heparin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
heparin derivatives including low molecular mass heparins 1358 9005-49-6

Description:

MoleculeDescription

Synonyms:

  • heparin
  • heparin sodium
  • heparin calcium
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
10 TU P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 9, 1939 FDA ORGANON USA INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heparin-induced thrombocytopenia 2864.45 10.89 735 59545 3574 46622208
Renal injury 315.28 10.89 180 60100 9361 46616421
Fear 295.92 10.89 210 60070 15962 46609820
Activated partial thromboplastin time prolonged 274.38 10.89 147 60133 6742 46619040
Haemorrhage 267.87 10.89 342 59938 54527 46571255
Rheumatoid arthritis 256.66 10.89 13 60267 240202 46385580
Multiple organ dysfunction syndrome 251.93 10.89 322 59958 51388 46574394
Anhedonia 246.02 10.89 158 60122 10177 46615605
Renal failure 245.07 10.89 487 59793 113107 46512675
Thrombocytopenia 237.10 10.89 512 59768 126069 46499713
Retroperitoneal haemorrhage 234.79 10.89 99 60181 2631 46623151
Shock haemorrhagic 215.61 10.89 136 60144 8488 46617294
Thrombosis in device 210.35 10.89 94 60186 2885 46622897
Cerebral haemorrhage 204.16 10.89 216 60064 28155 46597627
Maternal exposure during pregnancy 203.75 10.89 425 59855 102124 46523658
Injury 203.23 10.89 267 60013 43760 46582022
Haemorrhage intracranial 202.76 10.89 152 60128 12572 46613210
Premature delivery 182.32 10.89 181 60099 21888 46603894
Pulmonary embolism 179.47 10.89 418 59862 108167 46517615
Arthralgia 174.45 10.89 130 60150 364473 46261309
Emotional distress 173.33 10.89 206 60074 30501 46595281
Completed suicide 173.27 10.89 3 60277 145917 46479865
Haematoma 172.02 10.89 209 60071 31663 46594119
Retroperitoneal haematoma 163.39 10.89 76 60204 2564 46623218
Unevaluable event 161.16 10.89 245 60035 45930 46579852
Labelled drug-drug interaction medication error 159.61 10.89 115 60165 8946 46616836
Vascular stent thrombosis 152.35 10.89 53 60227 818 46624964
Hereditary angioedema 145.47 10.89 90 60190 5426 46620356
Cardiogenic shock 132.78 10.89 133 60147 16251 46609531
Drug ineffective 128.73 10.89 448 59832 677390 45948392
Vascular pseudoaneurysm 128.61 10.89 53 60227 1327 46624455
Thrombosis 127.55 10.89 246 60034 55823 46569959
Extradural haematoma 123.69 10.89 52 60228 1371 46624411
Joint swelling 118.09 10.89 34 60246 166039 46459743
Abdominal wall haematoma 116.18 10.89 62 60218 2819 46622963
Drug intolerance 112.40 10.89 26 60254 147023 46478759
Fatigue 112.31 10.89 407 59873 608290 46017492
Exposure during pregnancy 107.83 10.89 346 59934 107866 46517916
Deep vein thrombosis 106.30 10.89 283 59997 79490 46546292
Haemoglobin decreased 105.47 10.89 386 59894 128563 46497219
Acute kidney injury 105.41 10.89 590 59690 235265 46390517
Product dose omission issue 105.12 10.89 43 60237 168477 46457305
Cerebral infarction 103.61 10.89 139 60141 23227 46602555
Cardiac arrest 102.10 10.89 302 59978 90097 46535685
Hypotension 101.40 10.89 578 59702 232011 46393771
Renal impairment 100.27 10.89 265 60015 74107 46551675
Coronary artery thrombosis 92.74 10.89 40 60240 1125 46624657
Compartment syndrome 91.99 10.89 47 60233 1952 46623830
Cardiac tamponade 86.48 10.89 60 60220 4394 46621388
Platelet count decreased 85.65 10.89 304 59976 99720 46526062
Malaise 85.64 10.89 188 60092 331044 46294738
Toxic epidermal necrolysis 84.56 10.89 123 60157 22155 46603627
Disseminated intravascular coagulation 84.17 10.89 113 60167 18892 46606890
Haemoperitoneum 82.44 10.89 47 60233 2435 46623347
Psoriasis 81.52 10.89 5 60275 78599 46547183
Arthropathy 80.53 10.89 8 60272 84692 46541090
Alopecia 79.96 10.89 56 60224 162358 46463424
Haemothorax 77.26 10.89 42 60238 1982 46623800
Peripheral ischaemia 76.06 10.89 56 60224 4503 46621279
Spinal epidural haematoma 75.94 10.89 31 60249 757 46625025
Premature baby 74.64 10.89 104 60176 18008 46607774
Nasopharyngitis 73.33 10.89 55 60225 153943 46471839
Embolism 71.21 10.89 65 60215 7073 46618709
Toxicity to various agents 69.14 10.89 104 60176 211662 46414120
Vena cava thrombosis 69.00 10.89 40 60240 2139 46623643
Respiratory failure 68.55 10.89 273 60007 94543 46531239
Haematoma muscle 68.47 10.89 27 60253 601 46625181
Pharyngeal haemorrhage 68.37 10.89 26 60254 523 46625259
Coagulation time shortened 67.84 10.89 19 60261 135 46625647
Muscle haemorrhage 67.67 10.89 46 60234 3258 46622524
Adrenal haemorrhage 67.02 10.89 23 60257 340 46625442
Diarrhoea 66.99 10.89 436 59844 559166 46066616
Gastrointestinal haemorrhage 66.93 10.89 236 60044 77137 46548645
Subarachnoid haemorrhage 66.53 10.89 77 60203 11076 46614706
Procedural haemorrhage 65.64 10.89 40 60240 2346 46623436
Subdural haematoma 64.91 10.89 82 60198 12915 46612867
Intentional overdose 64.81 10.89 5 60275 64939 46560843
Skin necrosis 64.53 10.89 67 60213 8537 46617245
Heparin-induced thrombocytopenia test positive 64.40 10.89 12 60268 4 46625778
Cardiac valve replacement complication 63.60 10.89 19 60261 174 46625608
Drug abuse 62.94 10.89 5 60275 63403 46562379
Coagulopathy 61.47 10.89 96 60184 18403 46607379
Abdominal discomfort 61.09 10.89 63 60217 151102 46474680
Injection site pain 61.08 10.89 31 60249 107121 46518661
Coagulation time prolonged 60.77 10.89 31 60249 1283 46624499
Puncture site haemorrhage 60.49 10.89 20 60260 262 46625520
Post procedural haemorrhage 59.64 10.89 60 60220 7366 46618416
Stress 58.90 10.89 173 60107 51378 46574404
Weight decreased 58.35 10.89 115 60165 210734 46415048
Caesarean section 57.75 10.89 88 60192 16515 46609267
Weight increased 57.40 10.89 77 60203 164396 46461386
Suicidal ideation 57.23 10.89 4 60276 56378 46569404
Dizziness 57.12 10.89 236 60044 340178 46285604
Blood pressure decreased 57.08 10.89 183 60097 56976 46568806
Acute myocardial infarction 56.07 10.89 126 60154 31798 46593984
Ventricular tachycardia 54.92 10.89 87 60193 16880 46608902
Gait disturbance 53.80 10.89 65 60215 145198 46480584
Shock 53.55 10.89 99 60181 21746 46604036
Sepsis 53.34 10.89 329 59951 135685 46490097
Foetal death 53.22 10.89 61 60219 8682 46617100
Treatment failure 52.95 10.89 27 60253 93060 46532722
Insomnia 52.84 10.89 82 60198 164842 46460940
Arthritis 52.79 10.89 17 60263 77299 46548483
Subchorionic haematoma 52.56 10.89 15 60265 115 46625667
Infective aneurysm 51.88 10.89 20 60260 418 46625364
Intra-abdominal haematoma 51.81 10.89 30 60250 1601 46624181
Intracardiac thrombus 51.76 10.89 34 60246 2274 46623508
Pericardial haemorrhage 50.52 10.89 29 60251 1522 46624260
Therapeutic product effect incomplete 50.24 10.89 19 60261 78134 46547648
Pain in extremity 50.10 10.89 169 60111 258511 46367271
Haematocrit decreased 49.34 10.89 127 60153 34930 46590852
Arterial thrombosis 48.85 10.89 27 60253 1317 46624465
Fall 48.10 10.89 240 60040 328857 46296925
Stevens-Johnson syndrome 47.87 10.89 98 60182 23199 46602583
Memory impairment 47.75 10.89 20 60260 77317 46548465
Aortic thrombosis 47.55 10.89 24 60256 971 46624811
Gangrene 47.32 10.89 43 60237 4652 46621130
Asthma 47.13 10.89 30 60250 91512 46534270
Intra-abdominal haemorrhage 46.67 10.89 32 60248 2298 46623484
Pemphigus 46.57 10.89 3 60277 45271 46580511
Post procedural complication 45.96 10.89 77 60203 15652 46610130
Splenic rupture 45.94 10.89 25 60255 1182 46624600
Brain herniation 45.69 10.89 35 60245 2988 46622794
Pulmonary alveolar haemorrhage 45.68 10.89 40 60240 4122 46621660
Low birth weight baby 45.66 10.89 45 60235 5389 46620393
Electrocardiogram ST segment elevation 45.63 10.89 38 60242 3657 46622125
Suicide attempt 45.62 10.89 8 60272 55028 46570754
Rash 44.98 10.89 273 60007 356239 46269543
Peripheral swelling 44.76 10.89 85 60195 157986 46467796
Choroidal infarction 44.59 10.89 12 60268 72 46625710
Catheter site haemorrhage 44.57 10.89 33 60247 2676 46623106
Feeling abnormal 44.18 10.89 58 60222 125002 46500780
Musculoskeletal stiffness 44.10 10.89 37 60243 97956 46527826
Aplastic anaemia 43.70 10.89 50 60230 7103 46618679
Thrombotic microangiopathy 42.42 10.89 53 60227 8253 46617529
Haemodynamic instability 42.21 10.89 51 60229 7674 46618108
Product use in unapproved indication 41.64 10.89 228 60052 90045 46535737
Paraplegia 41.28 10.89 30 60250 2364 46623418
Venous thrombosis 41.06 10.89 40 60240 4722 46621060
Myalgia 40.56 10.89 60 60220 123028 46502754
Acute motor-sensory axonal neuropathy 40.49 10.89 16 60264 358 46625424
Foetal exposure during pregnancy 39.82 10.89 108 60172 30639 46595143
Eye excision 39.19 10.89 10 60270 47 46625735
Peripheral artery thrombosis 38.99 10.89 26 60254 1783 46623999
Injection site erythema 38.85 10.89 24 60256 74403 46551379
Intentional product misuse 38.74 10.89 7 60273 47121 46578661
Pulmonary infarction 38.35 10.89 30 60250 2641 46623141
Petechiae 38.32 10.89 63 60217 12607 46613175
Procedural complication 38.07 10.89 39 60241 4891 46620891
Hypoxia 38.03 10.89 150 60130 51688 46574094
Intraventricular haemorrhage 37.77 10.89 26 60254 1879 46623903
Pulmonary haemorrhage 37.28 10.89 44 60236 6461 46619321
Muscle spasms 36.81 10.89 64 60216 123049 46502733
Retinal pigment epitheliopathy 36.43 10.89 13 60267 217 46625565
Ischaemic stroke 36.33 10.89 72 60208 16650 46609132
Peritonitis bacterial 36.11 10.89 50 60230 8603 46617179
Ventricular fibrillation 35.91 10.89 58 60222 11438 46614344
Oliguria 35.64 10.89 50 60230 8709 46617073
Systemic lupus erythematosus 34.04 10.89 21 60259 65159 46560623
Hemiparesis 33.89 10.89 78 60202 19991 46605791
International normalised ratio increased 33.86 10.89 135 60145 46748 46579034
Spinal cord compression 33.76 10.89 32 60248 3652 46622130
Leg amputation 33.65 10.89 25 60255 2038 46623744
Rectosigmoid cancer 33.14 10.89 11 60269 146 46625636
Fluid overload 32.75 10.89 93 60187 27092 46598690
Splenic infarction 32.46 10.89 22 60258 1550 46624232
Injection site pruritus 32.46 10.89 6 60274 39737 46586045
Septic shock 32.11 10.89 154 60126 57739 46568043
Loss of personal independence in daily activities 31.89 10.89 17 60263 57166 46568616
Atrial thrombosis 31.72 10.89 21 60259 1423 46624359
Eosinophilia 31.69 10.89 74 60206 19143 46606639
Platelet aggregation inhibition 31.51 10.89 10 60270 114 46625668
Gastrooesophageal reflux disease 31.14 10.89 30 60250 74314 46551468
Coronary artery dissection 31.10 10.89 16 60264 674 46625108
Extraocular muscle disorder 31.04 10.89 10 60270 120 46625662
Injection site swelling 31.04 10.89 7 60273 40320 46585462
Protein C decreased 30.95 10.89 8 60272 40 46625742
Pulseless electrical activity 30.79 10.89 42 60238 7125 46618657
Intracranial haematoma 30.67 10.89 13 60267 350 46625432
Fear of death 30.62 10.89 18 60262 988 46624794
Oesophageal intramural haematoma 30.17 10.89 9 60271 82 46625700
Procedural hypotension 30.15 10.89 19 60261 1183 46624599
Injection site reaction 30.14 10.89 12 60268 47837 46577945
Catheter site haematoma 29.83 10.89 10 60270 137 46625645
Embolic cerebral infarction 29.72 10.89 14 60266 486 46625296
HELLP syndrome 29.33 10.89 17 60263 909 46624873
Heparin-induced thrombocytopenia test 29.29 10.89 6 60274 7 46625775
Protein S decreased 29.18 10.89 8 60272 52 46625730
Tachypnoea 29.04 10.89 60 60220 14291 46611491
Ischaemia 28.86 10.89 32 60248 4392 46621390
Hemiplegia 28.82 10.89 40 60240 6898 46618884
Blood cholesterol increased 28.76 10.89 8 60272 40005 46585777
Cerebral venous thrombosis 28.63 10.89 23 60257 2104 46623678
Osteoarthritis 28.42 10.89 23 60257 62002 46563780
Hand amputation 28.27 10.89 5 60275 0 46625782
Haemorrhagic transformation stroke 28.11 10.89 18 60262 1152 46624630
Prothrombin time prolonged 28.06 10.89 47 60233 9549 46616233
Influenza 27.98 10.89 45 60235 89225 46536557
Wrong technique in product usage process 27.78 10.89 18 60262 54404 46571378
Toxoplasmosis 27.58 10.89 19 60261 1375 46624407
Hypercoagulation 27.51 10.89 22 60258 2000 46623782
Acute generalised exanthematous pustulosis 27.42 10.89 46 60234 9359 46616423
Device related infection 27.34 10.89 74 60206 20967 46604815
Headache 27.34 10.89 444 59836 477908 46147874
Renal infarct 27.33 10.89 18 60262 1209 46624573
Spinal subdural haematoma 27.14 10.89 9 60271 119 46625663
Cerebral haematoma 26.85 10.89 27 60253 3312 46622470
Product measured potency issue 26.80 10.89 9 60271 124 46625658
Haemodialysis 26.76 10.89 45 60235 9172 46616610
Renal vein thrombosis 26.34 10.89 11 60269 285 46625497
Anxiety 26.19 10.89 354 59926 181603 46444179
Cerebellar haemorrhage 26.03 10.89 18 60262 1311 46624471
Jugular vein thrombosis 26.02 10.89 24 60256 2646 46623136
Pulse absent 25.91 10.89 32 60248 4924 46620858
Mobility decreased 25.90 10.89 24 60256 60570 46565212
Post procedural haematoma 25.76 10.89 18 60262 1333 46624449
Product contamination 25.62 10.89 13 60267 532 46625250
Asthenia 25.37 10.89 268 60012 310807 46314975
Haemoptysis 25.36 10.89 83 60197 26106 46599676
Anti factor Xa activity decreased 25.33 10.89 5 60275 4 46625778
Haemolysis 25.27 10.89 35 60245 6024 46619758
Device expulsion 25.15 10.89 3 60277 27539 46598243
Pulmonary artery thrombosis 24.97 10.89 14 60266 702 46625080
Lipoedema 24.75 10.89 9 60271 159 46625623
Acute respiratory distress syndrome 24.48 10.89 73 60207 21849 46603933
Drug chemical incompatibility 24.38 10.89 7 60273 55 46625727
Vasodilatation 24.34 10.89 22 60258 2363 46623419
Peritonitis 24.11 10.89 70 60210 20644 46605138
Peritoneal dialysis complication 23.93 10.89 23 60257 2671 46623111
Graft thrombosis 23.85 10.89 9 60271 177 46625605
Pituitary apoplexy 23.77 10.89 8 60272 111 46625671
Encephalopathy 23.67 10.89 96 60184 33493 46592289
Transcription medication error 23.67 10.89 9 60271 181 46625601
Coronary artery perforation 23.55 10.89 6 60274 28 46625754
Cerebrovascular accident 23.43 10.89 216 60064 100823 46524959
Subcapsular renal haematoma 23.43 10.89 10 60270 274 46625508
Tremor 23.41 10.89 74 60206 115565 46510217
Breast cancer 23.30 10.89 15 60265 45503 46580279
Tonsillar haemorrhage 23.18 10.89 9 60271 192 46625590
Somnolence 22.89 10.89 114 60166 156407 46469375
Cerebellar embolism 22.61 10.89 4 60276 0 46625782
Decreased appetite 22.56 10.89 152 60128 193684 46432098
Haematuria 22.41 10.89 81 60199 26777 46599005
Blood fibrinogen decreased 22.39 10.89 13 60267 697 46625085
Choroidal effusion 22.31 10.89 11 60269 423 46625359
Lower respiratory tract infection 22.18 10.89 23 60257 55066 46570716
Arterial intramural haematoma 22.16 10.89 5 60275 12 46625770
Wound 22.06 10.89 14 60266 42788 46582994
Dry mouth 22.04 10.89 23 60257 54903 46570879
Coagulation time abnormal 22.04 10.89 7 60273 80 46625702
Stillbirth 22 10.89 34 60246 6457 46619325
Arterial haemorrhage 21.91 10.89 18 60262 1700 46624082
Mediastinal haemorrhage 21.88 10.89 5 60275 13 46625769
Cataract 21.87 10.89 16 60264 45399 46580383
Foetal growth restriction 21.70 10.89 34 60246 6533 46619249
Abdominal compartment syndrome 21.64 10.89 12 60268 589 46625193
Hydrocephalus 21.59 10.89 29 60251 4848 46620934
Hepatic infarction 21.58 10.89 12 60268 592 46625190
Incorrect drug administration rate 21.56 10.89 19 60261 1974 46623808
Cerebral amyloid angiopathy 21.41 10.89 8 60272 153 46625629
Spinal cord disorder 21.37 10.89 15 60265 1119 46624663
Fibrin D dimer increased 21.33 10.89 26 60254 3947 46621835
Stress cardiomyopathy 21.28 10.89 37 60243 7747 46618035
Inflammation 21.23 10.89 19 60261 48762 46577020
Ischaemic hepatitis 21.08 10.89 19 60261 2034 46623748
Contraindicated product administered 20.89 10.89 45 60235 79902 46545880
Haemorrhage subcutaneous 20.67 10.89 22 60258 2884 46622898
Cerebral artery thrombosis 20.66 10.89 10 60270 369 46625413
Arm amputation 20.66 10.89 5 60275 18 46625764
Premature rupture of membranes 20.66 10.89 27 60253 4396 46621386
Cerebral artery embolism 20.52 10.89 13 60267 817 46624965
Cerebral vasoconstriction 20.25 10.89 14 60266 1019 46624763
Blood pressure fluctuation 20.24 10.89 7 60273 30441 46595341
Incision site haemorrhage 20.24 10.89 11 60269 519 46625263
Haemorrhagic stroke 20.06 10.89 30 60250 5536 46620246
Hypersensitivity 20.02 10.89 113 60167 150208 46475574
Cerebral reperfusion injury 19.85 10.89 4 60276 4 46625778
Haemorrhagic infarction 19.81 10.89 9 60271 287 46625495
Anti-platelet antibody positive 19.79 10.89 6 60274 58 46625724
Paratonia 19.68 10.89 5 60275 23 46625759
Product administration error 19.62 10.89 63 60217 19618 46606164
Back pain 19.61 10.89 175 60105 209864 46415918
Hepatic haematoma 19.47 10.89 10 60270 420 46625362
Atrial fibrillation 19.45 10.89 212 60068 103378 46522404
Psychotic disorder 19.39 10.89 3 60277 22618 46603164
Peritoneal haematoma 19.35 10.89 6 60274 63 46625719
Spinal cord oedema 19.28 10.89 7 60273 123 46625659
Vascular pseudoaneurysm ruptured 19.18 10.89 6 60274 65 46625717
Postpartum haemorrhage 19.18 10.89 17 60263 1780 46624002
Rash maculo-papular 19.12 10.89 79 60201 27795 46597987
Suspected transmission of an infectious agent via product 19.02 10.89 8 60272 211 46625571
Fungal sepsis 18.93 10.89 14 60266 1133 46624649
Balance disorder 18.86 10.89 34 60246 64487 46561295
Visual impairment 18.73 10.89 36 60244 66653 46559129
Vascular access site haemorrhage 18.58 10.89 4 60276 7 46625775
Device occlusion 18.57 10.89 30 60250 5915 46619867
Mucosal erosion 18.57 10.89 15 60265 1383 46624399
Blood creatinine increased 18.56 10.89 165 60115 76238 46549544
Respiratory distress 18.50 10.89 86 60194 31830 46593952
Dry eye 18.46 10.89 8 60272 30314 46595468
Depressed mood 18.44 10.89 10 60270 33309 46592473
Pulmonary oedema 18.38 10.89 121 60159 50984 46574798
Vasospasm 18.37 10.89 11 60269 625 46625157
Dyspepsia 18.34 10.89 38 60242 68434 46557348
Activated partial thromboplastin time shortened 18.16 10.89 9 60271 350 46625432
Unresponsive to stimuli 18.14 10.89 86 60194 32088 46593694
Arterial stenosis 18.13 10.89 11 60269 640 46625142
Cardiac failure 18.07 10.89 170 60110 79778 46546004
Infection 18.02 10.89 100 60180 133492 46492290
Tachycardia 17.84 10.89 202 60078 99420 46526362
Kidney rupture 17.79 10.89 5 60275 36 46625746
Calciphylaxis 17.69 10.89 19 60261 2516 46623266
Iris neovascularisation 17.67 10.89 5 60275 37 46625745
Haemodialysis complication 17.53 10.89 8 60272 258 46625524
Blood albumin decreased 17.51 10.89 48 60232 13697 46612085
Anaemia 17.47 10.89 443 59837 255336 46370446
Osteoporosis 17.45 10.89 16 60264 40592 46585190
Ventricle rupture 17.34 10.89 4 60276 11 46625771
Myelomalacia 17.33 10.89 5 60275 40 46625742
Similar reaction on previous exposure to drug 17.23 10.89 5 60275 41 46625741
Subdural haemorrhage 17.19 10.89 20 60260 2892 46622890
Spinal cord haemorrhage 17.18 10.89 7 60273 170 46625612
Ureteric haemorrhage 16.96 10.89 3 60277 0 46625782
Rhinorrhoea 16.93 10.89 22 60258 47643 46578139
Injection site plaque 16.81 10.89 5 60275 45 46625737
Phaeochromocytoma crisis 16.78 10.89 7 60273 181 46625601
Ecchymosis 16.65 10.89 40 60240 10536 46615246
Cardiac death 16.62 10.89 10 60270 573 46625209
Ejection fraction decreased 16.61 10.89 56 60224 17881 46607901
Neurological symptom 16.55 10.89 25 60255 4654 46621128
Foetal exposure timing unspecified 16.36 10.89 7 60273 193 46625589
Adverse drug reaction 16.25 10.89 20 60260 44342 46581440
Sleep disorder 16.21 10.89 22 60258 46773 46579009
Immune thrombocytopenia 16.14 10.89 34 60246 8207 46617575
Organ failure 16.10 10.89 18 60262 2492 46623290
Fat embolism 16.06 10.89 7 60273 202 46625580
Platelet aggregation test 16.00 10.89 4 60276 17 46625765
Antiphospholipid syndrome 15.93 10.89 15 60265 1697 46624085
Swelling 15.83 10.89 95 60185 124416 46501366
Blood culture positive 15.81 10.89 24 60256 4488 46621294
Threatened labour 15.80 10.89 11 60269 810 46624972
Red blood cell sedimentation rate increased 15.68 10.89 5 60275 22884 46602898
Retinoblastoma 15.49 10.89 6 60274 127 46625655
Hepatic enzyme increased 15.41 10.89 54 60226 81733 46544049
Dysphagia 15.28 10.89 50 60230 77262 46548520
Pleural effusion 15.22 10.89 169 60111 82783 46542999
Cough 15.07 10.89 208 60072 230041 46395741
Premature labour 14.94 10.89 40 60240 11259 46614523
Mouth ulceration 14.93 10.89 8 60272 26824 46598958
Ill-defined disorder 14.92 10.89 8 60272 26819 46598963
Bradycardia foetal 14.90 10.89 8 60272 368 46625414
Aneurysm recanalisation 14.89 10.89 3 60277 3 46625779
Medical device site thrombosis 14.89 10.89 3 60277 3 46625779
Pelvic venous thrombosis 14.88 10.89 14 60266 1583 46624199
Capillary fragility test 14.86 10.89 4 60276 24 46625758
Thrombolysis 14.82 10.89 5 60275 70 46625712
Necrosis 14.77 10.89 24 60256 4756 46621026
Vision blurred 14.77 10.89 53 60227 79655 46546127
Nervous system disorder 14.63 10.89 50 60230 16079 46609703
Dialysis 14.59 10.89 37 60243 10079 46615703
Platelet transfusion 14.57 10.89 10 60270 719 46625063
Carotid artery thrombosis 14.56 10.89 10 60270 720 46625062
Venous occlusion 14.52 10.89 10 60270 723 46625059
Acute respiratory failure 14.38 10.89 75 60205 29063 46596719
Multiple sclerosis 14.37 10.89 7 60273 24784 46600998
Blood creatine increased 14.12 10.89 23 60257 4567 46621215
Organic brain syndrome 14.10 10.89 6 60274 163 46625619
Live birth 14.09 10.89 37 60243 10293 46615489
Intestinal ischaemia 14.07 10.89 29 60251 6896 46618886
Cerebrovascular disorder 14.04 10.89 18 60262 2876 46622906
Cyanosis 14.04 10.89 49 60231 15922 46609860
Artery dissection 13.98 10.89 5 60275 84 46625698
Uterine haematoma 13.98 10.89 4 60276 31 46625751
Renal artery thrombosis 13.93 10.89 5 60275 85 46625697
Infarction 13.91 10.89 16 60264 2285 46623497
Seizure like phenomena 13.91 10.89 11 60269 984 46624798
Fibromyalgia 13.82 10.89 16 60264 36447 46589335
Crying 13.81 10.89 5 60275 21136 46604646
Hepatic failure 13.81 10.89 82 60198 33334 46592448
Haemorrhagic cerebral infarction 13.77 10.89 9 60271 597 46625185
Antithrombin III decreased 13.76 10.89 7 60273 288 46625494
Accidental exposure to product 13.75 10.89 5 60275 21076 46604706
Renal haematoma 13.71 10.89 6 60274 175 46625607
Renal haemorrhage 13.67 10.89 10 60270 796 46624986
Bleeding time prolonged 13.63 10.89 9 60271 607 46625175
Herpes simplex hepatitis 13.60 10.89 7 60273 295 46625487
Febrile neutropenia 13.55 10.89 184 60096 94443 46531339
Cardiopulmonary failure 13.54 10.89 20 60260 3649 46622133
Nephrogenic systemic fibrosis 13.46 10.89 23 60257 4749 46621033
Cholestatic liver injury 13.43 10.89 15 60265 2075 46623707
Multiple sclerosis relapse 13.42 10.89 21 60259 42104 46583678
Therapy cessation 13.33 10.89 9 60271 26620 46599162
Recurrence of neuromuscular blockade 13.27 10.89 5 60275 98 46625684
Cardiac ventricular thrombosis 13.22 10.89 8 60272 463 46625319
Femur fracture 13.21 10.89 17 60263 36980 46588802
Vessel puncture site haemorrhage 13.17 10.89 5 60275 100 46625682
Subclavian vein thrombosis 13.17 10.89 14 60266 1832 46623950
Osteonecrosis of jaw 13.14 10.89 15 60265 34387 46591395
Injection site bruising 13.12 10.89 16 60264 35620 46590162
Foetal warfarin syndrome 13.07 10.89 3 60277 8 46625774
Circulatory collapse 13.07 10.89 59 60221 21565 46604217
International normalised ratio decreased 13.03 10.89 22 60258 4498 46621284
Hemianopia homonymous 12.98 10.89 9 60271 658 46625124
Aneurysm ruptured 12.96 10.89 8 60272 480 46625302
Irritability 12.93 10.89 11 60269 28935 46596847
Electrocardiogram T wave alternans 12.90 10.89 4 60276 42 46625740
Tooth disorder 12.89 10.89 7 60273 23296 46602486
Anaphylactoid reaction 12.84 10.89 19 60261 3472 46622310
Periorbital cellulitis 12.78 10.89 8 60272 492 46625290
Patent ductus arteriosus 12.77 10.89 20 60260 3842 46621940
Enterococcal infection 12.74 10.89 28 60252 6959 46618823
Eosinophil cationic protein increased 12.73 10.89 4 60276 44 46625738
Arterial rupture 12.73 10.89 7 60273 338 46625444
Bronchial haemorrhage 12.73 10.89 7 60273 338 46625444
Paraesthesia 12.71 10.89 94 60186 117343 46508439
Eschar 12.71 10.89 8 60272 497 46625285
Vaginal haemorrhage 12.70 10.89 66 60214 25538 46600244
Vascular parkinsonism 12.69 10.89 5 60275 111 46625671
Umbilical cord vascular disorder 12.69 10.89 5 60275 111 46625671
Paralysis 12.69 10.89 32 60248 8689 46617093
Thoracic haemorrhage 12.65 10.89 4 60276 45 46625737
Paraparesis 12.60 10.89 14 60266 1925 46623857
Adrenomegaly 12.57 10.89 3 60277 10 46625772
Acne 12.53 10.89 5 60275 19914 46605868
Hospitalisation 12.52 10.89 41 60239 63344 46562438
Confusional state 12.50 10.89 139 60141 159753 46466029
Joint stiffness 12.48 10.89 10 60270 27098 46598684
Palpitations 12.46 10.89 72 60208 95187 46530595
Irritable bowel syndrome 12.44 10.89 3 60277 16512 46609270
Reperfusion injury 12.42 10.89 4 60276 48 46625734
Cardio-respiratory arrest 12.40 10.89 125 60155 59744 46566038
Pseudomonas infection 12.36 10.89 34 60246 9724 46616058
Abdominal pain upper 12.30 10.89 124 60156 145181 46480601
Reperfusion arrhythmia 12.27 10.89 4 60276 50 46625732
Protein S deficiency 12.27 10.89 4 60276 50 46625732
Colorectal cancer 12.24 10.89 10 60270 937 46624845
Gastrointestinal disorder 12.14 10.89 38 60242 59538 46566244
Dysgeusia 12.14 10.89 21 60259 40470 46585312
Pericarditis 12.09 10.89 8 60272 23919 46601863
Leukocytosis 12.08 10.89 61 60219 23337 46602445
Normal newborn 12.04 10.89 25 60255 5976 46619806
Peripheral embolism 11.92 10.89 11 60269 1213 46624569
Vascular malformation 11.92 10.89 5 60275 131 46625651
Device related thrombosis 11.90 10.89 11 60269 1216 46624566
Mental status changes 11.82 10.89 87 60193 38001 46587781
Klebsiella test positive 11.79 10.89 10 60270 987 46624795
Hot flush 11.78 10.89 24 60256 43493 46582289
Gallbladder disorder 11.67 10.89 4 60276 17494 46608288
Plantar erythema 11.55 10.89 6 60274 258 46625524
Therapeutic product effect increased 11.51 10.89 10 60270 1020 46624762
Foetal placental thrombosis 11.48 10.89 4 60276 62 46625720
Intracranial pressure increased 11.46 10.89 20 60260 4200 46621582
Vitreous haemorrhage 11.45 10.89 13 60267 1831 46623951
Pericardial effusion 11.42 10.89 64 60216 25479 46600303
Gestational hypertension 11.40 10.89 14 60266 2141 46623641
Gaze palsy 11.37 10.89 11 60269 1287 46624495
Musculoskeletal disorder 11.37 10.89 3 60277 15542 46610240
Budd-Chiari syndrome 11.36 10.89 4 60276 64 46625718
Blood phosphorus increased 11.33 10.89 16 60264 2803 46622979
Graft haemorrhage 11.29 10.89 3 60277 17 46625765
White blood cell count decreased 11.14 10.89 92 60188 112139 46513643
Cholestasis 11.12 10.89 66 60214 26827 46598955
Breast necrosis 11.11 10.89 5 60275 156 46625626
Hypovolaemia 11.11 10.89 33 60247 9855 46615927
Urticaria 11.09 10.89 98 60182 117794 46507988
Tracheal haemorrhage 11.05 10.89 5 60275 158 46625624
Mouth haemorrhage 11.04 10.89 25 60255 6337 46619445
Abortion early 11.01 10.89 3 60277 19 46625763
Extremity necrosis 10.98 10.89 12 60268 1621 46624161
Haemoglobin abnormal 10.98 10.89 20 60260 4343 46621439
Drug dependence 10.97 10.89 6 60274 19895 46605887
Ruptured cerebral aneurysm 10.96 10.89 7 60273 446 46625336
Vascular graft occlusion 10.93 10.89 5 60275 162 46625620
Wheezing 10.91 10.89 34 60246 53352 46572430
Apgar score low 10.89 10.89 8 60272 641 46625141

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heparin-induced thrombocytopenia 3749.43 11.02 1063 64110 4320 29882985
Fear 610.80 11.02 347 64826 10478 29876827
Renal injury 533.22 11.02 327 64846 11402 29875903
Injury 528.23 11.02 412 64761 21319 29865986
Thrombocytopenia 527.98 11.02 1013 64160 136031 29751274
Anhedonia 457.93 11.02 263 64910 8106 29879199
Emotional distress 418.37 11.02 315 64858 15450 29871855
Unevaluable event 366.75 11.02 397 64776 31388 29855917
Stress 301.15 11.02 290 64883 19945 29867360
Haemorrhage 281.25 11.02 419 64754 45660 29841645
Activated partial thromboplastin time prolonged 280.70 11.02 188 64985 7640 29879665
Multiple organ dysfunction syndrome 279.74 11.02 498 64675 62989 29824316
Renal failure 254.93 11.02 735 64438 128231 29759074
Vascular stent thrombosis 236.14 11.02 111 65062 2232 29885073
Post procedural haemorrhage 232.16 11.02 168 65005 7742 29879563
Haematoma 231.57 11.02 273 64900 23680 29863625
Thrombosis in device 226.05 11.02 123 65050 3403 29883902
Fatigue 217.56 11.02 227 64946 320446 29566859
Haemorrhage intracranial 198.70 11.02 202 64971 14830 29872475
Retroperitoneal haematoma 175.40 11.02 93 65080 2439 29884866
Cerebral haemorrhage 172.53 11.02 279 64894 32608 29854697
Labelled drug-drug interaction medication error 164.27 11.02 155 65018 10383 29876922
Cardiogenic shock 159.34 11.02 190 64983 16671 29870634
Cardiac tamponade 153.32 11.02 106 65067 4538 29882767
Retroperitoneal haemorrhage 150.28 11.02 86 65087 2629 29884676
Thrombosis 140.12 11.02 294 64879 41937 29845368
Drug abuse 139.97 11.02 10 65163 82062 29805243
Shock haemorrhagic 138.51 11.02 137 65036 9728 29877577
Pulmonary embolism 134.91 11.02 425 64748 77710 29809595
Coagulation time shortened 130.28 11.02 38 65135 173 29887132
Toxicity to various agents 126.02 11.02 120 65053 177063 29710242
Renal impairment 118.87 11.02 428 64745 83756 29803549
Weight decreased 117.23 11.02 94 65079 150827 29736478
Anxiety 114.47 11.02 442 64731 89429 29797876
Diarrhoea 112.90 11.02 363 64810 333740 29553565
Arthralgia 111.30 11.02 80 65093 135711 29751594
Heparin-induced thrombocytopenia test positive 103.76 11.02 25 65148 42 29887263
Deep vein thrombosis 103.38 11.02 328 64845 60173 29827132
Arterial thrombosis 101.24 11.02 53 65120 1353 29885952
Product dose omission issue 100.26 11.02 37 65136 91594 29795711
Catheter site haemorrhage 99.78 11.02 61 65112 2111 29885194
Coagulation time prolonged 98.92 11.02 50 65123 1184 29886121
Ventricular fibrillation 95.61 11.02 140 65033 14998 29872307
Dizziness 92.90 11.02 177 64996 194732 29692573
Intraventricular haemorrhage 90.37 11.02 65 65108 2965 29884340
Decreased appetite 88.54 11.02 118 65055 149792 29737513
Asthenia 86.59 11.02 224 64949 221066 29666239
Heparin-induced thrombocytopenia test 85.85 11.02 25 65148 113 29887192
Haemoglobin decreased 83.82 11.02 478 64695 113620 29773685
Hypotension 82.64 11.02 730 64443 199835 29687470
Procedural complication 81.51 11.02 72 65101 4425 29882880
Heparin resistance 80.97 11.02 18 65155 16 29887289
Post procedural complication 77.77 11.02 111 65062 11615 29875690
Pulmonary haemorrhage 77.69 11.02 99 65074 9293 29878012
Coronary artery thrombosis 77.62 11.02 52 65121 2112 29885193
Subarachnoid haemorrhage 76.76 11.02 101 65072 9785 29877520
Malaise 75.75 11.02 156 65017 166806 29720499
Coagulation time abnormal 75.17 11.02 24 65149 156 29887149
Insomnia 75.11 11.02 56 65117 93280 29794025
Ventricular tachycardia 74.35 11.02 162 65011 23700 29863605
Brain herniation 74.10 11.02 63 65110 3677 29883628
Psoriasis 72.96 11.02 5 65168 42501 29844804
Venous thrombosis 71.40 11.02 58 65115 3176 29884129
Antibody test positive 71.36 11.02 33 65140 638 29886667
Joint swelling 71.35 11.02 9 65164 46937 29840368
Muscle haemorrhage 70.56 11.02 61 65112 3642 29883663
Fall 70.40 11.02 185 64988 181687 29705618
Pulmonary alveolar haemorrhage 68.57 11.02 78 65095 6503 29880802
Intentional overdose 68.05 11.02 6 65167 41475 29845830
Disseminated intravascular coagulation 67.35 11.02 149 65024 22022 29865283
Compartment syndrome 65.89 11.02 50 65123 2477 29884828
Cardiac arrest 65.55 11.02 385 64788 92465 29794840
Septic shock 63.84 11.02 291 64882 63316 29823989
Suicidal ideation 62.71 11.02 4 65169 36110 29851195
Pulseless electrical activity 62.22 11.02 72 65101 6115 29881190
Pericardial haemorrhage 61.62 11.02 51 65122 2867 29884438
Coagulation time 61.59 11.02 12 65161 0 29887305
Suicide attempt 61.04 11.02 5 65168 36692 29850613
Weight increased 60.19 11.02 45 65128 74868 29812437
Haemodynamic instability 59.33 11.02 80 65093 7935 29879370
Product contamination 57.06 11.02 28 65145 621 29886684
Intra-abdominal haemorrhage 55.71 11.02 42 65131 2060 29885245
Dehydration 55.50 11.02 116 65057 123423 29763882
Myalgia 54.31 11.02 52 65121 76615 29810690
Pharyngeal haemorrhage 52.23 11.02 27 65146 671 29886634
Intracardiac thrombus 52.14 11.02 43 65130 2405 29884900
Muscle spasms 52.02 11.02 39 65134 64799 29822506
Procedural haemorrhage 51.76 11.02 42 65131 2296 29885009
Myocardial rupture 50.62 11.02 18 65155 169 29887136
Peripheral ischaemia 50.19 11.02 60 65113 5274 29882031
Low birth weight baby 50.18 11.02 64 65109 6012 29881293
Nasopharyngitis 49.03 11.02 34 65139 58815 29828490
Product measured potency issue 48.14 11.02 15 65158 89 29887216
Fear of death 47.94 11.02 25 65148 633 29886672
Nausea 47.37 11.02 416 64757 296541 29590764
Vascular pseudoaneurysm 46.55 11.02 37 65136 1963 29885342
Extraocular muscle disorder 46.08 11.02 17 65156 179 29887126
Gait disturbance 46.01 11.02 57 65116 74720 29812585
Somnolence 45.89 11.02 88 65085 96675 29790630
Product administration error 45.22 11.02 98 65075 14279 29873026
Coagulopathy 45.02 11.02 114 65059 18373 29868932
Peripheral swelling 44.93 11.02 40 65133 61034 29826271
Respiratory failure 44.82 11.02 373 64800 100269 29787036
Pain 44.47 11.02 572 64601 172069 29715236
Coagulation test abnormal 44.18 11.02 21 65152 433 29886872
Haematuria 44.14 11.02 204 64969 44630 29842675
Neuropathy peripheral 44.12 11.02 53 65120 70422 29816883
Anti-platelet antibody positive 43.81 11.02 18 65155 258 29887047
Cardiac ventricular thrombosis 43.45 11.02 25 65148 772 29886533
Unresponsive to stimuli 43.05 11.02 141 65032 26278 29861027
Retinal pigment epitheliopathy 43.01 11.02 17 65156 219 29887086
Adrenal haemorrhage 42.59 11.02 16 65157 178 29887127
Skin necrosis 42.57 11.02 52 65121 4675 29882630
Drug intolerance 42.13 11.02 23 65150 45268 29842037
Gastrointestinal haemorrhage 41.93 11.02 318 64855 83128 29804177
Aggression 41.88 11.02 14 65159 36893 29850412
Electrocardiogram ST segment elevation 41.85 11.02 50 65123 4392 29882913
Post procedural haematoma 41.20 11.02 31 65142 1516 29885789
Acute respiratory distress syndrome 40.72 11.02 128 65045 23344 29863961
Puncture site haemorrhage 40.09 11.02 18 65155 324 29886981
Musculoskeletal stiffness 40.04 11.02 14 65159 35867 29851438
Arterial haemorrhage 39.15 11.02 23 65150 739 29886566
Sepsis 38.93 11.02 488 64685 145907 29741398
Aortic thrombosis 38.72 11.02 22 65151 663 29886642
Rash 38.50 11.02 252 64921 191637 29695668
Feeling abnormal 38.46 11.02 40 65133 56716 29830589
Brain oedema 38.41 11.02 84 65089 12314 29874991
Cardiac procedure complication 38.10 11.02 16 65157 243 29887062
Atrial thrombosis 37.91 11.02 32 65141 1849 29885456
Coronary artery perforation 37.72 11.02 11 65162 50 29887255
Procedural hypotension 37.65 11.02 25 65148 1000 29886305
Memory impairment 37.40 11.02 17 65156 37157 29850148
Peripheral artery thrombosis 37.03 11.02 34 65139 2198 29885107
Haemothorax 36.86 11.02 42 65131 3507 29883798
Acute kidney injury 36.80 11.02 816 64357 273026 29614279
Dyspnoea 36.74 11.02 508 64665 332787 29554518
Balance disorder 36.23 11.02 17 65156 36476 29850829
Intentional product misuse 36.23 11.02 15 65158 34652 29852653
Asthma 35.69 11.02 17 65156 36157 29851148
Graft thrombosis 35.64 11.02 16 65157 288 29887017
Intestinal ischaemia 35.43 11.02 58 65115 6839 29880466
Appendicolith 35.18 11.02 23 65150 896 29886409
Influenza 34.93 11.02 26 65147 43372 29843933
Cough 34.07 11.02 149 65024 125493 29761812
Gangrene 34.07 11.02 46 65127 4568 29882737
Overdose 33.94 11.02 84 65089 84253 29803052
Cerebral infarction 33.73 11.02 130 65043 26243 29861062
Catheter site haematoma 33.64 11.02 13 65160 157 29887148
Injection site pain 33.53 11.02 12 65161 30298 29857007
Shock 32.85 11.02 117 65056 22742 29864563
Acute myocardial infarction 32.58 11.02 212 64961 52727 29834578
Torsade de pointes 32.36 11.02 57 65116 7133 29880172
Death 32.12 11.02 566 64607 356717 29530588
Headache 31.89 11.02 249 64924 182057 29705248
Hallucination 31.66 11.02 36 65137 49023 29838282
Haemorrhagic transformation stroke 31.48 11.02 24 65149 1197 29886108
Activated partial thromboplastin time shortened 31.08 11.02 16 65157 394 29886911
Alopecia 31.04 11.02 3 65170 19272 29868033
Hereditary angioedema 30.92 11.02 20 65153 765 29886540
Haemorrhagic cerebral infarction 30.90 11.02 20 65153 766 29886539
Embolism 30.81 11.02 55 65118 6954 29880351
Antiphospholipid syndrome 30.65 11.02 16 65157 406 29886899
Incision site pain 30.31 11.02 29 65144 1975 29885330
Pain in extremity 30.31 11.02 130 65043 110091 29777214
Gastric haemorrhage 30.31 11.02 65 65108 9402 29877903
Hospitalisation 30.29 11.02 31 65142 44288 29843017
Suspected product quality issue 29.85 11.02 12 65161 162 29887143
Irritability 29.38 11.02 7 65166 23043 29864262
Blood pressure decreased 29.26 11.02 189 64984 46886 29840419
Abdominal discomfort 29.16 11.02 38 65135 48753 29838552
Haemorrhagic infarction 29.04 11.02 15 65158 372 29886933
Vascular stent occlusion 28.84 11.02 11 65162 128 29887177
Kounis syndrome 28.76 11.02 26 65147 1647 29885658
Pulmonary haematoma 28.39 11.02 9 65164 57 29887248
Platelet count decreased 28.27 11.02 354 64819 105775 29781530
Herpes zoster 28.14 11.02 15 65158 29928 29857377
Drug dependence 28.08 11.02 6 65167 21289 29866016
Cerebral reperfusion injury 27.74 11.02 6 65167 4 29887301
Vena cava thrombosis 27.73 11.02 21 65152 1037 29886268
Extradural haematoma 27.68 11.02 22 65151 1167 29886138
Haemoptysis 27.39 11.02 137 65036 30941 29856364
Mediastinal haematoma 27.30 11.02 10 65163 103 29887202
Premature baby 27.11 11.02 89 65084 16602 29870703
Arthropathy 27.01 11.02 6 65167 20721 29866584
Haematocrit decreased 26.82 11.02 135 65038 30564 29856741
Respiratory distress 26.73 11.02 142 65031 32830 29854475
Vertigo 26.72 11.02 8 65165 22627 29864678
Complication associated with device 26.59 11.02 46 65127 5674 29881631
Pulmonary artery thrombosis 26.45 11.02 17 65156 643 29886662
Ischaemic hepatitis 26.35 11.02 24 65149 1535 29885770
Organ failure 26.34 11.02 28 65145 2163 29885142
Leg amputation 26.24 11.02 28 65145 2173 29885132
Livedo reticularis 26.21 11.02 28 65145 2176 29885129
Lymphocyte count decreased 26.08 11.02 96 65077 18959 29868346
Malignant neoplasm progression 26.06 11.02 76 65097 72211 29815094
Choroidal dystrophy 26.03 11.02 8 65165 45 29887260
Activated partial thromboplastin time abnormal 25.74 11.02 9 65164 80 29887225
Haemoperitoneum 25.64 11.02 23 65150 1442 29885863
Aneurysm ruptured 25.61 11.02 15 65158 479 29886826
Device related thrombosis 25.61 11.02 18 65155 791 29886514
Haematoma muscle 25.60 11.02 16 65157 576 29886729
Vision blurred 25.57 11.02 32 65141 41784 29845521
Choroidal infarction 25.26 11.02 9 65164 85 29887220
Hypercoagulation 25.26 11.02 20 65153 1055 29886250
Reperfusion injury 25.17 11.02 9 65164 86 29887219
Vasodilatation 25.13 11.02 19 65154 936 29886369
Palpitations 24.67 11.02 22 65151 33551 29853754
Hypertransaminasaemia 24.62 11.02 36 65137 3849 29883456
Tongue haematoma 24.49 11.02 10 65163 141 29887164
Acute right ventricular failure 24.38 11.02 9 65164 95 29887210
Ventricular extrasystoles 24.12 11.02 67 65106 11407 29875898
Prostate cancer 24.03 11.02 11 65162 23946 29863359
Disease progression 23.97 11.02 91 65082 79783 29807522
Red blood cells urine positive 23.70 11.02 23 65150 1594 29885711
Embolic stroke 23.59 11.02 34 65139 3588 29883717
Haemolysis 23.55 11.02 50 65123 7181 29880124
Sleep disorder 23.39 11.02 12 65161 24467 29862838
Psychotic disorder 22.98 11.02 9 65164 21506 29865799
Dyspnoea exertional 22.85 11.02 26 65147 35404 29851901
Tremor 22.52 11.02 86 65087 75277 29812028
Abnormal behaviour 22.42 11.02 14 65159 25609 29861696
Basal cell carcinoma 22.30 11.02 4 65169 16064 29871241
Coronary artery stenosis 22.15 11.02 56 65117 9014 29878291
Jugular vein thrombosis 22.14 11.02 21 65152 1415 29885890
Spinal epidural haematoma 22.07 11.02 10 65163 184 29887121
Cognitive disorder 22.07 11.02 12 65161 23678 29863627
Treatment noncompliance 21.82 11.02 14 65159 25239 29862066
Plasma cell myeloma 21.69 11.02 53 65120 53409 29833896
Inappropriate schedule of product administration 21.69 11.02 33 65140 39695 29847610
Full blood count decreased 21.62 11.02 4 65169 15713 29871592
Lower respiratory tract infection 21.50 11.02 16 65157 26698 29860607
Visual impairment 21.12 11.02 21 65152 30417 29856888
Dysgeusia 21.09 11.02 14 65159 24787 29862518
Wrong technique in product usage process 21.05 11.02 22 65151 31133 29856172
Blood pressure fluctuation 21.00 11.02 6 65167 17497 29869808
Abdominal pain upper 20.95 11.02 68 65105 62483 29824822
Suspected transmission of an infectious agent via product 20.93 11.02 13 65160 463 29886842
Vessel puncture site haematoma 20.89 11.02 7 65166 54 29887251
Osteoarthritis 20.75 11.02 7 65166 18342 29868963
Coronary artery embolism 20.62 11.02 9 65164 151 29887154
Haemorrhagic stroke 20.60 11.02 43 65130 6104 29881201
Cerebral haematoma 20.59 11.02 36 65137 4478 29882827
Platelet factor 4 increased 20.53 11.02 4 65169 0 29887305
Confusional state 20.49 11.02 191 64982 134643 29752662
Intrapericardial thrombosis 20.46 11.02 7 65166 58 29887247
Arthritis 20.44 11.02 14 65159 24387 29862918
Renal infarct 20.31 11.02 18 65155 1111 29886194
Prothrombin time prolonged 20.23 11.02 55 65118 9248 29878057
Road traffic accident 20.21 11.02 6 65167 17065 29870240
Oedema peripheral 20.18 11.02 141 65032 105691 29781614
Peripheral artery occlusion 20.14 11.02 20 65153 1426 29885879
Blood urea increased 20.12 11.02 127 65046 31254 29856051
Rhinorrhoea 20.09 11.02 10 65163 20744 29866561
Respiratory tract oedema 20.00 11.02 12 65161 401 29886904
Renal artery thrombosis 19.90 11.02 11 65162 314 29886991
Influenza like illness 19.76 11.02 16 65157 25589 29861716
Eosinophilia 19.74 11.02 98 65075 22062 29865243
Product quality issue 19.64 11.02 87 65086 18687 29868618
Intentional self-injury 19.60 11.02 3 65170 13529 29873776
Abdominal wall haematoma 19.57 11.02 21 65152 1640 29885665
Haematemesis 19.33 11.02 110 65063 26093 29861212
Wound evisceration 19.32 11.02 8 65165 117 29887188
Budd-Chiari syndrome 19.29 11.02 5 65168 13 29887292
Tracheal haemorrhage 19.28 11.02 12 65161 429 29886876
Reperfusion arrhythmia 19.21 11.02 7 65166 71 29887234
Psychological trauma 19.09 11.02 9 65164 182 29887123
Mouth haemorrhage 19.09 11.02 37 65136 4980 29882325
Platelet disorder 19.09 11.02 18 65155 1204 29886101
Prosthetic cardiac valve thrombosis 19.02 11.02 5 65168 14 29887291
Paraesthesia 18.94 11.02 58 65115 54269 29833036
Petechiae 18.88 11.02 53 65120 9078 29878227
Device related sepsis 18.87 11.02 24 65149 2248 29885057
Product complaint 18.74 11.02 40 65133 5766 29881539
Loss of personal independence in daily activities 18.52 11.02 12 65161 21523 29865782
Drug withdrawal syndrome 18.50 11.02 10 65163 19799 29867506
Cerebral hyperperfusion syndrome 18.38 11.02 7 65166 81 29887224
Hypoxic-ischaemic encephalopathy 18.36 11.02 35 65138 4652 29882653
Appendicitis 18.32 11.02 41 65132 6103 29881202
Hydrocephalus 18.31 11.02 33 65140 4204 29883101
Hand amputation 18.30 11.02 4 65169 3 29887302
Haemorrhage coronary artery 18.29 11.02 5 65168 17 29887288
Pulmonary fibrosis 18.07 11.02 6 65167 15884 29871421
Mixed liver injury 18.07 11.02 22 65151 1971 29885334
Osteonecrosis of jaw 17.98 11.02 9 65164 18609 29868696
White blood cell count decreased 17.95 11.02 108 65065 83839 29803466
Vomiting 17.89 11.02 354 64819 219464 29667841
Vascular access site haematoma 17.77 11.02 4 65169 4 29887301
Intra-abdominal haematoma 17.75 11.02 18 65155 1316 29885989
Pruritus 17.71 11.02 168 65005 118036 29769269
Platelet aggregation abnormal 17.66 11.02 5 65168 20 29887285
Aplastic anaemia 17.62 11.02 38 65135 5518 29881787
Nikolsky's sign 17.51 11.02 9 65164 221 29887084
Gastrooesophageal reflux disease 17.41 11.02 27 65146 32228 29855077
Ventricular asystole 17.33 11.02 8 65165 154 29887151
Microstomia 17.30 11.02 4 65169 5 29887300
Foetal exposure timing unspecified 17.25 11.02 9 65164 228 29887077
Necrosis ischaemic 17.22 11.02 9 65164 229 29887076
Hemiplegia 17.19 11.02 42 65131 6619 29880686
Pneumonia 17.16 11.02 576 64597 333730 29553575
Back pain 17.05 11.02 142 65031 102454 29784851
Peliosis hepatis 17 11.02 6 65167 55 29887250
Anticoagulation drug level below therapeutic 16.99 11.02 13 65160 652 29886653
Drug reaction with eosinophilia and systemic symptoms 16.86 11.02 113 65060 28375 29858930
Thrombotic microangiopathy 16.85 11.02 49 65124 8561 29878744
Head injury 16.78 11.02 8 65165 17012 29870293
Nightmare 16.77 11.02 3 65170 12073 29875232
Coronary artery dissection 16.61 11.02 8 65165 170 29887135
Medical device site thrombosis 16.60 11.02 5 65168 26 29887279
Hemiparesis 16.56 11.02 70 65103 14732 29872573
Subcutaneous haematoma 16.56 11.02 15 65158 953 29886352
Nasal congestion 16.44 11.02 10 65163 18556 29868749
Cataract 16.41 11.02 14 65159 21821 29865484
Rash maculo-papular 16.37 11.02 103 65070 25315 29861990
Incorrect drug administration rate 16.36 11.02 16 65157 1120 29886185
Subdural haematoma 16.27 11.02 83 65090 18889 29868416
Eye excision 16.14 11.02 5 65168 29 29887276
Contrast media reaction 16.06 11.02 14 65159 845 29886460
Foot amputation 16.05 11.02 11 65162 464 29886841
Gastrointestinal necrosis 16.01 11.02 27 65146 3262 29884043
Blood culture positive 16.01 11.02 34 65139 4885 29882420
Bronchial haemorrhage 15.93 11.02 13 65160 716 29886589
Therapeutic product effect decreased 15.83 11.02 113 65060 28963 29858342
Therapeutic product effect incomplete 15.82 11.02 31 65142 33803 29853502
Penile necrosis 15.79 11.02 6 65167 69 29887236
Hepatic haematoma 15.78 11.02 11 65162 477 29886828
Erectile dysfunction 15.69 11.02 10 65163 18092 29869213
Dry mouth 15.59 11.02 16 65157 22834 29864471
Coronary artery aneurysm 15.49 11.02 6 65167 73 29887232
Constipation 15.45 11.02 164 65009 112742 29774563
Bullous haemorrhagic dermatosis 15.40 11.02 3 65170 0 29887305
Anisochromia 15.40 11.02 3 65170 0 29887305
Autoimmune heparin-induced thrombocytopenia 15.40 11.02 3 65170 0 29887305
Acquired antithrombin III deficiency 15.40 11.02 3 65170 0 29887305
Chest wall haematoma 15.30 11.02 7 65166 132 29887173
Osteonecrosis 15.28 11.02 8 65165 16127 29871178
Fat embolism 15.18 11.02 8 65165 207 29887098
Drug ineffective 15.09 11.02 597 64576 339790 29547515
Right ventricular failure 15.03 11.02 45 65128 7991 29879314
Orthostatic hypotension 15.03 11.02 18 65155 23961 29863344
Continuous haemodiafiltration 14.91 11.02 15 65158 1086 29886219
Traumatic liver injury 14.81 11.02 8 65165 218 29887087
Thyroid haemorrhage 14.77 11.02 4 65169 13 29887292
Myiasis 14.77 11.02 4 65169 13 29887292
Interstitial lung disease 14.75 11.02 74 65099 60123 29827182
Hypoxia 14.65 11.02 164 65009 47690 29839615
Delusion 14.59 11.02 4 65169 11985 29875320
Mean cell haemoglobin concentration 14.55 11.02 5 65168 42 29887263
Primary adrenal insufficiency 14.54 11.02 4 65169 14 29887291
Incision site haematoma 14.54 11.02 6 65167 87 29887218
Poor quality product administered 14.45 11.02 18 65155 1651 29885654
Serratia infection 14.41 11.02 12 65161 680 29886625
Mean arterial pressure decreased 14.40 11.02 7 65166 152 29887153
Fluid retention 14.39 11.02 20 65153 24978 29862327
Diabetes mellitus 14.38 11.02 45 65128 41820 29845485
Syncope 14.33 11.02 117 65056 84786 29802519
Coronary bypass thrombosis 14.33 11.02 4 65169 15 29887290
Foetal growth restriction 14.33 11.02 27 65146 3558 29883747
Hot flush 14.32 11.02 7 65166 14673 29872632
Coronary artery occlusion 14.26 11.02 55 65118 11102 29876203
Brain death 14.14 11.02 22 65151 2484 29884821
Device occlusion 14.13 11.02 37 65136 6083 29881222
Urea renal clearance decreased 14.13 11.02 4 65169 16 29887289
Complications of transplanted kidney 14.11 11.02 29 65144 4072 29883233
Fungal sepsis 13.99 11.02 12 65161 709 29886596
Depressed mood 13.96 11.02 10 65163 17019 29870286
Dialysis 13.89 11.02 54 65119 10942 29876363
Tinnitus 13.79 11.02 9 65164 16079 29871226
Antithrombin III deficiency 13.78 11.02 6 65167 100 29887205
Blood creatine phosphokinase MB increased 13.68 11.02 19 65154 1937 29885368
Monoplegia 13.56 11.02 16 65157 1387 29885918
Visual acuity reduced 13.40 11.02 9 65164 15837 29871468
Anticoagulation drug level above therapeutic 13.38 11.02 18 65155 1781 29885524
Platelet aggregation test 13.36 11.02 5 65168 55 29887250
Bone pain 13.35 11.02 13 65160 19013 29868292
Hepatitis C 13.34 11.02 6 65167 13199 29874106
Heart rate irregular 13.31 11.02 5 65168 12254 29875051
Cerebral artery occlusion 13.28 11.02 12 65161 760 29886545
Renal tubular necrosis 13.27 11.02 67 65106 15184 29872121
Venous thrombosis limb 13.26 11.02 18 65155 1796 29885509
Withdrawal syndrome 13.24 11.02 4 65169 11246 29876059
Palmar-plantar erythrodysaesthesia syndrome 13.18 11.02 8 65165 14862 29872443
Aortic dissection 13.18 11.02 21 65152 2421 29884884
Ischaemic stroke 13.12 11.02 70 65103 16205 29871100
Finger amputation 13.08 11.02 7 65166 187 29887118
Distributive shock 13.04 11.02 11 65162 635 29886670
Accidental exposure to product 13.03 11.02 3 65170 10112 29877193
Epistaxis 12.94 11.02 174 64999 52807 29834498
Hypertension 12.93 11.02 186 64987 121168 29766137
Chronic obstructive pulmonary disease 12.91 11.02 54 65119 46072 29841233
Arterial injury 12.80 11.02 8 65165 288 29887017
Metastases to liver 12.79 11.02 5 65168 11960 29875345
Sopor 12.77 11.02 4 65169 10987 29876318
Renal haemorrhage 12.71 11.02 15 65158 1300 29886005
Pulmonary oedema 12.70 11.02 149 65024 43826 29843479
Acute respiratory failure 12.67 11.02 98 65075 25752 29861553
Ecchymosis 12.65 11.02 37 65136 6485 29880820
Pericardial effusion 12.59 11.02 84 65089 21060 29866245
Pulse absent 12.55 11.02 33 65140 5440 29881865
Type 2 diabetes mellitus 12.54 11.02 7 65166 13615 29873690
Cerebral venous sinus thrombosis 12.48 11.02 8 65165 301 29887004
Respiratory gas exchange disorder 12.46 11.02 9 65164 413 29886892
Necrotising oesophagitis 12.42 11.02 9 65164 415 29886890
Hallucination, auditory 12.42 11.02 3 65170 9786 29877519
Neutrophil count increased 12.42 11.02 66 65107 15257 29872048
Carotid artery dissection 12.40 11.02 6 65167 129 29887176
Agitation 12.39 11.02 68 65105 54005 29833300
Hepatic cirrhosis 12.34 11.02 10 65163 15989 29871316
Alveolitis necrotising 12.27 11.02 4 65169 28 29887277
Venous haemorrhage 12.27 11.02 4 65169 28 29887277
Atrial fibrillation 12.25 11.02 315 64858 107809 29779496
Cyanosis 12.25 11.02 55 65118 11880 29875425
Immune effector cell-associated neurotoxicity syndrome 12.22 11.02 12 65161 844 29886461
Ischaemia 12.19 11.02 29 65144 4492 29882813
Blood pressure increased 12.19 11.02 99 65074 71829 29815476
Bronchitis 12.10 11.02 44 65129 39081 29848224
Haemodialysis 12.10 11.02 52 65121 11021 29876284
Graft loss 12.06 11.02 12 65161 858 29886447
Bradycardia 12.05 11.02 205 64968 65321 29821984
Haemorrhagic disorder 12.04 11.02 10 65163 565 29886740
Apgar score abnormal 12.04 11.02 4 65169 30 29887275
Hypoacusis 11.99 11.02 8 65165 14131 29873174
Retinoblastoma 11.92 11.02 4 65169 31 29887274
International normalised ratio decreased 11.90 11.02 29 65144 4561 29882744
Myelodysplastic syndrome 11.87 11.02 14 65159 18764 29868541
Cerebrovascular accident 11.86 11.02 251 64922 83226 29804079
Iliac artery occlusion 11.83 11.02 6 65167 143 29887162
Anti factor Xa activity decreased 11.80 11.02 3 65170 7 29887298
Burkholderia test positive 11.79 11.02 9 65164 450 29886855
Electrocardiogram ST segment abnormal 11.78 11.02 10 65163 582 29886723
Hypovolaemic shock 11.78 11.02 36 65137 6464 29880841
Diabetes insipidus 11.73 11.02 19 65154 2220 29885085
Peritoneal dialysis complication 11.71 11.02 27 65146 4100 29883205
Peripheral arterial occlusive disease 11.68 11.02 31 65142 5137 29882168
Amnesia 11.62 11.02 22 65151 24299 29863006
Neuroleptic malignant syndrome 11.59 11.02 11 65162 16284 29871021
Therapeutic product ineffective 11.57 11.02 10 65163 597 29886708
Iatrogenic injury 11.56 11.02 11 65162 744 29886561
Tachycardia 11.56 11.02 225 64948 73514 29813791
Cerebral artery embolism 11.56 11.02 12 65161 902 29886403
Disability 11.55 11.02 28 65145 4390 29882915
Splenic haematoma 11.54 11.02 6 65167 151 29887154
Injection site erythema 11.50 11.02 8 65165 13826 29873479
Vessel puncture site haemorrhage 11.50 11.02 5 65168 83 29887222
Inferior vena caval occlusion 11.50 11.02 4 65169 35 29887270
Transplant failure 11.46 11.02 20 65153 2484 29884821
Atelectasis 11.41 11.02 67 65106 16071 29871234
Cardiac perforation 11.40 11.02 5 65168 85 29887220
Nephrolithiasis 11.37 11.02 23 65150 24787 29862518
Localised infection 11.35 11.02 8 65165 13729 29873576
Pollakiuria 11.35 11.02 12 65161 16894 29870411
Paranoia 11.32 11.02 4 65169 10184 29877121
Melaena 11.25 11.02 114 65059 32323 29854982
Dermatitis bullous 11.24 11.02 34 65139 6070 29881235
Brain stem infarction 11.17 11.02 14 65159 1292 29886013
Protein urine present 11.16 11.02 29 65144 4746 29882559
Contrast encephalopathy 11.12 11.02 4 65169 39 29887266
Neonatal respiratory distress syndrome 11.11 11.02 26 65147 3986 29883319
Product prescribing error 11.10 11.02 12 65161 16721 29870584
Upper gastrointestinal haemorrhage 11.07 11.02 84 65089 21944 29865361
Haemodialysis complication 11.04 11.02 5 65168 92 29887213

Pharmacologic Action:

SourceCodeDescription
ATC B01AB01 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Heparin group
ATC C05BA03 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
ANTIVARICOSE THERAPY
Heparins or heparinoids for topical use
ATC S01XA14 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
ATC B01AB51 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Heparin group
ATC C05BA53 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
ANTIVARICOSE THERAPY
Heparins or heparinoids for topical use
FDA CS M0010187 Heparin
FDA EPC N0000175474 Unfractionated Heparin
MeSH PA D000925 Anticoagulants
MeSH PA D002317 Cardiovascular Agents
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
FDA EPC N0000175980 Anti-coagulant
CHEBI has role CHEBI:50249 anticoagulante

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Disseminated intravascular coagulation indication 67406007 DOID:11247
Deep venous thrombosis indication 128053003
Pulmonary thromboembolism indication 233935004
Peripheral arterial embolism indication 286959000
Non-Q wave myocardial infarction indication 314207007
Prevention of deep vein thrombosis indication 439993001
Deep Vein Thrombosis with Pulmonary Embolism indication
Prevention of Recurrent Venous Thrombosis Associated with Malignancy indication
Pulmonary Thromboembolism Prevention indication
Peripheral Arterial Thromboembolism Prevention indication
Maintain Patency of Indwelling Vascular Catheter indication
Prevention of Ischemic Complications of Non-Q Wave MI indication
Prevention of Cardiac Ischemia in Unstable Angina indication
Myocardial infarction off-label use 22298006 DOID:5844
Coronavirus infection off-label use 186747009
Acute coronary syndrome off-label use 394659003
Percutaneous coronary intervention off-label use 415070008
Intracranial hemorrhage contraindication 1386000
Diabetic retinopathy contraindication 4855003 DOID:8947
Hypertensive retinopathy contraindication 6962006 DOID:11561
Retinal disorder contraindication 29555009 DOID:5679
Antithrombin III deficiency contraindication 36351005 DOID:3755
Gastrointestinal ulcer contraindication 40845000
Threatened abortion contraindication 54048003 DOID:9667
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Osteoporosis contraindication 64859006 DOID:11476
Operation on brain contraindication 70586009
Heparin-induced thrombocytopenia contraindication 73397007
Gastrointestinal hemorrhage contraindication 74474003
Ulceration of intestine contraindication 85942002
Acute gastric ulcer with hemorrhage contraindication 89748001
Hemophilia contraindication 90935002
Disorder of biliary tract contraindication 105997008 DOID:9741
Procedure on central nervous system contraindication 118679007
Bleeding contraindication 131148009
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Hemorrhagic cerebral infarction contraindication 230706003
Local anesthetic intrathecal block contraindication 231249005
Infective endocarditis contraindication 233850007
Procedure on spine contraindication 238181003
Qualitative platelet disorder contraindication 267532001
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral hemorrhage contraindication 274100004
Lumbar puncture contraindication 277762005
Bacterial endocarditis contraindication 301183007
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Dissection of aorta contraindication 308546005
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Surgical procedure on eye proper contraindication 373353005
Hypertensive urgency contraindication 443482000
Placement of Epidural Catheter contraindication
Thrombosis in Heparin Induced Thrombocytopenia contraindication
Platelet Aggregation Inhibition contraindication
Spinal Epidural Hematoma contraindication
Significant Bleeding contraindication
Indwelling Vascular Catheter contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Antithrombin-III Secreted ACTIVATOR Kd 7.85 IUPHAR CHEMBL

External reference:

IDSource
D02112 KEGG_DRUG
37270-89-6 SECONDARY_CAS_RN
4017546 VANDF
4017547 VANDF
4017549 VANDF
4018538 VANDF
C0019134 UMLSCUI
CHEBI:28304 CHEBI
M7J PDB_CHEM_ID
CHEMBL1909300 ChEMBL_ID
CHEMBL1201513 ChEMBL_ID
CHEMBL1201657 ChEMBL_ID
DB01109 DRUGBANK_ID
D006493 MESH_DESCRIPTOR_UI
4214 IUPHAR_LIGAND_ID
392 INN_ID
T2410KM04A UNII
772 PUBCHEM_CID
20044 RXNORM
3649 MMSL
4821 MMSL
d00252 MMSL
002079 NDDF
002081 NDDF
015153 NDDF
29725000 SNOMEDCT_US
372877000 SNOMEDCT_US
412201008 SNOMEDCT_US
412401006 SNOMEDCT_US
50045009 SNOMEDCT_US
784398008 SNOMEDCT_US
84812008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0043 INJECTION 1000 [USPU] INTRAVENOUS NDA 26 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0058 INJECTION 1000 [USPU] INTRAVENOUS NDA 26 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0059 INJECTION 5000 [USPU] INTRAVENOUS NDA 26 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0062 INJECTION 10000 [USPU] INTRAVENOUS NDA 26 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0137 INJECTION 1000 [USPU] INTRAVENOUS NDA 26 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0264-5705 INJECTION 5000 [USPU] INTRAVENOUS ANDA 20 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9567 INJECTION 4000 [USPU] INTRAVENOUS NDA 19 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9577 INJECTION 5000 [USPU] INTRAVENOUS NDA 19 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9587 INJECTION 10000 [USPU] INTRAVENOUS NDA 19 sections
Heparin Sodium in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-9872 INJECTION 200 [USPU] INTRAVENOUS NDA 23 sections
HEPARIN SODIUM IN SODIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0424 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA authorized generic 25 sections
HEPARIN SODIUM IN SODIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0428 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA 25 sections
HEPARIN SODIUM IN SODIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0431 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA 25 sections
HEPARIN SODIUM IN SODIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0433 INJECTION, SOLUTION 200 [USPU] INTRAVESICAL NDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-1316 INJECTION, SOLUTION 10000 [USPU] SUBCUTANEOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-1402 INJECTION, SOLUTION 5000 [USPU] SUBCUTANEOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-2720 INJECTION, SOLUTION 1000 [USPU] SUBCUTANEOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-2721 INJECTION, SOLUTION 10000 [USPU] INTRAVENOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-2723 INJECTION, SOLUTION 5000 [USPU] SUBCUTANEOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7620 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA 27 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7650 INJECTION, SOLUTION 10000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7651 INJECTION, SOLUTION 5000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium and Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0409-7793 INJECTION, SOLUTION 10000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium and Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0409-7794 INJECTION, SOLUTION 5000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0391 INJECTION 1000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0400 INJECTION 5000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0410 INJECTION 10000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-2450 INJECTION 1000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-2460 INJECTION 5000 [USPU] INTRAVENOUS NDA 24 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-6199 INJECTION 5000 [USPU] INTRAVENOUS NDA 24 sections