ascorbic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4072 50-81-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vitamin c
  • L-Ascorbic acid
  • ascorbic acid
  • ascorbic acid (vit C)
  • sodium ascorbate
  • calcium ascorbate
  • ascorbic acid, monosodium salt
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. NIH COVID-19 Treatment Guidelines Panel states that there are insufficient data to recommend either for or against use of ascorbic acid for the treatment of COVID-19 in critically or noncritically ill patients.
  • Molecular weight: 176.12
  • Formula: C6H8O6
  • CLOGP: -1.76
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 107.22
  • ALOGS: 0.14
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P
0.25 g V

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 0 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 333 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 25 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 567.77 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.35 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.05 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.26 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 11.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 884.30 9.88 71 368353 145849 46171789
Rheumatoid arthritis 825.58 9.88 3915 364509 236300 46081338
Pemphigus 710.56 9.88 1279 367145 43995 46273643
Systemic lupus erythematosus 586.07 9.88 1467 366957 63713 46253925
Toxicity to various agents 579.44 9.88 492 367932 211274 46106364
Glossodynia 476.06 9.88 1070 367354 43303 46274335
Pain 368.51 9.88 5537 362887 471411 45846227
Death 359.14 9.88 1398 367026 334150 45983488
Drug abuse 354.61 9.88 42 368382 63366 46254272
Hand deformity 345.72 9.88 811 367613 33763 46283875
Drug interaction 338.30 9.88 683 367741 202411 46115227
Arthropathy 303.45 9.88 1399 367025 83301 46234337
Alopecia 303.12 9.88 2257 366167 160157 46157481
Joint swelling 296.55 9.88 2284 366140 163789 46153849
Abdominal discomfort 295.43 9.88 2124 366300 149041 46168597
Maternal exposure during pregnancy 295.28 9.88 1592 366832 100957 46216681
Intentional overdose 287.92 9.88 78 368346 64866 46252772
Infusion related reaction 248.54 9.88 1506 366918 99702 46217936
Arthralgia 223.51 9.88 4078 364346 360525 45957113
Wound 211.68 9.88 781 367643 42021 46275617
Suicide attempt 207.60 9.88 87 368337 54949 46262689
Overdose 204.18 9.88 305 368119 101674 46215964
Cardiac arrest 180.35 9.88 271 368153 90128 46227510
Nasopharyngitis 180.09 9.88 1933 366491 152065 46165573
Exposure during pregnancy 174.26 9.88 1454 366970 106758 46210880
Drug hypersensitivity 168.41 9.88 1179 367245 242646 46074992
Contraindicated product administered 165.12 9.88 1139 367285 78808 46238830
Febrile neutropenia 161.84 9.88 313 368111 94314 46223324
Acute kidney injury 159.20 9.88 1148 367276 234707 46082931
Anti-cyclic citrullinated peptide antibody positive 157.54 9.88 417 368007 18728 46298910
Synovitis 155.71 9.88 918 367506 60157 46257481
Pericarditis 141.20 9.88 463 367961 23464 46294174
Hip arthroplasty 140.49 9.88 386 368038 17726 46299912
Swelling 133.66 9.88 1537 366887 122974 46194664
Rheumatoid factor positive 130.82 9.88 407 368017 20054 46297584
Knee arthroplasty 123.06 9.88 439 367985 23226 46294412
Cardiac failure 121.19 9.88 283 368141 79665 46237973
Lactic acidosis 119.45 9.88 59 368365 33850 46283788
Sinusitis 115.22 9.88 1546 366878 128222 46189416
Device expulsion 113.12 9.88 38 368386 27504 46290134
Red blood cell sedimentation rate abnormal 110.99 9.88 296 368128 13353 46304285
Depressed level of consciousness 107.62 9.88 130 368294 47439 46270199
Injection site erythema 107.21 9.88 976 367448 73451 46244187
Sickle cell anaemia with crisis 104.85 9.88 143 368281 3849 46313789
Cardio-respiratory arrest 101.50 9.88 199 368225 59670 46257968
Discomfort 100.54 9.88 672 367752 45998 46271640
Neutropenia 99.44 9.88 691 367733 142513 46175125
Immunodeficiency 99.36 9.88 277 368147 12829 46304809
Drug reaction with eosinophilia and systemic symptoms 98.78 9.88 55 368369 29493 46288145
C-reactive protein abnormal 98.41 9.88 380 368044 20890 46296748
Respiratory arrest 97.99 9.88 74 368350 33742 46283896
Sopor 97.44 9.88 19 368405 19809 46297829
Pregnancy 94.69 9.88 445 367979 26692 46290946
Malignant neoplasm progression 94.30 9.88 235 368189 64691 46252947
Lower respiratory tract infection 93.87 9.88 750 367674 54339 46263299
Product use issue 93.45 9.88 1150 367274 93494 46224144
Intentional self-injury 93.07 9.88 37 368387 24129 46293509
Electrocardiogram QT prolonged 91.94 9.88 165 368259 51160 46266478
Fatigue 90.17 9.88 5757 362667 602940 45714698
Musculoskeletal stiffness 89.24 9.88 1173 367251 96820 46220818
Arthritis 89.09 9.88 968 367456 76348 46241290
Confusional state 86.51 9.88 825 367599 159067 46158571
Rhabdomyolysis 86.12 9.88 123 368301 41786 46275852
Injection site pain 85.97 9.88 1254 367170 105898 46211740
Bradycardia 84.31 9.88 256 368168 66042 46251596
Renal failure 83.92 9.88 538 367886 113056 46204582
Osteoarthritis 83.62 9.88 802 367622 61223 46256415
Hyponatraemia 81.63 9.88 467 367957 100865 46216773
Injection site pruritus 77.78 9.88 559 367865 39184 46278454
Disease progression 75.58 9.88 417 368007 90883 46226755
Blood pressure fluctuation 74.58 9.88 453 367971 29995 46287643
Femur fracture 72.76 9.88 521 367903 36476 46281162
Injection site reaction 72.76 9.88 635 367789 47214 46270424
Dyspnoea 72.44 9.88 3329 365095 512219 45805419
Injection site swelling 70.32 9.88 552 367872 39775 46277863
Bursitis 69.68 9.88 326 368098 19516 46298122
Abortion spontaneous 68.34 9.88 583 367841 43063 46274575
Psoriatic arthropathy 67.93 9.88 506 367918 35873 46281765
Temperature regulation disorder 67.41 9.88 106 368318 3254 46314384
Agitation 66.92 9.88 219 368205 55196 46262442
Hypoglycaemia 66.88 9.88 213 368211 54136 46263502
Hepatocellular injury 66.43 9.88 81 368343 29441 46288197
Drug dependence 65.15 9.88 38 368386 19863 46297775
Hepatic enzyme increased 64.73 9.88 955 367469 80832 46236806
Hypotension 63.89 9.88 1374 367050 231215 46086423
Basal cell carcinoma 63.64 9.88 325 368099 20162 46297476
Tachycardia 63.22 9.88 493 367931 99129 46218509
Peripheral swelling 62.27 9.88 1661 366763 156410 46161228
Poisoning 61.64 9.88 17 368407 13977 46303661
Cholestasis 61.35 9.88 73 368351 26820 46290818
Metabolic acidosis 60.59 9.88 135 368289 38645 46278993
Cytomegalovirus infection 60.32 9.88 34 368390 18110 46299528
Product quality issue 59.11 9.88 120 368304 35528 46282110
Disability assessment scale score increased 57.18 9.88 79 368345 2153 46315485
Serotonin syndrome 57.13 9.88 64 368360 24156 46293482
Hepatic failure 56.69 9.88 111 368313 33305 46284333
General physical health deterioration 56.52 9.88 612 367812 115157 46202481
Duodenal ulcer perforation 56.09 9.88 171 368253 8331 46309307
Osteoporosis 55.67 9.88 527 367897 40081 46277557
Joint effusion 55.24 9.88 214 368210 11781 46305857
Delirium 54.63 9.88 134 368290 37094 46280544
Renal impairment 54.52 9.88 353 368071 74019 46243619
Drug resistance 52.95 9.88 36 368388 17332 46300306
Helicobacter infection 52.12 9.88 207 368217 11529 46306109
Impaired healing 51.95 9.88 480 367944 36263 46281375
Drug withdrawal syndrome 51.81 9.88 85 368339 27299 46290339
Pulmonary arterial hypertension 51.41 9.88 78 368346 25850 46291788
Multiple organ dysfunction syndrome 50.97 9.88 222 368202 51488 46266150
Product use in unapproved indication 50.40 9.88 462 367962 89811 46227827
Therapeutic product effect decreased 48.94 9.88 920 367504 81681 46235957
Intentional product misuse 47.88 9.88 200 368224 46928 46270710
Encephalopathy 47.66 9.88 123 368301 33466 46284172
Poisoning deliberate 47.55 9.88 4 368420 7922 46309716
Pain in extremity 47.52 9.88 2496 365928 256184 46061454
Tremor 47.40 9.88 635 367789 115004 46202634
Disorientation 47.32 9.88 142 368282 36776 46280862
Coma 46.92 9.88 269 368155 58080 46259558
Caesarean section 46.51 9.88 256 368168 16347 46301291
Joint laxity 46.10 9.88 69 368355 2027 46315611
Sedation 45.35 9.88 69 368355 22841 46294797
Anaphylactic reaction 44.81 9.88 241 368183 52871 46264767
Psoriasis 44.70 9.88 870 367554 77734 46239904
Hepatic function abnormal 44.40 9.88 132 368292 34289 46283349
Hyperglycaemia 44.16 9.88 136 368288 34935 46282703
Upper respiratory tract infection 44.13 9.88 726 367698 62830 46254808
Respiratory failure 43.60 9.88 508 367916 94308 46223330
Maternal drugs affecting foetus 43.19 9.88 118 368306 5400 46312238
Thrombocytopenia 42.95 9.88 721 367703 125860 46191778
Hyperkalaemia 42.83 9.88 230 368194 50479 46267159
Mydriasis 42.57 9.88 15 368409 10538 46307100
Diabetic ketoacidosis 42.00 9.88 49 368375 18161 46299477
Blood pressure diastolic abnormal 41.91 9.88 127 368297 6167 46311471
Injection site bruising 41.87 9.88 448 367976 35188 46282450
Hypothermia 41.71 9.88 22 368402 12161 46305477
Hypoxia 41.67 9.88 239 368185 51599 46266039
Night sweats 41.60 9.88 362 368062 26888 46290750
Body temperature increased 41.53 9.88 337 368087 24524 46293114
Syncope 40.97 9.88 581 367843 104222 46213416
Food allergy 40.75 9.88 134 368290 6799 46310839
Extrapyramidal disorder 40.61 9.88 19 368405 11249 46306389
Palmar-plantar erythrodysaesthesia syndrome 40.09 9.88 62 368362 20389 46297249
Torsade de pointes 40.08 9.88 23 368401 12131 46305507
Oropharyngeal pain 39.86 9.88 814 367610 73354 46244284
Seizure 39.79 9.88 707 367717 122347 46195291
Hallucination 39.78 9.88 231 368193 49720 46267918
Nausea 39.14 9.88 4791 363633 682663 45634975
Osteonecrosis of jaw 38.79 9.88 140 368284 34262 46283376
Live birth 38.71 9.88 173 368251 10157 46307481
Schizophrenia 38.51 9.88 10 368414 8558 46309080
Localised infection 38.35 9.88 320 368104 23481 46294157
Weight increased 38.05 9.88 1624 366800 162849 46154789
Injection site rash 37.92 9.88 234 368190 15579 46302059
Neck deformity 37.90 9.88 59 368365 1795 46315843
No adverse event 37.49 9.88 141 368283 34090 46283548
Pre-eclampsia 37.12 9.88 143 368281 7851 46309787
Acute hepatic failure 36.85 9.88 37 368387 14684 46302954
Altered state of consciousness 36.70 9.88 81 368343 23267 46294371
Shock 36.68 9.88 73 368351 21772 46295866
Ejection fraction decreased 36.50 9.88 53 368371 17884 46299754
Leukopenia 36.33 9.88 354 368070 67989 46249649
Foot deformity 35.58 9.88 226 368198 15199 46302439
Anxiety 35.55 9.88 1129 367295 180828 46136810
Somnolence 35.38 9.88 952 367472 155569 46162069
Gamma-glutamyltransferase increased 35.24 9.88 130 368294 31610 46286028
Oral herpes 35.23 9.88 268 368156 19122 46298516
Gestational diabetes 35.06 9.88 131 368293 7088 46310550
Disseminated intravascular coagulation 35.02 9.88 60 368364 18945 46298693
Abnormal behaviour 34.81 9.88 71 368353 20987 46296651
Loss of personal independence in daily activities 34.59 9.88 639 367785 56544 46261094
Blood creatine phosphokinase increased 34.56 9.88 108 368316 27616 46290022
Premature labour 34.23 9.88 178 368246 11121 46306517
Ear pain 34.00 9.88 294 368130 21798 46295840
Coeliac disease 33.99 9.88 129 368295 7032 46310606
Influenza 33.96 9.88 934 367490 88336 46229302
Suicidal ideation 33.92 9.88 283 368141 56099 46261539
Psychotic disorder 33.52 9.88 81 368343 22540 46295098
Contusion 33.18 9.88 915 367509 86572 46231066
Juvenile idiopathic arthritis 32.98 9.88 89 368335 4043 46313595
Red blood cell sedimentation rate increased 32.85 9.88 300 368124 22589 46295049
Bronchitis 32.82 9.88 1081 367343 104898 46212740
Off label use 32.77 9.88 2567 365857 377274 45940364
Neuroleptic malignant syndrome 32.66 9.88 24 368400 11098 46306540
Limb deformity 32.63 9.88 81 368343 3495 46314143
Muscle spasticity 32.45 9.88 177 368247 11263 46306375
Metastases to bone 32.36 9.88 55 368369 17421 46300217
Rheumatoid nodule 32.26 9.88 149 368275 8871 46308767
Anaphylactic shock 32.14 9.88 70 368354 20204 46297434
Herpes zoster 32.01 9.88 731 367693 67141 46250497
Blood pressure systolic abnormal 31.86 9.88 106 368318 5411 46312227
Metastases to liver 31.56 9.88 67 368357 19518 46298120
Loss of consciousness 31.55 9.88 633 367791 107605 46210033
Dizziness 31.34 9.88 2288 366136 338126 45979512
Cellulitis 30.99 9.88 750 367674 69538 46248100
Drug level increased 30.64 9.88 62 368362 18379 46299259
Blood bilirubin increased 30.59 9.88 152 368272 34032 46283606
Transplant rejection 30.46 9.88 19 368405 9577 46308061
Multiple fractures 30.43 9.88 105 368319 5462 46312176
Therapeutic response decreased 30.37 9.88 494 367930 42651 46274987
Ventricular tachycardia 29.97 9.88 55 368369 16912 46300726
Cystitis 29.86 9.88 484 367940 41757 46275881
Carpal tunnel syndrome 29.83 9.88 221 368203 15638 46302000
Pyrexia 29.64 9.88 2360 366064 346442 45971196
Akathisia 29.39 9.88 12 368412 7702 46309936
Grip strength decreased 29.20 9.88 140 368284 8466 46309172
Intramedullary rod insertion 29.17 9.88 57 368367 2086 46315552
Nodule 29.09 9.88 217 368207 15388 46302250
Cardiac failure congestive 29.06 9.88 529 367895 91221 46226417
Toxic skin eruption 28.92 9.88 33 368391 12354 46305284
Posterior reversible encephalopathy syndrome 28.64 9.88 47 368377 15094 46302544
Arthritis infective 28.44 9.88 97 368327 5016 46312622
Neurotoxicity 28.43 9.88 40 368384 13677 46303961
Inappropriate antidiuretic hormone secretion 28.37 9.88 42 368382 14060 46303578
Skin cancer 28.13 9.88 141 368283 8682 46308956
Accidental overdose 28.07 9.88 74 368350 19992 46297646
Agranulocytosis 27.95 9.88 86 368338 22099 46295539
Hypokalaemia 27.73 9.88 508 367916 87516 46230122
Angioedema 27.68 9.88 189 368235 39153 46278485
Hypersensitivity 27.66 9.88 1451 366973 148870 46168768
Premature delivery 27.60 9.88 281 368143 21788 46295850
Ventricular septal defect 27.42 9.88 82 368342 3952 46313686
Smear cervix abnormal 27.33 9.88 61 368363 2455 46315183
Febrile bone marrow aplasia 27.26 9.88 10 368414 6852 46310786
Vomiting 27.26 9.88 3143 365281 449651 45867987
Blood creatinine increased 26.95 9.88 432 367992 75971 46241667
Malignant melanoma 26.82 9.88 155 368269 10079 46307559
Small for dates baby 26.71 9.88 76 368348 3561 46314077
Acute generalised exanthematous pustulosis 26.71 9.88 21 368403 9384 46308254
Aggression 26.69 9.88 91 368333 22653 46294985
Fibromyalgia 26.60 9.88 420 368004 36043 46281595
Unresponsive to stimuli 26.58 9.88 147 368277 32027 46285611
Heart rate decreased 26.50 9.88 374 368050 31349 46286289
Blood pressure diastolic increased 26.23 9.88 105 368319 5869 46311769
Blood pressure diastolic decreased 26.15 9.88 197 368227 14014 46303624
Injection site warmth 25.95 9.88 192 368232 13580 46304058
Respiratory depression 25.91 9.88 32 368392 11568 46306070
Anaemia 25.85 9.88 1705 366719 254074 46063564
Mental status changes 25.80 9.88 185 368239 37903 46279735
Disturbance in attention 25.63 9.88 145 368279 31415 46286223
Myocardial infarction 25.61 9.88 580 367844 96948 46220690
Thrombotic microangiopathy 25.61 9.88 17 368407 8289 46309349
Neck mass 25.35 9.88 70 368354 3223 46314415
Foetal exposure during pregnancy 25.08 9.88 361 368063 30386 46287252
Developmental hip dysplasia 25.08 9.88 40 368384 1243 46316395
Dysarthria 24.99 9.88 183 368241 37315 46280323
Bone marrow failure 24.81 9.88 135 368289 29534 46288104
Gastroenteritis viral 24.75 9.88 235 368189 17884 46299754
Tuberculosis 24.68 9.88 152 368272 10113 46307525
Dry eye 24.34 9.88 355 368069 29967 46287671
Surgery 24.30 9.88 340 368084 28445 46289193
Musculoskeletal pain 24.25 9.88 725 367699 69403 46248235
Graft versus host disease 23.91 9.88 11 368413 6577 46311061
Ischaemic stroke 23.90 9.88 61 368363 16661 46300977
Bone erosion 23.44 9.88 141 368283 9302 46308336
Skin ulcer 23.35 9.88 373 368051 32085 46285553
Status epilepticus 23.22 9.88 47 368377 13932 46303706
Rash 23.22 9.88 3181 365243 353331 45964307
Joint stiffness 23.21 9.88 321 368103 26787 46290851
Synovial cyst 23.14 9.88 117 368307 7229 46310409
Mania 23.11 9.88 31 368393 10815 46306823
Polyneuropathy 23.11 9.88 35 368389 11609 46306029
Acute myeloid leukaemia 22.98 9.88 57 368367 15721 46301917
Premature rupture of membranes 22.94 9.88 82 368342 4341 46313297
Face oedema 22.90 9.88 76 368348 19077 46298561
Multiple sclerosis relapse 22.89 9.88 217 368207 41908 46275730
Enthesopathy 22.69 9.88 85 368339 4605 46313033
Cyst 22.41 9.88 168 368256 11932 46305706
Weight decreased 22.15 9.88 1942 366482 208907 46108731
Treatment failure 22.14 9.88 922 367502 92165 46225473
Tenosynovitis stenosans 22.01 9.88 48 368376 1901 46315737
Restlessness 21.98 9.88 115 368309 25409 46292229
Postoperative wound infection 21.92 9.88 131 368293 8622 46309016
Neuropathy peripheral 21.80 9.88 548 367876 90345 46227293
Dyspnoea exertional 21.75 9.88 273 368151 50016 46267622
Acute graft versus host disease 21.72 9.88 3 368421 4027 46313611
Hallucination, auditory 21.67 9.88 32 368392 10724 46306914
Rash maculo-papular 21.61 9.88 130 368294 27744 46289894
Foot fracture 21.54 9.88 243 368181 19339 46298299
Joint destruction 21.51 9.88 63 368361 3001 46314637
Hiatus hernia 21.46 9.88 230 368194 18072 46299566
Drug-induced liver injury 21.45 9.88 115 368309 25253 46292385
Nightmare 21.15 9.88 64 368360 16534 46301104
Joint range of motion decreased 21.08 9.88 197 368227 14927 46302711
Cataract 21.05 9.88 488 367936 44927 46272711
Parkinsonism 21.03 9.88 19 368405 7929 46309709
Forced expiratory volume decreased 21.03 9.88 7 368417 5097 46312541
Neoplasm progression 20.92 9.88 124 368300 26559 46291079
Dyskinesia 20.83 9.88 138 368286 28787 46288851
Tachypnoea 20.78 9.88 52 368372 14299 46303339
Inflammation 20.75 9.88 518 367906 48263 46269375
Ear infection 20.72 9.88 275 368149 22738 46294900
Brain oedema 20.69 9.88 42 368382 12436 46305202
Respiratory distress 20.67 9.88 157 368267 31759 46285879
Diabetes mellitus inadequate control 20.64 9.88 46 368378 13168 46304470
Cerebral haemorrhage 20.61 9.88 135 368289 28236 46289402
Jaundice 20.58 9.88 138 368286 28707 46288931
Fracture delayed union 20.52 9.88 50 368374 2132 46315506
Aspartate aminotransferase increased 20.39 9.88 469 367955 78231 46239407
Impaired quality of life 20.27 9.88 64 368360 3178 46314460
Haemoglobin decreased 20.26 9.88 1227 367197 127722 46189916
Serum ferritin increased 20.19 9.88 89 368335 5194 46312444
Wheezing 20.14 9.88 298 368126 53088 46264550
Immune reconstitution inflammatory syndrome 20.10 9.88 10 368414 5715 46311923
Device dislocation 20.05 9.88 96 368328 21706 46295932
Hypomania 19.95 9.88 5 368419 4383 46313255
Obstructive airways disorder 19.89 9.88 48 368376 13364 46304274
Eosinophilia 19.86 9.88 81 368343 19136 46298502
Speech disorder 19.78 9.88 186 368238 35981 46281657
Skin papilloma 19.63 9.88 75 368349 4101 46313537
Myalgia 19.62 9.88 783 367641 122305 46195333
Latent tuberculosis 19.60 9.88 46 368378 1914 46315724
Swollen joint count increased 19.46 9.88 52 368372 2348 46315290
Squamous cell carcinoma 19.45 9.88 117 368307 7719 46309919
Blood pressure systolic increased 19.30 9.88 327 368097 28460 46289178
Pancreatitis acute 19.28 9.88 116 368308 24756 46292882
Tenderness 19.26 9.88 211 368213 16670 46300968
Device use error 19.20 9.88 8 368416 5073 46312565
Alanine aminotransferase increased 19.19 9.88 541 367883 87910 46229728
Blood pressure increased 19.11 9.88 1201 367223 125465 46192173
Bronchospasm 19.01 9.88 62 368362 15645 46301993
Polyhydramnios 19.01 9.88 46 368378 1953 46315685
Psychomotor hyperactivity 18.98 9.88 29 368395 9584 46308054
Cardiogenic shock 18.92 9.88 66 368358 16318 46301320
Fracture 18.85 9.88 206 368218 16265 46301373
Blood iron increased 18.85 9.88 36 368388 1295 46316343
Ventricular fibrillation 18.80 9.88 39 368385 11457 46306181
Laryngitis 18.78 9.88 132 368292 9184 46308454
Miosis 18.74 9.88 15 368409 6642 46310996
Oliguria 18.70 9.88 25 368399 8734 46308904
Placental disorder 18.60 9.88 37 368387 1372 46316266
Rheumatic fever 18.58 9.88 57 368367 2786 46314852
Low turnover osteopathy 18.52 9.88 75 368349 4214 46313424
Substance abuse 18.47 9.88 5 368419 4162 46313476
Rotator cuff repair 18.39 9.88 38 368386 1449 46316189
Transplant dysfunction 18.30 9.88 7 368417 4675 46312963
Blood alkaline phosphatase increased 18.28 9.88 212 368212 39397 46278241
Eye infection 18.24 9.88 129 368295 8994 46308644
Joint noise 18.20 9.88 61 368363 3126 46314512
Rhinorrhoea 18.20 9.88 499 367925 47166 46270472
Accidental exposure to product 18.14 9.88 95 368329 20986 46296652
Ascites 17.99 9.88 193 368231 36391 46281247
Joint injury 17.91 9.88 231 368193 18978 46298660
Stress cardiomyopathy 17.89 9.88 21 368403 7763 46309875
Blood glucose increased 17.86 9.88 432 367992 71581 46246057
Haematotoxicity 17.84 9.88 17 368407 6916 46310722
Myoclonus 17.82 9.88 56 368368 14296 46303342
Haemorrhage 17.80 9.88 315 368109 54554 46263084
Congenital arterial malformation 17.78 9.88 18 368406 349 46317289
Tardive dyskinesia 17.71 9.88 20 368404 7523 46310115
Breast feeding 17.68 9.88 28 368396 865 46316773
Asphyxia 17.67 9.88 10 368414 5316 46312322
Catatonia 17.67 9.88 4 368420 3758 46313880
Myocarditis 17.66 9.88 21 368403 7718 46309920
Injection site haematoma 17.63 9.88 95 368329 6017 46311621
Cerebral infarction 17.58 9.88 110 368314 23256 46294382
Metastases to central nervous system 17.57 9.88 39 368385 11182 46306456
Plasma cell myeloma 17.57 9.88 246 368178 44232 46273406
Erythema multiforme 17.55 9.88 31 368393 9673 46307965
Acute chest syndrome 17.42 9.88 22 368402 548 46317090
Lupus vasculitis 17.31 9.88 20 368404 453 46317185
Viral infection 17.29 9.88 335 368089 29900 46287738
Oedema 17.28 9.88 400 368024 66671 46250967
Bone density decreased 17.28 9.88 134 368290 9618 46308020
Hypocalcaemia 17.23 9.88 132 368292 26653 46290985
Second primary malignancy 17.11 9.88 16 368408 6568 46311070
Polyarthritis 17.09 9.88 99 368325 6443 46311195
Bone disorder 17.06 9.88 237 368187 19796 46297842
Ketoacidosis 17.06 9.88 5 368419 3950 46313688
Shock haemorrhagic 17.04 9.88 26 368398 8598 46309040
Haemorrhage intracranial 16.99 9.88 48 368376 12676 46304962
Muscle rigidity 16.97 9.88 33 368391 9928 46307710
Melaena 16.88 9.88 139 368285 27633 46290005
Pleural effusion 16.83 9.88 512 367912 82440 46235198
Uterine contractions during pregnancy 16.82 9.88 21 368403 517 46317121
Renal injury 16.79 9.88 31 368393 9510 46308128
Synovial fluid analysis 16.77 9.88 35 368389 1344 46316294
Loose body in joint 16.76 9.88 30 368394 1026 46316612
Foot operation 16.76 9.88 78 368346 4659 46312979
Immunosuppression 16.75 9.88 109 368315 7391 46310247
Body tinea 16.72 9.88 28 368396 907 46316731
Haemophagocytic lymphohistiocytosis 16.63 9.88 25 368399 8317 46309321
Pathogen resistance 16.63 9.88 14 368410 6046 46311592
Wrist fracture 16.62 9.88 151 368273 11352 46306286
Tooth infection 16.61 9.88 159 368265 12127 46305511
Knee operation 16.51 9.88 78 368346 4688 46312950
Pharyngitis streptococcal 16.50 9.88 119 368305 8349 46309289
Gallbladder polyp 16.46 9.88 25 368399 744 46316894
Wheelchair user 16.45 9.88 69 368355 3939 46313699
Arrhythmia 16.26 9.88 186 368238 34655 46282983
Clear cell renal cell carcinoma 16.24 9.88 29 368395 990 46316648
International normalised ratio increased 16.23 9.88 266 368158 46617 46271021
Epilepsy 16.22 9.88 115 368309 23623 46294015
Injection site irritation 16.21 9.88 72 368352 4215 46313423
Product administration error 16.21 9.88 90 368334 19591 46298047
Urinary tract infection 16.16 9.88 1980 366444 218286 46099352
Tumour lysis syndrome 16.12 9.88 20 368404 7216 46310422
Synovial disorder 16.12 9.88 26 368398 816 46316822
Anuria 16.10 9.88 42 368382 11389 46306249
Body height below normal 16.09 9.88 41 368383 1798 46315840
Metastases to lung 16.08 9.88 38 368386 10658 46306980
Pulmonary tuberculosis 16.08 9.88 77 368347 4654 46312984
Injection site haemorrhage 16.05 9.88 241 368183 20468 46297170
Device difficult to use 15.94 9.88 24 368400 7980 46309658
Cervical incompetence 15.88 9.88 22 368402 601 46317037
Gestational hypertension 15.80 9.88 45 368379 2110 46315528
Pemphigoid 15.80 9.88 13 368411 5678 46311960
Hallucination, visual 15.69 9.88 80 368344 17793 46299845
Cestode infection 15.62 9.88 15 368409 272 46317366
Blood pressure decreased 15.55 9.88 338 368086 56821 46260817
Neutrophil count decreased 15.49 9.88 245 368179 43181 46274457
Endodontic procedure 15.48 9.88 49 368375 2436 46315202
Disability 15.48 9.88 135 368289 10032 46307606
Cytomegalovirus viraemia 15.46 9.88 8 368416 4470 46313168
Complication of device insertion 15.40 9.88 10 368414 4934 46312704
Bronchopulmonary aspergillosis 15.40 9.88 22 368402 7474 46310164
Acute pulmonary oedema 15.39 9.88 24 368400 7867 46309771
Hemiparesis 15.34 9.88 94 368330 19975 46297663
Intervertebral disc degeneration 15.28 9.88 166 368258 13086 46304552
Exomphalos 15.21 9.88 20 368404 519 46317119
Cytokine release syndrome 15.17 9.88 16 368408 6207 46311431
Crystal nephropathy 15.15 9.88 25 368399 800 46316838
Coagulopathy 15.02 9.88 85 368339 18414 46299224
Hypomagnesaemia 14.98 9.88 108 368316 22102 46295536
Pulmonary hypertension 14.97 9.88 197 368227 35796 46281842
Deafness transitory 14.93 9.88 37 368387 1595 46316043
Stevens-Johnson syndrome 14.90 9.88 115 368309 23182 46294456
Withdrawal syndrome 14.90 9.88 83 368341 18051 46299587
Cyanosis 14.88 9.88 70 368354 15901 46301737
Limb injury 14.81 9.88 223 368201 18951 46298687
Atrial septal defect 14.74 9.88 93 368331 6239 46311399
Sinus tachycardia 14.74 9.88 105 368319 21544 46296094
Toxic epidermal necrolysis 14.71 9.88 109 368315 22169 46295469
Decreased appetite 14.55 9.88 1324 367100 192512 46125126
Aspergillus infection 14.37 9.88 20 368404 6870 46310768
Infective pulmonary exacerbation of cystic fibrosis 14.26 9.88 41 368383 10766 46306872
Induced labour 14.15 9.88 26 368398 908 46316730
Atrioventricular block complete 14.12 9.88 24 368400 7603 46310035
Bradyphrenia 14.11 9.88 17 368407 6213 46311425
Drug ineffective for unapproved indication 14.10 9.88 74 368350 16339 46301299
Gastrointestinal pain 14.09 9.88 104 368320 7351 46310287
Red blood cell count decreased 14.04 9.88 347 368077 32276 46285362
Pulmonary embolism 13.98 9.88 707 367717 107878 46209760
Injection site urticaria 13.85 9.88 150 368274 11817 46305821
Glycosylated haemoglobin increased 13.81 9.88 42 368382 10834 46306804
Asthma 13.80 9.88 586 367838 90956 46226682
Diverticulitis 13.80 9.88 350 368074 32689 46284949
Foetal death 13.79 9.88 117 368307 8626 46309012
Post procedural infection 13.74 9.88 104 368320 7409 46310229
Lymphadenectomy 13.64 9.88 25 368399 871 46316767
Laryngospasm 13.61 9.88 3 368421 2870 46314768
Gastrooesophageal reflux disease 13.53 9.88 717 367707 73627 46244011
Spinal stenosis 13.50 9.88 155 368269 12388 46305250
Back pain 13.50 9.88 1873 366551 208166 46109472
Wound infection 13.48 9.88 133 368291 10226 46307412
Chronic kidney disease 13.46 9.88 234 368190 40637 46277001
Scleritis 13.45 9.88 52 368372 2860 46314778
Pulmonary oedema 13.39 9.88 304 368120 50801 46266837
Pharyngitis 13.38 9.88 204 368220 17379 46300259
Osteopenia 13.38 9.88 198 368226 16763 46300875
Mouth ulceration 13.27 9.88 291 368133 26541 46291097
Inadequate analgesia 13.27 9.88 3 368421 2821 46314817
Cognitive disorder 13.18 9.88 208 368216 36675 46280963
Pain in jaw 13.18 9.88 218 368206 38154 46279484
Lung neoplasm malignant 13.09 9.88 183 368241 15306 46302332
Catheter management 13.07 9.88 3 368421 2792 46314846
Cholestasis of pregnancy 13.06 9.88 28 368396 1096 46316542
Maternal exposure during breast feeding 13.04 9.88 50 368374 2739 46314899
Condition aggravated 13.03 9.88 2162 366262 242890 46074748
Myopathy 13 9.88 32 368392 8849 46308789
Incoherent 12.91 9.88 10 368414 4502 46313136
Morning sickness 12.88 9.88 21 368403 665 46316973
Haematocrit decreased 12.82 9.88 365 368059 34692 46282946
Hyperuricaemia 12.82 9.88 11 368413 4706 46312932
Product prescribing error 12.80 9.88 99 368325 19948 46297690
Product substitution issue 12.79 9.88 68 368356 14963 46302675
Cardiac failure acute 12.71 9.88 28 368396 8050 46309588
Palpitations 12.70 9.88 618 367806 94641 46222997
Vertigo 12.69 9.88 313 368111 51735 46265903
Haematoma 12.69 9.88 176 368248 31696 46285942
Dehydration 12.66 9.88 1085 367339 158455 46159183
Bone density abnormal 12.59 9.88 53 368371 3031 46314607
Orthostatic hypotension 12.57 9.88 129 368295 24529 46293109
Mass 12.54 9.88 144 368280 11509 46306129
Stillbirth 12.52 9.88 91 368333 6400 46311238
Poor venous access 12.49 9.88 110 368314 8198 46309440
Lip swelling 12.48 9.88 134 368290 25261 46292377
Proteinuria 12.41 9.88 78 368346 16475 46301163
Hypertransaminasaemia 12.39 9.88 6 368418 3482 46314156
Hepatitis cholestatic 12.37 9.88 21 368403 6656 46310982
Disease recurrence 12.37 9.88 90 368334 18381 46299257
Cartilage injury 12.35 9.88 34 368390 1563 46316075
Sickle cell anaemia 12.33 9.88 19 368405 573 46317065
Paralysis 12.32 9.88 32 368392 8689 46308949
Metabolic surgery 12.24 9.88 25 368399 945 46316693
Labelled drug-drug interaction medication error 12.23 9.88 34 368390 9027 46308611
Potentiating drug interaction 12.13 9.88 8 368416 3915 46313723
Human antichimeric antibody positive 12.09 9.88 31 368393 1365 46316273
Antinuclear antibody positive 12.09 9.88 88 368336 6192 46311446
Dysphagia 12.06 9.88 493 367931 76819 46240819
Cerebrovascular accident 12.04 9.88 663 367761 100376 46217262
Tubulointerstitial nephritis 11.98 9.88 68 368356 14720 46302918
Antibody test positive 11.98 9.88 41 368383 2124 46315514
Congenital neuropathy 11.98 9.88 5 368419 17 46317621
Interstitial lung disease 11.95 9.88 329 368095 53620 46264018
Talipes 11.93 9.88 31 368393 1376 46316262
Sinus bradycardia 11.92 9.88 62 368362 13720 46303918
Cardiomyopathy 11.92 9.88 76 368348 15997 46301641
Crying 11.87 9.88 108 368316 21033 46296605
Ileus paralytic 11.84 9.88 10 368414 4313 46313325
Irritability 11.83 9.88 159 368265 28787 46288851
Septic shock 11.82 9.88 357 368067 57536 46260102
Infection susceptibility increased 11.82 9.88 41 368383 2138 46315500
Colitis microscopic 11.80 9.88 21 368403 6535 46311103
Wrong technique in product usage process 11.77 9.88 333 368091 54089 46263549
Renal mass 11.71 9.88 36 368388 1762 46315876
Diabetes mellitus 11.69 9.88 303 368121 49762 46267876
Cardiotoxicity 11.69 9.88 22 368402 6700 46310938
Delusion 11.66 9.88 47 368377 11141 46306497
Hyperthermia 11.63 9.88 29 368395 7985 46309653
Tooth disorder 11.61 9.88 253 368171 23050 46294588
Cushingoid 11.60 9.88 87 368337 6179 46311459
Magnesium deficiency 11.58 9.88 16 368408 436 46317202
Hysterectomy 11.55 9.88 103 368321 7703 46309935
Protein total 11.55 9.88 3 368421 0 46317638
Infective thrombosis 11.55 9.88 3 368421 0 46317638
Dermatitis exfoliative 11.52 9.88 17 368407 5699 46311939
Hepatotoxicity 11.48 9.88 134 368290 24875 46292763
Catheter site pain 11.45 9.88 8 368416 3798 46313840
Abdominal pain upper 11.42 9.88 1312 367112 143993 46173645
Graft versus host disease in gastrointestinal tract 11.41 9.88 3 368421 2547 46315091
Arthritis bacterial 11.40 9.88 81 368343 5655 46311983
Emotional distress 11.37 9.88 172 368252 30535 46287103
Lip pruritus 11.37 9.88 17 368407 499 46317139
Drug ineffective 11.30 9.88 5698 362726 672140 45645498
Dystonia 11.29 9.88 48 368376 11209 46306429
Pancreatitis 11.29 9.88 260 368164 43367 46274271
Joint lock 11.26 9.88 39 368385 2032 46315606
Sepsis 11.24 9.88 922 367502 135092 46182546
Atrioventricular block 11.23 9.88 23 368401 6788 46310850
Ingrown hair 11.15 9.88 16 368408 452 46317186
Epstein-Barr virus infection 11.11 9.88 23 368401 6761 46310877
Bradykinesia 11.08 9.88 9 368415 3957 46313681
Joint dislocation 11.06 9.88 136 368288 11050 46306588
Foetal distress syndrome 11.03 9.88 28 368396 1225 46316413
Hospitalisation 11.02 9.88 399 368025 62986 46254652
Abortion incomplete 11.02 9.88 6 368418 3258 46314380
Chest discomfort 11 9.88 591 367833 89678 46227960
Skin laceration 10.92 9.88 206 368218 18296 46299342
Platelet count decreased 10.90 9.88 662 367762 99362 46218276
Dactylitis 10.86 9.88 27 368397 1166 46316472
Joint warmth 10.83 9.88 28 368396 1239 46316399
Drug abuser 10.83 9.88 6 368418 3227 46314411
Gonorrhoea 10.82 9.88 9 368415 134 46317504
Depression 10.80 9.88 1176 367248 168928 46148710
Respiratory acidosis 10.80 9.88 20 368404 6128 46311510
Chronic graft versus host disease 10.78 9.88 4 368420 2721 46314917
Anterior chamber cleavage syndrome 10.75 9.88 10 368414 174 46317464
Vascular rupture 10.73 9.88 28 368396 1246 46316392
Upper limb fracture 10.72 9.88 179 368245 15534 46302104
Product compounding quality issue 10.71 9.88 9 368415 136 46317502
Urinary retention 10.70 9.88 143 368281 25918 46291720
Chondropathy 10.63 9.88 37 368387 1933 46315705
Stress 10.58 9.88 503 367921 51048 46266590
Musculoskeletal disorder 10.57 9.88 177 368247 15368 46302270
Device breakage 10.56 9.88 40 368384 9652 46307986
Maternal exposure before pregnancy 10.55 9.88 66 368358 4415 46313223
Hyperprolactinaemia 10.48 9.88 5 368419 2927 46314711
Complication associated with device 10.46 9.88 75 368349 15366 46302272
Hepatitis fulminant 10.44 9.88 7 368417 3395 46314243
Incorrect route of product administration 10.42 9.88 81 368343 16302 46301336
Forceps delivery 10.34 9.88 10 368414 183 46317455
Sciatica 10.29 9.88 209 368215 18811 46298827
Paradoxical drug reaction 10.25 9.88 3 368421 2373 46315265
Spinal cord neoplasm 10.25 9.88 11 368413 229 46317409
Tendon disorder 10.20 9.88 71 368353 4924 46312714
Genital haemorrhage 10.14 9.88 23 368401 6543 46311095
Acute myocardial infarction 10.12 9.88 184 368240 31740 46285898
Intracranial pressure increased 10.12 9.88 11 368413 4209 46313429
Vacuum extractor delivery 10.09 9.88 9 368415 148 46317490
Dermatitis bullous 10.08 9.88 29 368395 7614 46310024
Hernia 10.08 9.88 119 368305 9576 46308062
Haemorrhage in pregnancy 10.05 9.88 32 368392 1596 46316042
Hepatic necrosis 10.03 9.88 18 368406 5583 46312055
Foetal anticonvulsant syndrome 10.01 9.88 15 368409 441 46317197
Catheter site erythema 9.98 9.88 10 368414 3973 46313665
Tooth fracture 9.98 9.88 116 368308 9299 46308339
Spinal disorder 9.95 9.88 102 368322 7922 46309716
Acute coronary syndrome 9.93 9.88 44 368380 10160 46307478
Complication of pregnancy 9.90 9.88 16 368408 503 46317135

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 349.20 9.99 723 162057 40474 29749224
Drug abuse 310.08 9.99 40 162740 82032 29707666
Toxicity to various agents 292.78 9.99 319 162461 176864 29612834
Completed suicide 275.93 9.99 98 162682 99394 29690304
Arthralgia 179.61 9.99 1308 161472 134483 29655215
Drug interaction 161.99 9.99 550 162230 199018 29590680
Foetal exposure during pregnancy 156.94 9.99 499 162281 36372 29753326
Intentional overdose 118.12 9.99 39 162741 41442 29748256
Psoriatic arthropathy 115.55 9.99 261 162519 15500 29774198
Joint swelling 99.96 9.99 512 162268 46434 29743264
Nasopharyngitis 89.50 9.99 587 162193 58262 29731436
Overdose 85.41 9.99 209 162571 84128 29705570
Sickle cell anaemia with crisis 83.60 9.99 83 162697 2319 29787379
Acute kidney injury 77.60 9.99 1036 161744 272806 29516892
Premature baby 72.91 9.99 228 162552 16463 29773235
Suicide attempt 72.37 9.99 56 162724 36641 29753057
Exposure during pregnancy 67.47 9.99 153 162627 9108 29780590
Drug reaction with eosinophilia and systemic symptoms 62.09 9.99 39 162741 28449 29761249
Rhabdomyolysis 59.42 9.99 164 162616 63416 29726282
Neonatal respiratory distress syndrome 59.41 9.99 90 162690 3922 29785776
Haemoglobin decreased 59.41 9.99 910 161870 113188 29676510
Blood pressure fluctuation 57.96 9.99 218 162562 17285 29772413
Hepatic function abnormal 57.21 9.99 87 162693 41858 29747840
Serotonin syndrome 56.12 9.99 14 162766 17877 29771821
Tenosynovitis 55.13 9.99 81 162699 3434 29786264
Musculoskeletal stiffness 53.37 9.99 356 162424 35525 29754173
Enthesopathy 53.03 9.99 72 162708 2834 29786864
Death 51.82 9.99 1513 161267 355770 29433928
Atrial septal defect 50.26 9.99 112 162668 6589 29783109
Infusion related reaction 47.44 9.99 380 162400 40184 29749514
Pain 46.87 9.99 1249 161531 171392 29618306
Maternal drugs affecting foetus 45.95 9.99 83 162697 4190 29785508
Respiratory arrest 45.65 9.99 55 162725 29203 29760495
Intentional product misuse 45.29 9.99 74 162706 34593 29755105
Product use in unapproved indication 44.71 9.99 227 162553 73466 29716232
Arthritis 44.39 9.99 255 162525 24146 29765552
Coma 44.34 9.99 96 162684 40353 29749345
Cytomegalovirus infection 41.95 9.99 40 162740 23634 29766064
Psoriasis 41.72 9.99 383 162397 42123 29747575
Coombs positive haemolytic anaemia 41.61 9.99 34 162746 731 29788967
Febrile neutropenia 41.10 9.99 376 162404 106317 29683381
Hypospadias 40.96 9.99 61 162719 2618 29787080
Cardiac failure 40.48 9.99 276 162504 83142 29706556
Maternal exposure during breast feeding 38.59 9.99 46 162734 1586 29788112
Basal cell carcinoma 38.28 9.99 181 162599 15887 29773811
Hypoglycaemia neonatal 38.06 9.99 45 162735 1538 29788160
Intentional self-injury 38.03 9.99 13 162767 13519 29776179
Maternal exposure during pregnancy 37.63 9.99 72 162708 3799 29785899
Low birth weight baby 37.37 9.99 94 162686 5982 29783716
Cardiac arrest 36.72 9.99 325 162455 92525 29697173
Renal failure 36.72 9.99 487 162293 128479 29661219
Small for dates baby 36.67 9.99 64 162716 3144 29786554
Tongue disorder 35.57 9.99 75 162705 4247 29785451
Haemolysis 35.56 9.99 103 162677 7128 29782570
Immune reconstitution inflammatory syndrome 35.41 9.99 4 162776 9097 29780601
Dysmorphism 35.34 9.99 49 162731 1968 29787730
Ventricular septal defect 34.75 9.99 66 162714 3463 29786235
Renal impairment 34.47 9.99 292 162488 83892 29705806
Pain in extremity 34.18 9.99 812 161968 109409 29680289
Poisoning 33.64 9.99 10 162770 11372 29778326
Drug resistance 33.41 9.99 36 162744 20097 29769601
Synovitis 33.35 9.99 123 162657 9660 29780038
Grip strength decreased 32.62 9.99 49 162731 2119 29787579
Syndactyly 32.38 9.99 29 162751 709 29788989
Osteoarthritis 32.23 9.99 190 162590 18159 29771539
Lactic acidosis 31.84 9.99 77 162703 31136 29758562
Bradycardia 31.19 9.99 218 162562 65308 29724390
Angioedema 31.14 9.99 90 162690 34294 29755404
Arthropathy 31.02 9.99 206 162574 20521 29769177
C-reactive protein abnormal 29.78 9.99 82 162698 5511 29784187
Depressed level of consciousness 29.77 9.99 107 162673 38115 29751583
Suicidal ideation 29.54 9.99 99 162681 36015 29753683
Delirium 29.54 9.99 117 162663 40514 29749184
Pulmonary fibrosis 28.86 9.99 166 162614 15724 29773974
Cellulitis 28.63 9.99 384 162396 46400 29743298
Cryptorchism 28.28 9.99 40 162740 1637 29788061
Fatigue 28.27 9.99 2064 160716 318609 29471089
Agitation 28.20 9.99 175 162605 53898 29735800
Muscle swelling 27.71 9.99 20 162760 355 29789343
Substance abuse 27.63 9.99 3 162777 7037 29782661
Agranulocytosis 27.58 9.99 48 162732 21894 29767804
Blood pressure systolic abnormal 26.99 9.99 37 162743 1470 29788228
Peripheral swelling 26.88 9.99 474 162306 60600 29729098
Electrocardiogram QT prolonged 26.81 9.99 102 162678 35733 29753965
Large for dates baby 26.53 9.99 28 162752 842 29788856
Blood pressure increased 26.43 9.99 543 162237 71385 29718313
Drug dependence 26.39 9.99 47 162733 21248 29768450
Sedation 26.38 9.99 30 162750 16343 29773355
Exposure via breast milk 25.78 9.99 37 162743 1535 29788163
Weight decreased 25.63 9.99 1033 161747 149888 29639810
Foetal anticonvulsant syndrome 25.57 9.99 26 162754 748 29788950
Skin cancer 25.40 9.99 98 162682 7863 29781835
Lower respiratory tract infection 25.35 9.99 239 162541 26475 29763223
Sinusitis 25.30 9.99 285 162495 33060 29756638
Multiple organ dysfunction syndrome 25.18 9.99 222 162558 63265 29726433
Hypoglycaemia 25.05 9.99 168 162612 50813 29738885
Alanine aminotransferase abnormal 24.59 9.99 48 162732 2571 29787127
Drug withdrawal syndrome 24.30 9.99 44 162736 19765 29769933
Therapeutic product effect decreased 24.13 9.99 253 162527 28823 29760875
Poor venous access 23.95 9.99 46 162734 2434 29787264
Knee arthroplasty 23.75 9.99 76 162704 5554 29784144
Skin lesion 23.69 9.99 177 162603 18317 29771381
Cholestasis 23.56 9.99 64 162716 24886 29764812
Hepatocellular injury 23.56 9.99 66 162714 25405 29764293
Aggression 23.34 9.99 112 162668 36795 29752903
Lymphadenitis 23.26 9.99 37 162743 1683 29788015
Off label use 23.17 9.99 1113 161667 248177 29541521
Palmar-plantar erythrodysaesthesia syndrome 23.14 9.99 28 162752 14842 29774856
Vitamin D deficiency 22.92 9.99 71 162709 5099 29784599
Blood creatine phosphokinase increased 22.81 9.99 142 162638 43706 29745992
Pneumonia 22.74 9.99 2110 160670 332196 29457502
Blood pressure systolic increased 22.51 9.99 150 162630 14960 29774738
Rheumatoid nodule 22.36 9.99 36 162744 1654 29788044
Drug intolerance 21.92 9.99 357 162423 44934 29744764
Somnolence 21.83 9.99 382 162398 96381 29693317
Red blood cell count decreased 21.83 9.99 229 162551 26092 29763606
Congenital hand malformation 21.82 9.99 19 162761 447 29789251
Post procedural infection 21.41 9.99 64 162716 4508 29785190
Haematocrit decreased 21.34 9.99 258 162522 30441 29759257
Mass 21.25 9.99 86 162694 7054 29782644
Neuroleptic malignant syndrome 21.08 9.99 35 162745 16260 29773438
Influenza 20.98 9.99 342 162438 43056 29746642
Juvenile idiopathic arthritis 20.82 9.99 27 162753 1016 29788682
Serum ferritin increased 20.80 9.99 71 162709 5366 29784332
Cardio-respiratory arrest 20.74 9.99 205 162575 57101 29732597
Musculoskeletal pain 20.63 9.99 258 162522 30682 29759016
Shock 20.58 9.99 60 162720 22799 29766899
Oropharyngeal pain 20.47 9.99 241 162539 28255 29761443
Status epilepticus 20.45 9.99 18 162762 11054 29778644
Arthritis bacterial 20.44 9.99 62 162718 4402 29785296
Hyperglycaemia 19.90 9.99 111 162669 35089 29754609
Pancytopenia 19.87 9.99 604 162176 84448 29705250
Caesarean section 19.86 9.99 39 162741 2098 29787600
Selective eating disorder 19.78 9.99 34 162746 1650 29788048
Psychotic disorder 19.71 9.99 56 162724 21459 29768239
Medical device implantation 19.57 9.99 19 162761 516 29789182
Interstitial lung disease 19.50 9.99 221 162559 59976 29729722
Tendonitis 19.49 9.99 91 162689 7945 29781753
Immunodeficiency 19.06 9.99 59 162721 4235 29785463
Injection site pain 19.04 9.99 250 162530 30060 29759638
Incorrect route of product administration 19.03 9.99 20 162760 11295 29778403
Back pain 18.99 9.99 709 162071 101887 29687811
Tonsil cancer 18.74 9.99 22 162758 746 29788952
Kidney infection 18.59 9.99 61 162719 4517 29785181
Toxic epidermal necrolysis 18.50 9.99 44 162736 17896 29771802
Localised infection 18.47 9.99 133 162647 13604 29776094
Wound 18.40 9.99 123 162657 12279 29777419
Body temperature decreased 18.28 9.99 102 162678 9553 29780145
Agitation neonatal 18.11 9.99 25 162755 1000 29788698
Pyrexia 18.09 9.99 1367 161413 293122 29496576
Eosinophilia 17.95 9.99 61 162719 22099 29767599
Neutrophil count decreased 17.93 9.99 146 162634 42308 29747390
Mean cell volume increased 17.81 9.99 37 162743 2073 29787625
Full blood count decreased 17.69 9.99 146 162634 15571 29774127
Altered state of consciousness 17.41 9.99 53 162727 19866 29769832
Prostate cancer 17.38 9.99 203 162577 23754 29765944
Cytokine release syndrome 17.34 9.99 17 162763 9916 29779782
Talipes 17.33 9.99 32 162748 1643 29788055
Malignant melanoma 17.30 9.99 83 162697 7328 29782370
Loss of personal independence in daily activities 17.22 9.99 186 162594 21349 29768349
Hypocalcaemia 17.21 9.99 59 162721 21317 29768381
Hand deformity 17.19 9.99 34 162746 1839 29787859
Joint range of motion decreased 17.08 9.99 70 162710 5775 29783923
Foot deformity 16.94 9.99 49 162731 3388 29786310
Joint effusion 16.89 9.99 51 162729 3612 29786086
Speech disorder developmental 16.83 9.99 26 162754 1153 29788545
Drug level increased 16.65 9.99 48 162732 18306 29771392
Lacrimal disorder 16.49 9.99 14 162766 318 29789380
Urinary tract infection 16.38 9.99 520 162260 73139 29716559
Haemangioma congenital 16.17 9.99 17 162763 509 29789189
Akathisia 16.03 9.99 6 162774 5898 29783800
Venoocclusive liver disease 15.92 9.99 8 162772 6605 29783093
Diabetic ketoacidosis 15.86 9.99 40 162740 15946 29773752
Hepatic enzyme increased 15.83 9.99 263 162517 33231 29756467
Foetal growth restriction 15.68 9.99 49 162731 3536 29786162
Product quality issue 15.67 9.99 51 162729 18723 29770975
Acute hepatic failure 15.67 9.99 25 162755 11802 29777896
Hyperbilirubinaemia neonatal 15.58 9.99 19 162761 671 29789027
Injection site bruising 15.58 9.99 80 162700 7258 29782440
Rash maculo-papular 15.57 9.99 78 162702 25340 29764358
Neurotoxicity 15.53 9.99 30 162750 13152 29776546
Arthrodesis 15.43 9.99 15 162765 408 29789290
Congenital bladder anomaly 15.40 9.99 13 162767 293 29789405
Blood pressure diastolic increased 15.25 9.99 41 162739 2717 29786981
Anal fistula 15.20 9.99 52 162728 3934 29785764
Progressive multifocal leukoencephalopathy 15.08 9.99 16 162764 8997 29780701
Drug eruption 15.06 9.99 47 162733 17479 29772219
Asthma 15.01 9.99 125 162655 36049 29753649
Neck mass 14.88 9.99 27 162753 1368 29788330
Tachycardia 14.80 9.99 297 162483 73442 29716256
Multiple congenital abnormalities 14.80 9.99 16 162764 495 29789203
Crystal nephropathy 14.67 9.99 14 162766 372 29789326
Back disorder 14.62 9.99 68 162712 5926 29783772
Septic arthritis staphylococcal 14.46 9.99 15 162765 442 29789256
Cleft lip 14.44 9.99 13 162767 320 29789378
Spinal stenosis 14.40 9.99 54 162726 4275 29785423
Weight decrease neonatal 14.31 9.99 13 162767 324 29789374
Gamma-glutamyltransferase increased 14.27 9.99 97 162683 29253 29760445
Bradycardia neonatal 14.21 9.99 21 162759 895 29788803
Hypokalaemia 14.09 9.99 190 162590 50002 29739696
Jaundice neonatal 14.02 9.99 23 162757 1074 29788624
Ankyloglossia congenital 13.94 9.99 12 162768 278 29789420
Lipase increased 13.86 9.99 16 162764 8660 29781038
Blood pressure diastolic abnormal 13.84 9.99 25 162755 1262 29788436
Upper respiratory tract infection 13.83 9.99 218 162562 27258 29762440
Hypermobility syndrome 13.52 9.99 11 162769 235 29789463
Hepatic failure 13.51 9.99 119 162661 33924 29755774
Osteonecrosis of jaw 13.28 9.99 54 162726 18564 29771134
Cataract 13.26 9.99 179 162601 21656 29768042
Transaminases increased 13.24 9.99 74 162706 23383 29766315
Aspergillus infection 13.15 9.99 22 162758 10192 29779506
Foetal disorder 13.08 9.99 17 162763 641 29789057
Hepatocellular carcinoma 13.03 9.99 20 162760 9590 29780108
Cerebral haemorrhage 13.03 9.99 115 162665 32772 29756926
Pleural fibrosis 12.99 9.99 26 162754 1418 29788280
Hepatic encephalopathy 12.96 9.99 37 162743 14155 29775543
Hallucination 12.95 9.99 188 162592 48871 29740827
Nephrolithiasis 12.92 9.99 198 162582 24612 29765086
Frequent bowel movements 12.86 9.99 84 162696 8321 29781377
Immunosuppression 12.84 9.99 59 162721 5116 29784582
Acute graft versus host disease 12.81 9.99 8 162772 5856 29783842
Renal injury 12.71 9.99 28 162752 11701 29777997
Proteinuria 12.70 9.99 45 162735 16100 29773598
Renal aplasia 12.68 9.99 17 162763 661 29789037
Patent ductus arteriosus 12.67 9.99 42 162738 3127 29786571
Gastrointestinal tract mucosal discolouration 12.66 9.99 3 162777 0 29789698
Cystatin C increased 12.66 9.99 3 162777 0 29789698
Stevens-Johnson syndrome 12.47 9.99 51 162729 17505 29772193
Haemorrhage intracranial 12.43 9.99 41 162739 14991 29774707
Accidental overdose 12.42 9.99 54 162726 18221 29771477
Hepatitis 12.36 9.99 71 162709 22285 29767413
Heart rate decreased 12.30 9.99 171 162609 20823 29768875
Thrombocytopenia 12.27 9.99 614 162166 136430 29653268
Alcohol abuse 12.12 9.99 7 162773 5346 29784352
Drug-induced liver injury 12.07 9.99 67 162713 21207 29768491
Victim of child abuse 11.95 9.99 11 162769 279 29789419
Disseminated intravascular coagulation 11.95 9.99 71 162709 22100 29767598
Myoclonus 11.94 9.99 35 162745 13277 29776421
Posterior reversible encephalopathy syndrome 11.92 9.99 18 162762 8689 29781009
Pathogen resistance 11.90 9.99 17 162763 8393 29781305
Arthritis infective 11.88 9.99 37 162743 2665 29787033
Crohn's disease 11.84 9.99 51 162729 4301 29785397
Hyperkalaemia 11.75 9.99 271 162509 65739 29723959
Hernia pain 11.75 9.99 10 162770 228 29789470
Vascular insufficiency 11.69 9.99 12 162768 349 29789349
Dermatitis psoriasiform 11.65 9.99 22 162758 1149 29788549
Maternal exposure timing unspecified 11.61 9.99 12 162768 352 29789346
Chronic graft versus host disease 11.50 9.99 4 162776 4115 29785583
Hyperammonaemia 11.43 9.99 8 162772 5512 29784186
Nightmare 11.38 9.99 31 162749 12045 29777653
Asthenia 11.36 9.99 1371 161409 219919 29569779
Abnormal behaviour 11.34 9.99 87 162693 25536 29764162
Hallucination, visual 11.33 9.99 47 162733 16066 29773632
Intellectual disability 11.29 9.99 18 162762 820 29788878
Pyelocaliectasis 11.25 9.99 20 162760 997 29788701
Bronchopulmonary aspergillosis 11.23 9.99 32 162748 12252 29777446
Cystitis haemorrhagic 11.22 9.99 6 162774 4781 29784917
Coccydynia 11.21 9.99 12 162768 367 29789331
Blood insulin increased 11.18 9.99 12 162768 368 29789330
Subdural haematoma 11.18 9.99 59 162721 18913 29770785
Peripheral artery thrombosis 11.17 9.99 32 162748 2200 29787498
Anal atresia 11.15 9.99 11 162769 305 29789393
Delusion 11.13 9.99 31 162749 11958 29777740
Mouth ulceration 11.12 9.99 97 162683 10512 29779186
Otitis media 11.11 9.99 35 162745 2536 29787162
Contusion 11.11 9.99 235 162545 31045 29758653
Joint stiffness 11.10 9.99 88 162692 9273 29780425
Blood iron increased 11.04 9.99 18 162762 836 29788862
Arthropod bite 11.03 9.99 33 162747 2325 29787373
Myocardial infarction 11.02 9.99 564 162216 125061 29664637
Anaphylactic shock 11.01 9.99 39 162741 13954 29775744
Cerebral infarction 11.00 9.99 91 162689 26282 29763416
Fistula 10.98 9.99 56 162724 5066 29784632
Intervertebral disc degeneration 10.98 9.99 57 162723 5194 29784504
Cytomegalovirus viraemia 10.97 9.99 9 162771 5720 29783978
Rhinorrhoea 10.95 9.99 166 162614 20588 29769110
Congenital anomaly 10.95 9.99 23 162757 1299 29788399
Infected bite 10.94 9.99 11 162769 312 29789386
Hepatitis C 10.93 9.99 36 162744 13169 29776529
Infection 10.92 9.99 524 162256 77550 29712148
Microphthalmos 10.92 9.99 9 162771 196 29789502
Palindromic rheumatism 10.92 9.99 9 162771 196 29789502
Hydrocele 10.91 9.99 30 162750 2014 29787684
Lung hernia 10.90 9.99 5 162775 35 29789663
Lung neoplasm malignant 10.87 9.99 128 162652 15004 29774694
Injection site erythema 10.83 9.99 119 162661 13715 29775983
Metabolic acidosis 10.81 9.99 141 162639 37320 29752378
Joint instability 10.80 9.99 12 162768 383 29789315
Diverticulum 10.73 9.99 68 162712 6665 29783033
Blood iron decreased 10.73 9.99 47 162733 3993 29785705
Hepatitis fulminant 10.71 9.99 4 162776 3937 29785761
Steatorrhoea 10.68 9.99 16 162764 690 29789008
Migraine 10.67 9.99 112 162668 12762 29776936
Injection site swelling 10.67 9.99 83 162697 8697 29781001
Pulmonary alveolar haemorrhage 10.66 9.99 12 162768 6569 29783129
Plagiocephaly 10.63 9.99 11 162769 323 29789375
Spinal operation 10.62 9.99 32 162748 2264 29787434
Blood pressure diastolic decreased 10.61 9.99 64 162716 6167 29783531
Excessive cerumen production 10.60 9.99 10 162770 262 29789436
Exostosis 10.59 9.99 42 162738 3413 29786285
Gangrene neonatal 10.58 9.99 9 162771 205 29789493
Electrocardiogram QRS complex prolonged 10.56 9.99 5 162775 4272 29785426
Neonatal seizure 10.49 9.99 13 162767 467 29789231
Erythema multiforme 10.47 9.99 17 162763 7968 29781730
Hypertransaminasaemia 10.46 9.99 4 162776 3881 29785817
Graft versus host disease 10.38 9.99 25 162755 10125 29779573
Tubulointerstitial nephritis 10.34 9.99 56 162724 17835 29771863
Blister infected 10.34 9.99 11 162769 334 29789364
Energy increased 10.34 9.99 22 162758 1254 29788444
Nocardiosis 10.28 9.99 3 162777 3452 29786246
Microcephaly 10.19 9.99 15 162765 637 29789061
Malignant neoplasm progression 10.17 9.99 307 162473 71980 29717718
Congenital diaphragmatic hernia 10.15 9.99 9 162771 217 29789481
Folate deficiency 10.10 9.99 19 162761 990 29788708
Drug withdrawal syndrome neonatal 10.06 9.99 39 162741 3136 29786562
Umbilical hernia 10.04 9.99 43 162737 3618 29786080
Foetal heart rate deceleration abnormality 10.02 9.99 12 162768 416 29789282

Pharmacologic Action:

SourceCodeDescription
ATC A11GA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS
Ascorbic acid (vitamin C), plain
ATC A11GB01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS
Ascorbic acid (vitamin C), combinations
ATC G01AD03 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Organic acids
ATC S01XA15 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA CS M0001797 Ascorbic Acid
MeSH PA D000975 Antioxidants
MeSH PA D018977 Micronutrients
MeSH PA D020011 Protective Agents
MeSH PA D014815 Vitamins
FDA EPC N0000193618 Vitamin C
CHEBI has role CHEBI:21241 vitaminum c
CHEBI has role CHEBI:23354 coenzymes
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:27314 water-soluble vitamins
CHEBI has role CHEBI:64577 improving agents
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77962 food antioxidants
CHEBI has role CHEBI:77746 h. sapiens metabolites
CHEBI has role CHEBI:83056 daphnia magna metabolites
CHEBI has role CHEBI:63247 reductants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ascorbic acid deficiency indication 76169001
Breastfeeding (mother) indication 413712001
Coronavirus infection off-label use 186747009
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Peptic ulcer contraindication 13200003 DOID:750
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Operation on stomach contraindication 16453004
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hypocupremia contraindication 19577007
Hyperphosphatemia contraindication 20165001 DOID:0050459
Sunburn contraindication 23346002
Acute vomiting contraindication 23971007
Multiple sclerosis contraindication 24700007 DOID:2377
Gastroenteritis contraindication 25374005 DOID:2326
Acute tuberculosis contraindication 25629007
Hypervitaminosis D contraindication 27712000 DOID:9971
Complete atrioventricular block contraindication 27885002
Toxic megacolon contraindication 28536002 DOID:1770
Dental fluorosis contraindication 30265004
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Hemosiderosis contraindication 39011001 DOID:12119
Gastrointestinal ulcer contraindication 40845000
Toxic colitis contraindication 42359007
Hypokalemia contraindication 43339004
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hyperlipidemia contraindication 55822004 DOID:1168
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Leber's optic atrophy contraindication 58610003 DOID:705
Hemolytic anemia contraindication 61261009 DOID:583
Allergic rhinitis contraindication 61582004
Hypervitaminosis A contraindication 64559002 DOID:9972
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Rheumatoid arthritis contraindication 69896004 DOID:7148
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperchloremia contraindication 74450001
Third degree burn injury contraindication 80247002
Intestinal obstruction contraindication 81060008 DOID:8437
Atrophic gastritis contraindication 84568007 DOID:8929
Human immunodeficiency virus infection contraindication 86406008 DOID:526
Wilson's disease contraindication 88518009
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Leukemia, disease contraindication 93143009 DOID:1240
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Gastrointestinal obstruction contraindication 126765001
Hb SS disease contraindication 127040003 DOID:10923
Seizure disorder contraindication 128613002
Osteolysis contraindication 203522001
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Esophageal dysmotility contraindication 266434009 DOID:9192
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Gastric retention contraindication 307227006
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
At risk for aspiration contraindication 371736008
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Denuded skin contraindication 418242004
Severe dehydration contraindication 450316000
Acute exacerbation of asthma contraindication 708038006
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Malabsorption States contraindication
Repeated Blood Transfusions contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.02 acidic
pKa2 9.62 acidic
pKa3 11.85 acidic
pKa4 12.53 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
4.7GM;100GM;1.015GM;5.9GM;2.691GM;7.5GM PEG-3350, SODIUM SULFATE, SODIUM CHLORIDE, POTASSIUM CHLORIDE, SODIUM ASCORBATE AND ASCORBIC ACID NOVEL LABS INC A090145 Jan. 25, 2012 RX FOR SOLUTION ORAL Feb. 27, 2021 PATENT CHALLENGE
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL May 4, 2021 NEW PRODUCT
25,000MG/50ML (500MG/ML) ASCOR MCGUFF N209112 Oct. 2, 2017 RX SOLUTION INTRAVENOUS Oct. 2, 2024 FOR TREATMENT OF SCURVY IN ADULT AND PEDIATRIC PATIENTS AGE 5 MONTHS AND OLDER FOR WHOM ORAL ADMINISTRATION IS NOT POSSIBLE, INSUFFICIENT OR CONTRAINDICATED

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 23 member 1 Unclassified WOMBAT-PK
Solute carrier family 23 member 2 Transporter WOMBAT-PK
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Enzyme WOMBAT-PK
Prolyl 4-hydroxylase subunit alpha-1 Enzyme WOMBAT-PK
Tyrosinase Enzyme IC50 4.49 CHEMBL
Pancreatic alpha-amylase Unclassified IC50 4.58 CHEMBL

External reference:

IDSource
PQ6CK8PD0R UNII
4017646 VUID
N0000146025 NUI
D00018 KEGG_DRUG
5743-28-2 SECONDARY_CAS_RN
4017471 VANDF
4017472 VANDF
4017646 VANDF
4021716 VANDF
4026966 VANDF
C0003968 UMLSCUI
CHEBI:29073 CHEBI
ASC PDB_CHEM_ID
CHEMBL196 ChEMBL_ID
CHEMBL2146095 ChEMBL_ID
DB00126 DRUGBANK_ID
DB14483 DRUGBANK_ID
CHEMBL591665 ChEMBL_ID
D001205 MESH_DESCRIPTOR_UI
54670067 PUBCHEM_CID
372 INN_ID
C069207 MESH_SUPPLEMENTAL_RECORD_UI
4781 IUPHAR_LIGAND_ID
174 INN_ID
DB14482 DRUGBANK_ID
1151 RXNORM
1132 MMSL
32646 MMSL
4221 MMSL
5471 MMSL
5687 MMSL
6032 MMSL
72299 MMSL
NOCODE MMSL
d00426 MMSL
001010 NDDF
001011 NDDF
001012 NDDF
126230002 SNOMEDCT_US
126231003 SNOMEDCT_US
43706004 SNOMEDCT_US
46123006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 120 mg ORAL unapproved drug other 17 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 120 mg ORAL Unapproved drug other 12 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 138 mg ORAL unapproved drug other 15 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 120 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 120 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 120 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 120 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 120 mg ORAL Unapproved drug other 11 sections
Antiflu Kids HUMAN OTC DRUG LABEL 3 0280-0046 POWDER, FOR SOLUTION 50 mg ORAL Export only 2 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 30 mg ORAL unapproved drug other 7 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 60 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 60 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 70 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 12 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 30 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 60 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 500 mg ORAL UNULLPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 300 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 30 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 60 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 100 mg ORAL UNULLPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 500 mg ORAL UNULLPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 70 mg ORAL UNULLPPROVED DRUG OTHER 6 sections
Acetaminophen, Ascorbic acid, Chlorpheniramine Maleate HUMAN OTC DRUG LABEL 3 10267-2949 POWDER, FOR SOLUTION 50 mg ORAL Export only 1 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
PRENULLTAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 120 mg ORAL unapproved drug other 8 sections