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nicotinamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
nicotinic acid or nicotinoyl alcohol derivatives	1906	98-92-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: niacinamide nicotinamide 3-pyridinecarboxamide	An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. Molecular weight: 122.13 Formula: C6H6N2O CLOGP: -0.21 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 55.98 ALOGS: -0.39 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

niacinamide
nicotinamide
3-pyridinecarboxamide

An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.

Molecular weight: 122.13
Formula: C6H6N2O
CLOGP: -0.21
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 55.98
ALOGS: -0.39
ROTB: 1

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.15	g	O

ADMET properties:

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Property	Value	Reference
S (Water solubility)	1000 mg/mL	Benet LZ, Broccatelli F, Oprea TI
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI

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Approvals:

Date	Agency	Company	Orphan
Feb. 20, 1953	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	1778.79	10.42	4410	527521	179316	62777775
Systemic lupus erythematosus	1672.21	10.42	4671	527260	204247	62752844
Glossodynia	1479.07	10.42	4048	527883	174828	62782263
Hand deformity	1206.41	10.42	3495	528436	155962	62801129
Arthropathy	1126.17	10.42	4414	527517	230378	62726713
Abdominal discomfort	1052.41	10.42	5387	526544	315498	62641593
Alopecia	1027.68	10.42	5551	526380	331985	62625106
Wound	999.80	10.42	3325	528606	159938	62797153
Completed suicide	957.39	10.42	68	531863	145605	62811486
Rheumatoid arthritis	896.54	10.42	4353	527578	249466	62707625

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid arthritis	551.64	10.18	831	182603	37407	34736090
Drug abuse	378.03	10.18	40	183394	99056	34674441
Toxicity to various agents	303.65	10.18	363	183071	199999	34573498
Completed suicide	277.49	10.18	85	183349	98083	34675414
Foetal exposure during pregnancy	266.38	10.18	606	182828	37495	34736002
Arthralgia	241.11	10.18	1622	181812	168419	34605078
Psoriatic arthropathy	195.22	10.18	363	183071	19435	34754062
Drug interaction	178.60	10.18	599	182835	225347	34548150
Sickle cell anaemia with crisis	141.37	10.18	138	183296	3915	34769582
Joint swelling	139.14	10.18	653	182781	59237	34714260

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid arthritis	1226.83	10.05	3660	540275	204810	78995643
Completed suicide	1168.88	10.05	149	543786	245618	78954835
Toxicity to various agents	1020.40	10.05	828	543107	420712	78779741
Arthropathy	977.50	10.05	3041	540894	174070	79026383
Pemphigus	953.66	10.05	2102	541833	97480	79102973
Systemic lupus erythematosus	939.83	10.05	2355	541580	118794	79081659
Joint swelling	934.28	10.05	4172	539763	284474	78915979
Hand deformity	916.54	10.05	2123	541812	101796	79098657
Synovitis	888.64	10.05	2649	541286	148085	79052368
Glossodynia	822.74	10.05	2029	541906	101308	79099145

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A11HA01	ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations
CHEBI has role	CHEBI:22586	antioxidants
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:25212	metabolites
CHEBI has role	CHEBI:61115	histone deacetylase inhibitors
CHEBI has role	CHEBI:62913	PARP
CHEBI has role	CHEBI:63726	neuroprotective agents
CHEBI has role	CHEBI:67079	anti-inflammatory agents
CHEBI has role	CHEBI:71181	Sir2 inhibitors
CHEBI has role	CHEBI:75771	Mus musculus metabolites

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Acne vulgaris	indication	88616000
Pellagra	indication	418186002	DOID:8457
Niacin deficiency	indication	418279001
Methemoglobinemia	off-label use	38959009	DOID:10783
Goiter	contraindication	3716002	DOID:12176
Peptic ulcer	contraindication	13200003	DOID:750
Hyperkalemia	contraindication	14140009
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Hashimoto thyroiditis	contraindication	21983002
Acute tuberculosis	contraindication	25629007

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.95	acidic
pKa2	3.41	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Hydroxycarboxylic acid receptor 2	GPCR	Q8TDS4	HCAR2_HUMAN			WOMBAT-PK
Hydroxycarboxylic acid receptor 3	GPCR	P49019	HCAR3_HUMAN			WOMBAT-PK
Nicotinamide N-methyltransferase	Enzyme	P40261	NNMT_HUMAN			WOMBAT-PK
Nicotinate-nucleotide pyrophosphorylase [carboxylating]	Enzyme	Q15274	NADC_HUMAN			WOMBAT-PK
NAD-dependent protein deacetylase sirtuin-1	Enzyme	Q96EB6	SIR1_HUMAN	IC50	4.30	CHEMBL
NAD-dependent protein deacetylase sirtuin-2	Enzyme	Q8IXJ6	SIR2_HUMAN	IC50	5.92	CHEMBL
NAD-dependent deacetylase sirtuin 3	Enzyme	Q9NTG7	SIR3_HUMAN	IC50	4.85	CHEMBL
NAD-dependent protein deacylase sirtuin-5, mitochondrial	Enzyme	Q9NXA8	SIR5_HUMAN	IC50	4.33	CHEMBL
Sterile alpha and TIR motif-containing protein 1	Unclassified	Q6SZW1	SARM1_HUMAN	IC50	4.36	CHEMBL
Fatty-acid amide hydrolase 1	Enzyme		FAAH1_RAT	IC50	5.48	CHEMBL

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External reference:

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ID	Source
NCA	PDB_CHEM_ID
001055	NDDF
173196005	SNOMEDCT_US
25X51I8RD4	UNII
4017632	VANDF
4017718	VANDF
4020285	VUID
4020285	VANDF
404	INN_ID
4947	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
BACMIN	HUMAN PRESCRIPTION DRUG LABEL	19	0682-3001	TABLET, COATED	100 mg	ORAL	UNAPPROVED DRUG OTHER	10 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	20 mg	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	20 mg	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN OTC DRUG LABEL	14	0178-0829	TABLET	20 mg	ORAL	Unapproved drug other	11 sections
CitraNatal DHA	HUMAN OTC DRUG LABEL	14	0178-0898	TABLET	20 mg	ORAL	Unapproved drug other	11 sections
CitraNatal Rx	HUMAN PRESCRIPTION DRUG LABEL	13	0178-0858	TABLET	20 mg	ORAL	Unapproved drug other	12 sections
CitraNatal Rx	HUMAN PRESCRIPTION DRUG LABEL	14	0178-0859	TABLET	20 mg	ORAL	Unapproved drug other	9 sections
Dialyvite	HUMAN PRESCRIPTION DRUG LABEL	9	10542-010	TABLET, COATED	20 mg	ORAL	Unapproved drug other	7 sections
Dialyvite	HUMAN PRESCRIPTION DRUG LABEL	9	10542-010	TABLET, COATED	20 mg	ORAL	Unapproved drug other	7 sections
Dialyvite 3000	HUMAN PRESCRIPTION DRUG LABEL	12	10542-014	TABLET, COATED	20 mg	ORAL	Unapproved drug other	7 sections

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