ascorbic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4072 50-81-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vitamin c
  • L-Ascorbic acid
  • ascorbic acid
  • ascorbic acid (vit C)
  • sodium ascorbate
  • calcium ascorbate
  • ascorbic acid, monosodium salt
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. NIH COVID-19 Treatment Guidelines Panel states that there are insufficient data to recommend either for or against use of ascorbic acid for the treatment of COVID-19 in critically or noncritically ill patients.
  • Molecular weight: 176.12
  • Formula: C6H8O6
  • CLOGP: -1.76
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 107.22
  • ALOGS: 0.14
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P
0.25 g V

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 0 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 333 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 25 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 567.77 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.35 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.05 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.26 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 11.40 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GRK3,GSK3B,ITK,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MTOR,NTRK1,NTRK2,PDK1,PDK2,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK 47
kinase-selectivity-class ACVR2B,ACVRL1,AXL,BMX,BRAF,CDK4,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,IKBKB,JAK2,MAP2K6,MAP3K14,MAP3K2,MAPK7,MAPK8,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70 25
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1202.43 10.06 99 983415 144959 89499974
Pemphigus 1090.24 10.06 6664 976850 320200 89324733
Systemic lupus erythematosus 1070.78 10.06 7157 976357 354739 89290194
Toxicity to various agents 1059.73 10.06 938 982576 286908 89358025
Glossodynia 929.57 10.06 6327 977187 315452 89329481
Arthropathy 782.87 10.06 6711 976803 359531 89285402
Hand deformity 746.56 10.06 5639 977875 290723 89354210
Abdominal discomfort 719.53 10.06 8131 975383 469197 89175736
Alopecia 684.84 10.06 8295 975219 486776 89158157
Intentional overdose 657.29 10.06 113 983401 93721 89551212
Drug interaction 649.43 10.06 1259 982255 275194 89369739
Wound 621.12 10.06 5502 978012 297478 89347455
Death 599.99 10.06 2730 980784 453821 89191112
Pain 586.43 10.06 14540 968974 981801 88663132
Joint swelling 577.81 10.06 8151 975363 495149 89149784
Contraindicated product administered 520.57 10.06 5538 977976 314601 89330332
Swelling 515.46 10.06 6872 976642 412186 89232747
Synovitis 505.15 10.06 5637 977877 324115 89320818
Pericarditis 494.60 10.06 4789 978725 265362 89379571
Infusion related reaction 491.40 10.06 6783 976731 409997 89234936
Anti-cyclic citrullinated peptide antibody positive 491.24 10.06 4307 979207 232126 89412807
Maternal exposure during pregnancy 485.95 10.06 6007 977507 354056 89290877
Rheumatoid arthritis 482.28 10.06 6033 977481 356581 89288352
Febrile neutropenia 464.95 10.06 622 982892 157727 89487206
Suicide attempt 442.03 10.06 134 983380 75265 89569668
Discomfort 438.53 10.06 4730 978784 269605 89375328
Drug abuse 438.48 10.06 172 983342 82175 89562758
Acute kidney injury 385.47 10.06 1976 981538 318411 89326522
Duodenal ulcer perforation 373.04 10.06 3857 979657 217431 89427502
Neutropenia 369.25 10.06 1229 982285 223675 89421258
Cardiac arrest 343.10 10.06 379 983135 104556 89540377
Helicobacter infection 340.73 10.06 3864 979650 222986 89421947
Malignant neoplasm progression 339.62 10.06 395 983119 106475 89538458
Hepatic enzyme increased 337.08 10.06 5644 977870 355092 89289841
Disease progression 310.97 10.06 782 982732 155833 89489100
Electrocardiogram QT prolonged 304.55 10.06 206 983308 72250 89572683
Psoriatic arthropathy 288.77 10.06 3765 979749 224570 89420363
Lactic acidosis 269.31 10.06 105 983409 50358 89594575
Rheumatoid factor positive 265.47 10.06 2941 980573 168709 89476224
Arthralgia 251.96 10.06 10584 972930 767938 88876995
Product use issue 249.60 10.06 4995 978519 324924 89320009
Cardiac failure 239.58 10.06 519 982995 108977 89535956
Impaired healing 227.29 10.06 3688 979826 230511 89414422
Drug reaction with eosinophilia and systemic symptoms 213.70 10.06 98 983416 42660 89602273
Therapeutic product effect decreased 210.04 10.06 4203 979311 273368 89371565
Hyponatraemia 206.08 10.06 749 982765 132789 89512144
Folliculitis 203.13 10.06 3231 980283 201122 89443811
Lower respiratory tract infection 198.22 10.06 3821 979693 246838 89398095
Exposure during pregnancy 195.98 10.06 3656 979858 234754 89410179
Drug ineffective for unapproved indication 195.31 10.06 262 983252 66382 89578551
Musculoskeletal stiffness 194.28 10.06 4397 979117 292135 89352798
Serotonin syndrome 193.81 10.06 84 983430 37803 89607130
Bradycardia 190.50 10.06 389 983125 83458 89561475
Sopor 188.04 10.06 23 983491 24621 89620312
Hypersensitivity 187.60 10.06 6352 977162 448325 89196608
Nasopharyngitis 184.65 10.06 5752 977762 401352 89243581
Renal impairment 183.45 10.06 561 982953 104860 89540073
Depressed level of consciousness 181.75 10.06 319 983195 72465 89572468
Renal failure 181.59 10.06 767 982747 130240 89514693
Myelosuppression 181.35 10.06 188 983326 53403 89591530
Hypotension 178.97 10.06 2470 981044 322927 89322006
Rhabdomyolysis 177.79 10.06 176 983338 51080 89593853
Angioedema 177.29 10.06 268 983246 64608 89580325
Rheumatic fever 177.09 10.06 2485 981029 150636 89494297
Blister 173.58 10.06 3802 979712 251196 89393737
Metabolic acidosis 170.25 10.06 212 983302 55464 89589469
Muscle injury 166.93 10.06 2770 980744 173884 89471049
Agitation 166.71 10.06 295 983219 66803 89578130
Somnolence 166.51 10.06 1458 982056 207626 89437307
Intentional self-injury 165.06 10.06 56 983458 29278 89615655
Nausea 163.42 10.06 10131 973383 1100185 88544748
Irritable bowel syndrome 162.84 10.06 3159 980355 204289 89440644
Fibromyalgia 161.22 10.06 3139 980375 203130 89441803
Sinusitis 158.82 10.06 4860 978654 338228 89306705
Hypoglycaemia 158.72 10.06 324 983190 69524 89575409
Fatigue 157.26 10.06 14546 968968 1139477 88505456
Cardio-respiratory arrest 155.61 10.06 279 983235 62861 89582072
Drug resistance 154.97 10.06 68 983446 30381 89614552
Coma 153.36 10.06 351 983163 72281 89572652
Multiple organ dysfunction syndrome 151.89 10.06 321 983193 68015 89576918
Blood cholesterol increased 150.41 10.06 3129 980385 204883 89440050
Sleep disorder due to general medical condition, insomnia type 149.37 10.06 2090 981424 126604 89518329
Tachycardia 148.07 10.06 1051 982463 156622 89488311
No adverse event 143.96 10.06 328 983186 67654 89577279
Overdose 141.48 10.06 1065 982449 156644 89488289
Swollen joint count increased 140.15 10.06 1833 981681 109373 89535560
Off label use 139.84 10.06 10190 973324 1092062 88552871
Type 2 diabetes mellitus 138.79 10.06 3032 980482 200212 89444721
Knee arthroplasty 137.68 10.06 1445 982069 81737 89563196
Respiratory arrest 136.92 10.06 97 983417 33214 89611719
Respiratory failure 133.52 10.06 746 982768 117672 89527261
Hip arthroplasty 132.87 10.06 1338 982176 74870 89570063
Seizure 129.75 10.06 1046 982468 151583 89493350
Cytokine release syndrome 129.44 10.06 71 983443 27902 89617031
Altered state of consciousness 128.06 10.06 93 983421 31439 89613494
Ill-defined disorder 125.84 10.06 2757 980757 182134 89462799
Anaemia 124.59 10.06 2896 980618 349906 89295027
Device expulsion 122.60 10.06 158 983356 40728 89604205
Treatment failure 122.15 10.06 4234 979280 299694 89345239
Drug intolerance 121.62 10.06 5981 977533 441610 89203323
Hepatocellular injury 120.78 10.06 83 983431 28875 89616058
Immunodeficiency 120.23 10.06 843 982671 42391 89602542
Osteoarthritis 119.67 10.06 2875 980639 192855 89452078
Peripheral swelling 117.66 10.06 5546 977968 407560 89237373
Hepatic failure 116.59 10.06 156 983358 39572 89605361
Hyperkalaemia 116.39 10.06 341 983173 64623 89580310
Tremor 114.57 10.06 1085 982429 152088 89492845
Bursitis 113.72 10.06 2035 981479 129619 89515314
Contusion 112.82 10.06 3546 979968 247670 89397263
Cholestasis 111.21 10.06 138 983376 36161 89608772
Syncope 109.64 10.06 916 982598 131747 89513186
Cytomegalovirus infection 107.34 10.06 79 983435 26523 89618410
Stomatitis 106.93 10.06 3813 979701 270885 89374048
Anaphylactic shock 106.87 10.06 111 983403 31506 89613427
Sickle cell anaemia with crisis 106.43 10.06 241 983273 7056 89637877
Red blood cell sedimentation rate abnormal 106.17 10.06 532 982982 23672 89621261
Shock 104.27 10.06 95 983419 28683 89616250
Metastases to bone 102.57 10.06 76 983438 25429 89619504
Rash 101.99 10.06 9994 973520 786106 88858827
Encephalopathy 101.68 10.06 220 983294 46224 89598709
Hepatic function abnormal 101.56 10.06 219 983295 46069 89598864
Hypoxia 101.46 10.06 422 983092 71977 89572956
Drug dependence 100.22 10.06 102 983412 29225 89615708
Weight increased 99.79 10.06 5517 977997 412410 89232523
Anaphylactic reaction 98.86 10.06 551 982963 86973 89557960
Thrombocytopenia 97.99 10.06 1633 981881 207092 89437841
Leukopenia 97.63 10.06 665 982849 100045 89544888
Suicidal ideation 96.49 10.06 442 983072 73413 89571520
Hyperglycaemia 95.40 10.06 262 983252 50708 89594225
Ventricular tachycardia 95.08 10.06 77 983437 24631 89620302
Dyspnoea 94.63 10.06 8253 975261 872702 88772231
C-reactive protein abnormal 93.42 10.06 1921 981593 125508 89519425
Dysarthria 92.59 10.06 293 983221 54189 89590744
Schizophrenia 92.05 10.06 24 983490 14890 89630043
Sepsis 91.03 10.06 1387 982127 178427 89466506
Torsade de pointes 90.76 10.06 26 983488 15156 89629777
Night sweats 89.47 10.06 1926 981588 126840 89518093
Neoplasm progression 89.12 10.06 221 983293 44265 89600668
Poisoning 87.46 10.06 28 983486 15189 89629744
Liver injury 87.22 10.06 2447 981067 168120 89476813
Accidental exposure to product 86.82 10.06 208 983306 42158 89602775
Metastases to liver 85.67 10.06 112 983402 28695 89616238
Drug level increased 85.62 10.06 105 983409 27657 89617276
Mydriasis 85.61 10.06 28 983486 14984 89629949
Hallucination 85.42 10.06 396 983118 65563 89579370
Diabetic ketoacidosis 84.42 10.06 84 983430 24323 89620610
Acute hepatic failure 83.51 10.06 73 983441 22488 89622445
Palmar-plantar erythrodysaesthesia syndrome 83.29 10.06 109 983405 27914 89617019
Product use in unapproved indication 81.18 10.06 2908 980606 333328 89311605
Thrombotic microangiopathy 80.37 10.06 35 983479 15708 89629225
Intentional product use issue 79.36 10.06 2990 980524 213902 89431031
Sedation 78.44 10.06 264 983250 47907 89597026
Hypokalaemia 78.30 10.06 978 982536 130138 89514795
Neutrophil count decreased 78.26 10.06 455 983059 71077 89573856
Psoriasis 78.15 10.06 2129 981385 145625 89499308
Pregnancy 77.85 10.06 1022 982492 61025 89583908
Chest discomfort 77.50 10.06 1046 982468 137319 89507614
Extrapyramidal disorder 77.46 10.06 40 983474 16263 89628670
Therapy partial responder 77.24 10.06 75 983439 21968 89622965
Injury 75.93 10.06 2736 980778 194613 89450320
Neurotoxicity 75.27 10.06 73 983441 21394 89623539
Disorientation 75.13 10.06 237 983277 43877 89601056
Drug withdrawal syndrome 74.35 10.06 123 983391 28600 89616333
Dehydration 74.32 10.06 1576 981938 192871 89452062
Drug use disorder 74.07 10.06 4 983510 8339 89636594
Parkinsonism 73.84 10.06 30 983484 14035 89630898
Polyneuropathy 73.52 10.06 61 983453 19280 89625653
Temperature regulation disorder 72.30 10.06 332 983182 14247 89630686
Wrong technique in product usage process 72.17 10.06 467 983047 71104 89573829
Loss of consciousness 71.21 10.06 1081 982433 139157 89505776
Ear pain 69.73 10.06 944 982570 56758 89588175
Palpitations 69.07 10.06 1055 982459 135673 89509260
Haematotoxicity 68.69 10.06 25 983489 12510 89632423
Hypothermia 68.55 10.06 42 983472 15533 89629400
Respiratory depression 68.55 10.06 42 983472 15533 89629400
Myalgia 68.50 10.06 1414 982100 173711 89471222
Neuropathy peripheral 68.46 10.06 1059 982455 135911 89509022
Blood creatine phosphokinase increased 68.17 10.06 169 983345 33854 89611079
Grip strength decreased 67.32 10.06 1394 982120 91182 89553751
Hepatic cytolysis 67.22 10.06 147 983367 30769 89614164
Exposure to toxic agent 67.21 10.06 5 983509 7962 89636971
Device difficult to use 66.96 10.06 55 983459 17470 89627463
Mobility decreased 66.83 10.06 3345 980169 247389 89397544
Posterior reversible encephalopathy syndrome 66.28 10.06 87 983427 22252 89622681
Blood bilirubin increased 66.25 10.06 245 983269 43225 89601708
Osteonecrosis of jaw 65.95 10.06 211 983303 38892 89606041
Disseminated intravascular coagulation 65.85 10.06 82 983432 21456 89623477
Ejection fraction decreased 65.59 10.06 115 983399 26138 89618795
Unresponsive to stimuli 65.49 10.06 204 983310 37917 89607016
Inappropriate antidiuretic hormone secretion 65.34 10.06 69 983445 19436 89625497
Status epilepticus 65.23 10.06 65 983449 18809 89626124
Blood pressure diastolic abnormal 65.19 10.06 404 983110 19477 89625456
Psychotic disorder 65.05 10.06 152 983362 31078 89613855
Diarrhoea 64.83 10.06 9070 974444 930120 88714813
Vomiting 64.64 10.06 7529 975985 780764 88864169
Joint range of motion decreased 64.39 10.06 1928 981586 133715 89511218
Blood pressure systolic abnormal 63.99 10.06 396 983118 19082 89625851
Stevens-Johnson syndrome 63.60 10.06 140 983374 29236 89615697
Blood creatinine increased 63.28 10.06 749 982765 100637 89544296
Acute generalised exanthematous pustulosis 63.08 10.06 35 983479 13668 89631265
Myoclonus 62.88 10.06 69 983445 19099 89625834
Ascites 62.78 10.06 285 983229 47455 89597478
Facet joint syndrome 62.78 10.06 1454 982060 96935 89547998
Toxic skin eruption 62.16 10.06 48 983466 15726 89629207
Disability assessment scale score increased 62.04 10.06 134 983380 3797 89641136
Cerebral haemorrhage 61.99 10.06 181 983333 34341 89610592
Eosinophilia 61.76 10.06 136 983378 28397 89616536
Akathisia 61.58 10.06 22 983492 11137 89633796
Prescribed overdose 61.45 10.06 1440 982074 96185 89548748
Live birth 61.11 10.06 1202 982312 77905 89567028
Swollen tongue 60.64 10.06 274 983240 45682 89599251
Blood pressure decreased 60.57 10.06 520 982994 74375 89570558
Gamma-glutamyltransferase increased 60.43 10.06 210 983304 37742 89607191
Dysphagia 59.94 10.06 857 982657 111421 89533512
Carpal tunnel syndrome 59.89 10.06 455 983059 23473 89621460
Post transplant lymphoproliferative disorder 59.67 10.06 4 983510 6945 89637988
Hypomania 59.53 10.06 12 983502 8885 89636048
Pancreatitis acute 59.41 10.06 166 983348 31949 89612984
Face oedema 58.38 10.06 102 983412 23216 89621717
Disturbance in attention 57.99 10.06 288 983226 46821 89598112
Myocardial infarction 57.95 10.06 805 982709 105167 89539766
Coeliac disease 57.73 10.06 739 982775 43871 89601062
Infection 57.64 10.06 4620 978894 357474 89287459
Mucosal inflammation 57.60 10.06 377 983137 57248 89587685
Joint effusion 57.57 10.06 389 983125 19321 89625612
Proteinuria 57.31 10.06 103 983411 23188 89621745
Transplant rejection 56.72 10.06 34 983480 12724 89632209
Hepatotoxicity 56.57 10.06 280 983234 45562 89599371
Inflammation 56.49 10.06 2424 981090 176168 89468765
Blood glucose increased 56.28 10.06 712 982802 94534 89550399
Bronchopulmonary aspergillosis 55.61 10.06 27 983487 11371 89633562
Sensitisation 55.54 10.06 133 983381 4042 89640891
Diabetes mellitus inadequate control 55.20 10.06 73 983441 18611 89626322
Arthritis 54.97 10.06 2280 981234 165035 89479898
Cardiac failure congestive 54.94 10.06 747 982767 97947 89546986
Haemophagocytic lymphohistiocytosis 54.86 10.06 52 983462 15407 89629526
Blood pressure fluctuation 54.78 10.06 836 982678 51577 89593356
Disease recurrence 54.30 10.06 217 983297 37436 89607497
Hemiparesis 54.15 10.06 171 983343 31648 89613285
Respiratory distress 53.95 10.06 228 983286 38718 89606215
Aggression 53.79 10.06 132 983382 26536 89618397
Femur fracture 53.68 10.06 749 982765 45333 89599600
Pulmonary oedema 52.48 10.06 426 983088 61654 89583279
Interstitial lung disease 52.20 10.06 553 982961 75852 89569081
Hypomagnesaemia 52.02 10.06 204 983310 35384 89609549
Chronic kidney disease 51.88 10.06 325 983189 49866 89595067
Cardiogenic shock 51.03 10.06 119 983395 24349 89620584
Withdrawal syndrome 50.72 10.06 105 983409 22419 89622514
Dystonia 50.42 10.06 65 983449 16754 89628179
Aphasia 50.28 10.06 266 983248 42546 89602387
Personality disorder 50.15 10.06 37 983477 12407 89632526
Acute myeloid leukaemia 50.14 10.06 92 983422 20548 89624385
Ventricular fibrillation 50.12 10.06 47 983467 13997 89630936
Nasal polyps 49.78 10.06 28 983486 10852 89634081
Myocarditis 49.51 10.06 46 983468 13760 89631173
Ejection fraction 49.09 10.06 104 983410 2907 89642026
Abnormal behaviour 48.86 10.06 108 983406 22520 89622413
Bronchospasm 48.81 10.06 94 983420 20615 89624318
Lip dry 48.73 10.06 1438 982076 99517 89545416
Food allergy 48.65 10.06 456 983058 25022 89619911
Restlessness 48.32 10.06 211 983303 35509 89609424
Obesity 48.02 10.06 1492 982022 104015 89540918
Obstructive airways disorder 47.64 10.06 134 983380 25735 89619198
Paradoxical drug reaction 47.58 10.06 4 983510 5762 89639171
Stress cardiomyopathy 47.30 10.06 45 983469 13310 89631623
Foot deformity 47.30 10.06 910 982604 58741 89586192
Anxiety 47.06 10.06 2816 980698 306956 89337977
Cardiotoxicity 47.02 10.06 33 983481 11356 89633577
Metastases to lung 46.71 10.06 63 983451 15928 89629005
Arrhythmia 46.44 10.06 269 983245 42063 89602870
Polycystic ovaries 46.35 10.06 151 983363 5503 89639430
Vision blurred 46.30 10.06 880 982634 109413 89535520
Body temperature increased 46.29 10.06 712 982802 43998 89600935
Pulmonary embolism 46.05 10.06 1074 982440 129746 89515187
Cerebral infarction 45.92 10.06 142 983372 26454 89618479
Cytopenia 45.84 10.06 74 983440 17375 89627558
Deep vein thrombosis postoperative 45.65 10.06 1048 982466 69761 89575172
Melaena 45.60 10.06 208 983306 34589 89610344
Abortion spontaneous 45.40 10.06 832 982682 53224 89591709
Dyskinesia 45.17 10.06 223 983291 36311 89608622
Peripheral venous disease 45.14 10.06 1212 982302 82709 89562224
Mania 45.07 10.06 52 983462 14072 89630861
Tachypnoea 44.95 10.06 103 983411 21206 89623727
Hemiplegia 44.88 10.06 66 983448 16094 89628839
Mental status changes 44.81 10.06 292 983222 44387 89600546
Platelet count decreased 44.52 10.06 1138 982376 135831 89509102
Ischaemic stroke 44.49 10.06 110 983404 22056 89622877
Second primary malignancy 44.28 10.06 29 983485 10349 89634584
Urinary retention 44.05 10.06 235 983279 37509 89607424
Sinus tachycardia 43.91 10.06 160 983354 28353 89616580
Wound infection 43.85 10.06 1487 982027 104915 89540018
Atrioventricular block complete 43.82 10.06 26 983488 9785 89635148
Neuroleptic malignant syndrome 43.56 10.06 60 983454 15036 89629897
Febrile bone marrow aplasia 43.22 10.06 26 983488 9712 89635221
Muscle rigidity 43.20 10.06 55 983459 14254 89630679
Pulmonary fibrosis 43.20 10.06 1498 982016 106005 89538928
Haemorrhage intracranial 43.02 10.06 61 983453 15101 89629832
Septic shock 42.96 10.06 648 982866 83512 89561421
Juvenile idiopathic arthritis 42.84 10.06 117 983397 3860 89641073
Atrial fibrillation 42.39 10.06 1114 982400 132497 89512436
Toxic epidermal necrolysis 42.29 10.06 195 983319 32333 89612600
Circulatory collapse 42.26 10.06 134 983380 24770 89620163
Pleural effusion 42.09 10.06 910 982604 111081 89533852
Acute graft versus host disease 41.97 10.06 5 983509 5463 89639470
Skin exfoliation 41.88 10.06 503 983011 67410 89577523
Pulmonary arterial hypertension 41.63 10.06 145 983369 26042 89618891
Neurologic neglect syndrome 41.60 10.06 22 983492 8825 89636108
Sciatica 41.57 10.06 1416 982098 99966 89544967
Asthma-chronic obstructive pulmonary disease overlap syndrome 41.54 10.06 3 983511 4896 89640037
Hallucination, visual 41.51 10.06 121 983393 22971 89621962
Epstein-Barr virus infection 41.37 10.06 31 983483 10313 89634620
Muscle twitching 41.23 10.06 130 983384 24072 89620861
Gastrointestinal disorder 40.96 10.06 3276 980238 253411 89391522
Cognitive disorder 40.94 10.06 519 982995 68888 89576045
Acute respiratory distress syndrome 40.94 10.06 166 983348 28520 89616413
Rash maculo-papular 40.80 10.06 268 983246 40665 89604268
Angina pectoris 40.77 10.06 253 983261 38907 89606026
Agranulocytosis 40.26 10.06 219 983295 34783 89610150
Device use error 40.25 10.06 14 983500 7207 89637726
Tumour lysis syndrome 40.18 10.06 37 983477 11115 89633818
Metastases to central nervous system 40.16 10.06 81 983433 17461 89627472
Acute graft versus host disease in skin 40.08 10.06 3 983511 4753 89640180
Loss of personal independence in daily activities 39.88 10.06 1833 981681 134272 89510661
Joint laxity 39.68 10.06 88 983426 2540 89642393
Red blood cell sedimentation rate increased 39.46 10.06 1175 982339 81420 89563513
Carotid artery thrombosis 39.35 10.06 25 983489 9067 89635866
Multiple sclerosis relapse 39.30 10.06 370 983144 51935 89592998
Asphyxia 39.20 10.06 14 983500 7089 89637844
Coagulopathy 39.04 10.06 126 983388 23163 89621770
Aspergillus infection 38.89 10.06 36 983478 10787 89634146
Graft versus host disease 38.66 10.06 20 983494 8124 89636809
Cerebrovascular accident 38.40 10.06 1033 982481 122500 89522433
Blood pressure systolic increased 38.38 10.06 866 982648 57479 89587454
Gastrointestinal haemorrhage 38.20 10.06 719 982795 89529 89555404
Autoimmune disorder 38.09 10.06 1097 982417 75647 89569286
Drug dose omission by device 37.99 10.06 33 983481 10198 89634735
Anuria 37.85 10.06 64 983450 14754 89630179
Jaundice cholestatic 37.78 10.06 32 983482 10011 89634922
Affect lability 37.55 10.06 88 983426 17975 89626958
Osteoporosis 37.52 10.06 1340 982174 95191 89549742
Joint destruction 37.48 10.06 260 983254 13027 89631906
BK virus infection 37.45 10.06 3 983511 4495 89640438
Cytomegalovirus infection reactivation 37.26 10.06 19 983495 7781 89637152
Haematoma 37.26 10.06 259 983255 38789 89606144
Jaundice 37.10 10.06 204 983310 32313 89612620
Pain in extremity 37.08 10.06 5502 978012 445027 89199906
Swelling face 37.00 10.06 640 982874 80712 89564221
Multiple fractures 37.00 10.06 203 983311 9359 89635574
Pathogen resistance 36.96 10.06 21 983493 8094 89636839
Substance abuse 36.79 10.06 7 983507 5399 89639534
Road traffic accident 36.57 10.06 1472 982042 106154 89538779
Flushing 36.54 10.06 708 982806 87783 89557150
Rebound effect 36.41 10.06 29 983485 9355 89635578
Musculoskeletal pain 36.25 10.06 2237 981277 169014 89475919
Pain in jaw 36.24 10.06 339 983175 47646 89597287
Colitis 36.23 10.06 537 982977 69405 89575528
Genital haemorrhage 36.21 10.06 25 983489 8677 89636256
COVID-19 36.13 10.06 1481 982033 167362 89477571
Nightmare 36.10 10.06 118 983396 21607 89623326
Bradyphrenia 35.69 10.06 19 983495 7593 89637340
Labelled drug-drug interaction medication error 35.42 10.06 65 983449 14517 89630416
Speech disorder 35.31 10.06 320 983194 45265 89599668
Vertigo 35.13 10.06 539 982975 69272 89575661
Motor dysfunction 35.13 10.06 100 983414 19130 89625803
Dizziness 34.86 10.06 5741 977773 583543 89061390
Muscle spasticity 34.86 10.06 558 982956 34764 89610169
Transaminases increased 34.84 10.06 248 983266 36944 89607989
Polyarthritis 34.82 10.06 328 983186 18022 89626911
Basal cell carcinoma 34.67 10.06 532 982982 32857 89612076
Lip swelling 34.47 10.06 261 983253 38349 89606584
Foetal death 34.28 10.06 360 983154 20363 89624570
Respiratory acidosis 34.22 10.06 23 983491 8096 89636837
Multiple-drug resistance 34.18 10.06 21 983493 7755 89637178
C-reactive protein increased 34.16 10.06 2346 981168 179043 89465890
Tubulointerstitial nephritis 34.10 10.06 150 983364 25193 89619740
Dry mouth 34.05 10.06 2377 981137 181682 89463251
Oliguria 34.02 10.06 39 983475 10585 89634348
Erythema multiforme 34.02 10.06 50 983464 12196 89632737
Diabetes mellitus 33.98 10.06 497 983017 64378 89580555
Psychomotor hyperactivity 33.98 10.06 54 983460 12759 89632174
Haemorrhage 33.75 10.06 539 982975 68830 89576103
Cough 33.68 10.06 3497 980017 365465 89279468
Pemphigoid 33.66 10.06 29 983485 8997 89635936
Bone marrow failure 33.63 10.06 208 983306 32013 89612920
Accidental overdose 33.57 10.06 175 983339 28098 89616835
Dislocation of vertebra 33.23 10.06 819 982695 55149 89589784
Constipation 33.08 10.06 2606 980908 277789 89367144
Drug hypersensitivity 32.93 10.06 4468 979046 459141 89185792
Gestational diabetes 32.81 10.06 212 983302 10370 89634563
Subarachnoid haemorrhage 32.78 10.06 93 983421 17811 89627122
Cardiomyopathy 32.71 10.06 111 983403 20095 89624838
Ketoacidosis 32.68 10.06 10 983504 5585 89639348
Hyperhidrosis 32.58 10.06 1180 982334 135125 89509808
Adjustment disorder 32.42 10.06 34 983480 9608 89635325
Pericardial effusion 32.41 10.06 250 983264 36583 89608350
Hypercholesterolaemia 32.25 10.06 1371 982143 99521 89545412
Blood pressure diastolic decreased 31.64 10.06 437 983077 26389 89618544
Upper respiratory tract infection 31.34 10.06 1698 981816 126620 89518313
Clostridium difficile colitis 31.32 10.06 166 983348 26540 89618393
Acute respiratory failure 31.22 10.06 306 983208 42612 89602321
Pallor 30.95 10.06 230 983284 33935 89610998
Product dose omission issue 30.93 10.06 2734 980780 288953 89355980
International normalised ratio increased 30.90 10.06 346 983168 46970 89597963
Breast cancer stage III 30.81 10.06 1164 982350 83283 89561650
Immune reconstitution inflammatory syndrome 30.79 10.06 19 983495 7000 89637933
Bone erosion 30.62 10.06 773 982741 52248 89592685
Neck deformity 30.49 10.06 71 983443 2118 89642815
Dry skin 30.45 10.06 725 982789 87348 89557585
Product prescribing error 30.23 10.06 197 983317 29948 89614985
Adverse event 30.13 10.06 1561 981953 115857 89529076
Cytomegalovirus viraemia 30.00 10.06 23 983491 7563 89637370
Dyspnoea exertional 29.95 10.06 578 982936 71710 89573223
Arterial occlusive disease 29.77 10.06 56 983458 12390 89632543
Bradypnoea 29.71 10.06 7 983507 4651 89640282
Lethargy 29.59 10.06 494 983020 62645 89582288
Device dislocation 29.46 10.06 210 983304 31272 89613661
Electrocardiogram QRS complex prolonged 29.41 10.06 22 983492 7326 89637607
Intervertebral disc degeneration 29.00 10.06 301 983213 16973 89627960
Pulmonary hypertension 28.95 10.06 308 983206 42215 89602718
Injection site reaction 28.92 10.06 1249 982265 90831 89554102
Haemodynamic instability 28.80 10.06 52 983462 11687 89633246
Right ventricular failure 28.77 10.06 109 983405 19096 89625837
Sinus bradycardia 28.22 10.06 92 983422 16860 89628073
Device related infection 28.21 10.06 164 983350 25622 89619311
Transplant dysfunction 28.16 10.06 11 983503 5271 89639662
Cyanosis 28.13 10.06 112 983402 19343 89625590
Tardive dyskinesia 28.11 10.06 47 983467 10883 89634050
Miosis 28.07 10.06 37 983477 9447 89635486
Myopathy 27.99 10.06 66 983448 13452 89631481
Generalised tonic-clonic seizure 27.92 10.06 243 983271 34660 89610273
Aspartate aminotransferase increased 27.91 10.06 877 982637 102060 89542873
Gait inability 27.89 10.06 1896 981618 144560 89500373
Abdominal pain 27.82 10.06 3816 979698 391905 89253028
Product administered to patient of inappropriate age 27.76 10.06 8 983506 4645 89640288
Acute pulmonary oedema 27.72 10.06 38 983476 9542 89635391
Heart rate decreased 27.72 10.06 769 982745 52736 89592197
Bronchopulmonary aspergillosis allergic 27.57 10.06 4 983510 3762 89641171
Total lung capacity increased 27.54 10.06 10 983504 5011 89639922
Maternal drugs affecting foetus 27.52 10.06 120 983394 5035 89639898
Lymphopenia 27.52 10.06 141 983373 22740 89622193
Skin toxicity 27.52 10.06 20 983494 6759 89638174
Product administration error 27.36 10.06 171 983343 26252 89618681
Hyperbilirubinaemia 27.32 10.06 70 983444 13866 89631067
Pulseless electrical activity 27.31 10.06 34 983480 8898 89636035
Blood lactic acid increased 27.28 10.06 33 983481 8745 89636188
Brain oedema 27.14 10.06 97 983417 17288 89627645
Hallucination, auditory 27.08 10.06 86 983428 15889 89629044
Hyperthermia 26.99 10.06 44 983470 10291 89634642
Schizoaffective disorder 26.98 10.06 11 983503 5136 89639797
Foetal exposure during pregnancy 26.76 10.06 633 982881 42342 89602591
Ear infection 26.72 10.06 967 982547 68808 89576125
Joint stiffness 26.65 10.06 1068 982446 76974 89567959
White blood cell count decreased 26.63 10.06 1512 982002 165597 89479336
Intramedullary rod insertion 26.57 10.06 67 983447 2105 89642828
Product preparation error 26.50 10.06 44 983470 10217 89634716
Irritability 26.48 10.06 253 983261 35409 89609524
General physical health deterioration 26.44 10.06 4313 979201 350802 89294131
Alanine aminotransferase increased 26.39 10.06 1033 982481 117305 89527628
Feeling abnormal 26.31 10.06 1515 981999 165720 89479213
Hepatitis acute 26.02 10.06 49 983465 10838 89634095
Polyuria 25.98 10.06 43 983471 9997 89634936
Treatment noncompliance 25.81 10.06 400 983114 51327 89593606
Complication of device insertion 25.81 10.06 46 983468 10390 89634543
Haemoptysis 25.77 10.06 234 983280 33086 89611847
Sexual dysfunction 25.62 10.06 10 983504 4794 89640139
Small for dates baby 25.56 10.06 115 983399 4892 89640041
Sensory loss 25.54 10.06 105 983409 17970 89626963
Anti-neutrophil cytoplasmic antibody positive vasculitis 25.47 10.06 6 983508 3987 89640946
Graft versus host disease in gastrointestinal tract 25.35 10.06 8 983506 4380 89640553
Depressed mood 25.18 10.06 388 983126 49834 89595099
Emotional distress 25.18 10.06 265 983249 36397 89608536
Palmoplantar keratoderma 25.05 10.06 4 983510 3503 89641430
Condition aggravated 25.03 10.06 7038 976476 588507 89056426
Blood alkaline phosphatase increased 24.95 10.06 369 983145 47710 89597223
Device breakage 24.95 10.06 74 983440 13970 89630963
Generalised oedema 24.90 10.06 114 983400 18939 89625994
Dyspepsia 24.83 10.06 2485 981029 195675 89449258
Adjustment disorder with depressed mood 24.62 10.06 798 982716 55955 89588978
Paralysis 24.60 10.06 55 983459 11423 89633510
Caesarean section 24.57 10.06 309 983205 18268 89626665
Diabetes insipidus 24.50 10.06 3 983511 3209 89641724
Intentional product misuse 24.39 10.06 763 982751 88841 89556092
Exostosis 24.33 10.06 752 982762 52382 89592551
Sleep terror 24.30 10.06 9 983505 4455 89640478
Nodule 24.28 10.06 416 983098 26270 89618663
Lower limb fracture 24.27 10.06 1142 982372 83871 89561062
Hospitalisation 24.23 10.06 1139 982375 126961 89517972
Graft versus host disease in skin 24.17 10.06 6 983508 3847 89641086
Wheelchair user 24.16 10.06 156 983358 7629 89637304
Eye pruritus 24.16 10.06 200 983314 28827 89616106
Nephrectomy 24.12 10.06 61 983453 1920 89643013
Adenovirus infection 24.03 10.06 10 983504 4612 89640321
Pneumonitis 23.97 10.06 336 983178 43834 89601099
Pyrexia 23.93 10.06 6592 976922 653893 88991040
Low turnover osteopathy 23.92 10.06 100 983414 4118 89640815
Bradykinesia 23.89 10.06 23 983491 6765 89638168
Prescribed underdose 23.88 10.06 1019 982495 74000 89570933
Premature labour 23.86 10.06 236 983278 13140 89631793
Forced expiratory volume decreased 23.75 10.06 17 983497 5791 89639142
Mental disorder 23.69 10.06 230 983284 32088 89612845
Dysphonia 23.58 10.06 513 983001 62571 89582362
Abdominal pain upper 23.49 10.06 4029 979485 328645 89316288
Gangrene 23.49 10.06 67 983447 12809 89632124
Hepatitis B reactivation 23.40 10.06 7 983507 3967 89640966
Rotator cuff repair 23.32 10.06 69 983445 2385 89642548
Chronic graft versus host disease 23.12 10.06 8 983506 4131 89640802
Onychomycosis 23.11 10.06 550 982964 36826 89608107
Hyperlactacidaemia 23.09 10.06 8 983506 4128 89640805
Product storage error 23.08 10.06 127 983387 20114 89624819
Device issue 23.03 10.06 207 983307 29330 89615603
Bone pain 22.90 10.06 505 983009 61478 89583455
Shock haemorrhagic 22.87 10.06 63 983451 12182 89632751
Ileus 22.83 10.06 97 983417 16449 89628484
Hypocalcaemia 22.74 10.06 323 983191 42045 89602888
Subdural haematoma 22.71 10.06 98 983416 16547 89628386
Acidosis 22.70 10.06 67 983447 12669 89632264
Pulmonary congestion 22.67 10.06 121 983393 19312 89625621
Hypernatraemia 22.66 10.06 42 983472 9345 89635588
Atrial tachycardia 22.64 10.06 19 983495 5971 89638962
Ataxia 22.37 10.06 110 983404 17932 89627001
Complication of device removal 22.24 10.06 21 983493 6234 89638699
Dissociation 22.22 10.06 24 983490 6691 89638242
Blood pressure diastolic increased 22.20 10.06 226 983288 12680 89632253
Immune effector cell-associated neurotoxicity syndrome 22.16 10.06 18 983496 5750 89639183
Hyperprolactinaemia 22.09 10.06 16 983498 5417 89639516
Renal injury 22.02 10.06 49 983465 10194 89634739
Deafness transitory 21.91 10.06 60 983454 1983 89642950
Hallucinations, mixed 21.86 10.06 19 983495 5870 89639063
Toxic encephalopathy 21.83 10.06 38 983476 8661 89636272
Skin haemorrhage 21.81 10.06 139 983375 21241 89623692
Delusion 21.75 10.06 77 983437 13763 89631170
Tenderness 21.68 10.06 411 983103 26457 89618476
Hypertension 21.67 10.06 5435 978079 452097 89192836
Joint noise 21.62 10.06 114 983400 5176 89639757
Smear cervix abnormal 21.48 10.06 79 983435 3063 89641870
Acute coronary syndrome 21.44 10.06 54 983460 10759 89634174
Tinnitus 21.27 10.06 334 983180 42768 89602165
Hypoaesthesia 21.27 10.06 3797 979717 310413 89334520
Respiratory disorder 21.21 10.06 883 982631 63933 89581000
Mood altered 20.99 10.06 105 983409 17039 89627894
Systemic candida 20.97 10.06 14 983500 4945 89639988
Hepatitis cholestatic 20.94 10.06 38 983476 8523 89636410
Drug tolerance decreased 20.85 10.06 476 983038 31654 89613279
Incorrect dose administered 20.78 10.06 675 982839 78255 89566678
Foot operation 20.78 10.06 168 983346 8833 89636100
Device malfunction 20.58 10.06 138 983376 20839 89624094
Pruritus genital 20.47 10.06 12 983502 4546 89640387
Drug effective for unapproved indication 20.41 10.06 34 983480 7884 89637049
Ventricular septal defect 20.39 10.06 114 983400 5293 89639640
Cardiac failure acute 20.37 10.06 64 983450 11865 89633068
Presyncope 20.21 10.06 234 983280 31571 89613362
Limb deformity 20.18 10.06 94 983420 4058 89640875
Paranoia 20.16 10.06 72 983442 12836 89632097
Gastroenteritis viral 20.10 10.06 451 983063 29904 89615029
Maternal exposure before pregnancy 20.08 10.06 198 983316 11015 89633918
Hypoglycaemic coma 20.08 10.06 4 983510 2986 89641947
Orthostatic hypotension 20.01 10.06 326 983188 41501 89603432
Ejection fraction abnormal 19.95 10.06 66 983448 2425 89642508
Epistaxis 19.87 10.06 739 982775 84386 89560547
Aspiration 19.85 10.06 95 983419 15598 89629335
Acute myocardial infarction 19.80 10.06 263 983251 34627 89610306
Body temperature decreased 19.80 10.06 366 983148 23450 89621483
Bezoar 19.80 10.06 3 983511 2731 89642202
Renal tubular necrosis 19.67 10.06 86 983428 14469 89630464
Pulmonary toxicity 19.60 10.06 62 983452 11469 89633464
Laryngitis 19.58 10.06 704 982810 50049 89594884
C-reactive protein 19.52 10.06 462 983052 30905 89614028
Laryngospasm 19.39 10.06 6 983508 3327 89641606
Hypertransaminasaemia 19.33 10.06 97 983417 15728 89629205
Bacteraemia 19.32 10.06 152 983362 22148 89622785
Peripheral sensory neuropathy 19.28 10.06 45 983469 9205 89635728
Asthenia 19.24 10.06 5328 978186 528423 89116510
Klebsiella infection 19.21 10.06 53 983461 10244 89634689
Laryngeal oedema 19.21 10.06 28 983486 6853 89638080
Panic attack 19.17 10.06 188 983326 26177 89618756
Retinitis 19.15 10.06 550 982964 37908 89607025
Hypogammaglobulinaemia 19.14 10.06 56 983458 10618 89634315
Acute chest syndrome 19.12 10.06 40 983474 1108 89643825
Throat tightness 19.10 10.06 216 983298 29268 89615665
Inappropriate schedule of product administration 19.01 10.06 1385 982129 148548 89496385
Device leakage 18.96 10.06 51 983463 9940 89634993
Maternal exposure during delivery 18.93 10.06 9 983505 3837 89641096
Leukocytosis 18.93 10.06 230 983284 30760 89614173
Glomerular filtration rate decreased 18.89 10.06 107 983407 16825 89628108
Premature rupture of membranes 18.89 10.06 114 983400 5444 89639489
Lupus vulgaris 18.88 10.06 631 982883 44428 89600505
Haematemesis 18.86 10.06 255 983259 33471 89611462
Disturbance in social behaviour 18.84 10.06 11 983503 4177 89640756
Fracture delayed union 18.83 10.06 65 983449 2441 89642492
Disability 18.75 10.06 577 982937 40168 89604765
Malaise 18.72 10.06 5879 977635 580107 89064826
Crying 18.59 10.06 183 983331 25462 89619471
Exposure via skin contact 18.59 10.06 57 983457 10648 89634285
Tuberculosis 18.46 10.06 213 983301 12336 89632597
Hyperammonaemia 18.42 10.06 26 983488 6449 89638484
Pancreatitis 18.42 10.06 597 982917 69229 89575704
Joint dislocation 18.35 10.06 623 982891 43959 89600974
Breast cancer female 18.32 10.06 91 983423 14795 89630138
Enthesopathy 18.30 10.06 169 983345 9235 89635698
Pseudomonas infection 18.22 10.06 91 983423 14774 89630159
Maternal exposure timing unspecified 18.16 10.06 344 983170 22139 89622794
Sleep disorder 18.15 10.06 2434 981080 195596 89449337
Sputum discoloured 18.13 10.06 138 983376 20253 89624680
Skin plaque 18.13 10.06 52 983462 9923 89635010
Immune-mediated enterocolitis 18.09 10.06 15 983499 4742 89640191
Dysgeusia 18.07 10.06 433 983081 52127 89592806
Latent tuberculosis 18.02 10.06 72 983442 2904 89642029
Rhinovirus infection 17.92 10.06 23 983491 5940 89638993
Dysmorphism 17.92 10.06 65 983449 2503 89642430
Product substitution issue 17.90 10.06 118 983396 17890 89627043
Eosinophilic granulomatosis with polyangiitis 17.81 10.06 3 983511 2527 89642406
Nephropathy toxic 17.74 10.06 74 983440 12614 89632319
Varicella zoster virus infection 17.71 10.06 10 983504 3867 89641066
Rales 17.67 10.06 100 983414 15727 89629206
Abortion incomplete 17.66 10.06 6 983508 3134 89641799
Pneumonia viral 17.54 10.06 44 983470 8779 89636154
Lymphocyte count decreased 17.50 10.06 271 983243 34779 89610154
Brain injury 17.48 10.06 36 983478 7702 89637231
Pneumonia 17.47 10.06 6440 977074 631619 89013314
Facial paralysis 17.42 10.06 98 983416 15436 89629497
Enterocolitis 17.41 10.06 57 983457 10433 89634500
Body tinea 17.28 10.06 57 983457 2091 89642842
Onychomadesis 17.25 10.06 636 982878 45362 89599571
Blood lactate dehydrogenase increased 17.18 10.06 189 983325 25743 89619190
Hyperuricaemia 17.18 10.06 29 983485 6690 89638243
Complication associated with device 17.11 10.06 132 983382 19317 89625616
Spinal stenosis 17.10 10.06 275 983239 17149 89627784
Blindness 17.07 10.06 195 983319 26373 89618560
Affective disorder 16.99 10.06 37 983477 7756 89637177
Eating disorder 16.90 10.06 209 983305 27864 89617069
Hepatitis fulminant 16.86 10.06 11 983503 3934 89640999
Hepatic cirrhosis 16.85 10.06 844 982670 62409 89582524
Potentiating drug interaction 16.85 10.06 22 983492 5640 89639293
Salivary hypersecretion 16.81 10.06 47 983467 9045 89635888
Hyperreflexia 16.77 10.06 29 983485 6628 89638305
Malignant mediastinal neoplasm 16.77 10.06 43 983471 1365 89643568
Illness 16.68 10.06 723 982791 81246 89563687
Neutrophilia 16.64 10.06 23 983491 5755 89639178
Amenorrhoea 16.62 10.06 68 983446 11654 89633279
X-ray abnormal 16.54 10.06 626 982888 44798 89600135
Spinal osteoarthritis 16.53 10.06 296 983218 18852 89626081
Hypervolaemia 16.45 10.06 253 983261 32504 89612429
Chills 16.43 10.06 1221 982293 130760 89514173
Hypotonia 16.38 10.06 66 983448 11360 89633573
Anti-cyclic citrullinated peptide antibody 16.36 10.06 399 983115 26822 89618111
Endophthalmitis 16.35 10.06 16 983498 4669 89640264
Colitis microscopic 16.29 10.06 64 983450 11095 89633838
Pulmonary alveolar haemorrhage 16.17 10.06 25 983489 5973 89638960
Neck mass 16.10 10.06 84 983430 3798 89641135
Nystagmus 16.01 10.06 34 983480 7193 89637740
Injection site erythema 15.99 10.06 1259 982255 97243 89547690
Fear 15.98 10.06 110 983404 16512 89628421
Intracranial pressure increased 15.98 10.06 31 983483 6780 89638153
Ileus paralytic 15.93 10.06 19 983495 5066 89639867
Drug ineffective 15.90 10.06 14342 969172 1369956 88274977
Systemic inflammatory response syndrome 15.87 10.06 29 983485 6487 89638446
Pregnancy with contraceptive device 15.79 10.06 19 983495 5047 89639886
Hyperpyrexia 15.77 10.06 17 983497 4744 89640189
Personality change 15.76 10.06 35 983479 7286 89637647
Electrolyte imbalance 15.76 10.06 173 983341 23572 89621361
Product prescribing issue 15.70 10.06 40 983474 7939 89636994
Eczema 15.68 10.06 445 983069 52425 89592508
Catheter site erythema 15.64 10.06 18 983496 4876 89640057
Erythema 15.58 10.06 2215 981299 227031 89417902
Bone density increased 15.52 10.06 32 983482 877 89644056
Eosinophil count increased 15.51 10.06 81 983433 13000 89631933
Dactylitis 15.51 10.06 83 983431 3790 89641143
Skin burning sensation 15.48 10.06 137 983377 19474 89625459
Developmental hip dysplasia 15.48 10.06 45 983469 1540 89643393
Synovial cyst 15.34 10.06 195 983319 11557 89633376
Catheter site pain 15.28 10.06 23 983491 5556 89639377
Cell death 15.27 10.06 7 983507 3048 89641885
Atrioventricular block 15.26 10.06 47 983467 8768 89636165
Psychotic symptom 15.19 10.06 3 983511 2253 89642680
Epstein-Barr virus associated lymphoproliferative disorder 15.16 10.06 5 983509 2662 89642271
Dermatitis bullous 15.16 10.06 59 983455 10257 89634676
Pulmonary haemorrhage 15.13 10.06 41 983473 7972 89636961
Glomerular filtration rate increased 15.11 10.06 53 983461 2007 89642926
Amylase increased 15.07 10.06 34 983480 7038 89637895
Type 1 diabetes mellitus 15.05 10.06 18 983496 4794 89640139
Endodontic procedure 14.97 10.06 76 983438 3399 89641534
Intestinal ischaemia 14.93 10.06 48 983466 8835 89636098
Lupus vasculitis 14.90 10.06 25 983489 583 89644350
Blood pressure inadequately controlled 14.89 10.06 28 983486 6196 89638737
Hyperthyroidism 14.86 10.06 127 983387 18183 89626750
Respiration abnormal 14.85 10.06 41 983473 7922 89637011
Cystitis haemorrhagic 14.84 10.06 23 983491 5490 89639443
Hepatocellular carcinoma 14.81 10.06 4 983510 2424 89642509
Ventricular arrhythmia 14.80 10.06 15 983499 4306 89640627
Type I hypersensitivity 14.72 10.06 14 983500 4141 89640792
Respiratory tract congestion 14.70 10.06 209 983305 27201 89617732
Pain of skin 14.69 10.06 108 983406 15974 89628959
Wrong product administered 14.64 10.06 39 983475 7626 89637307
Neutropenic colitis 14.63 10.06 14 983500 4129 89640804
End stage renal disease 14.63 10.06 46 983468 8525 89636408
Breast cancer metastatic 14.62 10.06 100 983414 15032 89629901
Cleft lip and palate 14.58 10.06 28 983486 728 89644205
Lupus-like syndrome 14.55 10.06 659 982855 48187 89596746
Immune thrombocytopenia 14.45 10.06 85 983429 13241 89631692
Hypophosphataemia 14.43 10.06 98 983416 14756 89630177
Body height below normal 14.39 10.06 54 983460 2114 89642819
Localised infection 14.32 10.06 471 983043 33091 89611842
Nocardiosis 14.30 10.06 5 983509 2565 89642368
Heart rate increased 14.30 10.06 1043 982471 111859 89533074
Skin cancer 14.27 10.06 216 983298 13303 89631630
Product monitoring error 14.21 10.06 17 983497 4527 89640406
Foetal anticonvulsant syndrome 14.21 10.06 26 983488 651 89644282
Breast cancer stage I 14.17 10.06 55 983459 9569 89635364
Pneumatosis intestinalis 14.14 10.06 10 983504 3427 89641506
Stillbirth 14.10 10.06 133 983381 7310 89637623
Nail disorder 14.10 10.06 780 982734 58287 89586646
Placental disorder 14.09 10.06 44 983470 1567 89643366
Metastases to skin 14.08 10.06 3 983511 2137 89642796
Gallbladder polyp 14.08 10.06 32 983482 939 89643994
Atrial septal defect 14.07 10.06 144 983370 8090 89636843
Dermatitis exfoliative 14.06 10.06 24 983490 5512 89639421
Staphylococcal infection 14.03 10.06 409 983105 48030 89596903
Synovial disorder 14.00 10.06 69 983445 3049 89641884
Gene mutation 13.99 10.06 3 983511 2127 89642806
Subacute cutaneous lupus erythematosus 13.99 10.06 11 983503 3571 89641362
Nail operation 13.95 10.06 49 983465 1857 89643076
Colorectal cancer 13.93 10.06 13 983501 3880 89641053
Loose body in joint 13.88 10.06 40 983474 1362 89643571
Pyelonephritis 13.87 10.06 156 983358 21160 89623773
Cardiac failure chronic 13.86 10.06 25 983489 5621 89639312
Blepharospasm 13.79 10.06 735 982779 54710 89590223
Anaemia postoperative 13.77 10.06 54 983460 2159 89642774
Cardiac tamponade 13.77 10.06 25 983489 5607 89639326
Drug tolerance 13.75 10.06 272 983242 17644 89627289
Lung disorder 13.70 10.06 1842 981672 148041 89496892
Device deployment issue 13.68 10.06 20 983494 4889 89640044
Haematuria 13.67 10.06 282 983232 34655 89610278
Dependence 13.66 10.06 3 983511 2092 89642841
Persecutory delusion 13.64 10.06 9 983505 3199 89641734
Staphylococcal sepsis 13.58 10.06 54 983460 9329 89635604
Incorrect dose administered by device 13.56 10.06 26 983488 5711 89639222
Crystal nephropathy 13.55 10.06 35 983479 1116 89643817
Rheumatoid factor increased 13.55 10.06 57 983457 2354 89642579
Acute graft versus host disease in intestine 13.55 10.06 3 983511 2080 89642853
Bone density decreased 13.54 10.06 264 983250 17081 89627852
Chronic obstructive pulmonary disease 13.45 10.06 659 982855 73170 89571763
Hypoventilation 13.41 10.06 23 983491 5273 89639660
Tenosynovitis stenosans 13.38 10.06 81 983433 3872 89641061
Pneumocystis jirovecii pneumonia 13.36 10.06 160 983354 21456 89623477
Head injury 13.34 10.06 248 983266 30940 89613993
Vertebral osteophyte 13.33 10.06 22 983492 506 89644427
Kidney transplant rejection 13.33 10.06 20 983494 4837 89640096
Venoocclusive disease 13.28 10.06 5 983509 2450 89642483
Uterine perforation 13.28 10.06 40 983474 7514 89637419
Sneezing 13.25 10.06 236 983278 29633 89615300
Lymphoedema 13.23 10.06 91 983423 13662 89631271
Loss of employment 13.22 10.06 8 983506 2979 89641954
Rheumatoid lung 13.22 10.06 83 983431 4020 89640913
Troponin increased 13.21 10.06 87 983427 13194 89631739
Blood prolactin increased 13.18 10.06 12 983502 3625 89641308
Dermatitis acneiform 13.17 10.06 31 983483 6323 89638610
Embedded device 13.17 10.06 16 983498 4232 89640701
Rheumatoid nodule 13.16 10.06 299 983215 19867 89625066
Ankylosing spondylitis 13.16 10.06 208 983306 12925 89632008
Immunosuppressant drug level increased 13.11 10.06 19 983495 4661 89640272
Glycosylated haemoglobin increased 13.05 10.06 107 983407 15455 89629478
Physical deconditioning 13.05 10.06 4 983510 2231 89642702
Implant site pain 13.03 10.06 6 983508 2606 89642327
Congenital arterial malformation 13.02 10.06 17 983497 314 89644619
Infection susceptibility increased 13.01 10.06 80 983434 3846 89641087
Deep vein thrombosis 12.99 10.06 838 982676 90782 89554151
Drug screen positive 12.91 10.06 13 983501 3744 89641189
Dysuria 12.89 10.06 327 983187 39074 89605859
Blood test abnormal 12.86 10.06 308 983206 20644 89624289
Coordination abnormal 12.85 10.06 159 983355 21197 89623736
Hypertensive crisis 12.85 10.06 127 983387 17657 89627276
Immunisation 12.85 10.06 4 983510 2209 89642724
Blood potassium decreased 12.84 10.06 407 983107 47320 89597613
Antinuclear antibody positive 12.78 10.06 155 983359 9086 89635847
Gastrointestinal toxicity 12.76 10.06 56 983458 9411 89635522
Metastases to meninges 12.75 10.06 13 983501 3722 89641211
Neoplasm recurrence 12.74 10.06 10 983504 3249 89641684
International normalised ratio fluctuation 12.72 10.06 9 983505 3084 89641849
Diplopia 12.70 10.06 227 983287 28487 89616446
Breast feeding 12.70 10.06 29 983485 854 89644079
Impaired gastric emptying 12.70 10.06 84 983430 12725 89632208
Malignant melanoma 12.53 10.06 199 983315 12377 89632556
Oxalosis 12.48 10.06 8 983506 54 89644879
Inadequate analgesia 12.46 10.06 10 983504 3214 89641719
Cerebral haematoma 12.42 10.06 17 983497 4272 89640661
Skin papilloma 12.42 10.06 104 983410 5526 89639407
Aplasia 12.41 10.06 15 983499 3976 89640957
Synovial fluid analysis 12.40 10.06 62 983452 2756 89642177
Eyelid oedema 12.28 10.06 74 983440 11460 89633473
Catheter site haemorrhage 12.26 10.06 13 983501 3655 89641278
Central nervous system lesion 12.25 10.06 75 983439 11571 89633362
Gastrooesophageal reflux disease 12.22 10.06 2019 981495 164318 89480615
Infection reactivation 12.21 10.06 3 983511 1937 89642996
Metabolic disorder 12.12 10.06 41 983473 7429 89637504
Bone lesion 12.11 10.06 33 983481 6404 89638529
Steroid diabetes 12.09 10.06 6 983508 2496 89642437
Injection site pruritus 12.09 10.06 707 982807 53127 89591806
Crohn's disease 12.00 10.06 92 983422 4759 89640174
Hypercapnia 11.99 10.06 35 983479 6642 89638291
Cholangitis 11.94 10.06 39 983475 7143 89637790
Chorea 11.92 10.06 4 983510 2106 89642827
Pathological fracture 11.92 10.06 59 983455 9601 89635332
Arthritis infective 11.91 10.06 136 983378 7856 89637077
Apnoea 11.90 10.06 57 983457 9357 89635576
Oculogyric crisis 11.90 10.06 6 983508 2473 89642460
Clear cell renal cell carcinoma 11.89 10.06 41 983473 1539 89643394
Throat clearing 11.88 10.06 77 983437 3770 89641163
Lip oedema 11.88 10.06 20 983494 4619 89640314
Bronchial secretion retention 11.87 10.06 13 983501 3602 89641331
Nasal obstruction 11.87 10.06 58 983456 2554 89642379
Poor quality device used 11.86 10.06 5 983509 2288 89642645
Red blood cell count decreased 11.84 10.06 616 982898 45735 89599198
Cystoid macular oedema 11.83 10.06 4 983510 2096 89642837
Pneumonia fungal 11.81 10.06 38 983476 6993 89637940
Nervous system disorder 11.81 10.06 164 983350 21429 89623504
Brain abscess 11.81 10.06 8 983506 2804 89642129
Limb reduction defect 11.79 10.06 23 983491 605 89644328
Foot fracture 11.77 10.06 375 983139 26231 89618702
Cardiopulmonary failure 11.73 10.06 17 983497 4171 89640762
Hemianopia 11.67 10.06 4 983510 2078 89642855
Anosmia 11.67 10.06 61 983453 9787 89635146
Leukoencephalopathy 11.59 10.06 22 983492 4851 89640082
Brain death 11.58 10.06 16 983498 4005 89640928
Ankle arthroplasty 11.56 10.06 61 983453 2770 89642163
Hypertelorism 11.55 10.06 21 983493 523 89644410
Device use issue 11.49 10.06 14 983500 3699 89641234
Product residue present 11.46 10.06 18 983496 4273 89640660
Therapeutic response shortened 11.39 10.06 177 983337 22702 89622231
Tetany 11.33 10.06 7 983507 2577 89642356
Compartment syndrome 11.30 10.06 9 983505 2903 89642030
Hypoalbuminaemia 11.29 10.06 114 983400 15783 89629150
Cervical incompetence 11.29 10.06 23 983491 625 89644308
Amyloid arthropathy 11.28 10.06 42 983472 1638 89643295
Pulmonary function test abnormal 11.22 10.06 8 983506 2731 89642202
Skin lesion 11.20 10.06 314 983200 37051 89607882
Oedema peripheral 11.17 10.06 2553 980961 255362 89389571
Hereditary angioedema 11.10 10.06 58 983456 9307 89635626
Postoperative wound infection 11.05 10.06 206 983308 13220 89631713
Therapy interrupted 11.04 10.06 438 983076 49670 89595263
Retrognathia 11.01 10.06 21 983493 543 89644390
Atrial flutter 10.94 10.06 70 983444 10688 89634245
Vitamin B12 increased 10.92 10.06 44 983470 1782 89643151
Polyhydramnios 10.91 10.06 55 983459 2453 89642480
Congenital neuropathy 10.90 10.06 5 983509 15 89644918
Carotid artery occlusion 10.85 10.06 34 983480 6308 89638625
Congestive cardiomyopathy 10.85 10.06 42 983472 7312 89637621
Hiatus hernia 10.84 10.06 356 983158 25005 89619928
Euglycaemic diabetic ketoacidosis 10.78 10.06 33 983481 6168 89638765
Blood iron increased 10.76 10.06 46 983468 1913 89643020
Product adhesion issue 10.73 10.06 25 983489 5117 89639816
Activated partial thromboplastin time prolonged 10.72 10.06 46 983468 7779 89637154
Electric shock 10.70 10.06 42 983472 1680 89643253
Pulse absent 10.69 10.06 32 983482 6023 89638910
Clostridium test positive 10.69 10.06 27 983487 5374 89639559
Cardiac dysfunction 10.68 10.06 14 983500 3583 89641350
Product physical issue 10.66 10.06 29 983485 5631 89639302
Human antichimeric antibody positive 10.65 10.06 43 983471 1743 89643190
Cestode infection 10.64 10.06 15 983499 299 89644634
Cyst 10.64 10.06 245 983269 16316 89628617
Blood urea increased 10.61 10.06 250 983264 30163 89614770
Blood iron abnormal 10.61 10.06 17 983497 4003 89640930
Antibody test positive 10.60 10.06 62 983452 2927 89642006
Urine oxalate 10.60 10.06 3 983511 0 89644933
Homocystinaemia 10.60 10.06 3 983511 0 89644933
Cerumen removal 10.60 10.06 3 983511 0 89644933
Bladder transitional cell carcinoma stage I 10.60 10.06 3 983511 0 89644933
Urethral polyp 10.60 10.06 3 983511 0 89644933
Culture throat positive 10.60 10.06 3 983511 0 89644933
Post cholecystectomy syndrome 10.59 10.06 27 983487 854 89644079
Metastases to peritoneum 10.56 10.06 18 983496 4137 89640796
Secondary adrenocortical insufficiency 10.56 10.06 6 983508 2312 89642621
Incoherent 10.54 10.06 24 983490 4953 89639980
Papilloma excision 10.54 10.06 4 983510 6 89644927
Libido increased 10.40 10.06 3 983511 1741 89643192
Reversible cerebral vasoconstriction syndrome 10.40 10.06 18 983496 4112 89640821
Device loosening 10.36 10.06 27 983487 866 89644067
Escherichia bacteraemia 10.35 10.06 30 983484 5705 89639228
Aplastic anaemia 10.34 10.06 93 983421 13176 89631757
Immune-mediated hepatitis 10.33 10.06 10 983504 2934 89641999
Lung transplant 10.33 10.06 15 983499 3677 89641256
Mixed liver injury 10.33 10.06 45 983469 7578 89637355
Hypoxic-ischaemic encephalopathy 10.31 10.06 22 983492 4646 89640287
Wrist fracture 10.30 10.06 232 983282 15392 89629541
Red blood cell sedimentation rate 10.25 10.06 86 983428 4572 89640361
Drug eruption 10.25 10.06 299 983215 35108 89609825
Cogwheel rigidity 10.22 10.06 5 983509 2097 89642836
Lymphatic fistula 10.21 10.06 37 983477 1424 89643509
Device occlusion 10.17 10.06 59 983455 9223 89635710
Alcohol poisoning 10.17 10.06 4 983510 1908 89643025
Cataract operation 10.16 10.06 107 983407 6056 89638877
Hypovolaemic shock 10.15 10.06 41 983473 7053 89637880
Blood thyroid stimulating hormone increased 10.14 10.06 58 983456 9097 89635836
Hydronephrosis 10.07 10.06 86 983428 12316 89632617
Eye movement disorder 10.07 10.06 34 983480 6164 89638769
Gonorrhoea 10.07 10.06 10 983504 135 89644798
Areflexia 10.07 10.06 15 983499 3638 89641295
Infusion site pain 10.06 10.06 152 983362 19586 89625347

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 489.18 10.64 517 293874 228619 42098325
Rheumatoid arthritis 488.27 10.64 973 293418 41467 42285477
Drug abuse 354.27 10.64 140 294251 104631 42222313
Completed suicide 349.78 10.64 115 294276 96350 42230594
Drug interaction 343.77 10.64 842 293549 266157 42060787
Psoriatic arthropathy 214.55 10.64 509 293882 24458 42302486
Arthralgia 212.40 10.64 2259 292132 202979 42123965
Foetal exposure during pregnancy 209.41 10.64 761 293630 46550 42280394
Intentional overdose 180.13 10.64 65 294326 51391 42275553
Acute kidney injury 142.02 10.64 1740 292651 365597 41961347
Psoriasis 135.88 10.64 680 293711 47924 42279020
Joint swelling 128.19 10.64 857 293534 67165 42259779
Sickle cell anaemia with crisis 114.97 10.64 155 294236 4735 42322209
Coma 114.92 10.64 120 294271 53434 42273510
Dysmorphism 108.35 10.64 124 294267 3192 42323752
Serotonin syndrome 106.40 10.64 24 294367 25821 42301123
Rhabdomyolysis 105.72 10.64 239 294152 77780 42249164
Musculoskeletal stiffness 100.09 10.64 713 293678 57052 42269892
Febrile neutropenia 97.98 10.64 816 293575 184887 42142057
Pain 96.25 10.64 2291 292100 242557 42084387
Suicide attempt 91.58 10.64 110 294281 45990 42280954
Overdose 91.25 10.64 395 293996 104869 42222075
Arthritis 91.01 10.64 549 293842 41516 42285428
Disease progression 90.18 10.64 601 293790 143055 42183889
Nasopharyngitis 88.74 10.64 929 293462 83067 42243877
Drug resistance 86.35 10.64 66 294325 34182 42292762
Sedation 85.83 10.64 52 294339 30423 42296521
Drug ineffective 85.00 10.64 3527 290864 626670 41700274
Off label use 82.23 10.64 3591 290800 634744 41692200
Coombs positive haemolytic anaemia 79.63 10.64 67 294324 1168 42325776
Product use in unapproved indication 79.54 10.64 852 293539 183604 42143340
Blood pressure systolic increased 77.94 10.64 391 294000 27577 42299367
Blood pressure systolic abnormal 77.51 10.64 138 294253 5390 42321554
Drug reaction with eosinophilia and systemic symptoms 73.81 10.64 110 294281 41965 42284979
Blood pressure fluctuation 73.45 10.64 374 294017 26534 42300410
Death 73.07 10.64 2593 291798 468592 41858352
Cytomegalovirus infection 70.88 10.64 71 294320 32235 42294709
Enthesopathy 68.31 10.64 121 294270 4707 42322237
Weight decreased 67.69 10.64 1898 292493 206050 42120894
Poisoning 66.10 10.64 11 294380 14688 42312256
Angioedema 65.27 10.64 121 294270 42356 42284588
Fatigue 64.98 10.64 3652 290739 431989 41894955
Small for dates baby 64.52 10.64 124 294267 5139 42321805
Blood pressure diastolic abnormal 62.77 10.64 134 294257 5994 42320950
Exposure during pregnancy 62.61 10.64 164 294227 8384 42318560
Arthropathy 62.57 10.64 384 294007 29213 42297731
Synovitis 60.26 10.64 240 294151 15327 42311617
Hepatic function abnormal 59.76 10.64 171 294220 51396 42275548
Renal impairment 59.60 10.64 481 293910 109747 42217197
Juvenile idiopathic arthritis 59.54 10.64 82 294309 2557 42324387
Depressed level of consciousness 58.63 10.64 155 294236 47815 42279129
Cardiac failure 58.37 10.64 465 293926 106391 42220553
Haemoglobin decreased 58.01 10.64 1259 293132 131212 42195732
Tenosynovitis 56.80 10.64 110 294281 4585 42322359
Premature baby 56.48 10.64 312 294079 22841 42304103
Haemolysis 55.56 10.64 169 294222 9420 42317524
Osteoarthritis 55.01 10.64 322 294069 24083 42302861
Sopor 54.86 10.64 12 294379 13190 42313754
Lactic acidosis 54.75 10.64 147 294244 45114 42281830
Neuroleptic malignant syndrome 54.61 10.64 41 294350 21431 42305513
Speech disorder developmental 54.59 10.64 73 294318 2212 42324732
Altered state of consciousness 53.78 10.64 74 294317 29185 42297759
Pain in extremity 51.32 10.64 1383 293008 149221 42177723
Respiratory arrest 51.13 10.64 73 294318 28351 42298593
Grip strength decreased 50.86 10.64 90 294301 3498 42323446
Neonatal respiratory distress syndrome 50.10 10.64 102 294289 4411 42322533
Foetal anticonvulsant syndrome 49.89 10.64 51 294340 1151 42325793
Lymphadenitis 49.27 10.64 73 294318 2438 42324506
C-reactive protein abnormal 47.95 10.64 157 294234 9104 42317840
Cytokine release syndrome 47.77 10.64 153 294238 44374 42282570
Bradycardia 47.60 10.64 370 294021 85114 42241830
Infusion related reaction 47.57 10.64 635 293756 60171 42266773
Peripheral swelling 47.53 10.64 882 293509 89388 42237556
Suicidal ideation 44.65 10.64 176 294215 47985 42278959
Malignant neoplasm progression 44.56 10.64 506 293885 107894 42219050
Hypoglycaemia neonatal 44.35 10.64 64 294327 2086 42324858
Maternal exposure during pregnancy 44.26 10.64 127 294264 6851 42320093
Psychotic disorder 44.17 10.64 84 294307 29124 42297820
Myelosuppression 43.42 10.64 139 294252 40322 42286622
Neurotoxicity 43.28 10.64 60 294331 23591 42303353
Blood pressure diastolic increased 43.00 10.64 119 294272 6286 42320658
Acute hepatic failure 42.91 10.64 33 294358 17040 42309904
Heart rate decreased 42.86 10.64 413 293978 36119 42290825
Drug use disorder 41.73 10.64 10 294381 10323 42316621
Anaphylactic shock 41.71 10.64 61 294330 23456 42303488
Renal failure 41.59 10.64 720 293671 143006 42183938
Abdominal discomfort 41.26 10.64 740 293651 74515 42252429
Cytomegalovirus infection reactivation 41.06 10.64 13 294378 11165 42315779
Electrocardiogram QT prolonged 40.86 10.64 181 294210 47764 42279180
Immune reconstitution inflammatory syndrome 40.60 10.64 10 294381 10133 42316811
Aspergillus infection 40.59 10.64 30 294361 15807 42311137
Learning disorder 40.45 10.64 44 294347 1069 42325875
Low birth weight baby 39.76 10.64 155 294236 9800 42317144
Alanine aminotransferase abnormal 39.47 10.64 98 294293 4846 42322098
Substance abuse 39.30 10.64 7 294384 8898 42318046
Joint effusion 39.03 10.64 109 294282 5788 42321156
Drug ineffective for unapproved indication 38.90 10.64 175 294216 45988 42280956
Metabolic acidosis 38.83 10.64 205 294186 51653 42275291
Akathisia 38.66 10.64 12 294379 10439 42316505
Blood pressure increased 38.49 10.64 949 293442 100979 42225965
Therapy partial responder 38.46 10.64 49 294342 19972 42306972
Cryptorchism 38.44 10.64 58 294333 1969 42324975
Maternal drugs affecting foetus 38.23 10.64 83 294308 3756 42323188
Shock 37.99 10.64 91 294300 29030 42297914
Intentional self-injury 37.43 10.64 30 294361 15172 42311772
Toxic epidermal necrolysis 36.99 10.64 81 294310 26669 42300275
Foot deformity 36.88 10.64 97 294294 4971 42321973
Tachycardia 36.57 10.64 485 293906 100602 42226342
Hypospadias 36.53 10.64 78 294313 3489 42323455
Autism spectrum disorder 36.14 10.64 70 294321 2918 42324026
Venoocclusive liver disease 36.06 10.64 13 294378 10289 42316655
Crystal nephropathy 35.38 10.64 32 294359 617 42326327
Palmar-plantar erythrodysaesthesia syndrome 34.95 10.64 55 294336 20527 42306417
Rheumatoid nodule 34.81 10.64 69 294322 2926 42324018
Blood pressure diastolic decreased 34.72 10.64 153 294238 10222 42316722
Atrial septal defect 34.69 10.64 127 294264 7792 42319152
Post transplant lymphoproliferative disorder 34.59 10.64 10 294381 9110 42317834
BK virus infection 34.50 10.64 9 294382 8775 42318169
Knee arthroplasty 34.48 10.64 136 294255 8645 42318299
Cardiac arrest 33.79 10.64 541 293850 108779 42218165
Localised infection 33.27 10.64 248 294143 20125 42306819
Maternal exposure during breast feeding 33.12 10.64 47 294344 1508 42325436
Jaundice neonatal 32.63 10.64 56 294335 2123 42324821
Lower respiratory tract infection 32.50 10.64 431 293960 40775 42286169
Sinusitis 32.22 10.64 482 293909 46810 42280134
Syndactyly 32.19 10.64 36 294355 903 42326041
Therapeutic product effect decreased 31.93 10.64 412 293979 38738 42288206
Suspected suicide 31.85 10.64 3 294388 6196 42320748
Delirium 31.78 10.64 222 294169 52297 42274647
Aggression 31.73 10.64 177 294214 43986 42282958
Agitation 31.46 10.64 288 294103 64026 42262918
Colitis ulcerative 31.24 10.64 297 294094 25878 42301066
Wound 31.22 10.64 214 294177 16903 42310041
Acute graft versus host disease 31.17 10.64 9 294382 8206 42318738
Mucormycosis 30.70 10.64 6 294385 7137 42319807
Hepatic enzyme increased 30.17 10.64 464 293927 45320 42281624
Victim of child abuse 29.97 10.64 39 294352 1150 42325794
Astigmatism 29.49 10.64 41 294350 1290 42325654
Cardio-respiratory arrest 29.36 10.64 261 294130 58375 42268569
Joint laxity 29.32 10.64 24 294367 402 42326542
Haematochezia 29.04 10.64 566 293825 57870 42269074
Cardiotoxicity 28.54 10.64 8 294383 7437 42319507
Interstitial lung disease 28.54 10.64 376 294015 78086 42248858
Finger deformity 28.51 10.64 45 294346 1590 42325354
Inflammation 28.37 10.64 358 294033 33489 42293455
Posterior reversible encephalopathy syndrome 28.32 10.64 28 294363 12793 42314151
Hand deformity 28.32 10.64 73 294318 3695 42323249
Haematocrit decreased 28.32 10.64 367 294024 34541 42292403
Agranulocytosis 28.29 10.64 112 294279 30500 42296444
Drug level increased 28.12 10.64 90 294301 26110 42300834
Polyomavirus-associated nephropathy 28.11 10.64 3 294388 5612 42321332
Respiratory failure 28.06 10.64 672 293719 127460 42199484
Body temperature decreased 27.98 10.64 183 294208 14230 42312714
Ventricular septal defect 27.84 10.64 80 294311 4319 42322625
Hypokalaemia 27.83 10.64 339 294052 71382 42255562
Migraine with aura 27.75 10.64 33 294358 886 42326058
Pathogen resistance 27.69 10.64 23 294368 11427 42315517
Tongue disorder 27.64 10.64 91 294300 5292 42321652
Cytomegalovirus viraemia 27.45 10.64 19 294372 10358 42316586
Hypoglycaemia 26.75 10.64 274 294117 59580 42267364
Epidural lipomatosis 26.62 10.64 46 294345 1754 42325190
Hyperkalaemia 26.61 10.64 393 293998 80065 42246879
Exposure via breast milk 26.34 10.64 55 294336 2422 42324522
Appendicolith 26.21 10.64 171 294220 13285 42313659
Rash maculo-papular 26.03 10.64 152 294239 37351 42289593
Stress 25.74 10.64 439 293952 43773 42283171
Pulmonary alveolar haemorrhage 25.72 10.64 39 294352 14777 42312167
Basal cell carcinoma 25.68 10.64 255 294136 22478 42304466
No adverse event 25.59 10.64 161 294230 38860 42288084
Muscle swelling 25.53 10.64 23 294368 441 42326503
Haematotoxicity 25.43 10.64 23 294368 10962 42315982
Upper respiratory tract infection 25.38 10.64 421 293970 41752 42285192
Influenza 25.32 10.64 585 293806 61590 42265354
Mucocutaneous ulceration 25.06 10.64 24 294367 499 42326445
Wrong technique in product usage process 24.92 10.64 182 294209 42453 42284491
Bradycardia neonatal 24.76 10.64 38 294353 1310 42325634
Cellulitis 24.63 10.64 578 293813 61007 42265937
Thrombotic microangiopathy 24.62 10.64 40 294351 14742 42312202
Abdominal distension 24.47 10.64 659 293732 71076 42255868
Dysgraphia 24.43 10.64 54 294337 2474 42324470
Cystitis haemorrhagic 24.41 10.64 10 294381 7319 42319625
Hypermobility syndrome 24.04 10.64 20 294371 343 42326601
Plagiocephaly 24.00 10.64 25 294366 577 42326367
Acute chest syndrome 23.89 10.64 33 294358 1032 42325912
Caesarean section 23.85 10.64 48 294343 2058 42324886
Diffuse large B-cell lymphoma recurrent 23.49 10.64 3 294388 4883 42322061
Joint range of motion decreased 23.46 10.64 111 294280 7642 42319302
Acute graft versus host disease in skin 23.35 10.64 11 294380 7413 42319531
Developmental delay 23.25 10.64 61 294330 3121 42323823
Sleep disorder due to a general medical condition 23.19 10.64 54 294337 17399 42309545
Rebound effect 23.10 10.64 11 294380 7368 42319576
Hepatic failure 23.07 10.64 161 294230 37939 42289005
Red blood cell sedimentation rate increased 23.05 10.64 132 294259 9792 42317152
Red blood cell count decreased 22.89 10.64 335 294056 32380 42294564
Bronchopulmonary aspergillosis 22.82 10.64 64 294327 19365 42307579
Intervertebral disc degeneration 22.68 10.64 106 294285 7261 42319683
Pyrexia 22.61 10.64 2380 292011 391662 41935282
Tendonitis 22.59 10.64 131 294260 9763 42317181
Foetal growth restriction 22.53 10.64 84 294307 5199 42321745
Respiratory disorder neonatal 22.43 10.64 45 294346 1925 42325019
Asphyxia 22.35 10.64 15 294376 8311 42318633
Congenital hand malformation 22.29 10.64 25 294366 629 42326315
Hyperglycaemia 22.14 10.64 206 294185 45653 42281291
Multiple organ dysfunction syndrome 22.05 10.64 506 293885 96529 42230415
Proteinuria 21.93 10.64 83 294308 22900 42304044
Myoclonus 21.73 10.64 54 294337 17011 42309933
Polyarthritis 21.64 10.64 81 294310 5023 42321921
Multiple-drug resistance 21.31 10.64 12 294379 7310 42319634
Anal fissure 21.27 10.64 82 294309 5157 42321787
Vitamin D deficiency 21.19 10.64 111 294280 7962 42318982
Cardiac murmur 21.14 10.64 156 294235 12619 42314325
Large for dates baby 21.14 10.64 29 294362 901 42326043
Electrocardiogram QRS complex prolonged 20.98 10.64 7 294384 5816 42321128
Cholestasis 20.87 10.64 137 294254 32742 42294202
Talipes 20.75 10.64 47 294344 2189 42324755
Arthritis infective 20.71 10.64 69 294322 4037 42322907
Joint stiffness 20.69 10.64 151 294240 12171 42314773
Plantar fasciitis 20.57 10.64 57 294334 3013 42323931
Pneumonia 20.56 10.64 3267 291124 418882 41908062
Thrombocytopenia 20.42 10.64 1090 293301 189189 42137755
Status epilepticus 20.06 10.64 49 294342 15529 42311415
Adenovirus infection 20.05 10.64 11 294380 6798 42320146
Osteonecrosis of jaw 20.05 10.64 66 294325 18983 42307961
Ultrasound antenatal screen 19.98 10.64 22 294369 542 42326402
Contusion 19.96 10.64 404 293987 41581 42285363
Exposure to toxic agent 19.90 10.64 5 294386 4999 42321945
Hepatitis fulminant 19.63 10.64 5 294386 4954 42321990
Crohn's disease 19.60 10.64 55 294336 2929 42324015
Dyspraxia 19.50 10.64 20 294371 453 42326491
Back disorder 19.50 10.64 103 294288 7411 42319533
Loss of consciousness 19.49 10.64 487 293904 91867 42235077
Progressive multifocal leukoencephalopathy 19.42 10.64 31 294360 11505 42315439
Pancytopenia 19.41 10.64 997 293394 116746 42210198
Full blood count decreased 19.21 10.64 222 294169 20338 42306606
Agitation neonatal 19.19 10.64 35 294356 1393 42325551
Miosis 19.18 10.64 40 294351 13406 42313538
Dystonia 19.15 10.64 37 294354 12753 42314191
Drug withdrawal syndrome neonatal 19.08 10.64 71 294320 4390 42322554
Haemodynamic instability 19.08 10.64 36 294355 12521 42314423
Nephrolithiasis 19.07 10.64 359 294032 36471 42290473
Blood creatine phosphokinase increased 18.93 10.64 228 294163 48110 42278834
Headache 18.93 10.64 1909 292482 237460 42089484
Graft versus host disease in gastrointestinal tract 18.85 10.64 6 294385 5137 42321807
Cerebral haemorrhage 18.83 10.64 175 294216 38791 42288153
Chronic obstructive pulmonary disease 18.81 10.64 570 293821 62544 42264400
Blood test abnormal 18.80 10.64 153 294238 12753 42314191
Diaphragmatic disorder 18.76 10.64 32 294359 1207 42325737
Hydrops foetalis 18.76 10.64 27 294364 878 42326066
Stevens-Johnson syndrome 18.72 10.64 84 294307 22094 42304850
Musculoskeletal pain 18.67 10.64 329 294062 33011 42293933
Hypotension 18.63 10.64 1529 292862 256102 42070842
Hepatocellular injury 18.63 10.64 92 294299 23586 42303358
Drug withdrawal syndrome 18.57 10.64 81 294310 21468 42305476
Syringe issue 18.54 10.64 19 294372 8537 42318407
Ventricular tachycardia 18.48 10.64 127 294264 30033 42296911
Euglycaemic diabetic ketoacidosis 18.40 10.64 8 294383 5652 42321292
Post procedural infection 18.37 10.64 84 294307 5701 42321243
Potentiating drug interaction 18.26 10.64 11 294380 6457 42320487
Trisomy 18 18.21 10.64 26 294365 839 42326105
Hallucination, auditory 18.18 10.64 48 294343 14816 42312128
Asthenia 18.17 10.64 2210 292181 278583 42048361
Hallucination, visual 18.12 10.64 79 294312 20941 42306003
Migraine 18.08 10.64 261 294130 25153 42301791
Back pain 18.08 10.64 1173 293218 140603 42186341
Maternal exposure before pregnancy 17.90 10.64 29 294362 1048 42325896
Extrapyramidal disorder 17.87 10.64 56 294335 16356 42310588
Foetal disorder 17.86 10.64 29 294362 1050 42325894
Dyslexia 17.85 10.64 17 294374 351 42326593
Encephalitis toxic 17.80 10.64 15 294376 262 42326682
Arthrodesis 17.77 10.64 21 294370 560 42326384
Temperature regulation disorder 17.64 10.64 30 294361 1129 42325815
Language disorder 17.63 10.64 47 294344 2428 42324516
Oropharyngeal pain 17.62 10.64 401 293990 42109 42284835
Drug intolerance 17.62 10.64 701 293690 79723 42247221
Catarrh 17.61 10.64 85 294306 5901 42321043
Hyperammonaemia 17.58 10.64 17 294374 7849 42319095
Malignant melanoma 17.43 10.64 118 294273 9282 42317662
Nocardiosis 17.42 10.64 7 294384 5183 42321761
Selective eating disorder 17.41 10.64 38 294353 1726 42325218
Fall 17.36 10.64 1862 292529 232658 42094286
Frequent bowel movements 17.33 10.64 225 294166 21182 42305762
Disinhibition 17.32 10.64 3 294388 3892 42323052
Diverticulum 17.32 10.64 100 294291 7441 42319503
Neuralgia 17.31 10.64 261 294130 25386 42301558
Skin cancer 17.31 10.64 137 294254 11325 42315619
Nasal disorder 17.30 10.64 41 294350 1968 42324976
Cerebral infarction 17.29 10.64 135 294256 31034 42295910
Hepatic encephalopathy 17.28 10.64 57 294334 16385 42310559
Knee deformity 17.27 10.64 24 294367 755 42326189
Nephropathy toxic 17.27 10.64 59 294332 16779 42310165
Gingival pain 17.19 10.64 109 294282 8385 42318559
Heart rate irregular 17.15 10.64 178 294213 15872 42311072
Iron deficiency 17.14 10.64 133 294258 10928 42316016
Stiff person syndrome 17.07 10.64 13 294378 195 42326749
Ulcer 16.94 10.64 181 294210 16260 42310684
Synovial cyst 16.82 10.64 48 294343 2581 42324363
Hyperbilirubinaemia neonatal 16.78 10.64 25 294366 839 42326105
Accidental exposure to product 16.76 10.64 78 294313 20315 42306629
Serum ferritin increased 16.75 10.64 96 294295 7123 42319821
Skin abrasion 16.60 10.64 105 294286 8070 42318874
Tumour lysis syndrome 16.57 10.64 88 294303 22143 42304801
Endophthalmitis 16.56 10.64 5 294386 4428 42322516
Cough 16.56 10.64 1437 292954 176666 42150278
Transplant rejection 16.53 10.64 44 294347 13544 42313400
Abdominal pain 16.52 10.64 1529 292862 188942 42138002
Bronchitis 16.49 10.64 435 293956 46766 42280178
Appendicitis 16.42 10.64 216 294175 20397 42306547
Disseminated intravascular coagulation 16.41 10.64 102 294289 24692 42302252
Thymus disorder 16.41 10.64 14 294377 249 42326695
Intellectual disability 16.24 10.64 39 294352 1888 42325056
Eosinophilia 16.22 10.64 147 294244 32752 42294192
Scoliosis 16.19 10.64 53 294338 3073 42323871
Gait disturbance 16.18 10.64 830 293561 97170 42229774
Device leakage 16.06 10.64 29 294362 10256 42316688
Chronic graft versus host disease 15.98 10.64 11 294380 6014 42320930
Acute respiratory distress syndrome 15.97 10.64 132 294259 29976 42296968
Tuberculosis 15.96 10.64 122 294269 9977 42316967
Dysstasia 15.91 10.64 158 294233 13928 42313016
Motor developmental delay 15.90 10.64 22 294369 689 42326255
Flatulence 15.84 10.64 253 294138 24899 42302045
Ankylosing spondylitis 15.83 10.64 93 294298 6963 42319981
Radiation inflammation 15.78 10.64 27 294364 1021 42325923
Obsessive-compulsive disorder 15.75 10.64 14 294377 6729 42320215
Cataract 15.73 10.64 298 294093 30306 42296638
Ear infection 15.63 10.64 146 294245 12658 42314286
Ankyloglossia congenital 15.62 10.64 16 294375 362 42326582
Neutropenia 15.58 10.64 1176 293215 198255 42128689
Acute generalised exanthematous pustulosis 15.53 10.64 22 294369 8573 42318371
Blood phosphorus increased 15.38 10.64 143 294248 12382 42314562
Cleft lip and palate 15.36 10.64 25 294366 907 42326037
Congenital foot malformation 15.34 10.64 17 294374 422 42326522
Diabetic ketoacidosis 15.33 10.64 91 294300 22276 42304668
Leukopenia 15.27 10.64 396 293995 74350 42252594
Otitis media 15.24 10.64 58 294333 3625 42323319
Mass 15.20 10.64 108 294283 8631 42318313
Restlessness 15.17 10.64 129 294262 29120 42297824
Multiple congenital abnormalities 15.11 10.64 19 294372 541 42326403
Nephrotic syndrome 15.08 10.64 23 294368 8695 42318249
Colorectal cancer 15.04 10.64 8 294383 5030 42321914
Ear disorder 14.94 10.64 39 294352 1989 42324955
Systemic lupus erythematosus 14.94 10.64 113 294278 9211 42317733
Rotator cuff syndrome 14.91 10.64 87 294304 6499 42320445
Transient aphasia 14.88 10.64 20 294371 609 42326335
Spinal disorder 14.83 10.64 67 294324 4524 42322420
Haemophagocytic lymphohistiocytosis 14.80 10.64 70 294321 18152 42308792
Anaphylactic reaction 14.75 10.64 207 294184 42536 42284408
Dissociation 14.71 10.64 4 294387 3794 42323150
Fistula discharge 14.69 10.64 27 294364 1081 42325863
Hypotonia neonatal 14.68 10.64 32 294359 1452 42325492
Anal fistula 14.67 10.64 83 294308 6130 42320814
Steatorrhoea 14.50 10.64 23 294368 816 42326128
Immune effector cell-associated neurotoxicity syndrome 14.49 10.64 27 294364 9434 42317510
Disease recurrence 14.46 10.64 133 294258 29545 42297399
Urinary tract infection 14.43 10.64 831 293560 98453 42228491
Tenderness 14.43 10.64 108 294283 8775 42318169
Hypertransaminasaemia 14.42 10.64 26 294365 9201 42317743
Seizure 14.39 10.64 683 293708 119878 42207066
Cytopenia 14.34 10.64 67 294324 17430 42309514
Inguinal hernia 14.28 10.64 108 294283 8804 42318140
Central nervous system mass 14.26 10.64 23 294368 828 42326116
Lung hernia 14.22 10.64 8 294383 69 42326875
Hepatitis cholestatic 14.21 10.64 29 294362 9795 42317149
Wall motion score index abnormal 14.18 10.64 23 294368 832 42326112
Hallucination 14.17 10.64 296 294095 57211 42269733
Graft versus host disease 14.15 10.64 44 294347 12881 42314063
Burns second degree 14.10 10.64 81 294310 6015 42320929
Pneumonia aspiration 14.10 10.64 252 294139 49826 42277118
Spina bifida 14.10 10.64 16 294375 408 42326536
Shock haemorrhagic 14.02 10.64 61 294330 16181 42310763
Drug dose omission by device 14.01 10.64 12 294379 5874 42321070
Mean cell volume increased 14.01 10.64 59 294332 3864 42323080
Haemorrhage intracranial 13.99 10.64 66 294325 17126 42309818
Dry throat 13.96 10.64 48 294343 2854 42324090
Ischaemic stroke 13.93 10.64 93 294298 22140 42304804
C-reactive protein increased 13.92 10.64 554 293837 63006 42263938
Pleuritic pain 13.82 10.64 90 294301 6987 42319957
Bursitis 13.82 10.64 82 294309 6162 42320782
Cleft lip 13.76 10.64 14 294377 314 42326630
Intentional product misuse 13.71 10.64 324 294067 61576 42265368
Mobility decreased 13.70 10.64 330 294061 34976 42291968
Muscle twitching 13.69 10.64 39 294352 11741 42315203
Congenital bladder anomaly 13.63 10.64 13 294378 269 42326675
Limb reduction defect 13.62 10.64 14 294377 318 42326626
Medical device implantation 13.57 10.64 19 294372 602 42326342
Lacrimal disorder 13.55 10.64 14 294377 320 42326624
Hypocalcaemia 13.53 10.64 138 294253 30035 42296909
Cardiac septal defect 13.50 10.64 24 294367 936 42326008
Generalised tonic-clonic seizure 13.39 10.64 117 294274 26262 42300682
Bronchiolitis 13.37 10.64 58 294333 3848 42323096
Abdominal adhesions 13.35 10.64 34 294357 1708 42325236
Parosmia 13.35 10.64 95 294296 7596 42319348
Pectus excavatum 13.33 10.64 12 294379 230 42326714
Gastrointestinal infection 13.32 10.64 86 294305 6657 42320287
Weight decrease neonatal 13.31 10.64 14 294377 327 42326617
Airway remodelling 13.31 10.64 23 294368 877 42326067
Second primary malignancy 13.23 10.64 29 294362 9546 42317398
Transfusion-related circulatory overload 13.18 10.64 21 294370 748 42326196
Labelled drug-drug interaction medication error 13.16 10.64 59 294332 15523 42311421
Erythema multiforme 13.15 10.64 31 294360 9946 42316998
Unresponsive to stimuli 13.12 10.64 146 294245 31257 42295687
Sleep disorder therapy 13.06 10.64 87 294304 6807 42320137
Blister infected 12.92 10.64 17 294374 507 42326437
Renal aplasia 12.90 10.64 21 294370 762 42326182
Pleural fibrosis 12.88 10.64 29 294362 1345 42325599
Klebsiella infection 12.82 10.64 38 294353 11294 42315650
Septic arthritis staphylococcal 12.79 10.64 17 294374 512 42326432
Congenital anomaly 12.78 10.64 31 294360 1510 42325434
Pulmonary fibrosis 12.77 10.64 257 294134 26424 42300520
Analgesic therapy 12.76 10.64 83 294308 6441 42320503
Red blood cell sedimentation rate 12.69 10.64 25 294366 1055 42325889
Lipodystrophy acquired 12.69 10.64 4 294387 3446 42323498
Mydriasis 12.59 10.64 26 294365 8744 42318200
Strongyloidiasis 12.58 10.64 4 294387 3427 42323517
Cholelithiasis 12.58 10.64 229 294162 23117 42303827
Haemangioma congenital 12.54 10.64 17 294374 522 42326422
Blood parathyroid hormone decreased 12.52 10.64 32 294359 1611 42325333
Blood albumin decreased 12.52 10.64 162 294229 15240 42311704
Osteomyelitis 12.51 10.64 186 294205 18037 42308907
Exostosis 12.50 10.64 74 294317 5557 42321387
Ocular surface squamous neoplasia 12.47 10.64 6 294385 36 42326908
Septic shock 12.44 10.64 512 293879 91160 42235784
Bone cyst 12.42 10.64 32 294359 1619 42325325
Accidental death 12.42 10.64 3 294388 3080 42323864
Squamous cell carcinoma of lung 12.36 10.64 39 294352 2217 42324727
Hypoaesthesia 12.36 10.64 608 293783 70855 42256089
Umbilical hernia 12.36 10.64 72 294319 5375 42321569
Drug eruption 12.31 10.64 101 294290 22974 42303970
Hepatitis B 12.30 10.64 17 294374 6694 42320250
Blood cholesterol increased 12.28 10.64 256 294135 26485 42300459
Drug dependence 12.26 10.64 135 294256 28959 42297985
Spinal stenosis 12.23 10.64 81 294310 6325 42320619
Injection related reaction 12.22 10.64 18 294373 598 42326346
Enterocolitis 12.19 10.64 32 294359 9897 42317047
Hepatitis 12.18 10.64 125 294266 27175 42299769
Psychiatric decompensation 12.17 10.64 7 294384 4215 42322729
Hypertelorism 12.15 10.64 18 294373 601 42326343
Vein disorder 12.13 10.64 37 294354 2065 42324879
Paradoxical drug reaction 12.11 10.64 9 294382 4729 42322215
Joint ankylosis 12.10 10.64 32 294359 1645 42325299
Attention deficit hyperactivity disorder 12.09 10.64 48 294343 3060 42323884
Neck mass 12.05 10.64 34 294357 1816 42325128
Immunodeficiency 12.05 10.64 89 294302 7201 42319743
Atopy 11.99 10.64 23 294368 952 42325992
Kidney infection 11.97 10.64 84 294307 6686 42320258
Anaemia vitamin B12 deficiency 11.97 10.64 17 294374 546 42326398
Graft versus host disease in skin 11.96 10.64 11 294380 5201 42321743
Hip arthroplasty 11.96 10.64 70 294321 5235 42321709
Joint irrigation 11.95 10.64 3 294388 0 42326944
Adrenal insufficiency 11.94 10.64 79 294312 18845 42308099
Swelling 11.92 10.64 478 293913 54407 42272537
Muscle rigidity 11.87 10.64 43 294348 12016 42314928
Lung neoplasm malignant 11.83 10.64 192 294199 18955 42307989
Pharyngeal disorder 11.81 10.64 22 294369 890 42326054
Oesophageal fibrosis 11.81 10.64 10 294381 176 42326768
Hydrocele 11.80 10.64 42 294349 2541 42324403
Hepatic steatosis 11.78 10.64 211 294180 21237 42305707
Myringitis 11.71 10.64 6 294385 42 42326902
Nerve compression 11.71 10.64 57 294334 3971 42322973
Ligament rupture 11.70 10.64 28 294363 1352 42325592
Arthritis bacterial 11.69 10.64 75 294316 5793 42321151
Arthropod bite 11.59 10.64 49 294342 3215 42323729
Hyperlipidaemia 11.58 10.64 211 294180 21305 42305639
Tooth malformation 11.58 10.64 10 294381 181 42326763
Acute coronary syndrome 11.55 10.64 58 294333 14807 42312137
Fibula fracture 11.52 10.64 25 294366 1131 42325813
Hyperpyrexia 11.52 10.64 5 294386 3535 42323409
Hypermetropia 11.50 10.64 16 294375 504 42326440
Sedation complication 11.45 10.64 3 294388 2916 42324028
Oliguria 11.45 10.64 30 294361 9283 42317661
Weight increased 11.43 10.64 880 293511 107103 42219841
Face oedema 11.39 10.64 52 294339 13614 42313330
Energy increased 11.37 10.64 29 294362 1458 42325486
Abortion spontaneous 11.37 10.64 14 294377 390 42326554
Withdrawal syndrome 11.28 10.64 58 294333 14717 42312227
Neoplasm progression 11.27 10.64 137 294254 28863 42298081
Hernia pain 11.25 10.64 12 294379 285 42326659
Granuloma skin 11.24 10.64 25 294366 1150 42325794
Catatonia 11.24 10.64 16 294375 6223 42320721
Carcinoid tumour of the small bowel 11.23 10.64 14 294377 395 42326549
Hemiparaesthesia 11.22 10.64 10 294381 189 42326755
Unintentional medical device removal 11.22 10.64 4 294387 3187 42323757
Peritoneal dialysis complication 11.20 10.64 34 294357 1893 42325051
Neck pain 11.18 10.64 279 294112 29735 42297209
Subdural haematoma 11.14 10.64 104 294287 23034 42303910
Poor venous access 11.12 10.64 87 294304 7165 42319779
Spinal osteoarthritis 11.09 10.64 100 294291 8586 42318358
Pancreatitis acute 11.07 10.64 164 294227 33400 42293544
Abnormal behaviour 11.04 10.64 123 294268 26328 42300616
Affective disorder 11.02 10.64 15 294376 5945 42320999
Lower respiratory tract congestion 11.01 10.64 30 294361 1570 42325374
Encephalopathy 11.01 10.64 210 294181 41123 42285821
Hyperlactacidaemia 11.01 10.64 9 294382 4507 42322437
Cardiac failure chronic 11.00 10.64 32 294359 9569 42317375
Hyperthermia 10.99 10.64 47 294344 12527 42314417
Disability assessment scale score increased 10.99 10.64 14 294377 404 42326540
Oxygen saturation decreased 10.91 10.64 549 293842 64138 42262806
Apparent death 10.91 10.64 6 294385 3702 42323242
Brain oedema 10.89 10.64 67 294324 16260 42310684
Hepatitis E virus test positive 10.89 10.64 12 294379 296 42326648
Gallbladder disorder 10.87 10.64 87 294304 7215 42319729
Tinea pedis 10.85 10.64 35 294356 2013 42324931
Psychomotor hyperactivity 10.83 10.64 39 294352 10919 42316025
Anuria 10.78 10.64 42 294349 11490 42315454
Acute graft versus host disease in intestine 10.77 10.64 7 294384 3944 42323000
Labyrinthitis 10.73 10.64 22 294369 956 42325988
Hypopnoea 10.71 10.64 92 294299 7790 42319154
Epstein-Barr virus infection 10.70 10.64 33 294358 9685 42317259
Gross motor delay 10.67 10.64 13 294378 358 42326586

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1506.95 10.37 210 1007739 242171 109339179
Toxicity to various agents 1492.24 10.37 1311 1006638 479244 109102106
Drug interaction 974.22 10.37 1929 1006020 498254 109083096
Joint swelling 862.93 10.37 6942 1001007 435903 109145447
Drug abuse 834.69 10.37 287 1007662 177124 109404226
Arthropathy 805.55 10.37 4925 1003024 282597 109298753
Rheumatoid arthritis 772.23 10.37 5024 1002925 294589 109286761
Systemic lupus erythematosus 769.17 10.37 4445 1003504 249893 109331457
Pemphigus 715.90 10.37 3851 1004098 210719 109370631
Intentional overdose 710.80 10.37 167 1007782 132334 109449016
Synovitis 698.89 10.37 4584 1003365 269508 109311842
Hand deformity 696.98 10.37 3874 1004075 214632 109366718
Glossodynia 662.73 10.37 3867 1004082 218137 109363213
Pain 657.83 10.37 12282 995667 942673 108638677
Acute kidney injury 600.20 10.37 3369 1004580 632061 108949289
Infusion related reaction 590.42 10.37 5683 1002266 375479 109205871
Wound 574.68 10.37 3883 1004066 230554 109350796
Febrile neutropenia 553.51 10.37 1297 1006652 315470 109265880
Anti-cyclic citrullinated peptide antibody positive 552.84 10.37 3185 1004764 178799 109402551
Arthralgia 538.14 10.37 10033 997916 769599 108811751
Pericarditis 532.72 10.37 3622 1004327 215492 109365858
Abdominal discomfort 532.20 10.37 5710 1002239 388148 109193202
Death 493.43 10.37 4039 1003910 694830 108886520
Maternal exposure during pregnancy 484.52 10.37 3975 1003974 250908 109330442
Swelling 476.81 10.37 5095 1002854 345946 109235404
Alopecia 456.93 10.37 5210 1002739 359543 109221807
Duodenal ulcer perforation 448.41 10.37 2965 1004984 174735 109406615
Psoriatic arthropathy 439.83 10.37 3187 1004762 193574 109387776
Suicide attempt 435.74 10.37 198 1007751 103196 109478154
Hepatic enzyme increased 428.54 10.37 4642 1003307 316250 109265100
Helicobacter infection 422.80 10.37 2974 1004975 178903 109402447
Therapeutic product effect decreased 404.09 10.37 3695 1004254 240621 109340729
Contraindicated product administered 403.68 10.37 3741 1004208 244526 109336824
Nasopharyngitis 387.45 10.37 5384 1002565 388977 109192373
Cardiac arrest 360.28 10.37 785 1007164 195968 109385382
Discomfort 354.90 10.37 3247 1004702 211460 109369890
Sinusitis 348.37 10.37 4186 1003763 292502 109288848
Impaired healing 347.79 10.37 3019 1004930 193698 109387652
Musculoskeletal stiffness 335.54 10.37 3964 1003985 275858 109305492
Rhabdomyolysis 321.05 10.37 374 1007575 120027 109461323
Disease progression 320.18 10.37 1144 1006805 242890 109338460
Neutropenia 320.01 10.37 2049 1005900 372571 109208779
Rheumatoid factor positive 318.52 10.37 2174 1005775 129466 109451884
Lower respiratory tract infection 317.59 10.37 3502 1004447 239604 109341746
Lactic acidosis 310.10 10.37 235 1007714 92576 109488774
Folliculitis 307.91 10.37 2595 1005354 165058 109416292
Malignant neoplasm progression 307.75 10.37 711 1007238 173856 109407494
Cardiac failure 298.21 10.37 806 1007143 186820 109394530
Irritable bowel syndrome 292.21 10.37 2524 1005425 161691 109419659
Peripheral swelling 289.18 10.37 5232 1002717 398802 109182548
Drug reaction with eosinophilia and systemic symptoms 287.16 10.37 198 1007751 81897 109499453
Exposure during pregnancy 278.16 10.37 2535 1005414 164889 109416461
Fibromyalgia 274.98 10.37 2570 1005379 168339 109413011
Serotonin syndrome 274.15 10.37 98 1007851 59055 109522295
Coma 273.45 10.37 406 1007543 117463 109463887
Muscle injury 270.60 10.37 2202 1005747 138605 109442745
Renal impairment 263.04 10.37 860 1007089 187585 109393765
Blister 261.09 10.37 3195 1004754 224181 109357169
Electrocardiogram QT prolonged 248.24 10.37 380 1007569 108580 109472770
Bradycardia 247.92 10.37 667 1007282 154850 109426500
Osteoarthritis 244.08 10.37 2643 1005306 179980 109401370
Hypersensitivity 238.90 10.37 5083 1002866 398915 109182435
Renal failure 238.77 10.37 1156 1006793 225418 109355932
Drug resistance 235.89 10.37 109 1007840 56265 109525085
Rheumatic fever 234.48 10.37 1915 1006034 120664 109460686
Weight increased 234.17 10.37 5236 1002713 414408 109166942
Sleep disorder due to general medical condition, insomnia type 231.82 10.37 1704 1006245 103939 109477411
Bursitis 225.45 10.37 1986 1005963 127932 109453418
Angioedema 223.93 10.37 344 1007605 98156 109483194
Poisoning deliberate 223.87 10.37 3 1007946 26328 109555022
Sopor 223.84 10.37 33 1007916 36513 109544837
C-reactive protein abnormal 223.72 10.37 1980 1005969 127715 109453635
Myelosuppression 223.69 10.37 320 1007629 94020 109487330
Drug intolerance 222.69 10.37 5059 1002890 401453 109179897
Depressed level of consciousness 221.56 10.37 429 1007520 111849 109469501
Drug ineffective for unapproved indication 212.58 10.37 382 1007567 102456 109478894
Cardio-respiratory arrest 211.29 10.37 463 1007486 115373 109465977
Ill-defined disorder 203.12 10.37 2256 1005693 154597 109426753
Metabolic acidosis 202.17 10.37 375 1007574 99369 109481981
Cytomegalovirus infection 201.73 10.37 123 1007826 54321 109527029
Blood cholesterol increased 201.56 10.37 2572 1005377 182213 109399137
Respiratory arrest 200.73 10.37 143 1007806 58156 109523194
Hypotension 200.53 10.37 3462 1004487 520387 109060963
Overdose 198.35 10.37 1281 1006668 232513 109348837
Respiratory failure 197.71 10.37 1151 1006798 214181 109367169
Cytokine release syndrome 195.50 10.37 211 1007738 70095 109511255
Fatigue 191.85 10.37 13195 994754 1202763 108378587
Type 2 diabetes mellitus 189.56 10.37 2458 1005491 174774 109406576
Contusion 189.24 10.37 3084 1004865 230277 109351073
Altered state of consciousness 188.57 10.37 149 1007800 57477 109523873
Hepatic function abnormal 187.90 10.37 328 1007621 88967 109492383
Multiple organ dysfunction syndrome 184.73 10.37 733 1007216 150977 109430373
Hypoglycaemia 182.75 10.37 501 1007448 115603 109465747
Tachycardia 178.72 10.37 1269 1006680 225376 109355974
Stomatitis 178.46 10.37 3457 1004492 266785 109314565
Agitation 175.58 10.37 491 1007458 112560 109468790
Swollen joint count increased 174.24 10.37 1333 1006616 82328 109499022
Hyponatraemia 165.65 10.37 1231 1006718 216422 109364928
Poisoning 165.62 10.37 32 1007917 29073 109552277
Sickle cell anaemia with crisis 164.63 10.37 305 1007644 9240 109572110
Hyperkalaemia 163.50 10.37 659 1007290 135137 109446213
Inflammation 160.47 10.37 2564 1005385 190674 109390676
Intentional self-injury 160.31 10.37 70 1007879 37359 109543991
Somnolence 152.53 10.37 1855 1006094 295594 109285756
Mobility decreased 152.29 10.37 3024 1004925 234398 109346952
Arthritis 151.94 10.37 2257 1005692 165329 109416021
Grip strength decreased 151.93 10.37 1250 1006699 78924 109502426
Anaphylactic shock 150.90 10.37 148 1007801 51398 109529952
Knee arthroplasty 149.61 10.37 1060 1006889 63888 109517462
Joint range of motion decreased 149.00 10.37 1733 1006216 120099 109461251
Blood pressure systolic abnormal 146.28 10.37 529 1007420 24321 109557029
Hepatic failure 143.26 10.37 254 1007695 68485 109512865
Thrombocytopenia 142.80 10.37 2277 1005672 346608 109234742
Blood pressure fluctuation 142.54 10.37 1168 1006781 73656 109507694
Shock 141.18 10.37 168 1007781 53420 109527930
Red blood cell sedimentation rate abnormal 141.11 10.37 518 1007431 23991 109557359
Treatment failure 140.87 10.37 3415 1004534 273819 109307531
Immunodeficiency 140.31 10.37 713 1007236 38125 109543225
Night sweats 140.23 10.37 1851 1006098 132132 109449218
Off label use 139.22 10.37 11781 996168 1488404 108092946
Facet joint syndrome 139.01 10.37 1422 1006527 95406 109485944
Product use issue 138.07 10.37 3770 1004179 307925 109273425
Blood pressure diastolic abnormal 136.54 10.37 531 1007418 25284 109556066
Psoriasis 132.66 10.37 1900 1006049 138093 109443257
Pregnancy 129.85 10.37 854 1007095 50213 109531137
Cholestasis 129.47 10.37 244 1007705 64274 109517076
Hepatocellular injury 128.95 10.37 163 1007786 50479 109530871
Neurotoxicity 127.28 10.37 118 1007831 42089 109539261
Seizure 126.45 10.37 1346 1006603 219839 109361511
Drug use disorder 123.97 10.37 11 1007938 18063 109563287
Sedation 123.41 10.37 283 1007666 69400 109511950
Blood pressure systolic increased 123.08 10.37 1227 1006722 81764 109499586
Hip arthroplasty 122.83 10.37 901 1007048 54912 109526438
Pain in extremity 121.16 10.37 5514 1002435 481604 109099746
Hyperglycaemia 120.29 10.37 386 1007563 84704 109496646
Lip dry 119.87 10.37 1418 1006531 98665 109482685
Musculoskeletal pain 117.96 10.37 2333 1005616 180690 109400660
Ventricular tachycardia 117.19 10.37 171 1007778 49838 109531512
Acute hepatic failure 117.18 10.37 96 1007853 36372 109544978
Suspected suicide 116.93 10.37 5 1007944 15194 109566156
Leukopenia 116.81 10.37 834 1007115 147957 109433393
Neuroleptic malignant syndrome 116.65 10.37 84 1007865 33975 109547375
Injury 115.38 10.37 2263 1005686 175002 109406348
Interstitial lung disease 115.31 10.37 769 1007180 138565 109442785
Product use in unapproved indication 114.72 10.37 3151 1004798 444226 109137124
Sepsis 113.61 10.37 2200 1005749 325146 109256204
Suicidal ideation 112.98 10.37 456 1007493 93481 109487869
Infection 112.95 10.37 4200 1003749 358000 109223350
Coeliac disease 111.49 10.37 725 1007224 42462 109538888
Obesity 109.62 10.37 1544 1006405 111807 109469543
Disseminated intravascular coagulation 108.16 10.37 130 1007819 41156 109540194
Abortion spontaneous 107.92 10.37 606 1007343 33676 109547674
Thrombotic microangiopathy 107.78 10.37 66 1007883 29083 109552267
Encephalopathy 107.54 10.37 378 1007571 80677 109500673
Juvenile idiopathic arthritis 104.92 10.37 193 1007756 5814 109575536
Peripheral venous disease 104.84 10.37 1201 1006748 82916 109498434
Intentional product use issue 103.45 10.37 2976 1004973 244930 109336420
Therapy partial responder 103.28 10.37 111 1007838 36950 109544400
Live birth 102.88 10.37 1027 1006922 68457 109512893
Aspergillus infection 101.90 10.37 53 1007896 25563 109555787
Wound infection 101.47 10.37 1334 1006615 95131 109486219
Rash 101.45 10.37 8743 999206 812221 108769129
Red blood cell sedimentation rate increased 100.76 10.37 1125 1006824 77177 109504173
Hypokalaemia 99.59 10.37 1122 1006827 181326 109400024
Dry mouth 98.53 10.37 2453 1005496 197495 109383855
Syncope 98.20 10.37 1278 1006671 201258 109380092
Post transplant lymphoproliferative disorder 98.20 10.37 13 1007936 15600 109565750
Aggression 98.10 10.37 249 1007700 58961 109522389
Joint effusion 97.84 10.37 414 1007535 20491 109560859
Psychotic disorder 97.56 10.37 198 1007751 50739 109530611
Venoocclusive liver disease 97.25 10.37 12 1007937 15195 109566155
Torsade de pointes 97.21 10.37 42 1007907 22558 109558792
Bronchopulmonary aspergillosis 96.72 10.37 78 1007871 29785 109551565
Cerebral haemorrhage 96.60 10.37 288 1007661 64680 109516670
Cytomegalovirus infection reactivation 96.53 10.37 24 1007925 18309 109563041
Sciatica 96.45 10.37 1276 1006673 91123 109490227
Myoclonus 96.30 10.37 95 1007854 32903 109548447
Anaemia 95.69 10.37 4044 1003905 543042 109038308
Mydriasis 95.59 10.37 41 1007908 22116 109559234
Gastrointestinal disorder 95.10 10.37 2883 1005066 239069 109342281
Haematotoxicity 92.57 10.37 38 1007911 21044 109560306
Temperature regulation disorder 92.22 10.37 292 1007657 12534 109568816
Blood creatine phosphokinase increased 92.19 10.37 348 1007601 72729 109508621
Hypoxia 92.18 10.37 746 1007203 128769 109452581
Drug level increased 91.82 10.37 185 1007764 47534 109533816
Eosinophilia 91.16 10.37 250 1007699 57686 109523664
Hallucination 90.50 10.37 547 1007402 100885 109480465
Septic shock 89.86 10.37 959 1006990 156569 109424781
Palmar-plantar erythrodysaesthesia syndrome 89.70 10.37 147 1007802 40878 109540472
Akathisia 88.96 10.37 23 1007926 17090 109564260
C-reactive protein increased 88.71 10.37 2608 1005341 215311 109366039
Status epilepticus 88.60 10.37 94 1007855 31477 109549873
Posterior reversible encephalopathy syndrome 88.30 10.37 107 1007842 33754 109547596
Cerebral infarction 88.23 10.37 215 1007734 51623 109529727
Extrapyramidal disorder 87.88 10.37 80 1007869 28787 109552563
Disorientation 87.57 10.37 339 1007610 70332 109511018
Hypoaesthesia 86.52 10.37 3595 1004354 310628 109270722
No adverse event 85.95 10.37 363 1007586 73476 109507874
Ear pain 85.84 10.37 801 1007148 52425 109528925
Exposure to toxic agent 85.10 10.37 9 1007940 12849 109568501
Disability assessment scale score increased 83.33 10.37 144 1007805 4126 109577224
Loss of consciousness 83.01 10.37 1273 1006676 195033 109386317
Acute graft versus host disease 82.78 10.37 10 1007939 12871 109568479
Road traffic accident 82.45 10.37 1407 1006542 105991 109475359
Proteinuria 82.37 10.37 149 1007800 39869 109541481
Substance abuse 81.78 10.37 9 1007940 12454 109568896
Foot deformity 81.44 10.37 736 1007213 47744 109533606
Neoplasm progression 81.23 10.37 308 1007641 64287 109517063
Diabetic ketoacidosis 80.11 10.37 164 1007785 41894 109539456
Deep vein thrombosis postoperative 80.03 10.37 860 1007089 58431 109522919
Blood pressure diastolic decreased 79.93 10.37 581 1007368 35304 109546046
BK virus infection 79.88 10.37 12 1007937 13094 109568256
Tremor 79.65 10.37 1329 1006620 200903 109380447
Toxic epidermal necrolysis 79.02 10.37 259 1007690 56468 109524882
Dysarthria 78.58 10.37 447 1007502 83674 109497676
Immune reconstitution inflammatory syndrome 78.46 10.37 25 1007924 16201 109565149
Myocardial infarction 78.06 10.37 1255 1006694 190828 109390522
Drug dependence 77.83 10.37 217 1007732 49803 109531547
Neuropathy peripheral 77.71 10.37 1157 1006792 178120 109403230
Breast cancer stage III 77.01 10.37 1079 1006870 78038 109503312
Injection site reaction 76.60 10.37 1189 1006760 87881 109493469
Anaphylactic reaction 76.54 10.37 669 1007280 113631 109467719
Respiratory distress 76.27 10.37 345 1007604 68529 109512821
Prescribed overdose 76.04 10.37 1171 1006778 86410 109494940
Joint stiffness 75.41 10.37 941 1007008 66302 109515048
Acute respiratory distress syndrome 74.72 10.37 242 1007707 52956 109528394
Liver injury 74.29 10.37 1846 1006103 148567 109432783
Agranulocytosis 74.14 10.37 300 1007649 61460 109519890
Pancreatitis acute 72.85 10.37 292 1007657 59982 109521368
Heart rate decreased 72.81 10.37 1109 1006840 81647 109499703
Blood creatinine increased 72.64 10.37 1200 1006749 181689 109399661
Stevens-Johnson syndrome 72.58 10.37 204 1007745 46697 109534653
Transplant rejection 72.53 10.37 70 1007879 24497 109556853
Asphyxia 72.20 10.37 20 1007929 14195 109567155
Hypothermia 71.94 10.37 80 1007869 26222 109555128
Upper respiratory tract infection 71.94 10.37 1635 1006314 129693 109451657
Haemophagocytic lymphohistiocytosis 71.92 10.37 110 1007839 31449 109549901
Rash maculo-papular 71.73 10.37 390 1007559 73832 109507518
Wrong technique in product usage process 71.30 10.37 484 1007465 86864 109494486
Neutrophil count decreased 70.71 10.37 732 1007217 120209 109461141
Food allergy 69.82 10.37 363 1007586 19585 109561765
Pathogen resistance 69.65 10.37 37 1007912 17635 109563715
Autoimmune disorder 69.05 10.37 906 1007043 64577 109516773
Disturbance in attention 68.97 10.37 310 1007639 61685 109519665
Mucormycosis 68.92 10.37 8 1007941 10620 109570730
Enthesopathy 68.72 10.37 260 1007689 12218 109569132
Carpal tunnel syndrome 68.10 10.37 395 1007554 22215 109559135
Cytomegalovirus viraemia 67.40 10.37 39 1007910 17725 109563625
Acute generalised exanthematous pustulosis 67.19 10.37 59 1007890 21605 109559745
Unresponsive to stimuli 66.83 10.37 326 1007623 63464 109517886
Dehydration 66.43 10.37 1989 1005960 277522 109303828
Accidental exposure to product 65.80 10.37 234 1007715 49774 109531576
Dystonia 65.76 10.37 83 1007866 25722 109555628
Ischaemic stroke 64.96 10.37 178 1007771 41085 109540265
Tumour lysis syndrome 64.91 10.37 113 1007836 30688 109550662
Lower limb fracture 63.72 10.37 1003 1006946 74345 109507005
Blood pressure diastolic increased 63.60 10.37 339 1007610 18468 109562882
Miosis 63.33 10.37 64 1007885 21919 109559431
Adverse event 63.18 10.37 1366 1006583 107443 109473907
Restlessness 62.78 10.37 281 1007668 55978 109525372
Abnormal behaviour 62.51 10.37 167 1007782 38872 109542478
Face oedema 62.49 10.37 132 1007817 33337 109548013
Unintentional medical device removal 62.39 10.37 5 1007944 8918 109572432
Polyomavirus-associated nephropathy 62.10 10.37 3 1007946 8198 109573152
Osteoporosis 61.98 10.37 1128 1006821 86024 109495326
Gait inability 61.87 10.37 1655 1006294 134721 109446629
Toxic skin eruption 61.66 10.37 97 1007852 27418 109553932
Drug withdrawal syndrome 61.53 10.37 162 1007787 37892 109543458
Hallucination, visual 61.49 10.37 172 1007777 39433 109541917
Cardiotoxicity 61.34 10.37 39 1007910 16842 109564508
Psychomotor hyperactivity 60.77 10.37 57 1007892 20220 109561130
Acute graft versus host disease in skin 60.71 10.37 12 1007937 10728 109570622
Melaena 60.70 10.37 372 1007577 68385 109512965
Bone erosion 60.46 10.37 668 1007281 45703 109535647
Ejection fraction decreased 60.21 10.37 182 1007767 40698 109540652
Gamma-glutamyltransferase increased 59.88 10.37 321 1007628 60988 109520362
Paradoxical drug reaction 59.81 10.37 9 1007940 9808 109571542
Ear infection 59.24 10.37 851 1007098 61881 109519469
Osteonecrosis of jaw 59.06 10.37 231 1007718 47786 109533564
Tachypnoea 59.03 10.37 174 1007775 39221 109542129
Inappropriate antidiuretic hormone secretion 58.71 10.37 139 1007810 33712 109547638
Polycystic ovaries 58.71 10.37 133 1007816 4663 109576687
Haemorrhage intracranial 58.61 10.37 109 1007840 28860 109552490
Metastases to liver 58.47 10.37 149 1007800 35237 109546113
Muscle rigidity 58.46 10.37 80 1007869 23951 109557399
Pulmonary alveolar haemorrhage 57.67 10.37 59 1007890 20091 109561259
Sensitisation 57.51 10.37 121 1007828 4030 109577320
Pulmonary oedema 57.31 10.37 613 1007336 100046 109481304
Atrial fibrillation 57.10 10.37 1624 1006325 228018 109353332
Generalised tonic-clonic seizure 56.96 10.37 280 1007669 54400 109526950
Cytopenia 56.88 10.37 118 1007831 29998 109551352
Clostridium difficile colitis 56.84 10.37 206 1007743 43572 109537778
Arrhythmia 56.54 10.37 386 1007563 69189 109512161
Second primary malignancy 56.29 10.37 49 1007900 18019 109563331
Hypomagnesaemia 56.27 10.37 321 1007628 60049 109521301
Graft versus host disease 56.20 10.37 53 1007896 18753 109562597
Schizophrenia 55.83 10.37 70 1007879 21756 109559594
Hyperthermia 55.70 10.37 67 1007882 21205 109560145
Disease recurrence 55.69 10.37 325 1007624 60459 109520891
Exostosis 54.96 10.37 651 1007298 45305 109536045
Haemodynamic instability 54.88 10.37 77 1007872 22811 109558539
Aphasia 54.83 10.37 314 1007635 58683 109522667
Epstein-Barr virus infection 54.62 10.37 54 1007895 18684 109562666
Localised infection 54.25 10.37 616 1007333 42432 109538918
Rebound effect 54.08 10.37 34 1007915 14772 109566578
Coombs positive haemolytic anaemia 53.62 10.37 69 1007880 1508 109579842
Polyneuropathy 53.51 10.37 134 1007815 31878 109549472
Hypercholesterolaemia 53.26 10.37 1142 1006807 89695 109491655
Adenovirus infection 53.05 10.37 17 1007932 10977 109570373
Ejection fraction 52.95 10.37 96 1007853 2859 109578491
Withdrawal syndrome 52.73 10.37 131 1007818 31249 109550101
Dislocation of vertebra 52.58 10.37 620 1007329 43101 109538249
Loss of personal independence in daily activities 52.49 10.37 1763 1006186 148257 109433093
Polyarthritis 52.45 10.37 324 1007625 18639 109562711
Urinary retention 52.08 10.37 396 1007553 69287 109512063
Femur fracture 51.89 10.37 627 1007322 43842 109537508
Labelled drug-drug interaction medication error 51.88 10.37 119 1007830 29183 109552167
Hyperbilirubinaemia 51.57 10.37 128 1007821 30543 109550807
Myalgia 51.46 10.37 1588 1006361 220793 109360557
Joint destruction 51.43 10.37 217 1007732 10726 109570624
Hemiplegia 51.35 10.37 80 1007869 22702 109558648
Acute myeloid leukaemia 51.03 10.37 177 1007772 37933 109543417
Parkinsonism 50.88 10.37 77 1007872 22110 109559240
Blood bilirubin increased 50.71 10.37 445 1007504 75527 109505823
Cardiac failure congestive 50.47 10.37 1021 1006928 149979 109431371
Multiple-drug resistance 50.30 10.37 29 1007920 13206 109568144
Electrocardiogram QRS complex prolonged 50.24 10.37 28 1007921 12993 109568357
Onychomycosis 50.20 10.37 555 1007394 37976 109543374
Mucosal inflammation 50.20 10.37 597 1007352 95544 109485806
Coagulopathy 50.20 10.37 197 1007752 40714 109540636
Pulmonary fibrosis 49.68 10.37 1250 1006699 100792 109480558
Body temperature decreased 49.50 10.37 535 1007414 36400 109544950
Dyskinesia 49.34 10.37 271 1007678 51175 109530175
Sleep disorder 48.71 10.37 2246 1005703 196398 109384952
Abdominal pain upper 48.59 10.37 3753 1004196 345358 109235992
Laryngitis 48.20 10.37 595 1007354 41816 109539534
Foetal death 48.12 10.37 280 1007669 15765 109565585
Anuria 48.01 10.37 93 1007856 24248 109557102
Shock haemorrhagic 47.96 10.37 111 1007838 27136 109554214
Bronchospasm 47.93 10.37 130 1007819 30109 109551241
Febrile bone marrow aplasia 47.90 10.37 53 1007896 17412 109563938
Dyspnoea 47.80 10.37 9127 998822 1097745 108483605
Onychomadesis 47.40 10.37 630 1007319 45033 109536317
Joint laxity 46.91 10.37 83 1007866 2424 109578926
Drug dose omission by device 46.90 10.37 38 1007911 14478 109566872
Haemoptysis 46.29 10.37 421 1007528 70933 109510417
Dysphagia 46.28 10.37 1056 1006893 152544 109428806
Chronic kidney disease 46.14 10.37 458 1007491 75833 109505517
Weight decreased 46.11 10.37 4907 1003042 463150 109118200
Respiratory depression 46.04 10.37 144 1007805 31857 109549493
Mania 45.95 10.37 74 1007875 20722 109560628
Asthma-chronic obstructive pulmonary disease overlap syndrome 45.95 10.37 3 1007946 6341 109575009
Intentional product misuse 45.81 10.37 894 1007055 132010 109449340
Adjustment disorder with depressed mood 45.78 10.37 606 1007343 43277 109538073
Bradyphrenia 45.57 10.37 25 1007924 11703 109569647
Diffuse large B-cell lymphoma recurrent 45.56 10.37 3 1007946 6296 109575054
Pyrexia 45.56 10.37 7342 1000607 890923 108690427
Stress cardiomyopathy 45.55 10.37 46 1007903 15760 109565590
Device difficult to use 45.35 10.37 63 1007886 18742 109562608
Nocardiosis 45.29 10.37 7 1007942 7479 109573871
Rheumatoid nodule 44.85 10.37 328 1007621 19968 109561382
Graft versus host disease in gastrointestinal tract 44.84 10.37 13 1007936 8955 109572395
Erythema multiforme 44.82 10.37 77 1007872 21020 109560330
Retinitis 44.60 10.37 471 1007478 31856 109549494
Oliguria 44.50 10.37 63 1007886 18594 109562756
Nail disorder 44.45 10.37 759 1007190 57176 109524174
Metastases to bone 43.86 10.37 143 1007806 31229 109550121
Hepatotoxicity 43.82 10.37 368 1007581 63032 109518318
Blepharospasm 43.70 10.37 723 1007226 54128 109527222
Pemphigoid 43.66 10.37 70 1007879 19637 109561713
Muscle twitching 43.57 10.37 134 1007815 29801 109551549
Myocarditis 42.71 10.37 136 1007813 29919 109551431
Immune effector cell-associated neurotoxicity syndrome 42.62 10.37 43 1007906 14739 109566611
Device expulsion 42.36 10.37 142 1007807 30749 109550601
Obstructive airways disorder 42.15 10.37 247 1007702 45902 109535448
Crystal nephropathy 42.14 10.37 67 1007882 1789 109579561
Irritability 42.02 10.37 259 1007690 47550 109533800
Cystitis haemorrhagic 41.96 10.37 30 1007919 12179 109569171
Brain oedema 41.93 10.37 144 1007805 30954 109550396
Hyperammonaemia 41.87 10.37 38 1007911 13694 109567656
Klebsiella infection 41.63 10.37 74 1007875 19935 109561415
Chronic graft versus host disease 41.60 10.37 17 1007932 9440 109571910
Nausea 41.47 10.37 10315 997634 1225375 108355975
Hemiparesis 41.16 10.37 233 1007716 43670 109537680
Hepatitis B reactivation 40.99 10.37 9 1007940 7475 109573875
C-reactive protein 40.95 10.37 440 1007509 29891 109551459
Subdural haematoma 40.72 10.37 182 1007767 36272 109545078
Hepatitis cholestatic 40.25 10.37 61 1007888 17505 109563845
Condition aggravated 40.20 10.37 7442 1000507 727394 108853956
Acute coronary syndrome 40.01 10.37 95 1007854 23017 109558333
Nephropathy toxic 39.99 10.37 123 1007826 27355 109553995
Hallucination, auditory 39.98 10.37 116 1007833 26281 109555069
Circulatory collapse 39.86 10.37 229 1007720 42764 109538586
Lip swelling 39.75 10.37 284 1007665 50383 109530967
Dyspepsia 39.52 10.37 2124 1005825 188841 109392509
Caesarean section 39.43 10.37 238 1007711 13579 109567771
Colorectal cancer 39.10 10.37 17 1007932 9097 109572253
Gestational diabetes 39.08 10.37 152 1007797 7237 109574113
Maternal exposure timing unspecified 38.93 10.37 326 1007623 20687 109560663
Tenosynovitis 38.81 10.37 268 1007681 16015 109565335
Tenderness 38.81 10.37 425 1007524 29012 109552338
Gastrointestinal haemorrhage 38.52 10.37 1181 1006768 164337 109417013
Mental status changes 38.48 10.37 476 1007473 75646 109505704
Haematoma 38.38 10.37 344 1007605 58132 109523218
Cytomegalovirus chorioretinitis 38.18 10.37 9 1007940 7119 109574231
Vasoplegia syndrome 38.16 10.37 3 1007946 5436 109575914
Sinus tachycardia 38.09 10.37 243 1007706 44250 109537100
Hyperhidrosis 38.02 10.37 1360 1006589 185938 109395412
Pulmonary arterial hypertension 37.96 10.37 160 1007789 32408 109548942
Motor dysfunction 37.88 10.37 106 1007843 24300 109557050
Subarachnoid haemorrhage 37.75 10.37 141 1007808 29561 109551789
Colitis ulcerative 37.75 10.37 948 1007001 76415 109504935
Graft versus host disease in skin 37.69 10.37 14 1007935 8240 109573110
Personality disorder 37.41 10.37 37 1007912 12800 109568550
Device use error 37.37 10.37 18 1007931 9071 109572279
Migraine 37.29 10.37 1918 1006031 169734 109411616
Jaundice cholestatic 37.21 10.37 47 1007902 14561 109566789
Skin exfoliation 37.17 10.37 568 1007381 87083 109494267
Blood lactic acid increased 37.16 10.37 54 1007895 15767 109565583
Ascites 37.15 10.37 608 1007341 92200 109489150
Bronchitis 37.10 10.37 1769 1006180 155263 109426087
Ileus 37.05 10.37 149 1007800 30580 109550770
Intervertebral disc degeneration 37.00 10.37 287 1007662 17798 109563552
Potentiating drug interaction 36.97 10.37 31 1007918 11612 109569738
Acute myocardial infarction 36.87 10.37 539 1007410 83238 109498112
Hepatitis fulminant 36.67 10.37 16 1007933 8544 109572806
Blood glucose increased 36.58 10.37 923 1007026 131573 109449777
Spinal stenosis 36.57 10.37 298 1007651 18758 109562592
Hypomania 36.54 10.37 24 1007925 10186 109571164
Hepatic cytolysis 36.51 10.37 323 1007626 54730 109526620
Multiple fractures 36.51 10.37 170 1007779 8770 109572580
Tendonitis 35.97 10.37 380 1007569 25703 109555647
Metastases to lung 35.92 10.37 100 1007849 22963 109558387
Diabetes insipidus 35.78 10.37 8 1007941 6562 109574788
Respiratory acidosis 35.72 10.37 44 1007905 13782 109567568
Jaundice 35.66 10.37 356 1007593 58880 109522470
Angina pectoris 35.61 10.37 379 1007570 61916 109519434
Cardiac failure acute 35.60 10.37 107 1007842 23971 109557379
Sinus bradycardia 35.52 10.37 143 1007806 29340 109552010
Myopathy 35.43 10.37 113 1007836 24847 109556503
Dissociation 35.40 10.37 23 1007926 9819 109571531
Pleural effusion 35.25 10.37 1294 1006655 176415 109404935
Headache 35.18 10.37 8803 999146 873574 108707776
Hypogammaglobulinaemia 35.17 10.37 82 1007867 19994 109561356
Enterocolitis 35.15 10.37 75 1007874 18874 109562476
Generalised oedema 35.08 10.37 152 1007797 30552 109550798
Injection site erythema 35.06 10.37 1115 1006834 93061 109488289
Finger deformity 34.94 10.37 458 1007491 32634 109548716
Gastrooesophageal reflux disease 34.93 10.37 1990 1005959 177986 109403364
Acute chest syndrome 34.77 10.37 66 1007883 2037 109579313
Hyperlactacidaemia 34.69 10.37 16 1007933 8270 109573080
Device leakage 34.62 10.37 58 1007891 15990 109565360
Hypocalcaemia 34.47 10.37 405 1007544 64961 109516389
X-ray abnormal 34.38 10.37 513 1007436 37604 109543746
Hepatic cirrhosis 34.28 10.37 833 1007116 66793 109514557
Hepatitis acute 34.21 10.37 75 1007874 18691 109562659
Sleep terror 34.14 10.37 9 1007940 6601 109574749
Drug ineffective 34.13 10.37 12904 995045 1507636 108073714
Maternal exposure before pregnancy 34.09 10.37 144 1007805 7121 109574229
Platelet count decreased 34.05 10.37 1734 1006215 228709 109352641
Lung disorder 33.64 10.37 1984 1005965 178063 109403287
Cardiac failure chronic 33.57 10.37 46 1007903 13765 109567585
Bacteraemia 33.55 10.37 237 1007712 42153 109539197
Pruritus genital 33.46 10.37 9 1007940 6513 109574837
Neck deformity 33.45 10.37 61 1007888 1825 109579525
Transaminases increased 33.33 10.37 393 1007556 62997 109518353
Lupus vulgaris 33.33 10.37 463 1007486 33420 109547930
Bladder cancer 33.10 10.37 86 1007863 20206 109561144
Wheezing 33.09 10.37 2729 1005220 252501 109328849
Leukocytosis 33.03 10.37 322 1007627 53506 109527844
Muscle spasticity 33.03 10.37 485 1007464 35430 109545920
Tongue disorder 32.71 10.37 233 1007716 14065 109567285
Speech disorder 32.65 10.37 381 1007568 61188 109520162
Endophthalmitis 32.48 10.37 17 1007932 8170 109573180
General physical health deterioration 32.26 10.37 4386 1003563 420909 109160441
Blood pressure decreased 32.24 10.37 800 1007149 114291 109467059
Tardive dyskinesia 32.24 10.37 46 1007903 13533 109567817
Basal cell carcinoma 32.21 10.37 586 1007363 44684 109536666
Skin toxicity 32.05 10.37 36 1007913 11747 109569603
Delusion 32.03 10.37 110 1007839 23645 109557705
Transplant dysfunction 32.00 10.37 18 1007931 8310 109573040
Frequent bowel movements 31.98 10.37 865 1007084 70525 109510825
Wheelchair user 31.93 10.37 149 1007800 7693 109573657
Neurologic neglect syndrome 31.75 10.37 23 1007926 9275 109572075
Device related infection 31.74 10.37 220 1007729 39299 109542051
Strongyloidiasis 31.72 10.37 4 1007945 4982 109576368
Joint dislocation 31.56 10.37 462 1007487 33728 109547622
Lupus-like syndrome 31.51 10.37 535 1007414 40257 109541093
Virologic failure 31.44 10.37 4 1007945 4948 109576402
Synovial cyst 31.43 10.37 195 1007754 11235 109570115
Bradypnoea 31.40 10.37 20 1007929 8629 109572721
Gastroenteritis viral 31.25 10.37 428 1007521 30798 109550552
Exposure via ingestion 31.01 10.37 4 1007945 4896 109576454
Hypertransaminasaemia 30.92 10.37 115 1007834 24140 109557210
Immune-mediated myositis 30.87 10.37 9 1007940 6177 109575173
Smear cervix abnormal 30.77 10.37 73 1007876 2639 109578711
Palpitations 30.75 10.37 1163 1006786 158049 109423301
Joint noise 30.71 10.37 110 1007839 5033 109576317
Diabetes mellitus inadequate control 30.71 10.37 153 1007796 29622 109551728
Accidental overdose 30.59 10.37 313 1007636 51521 109529829
Foot operation 30.56 10.37 140 1007809 7173 109574177
Chest discomfort 30.54 10.37 1284 1006665 172564 109408786
Human herpesvirus 6 infection 30.33 10.37 11 1007938 6570 109574780
Hyperpyrexia 30.21 10.37 18 1007931 8051 109573299
Carotid artery thrombosis 30.19 10.37 26 1007923 9612 109571738
Toxic encephalopathy 30.12 10.37 58 1007891 15156 109566194
Haemorrhage 30.05 10.37 741 1007208 105951 109475399
Red blood cell sedimentation rate 29.85 10.37 110 1007839 5104 109576246
Pneumonia aspiration 29.67 10.37 541 1007408 80692 109500658
Acute lymphocytic leukaemia recurrent 29.66 10.37 8 1007941 5779 109575571
Accidental death 29.60 10.37 5 1007944 5004 109576346
Immunosuppressant drug level increased 29.57 10.37 38 1007911 11686 109569664
Anti-cyclic citrullinated peptide antibody 29.51 10.37 295 1007654 19669 109561681
Product administration error 29.49 10.37 208 1007741 37009 109544341
Ketoacidosis 29.48 10.37 29 1007920 10058 109571292
Pseudomonas infection 29.37 10.37 142 1007807 27711 109553639
Nodule 29.36 10.37 439 1007510 32192 109549158
Hepatocellular carcinoma 29.34 10.37 28 1007921 9852 109571498
Acute pulmonary oedema 29.31 10.37 70 1007879 16926 109564424
Blood pressure increased 29.22 10.37 2735 1005214 255638 109325712
Cardiogenic shock 29.19 10.37 358 1007591 56980 109524370
Bone marrow failure 29.14 10.37 362 1007587 57486 109523864
Back injury 29.11 10.37 600 1007349 46799 109534551
Hyperuricaemia 29.11 10.37 55 1007894 14476 109566874
Forced expiratory volume decreased 29.00 10.37 47 1007902 13129 109568221
Injection site pruritus 28.95 10.37 641 1007308 50617 109530733
Acute respiratory failure 28.83 10.37 497 1007452 74763 109506587
Affective disorder 28.80 10.37 36 1007913 11205 109570145
Capillary leak syndrome 28.78 10.37 5 1007944 4903 109576447
Hypernatraemia 28.77 10.37 76 1007873 17757 109563593
Tubulointerstitial nephritis 28.75 10.37 336 1007613 53948 109527402
Venoocclusive disease 28.61 10.37 11 1007938 6339 109575011
Acute myeloid leukaemia recurrent 28.51 10.37 6 1007943 5133 109576217
Palmoplantar keratoderma 28.46 10.37 7 1007942 5380 109575970
Atrioventricular block complete 28.45 10.37 91 1007858 19991 109561359
Oesophageal carcinoma 28.40 10.37 38 1007911 11486 109569864
Right ventricular failure 28.14 10.37 131 1007818 25823 109555527
Pulmonary congestion 28.14 10.37 166 1007783 30800 109550550
Sexual dysfunction 27.97 10.37 22 1007927 8508 109572842
Blood test abnormal 27.61 10.37 389 1007560 28165 109553185
Haematemesis 27.52 10.37 376 1007573 58732 109522618
Arthritis infective 27.48 10.37 176 1007773 10253 109571097
Pulseless electrical activity 27.35 10.37 71 1007878 16686 109564664
Ventricular arrhythmia 27.24 10.37 31 1007918 10056 109571294
Ulcer 27.21 10.37 548 1007401 42568 109538782
Gastric haemorrhage 27.09 10.37 66 1007883 15849 109565501
Renal injury 27.07 10.37 84 1007865 18629 109562721
Vision blurred 27.06 10.37 933 1007016 128089 109453261
Insomnia 27.00 10.37 3716 1004233 356874 109224476
Glomerular filtration rate decreased 26.97 10.37 154 1007795 28802 109552548
Lymphopenia 26.94 10.37 235 1007714 39935 109541415
Polyuria 26.82 10.37 78 1007871 17660 109563690
Anti-neutrophil cytoplasmic antibody positive vasculitis 26.81 10.37 8 1007941 5409 109575941
Immune-mediated enterocolitis 26.75 10.37 32 1007917 10153 109571197
Pneumatosis intestinalis 26.73 10.37 23 1007926 8506 109572844
Cyanosis 26.72 10.37 160 1007789 29581 109551769
Acute graft versus host disease in intestine 26.72 10.37 9 1007940 5630 109575720
Acidosis 26.69 10.37 110 1007839 22421 109558929
Premature rupture of membranes 26.69 10.37 98 1007851 4539 109576811
Sudden death 26.53 10.37 123 1007826 24272 109557078
Latent tuberculosis 26.30 10.37 88 1007861 3889 109577461
Vomiting 26.29 10.37 7651 1000298 903024 108678326
Bradykinesia 26.16 10.37 36 1007913 10752 109570598
Euglycaemic diabetic ketoacidosis 26.02 10.37 41 1007908 11582 109569768
Foot fracture 25.91 10.37 351 1007598 25195 109556155
Disturbance in social behaviour 25.91 10.37 7 1007942 5051 109576299
Pulmonary embolism 25.83 10.37 1646 1006303 212828 109368522
Product label confusion 25.70 10.37 318 1007631 22359 109558991
Prescribed underdose 25.68 10.37 777 1007172 64397 109516953
Breast cancer stage I 25.58 10.37 18 1007931 7369 109573981
Hyperprolactinaemia 25.57 10.37 14 1007935 6561 109574789
Alanine aminotransferase abnormal 25.51 10.37 159 1007790 9175 109572175
Spinal osteoarthritis 25.51 10.37 289 1007660 19894 109561456
Cognitive disorder 25.41 10.37 605 1007344 86906 109494444
Hypertension 25.27 10.37 5141 1002808 504943 109076407
Fear 25.19 10.37 117 1007832 23076 109558274
Atrial tachycardia 25.01 10.37 28 1007921 9150 109572200
Oropharyngeal pain 24.95 10.37 1489 1006460 133787 109447563
Red blood cell count decreased 24.93 10.37 782 1007167 65141 109516209
Premature labour 24.92 10.37 156 1007793 9016 109572334
Limb deformity 24.87 10.37 83 1007866 3663 109577687
Metastases to central nervous system 24.84 10.37 115 1007834 22702 109558648
Intracranial pressure increased 24.70 10.37 36 1007913 10499 109570851
Hypertensive crisis 24.70 10.37 126 1007823 24246 109557104
Disability 24.68 10.37 400 1007549 29823 109551527
Dermatitis acneiform 24.61 10.37 49 1007900 12646 109568704
Presyncope 24.60 10.37 306 1007643 48581 109532769
Neck mass 24.55 10.37 98 1007851 4723 109576627
Neck pain 24.38 10.37 1364 1006585 121766 109459584
Cerebrovascular accident 24.36 10.37 1377 1006572 179907 109401443
Nervous system disorder 24.30 10.37 179 1007770 31542 109549808
Swollen tongue 24.30 10.37 395 1007554 59967 109521383
Paranoia 24.22 10.37 113 1007836 22261 109559089
Varicella zoster virus infection 24.13 10.37 14 1007935 6354 109574996
Ileus paralytic 23.89 10.37 44 1007905 11693 109569657
Blood lactate dehydrogenase increased 23.64 10.37 274 1007675 44060 109537290
Fracture delayed union 23.64 10.37 58 1007891 2143 109579207
Pneumocystis jirovecii pneumonia 23.62 10.37 262 1007687 42473 109538877
Haemolysis 23.56 10.37 232 1007717 15407 109565943
Bone disorder 23.52 10.37 296 1007653 20896 109560454
Joint injury 23.50 10.37 503 1007446 39491 109541859
Systemic candida 23.47 10.37 34 1007915 9940 109571410
Kidney transplant rejection 23.46 10.37 46 1007903 11941 109569409
Liver function test increased 23.41 10.37 1009 1006940 87539 109493811
Hepatitis B 23.38 10.37 32 1007917 9580 109571770
Hepatic encephalopathy 23.34 10.37 156 1007793 28100 109553250
Paralysis 23.30 10.37 69 1007880 15531 109565819
Taste disorder 23.26 10.37 770 1007179 64617 109516733
Pneumonia bacterial 23.22 10.37 142 1007807 26119 109555231
Nightmare 23.21 10.37 234 1007715 38629 109542721
Bacterial sepsis 23.13 10.37 37 1007912 10389 109570961
Cross sensitivity reaction 22.92 10.37 11 1007938 5556 109575794
Oedema 22.89 10.37 2217 1005732 207759 109373591
Lymphadenitis 22.83 10.37 105 1007844 5388 109575962
Hyperthermia malignant 22.81 10.37 4 1007945 3896 109577454
Vascular stent thrombosis 22.79 10.37 5 1007944 4156 109577194
Nephrectomy 22.67 10.37 64 1007885 2576 109578774
Peripheral sensory neuropathy 22.65 10.37 77 1007872 16603 109564747
Congestive cardiomyopathy 22.63 10.37 61 1007888 14158 109567192
Linear IgA disease 22.62 10.37 6 1007943 4383 109576967
Rotator cuff repair 22.54 10.37 58 1007891 2208 109579142
Psychotic symptom 22.54 10.37 4 1007945 3863 109577487
Cardiomyopathy 22.54 10.37 196 1007753 33329 109548021
Herpes zoster 22.52 10.37 1206 1006743 107173 109474177
Fracture 22.50 10.37 334 1007615 24454 109556896
Product monitoring error 22.45 10.37 29 1007920 8898 109572452
Dermatitis bullous 22.41 10.37 83 1007866 17446 109563904
Renal cancer 22.22 10.37 54 1007895 12980 109568370
Cytomegalovirus colitis 22.18 10.37 19 1007930 7042 109574308
Haematuria 22.17 10.37 581 1007368 82424 109498926
Exposure via skin contact 22.00 10.37 55 1007894 13092 109568258
Hypoxic-ischaemic encephalopathy 21.98 10.37 29 1007920 8818 109572532
Hypotonia 21.85 10.37 72 1007877 15673 109565677
Bone density decreased 21.79 10.37 233 1007716 15809 109565541
Back pain 21.71 10.37 3771 1004178 367225 109214125
Hypercapnia 21.69 10.37 43 1007906 11116 109570234
Pneumothorax 21.68 10.37 211 1007738 35074 109546276
Neutrophilia 21.67 10.37 38 1007911 10291 109571059
Pulmonary haemorrhage 21.65 10.37 77 1007872 16379 109564971
Swelling face 21.65 10.37 658 1007291 91663 109489687
Drug effective for unapproved indication 21.64 10.37 62 1007887 14105 109567245
Ataxia 21.61 10.37 173 1007776 29935 109551415
Polyomavirus viraemia 21.59 10.37 3 1007946 3471 109577879
Type I hypersensitivity 21.59 10.37 16 1007933 6377 109574973
Pre-eclampsia 21.59 10.37 144 1007805 8506 109572844
Drug tolerance decreased 21.56 10.37 362 1007587 27178 109554172
Diplopia 21.54 10.37 261 1007688 41633 109539717
Hyperthyroidism 21.53 10.37 167 1007782 29094 109552256
Atrioventricular block 21.52 10.37 80 1007869 16797 109564553
Nasal polyps 21.49 10.37 56 1007893 13144 109568206
Affect lability 21.45 10.37 92 1007857 18545 109562805
Product administered to patient of inappropriate age 21.37 10.37 25 1007924 8011 109573339
Scleritis 21.35 10.37 102 1007847 5318 109576032
Malignant mediastinal neoplasm 21.26 10.37 42 1007907 1336 109580014
Total lung capacity increased 21.21 10.37 10 1007939 5102 109576248
Cholangitis 21.12 10.37 77 1007872 16258 109565092
Treatment noncompliance 21.08 10.37 505 1007444 72485 109508865
Dactylitis 21.04 10.37 84 1007865 4049 109577301
Pallor 20.95 10.37 375 1007574 56092 109525258
Lupus vasculitis 20.95 10.37 27 1007922 591 109580759
Wrong patient received product 20.91 10.37 18 1007931 6656 109574694
Cryptococcosis 20.90 10.37 8 1007941 4623 109576727
Osteopenia 20.85 10.37 301 1007648 21908 109559442
Steroid diabetes 20.71 10.37 11 1007938 5243 109576107
Urticaria 20.66 10.37 3259 1004690 315598 109265752
Wrong product administered 20.65 10.37 43 1007906 10917 109570433
Metastasis 20.64 10.37 27 1007922 8240 109573110
Adjustment disorder 20.64 10.37 42 1007907 10753 109570597
Mental disorder 20.59 10.37 240 1007709 38551 109542799
Amylase increased 20.46 10.37 53 1007896 12466 109568884
Blindness 20.46 10.37 222 1007727 36137 109545213
Synovial disorder 20.30 10.37 67 1007882 2940 109578410
Infection reactivation 20.25 10.37 6 1007943 4075 109577275
Epstein-Barr viraemia 20.23 10.37 4 1007945 3575 109577775
Immune thrombocytopenia 20.22 10.37 121 1007828 22373 109558977
Osteonecrosis 20.22 10.37 203 1007746 33538 109547812
Antinuclear antibody positive 20.17 10.37 148 1007801 9020 109572330
Pulmonary hypertension 20.09 10.37 368 1007581 54852 109526498
Salivary hypersecretion 20.05 10.37 86 1007863 17335 109564015
Personality change 20.03 10.37 44 1007905 10958 109570392
Victim of child abuse 20.02 10.37 38 1007911 1173 109580177
Metabolic disorder 20 10.37 41 1007908 10469 109570881
Post procedural infection 19.90 10.37 203 1007746 13606 109567744
Impaired work ability 19.86 10.37 345 1007604 26074 109555276
Ejection fraction abnormal 19.81 10.37 73 1007876 3387 109577963
Hypoglycaemic coma 19.81 10.37 13 1007936 5520 109575830
Kounis syndrome 19.79 10.37 15 1007934 5910 109575440
Laryngeal oedema 19.75 10.37 37 1007912 9770 109571580
Electrolyte imbalance 19.69 10.37 229 1007720 36799 109544551
Spinal disorder 19.67 10.37 178 1007771 11550 109569800
Throat clearing 19.65 10.37 85 1007864 4248 109577102
Ankylosing spondylitis 19.49 10.37 223 1007726 15389 109565961
Systemic inflammatory response syndrome 19.26 10.37 58 1007891 12985 109568365
Gastric cancer 19.25 10.37 45 1007904 10963 109570387
Ankle arthroplasty 19.19 10.37 59 1007890 2492 109578858
Aplastic anaemia 19.19 10.37 136 1007813 24172 109557178
Body temperature increased 19.13 10.37 643 1007306 54070 109527280
Catatonia 19.12 10.37 47 1007902 11253 109570097
Skin ulcer 19.07 10.37 735 1007214 62910 109518440
International normalised ratio increased 19.01 10.37 624 1007325 86148 109495202
Cerebral toxoplasmosis 18.87 10.37 3 1007946 3139 109578211
Cleft lip and palate 18.83 10.37 28 1007921 704 109580646
Genital haemorrhage 18.82 10.37 23 1007926 7229 109574121
Psychiatric decompensation 18.74 10.37 15 1007934 5750 109575600
Candida infection 18.72 10.37 316 1007633 47693 109533657
Visual acuity reduced 18.69 10.37 195 1007754 31978 109549372
Arteriospasm coronary 18.62 10.37 34 1007915 9066 109572284
Cyst 18.56 10.37 231 1007718 16265 109565085
Haematocrit decreased 18.52 10.37 758 1007191 65359 109515991
Neutropenic colitis 18.48 10.37 28 1007921 8037 109573313
Diarrhoea 18.39 10.37 9777 998172 1129728 108451622
Rotator cuff syndrome 18.39 10.37 234 1007715 16560 109564790
Myocardial ischaemia 18.39 10.37 155 1007794 26529 109554821
Anticholinergic syndrome 18.34 10.37 8 1007941 4272 109577078
Vasculitis 18.25 10.37 224 1007725 35649 109545701
Leukoencephalopathy 18.25 10.37 35 1007914 9160 109572190
Infection susceptibility increased 18.23 10.37 84 1007865 4314 109577036
Orthostatic hypotension 18.15 10.37 462 1007487 65787 109515563
Retinal haemorrhage 18.13 10.37 37 1007912 9464 109571886
Oxalosis 18.12 10.37 13 1007936 131 109581219
Loose body in joint 18.08 10.37 40 1007909 1380 109579970
Enterococcal infection 18.07 10.37 110 1007839 20256 109561094
Areflexia 18.07 10.37 21 1007928 6748 109574602
Injection site bruising 18.06 10.37 603 1007346 50660 109530690
Pneumonitis 18.06 10.37 545 1007404 75986 109505364
Behaviour disorder 18.05 10.37 38 1007911 9609 109571741
Sensory loss 17.95 10.37 118 1007831 21339 109560011
Colitis 17.91 10.37 756 1007193 101567 109479783
Vascular purpura 17.90 10.37 6 1007943 3765 109577585
Complications of transplanted kidney 17.88 10.37 25 1007924 7417 109573933
Endodontic procedure 17.82 10.37 66 1007883 3070 109578280
Deafness transitory 17.70 10.37 34 1007915 1059 109580291
Cardiac tamponade 17.63 10.37 49 1007900 11258 109570092
Mucocutaneous ulceration 17.63 10.37 28 1007921 747 109580603
Epstein-Barr virus associated lymphoproliferative disorder 17.58 10.37 11 1007938 4791 109576559
Muscle spasms 17.56 10.37 2839 1005110 275318 109306032
Type 1 diabetes mellitus 17.47 10.37 35 1007914 9012 109572338
Hydrops foetalis 17.47 10.37 28 1007921 753 109580597
Heparin-induced thrombocytopenia 17.45 10.37 50 1007899 11374 109569976
Synovial fluid analysis 17.45 10.37 59 1007890 2622 109578728
Bone density increased 17.42 10.37 32 1007917 963 109580387
Escherichia bacteraemia 17.42 10.37 42 1007907 10122 109571228
Epistaxis 17.38 10.37 991 1006958 129381 109451969
Tenosynovitis stenosans 17.36 10.37 72 1007877 3531 109577819
Cogwheel rigidity 17.35 10.37 6 1007943 3692 109577658
Low turnover osteopathy 17.35 10.37 49 1007900 1973 109579377
Skin papilloma 17.33 10.37 115 1007834 6781 109574569
Pericardial effusion 17.33 10.37 393 1007556 56824 109524526
Glycosylated haemoglobin increased 17.28 10.37 135 1007814 23484 109557866
Gait disturbance 17.28 10.37 2837 1005112 275371 109305979
Blood alkaline phosphatase increased 17.27 10.37 503 1007446 70432 109510918
Hyperreflexia 17.22 10.37 38 1007911 9447 109571903
Accidental exposure to product by child 17.20 10.37 4 1007945 3194 109578156
Renal tubular necrosis 17.18 10.37 186 1007763 30289 109551061
Hepatitis C 17.10 10.37 58 1007891 12515 109568835
Immunisation 17.09 10.37 4 1007945 3179 109578171
Flushing 17.06 10.37 780 1007169 103956 109477394
Lipase increased 17.02 10.37 100 1007849 18572 109562778
Corneal oedema 17.01 10.37 4 1007945 3169 109578181
Psychomotor retardation 16.96 10.37 28 1007921 7764 109573586
Body tinea 16.93 10.37 50 1007899 2065 109579285
Epstein-Barr virus infection reactivation 16.92 10.37 8 1007941 4076 109577274
Concomitant disease aggravated 16.92 10.37 84 1007865 16280 109565070
Rales 16.91 10.37 144 1007805 24595 109556755
Acute lung injury 16.84 10.37 4 1007945 3147 109578203
Lip oedema 16.83 10.37 27 1007922 7573 109573777
Renal tubular disorder 16.83 10.37 26 1007923 7403 109573947
Seronegative arthritis 16.80 10.37 189 1007760 12988 109568362
Parvovirus B19 infection 16.75 10.37 3 1007946 2878 109578472
Ultrasound antenatal screen 16.74 10.37 26 1007923 680 109580670
Tuberculosis 16.73 10.37 241 1007708 17533 109563817
Nephrotic syndrome 16.71 10.37 67 1007882 13764 109567586
Skin cancer 16.69 10.37 241 1007708 17543 109563807
Laryngospasm 16.67 10.37 11 1007938 4657 109576693
Prerenal failure 16.62 10.37 10 1007939 4449 109576901
Emotional distress 16.59 10.37 298 1007651 44549 109536801
Mouth ulceration 16.39 10.37 564 1007385 47574 109533776
Pneumonia fungal 16.28 10.37 74 1007875 14680 109566670
Incorrect dose administered 16.25 10.37 775 1007174 102866 109478484
Rheumatoid lung 16.24 10.37 80 1007869 4224 109577126
Abortion incomplete 16.22 10.37 4 1007945 3068 109578282
Anxiety 16.18 10.37 2832 1005117 342246 109239104
Delirium 16.13 10.37 1037 1006912 133988 109447362
Facial paralysis 16.08 10.37 142 1007807 24072 109557278
Brain abscess 16.03 10.37 23 1007926 6751 109574599
Nystagmus 16.02 10.37 53 1007896 11524 109569826
Fanconi syndrome 16.02 10.37 6 1007943 3513 109577837
Anosmia 15.98 10.37 59 1007890 12413 109568937
Eyelid oedema 15.98 10.37 78 1007871 15184 109566166
Left ventricular dysfunction 15.95 10.37 137 1007812 23356 109557994
Plantar fasciitis 15.94 10.37 90 1007859 5011 109576339
Vitamin B12 increased 15.90 10.37 48 1007901 2007 109579343
Necrotising fasciitis 15.86 10.37 28 1007921 7563 109573787
Brain injury 15.83 10.37 66 1007883 13410 109567940
Oral herpes 15.83 10.37 436 1007513 35644 109545706
Syringe issue 15.82 10.37 40 1007909 9485 109571865
Pulmonary vasculitis 15.80 10.37 22 1007927 6538 109574812
Clonus 15.75 10.37 35 1007914 8681 109572669
Liver transplant rejection 15.74 10.37 8 1007941 3910 109577440
Product prescribing error 15.71 10.37 352 1007597 50979 109530371
Amyloid arthropathy 15.69 10.37 42 1007907 1638 109579712
Immune-mediated hepatitis 15.67 10.37 23 1007926 6688 109574662
Hallucinations, mixed 15.64 10.37 35 1007914 8658 109572692
Wound infection pseudomonas 15.64 10.37 53 1007896 2358 109578992
Sputum discoloured 15.57 10.37 171 1007778 27774 109553576
Inadequate analgesia 15.54 10.37 14 1007935 5063 109576287
Nail operation 15.47 10.37 42 1007907 1652 109579698
Sickle cell anaemia 15.47 10.37 27 1007922 780 109580570
Blood parathyroid hormone decreased 15.47 10.37 185 1007764 12904 109568446
Normal newborn 15.42 10.37 283 1007666 21613 109559737
Hydrocephalus 15.42 10.37 46 1007903 10329 109571021
Granuloma skin 15.38 10.37 164 1007785 11119 109570231
Respiratory disorder 15.37 10.37 797 1007152 70585 109510765
Candida sepsis 15.35 10.37 4 1007945 2957 109578393
Neoplasm recurrence 15.34 10.37 15 1007934 5217 109576133
Vertebral osteophyte 15.34 10.37 22 1007927 535 109580815
Walking aid user 15.26 10.37 317 1007632 24758 109556592
Mood altered 15.26 10.37 123 1007826 21252 109560098
Persecutory delusion 15.25 10.37 21 1007928 6270 109575080
Delayed graft function 15.24 10.37 10 1007939 4247 109577103
Rash morbilliform 15.15 10.37 31 1007918 7920 109573430
Oculogyric crisis 15.14 10.37 8 1007941 3824 109577526
Tooth disorder 15.11 10.37 364 1007585 29145 109552205
Secondary adrenocortical insufficiency 15.10 10.37 11 1007938 4423 109576927
Hypoalbuminaemia 15.09 10.37 180 1007769 28794 109552556
Neurological symptom 15.08 10.37 82 1007867 15526 109565824
Compartment syndrome 15.07 10.37 19 1007930 5891 109575459
Depressive symptom 15.03 10.37 34 1007915 8380 109572970
Conjunctivitis allergic 15.00 10.37 25 1007924 6906 109574444
Postoperative wound infection 14.99 10.37 214 1007735 15539 109565811
Heart rate irregular 14.99 10.37 414 1007535 33860 109547490
Musculoskeletal disorder 14.96 10.37 290 1007659 22374 109558976
Breast feeding 14.95 10.37 25 1007924 697 109580653
Pancreatitis 14.94 10.37 698 1007251 92835 109488515
Drug screen positive 14.94 10.37 22 1007927 6388 109574962
Product preparation error 14.92 10.37 50 1007899 10829 109570521
Poor venous access 14.92 10.37 310 1007639 24212 109557138
Trisomy 18 14.91 10.37 23 1007926 598 109580752
Drug tolerance 14.87 10.37 223 1007726 16362 109564988
Depressed mood 14.85 10.37 431 1007518 60378 109520972
Disinhibition 14.85 10.37 5 1007944 3129 109578221
Staphylococcal infection 14.85 10.37 505 1007444 69439 109511911
Methaemoglobinaemia 14.84 10.37 39 1007910 9129 109572221
Cerebral haematoma 14.83 10.37 42 1007907 9590 109571760
Diabetes mellitus 14.82 10.37 747 1007202 98634 109482716
Lethargy 14.81 10.37 699 1007250 92877 109488473
Drug eruption 14.75 10.37 374 1007575 53285 109528065
Eosinophilic granulomatosis with polyangiitis 14.74 10.37 49 1007900 10637 109570713
Human antichimeric antibody positive 14.74 10.37 42 1007907 1700 109579650
Granulocyte count decreased 14.69 10.37 9 1007940 3965 109577385
Pulmonary pain 14.66 10.37 103 1007846 6190 109575160
Bradyarrhythmia 14.63 10.37 14 1007935 4920 109576430
Ingrown hair 14.63 10.37 26 1007923 762 109580588
Spondylitis 14.63 10.37 163 1007786 11175 109570175
Hypocoagulable state 14.62 10.37 3 1007946 2612 109578738
Dust allergy 14.58 10.37 20 1007929 5981 109575369
Eye movement disorder 14.55 10.37 43 1007906 9685 109571665
Enterobacter infection 14.49 10.37 19 1007930 5792 109575558
Coronary artery disease 14.44 10.37 521 1007428 71169 109510181
Electric shock 14.43 10.37 43 1007906 1785 109579565
Disorganised speech 14.43 10.37 6 1007943 3297 109578053
Post cholecystectomy syndrome 14.41 10.37 27 1007922 825 109580525
Cell death 14.37 10.37 19 1007930 5772 109575578
Malignant melanoma 14.33 10.37 225 1007724 16666 109564684
Dry skin 14.22 10.37 819 1007130 106834 109474516
Blood folate increased 14.15 10.37 22 1007927 576 109580774
Haemorrhagic transformation stroke 14.12 10.37 5 1007944 3032 109578318
Staphylococcal sepsis 14.10 10.37 97 1007852 17357 109563993
Cardiopulmonary failure 14.07 10.37 32 1007917 7871 109573479
Intestinal ischaemia 14.04 10.37 88 1007861 16091 109565259
Mitochondrial toxicity 14.01 10.37 6 1007943 3239 109578111
Meniscus injury 13.96 10.37 120 1007829 7673 109573677
Aplasia 13.92 10.37 32 1007917 7841 109573509
Epidural lipomatosis 13.90 10.37 46 1007903 2021 109579329
Dyspnoea at rest 13.90 10.37 35 1007914 8311 109573039
Psychomotor skills impaired 13.89 10.37 27 1007922 7031 109574319
Bone pain 13.89 10.37 470 1007479 64663 109516687
Staphylococcal bacteraemia 13.85 10.37 92 1007857 16596 109564754
Stillbirth 13.84 10.37 76 1007873 4188 109577162
Ligament rupture 13.83 10.37 73 1007876 3962 109577388
Plasma cell myeloma recurrent 13.80 10.37 27 1007922 7015 109574335
Cellulitis 13.80 10.37 1331 1006618 124685 109456665
Progressive multifocal leukoencephalopathy 13.79 10.37 153 1007796 24803 109556547
Priapism 13.77 10.37 20 1007929 5841 109575509
Acquired gene mutation 13.76 10.37 4 1007945 2750 109578600
Dysphonia 13.71 10.37 559 1007390 75370 109505980
Rhinovirus infection 13.69 10.37 58 1007891 11731 109569619
Body height below normal 13.68 10.37 46 1007903 2038 109579312
Chronic sinusitis 13.64 10.37 312 1007637 24772 109556578
Rheumatoid factor increased 13.63 10.37 52 1007897 2453 109578897
Gangrene 13.61 10.37 90 1007859 16251 109565099
Lymphatic fistula 13.59 10.37 37 1007912 1458 109579892
Viral haemorrhagic cystitis 13.57 10.37 7 1007942 3392 109577958
Cataract 13.56 10.37 869 1007080 78616 109502734
Tetany 13.55 10.37 8 1007941 3596 109577754
Apnoea 13.55 10.37 71 1007878 13568 109567782
Nodal osteoarthritis 13.52 10.37 27 1007922 866 109580484
Transplant failure 13.47 10.37 19 1007930 5616 109575734
Hypertriglyceridaemia 13.43 10.37 89 1007860 16065 109565285
Hypertonia 13.43 10.37 36 1007913 8370 109572980
Arterial occlusive disease 13.42 10.37 83 1007866 15225 109566125
Lichenoid keratosis 13.39 10.37 23 1007926 6279 109575071
Hiatus hernia 13.38 10.37 338 1007611 27268 109554082
Femoral hernia incarcerated 13.37 10.37 37 1007912 1472 109579878
COVID-19 pneumonia 13.36 10.37 248 1007701 36895 109544455
Hypovolaemic shock 13.34 10.37 78 1007871 14505 109566845
Asthma 13.34 10.37 2532 1005417 247759 109333591
Mycotic allergy 13.33 10.37 21 1007928 5933 109575417
Ulcer haemorrhage 13.30 10.37 284 1007665 22287 109559063
Lower respiratory tract congestion 13.30 10.37 82 1007867 4714 109576636
Maternal exposure during delivery 13.28 10.37 8 1007941 3557 109577793
Nephrogenic diabetes insipidus 13.27 10.37 3 1007946 2442 109578908
Liver abscess 13.24 10.37 32 1007917 7707 109573643
Incoherent 13.20 10.37 36 1007913 8322 109573028
Muscle swelling 13.18 10.37 30 1007919 1055 109580295
Peritoneal dialysis complication 13.16 10.37 52 1007897 2494 109578856
Short stature 13.15 10.37 30 1007919 1057 109580293
Erectile dysfunction 13.14 10.37 107 1007842 18449 109562901
Premature delivery 13.11 10.37 369 1007580 30263 109551087
Vein disorder 13.10 10.37 100 1007849 6170 109575180
Cold sweat 13.01 10.37 133 1007816 21898 109559452
Polydipsia 12.99 10.37 32 1007917 7656 109573694
Product prescribing issue 12.96 10.37 66 1007883 12706 109568644
Viraemia 12.93 10.37 11 1007938 4091 109577259
Device issue 12.92 10.37 229 1007720 34306 109547044
Haemoglobin decreased 12.92 10.37 2513 1005436 246214 109335136
Eosinophil count increased 12.91 10.37 126 1007823 20932 109560418
Pharyngitis streptococcal 12.89 10.37 181 1007768 13096 109568254
Hepatic cancer 12.88 10.37 55 1007894 11101 109570249
Poor quality device used 12.83 10.37 5 1007944 2858 109578492
Blood prolactin increased 12.83 10.37 14 1007935 4628 109576722
Pulmonary function test abnormal 12.83 10.37 16 1007933 4984 109576366
Immune-mediated myocarditis 12.82 10.37 8 1007941 3490 109577860
Alcohol interaction 12.80 10.37 9 1007940 3685 109577665
Cervical incompetence 12.77 10.37 20 1007929 527 109580823
Pain in jaw 12.69 10.37 362 1007587 50815 109530535
Mycobacterium chelonae infection 12.67 10.37 6 1007943 3054 109578296
Hypoventilation 12.61 10.37 35 1007914 8046 109573304
Organising pneumonia 12.60 10.37 77 1007872 14166 109567184
Colitis microscopic 12.60 10.37 71 1007878 13323 109568027
Metastases to meninges 12.55 10.37 17 1007932 5111 109576239
Increased tendency to bruise 12.53 10.37 163 1007786 11595 109569755
Small for dates baby 12.50 10.37 22 1007927 640 109580710
Mite allergy 12.49 10.37 21 1007928 5782 109575568
Device malfunction 12.47 10.37 161 1007788 25397 109555953
Dermatitis exfoliative 12.46 10.37 57 1007892 11290 109570060
Hyperleukocytosis 12.42 10.37 8 1007941 3431 109577919
Device breakage 12.41 10.37 74 1007875 13695 109567655
Hypopituitarism 12.40 10.37 13 1007936 4377 109576973
Eye pruritus 12.37 10.37 217 1007732 32558 109548792
Autonomic nervous system imbalance 12.37 10.37 21 1007928 5759 109575591
Hyperventilation 12.36 10.37 41 1007908 8906 109572444
Obsessive-compulsive disorder 12.35 10.37 30 1007919 7211 109574139
Subileus 12.34 10.37 25 1007924 6412 109574938
Labyrinthitis 12.34 10.37 58 1007891 3004 109578346
Vascular pseudoaneurysm 12.30 10.37 12 1007937 4178 109577172
Encephalitis 12.28 10.37 111 1007838 18728 109562622
Benign ovarian tumour 12.24 10.37 18 1007931 448 109580902
Mass 12.22 10.37 249 1007700 19381 109561969
Anaesthetic complication 12.21 10.37 9 1007940 3597 109577753
Cartilage injury 12.21 10.37 38 1007911 1616 109579734
Brain death 12.21 10.37 26 1007923 6547 109574803
Device loosening 12.20 10.37 25 1007924 817 109580533
Large intestine perforation 12.19 10.37 95 1007854 16534 109564816
Respiration abnormal 12.18 10.37 47 1007902 9762 109571588
Placental disorder 12.15 10.37 28 1007921 993 109580357
Injection site swelling 12.13 10.37 684 1007265 61106 109520244
Polyhydramnios 12.11 10.37 42 1007907 1891 109579459
Autoimmune hepatitis 12.09 10.37 82 1007867 14722 109566628
Diffuse large B-cell lymphoma 12.04 10.37 90 1007859 15808 109565542
Pneumomediastinum 12.02 10.37 17 1007932 5019 109576331
Vertigo 12.00 10.37 658 1007291 86212 109495138
Hand fracture 12.00 10.37 120 1007829 8002 109573348
Knee operation 11.99 10.37 107 1007842 6915 109574435
Coronary artery bypass 11.99 10.37 23 1007926 6019 109575331
Device occlusion 11.97 10.37 85 1007864 15100 109566250
Porphyria acute 11.95 10.37 239 1007710 18541 109562809
Injection site warmth 11.93 10.37 224 1007725 17181 109564169
Tonic clonic movements 11.90 10.37 6 1007943 2946 109578404
Ventricular fibrillation 11.89 10.37 286 1007663 41027 109540323
Partial seizures 11.89 10.37 58 1007891 11291 109570059
Memory impairment 11.85 10.37 2005 1005944 194939 109386411
Malnutrition 11.83 10.37 176 1007773 27103 109554247
Dry eye 11.82 10.37 622 1007327 55171 109526179
Tooth fracture 11.79 10.37 177 1007772 12990 109568360
Cardiac septal defect 11.78 10.37 27 1007922 954 109580396
Dyspnoea exertional 11.78 10.37 803 1007146 103257 109478093
Antibody test positive 11.78 10.37 58 1007891 3062 109578288
Physical deconditioning 11.76 10.37 9 1007940 3528 109577822
Lymphocyte count decreased 11.75 10.37 415 1007534 56828 109524522
Long QT syndrome 11.74 10.37 30 1007919 7088 109574262
Spirometry abnormal 11.74 10.37 20 1007929 5477 109575873
Schizoaffective disorder 11.74 10.37 7 1007942 3129 109578221
Prescription drug used without a prescription 11.73 10.37 20 1007929 5476 109575874
Loss of libido 11.71 10.37 7 1007942 3126 109578224
Adverse drug reaction 11.71 10.37 1116 1006833 104443 109476907
Induced labour 11.67 10.37 26 1007923 901 109580449
Encephalitis toxic 11.67 10.37 14 1007935 284 109581066
Bone density abnormal 11.63 10.37 68 1007881 3835 109577515
Nasal oedema 11.57 10.37 104 1007845 6735 109574615
Foetal distress syndrome 11.57 10.37 21 1007928 626 109580724
Hepatosplenomegaly 11.54 10.37 29 1007920 6890 109574460
Scedosporium infection 11.51 10.37 4 1007945 2454 109578896
Congenital neuropathy 11.51 10.37 5 1007944 16 109581334
Renal transplant failure 11.50 10.37 5 1007944 2675 109578675
Hypervolaemia 11.48 10.37 353 1007596 49107 109532243
Cholestatic liver injury 11.47 10.37 32 1007917 7344 109574006
Delayed recovery from anaesthesia 11.47 10.37 3 1007946 2212 109579138
Prostate cancer stage II 11.47 10.37 3 1007946 2212 109579138
Bezoar 11.45 10.37 12 1007937 4042 109577308
Injection site rash 11.43 10.37 287 1007662 23132 109558218
Transient aphasia 11.41 10.37 22 1007927 687 109580663
COVID-19 11.40 10.37 2012 1005937 243048 109338302
Extravascular haemolysis 11.39 10.37 17 1007932 429 109580921
Pain of skin 11.39 10.37 122 1007827 19907 109561443
Mixed liver injury 11.38 10.37 64 1007885 12015 109569335
Skin plaque 11.38 10.37 68 1007881 12577 109568773
Tooth infection 11.36 10.37 274 1007675 21942 109559408
Cytomegalovirus test positive 11.34 10.37 30 1007919 7006 109574344
Lymph gland infection 11.34 10.37 21 1007928 636 109580714
Disseminated cryptococcosis 11.33 10.37 5 1007944 2652 109578698
Hemianopia 11.31 10.37 6 1007943 2862 109578488
Cestode infection 11.30 10.37 14 1007935 294 109581056
Hyporesponsive to stimuli 11.25 10.37 6 1007943 2854 109578496
Spondylolisthesis 11.21 10.37 66 1007883 3732 109577618
Panniculitis 11.19 10.37 202 1007747 15380 109565970
Lower gastrointestinal haemorrhage 11.17 10.37 111 1007838 18375 109562975
Blood urea increased 11.15 10.37 399 1007550 54558 109526792
Intraocular pressure increased 11.15 10.37 56 1007893 10820 109570530
Arthropod bite 11.13 10.37 136 1007813 9535 109571815
Joint irrigation 11.12 10.37 3 1007946 0 109581350
Haemorrhage subcutaneous 11.07 10.37 21 1007928 5518 109575832
Hypothyroidism 11.06 10.37 547 1007402 72352 109508998
Parainfluenzae virus infection 11.04 10.37 30 1007919 6944 109574406
Product substitution issue 10.99 10.37 146 1007803 22915 109558435
Diaphragmatic disorder 10.97 10.37 40 1007909 1846 109579504
Dermatitis exfoliative generalised 10.96 10.37 57 1007892 10915 109570435
Atrioventricular block second degree 10.95 10.37 38 1007911 8143 109573207
Pancreatic steatosis 10.90 10.37 39 1007910 1783 109579567
Influenza 10.90 10.37 1728 1006221 167373 109413977
Maternal exposure during breast feeding 10.85 10.37 71 1007878 4167 109577183
Cystoid macular oedema 10.83 10.37 6 1007943 2794 109578556
Skin haemorrhage 10.83 10.37 160 1007789 24667 109556683
Troponin T increased 10.82 10.37 14 1007935 4292 109577058
Chills 10.81 10.37 1547 1006402 189033 109392317
Placental insufficiency 10.75 10.37 31 1007918 1263 109580087
Multi-organ disorder 10.74 10.37 9 1007940 3372 109577978
N-terminal prohormone brain natriuretic peptide increased 10.72 10.37 25 1007924 6096 109575254
Eye infection 10.70 10.37 189 1007760 14329 109567021
Brain herniation 10.67 10.37 43 1007906 8820 109572530
Hyperoxaluria 10.67 10.37 15 1007934 358 109580992
Extradural haematoma 10.66 10.37 9 1007940 3360 109577990
Toothache 10.66 10.37 286 1007663 23289 109558061
Stupor 10.66 10.37 39 1007910 8226 109573124
Liver disorder 10.65 10.37 1466 1006483 140777 109440573
Radiation inflammation 10.61 10.37 27 1007922 1021 109580329
Metastases to peritoneum 10.58 10.37 22 1007927 5588 109575762
Intestinal pseudo-obstruction 10.58 10.37 9 1007940 3347 109578003
Hepatic siderosis 10.55 10.37 10 1007939 153 109581197
Alcohol abuse 10.46 10.37 18 1007931 4911 109576439
Nail injury 10.46 10.37 23 1007926 790 109580560
Allodynia 10.45 10.37 3 1007946 2080 109579270
Dyslipidaemia 10.44 10.37 94 1007855 15871 109565479
Aspartate aminotransferase increased 10.43 10.37 1287 1006662 158649 109422701
Gastrointestinal perforation 10.41 10.37 34 1007915 7422 109573928
Lip and/or oral cavity cancer 10.37 10.37 29 1007920 1161 109580189

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11GA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS
Ascorbic acid (vitamin C), plain
ATC A11GB01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS
Ascorbic acid (vitamin C), combinations
ATC G01AD03 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Organic acids
ATC S01XA15 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA CS M0001797 Ascorbic Acid
MeSH PA D000975 Antioxidants
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:23354 coenzyme
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:64577 flour treatment agent
CHEBI has role CHEBI:76924 plant metabolite
CHEBI has role CHEBI:77962 food antioxidant
CHEBI has role CHEBI:78006 food colour retention agent
CHEBI has role CHEBI:85046 skin lightening agent
CHEBI has role CHEBI:176497 geroprotector
FDA EPC N0000193618 Vitamin C
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:63247 reducing agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:83056 <em>Daphnia magna</em> metabolite
CHEBI has role CHEBI:27314 water-soluble vitamin (role)

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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ascorbic acid deficiency indication 76169001
Breastfeeding (mother) indication 413712001
Coronavirus infection off-label use 186747009
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Peptic ulcer contraindication 13200003 DOID:750
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Operation on stomach contraindication 16453004
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hypocupremia contraindication 19577007
Hyperphosphatemia contraindication 20165001 DOID:0050459
Sunburn contraindication 23346002
Acute vomiting contraindication 23971007
Multiple sclerosis contraindication 24700007 DOID:2377
Gastroenteritis contraindication 25374005 DOID:2326
Acute tuberculosis contraindication 25629007
Hypervitaminosis D contraindication 27712000 DOID:9971
Complete atrioventricular block contraindication 27885002
Toxic megacolon contraindication 28536002 DOID:1770
Dental fluorosis contraindication 30265004
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Hemosiderosis contraindication 39011001 DOID:12119
Gastrointestinal ulcer contraindication 40845000
Toxic colitis contraindication 42359007
Hypokalemia contraindication 43339004
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hyperlipidemia contraindication 55822004 DOID:1168
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Leber's optic atrophy contraindication 58610003 DOID:705
Hemolytic anemia contraindication 61261009 DOID:583
Allergic rhinitis contraindication 61582004
Hypervitaminosis A contraindication 64559002 DOID:9972
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Rheumatoid arthritis contraindication 69896004 DOID:7148
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperchloremia contraindication 74450001
Third degree burn injury contraindication 80247002
Intestinal obstruction contraindication 81060008 DOID:8437
Atrophic gastritis contraindication 84568007 DOID:8929
Human immunodeficiency virus infection contraindication 86406008 DOID:526
Wilson's disease contraindication 88518009
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Leukemia, disease contraindication 93143009 DOID:1240
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Gastrointestinal obstruction contraindication 126765001
Hb SS disease contraindication 127040003 DOID:10923
Seizure disorder contraindication 128613002
Osteolysis contraindication 203522001
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Esophageal dysmotility contraindication 266434009 DOID:9192
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Gastric retention contraindication 307227006
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
At risk for aspiration contraindication 371736008
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Denuded skin contraindication 418242004
Severe dehydration contraindication 450316000
Acute exacerbation of asthma contraindication 708038006
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Malabsorption States contraindication
Repeated Blood Transfusions contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.02 acidic
pKa2 9.62 acidic
pKa3 11.85 acidic
pKa4 12.53 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 10792306 March 9, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 11529368 March 9, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 9592252 Aug. 11, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 10918723 Sept. 10, 2033 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 12083179 Sept. 10, 2033 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 9326969 Sept. 10, 2033 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML MULTIPLE VITAMINS INJECTION ADULT APOTEX A210672 April 9, 2026 RX SOLUTION INTRAVENOUS Dec. 1, 2026 COMPETITIVE GENERIC THERAPY
80MG/VIAL;0.02MG/VIAL;400 IU/VIAL;0.001MG/VIAL;5MG/VIAL;0.14MG/VIAL;17MG/VIAL;1MG/VIAL;1.4MG/VIAL;1.2MG/VIAL;7 IU/VIAL;2,300 IU/VIAL;0.2MG/VIAL MULTIPLE VITAMINS INJECTION PEDIATRIC APOTEX A210671 April 21, 2026 RX INJECTABLE INTRAVENOUS Dec. 21, 2026 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tyrosinase Enzyme IC50 4.49 CHEMBL
Prolyl 4-hydroxylase subunit alpha-1 Enzyme WOMBAT-PK
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Enzyme WOMBAT-PK
Solute carrier family 23 member 2 Transporter WOMBAT-PK
Solute carrier family 23 member 1 Transporter WOMBAT-PK
Urease Enzyme IC50 5.07 CHEMBL
Pancreatic alpha-amylase Enzyme IC50 4.58 CHEMBL

External reference:

IDSource
4017646 VUID
N0000146025 NUI
D00018 KEGG_DRUG
134-03-2 SECONDARY_CAS_RN
5743-28-2 SECONDARY_CAS_RN
4017471 VANDF
4017472 VANDF
4017646 VANDF
4021716 VANDF
4026966 VANDF
C0003968 UMLSCUI
CHEBI:29073 CHEBI
ASC PDB_CHEM_ID
CHEMBL196 ChEMBL_ID
CHEMBL591665 ChEMBL_ID
CHEMBL2146095 ChEMBL_ID
D001205 MESH_DESCRIPTOR_UI
DB00126 DRUGBANK_ID
C069207 MESH_SUPPLEMENTAL_RECORD_UI
372 INN_ID
PQ6CK8PD0R UNII
54670067 PUBCHEM_CID
DB14482 DRUGBANK_ID
DB14483 DRUGBANK_ID
1151 RXNORM
1132 MMSL
11881 MMSL
32646 MMSL
4221 MMSL
5471 MMSL
5687 MMSL
6032 MMSL
72299 MMSL
NOCODE MMSL
d00426 MMSL
001010 NDDF
001011 NDDF
001012 NDDF
126230002 SNOMEDCT_US
126231003 SNOMEDCT_US
43706004 SNOMEDCT_US
46123006 SNOMEDCT_US
4781 IUPHAR_LIGAND_ID
174 INN_ID
PQ6CK8PD0R INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 120 mg ORAL unapproved drug other 17 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 120 mg ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 120 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 120 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 120 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 120 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 120 mg ORAL Unapproved drug other 11 sections
Antiflu Kids HUMAN OTC DRUG LABEL 3 0280-0046 POWDER, FOR SOLUTION 50 mg ORAL Export only 2 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 30 mg ORAL unapproved drug other 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 60 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OBCaplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 70 mg ORAL unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 12 mg ORAL UNAPPROVED DRUG OTHER 13 sections
VitafolUltra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 30 mg ORAL unapproved drug other 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite OneCaplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 300 mg ORAL unapproved drug other 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 30 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 60 mg ORAL unapproved drug other 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 100 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 500 mg ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 70 mg ORAL UNAPPROVED DRUG OTHER 6 sections
Acetaminophen, Ascorbic acid, Chlorpheniramine Maleate HUMAN OTC DRUG LABEL 3 10267-2949 POWDER, FOR SOLUTION 50 mg ORAL Export only 1 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 120 mg ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 120 mg ORAL UNAPPROVED DRUG OTHER 7 sections
JBA Collagen-Electrolyte Mocktail HUMAN OTC DRUG LABEL 12 13411-848 POWDER 100 mg ORAL unapproved drug other 6 sections
St. Paul Brands Verestor HUMAN OTC DRUG LABEL 7 13411-861 CAPSULE 100 mg ORAL unapproved drug other 8 sections