	54	80816	3727	64414135
Appendicitis	82.02	10.96	93	80777	13476	64404386
Product administration error	81.93	10.96	134	80736	27509	64390353
Weight decreased	80.59	10.96	147	80723	285592	64132270
Depression	80.40	10.96	67	80803	183224	64234638
Pericardial haemorrhage	80.08	10.96	55	80815	4081	64413781
Skin necrosis	79.55	10.96	94	80776	14235	64403627
Fall	78.07	10.96	265	80605	416561	64001301
Intra-abdominal haemorrhage	76.62	10.96	53	80817	3978	64413884
Adrenal haemorrhage	75.72	10.96	28	80842	536	64417326
Toxic epidermal necrolysis	75.56	10.96	153	80717	37013	64380849
Coagulopathy	75.39	10.96	140	80730	31780	64386082
Peripheral artery thrombosis	75.25	10.96	47	80823	2968	64414894
Subdural haematoma	75.17	10.96	130	80740	27924	64389938
Embolism	74.20	10.96	84	80786	12151	64405711
Pulmonary alveolar haemorrhage	73.38	10.96	75	80795	9663	64408199
Acute myocardial infarction	71.50	10.96	221	80649	69497	64348365
Coagulation time	71.18	10.96	13	80857	3	64417859
Musculoskeletal stiffness	70.63	10.96	33	80837	123173	64294689
Aplastic anaemia	70.24	10.96	87	80783	13833	64404029
Gait disturbance	69.44	10.96	68	80802	172087	64245775
Injection site pain	68.39	10.96	27	80843	111381	64306481
Peripheral ischaemia	67.67	10.96	67	80803	8311	64409551
Diarrhoea	67.13	10.96	582	80288	722122	63695740
Arthritis	67.10	10.96	12	80858	83802	64334060
Haemodynamic instability	67.04	10.96	88	80782	14824	64403038
Insomnia	66.96	10.96	90	80780	197746	64220116
Pulseless electrical activity	66.51	10.96	81	80789	12658	64405204
Psoriasis	65.08	10.96	7	80863	71696	64346166
Acute respiratory distress syndrome	65.03	10.96	148	80722	38787	64379075
Suicidal ideation	64.40	10.96	5	80865	66537	64351325
Suicide attempt	64.27	10.96	7	80863	71000	64346862
Gastrointestinal haemorrhage	63.71	10.96	331	80539	131981	64285881
Pemphigus	63.44	10.96	3	80867	60698	64357164
Haematuria	63.23	10.96	193	80677	60278	64357584
Product dose omission issue	61.55	10.96	93	80777	194654	64223208
Haemorrhagic transformation stroke	61.54	10.96	38	80832	2351	64415511
Hypoxia	61.46	10.96	246	80624	87903	64329959
Coagulation time abnormal	61.11	10.96	19	80851	208	64417654
Aortic thrombosis	60.30	10.96	32	80838	1482	64416380
Lower respiratory tract infection	59.62	10.96	22	80848	94592	64323270
Cardiac ventricular thrombosis	59.36	10.96	31	80839	1389	64416473
Asthenia	59.10	10.96	306	80564	427738	63990124
Asthma	58.57	10.96	23	80847	95202	64322660
Wound	56.95	10.96	13	80857	76464	64341398
Ventricular tachycardia	56.95	10.96	130	80740	34135	64383727
Peripheral swelling	56.82	10.96	110	80760	209043	64208819
Haemorrhagic infarction	56.12	10.96	24	80846	681	64417181
Pain in extremity	55.12	10.96	195	80675	302890	64114972
Product measured potency issue	54.68	10.96	17	80853	186	64417676
Rash	54.59	10.96	344	80526	458205	63959657
Encephalopathy	54.43	10.96	180	80690	58639	64359223
Systemic lupus erythematosus	54.31	10.96	15	80855	77597	64340265
Vasodilatation	53.45	10.96	38	80832	2980	64414882
Headache	52.41	10.96	419	80451	529048	63888814
Memory impairment	52.20	10.96	21	80849	85661	64332201
Cerebral haematoma	51.72	10.96	54	80816	7131	64410731
Arterial haemorrhage	51.24	10.96	33	80837	2198	64415664
Puncture site haemorrhage	51.14	10.96	21	80849	537	64417325
Blood pressure decreased	51.12	10.96	229	80641	85970	64331892
Pulmonary haemorrhage	50.81	10.96	72	80798	13037	64404825
Vena cava thrombosis	50.04	10.96	34	80836	2478	64415384
Myalgia	49.86	10.96	76	80794	158541	64259321
Feeling abnormal	49.14	10.96	57	80813	133545	64284317
Coronary artery perforation	48.97	10.96	13	80857	76	64417786
Renal infarct	48.91	10.96	33	80837	2378	64415484
Hypercoagulation	48.71	10.96	34	80836	2589	64415273
Atrial thrombosis	48.63	10.96	36	80834	3006	64414856
Thrombotic microangiopathy	48.35	10.96	80	80790	16575	64401287
Incision site pain	48.35	10.96	34	80836	2620	64415242
Mobility decreased	47.66	10.96	24	80846	85816	64332046
Cerebral reperfusion injury	47.29	10.96	10	80860	16	64417846
Gangrene	47.28	10.96	52	80818	7286	64410576
Ischaemic stroke	46.97	10.96	109	80761	28926	64388936
Shock	46.66	10.96	129	80741	38111	64379751
Decreased appetite	46.58	10.96	188	80682	281101	64136761
Electrocardiogram ST segment elevation	46.01	10.96	51	80819	7208	64410654
Subchorionic haematoma	45.89	10.96	13	80857	100	64417762
Suspected product quality issue	45.80	10.96	16	80854	258	64417604
Intestinal ischaemia	45.61	10.96	64	80806	11485	64406377
Acute respiratory failure	45.48	10.96	152	80718	49782	64368080
Loss of personal independence in daily activities	45.39	10.96	17	80853	72437	64345425
Osteoarthritis	44.76	10.96	12	80858	63324	64354538
Mixed liver injury	44.58	10.96	44	80826	5437	64412425
Anaemia	43.77	10.96	692	80178	377988	64039874
Product contamination	43.72	10.96	23	80847	1046	64416816
Respiratory distress	43.05	10.96	154	80716	52177	64365685
Lymphocyte count decreased	42.64	10.96	130	80740	40569	64377293
Heparin-induced thrombocytopenia test	42.17	10.96	13	80857	138	64417724
Muscle spasms	42.03	10.96	70	80800	140953	64276909
Infective aneurysm	42.02	10.96	21	80849	857	64417005
Anticoagulation drug level below therapeutic	41.98	10.96	24	80846	1288	64416574
Anxiety	41.96	10.96	123	80747	202526	64215336
Foetal death	41.67	10.96	44	80826	5886	64411976
Suspected transmission of an infectious agent via product	41.11	10.96	21	80849	898	64416964
Death	41.10	10.96	397	80473	482308	63935554
Peripheral artery occlusion	40.38	10.96	28	80842	2110	64415752
Pulmonary infarction	40.36	10.96	33	80837	3189	64414673
Antiphospholipid syndrome	40.34	10.96	25	80845	1557	64416305
Blood pressure fluctuation	40.29	10.96	8	80862	51863	64365999
Somnolence	39.74	10.96	127	80743	203518	64214344
Orbital compartment syndrome	39.48	10.96	9	80861	24	64417838
Acute motor-sensory axonal neuropathy	39.45	10.96	16	80854	396	64417466
Splenic rupture	39.44	10.96	28	80842	2191	64415671
Balance disorder	38.89	10.96	29	80841	83897	64333965
Swelling	38.70	10.96	90	80780	160128	64257734
Haemoptysis	38.37	10.96	142	80728	48906	64368956
Vascular stent occlusion	38.20	10.96	13	80857	193	64417669
Impaired healing	38.20	10.96	14	80856	60459	64357403
Anti factor Xa activity decreased	38.15	10.96	8	80862	12	64417850
Blood urea increased	38.10	10.96	132	80738	44021	64373841
Injection site swelling	37.62	10.96	4	80866	41349	64376513
Product quality issue	36.83	10.96	101	80769	29698	64388164
Intra-abdominal haematoma	36.66	10.96	28	80842	2451	64415411
Hemiplegia	36.62	10.96	61	80809	12707	64405155
Rhinorrhoea	36.03	10.96	15	80855	59954	64357908
Platelet count decreased	35.22	10.96	343	80527	167368	64250494
Gastrointestinal necrosis	35.01	10.96	37	80833	4955	64412907
Red blood cells urine positive	34.67	10.96	35	80835	4443	64413419
Hypersensitivity	34.62	10.96	128	80742	196324	64221538
Gastrooesophageal reflux disease	34.49	10.96	32	80838	83111	64334751
Haemorrhagic cerebral infarction	34.10	10.96	21	80849	1293	64416569
Pericarditis	33.92	10.96	18	80852	62498	64355364
Splenic infarction	33.91	10.96	30	80840	3227	64414635
Platelet aggregation inhibition	33.87	10.96	11	80859	140	64417722
Hemiparesis	33.83	10.96	98	80772	29729	64388133
Tachypnoea	33.78	10.96	91	80779	26480	64391382
Spinal subdural haematoma	33.60	10.96	12	80858	207	64417655
Injection site erythema	33.41	10.96	24	80846	70776	64347086
Haemorrhagic stroke	33.29	10.96	51	80819	9900	64407962
Oesophageal intramural haematoma	32.80	10.96	10	80860	102	64417760
Blood creatinine increased	32.69	10.96	286	80584	135496	64282366
Hypervolaemia	32.63	10.96	114	80756	38171	64379691
Brain oedema	32.61	10.96	80	80790	21995	64395867
Discomfort	32.53	10.96	32	80838	80846	64337016
Cardiac procedure complication	32.42	10.96	13	80857	312	64417550
Cerebral hyperperfusion syndrome	32.28	10.96	10	80860	108	64417754
Ischaemic hepatitis	32.02	10.96	29	80841	3217	64414645
Medical device site thrombosis	31.87	10.96	8	80862	36	64417826
Ill-defined disorder	31.79	10.96	8	80862	44044	64373818
Jugular vein thrombosis	31.61	10.96	31	80839	3800	64414062
Anticoagulation drug level above therapeutic	31.61	10.96	28	80842	3017	64414845
Sinusitis	31.35	10.96	87	80783	145841	64272021
Intentional product misuse	30.97	10.96	27	80843	72268	64345594
Injection site reaction	30.86	10.96	10	80860	46654	64371208
Melaena	30.79	10.96	141	80729	53407	64364455
Embolic stroke	30.78	10.96	40	80830	6671	64411191
Influenza	30.71	10.96	54	80816	106477	64311385
Ocular retrobulbar haemorrhage	30.67	10.96	10	80860	129	64417733
Hepatic enzyme increased	30.57	10.96	74	80796	129869	64287993
Blood loss anaemia	30.41	10.96	59	80811	13833	64404029
Chest wall haematoma	30.36	10.96	13	80857	370	64417492
Tongue haematoma	29.77	10.96	11	80859	210	64417652
Device related thrombosis	29.63	10.96	23	80847	2062	64415800
Activated partial thromboplastin time shortened	29.60	10.96	16	80854	769	64417093
Cardiac valve replacement complication	29.49	10.96	11	80859	216	64417646
Confusional state	29.44	10.96	199	80671	260945	64156917
Embolic cerebral infarction	29.34	10.96	18	80852	1101	64416761
Therapeutic product effect incomplete	29.33	10.96	53	80817	103429	64314433
Leukocytosis	29.30	10.96	109	80761	37631	64380231
Graft thrombosis	29.09	10.96	13	80857	411	64417451
Back pain	29.02	10.96	189	80681	249982	64167880
Vascular access site haemorrhage	28.96	10.96	7	80863	26	64417836
Neutrophil count increased	28.83	10.96	83	80787	25091	64392771
Bullous haemorrhagic dermatosis	28.65	10.96	8	80862	58	64417804
Hypertransaminasaemia	28.62	10.96	40	80830	7151	64410711
Anti-platelet antibody	28.61	10.96	6	80864	9	64417853
Irritable bowel syndrome	28.53	10.96	6	80864	37363	64380499
Atrial fibrillation	28.49	10.96	334	80536	170755	64247107
Toxoplasmosis	28.46	10.96	24	80846	2420	64415442
Pituitary apoplexy	28.30	10.96	10	80860	167	64417695
Pulmonary haematoma	28.20	10.96	9	80861	108	64417754
Pulmonary artery thrombosis	28.10	10.96	18	80852	1188	64416674
Drug chemical incompatibility	28.08	10.96	8	80862	63	64417799
Rectosigmoid cancer	27.91	10.96	11	80859	252	64417610
Renal failure	27.77	10.96	349	80521	181339	64236523
Spinal cord compression	27.74	10.96	35	80835	5668	64412194
Reperfusion injury	27.56	10.96	10	80860	181	64417681
Acute generalised exanthematous pustulosis	27.54	10.96	57	80813	14001	64403861
Fungal sepsis	27.36	10.96	20	80850	1638	64416224
Procedural hypotension	27.23	10.96	21	80849	1865	64415997
Sleep disorder	27.19	10.96	21	80849	59688	64358174
Cytokine release syndrome	27.15	10.96	72	80798	20757	64397105
Aggression	27.08	10.96	12	80858	46220	64371642
Injection site pruritus	27.04	10.96	7	80863	37819	64380043
Epistaxis	26.98	10.96	213	80657	97918	64319944
Coagulation test abnormal	26.81	10.96	17	80853	1102	64416760
Aortic dissection	26.76	10.96	27	80843	3425	64414437
Blood albumin decreased	26.61	10.96	72	80798	21001	64396861
Renal haemorrhage	26.56	10.96	21	80849	1934	64415928
Hyperkalaemia	26.44	10.96	217	80653	100912	64316950
Hepatic infarction	26.34	10.96	15	80855	799	64417063
Incorrect drug administration rate	26.25	10.96	24	80846	2695	64415167
Oliguria	26.12	10.96	57	80813	14519	64403343
Hepatic haematoma	26.10	10.96	15	80855	813	64417049
Intentional self-injury	25.93	10.96	3	80867	29041	64388821
Paraplegia	25.83	10.96	30	80840	4460	64413402
Prosthetic cardiac valve thrombosis	25.80	10.96	7	80863	45	64417817
Subcapsular renal haematoma	25.75	10.96	14	80856	681	64417181
Diabetes insipidus	25.66	10.96	30	80840	4491	64413371
Basal cell carcinoma	25.60	10.96	4	80866	30834	64387028
Cognitive disorder	25.56	10.96	19	80851	55068	64362794
Psychotic disorder	25.50	10.96	6	80864	34572	64383290
Bronchial haemorrhage	25.45	10.96	17	80853	1205	64416657
Nervous system disorder	25.38	10.96	75	80795	23003	64394859
Cerebral venous sinus thrombosis	25.36	10.96	20	80850	1835	64416027
Premature rupture of membranes	24.93	10.96	27	80843	3717	64414145
Cerebellar haemorrhage	24.92	10.96	23	80847	2614	64415248
Tachycardia	24.89	10.96	292	80578	149287	64268575
Dysgeusia	24.87	10.96	14	80856	47033	64370829
Obstructive shock	24.69	10.96	7	80863	54	64417808
Cerebral mass effect	24.64	10.96	19	80851	1687	64416175
Autoimmune heparin-induced thrombocytopenia	24.48	10.96	5	80865	6	64417856
Abnormal behaviour	24.47	10.96	6	80864	33616	64384246
Sopor	24.28	10.96	4	80866	29657	64388205
Stevens-Johnson syndrome	24.19	10.96	96	80774	34153	64383709
Hydrocephalus	24.13	10.96	38	80832	7553	64410309
Procedural complication	23.98	10.96	37	80833	7228	64410634
Dermatitis bullous	23.76	10.96	49	80821	12005	64405857
Intracranial haematoma	23.70	10.96	14	80856	799	64417063
Platelet transfusion	23.64	10.96	19	80851	1792	64416070
Caesarean section	23.61	10.96	47	80823	11227	64406635
Wrong technique in product usage process	23.58	10.96	28	80842	64946	64352916
Treatment failure	23.37	10.96	72	80798	116744	64301118
Dry mouth	23.05	10.96	25	80845	60393	64357469
Mediastinal haematoma	23.05	10.96	9	80861	201	64417661
Hypovolaemic shock	22.96	10.96	44	80826	10222	64407640
Herpes zoster	22.94	10.96	40	80830	79147	64338715
Aneurysm ruptured	22.93	10.96	14	80856	849	64417013
Arterial intramural haematoma	22.82	10.96	7	80863	73	64417789
Cholestasis	22.79	10.96	114	80756	44758	64373104
Visual impairment	22.78	10.96	36	80834	74041	64343821
Acquired antithrombin III deficiency	22.73	10.96	4	80866	0	64417862
Hot flush	22.70	10.96	15	80855	46220	64371642
Injury	22.69	10.96	22	80848	55970	64361892
Pancreatic haemorrhage	22.57	10.96	7	80863	76	64417786
Ischaemia	22.54	10.96	36	80834	7242	64410620
Device related sepsis	22.52	10.96	30	80840	5125	64412737
COVID-19 pneumonia	22.48	10.96	58	80812	16446	64401416
Infusion related reaction	22.39	10.96	118	80752	164349	64253513
Blood cholesterol increased	22.30	10.96	18	80852	50048	64367814
Drug dependence	22.27	10.96	7	80863	33305	64384557
Kounis syndrome	22.25	10.96	23	80847	3002	64414860
Delayed graft function	22.18	10.96	23	80847	3013	64414849
Renal artery thrombosis	22.17	10.96	11	80859	442	64417420
Unresponsive to stimuli	22.14	10.96	123	80747	50270	64367592
Renal vein thrombosis	22.08	10.96	11	80859	446	64417416
Protein urine present	22.05	10.96	40	80830	8916	64408946
Petechiae	21.90	10.96	62	80808	18564	64399298
Therapeutic product effect increased	21.74	10.96	16	80854	1324	64416538
Peliosis hepatis	21.71	10.96	7	80863	87	64417775
Transcription medication error	21.67	10.96	10	80860	341	64417521
Cerebral artery embolism	21.21	10.96	17	80853	1597	64416265
Gastrointestinal disorder	21.17	10.96	51	80819	89658	64328204
Gastric haemorrhage	21.14	10.96	50	80820	13431	64404431
Cough	21.06	10.96	260	80610	301888	64115974
Retinal pigment epitheliopathy	21.04	10.96	10	80860	365	64417497
Medical device site haemorrhage	20.99	10.96	8	80862	167	64417695
Peritoneal haematoma	20.95	10.96	8	80862	168	64417694
Cataract	20.94	10.96	20	80850	51242	64366620
Dry gangrene	20.90	10.96	13	80857	815	64417047
Contusion	20.89	10.96	73	80797	113892	64303970
Iliac artery occlusion	20.86	10.96	9	80861	261	64417601
Vascular graft occlusion	20.80	10.96	12	80858	655	64417207
Brain death	20.79	10.96	28	80842	4833	64413029
Inflammation	20.78	10.96	31	80839	65269	64352593
Heart rate decreased	20.78	10.96	23	80847	55044	64362818
Toxic skin eruption	20.57	10.96	62	80808	19222	64398640
Normal newborn	20.52	10.96	30	80840	5587	64412275
Mucosal erosion	20.51	10.96	18	80852	1916	64415946
Blood phosphorus increased	20.41	10.96	28	80842	4918	64412944
Dehydration	20.25	10.96	174	80696	216589	64201273
Spontaneous haematoma	20.23	10.96	15	80855	1256	64416606
Intrapericardial thrombosis	20.06	10.96	6	80864	57	64417805
Serratia infection	20.02	10.96	16	80854	1497	64416365
Paratonia	19.83	10.96	5	80865	23	64417839
Post procedural haematoma	19.72	10.96	19	80851	2279	64415583
Type 2 diabetes mellitus	19.66	10.96	9	80861	34011	64383851
Wheezing	19.66	10.96	45	80825	80534	64337328
Protein C decreased	19.61	10.96	6	80864	62	64417800
Immune effector cell-associated neurotoxicity syndrome	19.57	10.96	20	80850	2575	64415287
Ascites	19.54	10.96	139	80731	61862	64356000
Circulatory collapse	19.52	10.96	89	80781	33643	64384219
Dyspepsia	19.47	10.96	45	80825	80267	64337595
Osteonecrosis of jaw	19.45	10.96	13	80857	39812	64378050
Poor quality product administered	19.37	10.96	22	80848	3193	64414669
Vascular graft thrombosis	19.36	10.96	8	80862	208	64417654
Irritability	19.33	10.96	11	80859	36735	64381127
Cerebral amyloid angiopathy	19.32	10.96	9	80861	314	64417548
Dyspnoea	19.31	10.96	722	80148	717952	63699910
Cerebral artery occlusion	19.13	10.96	16	80854	1595	64416267
Aneurysm recanalisation	19.07	10.96	4	80866	6	64417856
Choroidal effusion	19.06	10.96	11	80859	601	64417261
Bleeding time prolonged	18.88	10.96	14	80856	1172	64416690
Infection	18.82	10.96	145	80725	184735	64233127
Pruritus	18.81	10.96	277	80593	312123	64105739
Abdominal compartment syndrome	18.68	10.96	15	80855	1413	64416449
Subcutaneous haematoma	18.48	10.96	19	80851	2464	64415398
Catheter site haematoma	18.48	10.96	9	80861	347	64417515
Abdominal pain upper	18.42	10.96	136	80734	174894	64242968
Tooth disorder	18.38	10.96	3	80867	22399	64395463
Mean cell haemoglobin concentration	18.32	10.96	5	80865	33	64417829
False negative investigation result	18.26	10.96	8	80862	241	64417621
Foetal growth restriction	18.14	10.96	16	80854	1714	64416148
Mouth ulceration	18.11	10.96	9	80861	32435	64385427
Tonsillar haemorrhage	18.08	10.96	8	80862	247	64417615
Live birth	18.05	10.96	42	80828	11162	64406700
Agitation	18.01	10.96	54	80816	88313	64329549
Breast cancer	17.98	10.96	7	80863	29141	64388721
Ventricular asystole	17.90	10.96	8	80862	253	64417609
Dry eye	17.85	10.96	7	80863	29012	64388850
Adverse event	17.84	10.96	14	80856	39475	64378387
Vision blurred	17.83	10.96	56	80814	90260	64327602
Hypernatraemia	17.82	10.96	44	80826	12145	64405717
No adverse event	17.77	10.96	77	80793	28484	64389378
Treatment noncompliance	17.72	10.96	17	80853	43465	64374397
Primary adrenal insufficiency	17.70	10.96	6	80864	88	64417774
Upper gastrointestinal haemorrhage	17.55	10.96	89	80781	35131	64382731
Dysstasia	17.17	10.96	4	80866	23211	64394651
Bronchitis	17.15	10.96	74	80796	108669	64309193
International normalised ratio increased	17.13	10.96	163	80707	79004	64338858
Malignant neoplasm progression	17.08	10.96	78	80792	112793	64305069
Anisochromia	17.05	10.96	3	80867	0	64417862
Acne	17.03	10.96	4	80866	23077	64394785
Fibromyalgia	17.00	10.96	12	80858	35719	64382143
Complications of transplanted kidney	16.99	10.96	27	80843	5408	64412454
Drug withdrawal syndrome	16.99	10.96	9	80861	31282	64386580
Burkholderia test positive	16.96	10.96	10	80860	569	64417293
Cerebral venous thrombosis	16.95	10.96	18	80852	2423	64415439
Red blood cell sedimentation rate increased	16.93	10.96	9	80861	31226	64386636
Livedo reticularis	16.90	10.96	22	80848	3675	64414187
Arterial rupture	16.89	10.96	11	80859	747	64417115
Nausea	16.80	10.96	810	80060	784990	63632872
Depressed mood	16.75	10.96	16	80854	40996	64376866
Rash morbilliform	16.71	10.96	26	80844	5115	64412747
Haemodialysis complication	16.71	10.96	8	80862	297	64417565
Leg amputation	16.62	10.96	21	80849	3406	64414456
Acute right ventricular failure	16.58	10.96	8	80862	302	64417560
Gestational hypertension	16.55	10.96	15	80855	1666	64416196
Thrombin time abnormal	16.52	10.96	4	80866	15	64417847
Osteoporosis	16.52	10.96	17	80853	42063	64375799
Haemoglobin increased	16.48	10.96	26	80844	5175	64412687
White blood cell count decreased	16.44	10.96	123	80747	157714	64260148
Paraesthesia	16.42	10.96	100	80770	134422	64283440
Fibrin D dimer increased	16.38	10.96	30	80840	6735	64411127
Premature labour	16.24	10.96	32	80838	7588	64410274
Enterococcal infection	16.15	10.96	46	80824	13820	64404042
Urea renal clearance decreased	16.12	10.96	4	80866	17	64417845
Pericardial effusion	16.05	10.96	94	80776	39160	64378702
Renal impairment	16.02	10.96	248	80622	134769	64283093
Subclavian vein thrombosis	15.96	10.96	17	80853	2297	64415565
Palpitations	15.93	10.96	72	80798	104416	64313446
Cardiovascular insufficiency	15.88	10.96	18	80852	2606	64415256
Coronary artery aneurysm	15.75	10.96	6	80864	125	64417737
Transfusion	15.70	10.96	54	80816	17940	64399922
Intracranial pressure increased	15.69	10.96	30	80840	6959	64410903
Tremor	15.68	10.96	115	80755	148115	64269747
Stillbirth	15.65	10.96	21	80849	3612	64414250
Alveolitis necrotising	15.59	10.96	4	80866	20	64417842
Haemorrhage subcutaneous	15.51	10.96	23	80847	4338	64413524
Urethral fistula	15.43	10.96	4	80866	21	64417841
Acute pulmonary oedema	15.41	10.96	43	80827	12766	64405096
Alanine aminotransferase decreased	15.35	10.96	13	80857	1319	64416543
Platelet dysfunction	15.35	10.96	8	80862	357	64417505
Incision site haematoma	15.24	10.96	6	80864	137	64417725
HELLP syndrome	15.22	10.96	10	80860	689	64417173
Peritonitis	15.22	10.96	67	80803	24956	64392906
Accidental exposure to product	15.19	10.96	7	80863	26357	64391505
Vertigo	15.18	10.96	32	80838	58979	64358883
Pelvic haematoma	15.17	10.96	10	80860	693	64417169
Coronary artery dissection	15.07	10.96	11	80859	899	64416963
Adverse drug reaction	15.04	10.96	21	80849	45443	64372419
Gastric disorder	14.99	10.96	9	80861	29188	64388674
Capillary fragility test	14.98	10.96	4	80866	24	64417838
Hand amputation	14.97	10.96	3	80867	3	64417859
Overdose	14.93	10.96	128	80742	159438	64258424
Pulse absent	14.92	10.96	34	80836	8912	64408950
Myiasis	14.84	10.96	4	80866	25	64417837
Emotional distress	14.79	10.96	14	80856	36024	64381838
Body temperature decreased	14.76	10.96	7	80863	25921	64391941
Haemobilia	14.72	10.96	8	80862	389	64417473
Cerebrovascular disorder	14.66	10.96	20	80850	3495	64414367
Haemorrhagic cholecystitis	14.65	10.96	5	80865	75	64417787
Multiple sclerosis relapse	14.64	10.96	18	80852	41117	64376745
Influenza like illness	14.61	10.96	35	80835	61667	64356195
Gait inability	14.59	10.96	19	80851	42349	64375513
Threatened labour	14.59	10.96	9	80861	556	64417306
Platelet aggregation abnormal	14.57	10.96	4	80866	27	64417835
Thrombectomy	14.57	10.96	7	80863	262	64417600
Neuropathy peripheral	14.53	10.96	87	80783	117438	64300424
Injection site plaque	14.52	10.96	5	80865	77	64417785
Blood thrombin increased	14.51	10.96	3	80867	4	64417858
Speech disorder	14.46	10.96	24	80846	48417	64369445
Blood blister	14.29	10.96	17	80853	2591	64415271
Pulmonary fibrosis	14.26	10.96	10	80860	29868	64387994
Right ventricular failure	14.22	10.96	59	80811	21412	64396450
Sleep apnoea syndrome	14.22	10.96	10	80860	29822	64388040
Pseudomonas infection	14.17	10.96	52	80818	17831	64400031
Pulmonary oedema	14.17	10.96	156	80714	78518	64339344
Stomatitis	14.16	10.96	80	80790	109525	64308337
Stress cardiomyopathy	14.15	10.96	34	80836	9223	64408639
Microstomia	14.11	10.96	3	80867	5	64417857
Orthostatic hypotension	14.10	10.96	23	80847	46715	64371147
Nasal congestion	14.00	10.96	34	80836	59624	64358238
Nervousness	13.96	10.96	10	80860	29546	64388316
Cholestatic liver injury	13.95	10.96	20	80850	3659	64414203
Breast haematoma	13.94	10.96	6	80864	173	64417689
Carotid intima-media thickness increased	13.91	10.96	5	80865	88	64417774
Inferior vena caval occlusion	13.87	10.96	4	80866	33	64417829
Graft haemorrhage	13.81	10.96	5	80865	90	64417772
Blood pressure increased	13.76	10.96	144	80726	172408	64245454
Cerebellar embolism	13.76	10.96	3	80867	6	64417856
Migraine	13.73	10.96	37	80833	62640	64355222
Hyperlactacidaemia	13.70	10.96	23	80847	4821	64413041
Phaeochromocytoma crisis	13.69	10.96	7	80863	300	64417562
Thrombolysis	13.69	10.96	6	80864	181	64417681
Drug ineffective for unapproved indication	13.68	10.96	76	80794	31057	64386805
Brain stem infarction	13.66	10.96	14	80856	1809	64416053
Night sweats	13.66	10.96	15	80855	36031	64381831
Transmission of an infectious agent via product	13.66	10.96	6	80864	182	64417680
Splenic haemorrhage	13.58	10.96	9	80861	629	64417233
Hypertensive nephropathy	13.55	10.96	10	80860	831	64417031
Delusion	13.53	10.96	3	80867	18011	64399851
Bursitis	13.52	10.96	5	80865	21480	64396382
Extraocular muscle disorder	13.52	10.96	7	80863	308	64417554
Myocardial haemorrhage	13.47	10.96	4	80866	37	64417825
Joint stiffness	13.45	10.96	11	80859	30393	64387469
Amnesia	13.43	10.96	25	80845	48244	64369618
Paradoxical embolism	13.37	10.96	4	80866	38	64417824
Lipoedema	13.36	10.96	6	80864	192	64417670
Distributive shock	13.33	10.96	14	80856	1861	64416001
Heart rate irregular	13.32	10.96	9	80861	27404	64390458
Factor VIII inhibition	13.31	10.96	7	80863	318	64417544
Ventricular arrhythmia	13.29	10.96	29	80841	7386	64410476
Syncope	13.21	10.96	130	80740	157505	64260357
Portal vein thrombosis	13.20	10.96	23	80847	4968	64412894
Left ventricular dysfunction	13.18	10.96	49	80821	16905	64400957
Vascular parkinsonism	13.18	10.96	5	80865	103	64417759
Vascular access site haematoma	13.16	10.96	3	80867	8	64417854
Carotid artery dissection	13.13	10.96	7	80863	327	64417535
Product contamination microbial	13.12	10.96	10	80860	873	64416989
Throat irritation	13.08	10.96	13	80857	32698	64385164
Nightmare	13.02	10.96	5	80865	20988	64396874
Kidney rupture	12.99	10.96	6	80864	205	64417657
Basophil count decreased	12.97	10.96	6	80864	206	64417656
Necrotising oesophagitis	12.94	10.96	9	80861	681	64417181
Hypertriglyceridaemia	12.88	10.96	37	80833	11168	64406694
Antithrombin III deficiency	12.88	10.96	5	80865	110	64417752
Mouth haemorrhage	12.85	10.96	34	80836	9785	64408077
Injection site bruising	12.85	10.96	16	80854	36357	64381505
Hypoxic-ischaemic encephalopathy	12.85	10.96	28	80842	7124	64410738
Eosinophil cationic protein increased	12.85	10.96	4	80866	44	64417818
Thoracic haemorrhage	12.78	10.96	6	80864	213	64417649
Basal ganglia haemorrhage	12.78	10.96	12	80858	1394	64416468
Purpura	12.71	10.96	49	80821	17197	64400665
Nephrolithiasis	12.71	10.96	22	80848	43661	64374201
Platelet disorder	12.69	10.96	15	80855	2272	64415590
Product preparation error	12.66	10.96	20	80850	3985	64413877
Ruptured cerebral aneurysm	12.61	10.96	8	80862	519	64417343
Klebsiella infection	12.60	10.96	41	80829	13240	64404622
COVID-19	12.58	10.96	131	80739	65009	64352853
Diabetes mellitus	12.57	10.96	42	80828	66432	64351430
Blood pressure systolic increased	12.57	10.96	27	80843	49426	64368436
Aspartate aminotransferase decreased	12.56	10.96	10	80860	930	64416932
Dystonia	12.55	10.96	4	80866	18861	64399001
Kidney transplant rejection	12.52	10.96	33	80837	9478	64408384
Spinal cord haemorrhage	12.50	10.96	8	80862	527	64417335
Respiratory tract oedema	12.49	10.96	9	80861	721	64417141
Postpartum haemorrhage	12.49	10.96	12	80858	1435	64416427
Manufacturing materials issue	12.44	10.96	3	80867	11	64417851
Myelomalacia	12.36	10.96	5	80865	123	64417739
Food interaction	12.35	10.96	12	80858	1454	64416408
Nutritional condition abnormal	12.32	10.96	10	80860	956	64416906
Fear	12.19	10.96	5	80865	20166	64397696
Bone disorder	12.18	10.96	3	80867	16756	64401106
Peripheral artery aneurysm	12.14	10.96	7	80863	382	64417480
Hepatic cytolysis	12.11	10.96	42	80828	14007	64403855
Electrocardiogram T wave alternans	12.10	10.96	4	80866	54	64417808
Femur fracture	12.08	10.96	15	80855	34120	64383742
Arterial injury	12.04	10.96	8	80862	562	64417300
Skin ulcer	12.03	10.96	23	80847	43951	64373911
Bacteraemia	12.03	10.96	66	80804	26845	64391017
Sedation	11.96	10.96	21	80849	41441	64376421
Traumatic haemothorax	11.95	10.96	7	80863	393	64417469
White blood cell count increased	11.93	10.96	131	80739	65883	64351979
Ulcer	11.92	10.96	7	80863	22983	64394879
Vaginal haemorrhage	11.92	10.96	52	80818	19292	64398570
Activated partial thromboplastin time abnormal	11.91	10.96	6	80864	249	64417613
Venous thrombosis limb	11.91	10.96	19	80851	3818	64414044
Foot deformity	11.90	10.96	3	80867	16501	64401361
Pneumonia escherichia	11.89	10.96	9	80861	777	64417085
Ergot poisoning	11.85	10.96	5	80865	137	64417725
Contrast encephalopathy	11.82	10.96	5	80865	138	64417724
Renal tubular necrosis	11.81	10.96	57	80813	22053	64395809
Paranoia	11.74	10.96	3	80867	16349	64401513
Dyspnoea exertional	11.73	10.96	50	80820	73680	64344182
Ureteric haemorrhage	11.69	10.96	3	80867	15	64417847
Septic rash	11.69	10.96	3	80867	15	64417847
Femoral nerve palsy	11.66	10.96	4	80866	61	64417801
Platelet aggregation test	11.66	10.96	4	80866	61	64417801
Extravasation	11.64	10.96	17	80853	3163	64414699
Blister	11.63	10.96	57	80813	80910	64336952
Tracheal haemorrhage	11.59	10.96	8	80862	598	64417264
Coronary artery occlusion	11.52	10.96	41	80829	13850	64404012
Cerebral artery thrombosis	11.52	10.96	10	80860	1049	64416813
Blood sodium decreased	11.47	10.96	12	80858	29470	64388392
Anaphylactoid reaction	11.46	10.96	21	80849	4717	64413145
Abortion early	11.38	10.96	3	80867	17	64417845
Cardiac failure	11.37	10.96	231	80639	132142	64285720
Haematidrosis	11.37	10.96	4	80866	66	64417796
Lumbar puncture	11.34	10.96	5	80865	153	64417709
Spinal cord disorder	11.31	10.96	12	80858	1614	64416248
Premature baby	11.27	10.96	17	80853	3255	64414607
Immune thrombocytopenia	11.26	10.96	43	80827	15023	64402839
Herpes simplex hepatitis	11.26	10.96	7	80863	438	64417424
Fungal disease carrier	11.24	10.96	6	80864	281	64417581
Microangiopathic haemolytic anaemia	11.20	10.96	11	80859	1351	64416511
Staphylococcus test positive	11.19	10.96	23	80847	5622	64412240
Paralysis	11.18	10.96	36	80834	11559	64406303
Mediastinal haemorrhage	11.15	10.96	4	80866	70	64417792
Reperfusion arrhythmia	11.15	10.96	6	80864	286	64417576
Hypoaesthesia	11.13	10.96	116	80754	138992	64278870
Toothache	11.09	10.96	4	80866	17455	64400407
Anger	11.09	10.96	3	80867	15738	64402124
Organic brain syndrome	11.08	10.96	7	80863	451	64417411
Renal artery stenosis	11.05	10.96	16	80854	2953	64414909
Hyperglycaemia	11.02	10.96	121	80749	60847	64357015
Pituitary haemorrhage	10.99	10.96	6	80864	294	64417568
Movement disorder	10.99	10.96	7	80863	21993	64395869
Subdural haemorrhage	10.98	10.96	22	80848	5281	64412581

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B01AB01	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Heparin group
ATC	B01AB51	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Heparin group
ATC	C05BA03	CARDIOVASCULAR SYSTEM VASOPROTECTIVES ANTIVARICOSE THERAPY Heparins or heparinoids for topical use
ATC	C05BA53	CARDIOVASCULAR SYSTEM VASOPROTECTIVES ANTIVARICOSE THERAPY Heparins or heparinoids for topical use
ATC	S01XA14	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
FDA CS	M0010187	Heparin
FDA EPC	N0000175474	Unfractionated Heparin
MeSH PA	D000925	Anticoagulants
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D005343	Fibrinolytic Agents
MeSH PA	D006401	Hematologic Agents
FDA EPC	N0000175980	Anti-coagulant
CHEBI has role	CHEBI:50249	anticoagulants

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Disseminated intravascular coagulation	indication	67406007	DOID:11247
Deep venous thrombosis	indication	128053003
Pulmonary thromboembolism	indication	233935004
Peripheral arterial embolism	indication	286959000
Non-Q wave myocardial infarction	indication	314207007
Prevention of deep vein thrombosis	indication	439993001
Deep Vein Thrombosis with Pulmonary Embolism	indication
Prevention of Recurrent Venous Thrombosis Associated with Malignancy	indication
Pulmonary Thromboembolism Prevention	indication
Peripheral Arterial Thromboembolism Prevention	indication
Maintain Patency of Indwelling Vascular Catheter	indication
Prevention of Ischemic Complications of Non-Q Wave MI	indication
Prevention of Cardiac Ischemia in Unstable Angina	indication
Myocardial infarction	off-label use	22298006	DOID:5844
Coronavirus infection	off-label use	186747009
Acute coronary syndrome	off-label use	394659003
Percutaneous coronary intervention	off-label use	415070008
Intracranial hemorrhage	contraindication	1386000
Diabetic retinopathy	contraindication	4855003	DOID:8947
Hypertensive retinopathy	contraindication	6962006	DOID:11561
Retinal disorder	contraindication	29555009	DOID:5679
Antithrombin III deficiency	contraindication	36351005	DOID:3755
Gastrointestinal ulcer	contraindication	40845000
Threatened abortion	contraindication	54048003	DOID:9667
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Ulcerative colitis	contraindication	64766004	DOID:8577
Blood coagulation disorder	contraindication	64779008	DOID:1247
Osteoporosis	contraindication	64859006	DOID:11476
Operation on brain	contraindication	70586009
Heparin-induced thrombocytopenia	contraindication	73397007
Gastrointestinal hemorrhage	contraindication	74474003
Ulceration of intestine	contraindication	85942002
Acute gastric ulcer with hemorrhage	contraindication	89748001
Hemophilia	contraindication	90935002
Disorder of biliary tract	contraindication	105997008	DOID:9741
Procedure on central nervous system	contraindication	118679007
Bleeding	contraindication	131148009
Disease of blood AND/OR blood-forming organ	contraindication	191124002	DOID:74
Hemorrhagic cerebral infarction	contraindication	230706003
Local anesthetic intrathecal block	contraindication	231249005
Infective endocarditis	contraindication	233850007
Procedure on spine	contraindication	238181003
Qualitative platelet disorder	contraindication	267532001
Diverticulitis of gastrointestinal tract	contraindication	271366000
Cerebral hemorrhage	contraindication	274100004
Lumbar puncture	contraindication	277762005
Bacterial endocarditis	contraindication	301183007
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Dissection of aorta	contraindication	308546005
Arteriosclerosis obliterans	contraindication	361133006	DOID:5160
Surgical procedure on eye proper	contraindication	373353005
Hypertensive urgency	contraindication	443482000
Placement of Epidural Catheter	contraindication
Thrombosis in Heparin Induced Thrombocytopenia	contraindication
Platelet Aggregation Inhibition	contraindication
Spinal Epidural Hematoma	contraindication
Significant Bleeding	contraindication
Indwelling Vascular Catheter	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Antithrombin-III	Secreted	P01008	ANT3_HUMAN	ACTIVATOR	Kd	7.85		IUPHAR	CHEMBL
Spike glycoprotein	Glycoprotein		SPIKE_SARS2		Kd	10.14		IUPHAR
Spike glycoprotein, S glycoprotein	Unclassified		SPIKE_SARS		Kd	6.30		IUPHAR

External reference:

ID	Source
D02112	KEGG_DRUG
4017546	VANDF
4017547	VANDF
4017549	VANDF
4018538	VANDF
C0019134	UMLSCUI
CHEBI:28304	CHEBI
CHEMBL1909300	ChEMBL_ID
CHEMBL4650299	ChEMBL_ID
CHEMBL1201657	ChEMBL_ID
D006493	MESH_DESCRIPTOR_UI
DB01109	DRUGBANK_ID
4214	IUPHAR_LIGAND_ID
37270-89-6	SECONDARY_CAS_RN
T2410KM04A	UNII
92044406	PUBCHEM_CID
20044	RXNORM
3649	MMSL
4821	MMSL
d00252	MMSL
002079	NDDF
002081	NDDF
015153	NDDF
29725000	SNOMEDCT_US
372877000	SNOMEDCT_US
412201008	SNOMEDCT_US
412401006	SNOMEDCT_US
50045009	SNOMEDCT_US
784398008	SNOMEDCT_US
84812008	SNOMEDCT_US
CHEMBL1201513	ChEMBL_ID
M7J	PDB_CHEM_ID
392	INN_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0043	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0058	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0059	INJECTION	5000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0062	INJECTION	10000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0137	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0264-5705	INJECTION	5000 [USPU]	INTRAVENOUS	ANDA	20 sections
Heparin Sodium in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	2	0264-9567	INJECTION	4000 [USPU]	INTRAVENOUS	NDA	19 sections
Heparin Sodium in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	2	0264-9577	INJECTION	5000 [USPU]	INTRAVENOUS	NDA	19 sections
Heparin Sodium in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	2	0264-9587	INJECTION	10000 [USPU]	INTRAVENOUS	NDA	19 sections
Heparin Sodium in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	0264-9872	INJECTION	200 [USPU]	INTRAVENOUS	NDA	23 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0424	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0428	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0431	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0433	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9872	INJECTION, SOLUTION	5000 [USPU]	INTRAVENOUS	ANDA	14 sections
HEPARIN SODIUM	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9873	INJECTION	10000 [USPU]	INTRAVENOUS	ANDA	14 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9979	INJECTION, SOLUTION	1000 [USPU]	INTRAVENOUS	NDA	16 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-1316	INJECTION, SOLUTION	10000 [USPU]	SUBCUTANEOUS	ANDA	25 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-1402	INJECTION, SOLUTION	5000 [USPU]	SUBCUTANEOUS	ANDA	25 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-2720	INJECTION, SOLUTION	1000 [USPU]	SUBCUTANEOUS	ANDA	25 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-2721	INJECTION, SOLUTION	10000 [USPU]	INTRAVENOUS	ANDA	25 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-2723	INJECTION, SOLUTION	5000 [USPU]	SUBCUTANEOUS	ANDA	25 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-7620	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	27 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-7650	INJECTION, SOLUTION	10000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-7651	INJECTION, SOLUTION	5000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium and Dextrose	HUMAN PRESCRIPTION DRUG LABEL	1	0409-7793	INJECTION, SOLUTION	10000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium and Dextrose	HUMAN PRESCRIPTION DRUG LABEL	1	0409-7794	INJECTION, SOLUTION	5000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0641-0391	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0641-0400	INJECTION	5000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0641-0410	INJECTION	10000 [USPU]	INTRAVENOUS	NDA	24 sections