heparin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
heparin derivatives including low molecular mass heparins 1358 9005-49-6

Description:

MoleculeDescription

Synonyms:

  • heparin
  • heparin sodium
  • heparin calcium
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts. Also,in conjunction with taurolidine, has received FDA approval for diminishing the occurrence of catheter-related bloodstream infections in adult patients undergoing chronic hemodialysis with a central venous catheter (CVC) and experiencing kidney failure.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
10 TU P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Feb. 9, 1939 FDA ORGANON USA INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heparin-induced thrombocytopenia 3793.53 11.13 862 66237 4450 90556898
Premature delivery 552.35 11.13 349 66750 38413 90522935
Shock haemorrhagic 385.25 11.13 186 66913 12059 90549289
Haemorrhage 347.06 11.13 336 66763 69033 90492315
Hereditary angioedema 293.83 11.13 142 66957 9223 90552125
Thrombocytopenia 287.51 11.13 537 66562 208188 90353160
Haematoma 282.46 11.13 233 66866 38815 90522533
Cerebral haemorrhage 266.57 11.13 214 66885 34308 90527040
Pulmonary embolism 246.56 11.13 387 66712 130433 90430915
Labelled drug-drug interaction medication error 239.98 11.13 144 66955 14438 90546910
Retroperitoneal haemorrhage 235.80 11.13 88 67011 2992 90558356
Joint swelling 235.44 11.13 44 67055 503256 90058092
Retroperitoneal haematoma 231.72 11.13 89 67010 3279 90558069
Arthropathy 228.67 11.13 10 67089 366232 90195116
Rheumatoid arthritis 219.67 11.13 12 67087 362602 90198746
Vascular stent thrombosis 219.60 11.13 65 67034 1051 90560297
Abdominal wall haematoma 217.90 11.13 85 67014 3267 90558081
Exposure during pregnancy 217.06 11.13 518 66581 237892 90323456
Pemphigus 214.24 11.13 6 67093 326858 90234490
Acute kidney injury 207.27 11.13 613 66486 319774 90241574
Haemorrhage intracranial 199.75 11.13 130 66969 15032 90546316
Maternal exposure during pregnancy 194.34 11.13 647 66452 359416 90201932
Alopecia 191.53 11.13 64 67035 495007 90066341
Haematoma muscle 191.16 11.13 66 67033 1784 90559564
Drug intolerance 187.41 11.13 50 67049 447541 90113807
Pericarditis 173.25 11.13 6 67093 270145 90291203
Cardiac arrest 172.65 11.13 292 66807 104643 90456705
Systemic lupus erythematosus 170.50 11.13 31 67068 361865 90199483
Thrombosis 167.00 11.13 237 66862 73014 90488334
Arthralgia 162.60 11.13 203 66896 778319 89783029
Premature baby 161.52 11.13 140 66959 24937 90536411
Multiple organ dysfunction syndrome 158.60 11.13 223 66876 68113 90493235
Psoriatic arthropathy 154.16 11.13 3 67096 228332 90333016
Abdominal discomfort 153.63 11.13 81 67018 477247 90084101
Thrombosis in device 151.82 11.13 64 67035 3011 90558337
Wound 146.98 11.13 24 67075 302956 90258392
Cerebral infarction 146.61 11.13 136 66963 26460 90534888
Haemoperitoneum 146.57 11.13 65 67034 3463 90557885
Toxic epidermal necrolysis 139.50 11.13 145 66954 32383 90528965
Duodenal ulcer perforation 138.18 11.13 6 67093 221282 90340066
Hypotension 135.81 11.13 538 66561 324859 90236489
Spinal epidural haematoma 135.54 11.13 47 67052 1287 90560061
Cardiogenic shock 132.72 11.13 124 66975 24344 90537004
Deep vein thrombosis 128.79 11.13 238 66861 91382 90469966
Haemoglobin decreased 127.38 11.13 333 66766 161623 90399725
Activated partial thromboplastin time prolonged 125.46 11.13 76 67023 7749 90553599
Sepsis 121.79 11.13 350 66749 179464 90381884
Folliculitis 119.93 11.13 8 67091 204345 90357003
Irritable bowel syndrome 119.21 11.13 9 67090 207439 90353909
Haemothorax 118.29 11.13 50 67049 2368 90558980
Low birth weight baby 116.99 11.13 78 67021 9389 90551959
Hypersensitivity 114.46 11.13 101 66998 454576 90106772
Type 2 diabetes mellitus 113.51 11.13 10 67089 203234 90358114
Vascular pseudoaneurysm 113.08 11.13 44 67055 1679 90559669
Hepatic enzyme increased 111.95 11.13 64 67035 360672 90200676
Coagulopathy 111.15 11.13 110 66989 23179 90538169
Heparin resistance 109.45 11.13 21 67078 36 90561312
Respiratory failure 109.44 11.13 259 66840 118159 90443189
Mobility decreased 108.72 11.13 26 67073 250708 90310640
Extradural haematoma 108.68 11.13 45 67054 2023 90559325
Musculoskeletal stiffness 108.32 11.13 42 67057 296490 90264858
Impaired healing 106.15 11.13 22 67077 234177 90327171
Blood cholesterol increased 104.22 11.13 15 67084 207997 90353351
Swelling 103.17 11.13 95 67004 418963 90142385
Eosinophilia 102.76 11.13 116 66983 28417 90532931
Aplastic anaemia 97.64 11.13 80 67019 13189 90548159
Stevens-Johnson syndrome 96.67 11.13 114 66985 29262 90532086
Disseminated intravascular coagulation 95.94 11.13 98 67001 21440 90539908
Peripheral ischaemia 93.33 11.13 56 67043 5611 90555737
Treatment failure 92.75 11.13 55 67044 303873 90257475
Lower respiratory tract infection 92.37 11.13 35 67064 250624 90310724
Fibromyalgia 92.19 11.13 20 67079 206249 90355099
Discomfort 92.00 11.13 44 67055 274291 90287057
Gastrointestinal haemorrhage 91.78 11.13 205 66894 90043 90471305
Cardiac tamponade 91.06 11.13 55 67044 5577 90555771
Pharyngeal haemorrhage 90.09 11.13 29 67070 627 90560721
Subdural haematoma 89.58 11.13 84 67015 16561 90544787
Pericardial haemorrhage 89.14 11.13 38 67061 1838 90559510
Anaemia 87.59 11.13 502 66597 352300 90209048
Ill-defined disorder 84.54 11.13 17 67082 184874 90376474
Pain 84.16 11.13 416 66683 995925 89565423
Encephalopathy 84.09 11.13 135 66964 46309 90515039
Intracardiac thrombus 83.65 11.13 39 67060 2335 90559013
Injury 82.57 11.13 22 67077 197327 90364021
Foetal exposure during pregnancy 82.06 11.13 128 66971 42847 90518501
Compartment syndrome 81.93 11.13 41 67058 2871 90558477
Hypoxia 81.08 11.13 171 66928 72228 90489120
Heparin-induced thrombocytopenia test positive 80.61 11.13 14 67085 8 90561340
Upper gastrointestinal haemorrhage 75.33 11.13 89 67010 22887 90538461
Joint range of motion decreased 74.85 11.13 7 67092 135636 90425712
Osteoarthritis 74.35 11.13 26 67073 195704 90365644
Haemorrhagic transformation stroke 74.17 11.13 30 67069 1269 90560079
Coagulation time prolonged 72.99 11.13 32 67067 1658 90559690
Rash 72.67 11.13 323 66776 795777 89765571
Memory impairment 71.89 11.13 28 67071 197216 90364132
Haemodynamic instability 70.51 11.13 63 67036 11676 90549672
Subarachnoid haemorrhage 70.00 11.13 76 67023 17828 90543520
Orbital compartment syndrome 69.77 11.13 16 67083 86 90561262
Embolism 69.42 11.13 57 67042 9424 90551924
Psoriasis 68.77 11.13 13 67086 147741 90413607
Oesophageal intramural haematoma 68.64 11.13 17 67082 133 90561215
Pulmonary alveolar haemorrhage 68.34 11.13 47 67052 5951 90555397
Blood pressure decreased 68.29 11.13 163 66936 74732 90486616
Platelet count decreased 67.45 11.13 239 66860 136730 90424618
Aortic thrombosis 67.09 11.13 28 67071 1284 90560064
Bursitis 67.09 11.13 9 67090 131645 90429703
Contraindicated product administered 66.06 11.13 84 67015 320055 90241293
Gastrointestinal disorder 65.75 11.13 56 67043 256631 90304717
Muscle haemorrhage 65.53 11.13 37 67062 3309 90558039
Acute myocardial infarction 65.34 11.13 103 66996 34787 90526561
Caesarean section 64.30 11.13 74 67025 18503 90542845
Arthritis 63.93 11.13 22 67077 167293 90394055
Coronary artery thrombosis 63.92 11.13 26 67073 1116 90560232
Rash maculo-papular 63.45 11.13 111 66988 40822 90520526
Hyperkalaemia 63.18 11.13 145 66954 64819 90496529
Completed suicide 62.93 11.13 15 67084 145043 90416305
Inflammation 62.41 11.13 27 67072 178565 90382783
Septic shock 62.02 11.13 169 66930 83991 90477357
Cerebral haematoma 62.00 11.13 39 67060 4250 90557098
Off label use 61.38 11.13 1150 65949 1101102 89460246
Depression 60.86 11.13 80 67019 300521 90260827
Asthma 60.61 11.13 54 67045 242106 90319242
Brain herniation 60.24 11.13 38 67061 4162 90557186
Venous thrombosis 59.84 11.13 42 67057 5495 90555853
Epistaxis 59.82 11.13 168 66931 84957 90476391
Subchorionic haematoma 59.73 11.13 15 67084 125 90561223
Procedural haemorrhage 59.71 11.13 34 67065 3090 90558258
Spinal cord compression 59.57 11.13 40 67059 4871 90556477
Splenic rupture 59.34 11.13 26 67073 1345 90560003
Adrenal haemorrhage 59.21 11.13 20 67079 505 90560843
Infective aneurysm 58.67 11.13 19 67080 419 90560929
Wheezing 58.50 11.13 54 67045 238026 90323322
Fatigue 57.63 11.13 562 66537 1153461 89407887
Vena cava thrombosis 57.63 11.13 31 67068 2521 90558827
Catheter site haemorrhage 57.19 11.13 35 67064 3633 90557715
Ischaemic stroke 56.93 11.13 76 67023 22090 90539258
Blister 56.77 11.13 63 67036 254935 90306413
Stomatitis 56.74 11.13 72 67027 274626 90286722
Coagulation time shortened 56.58 11.13 15 67084 158 90561190
Grip strength decreased 56.19 11.13 3 67096 92573 90468775
Confusional state 56.05 11.13 127 66972 386078 90175270
Peripheral artery thrombosis 56.01 11.13 29 67070 2181 90559167
Oliguria 55.99 11.13 53 67046 10571 90550777
Haemorrhagic infarction 55.47 11.13 17 67082 311 90561037
Sleep disorder 54.74 11.13 40 67059 197990 90363358
Gait inability 54.68 11.13 20 67079 146436 90414912
Insurance issue 54.60 11.13 53 67046 10905 90550443
Night sweats 54.53 11.13 14 67085 128752 90432596
Facet joint syndrome 54.49 11.13 5 67094 98384 90462964
Pulmonary fibrosis 53.25 11.13 8 67091 107495 90453853
Foetal death 53.14 11.13 71 67028 20652 90540696
Insomnia 53.13 11.13 104 66995 333370 90227978
Hypercoagulation 52.78 11.13 28 67071 2214 90559134
Post procedural haemorrhage 52.41 11.13 47 67052 8751 90552597
Product use in unapproved indication 52.03 11.13 426 66673 335810 90225538
Obesity 51.92 11.13 8 67091 105499 90455849
Bullous haemorrhagic dermatosis 51.59 11.13 15 67084 227 90561121
Vaginal haemorrhage 51.36 11.13 87 67012 31184 90530164
Peripheral swelling 51.34 11.13 147 66952 412959 90148389
Therapeutic product effect incomplete 51.26 11.13 41 67058 193855 90367493
Therapeutic product effect decreased 51.10 11.13 79 67020 277492 90283856
Respiratory distress 50.76 11.13 98 67001 38848 90522500
Pulseless electrical activity 49.85 11.13 46 67053 8886 90552462
Transfusion 49.65 11.13 63 67036 17425 90543923
Skin necrosis 49.64 11.13 62 67037 16879 90544469
Arterial thrombosis 49.40 11.13 24 67075 1576 90559772
Adverse event 49.27 11.13 13 67086 117405 90443943
Sciatica 49.18 11.13 8 67091 101374 90459974
Acute motor-sensory axonal neuropathy 49.14 11.13 16 67083 359 90560989
Pulmonary infarction 48.72 11.13 29 67070 2863 90558485
Shock 48.50 11.13 81 67018 28697 90532651
Intraventricular haemorrhage 47.53 11.13 27 67072 2442 90558906
Weight increased 47.45 11.13 155 66944 417772 90143576
Cardiac ventricular thrombosis 47.45 11.13 21 67078 1113 90560235
Choroidal infarction 47.26 11.13 12 67087 105 90561243
Atrial thrombosis 47.17 11.13 26 67073 2219 90559129
Electrocardiogram ST segment elevation 47.01 11.13 32 67067 3984 90557364
Antiphospholipid syndrome 46.85 11.13 26 67073 2248 90559100
Injection site pain 46.83 11.13 36 67063 173663 90387685
Acute generalised exanthematous pustulosis 46.45 11.13 54 67045 13649 90547699
Intentional overdose 46.44 11.13 7 67092 93827 90467521
Dyspepsia 46.29 11.13 47 67052 198113 90363235
Orbital haematoma 46.01 11.13 9 67090 18 90561330
Hypoaldosteronism 45.76 11.13 15 67084 344 90561004
Splenic infarction 45.70 11.13 25 67074 2102 90559246
Drug reaction with eosinophilia and systemic symptoms 45.57 11.13 99 67000 42659 90518689
Vascular access site haemorrhage 45.20 11.13 13 67086 189 90561159
Renal vein thrombosis 45.16 11.13 17 67082 592 90560756
Urinary tract infection 45.02 11.13 383 66716 305249 90256099
Haemoptysis 44.85 11.13 85 67014 33235 90528113
Abdominal compartment syndrome 44.42 11.13 18 67081 765 90560583
Haematuria 44.42 11.13 87 67012 34850 90526498
General physical health deterioration 44.38 11.13 126 66973 354989 90206359
HELLP syndrome 42.90 11.13 20 67079 1197 90560151
Lower limb fracture 42.86 11.13 6 67093 85007 90476341
Cerebellar haemorrhage 42.79 11.13 22 67077 1631 90559717
Dry mouth 42.60 11.13 44 67055 184015 90377333
Gait disturbance 42.56 11.13 80 67019 260416 90300932
Ocular retrobulbar haemorrhage 42.56 11.13 11 67088 104 90561244
Wound infection 42.39 11.13 13 67086 106389 90454959
Autoimmune disorder 42.23 11.13 4 67095 76740 90484608
Mixed liver injury 42.04 11.13 39 67060 7584 90553764
Premature rupture of membranes 41.92 11.13 34 67065 5524 90555824
Hip arthroplasty 41.86 11.13 4 67095 76204 90485144
Device related infection 41.37 11.13 71 67028 25715 90535633
Loss of personal independence in daily activities 40.96 11.13 25 67074 136080 90425268
Nasopharyngitis 40.87 11.13 159 66940 406945 90154403
Hypercholesterolaemia 40.79 11.13 12 67087 100880 90460468
Thrombotic microangiopathy 40.46 11.13 54 67045 15689 90545659
Renal failure 40.37 11.13 198 66901 130809 90430539
Hypervolaemia 39.76 11.13 80 67019 32677 90528671
Cardiac valve replacement complication 39.74 11.13 11 67088 138 90561210
Incorrect drug administration rate 39.50 11.13 32 67067 5191 90556157
Spinal subdural haematoma 39.38 11.13 11 67088 143 90561205
Arterial haemorrhage 39.15 11.13 24 67075 2499 90558849
Febrile neutropenia 39.00 11.13 225 66874 158124 90403224
Drug abuse 38.84 11.13 7 67092 82340 90479008
Suicide attempt 38.78 11.13 5 67094 75394 90485954
Tachypnoea 38.65 11.13 62 67037 21247 90540101
Cholestasis 38.63 11.13 84 67015 36215 90525133
Autoimmune heparin-induced thrombocytopenia 37.68 11.13 7 67092 9 90561339
Cardiac septal defect 37.63 11.13 16 67083 769 90560579
Subcapsular renal haematoma 37.35 11.13 13 67086 360 90560988
Platelet aggregation inhibition 37.15 11.13 11 67088 178 90561170
Paraplegia 37.15 11.13 26 67073 3386 90557962
Hyperlactacidaemia 37.03 11.13 28 67071 4108 90557240
Hypoaesthesia 36.72 11.13 115 66984 314095 90247253
Abdominal pain upper 36.63 11.13 125 66974 332549 90228799
Intracranial haematoma 36.46 11.13 13 67086 387 90560961
Truncus arteriosus persistent 36.43 11.13 13 67086 388 90560960
Musculoskeletal pain 36.27 11.13 44 67055 171207 90390141
Anticoagulation drug level above therapeutic 35.96 11.13 21 67078 2001 90559347
Toxoplasmosis 35.66 11.13 20 67079 1765 90559583
Rectosigmoid cancer 35.50 11.13 11 67088 209 90561139
Red blood cell sedimentation rate increased 34.93 11.13 9 67090 82586 90478762
Coronary vascular graft occlusion 34.82 11.13 6 67093 3 90561345
Ventricular tachycardia 34.46 11.13 64 67035 24644 90536704
Metabolic acidosis 34.43 11.13 105 66994 55571 90505777
Adverse drug reaction 34.34 11.13 22 67077 116679 90444669
Liver injury 33.88 11.13 46 67053 170521 90390827
Dry gangrene 33.77 11.13 14 67085 631 90560717
Peritoneal haematoma 33.68 11.13 9 67090 98 90561250
Malaise 33.66 11.13 275 66824 585711 89975637
Phaeochromocytoma crisis 33.54 11.13 12 67087 361 90560987
Tonsillar haemorrhage 33.49 11.13 11 67088 254 90561094
Brain oedema 33.49 11.13 52 67047 17333 90544015
Infection 33.47 11.13 146 66953 361948 90199400
Pulse absent 33.43 11.13 31 67068 6024 90555324
Suicidal ideation 33.31 11.13 7 67092 73848 90487500
Intra-abdominal haemorrhage 33.05 11.13 22 67077 2640 90558708
Calciphylaxis 32.79 11.13 24 67075 3352 90557996
Puncture site haemorrhage 32.78 11.13 12 67087 386 90560962
Muscle spasms 32.47 11.13 88 67011 251795 90309553
Product measured potency issue 32.43 11.13 9 67090 114 90561234
Pelvic haematoma 32.07 11.13 14 67085 718 90560630
Joint stiffness 32.06 11.13 9 67090 78033 90483315
Kidney rupture 31.71 11.13 8 67091 68 90561280
Pre-eclampsia 31.68 11.13 40 67059 11008 90550340
Immune thrombocytopenia 31.66 11.13 44 67055 13282 90548066
Product administration error 31.43 11.13 64 67035 26359 90534989
Ventricular fibrillation 31.34 11.13 45 67054 13999 90547349
Pulmonary haemorrhage 31.30 11.13 34 67065 7979 90553369
Choroidal effusion 31.06 11.13 14 67085 775 90560573
Infusion related reaction 30.61 11.13 182 66917 416598 90144750
Blood creatinine increased 30.35 11.13 152 66947 101234 90460114
Blepharospasm 30.21 11.13 3 67096 55442 90505906
Foetal growth restriction 30.19 11.13 36 67063 9344 90552004
Postpartum haemorrhage 30.19 11.13 20 67079 2381 90558967
Congenital cardiovascular anomaly 30.16 11.13 12 67087 486 90560862
Ventricle rupture 30.02 11.13 7 67092 41 90561307
Amnesia 29.87 11.13 22 67077 108483 90452865
Intra-abdominal haematoma 29.76 11.13 19 67080 2125 90559223
Catheter site pain 29.72 11.13 28 67071 5551 90555797
Haemolysis 29.62 11.13 34 67065 8476 90552872
Renal artery stenosis 29.49 11.13 19 67080 2158 90559190
Transcription medication error 29.44 11.13 10 67089 257 90561091
Hypovolaemic shock 29.29 11.13 31 67068 7063 90554285
Hepatic function abnormal 29.28 11.13 88 67011 46200 90515148
Toxicity to various agents 29.14 11.13 112 66987 287734 90273614
Urticaria 28.96 11.13 126 66973 312608 90248740
Dizziness 28.84 11.13 288 66811 588996 89972352
Frequent bowel movements 28.74 11.13 4 67095 56931 90504417
Hemiparesis 28.72 11.13 69 67030 31750 90529598
Exostosis 28.63 11.13 3 67096 53131 90508217
Premature labour 28.59 11.13 42 67057 13334 90548014
Prosthetic cardiac valve thrombosis 28.46 11.13 7 67092 53 90561295
Right ventricular failure 28.37 11.13 51 67048 19154 90542194
Haemorrhage subcutaneous 28.24 11.13 22 67077 3374 90557974
Anti factor Xa activity decreased 28.11 11.13 5 67094 4 90561344
Stillbirth 28.06 11.13 31 67068 7412 90553936
Allergic reaction to excipient 27.93 11.13 13 67086 775 90560573
Embolic cerebral infarction 27.87 11.13 12 67087 595 90560753
Acute respiratory distress syndrome 27.85 11.13 64 67035 28622 90532726
Pulmonary oedema 27.73 11.13 105 66994 61975 90499373
Vascular graft occlusion 27.64 11.13 9 67090 202 90561146
Intentional product misuse 27.60 11.13 16 67083 89588 90471760
Taste disorder 27.41 11.13 6 67093 61540 90499808
Infusion site pain 27.37 11.13 51 67048 19687 90541661
Splenic haematoma 27.34 11.13 8 67091 124 90561224
Device occlusion 27.24 11.13 34 67065 9248 90552100
International normalised ratio increased 27.19 11.13 87 67012 47229 90514119
Brain death 27.01 11.13 23 67076 3998 90557350
Vasodilatation 26.88 11.13 20 67079 2864 90558484
Renal infarct 26.70 11.13 16 67083 1599 90559749
Factor Xa activity increased 26.67 11.13 5 67094 7 90561341
Cardiac failure 26.57 11.13 155 66944 109341 90452007
Poor venous access 26.51 11.13 50 67049 19477 90541871
Myocardial calcification 26.50 11.13 9 67090 231 90561117
Foot deformity 26.20 11.13 6 67093 59645 90501703
Drug ineffective for unapproved indication 25.97 11.13 108 66991 66536 90494812
Spontaneous haematoma 25.96 11.13 14 67085 1144 90560204
Hepatic haematoma 25.86 11.13 11 67088 529 90560819
Anticoagulation drug level below therapeutic 25.73 11.13 12 67087 719 90560629
Acute respiratory failure 25.66 11.13 80 67019 42838 90518510
Coronary artery dissection 25.57 11.13 13 67086 941 90560407
Gastrooesophageal reflux disease 25.50 11.13 53 67046 166284 90395064
C-reactive protein increased 25.20 11.13 61 67038 181328 90380020
Pericardial effusion 25.19 11.13 72 67027 36761 90524587
Jugular vein thrombosis 25.11 11.13 21 67078 3560 90557788
Type III immune complex mediated reaction 24.95 11.13 10 67089 413 90560935
Cerebral microembolism 24.84 11.13 4 67095 0 90561348
Melaena 24.75 11.13 69 67030 34728 90526620
Fibrin D dimer increased 24.60 11.13 25 67074 5435 90555913
Faeces soft 24.46 11.13 29 67070 7482 90553866
Stress cardiomyopathy 24.41 11.13 39 67060 13316 90548032
Injection site swelling 24.40 11.13 7 67092 59832 90501516
Back injury 24.20 11.13 3 67096 46619 90514729
Coronary artery perforation 24.13 11.13 5 67094 15 90561333
Blood albumin decreased 24.03 11.13 44 67055 16759 90544589
Visual impairment 24.03 11.13 38 67061 132327 90429021
Bradycardia 23.90 11.13 124 66975 83723 90477625
Peritonitis 23.76 11.13 48 67051 19657 90541691
Cerebral venous thrombosis 23.64 11.13 17 67082 2311 90559037
Drug chemical incompatibility 23.60 11.13 7 67092 114 90561234
Premature separation of placenta 23.41 11.13 17 67082 2345 90559003
Ischaemia 23.41 11.13 24 67075 5271 90556077
Blood loss anaemia 23.37 11.13 33 67066 10107 90551241
Cerebral venous sinus thrombosis 23.32 11.13 17 67082 2359 90558989
Lipoedema 23.21 11.13 9 67090 340 90561008
Procedural complication 23.06 11.13 25 67074 5853 90555495
Coagulation factor VIII level increased 22.82 11.13 5 67094 21 90561327
Cerebral amyloid angiopathy 22.77 11.13 8 67091 228 90561120
Gangrene 22.72 11.13 37 67062 12839 90548509
Haemorrhagic stroke 22.69 11.13 26 67073 6470 90554878
Agranulocytosis 22.57 11.13 67 67032 34935 90526413
Eosinophil cationic protein increased 22.48 11.13 6 67093 65 90561283
Circulatory collapse 22.47 11.13 54 67045 24850 90536498
Paratonia 22.45 11.13 5 67094 23 90561325
Coagulation time abnormal 22.31 11.13 6 67093 67 90561281
Abortion induced 22.12 11.13 35 67064 11853 90549495
Spinal cord disorder 22.05 11.13 14 67085 1551 90559797
Pituitary apoplexy 22.03 11.13 7 67092 145 90561203
Lung disorder 21.94 11.13 49 67050 149834 90411514
Page kidney 21.78 11.13 5 67094 27 90561321
Candida infection 21.78 11.13 65 67034 33992 90527356
Blood phosphorus increased 21.73 11.13 21 67078 4297 90557051
Device related sepsis 21.69 11.13 22 67077 4771 90556577
Onychomadesis 21.50 11.13 4 67095 45994 90515354
Cerebral mass effect 21.45 11.13 12 67087 1054 90560294
Rash pustular 21.29 11.13 28 67071 8021 90553327
Pelvic venous thrombosis 21.21 11.13 15 67084 1986 90559362
Capillary fragility test 21.20 11.13 5 67094 31 90561317
Tricuspid valve stenosis 21.18 11.13 4 67095 6 90561342
Haemolytic anaemia 21.16 11.13 34 67065 11663 90549685
Post procedural haematoma 21.16 11.13 13 67086 1359 90559989
Human herpesvirus 6 infection reactivation 21.06 11.13 10 67089 624 90560724
Drug interaction 21.01 11.13 304 66795 276149 90285199
Atrial fibrillation 21.01 11.13 170 66929 133441 90427907
Central venous catheterisation 20.92 11.13 17 67082 2769 90558579
Prescribed underdose 20.92 11.13 15 67084 75004 90486344
Embolic stroke 20.86 11.13 20 67079 4052 90557296
Hypernatraemia 20.83 11.13 30 67069 9357 90551991
Patent ductus arteriosus 20.73 11.13 21 67078 4548 90556800
Congenital clavicular agenesis 20.69 11.13 6 67093 90 90561258
Eschar 20.68 11.13 10 67089 650 90560698
Hydrocephalus 20.63 11.13 24 67075 6070 90555278
Cardio-respiratory arrest 20.57 11.13 97 67002 63043 90498305
Acute pulmonary oedema 20.36 11.13 30 67069 9550 90551798
Tachycardia 20.31 11.13 192 66907 157481 90403867
Purpura 20.26 11.13 38 67061 14740 90546608
Disability 20.25 11.13 3 67096 40742 90520606
Activated partial thromboplastin time shortened 20.19 11.13 9 67090 485 90560863
Apgar score low 20.10 11.13 12 67087 1191 90560157
Protein C decreased 20.09 11.13 5 67094 40 90561308
Urine glucose/creatinine ratio increased 20.07 11.13 7 67092 195 90561153
Staphylococcal infection 20.06 11.13 80 67019 48359 90512989
Clostridium difficile colitis 20.04 11.13 54 67045 26652 90534696
Neurological symptom 19.96 11.13 25 67074 6822 90554526
Facial discomfort 19.92 11.13 8 67091 332 90561016
Mediastinal haemorrhage 19.83 11.13 4 67095 10 90561338
Waterhouse-Friderichsen syndrome 19.83 11.13 4 67095 10 90561338
Anxiety 19.81 11.13 141 66958 309631 90251717
Hypovolaemia 19.64 11.13 34 67065 12397 90548951
Cerebral artery embolism 19.29 11.13 11 67088 1002 90560346
Haemodialysis complication 19.27 11.13 7 67092 220 90561128
Therapeutic product effect increased 19.25 11.13 12 67087 1287 90560061
Disseminated cryptococcosis 19.23 11.13 10 67089 759 90560589
Endocarditis 19.21 11.13 25 67074 7088 90554260
Injection site reaction 19.13 11.13 24 67075 92056 90469292
Cardiac valve vegetation 19.08 11.13 8 67091 371 90560977
Necrosis 19.06 11.13 24 67075 6586 90554762
Heart disease congenital 18.97 11.13 13 67086 1636 90559712
Pseudohypoaldosteronism 18.92 11.13 5 67094 52 90561296
Pseudomonas infection 18.87 11.13 37 67062 14828 90546520
Contusion 18.79 11.13 109 66990 251107 90310241
Cerebrovascular accident 18.79 11.13 156 66943 123377 90437971
Rhinocerebral mucormycosis 18.72 11.13 10 67089 802 90560546
Prescribed overdose 18.71 11.13 27 67072 97598 90463750
Hand dermatitis 18.64 11.13 9 67090 583 90560765
Cerebellar embolism 18.63 11.13 3 67096 0 90561348
Ureteric haemorrhage 18.63 11.13 3 67096 0 90561348
Hand amputation 18.63 11.13 3 67096 0 90561348
Product administered to patient of inappropriate age 18.62 11.13 20 67079 4633 90556715
Organic brain syndrome 18.62 11.13 7 67092 243 90561105
Joint dislocation 18.58 11.13 5 67094 44577 90516771
Suspected transmission of an infectious agent via product 18.57 11.13 8 67091 397 90560951
Ecchymosis 18.55 11.13 33 67066 12290 90549058
Pleural effusion 18.43 11.13 144 66955 111847 90449501
Cerebral reperfusion injury 18.41 11.13 4 67095 16 90561332
Normal newborn 18.30 11.13 48 67051 23314 90538034
Platelet transfusion 18.27 11.13 11 67088 1109 90560239
Cholestatic liver injury 18.24 11.13 18 67081 3779 90557569
Osteoporosis 18.20 11.13 27 67072 96504 90464844
Blood pressure fluctuation 18.18 11.13 8 67091 52405 90508943
Blood creatine increased 18.06 11.13 24 67075 6943 90554405
Ventricular arrhythmia 18.05 11.13 19 67080 4302 90557046
Atrial rupture 18.04 11.13 5 67094 63 90561285
Atheroembolism 18.03 11.13 4 67095 18 90561330
Onychomycosis 18.01 11.13 3 67096 37373 90523975
Left ventricular dysfunction 18.01 11.13 36 67063 14633 90546715
Heavy menstrual bleeding 17.97 11.13 44 67055 20486 90540862
Haemorrhagic cerebral infarction 17.96 11.13 9 67090 632 90560716
Myelomalacia 17.90 11.13 5 67094 65 90561283
Threatened labour 17.77 11.13 10 67089 888 90560460
Pneumothorax 17.77 11.13 42 67057 19125 90542223
Pain in extremity 17.77 11.13 231 66868 450298 90111050
Nervous system disorder 17.56 11.13 45 67054 21548 90539800
Gestational hypertension 17.53 11.13 16 67083 3046 90558302
Epilepsy 17.53 11.13 21 67078 82185 90479163
Haematidrosis 17.49 11.13 5 67094 71 90561277
Product use issue 17.49 11.13 158 66941 329761 90231587
Hepatic infarction 17.38 11.13 9 67090 677 90560671
Arterial intramural haematoma 17.11 11.13 6 67093 170 90561178
Inappropriate schedule of product administration 17.09 11.13 178 66921 149755 90411593
Pruritus 17.09 11.13 290 66809 541235 90020113
Medical device site thrombosis 16.88 11.13 5 67094 81 90561267
Leukocyturia 16.82 11.13 12 67087 1610 90559738
Ischaemic hepatitis 16.79 11.13 15 67084 2778 90558570
Cerebrovascular disorder 16.73 11.13 15 67084 2791 90558557
Haematemesis 16.71 11.13 59 67040 33667 90527681
Uterine haemorrhage 16.56 11.13 19 67080 4733 90556615
Spinal cord oedema 16.48 11.13 6 67093 190 90561158
Recurrence of neuromuscular blockade 16.36 11.13 6 67093 194 90561154
COVID-19 16.30 11.13 194 66905 168649 90392699
Petechiae 16.26 11.13 36 67063 15705 90545643
Infusion site haemorrhage 16.17 11.13 20 67079 5391 90555957
Aneurysm recanalisation 16.09 11.13 3 67096 4 90561344
Protein S decreased 16.07 11.13 4 67095 32 90561316
Catheter placement 16.06 11.13 14 67085 2510 90558838
Extravasation 16.03 11.13 15 67084 2949 90558399
Subdural haemorrhage 16.02 11.13 16 67083 3407 90557941
Splenic haemorrhage 15.91 11.13 6 67093 210 90561138
Air embolism 15.91 11.13 7 67092 366 90560982
Plantar erythema 15.88 11.13 6 67093 211 90561137
Renal haemorrhage 15.83 11.13 10 67089 1098 90560250
Haemarthrosis 15.69 11.13 17 67082 3977 90557371
Femoral nerve palsy 15.69 11.13 3 67096 5 90561343
Haematocrit decreased 15.68 11.13 67 67032 41765 90519583
Aspartate aminotransferase increased 15.66 11.13 130 66969 102807 90458541
Dry eye 15.61 11.13 12 67087 57919 90503429
Decreased appetite 15.61 11.13 191 66908 376349 90184999
Colitis ulcerative 15.60 11.13 13 67086 60253 90501095
Electrocardiogram T wave alternans 15.46 11.13 4 67095 38 90561310
Arm amputation 15.46 11.13 4 67095 38 90561310
Mucosal erosion 15.44 11.13 12 67087 1833 90559515
Renal impairment 15.43 11.13 132 66967 105289 90456059
Platelet toxicity 15.34 11.13 3 67096 6 90561342
Protein S increased 15.34 11.13 3 67096 6 90561342
Renal haematoma 15.30 11.13 6 67093 234 90561114
Drug-device interaction 15.28 11.13 5 67094 114 90561234
Product contamination 15.22 11.13 10 67089 1174 90560174
Peripheral artery occlusion 15.17 11.13 11 67088 1515 90559833
Paralysis 15.10 11.13 29 67070 11449 90549899
Fungal sepsis 15.07 11.13 11 67088 1530 90559818
Bleeding time prolonged 15.05 11.13 8 67091 635 90560713
Vascular parkinsonism 14.96 11.13 5 67094 122 90561226
Gastrointestinal necrosis 14.96 11.13 15 67084 3210 90558138
Leg amputation 14.95 11.13 13 67086 2324 90559024
Diarrhoea 14.92 11.13 557 66542 938633 89622715
Fanconi syndrome 14.90 11.13 12 67087 1931 90559417
Lip erosion 14.81 11.13 10 67089 1228 90560120
Iliac artery occlusion 14.81 11.13 6 67093 255 90561093
Haemoglobin abnormal 14.75 11.13 22 67077 7078 90554270
Heparin-induced thrombocytopenia test 14.74 11.13 3 67096 8 90561340
Dermatitis bullous 14.73 11.13 27 67072 10289 90551059
Injection site pruritus 14.70 11.13 11 67088 53823 90507525
Cerebral artery thrombosis 14.59 11.13 7 67092 447 90560901
Subcapsular hepatic haematoma 14.48 11.13 3 67096 9 90561339
Spinal cord haemorrhage 14.46 11.13 6 67093 271 90561077
Mouth haemorrhage 14.42 11.13 24 67075 8477 90552871
Laryngitis 14.34 11.13 10 67089 50743 90510605
Epidermolysis 14.32 11.13 8 67091 701 90560647
Road traffic accident 14.31 11.13 37 67062 107589 90453759
Antithrombin III deficiency 14.24 11.13 3 67096 10 90561338
Hepatic artery occlusion 14.24 11.13 3 67096 10 90561338
Sinus tachycardia 14.23 11.13 50 67049 28463 90532885
Thrombolysis 14.15 11.13 5 67094 145 90561203
Enterococcal infection 14.08 11.13 26 67073 9965 90551383
Spontaneous haemorrhage 14.07 11.13 8 67091 725 90560623
Accidental exposure to product 13.87 11.13 7 67092 42359 90518989
Chills 13.79 11.13 154 66945 131827 90429521
Hypertension 13.79 11.13 247 66852 457285 90104063
Amniotic cavity infection 13.73 11.13 10 67089 1386 90559962
Alanine aminotransferase increased 13.73 11.13 141 66958 118197 90443151
Peritonitis bacterial 13.69 11.13 18 67081 5153 90556195
Bloody peritoneal effluent 13.67 11.13 4 67095 62 90561286
Fistula discharge 13.63 11.13 9 67090 1066 90560282
Thrombin time abnormal 13.62 11.13 3 67096 13 90561335
Pulmonary artery thrombosis 13.62 11.13 8 67091 771 90560577
Capillary fragility increased 13.62 11.13 3 67096 13 90561335
Vascular stent occlusion 13.61 11.13 4 67095 63 90561285
Pharyngeal haematoma 13.61 11.13 4 67095 63 90561285
Posthaemorrhagic hydrocephalus 13.61 11.13 4 67095 63 90561285
Serratia infection 13.55 11.13 9 67090 1076 90560272
Catheter site swelling 13.42 11.13 11 67088 1814 90559534
Obstructive shock 13.38 11.13 4 67095 67 90561281
Bacterial infection 13.37 11.13 43 67056 23401 90537947
Cardiopulmonary failure 13.36 11.13 16 67083 4172 90557176
Injection site plaque 13.31 11.13 5 67094 173 90561175
Nonreassuring foetal heart rate pattern 13.27 11.13 4 67095 69 90561279
Wound haematoma 13.27 11.13 4 67095 69 90561279
Tonsillar erythema 13.26 11.13 3 67096 15 90561333
Supraventricular tachycardia 13.24 11.13 34 67065 16302 90545046
Medical device site haemorrhage 13.22 11.13 4 67095 70 90561278
Cardiac failure acute 13.14 11.13 28 67071 11901 90549447
Asthenia 13.14 11.13 298 66801 533453 90027895
Vascular device infection 13.11 11.13 28 67071 11924 90549424
Clostridium test positive 13.08 11.13 18 67081 5383 90555965
End stage renal disease 12.97 11.13 23 67076 8548 90552800
Pulmonary hypertension 12.90 11.13 64 67035 42459 90518889
Syndactyly 12.80 11.13 7 67092 588 90560760
Herpes simplex hepatitis 12.77 11.13 7 67092 591 90560757
Unresponsive to stimuli 12.74 11.13 59 67040 38062 90523286
Drug effect less than expected 12.73 11.13 19 67080 6119 90555229
Leukocytosis 12.69 11.13 51 67048 30939 90530409
Electric shock sensation 12.68 11.13 10 67089 1560 90559788
Bronchoalveolar lavage abnormal 12.65 11.13 5 67094 199 90561149
Vascular access complication 12.64 11.13 12 67087 2401 90558947
Intracranial pressure increased 12.60 11.13 20 67079 6791 90554557
Incision site haemorrhage 12.55 11.13 7 67092 611 90560737
Limbal swelling 12.53 11.13 3 67096 20 90561328
Pulse waveform abnormal 12.49 11.13 4 67095 85 90561263
Pyrexia 12.46 11.13 603 66496 659882 89901466
Ankle brachial index decreased 12.45 11.13 4 67095 86 90561262
Normocytic anaemia 12.40 11.13 13 67086 2931 90558417
Catheter site haematoma 12.35 11.13 5 67094 212 90561136
Breast haematoma 12.33 11.13 5 67094 213 90561135
Cardiovascular insufficiency 12.33 11.13 10 67089 1625 90559723
Arterial rupture 12.32 11.13 6 67093 396 90560952
Cyanosis 12.31 11.13 37 67062 19418 90541930
Cytomegalovirus viraemia 12.31 11.13 21 67078 7565 90553783
Anti factor X activity increased 12.28 11.13 3 67096 22 90561326
Angiogram 12.28 11.13 4 67095 90 90561258
Infusion site extravasation 12.26 11.13 25 67074 10303 90551045
Injection site erythema 12.25 11.13 35 67064 98467 90462881
Hypoprothrombinaemia 12.14 11.13 6 67093 409 90560939
Protein S deficiency 11.95 11.13 3 67096 25 90561323
Toxic skin eruption 11.94 11.13 32 67067 15742 90545606
Tracheal haemorrhage 11.92 11.13 5 67094 232 90561116
COVID-19 pneumonia 11.91 11.13 35 67064 18142 90543206
Bacteraemia 11.91 11.13 40 67059 22260 90539088
Gastric ulcer 11.91 11.13 46 67053 27402 90533946
Sinus arrest 11.87 11.13 11 67088 2135 90559213
Stoma site haemorrhage 11.85 11.13 9 67090 1329 90560019
Carotid intima-media thickness increased 11.80 11.13 4 67095 102 90561246
Weight decreased 11.79 11.13 204 66895 379706 90181642
Peripheral embolism 11.72 11.13 9 67090 1351 90559997
Portal vein thrombosis 11.71 11.13 13 67086 3125 90558223
Graft thrombosis 11.71 11.13 5 67094 243 90561105
Balance disorder 11.70 11.13 35 67064 97045 90464303
Foetal exposure timing unspecified 11.69 11.13 6 67093 443 90560905
Endotracheal intubation complication 11.67 11.13 6 67093 445 90560903
Hypofibrinogenaemia 11.66 11.13 9 67090 1361 90559987
Umbilical cord vascular disorder 11.66 11.13 4 67095 106 90561242
Abortion early 11.64 11.13 3 67096 28 90561320
Vulval haemorrhage 11.64 11.13 3 67096 28 90561320
Reticulocytosis 11.61 11.13 5 67094 248 90561100
Immunodeficiency 11.59 11.13 9 67090 43225 90518123
Sinus node dysfunction 11.58 11.13 17 67082 5395 90555953
Seizure like phenomena 11.55 11.13 9 67090 1381 90559967
Hyperphosphataemia 11.55 11.13 14 67085 3697 90557651
Diabetes insipidus 11.46 11.13 13 67086 3199 90558149
Cytokine release syndrome 11.42 11.13 46 67053 27927 90533421
Out of specification test results 11.42 11.13 4 67095 113 90561235
Blood blister 11.41 11.13 11 67088 2244 90559104
Central venous catheter removal 11.40 11.13 6 67093 467 90560881
Cerebral artery occlusion 11.37 11.13 8 67091 1051 90560297
Underdose 11.30 11.13 14 67085 54003 90507345
Vascular malformation 11.28 11.13 7 67092 745 90560603
Adrenomegaly 11.25 11.13 4 67095 118 90561230
Sleep disorder therapy 11.24 11.13 6 67093 480 90560868
Catheter site related reaction 11.22 11.13 8 67091 1073 90560275
Infusion site swelling 11.21 11.13 26 67073 11694 90549654
Seasonal allergy 11.21 11.13 40 67059 22943 90538405
Basal ganglia haemorrhage 11.20 11.13 7 67092 754 90560594
Subdural haematoma evacuation 11.20 11.13 3 67096 33 90561315
Hepatic cytolysis 11.19 11.13 49 67050 30867 90530481
Haemorrhagic cyst 11.16 11.13 5 67094 273 90561075
Intestinal ischaemia 11.14 11.13 22 67077 8861 90552487

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heparin-induced thrombocytopenia 4537.73 11.85 1221 70606 5376 42544132
Vascular stent thrombosis 440.81 11.85 176 71651 3066 42546442
Cardiogenic shock 287.69 11.85 327 71500 35313 42514195
Appendicolith 267.05 11.85 204 71623 13252 42536256
Thrombocytopenia 259.20 11.85 806 71021 189473 42360035
Multiple organ dysfunction syndrome 258.87 11.85 531 71296 96504 42453004
Haematoma 258.86 11.85 276 71551 27747 42521761
Thrombosis 252.87 11.85 431 71396 68080 42481428
Haemorrhage 243.57 11.85 396 71431 60167 42489341
Ventricular fibrillation 242.44 11.85 276 71551 29847 42519661
Appendicitis 222.90 11.85 221 71606 20392 42529116
Heparin resistance 214.79 11.85 51 71776 115 42549393
Labelled drug-drug interaction medication error 210.48 11.85 189 71638 15393 42534115
Pulmonary embolism 199.47 11.85 545 71282 119067 42430441
Shock haemorrhagic 197.97 11.85 186 71641 16056 42533452
Post procedural haemorrhage 197.69 11.85 147 71680 9165 42540343
Activated partial thromboplastin time prolonged 195.53 11.85 183 71644 15720 42533788
Haemorrhage intracranial 163.47 11.85 172 71655 17020 42532488
Retroperitoneal haematoma 161.45 11.85 86 71741 2965 42546543
Cerebral haemorrhage 160.96 11.85 258 71569 38708 42510800
Fatigue 155.56 11.85 313 71514 435328 42114180
Cardiac tamponade 151.86 11.85 109 71718 6431 42543077
Thrombosis in device 147.92 11.85 82 71745 3064 42546444
Blood phosphorus increased 146.09 11.85 140 71687 12385 42537123
Arterial thrombosis 135.03 11.85 64 71763 1712 42547796
Arthralgia 132.49 11.85 92 71735 205146 42344362
Toxicity to various agents 131.15 11.85 116 71711 229020 42320488
Drug abuse 127.26 11.85 14 71813 104757 42444751
Low birth weight baby 125.14 11.85 116 71711 9839 42539669
Haematoma muscle 120.56 11.85 63 71764 2087 42547421
Myasthenia gravis 118.33 11.85 141 71686 15996 42533512
Sepsis 111.71 11.85 644 71183 198690 42350818
Coagulation time shortened 111.32 11.85 32 71795 186 42549322
Retroperitoneal haemorrhage 110.65 11.85 68 71759 3087 42546421
Depression 110.46 11.85 26 71801 111337 42438171
Autoimmune heparin-induced thrombocytopenia 106.57 11.85 23 71804 26 42549482
Premature baby 106.32 11.85 161 71666 22992 42526516
Stress 102.80 11.85 229 71598 43983 42505525
Hyperphosphataemia 102.64 11.85 118 71709 12886 42536622
Intraventricular haemorrhage 100.09 11.85 69 71758 3815 42545693
Diarrhoea 98.73 11.85 421 71406 460428 42089080
Adrenal haemorrhage 98.05 11.85 32 71795 300 42549208
Analgesic therapy 93.79 11.85 82 71745 6442 42543066
Subarachnoid haemorrhage 92.48 11.85 118 71709 14354 42535154
Coagulation time prolonged 92.02 11.85 46 71781 1386 42548122
Death 89.91 11.85 449 71378 470736 42078772
Intra-abdominal haemorrhage 89.88 11.85 58 71769 2870 42546638
Cardiac ventricular thrombosis 89.81 11.85 49 71778 1773 42547735
Weight decreased 88.92 11.85 133 71694 207815 42341693
Compartment syndrome 88.48 11.85 60 71767 3229 42546279
Deep vein thrombosis 88.32 11.85 308 71519 76649 42472859
Drug reaction with eosinophilia and systemic symptoms 87.96 11.85 209 71618 41866 42507642
Heparin-induced thrombocytopenia test positive 85.71 11.85 23 71804 99 42549409
Ascites 85.26 11.85 249 71578 56429 42493079
Sleep disorder therapy 84.08 11.85 79 71748 6815 42542693
Drug therapy 83.41 11.85 76 71751 6304 42543204
Muscle haemorrhage 82.84 11.85 63 71764 4062 42545446
Septic shock 77.46 11.85 333 71494 91339 42458169
Abdominal distension 77.08 11.85 281 71546 71454 42478054
Brain herniation 76.22 11.85 64 71763 4759 42544749
Pericardial haemorrhage 74.98 11.85 56 71771 3513 42545995
Joint swelling 73.41 11.85 13 71814 68009 42481499
Coagulation time abnormal 73.10 11.85 20 71807 94 42549414
Decreased appetite 72.82 11.85 134 71693 193003 42356505
Eosinophilia 72.67 11.85 167 71660 32732 42516776
Disseminated intravascular coagulation 72.34 11.85 141 71686 24653 42524855
Catheter site haemorrhage 72.18 11.85 48 71779 2500 42547008
Dizziness 71.98 11.85 200 71627 249054 42300454
Antacid therapy 71.27 11.85 61 71766 4656 42544852
Hypophosphataemia 70.96 11.85 127 71700 20818 42528690
Haemodynamic instability 70.37 11.85 96 71731 12461 42537047
Coagulation time 70.04 11.85 13 71814 0 42549508
Blood uric acid increased 69.80 11.85 107 71720 15440 42534068
Haemothorax 67.72 11.85 62 71765 5174 42544334
Drug hypersensitivity 67.71 11.85 339 71488 99050 42450458
Procedural haemorrhage 67.45 11.85 48 71779 2793 42546715
Venous thrombosis 66.79 11.85 55 71772 3980 42545528
Atrial thrombosis 66.73 11.85 45 71782 2399 42547109
Incorrect route of product administration 65.84 11.85 134 71693 24171 42525337
Iron deficiency 65.70 11.85 87 71740 10974 42538534
Fall 65.62 11.85 191 71636 234329 42315179
Cardiac arrest 64.95 11.85 359 71468 108961 42440547
Coagulopathy 63.41 11.85 125 71702 22037 42527471
Muscle spasms 63.24 11.85 33 71794 86011 42463497
Bacterial infection 63.22 11.85 143 71684 27736 42521772
Vascular stent occlusion 62.61 11.85 21 71806 216 42549292
Intentional overdose 62.14 11.85 7 71820 51449 42498059
Pulmonary haemorrhage 60.67 11.85 85 71742 11312 42538196
Psoriasis 60.27 11.85 6 71821 48598 42500910
Coronary artery thrombosis 59.82 11.85 41 71786 2245 42547263
Malaise 59.18 11.85 173 71654 211983 42337525
Injection site pain 58.27 11.85 13 71814 57785 42491723
Myalgia 56.87 11.85 47 71780 96033 42453475
Peripheral ischaemia 56.56 11.85 62 71765 6423 42543085
Rheumatoid arthritis 56.02 11.85 4 71823 42436 42507072
Peripheral artery thrombosis 55.95 11.85 42 71785 2655 42546853
Skin necrosis 54.44 11.85 60 71767 6254 42543254
Cerebral venous sinus thrombosis 53.86 11.85 26 71801 725 42548783
Coagulation test abnormal 53.78 11.85 25 71802 639 42548869
Drug ineffective 53.65 11.85 1414 70413 628783 41920725
Aortic thrombosis 53.36 11.85 29 71798 1041 42548467
Loss of personal independence in daily activities 52.71 11.85 10 71817 49806 42499702
Haemoglobin decreased 52.70 11.85 393 71434 132078 42417430
Pain 52.65 11.85 223 71604 244625 42304883
Heparin-induced thrombocytopenia test 52.32 11.85 17 71810 157 42549351
Pharyngeal haemorrhage 52.17 11.85 26 71801 778 42548730
Spinal epidural haematoma 50.57 11.85 21 71806 406 42549102
Rash 50.33 11.85 268 71559 276686 42272822
Suspected product quality issue 50.01 11.85 18 71809 232 42549276
Arterial haemorrhage 49.61 11.85 29 71798 1200 42548308
Abdominal discomfort 49.46 11.85 33 71794 75222 42474286
Subdural haematoma 48.41 11.85 115 71712 23023 42526485
Gastrointestinal haemorrhage 47.78 11.85 305 71522 97421 42452087
Pulmonary haematoma 46.86 11.85 13 71814 65 42549443
Blood cholesterol increased 46.62 11.85 124 71703 26617 42522891
Dehydration 46.08 11.85 107 71720 141660 42407848
Neuralgia 45.80 11.85 120 71707 25527 42523981
Neuropathy peripheral 45.58 11.85 63 71764 101790 42447718
Memory impairment 45.48 11.85 14 71813 50208 42499300
Mediastinal haematoma 45.08 11.85 14 71813 110 42549398
Asthenia 44.97 11.85 283 71544 280510 42268998
Blood calcium increased 44.92 11.85 63 71764 8391 42541117
Malignant neoplasm progression 43.73 11.85 72 71755 108328 42441180
Product measured potency issue 43.41 11.85 13 71814 89 42549419
Cerebral infarction 43.13 11.85 133 71694 31036 42518472
Aggression 42.42 11.85 11 71816 44152 42505356
Pulseless electrical activity 42.07 11.85 61 71766 8376 42541132
Product quality issue 41.97 11.85 93 71734 17789 42531719
Balance disorder 41.87 11.85 14 71813 47631 42501877
Rash maculo-papular 41.18 11.85 148 71679 37355 42512153
Increased viscosity of upper respiratory secretion 40.41 11.85 17 71810 340 42549168
Acute respiratory distress syndrome 40.30 11.85 127 71700 29981 42519527
Cerebral mass effect 39.90 11.85 26 71801 1308 42548200
Arthritis 39.42 11.85 11 71816 42054 42507454
Therapeutic product effect decreased 39.23 11.85 150 71677 39000 42510508
End stage renal disease 38.73 11.85 86 71741 16472 42533036
Vascular access site haemorrhage 38.63 11.85 9 71818 18 42549490
Renal infarct 38.34 11.85 29 71798 1854 42547654
Total lung capacity decreased 38.06 11.85 38 71789 3532 42545976
Intracardiac thrombus 37.87 11.85 32 71795 2400 42547108
Product use in unapproved indication 37.87 11.85 476 71351 183980 42365528
Gait disturbance 37.77 11.85 67 71760 97933 42451575
Embolism 37.50 11.85 59 71768 8704 42540804
Coronary artery perforation 37.42 11.85 11 71816 70 42549438
Insomnia 37.03 11.85 91 71736 118162 42431346
Anaemia 36.48 11.85 669 71158 279609 42269899
Cerebral haematoma 36.24 11.85 46 71781 5564 42543944
Bacteroides infection 36.15 11.85 32 71795 2555 42546953
Hyponatraemia 35.90 11.85 293 71534 101169 42448339
Incision site pain 35.88 11.85 28 71799 1875 42547633
Obstructive shock 35.88 11.85 10 71817 51 42549457
Dysgeusia 35.88 11.85 7 71820 34182 42515326
Choroidal infarction 35.69 11.85 11 71816 84 42549424
Ventricular tachycardia 35.69 11.85 122 71705 30038 42519470
Off label use 35.68 11.85 1362 70465 636973 41912535
Disease progression 35.23 11.85 124 71703 143532 42405976
Confusional state 35.15 11.85 154 71673 167443 42382065
Product administration error 35.00 11.85 88 71739 18255 42531253
Troponin increased 34.87 11.85 90 71737 18972 42530536
Vascular pseudoaneurysm 34.85 11.85 32 71795 2680 42546828
Aortic stenosis 34.85 11.85 57 71770 8688 42540820
Ulcer 34.70 11.85 82 71745 16359 42533149
Prostate cancer 34.49 11.85 16 71811 44627 42504881
Haematuria 34.41 11.85 190 71637 57609 42491899
Pain in extremity 34.32 11.85 134 71693 150470 42399038
Puncture site haemorrhage 34.13 11.85 15 71812 335 42549173
Foetal exposure during pregnancy 34.06 11.85 164 71663 47147 42502361
Weight increased 33.89 11.85 83 71744 107900 42441608
Serratia sepsis 33.82 11.85 12 71815 148 42549360
Hypotension 33.53 11.85 615 71212 257016 42292492
Acute myocardial infarction 33.17 11.85 189 71638 57976 42491532
Anticoagulation drug level below therapeutic 33.17 11.85 21 71806 1005 42548503
Pruritus 32.96 11.85 185 71642 188586 42360922
Hypercoagulation 32.85 11.85 24 71803 1455 42548053
Chest wall haematoma 32.62 11.85 13 71814 225 42549283
Therapeutic product effect incomplete 32.62 11.85 43 71784 70896 42478612
Peripheral artery occlusion 32.57 11.85 26 71801 1800 42547708
Kounis syndrome 32.55 11.85 34 71793 3334 42546174
Feeling abnormal 32.40 11.85 42 71785 69744 42479764
Anti factor V antibody 32.35 11.85 14 71813 301 42549207
Blood urea increased 31.51 11.85 124 71703 32669 42516839
Dry mouth 31.47 11.85 142 71685 39737 42509771
Cerebral hyperperfusion syndrome 31.40 11.85 10 71817 86 42549422
Anxiety 31.35 11.85 99 71728 118461 42431047
Prosthetic cardiac valve thrombosis 31.34 11.85 8 71819 27 42549481
Arthropathy 31.18 11.85 6 71821 29591 42519917
Haemorrhagic infarction 31.18 11.85 16 71811 510 42548998
Acute kidney injury 31.00 11.85 824 71003 366513 42182995
Haemorrhagic transformation stroke 30.88 11.85 25 71802 1766 42547742
Swelling 30.42 11.85 177 71650 54708 42494800
Blood loss anaemia 30.40 11.85 57 71770 9679 42539829
Vertigo 30.34 11.85 10 71817 34337 42515171
Intrapericardial thrombosis 30.26 11.85 9 71818 60 42549448
Bronchopulmonary aspergillosis allergic 30.18 11.85 38 71789 4560 42544948
Subcapsular renal haematoma 29.97 11.85 16 71811 554 42548954
Congenital hiatus hernia 29.86 11.85 44 71783 6130 42543378
Melaena 29.86 11.85 137 71690 38609 42510899
Diabetes insipidus 29.81 11.85 34 71793 3679 42545829
Jugular vein thrombosis 29.67 11.85 26 71801 2048 42547460
Vena cava thrombosis 29.50 11.85 23 71804 1538 42547970
Tongue haematoma 29.29 11.85 10 71817 109 42549399
Gastroduodenal ulcer 29.20 11.85 17 71810 698 42548810
Cerebral palsy 29.18 11.85 14 71813 385 42549123
Serratia infection 29.11 11.85 21 71806 1248 42548260
Primary adrenal insufficiency 29.07 11.85 13 71814 303 42549205
Abdominal wall haematoma 29.07 11.85 27 71800 2295 42547213
Acute generalised exanthematous pustulosis 28.96 11.85 52 71775 8543 42540965
Device related thrombosis 28.86 11.85 22 71805 1423 42548085
Nightmare 28.74 11.85 4 71823 25008 42524500
Cardiac procedure complication 28.69 11.85 11 71816 171 42549337
Alopecia 28.68 11.85 7 71820 29269 42520239
Psychotic disorder 28.58 11.85 7 71820 29201 42520307
Hospitalisation 28.47 11.85 51 71776 74279 42475229
Anticoagulation drug level above therapeutic 28.41 11.85 28 71799 2562 42546946
Hereditary angioedema 28.38 11.85 22 71805 1459 42548049
Electrocardiogram ST segment elevation 28.25 11.85 42 71785 5897 42543611
Vascular access site haematoma 28.18 11.85 6 71821 6 42549502
Dry skin 28.15 11.85 24 71803 48314 42501194
Intestinal ischaemia 28.12 11.85 54 71773 9334 42540174
Extradural haematoma 27.94 11.85 21 71806 1330 42548178
Burkholderia test positive 27.87 11.85 19 71808 1031 42548477
Upper gastrointestinal haemorrhage 27.85 11.85 113 71714 30186 42519322
Peripheral swelling 27.84 11.85 70 71757 90200 42459308
Reperfusion injury 27.80 11.85 9 71818 82 42549426
Haemoperitoneum 27.77 11.85 25 71802 2041 42547467
Paraesthesia 27.61 11.85 51 71776 73408 42476100
Congenital multiplex arthrogryposis 27.60 11.85 12 71815 261 42549247
Embolic stroke 27.43 11.85 38 71789 5002 42544506
Cerebral reperfusion injury 27.26 11.85 6 71821 8 42549500
Bronchial haemorrhage 26.81 11.85 16 71811 688 42548820
Cognitive disorder 26.78 11.85 12 71815 34160 42515348
Haemorrhagic cholecystitis 26.78 11.85 10 71817 144 42549364
Leukocytosis 26.68 11.85 110 71717 29598 42519910
Lymphocyte count decreased 26.59 11.85 105 71722 27704 42521804
Abnormal behaviour 26.55 11.85 6 71821 26445 42523063
Product dose omission issue 26.01 11.85 153 71674 154212 42395296
Pulmonary artery thrombosis 25.92 11.85 17 71810 865 42548643
Poor venous access 25.89 11.85 45 71782 7207 42542301
Brain oedema 25.76 11.85 73 71754 16254 42533254
Blood creatinine increased 25.67 11.85 291 71536 109712 42439796
Vascular graft thrombosis 25.64 11.85 10 71817 163 42549345
Osteoarthritis 25.60 11.85 5 71822 24400 42525108
Herpes zoster 25.60 11.85 17 71810 38860 42510648
Toxic epidermal necrolysis 25.58 11.85 101 71726 26649 42522859
Respiratory failure 25.56 11.85 329 71498 127803 42421705
Shock 25.50 11.85 107 71720 29014 42520494
Red blood cells urine positive 25.45 11.85 23 71804 1887 42547621
Spinal cord haematoma 25.29 11.85 9 71818 112 42549396
Haemorrhagic stroke 25.22 11.85 45 71782 7357 42542151
Therapeutic product effect increased 25.17 11.85 16 71811 771 42548737
Overdose 25.04 11.85 92 71735 105172 42444336
Wrong technique in product usage process 25.04 11.85 21 71806 42614 42506894
Haemarthrosis 24.60 11.85 32 71795 3966 42545542
Lung opacity 24.56 11.85 39 71788 5798 42543710
Vasodilatation 24.54 11.85 19 71808 1258 42548250
Visual impairment 24.39 11.85 22 71805 43091 42506417
Accidental exposure to product 24.06 11.85 3 71824 20390 42529118
Acute right ventricular failure 24.01 11.85 9 71818 131 42549377
Blood aldosterone decreased 24.01 11.85 5 71822 4 42549504
Graft thrombosis 23.67 11.85 11 71816 281 42549227
Blood test abnormal 23.67 11.85 61 71766 12845 42536663
Aneurysm ruptured 23.55 11.85 14 71813 598 42548910
Blood pressure fluctuation 23.48 11.85 8 71819 26900 42522608
Sedation 23.42 11.85 11 71816 30464 42519044
Haemorrhagic cerebral infarction 23.36 11.85 16 71811 875 42548633
Acute respiratory failure 23.30 11.85 128 71699 38730 42510778
Frequent bowel movements 23.29 11.85 4 71823 21403 42528105
Vision blurred 23.23 11.85 34 71793 53665 42495843
Premature delivery 23.18 11.85 9 71818 145 42549363
Basal cell carcinoma 23.14 11.85 5 71822 22728 42526780
Agitation 22.99 11.85 46 71781 64268 42485240
Intra-abdominal haematoma 22.98 11.85 20 71807 1561 42547947
Ischaemic stroke 22.94 11.85 86 71741 22147 42527361
Bullous haemorrhagic dermatosis 22.82 11.85 8 71819 95 42549413
Pleuritic pain 22.81 11.85 42 71785 7035 42542473
Aortic dissection 22.77 11.85 27 71800 3045 42546463
Hypoaldosteronism 22.65 11.85 11 71816 311 42549197
Thrombectomy 22.59 11.85 8 71819 98 42549410
Hot flush 22.58 11.85 5 71822 22346 42527162
Epistaxis 22.56 11.85 191 71636 66635 42482873
Ocular ischaemic syndrome 22.51 11.85 6 71821 25 42549483
Hallucination 22.44 11.85 39 71788 57468 42492040
Iliac artery occlusion 22.42 11.85 9 71818 159 42549349
Nasopharyngitis 22.30 11.85 70 71757 83926 42465582
Gastrointestinal necrosis 22.28 11.85 31 71796 4097 42545411
Infusion site extravasation 22.21 11.85 36 71791 5445 42544063
Aplastic anaemia 22.16 11.85 58 71769 12326 42537182
Medical device site thrombosis 21.97 11.85 6 71821 28 42549480
Pancreatic haemorrhage 21.97 11.85 6 71821 28 42549480
Enterococcus test positive 21.88 11.85 20 71807 1665 42547843
Platelet transfusion 21.79 11.85 20 71807 1674 42547834
Syncope 21.65 11.85 90 71737 99316 42450192
Immune thrombocytopenia 21.60 11.85 54 71773 11162 42538346
Myelosuppression 21.32 11.85 22 71805 40439 42509069
Adverse drug reaction 21.30 11.85 19 71808 37415 42512093
Intestinal infarction 21.13 11.85 13 71814 591 42548917
Activated partial thromboplastin time shortened 20.90 11.85 12 71815 480 42549028
Erectile dysfunction 20.73 11.85 8 71819 24905 42524603
Antiphospholipid syndrome 20.69 11.85 13 71814 614 42548894
Cataract 20.67 11.85 13 71814 30591 42518917
Conductive deafness 20.35 11.85 12 71815 505 42549003
Irritability 20.34 11.85 11 71816 28117 42521391
Hypovolaemic shock 20.28 11.85 45 71782 8614 42540894
Palpitations 20.23 11.85 34 71793 50763 42498745
Haemoptysis 20.08 11.85 140 71687 46027 42503481
Dyspnoea 19.94 11.85 581 71246 442040 42107468
White blood cell count decreased 19.90 11.85 107 71720 110289 42439219
Nervous system disorder 19.85 11.85 69 71758 17126 42532382
Haemostasis 19.79 11.85 8 71819 144 42549364
Gastric haemorrhage 19.59 11.85 50 71777 10465 42539043
Hyperlipidaemia 19.58 11.85 80 71747 21436 42528072
Dyspnoea exertional 19.57 11.85 34 71793 50114 42499394
Product contamination 19.55 11.85 15 71812 980 42548528
Venous thrombosis limb 19.54 11.85 22 71805 2347 42547161
Drug effect less than expected 19.40 11.85 28 71799 3829 42545679
Ischaemic hepatitis 19.31 11.85 21 71806 2156 42547352
Rash morbilliform 19.23 11.85 29 71798 4124 42545384
Myocardial haemorrhage 19.22 11.85 6 71821 48 42549460
Aspiration 19.13 11.85 70 71757 17816 42531692
Splenic infarction 19.08 11.85 22 71805 2409 42547099
Liver function test increased 18.71 11.85 75 71752 19923 42529585
Hypothyroidism 18.60 11.85 16 71811 32068 42517440
Tinnitus 18.59 11.85 13 71814 28925 42520583
Skin ulcer 18.53 11.85 10 71817 25591 42523917
Unresponsive to stimuli 18.53 11.85 103 71724 31300 42518208
Incision site haematoma 18.42 11.85 7 71820 106 42549402
Hepatic infarction 18.32 11.85 9 71818 261 42549247
Abdominal pain 18.29 11.85 435 71392 190036 42359472
Back pain 18.23 11.85 152 71675 141624 42407884
Brain death 18.23 11.85 24 71803 3010 42546498
Fasciotomy 18.04 11.85 6 71821 60 42549448
Amnesia 17.97 11.85 13 71814 28424 42521084
Asthma 17.93 11.85 50 71777 62264 42487244
Coronary artery aneurysm 17.79 11.85 7 71820 117 42549391
Respiratory distress 17.70 11.85 126 71701 41694 42507814
Foetal exposure timing unspecified 17.65 11.85 9 71818 283 42549225
Peliosis hepatis 17.61 11.85 6 71821 65 42549443
Transfusion 17.56 11.85 48 71779 10466 42539042
Bronchopulmonary aspergillosis 17.49 11.85 72 71755 19357 42530151
Oral mucosal eruption 17.48 11.85 10 71817 397 42549111
Ventricular extrasystoles 17.47 11.85 56 71771 13334 42536174
Cough 17.44 11.85 204 71623 177899 42371609
Blood pressure systolic increased 17.40 11.85 13 71814 27955 42521553
Hypertransaminasaemia 17.32 11.85 44 71783 9183 42540325
Nephrolithiasis 17.26 11.85 22 71805 36808 42512700
Post procedural pulmonary embolism 17.26 11.85 5 71822 30 42549478
Foetal megacystis 17.21 11.85 6 71821 70 42549438
Blood pressure increased 17.17 11.85 101 71726 101827 42447681
Interstitial lung disease 17.10 11.85 71 71756 78391 42471117
Respiratory tract oedema 17.08 11.85 10 71817 415 42549093
Oesophageal injury 16.98 11.85 8 71819 211 42549297
Orthostatic hypotension 16.82 11.85 16 71811 30554 42518954
Livedo reticularis 16.81 11.85 22 71805 2742 42546766
Foetal growth restriction 16.58 11.85 31 71796 5252 42544256
Flatulence 16.56 11.85 11 71816 25141 42524367
Diplegia 16.43 11.85 15 71812 1247 42548261
Vascular graft occlusion 16.35 11.85 11 71816 584 42548924
Hemiplegia 16.30 11.85 39 71788 7840 42541668
Myelodysplastic syndrome 16.30 11.85 9 71818 22736 42526772
Blindness 16.29 11.85 5 71822 17973 42531535
Drug withdrawal syndrome 16.22 11.85 8 71819 21541 42527967
Subcutaneous haematoma 16.22 11.85 14 71813 1081 42548427
Spontaneous heparin-induced thrombocytopenia syndrome 16.16 11.85 3 71824 0 42549508
Cardiovascular deconditioning 16.16 11.85 3 71824 0 42549508
Anisochromia 16.16 11.85 3 71824 0 42549508
Acquired antithrombin III deficiency 16.16 11.85 3 71824 0 42549508
Road traffic accident 16.10 11.85 6 71821 19087 42530421
Incorrect drug administration rate 16.04 11.85 19 71808 2141 42547367
Hypoaesthesia 15.99 11.85 64 71763 71399 42478109
Cardiac disorder 15.82 11.85 37 71790 48895 42500613
Renal cyst ruptured 15.81 11.85 5 71822 42 42549466
Hyperkalaemia 15.78 11.85 206 71621 80252 42469256
Suspected transmission of an infectious agent via product 15.78 11.85 13 71814 941 42548567
Visual acuity reduced 15.69 11.85 5 71822 17545 42531963
Hallucination, auditory 15.69 11.85 3 71824 14861 42534647
Delusion 15.49 11.85 3 71824 14731 42534777
Encephalopathy 15.49 11.85 121 71706 41212 42508296
Abdominal pain upper 15.48 11.85 79 71748 82530 42466978
Splenic haematoma 15.43 11.85 7 71820 169 42549339
Eczema 15.32 11.85 21 71806 34065 42515443
Hepatic artery thrombosis 15.28 11.85 8 71819 266 42549242
Mean cell haemoglobin concentration 15.21 11.85 5 71822 48 42549460
Treatment noncompliance 15.20 11.85 25 71802 37647 42511861
Mouth haemorrhage 15.18 11.85 33 71794 6228 42543280
Urea renal clearance decreased 15.14 11.85 4 71823 16 42549492
Bleeding time prolonged 15.05 11.85 11 71816 667 42548841
Device related sepsis 15.04 11.85 25 71802 3862 42545646
Pulmonary alveolar haemorrhage 15.03 11.85 57 71770 14759 42534749
Bladder cancer 14.99 11.85 5 71822 17042 42532466
Heart rate decreased 14.97 11.85 24 71803 36508 42513000
Nutritional condition abnormal 14.95 11.85 10 71817 526 42548982
Coronary ostial stenosis 14.94 11.85 6 71821 106 42549402
Full blood count decreased 14.93 11.85 8 71819 20552 42528956
Injection site swelling 14.89 11.85 5 71822 16968 42532540
Bone pain 14.87 11.85 11 71816 23781 42525727
Lumbar puncture 14.84 11.85 6 71821 108 42549400
Sleep apnoea syndrome 14.84 11.85 9 71818 21599 42527909
Nephritis allergic 14.80 11.85 11 71816 685 42548823
Implant site haematoma 14.74 11.85 6 71821 110 42549398
Hydrocephalus 14.70 11.85 32 71795 6046 42543462
Neuroleptic malignant syndrome 14.67 11.85 9 71818 21463 42528045
Mental disorder 14.65 11.85 6 71821 18023 42531485
Procedural pain 14.64 11.85 31 71796 5748 42543760
Ventricular asystole 14.60 11.85 8 71819 292 42549216
Spontaneous haemorrhage 14.60 11.85 10 71817 547 42548961
Gout 14.59 11.85 89 71738 27966 42521542
Paranoia 14.45 11.85 3 71824 14023 42535485
Osteonecrosis of jaw 14.45 11.85 7 71820 19042 42530466
Alveolitis necrotising 14.42 11.85 4 71823 20 42549488
Depressed mood 14.38 11.85 11 71816 23373 42526135
Coronary artery dissection 14.21 11.85 8 71819 308 42549200
Intentional self-injury 14.19 11.85 4 71823 15198 42534310
Hepatic haematoma 14.17 11.85 9 71818 433 42549075
Femoral nerve palsy 14.14 11.85 5 71822 61 42549447
Jugular vein occlusion 14.09 11.85 3 71824 3 42549505
Colitis ulcerative 14.05 11.85 14 71813 26161 42523347
Neutropenia 14.02 11.85 244 71583 199187 42350321
Product prescribing error 13.98 11.85 14 71813 26098 42523410
Neoplasm progression 13.93 11.85 17 71810 28983 42520525
Laboratory test abnormal 13.89 11.85 11 71816 22967 42526541
Transaminases increased 13.87 11.85 99 71728 32786 42516722
Ischaemia 13.87 11.85 28 71799 5019 42544489
Hypergastrinaemia 13.76 11.85 7 71820 219 42549289
Myocardial infarction 13.75 11.85 138 71689 123871 42425637
Fluid retention 13.70 11.85 20 71807 31599 42517909
Device related infection 13.66 11.85 69 71758 20210 42529298
Lymphadenopathy 13.59 11.85 22 71805 33343 42516165
Withdrawal syndrome 13.59 11.85 4 71823 14771 42534737
Gangrene 13.57 11.85 28 71799 5098 42544410
Neonatal respiratory distress syndrome 13.57 11.85 26 71801 4487 42545021
Palmar-plantar erythrodysaesthesia syndrome 13.55 11.85 9 71818 20573 42528935
Thrombotic microangiopathy 13.48 11.85 55 71772 14727 42534781
Staphylococcus test positive 13.30 11.85 23 71804 3669 42545839
Renal haemorrhage 13.29 11.85 15 71812 1604 42547904
Apgar score abnormal 13.28 11.85 4 71823 28 42549480
Prostatic specific antigen increased 13.17 11.85 6 71821 16919 42532589
Protein C decreased 13.16 11.85 4 71823 29 42549479
Splenic rupture 13.08 11.85 15 71812 1632 42547876
Drug ineffective for unapproved indication 13.06 11.85 127 71700 46036 42503472
Retinal pigment epitheliopathy 13.04 11.85 7 71820 245 42549263
Food interaction 13.02 11.85 12 71815 1010 42548498
Anger 12.97 11.85 3 71824 13015 42536493
Cerebral artery occlusion 12.97 11.85 11 71816 829 42548679
Influenza like illness 12.97 11.85 21 71806 31819 42517689
Lymphoma 12.95 11.85 4 71823 14317 42535191
Wheezing 12.94 11.85 48 71779 54733 42494775
Stiff tongue 12.88 11.85 3 71824 6 42549502
Microstomia 12.88 11.85 3 71824 6 42549502
Platelet aggregation test 12.82 11.85 4 71823 32 42549476
Cerebral artery embolism 12.71 11.85 12 71815 1041 42548467
Neonatal hypocalcaemia 12.67 11.85 6 71821 160 42549348
Dystonia 12.64 11.85 3 71824 12787 42536721
Blood pressure decreased 12.57 11.85 152 71675 58180 42491328
Squamous cell carcinoma of skin 12.55 11.85 3 71824 12723 42536785
Chronic obstructive pulmonary disease 12.55 11.85 162 71665 62952 42486556
Incarcerated inguinal hernia 12.52 11.85 7 71820 266 42549242
Mitral perforation 12.50 11.85 4 71823 35 42549473
Hepatic cirrhosis 12.46 11.85 9 71818 19693 42529815
Hemiparesis 12.33 11.85 60 71767 17316 42532192
Procedural complication 12.31 11.85 24 71803 4195 42545313
Seizure 12.22 11.85 137 71690 120424 42429084
Lower gastrointestinal haemorrhage 12.16 11.85 43 71784 10765 42538743
Urticaria 12.13 11.85 74 71753 73962 42475546
Venous haemorrhage 12.12 11.85 4 71823 39 42549469
Migraine 12.10 11.85 15 71812 25399 42524109
Soft tissue necrosis 12.06 11.85 8 71819 415 42549093
Dyspepsia 12.03 11.85 33 71794 41319 42508189
Rhinorrhoea 12.00 11.85 22 71805 31772 42517736
Mobility decreased 11.98 11.85 26 71801 35280 42514228
Reperfusion arrhythmia 11.98 11.85 5 71822 98 42549410
Tachycardia 11.97 11.85 238 71589 100849 42448659
Wound 11.94 11.85 7 71820 17110 42532398
Influenza 11.91 11.85 59 71768 62116 42487392
Antibody test positive 11.90 11.85 10 71817 744 42548764
Hepatic artery occlusion 11.88 11.85 5 71822 100 42549408
Neutropenic sepsis 11.88 11.85 6 71821 15940 42533568
Therapeutic response shortened 11.88 11.85 4 71823 13550 42535958
Bronchopulmonary dysplasia 11.87 11.85 10 71817 747 42548761
Spontaneous haematoma 11.86 11.85 10 71817 748 42548760

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heparin-induced thrombocytopenia 8238.27 11.07 2026 123444 9398 110454431
Vascular stent thrombosis 680.41 11.07 233 125237 3928 110459901
Thrombocytopenia 620.03 11.07 1279 124191 347606 110116223
Shock haemorrhagic 572.39 11.07 367 125103 26880 110436949
Haemorrhage 562.99 11.07 649 124821 106043 110357786
Haematoma 523.09 11.07 473 124997 58003 110405826
Pulmonary embolism 513.06 11.07 893 124577 213581 110250248
Multiple organ dysfunction syndrome 485.11 11.07 721 124749 150989 110312840
Thrombosis 480.02 11.07 604 124866 108058 110355771
Cardiogenic shock 472.46 11.07 443 125027 56895 110406934
Labelled drug-drug interaction medication error 431.40 11.07 317 125153 28985 110434844
Premature delivery 425.49 11.07 320 125150 30312 110433517
Cerebral haemorrhage 416.79 11.07 438 125032 64530 110399299
Retroperitoneal haematoma 383.62 11.07 171 125299 5960 110457869
Activated partial thromboplastin time prolonged 358.97 11.07 255 125215 22113 110441716
Haemorrhage intracranial 350.82 11.07 279 125191 28690 110435139
Retroperitoneal haemorrhage 347.25 11.07 159 125311 5906 110457923
Appendicolith 344.71 11.07 210 125260 14045 110449784
Joint swelling 340.20 11.07 49 125421 442796 110021033
Arthralgia 329.23 11.07 243 125227 779389 109684440
Ventricular fibrillation 328.47 11.07 313 125157 41000 110422829
Heparin resistance 321.16 11.07 72 125398 199 110463630
Sepsis 300.01 11.07 934 124536 326412 110137417
Haematoma muscle 297.99 11.07 127 125343 3963 110459866
Thrombosis in device 284.25 11.07 133 125337 5194 110458635
Rheumatoid arthritis 281.70 11.07 14 125456 299599 110164230
Arthropathy 268.52 11.07 14 125456 287508 110176321
Appendicitis 265.85 11.07 236 125234 28228 110435601
Deep vein thrombosis 257.53 11.07 521 124949 139366 110324463
Alopecia 256.58 11.07 51 125419 364702 110099127
Post procedural haemorrhage 253.90 11.07 179 125291 15333 110448496
Cardiac tamponade 251.64 11.07 158 125312 11149 110452680
Acute kidney injury 247.27 11.07 1393 124077 634037 109829792
Fatigue 245.60 11.07 646 124824 1215312 109248517
Cardiac arrest 241.32 11.07 624 124846 196129 110267700
Abdominal discomfort 218.01 11.07 87 125383 393771 110070058
Completed suicide 216.64 11.07 15 125455 242366 110221463
Pemphigus 215.45 11.07 6 125464 214564 110249265
Abdominal wall haematoma 210.97 11.07 111 125359 5594 110458235
Pain 208.45 11.07 487 124983 954468 109509361
Blood phosphorus increased 205.63 11.07 161 125309 16179 110447650
Haemothorax 205.24 11.07 117 125353 6914 110456915
Haemoglobin decreased 200.00 11.07 679 124791 248048 110215781
Psoriatic arthropathy 199.43 11.07 5 125465 196756 110267073
Cerebral infarction 198.96 11.07 269 125201 51569 110412260
Systemic lupus erythematosus 193.20 11.07 29 125441 254309 110209520
Arterial thrombosis 188.77 11.07 85 125385 3034 110460795
Eosinophilia 184.48 11.07 275 125195 57661 110406168
Wound 182.10 11.07 25 125445 234412 110229417
Coagulopathy 179.87 11.07 227 125243 40684 110423145
Pericarditis 175.91 11.07 21 125449 219093 110244736
Spinal epidural haematoma 175.24 11.07 68 125402 1657 110462172
Disseminated intravascular coagulation 170.38 11.07 222 125248 41064 110422765
Septic shock 169.35 11.07 476 124994 157052 110306777
Duodenal ulcer perforation 167.95 11.07 8 125462 177692 110286137
Pericardial haemorrhage 166.36 11.07 92 125378 5125 110458704
Compartment syndrome 163.58 11.07 95 125375 5815 110458014
Muscle haemorrhage 163.02 11.07 100 125370 6769 110457060
Coagulation time prolonged 162.38 11.07 75 125395 2842 110460987
Subarachnoid haemorrhage 155.37 11.07 180 125290 29522 110434307
Adrenal haemorrhage 154.64 11.07 51 125419 761 110463068
Respiratory failure 153.41 11.07 565 124905 214767 110249062
Gastrointestinal haemorrhage 152.99 11.07 474 124996 165044 110298785
Haemoperitoneum 152.83 11.07 88 125382 5300 110458529
Coagulation time shortened 152.22 11.07 43 125427 366 110463463
Hereditary angioedema 149.80 11.07 96 125374 7018 110456811
Brain herniation 149.06 11.07 104 125366 8759 110455070
Myasthenia gravis 148.66 11.07 151 125319 21360 110442469
Depression 148.35 11.07 88 125382 317247 110146582
Peripheral ischaemia 147.96 11.07 113 125357 10945 110452884
Hypotension 147.92 11.07 1059 124411 522790 109941039
Drug reaction with eosinophilia and systemic symptoms 147.74 11.07 303 125167 81792 110382037
Mobility decreased 147.67 11.07 43 125427 237379 110226450
Heparin-induced thrombocytopenia test positive 146.51 11.07 34 125436 115 110463714
Irritable bowel syndrome 144.31 11.07 11 125459 164204 110299625
Anaemia 144.21 11.07 1088 124382 545998 109917831
Autoimmune heparin-induced thrombocytopenia 143.89 11.07 29 125441 37 110463792
Hyperphosphataemia 143.46 11.07 131 125339 16250 110447579
Subdural haematoma 142.67 11.07 191 125279 36263 110427566
Haemodynamic instability 140.85 11.07 151 125319 22737 110441092
Intraventricular haemorrhage 140.55 11.07 84 125386 5423 110458406
Type 2 diabetes mellitus 139.77 11.07 18 125452 177214 110286615
Cardiac ventricular thrombosis 138.93 11.07 69 125401 3078 110460751
Venous thrombosis 138.85 11.07 98 125372 8407 110455422
Osteoarthritis 138.26 11.07 21 125449 182602 110281227
Fibromyalgia 138.12 11.07 16 125454 170893 110292936
Pharyngeal haemorrhage 137.76 11.07 54 125416 1353 110462476
Drug abuse 137.57 11.07 19 125451 177392 110286437
Procedural haemorrhage 136.49 11.07 82 125388 5345 110458484
Malaise 135.86 11.07 356 125114 671463 109792366
Memory impairment 135.38 11.07 29 125441 196915 110266914
Hepatic enzyme increased 135.13 11.07 100 125370 320792 110143037
Vascular pseudoaneurysm 133.91 11.07 74 125396 4116 110459713
Catheter site haemorrhage 132.94 11.07 83 125387 5797 110458032
C-reactive protein abnormal 132.55 11.07 3 125467 129692 110334137
Folliculitis 132.28 11.07 17 125453 167636 110296193
Toxic epidermal necrolysis 131.24 11.07 233 125237 56494 110407335
Peripheral artery thrombosis 131.17 11.07 72 125398 3952 110459877
Analgesic therapy 130.82 11.07 89 125381 7195 110456634
Dizziness 130.03 11.07 385 125085 697808 109766021
Hypersensitivity 127.18 11.07 163 125307 403835 110059994
Impaired healing 125.35 11.07 34 125436 196683 110267146
Coronary artery thrombosis 125.33 11.07 65 125405 3179 110460650
Toxicity to various agents 125.07 11.07 221 125249 480334 109983495
Nasopharyngitis 124.26 11.07 159 125311 394202 110069627
Ascites 123.77 11.07 304 125166 92504 110371325
Ill-defined disorder 123.52 11.07 16 125454 156837 110306992
Intra-abdominal haemorrhage 122.28 11.07 76 125394 5266 110458563
Venoocclusive disease 122.23 11.07 81 125389 6269 110457560
Sleep disorder therapy 121.77 11.07 86 125384 7385 110456444
Exposure during pregnancy 121.49 11.07 442 125028 166982 110296847
Drug intolerance 120.88 11.07 171 125299 406341 110057488
Drug therapy 119.00 11.07 84 125386 7207 110456622
Extradural haematoma 117.38 11.07 63 125407 3306 110460523
Intracardiac thrombus 116.52 11.07 68 125402 4200 110459629
Off label use 115.45 11.07 2361 123109 1497824 108966005
Rash 114.36 11.07 511 124959 820453 109643376
Peripheral swelling 113.29 11.07 177 125293 403857 110059972
Arthritis 112.51 11.07 26 125444 167560 110296269
Acute myocardial infarction 110.21 11.07 273 125197 83504 110380325
Atrial thrombosis 110.16 11.07 66 125404 4280 110459549
Drug ineffective 109.81 11.07 2371 123099 1518169 108945660
Rash maculo-papular 109.64 11.07 253 125217 73969 110389860
Muscle spasms 107.94 11.07 94 125376 278063 110185766
Aplastic anaemia 107.04 11.07 135 125335 24173 110439656
Psoriasis 106.19 11.07 16 125454 139977 110323852
Bursitis 105.37 11.07 12 125458 129906 110333923
Discomfort 103.95 11.07 57 125413 214650 110249179
Intentional overdose 103.17 11.07 14 125456 132487 110331342
Weight increased 102.95 11.07 200 125270 419444 110044385
Haematuria 102.42 11.07 264 125206 82741 110381088
Cerebral haematoma 102.37 11.07 86 125384 9546 110454283
Joint range of motion decreased 102.03 11.07 10 125460 121822 110342007
Embolism 101.18 11.07 108 125362 16181 110447648
Injury 99.90 11.07 38 125432 177227 110286602
Aortic thrombosis 99.74 11.07 49 125421 2134 110461695
Injection site pain 98.85 11.07 39 125431 177883 110285946
Antacid therapy 98.47 11.07 67 125403 5417 110458412
Insomnia 98.21 11.07 161 125309 360429 110103400
Diarrhoea 98.12 11.07 825 124645 1138680 109325149
Upper gastrointestinal haemorrhage 97.42 11.07 191 125279 49905 110413924
Skin necrosis 97.16 11.07 121 125349 21391 110442438
Infusion related reaction 96.70 11.07 178 125292 380984 110082845
Inflammation 95.45 11.07 50 125420 193188 110270641
Product use in unapproved indication 94.23 11.07 846 124624 446531 110017298
Asthma 94.21 11.07 87 125383 250204 110213625
Maternal exposure during pregnancy 93.68 11.07 551 124919 254332 110209497
Musculoskeletal stiffness 93.20 11.07 108 125362 279714 110184115
Facet joint syndrome 92.65 11.07 4 125466 96824 110367005
Wheezing 92.24 11.07 92 125378 255138 110208691
Pulseless electrical activity 91.77 11.07 104 125366 16653 110447176
Night sweats 91.52 11.07 20 125450 133963 110329866
Hypophosphataemia 90.94 11.07 147 125323 33035 110430794
Suicide attempt 90.62 11.07 7 125463 103387 110360442
Decreased appetite 90.22 11.07 260 125210 475586 109988243
Bacterial infection 90.10 11.07 176 125294 45860 110417969
Encephalopathy 90.09 11.07 248 125222 80807 110383022
Haemorrhagic transformation stroke 89.89 11.07 51 125419 2986 110460843
Blood creatinine increased 88.84 11.07 427 125043 182462 110281367
Coagulation time abnormal 88.22 11.07 24 125446 175 110463654
Pulmonary haemorrhage 88.20 11.07 101 125369 16355 110447474
Stevens-Johnson syndrome 86.61 11.07 175 125295 46726 110417103
Arterial haemorrhage 86.57 11.07 54 125416 3765 110460064
Hyperkalaemia 86.53 11.07 344 125126 135452 110328377
Blood uric acid increased 86.08 11.07 114 125356 21415 110442414
Treatment failure 86.02 11.07 113 125357 277121 110186708
Confusional state 86.02 11.07 260 125210 468420 109995409
Hypoxia 84.06 11.07 330 125140 129185 110334644
Vena cava thrombosis 83.25 11.07 51 125419 3443 110460386
Peripheral venous disease 82.09 11.07 3 125467 84114 110379715
Loss of personal independence in daily activities 81.52 11.07 34 125436 149986 110313843
Choroidal infarction 81.39 11.07 23 125447 196 110463633
Stomatitis 80.96 11.07 113 125357 270129 110193700
Suicidal ideation 80.56 11.07 7 125463 93930 110369899
Hypercoagulation 80.41 11.07 49 125421 3277 110460552
Epistaxis 79.67 11.07 326 125144 130046 110333783
Haemorrhagic infarction 79.64 11.07 32 125438 857 110462972
Obesity 79.31 11.07 16 125454 113335 110350494
Vascular stent occlusion 79.28 11.07 24 125446 266 110463563
Iron deficiency 78.80 11.07 101 125369 18375 110445454
Coagulation time 78.24 11.07 14 125456 3 110463826
Therapeutic product effect incomplete 78.23 11.07 83 125387 223722 110240107
Grip strength decreased 77.76 11.07 3 125467 80171 110383658
Headache 77.57 11.07 635 124835 881742 109582087
Abdominal pain upper 77.52 11.07 176 125294 348935 110114894
Weight decreased 77.33 11.07 272 125198 467785 109996044
Platelet count decreased 76.33 11.07 485 124985 229958 110233871
Haemoptysis 76.03 11.07 215 125255 71139 110392690
Gait inability 75.58 11.07 30 125440 136346 110327483
Hypoaesthesia 75.10 11.07 152 125318 314071 110149758
Gait disturbance 75.00 11.07 125 125345 278083 110185746
Dyspepsia 74.71 11.07 64 125406 190901 110272928
End stage renal disease 74.25 11.07 106 125364 21367 110442462
Ischaemic stroke 73.87 11.07 152 125318 41111 110422718
Acute respiratory distress syndrome 72.77 11.07 176 125294 53022 110410807
Melaena 72.11 11.07 206 125264 68551 110395278
Pulmonary alveolar haemorrhage 71.94 11.07 101 125369 20049 110443780
Shock 71.93 11.07 176 125294 53412 110410417
Sinusitis 71.34 11.07 143 125327 296545 110167284
Anxiety 71.04 11.07 181 125289 344897 110118932
Pain in extremity 70.24 11.07 299 125171 486819 109977010
Orbital compartment syndrome 70.21 11.07 18 125452 101 110463728
Blood pressure decreased 69.69 11.07 287 125183 114804 110349025
Bullous haemorrhagic dermatosis 69.69 11.07 23 125447 344 110463485
Splenic rupture 69.32 11.07 41 125429 2596 110461233
Acute generalised exanthematous pustulosis 69.19 11.07 103 125367 21561 110442268
Respiratory distress 69.01 11.07 203 125267 68671 110395158
Lower respiratory tract infection 68.57 11.07 106 125364 243000 110220829
Musculoskeletal pain 68.41 11.07 64 125406 182959 110280870
Product measured potency issue 67.83 11.07 20 125450 201 110463628
Renal infarct 67.03 11.07 44 125426 3351 110460478
Sciatica 66.86 11.07 12 125458 92387 110371442
Heparin-induced thrombocytopenia test 66.79 11.07 20 125450 213 110463616
Hypoaldosteronism 66.64 11.07 26 125444 643 110463186
Ventricular tachycardia 65.80 11.07 163 125307 49846 110413983
Cerebral venous sinus thrombosis 65.79 11.07 41 125429 2854 110460975
Blood loss anaemia 65.32 11.07 91 125379 17934 110445895
Blister 65.22 11.07 98 125372 227278 110236551
Stress 64.81 11.07 264 125206 105084 110358745
Vascular access site haemorrhage 64.55 11.07 20 125450 241 110463588
Product administration error 64.17 11.07 135 125335 37082 110426747
Subcapsular renal haematoma 63.83 11.07 28 125442 938 110462891
Coronary artery perforation 63.78 11.07 16 125454 81 110463748
Transfusion 63.30 11.07 108 125362 25364 110438465
Asthenia 62.71 11.07 491 124979 688508 109775321
Anticoagulation drug level below therapeutic 62.03 11.07 33 125437 1701 110462128
Autoimmune disorder 61.69 11.07 3 125467 65480 110398349
Pulmonary haematoma 61.67 11.07 17 125453 131 110463698
Venoocclusive liver disease 61.53 11.07 81 125389 15126 110448703
Splenic infarction 61.40 11.07 46 125424 4328 110459501
Anticoagulation drug level above therapeutic 61.25 11.07 47 125423 4583 110459246
Oesophageal intramural haematoma 61.22 11.07 18 125452 179 110463650
Electrocardiogram ST segment elevation 60.93 11.07 63 125407 9097 110454732
Adverse event 60.18 11.07 24 125446 108785 110355044
Blood urea increased 59.92 11.07 167 125303 54790 110409039
Brain oedema 58.57 11.07 117 125353 30981 110432848
Knee arthroplasty 58.05 11.07 4 125466 64944 110398885
Puncture site haemorrhage 57.56 11.07 24 125446 708 110463121
Renal failure 57.51 11.07 447 125023 226127 110237702
Acute respiratory failure 57.38 11.07 202 125268 75058 110388771
Gastrointestinal disorder 56.98 11.07 118 125352 241834 110221995
Pruritus 56.92 11.07 406 125064 581154 109882675
Cerebral mass effect 56.85 11.07 35 125435 2384 110461445
Migraine 56.32 11.07 67 125403 171585 110292244
Lower limb fracture 56.25 11.07 9 125461 75339 110388490
Paraesthesia 56.16 11.07 146 125324 276375 110187454
Troponin increased 56.07 11.07 112 125358 29654 110434175
Urticaria 55.55 11.07 181 125289 318676 110145153
Suspected product quality issue 55.18 11.07 22 125448 577 110463252
Abdominal distension 54.58 11.07 363 125107 174740 110289089
Frequent bowel movements 54.50 11.07 8 125462 71382 110392447
Subchorionic haematoma 54.48 11.07 15 125455 115 110463714
Gastrooesophageal reflux disease 54.14 11.07 75 125395 179901 110283928
Adverse drug reaction 54.09 11.07 26 125444 105533 110358296
Prosthetic cardiac valve thrombosis 53.39 11.07 14 125456 87 110463742
Peripheral artery occlusion 53.37 11.07 36 125434 2869 110460960
Antiphospholipid syndrome 53.01 11.07 34 125436 2489 110461340
Immune thrombocytopenia 52.80 11.07 93 125377 22401 110441428
Fall 52.61 11.07 435 125035 603047 109860782
Embolic stroke 52.60 11.07 57 125413 8686 110455143
Pulmonary infarction 52.44 11.07 41 125429 4110 110459719
Deep vein thrombosis postoperative 52.00 11.07 4 125466 59287 110404542
Hypovolaemic shock 51.92 11.07 73 125397 14510 110449319
Vasodilatation 51.72 11.07 39 125431 3705 110460124
Orbital haematoma 51.22 11.07 11 125459 23 110463806
Myalgia 51.07 11.07 110 125360 222271 110241558
Pulmonary fibrosis 50.97 11.07 26 125444 102016 110361813
Red blood cell sedimentation rate increased 50.88 11.07 13 125457 78289 110385540
Taste disorder 50.68 11.07 7 125463 65380 110398449
Thrombotic microangiopathy 50.56 11.07 106 125364 29043 110434786
Injection site reaction 50.33 11.07 19 125451 89051 110374778
Blepharospasm 50.15 11.07 3 125467 54848 110408981
Intra-abdominal haematoma 49.82 11.07 37 125433 3435 110460394
Contraindicated product administered 49.71 11.07 132 125338 248135 110215694
Mediastinal haematoma 49.38 11.07 16 125454 225 110463604
Wound infection 49.06 11.07 24 125446 96441 110367388
Aortic stenosis 48.93 11.07 67 125403 12992 110450837
Serratia infection 48.84 11.07 31 125439 2228 110461601
Intentional product use issue 48.74 11.07 133 125337 247773 110216056
Leukocytosis 48.62 11.07 153 125317 53675 110410154
Infection 48.17 11.07 229 125241 361971 110101858
Obstructive shock 47.73 11.07 14 125456 138 110463691
Blood pressure fluctuation 47.52 11.07 13 125457 74811 110389018
Hyponatraemia 47.49 11.07 415 125055 217238 110246591
Jugular vein thrombosis 47.30 11.07 43 125427 5302 110458527
Sleep disorder due to a general medical condition 47.19 11.07 3 125467 52109 110411720
Amnesia 46.77 11.07 31 125439 105377 110358452
Incision site pain 46.32 11.07 34 125436 3101 110460728
Intestinal ischaemia 46.15 11.07 73 125397 16106 110447723
Haemorrhagic stroke 46.11 11.07 67 125403 13722 110450107
Balance disorder 45.66 11.07 39 125431 116521 110347308
Congenital hiatus hernia 45.20 11.07 45 125425 6214 110457615
Diabetes insipidus 45.18 11.07 46 125424 6524 110457305
Brain death 45.16 11.07 46 125424 6527 110457302
Hepatic haematoma 45.11 11.07 22 125448 943 110462886
Oliguria 44.91 11.07 78 125392 18579 110445250
Neuralgia 44.90 11.07 139 125331 48339 110415490
Incorrect route of product administration 44.65 11.07 167 125303 63894 110399935
Visual impairment 44.60 11.07 52 125418 134376 110329453
Vascular graft occlusion 44.49 11.07 20 125450 711 110463118
Road traffic accident 44.48 11.07 34 125436 107364 110356465
Drug ineffective for unapproved indication 44.19 11.07 232 125238 102606 110361223
Cerebral reperfusion injury 44.00 11.07 10 125460 30 110463799
Cholestasis 43.98 11.07 167 125303 64351 110399478
Bacteroides infection 43.90 11.07 32 125438 2887 110460942
Total lung capacity decreased 43.88 11.07 47 125423 7067 110456762
Dry gangrene 43.07 11.07 22 125448 1042 110462787
Gastrointestinal necrosis 42.97 11.07 45 125425 6595 110457234
Cerebellar haemorrhage 42.83 11.07 33 125437 3238 110460591
Lymphocyte count decreased 41.38 11.07 151 125319 57092 110406737
Haemorrhagic cerebral infarction 41.29 11.07 24 125446 1471 110462358
Haemarthrosis 41.01 11.07 46 125424 7283 110456546
Mixed liver injury 40.84 11.07 59 125411 12020 110451809
Spinal subdural haematoma 40.82 11.07 14 125456 237 110463592
Graft thrombosis 40.79 11.07 17 125453 501 110463328
Injection site swelling 40.65 11.07 10 125460 61780 110402049
Hypervolaemia 40.53 11.07 136 125334 49324 110414505
Splenic haematoma 40.43 11.07 15 125455 322 110463507
Swelling 39.94 11.07 234 125236 350807 110113022
Spinal cord compression 39.88 11.07 46 125424 7506 110456323
C-reactive protein increased 39.84 11.07 121 125349 217798 110246031
Serratia sepsis 39.37 11.07 14 125456 265 110463564
Nervous system disorder 39.23 11.07 101 125369 31620 110432209
Infective aneurysm 38.71 11.07 23 125447 1469 110462360
Hydrocephalus 38.52 11.07 53 125417 10322 110453507
Contusion 38.23 11.07 136 125334 233225 110230604
Colitis ulcerative 38.21 11.07 20 125450 77343 110386486
Anti factor Xa activity decreased 38.19 11.07 8 125462 14 110463815
Hyperlactacidaemia 38.05 11.07 47 125423 8239 110455590
Iliac artery occlusion 38.00 11.07 15 125455 383 110463446
Exostosis 37.88 11.07 4 125466 45952 110417877
Blood calcium increased 37.79 11.07 71 125399 17969 110445860
Device related sepsis 37.76 11.07 45 125425 7602 110456227
Onychomadesis 37.57 11.07 4 125466 45659 110418170
Increased viscosity of upper respiratory secretion 37.54 11.07 17 125453 615 110463214
Activated partial thromboplastin time shortened 37.48 11.07 20 125450 1037 110462792
Ventricle rupture 37.45 11.07 11 125459 109 110463720
Anti factor V antibody 37.41 11.07 14 125456 308 110463521
Coagulation test abnormal 37.41 11.07 23 125447 1563 110462266
Pulmonary artery thrombosis 37.19 11.07 23 125447 1579 110462250
Device related thrombosis 36.97 11.07 31 125439 3431 110460398
Chest wall haematoma 36.96 11.07 16 125454 519 110463310
Back injury 36.91 11.07 5 125465 47394 110416435
Acute motor-sensory axonal neuropathy 36.87 11.07 16 125454 522 110463307
Medical device site thrombosis 36.75 11.07 11 125459 117 110463712
Right ventricular failure 36.71 11.07 87 125383 25867 110437962
Cerebral hyperperfusion syndrome 36.66 11.07 11 125459 118 110463711
Tongue haematoma 36.37 11.07 13 125457 250 110463579
Ischaemia 36.16 11.07 48 125422 9035 110454794
Vascular graft thrombosis 36.13 11.07 13 125457 255 110463574
Peritoneal haematoma 36.13 11.07 13 125457 255 110463574
Foot deformity 35.72 11.07 6 125464 48474 110415355
Platelet transfusion 35.71 11.07 28 125442 2818 110461011
Product contamination 35.64 11.07 24 125446 1907 110461922
Cardiac procedure complication 35.63 11.07 14 125456 353 110463476
Hemiparesis 35.34 11.07 120 125350 43783 110420046
Joint stiffness 35.31 11.07 16 125454 67227 110396602
Drug dependence 35.11 11.07 7 125463 50013 110413816
Lupus-like syndrome 35.08 11.07 3 125467 40789 110423040
Bronchial haemorrhage 34.99 11.07 21 125449 1366 110462463
Suspected transmission of an infectious agent via product 34.81 11.07 21 125449 1379 110462450
Premature rupture of membranes 34.71 11.07 34 125436 4603 110459226
Dysgeusia 34.70 11.07 18 125452 69967 110393862
Unresponsive to stimuli 34.69 11.07 154 125316 63636 110400193
Primary adrenal insufficiency 34.60 11.07 16 125454 608 110463221
Coronary artery dissection 34.38 11.07 20 125450 1228 110462601
Osteoporosis 34.33 11.07 29 125441 87123 110376706
Epilepsy 34.07 11.07 38 125432 100171 110363658
Feeling abnormal 34.00 11.07 99 125371 180612 110283217
Intrapericardial thrombosis 33.78 11.07 9 125461 60 110463769
Tachypnoea 33.78 11.07 110 125360 39285 110424544
Haemorrhagic cholecystitis 33.74 11.07 11 125459 158 110463671
Pulse absent 33.67 11.07 52 125418 11240 110452589
Renal vein thrombosis 33.59 11.07 19 125451 1106 110462723
Gastroduodenal ulcer 33.39 11.07 18 125452 953 110462876
Hepatic infarction 33.21 11.07 18 125452 963 110462866
Spontaneous haematoma 32.95 11.07 23 125447 1938 110461891
Aortic dissection 32.94 11.07 34 125436 4899 110458930
Procedural complication 32.82 11.07 44 125426 8361 110455468
Ocular retrobulbar haemorrhage 32.76 11.07 11 125459 174 110463655
Atrial fibrillation 32.53 11.07 401 125069 229241 110234588
Basal cell carcinoma 32.49 11.07 6 125464 45264 110418565
Prescribed overdose 32.28 11.07 31 125439 87550 110376279
Tachycardia 32.21 11.07 396 125074 226249 110237580
International normalised ratio increased 32.10 11.07 188 125282 86584 110377245
Psychotic disorder 32.06 11.07 9 125461 50928 110412901
Factor Xa activity increased 31.87 11.07 7 125463 17 110463812
Aspartate aminotransferase increased 31.84 11.07 299 125171 159637 110304192
Protein C decreased 31.71 11.07 9 125461 78 110463751
Red blood cells urine positive 31.53 11.07 34 125436 5151 110458678
Platelet aggregation inhibition 31.39 11.07 11 125459 199 110463630
Gastric haemorrhage 31.32 11.07 61 125409 15854 110447975
Aggression 31.23 11.07 14 125456 59196 110404633
Accidental exposure to product 31.18 11.07 9 125461 49999 110413830
Vaginal haemorrhage 31.18 11.07 80 125390 24994 110438835
Lung opacity 31.08 11.07 51 125419 11601 110452228
Bleeding time prolonged 31.01 11.07 19 125451 1283 110462546
Abdominal compartment syndrome 30.98 11.07 22 125448 1905 110461924
Device related infection 30.92 11.07 107 125363 39412 110424417
Cardiac valve replacement complication 30.70 11.07 11 125459 213 110463616
Mouth haemorrhage 30.67 11.07 55 125415 13433 110450396
Spinal cord haematoma 30.56 11.07 12 125458 302 110463527
Pituitary apoplexy 30.52 11.07 12 125458 303 110463526
Gout 30.37 11.07 101 125369 36465 110427364
Pericardial effusion 30.26 11.07 137 125333 57080 110406749
Sedation 30.23 11.07 21 125449 69662 110394167
Cognitive disorder 29.95 11.07 33 125437 87478 110376351
Hypernatraemia 29.94 11.07 64 125406 17769 110446060
Circulatory collapse 29.89 11.07 112 125358 42881 110420948
Hot flush 29.87 11.07 19 125451 66017 110397812
Caesarean section 29.72 11.07 55 125415 13762 110450067
Drug effect less than expected 29.63 11.07 39 125431 7281 110456548
Injection site erythema 29.58 11.07 38 125432 94138 110369691
Haematemesis 29.39 11.07 139 125331 58969 110404860
Coronary vascular graft occlusion 29.21 11.07 6 125464 9 110463820
Anti-platelet antibody 29.21 11.07 6 125464 9 110463820
Cerebral artery embolism 29.18 11.07 22 125448 2090 110461739
Renal artery stenosis 29.17 11.07 28 125442 3698 110460131
Blood albumin decreased 29.13 11.07 83 125387 27569 110436260
Gangrene 29.01 11.07 60 125410 16281 110447548
Acquired antithrombin III deficiency 28.91 11.07 5 125465 0 110463829
Fibrin D dimer increased 28.88 11.07 45 125425 9800 110454029
Embolic cerebral infarction 28.48 11.07 19 125451 1487 110462342
Therapeutic product effect increased 28.44 11.07 20 125450 1705 110462124
Nightmare 28.21 11.07 5 125465 38858 110424971
Dry eye 28.19 11.07 14 125456 55779 110408050
Neutrophil count increased 28.14 11.07 95 125375 34557 110429272
Hyperlipidaemia 28.00 11.07 97 125373 35751 110428078
Phaeochromocytoma crisis 27.94 11.07 13 125457 501 110463328
Underdose 27.78 11.07 19 125451 63535 110400294
Renal haemorrhage 27.78 11.07 23 125447 2502 110461327
Aspiration 27.77 11.07 87 125383 30446 110433383
Purpura 27.47 11.07 75 125395 24313 110439516
Ischaemic hepatitis 27.43 11.07 30 125440 4618 110459211
Reperfusion injury 27.33 11.07 10 125460 206 110463623
Lower gastrointestinal haemorrhage 27.27 11.07 63 125407 18423 110445406
Injection site pruritus 27.23 11.07 12 125458 51246 110412583
Hypercholesterolaemia 27.16 11.07 38 125432 90799 110373030
Rash morbilliform 27.12 11.07 39 125431 7912 110455917
Femoral nerve palsy 26.82 11.07 8 125462 84 110463745
Bronchopulmonary aspergillosis allergic 26.82 11.07 40 125430 8386 110455443
Intentional self-injury 26.78 11.07 5 125465 37424 110426405
Pelvic haematoma 26.77 11.07 16 125454 1033 110462796
Hip arthroplasty 26.73 11.07 15 125455 55798 110408031
Spontaneous heparin-induced thrombocytopenia syndrome 26.57 11.07 5 125465 3 110463826
Transaminases increased 26.54 11.07 142 125328 63248 110400581
Incorrect drug administration rate 26.52 11.07 32 125438 5476 110458353
Insurance issue 26.37 11.07 45 125425 10567 110453262
Kounis syndrome 26.23 11.07 33 125437 5892 110457937
Herpes zoster 26.23 11.07 52 125418 108327 110355502
Pelvic venous thrombosis 25.97 11.07 23 125447 2741 110461088
Fungal sepsis 25.92 11.07 21 125449 2216 110461613
Procedural hypotension 25.87 11.07 22 125448 2483 110461346
Malignant neoplasm progression 25.83 11.07 106 125364 174461 110289368
Rectosigmoid cancer 25.75 11.07 11 125459 345 110463484
Pancreatic haemorrhage 25.70 11.07 8 125462 98 110463731
Arterial intramural haematoma 25.60 11.07 10 125460 248 110463581
Thrombectomy 25.12 11.07 11 125459 367 110463462
Dermatitis bullous 25.05 11.07 59 125411 17470 110446359
Cataract 25.04 11.07 32 125438 79453 110384376
Neck pain 24.99 11.07 65 125405 123065 110340764
Splenic haemorrhage 24.89 11.07 14 125456 806 110463023
Post procedural haematoma 24.87 11.07 22 125448 2617 110461212
Metabolic acidosis 24.85 11.07 196 125274 99548 110364281
Endocarditis 24.81 11.07 50 125420 13321 110450508
Cardio-respiratory arrest 24.80 11.07 220 125250 115616 110348213
No adverse event 24.79 11.07 156 125314 73683 110390146
Toxoplasmosis 24.71 11.07 24 125446 3215 110460614
Spontaneous haemorrhage 24.69 11.07 16 125454 1192 110462637
Portal vein thrombosis 24.63 11.07 35 125435 7023 110456806
Myocardial haemorrhage 24.63 11.07 7 125463 61 110463768
Hepatic artery thrombosis 24.63 11.07 11 125459 385 110463444
Foetal death 24.02 11.07 55 125415 15990 110447839
Sopor 23.87 11.07 6 125464 36540 110427289
Choroidal effusion 23.82 11.07 14 125456 876 110462953
Cerebral artery occlusion 23.81 11.07 19 125451 1961 110461868
Wrong technique in product usage process 23.75 11.07 39 125431 87309 110376520
Staphylococcal infection 23.62 11.07 148 125322 69796 110394033
Paraplegia 23.52 11.07 32 125438 6168 110457661
Mediastinal haemorrhage 23.42 11.07 7 125463 74 110463755
Rhinorrhoea 23.38 11.07 51 125419 102615 110361214
Left ventricular dysfunction 23.29 11.07 69 125401 23424 110440405
Ocular ischaemic syndrome 23.21 11.07 6 125464 35 110463794
Cerebral microembolism 23.13 11.07 4 125466 0 110463829
Drug chemical incompatibility 23.13 11.07 8 125462 139 110463690
Aneurysm ruptured 23.06 11.07 15 125455 1125 110462704
Pulmonary oedema 23.03 11.07 194 125276 100465 110363364
Premature labour 22.94 11.07 39 125431 9133 110454696
Venous thrombosis limb 22.80 11.07 29 125441 5236 110458593
Ventricular arrhythmia 22.77 11.07 41 125429 10046 110453783
Cerebral venous thrombosis 22.72 11.07 23 125447 3239 110460590
Peritonitis 22.71 11.07 85 125385 32522 110431307
Hemiplegia 22.67 11.07 67 125403 22715 110441114
Renal haematoma 22.54 11.07 14 125456 969 110462860
Allergic reaction to excipient 22.53 11.07 13 125457 786 110463043
Poor venous access 22.42 11.07 70 125400 24452 110439377
Subcutaneous haematoma 22.24 11.07 22 125448 3014 110460815
Back pain 22.20 11.07 292 125178 370704 110093125
Infusion site extravasation 22.18 11.07 44 125426 11590 110452239
Hepatic cytolysis 22.15 11.07 122 125348 54931 110408898
Staphylococcus test positive 22.06 11.07 34 125436 7336 110456493
Blood aldosterone decreased 22.00 11.07 5 125465 15 110463814
COVID-19 pneumonia 21.98 11.07 92 125378 37051 110426778
Kidney rupture 21.89 11.07 9 125461 256 110463573
Intracranial haematoma 21.89 11.07 14 125456 1020 110462809
Myocardial calcification 21.86 11.07 9 125461 257 110463572
Coronary artery aneurysm 21.86 11.07 8 125462 165 110463664
Livedo reticularis 21.77 11.07 29 125441 5477 110458352
Disability 21.70 11.07 4 125466 30219 110433610
Mucosal erosion 21.69 11.07 21 125449 2803 110461026
Lung disorder 21.55 11.07 118 125352 179929 110283900
Vascular access site haematoma 21.53 11.07 5 125465 17 110463812
Death 21.52 11.07 616 124854 698253 109765576
Anaphylactic shock 21.26 11.07 115 125355 51431 110412398
Duodenal ulcer haemorrhage 21.20 11.07 35 125435 8002 110455827
Muscular weakness 21.20 11.07 180 125290 248288 110215541
Incision site haematoma 21.17 11.07 8 125462 181 110463648
Ulcer 21.15 11.07 101 125369 43015 110420814
Anaphylactoid reaction 21.15 11.07 32 125438 6794 110457035
Leg amputation 21.12 11.07 25 125445 4193 110459636
Renal artery thrombosis 21.10 11.07 11 125459 544 110463285
Klebsiella infection 21.02 11.07 60 125410 19949 110443880
Drug interaction 20.92 11.07 728 124742 499455 109964374
Petechiae 20.80 11.07 66 125404 23251 110440578
Prescribed underdose 20.78 11.07 26 125444 65148 110398681
Vertigo 20.75 11.07 42 125428 86828 110377001
Haemolysis 20.59 11.07 51 125419 15588 110448241
Vision blurred 20.59 11.07 76 125394 128946 110334883
Clostridium test positive 20.53 11.07 41 125429 10852 110452977
Device occlusion 20.51 11.07 50 125420 15135 110448694
Medical device site haemorrhage 20.50 11.07 8 125462 198 110463631
Acute right ventricular failure 20.37 11.07 10 125460 435 110463394
Blood test abnormal 20.36 11.07 75 125395 28479 110435350
Hypoprothrombinaemia 20.34 11.07 13 125457 946 110462883
Product use issue 20.27 11.07 241 125229 311454 110152375
Mouth ulceration 20.24 11.07 15 125455 48123 110415706
Osteonecrosis of jaw 20.14 11.07 15 125455 48002 110415827
Haemorrhage subcutaneous 20.12 11.07 28 125442 5511 110458318
Impaired work ability 20.07 11.07 3 125467 26416 110437413
Eosinophil cationic protein increased 19.94 11.07 6 125464 65 110463764
Blood pressure systolic increased 19.93 11.07 40 125430 82951 110380878
Extravasation 19.90 11.07 26 125444 4819 110459010
Tendonitis 19.73 11.07 3 125467 26080 110437749
Catheter site pain 19.66 11.07 30 125440 6416 110457413
Paralysis 19.63 11.07 50 125420 15550 110448279
Calciphylaxis 19.63 11.07 24 125446 4163 110459666
Central venous catheterisation 19.62 11.07 23 125447 3819 110460010
Impaired quality of life 19.47 11.07 5 125465 30012 110433817
Enterococcus test positive 19.36 11.07 20 125450 2884 110460945
Delayed graft function 19.31 11.07 24 125446 4233 110459596
Stillbirth 19.28 11.07 24 125446 4240 110459589
Bradycardia 19.26 11.07 265 125205 155252 110308577
Poor quality product administered 19.21 11.07 25 125445 4616 110459213
Eye irritation 19.12 11.07 7 125463 33445 110430384
Aneurysm recanalisation 19.09 11.07 4 125466 7 110463822
Capillary fragility test 19.08 11.07 5 125465 31 110463798
Adverse reaction 19.06 11.07 5 125465 29589 110434240
Protein urine present 19.03 11.07 41 125429 11443 110452386
Pleural effusion 18.93 11.07 295 125175 177414 110286415
Pregnancy 18.90 11.07 18 125452 51049 110412780
HELLP syndrome 18.89 11.07 12 125458 864 110462965
Acute pulmonary oedema 18.87 11.07 52 125418 16944 110446885
Protein S decreased 18.79 11.07 7 125463 152 110463677
Incision site haemorrhage 18.73 11.07 13 125457 1085 110462744
Retinal pigment epitheliopathy 18.71 11.07 10 125460 520 110463309
Coagulation factor VIII level increased 18.68 11.07 5 125465 34 110463795
Premature separation of placenta 18.66 11.07 15 125455 1565 110462264
Renal impairment 18.64 11.07 309 125161 188136 110275693
Neuropathy peripheral 18.56 11.07 123 125347 179154 110284675
Antithrombin III deficiency 18.54 11.07 7 125463 158 110463671
Vasospasm 18.53 11.07 15 125455 1581 110462248
Necrotising oesophagitis 18.49 11.07 15 125455 1585 110462244
Enterococcal infection 18.49 11.07 58 125412 20308 110443521
Lip erosion 18.48 11.07 16 125454 1850 110461979
False negative investigation result 18.32 11.07 9 125461 392 110463437
Liver injury 18.32 11.07 98 125372 150315 110313514
Ear pain 18.29 11.07 20 125450 53206 110410623
Pharyngeal haematoma 18.26 11.07 7 125463 165 110463664
Post procedural complication 18.16 11.07 69 125401 26589 110437240
Laryngitis 18.11 11.07 13 125457 42398 110421431
Paratonia 18.08 11.07 5 125465 39 110463790
Pre-eclampsia 18.06 11.07 34 125436 8616 110455213
Oral mucosal eruption 17.92 11.07 13 125457 1164 110462665
Intracranial pressure increased 17.91 11.07 38 125432 10497 110453332
Blood blister 17.90 11.07 22 125448 3837 110459992
Chronic obstructive pulmonary disease 17.85 11.07 196 125274 108962 110354867
Sleep apnoea syndrome 17.80 11.07 12 125458 40435 110423394
Catheter site haematoma 17.78 11.07 9 125461 418 110463411
Ventricular asystole 17.74 11.07 9 125461 420 110463409
Pyrexia 17.70 11.07 1214 124256 897051 109566778
Bronchopulmonary aspergillosis 17.70 11.07 74 125396 29789 110434040
Skin ulcer 17.69 11.07 28 125442 63617 110400212
Tonsillar haemorrhage 17.65 11.07 8 125462 290 110463539
Waterhouse-Friderichsen syndrome 17.60 11.07 4 125466 12 110463817
Pneumothorax 17.56 11.07 83 125387 35202 110428627
Thrombotic stroke 17.50 11.07 11 125459 777 110463052
Anisochromia 17.35 11.07 3 125467 0 110463829
Peliosis hepatis 17.33 11.07 7 125463 190 110463639
Catheter site swelling 17.32 11.07 17 125453 2307 110461522
Dystonia 17.32 11.07 4 125466 25801 110438028
Coronary artery occlusion 17.26 11.07 48 125422 15724 110448105
Multiple sclerosis 17.21 11.07 4 125466 25694 110438135
Burkholderia test positive 17.19 11.07 10 125460 614 110463215
Hypertension 17.14 11.07 444 125026 509640 109954189
Movement disorder 17.12 11.07 10 125460 36394 110427435
White blood cell count decreased 17.05 11.07 172 125298 229218 110234611
Influenza 17.01 11.07 117 125353 168984 110294845
Mean cell haemoglobin concentration 16.98 11.07 5 125465 50 110463779
Cerebrovascular disorder 16.96 11.07 21 125449 3690 110460139
Influenza like illness 16.94 11.07 48 125422 88364 110375465
Arterial injury 16.93 11.07 11 125459 823 110463006
Eating disorder 16.75 11.07 7 125463 30851 110432978
Orthostatic hypotension 16.72 11.07 31 125439 66218 110397611
Transcription medication error 16.71 11.07 10 125460 647 110463182
Haemolytic anaemia 16.68 11.07 57 125413 20863 110442966
Abnormal behaviour 16.63 11.07 12 125458 39027 110424802
Nephritis allergic 16.62 11.07 12 125458 1067 110462762
Adrenomegaly 16.60 11.07 9 125461 482 110463347
Pleuritic pain 16.57 11.07 48 125422 16092 110447737
Threatened labour 16.56 11.07 10 125460 658 110463171
Prothrombin time prolonged 16.45 11.07 50 125420 17211 110446618
Bacteraemia 16.43 11.07 93 125377 42297 110421532
Tricuspid valve stenosis 16.33 11.07 4 125466 18 110463811
Postpartum haemorrhage 16.33 11.07 15 125455 1874 110461955
Atrial rupture 16.23 11.07 5 125465 59 110463770
Arterial rupture 16.21 11.07 11 125459 885 110462944
Right atrial pressure increased 16.21 11.07 8 125462 352 110463477
Peripheral artery aneurysm 16.20 11.07 9 125461 506 110463323
Thrombin time abnormal 16.16 11.07 4 125466 19 110463810
Platelet dysfunction 16.13 11.07 9 125461 510 110463319
Opportunistic infection 16.11 11.07 20 125450 3523 110460306
Dyspnoea 16.11 11.07 1061 124409 1105811 109358018
Cerebrovascular accident 16.04 11.07 292 125178 180992 110282837
Haemodialysis complication 16.02 11.07 8 125462 361 110463468
Gestational hypertension 16.02 11.07 16 125454 2218 110461611
Alveolitis necrotising 15.99 11.07 4 125466 20 110463809
Poisoning deliberate 15.94 11.07 5 125465 26326 110437503
Gastric disorder 15.92 11.07 9 125461 33348 110430481
Vascular device infection 15.90 11.07 48 125422 16464 110447365
Hepatic cirrhosis 15.89 11.07 33 125437 67593 110396236
Hepatic function abnormal 15.84 11.07 163 125307 89132 110374697
Activated partial thromboplastin time abnormal 15.84 11.07 8 125462 370 110463459
Drug withdrawal syndrome 15.81 11.07 12 125458 38042 110425787
Diabetes mellitus inadequate control 15.77 11.07 7 125463 29768 110434061
Pulmonary hypertension 15.72 11.07 112 125358 55108 110408721
Benign prostatic hyperplasia 15.71 11.07 51 125419 18183 110445646
Cardiovascular insufficiency 15.66 11.07 19 125451 3269 110460560
Facial discomfort 15.66 11.07 8 125462 379 110463450
Dehydration 15.64 11.07 223 125247 279288 110184541
Page kidney 15.59 11.07 5 125465 68 110463761
Cerebral amyloid angiopathy 15.57 11.07 9 125461 546 110463283
Blood pressure diastolic abnormal 15.45 11.07 5 125465 25810 110438019
Pseudohypoaldosteronism 15.39 11.07 5 125465 71 110463758
Haematidrosis 15.39 11.07 5 125465 71 110463758
Delusion 15.32 11.07 4 125466 23751 110440078
Uveitis 15.32 11.07 3 125467 21707 110442122
Agitation 15.29 11.07 71 125399 112980 110350849
Hand amputation 15.27 11.07 3 125467 3 110463826
Traumatic haemothorax 15.23 11.07 10 125460 762 110463067
Product dose omission issue 15.22 11.07 265 125205 321517 110142312
Foetal growth restriction 15.14 11.07 18 125452 3032 110460797
Diabetes mellitus 15.14 11.07 176 125294 99205 110364624
Palpitations 15.12 11.07 112 125358 159100 110304729
Anticoagulant therapy 15.03 11.07 24 125446 5337 110458492
Oedema 14.97 11.07 159 125311 209817 110254012
Dry skin 14.92 11.07 67 125403 107586 110356243
Blood thrombin increased 14.81 11.07 3 125467 4 110463825
Injection site bruising 14.78 11.07 22 125448 51241 110412588
Chronic sinusitis 14.77 11.07 5 125465 25079 110438750
Hypertensive nephropathy 14.76 11.07 11 125459 1027 110462802
Thrombolysis 14.76 11.07 7 125463 282 110463547
Febrile neutropenia 14.75 11.07 467 125003 316300 110147529
Tracheal haemorrhage 14.75 11.07 10 125460 804 110463025
Food interaction 14.67 11.07 15 125455 2137 110461692
Toxic skin eruption 14.64 11.07 66 125404 27449 110436380
Embolism arterial 14.61 11.07 14 125456 1845 110461984
Blood pressure systolic abnormal 14.55 11.07 5 125465 24845 110438984
Nausea 14.54 11.07 1206 124264 1234484 109229345
Subclavian vein thrombosis 14.54 11.07 17 125453 2815 110461014
Mania 14.41 11.07 3 125467 20793 110443036
Air embolism 14.38 11.07 9 125461 631 110463198
Lumbar puncture 14.37 11.07 7 125463 299 110463530
Fasciotomy 14.35 11.07 5 125465 89 110463740
Injection site mass 14.33 11.07 5 125465 24608 110439221
Irritability 14.29 11.07 20 125450 47789 110416040
Immune effector cell-associated neurotoxicity syndrome 14.26 11.07 43 125427 14739 110449090
Oesophageal injury 14.22 11.07 7 125463 306 110463523
Anastomotic leak 14.22 11.07 12 125458 1340 110462489
Haemobilia 14.22 11.07 9 125461 644 110463185
Pseudomonas infection 14.21 11.07 66 125404 27787 110436042
Renal cyst ruptured 14.19 11.07 5 125465 92 110463737
Cholestatic liver injury 14.19 11.07 28 125442 7348 110456481
Hallucination 14.13 11.07 63 125407 101369 110362460
Middle insomnia 14.12 11.07 3 125467 20499 110443330
Mitral perforation 14.06 11.07 4 125466 35 110463794
Cerebellar embolism 14.06 11.07 3 125467 6 110463823
Resuscitation 14.05 11.07 17 125453 2916 110460913
Complications of transplanted kidney 14.01 11.07 28 125442 7414 110456415
Paranoia 14.00 11.07 4 125466 22370 110441459
Graft haemorrhage 13.99 11.07 5 125465 96 110463733
Procalcitonin increased 13.99 11.07 20 125450 4036 110459793
Dysphonia 13.98 11.07 42 125428 75887 110387942
Urethral fistula 13.96 11.07 4 125466 36 110463793
Pituitary haemorrhage 13.95 11.07 7 125463 319 110463510
Nodule 13.94 11.07 10 125460 32621 110431208
Rheumatoid nodule 13.91 11.07 3 125467 20293 110443536
Incarcerated inguinal hernia 13.91 11.07 7 125463 321 110463508
Breast haematoma 13.85 11.07 6 125464 195 110463634
Delirium 13.79 11.07 93 125377 134932 110328897
Necrosis 13.78 11.07 36 125434 11370 110452459
Cardiac failure acute 13.75 11.07 59 125411 24019 110439810
Transmission of an infectious agent via product 13.73 11.07 6 125464 199 110463630
Ruptured cerebral aneurysm 13.71 11.07 9 125461 685 110463144
Inferior vena caval occlusion 13.67 11.07 5 125465 103 110463726
Mucosal haemorrhage 13.66 11.07 17 125453 3003 110460826
Intestinal infarction 13.64 11.07 12 125458 1418 110462411
Miosis 13.62 11.07 4 125466 21979 110441850
Ecchymosis 13.61 11.07 47 125423 17291 110446538
Implant site haematoma 13.57 11.07 6 125464 205 110463624
Blood cholesterol increased 13.55 11.07 139 125331 184646 110279183
Dermatitis atopic 13.53 11.07 6 125464 25535 110438294
Myelosuppression 13.51 11.07 58 125412 94282 110369547
Factor VIII inhibition 13.48 11.07 7 125463 343 110463486
Infusion site pain 13.48 11.07 47 125423 17372 110446457
Blood pressure increased 13.46 11.07 209 125261 258164 110205665
Stress cardiomyopathy 13.43 11.07 44 125426 15762 110448067
Embolism venous 13.42 11.07 22 125448 5001 110458828
Urea renal clearance decreased 13.41 11.07 4 125466 42 110463787
Acne 13.39 11.07 11 125459 33509 110430320
Hypergastrinaemia 13.37 11.07 7 125463 349 110463480
Medical device site haematoma 13.32 11.07 4 125466 43 110463786
Carotid intima-media thickness increased 13.32 11.07 5 125465 111 110463718
Sinus arrest 13.30 11.07 20 125450 4222 110459607
Budd-Chiari syndrome 13.28 11.07 5 125465 112 110463717
Pneumonia bacterial 13.23 11.07 62 125408 26199 110437630
Protein S increased 13.20 11.07 3 125467 9 110463820
Depressed mood 13.20 11.07 31 125439 60778 110403051
Hospitalisation 13.17 11.07 101 125369 142392 110321437
Cough 13.17 11.07 411 125059 461230 110002599
Pneumonia escherichia 13.15 11.07 11 125459 1213 110462616
Sleep disorder 13.13 11.07 153 125317 198491 110265338
Fear 13.01 11.07 5 125465 23188 110440641
Vascular parkinsonism 12.99 11.07 5 125465 119 110463710
Central venous catheter removal 12.99 11.07 8 125462 545 110463284
Brain stem infarction 12.99 11.07 14 125456 2120 110461709
Haemostasis 12.95 11.07 8 125462 548 110463281
Splenic vein thrombosis 12.94 11.07 10 125460 985 110462844
Atheroembolism 12.93 11.07 7 125463 374 110463455
Contrast encephalopathy 12.91 11.07 7 125463 375 110463454
Immunodeficiency 12.90 11.07 15 125455 38823 110425006
Fluid retention 12.89 11.07 59 125411 94248 110369581
Hypoxic-ischaemic encephalopathy 12.89 11.07 30 125440 8817 110455012
Rhabdomyolysis 12.87 11.07 200 125270 120201 110343628
Hypertriglyceridaemia 12.87 11.07 44 125426 16110 110447719
Bronchitis 12.84 11.07 115 125355 156917 110306912
Thrombophlebitis migrans 12.82 11.07 9 125461 765 110463064
Aphthous ulcer 12.82 11.07 4 125466 21132 110442697
Breath sounds abnormal 12.82 11.07 60 125410 25344 110438485
Drug-device interaction 12.80 11.07 5 125465 124 110463705
Eye pruritus 12.79 11.07 11 125459 32764 110431065
Cardiovascular deconditioning 12.78 11.07 4 125466 50 110463779
Myiasis 12.78 11.07 4 125466 50 110463779
Hypertransaminasaemia 12.77 11.07 58 125412 24197 110439632
Subdural haemorrhage 12.74 11.07 25 125445 6533 110457296
Cardiac murmur 12.71 11.07 6 125464 24622 110439207
Joint dislocation 12.71 11.07 12 125458 34178 110429651
Platelet aggregation test 12.70 11.07 4 125466 51 110463778
Maternal exposure timing unspecified 12.70 11.07 4 125466 21009 110442820
Breast cancer 12.68 11.07 15 125455 38527 110425302
Haematoma evacuation 12.67 11.07 7 125463 389 110463440
Medication error 12.63 11.07 69 125401 105297 110358532
Lipoedema 12.62 11.07 6 125464 243 110463586
Premature baby 12.61 11.07 21 125449 4834 110458995
Liver disorder 12.60 11.07 102 125368 142141 110321688
Alanine aminotransferase decreased 12.58 11.07 13 125457 1875 110461954
Basal ganglia haemorrhage 12.58 11.07 13 125457 1875 110461954
Platelet aggregation abnormal 12.56 11.07 4 125466 53 110463776
Body temperature decreased 12.56 11.07 14 125456 36921 110426908
Agranulocytosis 12.55 11.07 116 125354 61644 110402185
Blood creatine increased 12.55 11.07 35 125435 11486 110452343
Drug resistance 12.55 11.07 108 125362 56266 110407563
Lip swelling 12.53 11.07 24 125446 50643 110413186
Ergot poisoning 12.51 11.07 5 125465 132 110463697
Platelet disorder 12.50 11.07 18 125452 3657 110460172
Monoplegia 12.44 11.07 21 125449 4888 110458941
Type III immune complex mediated reaction 12.44 11.07 10 125460 1043 110462786
Nutritional condition abnormal 12.38 11.07 11 125459 1316 110462513
Capillary fragility increased 12.34 11.07 3 125467 13 110463816
Manufacturing materials issue 12.34 11.07 3 125467 13 110463816
Post procedural pulmonary embolism 12.33 11.07 6 125464 256 110463573
Spinal cord haemorrhage 12.30 11.07 8 125462 600 110463229
Paradoxical embolism 12.23 11.07 4 125466 58 110463771
Methaemoglobinaemia 12.18 11.07 30 125440 9138 110454691
Carotid artery dissection 12.18 11.07 7 125463 420 110463409
Urine glucose/creatinine ratio increased 12.17 11.07 5 125465 142 110463687
Leukocyturia 12.13 11.07 14 125456 2286 110461543
Product contamination microbial 12.11 11.07 10 125460 1084 110462745
Infusion site haemorrhage 12.10 11.07 20 125450 4578 110459251
Coronary artery reocclusion 12.07 11.07 5 125465 145 110463684
Bladder cancer 12.02 11.07 4 125466 20288 110443541
Prostate cancer 12.02 11.07 15 125455 37626 110426203
Catheter site thrombosis 11.99 11.07 8 125462 626 110463203
Femur fracture 11.95 11.07 20 125450 44449 110419380
Human herpesvirus 6 infection reactivation 11.83 11.07 10 125460 1119 110462710
Craniectomy 11.83 11.07 3 125467 16 110463813
Thoracic haemorrhage 11.83 11.07 6 125464 280 110463549
Dysstasia 11.78 11.07 12 125458 32974 110430855
Peripheral embolism 11.78 11.07 13 125457 2022 110461807
Heart rate decreased 11.77 11.07 51 125419 82705 110381124
Penile necrosis 11.76 11.07 4 125466 66 110463763
Extraocular muscle disorder 11.75 11.07 7 125463 449 110463380
Traumatic liver injury 11.74 11.07 8 125462 648 110463181
Uterine haemorrhage 11.72 11.07 17 125453 3477 110460352
Myocardial rupture 11.69 11.07 6 125464 287 110463542
Aspartate aminotransferase decreased 11.69 11.07 11 125459 1417 110462412
Kidney transplant rejection 11.69 11.07 35 125435 11952 110451877
Laboratory test abnormal 11.68 11.07 20 125450 44059 110419770
Abortion early 11.68 11.07 3 125467 17 110463812
Nonreassuring foetal heart rate pattern 11.68 11.07 3 125467 17 110463812
Superior sagittal sinus thrombosis 11.65 11.07 10 125460 1143 110462686
Platelet toxicity 11.53 11.07 3 125467 18 110463811
Epidermolysis 11.46 11.07 10 125460 1168 110462661
Therapeutic response shortened 11.46 11.07 10 125460 29573 110434256
Tuberculosis 11.45 11.07 3 125467 17771 110446058
Palmar-plantar erythrodysaesthesia syndrome 11.45 11.07 18 125452 41007 110422822
Nervousness 11.44 11.07 15 125455 36836 110426993
May-Thurner syndrome 11.44 11.07 4 125466 72 110463757
Nasal congestion 11.44 11.07 65 125405 98217 110365612
Multiple sclerosis relapse 11.40 11.07 25 125445 50215 110413614
Tooth disorder 11.40 11.07 10 125460 29499 110434330
Eschar 11.35 11.07 11 125459 1470 110462359
Out of specification test results 11.33 11.07 5 125465 170 110463659
Reperfusion arrhythmia 11.30 11.07 6 125464 308 110463521
Bloody peritoneal effluent 11.25 11.07 5 125465 173 110463656
Haemoglobin increased 11.18 11.07 29 125441 9118 110454711
Limbal swelling 11.13 11.07 3 125467 21 110463808
Rhinocerebral mucormycosis 11.13 11.07 11 125459 1506 110462323
Supraventricular tachycardia 11.11 11.07 56 125414 24366 110439463

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pulmonary haemorrhage 35.35 28.38 16 196 360 113381

Pharmacologic Action:

SourceCodeDescription
ATC B01AB01 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Heparin group
ATC B01AB51 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Heparin group
ATC C05BA03 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
ANTIVARICOSE THERAPY
Heparins or heparinoids for topical use
ATC C05BA53 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
ANTIVARICOSE THERAPY
Heparins or heparinoids for topical use
ATC S01XA14 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA CS M0010187 Heparin
FDA EPC N0000175474 Unfractionated Heparin
MeSH PA D000925 Anticoagulants
MeSH PA D002317 Cardiovascular Agents
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
FDA EPC N0000175980 Anti-coagulant
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:50249 anticoagulant
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

B01AB Heparin group 4 drugs
bemiparinenoxaparin sodiumnadroparin calciumsulodexide
C05BA Heparins or heparinoids for topical use 2 drugs
pentosan polysulfatesodium apolate
S01XA Other ophthalmologicals 24 drugs
acetylcysteinealteplasealumascorbic acidavacincaptad pegolcenegerminciclosporindexpanthenoldiquafosolethylmorphineguaiazuleninosine show all 24 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disseminated intravascular coagulation indication 67406007 DOID:11247
Deep venous thrombosis indication 128053003
Pulmonary thromboembolism indication 233935004
Peripheral arterial embolism indication 286959000
Non-Q wave myocardial infarction indication 314207007
Prevention of deep vein thrombosis indication 439993001
Prevention of catheter related bloodstream infection indication 736442006
Prevention of Ischemic Complications of Non-Q Wave MI indication
Peripheral Arterial Thromboembolism Prevention indication
Prevention of Recurrent Venous Thrombosis Associated with Malignancy indication
Pulmonary Thromboembolism Prevention indication
Deep Vein Thrombosis with Pulmonary Embolism indication
Maintain Patency of Indwelling Vascular Catheter indication
Prevention of Cardiac Ischemia in Unstable Angina indication
Myocardial infarction off-label use 22298006 DOID:5844
Coronavirus infection off-label use 186747009
Acute coronary syndrome off-label use 394659003
Percutaneous coronary intervention off-label use 415070008
Intracranial hemorrhage contraindication 1386000
Diabetic retinopathy contraindication 4855003 DOID:8947
Hypertensive retinopathy contraindication 6962006 DOID:11561
Retinal disorder contraindication 29555009 DOID:5679
Antithrombin III deficiency contraindication 36351005 DOID:3755
Gastrointestinal ulcer contraindication 40845000
Threatened abortion contraindication 54048003 DOID:9667
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Osteoporosis contraindication 64859006 DOID:11476
Operation on brain contraindication 70586009
Heparin-induced thrombocytopenia contraindication 73397007
Gastrointestinal hemorrhage contraindication 74474003
Ulceration of intestine contraindication 85942002
Acute gastric ulcer with hemorrhage contraindication 89748001
Hemophilia contraindication 90935002
Disorder of biliary tract contraindication 105997008 DOID:9741
Procedure on central nervous system contraindication 118679007
Bleeding contraindication 131148009
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Hemorrhagic cerebral infarction contraindication 230706003
Local anesthetic intrathecal block contraindication 231249005
Infective endocarditis contraindication 233850007
Procedure on spine contraindication 238181003
Qualitative platelet disorder contraindication 267532001
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral hemorrhage contraindication 274100004
Lumbar puncture contraindication 277762005
Bacterial endocarditis contraindication 301183007
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Dissection of aorta contraindication 308546005
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Surgical procedure on eye proper contraindication 373353005
Hypertensive urgency contraindication 443482000
Placement of Epidural Catheter contraindication
Spinal Epidural Hematoma contraindication
Thrombosis in Heparin Induced Thrombocytopenia contraindication
Indwelling Vascular Catheter contraindication
Significant Bleeding contraindication
Platelet Aggregation Inhibition contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
3,000 UNITS/3ML (1,000 UNITS/ML);40.5MG/3ML (13.5MG/ML) DEFENCATH CORMEDIX N214520 Nov. 15, 2023 RX SOLUTION N/A 7696182 May 16, 2026 A CATHETER LOCK SOLUTION TO REDUCE CATHETER-RELATED BLOODSTREAM INFECTIONS IN ADULT PATIENTS RECEIVING HEMODIALYSIS THROUGH A CENTRAL VENOUS CATHETER
5,000 UNITS/5ML (1,000 UNITS/ML);67.5MG/5ML (13.5MG/ML) DEFENCATH CORMEDIX N214520 Nov. 15, 2023 RX SOLUTION N/A 7696182 May 16, 2026 A CATHETER LOCK SOLUTION TO REDUCE CATHETER-RELATED BLOODSTREAM INFECTIONS IN ADULT PATIENTS RECEIVING HEMODIALYSIS THROUGH A CENTRAL VENOUS CATHETER

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
3,000 UNITS/3ML (1,000 UNITS/ML);40.5MG/3ML (13.5MG/ML) DEFENCATH CORMEDIX N214520 Nov. 15, 2023 RX SOLUTION N/A Nov. 15, 2028 NEW CHEMICAL ENTITY
5,000 UNITS/5ML (1,000 UNITS/ML);67.5MG/5ML (13.5MG/ML) DEFENCATH CORMEDIX N214520 Nov. 15, 2023 RX SOLUTION N/A Nov. 15, 2028 NEW CHEMICAL ENTITY
3,000 UNITS/3ML (1,000 UNITS/ML);40.5MG/3ML (13.5MG/ML) DEFENCATH CORMEDIX N214520 Nov. 15, 2023 RX SOLUTION N/A Nov. 15, 2033 GENERATING ANTIBIOTIC INCENTIVES NOW
5,000 UNITS/5ML (1,000 UNITS/ML);67.5MG/5ML (13.5MG/ML) DEFENCATH CORMEDIX N214520 Nov. 15, 2023 RX SOLUTION N/A Nov. 15, 2033 GENERATING ANTIBIOTIC INCENTIVES NOW

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Antithrombin-III Secreted ACTIVATOR Kd 7.85 IUPHAR CHEMBL
Spike glycoprotein Glycoprotein Kd 10.14 IUPHAR
Spike glycoprotein, S glycoprotein Glycoprotein Kd 6.30 IUPHAR

External reference:

IDSource
D02112 KEGG_DRUG
4017546 VANDF
4017547 VANDF
4017549 VANDF
4018538 VANDF
C0019134 UMLSCUI
CHEBI:24496 CHEBI
CHEMBL4650299 ChEMBL_ID
CHEMBL1201657 ChEMBL_ID
CHEMBL1201513 ChEMBL_ID
D006493 MESH_DESCRIPTOR_UI
DB01109 DRUGBANK_ID
4214 IUPHAR_LIGAND_ID
T2410KM04A UNII
20044 RXNORM
32703 MMSL
3649 MMSL
44090 MMSL
4821 MMSL
d00252 MMSL
002079 NDDF
002081 NDDF
015153 NDDF
29725000 SNOMEDCT_US
372877000 SNOMEDCT_US
412201008 SNOMEDCT_US
412401006 SNOMEDCT_US
50045009 SNOMEDCT_US
784398008 SNOMEDCT_US
84812008 SNOMEDCT_US
M7J PDB_CHEM_ID
37270-89-6 SECONDARY_CAS_RN
92044406 PUBCHEM_CID
392 INN_ID
T2410KM04A INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0043 INJECTION 1000 [USPU] INTRAVENOUS NDA 27 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0058 INJECTION 1000 [USPU] INTRAVENOUS NDA 27 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0059 INJECTION 5000 [USPU] INTRAVENOUS NDA 27 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0062 INJECTION 10000 [USPU] INTRAVENOUS NDA 27 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0137 INJECTION 1000 [USPU] INTRAVENOUS NDA 27 sections
Heparin Sodium in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-3301 INJECTION 5000 [USPU] INTRAVENOUS NDA 23 sections
Heparin Sodium in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-3462 INJECTION 10000 [USPU] INTRAVENOUS NDA 23 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9567 INJECTION 4000 [USPU] INTRAVENOUS NDA 19 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9577 INJECTION 5000 [USPU] INTRAVENOUS NDA 19 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9587 INJECTION 10000 [USPU] INTRAVENOUS NDA 19 sections
Heparin Sodium in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-9872 INJECTION 200 [USPU] INTRAVENOUS NDA 23 sections
HEPARIN SODIUM IN SODIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0424 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA 26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0428 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA 26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0431 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA 26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0433 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA 26 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0404-9872 INJECTION, SOLUTION 5000 [USPU] INTRAVENOUS ANDA 14 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0404-9872 INJECTION, SOLUTION 5000 [USPU] INTRAVENOUS ANDA 14 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0404-9979 INJECTION, SOLUTION 1000 [USPU] INTRAVENOUS NDA 16 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0404-9979 INJECTION, SOLUTION 1000 [USPU] INTRAVENOUS NDA 16 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-0012 INJECTION, SOLUTION 5000 [USPU] INTRAVENOUS NDA 26 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-1005 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA 27 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-1316 INJECTION, SOLUTION 10000 [USPU] SUBCUTANEOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-1402 INJECTION, SOLUTION 5000 [USPU] SUBCUTANEOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-2222 INJECTION, SOLUTION 200 [USPU] INTRAVENOUS NDA 27 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-2720 INJECTION, SOLUTION 1000 [USPU] SUBCUTANEOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-2721 INJECTION, SOLUTION 10000 [USPU] INTRAVENOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-2723 INJECTION, SOLUTION 5000 [USPU] SUBCUTANEOUS ANDA 25 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-3150 INJECTION, SOLUTION 5000 [USPU] INTRAVENOUS NDA 26 sections
Heparin Sodium and Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0409-4520 INJECTION, SOLUTION 10000 [USPU] INTRAVENOUS NDA 25 sections
Heparin Sodium and Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0409-4520 INJECTION, SOLUTION 10000 [USPU] INTRAVENOUS NDA 25 sections