ciclosporin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
760 59865-13-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ciclosporin
  • cyclosporine
  • cyclosporin
  • ciclosporine
  • cyclosporin A
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
  • Molecular weight: 1202.64
  • Formula: C62H111N11O12
  • CLOGP: 14.36
  • LIPINSKI: 3
  • HAC: 23
  • HDO: 5
  • TPSA: 278.80
  • ALOGS: -5.10
  • ROTB: 15

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.25 g O
0.25 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.66 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 30 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.07 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 14, 1983 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 2533.84 26.48 521 9099 2192 2346273
Drug ineffective 1861.06 26.48 964 8656 100660 2247805
Transplant rejection 1711.92 26.48 329 9291 877 2347588
Product use in unapproved indication 1626.90 26.48 482 9138 10718 2337747
Pyrexia 1605.83 26.48 716 8904 52992 2295473
Transplant dysfunction 1529.59 26.48 255 9365 165 2348300
Renal impairment 1472.25 26.48 436 9184 9656 2338809
Blood creatinine increased 1393.26 26.48 422 9198 10111 2338354
Graft versus host disease 1251.56 26.48 244 9376 715 2347750
Acute graft versus host disease 1053.10 26.48 196 9424 406 2348059
Posterior reversible encephalopathy syndrome 953.46 26.48 231 9389 2249 2346216
Multiple organ dysfunction syndrome 931.51 26.48 288 9332 7353 2341112
Sepsis 922.07 26.48 357 9263 18131 2330334
Ovarian cyst 910.22 26.48 213 9407 1760 2346705
Kidney transplant rejection 889.74 26.48 175 9445 542 2347923
Hypertension 864.09 26.48 381 9239 26980 2321485
Acne 823.92 26.48 216 9404 2960 2345505
Epstein-Barr virus infection 802.03 26.48 173 9447 938 2347527
Rheumatoid arthritis 798.37 26.48 325 9295 18815 2329650
Chronic graft versus host disease 757.91 26.48 139 9481 254 2348211
Acute graft versus host disease in skin 753.06 26.48 139 9481 268 2348197
Drug intolerance 751.75 26.48 284 9336 13433 2335032
Nephropathy toxic 713.03 26.48 159 9461 1029 2347436
Pneumonia 691.83 26.48 396 9224 48900 2299565
Condition aggravated 676.85 26.48 338 9282 31641 2316824
Blood iron abnormal 656.40 26.48 109 9511 65 2348400
Graft versus host disease in gastrointestinal tract 640.35 26.48 114 9506 159 2348306
Acute kidney injury 638.76 26.48 312 9308 27810 2320655
Thrombotic microangiopathy 634.55 26.48 148 9472 1199 2347266
Graft versus host disease in skin 632.50 26.48 113 9507 163 2348302
Haemophagocytic lymphohistiocytosis 630.66 26.48 148 9472 1235 2347230
Renal failure 596.59 26.48 257 9363 17092 2331373
Alopecia 593.79 26.48 275 9345 21726 2326739
Immunosuppressant drug level increased 593.49 26.48 115 9505 320 2348145
Pancytopenia 565.61 26.48 220 9400 11232 2337233
Adenovirus infection 533.81 26.48 101 9519 236 2348229
Post transplant lymphoproliferative disorder 512.60 26.48 105 9515 420 2348045
Bronchopulmonary aspergillosis 502.96 26.48 116 9504 888 2347577
Aspergillus infection 475.66 26.48 110 9510 853 2347612
Treatment failure 469.90 26.48 170 9450 7069 2341396
Product use issue 463.48 26.48 194 9426 11975 2336490
Thrombocytopenia 459.99 26.48 221 9399 18910 2329555
Respiratory failure 456.76 26.48 198 9422 13330 2335135
Acute graft versus host disease in intestine 449.43 26.48 83 9537 160 2348305
Cystitis haemorrhagic 436.10 26.48 95 9525 541 2347924
Off label use 426.32 26.48 342 9278 73256 2275209
Septic shock 421.95 26.48 156 9464 6898 2341567
Diarrhoea 414.78 26.48 355 9265 83209 2265256
Liver function test abnormal 405.59 26.48 154 9466 7336 2341129
Dyspnoea 397.77 26.48 338 9282 78395 2270070
Anaemia 391.32 26.48 243 9377 34549 2313916
Diabetes mellitus 387.51 26.48 149 9471 7346 2341119
Seizure 386.33 26.48 213 9407 24253 2324212
BK virus infection 381.24 26.48 75 9545 231 2348234
Pseudomonas infection 378.81 26.48 95 9525 1071 2347394
Proteinuria 378.67 26.48 115 9505 2735 2345730
Sleep disorder due to general medical condition, insomnia type 372.32 26.48 76 9544 297 2348168
Cytomegalovirus viraemia 371.21 26.48 79 9541 395 2348070
Blood bilirubin increased 359.75 26.48 129 9491 5216 2343249
Psoriasis 356.37 26.48 179 9441 16829 2331636
Maternal exposure during pregnancy 348.79 26.48 169 9451 14694 2333771
Drug interaction 346.35 26.48 211 9409 28952 2319513
Complications of transplanted kidney 341.21 26.48 70 9550 282 2348183
Interstitial lung disease 332.66 26.48 135 9485 7677 2340788
Urinary tract infection 315.98 26.48 201 9419 29741 2318724
C-reactive protein increased 307.76 26.48 120 9500 6135 2342330
Vomiting 306.23 26.48 280 9340 71322 2277143
Blood lactate dehydrogenase increased 303.60 26.48 102 9518 3382 2345083
Exposure during pregnancy 303.23 26.48 184 9436 25035 2323430
Toxicity to various agents 301.90 26.48 202 9418 32552 2315913
Leukopenia 301.20 26.48 136 9484 10060 2338405
Platelet count decreased 298.00 26.48 155 9465 15658 2332807
Disease recurrence 296.63 26.48 100 9520 3351 2345114
Abdominal pain 295.41 26.48 203 9417 34171 2314294
Liver transplant rejection 294.69 26.48 62 9558 290 2348175
Erythema 290.79 26.48 179 9441 24980 2323485
Headache 284.83 26.48 283 9337 79896 2268569
Cytomegalovirus test positive 284.66 26.48 62 9558 352 2348113
Acute graft versus host disease in liver 283.92 26.48 51 9569 77 2348388
Epstein-Barr virus associated lymphoproliferative disorder 283.41 26.48 58 9562 230 2348235
Neutropenia 281.79 26.48 166 9454 21382 2327083
Infection 278.89 26.48 155 9465 17874 2330591
Neurotoxicity 278.83 26.48 85 9535 2045 2346420
Herpes zoster 272.34 26.48 125 9495 9600 2338865
Alanine aminotransferase increased 271.40 26.48 140 9480 13892 2334573
Hepatic function abnormal 261.75 26.48 106 9514 5986 2342479
Blood urea increased 261.41 26.48 92 9528 3513 2344952
Therapeutic response decreased 257.90 26.48 110 9510 7085 2341380
Staphylococcal infection 257.80 26.48 101 9519 5225 2343240
Lymphadenopathy 254.66 26.48 102 9518 5596 2342869
Nausea 254.64 26.48 313 9307 111876 2236589
Chronic allograft nephropathy 240.53 26.48 45 9575 96 2348369
Obliterative bronchiolitis 238.28 26.48 49 9571 200 2348265
Human herpesvirus 6 infection 234.05 26.48 52 9568 328 2348137
Drug level increased 232.55 26.48 79 9541 2708 2345757
Haemoglobin decreased 229.79 26.48 137 9483 18014 2330451
Febrile neutropenia 229.06 26.48 115 9505 10767 2337698
Squamous cell carcinoma 228.09 26.48 66 9554 1317 2347148
Nephrotic syndrome 227.74 26.48 63 9557 1061 2347404
Rash 227.48 26.48 219 9401 59339 2289126
Blood pressure increased 224.94 26.48 132 9488 16854 2331611
Disease progression 221.53 26.48 131 9489 16964 2331501
Bone marrow failure 220.65 26.48 92 9528 5594 2342871
Complications of bone marrow transplant 219.71 26.48 37 9583 27 2348438
Aplastic anaemia 217.41 26.48 58 9562 846 2347619
Pneumocystis jirovecii pneumonia 215.74 26.48 71 9549 2202 2346263
Pruritus 215.66 26.48 185 9435 43155 2305310
Contraindicated product administered 214.83 26.48 76 9544 2945 2345520
Lung transplant rejection 213.58 26.48 40 9580 86 2348379
Skin lesion 211.35 26.48 81 9539 3944 2344521
Hepatic failure 210.55 26.48 89 9531 5600 2342865
Venoocclusive liver disease 209.74 26.48 52 9568 556 2347909
Mucormycosis 208.00 26.48 48 9572 367 2348098
Chronic kidney disease 205.99 26.48 80 9540 4038 2344427
Demyelination 203.14 26.48 56 9564 930 2347535
Loss of personal independence in daily activities 202.94 26.48 85 9535 5226 2343239
Elbow deformity 198.52 26.48 35 9585 44 2348421
Fatigue 197.25 26.48 240 9380 84633 2263832
Weight decreased 196.26 26.48 147 9473 28224 2320241
Focal segmental glomerulosclerosis 196.12 26.48 42 9578 217 2348248
Lung infiltration 196.05 26.48 66 9554 2198 2346267
Aspartate aminotransferase increased 193.69 26.48 108 9512 12504 2335961
Haematuria 191.86 26.48 77 9543 4241 2344224
Pleural effusion 190.40 26.48 104 9516 11564 2336901
Pain 189.54 26.48 202 9418 61655 2286810
Oedema 189.13 26.48 99 9521 10104 2338361
Blood alkaline phosphatase increased 189.02 26.48 86 9534 6459 2342006
Premature labour 188.73 26.48 63 9557 2043 2346422
SLE arthritis 188.59 26.48 34 9586 53 2348412
Lymphocele 188.28 26.48 38 9582 138 2348327
Mucosal inflammation 187.58 26.48 80 9540 5144 2343321
Malaise 187.26 26.48 191 9429 55394 2293071
Inflammation 186.91 26.48 84 9536 6129 2342336
Chronic graft versus host disease in skin 185.66 26.48 33 9587 45 2348420
Venoocclusive disease 183.47 26.48 40 9580 228 2348237
Drug resistance 182.72 26.48 65 9555 2559 2345906
Heart transplant rejection 182.53 26.48 34 9586 70 2348395
Dilatation intrahepatic duct acquired 181.68 26.48 33 9587 55 2348410
Disseminated intravascular coagulation 181.55 26.48 69 9551 3281 2345184
Acute respiratory distress syndrome 179.11 26.48 68 9552 3224 2345241
Drug hypersensitivity 178.77 26.48 172 9448 46471 2301994
Renal disorder 178.76 26.48 74 9546 4414 2344051
Cough 176.16 26.48 147 9473 32970 2315495
Escherichia urinary tract infection 175.54 26.48 53 9567 1231 2347234
Immunosuppressant drug level decreased 175.42 26.48 36 9584 145 2348320
Lymphoproliferative disorder 174.74 26.48 45 9575 567 2347898
Epstein-Barr viraemia 174.19 26.48 34 9586 99 2348366
Escherichia infection 172.99 26.48 53 9567 1295 2347170
Impaired gastric emptying 172.91 26.48 49 9571 904 2347561
C-reactive protein abnormal 172.11 26.48 47 9573 752 2347713
Basal cell carcinoma 169.97 26.48 62 9558 2625 2345840
Kaposi's sarcoma 169.63 26.48 38 9582 250 2348215
Renal tubular necrosis 168.47 26.48 54 9566 1536 2346929
Psoriatic arthropathy 167.69 26.48 68 9552 3846 2344619
Encephalopathy 167.57 26.48 71 9549 4490 2343975
Normal newborn 166.35 26.48 51 9569 1249 2347216
Haemodialysis 166.13 26.48 57 9563 2012 2346453
Therapy non-responder 165.65 26.48 84 9536 8020 2340445
Caesarean section 161.55 26.48 67 9553 4014 2344451
Cholestasis 160.62 26.48 65 9555 3656 2344809
Gingival hypertrophy 160.05 26.48 38 9582 333 2348132
Haemolytic anaemia 159.56 26.48 54 9566 1827 2346638
Premature baby 159.35 26.48 62 9558 3142 2345323
Leukaemia recurrent 158.02 26.48 35 9585 217 2348248
Klebsiella infection 157.27 26.48 44 9576 773 2347692
Pneumonia cytomegaloviral 156.94 26.48 36 9584 267 2348198
Graft versus host disease in liver 156.76 26.48 28 9592 40 2348425
Ascites 156.46 26.48 72 9548 5548 2342917
Chest pain 156.04 26.48 128 9492 28009 2320456
Pneumomediastinum 154.74 26.48 34 9586 202 2348263
Hepatotoxicity 154.37 26.48 62 9558 3419 2345046
Liver disorder 153.42 26.48 74 9546 6340 2342125
Diffuse large B-cell lymphoma 150.04 26.48 43 9577 827 2347638
Lung disorder 149.58 26.48 72 9548 6140 2342325
Anuria 149.37 26.48 51 9569 1773 2346692
Oedema peripheral 148.57 26.48 116 9504 23647 2324818
Hypogammaglobulinaemia 147.69 26.48 41 9579 699 2347766
Low birth weight baby 147.58 26.48 42 9578 787 2347678
Oliguria 147.53 26.48 47 9573 1310 2347155
Alveolar proteinosis 145.70 26.48 28 9592 73 2348392
Hepatic enzyme increased 145.18 26.48 82 9538 9720 2338745
Hypoxia 143.38 26.48 70 9550 6157 2342308
Therapeutic product effect incomplete 142.34 26.48 83 9537 10448 2338017
Oral administration complication 141.80 26.48 26 9594 47 2348418
Transplant failure 141.66 26.48 33 9587 264 2348201
Skin plaque 141.53 26.48 45 9575 1246 2347219
Depressed level of consciousness 141.49 26.48 74 9546 7530 2340935
Arthralgia 141.46 26.48 163 9457 54122 2294343
Candida infection 140.77 26.48 55 9565 2818 2345647
Cytomegalovirus colitis 140.57 26.48 33 9587 274 2348191
Pericardial effusion 139.30 26.48 60 9560 3949 2344516
Skin ulcer 138.58 26.48 60 9560 3999 2344466
Myalgia 137.47 26.48 110 9510 23223 2325242
Fungal infection 137.22 26.48 63 9557 4826 2343639
Kidney fibrosis 136.58 26.48 31 9589 218 2348247
Haemolytic uraemic syndrome 136.36 26.48 37 9583 577 2347888
Decreased appetite 134.73 26.48 119 9501 28772 2319693
Generalised tonic-clonic seizure 134.61 26.48 64 9556 5308 2343157
General physical health deterioration 134.24 26.48 89 9531 14050 2334415
Device related infection 134.05 26.48 55 9565 3204 2345261
Pyelonephritis 133.91 26.48 49 9571 2092 2346373
Enterococcal infection 133.47 26.48 38 9582 713 2347752
Scedosporium infection 130.98 26.48 25 9595 62 2348403
Bacterial sepsis 130.19 26.48 34 9586 454 2348011
Splenomegaly 129.48 26.48 44 9576 1507 2346958
Neck pain 129.37 26.48 70 9550 7627 2340838
Hypertrichosis 128.51 26.48 29 9591 198 2348267
Transaminases increased 128.40 26.48 59 9561 4528 2343937
Rhabdomyolysis 126.89 26.48 66 9554 6638 2341827
Tachycardia 126.82 26.48 91 9529 16318 2332147
Hepatosplenic T-cell lymphoma 126.74 26.48 23 9597 38 2348427
Viraemia 126.04 26.48 26 9594 108 2348357
Hirsutism 125.93 26.48 30 9590 267 2348198
Still's disease 125.65 26.48 26 9594 110 2348355
Confusional state 123.02 26.48 105 9515 24239 2324226
Arthritis 122.77 26.48 74 9546 9894 2338571
Joint swelling 122.54 26.48 90 9530 16729 2331736
Leukoencephalopathy 121.96 26.48 36 9584 771 2347694
Peritonitis 121.61 26.48 48 9572 2526 2345939
Urticaria 121.29 26.48 104 9516 24157 2324308
Visual acuity reduced 120.29 26.48 59 9561 5239 2343226
Chronic graft versus host disease in liver 119.09 26.48 20 9600 14 2348451
Nephrectomy 118.94 26.48 25 9595 116 2348349
Pain in extremity 117.96 26.48 132 9488 42408 2306057
Cardiac failure 116.90 26.48 77 9543 12017 2336448
Autoimmune haemolytic anaemia 116.44 26.48 34 9586 700 2347765
Serum ferritin increased 115.93 26.48 35 9585 812 2347653
Stomatitis 114.23 26.48 70 9550 9640 2338825
Hepatitis 113.13 26.48 60 9560 6277 2342188
Respiratory distress 113.12 26.48 56 9564 5073 2343392
Renal transplant failure 113.00 26.48 23 9597 88 2348377
Encephalitis viral 112.96 26.48 26 9594 196 2348269
Musculoskeletal pain 112.14 26.48 72 9548 10758 2337707
Groin pain 111.52 26.48 38 9582 1312 2347153
Hypoproteinaemia 109.28 26.48 28 9592 345 2348120
Osteoporosis 108.79 26.48 52 9568 4362 2344103
Gastrointestinal haemorrhage 107.79 26.48 74 9546 12361 2336104
Viral haemorrhagic cystitis 107.61 26.48 21 9599 61 2348404
Bronchiectasis 107.41 26.48 34 9586 927 2347538
Acute lymphocytic leukaemia recurrent 107.09 26.48 25 9595 202 2348263
Pneumothorax 105.33 26.48 42 9578 2270 2346195
Therapeutic product effect decreased 105.01 26.48 69 9551 10720 2337745
Cushingoid 104.51 26.48 30 9590 580 2347885
Therapeutic product effect variable 104.05 26.48 23 9597 141 2348324
Staphylococcal sepsis 103.97 26.48 34 9586 1031 2347434
Gastroenteritis 103.68 26.48 45 9575 3015 2345450
Jaundice 103.57 26.48 54 9566 5454 2343011
Death 103.50 26.48 173 9447 81295 2267170
Bacterial infection 103.46 26.48 41 9579 2180 2346285
Urine output decreased 103.35 26.48 37 9583 1482 2346983
Foetal exposure during pregnancy 103.10 26.48 53 9567 5199 2343266
Gamma-glutamyltransferase increased 103.08 26.48 54 9566 5508 2342957
Epicondylitis 102.50 26.48 25 9595 248 2348217
Pain in jaw 101.66 26.48 56 9564 6316 2342149
Systemic mycosis 101.55 26.48 22 9598 121 2348344
Chronic spontaneous urticaria 101.27 26.48 20 9600 63 2348402
Agranulocytosis 101.25 26.48 46 9574 3436 2345029
Pneumatosis intestinalis 101.03 26.48 27 9593 396 2348069
Thrombotic thrombocytopenic purpura 100.74 26.48 31 9589 768 2347697
Epstein-Barr virus associated lymphoma 100.46 26.48 19 9601 44 2348421
Tremor 100.05 26.48 87 9533 20574 2327891
Herpes simplex 99.89 26.48 33 9587 1034 2347431
Encephalitis 99.61 26.48 34 9586 1180 2347285
Myocarditis 99.36 26.48 34 9586 1189 2347276
Pulmonary haemorrhage 99.31 26.48 34 9586 1191 2347274
Pneumonia bacterial 98.82 26.48 32 9588 940 2347525
Red blood cell schistocytes present 98.78 26.48 20 9600 74 2348391
Respiratory disorder 98.15 26.48 47 9573 3957 2344508
Aphasia 97.51 26.48 50 9570 4878 2343587
Systemic candida 97.42 26.48 25 9595 310 2348155
Gait disturbance 97.40 26.48 89 9531 22456 2326009
Skin mass 96.55 26.48 32 9588 1013 2347452
Nocardiosis 96.31 26.48 24 9596 262 2348203
Pre-eclampsia 96.20 26.48 35 9585 1469 2346996
Acute myeloid leukaemia 95.58 26.48 41 9579 2669 2345796
Chills 95.13 26.48 75 9545 15477 2332988
Cerebral haemorrhage 95.10 26.48 51 9569 5453 2343012
Bacteraemia 95.02 26.48 36 9584 1694 2346771
Skin necrosis 94.06 26.48 32 9588 1099 2347366
Hypotension 93.90 26.48 103 9517 32333 2316132
Disseminated tuberculosis 93.58 26.48 27 9593 532 2347933
Cutaneous T-cell lymphoma 93.49 26.48 24 9596 298 2348167
Progressive multifocal leukoencephalopathy 93.24 26.48 38 9582 2174 2346291
Asthenia 93.18 26.48 123 9497 46803 2301662
Haemolysis 92.19 26.48 31 9589 1027 2347438
Synovitis 92.07 26.48 40 9580 2686 2345779
Mechanical ventilation 91.50 26.48 24 9596 326 2348139
Renal tubular atrophy 91.33 26.48 19 9601 83 2348382
Hypersensitivity 90.14 26.48 87 9533 23506 2324959
Foetal growth restriction 89.92 26.48 31 9589 1109 2347356
Hepatitis C 89.74 26.48 33 9587 1428 2347037
Tubulointerstitial nephritis 89.67 26.48 38 9582 2400 2346065
Pustular psoriasis 89.45 26.48 29 9591 855 2347610
Pancreatitis 89.32 26.48 56 9564 8023 2340442
Electrolyte imbalance 89.32 26.48 36 9584 2001 2346464
Shock 89.12 26.48 44 9576 3960 2344505
Pneumonitis 88.76 26.48 44 9576 3995 2344470
Hepatosplenomegaly 88.66 26.48 25 9595 452 2348013
Myelodysplastic syndrome 87.88 26.48 38 9582 2522 2345943
Red blood cell sedimentation rate increased 87.65 26.48 36 9584 2101 2346364
Aplasia pure red cell 87.47 26.48 27 9593 676 2347789
Pulmonary embolism 87.24 26.48 76 9544 18007 2330458
Dialysis 87.16 26.48 36 9584 2131 2346334
Neoplasm recurrence 86.89 26.48 24 9596 401 2348064
Gastrointestinal disorder 86.69 26.48 57 9563 8860 2339605
Hair follicle tumour benign 85.91 26.48 15 9605 17 2348448
Stem cell transplant 84.73 26.48 23 9597 359 2348106
Altered state of consciousness 84.67 26.48 42 9578 3818 2344647
Renal transplant 83.93 26.48 22 9598 298 2348167
Generalised oedema 83.57 26.48 36 9584 2367 2346098
Pulmonary fibrosis 83.52 26.48 37 9583 2603 2345862
White blood cell count increased 83.16 26.48 51 9569 7027 2341438
Blood albumin decreased 83.13 26.48 33 9587 1762 2346703
Epilepsy 83.00 26.48 44 9576 4595 2343870
Premature delivery 82.83 26.48 39 9581 3161 2345304
Drug level decreased 82.82 26.48 28 9592 943 2347522
Angioedema 82.43 26.48 54 9566 8342 2340123
Pulmonary alveolar haemorrhage 82.33 26.48 26 9594 703 2347762
Cerebral infarction 81.98 26.48 43 9577 4394 2344071
Glomerular filtration rate decreased 81.75 26.48 31 9589 1462 2347003
Herpes virus infection 81.63 26.48 27 9593 849 2347616
Muscular weakness 80.85 26.48 67 9553 14830 2333635
White blood cell count decreased 80.82 26.48 73 9547 18135 2330330
Cellulitis 80.29 26.48 55 9565 9146 2339319
Blister 80.09 26.48 49 9571 6722 2341743
Hemiparesis 80.03 26.48 39 9581 3411 2345054
Muscle fatigue 79.96 26.48 22 9598 362 2348103
Graft versus host disease in lung 79.84 26.48 15 9605 33 2348432
Large intestine perforation 79.34 26.48 29 9591 1233 2347232
Endotracheal intubation 79.34 26.48 23 9597 461 2348004
Osteonecrosis 78.93 26.48 50 9570 7292 2341173
Fungaemia 78.61 26.48 20 9600 239 2348226
Surgery 78.40 26.48 45 9575 5490 2342975
Ulcer 78.22 26.48 32 9588 1848 2346617
Smooth muscle cell neoplasm 77.57 26.48 14 9606 22 2348443
Dermatitis 77.37 26.48 34 9586 2346 2346119
Myopathy 77.20 26.48 30 9590 1513 2346952
Hyperbilirubinaemia 77.08 26.48 30 9590 1519 2346946
Squamous cell carcinoma of skin 76.82 26.48 25 9595 746 2347719
Rash pustular 76.75 26.48 30 9590 1537 2346928
Enthesopathy 76.71 26.48 18 9602 149 2348316
Pulmonary oedema 76.31 26.48 49 9571 7314 2341151
Influenza 75.95 26.48 61 9559 12917 2335548
Bone erosion 75.79 26.48 23 9597 543 2347922
Oesophageal candidiasis 75.68 26.48 24 9596 658 2347807
Acinetobacter infection 75.07 26.48 18 9602 165 2348300
Necrosis 74.19 26.48 26 9594 977 2347488
Staphylococcal bacteraemia 74.13 26.48 23 9597 586 2347879
Haemodynamic instability 73.78 26.48 27 9593 1152 2347313
Graft complication 73.77 26.48 15 9605 57 2348408
Dehydration 73.68 26.48 76 9544 22219 2326246
Pulmonary tuberculosis 73.44 26.48 25 9595 860 2347605
Upper limb fracture 72.99 26.48 34 9586 2689 2345776
Lung consolidation 72.95 26.48 22 9598 508 2347957
Glomerulonephritis membranous 72.85 26.48 17 9603 137 2348328
Hepatomegaly 72.58 26.48 30 9590 1779 2346686
Immunosuppression 72.57 26.48 26 9594 1043 2347422
Dysphagia 72.42 26.48 59 9561 12746 2335719
Varicella zoster virus infection 72.19 26.48 20 9600 338 2348127
Hepatic cirrhosis 71.31 26.48 32 9588 2321 2346144
Idiopathic pneumonia syndrome 71.07 26.48 13 9607 23 2348442
Bronchitis 70.93 26.48 60 9560 13654 2334811
Leukocytosis 69.92 26.48 36 9584 3540 2344925
Life support 69.16 26.48 15 9605 83 2348382
Haematocrit decreased 69.00 26.48 38 9582 4280 2344185
Left ventricular dysfunction 68.81 26.48 26 9594 1214 2347251
Systemic inflammatory response syndrome 68.50 26.48 23 9597 758 2347707
Visual impairment 68.25 26.48 55 9565 11700 2336765
Skin toxicity 68.24 26.48 23 9597 767 2347698
Papilloedema 67.76 26.48 23 9597 784 2347681
Pulmonary mass 67.45 26.48 29 9591 1897 2346568
Clubbing 67.32 26.48 14 9606 61 2348404
Pyelonephritis acute 67.24 26.48 21 9599 547 2347918
Ankylosing spondylitis 66.99 26.48 22 9598 676 2347789
Mouth ulceration 66.87 26.48 36 9584 3876 2344589
End stage renal disease 66.77 26.48 20 9600 451 2348014
Urosepsis 66.67 26.48 29 9591 1952 2346513
Tachypnoea 66.55 26.48 30 9590 2199 2346266
Hyponatraemia 66.26 26.48 57 9563 13268 2335197
Brain oedema 65.52 26.48 30 9590 2280 2346185
Haptoglobin decreased 65.29 26.48 15 9605 112 2348353
Colitis 64.83 26.48 39 9581 5187 2343278
Toxoplasmosis 64.77 26.48 16 9604 168 2348297
Atrial fibrillation 64.65 26.48 57 9563 13711 2334754
Gouty tophus 64.31 26.48 12 9608 25 2348440
Panniculitis 64.25 26.48 20 9600 515 2347950
Overdose 64.22 26.48 67 9553 19840 2328625
Polyomavirus-associated nephropathy 64.18 26.48 16 9604 175 2348290
Photosensitivity reaction 64.11 26.48 30 9590 2397 2346068
Tuberculosis 64.06 26.48 28 9592 1907 2346558
Loss of consciousness 63.86 26.48 65 9555 18702 2329763
Rales 63.75 26.48 24 9596 1109 2347356
Microangiopathy 63.68 26.48 16 9604 181 2348284
Viral infection 63.51 26.48 37 9583 4639 2343826
Lower respiratory tract infection 63.49 26.48 39 9581 5385 2343080
Respiratory tract infection 63.12 26.48 35 9585 3994 2344471
Hyperkalaemia 63.00 26.48 40 9580 5853 2342612
Weight increased 62.97 26.48 70 9550 22267 2326198
Pathogen resistance 62.92 26.48 22 9598 821 2347644
Blood creatine phosphokinase increased 62.87 26.48 38 9582 5098 2343367
Nervous system disorder 62.75 26.48 32 9588 3084 2345381
JC virus infection 62.59 26.48 16 9604 195 2348270
Disorientation 62.58 26.48 41 9579 6331 2342134
Hypoalbuminaemia 62.37 26.48 25 9595 1369 2347096
Viral test positive 61.21 26.48 13 9607 64 2348401
Hydronephrosis 61.14 26.48 24 9596 1243 2347222
Laryngitis fungal 60.67 26.48 11 9609 18 2348447
Fibroadenoma of breast 60.65 26.48 14 9606 107 2348358
Cushing's syndrome 60.46 26.48 21 9599 768 2347697
Lymphocyte count decreased 60.44 26.48 32 9588 3331 2345134
Granuloma skin 60.42 26.48 14 9606 109 2348356
Red blood cell sedimentation rate 60.30 26.48 11 9609 19 2348446
Nonalcoholic fatty liver disease 59.79 26.48 12 9608 42 2348423
Escherichia sepsis 58.96 26.48 19 9601 549 2347916
Brain abscess 58.96 26.48 17 9603 334 2348131
Central nervous system lesion 58.78 26.48 27 9593 2067 2346398
Skin exfoliation 58.68 26.48 38 9582 5752 2342713
Abdominal discomfort 58.55 26.48 60 9560 17396 2331069
Fusarium infection 58.49 26.48 13 9607 82 2348383
Fungal endocarditis 58.30 26.48 11 9609 25 2348440
Back pain 58.20 26.48 80 9540 31579 2316886
Skin disorder 58.14 26.48 32 9588 3599 2344866
Acute myeloid leukaemia recurrent 57.93 26.48 15 9605 193 2348272
Glucose tolerance impaired 57.72 26.48 19 9601 588 2347877
Capillary leak syndrome 57.67 26.48 17 9603 362 2348103
Anaphylactic reaction 57.59 26.48 46 9574 9659 2338806
Status epilepticus 57.43 26.48 28 9592 2450 2346015
Oral candidiasis 57.24 26.48 26 9594 1939 2346526
Blood sodium decreased 57.14 26.48 30 9590 3070 2345395
Blood stem cell transplant failure 56.96 26.48 10 9610 12 2348453
Cytomegalovirus enterocolitis 56.95 26.48 13 9607 94 2348371
Hilar lymphadenopathy 56.93 26.48 14 9606 144 2348321
Nephroureterectomy 56.55 26.48 9 9611 2 2348463
Adrenal suppression 56.25 26.48 14 9606 152 2348313
Coma 56.04 26.48 44 9576 9012 2339453
Toxic encephalopathy 55.92 26.48 20 9600 798 2347667
Stenotrophomonas infection 55.83 26.48 14 9606 157 2348308
Diffuse alveolar damage 55.67 26.48 14 9606 159 2348306
Blindness 55.51 26.48 31 9589 3587 2344878
Hepatitis B 55.40 26.48 20 9600 820 2347645
Dermatomyositis 55.28 26.48 17 9603 420 2348045
Microsporidia infection 55.14 26.48 11 9609 37 2348428
Metabolic acidosis 55.04 26.48 37 9583 5961 2342504
Acute respiratory failure 54.86 26.48 29 9591 3009 2345456
Complications of transplanted lung 54.69 26.48 11 9609 39 2348426
Cholangitis 54.58 26.48 20 9600 856 2347609
Cystitis viral 54.56 26.48 10 9610 18 2348447
Pneumonia aspiration 54.53 26.48 31 9589 3711 2344754
Globulins decreased 54.26 26.48 11 9609 41 2348424
Breast cancer 54.21 26.48 44 9576 9451 2339014
Opportunistic infection 54.10 26.48 17 9603 452 2348013
Rectal cancer metastatic 53.85 26.48 11 9609 43 2348422
Non-Hodgkin's lymphoma 53.73 26.48 20 9600 895 2347570
Growth failure 53.65 26.48 11 9609 44 2348421
Endocarditis 53.51 26.48 19 9601 742 2347723
Asthma 53.43 26.48 47 9573 11267 2337198
Blood pressure decreased 53.15 26.48 43 9577 9193 2339272
Pulmonary function test decreased 52.99 26.48 17 9603 484 2347981
Abdominal pain lower 52.97 26.48 28 9592 2905 2345560
Rash papular 52.79 26.48 27 9593 2617 2345848
Upper respiratory tract infection 52.62 26.48 42 9578 8809 2339656
Protein urine present 52.55 26.48 18 9602 631 2347834
Tenosynovitis 52.50 26.48 17 9603 499 2347966
Pelvic fracture 52.45 26.48 22 9598 1353 2347112
Guillain-Barre syndrome 52.30 26.48 18 9602 640 2347825
Lymphocytic infiltration 52.27 26.48 14 9606 207 2348258
Enterococcal sepsis 52.16 26.48 13 9607 142 2348323
Graft loss 52.06 26.48 12 9608 91 2348374
Retinal haemorrhage 51.99 26.48 21 9599 1173 2347292
Protein total decreased 51.90 26.48 19 9601 811 2347654
Abdominal pain upper 51.81 26.48 63 9557 22037 2326428
Concomitant disease aggravated 51.70 26.48 20 9600 996 2347469
Chronic graft versus host disease in intestine 51.64 26.48 9 9611 10 2348455
Glomerulosclerosis 51.61 26.48 12 9608 95 2348370
Dry skin 51.58 26.48 37 9583 6615 2341850
Cerebral vasoconstriction 51.53 26.48 15 9605 305 2348160
Cardiogenic shock 51.37 26.48 26 9594 2465 2346000
Central obesity 51.28 26.48 12 9608 98 2348367
Hypertensive crisis 51.16 26.48 26 9594 2487 2345978
Myocardial infarction 50.87 26.48 58 9562 18955 2329510
Rash maculo-papular 50.86 26.48 31 9589 4221 2344244
Concomitant disease progression 50.79 26.48 16 9604 429 2348036
Graft versus host disease in eye 50.32 26.48 9 9611 13 2348452
Red blood cell abnormality 50.24 26.48 12 9608 108 2348357
Lymphadenopathy mediastinal 49.91 26.48 15 9605 342 2348123
Azotaemia 49.84 26.48 17 9603 588 2347877
Renal cell carcinoma 49.84 26.48 18 9602 739 2347726
Cytomegalovirus chorioretinitis 49.73 26.48 13 9607 174 2348291
Adverse reaction 49.46 26.48 22 9598 1562 2346903
Fibrosis 49.27 26.48 16 9604 474 2347991
Sciatica 49.21 26.48 24 9596 2101 2346364
Otitis media 49.04 26.48 17 9603 618 2347847
Dysarthria 48.74 26.48 35 9585 6267 2342198
Pneumonia fungal 48.68 26.48 15 9605 373 2348092
Foetal death 48.54 26.48 23 9597 1889 2346576
Tenderness 48.47 26.48 23 9597 1895 2346570
Haemorrhage 48.44 26.48 44 9576 10995 2337470
Arthropathy 48.43 26.48 37 9583 7279 2341186
Pancreatitis acute 48.43 26.48 29 9591 3824 2344641
Pyoderma gangrenosum 48.31 26.48 16 9604 505 2347960
Red blood cell count decreased 48.22 26.48 30 9590 4236 2344229
Haemoptysis 48.14 26.48 28 9592 3499 2344966
Rash erythematous 48.09 26.48 34 9586 5942 2342523
Pulmonary hypertension 47.99 26.48 32 9588 5086 2343379
Haematoma 47.97 26.48 32 9588 5089 2343376
Pulmonary congestion 47.94 26.48 23 9597 1942 2346523
Renal mass 47.82 26.48 13 9607 204 2348261
Engraftment syndrome 47.46 26.48 10 9610 47 2348418
Encapsulating peritoneal sclerosis 47.32 26.48 11 9609 87 2348378
Shock haemorrhagic 47.18 26.48 20 9600 1263 2347202
Plasmablastic lymphoma 47.12 26.48 10 9610 49 2348416
Lupus nephritis 47.06 26.48 14 9606 308 2348157
Productive cough 46.86 26.48 32 9588 5289 2343176
Hyperlipidaemia 46.80 26.48 25 9595 2649 2345816
Premature rupture of membranes 46.69 26.48 18 9602 888 2347577
Partial seizures 46.57 26.48 18 9602 894 2347571
Glomerulonephritis membranoproliferative 46.47 26.48 10 9610 53 2348412
Infertility 46.45 26.48 12 9608 153 2348312
Hyperuricaemia 45.93 26.48 16 9604 590 2347875
Blindness cortical 45.86 26.48 11 9609 101 2348364
Fluid overload 45.67 26.48 25 9595 2781 2345684
Gastroenteritis norovirus 45.64 26.48 13 9607 244 2348221
Mental status changes 45.47 26.48 32 9588 5550 2342915
Dysuria 45.26 26.48 28 9592 3913 2344552
Sinusitis 45.20 26.48 51 9569 16475 2331990
Ocular vascular disorder 45.19 26.48 11 9609 108 2348357
Ovarian failure 45.10 26.48 13 9607 255 2348210
Mitral valve incompetence 45.08 26.48 24 9596 2526 2345939
Arteriosclerosis 44.33 26.48 20 9600 1468 2346997
Burkholderia cepacia complex infection 44.30 26.48 9 9611 34 2348431
Renal tubular disorder 44.28 26.48 15 9605 508 2347957
Respiratory syncytial virus infection 44.23 26.48 16 9604 660 2347805
Melaena 44.21 26.48 28 9592 4078 2344387
Neutrophilia 44.17 26.48 15 9605 512 2347953
Abdominal tenderness 44.16 26.48 18 9602 1029 2347436
Adjusted calcium decreased 44.16 26.48 8 9612 13 2348452
Visual field defect 43.97 26.48 20 9600 1496 2346969
Cataract 43.84 26.48 32 9588 5876 2342589
Gestational hypertension 43.72 26.48 14 9606 396 2348069
Complications of transplanted liver 43.72 26.48 10 9610 73 2348392
Phaeohyphomycosis 43.70 26.48 9 9611 37 2348428
Lymphocele marsupialisation 43.63 26.48 7 9613 2 2348463
Systemic lupus erythematosus 43.50 26.48 28 9592 4193 2344272
Respiratory tract infection fungal 43.37 26.48 10 9610 76 2348389
Hepatic fibrosis 43.33 26.48 15 9605 543 2347922
Hypoaesthesia 43.17 26.48 55 9565 20160 2328305
Central nervous system lymphoma 42.97 26.48 12 9608 209 2348256
Colitis ulcerative 42.96 26.48 24 9596 2778 2345687
Blood parathyroid hormone decreased 42.92 26.48 12 9608 210 2348255
Drug level below therapeutic 42.91 26.48 14 9606 421 2348044
Septic embolus 42.59 26.48 11 9609 140 2348325
Eczema 42.57 26.48 25 9595 3180 2345285
Cardiac arrest 42.42 26.48 47 9573 14883 2333582
Tricuspid valve incompetence 42.28 26.48 20 9600 1636 2346829
Human polyomavirus infection 42.26 26.48 9 9611 45 2348420
Diabetic macroangiopathy 42.23 26.48 7 9613 4 2348461
Hemiplegia 42.22 26.48 19 9601 1386 2347079
Brain natriuretic peptide increased 42.12 26.48 15 9605 591 2347874
Lymphoma 42.07 26.48 21 9599 1933 2346532
Gastroenteritis clostridial 41.97 26.48 10 9610 89 2348376
Hypercalcaemia 41.93 26.48 23 9597 2569 2345896
Eye infection toxoplasmal 41.77 26.48 9 9611 48 2348417
T-cell lymphoma 41.76 26.48 11 9609 152 2348313
Gastric disorder 41.70 26.48 26 9594 3684 2344781
Ureteric obstruction 41.55 26.48 12 9608 237 2348228
Escherichia bacteraemia 41.53 26.48 13 9607 341 2348124
Pruritus allergic 41.49 26.48 11 9609 156 2348309
Vasculitis 41.49 26.48 22 9598 2296 2346169
Bronchostenosis 41.38 26.48 10 9610 95 2348370
Growth retardation 41.27 26.48 12 9608 243 2348222
Venous thrombosis 41.20 26.48 16 9604 805 2347660
Cardiotoxicity 41.13 26.48 18 9602 1229 2347236
Hypoacusis 41.03 26.48 25 9595 3400 2345065
Nephropathy 41.03 26.48 16 9604 814 2347651
CSF protein increased 40.92 26.48 11 9609 165 2348300
Blood uric acid increased 40.84 26.48 15 9605 646 2347819
Diplopia 40.77 26.48 25 9595 3440 2345025
Moraxella infection 40.73 26.48 9 9611 55 2348410
Liver function test increased 40.69 26.48 24 9596 3077 2345388
Malnutrition 40.67 26.48 20 9600 1783 2346682
Purpura 40.59 26.48 20 9600 1790 2346675
Skin haemorrhage 40.38 26.48 17 9603 1055 2347410
Scleroderma 40.33 26.48 16 9604 852 2347613
American trypanosomiasis 40.31 26.48 8 9612 26 2348439
Ejection fraction decreased 40.26 26.48 23 9597 2778 2345687
Anaemia macrocytic 40.16 26.48 13 9607 381 2348084
Gallbladder disorder 40.01 26.48 23 9597 2811 2345654
Serratia infection 39.97 26.48 10 9610 111 2348354
Pre-existing condition improved 39.97 26.48 14 9606 525 2347940
Hyperglycaemia 39.78 26.48 28 9592 4857 2343608
Drug level fluctuating 39.65 26.48 10 9610 115 2348350
Somnolence 39.65 26.48 57 9563 23428 2325037
Neuropathy peripheral 39.60 26.48 40 9580 11392 2337073
Eye movement disorder 39.56 26.48 17 9603 1110 2347355
Cholecystectomy 39.51 26.48 19 9601 1613 2346852
Cerebral toxoplasmosis 39.41 26.48 10 9610 118 2348347
Hypomagnesaemia 39.41 26.48 22 9598 2542 2345923
Oropharyngeal pain 39.35 26.48 40 9580 11478 2336987
Paraesthesia 39.34 26.48 55 9565 22033 2326432
Overlap syndrome 39.19 26.48 9 9611 67 2348398
Haemorrhage intracranial 39.17 26.48 22 9598 2572 2345893
Rhinorrhoea 39.14 26.48 33 9587 7467 2340998
Post procedural complication 39.12 26.48 23 9597 2931 2345534
Guttate psoriasis 38.96 26.48 10 9610 124 2348341
Magnetic resonance imaging brain abnormal 38.78 26.48 13 9607 426 2348039
Gout 38.47 26.48 18 9602 1437 2347028
Ureteric stenosis 38.45 26.48 10 9610 131 2348334
Complications of transplant surgery 38.40 26.48 9 9611 74 2348391
Pneumocystis jirovecii infection 38.39 26.48 11 9609 211 2348254
Hyperthermia 38.31 26.48 18 9602 1450 2347015
Nasal septum disorder 38.26 26.48 8 9612 36 2348429
MELAS syndrome 38.05 26.48 7 9613 13 2348452
Sjogren's syndrome 37.82 26.48 16 9604 1005 2347460
Encephalitis cytomegalovirus 37.73 26.48 8 9612 39 2348426
Lymphopenia 37.57 26.48 21 9599 2433 2346032
Hypophagia 37.48 26.48 25 9595 3975 2344490
Aplasia 37.46 26.48 13 9607 474 2347991
Subclavian vein thrombosis 37.28 26.48 11 9609 235 2348230
Lymphocyte count increased 37.05 26.48 13 9607 490 2347975
Uveitis 36.79 26.48 18 9602 1587 2346878
Behcet's syndrome 36.60 26.48 10 9610 160 2348305
Red blood cell sedimentation rate abnormal 36.55 26.48 13 9607 510 2347955
Chorioretinopathy 36.55 26.48 11 9609 252 2348213
Drug ineffective for unapproved indication 36.43 26.48 22 9598 2944 2345521
Pleocytosis 36.22 26.48 9 9611 97 2348368
Post transplant distal limb syndrome 36.19 26.48 8 9612 49 2348416
Cystitis 36.17 26.48 28 9592 5614 2342851
Creatinine renal clearance decreased 36.09 26.48 15 9605 901 2347564
Fungal test positive 36.05 26.48 9 9611 99 2348366
Abortion spontaneous 35.92 26.48 41 9579 13404 2335061
Retinal detachment 35.87 26.48 16 9604 1143 2347322
Dyspnoea exertional 35.83 26.48 28 9592 5692 2342773
Respiratory tract infection bacterial 35.78 26.48 8 9612 52 2348413
Insomnia 35.61 26.48 57 9563 25730 2322735
Renal infarct 35.45 26.48 11 9609 280 2348185
Bone marrow transplant 35.45 26.48 10 9610 181 2348284
Skin cancer 35.30 26.48 18 9602 1733 2346732
Abdominal distension 35.28 26.48 36 9584 10375 2338090
Clostridium difficile colitis 35.16 26.48 19 9601 2060 2346405
Renal haematoma 35.15 26.48 8 9612 57 2348408
Stress 35.12 26.48 30 9590 6908 2341557
Body temperature increased 35.08 26.48 22 9598 3149 2345316
Intracranial pressure increased 35.03 26.48 15 9605 971 2347494
Lupus vasculitis 34.99 26.48 7 9613 24 2348441
Intentional product use issue 34.92 26.48 23 9597 3579 2344886
Bowen's disease 34.84 26.48 10 9610 193 2348272
Secretion discharge 34.77 26.48 16 9604 1229 2347236
Nephritis 34.75 26.48 12 9608 431 2348034
Osteomyelitis 34.74 26.48 23 9597 3610 2344855
Myoclonus 34.65 26.48 20 9600 2463 2346002
Transitional cell carcinoma 34.46 26.48 9 9611 120 2348345
Cardiac tamponade 34.43 26.48 14 9606 795 2347670
Glomerulonephritis 34.41 26.48 12 9608 444 2348021
Cutaneous T-cell lymphoma stage IV 34.27 26.48 6 9614 7 2348458
Gastrointestinal necrosis 34.15 26.48 13 9607 619 2347846
Acute coronary syndrome 34.10 26.48 17 9603 1560 2346905
Klebsiella bacteraemia 33.99 26.48 9 9611 127 2348338
Jaw fracture 33.93 26.48 12 9608 463 2348002
Hypercholesterolaemia 33.69 26.48 17 9603 1601 2346864
Antinuclear antibody positive 33.69 26.48 15 9605 1067 2347398
Atypical mycobacterial infection 33.65 26.48 10 9610 219 2348246
Pulmonary mycosis 33.60 26.48 9 9611 133 2348332
Streptococcal infection 33.50 26.48 14 9606 853 2347612
Dizziness 33.47 26.48 90 9530 58575 2289890
Organising pneumonia 33.43 26.48 14 9606 857 2347608
Mastitis 33.35 26.48 12 9608 487 2347978
Serum ferritin decreased 33.15 26.48 10 9610 231 2348234
Central nervous system vasculitis 33.11 26.48 10 9610 232 2348233
Osmotic demyelination syndrome 33.06 26.48 9 9611 142 2348323
Vision blurred 33.04 26.48 41 9579 14627 2333838
Paroxysmal nocturnal haemoglobinuria 33.03 26.48 7 9613 34 2348431
Constipation 32.91 26.48 50 9570 21579 2326886
Impaired healing 32.84 26.48 26 9594 5385 2343080
Carpal tunnel syndrome 32.84 26.48 18 9602 2007 2346458
Wound dehiscence 32.81 26.48 13 9607 690 2347775
Hepatitis cholestatic 32.73 26.48 15 9605 1142 2347323
Eye infection fungal 32.70 26.48 7 9613 36 2348429
Mobility decreased 32.68 26.48 32 9588 8778 2339687
Blood creatinine decreased 32.60 26.48 12 9608 520 2347945
Laparotomy 32.56 26.48 8 9612 82 2348383
Urine protein/creatinine ratio increased 32.54 26.48 7 9613 37 2348428
Herpes zoster disseminated 32.49 26.48 9 9611 152 2348313
Leukaemia in remission 32.42 26.48 5 9615 0 2348465
Engraft failure 32.38 26.48 7 9613 38 2348427
Cardiomyopathy 32.38 26.48 20 9600 2787 2345678
Hepatic haematoma 32.30 26.48 8 9612 85 2348380
Corynebacterium infection 32.30 26.48 8 9612 85 2348380
Cardiac valve vegetation 32.30 26.48 8 9612 85 2348380
Colectomy 32.28 26.48 12 9608 535 2347930
Respiratory gas exchange disorder 32.23 26.48 7 9613 39 2348426
Drug eruption 32.06 26.48 21 9599 3238 2345227
Bone marrow transplant rejection 32.00 26.48 6 9614 13 2348452
Hodgkin's disease 31.78 26.48 12 9608 559 2347906
Hypertensive encephalopathy 31.74 26.48 9 9611 166 2348299
Hepatitis B reactivation 31.67 26.48 10 9610 270 2348195
Acid base balance abnormal 31.51 26.48 7 9613 44 2348421
Pseudomonal sepsis 31.29 26.48 10 9610 281 2348184
Therapeutic response unexpected 31.14 26.48 22 9598 3837 2344628
Extensor plantar response 31.13 26.48 10 9610 286 2348179
Hairy cell leukaemia 31.12 26.48 6 9614 16 2348449
Hyperkeratosis 30.98 26.48 13 9607 800 2347665
Acute hepatic failure 30.92 26.48 19 9601 2623 2345842
Coronary artery stenosis 30.86 26.48 13 9607 808 2347657
Rheumatoid nodule 30.85 26.48 12 9608 606 2347859
Pneumonia lipoid 30.85 26.48 6 9614 17 2348448
Myasthenia gravis 30.78 26.48 12 9608 610 2347855
Bile duct stenosis 30.69 26.48 9 9611 188 2348277
Myositis 30.68 26.48 15 9605 1320 2347145
Hepatitis E 30.60 26.48 9 9611 190 2348275
Meningitis 30.52 26.48 14 9606 1068 2347397
Muscle haemorrhage 30.46 26.48 12 9608 627 2347838
Cardiac failure acute 30.43 26.48 14 9606 1075 2347390
Reticulocyte count increased 30.40 26.48 8 9612 110 2348355
Toxic epidermal necrolysis 30.30 26.48 20 9600 3124 2345341
Steroid diabetes 30.26 26.48 7 9613 54 2348411
Primary effusion lymphoma 30.07 26.48 5 9615 3 2348462
Complications of transplanted heart 29.89 26.48 6 9614 21 2348444
B-cell lymphoma 29.86 26.48 12 9608 661 2347804
Fasciitis 29.76 26.48 8 9612 120 2348345
Polyneuropathy 29.50 26.48 16 9604 1747 2346718
Type IIb hyperlipidaemia 29.48 26.48 5 9615 4 2348461
Blood immunoglobulin G decreased 29.47 26.48 9 9611 217 2348248
Large intestinal ulcer 29.47 26.48 11 9609 496 2347969
Depression 29.42 26.48 55 9565 28077 2320388
Nasopharyngitis 29.42 26.48 48 9572 22008 2326457
Thrombocytosis 29.34 26.48 13 9607 914 2347551
Polyuria 29.34 26.48 14 9606 1168 2347297
Intestinal perforation 29.26 26.48 16 9604 1775 2346690
Necrotising fasciitis 29.20 26.48 11 9609 509 2347956
Rash pruritic 29.13 26.48 28 9592 7507 2340958
Tuberculosis gastrointestinal 29.11 26.48 7 9613 65 2348400
Osteoporotic fracture 29.07 26.48 10 9610 355 2348110
Mass 29.05 26.48 16 9604 1800 2346665
Dyskinesia 29.04 26.48 23 9597 4766 2343699
Cerebral aspergillosis 28.92 26.48 7 9613 67 2348398
Oligohydramnios 28.90 26.48 13 9607 947 2347518
Meningoencephalitis herpetic 28.83 26.48 9 9611 234 2348231
Intestinal infarction 28.79 26.48 9 9611 235 2348230
Haemorrhagic diathesis 28.75 26.48 11 9609 531 2347934
Dermatitis exfoliative 28.69 26.48 14 9606 1227 2347238
Renal injury 28.68 26.48 13 9607 964 2347501
Pneumonia staphylococcal 28.62 26.48 10 9610 372 2348093
Pyuria 28.61 26.48 9 9611 240 2348225
Arterial disorder 28.54 26.48 9 9611 242 2348223
Microangiopathic haemolytic anaemia 28.50 26.48 8 9612 142 2348323
Blood triglycerides increased 28.49 26.48 17 9603 2226 2346239
Mucosal ulceration 28.43 26.48 9 9611 245 2348220
Proteus infection 28.40 26.48 8 9612 144 2348321
Cytogenetic abnormality 28.35 26.48 8 9612 145 2348320
Second primary malignancy 28.32 26.48 13 9607 993 2347472
Hypertrophic cardiomyopathy 28.30 26.48 9 9611 249 2348216
Enterococcal bacteraemia 28.29 26.48 8 9612 146 2348319
Choroidal detachment 28.20 26.48 7 9613 75 2348390
Thrombosis 28.08 26.48 30 9590 9114 2339351
Cerebellar syndrome 28.01 26.48 11 9609 570 2347895
Laser therapy 28.01 26.48 6 9614 31 2348434
Dyspepsia 27.97 26.48 31 9589 9813 2338652
Renal artery stenosis 27.96 26.48 9 9611 259 2348206
Dysplasia 27.89 26.48 8 9612 154 2348311
Myoglobinuria 27.87 26.48 7 9613 79 2348386
Genital cyst 27.65 26.48 5 9615 8 2348457
Neutrophil count increased 27.58 26.48 16 9604 1989 2346476
Malabsorption 27.56 26.48 11 9609 595 2347870
Pneumonia pseudomonal 27.42 26.48 9 9611 276 2348189
Portal venous gas 27.39 26.48 6 9614 35 2348430
Pneumonia klebsiella 27.38 26.48 9 9611 277 2348188
Maculopathy 27.35 26.48 10 9610 425 2348040
Peripheral swelling 27.22 26.48 41 9579 17556 2330909
Clonic convulsion 27.19 26.48 8 9612 169 2348296
Nephrosclerosis 27.19 26.48 8 9612 169 2348296
Pneumonia pneumococcal 27.14 26.48 9 9611 285 2348180
Oxygen saturation decreased 27.11 26.48 27 9593 7559 2340906
Delayed graft function 27.04 26.48 7 9613 90 2348375
Cytomegalovirus gastritis 26.97 26.48 6 9614 38 2348427
Tongue disorder 26.96 26.48 13 9607 1110 2347355
Fungal sepsis 26.93 26.48 8 9612 175 2348290
Blood creatine increased 26.85 26.48 11 9609 637 2347828
Tonsillitis 26.80 26.48 12 9608 865 2347600
Stillbirth 26.71 26.48 14 9606 1427 2347038
Toxic leukoencephalopathy 26.69 26.48 7 9613 95 2348370
Central nervous system viral infection 26.61 26.48 5 9615 11 2348454
Fall 26.59 26.48 72 9548 47027 2301438
Anxiety 26.56 26.48 54 9566 29305 2319160
Crepitations 26.56 26.48 11 9609 655 2347810
Neutrophil count decreased 26.52 26.48 25 9595 6542 2341923

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 2904.00 27.92 690 11544 2611 1731936
Pyrexia 2215.77 27.92 1073 11161 45327 1689220
Graft versus host disease 1799.74 27.92 407 11827 1146 1733401
Blood creatinine increased 1660.19 27.92 620 11614 13326 1721221
Product use in unapproved indication 1500.21 27.92 520 11714 8902 1725645
Renal impairment 1444.35 27.92 542 11692 11772 1722775
Drug ineffective 1419.70 27.92 894 11340 62907 1671640
Posterior reversible encephalopathy syndrome 1223.78 27.92 295 11939 1180 1733367
Kidney transplant rejection 1216.34 27.92 282 11952 912 1733635
Acute graft versus host disease 1150.11 27.92 253 11981 594 1733953
Nephropathy toxic 1038.26 27.92 267 11967 1465 1733082
Pneumonia 1034.22 27.92 652 11582 45530 1689017
Epstein-Barr virus infection 1010.48 27.92 240 11994 885 1733662
Acute graft versus host disease in skin 962.99 27.92 204 12030 368 1734179
Chronic graft versus host disease 945.07 27.92 200 12034 358 1734189
Sepsis 937.02 27.92 456 11778 18982 1715565
Multiple organ dysfunction syndrome 924.56 27.92 363 11871 8879 1725668
Transplant rejection 921.18 27.92 231 12003 1123 1733424
Post transplant lymphoproliferative disorder 913.38 27.92 205 12029 545 1734002
Graft versus host disease in gastrointestinal tract 879.58 27.92 179 12055 234 1734313
Hypertension 858.98 27.92 430 11804 19018 1715529
Acute kidney injury 839.90 27.92 517 11717 34427 1700120
Renal failure 714.95 27.92 384 11850 19633 1714914
Hepatic function abnormal 651.36 27.92 262 11972 6812 1727735
Respiratory failure 649.08 27.92 324 11910 14181 1720366
Complications of transplanted kidney 615.86 27.92 143 12091 463 1734084
Graft versus host disease in skin 609.50 27.92 133 12101 294 1734253
Pancytopenia 608.25 27.92 287 11947 11070 1723477
Aspergillus infection 600.20 27.92 165 12069 1208 1733339
Immunosuppressant drug level increased 593.78 27.92 138 12096 449 1734098
Thrombotic microangiopathy 577.06 27.92 158 12076 1137 1733410
Acute graft versus host disease in intestine 542.68 27.92 114 12120 192 1734355
Proteinuria 537.03 27.92 179 12055 2665 1731882
Diarrhoea 529.78 27.92 465 11769 53387 1681160
Bronchopulmonary aspergillosis 520.72 27.92 152 12082 1414 1733133
Cystitis haemorrhagic 474.45 27.92 118 12116 548 1733999
Epstein-Barr virus associated lymphoproliferative disorder 472.49 27.92 104 12130 243 1734304
Pain in extremity 430.72 27.92 269 11965 18203 1716344
BK virus infection 428.90 27.92 102 12132 376 1734171
Squamous cell carcinoma 422.91 27.92 135 12099 1736 1732811
Stomatitis 418.43 27.92 177 12057 5227 1729320
Kaposi's sarcoma 415.19 27.92 112 12122 755 1733792
Heart transplant rejection 403.11 27.92 83 12151 119 1734428
Drug interaction 395.35 27.92 299 11935 27659 1706888
Septic shock 391.31 27.92 191 12043 7918 1726629
Headache 390.35 27.92 323 11911 34053 1700494
Abdominal pain 372.25 27.92 260 11974 21230 1713317
Dyspnoea 368.15 27.92 375 11859 51684 1682863
Cytomegalovirus test positive 364.67 27.92 91 12143 429 1734118
Pneumocystis jirovecii pneumonia 360.11 27.92 128 12106 2328 1732219
Nephrotic syndrome 356.68 27.92 111 12123 1305 1733242
Drug eruption 352.79 27.92 132 12102 2794 1731753
Diabetes mellitus 352.20 27.92 169 12065 6739 1727808
Adenovirus infection 350.08 27.92 86 12148 375 1734172
Neurotoxicity 348.79 27.92 119 12115 1905 1732642
Liver transplant rejection 348.61 27.92 86 12148 383 1734164
Leukopenia 345.16 27.92 178 12056 8302 1726245
Gingival hypertrophy 344.16 27.92 82 12152 305 1734242
Lymphadenopathy 339.30 27.92 141 12093 3973 1730574
Chronic graft versus host disease in skin 337.45 27.92 65 12169 48 1734499
Seizure 336.95 27.92 240 11994 20201 1714346
Mucormycosis 336.62 27.92 92 12142 655 1733892
Thrombocytopenia 333.15 27.92 242 11992 21007 1713540
Nausea 331.63 27.92 352 11882 50844 1683703
Haemophagocytic lymphohistiocytosis 328.47 27.92 105 12129 1355 1733192
Toxicity to various agents 326.69 27.92 272 11962 28869 1705678
Rhabdomyolysis 324.26 27.92 187 12047 10903 1723644
Disease recurrence 320.47 27.92 119 12115 2463 1732084
Off label use 319.05 27.92 303 11931 38268 1696279
Acute graft versus host disease in liver 318.76 27.92 67 12167 113 1734434
C-reactive protein increased 318.36 27.92 150 12084 5735 1728812
Platelet count decreased 314.47 27.92 212 12022 16311 1718236
Chronic allograft nephropathy 310.07 27.92 67 12167 138 1734409
Anaemia 309.70 27.92 265 11969 29192 1705355
Lymphoproliferative disorder 303.32 27.92 77 12157 394 1734153
Condition aggravated 302.56 27.92 228 12006 20922 1713625
Haemodialysis 300.76 27.92 114 12120 2502 1732045
Immunosuppressant drug level decreased 300.39 27.92 67 12167 170 1734377
Blood urea increased 295.19 27.92 133 12101 4578 1729969
Basal cell carcinoma 291.95 27.92 110 12124 2373 1732174
Blood bilirubin increased 289.64 27.92 143 12091 6067 1728480
Hypersensitivity 289.10 27.92 170 12064 10274 1724273
Vomiting 288.61 27.92 286 11948 38029 1696518
Epistaxis 277.74 27.92 153 12081 8153 1726394
Therapy non-responder 276.60 27.92 139 12095 6127 1728420
Haemoglobin decreased 275.08 27.92 198 12036 16916 1717631
Pseudomonas infection 273.78 27.92 89 12145 1215 1733332
Skin lesion 272.75 27.92 110 12124 2862 1731685
Product use issue 270.53 27.92 152 12082 8419 1726128
Staphylococcal infection 270.08 27.92 125 12109 4582 1729965
Blood lactate dehydrogenase increased 269.82 27.92 116 12118 3559 1730988
Interstitial lung disease 268.79 27.92 158 12076 9538 1725009
Infection 265.17 27.92 171 12063 12189 1722358
Pleural effusion 261.51 27.92 163 12071 10947 1723600
Chronic kidney disease 261.33 27.92 119 12115 4198 1730349
Alanine aminotransferase increased 258.80 27.92 168 12066 12110 1722437
Cough 256.95 27.92 199 12035 18998 1715549
Cytomegalovirus viraemia 255.62 27.92 70 12164 502 1734045
Squamous cell carcinoma of skin 253.59 27.92 83 12151 1159 1733388
Urinary tract infection 251.74 27.92 154 12080 9999 1724548
Lymphocele 247.29 27.92 55 12179 137 1734410
Renal tubular necrosis 242.31 27.92 92 12142 2027 1732520
Enterococcal infection 241.08 27.92 74 12160 827 1733720
Treatment failure 240.46 27.92 113 12121 4288 1730259
Graft versus host disease in liver 238.71 27.92 50 12184 82 1734465
Haematuria 238.34 27.92 134 12100 7426 1727121
Pneumonia cytomegaloviral 237.42 27.92 61 12173 330 1734217
Mucosal inflammation 236.93 27.92 110 12124 4059 1730488
Psoriasis 235.04 27.92 155 12079 11470 1723077
Drug level increased 235.04 27.92 97 12137 2680 1731867
Urticaria 234.94 27.92 158 12076 12083 1722464
Transplant dysfunction 234.71 27.92 60 12174 317 1734230
Diffuse large B-cell lymphoma 232.72 27.92 76 12158 1053 1733494
Febrile neutropenia 231.72 27.92 151 12083 10949 1723598
Bone marrow failure 225.47 27.92 114 12120 5086 1729461
Muscular weakness 222.72 27.92 143 12091 10106 1724441
Kidney fibrosis 220.07 27.92 57 12177 320 1734227
Neutropenia 220.04 27.92 178 12056 18082 1716465
Lung infiltration 219.29 27.92 86 12148 2073 1732474
Urine output decreased 217.37 27.92 77 12157 1383 1733164
Renal disorder 214.27 27.92 102 12132 3984 1730563
General physical health deterioration 213.45 27.92 153 12081 12965 1721582
Erythema 211.64 27.92 157 12077 14031 1720516
Muscle spasms 211.08 27.92 145 12089 11476 1723071
Renal transplant failure 210.55 27.92 48 12186 139 1734408
Obliterative bronchiolitis 206.52 27.92 50 12184 202 1734345
Oedema 205.11 27.92 118 12116 6830 1727717
Progressive multifocal leukoencephalopathy 204.99 27.92 76 12158 1563 1732984
Acute respiratory distress syndrome 202.70 27.92 94 12140 3457 1731090
Drug resistance 201.65 27.92 91 12143 3139 1731408
Encephalopathy 200.03 27.92 100 12134 4352 1730195
Aspartate aminotransferase increased 199.58 27.92 136 12098 10620 1723927
Ascites 197.98 27.92 107 12127 5479 1729068
Focal segmental glomerulosclerosis 194.81 27.92 50 12184 269 1734278
Lung transplant rejection 192.55 27.92 41 12193 76 1734471
Oedema peripheral 186.02 27.92 151 12083 15399 1719148
Vein rupture 184.93 27.92 37 12197 41 1734506
Bacterial infection 183.47 27.92 73 12161 1829 1732718
Aplastic anaemia 182.43 27.92 57 12177 678 1733869
Herpes zoster 180.13 27.92 94 12140 4479 1730068
Lung disorder 178.46 27.92 97 12137 5022 1729525
Candida infection 177.97 27.92 72 12162 1886 1732661
Oliguria 177.63 27.92 63 12171 1135 1733412
Fungal infection 174.56 27.92 74 12160 2188 1732359
Surgery 173.45 27.92 79 12155 2784 1731763
Escherichia infection 173.40 27.92 59 12175 934 1733613
Hypogammaglobulinaemia 168.89 27.92 52 12182 587 1733960
Myalgia 168.45 27.92 143 12091 15515 1719032
Transplant failure 168.09 27.92 47 12187 367 1734180
Hypoxia 167.28 27.92 98 12136 5865 1728682
Polyomavirus-associated nephropathy 164.84 27.92 47 12187 397 1734150
JC virus infection 163.39 27.92 40 12194 171 1734376
Cardiac failure 162.67 27.92 128 12106 12474 1722073
Concomitant disease progression 160.78 27.92 48 12186 484 1734063
Complications of bone marrow transplant 159.68 27.92 32 12202 36 1734511
Hydronephrosis 159.54 27.92 60 12174 1285 1733262
Chronic graft versus host disease in intestine 158.82 27.92 30 12204 17 1734530
Therapeutic response decreased 158.53 27.92 92 12142 5408 1729139
Enthesopathy 157.97 27.92 34 12200 68 1734479
Cholestasis 154.88 27.92 79 12155 3586 1730961
Rash 152.24 27.92 207 12027 38486 1696061
Pneumomediastinum 151.92 27.92 41 12193 276 1734271
Graft loss 151.36 27.92 38 12196 184 1734363
Weight decreased 151.07 27.92 159 12075 22594 1711953
Thrombotic thrombocytopenic purpura 150.72 27.92 49 12185 668 1733879
Inflammation 150.55 27.92 76 12158 3374 1731173
Tenosynovitis 149.95 27.92 40 12194 256 1734291
Chronic graft versus host disease in liver 148.00 27.92 29 12205 26 1734521
Generalised tonic-clonic seizure 147.52 27.92 79 12155 3967 1730580
Liver function test abnormal 147.29 27.92 89 12145 5637 1728910
Haemolytic uraemic syndrome 146.74 27.92 43 12191 404 1734143
Oral administration complication 146.46 27.92 29 12205 29 1734518
Respiratory distress 145.28 27.92 85 12149 5072 1729475
Low birth weight baby 144.35 27.92 50 12184 837 1733710
Blood pressure increased 142.60 27.92 111 12123 10642 1723905
Blood creatine phosphokinase increased 140.97 27.92 102 12132 8754 1725793
Blood albumin decreased 140.87 27.92 58 12176 1590 1732957
Bacteraemia 140.07 27.92 60 12174 1820 1732727
Hepatic failure 139.71 27.92 87 12147 5816 1728731
Disease progression 139.06 27.92 134 12100 17129 1717418
Hepatitis C 138.05 27.92 67 12167 2729 1731818
Drug intolerance 137.58 27.92 87 12147 5975 1728572
Nephrectomy 136.94 27.92 33 12201 130 1734417
Ureteric stenosis 136.75 27.92 34 12200 157 1734390
Death 136.61 27.92 311 11923 87132 1647415
Foetal exposure during pregnancy 136.23 27.92 88 12146 6271 1728276
Escherichia sepsis 134.99 27.92 44 12190 605 1733942
Hepatic enzyme increased 132.99 27.92 88 12146 6533 1728014
Venoocclusive disease 132.95 27.92 38 12196 324 1734223
Staphylococcal sepsis 132.08 27.92 51 12183 1176 1733371
B-cell lymphoma 131.87 27.92 46 12188 787 1733760
Premature baby 131.86 27.92 66 12168 2876 1731671
Herpes simplex 131.53 27.92 44 12190 659 1733888
Mechanical ventilation 130.55 27.92 37 12197 305 1734242
Human herpesvirus 6 infection 130.44 27.92 38 12196 349 1734198
Skin mass 130.37 27.92 42 12192 555 1733992
Pneumonia fungal 129.94 27.92 40 12194 451 1734096
Nephropathy 129.88 27.92 47 12187 899 1733648
Asthenia 129.56 27.92 181 12053 34489 1700058
Klebsiella infection 129.00 27.92 45 12189 770 1733777
Brain oedema 127.99 27.92 59 12175 2137 1732410
Blood alkaline phosphatase increased 126.57 27.92 78 12156 5117 1729430
Toxoplasmosis 125.06 27.92 31 12203 141 1734406
Nodule 125.02 27.92 45 12189 847 1733700
Pyelonephritis 125.01 27.92 43 12191 704 1733843
Cushingoid 121.37 27.92 36 12198 354 1734193
White blood cell count decreased 121.11 27.92 110 12124 13039 1721508
Confusional state 120.82 27.92 137 12097 21141 1713406
Red blood cell count decreased 120.58 27.92 67 12167 3619 1730928
Anuria 120.37 27.92 54 12180 1834 1732713
Gamma-glutamyltransferase increased 120.28 27.92 75 12159 5023 1729524
Hirsutism 120.10 27.92 25 12209 39 1734508
Endotracheal intubation 119.41 27.92 37 12197 427 1734120
Pneumonia bacterial 119.23 27.92 47 12187 1147 1733400
Depressed level of consciousness 118.97 27.92 82 12152 6510 1728037
Bacterial sepsis 118.42 27.92 40 12194 618 1733929
Renal tubular atrophy 117.63 27.92 31 12203 188 1734359
Leukaemia recurrent 117.08 27.92 33 12201 266 1734281
Peritonitis 115.59 27.92 59 12175 2680 1731867
Hyperkalaemia 114.96 27.92 89 12145 8458 1726089
Hepatotoxicity 114.61 27.92 61 12173 3023 1731524
Lymphopenia 113.43 27.92 53 12181 1980 1732567
End stage renal disease 113.29 27.92 38 12196 574 1733973
Myopathy 112.86 27.92 51 12183 1762 1732785
Glomerulonephritis membranous 112.83 27.92 31 12203 225 1734322
Mycobacterial infection 111.93 27.92 32 12202 273 1734274
Central nervous system lesion 111.78 27.92 43 12191 981 1733566
C-reactive protein abnormal 111.54 27.92 31 12203 236 1734311
Acute myeloid leukaemia recurrent 111.20 27.92 31 12203 239 1734308
Cellulitis 110.97 27.92 78 12156 6390 1728157
Psoriatic arthropathy 110.13 27.92 54 12180 2249 1732298
Synovitis 109.75 27.92 39 12195 706 1733841
Tubulointerstitial nephritis 108.49 27.92 58 12176 2900 1731647
Jaundice 108.43 27.92 75 12159 5987 1728560
Engraftment syndrome 108.01 27.92 25 12209 79 1734468
Blood stem cell transplant failure 107.60 27.92 21 12213 18 1734529
Actinic keratosis 107.13 27.92 36 12198 547 1734000
Complications of transplanted heart 106.85 27.92 23 12211 46 1734501
Lymphoma 106.12 27.92 51 12183 2031 1732516
Disseminated intravascular coagulation 105.56 27.92 61 12173 3553 1730994
Decreased appetite 104.94 27.92 135 12099 23736 1710811
Generalised oedema 104.82 27.92 48 12186 1711 1732836
Autoimmune haemolytic anaemia 104.60 27.92 38 12196 735 1733812
Liver disorder 103.80 27.92 71 12163 5565 1728982
Hyperkeratosis 103.62 27.92 36 12198 608 1733939
Malaise 102.48 27.92 149 12085 29416 1705131
Chills 102.21 27.92 95 12139 11592 1722955
Arthralgia 102.14 27.92 132 12102 23312 1711235
Nocardiosis 102.13 27.92 34 12200 501 1734046
Hyperbilirubinaemia 101.57 27.92 51 12183 2236 1732311
Transaminases increased 101.00 27.92 61 12173 3856 1730691
Graft versus host disease in lung 100.61 27.92 22 12212 49 1734498
Osteonecrosis 100.36 27.92 61 12173 3901 1730646
Shock 100.13 27.92 62 12172 4099 1730448
Plasmacytoma 99.78 27.92 33 12201 476 1734071
Altered state of consciousness 99.41 27.92 58 12176 3439 1731108
Haemolytic anaemia 99.13 27.92 47 12187 1815 1732732
Acute lymphocytic leukaemia recurrent 98.90 27.92 29 12205 273 1734274
Epstein-Barr viraemia 98.32 27.92 24 12210 101 1734446
Pulmonary oedema 98.31 27.92 73 12161 6513 1728034
Venoocclusive liver disease 97.64 27.92 38 12196 895 1733652
Tongue disorder 97.03 27.92 33 12201 521 1734026
Dysuria 96.79 27.92 58 12176 3614 1730933
Splenomegaly 96.28 27.92 48 12186 2072 1732475
White blood cell count increased 95.84 27.92 75 12159 7237 1727310
Scedosporium infection 95.12 27.92 24 12210 119 1734428
Blindness 94.67 27.92 52 12182 2744 1731803
Stem cell transplant 94.44 27.92 31 12203 436 1734111
Disseminated tuberculosis 93.93 27.92 32 12202 508 1734039
Acute myeloid leukaemia 93.28 27.92 53 12181 2988 1731559
Haemolysis 93.14 27.92 39 12195 1116 1733431
Wound dehiscence 93.09 27.92 33 12201 593 1733954
Glomerulonephritis 92.92 27.92 31 12203 460 1734087
Hepatitis B 92.21 27.92 41 12193 1362 1733185
Engraft failure 91.94 27.92 20 12214 43 1734504
Abscess 91.43 27.92 45 12189 1889 1732658
Hepatitis cholestatic 91.33 27.92 40 12194 1281 1733266
Pericardial effusion 90.53 27.92 54 12180 3336 1731211
Impaired healing 90.19 27.92 49 12185 2530 1732017
Behcet's syndrome 90.18 27.92 23 12211 120 1734427
Cerebral toxoplasmosis 90.17 27.92 24 12210 152 1734395
Dyspnoea exertional 90.11 27.92 58 12176 4103 1730444
Bowen's disease 88.79 27.92 27 12207 291 1734256
Gastrointestinal haemorrhage 88.03 27.92 96 12138 14171 1720376
Dialysis 87.77 27.92 47 12187 2357 1732190
Viral infection 87.77 27.92 50 12184 2833 1731714
Rhinovirus infection 86.38 27.92 26 12208 270 1734277
Diarrhoea haemorrhagic 86.20 27.92 36 12198 1023 1733524
Alternaria infection 85.49 27.92 19 12215 47 1734500
Renal vessel disorder 85.49 27.92 19 12215 47 1734500
Hyperuricaemia 85.44 27.92 35 12199 946 1733601
Hepatosplenomegaly 85.02 27.92 31 12203 606 1733941
Alveolar proteinosis 84.84 27.92 20 12214 70 1734477
Pulmonary haemorrhage 84.71 27.92 41 12193 1658 1732889
Drug level decreased 84.32 27.92 35 12199 979 1733568
Toxic encephalopathy 84.00 27.92 32 12202 710 1733837
Lymphocyte count decreased 83.14 27.92 44 12190 2154 1732393
Laparotomy 82.94 27.92 20 12214 79 1734468
Cutaneous T-cell lymphoma 82.67 27.92 26 12208 316 1734231
Tremor 82.13 27.92 89 12145 13042 1721505
Spermatozoa progressive motility decreased 81.85 27.92 19 12215 61 1734486
Renal transplant 81.72 27.92 27 12207 388 1734159
Haemodynamic instability 81.28 27.92 37 12197 1300 1733247
Urosepsis 81.15 27.92 38 12196 1426 1733121
Human herpesvirus 8 infection 80.85 27.92 20 12214 90 1734457
Encephalitis 80.43 27.92 35 12199 1103 1733444
Serum ferritin increased 79.63 27.92 32 12202 822 1733725
Venous injury 79.49 27.92 18 12216 50 1734497
Cytomegalovirus colitis 79.48 27.92 25 12209 304 1734243
Pneumatosis intestinalis 79.45 27.92 28 12206 494 1734053
Skin papilloma 79.45 27.92 26 12208 362 1734185
Hepatitis B reactivation 79.32 27.92 26 12208 364 1734183
Haematocrit decreased 79.07 27.92 54 12180 4219 1730328
Aplasia 78.99 27.92 27 12207 433 1734114
Osteoporosis 78.97 27.92 38 12196 1517 1733030
Acute respiratory failure 78.94 27.92 47 12187 2893 1731654
Viral test positive 78.61 27.92 19 12215 76 1734471
Leukocytosis 78.37 27.92 50 12184 3483 1731064
Respiratory syncytial virus infection 77.94 27.92 30 12204 685 1733862
Mouth ulceration 77.53 27.92 39 12195 1716 1732831
Graft versus host disease in eye 76.46 27.92 16 12218 26 1734521
Visual acuity reduced 76.40 27.92 51 12183 3837 1730710
Respiratory disorder 75.96 27.92 47 12187 3102 1731445
Metastases to lymph nodes 75.77 27.92 31 12203 835 1733712
Pseudomonal sepsis 75.62 27.92 25 12209 360 1734187
Brain abscess 75.22 27.92 26 12208 432 1734115
Glomerular filtration rate decreased 75.19 27.92 36 12198 1421 1733126
Enterococcal sepsis 74.97 27.92 21 12213 165 1734382
Leukoencephalopathy 74.68 27.92 30 12204 770 1733777
Plasmablastic lymphoma 74.35 27.92 17 12217 50 1734497
Papule 74.01 27.92 28 12206 609 1733938
Bronchiectasis 73.66 27.92 27 12207 536 1734011
Pain 73.59 27.92 121 12113 26536 1708011
Lung neoplasm 73.54 27.92 29 12205 708 1733839
Uveitis 73.22 27.92 32 12202 1019 1733528
Rash erythematous 73.11 27.92 50 12184 3915 1730632
Trichophytic granuloma 72.85 27.92 14 12220 10 1734537
Gait disturbance 72.54 27.92 82 12152 12588 1721959
Cryptococcosis 72.15 27.92 23 12211 293 1734254
Legionella infection 72.12 27.92 19 12215 115 1734432
Hypoalbuminaemia 72.09 27.92 35 12199 1425 1733122
Red blood cell schistocytes present 71.78 27.92 17 12217 61 1734486
Hepatitis E 71.78 27.92 22 12212 244 1734303
Cerebral infarction 71.66 27.92 55 12179 5154 1729393
Skin exfoliation 71.57 27.92 52 12182 4483 1730064
Dehydration 71.55 27.92 96 12138 17562 1716985
Loss of personal independence in daily activities 71.39 27.92 41 12193 2358 1732189
Blood uric acid increased 71.20 27.92 31 12203 978 1733569
Life support 70.94 27.92 17 12217 65 1734482
Hepatic fibrosis 70.87 27.92 27 12207 599 1733948
Acinetobacter infection 70.86 27.92 20 12214 162 1734385
Gastroenteritis norovirus 69.50 27.92 20 12214 175 1734372
Haemorrhage 69.24 27.92 71 12163 9758 1724789
Myelodysplastic syndrome 69.13 27.92 45 12189 3244 1731303
Pruritus 68.98 27.92 109 12125 23113 1711434
Skin plaque 68.56 27.92 29 12205 851 1733696
Gastroenteritis 68.46 27.92 38 12196 2046 1732501
Renal artery stenosis 68.26 27.92 21 12213 236 1734311
Haemoptysis 68.21 27.92 52 12182 4824 1729723
Granuloma 68.12 27.92 25 12209 498 1734049
Agranulocytosis 68.08 27.92 46 12188 3530 1731017
Aplasia pure red cell 67.76 27.92 30 12204 986 1733561
Guillain-Barre syndrome 67.54 27.92 29 12205 884 1733663
Hepatitis 67.46 27.92 52 12182 4903 1729644
Varicella 67.28 27.92 23 12211 369 1734178
Cystitis viral 67.24 27.92 15 12219 38 1734509
Sweat gland tumour 67.22 27.92 16 12218 59 1734488
Lymphocytic infiltration 67.21 27.92 20 12214 199 1734348
Papilloedema 66.69 27.92 26 12208 615 1733932
Epilepsy 66.15 27.92 47 12187 3912 1730635
Fungal test positive 65.67 27.92 17 12217 95 1734452
Post transplant distal limb syndrome 65.64 27.92 15 12219 44 1734503
Hypotension 65.47 27.92 122 12112 29532 1705015
Cataract 65.43 27.92 42 12192 2956 1731591
Azotaemia 65.28 27.92 27 12207 748 1733799
Brain stem syndrome 65.23 27.92 18 12216 133 1734414
Alanine aminotransferase abnormal 64.99 27.92 20 12214 225 1734322
Upper respiratory tract infection 64.75 27.92 47 12187 4046 1730501
Pulmonary mass 64.74 27.92 32 12202 1355 1733192
Hypertrichosis 64.65 27.92 17 12217 102 1734445
Metastases to lung 64.56 27.92 33 12201 1502 1733045
Pseudomembranous colitis 64.53 27.92 24 12210 497 1734050
CSF protein increased 64.40 27.92 19 12215 183 1734364
Lung consolidation 64.38 27.92 25 12209 585 1733962
Complications of transplant surgery 64.23 27.92 17 12217 105 1734442
Cytomegalovirus chorioretinitis 63.34 27.92 22 12212 371 1734176
Non-Hodgkin's lymphoma 63.33 27.92 28 12206 917 1733630
Pulmonary tuberculosis 63.22 27.92 29 12205 1037 1733510
Gout 62.98 27.92 39 12195 2577 1731970
Abdominal pain upper 62.63 27.92 71 12163 10930 1723617
Pancreatitis acute 62.54 27.92 46 12188 4041 1730506
Immunosuppression 62.45 27.92 27 12207 837 1733710
Fungal sepsis 62.30 27.92 18 12216 160 1734387
American trypanosomiasis 62.17 27.92 13 12221 21 1734526
Respiratory tract infection 62.14 27.92 38 12196 2455 1732092
Herpes virus infection 62.13 27.92 23 12211 470 1734077
Computerised tomogram abnormal 62.12 27.92 22 12212 394 1734153
Protein total decreased 62.07 27.92 25 12209 646 1733901
Protein urine present 61.92 27.92 25 12209 650 1733897
Klebsiella sepsis 61.64 27.92 19 12215 215 1734332
Debridement 61.33 27.92 19 12215 219 1734328
Glomerulosclerosis 61.28 27.92 16 12218 93 1734454
Tuberculosis 61.23 27.92 34 12200 1832 1732715
Neurological symptom 60.98 27.92 25 12209 677 1733870
Fluid overload 60.83 27.92 35 12199 2020 1732527
Adenoviral haemorrhagic cystitis 60.78 27.92 14 12220 43 1734504
Acquired gene mutation 60.67 27.92 18 12216 177 1734370
Partial seizures 60.67 27.92 25 12209 686 1733861
Phaeohyphomycosis 60.53 27.92 17 12217 135 1734412
Cholangitis 60.20 27.92 29 12205 1160 1733387
Liver abscess 60.06 27.92 24 12210 607 1733940
Myopathy toxic 59.88 27.92 16 12218 103 1734444
Blood beta-D-glucan increased 59.67 27.92 15 12219 73 1734474
Acidosis 59.55 27.92 31 12203 1466 1733081
Pustular psoriasis 59.19 27.92 21 12213 378 1734169
Aphthous ulcer 59.19 27.92 25 12209 731 1733816
Injection site haemorrhage 58.88 27.92 38 12196 2699 1731848
Opportunistic infection 58.78 27.92 20 12214 316 1734231
Trichophytosis 58.53 27.92 14 12220 53 1734494
Skin ulcer 58.23 27.92 38 12196 2750 1731797
Organising pneumonia 58.23 27.92 26 12208 872 1733675
Foetal growth restriction 58.19 27.92 24 12210 660 1733887
Fusarium infection 58.12 27.92 16 12218 117 1734430
Sebaceous hyperplasia 57.92 27.92 12 12222 18 1734529
Pulmonary alveolar haemorrhage 57.73 27.92 28 12206 1137 1733410
Metastases to liver 57.64 27.92 35 12199 2232 1732315
Malignant melanoma 57.37 27.92 31 12203 1582 1732965
Pneumonia klebsiella 57.32 27.92 20 12214 342 1734205
Rash pustular 57.30 27.92 28 12206 1156 1733391
Intestinal perforation 57.26 27.92 31 12203 1588 1732959
Clostridium difficile infection 57.21 27.92 32 12202 1749 1732798
Visual impairment 57.15 27.92 52 12182 6166 1728381
Papilloma viral infection 57.04 27.92 15 12219 90 1734457
Oesophageal squamous cell carcinoma 56.77 27.92 14 12220 62 1734485
Pneumothorax 56.73 27.92 37 12197 2675 1731872
Microangiopathic haemolytic anaemia 56.65 27.92 16 12218 130 1734417
Nephrosclerosis 56.52 27.92 17 12217 176 1734371
Coombs positive haemolytic anaemia 56.49 27.92 15 12219 94 1734453
Hemiparesis 56.46 27.92 37 12197 2697 1731850
Colectomy 56.46 27.92 21 12213 435 1734112
Tachypnoea 56.37 27.92 35 12199 2323 1732224
Mental status changes 56.21 27.92 51 12183 6024 1728523
Ureteric obstruction 56.06 27.92 18 12216 235 1734312
West Nile viral infection 55.95 27.92 15 12219 98 1734449
Hyporeflexia 55.92 27.92 20 12214 369 1734178
Renal tubular disorder 55.67 27.92 25 12209 850 1733697
Electroencephalogram abnormal 55.61 27.92 23 12211 637 1733910
Device related infection 54.82 27.92 34 12200 2252 1732295
Citrobacter infection 54.73 27.92 14 12220 74 1734473
Osteomyelitis 54.70 27.92 34 12200 2261 1732286
Haemorrhage intracranial 54.62 27.92 39 12195 3271 1731276
Biopsy kidney abnormal 54.60 27.92 13 12221 48 1734499
Loss of consciousness 54.41 27.92 77 12157 14798 1719749
Subcutaneous abscess 54.09 27.92 23 12211 684 1733863
Paraesthesia 53.71 27.92 64 12170 10387 1724160
Metastasis 53.50 27.92 24 12210 814 1733733
Pathogen resistance 53.44 27.92 26 12208 1063 1733484
Hepatomegaly 53.37 27.92 30 12204 1655 1732892
Necrosis 53.26 27.92 25 12209 943 1733604
Tachycardia 53.19 27.92 70 12164 12558 1721989
Systemic candida 53.15 27.92 19 12215 350 1734197
Status epilepticus 53.08 27.92 32 12202 2014 1732533
Epstein-Barr virus associated lymphoma 52.96 27.92 14 12220 86 1734461
Injection site papule 52.96 27.92 14 12220 86 1734461
Sinusitis 52.60 27.92 46 12188 5177 1729370
Incision site pain 52.56 27.92 15 12219 127 1734420
Reticulocyte count increased 52.41 27.92 14 12220 90 1734457
Bone marrow transplant rejection 52.31 27.92 12 12222 36 1734511
Erythema infectiosum 52.28 27.92 13 12221 60 1734487
Pneumonia viral 52.26 27.92 19 12215 368 1734179
Lung abscess 52.19 27.92 20 12214 451 1734096
Cachexia 52.10 27.92 25 12209 991 1733556
Productive cough 51.77 27.92 39 12195 3552 1730995
Ulcer 51.65 27.92 26 12208 1145 1733402
Colitis ulcerative 51.61 27.92 34 12200 2500 1732047
Oral disorder 51.52 27.92 22 12212 661 1733886
Apoptosis 51.26 27.92 13 12221 66 1734481
Epstein-Barr virus antibody positive 51.02 27.92 14 12220 101 1734446
Renal lymphocele 51.01 27.92 10 12224 9 1734538
Cerebral haemorrhage 50.96 27.92 49 12185 6228 1728319
Haptoglobin decreased 50.90 27.92 14 12220 102 1734445
Cancer surgery 50.90 27.92 14 12220 102 1734445
Hyperlipidaemia 50.55 27.92 32 12202 2197 1732350
Human ehrlichiosis 50.50 27.92 10 12224 10 1734537
Cytomegalovirus enteritis 50.47 27.92 12 12222 44 1734503
Lung adenocarcinoma 50.41 27.92 22 12212 698 1733849
Candida sepsis 50.39 27.92 16 12218 201 1734346
Coma 50.30 27.92 52 12182 7210 1727337
Meningoencephalitis herpetic 50.24 27.92 16 12218 203 1734344
Malabsorption 50.23 27.92 19 12215 413 1734134
Pneumonia adenoviral 49.84 27.92 11 12223 26 1734521
Hepatic necrosis 49.80 27.92 22 12212 719 1733828
Viral haemorrhagic cystitis 49.72 27.92 13 12221 76 1734471
Disseminated cryptococcosis 49.54 27.92 14 12220 114 1734433
Concomitant disease aggravated 49.46 27.92 22 12212 731 1733816
Metabolic acidosis 49.29 27.92 45 12189 5357 1729190
Atrial fibrillation 49.14 27.92 74 12160 15037 1719510
Insomnia 49.13 27.92 77 12157 16199 1718348
Pancreatitis 48.95 27.92 51 12183 7136 1727411
Cytomegalovirus hepatitis 48.87 27.92 12 12222 52 1734495
Hepatic neoplasm 48.34 27.92 18 12216 374 1734173
Osmotic demyelination syndrome 48.09 27.92 15 12219 177 1734370
Hypercholesterolaemia 47.92 27.92 25 12209 1187 1733360
Malnutrition 47.69 27.92 27 12207 1510 1733037
Bile duct stenosis 47.61 27.92 16 12218 243 1734304
Cardiac arrest 47.58 27.92 75 12159 15855 1718692
Pneumonia pseudomonal 47.51 27.92 18 12216 393 1734154
Gastritis 47.50 27.92 35 12199 3082 1731465
Blister 47.27 27.92 39 12195 4053 1730494
Hepatitis viral 47.07 27.92 14 12220 139 1734408
Cholelithiasis 47.02 27.92 35 12199 3130 1731417
Enterobacter infection 46.84 27.92 16 12218 256 1734291
Neoplasm skin 46.80 27.92 14 12220 142 1734405
Encephalitis viral 46.63 27.92 15 12219 197 1734350
Clostridium difficile colitis 46.62 27.92 27 12207 1577 1732970
Growth retardation 46.56 27.92 19 12215 508 1734039
Colitis 46.54 27.92 39 12195 4141 1730406
Perirenal haematoma 46.52 27.92 12 12222 66 1734481
Aphasia 46.40 27.92 36 12198 3425 1731122
Rash maculo-papular 46.38 27.92 37 12197 3666 1730881
Human polyomavirus infection 46.21 27.92 12 12222 68 1734479
Injection site swelling 45.99 27.92 35 12199 3236 1731311
Encephalitis cytomegalovirus 45.91 27.92 11 12223 42 1734505
Polycythaemia 45.89 27.92 17 12217 348 1734199
Mycobacterium abscessus infection 45.78 27.92 12 12222 71 1734476
Acute lymphocytic leukaemia 45.45 27.92 19 12215 541 1734006
Microangiopathy 45.37 27.92 14 12220 159 1734388
Staphylococcal bacteraemia 45.31 27.92 21 12213 769 1733778
Fungal endocarditis 45.31 27.92 11 12223 45 1734502
Mycobacterium chelonae infection 45.22 27.92 12 12222 75 1734472
Systemic mycosis 45.21 27.92 14 12220 161 1734386
Pneumocystis jirovecii infection 45.20 27.92 16 12218 286 1734261
Mass excision 44.92 27.92 10 12224 25 1734522
Skin cancer 44.89 27.92 25 12209 1354 1733193
Red blood cells urine positive 44.55 27.92 13 12221 120 1734427
Skin neoplasm excision 44.55 27.92 12 12222 80 1734467
Skin toxicity 44.21 27.92 19 12215 580 1733967
Gastrointestinal disorder 44.20 27.92 40 12194 4708 1729839
Nephrogenic diabetes insipidus 44.14 27.92 15 12219 236 1734311
Coagulopathy 44.13 27.92 32 12202 2749 1731798
Purpura 44.10 27.92 27 12207 1747 1732800
Neurological decompensation 44.05 27.92 17 12217 391 1734156
Liver transplant 44.00 27.92 19 12215 587 1733960
Toxic leukoencephalopathy 43.68 27.92 11 12223 54 1734493
Mass 43.65 27.92 23 12211 1115 1733432
Arterial disorder 43.63 27.92 15 12219 245 1734302
Pulmonary mycosis 43.44 27.92 14 12220 185 1734362
Fluid retention 43.36 27.92 36 12198 3773 1730774
Cholecystectomy 43.30 27.92 18 12216 505 1734042
Hyperglycaemia 43.22 27.92 41 12193 5124 1729423
Fungal skin infection 43.12 27.92 16 12218 329 1734218
Disorientation 43.09 27.92 42 12192 5427 1729120
Tenderness 43.00 27.92 22 12212 1003 1733544
Abdominal distension 42.58 27.92 45 12189 6399 1728148
Squamous cell carcinoma of the tongue 42.56 27.92 11 12223 61 1734486
Respiratory tract infection fungal 42.32 27.92 12 12222 99 1734448
Erythrodermic psoriasis 42.06 27.92 14 12220 206 1734341
Rash papular 41.94 27.92 26 12208 1720 1732827
Vasculitis 41.80 27.92 25 12209 1550 1732997
Portal hypertension 41.74 27.92 19 12215 667 1733880
IgA nephropathy 41.72 27.92 15 12219 281 1734266
Chronic myeloid leukaemia 41.43 27.92 19 12215 679 1733868
Skin infection 41.42 27.92 21 12213 939 1733608
Pyelonephritis acute 41.39 27.92 14 12220 217 1734330
Therapeutic product effect incomplete 41.36 27.92 41 12193 5407 1729140
Tendonitis 41.33 27.92 24 12210 1409 1733138
Hepatic cancer recurrent 41.30 27.92 12 12222 109 1734438
T-cell lymphoma 41.27 27.92 14 12220 219 1734328
Tularaemia 41.17 27.92 9 12225 20 1734527
Lung lobectomy 41.17 27.92 9 12225 20 1734527
Melaena 41.03 27.92 40 12194 5170 1729377
Rotavirus infection 41.01 27.92 11 12223 72 1734475
Hepatic cirrhosis 40.90 27.92 30 12204 2623 1731924
Infection reactivation 40.82 27.92 12 12222 114 1734433
Marrow hyperplasia 40.75 27.92 13 12221 166 1734381
Nervous system disorder 40.68 27.92 29 12205 2425 1732122
Wound secretion 40.66 27.92 17 12217 484 1734063
Cardiac tamponade 40.63 27.92 21 12213 978 1733569
Diabetic nephropathy 40.49 27.92 15 12219 307 1734240
Pneumonitis 40.46 27.92 35 12199 3880 1730667
Acanthamoeba infection 40.42 27.92 10 12224 45 1734502
Aortic aneurysm 40.35 27.92 21 12213 992 1733555
Lung neoplasm malignant 40.31 27.92 32 12202 3147 1731400
Night sweats 40.29 27.92 28 12206 2248 1732299
Chest pain 40.28 27.92 79 12155 19835 1714712
Intracranial pressure increased 40.05 27.92 19 12215 734 1733813
Complications of transplanted liver 40.01 27.92 11 12223 80 1734467
Abdominal pain lower 39.62 27.92 22 12212 1185 1733362
Blood cholesterol increased 39.54 27.92 31 12203 2995 1731552
Idiopathic intracranial hypertension 39.33 27.92 13 12221 187 1734360
Blindness cortical 39.31 27.92 11 12223 86 1734461
Hodgkin's disease 39.30 27.92 19 12215 766 1733781
Renal atrophy 39.24 27.92 12 12222 132 1734415
Osteopenia 39.11 27.92 17 12217 534 1734013
Obesity 39.11 27.92 21 12213 1058 1733489
Drug level fluctuating 38.99 27.92 12 12222 135 1734412
Urinary tract obstruction 38.99 27.92 17 12217 538 1734009
Gastric cancer 38.94 27.92 21 12213 1067 1733480
Lower respiratory tract infection 38.94 27.92 34 12200 3817 1730730
Weight increased 38.90 27.92 57 12177 11300 1723247
Fatigue 38.80 27.92 140 12094 50641 1683906
Meningeal neoplasm 38.62 27.92 8 12226 12 1734535
Ureaplasma infection 38.62 27.92 8 12226 12 1734535
Nephrostomy 38.61 27.92 10 12224 56 1734491
Wound infection 38.56 27.92 20 12214 938 1733609
Drug level changed 38.52 27.92 12 12222 141 1734406
Upper respiratory tract inflammation 38.52 27.92 14 12220 271 1734276
Skin erosion 38.38 27.92 15 12219 357 1734190
Drug ineffective for unapproved indication 38.37 27.92 25 12209 1804 1732743
Arthritis 38.01 27.92 34 12200 3941 1730606
Swelling 37.85 27.92 44 12190 6952 1727595
Oligospermia 37.85 27.92 9 12225 33 1734514
Neuroendocrine carcinoma of the skin 37.84 27.92 12 12222 150 1734397
Hepatocellular injury 37.75 27.92 31 12203 3200 1731347
Herpes simplex test positive 37.61 27.92 10 12224 63 1734484
Renal cell carcinoma 37.61 27.92 23 12211 1485 1733062
Eye pain 37.39 27.92 27 12207 2304 1732243
Large intestine perforation 37.31 27.92 21 12213 1161 1733386
Oral herpes 37.20 27.92 18 12216 727 1733820
Smooth muscle cell neoplasm 37.16 27.92 8 12226 16 1734531
Chest expansion decreased 37.16 27.92 8 12226 16 1734531
Escherichia urinary tract infection 37.11 27.92 15 12219 391 1734156
Lymphadenitis 37.11 27.92 14 12220 302 1734245
Cerebral atrophy 37.11 27.92 18 12216 731 1733816
Areflexia 37.09 27.92 16 12218 493 1734054
Cytomegalovirus gastrointestinal infection 37.03 27.92 9 12225 37 1734510
Blood triglycerides increased 36.95 27.92 28 12206 2572 1731975
Post procedural complication 36.88 27.92 27 12207 2353 1732194
Dermatitis exfoliative 36.88 27.92 23 12211 1538 1733009
Orchitis 36.72 27.92 14 12220 311 1734236
Glomerulonephritis membranoproliferative 36.64 27.92 11 12223 113 1734434
Haematoma 36.25 27.92 33 12201 3912 1730635
Dysphagia 36.23 27.92 52 12182 10116 1724431
Ileus 36.22 27.92 27 12207 2419 1732128
Dermatitis atopic 36.19 27.92 13 12221 243 1734304
Abdominal mass 36.14 27.92 13 12221 244 1734303
Cytopenia 36.13 27.92 19 12215 917 1733630
Splenic abscess 36.10 27.92 10 12224 75 1734472
Corona virus infection 36.10 27.92 10 12224 75 1734472
Keratitis 36.03 27.92 14 12220 328 1734219
Pyelonephritis chronic 35.93 27.92 8 12226 20 1734527
Peripheral T-cell lymphoma unspecified 35.72 27.92 11 12223 124 1734423
Pulmonary embolism 35.60 27.92 59 12175 13000 1721547
Cognitive disorder 35.52 27.92 34 12200 4296 1730251
Blood potassium increased 35.41 27.92 27 12207 2503 1732044
Urinary tract infection enterococcal 35.41 27.92 11 12223 128 1734419
Keratoacanthoma 35.41 27.92 11 12223 128 1734419
Cystitis 35.29 27.92 21 12213 1290 1733257
Endocarditis 35.13 27.92 19 12215 971 1733576
Gouty tophus 35.12 27.92 9 12225 48 1734499
Scleroderma 35.09 27.92 13 12221 266 1734281
Glomerulonephritis proliferative 35.00 27.92 10 12224 85 1734462
Meningitis tuberculous 35.00 27.92 10 12224 85 1734462
Back pain 34.93 27.92 67 12167 16546 1718001
Graft complication 34.80 27.92 10 12224 87 1734460
Pulmonary cavitation 34.73 27.92 11 12223 137 1734410
Drug level below therapeutic 34.66 27.92 15 12219 466 1734081
Hyperplasia 34.58 27.92 11 12223 139 1734408
Muscle atrophy 34.42 27.92 20 12214 1175 1733372
Vision blurred 34.39 27.92 46 12188 8377 1726170
Renal infarct 34.22 27.92 13 12221 286 1734261
Urinoma 34.16 27.92 8 12226 27 1734520
Hydrocephalus 34.13 27.92 18 12216 874 1733673
Polypectomy 34.11 27.92 10 12224 94 1734453
Influenza 34.03 27.92 41 12193 6726 1727821
Creatinine renal clearance decreased 34.01 27.92 17 12217 737 1733810
Enterocolitis 33.96 27.92 18 12216 883 1733664
Shock haemorrhagic 33.80 27.92 21 12213 1395 1733152
Transitional cell carcinoma 33.76 27.92 13 12221 297 1734250
Still's disease 33.67 27.92 9 12225 58 1734489
Viraemia 33.62 27.92 11 12223 153 1734394
Pneumonia aspiration 33.42 27.92 36 12198 5230 1729317
Hypertensive encephalopathy 33.38 27.92 10 12224 102 1734445
Red blood cell sedimentation rate increased 33.37 27.92 19 12215 1074 1733473
Necrotising fasciitis 33.37 27.92 16 12218 633 1733914
Arteriosclerosis 33.35 27.92 23 12211 1824 1732723
Myoclonus 33.24 27.92 25 12209 2270 1732277
Anaplastic large cell lymphoma T- and null-cell types 33.16 27.92 9 12225 62 1734485
Forced expiratory volume decreased 32.99 27.92 14 12220 414 1734133
Nystagmus 32.90 27.92 18 12216 941 1733606
Removal of renal transplant 32.86 27.92 7 12227 13 1734534
Arrhythmia 32.82 27.92 38 12196 5978 1728569
Neutrophil count increased 32.66 27.92 26 12208 2567 1731980
Pharyngitis 32.50 27.92 19 12215 1129 1733418
Bronchitis 32.50 27.92 36 12198 5396 1729151
Endocarditis bacterial 32.37 27.92 11 12223 173 1734374
Cat scratch disease 32.19 27.92 7 12227 15 1734532
Mycobacterium kansasii infection 32.16 27.92 8 12226 37 1734510
Trichodysplasia spinulosa 32.16 27.92 8 12226 37 1734510
Myasthenic syndrome 32.09 27.92 9 12225 71 1734476
Blood immunoglobulin G decreased 32.06 27.92 10 12224 118 1734429
Oesophageal carcinoma 32.00 27.92 16 12218 694 1733853
Folliculitis 31.96 27.92 16 12218 696 1733851
Circulatory collapse 31.85 27.92 29 12205 3438 1731109
Pneumonia streptococcal 31.75 27.92 11 12223 184 1734363
Steroid diabetes 31.66 27.92 9 12225 75 1734472
Cardiac failure acute 31.59 27.92 19 12215 1190 1733357
Endoscopic retrograde cholangiopancreatography 31.58 27.92 7 12227 17 1734530
Scar 31.57 27.92 17 12217 861 1733686
Pyogenic granuloma 31.55 27.92 9 12225 76 1734471
Tracheostomy 31.53 27.92 11 12223 188 1734359
Visceral leishmaniasis 31.39 27.92 10 12224 127 1734420
Abdominal tenderness 31.39 27.92 15 12219 589 1733958
Epidermodysplasia verruciformis 31.39 27.92 6 12228 4 1734543
Oxygen saturation decreased 31.21 27.92 36 12198 5639 1728908
Stenotrophomonas infection 31.21 27.92 11 12223 194 1734353
Device related sepsis 31.20 27.92 13 12221 367 1734180
Urinary tract infection bacterial 31.05 27.92 11 12223 197 1734350
Epstein-Barr virus test positive 31.04 27.92 10 12224 132 1734415
Iridocyclitis 31.00 27.92 13 12221 373 1734174
Neutrophil count decreased 30.83 27.92 37 12197 6044 1728503
Varicella zoster virus infection 30.75 27.92 11 12223 203 1734344
Fungaemia 30.69 27.92 12 12222 286 1734261
Retinitis 30.66 27.92 9 12225 85 1734462
Mycoplasma infection 30.56 27.92 9 12225 86 1734461
Lethargy 30.50 27.92 40 12194 7144 1727403
Parvovirus B19 infection 30.38 27.92 9 12225 88 1734459
Cytomegalovirus syndrome 30.30 27.92 6 12228 6 1734541
Ureteric anastomosis complication 30.30 27.92 6 12228 6 1734541
Rales 30.28 27.92 17 12217 935 1733612
Urine analysis abnormal 30.27 27.92 12 12222 297 1734250
Activated partial thromboplastin time shortened 30.20 27.92 9 12225 90 1734457
H1N1 influenza 30.16 27.92 11 12223 215 1734332
Cerebellar syndrome 30.14 27.92 14 12220 515 1734032
Skin disorder 30.08 27.92 23 12211 2141 1732406
Blood pressure decreased 30.06 27.92 41 12193 7605 1726942
Osteomyelitis fungal 30.03 27.92 7 12227 23 1734524
Lepromatous leprosy 30.03 27.92 7 12227 23 1734524
Thoracotomy 29.80 27.92 7 12227 24 1734523
Haemorrhagic diathesis 29.65 27.92 14 12220 535 1734012
Angiopathy 29.64 27.92 15 12219 668 1733879
Abdominal abscess 29.64 27.92 15 12219 668 1733879
Lactobacillus infection 29.58 27.92 7 12227 25 1734522
Superficial spreading melanoma stage unspecified 29.49 27.92 8 12226 55 1734492
Complications of transplanted lung 29.37 27.92 7 12227 26 1734521
Neoplasm 29.36 27.92 16 12218 830 1733717
Purulent discharge 29.17 27.92 14 12220 555 1733992
Bile duct obstruction 29.14 27.92 13 12221 435 1734112
Myositis 29.03 27.92 20 12214 1583 1732964
Renal cyst 28.88 27.92 17 12217 1023 1733524
Incisional drainage 28.88 27.92 8 12226 60 1734487
Fibrosis 28.86 27.92 13 12221 445 1734102
Prothrombin time prolonged 28.83 27.92 20 12214 1601 1732946
Ureteral stent insertion 28.76 27.92 7 12227 29 1734518
Abscess drainage 28.72 27.92 9 12225 108 1734439
Large intestinal ulcer 28.69 27.92 12 12222 342 1734205
Immune thrombocytopenic purpura 28.68 27.92 19 12215 1410 1733137
Impaired gastric emptying 28.62 27.92 13 12221 454 1734093
Thyroid cancer 28.59 27.92 12 12222 345 1734202
Scopulariopsis infection 28.57 27.92 6 12228 10 1734537
Disseminated varicella zoster vaccine virus infection 28.57 27.92 6 12228 10 1734537
Acid fast bacilli infection 28.57 27.92 7 12227 30 1734517
Colon cancer 28.55 27.92 21 12213 1843 1732704
Mental disorder 28.54 27.92 25 12209 2818 1731729
Hypomagnesaemia 28.51 27.92 22 12212 2076 1732471
Hallucination, visual 28.47 27.92 24 12210 2568 1731979
Demyelinating polyneuropathy 28.42 27.92 11 12223 255 1734292
Hypoproteinaemia 28.40 27.92 12 12222 351 1734196
Chest discomfort 28.35 27.92 39 12195 7292 1727255
Laser therapy 28.21 27.92 6 12228 11 1734536
Demyelination 28.12 27.92 14 12220 602 1733945

Pharmacologic Action:

SourceCodeDescription
ATC L04AD01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Calcineurin inhibitors
ATC S01XA18 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA EPC N0000175457 Calcineurin Inhibitor Immunosuppressant
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
FDA MoA N0000185503 P-Glycoprotein Inhibitors
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D065095 Calcineurin Inhibitors
MeSH PA D003879 Dermatologic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:49167 anti-asthmatic drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Tear film insufficiency indication 46152009
Rheumatoid arthritis indication 69896004 DOID:7148
Keratoconjunctivitis sicca indication 302896008 DOID:12895
Prevention of Cardiac Transplant Rejection indication
Prevention of Liver Transplant Rejection indication
Severe Recalcitrant Psoriasis indication
Prevention of Kidney Transplant Rejection indication
Graft-versus-host disease off-label use 234646005
Prevention of Lung Transplant Rejection off-label use
Pure Red Cell Aplasia associated with Chronic Lymphocytic Leukemia off-label use
Prevention of Graft Versus Host Disease off-label use
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Hyperbilirubinemia contraindication 14783006 DOID:2741
Metabolic acidosis, normal anion gap, acidifying salts contraindication 18104000
Hyperuricemia contraindication 35885006 DOID:1920
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Benign intracranial hypertension contraindication 68267002 DOID:11459
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Disorder of brain contraindication 81308009 DOID:936
Kidney disease contraindication 90708001 DOID:557
Neoplasm contraindication 108369006
Malignant lymphoma contraindication 118600007 DOID:0060058
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Toxic nephropathy contraindication 236514003
Hypertriglyceridemia contraindication 302870006
Primary malignant neoplasm contraindication 372087000
Breastfeeding (mother) contraindication 413712001
Hypertensive urgency contraindication 443482000
Cyclosporine Toxicity contraindication
BK Polyomavirus Reactivation Nephropathy contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.05% RESTASIS ALLERGAN N050790 Dec. 23, 2002 RX EMULSION OPHTHALMIC 8633162 Aug. 27, 2024 INCREASE TEAR PRODUCTION TO TREAT PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.05% RESTASIS MULTIDOSE ALLERGAN N050790 Oct. 27, 2016 RX EMULSION OPHTHALMIC 8633162 Aug. 27, 2024 INCREASE TEAR PRODUCTION TO TREAT PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.05% RESTASIS ALLERGAN N050790 Dec. 23, 2002 RX EMULSION OPHTHALMIC 8648048 Aug. 27, 2024 INCREASE TEAR PRODUCTION IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.05% RESTASIS MULTIDOSE ALLERGAN N050790 Oct. 27, 2016 RX EMULSION OPHTHALMIC 8648048 Aug. 27, 2024 INCREASE TEAR PRODUCTION IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.05% RESTASIS ALLERGAN N050790 Dec. 23, 2002 RX EMULSION OPHTHALMIC 9248191 Aug. 27, 2024 INCREASE TEAR PRODUCTION TO TREAT PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.05% RESTASIS MULTIDOSE ALLERGAN N050790 Oct. 27, 2016 RX EMULSION OPHTHALMIC 9248191 Aug. 27, 2024 INCREASE TEAR PRODUCTION TO TREAT PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.09% CEQUA SUN PHARMA GLOBAL N210913 Aug. 14, 2018 RX SOLUTION OPHTHALMIC 8980839 Aug. 23, 2033 INCREASE TEAR PRODUCTION IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.09% CEQUA SUN PHARMA GLOBAL N210913 Aug. 14, 2018 RX SOLUTION OPHTHALMIC 9937225 Aug. 23, 2033 INCREASE TEAR PRODUCTION IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Peptidyl-prolyl cis-trans isomerase A Enzyme MODULATOR IC50 8.05 WOMBAT-PK CHEMBL
Dihydroorotate dehydrogenase (quinone), mitochondrial Enzyme IC50 6.70 WOMBAT-PK
Peptidyl-prolyl cis-trans isomerase FKBP1A Enzyme IC50 7.80 WOMBAT-PK
Substance-K receptor GPCR Ki 5.86 DRUG MATRIX
Multidrug resistance protein 1 Transporter EC50 6.30 WOMBAT-PK
Cytochrome P450 3A4 Enzyme Ki 5.31 WOMBAT-PK
Sodium/bile acid cotransporter Transporter INHIBITOR IC50 6 IUPHAR
Solute carrier organic anion transporter family member 1B3 Transporter INHIBITOR IC50 6.10 IUPHAR
fMet-Leu-Phe receptor GPCR ANTAGONIST EC50 6.30 IUPHAR
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Enzyme Kd 8.40 CHEMBL
Canalicular multispecific organic anion transporter 1 Transporter IC50 4.87 CHEMBL
Multidrug resistance-associated protein 1 Transporter IC50 5.57 CHEMBL
Peptidyl-prolyl cis-trans isomerase D Enzyme Ki 8.15 CHEMBL
Peptidyl-prolyl cis-trans isomerase B Enzyme Kd 8.01 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP1B Enzyme Ki 8.22 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP4 Enzyme IC50 7.80 CHEMBL
ATP-binding cassette sub-family G member 2 Transporter IC50 4.20 CHEMBL
Bile salt export pump Transporter IC50 6.30 CHEMBL
Solute carrier organic anion transporter family member 1B1 Transporter INHIBITOR Ki 7.29 IUPHAR
Reverse transcriptase/RNaseH Enzyme IC50 6.34 CHEMBL
Bile salt export pump Unclassified IC50 6.22 CHEMBL

External reference:

IDSource
4018761 VUID
N0000147064 NUI
C0010592 UMLSCUI
D00184 KEGG_DRUG
80906007 SNOMEDCT_US
3008 RXNORM
4521 MMSL
d00079 MMSL
4018761 VANDF
31626 MMSL
72396 MMSL
003420 NDDF
387467008 SNOMEDCT_US
83HN0GTJ6D UNII
5086 INN_ID
CHEMBL160 ChEMBL_ID
DB00091 DRUGBANK_ID
CHEBI:4031 CHEBI
1024 IUPHAR_LIGAND_ID
D016572 MESH_DESCRIPTOR_UI
5284373 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Restasis MultiDose HUMAN PRESCRIPTION DRUG LABEL 1 0023-5301 EMULSION 0.50 mg OPHTHALMIC NDA 15 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 0023-9163 EMULSION 0.50 mg OPHTHALMIC NDA 14 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-0541 CAPSULE 50 mg ORAL ANDA 13 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-3108 CAPSULE 25 mg ORAL ANDA 13 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-3109 CAPSULE 100 mg ORAL ANDA 13 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-6463 CAPSULE 25 mg ORAL ANDA 13 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-6479 CAPSULE 100 mg ORAL ANDA 13 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-7269 SOLUTION 100 mg ORAL ANDA 13 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0109 INJECTION 50 mg INTRAVENOUS NDA 20 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0110 SOLUTION 100 mg ORAL NDA 20 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0240 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 20 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0241 CAPSULE, LIQUID FILLED 100 mg ORAL NDA 20 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0246 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 20 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0248 CAPSULE, LIQUID FILLED 100 mg ORAL NDA 20 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0274 SOLUTION 100 mg ORAL NDA 20 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5740 CAPSULE, LIQUID FILLED 25 mg ORAL ANDA 12 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5741 CAPSULE, LIQUID FILLED 50 mg ORAL ANDA 12 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5742 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 12 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 0172-7313 SOLUTION 100 mg ORAL ANDA 12 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 0517-0866 INJECTION, SOLUTION 50 mg INTRAVENOUS UNAPPROVED DRUG FOR USE IN DRUG SHORTAGE 14 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 0574-0866 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 13 sections
CEQUA HUMAN PRESCRIPTION DRUG LABEL 1 47335-506 SOLUTION/ DROPS 0.00 g OPHTHALMIC NDA 14 sections
CEQUA HUMAN PRESCRIPTION DRUG LABEL 1 47335-507 SOLUTION/ DROPS 0.00 mg OPHTHALMIC NDA 14 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 50090-1242 EMULSION 0.50 mg OPHTHALMIC NDA 14 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 50090-4476 EMULSION 0.50 mg OPHTHALMIC NDA 15 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 51862-458 CAPSULE, LIQUID FILLED 25 mg ORAL ANDA 14 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 51862-460 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 14 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 54868-4793 EMULSION 0.50 mg OPHTHALMIC NDA 11 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 54868-5522 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 12 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 54868-6232 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 12 sections