heparin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
heparin derivatives including low molecular mass heparins	1358	9005-49-6

Description:

Molecule	Description
Synonyms: heparin heparin sodium heparin calcium	A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

heparin
heparin sodium
heparin calcium

A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
10	TU	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
Feb. 9, 1939	FDA	ORGANON USA INC

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heparin-induced thrombocytopenia	2813.58	11.50	676	53639	3906	63430801
Premature delivery	427.37	11.50	286	54029	29995	63404712
Shock haemorrhagic	255.82	11.50	138	54177	9757	63424950
Haemorrhage	239.62	11.50	278	54037	60744	63373963
Hereditary angioedema	234.12	11.50	119	54196	7443	63427264
Labelled drug-drug interaction medication error	212.01	11.50	136	54179	13263	63421444
Maternal exposure during pregnancy	211.05	11.50	533	53782	219529	63215178
Exposure during pregnancy	205.88	11.50	428	53887	155119	63279588
Thrombocytopenia	204.86	11.50	420	53895	150737	63283970
Vascular stent thrombosis	184.54	11.50	57	54258	920	63433787

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heparin-induced thrombocytopenia	3468.11	11.81	938	53466	4657	34897870
Vascular stent thrombosis	368.05	11.81	147	54257	2788	34899739
Thrombocytopenia	247.81	11.81	664	53740	155583	34746944
Cardiogenic shock	244.83	11.81	252	54152	26366	34876161
Haematoma	229.35	11.81	239	54165	25366	34877161
Multiple organ dysfunction syndrome	227.84	11.81	419	53985	76147	34826380
Labelled drug-drug interaction medication error	209.83	11.81	179	54225	14760	34887767
Appendicolith	204.53	11.81	141	54263	8460	34894067
Haemorrhage	200.14	11.81	317	54087	51053	34851474
Ventricular fibrillation	187.42	11.81	204	54200	22750	34879777

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heparin-induced thrombocytopenia	6087.45	10.78	1560	95400	8122	79639306
Vascular stent thrombosis	547.94	10.78	196	96764	3514	79643914
Thrombocytopenia	494.60	10.78	1033	95927	264226	79383202
Haemorrhage	408.14	10.78	528	96432	90590	79556838
Labelled drug-drug interaction medication error	390.59	10.78	300	96660	27350	79620078
Haematoma	382.13	10.78	390	96570	51805	79595623
Shock haemorrhagic	375.23	10.78	258	96702	19802	79627626
Multiple organ dysfunction syndrome	369.20	10.78	582	96378	119664	79527764
Cardiogenic shock	358.57	10.78	341	96619	41573	79605855
Premature delivery	347.74	10.78	262	96698	23205	79624223

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	B01AB01	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Heparin group
ATC	B01AB51	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Heparin group
ATC	C05BA03	CARDIOVASCULAR SYSTEM VASOPROTECTIVES ANTIVARICOSE THERAPY Heparins or heparinoids for topical use
ATC	C05BA53	CARDIOVASCULAR SYSTEM VASOPROTECTIVES ANTIVARICOSE THERAPY Heparins or heparinoids for topical use
ATC	S01XA14	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
CHEBI has role	CHEBI:50249	anticoagulants
FDA CS	M0010187	Heparin
FDA EPC	N0000175474	Unfractionated Heparin
FDA EPC	N0000175980	Anti-coagulant
MeSH PA	D000925	Anticoagulants

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Disseminated intravascular coagulation	indication	67406007	DOID:11247
Deep venous thrombosis	indication	128053003
Pulmonary thromboembolism	indication	233935004
Peripheral arterial embolism	indication	286959000
Non-Q wave myocardial infarction	indication	314207007
Prevention of deep vein thrombosis	indication	439993001
Deep Vein Thrombosis with Pulmonary Embolism	indication
Prevention of Recurrent Venous Thrombosis Associated with Malignancy	indication
Pulmonary Thromboembolism Prevention	indication
Peripheral Arterial Thromboembolism Prevention	indication

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Antithrombin-III	Secreted	P01008	ANT3_HUMAN	ACTIVATOR	Kd	7.85	IUPHAR	CHEMBL
Spike glycoprotein	Glycoprotein		SPIKE_SARS2		Kd	10.14	IUPHAR
Spike glycoprotein, S glycoprotein	Unclassified		SPIKE_SARS		Kd	6.30	IUPHAR

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External reference:

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ID	Source
002079	NDDF
002081	NDDF
015153	NDDF
20044	RXNORM
29725000	SNOMEDCT_US
32703	MMSL
3649	MMSL
37270-89-6	SECONDARY_CAS_RN
372877000	SNOMEDCT_US
392	INN_ID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0043	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0058	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0059	INJECTION	5000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0062	INJECTION	10000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0137	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0264-5705	INJECTION	5000 [USPU]	INTRAVENOUS	ANDA	20 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0264-5705	INJECTION	5000 [USPU]	INTRAVENOUS	ANDA	20 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9872	INJECTION, SOLUTION	5000 [USPU]	INTRAVENOUS	ANDA	14 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9872	INJECTION, SOLUTION	5000 [USPU]	INTRAVENOUS	ANDA	14 sections
HEPARIN SODIUM	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9873	INJECTION	10000 [USPU]	INTRAVENOUS	ANDA	14 sections

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