heparin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
heparin derivatives including low molecular mass heparins	1358	9005-49-6

Description:

Molecule

Description

Synonyms: heparin heparin sodium heparin calcium

A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
10	TU	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 9, 1939	FDA	ORGANON USA INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heparin-induced thrombocytopenia	2864.45	10.89	735	59545	3574	46622208
Renal injury	315.28	10.89	180	60100	9361	46616421
Fear	295.92	10.89	210	60070	15962	46609820
Activated partial thromboplastin time prolonged	274.38	10.89	147	60133	6742	46619040
Haemorrhage	267.87	10.89	342	59938	54527	46571255
Rheumatoid arthritis	256.66	10.89	13	60267	240202	46385580
Multiple organ dysfunction syndrome	251.93	10.89	322	59958	51388	46574394
Anhedonia	246.02	10.89	158	60122	10177	46615605
Renal failure	245.07	10.89	487	59793	113107	46512675
Thrombocytopenia	237.10	10.89	512	59768	126069	46499713
Retroperitoneal haemorrhage	234.79	10.89	99	60181	2631	46623151
Shock haemorrhagic	215.61	10.89	136	60144	8488	46617294
Thrombosis in device	210.35	10.89	94	60186	2885	46622897
Cerebral haemorrhage	204.16	10.89	216	60064	28155	46597627
Maternal exposure during pregnancy	203.75	10.89	425	59855	102124	46523658
Injury	203.23	10.89	267	60013	43760	46582022
Haemorrhage intracranial	202.76	10.89	152	60128	12572	46613210
Premature delivery	182.32	10.89	181	60099	21888	46603894
Pulmonary embolism	179.47	10.89	418	59862	108167	46517615
Arthralgia	174.45	10.89	130	60150	364473	46261309
Emotional distress	173.33	10.89	206	60074	30501	46595281
Completed suicide	173.27	10.89	3	60277	145917	46479865
Haematoma	172.02	10.89	209	60071	31663	46594119
Retroperitoneal haematoma	163.39	10.89	76	60204	2564	46623218
Unevaluable event	161.16	10.89	245	60035	45930	46579852
Labelled drug-drug interaction medication error	159.61	10.89	115	60165	8946	46616836
Vascular stent thrombosis	152.35	10.89	53	60227	818	46624964
Hereditary angioedema	145.47	10.89	90	60190	5426	46620356
Cardiogenic shock	132.78	10.89	133	60147	16251	46609531
Drug ineffective	128.73	10.89	448	59832	677390	45948392
Vascular pseudoaneurysm	128.61	10.89	53	60227	1327	46624455
Thrombosis	127.55	10.89	246	60034	55823	46569959
Extradural haematoma	123.69	10.89	52	60228	1371	46624411
Joint swelling	118.09	10.89	34	60246	166039	46459743
Abdominal wall haematoma	116.18	10.89	62	60218	2819	46622963
Drug intolerance	112.40	10.89	26	60254	147023	46478759
Fatigue	112.31	10.89	407	59873	608290	46017492
Exposure during pregnancy	107.83	10.89	346	59934	107866	46517916
Deep vein thrombosis	106.30	10.89	283	59997	79490	46546292
Haemoglobin decreased	105.47	10.89	386	59894	128563	46497219
Acute kidney injury	105.41	10.89	590	59690	235265	46390517
Product dose omission issue	105.12	10.89	43	60237	168477	46457305
Cerebral infarction	103.61	10.89	139	60141	23227	46602555
Cardiac arrest	102.10	10.89	302	59978	90097	46535685
Hypotension	101.40	10.89	578	59702	232011	46393771
Renal impairment	100.27	10.89	265	60015	74107	46551675
Coronary artery thrombosis	92.74	10.89	40	60240	1125	46624657
Compartment syndrome	91.99	10.89	47	60233	1952	46623830
Cardiac tamponade	86.48	10.89	60	60220	4394	46621388
Platelet count decreased	85.65	10.89	304	59976	99720	46526062
Malaise	85.64	10.89	188	60092	331044	46294738
Toxic epidermal necrolysis	84.56	10.89	123	60157	22155	46603627
Disseminated intravascular coagulation	84.17	10.89	113	60167	18892	46606890
Haemoperitoneum	82.44	10.89	47	60233	2435	46623347
Psoriasis	81.52	10.89	5	60275	78599	46547183
Arthropathy	80.53	10.89	8	60272	84692	46541090
Alopecia	79.96	10.89	56	60224	162358	46463424
Haemothorax	77.26	10.89	42	60238	1982	46623800
Peripheral ischaemia	76.06	10.89	56	60224	4503	46621279
Spinal epidural haematoma	75.94	10.89	31	60249	757	46625025
Premature baby	74.64	10.89	104	60176	18008	46607774
Nasopharyngitis	73.33	10.89	55	60225	153943	46471839
Embolism	71.21	10.89	65	60215	7073	46618709
Toxicity to various agents	69.14	10.89	104	60176	211662	46414120
Vena cava thrombosis	69.00	10.89	40	60240	2139	46623643
Respiratory failure	68.55	10.89	273	60007	94543	46531239
Haematoma muscle	68.47	10.89	27	60253	601	46625181
Pharyngeal haemorrhage	68.37	10.89	26	60254	523	46625259
Coagulation time shortened	67.84	10.89	19	60261	135	46625647
Muscle haemorrhage	67.67	10.89	46	60234	3258	46622524
Adrenal haemorrhage	67.02	10.89	23	60257	340	46625442
Diarrhoea	66.99	10.89	436	59844	559166	46066616
Gastrointestinal haemorrhage	66.93	10.89	236	60044	77137	46548645
Subarachnoid haemorrhage	66.53	10.89	77	60203	11076	46614706
Procedural haemorrhage	65.64	10.89	40	60240	2346	46623436
Subdural haematoma	64.91	10.89	82	60198	12915	46612867
Intentional overdose	64.81	10.89	5	60275	64939	46560843
Skin necrosis	64.53	10.89	67	60213	8537	46617245
Heparin-induced thrombocytopenia test positive	64.40	10.89	12	60268	4	46625778
Cardiac valve replacement complication	63.60	10.89	19	60261	174	46625608
Drug abuse	62.94	10.89	5	60275	63403	46562379
Coagulopathy	61.47	10.89	96	60184	18403	46607379
Abdominal discomfort	61.09	10.89	63	60217	151102	46474680
Injection site pain	61.08	10.89	31	60249	107121	46518661
Coagulation time prolonged	60.77	10.89	31	60249	1283	46624499
Puncture site haemorrhage	60.49	10.89	20	60260	262	46625520
Post procedural haemorrhage	59.64	10.89	60	60220	7366	46618416
Stress	58.90	10.89	173	60107	51378	46574404
Weight decreased	58.35	10.89	115	60165	210734	46415048
Caesarean section	57.75	10.89	88	60192	16515	46609267
Weight increased	57.40	10.89	77	60203	164396	46461386
Suicidal ideation	57.23	10.89	4	60276	56378	46569404
Dizziness	57.12	10.89	236	60044	340178	46285604
Blood pressure decreased	57.08	10.89	183	60097	56976	46568806
Acute myocardial infarction	56.07	10.89	126	60154	31798	46593984
Ventricular tachycardia	54.92	10.89	87	60193	16880	46608902
Gait disturbance	53.80	10.89	65	60215	145198	46480584
Shock	53.55	10.89	99	60181	21746	46604036
Sepsis	53.34	10.89	329	59951	135685	46490097
Foetal death	53.22	10.89	61	60219	8682	46617100
Treatment failure	52.95	10.89	27	60253	93060	46532722
Insomnia	52.84	10.89	82	60198	164842	46460940
Arthritis	52.79	10.89	17	60263	77299	46548483
Subchorionic haematoma	52.56	10.89	15	60265	115	46625667
Infective aneurysm	51.88	10.89	20	60260	418	46625364
Intra-abdominal haematoma	51.81	10.89	30	60250	1601	46624181
Intracardiac thrombus	51.76	10.89	34	60246	2274	46623508
Pericardial haemorrhage	50.52	10.89	29	60251	1522	46624260
Therapeutic product effect incomplete	50.24	10.89	19	60261	78134	46547648
Pain in extremity	50.10	10.89	169	60111	258511	46367271
Haematocrit decreased	49.34	10.89	127	60153	34930	46590852
Arterial thrombosis	48.85	10.89	27	60253	1317	46624465
Fall	48.10	10.89	240	60040	328857	46296925
Stevens-Johnson syndrome	47.87	10.89	98	60182	23199	46602583
Memory impairment	47.75	10.89	20	60260	77317	46548465
Aortic thrombosis	47.55	10.89	24	60256	971	46624811
Gangrene	47.32	10.89	43	60237	4652	46621130
Asthma	47.13	10.89	30	60250	91512	46534270
Intra-abdominal haemorrhage	46.67	10.89	32	60248	2298	46623484
Pemphigus	46.57	10.89	3	60277	45271	46580511
Post procedural complication	45.96	10.89	77	60203	15652	46610130
Splenic rupture	45.94	10.89	25	60255	1182	46624600
Brain herniation	45.69	10.89	35	60245	2988	46622794
Pulmonary alveolar haemorrhage	45.68	10.89	40	60240	4122	46621660
Low birth weight baby	45.66	10.89	45	60235	5389	46620393
Electrocardiogram ST segment elevation	45.63	10.89	38	60242	3657	46622125
Suicide attempt	45.62	10.89	8	60272	55028	46570754
Rash	44.98	10.89	273	60007	356239	46269543
Peripheral swelling	44.76	10.89	85	60195	157986	46467796
Choroidal infarction	44.59	10.89	12	60268	72	46625710
Catheter site haemorrhage	44.57	10.89	33	60247	2676	46623106
Feeling abnormal	44.18	10.89	58	60222	125002	46500780
Musculoskeletal stiffness	44.10	10.89	37	60243	97956	46527826
Aplastic anaemia	43.70	10.89	50	60230	7103	46618679
Thrombotic microangiopathy	42.42	10.89	53	60227	8253	46617529
Haemodynamic instability	42.21	10.89	51	60229	7674	46618108
Product use in unapproved indication	41.64	10.89	228	60052	90045	46535737
Paraplegia	41.28	10.89	30	60250	2364	46623418
Venous thrombosis	41.06	10.89	40	60240	4722	46621060
Myalgia	40.56	10.89	60	60220	123028	46502754
Acute motor-sensory axonal neuropathy	40.49	10.89	16	60264	358	46625424
Foetal exposure during pregnancy	39.82	10.89	108	60172	30639	46595143
Eye excision	39.19	10.89	10	60270	47	46625735
Peripheral artery thrombosis	38.99	10.89	26	60254	1783	46623999
Injection site erythema	38.85	10.89	24	60256	74403	46551379
Intentional product misuse	38.74	10.89	7	60273	47121	46578661
Pulmonary infarction	38.35	10.89	30	60250	2641	46623141
Petechiae	38.32	10.89	63	60217	12607	46613175
Procedural complication	38.07	10.89	39	60241	4891	46620891
Hypoxia	38.03	10.89	150	60130	51688	46574094
Intraventricular haemorrhage	37.77	10.89	26	60254	1879	46623903
Pulmonary haemorrhage	37.28	10.89	44	60236	6461	46619321
Muscle spasms	36.81	10.89	64	60216	123049	46502733
Retinal pigment epitheliopathy	36.43	10.89	13	60267	217	46625565
Ischaemic stroke	36.33	10.89	72	60208	16650	46609132
Peritonitis bacterial	36.11	10.89	50	60230	8603	46617179
Ventricular fibrillation	35.91	10.89	58	60222	11438	46614344
Oliguria	35.64	10.89	50	60230	8709	46617073
Systemic lupus erythematosus	34.04	10.89	21	60259	65159	46560623
Hemiparesis	33.89	10.89	78	60202	19991	46605791
International normalised ratio increased	33.86	10.89	135	60145	46748	46579034
Spinal cord compression	33.76	10.89	32	60248	3652	46622130
Leg amputation	33.65	10.89	25	60255	2038	46623744
Rectosigmoid cancer	33.14	10.89	11	60269	146	46625636
Fluid overload	32.75	10.89	93	60187	27092	46598690
Splenic infarction	32.46	10.89	22	60258	1550	46624232
Injection site pruritus	32.46	10.89	6	60274	39737	46586045
Septic shock	32.11	10.89	154	60126	57739	46568043
Loss of personal independence in daily activities	31.89	10.89	17	60263	57166	46568616
Atrial thrombosis	31.72	10.89	21	60259	1423	46624359
Eosinophilia	31.69	10.89	74	60206	19143	46606639
Platelet aggregation inhibition	31.51	10.89	10	60270	114	46625668
Gastrooesophageal reflux disease	31.14	10.89	30	60250	74314	46551468
Coronary artery dissection	31.10	10.89	16	60264	674	46625108
Extraocular muscle disorder	31.04	10.89	10	60270	120	46625662
Injection site swelling	31.04	10.89	7	60273	40320	46585462
Protein C decreased	30.95	10.89	8	60272	40	46625742
Pulseless electrical activity	30.79	10.89	42	60238	7125	46618657
Intracranial haematoma	30.67	10.89	13	60267	350	46625432
Fear of death	30.62	10.89	18	60262	988	46624794
Oesophageal intramural haematoma	30.17	10.89	9	60271	82	46625700
Procedural hypotension	30.15	10.89	19	60261	1183	46624599
Injection site reaction	30.14	10.89	12	60268	47837	46577945
Catheter site haematoma	29.83	10.89	10	60270	137	46625645
Embolic cerebral infarction	29.72	10.89	14	60266	486	46625296
HELLP syndrome	29.33	10.89	17	60263	909	46624873
Heparin-induced thrombocytopenia test	29.29	10.89	6	60274	7	46625775
Protein S decreased	29.18	10.89	8	60272	52	46625730
Tachypnoea	29.04	10.89	60	60220	14291	46611491
Ischaemia	28.86	10.89	32	60248	4392	46621390
Hemiplegia	28.82	10.89	40	60240	6898	46618884
Blood cholesterol increased	28.76	10.89	8	60272	40005	46585777
Cerebral venous thrombosis	28.63	10.89	23	60257	2104	46623678
Osteoarthritis	28.42	10.89	23	60257	62002	46563780
Hand amputation	28.27	10.89	5	60275	0	46625782
Haemorrhagic transformation stroke	28.11	10.89	18	60262	1152	46624630
Prothrombin time prolonged	28.06	10.89	47	60233	9549	46616233
Influenza	27.98	10.89	45	60235	89225	46536557
Wrong technique in product usage process	27.78	10.89	18	60262	54404	46571378
Toxoplasmosis	27.58	10.89	19	60261	1375	46624407
Hypercoagulation	27.51	10.89	22	60258	2000	46623782
Acute generalised exanthematous pustulosis	27.42	10.89	46	60234	9359	46616423
Device related infection	27.34	10.89	74	60206	20967	46604815
Headache	27.34	10.89	444	59836	477908	46147874
Renal infarct	27.33	10.89	18	60262	1209	46624573
Spinal subdural haematoma	27.14	10.89	9	60271	119	46625663
Cerebral haematoma	26.85	10.89	27	60253	3312	46622470
Product measured potency issue	26.80	10.89	9	60271	124	46625658
Haemodialysis	26.76	10.89	45	60235	9172	46616610
Renal vein thrombosis	26.34	10.89	11	60269	285	46625497
Anxiety	26.19	10.89	354	59926	181603	46444179
Cerebellar haemorrhage	26.03	10.89	18	60262	1311	46624471
Jugular vein thrombosis	26.02	10.89	24	60256	2646	46623136
Pulse absent	25.91	10.89	32	60248	4924	46620858
Mobility decreased	25.90	10.89	24	60256	60570	46565212
Post procedural haematoma	25.76	10.89	18	60262	1333	46624449
Product contamination	25.62	10.89	13	60267	532	46625250
Asthenia	25.37	10.89	268	60012	310807	46314975
Haemoptysis	25.36	10.89	83	60197	26106	46599676
Anti factor Xa activity decreased	25.33	10.89	5	60275	4	46625778
Haemolysis	25.27	10.89	35	60245	6024	46619758
Device expulsion	25.15	10.89	3	60277	27539	46598243
Pulmonary artery thrombosis	24.97	10.89	14	60266	702	46625080
Lipoedema	24.75	10.89	9	60271	159	46625623
Acute respiratory distress syndrome	24.48	10.89	73	60207	21849	46603933
Drug chemical incompatibility	24.38	10.89	7	60273	55	46625727
Vasodilatation	24.34	10.89	22	60258	2363	46623419
Peritonitis	24.11	10.89	70	60210	20644	46605138
Peritoneal dialysis complication	23.93	10.89	23	60257	2671	46623111
Graft thrombosis	23.85	10.89	9	60271	177	46625605
Pituitary apoplexy	23.77	10.89	8	60272	111	46625671
Encephalopathy	23.67	10.89	96	60184	33493	46592289
Transcription medication error	23.67	10.89	9	60271	181	46625601
Coronary artery perforation	23.55	10.89	6	60274	28	46625754
Cerebrovascular accident	23.43	10.89	216	60064	100823	46524959
Subcapsular renal haematoma	23.43	10.89	10	60270	274	46625508
Tremor	23.41	10.89	74	60206	115565	46510217
Breast cancer	23.30	10.89	15	60265	45503	46580279
Tonsillar haemorrhage	23.18	10.89	9	60271	192	46625590
Somnolence	22.89	10.89	114	60166	156407	46469375
Cerebellar embolism	22.61	10.89	4	60276	0	46625782
Decreased appetite	22.56	10.89	152	60128	193684	46432098
Haematuria	22.41	10.89	81	60199	26777	46599005
Blood fibrinogen decreased	22.39	10.89	13	60267	697	46625085
Choroidal effusion	22.31	10.89	11	60269	423	46625359
Lower respiratory tract infection	22.18	10.89	23	60257	55066	46570716
Arterial intramural haematoma	22.16	10.89	5	60275	12	46625770
Wound	22.06	10.89	14	60266	42788	46582994
Dry mouth	22.04	10.89	23	60257	54903	46570879
Coagulation time abnormal	22.04	10.89	7	60273	80	46625702
Stillbirth	22	10.89	34	60246	6457	46619325
Arterial haemorrhage	21.91	10.89	18	60262	1700	46624082
Mediastinal haemorrhage	21.88	10.89	5	60275	13	46625769
Cataract	21.87	10.89	16	60264	45399	46580383
Foetal growth restriction	21.70	10.89	34	60246	6533	46619249
Abdominal compartment syndrome	21.64	10.89	12	60268	589	46625193
Hydrocephalus	21.59	10.89	29	60251	4848	46620934
Hepatic infarction	21.58	10.89	12	60268	592	46625190
Incorrect drug administration rate	21.56	10.89	19	60261	1974	46623808
Cerebral amyloid angiopathy	21.41	10.89	8	60272	153	46625629
Spinal cord disorder	21.37	10.89	15	60265	1119	46624663
Fibrin D dimer increased	21.33	10.89	26	60254	3947	46621835
Stress cardiomyopathy	21.28	10.89	37	60243	7747	46618035
Inflammation	21.23	10.89	19	60261	48762	46577020
Ischaemic hepatitis	21.08	10.89	19	60261	2034	46623748
Contraindicated product administered	20.89	10.89	45	60235	79902	46545880
Haemorrhage subcutaneous	20.67	10.89	22	60258	2884	46622898
Cerebral artery thrombosis	20.66	10.89	10	60270	369	46625413
Arm amputation	20.66	10.89	5	60275	18	46625764
Premature rupture of membranes	20.66	10.89	27	60253	4396	46621386
Cerebral artery embolism	20.52	10.89	13	60267	817	46624965
Cerebral vasoconstriction	20.25	10.89	14	60266	1019	46624763
Blood pressure fluctuation	20.24	10.89	7	60273	30441	46595341
Incision site haemorrhage	20.24	10.89	11	60269	519	46625263
Haemorrhagic stroke	20.06	10.89	30	60250	5536	46620246
Hypersensitivity	20.02	10.89	113	60167	150208	46475574
Cerebral reperfusion injury	19.85	10.89	4	60276	4	46625778
Haemorrhagic infarction	19.81	10.89	9	60271	287	46625495
Anti-platelet antibody positive	19.79	10.89	6	60274	58	46625724
Paratonia	19.68	10.89	5	60275	23	46625759
Product administration error	19.62	10.89	63	60217	19618	46606164
Back pain	19.61	10.89	175	60105	209864	46415918
Hepatic haematoma	19.47	10.89	10	60270	420	46625362
Atrial fibrillation	19.45	10.89	212	60068	103378	46522404
Psychotic disorder	19.39	10.89	3	60277	22618	46603164
Peritoneal haematoma	19.35	10.89	6	60274	63	46625719
Spinal cord oedema	19.28	10.89	7	60273	123	46625659
Vascular pseudoaneurysm ruptured	19.18	10.89	6	60274	65	46625717
Postpartum haemorrhage	19.18	10.89	17	60263	1780	46624002
Rash maculo-papular	19.12	10.89	79	60201	27795	46597987
Suspected transmission of an infectious agent via product	19.02	10.89	8	60272	211	46625571
Fungal sepsis	18.93	10.89	14	60266	1133	46624649
Balance disorder	18.86	10.89	34	60246	64487	46561295
Visual impairment	18.73	10.89	36	60244	66653	46559129
Vascular access site haemorrhage	18.58	10.89	4	60276	7	46625775
Device occlusion	18.57	10.89	30	60250	5915	46619867
Mucosal erosion	18.57	10.89	15	60265	1383	46624399
Blood creatinine increased	18.56	10.89	165	60115	76238	46549544
Respiratory distress	18.50	10.89	86	60194	31830	46593952
Dry eye	18.46	10.89	8	60272	30314	46595468
Depressed mood	18.44	10.89	10	60270	33309	46592473
Pulmonary oedema	18.38	10.89	121	60159	50984	46574798
Vasospasm	18.37	10.89	11	60269	625	46625157
Dyspepsia	18.34	10.89	38	60242	68434	46557348
Activated partial thromboplastin time shortened	18.16	10.89	9	60271	350	46625432
Unresponsive to stimuli	18.14	10.89	86	60194	32088	46593694
Arterial stenosis	18.13	10.89	11	60269	640	46625142
Cardiac failure	18.07	10.89	170	60110	79778	46546004
Infection	18.02	10.89	100	60180	133492	46492290
Tachycardia	17.84	10.89	202	60078	99420	46526362
Kidney rupture	17.79	10.89	5	60275	36	46625746
Calciphylaxis	17.69	10.89	19	60261	2516	46623266
Iris neovascularisation	17.67	10.89	5	60275	37	46625745
Haemodialysis complication	17.53	10.89	8	60272	258	46625524
Blood albumin decreased	17.51	10.89	48	60232	13697	46612085
Anaemia	17.47	10.89	443	59837	255336	46370446
Osteoporosis	17.45	10.89	16	60264	40592	46585190
Ventricle rupture	17.34	10.89	4	60276	11	46625771
Myelomalacia	17.33	10.89	5	60275	40	46625742
Similar reaction on previous exposure to drug	17.23	10.89	5	60275	41	46625741
Subdural haemorrhage	17.19	10.89	20	60260	2892	46622890
Spinal cord haemorrhage	17.18	10.89	7	60273	170	46625612
Ureteric haemorrhage	16.96	10.89	3	60277	0	46625782
Rhinorrhoea	16.93	10.89	22	60258	47643	46578139
Injection site plaque	16.81	10.89	5	60275	45	46625737
Phaeochromocytoma crisis	16.78	10.89	7	60273	181	46625601
Ecchymosis	16.65	10.89	40	60240	10536	46615246
Cardiac death	16.62	10.89	10	60270	573	46625209
Ejection fraction decreased	16.61	10.89	56	60224	17881	46607901
Neurological symptom	16.55	10.89	25	60255	4654	46621128
Foetal exposure timing unspecified	16.36	10.89	7	60273	193	46625589
Adverse drug reaction	16.25	10.89	20	60260	44342	46581440
Sleep disorder	16.21	10.89	22	60258	46773	46579009
Immune thrombocytopenia	16.14	10.89	34	60246	8207	46617575
Organ failure	16.10	10.89	18	60262	2492	46623290
Fat embolism	16.06	10.89	7	60273	202	46625580
Platelet aggregation test	16.00	10.89	4	60276	17	46625765
Antiphospholipid syndrome	15.93	10.89	15	60265	1697	46624085
Swelling	15.83	10.89	95	60185	124416	46501366
Blood culture positive	15.81	10.89	24	60256	4488	46621294
Threatened labour	15.80	10.89	11	60269	810	46624972
Red blood cell sedimentation rate increased	15.68	10.89	5	60275	22884	46602898
Retinoblastoma	15.49	10.89	6	60274	127	46625655
Hepatic enzyme increased	15.41	10.89	54	60226	81733	46544049
Dysphagia	15.28	10.89	50	60230	77262	46548520
Pleural effusion	15.22	10.89	169	60111	82783	46542999
Cough	15.07	10.89	208	60072	230041	46395741
Premature labour	14.94	10.89	40	60240	11259	46614523
Mouth ulceration	14.93	10.89	8	60272	26824	46598958
Ill-defined disorder	14.92	10.89	8	60272	26819	46598963
Bradycardia foetal	14.90	10.89	8	60272	368	46625414
Aneurysm recanalisation	14.89	10.89	3	60277	3	46625779
Medical device site thrombosis	14.89	10.89	3	60277	3	46625779
Pelvic venous thrombosis	14.88	10.89	14	60266	1583	46624199
Capillary fragility test	14.86	10.89	4	60276	24	46625758
Thrombolysis	14.82	10.89	5	60275	70	46625712
Necrosis	14.77	10.89	24	60256	4756	46621026
Vision blurred	14.77	10.89	53	60227	79655	46546127
Nervous system disorder	14.63	10.89	50	60230	16079	46609703
Dialysis	14.59	10.89	37	60243	10079	46615703
Platelet transfusion	14.57	10.89	10	60270	719	46625063
Carotid artery thrombosis	14.56	10.89	10	60270	720	46625062
Venous occlusion	14.52	10.89	10	60270	723	46625059
Acute respiratory failure	14.38	10.89	75	60205	29063	46596719
Multiple sclerosis	14.37	10.89	7	60273	24784	46600998
Blood creatine increased	14.12	10.89	23	60257	4567	46621215
Organic brain syndrome	14.10	10.89	6	60274	163	46625619
Live birth	14.09	10.89	37	60243	10293	46615489
Intestinal ischaemia	14.07	10.89	29	60251	6896	46618886
Cerebrovascular disorder	14.04	10.89	18	60262	2876	46622906
Cyanosis	14.04	10.89	49	60231	15922	46609860
Artery dissection	13.98	10.89	5	60275	84	46625698
Uterine haematoma	13.98	10.89	4	60276	31	46625751
Renal artery thrombosis	13.93	10.89	5	60275	85	46625697
Infarction	13.91	10.89	16	60264	2285	46623497
Seizure like phenomena	13.91	10.89	11	60269	984	46624798
Fibromyalgia	13.82	10.89	16	60264	36447	46589335
Crying	13.81	10.89	5	60275	21136	46604646
Hepatic failure	13.81	10.89	82	60198	33334	46592448
Haemorrhagic cerebral infarction	13.77	10.89	9	60271	597	46625185
Antithrombin III decreased	13.76	10.89	7	60273	288	46625494
Accidental exposure to product	13.75	10.89	5	60275	21076	46604706
Renal haematoma	13.71	10.89	6	60274	175	46625607
Renal haemorrhage	13.67	10.89	10	60270	796	46624986
Bleeding time prolonged	13.63	10.89	9	60271	607	46625175
Herpes simplex hepatitis	13.60	10.89	7	60273	295	46625487
Febrile neutropenia	13.55	10.89	184	60096	94443	46531339
Cardiopulmonary failure	13.54	10.89	20	60260	3649	46622133
Nephrogenic systemic fibrosis	13.46	10.89	23	60257	4749	46621033
Cholestatic liver injury	13.43	10.89	15	60265	2075	46623707
Multiple sclerosis relapse	13.42	10.89	21	60259	42104	46583678
Therapy cessation	13.33	10.89	9	60271	26620	46599162
Recurrence of neuromuscular blockade	13.27	10.89	5	60275	98	46625684
Cardiac ventricular thrombosis	13.22	10.89	8	60272	463	46625319
Femur fracture	13.21	10.89	17	60263	36980	46588802
Vessel puncture site haemorrhage	13.17	10.89	5	60275	100	46625682
Subclavian vein thrombosis	13.17	10.89	14	60266	1832	46623950
Osteonecrosis of jaw	13.14	10.89	15	60265	34387	46591395
Injection site bruising	13.12	10.89	16	60264	35620	46590162
Foetal warfarin syndrome	13.07	10.89	3	60277	8	46625774
Circulatory collapse	13.07	10.89	59	60221	21565	46604217
International normalised ratio decreased	13.03	10.89	22	60258	4498	46621284
Hemianopia homonymous	12.98	10.89	9	60271	658	46625124
Aneurysm ruptured	12.96	10.89	8	60272	480	46625302
Irritability	12.93	10.89	11	60269	28935	46596847
Electrocardiogram T wave alternans	12.90	10.89	4	60276	42	46625740
Tooth disorder	12.89	10.89	7	60273	23296	46602486
Anaphylactoid reaction	12.84	10.89	19	60261	3472	46622310
Periorbital cellulitis	12.78	10.89	8	60272	492	46625290
Patent ductus arteriosus	12.77	10.89	20	60260	3842	46621940
Enterococcal infection	12.74	10.89	28	60252	6959	46618823
Eosinophil cationic protein increased	12.73	10.89	4	60276	44	46625738
Arterial rupture	12.73	10.89	7	60273	338	46625444
Bronchial haemorrhage	12.73	10.89	7	60273	338	46625444
Paraesthesia	12.71	10.89	94	60186	117343	46508439
Eschar	12.71	10.89	8	60272	497	46625285
Vaginal haemorrhage	12.70	10.89	66	60214	25538	46600244
Vascular parkinsonism	12.69	10.89	5	60275	111	46625671
Umbilical cord vascular disorder	12.69	10.89	5	60275	111	46625671
Paralysis	12.69	10.89	32	60248	8689	46617093
Thoracic haemorrhage	12.65	10.89	4	60276	45	46625737
Paraparesis	12.60	10.89	14	60266	1925	46623857
Adrenomegaly	12.57	10.89	3	60277	10	46625772
Acne	12.53	10.89	5	60275	19914	46605868
Hospitalisation	12.52	10.89	41	60239	63344	46562438
Confusional state	12.50	10.89	139	60141	159753	46466029
Joint stiffness	12.48	10.89	10	60270	27098	46598684
Palpitations	12.46	10.89	72	60208	95187	46530595
Irritable bowel syndrome	12.44	10.89	3	60277	16512	46609270
Reperfusion injury	12.42	10.89	4	60276	48	46625734
Cardio-respiratory arrest	12.40	10.89	125	60155	59744	46566038
Pseudomonas infection	12.36	10.89	34	60246	9724	46616058
Abdominal pain upper	12.30	10.89	124	60156	145181	46480601
Reperfusion arrhythmia	12.27	10.89	4	60276	50	46625732
Protein S deficiency	12.27	10.89	4	60276	50	46625732
Colorectal cancer	12.24	10.89	10	60270	937	46624845
Gastrointestinal disorder	12.14	10.89	38	60242	59538	46566244
Dysgeusia	12.14	10.89	21	60259	40470	46585312
Pericarditis	12.09	10.89	8	60272	23919	46601863
Leukocytosis	12.08	10.89	61	60219	23337	46602445
Normal newborn	12.04	10.89	25	60255	5976	46619806
Peripheral embolism	11.92	10.89	11	60269	1213	46624569
Vascular malformation	11.92	10.89	5	60275	131	46625651
Device related thrombosis	11.90	10.89	11	60269	1216	46624566
Mental status changes	11.82	10.89	87	60193	38001	46587781
Klebsiella test positive	11.79	10.89	10	60270	987	46624795
Hot flush	11.78	10.89	24	60256	43493	46582289
Gallbladder disorder	11.67	10.89	4	60276	17494	46608288
Plantar erythema	11.55	10.89	6	60274	258	46625524
Therapeutic product effect increased	11.51	10.89	10	60270	1020	46624762
Foetal placental thrombosis	11.48	10.89	4	60276	62	46625720
Intracranial pressure increased	11.46	10.89	20	60260	4200	46621582
Vitreous haemorrhage	11.45	10.89	13	60267	1831	46623951
Pericardial effusion	11.42	10.89	64	60216	25479	46600303
Gestational hypertension	11.40	10.89	14	60266	2141	46623641
Gaze palsy	11.37	10.89	11	60269	1287	46624495
Musculoskeletal disorder	11.37	10.89	3	60277	15542	46610240
Budd-Chiari syndrome	11.36	10.89	4	60276	64	46625718
Blood phosphorus increased	11.33	10.89	16	60264	2803	46622979
Graft haemorrhage	11.29	10.89	3	60277	17	46625765
White blood cell count decreased	11.14	10.89	92	60188	112139	46513643
Cholestasis	11.12	10.89	66	60214	26827	46598955
Breast necrosis	11.11	10.89	5	60275	156	46625626
Hypovolaemia	11.11	10.89	33	60247	9855	46615927
Urticaria	11.09	10.89	98	60182	117794	46507988
Tracheal haemorrhage	11.05	10.89	5	60275	158	46625624
Mouth haemorrhage	11.04	10.89	25	60255	6337	46619445
Abortion early	11.01	10.89	3	60277	19	46625763
Extremity necrosis	10.98	10.89	12	60268	1621	46624161
Haemoglobin abnormal	10.98	10.89	20	60260	4343	46621439
Drug dependence	10.97	10.89	6	60274	19895	46605887
Ruptured cerebral aneurysm	10.96	10.89	7	60273	446	46625336
Vascular graft occlusion	10.93	10.89	5	60275	162	46625620
Wheezing	10.91	10.89	34	60246	53352	46572430
Apgar score low	10.89	10.89	8	60272	641	46625141

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heparin-induced thrombocytopenia	3749.43	11.02	1063	64110	4320	29882985
Fear	610.80	11.02	347	64826	10478	29876827
Renal injury	533.22	11.02	327	64846	11402	29875903
Injury	528.23	11.02	412	64761	21319	29865986
Thrombocytopenia	527.98	11.02	1013	64160	136031	29751274
Anhedonia	457.93	11.02	263	64910	8106	29879199
Emotional distress	418.37	11.02	315	64858	15450	29871855
Unevaluable event	366.75	11.02	397	64776	31388	29855917
Stress	301.15	11.02	290	64883	19945	29867360
Haemorrhage	281.25	11.02	419	64754	45660	29841645
Activated partial thromboplastin time prolonged	280.70	11.02	188	64985	7640	29879665
Multiple organ dysfunction syndrome	279.74	11.02	498	64675	62989	29824316
Renal failure	254.93	11.02	735	64438	128231	29759074
Vascular stent thrombosis	236.14	11.02	111	65062	2232	29885073
Post procedural haemorrhage	232.16	11.02	168	65005	7742	29879563
Haematoma	231.57	11.02	273	64900	23680	29863625
Thrombosis in device	226.05	11.02	123	65050	3403	29883902
Fatigue	217.56	11.02	227	64946	320446	29566859
Haemorrhage intracranial	198.70	11.02	202	64971	14830	29872475
Retroperitoneal haematoma	175.40	11.02	93	65080	2439	29884866
Cerebral haemorrhage	172.53	11.02	279	64894	32608	29854697
Labelled drug-drug interaction medication error	164.27	11.02	155	65018	10383	29876922
Cardiogenic shock	159.34	11.02	190	64983	16671	29870634
Cardiac tamponade	153.32	11.02	106	65067	4538	29882767
Retroperitoneal haemorrhage	150.28	11.02	86	65087	2629	29884676
Thrombosis	140.12	11.02	294	64879	41937	29845368
Drug abuse	139.97	11.02	10	65163	82062	29805243
Shock haemorrhagic	138.51	11.02	137	65036	9728	29877577
Pulmonary embolism	134.91	11.02	425	64748	77710	29809595
Coagulation time shortened	130.28	11.02	38	65135	173	29887132
Toxicity to various agents	126.02	11.02	120	65053	177063	29710242
Renal impairment	118.87	11.02	428	64745	83756	29803549
Weight decreased	117.23	11.02	94	65079	150827	29736478
Anxiety	114.47	11.02	442	64731	89429	29797876
Diarrhoea	112.90	11.02	363	64810	333740	29553565
Arthralgia	111.30	11.02	80	65093	135711	29751594
Heparin-induced thrombocytopenia test positive	103.76	11.02	25	65148	42	29887263
Deep vein thrombosis	103.38	11.02	328	64845	60173	29827132
Arterial thrombosis	101.24	11.02	53	65120	1353	29885952
Product dose omission issue	100.26	11.02	37	65136	91594	29795711
Catheter site haemorrhage	99.78	11.02	61	65112	2111	29885194
Coagulation time prolonged	98.92	11.02	50	65123	1184	29886121
Ventricular fibrillation	95.61	11.02	140	65033	14998	29872307
Dizziness	92.90	11.02	177	64996	194732	29692573
Intraventricular haemorrhage	90.37	11.02	65	65108	2965	29884340
Decreased appetite	88.54	11.02	118	65055	149792	29737513
Asthenia	86.59	11.02	224	64949	221066	29666239
Heparin-induced thrombocytopenia test	85.85	11.02	25	65148	113	29887192
Haemoglobin decreased	83.82	11.02	478	64695	113620	29773685
Hypotension	82.64	11.02	730	64443	199835	29687470
Procedural complication	81.51	11.02	72	65101	4425	29882880
Heparin resistance	80.97	11.02	18	65155	16	29887289
Post procedural complication	77.77	11.02	111	65062	11615	29875690
Pulmonary haemorrhage	77.69	11.02	99	65074	9293	29878012
Coronary artery thrombosis	77.62	11.02	52	65121	2112	29885193
Subarachnoid haemorrhage	76.76	11.02	101	65072	9785	29877520
Malaise	75.75	11.02	156	65017	166806	29720499
Coagulation time abnormal	75.17	11.02	24	65149	156	29887149
Insomnia	75.11	11.02	56	65117	93280	29794025
Ventricular tachycardia	74.35	11.02	162	65011	23700	29863605
Brain herniation	74.10	11.02	63	65110	3677	29883628
Psoriasis	72.96	11.02	5	65168	42501	29844804
Venous thrombosis	71.40	11.02	58	65115	3176	29884129
Antibody test positive	71.36	11.02	33	65140	638	29886667
Joint swelling	71.35	11.02	9	65164	46937	29840368
Muscle haemorrhage	70.56	11.02	61	65112	3642	29883663
Fall	70.40	11.02	185	64988	181687	29705618
Pulmonary alveolar haemorrhage	68.57	11.02	78	65095	6503	29880802
Intentional overdose	68.05	11.02	6	65167	41475	29845830
Disseminated intravascular coagulation	67.35	11.02	149	65024	22022	29865283
Compartment syndrome	65.89	11.02	50	65123	2477	29884828
Cardiac arrest	65.55	11.02	385	64788	92465	29794840
Septic shock	63.84	11.02	291	64882	63316	29823989
Suicidal ideation	62.71	11.02	4	65169	36110	29851195
Pulseless electrical activity	62.22	11.02	72	65101	6115	29881190
Pericardial haemorrhage	61.62	11.02	51	65122	2867	29884438
Coagulation time	61.59	11.02	12	65161	0	29887305
Suicide attempt	61.04	11.02	5	65168	36692	29850613
Weight increased	60.19	11.02	45	65128	74868	29812437
Haemodynamic instability	59.33	11.02	80	65093	7935	29879370
Product contamination	57.06	11.02	28	65145	621	29886684
Intra-abdominal haemorrhage	55.71	11.02	42	65131	2060	29885245
Dehydration	55.50	11.02	116	65057	123423	29763882
Myalgia	54.31	11.02	52	65121	76615	29810690
Pharyngeal haemorrhage	52.23	11.02	27	65146	671	29886634
Intracardiac thrombus	52.14	11.02	43	65130	2405	29884900
Muscle spasms	52.02	11.02	39	65134	64799	29822506
Procedural haemorrhage	51.76	11.02	42	65131	2296	29885009
Myocardial rupture	50.62	11.02	18	65155	169	29887136
Peripheral ischaemia	50.19	11.02	60	65113	5274	29882031
Low birth weight baby	50.18	11.02	64	65109	6012	29881293
Nasopharyngitis	49.03	11.02	34	65139	58815	29828490
Product measured potency issue	48.14	11.02	15	65158	89	29887216
Fear of death	47.94	11.02	25	65148	633	29886672
Nausea	47.37	11.02	416	64757	296541	29590764
Vascular pseudoaneurysm	46.55	11.02	37	65136	1963	29885342
Extraocular muscle disorder	46.08	11.02	17	65156	179	29887126
Gait disturbance	46.01	11.02	57	65116	74720	29812585
Somnolence	45.89	11.02	88	65085	96675	29790630
Product administration error	45.22	11.02	98	65075	14279	29873026
Coagulopathy	45.02	11.02	114	65059	18373	29868932
Peripheral swelling	44.93	11.02	40	65133	61034	29826271
Respiratory failure	44.82	11.02	373	64800	100269	29787036
Pain	44.47	11.02	572	64601	172069	29715236
Coagulation test abnormal	44.18	11.02	21	65152	433	29886872
Haematuria	44.14	11.02	204	64969	44630	29842675
Neuropathy peripheral	44.12	11.02	53	65120	70422	29816883
Anti-platelet antibody positive	43.81	11.02	18	65155	258	29887047
Cardiac ventricular thrombosis	43.45	11.02	25	65148	772	29886533
Unresponsive to stimuli	43.05	11.02	141	65032	26278	29861027
Retinal pigment epitheliopathy	43.01	11.02	17	65156	219	29887086
Adrenal haemorrhage	42.59	11.02	16	65157	178	29887127
Skin necrosis	42.57	11.02	52	65121	4675	29882630
Drug intolerance	42.13	11.02	23	65150	45268	29842037
Gastrointestinal haemorrhage	41.93	11.02	318	64855	83128	29804177
Aggression	41.88	11.02	14	65159	36893	29850412
Electrocardiogram ST segment elevation	41.85	11.02	50	65123	4392	29882913
Post procedural haematoma	41.20	11.02	31	65142	1516	29885789
Acute respiratory distress syndrome	40.72	11.02	128	65045	23344	29863961
Puncture site haemorrhage	40.09	11.02	18	65155	324	29886981
Musculoskeletal stiffness	40.04	11.02	14	65159	35867	29851438
Arterial haemorrhage	39.15	11.02	23	65150	739	29886566
Sepsis	38.93	11.02	488	64685	145907	29741398
Aortic thrombosis	38.72	11.02	22	65151	663	29886642
Rash	38.50	11.02	252	64921	191637	29695668
Feeling abnormal	38.46	11.02	40	65133	56716	29830589
Brain oedema	38.41	11.02	84	65089	12314	29874991
Cardiac procedure complication	38.10	11.02	16	65157	243	29887062
Atrial thrombosis	37.91	11.02	32	65141	1849	29885456
Coronary artery perforation	37.72	11.02	11	65162	50	29887255
Procedural hypotension	37.65	11.02	25	65148	1000	29886305
Memory impairment	37.40	11.02	17	65156	37157	29850148
Peripheral artery thrombosis	37.03	11.02	34	65139	2198	29885107
Haemothorax	36.86	11.02	42	65131	3507	29883798
Acute kidney injury	36.80	11.02	816	64357	273026	29614279
Dyspnoea	36.74	11.02	508	64665	332787	29554518
Balance disorder	36.23	11.02	17	65156	36476	29850829
Intentional product misuse	36.23	11.02	15	65158	34652	29852653
Asthma	35.69	11.02	17	65156	36157	29851148
Graft thrombosis	35.64	11.02	16	65157	288	29887017
Intestinal ischaemia	35.43	11.02	58	65115	6839	29880466
Appendicolith	35.18	11.02	23	65150	896	29886409
Influenza	34.93	11.02	26	65147	43372	29843933
Cough	34.07	11.02	149	65024	125493	29761812
Gangrene	34.07	11.02	46	65127	4568	29882737
Overdose	33.94	11.02	84	65089	84253	29803052
Cerebral infarction	33.73	11.02	130	65043	26243	29861062
Catheter site haematoma	33.64	11.02	13	65160	157	29887148
Injection site pain	33.53	11.02	12	65161	30298	29857007
Shock	32.85	11.02	117	65056	22742	29864563
Acute myocardial infarction	32.58	11.02	212	64961	52727	29834578
Torsade de pointes	32.36	11.02	57	65116	7133	29880172
Death	32.12	11.02	566	64607	356717	29530588
Headache	31.89	11.02	249	64924	182057	29705248
Hallucination	31.66	11.02	36	65137	49023	29838282
Haemorrhagic transformation stroke	31.48	11.02	24	65149	1197	29886108
Activated partial thromboplastin time shortened	31.08	11.02	16	65157	394	29886911
Alopecia	31.04	11.02	3	65170	19272	29868033
Hereditary angioedema	30.92	11.02	20	65153	765	29886540
Haemorrhagic cerebral infarction	30.90	11.02	20	65153	766	29886539
Embolism	30.81	11.02	55	65118	6954	29880351
Antiphospholipid syndrome	30.65	11.02	16	65157	406	29886899
Incision site pain	30.31	11.02	29	65144	1975	29885330
Pain in extremity	30.31	11.02	130	65043	110091	29777214
Gastric haemorrhage	30.31	11.02	65	65108	9402	29877903
Hospitalisation	30.29	11.02	31	65142	44288	29843017
Suspected product quality issue	29.85	11.02	12	65161	162	29887143
Irritability	29.38	11.02	7	65166	23043	29864262
Blood pressure decreased	29.26	11.02	189	64984	46886	29840419
Abdominal discomfort	29.16	11.02	38	65135	48753	29838552
Haemorrhagic infarction	29.04	11.02	15	65158	372	29886933
Vascular stent occlusion	28.84	11.02	11	65162	128	29887177
Kounis syndrome	28.76	11.02	26	65147	1647	29885658
Pulmonary haematoma	28.39	11.02	9	65164	57	29887248
Platelet count decreased	28.27	11.02	354	64819	105775	29781530
Herpes zoster	28.14	11.02	15	65158	29928	29857377
Drug dependence	28.08	11.02	6	65167	21289	29866016
Cerebral reperfusion injury	27.74	11.02	6	65167	4	29887301
Vena cava thrombosis	27.73	11.02	21	65152	1037	29886268
Extradural haematoma	27.68	11.02	22	65151	1167	29886138
Haemoptysis	27.39	11.02	137	65036	30941	29856364
Mediastinal haematoma	27.30	11.02	10	65163	103	29887202
Premature baby	27.11	11.02	89	65084	16602	29870703
Arthropathy	27.01	11.02	6	65167	20721	29866584
Haematocrit decreased	26.82	11.02	135	65038	30564	29856741
Respiratory distress	26.73	11.02	142	65031	32830	29854475
Vertigo	26.72	11.02	8	65165	22627	29864678
Complication associated with device	26.59	11.02	46	65127	5674	29881631
Pulmonary artery thrombosis	26.45	11.02	17	65156	643	29886662
Ischaemic hepatitis	26.35	11.02	24	65149	1535	29885770
Organ failure	26.34	11.02	28	65145	2163	29885142
Leg amputation	26.24	11.02	28	65145	2173	29885132
Livedo reticularis	26.21	11.02	28	65145	2176	29885129
Lymphocyte count decreased	26.08	11.02	96	65077	18959	29868346
Malignant neoplasm progression	26.06	11.02	76	65097	72211	29815094
Choroidal dystrophy	26.03	11.02	8	65165	45	29887260
Activated partial thromboplastin time abnormal	25.74	11.02	9	65164	80	29887225
Haemoperitoneum	25.64	11.02	23	65150	1442	29885863
Aneurysm ruptured	25.61	11.02	15	65158	479	29886826
Device related thrombosis	25.61	11.02	18	65155	791	29886514
Haematoma muscle	25.60	11.02	16	65157	576	29886729
Vision blurred	25.57	11.02	32	65141	41784	29845521
Choroidal infarction	25.26	11.02	9	65164	85	29887220
Hypercoagulation	25.26	11.02	20	65153	1055	29886250
Reperfusion injury	25.17	11.02	9	65164	86	29887219
Vasodilatation	25.13	11.02	19	65154	936	29886369
Palpitations	24.67	11.02	22	65151	33551	29853754
Hypertransaminasaemia	24.62	11.02	36	65137	3849	29883456
Tongue haematoma	24.49	11.02	10	65163	141	29887164
Acute right ventricular failure	24.38	11.02	9	65164	95	29887210
Ventricular extrasystoles	24.12	11.02	67	65106	11407	29875898
Prostate cancer	24.03	11.02	11	65162	23946	29863359
Disease progression	23.97	11.02	91	65082	79783	29807522
Red blood cells urine positive	23.70	11.02	23	65150	1594	29885711
Embolic stroke	23.59	11.02	34	65139	3588	29883717
Haemolysis	23.55	11.02	50	65123	7181	29880124
Sleep disorder	23.39	11.02	12	65161	24467	29862838
Psychotic disorder	22.98	11.02	9	65164	21506	29865799
Dyspnoea exertional	22.85	11.02	26	65147	35404	29851901
Tremor	22.52	11.02	86	65087	75277	29812028
Abnormal behaviour	22.42	11.02	14	65159	25609	29861696
Basal cell carcinoma	22.30	11.02	4	65169	16064	29871241
Coronary artery stenosis	22.15	11.02	56	65117	9014	29878291
Jugular vein thrombosis	22.14	11.02	21	65152	1415	29885890
Spinal epidural haematoma	22.07	11.02	10	65163	184	29887121
Cognitive disorder	22.07	11.02	12	65161	23678	29863627
Treatment noncompliance	21.82	11.02	14	65159	25239	29862066
Plasma cell myeloma	21.69	11.02	53	65120	53409	29833896
Inappropriate schedule of product administration	21.69	11.02	33	65140	39695	29847610
Full blood count decreased	21.62	11.02	4	65169	15713	29871592
Lower respiratory tract infection	21.50	11.02	16	65157	26698	29860607
Visual impairment	21.12	11.02	21	65152	30417	29856888
Dysgeusia	21.09	11.02	14	65159	24787	29862518
Wrong technique in product usage process	21.05	11.02	22	65151	31133	29856172
Blood pressure fluctuation	21.00	11.02	6	65167	17497	29869808
Abdominal pain upper	20.95	11.02	68	65105	62483	29824822
Suspected transmission of an infectious agent via product	20.93	11.02	13	65160	463	29886842
Vessel puncture site haematoma	20.89	11.02	7	65166	54	29887251
Osteoarthritis	20.75	11.02	7	65166	18342	29868963
Coronary artery embolism	20.62	11.02	9	65164	151	29887154
Haemorrhagic stroke	20.60	11.02	43	65130	6104	29881201
Cerebral haematoma	20.59	11.02	36	65137	4478	29882827
Platelet factor 4 increased	20.53	11.02	4	65169	0	29887305
Confusional state	20.49	11.02	191	64982	134643	29752662
Intrapericardial thrombosis	20.46	11.02	7	65166	58	29887247
Arthritis	20.44	11.02	14	65159	24387	29862918
Renal infarct	20.31	11.02	18	65155	1111	29886194
Prothrombin time prolonged	20.23	11.02	55	65118	9248	29878057
Road traffic accident	20.21	11.02	6	65167	17065	29870240
Oedema peripheral	20.18	11.02	141	65032	105691	29781614
Peripheral artery occlusion	20.14	11.02	20	65153	1426	29885879
Blood urea increased	20.12	11.02	127	65046	31254	29856051
Rhinorrhoea	20.09	11.02	10	65163	20744	29866561
Respiratory tract oedema	20.00	11.02	12	65161	401	29886904
Renal artery thrombosis	19.90	11.02	11	65162	314	29886991
Influenza like illness	19.76	11.02	16	65157	25589	29861716
Eosinophilia	19.74	11.02	98	65075	22062	29865243
Product quality issue	19.64	11.02	87	65086	18687	29868618
Intentional self-injury	19.60	11.02	3	65170	13529	29873776
Abdominal wall haematoma	19.57	11.02	21	65152	1640	29885665
Haematemesis	19.33	11.02	110	65063	26093	29861212
Wound evisceration	19.32	11.02	8	65165	117	29887188
Budd-Chiari syndrome	19.29	11.02	5	65168	13	29887292
Tracheal haemorrhage	19.28	11.02	12	65161	429	29886876
Reperfusion arrhythmia	19.21	11.02	7	65166	71	29887234
Psychological trauma	19.09	11.02	9	65164	182	29887123
Mouth haemorrhage	19.09	11.02	37	65136	4980	29882325
Platelet disorder	19.09	11.02	18	65155	1204	29886101
Prosthetic cardiac valve thrombosis	19.02	11.02	5	65168	14	29887291
Paraesthesia	18.94	11.02	58	65115	54269	29833036
Petechiae	18.88	11.02	53	65120	9078	29878227
Device related sepsis	18.87	11.02	24	65149	2248	29885057
Product complaint	18.74	11.02	40	65133	5766	29881539
Loss of personal independence in daily activities	18.52	11.02	12	65161	21523	29865782
Drug withdrawal syndrome	18.50	11.02	10	65163	19799	29867506
Cerebral hyperperfusion syndrome	18.38	11.02	7	65166	81	29887224
Hypoxic-ischaemic encephalopathy	18.36	11.02	35	65138	4652	29882653
Appendicitis	18.32	11.02	41	65132	6103	29881202
Hydrocephalus	18.31	11.02	33	65140	4204	29883101
Hand amputation	18.30	11.02	4	65169	3	29887302
Haemorrhage coronary artery	18.29	11.02	5	65168	17	29887288
Pulmonary fibrosis	18.07	11.02	6	65167	15884	29871421
Mixed liver injury	18.07	11.02	22	65151	1971	29885334
Osteonecrosis of jaw	17.98	11.02	9	65164	18609	29868696
White blood cell count decreased	17.95	11.02	108	65065	83839	29803466
Vomiting	17.89	11.02	354	64819	219464	29667841
Vascular access site haematoma	17.77	11.02	4	65169	4	29887301
Intra-abdominal haematoma	17.75	11.02	18	65155	1316	29885989
Pruritus	17.71	11.02	168	65005	118036	29769269
Platelet aggregation abnormal	17.66	11.02	5	65168	20	29887285
Aplastic anaemia	17.62	11.02	38	65135	5518	29881787
Nikolsky's sign	17.51	11.02	9	65164	221	29887084
Gastrooesophageal reflux disease	17.41	11.02	27	65146	32228	29855077
Ventricular asystole	17.33	11.02	8	65165	154	29887151
Microstomia	17.30	11.02	4	65169	5	29887300
Foetal exposure timing unspecified	17.25	11.02	9	65164	228	29887077
Necrosis ischaemic	17.22	11.02	9	65164	229	29887076
Hemiplegia	17.19	11.02	42	65131	6619	29880686
Pneumonia	17.16	11.02	576	64597	333730	29553575
Back pain	17.05	11.02	142	65031	102454	29784851
Peliosis hepatis	17	11.02	6	65167	55	29887250
Anticoagulation drug level below therapeutic	16.99	11.02	13	65160	652	29886653
Drug reaction with eosinophilia and systemic symptoms	16.86	11.02	113	65060	28375	29858930
Thrombotic microangiopathy	16.85	11.02	49	65124	8561	29878744
Head injury	16.78	11.02	8	65165	17012	29870293
Nightmare	16.77	11.02	3	65170	12073	29875232
Coronary artery dissection	16.61	11.02	8	65165	170	29887135
Medical device site thrombosis	16.60	11.02	5	65168	26	29887279
Hemiparesis	16.56	11.02	70	65103	14732	29872573
Subcutaneous haematoma	16.56	11.02	15	65158	953	29886352
Nasal congestion	16.44	11.02	10	65163	18556	29868749
Cataract	16.41	11.02	14	65159	21821	29865484
Rash maculo-papular	16.37	11.02	103	65070	25315	29861990
Incorrect drug administration rate	16.36	11.02	16	65157	1120	29886185
Subdural haematoma	16.27	11.02	83	65090	18889	29868416
Eye excision	16.14	11.02	5	65168	29	29887276
Contrast media reaction	16.06	11.02	14	65159	845	29886460
Foot amputation	16.05	11.02	11	65162	464	29886841
Gastrointestinal necrosis	16.01	11.02	27	65146	3262	29884043
Blood culture positive	16.01	11.02	34	65139	4885	29882420
Bronchial haemorrhage	15.93	11.02	13	65160	716	29886589
Therapeutic product effect decreased	15.83	11.02	113	65060	28963	29858342
Therapeutic product effect incomplete	15.82	11.02	31	65142	33803	29853502
Penile necrosis	15.79	11.02	6	65167	69	29887236
Hepatic haematoma	15.78	11.02	11	65162	477	29886828
Erectile dysfunction	15.69	11.02	10	65163	18092	29869213
Dry mouth	15.59	11.02	16	65157	22834	29864471
Coronary artery aneurysm	15.49	11.02	6	65167	73	29887232
Constipation	15.45	11.02	164	65009	112742	29774563
Bullous haemorrhagic dermatosis	15.40	11.02	3	65170	0	29887305
Anisochromia	15.40	11.02	3	65170	0	29887305
Autoimmune heparin-induced thrombocytopenia	15.40	11.02	3	65170	0	29887305
Acquired antithrombin III deficiency	15.40	11.02	3	65170	0	29887305
Chest wall haematoma	15.30	11.02	7	65166	132	29887173
Osteonecrosis	15.28	11.02	8	65165	16127	29871178
Fat embolism	15.18	11.02	8	65165	207	29887098
Drug ineffective	15.09	11.02	597	64576	339790	29547515
Right ventricular failure	15.03	11.02	45	65128	7991	29879314
Orthostatic hypotension	15.03	11.02	18	65155	23961	29863344
Continuous haemodiafiltration	14.91	11.02	15	65158	1086	29886219
Traumatic liver injury	14.81	11.02	8	65165	218	29887087
Thyroid haemorrhage	14.77	11.02	4	65169	13	29887292
Myiasis	14.77	11.02	4	65169	13	29887292
Interstitial lung disease	14.75	11.02	74	65099	60123	29827182
Hypoxia	14.65	11.02	164	65009	47690	29839615
Delusion	14.59	11.02	4	65169	11985	29875320
Mean cell haemoglobin concentration	14.55	11.02	5	65168	42	29887263
Primary adrenal insufficiency	14.54	11.02	4	65169	14	29887291
Incision site haematoma	14.54	11.02	6	65167	87	29887218
Poor quality product administered	14.45	11.02	18	65155	1651	29885654
Serratia infection	14.41	11.02	12	65161	680	29886625
Mean arterial pressure decreased	14.40	11.02	7	65166	152	29887153
Fluid retention	14.39	11.02	20	65153	24978	29862327
Diabetes mellitus	14.38	11.02	45	65128	41820	29845485
Syncope	14.33	11.02	117	65056	84786	29802519
Coronary bypass thrombosis	14.33	11.02	4	65169	15	29887290
Foetal growth restriction	14.33	11.02	27	65146	3558	29883747
Hot flush	14.32	11.02	7	65166	14673	29872632
Coronary artery occlusion	14.26	11.02	55	65118	11102	29876203
Brain death	14.14	11.02	22	65151	2484	29884821
Device occlusion	14.13	11.02	37	65136	6083	29881222
Urea renal clearance decreased	14.13	11.02	4	65169	16	29887289
Complications of transplanted kidney	14.11	11.02	29	65144	4072	29883233
Fungal sepsis	13.99	11.02	12	65161	709	29886596
Depressed mood	13.96	11.02	10	65163	17019	29870286
Dialysis	13.89	11.02	54	65119	10942	29876363
Tinnitus	13.79	11.02	9	65164	16079	29871226
Antithrombin III deficiency	13.78	11.02	6	65167	100	29887205
Blood creatine phosphokinase MB increased	13.68	11.02	19	65154	1937	29885368
Monoplegia	13.56	11.02	16	65157	1387	29885918
Visual acuity reduced	13.40	11.02	9	65164	15837	29871468
Anticoagulation drug level above therapeutic	13.38	11.02	18	65155	1781	29885524
Platelet aggregation test	13.36	11.02	5	65168	55	29887250
Bone pain	13.35	11.02	13	65160	19013	29868292
Hepatitis C	13.34	11.02	6	65167	13199	29874106
Heart rate irregular	13.31	11.02	5	65168	12254	29875051
Cerebral artery occlusion	13.28	11.02	12	65161	760	29886545
Renal tubular necrosis	13.27	11.02	67	65106	15184	29872121
Venous thrombosis limb	13.26	11.02	18	65155	1796	29885509
Withdrawal syndrome	13.24	11.02	4	65169	11246	29876059
Palmar-plantar erythrodysaesthesia syndrome	13.18	11.02	8	65165	14862	29872443
Aortic dissection	13.18	11.02	21	65152	2421	29884884
Ischaemic stroke	13.12	11.02	70	65103	16205	29871100
Finger amputation	13.08	11.02	7	65166	187	29887118
Distributive shock	13.04	11.02	11	65162	635	29886670
Accidental exposure to product	13.03	11.02	3	65170	10112	29877193
Epistaxis	12.94	11.02	174	64999	52807	29834498
Hypertension	12.93	11.02	186	64987	121168	29766137
Chronic obstructive pulmonary disease	12.91	11.02	54	65119	46072	29841233
Arterial injury	12.80	11.02	8	65165	288	29887017
Metastases to liver	12.79	11.02	5	65168	11960	29875345
Sopor	12.77	11.02	4	65169	10987	29876318
Renal haemorrhage	12.71	11.02	15	65158	1300	29886005
Pulmonary oedema	12.70	11.02	149	65024	43826	29843479
Acute respiratory failure	12.67	11.02	98	65075	25752	29861553
Ecchymosis	12.65	11.02	37	65136	6485	29880820
Pericardial effusion	12.59	11.02	84	65089	21060	29866245
Pulse absent	12.55	11.02	33	65140	5440	29881865
Type 2 diabetes mellitus	12.54	11.02	7	65166	13615	29873690
Cerebral venous sinus thrombosis	12.48	11.02	8	65165	301	29887004
Respiratory gas exchange disorder	12.46	11.02	9	65164	413	29886892
Necrotising oesophagitis	12.42	11.02	9	65164	415	29886890
Hallucination, auditory	12.42	11.02	3	65170	9786	29877519
Neutrophil count increased	12.42	11.02	66	65107	15257	29872048
Carotid artery dissection	12.40	11.02	6	65167	129	29887176
Agitation	12.39	11.02	68	65105	54005	29833300
Hepatic cirrhosis	12.34	11.02	10	65163	15989	29871316
Alveolitis necrotising	12.27	11.02	4	65169	28	29887277
Venous haemorrhage	12.27	11.02	4	65169	28	29887277
Atrial fibrillation	12.25	11.02	315	64858	107809	29779496
Cyanosis	12.25	11.02	55	65118	11880	29875425
Immune effector cell-associated neurotoxicity syndrome	12.22	11.02	12	65161	844	29886461
Ischaemia	12.19	11.02	29	65144	4492	29882813
Blood pressure increased	12.19	11.02	99	65074	71829	29815476
Bronchitis	12.10	11.02	44	65129	39081	29848224
Haemodialysis	12.10	11.02	52	65121	11021	29876284
Graft loss	12.06	11.02	12	65161	858	29886447
Bradycardia	12.05	11.02	205	64968	65321	29821984
Haemorrhagic disorder	12.04	11.02	10	65163	565	29886740
Apgar score abnormal	12.04	11.02	4	65169	30	29887275
Hypoacusis	11.99	11.02	8	65165	14131	29873174
Retinoblastoma	11.92	11.02	4	65169	31	29887274
International normalised ratio decreased	11.90	11.02	29	65144	4561	29882744
Myelodysplastic syndrome	11.87	11.02	14	65159	18764	29868541
Cerebrovascular accident	11.86	11.02	251	64922	83226	29804079
Iliac artery occlusion	11.83	11.02	6	65167	143	29887162
Anti factor Xa activity decreased	11.80	11.02	3	65170	7	29887298
Burkholderia test positive	11.79	11.02	9	65164	450	29886855
Electrocardiogram ST segment abnormal	11.78	11.02	10	65163	582	29886723
Hypovolaemic shock	11.78	11.02	36	65137	6464	29880841
Diabetes insipidus	11.73	11.02	19	65154	2220	29885085
Peritoneal dialysis complication	11.71	11.02	27	65146	4100	29883205
Peripheral arterial occlusive disease	11.68	11.02	31	65142	5137	29882168
Amnesia	11.62	11.02	22	65151	24299	29863006
Neuroleptic malignant syndrome	11.59	11.02	11	65162	16284	29871021
Therapeutic product ineffective	11.57	11.02	10	65163	597	29886708
Iatrogenic injury	11.56	11.02	11	65162	744	29886561
Tachycardia	11.56	11.02	225	64948	73514	29813791
Cerebral artery embolism	11.56	11.02	12	65161	902	29886403
Disability	11.55	11.02	28	65145	4390	29882915
Splenic haematoma	11.54	11.02	6	65167	151	29887154
Injection site erythema	11.50	11.02	8	65165	13826	29873479
Vessel puncture site haemorrhage	11.50	11.02	5	65168	83	29887222
Inferior vena caval occlusion	11.50	11.02	4	65169	35	29887270
Transplant failure	11.46	11.02	20	65153	2484	29884821
Atelectasis	11.41	11.02	67	65106	16071	29871234
Cardiac perforation	11.40	11.02	5	65168	85	29887220
Nephrolithiasis	11.37	11.02	23	65150	24787	29862518
Localised infection	11.35	11.02	8	65165	13729	29873576
Pollakiuria	11.35	11.02	12	65161	16894	29870411
Paranoia	11.32	11.02	4	65169	10184	29877121
Melaena	11.25	11.02	114	65059	32323	29854982
Dermatitis bullous	11.24	11.02	34	65139	6070	29881235
Brain stem infarction	11.17	11.02	14	65159	1292	29886013
Protein urine present	11.16	11.02	29	65144	4746	29882559
Contrast encephalopathy	11.12	11.02	4	65169	39	29887266
Neonatal respiratory distress syndrome	11.11	11.02	26	65147	3986	29883319
Product prescribing error	11.10	11.02	12	65161	16721	29870584
Upper gastrointestinal haemorrhage	11.07	11.02	84	65089	21944	29865361
Haemodialysis complication	11.04	11.02	5	65168	92	29887213

Pharmacologic Action:

Source	Code	Description
ATC	B01AB01	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Heparin group
ATC	C05BA03	CARDIOVASCULAR SYSTEM VASOPROTECTIVES ANTIVARICOSE THERAPY Heparins or heparinoids for topical use
ATC	S01XA14	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
ATC	B01AB51	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Heparin group
ATC	C05BA53	CARDIOVASCULAR SYSTEM VASOPROTECTIVES ANTIVARICOSE THERAPY Heparins or heparinoids for topical use
FDA CS	M0010187	Heparin
FDA EPC	N0000175474	Unfractionated Heparin
MeSH PA	D000925	Anticoagulants
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D005343	Fibrinolytic Agents
MeSH PA	D006401	Hematologic Agents
FDA EPC	N0000175980	Anti-coagulant
CHEBI has role	CHEBI:50249	anticoagulante

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Disseminated intravascular coagulation	indication	67406007	DOID:11247
Deep venous thrombosis	indication	128053003
Pulmonary thromboembolism	indication	233935004
Peripheral arterial embolism	indication	286959000
Non-Q wave myocardial infarction	indication	314207007
Prevention of deep vein thrombosis	indication	439993001
Deep Vein Thrombosis with Pulmonary Embolism	indication
Prevention of Recurrent Venous Thrombosis Associated with Malignancy	indication
Pulmonary Thromboembolism Prevention	indication
Peripheral Arterial Thromboembolism Prevention	indication
Maintain Patency of Indwelling Vascular Catheter	indication
Prevention of Ischemic Complications of Non-Q Wave MI	indication
Prevention of Cardiac Ischemia in Unstable Angina	indication
Myocardial infarction	off-label use	22298006	DOID:5844
Coronavirus infection	off-label use	186747009
Acute coronary syndrome	off-label use	394659003
Percutaneous coronary intervention	off-label use	415070008
Intracranial hemorrhage	contraindication	1386000
Diabetic retinopathy	contraindication	4855003	DOID:8947
Hypertensive retinopathy	contraindication	6962006	DOID:11561
Retinal disorder	contraindication	29555009	DOID:5679
Antithrombin III deficiency	contraindication	36351005	DOID:3755
Gastrointestinal ulcer	contraindication	40845000
Threatened abortion	contraindication	54048003	DOID:9667
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Ulcerative colitis	contraindication	64766004	DOID:8577
Blood coagulation disorder	contraindication	64779008	DOID:1247
Osteoporosis	contraindication	64859006	DOID:11476
Operation on brain	contraindication	70586009
Heparin-induced thrombocytopenia	contraindication	73397007
Gastrointestinal hemorrhage	contraindication	74474003
Ulceration of intestine	contraindication	85942002
Acute gastric ulcer with hemorrhage	contraindication	89748001
Hemophilia	contraindication	90935002
Disorder of biliary tract	contraindication	105997008	DOID:9741
Procedure on central nervous system	contraindication	118679007
Bleeding	contraindication	131148009
Disease of blood AND/OR blood-forming organ	contraindication	191124002	DOID:74
Hemorrhagic cerebral infarction	contraindication	230706003
Local anesthetic intrathecal block	contraindication	231249005
Infective endocarditis	contraindication	233850007
Procedure on spine	contraindication	238181003
Qualitative platelet disorder	contraindication	267532001
Diverticulitis of gastrointestinal tract	contraindication	271366000
Cerebral hemorrhage	contraindication	274100004
Lumbar puncture	contraindication	277762005
Bacterial endocarditis	contraindication	301183007
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Dissection of aorta	contraindication	308546005
Arteriosclerosis obliterans	contraindication	361133006	DOID:5160
Surgical procedure on eye proper	contraindication	373353005
Hypertensive urgency	contraindication	443482000
Placement of Epidural Catheter	contraindication
Thrombosis in Heparin Induced Thrombocytopenia	contraindication
Platelet Aggregation Inhibition	contraindication
Spinal Epidural Hematoma	contraindication
Significant Bleeding	contraindication
Indwelling Vascular Catheter	contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Antithrombin-III	Secreted	P01008	ANT3_HUMAN	ACTIVATOR	Kd	7.85		IUPHAR	CHEMBL

External reference:

ID	Source
D02112	KEGG_DRUG
37270-89-6	SECONDARY_CAS_RN
4017546	VANDF
4017547	VANDF
4017549	VANDF
4018538	VANDF
C0019134	UMLSCUI
CHEBI:28304	CHEBI
M7J	PDB_CHEM_ID
CHEMBL1909300	ChEMBL_ID
CHEMBL1201513	ChEMBL_ID
CHEMBL1201657	ChEMBL_ID
DB01109	DRUGBANK_ID
D006493	MESH_DESCRIPTOR_UI
4214	IUPHAR_LIGAND_ID
392	INN_ID
T2410KM04A	UNII
772	PUBCHEM_CID
20044	RXNORM
3649	MMSL
4821	MMSL
d00252	MMSL
002079	NDDF
002081	NDDF
015153	NDDF
29725000	SNOMEDCT_US
372877000	SNOMEDCT_US
412201008	SNOMEDCT_US
412401006	SNOMEDCT_US
50045009	SNOMEDCT_US
784398008	SNOMEDCT_US
84812008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0043	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0058	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0059	INJECTION	5000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0062	INJECTION	10000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0137	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0264-5705	INJECTION	5000 [USPU]	INTRAVENOUS	ANDA	20 sections
Heparin Sodium in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	2	0264-9567	INJECTION	4000 [USPU]	INTRAVENOUS	NDA	19 sections
Heparin Sodium in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	2	0264-9577	INJECTION	5000 [USPU]	INTRAVENOUS	NDA	19 sections
Heparin Sodium in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	2	0264-9587	INJECTION	10000 [USPU]	INTRAVENOUS	NDA	19 sections
Heparin Sodium in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	0264-9872	INJECTION	200 [USPU]	INTRAVENOUS	NDA	23 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0424	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA authorized generic	25 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0428	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	25 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0431	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	25 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0433	INJECTION, SOLUTION	200 [USPU]	INTRAVESICAL	NDA	25 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-1316	INJECTION, SOLUTION	10000 [USPU]	SUBCUTANEOUS	ANDA	25 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-1402	INJECTION, SOLUTION	5000 [USPU]	SUBCUTANEOUS	ANDA	25 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-2720	INJECTION, SOLUTION	1000 [USPU]	SUBCUTANEOUS	ANDA	25 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-2721	INJECTION, SOLUTION	10000 [USPU]	INTRAVENOUS	ANDA	25 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-2723	INJECTION, SOLUTION	5000 [USPU]	SUBCUTANEOUS	ANDA	25 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-7620	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	27 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-7650	INJECTION, SOLUTION	10000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0409-7651	INJECTION, SOLUTION	5000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium and Dextrose	HUMAN PRESCRIPTION DRUG LABEL	1	0409-7793	INJECTION, SOLUTION	10000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium and Dextrose	HUMAN PRESCRIPTION DRUG LABEL	1	0409-7794	INJECTION, SOLUTION	5000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0641-0391	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0641-0400	INJECTION	5000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0641-0410	INJECTION	10000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0641-2450	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0641-2460	INJECTION	5000 [USPU]	INTRAVENOUS	NDA	24 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6199	INJECTION	5000 [USPU]	INTRAVENOUS	NDA	24 sections