nicotinamide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
nicotinic acid or nicotinoyl alcohol derivatives 1906 98-92-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • niacinamide
  • nicotinamide
  • 3-pyridinecarboxamide
An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
  • Molecular weight: 122.13
  • Formula: C6H6N2O
  • CLOGP: -0.21
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 55.98
  • ALOGS: -0.39
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1000 mg/mL Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1056.60 9.69 3701 300525 236514 46145322
Pemphigus 902.46 9.69 1285 302941 43989 46337847
Systemic lupus erythematosus 760.54 9.69 1453 302773 63727 46318109
Completed suicide 720.90 9.69 62 304164 145858 46235978
Glossodynia 595.47 9.69 1051 303175 43322 46338514
Hand deformity 438.32 9.69 799 303427 33775 46348061
Toxicity to various agents 433.91 9.69 444 303782 211322 46170514
Maternal exposure during pregnancy 424.46 9.69 1551 302675 100998 46280838
Alopecia 379.34 9.69 2071 302155 160343 46221493
Arthropathy 369.99 9.69 1304 302922 83396 46298440
Abdominal discomfort 360.03 9.69 1938 302288 149227 46232609
Joint swelling 333.17 9.69 2034 302192 164039 46217797
Pain 326.87 9.69 4629 299597 472319 45909517
Infusion related reaction 317.26 9.69 1404 302822 99804 46282032
Death 313.81 9.69 1128 303098 334420 46047416
Drug abuse 310.07 9.69 28 304198 63380 46318456
Arthralgia 293.12 9.69 3644 300582 360959 46020877
Wound 274.13 9.69 753 303473 42049 46339787
Intentional overdose 260.32 9.69 53 304173 64891 46316945
Exposure during pregnancy 256.52 9.69 1386 302840 106826 46275010
Drug interaction 244.16 9.69 607 303619 202487 46179349
Synovitis 233.59 9.69 901 303325 60174 46321662
Anti-cyclic citrullinated peptide antibody positive 209.89 9.69 416 303810 18729 46363107
Contraindicated product administered 209.44 9.69 1053 303173 78894 46302942
Nasopharyngitis 198.83 9.69 1697 302529 152301 46229535
Overdose 190.82 9.69 230 303996 101749 46280087
Pericarditis 187.28 9.69 454 303772 23473 46358363
Swelling 183.94 9.69 1415 302811 123096 46258740
Rheumatoid factor positive 179.54 9.69 406 303820 20055 46361781
Suicide attempt 172.78 9.69 71 304155 54965 46326871
Febrile neutropenia 169.12 9.69 221 304005 94406 46287430
Hip arthroplasty 161.83 9.69 362 303864 17750 46364086
Acute kidney injury 155.97 9.69 900 303326 234955 46146881
Cardiac arrest 150.65 9.69 222 304004 90177 46291659
Red blood cell sedimentation rate abnormal 147.71 9.69 295 303931 13354 46368482
Musculoskeletal stiffness 147.11 9.69 1118 303108 96875 46284961
Knee arthroplasty 146.21 9.69 411 303815 23254 46358582
Product use issue 141.62 9.69 1079 303147 93565 46288271
Injection site erythema 141.09 9.69 899 303327 73528 46308308
C-reactive protein abnormal 139.94 9.69 378 303848 20892 46360944
Drug hypersensitivity 131.12 9.69 990 303236 242835 46139001
Sickle cell anaemia with crisis 125.04 9.69 142 304084 3850 46377986
Injection site pain 123.87 9.69 1153 303073 105999 46275837
Discomfort 123.77 9.69 617 303609 46053 46335783
Pregnancy 121.11 9.69 421 303805 26716 46355120
Depressed level of consciousness 111.25 9.69 88 304138 47481 46334355
Device expulsion 109.26 9.69 23 304203 27519 46354317
Injection site pruritus 106.50 9.69 527 303699 39216 46342620
Malignant neoplasm progression 104.72 9.69 163 304063 64763 46317073
Blood pressure fluctuation 101.86 9.69 431 303795 30017 46351819
Cardiac failure 100.63 9.69 233 303993 79715 46302121
Bradycardia 99.89 9.69 174 304052 66124 46315712
Lactic acidosis 99.73 9.69 48 304178 33861 46347975
Arthritis 98.58 9.69 850 303376 76466 46305370
Hyponatraemia 96.81 9.69 337 303889 100995 46280841
Therapeutic product effect decreased 95.52 9.69 889 303337 81712 46300124
Psoriatic arthropathy 95.08 9.69 479 303747 35900 46345936
Respiratory arrest 94.77 9.69 51 304175 33765 46348071
Injection site swelling 93.72 9.69 514 303712 39813 46342023
Abortion spontaneous 93.32 9.69 544 303682 43102 46338734
Injection site reaction 93.15 9.69 582 303644 47267 46334569
Electrocardiogram QT prolonged 88.49 9.69 123 304103 51202 46330634
Drug reaction with eosinophilia and systemic symptoms 88.17 9.69 41 304185 29507 46352329
Disease progression 81.69 9.69 312 303914 90988 46290848
Osteoarthritis 81.22 9.69 686 303540 61339 46320497
Sopor 79.81 9.69 16 304210 19812 46362024
Basal cell carcinoma 79.72 9.69 304 303922 20183 46361653
Cardio-respiratory arrest 77.34 9.69 172 304054 59697 46322139
Drug ineffective 76.76 9.69 5259 298967 672579 45709257
Duodenal ulcer perforation 76.02 9.69 170 304056 8332 46373504
Confusional state 75.87 9.69 671 303555 159221 46222615
Sinusitis 75.25 9.69 1226 303000 128542 46253294
Product quality issue 73.69 9.69 74 304152 35574 46346262
Neutropenia 72.87 9.69 590 303636 142614 46239222
Agitation 71.75 9.69 159 304067 55256 46326580
Helicobacter infection 71.68 9.69 203 304023 11533 46370303
Intentional self-injury 71.38 9.69 34 304192 24132 46357704
Renal failure 70.98 9.69 441 303785 113153 46268683
Rhabdomyolysis 70.69 9.69 102 304124 41807 46340029
Anxiety 69.60 9.69 804 303422 181153 46200683
Caesarean section 69.30 9.69 252 303974 16351 46365485
Dyspnoea 68.20 9.69 2709 301517 512839 45868997
Joint effusion 67.03 9.69 201 304025 11794 46370042
Disability assessment scale score increased 65.88 9.69 77 304149 2155 46379681
Fatigue 65.23 9.69 4702 299524 603995 45777841
Tremor 63.72 9.69 466 303760 115173 46266663
Hypotension 63.35 9.69 1100 303126 231489 46150347
Psoriasis 62.06 9.69 784 303442 77820 46304016
Treatment failure 59.46 9.69 894 303332 92193 46289643
Injection site bruising 58.80 9.69 416 303810 35220 46346616
Sedation 57.96 9.69 39 304187 22871 46358965
Impaired healing 57.22 9.69 423 303803 36320 46345516
Joint laxity 56.43 9.69 69 304157 2027 46379809
Drug dependence 54.34 9.69 31 304195 19870 46361966
Drug withdrawal syndrome 54.17 9.69 59 304167 27325 46354511
Tachycardia 54.14 9.69 403 303823 99219 46282617
Serotonin syndrome 53.91 9.69 47 304179 24173 46357663
Lower respiratory tract infection 53.07 9.69 571 303655 54518 46327318
Localised infection 53.05 9.69 300 303926 23501 46358335
Live birth 52.98 9.69 168 304058 10162 46371674
Hepatic failure 51.89 9.69 86 304140 33330 46348506
Oropharyngeal pain 51.59 9.69 723 303503 73445 46308391
Osteoporosis 51.50 9.69 446 303780 40162 46341674
Red blood cell sedimentation rate increased 51.34 9.69 289 303937 22600 46359236
Blood pressure diastolic abnormal 50.93 9.69 121 304105 6173 46375663
Asthma 50.85 9.69 368 303858 91174 46290662
Delirium 50.54 9.69 104 304122 37124 46344712
Cholestasis 49.89 9.69 61 304165 26832 46355004
Hepatic enzyme increased 49.74 9.69 779 303447 81008 46300828
Hypoglycaemia 49.07 9.69 185 304041 54164 46327672
Cytomegalovirus infection 48.49 9.69 29 304197 18115 46363721
Premature labour 48.43 9.69 173 304053 11126 46370710
Encephalopathy 48.04 9.69 91 304135 33498 46348338
Pulmonary arterial hypertension 47.90 9.69 59 304167 25869 46355967
Constipation 47.80 9.69 822 303404 173275 46208561
Poisoning 47.35 9.69 16 304210 13978 46367858
Injection site rash 46.93 9.69 216 304010 15597 46366239
Hepatocellular injury 46.75 9.69 75 304151 29447 46352389
Maternal drugs affecting foetus 46.74 9.69 108 304118 5410 46376426
Neck deformity 46.65 9.69 59 304167 1795 46380041
Pre-eclampsia 46.62 9.69 136 304090 7858 46373978
Rheumatoid nodule 46.54 9.69 147 304079 8873 46372963
Metabolic acidosis 46.42 9.69 116 304110 38664 46343172
Loss of personal independence in daily activities 46.26 9.69 573 303653 56610 46325226
Vomiting 46.07 9.69 2447 301779 450347 45931489
Pain in extremity 45.73 9.69 2092 302134 256588 46125248
Hepatic function abnormal 45.18 9.69 98 304128 34323 46347513
Juvenile idiopathic arthritis 44.34 9.69 89 304137 4043 46377793
Foetal exposure during pregnancy 43.97 9.69 347 303879 30400 46351436
Respiratory failure 43.59 9.69 401 303825 94415 46287421
Diabetic ketoacidosis 43.44 9.69 33 304193 18177 46363659
Herpes zoster 43.39 9.69 652 303574 67220 46314616
Nausea 43.25 9.69 3876 300350 683578 45698258
Gestational diabetes 43.24 9.69 124 304102 7095 46374741
Dizziness 42.47 9.69 1800 302426 338614 46043222
Peripheral swelling 42.45 9.69 1339 302887 156732 46225104
Blood pressure systolic abnormal 42.43 9.69 104 304122 5413 46376423
Altered state of consciousness 42.23 9.69 54 304172 23294 46358542
Osteonecrosis of jaw 41.88 9.69 102 304124 34300 46347536
Femur fracture 41.15 9.69 395 303831 36602 46345234
Shock 41.11 9.69 49 304177 21796 46360040
Foot deformity 40.93 9.69 204 304022 15221 46366615
Drug resistance 40.77 9.69 32 304194 17336 46364500
Influenza 40.62 9.69 812 303414 88458 46293378
Product use in unapproved indication 40.12 9.69 385 303841 89888 46291948
Renal impairment 39.86 9.69 302 303924 74070 46307766
Ejection fraction decreased 39.69 9.69 35 304191 17902 46363934
Disturbance in attention 39.67 9.69 92 304134 31468 46350368
Hyperhidrosis 39.64 9.69 381 303845 88927 46292909
General physical health deterioration 39.53 9.69 524 303702 115245 46266591
Hallucination 39.50 9.69 179 304047 49772 46332064
Somnolence 38.88 9.69 752 303474 155769 46226067
Hyperglycaemia 38.86 9.69 109 304117 34962 46346874
Asthenia 38.76 9.69 1645 302581 309430 46072406
Hyperkalaemia 38.75 9.69 184 304042 50525 46331311
Intentional product misuse 38.40 9.69 167 304059 46961 46334875
Palmar-plantar erythrodysaesthesia syndrome 38.35 9.69 46 304180 20405 46361431
Nodule 38.35 9.69 202 304024 15403 46366433
Emotional distress 38.21 9.69 90 304136 30617 46351219
Multiple organ dysfunction syndrome 38.14 9.69 190 304036 51520 46330316
Tuberculosis 38.04 9.69 150 304076 10115 46371721
Mydriasis 37.61 9.69 11 304215 10542 46371294
Musculoskeletal pain 37.48 9.69 654 303572 69474 46312362
Hypoxia 37.36 9.69 192 304034 51646 46330190
Hypokalaemia 37.19 9.69 380 303846 87644 46294192
Blood creatine phosphokinase increased 37.17 9.69 78 304148 27646 46354190
Syncope 37.02 9.69 471 303755 104332 46277504
Anaphylactic reaction 37.00 9.69 199 304027 52913 46328923
Therapeutic response decreased 36.93 9.69 437 303789 42708 46339128
Insomnia 36.35 9.69 808 303418 164116 46217720
Bone erosion 35.81 9.69 139 304087 9304 46372532
Restlessness 35.76 9.69 70 304156 25454 46356382
Disorientation 35.76 9.69 122 304104 36796 46345040
Cardiac failure congestive 35.58 9.69 404 303822 91346 46290490
Ventricular septal defect 35.33 9.69 80 304146 3954 46377882
Urticaria 35.19 9.69 548 303678 117344 46264492
Neoplasm progression 34.99 9.69 76 304150 26607 46355229
Bronchitis 34.84 9.69 921 303305 105058 46276778
Limb deformity 34.81 9.69 74 304152 3502 46378334
Hypothermia 34.68 9.69 18 304208 12165 46369671
Multiple sclerosis relapse 34.49 9.69 149 304077 41976 46339860
Pulmonary embolism 34.38 9.69 499 303727 108086 46273750
Premature delivery 34.32 9.69 254 303972 21815 46360021
Infective pulmonary exacerbation of cystic fibrosis 33.81 9.69 14 304212 10793 46371043
Weight increased 33.70 9.69 1351 302875 163122 46218714
Malignant melanoma 33.55 9.69 144 304082 10090 46371746
Respiratory depression 33.23 9.69 17 304209 11583 46370253
Drug intolerance 32.99 9.69 1220 303006 145829 46236007
Injection site warmth 32.97 9.69 177 304049 13595 46368241
Blood pressure systolic increased 32.83 9.69 309 303917 28478 46353358
Small for dates baby 32.83 9.69 73 304153 3564 46378272
Thrombocytopenia 32.71 9.69 604 303622 125977 46255859
No adverse event 32.56 9.69 114 304112 34117 46347719
Condition aggravated 32.36 9.69 1928 302298 243124 46138712
Grip strength decreased 32.09 9.69 126 304100 8480 46373356
Arthritis infective 31.77 9.69 89 304137 5024 46376812
Coma 31.70 9.69 236 303990 58113 46323723
Smear cervix abnormal 31.68 9.69 58 304168 2458 46379378
Blood pressure diastolic decreased 31.59 9.69 179 304047 14032 46367804
Heart rate decreased 31.56 9.69 331 303895 31392 46350444
Extrapyramidal disorder 31.56 9.69 17 304209 11251 46370585
Seizure 31.54 9.69 588 303638 122466 46259370
Cerebral haemorrhage 30.83 9.69 89 304137 28282 46353554
Neck mass 30.75 9.69 67 304159 3226 46378610
Myalgia 30.67 9.69 591 303635 122497 46259339
Oral herpes 30.62 9.69 224 304002 19166 46362670
Fibromyalgia 30.62 9.69 368 303858 36095 46345741
Disseminated intravascular coagulation 30.36 9.69 48 304178 18957 46362879
Posterior reversible encephalopathy syndrome 29.53 9.69 33 304193 15108 46366728
Premature rupture of membranes 29.48 9.69 79 304147 4344 46377492
Developmental hip dysplasia 29.42 9.69 39 304187 1244 46380592
Inflammation 29.41 9.69 464 303762 48317 46333519
Accidental overdose 29.01 9.69 54 304172 20012 46361824
Ventricular tachycardia 28.90 9.69 41 304185 16926 46364910
Myocardial infarction 28.54 9.69 455 303771 97073 46284763
Enthesopathy 28.52 9.69 81 304145 4609 46377227
Ventricular fibrillation 28.51 9.69 20 304206 11476 46370360
Joint stiffness 28.47 9.69 286 303940 26822 46355014
Neutrophil count decreased 28.46 9.69 166 304060 43260 46338576
Loss of consciousness 28.42 9.69 515 303711 107723 46274113
Skin ulcer 28.32 9.69 330 303896 32128 46349708
Joint destruction 28.22 9.69 62 304164 3002 46378834
Angioedema 28.19 9.69 146 304080 39196 46342640
Anaphylactic shock 28.06 9.69 56 304170 20218 46361618
Multiple fractures 28.06 9.69 90 304136 5477 46376359
Torsade de pointes 27.77 9.69 23 304203 12131 46369705
Acute hepatic failure 27.72 9.69 33 304193 14688 46367148
Gastroenteritis viral 27.30 9.69 207 304019 17912 46363924
Aspartate aminotransferase increased 27.30 9.69 355 303871 78345 46303491
Inappropriate antidiuretic hormone secretion 27.21 9.69 31 304195 14071 46367765
Surgery 27.08 9.69 297 303929 28488 46353348
Postoperative wound infection 27.05 9.69 121 304105 8632 46373204
Synovial cyst 26.94 9.69 107 304119 7239 46374597
Blood pressure diastolic increased 26.92 9.69 93 304133 5881 46375955
Brain oedema 26.83 9.69 25 304201 12453 46369383
Unresponsive to stimuli 26.83 9.69 113 304113 32061 46349775
Toxic skin eruption 26.42 9.69 25 304201 12362 46369474
Mental status changes 26.37 9.69 143 304083 37945 46343891
Metastases to liver 26.34 9.69 55 304171 19530 46362306
Skin papilloma 26.25 9.69 73 304153 4103 46377733
Swollen joint count increased 26.12 9.69 52 304174 2348 46379488
Dyspnoea exertional 26.10 9.69 206 304020 50083 46331753
Psychotic disorder 26.04 9.69 69 304157 22552 46359284
Abnormal behaviour 25.98 9.69 62 304164 20996 46360840
Tenosynovitis stenosans 25.90 9.69 46 304180 1903 46379933
Rash 25.88 9.69 2677 301549 353835 46028001
Contusion 25.85 9.69 750 303476 86737 46295099
Skin cancer 25.80 9.69 120 304106 8703 46373133
Latent tuberculosis 25.72 9.69 46 304180 1914 46379922
Rheumatic fever 25.59 9.69 57 304169 2786 46379050
Drug level increased 25.47 9.69 51 304175 18390 46363446
Schizophrenia 25.39 9.69 12 304214 8556 46373280
Metastases to bone 25.29 9.69 47 304179 17429 46364407
Blood pressure increased 25.14 9.69 1037 303189 125629 46256207
Tenderness 24.96 9.69 192 304034 16689 46365147
Leukopenia 24.93 9.69 305 303921 68038 46313798
Febrile bone marrow aplasia 24.74 9.69 7 304219 6855 46374981
Squamous cell carcinoma 24.72 9.69 109 304117 7727 46374109
Cellulitis 24.60 9.69 616 303610 69672 46312164
Decreased appetite 24.52 9.69 1023 303203 192813 46189023
Gamma-glutamyltransferase increased 24.34 9.69 115 304111 31625 46350211
Respiratory distress 24.27 9.69 116 304110 31800 46350036
Product administration error 24.23 9.69 58 304168 19623 46362213
Polyhydramnios 23.81 9.69 45 304181 1954 46379882
Acute generalised exanthematous pustulosis 23.80 9.69 16 304210 9389 46372447
Placental disorder 23.75 9.69 37 304189 1372 46380464
Blood alkaline phosphatase increased 23.58 9.69 156 304070 39453 46342383
Alanine aminotransferase increased 23.49 9.69 420 303806 88031 46293805
Pyrexia 23.37 9.69 1956 302270 346846 46034990
Blood bilirubin increased 23.30 9.69 129 304097 34055 46347781
Dehydration 23.25 9.69 828 303398 158712 46223124
Fracture 23.06 9.69 185 304041 16286 46365550
Jaundice 23.02 9.69 103 304123 28742 46353094
Arrhythmia 22.93 9.69 133 304093 34708 46347128
Off label use 22.83 9.69 2148 302078 377693 46004143
Pulmonary tuberculosis 22.51 9.69 75 304151 4656 46377180
Blood glucose increased 22.41 9.69 332 303894 71681 46310155
Agranulocytosis 22.39 9.69 72 304154 22113 46359723
Speech disorder 22.26 9.69 141 304085 36026 46345810
Cyst 22.19 9.69 145 304081 11955 46369881
Transplant rejection 22.12 9.69 18 304208 9578 46372258
Atrioventricular block complete 22.11 9.69 11 304215 7616 46374220
Complication of device insertion 22.10 9.69 3 304223 4941 46376895
Diarrhoea 22.08 9.69 3255 300971 556347 45825489
Suicidal ideation 21.96 9.69 248 303978 56134 46325702
Joint range of motion decreased 21.79 9.69 171 304055 14953 46366883
Haemoglobin decreased 21.69 9.69 1038 303188 127911 46253925
Dry eye 21.65 9.69 297 303929 30025 46351811
Blood pressure decreased 21.64 9.69 253 303973 56906 46324930
Synovial fluid analysis 21.58 9.69 35 304191 1344 46380492
Neurotoxicity 21.57 9.69 35 304191 13682 46368154
Wheezing 21.51 9.69 233 303993 53153 46328683
Deep vein thrombosis 21.43 9.69 378 303848 79395 46302441
Polyarthritis 21.40 9.69 92 304134 6450 46375386
Foetal death 21.36 9.69 113 304113 8630 46373206
Disability 21.25 9.69 126 304100 10041 46371795
Immunosuppression 21.19 9.69 101 304125 7399 46374437
Laryngitis 21.14 9.69 118 304108 9198 46372638
Cognitive disorder 21.09 9.69 147 304079 36736 46345100
Eosinophilia 21.09 9.69 60 304166 19157 46362679
Akathisia 21.08 9.69 12 304214 7702 46374134
Face oedema 20.87 9.69 60 304166 19093 46362743
Acute chest syndrome 20.85 9.69 22 304204 548 46381288
Aggression 20.80 9.69 77 304149 22667 46359169
International normalised ratio increased 20.80 9.69 200 304026 46683 46335153
Anaemia 20.65 9.69 1412 302814 254367 46127469
Tooth infection 20.60 9.69 144 304082 12142 46369694
Injection site haemorrhage 20.56 9.69 216 304010 20493 46361343
Cystitis 20.48 9.69 388 303838 41853 46339983
Immunodeficiency 20.46 9.69 151 304075 12955 46368881
Depression 20.41 9.69 903 303323 169201 46212635
Clear cell renal cell carcinoma 20.39 9.69 29 304197 990 46380846
Nightmare 20.37 9.69 49 304177 16549 46365287
Serum ferritin increased 20.23 9.69 78 304148 5205 46376631
Erythema multiforme 20.22 9.69 20 304206 9684 46372152
Body height below normal 20.20 9.69 40 304186 1799 46380037
Mouth ulceration 20.05 9.69 265 303961 26567 46355269
Asphyxia 20.02 9.69 5 304221 5321 46376515
Atrial septal defect 19.92 9.69 88 304138 6244 46375592
Joint injury 19.85 9.69 202 304024 19007 46362829
Neuroleptic malignant syndrome 19.83 9.69 26 304200 11096 46370740
Acute myeloid leukaemia 19.82 9.69 46 304180 15732 46366104
Foot fracture 19.80 9.69 205 304021 19377 46362459
Orthostatic hypotension 19.71 9.69 88 304138 24570 46357266
Fluid retention 19.69 9.69 225 304001 50821 46331015
Loose body in joint 19.60 9.69 29 304197 1027 46380809
Oedema 19.59 9.69 313 303913 66758 46315078
Cytokine release syndrome 19.57 9.69 8 304218 6215 46375621
Hypersensitivity 19.49 9.69 1181 303045 149140 46232696
Coagulopathy 19.40 9.69 59 304167 18440 46363396
Ascites 19.38 9.69 149 304077 36435 46345401
Injection site urticaria 19.33 9.69 139 304087 11828 46370008
Blood creatinine increased 19.28 9.69 366 303860 76037 46305799
Injection site haematoma 19.27 9.69 85 304141 6027 46375809
Plasma cell myeloma 19.20 9.69 191 304035 44287 46337549
Respiratory disorder 19.17 9.69 102 304124 27198 46354638
Gestational hypertension 19.17 9.69 43 304183 2112 46379724
Device dislocation 19.17 9.69 75 304151 21727 46360109
Chest discomfort 19.09 9.69 445 303781 89824 46292012
Cushingoid 18.90 9.69 86 304140 6180 46375656
Breast feeding 18.74 9.69 26 304200 867 46380969
Congenital arterial malformation 18.73 9.69 17 304209 350 46381486
Miosis 18.71 9.69 10 304216 6647 46375189
Stress cardiomyopathy 18.70 9.69 14 304212 7770 46374066
Thrombotic microangiopathy 18.63 9.69 16 304210 8290 46373546
Wheelchair user 18.59 9.69 63 304163 3945 46377891
Blood iron increased 18.45 9.69 32 304194 1299 46380537
Pharyngitis streptococcal 18.38 9.69 106 304120 8362 46373474
Graft versus host disease 18.36 9.69 10 304216 6578 46375258
Hallucination, auditory 18.31 9.69 26 304200 10730 46371106
Exomphalos 18.30 9.69 20 304206 519 46381317
Melaena 18.28 9.69 106 304120 27666 46354170
Bone disorder 18.07 9.69 205 304021 19828 46362008
Antinuclear antibody positive 18.06 9.69 85 304141 6195 46375641
Polyneuropathy 18.04 9.69 30 304196 11614 46370222
Bradyphrenia 18.04 9.69 9 304217 6221 46375615
Bronchospasm 18.01 9.69 48 304178 15659 46366177
Pancreatitis acute 17.99 9.69 92 304134 24780 46357056
Knee operation 17.95 9.69 70 304156 4696 46377140
Pulmonary fibrosis 17.85 9.69 205 304021 19887 46361949
Maternal exposure during breast feeding 17.78 9.69 49 304177 2740 46379096
Spinal stenosis 17.63 9.69 141 304085 12402 46369434
Substance abuse 17.55 9.69 3 304223 4164 46377672
Pancytopenia 17.47 9.69 699 303527 84359 46297477
Joint noise 17.43 9.69 53 304173 3134 46378702
Scleritis 17.42 9.69 50 304176 2862 46378974
Injury 17.40 9.69 193 304033 43834 46338002
Poor venous access 17.39 9.69 103 304123 8205 46373631
Fear 17.37 9.69 51 304175 16121 46365715
Status epilepticus 17.37 9.69 41 304185 13938 46367898
Diverticulitis 17.24 9.69 307 303919 32732 46349104
Hospitalisation 17.13 9.69 300 303926 63085 46318751
Rotator cuff repair 17.13 9.69 33 304193 1454 46380382
Dysarthria 17.04 9.69 159 304067 37339 46344497
Diabetes mellitus inadequate control 17.03 9.69 38 304188 13176 46368660
Injection site irritation 16.99 9.69 64 304162 4223 46377613
Carpal tunnel syndrome 16.98 9.69 168 304058 15691 46366145
Synovial disorder 16.90 9.69 24 304202 818 46381018
Viral infection 16.88 9.69 284 303942 29951 46351885
Device use error 16.86 9.69 6 304220 5075 46376761
Hiatus hernia 16.83 9.69 188 304038 18114 46363722
Arthritis bacterial 16.76 9.69 78 304148 5658 46376178
Acute graft versus host disease 16.75 9.69 3 304223 4027 46377809
Hyperuricaemia 16.66 9.69 5 304221 4712 46377124
Chronic kidney disease 16.62 9.69 178 304048 40693 46341143
Bone marrow failure 16.59 9.69 119 304107 29550 46352286
Vertigo 16.53 9.69 239 303987 51809 46330027
Ischaemic stroke 16.37 9.69 55 304171 16667 46365169
Ketoacidosis 16.32 9.69 3 304223 3952 46377884
Cholecystitis chronic 16.32 9.69 27 304199 10472 46371364
Post procedural infection 16.28 9.69 94 304132 7419 46374417
Rhinorrhoea 16.16 9.69 416 303810 47249 46334587
Tumour lysis syndrome 16.15 9.69 14 304212 7222 46374614
Human antichimeric antibody positive 16.11 9.69 31 304195 1365 46380471
Crying 15.98 9.69 77 304149 21064 46360772
Cardiogenic shock 15.96 9.69 54 304172 16330 46365506
Cervical incompetence 15.95 9.69 20 304206 603 46381233
Talipes 15.93 9.69 31 304195 1376 46380460
Stillbirth 15.93 9.69 84 304142 6407 46375429
Foetal distress syndrome 15.92 9.69 29 304197 1224 46380612
Mania 15.85 9.69 29 304197 10817 46371019
Antibody test positive 15.80 9.69 40 304186 2125 46379711
Bursitis 15.68 9.69 198 304028 19644 46362192
Bone density abnormal 15.67 9.69 50 304176 3034 46378802
Anhedonia 15.67 9.69 27 304199 10308 46371528
Pleural effusion 15.62 9.69 416 303810 82536 46299300
Tachypnoea 15.60 9.69 45 304181 14306 46367530
Cholestasis of pregnancy 15.55 9.69 27 304199 1097 46380739
Shock haemorrhagic 15.54 9.69 20 304206 8604 46373232
Immune reconstitution inflammatory syndrome 15.51 9.69 9 304217 5716 46376120
Catheter site pain 15.47 9.69 3 304223 3803 46378033
Ear infection 15.46 9.69 223 304003 22790 46359046
Pain in jaw 15.25 9.69 168 304058 38204 46343632
Pancreatitis 15.05 9.69 197 304029 43430 46338406
Dysgeusia 15.03 9.69 180 304046 40311 46341525
Rash maculo-papular 15.01 9.69 113 304113 27761 46354075
Device difficult to use 15.01 9.69 18 304208 7986 46373850
Cerebral infarction 14.95 9.69 90 304136 23276 46358560
Hypomania 14.88 9.69 5 304221 4383 46377453
Joint lock 14.84 9.69 38 304188 2033 46379803
Joint dislocation 14.78 9.69 124 304102 11062 46370774
Dyskinesia 14.77 9.69 119 304107 28806 46353030
Eye infection 14.75 9.69 106 304120 9017 46372819
Metastases to central nervous system 14.68 9.69 32 304194 11189 46370647
Carcinoma in situ of skin 14.65 9.69 12 304214 214 46381622
Obstructive airways disorder 14.62 9.69 42 304184 13370 46368466
Myopathy 14.60 9.69 22 304204 8859 46372977
Fracture delayed union 14.57 9.69 39 304187 2143 46379693
Pulmonary hypertension 14.54 9.69 157 304069 35836 46346000
Infection 14.51 9.69 1034 303192 132558 46249278
Palpitations 14.41 9.69 492 303734 94767 46287069
Dactylitis 14.39 9.69 27 304199 1166 46380670
Second primary malignancy 14.38 9.69 13 304213 6571 46375265
Weight decreased 14.38 9.69 1577 302649 209272 46172564
Lymphadenectomy 14.37 9.69 23 304203 873 46380963
Tenosynovitis 14.36 9.69 91 304135 7424 46374412
Skin laceration 14.36 9.69 184 304042 18318 46363518
Cartilage injury 14.35 9.69 32 304194 1565 46380271
Myoclonus 14.19 9.69 47 304179 14305 46367531
Vision blurred 14.17 9.69 403 303823 79305 46302531
Tardive dyskinesia 14.11 9.69 17 304209 7526 46374310
Sinus congestion 14.10 9.69 139 304087 12970 46368866
Hypomagnesaemia 13.97 9.69 86 304140 22124 46359712
Haemorrhage in pregnancy 13.94 9.69 32 304194 1596 46380240
Maternal exposure before pregnancy 13.89 9.69 62 304164 4419 46377417
Body temperature decreased 13.85 9.69 141 304085 13268 46368568
Stevens-Johnson syndrome 13.74 9.69 92 304134 23205 46358631
Withdrawal syndrome 13.73 9.69 66 304160 18068 46363768
Acidosis 13.70 9.69 33 304193 11141 46370695
Upper respiratory tract infection 13.68 9.69 525 303701 63031 46318805
Induced labour 13.66 9.69 23 304203 911 46380925
Hypertransaminasaemia 13.66 9.69 3 304223 3485 46378351
Complication associated with device 13.65 9.69 53 304173 15388 46366448
Frequent bowel movements 13.62 9.69 134 304092 12498 46369338
Sickle cell anaemia 13.58 9.69 18 304208 574 46381262
Ingrown hair 13.57 9.69 16 304210 452 46381384
Renal injury 13.51 9.69 26 304200 9515 46372321
Injection site extravasation 13.49 9.69 83 304143 6702 46375134
Haemorrhage 13.49 9.69 264 303962 54605 46327231
Cerebrovascular accident 13.45 9.69 530 303696 100509 46281327
Joint warmth 13.25 9.69 27 304199 1240 46380596
Transplant dysfunction 13.21 9.69 7 304219 4675 46377161
Pathogen resistance 13.20 9.69 12 304214 6048 46375788
Lupus-like syndrome 13.19 9.69 92 304134 7752 46374084
Oliguria 13.17 9.69 23 304203 8736 46373100
Premature baby 13.17 9.69 178 304048 17934 46363902
Genital haemorrhage 13.15 9.69 14 304212 6552 46375284
Product adhesion issue 13.13 9.69 8 304218 4947 46376889
Drug-induced liver injury 13.12 9.69 104 304122 25264 46356572
Naevus flammeus 13.12 9.69 9 304217 121 46381715
Hallucination, visual 12.99 9.69 66 304160 17807 46364029
Limb injury 12.96 9.69 186 304040 18988 46362848
Platelet count decreased 12.82 9.69 527 303699 99497 46282339
Chest pain 12.82 9.69 982 303244 175342 46206494
Feeling abnormal 12.80 9.69 675 303551 124385 46257451
Tooth disorder 12.69 9.69 218 304008 23085 46358751
Intervertebral disc degeneration 12.59 9.69 137 304089 13115 46368721
Haematotoxicity 12.57 9.69 16 304210 6917 46374919
Injection site induration 12.57 9.69 93 304133 7986 46373850
Hernia 12.56 9.69 107 304119 9588 46372248
Lymphoma 12.55 9.69 108 304118 9705 46372131
Subdural haematoma 12.55 9.69 43 304183 12954 46368882
Abortion missed 12.48 9.69 30 304196 1542 46380294
Fluid overload 12.47 9.69 115 304111 27070 46354766
Haemophagocytic lymphohistiocytosis 12.46 9.69 22 304204 8320 46373516
Dystonia 12.46 9.69 35 304191 11222 46370614
Pancreatic steatosis 12.44 9.69 23 304203 982 46380854
Panic attack 12.41 9.69 79 304147 20163 46361673
Anterior chamber cleavage syndrome 12.41 9.69 10 304216 174 46381662
Muscle spasticity 12.35 9.69 36 304190 11404 46370432
Cardiac failure acute 12.34 9.69 21 304205 8057 46373779
Placental insufficiency 12.34 9.69 27 304199 1304 46380532
Autism spectrum disorder 12.30 9.69 17 304209 565 46381271
Tubulointerstitial nephritis 12.29 9.69 52 304174 14736 46367100
Hypoglycaemia neonatal 12.29 9.69 22 304204 916 46380920
Foetal anticonvulsant syndrome 12.26 9.69 15 304211 441 46381395
Delusion 12.22 9.69 35 304191 11153 46370683
Drug abuser 12.22 9.69 3 304223 3230 46378606
Red blood cell sedimentation rate 12.15 9.69 32 304194 1741 46380095
Paralysis 12.14 9.69 24 304202 8697 46373139
Proteinuria 12.10 9.69 61 304165 16492 46365344
Failed induction of labour 12.06 9.69 13 304213 332 46381504
Cytopenia 12.05 9.69 20 304206 7748 46374088
Forceps delivery 11.99 9.69 10 304216 183 46381653
Pulmonary oedema 11.93 9.69 248 303978 50857 46330979
C-reactive protein increased 11.91 9.69 481 303745 58109 46323727
Lung neoplasm 11.91 9.69 71 304155 5669 46376167
Photophobia 11.87 9.69 146 304080 14398 46367438
Ulcer 11.87 9.69 169 304057 17223 46364613
Human anti-human antibody test 11.85 9.69 13 304213 339 46381497
Parkinsonism 11.84 9.69 21 304205 7927 46373909
Oedema peripheral 11.84 9.69 888 303338 158818 46223018
Tendon disorder 11.82 9.69 64 304162 4931 46376905
Wound infection pseudomonas 11.80 9.69 28 304198 1427 46380409
Uterine contractions during pregnancy 11.80 9.69 16 304210 522 46381314
Multiple sclerosis 11.75 9.69 104 304122 24687 46357149
Bone pain 11.71 9.69 225 304001 46665 46335171
Lymphatic fistula 11.69 9.69 21 304205 877 46380959
Haemorrhage intracranial 11.68 9.69 43 304183 12681 46369155
Crystal nephropathy 11.65 9.69 20 304206 805 46381031
Incorrect route of product administration 11.62 9.69 61 304165 16322 46365514
Haematocrit decreased 11.60 9.69 305 303921 34752 46347084
Vacuum extractor delivery 11.59 9.69 9 304217 148 46381688
Cyanosis 11.59 9.69 59 304167 15912 46365924
Catatonia 11.57 9.69 5 304221 3757 46378079
Salivary hypersecretion 11.56 9.69 15 304211 6430 46375406
Myofascial pain syndrome 11.51 9.69 33 304193 1888 46379948
Femoral hernia incarcerated 11.50 9.69 21 304205 888 46380948
Endodontic procedure 11.47 9.69 39 304187 2446 46379390
Ileus paralytic 11.43 9.69 7 304219 4316 46377520
Acute respiratory failure 11.41 9.69 128 304098 29010 46352826
Lip swelling 11.40 9.69 108 304118 25287 46356549
Aspergillus infection 11.39 9.69 17 304209 6873 46374963
Nail injury 11.35 9.69 14 304212 415 46381421
Psychomotor hyperactivity 11.31 9.69 29 304197 9584 46372252
Dysphagia 11.30 9.69 401 303825 76911 46304925
Metastases to lung 11.30 9.69 34 304192 10662 46371174
Bone contusion 11.22 9.69 20 304206 830 46381006
Inflammatory bowel disease 11.21 9.69 46 304180 3159 46378677
Atrial fibrillation 11.20 9.69 556 303670 103034 46278802
Incorrect product administration duration 11.18 9.69 29 304197 9548 46372288
Stress at work 11.18 9.69 22 304204 985 46380851
Lung neoplasm malignant 11.17 9.69 152 304074 15337 46366499
Bundle branch block right 11.16 9.69 9 304217 4810 46377026
Atrioventricular block 11.07 9.69 17 304209 6794 46375042
Myocarditis 11.03 9.69 21 304205 7718 46374118
Colitis microscopic 11.01 9.69 16 304210 6540 46375296
Irritability 11.00 9.69 128 304098 28818 46353018
Neuropathy peripheral 10.99 9.69 482 303744 90411 46291425
Anuria 10.92 9.69 38 304188 11393 46370443
Squamous cell carcinoma of skin 10.90 9.69 64 304162 5083 46376753
Nodal osteoarthritis 10.89 9.69 19 304207 775 46381061
Renal mass 10.88 9.69 31 304195 1767 46380069
Vascular rupture 10.86 9.69 25 304201 1249 46380587
Inflammatory pain 10.84 9.69 17 304209 634 46381202
Cytomegalovirus viraemia 10.83 9.69 8 304218 4470 46377366
Breast cancer metastatic 10.82 9.69 49 304177 13629 46368207
Complication of pregnancy 10.73 9.69 15 304211 504 46381332
Dysmorphism 10.70 9.69 32 304194 1875 46379961
Tonsillitis 10.69 9.69 62 304164 4902 46376934
Mood altered 10.65 9.69 46 304180 12961 46368875
Pleuritic pain 10.64 9.69 75 304151 6341 46375495
Pulseless electrical activity 10.62 9.69 19 304207 7148 46374688
Kidney infection 10.61 9.69 161 304065 16628 46365208
Dermatitis exfoliative 10.56 9.69 13 304213 5703 46376133
Crohn's disease 10.56 9.69 78 304148 6693 46375143
Creatinine renal clearance decreased 10.56 9.69 18 304208 6902 46374934
Large for dates baby 10.50 9.69 14 304212 449 46381387
Increased tendency to bruise 10.46 9.69 101 304125 9373 46372463
Abortion threatened 10.46 9.69 16 304210 584 46381252
Foetal growth restriction 10.45 9.69 76 304150 6491 46375345
Injection site discolouration 10.44 9.69 79 304147 6831 46375005
Congenital hydronephrosis 10.42 9.69 13 304213 390 46381446
Tooth abscess 10.39 9.69 127 304099 12506 46369330
Dementia 10.36 9.69 56 304170 14874 46366962
Decreased insulin requirement 10.33 9.69 8 304218 131 46381705
Mycobacterium tuberculosis complex test positive 10.33 9.69 28 304198 1550 46380286
Vascular device infection 10.31 9.69 5 304221 3512 46378324
Inflammatory marker increased 10.28 9.69 66 304160 5409 46376427
Wound infection 10.26 9.69 108 304118 10251 46371585
Wrong technique in product usage process 10.23 9.69 273 303953 54149 46327687
Skin infection 10.21 9.69 116 304110 11223 46370613
Neonatal respiratory distress syndrome 10.19 9.69 38 304188 2495 46379341
Sinus tachycardia 10.18 9.69 91 304135 21558 46360278
Morning sickness 10.18 9.69 17 304209 669 46381167
Ankylosing spondylitis 10.17 9.69 77 304149 6660 46375176
Medication error 10.14 9.69 141 304085 30770 46351066
Circulatory collapse 10.12 9.69 91 304135 21533 46360303
Bronchopulmonary aspergillosis 10.12 9.69 21 304205 7475 46374361
Arthropod bite 10.11 9.69 69 304157 5772 46376064
Skin fissures 10.07 9.69 85 304141 7595 46374241
Chondropathy 10.07 9.69 32 304194 1938 46379898
Infusion site pain 10.06 9.69 33 304193 10074 46371762
Lung adenocarcinoma 10.04 9.69 54 304172 4150 46377686
Disseminated tuberculosis 10.02 9.69 40 304186 2712 46379124
Urinary retention 10.00 9.69 115 304111 25946 46355890
Rheumatoid lung 9.99 9.69 29 304197 1671 46380165
Diabetes mellitus 9.98 9.69 249 303977 49816 46332020
Mass 9.95 9.69 118 304108 11535 46370301
Polychondritis 9.94 9.69 13 304213 409 46381427
Iodine allergy 9.93 9.69 15 304211 541 46381295
Haemoptysis 9.88 9.69 116 304110 26073 46355763
Normal newborn 9.86 9.69 70 304156 5931 46375905
Bowen's disease 9.84 9.69 10 304216 238 46381598
Catheter management 9.80 9.69 3 304223 2792 46379044
Catheter site erythema 9.78 9.69 7 304219 3976 46377860
Product complaint 9.78 9.69 43 304183 12058 46369778
Oligohydramnios 9.72 9.69 65 304161 5400 46376436
Pregnancy with contraceptive device 9.71 9.69 9 304217 4494 46377342
Bradykinesia 9.70 9.69 7 304219 3959 46377877
Cold type haemolytic anaemia 9.69 9.69 9 304217 191 46381645

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 440.65 10.00 707 130321 40490 29780960
Drug abuse 306.71 10.00 12 131016 82060 29739390
Completed suicide 220.21 10.00 80 130948 99412 29722038
Toxicity to various agents 214.02 10.00 277 130751 176906 29644544
Arthralgia 207.57 10.00 1154 129874 134637 29686813
Foetal exposure during pregnancy 205.15 10.00 480 130548 36391 29785059
Psoriatic arthropathy 117.35 10.00 231 130797 15530 29805920
Drug interaction 109.52 10.00 475 130553 199093 29622357
Joint swelling 100.85 10.00 440 130588 46506 29774944
Sickle cell anaemia with crisis 99.07 10.00 83 130945 2319 29819131
Premature baby 86.00 10.00 211 130817 16480 29804970
Exposure during pregnancy 80.45 10.00 145 130883 9116 29812334
Intentional overdose 72.40 10.00 46 130982 41435 29780015
Nasopharyngitis 69.93 10.00 469 130559 58380 29763070
Neonatal respiratory distress syndrome 69.84 10.00 87 130941 3925 29817525
Overdose 68.15 10.00 169 130859 84168 29737282
Acute kidney injury 68.04 10.00 819 130209 273023 29548427
Atrial septal defect 67.47 10.00 112 130916 6589 29814861
Tenosynovitis 67.33 10.00 80 130948 3435 29818015
Blood pressure fluctuation 64.85 10.00 196 130832 17307 29804143
Enthesopathy 63.85 10.00 71 130957 2835 29818615
Musculoskeletal stiffness 56.67 10.00 308 130720 35573 29785877
Maternal drugs affecting foetus 55.02 10.00 80 130948 4193 29817257
Drug reaction with eosinophilia and systemic symptoms 53.38 10.00 29 130999 28459 29792991
Hepatic function abnormal 53.20 10.00 63 130965 41882 29779568
Hypospadias 51.36 10.00 61 130967 2618 29818832
Death 50.45 10.00 1185 129843 356098 29465352
Synovitis 49.68 10.00 123 130905 9660 29811790
Pain 49.27 10.00 1043 129985 171598 29649852
Maternal exposure during pregnancy 46.29 10.00 70 130958 3801 29817649
Small for dates baby 45.65 10.00 63 130965 3145 29818305
Maternal exposure during breast feeding 44.99 10.00 45 130983 1587 29819863
Suicide attempt 44.55 10.00 57 130971 36640 29784810
Tongue disorder 44.54 10.00 73 130955 4249 29817201
Low birth weight baby 43.95 10.00 88 130940 5988 29815462
Ventricular septal defect 43.89 10.00 65 130963 3464 29817986
Dysmorphism 43.84 10.00 49 130979 1968 29819482
Psoriasis 43.62 10.00 327 130701 42179 29779271
Hypoglycaemia neonatal 42.45 10.00 43 130985 1540 29819910
Haemoglobin decreased 42.02 10.00 717 130311 113381 29708069
Coma 41.15 10.00 71 130957 40378 29781072
Infusion related reaction 40.46 10.00 310 130718 40254 29781196
C-reactive protein abnormal 40.45 10.00 81 130947 5512 29815938
Lower respiratory tract infection 39.97 10.00 226 130802 26488 29794962
Drug intolerance 39.68 10.00 336 130692 44955 29776495
Drug resistance 38.44 10.00 20 131008 20113 29801337
Arthropathy 38.35 10.00 186 130842 20541 29800909
Arthritis 38.21 10.00 209 130819 24192 29797258
Intentional product misuse 37.94 10.00 58 130970 34609 29786841
Febrile neutropenia 37.43 10.00 293 130735 106400 29715050
Pulmonary fibrosis 37.25 10.00 153 130875 15737 29805713
Rhabdomyolysis 36.20 10.00 149 130879 63431 29758019
Pancytopenia 35.22 10.00 545 130483 84507 29736943
Respiratory arrest 34.94 10.00 46 130982 29212 29792238
Peripheral swelling 33.70 10.00 412 130616 60662 29760788
Product use in unapproved indication 33.60 10.00 187 130841 73506 29747944
Syndactyly 33.57 10.00 27 131001 711 29820739
Cryptorchism 33.50 10.00 39 130989 1638 29819812
Basal cell carcinoma 33.26 10.00 149 130879 15919 29805531
Exposure via breast milk 32.14 10.00 37 130991 1535 29819915
Large for dates baby 31.69 10.00 28 131000 842 29820608
Delirium 31.57 10.00 83 130945 40548 29780902
Drug dependence 31.51 10.00 28 131000 21267 29800183
Skin cancer 31.24 10.00 91 130937 7870 29813580
Palmar-plantar erythrodysaesthesia syndrome 31.13 10.00 13 131015 14857 29806593
Serotonin syndrome 30.99 10.00 20 131008 17871 29803579
Cardiac arrest 30.72 10.00 259 130769 92591 29728859
Osteoarthritis 30.66 10.00 160 130868 18189 29803261
Foetal anticonvulsant syndrome 30.39 10.00 26 131002 748 29820702
Renal failure 30.29 10.00 390 130638 128576 29692874
Blood pressure systolic increased 29.70 10.00 138 130890 14972 29806478
Drug withdrawal syndrome 29.37 10.00 26 131002 19783 29801667
Bradycardia 28.94 10.00 168 130860 65358 29756092
Pain in extremity 28.87 10.00 658 130370 109563 29711887
Loss of personal independence in daily activities 28.86 10.00 177 130851 21358 29800092
Cardiac failure 28.82 10.00 230 130798 83188 29738262
Hypoglycaemia 28.69 10.00 120 130908 50861 29770589
Angioedema 28.46 10.00 68 130960 34316 29787134
Musculoskeletal pain 28.41 10.00 232 130796 30708 29790742
Alanine aminotransferase abnormal 28.02 10.00 45 130983 2574 29818876
Agitation 27.01 10.00 133 130895 53940 29767510
Blood pressure systolic abnormal 26.74 10.00 33 130995 1474 29819976
Intentional self-injury 26.50 10.00 13 131015 13519 29807931
Blood pressure increased 26.45 10.00 452 130576 71476 29749974
Knee arthroplasty 25.70 10.00 68 130960 5562 29815888
Juvenile idiopathic arthritis 25.57 10.00 27 131001 1016 29820434
Cytomegalovirus infection 25.53 10.00 40 130988 23634 29797816
Congenital hand malformation 25.45 10.00 19 131009 447 29821003
Poisoning 25.40 10.00 9 131019 11373 29810077
Rheumatoid nodule 25.27 10.00 34 130994 1656 29819794
Medical device implantation 25.25 10.00 20 131008 515 29820935
Tendonitis 25.21 10.00 85 130943 7951 29813499
Pneumonia 24.07 10.00 1734 129294 332572 29488878
Hyperglycaemia 23.64 10.00 77 130951 35123 29786327
Suicidal ideation 23.57 10.00 80 130948 36034 29785416
Caesarean section 23.25 10.00 37 130991 2100 29819350
Injection site pain 23.01 10.00 218 130810 30092 29791358
Depressed level of consciousness 22.74 10.00 88 130940 38134 29783316
Lactic acidosis 22.58 10.00 66 130962 31147 29790303
Arthritis bacterial 22.53 10.00 56 130972 4408 29817042
Shock 22.46 10.00 41 130987 22818 29798632
Agitation neonatal 22.45 10.00 25 131003 1000 29820450
Weight decreased 22.40 10.00 839 130189 150082 29671368
Selective eating disorder 22.37 10.00 32 130996 1652 29819798
Serum ferritin increased 22.16 10.00 63 130965 5374 29816076
Vitamin D deficiency 22.15 10.00 61 130967 5109 29816341
Altered state of consciousness 22.11 10.00 33 130995 19886 29801564
Back disorder 22.08 10.00 67 130961 5927 29815523
Pathogen resistance 21.82 10.00 5 131023 8405 29813045
Infection 21.34 10.00 469 130559 77605 29743845
Hand deformity 21.17 10.00 33 130995 1840 29819610
Body temperature decreased 21.10 10.00 91 130937 9564 29811886
Talipes 21.04 10.00 31 130997 1644 29819806
Multiple organ dysfunction syndrome 21.03 10.00 177 130851 63310 29758140
Cellulitis 20.99 10.00 304 130724 46480 29774970
Psychotic disorder 20.77 10.00 39 130989 21476 29799974
Post procedural infection 20.64 10.00 55 130973 4517 29816933
Prostate cancer 20.58 10.00 177 130851 23780 29797670
Foetal growth restriction 20.27 10.00 47 130981 3538 29817912
Back pain 20.27 10.00 590 130438 102006 29719444
Speech disorder developmental 19.62 10.00 25 131003 1154 29820296
Joint effusion 19.60 10.00 47 130981 3616 29817834
Haemangioma congenital 19.30 10.00 17 131011 509 29820941
Poor venous access 19.25 10.00 37 130991 2443 29819007
Off label use 19.23 10.00 893 130135 248397 29573053
Lacrimal disorder 19.18 10.00 14 131014 318 29821132
Electrocardiogram QT prolonged 19.15 10.00 86 130942 35749 29785701
Hyperbilirubinaemia neonatal 18.97 10.00 19 131009 671 29820779
Aggression 18.88 10.00 90 130938 36817 29784633
Renal impairment 18.86 10.00 257 130771 83927 29737523
Infective pulmonary exacerbation of cystic fibrosis 18.75 10.00 7 131021 8565 29812885
Immunodeficiency 18.73 10.00 51 130977 4243 29817207
Substance abuse 18.64 10.00 4 131024 7036 29814414
Patent ductus arteriosus 18.42 10.00 42 130986 3127 29818323
Wound 17.94 10.00 104 130924 12298 29809152
Influenza 17.91 10.00 278 130750 43120 29778330
Hypocalcaemia 17.90 10.00 42 130986 21334 29800116
Congenital bladder anomaly 17.89 10.00 13 131015 293 29821157
Jaundice neonatal 17.84 10.00 23 131005 1074 29820376
Bradycardia neonatal 17.79 10.00 21 131007 895 29820555
Somnolence 17.73 10.00 307 130721 96456 29724994
Agranulocytosis 17.68 10.00 44 130984 21898 29799552
Blood pressure diastolic increased 17.66 10.00 38 130990 2720 29818730
Sinusitis 17.55 10.00 223 130805 33122 29788328
Umbilical hernia 17.51 10.00 45 130983 3616 29817834
Injection site bruising 17.47 10.00 71 130957 7267 29814183
Sedation 17.33 10.00 28 131000 16345 29805105
Anal fistula 17.04 10.00 47 130981 3939 29817511
Cleft lip 16.91 10.00 13 131015 320 29821130
Rash maculo-papular 16.79 10.00 56 130972 25362 29796088
Weight decrease neonatal 16.77 10.00 13 131015 324 29821126
Hypokalaemia 16.59 10.00 140 130888 50052 29771398
Urticaria 16.43 10.00 156 130872 54450 29767000
Crohn's disease 16.37 10.00 49 130979 4303 29817147
Malignant melanoma 16.31 10.00 70 130958 7341 29814109
Ankyloglossia congenital 16.23 10.00 12 131016 278 29821172
Blood pressure diastolic decreased 16.21 10.00 62 130966 6169 29815281
Neuroleptic malignant syndrome 16.21 10.00 29 130999 16266 29805184
Foot deformity 16.18 10.00 42 130986 3395 29818055
Arthrodesis 16.18 10.00 14 131014 409 29821041
Foetal disorder 16.07 10.00 17 131011 641 29820809
Otitis media 15.98 10.00 35 130993 2536 29818914
Pyrexia 15.92 10.00 1092 129936 293397 29528053
Joint range of motion decreased 15.91 10.00 59 130969 5786 29815664
Asthma 15.83 10.00 93 130935 36081 29785369
Multiple congenital abnormalities 15.79 10.00 15 131013 496 29820954
Peripheral artery thrombosis 15.75 10.00 32 130996 2200 29819250
Renal aplasia 15.65 10.00 17 131011 661 29820789
Hypermobility syndrome 15.65 10.00 11 131017 235 29821215
Product quality issue 15.63 10.00 37 130991 18737 29802713
Haematocrit decreased 15.60 10.00 204 130824 30495 29790955
Tonsil cancer 15.57 10.00 18 131010 750 29820700
Hydrocele 15.26 10.00 30 130998 2014 29819436
Septic arthritis staphylococcal 15.25 10.00 14 131014 443 29821007
Hepatic failure 15.17 10.00 87 130941 33956 29787494
Blood creatine phosphokinase increased 15.08 10.00 121 130907 43727 29777723
Neck mass 14.97 10.00 24 131004 1371 29820079
Heart rate decreased 14.95 10.00 149 130879 20845 29800605
Kidney infection 14.87 10.00 49 130979 4529 29816921
Arthritis infective 14.82 10.00 35 130993 2667 29818783
Cytokine release syndrome 14.77 10.00 13 131015 9920 29811530
Oropharyngeal pain 14.75 10.00 190 130838 28306 29793144
Red blood cell count decreased 14.70 10.00 178 130850 26143 29795307
Contraindicated product administered 14.64 10.00 127 130901 17104 29804346
Fatigue 14.63 10.00 1609 129419 319064 29502386
Congenital anomaly 14.54 10.00 23 131005 1299 29820151
Joint stiffness 14.53 10.00 80 130948 9281 29812169
Cholestasis 14.49 10.00 58 130970 24892 29796558
Pleural fibrosis 14.35 10.00 24 131004 1420 29820030
Incorrect route of product administration 14.33 10.00 17 131011 11298 29810152
Therapeutic product effect decreased 14.27 10.00 192 130836 28884 29792566
Lung neoplasm malignant 14.17 10.00 114 130914 15018 29806432
Drug withdrawal syndrome neonatal 14.14 10.00 38 130990 3137 29818313
Hypertriglyceridaemia 14.10 10.00 9 131019 8089 29813361
Grip strength decreased 14.03 10.00 30 130998 2138 29819312
Knee deformity 13.97 10.00 12 131016 347 29821103
Vascular insufficiency 13.92 10.00 12 131016 349 29821101
Maternal exposure timing unspecified 13.83 10.00 12 131016 352 29821098
Acute hepatic failure 13.71 10.00 19 131009 11808 29809642
Emphysema 13.70 10.00 79 130949 9323 29812127
Hernia pain 13.66 10.00 10 131018 228 29821222
Hepatitis 13.60 10.00 51 130977 22305 29799145
Neurotoxicity 13.53 10.00 23 131005 13159 29808291
Venoocclusive liver disease 13.49 10.00 6 131022 6607 29814843
Tachycardia 13.49 10.00 234 130794 73505 29747945
Blood insulin increased 13.38 10.00 12 131016 368 29821082
Anal atresia 13.20 10.00 11 131017 305 29821145
Tuberculosis 13.20 10.00 70 130958 8007 29813443
Disease progression 13.19 10.00 258 130770 79616 29741834
Pulmonary tuberculosis 13.19 10.00 49 130979 4808 29816642
Hallucination 13.17 10.00 144 130884 48915 29772535
Autism spectrum disorder 13.14 10.00 22 131006 1303 29820147
Diverticular perforation 13.13 10.00 37 130991 3140 29818310
Hepatocellular injury 13.09 10.00 62 130966 25409 29796041
Anaphylactic shock 12.96 10.00 26 131002 13967 29807483
Injection site swelling 12.94 10.00 74 130954 8706 29812744
Diabetic ketoacidosis 12.92 10.00 32 130996 15954 29805496
Full blood count decreased 12.92 10.00 115 130913 15602 29805848
C-reactive protein decreased 12.81 10.00 24 131004 1554 29819896
Neonatal seizure 12.80 10.00 13 131015 467 29820983
Intellectual disability 12.75 10.00 17 131011 821 29820629
Plagiocephaly 12.67 10.00 11 131017 323 29821127
Pouchitis 12.66 10.00 15 131013 642 29820808
Palindromic rheumatism 12.65 10.00 9 131019 196 29821254
Moaning 12.55 10.00 16 131012 739 29820711
Proteinuria 12.52 10.00 33 130995 16112 29805338
Excessive cerumen production 12.48 10.00 10 131018 262 29821188
Osteonecrosis of jaw 12.31 10.00 41 130987 18577 29802873
Gangrene neonatal 12.31 10.00 9 131019 205 29821245
Mean cell volume increased 12.30 10.00 28 131000 2082 29819368
Blood pressure diastolic abnormal 12.28 10.00 21 131007 1266 29820184
Foetal heart rate deceleration abnormality 12.17 10.00 12 131016 416 29821034
Cerebral haemorrhage 12.14 10.00 89 130939 32798 29788652
Pulmonary artery stenosis congenital 12.08 10.00 13 131015 500 29820950
Developmental delay 12.03 10.00 28 131000 2113 29819337
Disseminated intravascular coagulation 11.97 10.00 53 130975 22118 29799332
Foetal distress syndrome 11.96 10.00 18 131010 973 29820477
Finger deformity 11.95 10.00 18 131010 974 29820476
Nerve compression 11.94 10.00 33 130995 2769 29818681
Respiratory failure 11.92 10.00 342 130686 100300 29721150
Congenital diaphragmatic hernia 11.87 10.00 9 131019 217 29821233
Steatorrhoea 11.80 10.00 15 131013 691 29820759
Injection site erythema 11.77 10.00 102 130926 13732 29807718
Urinary tract infection 11.76 10.00 413 130615 73246 29748204
Fistula 11.75 10.00 49 130979 5073 29816377
Drug level increased 11.74 10.00 41 130987 18313 29803137
Spinal disorder 11.69 10.00 37 130991 3348 29818102
Mouth ulceration 11.67 10.00 83 130945 10526 29810924
Status epilepticus 11.66 10.00 19 131009 11053 29810397
Skin lesion 11.64 10.00 128 130900 18366 29803084
Pyelocaliectasis 11.61 10.00 18 131010 999 29820451
Transaminases increased 11.53 10.00 58 130970 23399 29798051
Gamma-glutamyltransferase increased 11.53 10.00 78 130950 29272 29792178
Foetal hypokinesia 11.52 10.00 11 131017 366 29821084
Hypoxia 11.48 10.00 144 130884 47710 29773740
Immunosuppression 11.48 10.00 49 130979 5126 29816324
Decreased vibratory sense 11.45 10.00 11 131017 369 29821081
Vitamin B12 deficiency 11.42 10.00 31 130997 2574 29818876
Cholelithiasis 11.39 10.00 137 130891 20088 29801362
Stevens-Johnson syndrome 11.38 10.00 39 130989 17517 29803933
Anaemia vitamin B12 deficiency 11.34 10.00 10 131018 300 29821150
Therapeutic response shortened 11.22 10.00 38 130990 3562 29817888
Blood creatinine increased 11.21 10.00 309 130719 91066 29730384
Frequent bowel movements 11.21 10.00 69 130959 8336 29813114
Squamous cell carcinoma 11.16 10.00 80 130948 10170 29811280
Red blood cell sedimentation rate increased 11.09 10.00 62 130966 7233 29814217
Gastrointestinal infection 11.09 10.00 39 130989 3726 29817724
Joint instability 11.09 10.00 11 131017 384 29821066
Akathisia 11.07 10.00 6 131022 5898 29815552
Restlessness 11.04 10.00 56 130972 22543 29798907
Dermatitis psoriasiform 11.03 10.00 19 131009 1152 29820298
Hepatic encephalopathy 11.01 10.00 29 130999 14163 29807287
Blood iron increased 11.01 10.00 16 131012 838 29820612
Pulmonary toxicity 10.99 10.00 44 130984 4472 29816978
Infected bite 10.98 10.00 10 131018 313 29821137
Upper respiratory tract infection 10.95 10.00 175 130853 27301 29794149
Hepatic siderosis 10.95 10.00 8 131020 182 29821268
Progressive multifocal leukoencephalopathy 10.93 10.00 14 131014 8999 29812451
Toxic epidermal necrolysis 10.87 10.00 41 130987 17899 29803551
Appendix disorder 10.85 10.00 13 131015 563 29820887
Lung neoplasm 10.83 10.00 44 130984 4502 29816948
Drug-induced liver injury 10.80 10.00 52 130976 21222 29800228
Pancreatic duct stenosis 10.76 10.00 8 131020 187 29821263
Hyperbilirubinaemia 10.73 10.00 38 130990 16904 29804546
Congenital hydronephrosis 10.71 10.00 14 131014 663 29820787
Haemolysis 10.69 10.00 61 130967 7170 29814280
Brain oedema 10.67 10.00 24 131004 12374 29809076
Nephrolithiasis 10.64 10.00 160 130868 24650 29796800
Neck pain 10.57 10.00 139 130889 20805 29800645
Oesophageal adenocarcinoma 10.55 10.00 16 131012 871 29820579
Pancreatic calcification 10.47 10.00 8 131020 195 29821255
Spina bifida 10.47 10.00 10 131018 333 29821117
Anti-erythropoietin antibody positive 10.47 10.00 16 131012 877 29820573
Hyperosmolar state 10.44 10.00 11 131017 413 29821037
Folate deficiency 10.34 10.00 17 131011 992 29820458
Cystitis haemorrhagic 10.32 10.00 4 131024 4783 29816667
Cleft palate 10.29 10.00 13 131015 595 29820855
Arthropod bite 10.28 10.00 28 131000 2330 29819120
Retinopathy hypertensive 10.23 10.00 9 131019 269 29821181
Injection site haemorrhage 10.17 10.00 64 130964 7791 29813659
Necrotising fasciitis streptococcal 10.14 10.00 7 131021 145 29821305
Erythema multiforme 10.11 10.00 12 131016 7973 29813477
Placental insufficiency 10.09 10.00 6 131022 95 29821355
Hypotonia neonatal 10.09 10.00 17 131011 1012 29820438
Metabolic acidosis 10.04 10.00 110 130918 37351 29784099
Lung cancer metastatic 10.02 10.00 29 130999 2499 29818951

Pharmacologic Action:

SourceCodeDescription
ATC A11HA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:61115 hdac inhibitor
CHEBI has role CHEBI:62913 poly(adp-ribose) polymerase inhibitors
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:67079 antiinflammatory agents
CHEBI has role CHEBI:71181 sir2 inhibitors
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:75772 baker's yeast metabolite
CHEBI has role CHEBI:76971 e.coli metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Acne vulgaris indication 88616000
Pellagra indication 418186002 DOID:8457
Niacin deficiency indication 418279001
Methemoglobinemia off-label use 38959009 DOID:10783
Goiter contraindication 3716002 DOID:12176
Peptic ulcer contraindication 13200003 DOID:750
Hyperkalemia contraindication 14140009
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hashimoto thyroiditis contraindication 21983002
Acute tuberculosis contraindication 25629007
Bronchitis contraindication 32398004 DOID:6132
Low blood pressure contraindication 45007003
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Arterial hemorrhage contraindication 234003006
Disease of liver contraindication 235856003 DOID:409
Hypocomplementemic urticarial vasculitis contraindication 239945009
Rhabdomyolysis contraindication 240131006
Pregnancy, function contraindication 289908002
Acute coronary syndrome contraindication 394659003
Hemochromatosis contraindication 399187006 DOID:2352

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.95 acidic
pKa2 3.41 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
NAD-dependent deacetylase sirtuin 3 Enzyme IC50 4.85 CHEMBL
NAD-dependent protein deacetylase sirtuin-2 Enzyme IC50 5.92 CHEMBL
NAD-dependent protein deacylase sirtuin-5, mitochondrial Enzyme IC50 4.33 CHEMBL
NAD-dependent protein deacetylase sirtuin-1 Enzyme IC50 4.30 CHEMBL
Hydroxycarboxylic acid receptor 2 GPCR WOMBAT-PK
Hydroxycarboxylic acid receptor 3 GPCR WOMBAT-PK
Nicotinate-nucleotide pyrophosphorylase [carboxylating] Enzyme WOMBAT-PK
Nicotinamide N-methyltransferase Enzyme WOMBAT-PK
Fatty-acid amide hydrolase 1 Enzyme IC50 5.48 CHEMBL
NAD-dependent deacetylase HST2 Enzyme IC50 4.04 CHEMBL
Putative silent information regulator 2 Unclassified IC50 4.40 CHEMBL

External reference:

IDSource
4020285 VUID
N0000148162 NUI
D00036 KEGG_DRUG
4017632 VANDF
4017718 VANDF
4020285 VANDF
C0028027 UMLSCUI
CHEBI:17154 CHEBI
NCA PDB_CHEM_ID
936 PUBCHEM_CID
DB02701 DRUGBANK_ID
CHEMBL1140 ChEMBL_ID
D009536 MESH_DESCRIPTOR_UI
404 INN_ID
25X51I8RD4 UNII
7405 RXNORM
4947 MMSL
5170 MMSL
5684 MMSL
72420 MMSL
d03739 MMSL
001055 NDDF
173196005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 20 mg ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 20 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 20 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 20 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 20 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 20 mg ORAL Unapproved drug other 11 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 15 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 15 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 25 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 15 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 20 mg ORAL UNULLPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 100 mg ORAL UNULLPPROVED DRUG OTHER 10 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
PRENULLTAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 20 mg ORAL unapproved drug other 8 sections
PRENULLTAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 20 mg ORAL UNULLPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 15 mg ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 15 mg ORAL unapproved drug other 16 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 30 ug ORAL unapproved drug other 19 sections
PRENULLTAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 15338-522 TABLET, FILM COATED 20 mg ORAL unapproved drug other 8 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 0.80 mg ORAL UNULLPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 2 mg ORAL UNULLPPROVED DRUG OTHER 11 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 4 mg ORAL UNULLPPROVED DRUG OTHER 11 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-103 TABLET, CHEWABLE 5 mg ORAL UNULLPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-104 TABLET, CHEWABLE 5 mg ORAL UNULLPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-105 TABLET, CHEWABLE 5 mg ORAL UNULLPPROVED DRUG OTHER 12 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 17856-0010 TABLET, COATED 20 mg ORAL Unapproved drug other 8 sections