ciclosporin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
ciclosporin derivatives 760 59865-13-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • neoral
  • ciclosporin
  • cyclosporine
  • cyclosporin
  • ciclosporine
  • cyclosporin A
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
  • Molecular weight: 1202.64
  • Formula: C62H111N11O12
  • CLOGP: 12
  • LIPINSKI: 3
  • HAC: 23
  • HDO: 5
  • TPSA: 278.80
  • ALOGS: -5.10
  • ROTB: 15
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.25 g O
0.25 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0.10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.66 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 30 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.07 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 21, 2020 PMDA Novartis Pharma K.K.
Nov. 14, 1983 FDA NOVARTIS
May 19, 2015 EMA Santen Oy

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 1647.08 9.61 868 153356 20084 63314714
Eye irritation 1527.78 9.61 839 153385 21132 63313666
Transplant dysfunction 1490.07 9.61 528 153696 4344 63330454
Transplant rejection 1426.60 9.61 638 153586 10142 63324656
Graft versus host disease 1003.93 9.61 434 153790 6329 63328469
Acute graft versus host disease 904.45 9.61 357 153867 4071 63330727
Product use in unapproved indication 820.51 9.61 1520 152704 177560 63157238
Chronic graft versus host disease 791.02 9.61 294 153930 2808 63331990
Acute graft versus host disease in skin 717.98 9.61 282 153942 3170 63331628
Ovarian cyst 690.48 9.61 449 153775 15496 63319302
Epstein-Barr virus infection 679.56 9.61 350 153874 7700 63327098
Graft versus host disease in skin 624.24 9.61 243 153981 2662 63332136
Blood iron abnormal 589.24 9.61 253 153971 3623 63331175
Graft versus host disease in gastrointestinal tract 584.76 9.61 239 153985 3002 63331796
Post transplant lymphoproliferative disorder 565.80 9.61 266 153958 4765 63330033
Acne 538.11 9.61 449 153775 22844 63311954
Posterior reversible encephalopathy syndrome 487.27 9.61 375 153849 16970 63317828
Kidney transplant rejection 487.04 9.61 228 153996 4043 63330755
Thrombotic microangiopathy 451.36 9.61 295 153929 10266 63324532
Adenovirus infection 436.38 9.61 200 154024 3371 63331427
Acute graft versus host disease in intestine 414.04 9.61 157 154067 1592 63333206
Renal impairment 414.02 9.61 758 153466 87597 63247201
Foreign body sensation in eyes 410.76 9.61 167 154057 2067 63332731
Pemphigus 398.93 9.61 10 154214 183716 63151082
Haemophagocytic lymphohistiocytosis 378.13 9.61 265 153959 10362 63324436
Eye pain 373.91 9.61 436 153788 33418 63301380
Glossodynia 359.77 9.61 18 154206 178858 63155940
Cystitis haemorrhagic 352.99 9.61 181 154043 3942 63330856
Blood parathyroid hormone decreased 343.36 9.61 242 153982 9549 63325249
Completed suicide 332.33 9.61 4 154220 145669 63189129
Panniculitis 330.43 9.61 251 153973 11134 63323664
Blood creatinine increased 326.87 9.61 684 153540 87160 63247638
Cytomegalovirus viraemia 325.78 9.61 191 154033 5458 63329340
BK virus infection 325.06 9.61 159 154065 3120 63331678
Multiple organ dysfunction syndrome 324.78 9.61 532 153692 56220 63278578
Ocular hyperaemia 324.12 9.61 351 153873 24793 63310005
Hand deformity 320.80 9.61 16 154208 159441 63175357
Nephropathy toxic 313.33 9.61 226 153998 9253 63325545
Granuloma skin 308.62 9.61 214 154010 8223 63326575
Cytomegalovirus infection reactivation 288.21 9.61 156 154068 3807 63330991
Skin necrosis 285.65 9.61 251 153973 13699 63321099
Systemic lupus erythematosus 267.64 9.61 87 154137 208831 63125967
Immunosuppressant drug level increased 261.21 9.61 142 154082 3496 63331302
Aspergillus infection 256.24 9.61 188 154036 7905 63326893
Basal cell carcinoma 250.08 9.61 324 153900 27667 63307131
Fatigue 248.76 9.61 1213 153011 886815 62447983
Drug ineffective 248.53 9.61 3729 150495 1041036 62293762
Swelling 246.91 9.61 185 154039 275193 63059605
Wound 243.44 9.61 50 154174 163213 63171585
Acute graft versus host disease in liver 237.03 9.61 81 154143 590 63334208
Bronchopulmonary aspergillosis 217.30 9.61 175 154049 8460 63326338
Abdominal discomfort 211.57 9.61 282 153942 320603 63014195
Instillation site pain 209.85 9.61 80 154144 824 63333974
Pericarditis 209.70 9.61 34 154190 131545 63203253
Rheumatoid nodule 208.11 9.61 232 153992 16923 63317875
Product container issue 205.30 9.61 96 154128 1697 63333101
Fall 195.63 9.61 413 153811 391921 62942877
Ulcer 193.47 9.61 276 153948 25831 63308967
Demyelination 192.98 9.61 149 154075 6771 63328027
Chronic graft versus host disease in skin 190.62 9.61 71 154153 682 63334116
Hypercalcaemia 186.19 9.61 283 153941 28039 63306759
Duodenal ulcer perforation 184.60 9.61 6 154218 87203 63247595
Anti-cyclic citrullinated peptide antibody positive 180.83 9.61 32 154192 116180 63218618
Scleral hyperaemia 179.41 9.61 54 154170 245 63334553
Epstein-Barr virus associated lymphoproliferative disorder 179.28 9.61 89 154135 1805 63332993
Helicobacter infection 178.34 9.61 12 154212 92773 63242025
Nausea 174.58 9.61 1289 152935 853182 62481616
Skin ulcer 170.40 9.61 344 153880 42701 63292097
Therapeutic response decreased 167.82 9.61 424 153800 61101 63273697
Graft versus host disease in liver 166.51 9.61 62 154162 595 63334203
Red blood cell sedimentation rate increased 165.27 9.61 344 153880 43638 63291160
SLE arthritis 164.34 9.61 62 154162 619 63334179
Drug eruption 164.11 9.61 269 153955 28425 63306373
Dizziness 162.64 9.61 520 153704 429405 62905393
Cytomegalovirus test positive 160.87 9.61 97 154127 2921 63331877
Dyspnoea 158.27 9.61 951 153273 660362 62674436
Complications of transplanted kidney 156.51 9.61 89 154135 2397 63332401
Liver transplant rejection 155.60 9.61 74 154150 1361 63333437
Smooth muscle cell neoplasm 155.07 9.61 63 154161 778 63334020
Liver function test abnormal 152.82 9.61 352 153872 47829 63286969
Pseudomonas infection 152.36 9.61 161 154063 11052 63323746
Discomfort 151.76 9.61 111 154113 167263 63167535
Intentional overdose 150.49 9.61 7 154217 74145 63260653
Human herpesvirus 6 infection 149.81 9.61 92 154132 2865 63331933
Lacrimation increased 149.77 9.61 216 154008 20415 63314383
Pain 148.82 9.61 1122 153102 739506 62595292
Eye discharge 148.60 9.61 121 154103 5942 63328856
Psoriasis 148.42 9.61 507 153717 86450 63248348
Obliterative bronchiolitis 148.26 9.61 81 154143 2014 63332784
Gingival hypertrophy 147.82 9.61 75 154149 1596 63333202
Epstein-Barr viraemia 143.94 9.61 63 154161 947 63333851
Muscle injury 143.91 9.61 3 154221 65342 63269456
Enthesopathy 141.40 9.61 137 154087 8477 63326321
Viraemia 140.06 9.61 67 154157 1249 63333549
Death 137.24 9.61 459 153765 373922 62960876
Complications of bone marrow transplant 136.25 9.61 49 154175 422 63334376
Drug abuse 134.74 9.61 11 154213 72507 63262291
Epstein-Barr virus infection reactivation 134.30 9.61 56 154168 742 63334056
Eye pruritus 133.38 9.61 194 154030 18477 63316321
Confusional state 130.53 9.61 234 153990 236146 63098652
Constipation 130.30 9.61 216 154008 224727 63110071
Treatment failure 129.81 9.61 878 153346 198165 63136633
Hypotension 129.10 9.61 295 153929 272309 63062489
Chronic allograft nephropathy 128.99 9.61 53 154171 675 63334123
Impaired gastric emptying 127.50 9.61 141 154083 10191 63324607
Venoocclusive liver disease 125.95 9.61 100 154124 4735 63330063
Cytomegalovirus colitis 125.82 9.61 76 154148 2296 63332502
Elbow deformity 125.34 9.61 65 154159 1450 63333348
Lung transplant rejection 123.02 9.61 55 154169 872 63333926
Venoocclusive disease 122.41 9.61 71 154153 1987 63332811
Inflammation 121.88 9.61 458 153766 81815 63252983
C-reactive protein increased 121.56 9.61 504 153720 94203 63240595
Alveolar proteinosis 117.08 9.61 41 154183 324 63334474
Aplastic anaemia 117.07 9.61 130 154094 9439 63325359
Folliculitis 117 9.61 16 154208 70301 63264497
Irritable bowel syndrome 115.26 9.61 29 154195 82383 63252415
Anxiety 112.49 9.61 224 154000 217317 63117481
Pneumonia cytomegaloviral 112.46 9.61 69 154155 2145 63332653
Asthenia 112.01 9.61 515 153709 383089 62951709
Immunosuppressant drug level decreased 111.62 9.61 52 154172 911 63333887
Transplant failure 111.39 9.61 61 154163 1524 63333274
Chronic graft versus host disease in liver 110.53 9.61 37 154187 251 63334547
Off label use 109.55 9.61 2269 151955 672193 62662605
Vomiting 107.84 9.61 857 153367 558760 62776038
Hypogammaglobulinaemia 106.70 9.61 108 154116 7047 63327751
Aspartate aminotransferase increased 106.26 9.61 468 153756 89809 63244989
Alanine aminotransferase increased 105.96 9.61 516 153708 103254 63231544
Lymphocele 103.73 9.61 47 154177 770 63334028
Heart transplant rejection 102.97 9.61 43 154181 572 63334226
Drug intolerance 102.33 9.61 1173 153051 307488 63027310
Lymphoproliferative disorder 100.75 9.61 74 154150 3116 63331682
Herpes zoster 99.73 9.61 431 153793 82031 63252767
Red blood cell sedimentation rate 98.69 9.61 87 154137 4767 63330031
Arthropathy 97.98 9.61 271 153953 234521 63100277
Soft tissue disorder 97.47 9.61 83 154141 4339 63330459
Gastrooesophageal reflux disease 96.75 9.61 56 154168 95583 63239215
Ankylosing spondylitis 96.29 9.61 123 154101 10351 63324447
Mucormycosis 96.13 9.61 69 154155 2802 63331996
Electrocardiogram QT prolonged 95.67 9.61 15 154209 59515 63275283
Tongue disorder 95.31 9.61 123 154101 10457 63324341
Vision blurred 95.21 9.61 459 153765 91465 63243333
Sepsis 93.61 9.61 665 153559 152458 63182340
Somnolence 93.20 9.61 183 154041 178502 63156296
Leukopenia 92.72 9.61 403 153821 76887 63257911
Tenosynovitis 92.29 9.61 139 154085 13656 63321142
Weight increased 91.89 9.61 325 153899 260467 63074331
Proteinuria 91.77 9.61 166 154058 18979 63315819
Oral administration complication 91.71 9.61 26 154198 91 63334707
Skin plaque 91.56 9.61 107 154117 8213 63326585
Impaired healing 90.34 9.61 70 154154 102472 63232326
Lower respiratory tract infection 89.38 9.61 114 154110 132193 63202605
Pneumocystis jirovecii pneumonia 89.29 9.61 153 154071 16761 63318037
Viral haemorrhagic cystitis 88.72 9.61 43 154181 826 63333972
Drug resistance 88.05 9.61 181 154043 22752 63312046
Rheumatic fever 87.70 9.61 4 154220 43107 63291691
Dehydration 87.46 9.61 181 154043 173173 63161625
Hepatic enzyme increased 86.30 9.61 231 153993 202097 63132701
Cutaneous T-cell lymphoma 85.79 9.61 49 154175 1331 63333467
Leukaemia recurrent 84.50 9.61 48 154176 1290 63333508
Hepatosplenic T-cell lymphoma 83.95 9.61 37 154187 566 63334232
Rheumatoid factor positive 83.15 9.61 51 154173 84355 63250443
Drug ineffective for unapproved indication 82.89 9.61 225 153999 33838 63300960
Diabetes mellitus 82.06 9.61 310 153914 55500 63279298
Pathogen resistance 81.87 9.61 89 154135 6309 63328489
Erythema of eyelid 81.30 9.61 57 154167 2229 63332569
Chorioretinopathy 81.12 9.61 40 154184 799 63333999
Type 2 diabetes mellitus 80.99 9.61 27 154197 63841 63270957
Abdominal pain upper 79.77 9.61 247 153977 206197 63128601
Renal transplant failure 78.69 9.61 38 154186 724 63334074
Cerebrovascular accident 78.36 9.61 88 154136 107936 63226862
Focal segmental glomerulosclerosis 77.77 9.61 47 154177 1421 63333377
Hirsutism 77.37 9.61 46 154178 1349 63333449
Syncope 77.37 9.61 103 154121 117282 63217516
Diffuse large B-cell lymphoma 76.68 9.61 88 154136 6624 63328174
Hypertrichosis 74.50 9.61 42 154182 1112 63333686
Swollen joint count increased 74.48 9.61 3 154221 36051 63298747
Nasopharyngitis 73.73 9.61 342 153882 253915 63080883
Contusion 73.72 9.61 159 154065 149885 63184913
Suicide attempt 73.41 9.61 28 154196 60890 63273908
Disease recurrence 73.12 9.61 190 154034 27840 63306958
Aplasia pure red cell 72.96 9.61 71 154153 4416 63330382
Nocardiosis 71.98 9.61 50 154174 1926 63332872
Hyperhidrosis 71.70 9.61 94 154130 107742 63227056
Decreased appetite 71.43 9.61 340 153884 250712 63084086
Septic shock 71.38 9.61 336 153888 66293 63268505
Wheezing 70.30 9.61 77 154147 95518 63239280
Hypokalaemia 69.52 9.61 90 154134 103714 63231084
Hair follicle tumour benign 68.37 9.61 29 154195 402 63334396
Graft versus host disease in lung 68.33 9.61 28 154196 354 63334444
Encephalitis viral 68.24 9.61 46 154178 1686 63333112
Polyomavirus viraemia 68.02 9.61 34 154190 700 63334098
Graft complication 67.97 9.61 25 154199 231 63334567
Malignant neoplasm progression 67.46 9.61 60 154164 82061 63252737
Back pain 67.09 9.61 372 153852 263773 63071025
Klebsiella infection 67.07 9.61 93 154131 8473 63326325
Glomerulosclerosis 66.75 9.61 28 154196 377 63334421
Depression 66.45 9.61 249 153975 196243 63138555
Fear of injection 65.65 9.61 84 154140 7080 63327718
Paraesthesia 65.57 9.61 181 154043 156785 63178013
Rash pruritic 64.37 9.61 302 153922 59497 63275301
Bone marrow failure 63.93 9.61 186 154038 29104 63305694
Stem cell transplant 63.80 9.61 45 154179 1777 63333021
Herpes simplex 63.57 9.61 89 154135 8182 63326616
Hyponatraemia 63.30 9.61 109 154115 111791 63223007
Epstein-Barr virus associated lymphoma 63.25 9.61 29 154195 489 63334309
Malaise 63.08 9.61 676 153548 415278 62919520
Device expulsion 62.96 9.61 6 154218 34916 63299882
Palpitations 61.85 9.61 112 154112 112658 63222140
Blister 61.76 9.61 140 154084 129674 63205124
Muscle spasms 61.60 9.61 185 154039 155965 63178833
Loss of personal independence in daily activities 61.45 9.61 426 153798 96864 63237934
Skin lesion 61.30 9.61 189 154035 30532 63304266
Bradycardia 60.76 9.61 53 154171 73174 63261624
Headache 60.58 9.61 1129 153095 632112 62702686
Mucosal inflammation 60.38 9.61 250 153974 46678 63288120
Cognitive disorder 60.37 9.61 30 154194 55785 63279013
Knee arthroplasty 60.36 9.61 28 154196 54178 63280620
Varicella zoster virus infection 60.35 9.61 51 154173 2638 63332160
Drug tolerance decreased 60.24 9.61 132 154092 17341 63317457
Chronic graft versus host disease in eye 59.90 9.61 19 154205 106 63334692
Squamous cell carcinoma 59.20 9.61 88 154136 8544 63326254
Diarrhoea 58.76 9.61 1308 152916 714058 62620740
Pneumomediastinum 58.65 9.61 39 154185 1397 63333401
Scedosporium infection 57.91 9.61 28 154196 535 63334263
Hypoaesthesia 57.84 9.61 212 154012 168181 63166617
General physical health deterioration 57.71 9.61 272 153952 201130 63133668
Superficial injury of eye 57.67 9.61 22 154202 227 63334571
Alanine aminotransferase abnormal 56.50 9.61 62 154162 4442 63330356
Injury 56.09 9.61 57 154167 73190 63261608
Blood bilirubin increased 55.17 9.61 207 154017 36933 63297865
Erythema 55.06 9.61 661 153563 175090 63159708
Blood lactate dehydrogenase increased 54.55 9.61 151 154073 22965 63311833
Toxicity to various agents 54.50 9.61 364 153860 246886 63087912
Infusion related reaction 54.35 9.61 361 153863 245160 63089638
Therapeutic product effect variable 54.30 9.61 35 154189 1188 63333610
C-reactive protein abnormal 54.24 9.61 239 153985 45857 63288941
Cardio-respiratory arrest 53.99 9.61 40 154184 59919 63274879
Kidney fibrosis 53.54 9.61 41 154183 1840 63332958
Psoriatic arthropathy 53.31 9.61 393 153831 91127 63243671
Cardiac failure congestive 53.23 9.61 89 154135 92344 63242454
Clear cell renal cell carcinoma 52.75 9.61 37 154187 1448 63333350
Balance disorder 52.70 9.61 77 154147 84345 63250453
Hepatic function abnormal 52.70 9.61 204 154020 36938 63297860
Disseminated intravascular coagulation 52.66 9.61 132 154092 18919 63315879
Neurotoxicity 52.61 9.61 123 154101 16867 63317931
Asthma 52.59 9.61 148 154076 127413 63207385
Chronic graft versus host disease oral 52.33 9.61 18 154206 134 63334664
Tendonitis 52.23 9.61 134 154090 19481 63315317
Prescribed overdose 51.82 9.61 10 154214 34143 63300655
Lupus vasculitis 51.68 9.61 26 154198 543 63334255
Pancytopenia 51.29 9.61 407 153817 96526 63238272
Chronic obstructive pulmonary disease 51.25 9.61 46 154178 62640 63272158
Lactic acidosis 50.66 9.61 15 154209 38272 63296526
Kaposi's sarcoma 50.57 9.61 18 154206 150 63334648
Eyelid oedema 50.40 9.61 91 154133 10388 63324410
Pneumonia fungal 50.05 9.61 64 154160 5391 63329407
Bronchiolitis obliterans syndrome 49.61 9.61 17 154207 125 63334673
Abnormal sensation in eye 49.51 9.61 38 154186 1711 63333087
Pneumonia adenoviral 49.26 9.61 17 154207 128 63334670
Product delivery mechanism issue 49.14 9.61 22 154202 350 63334448
Laryngitis fungal 49.03 9.61 17 154207 130 63334668
Injection site pain 48.91 9.61 157 154067 129643 63205155
Staphylococcal infection 48.61 9.61 214 154010 41042 63293756
Fusarium infection 48.57 9.61 26 154198 620 63334178
Red blood cell schistocytes present 48.10 9.61 20 154204 263 63334535
Oedema peripheral 48.03 9.61 267 153957 189244 63145554
Hypoglycaemia 48.01 9.61 45 154179 60020 63274778
Therapeutic product effect incomplete 47.69 9.61 489 153735 124567 63210231
Cystitis viral 47.52 9.61 17 154207 144 63334654
Leukoencephalopathy 47.31 9.61 56 154168 4357 63330441
Haemolytic uraemic syndrome 47.20 9.61 43 154181 2460 63332338
International normalised ratio increased 47.20 9.61 27 154197 46398 63288400
Microsporidia infection 47.17 9.61 20 154204 277 63334521
Bacterial sepsis 47.09 9.61 53 154171 3905 63330893
Injection site erythema 47.05 9.61 81 154143 83093 63251705
Enterococcal infection 46.80 9.61 75 154149 7773 63327025
Multiple sclerosis relapse 46.76 9.61 30 154194 48448 63286350
Renal failure 46.76 9.61 464 153760 117188 63217610
Memory impairment 46.74 9.61 116 154108 104142 63230656
Serum ferritin increased 46.74 9.61 66 154158 6116 63328682
Flushing 46.37 9.61 69 154155 75018 63259780
Orthostatic hypotension 46.34 9.61 15 154209 36145 63298653
Disseminated cryptococcosis 45.85 9.61 22 154202 413 63334385
Acute myeloid leukaemia recurrent 45.37 9.61 35 154189 1588 63333210
Pneumonia viral 44.92 9.61 74 154150 7848 63326950
Medication error 44.40 9.61 37 154187 52247 63282551
Cytomegalovirus chorioretinitis 44.39 9.61 36 154188 1757 63333041
Nephrotic syndrome 44.35 9.61 61 154163 5515 63329283
Renal tubular atrophy 44.12 9.61 26 154198 750 63334048
Disseminated tuberculosis 44.08 9.61 44 154180 2823 63331975
Eyelid irritation 44.07 9.61 23 154201 520 63334278
Dyspepsia 44.05 9.61 116 154108 102080 63232718
Drug tolerance 43.64 9.61 68 154156 6881 63327917
Overlap syndrome 43.17 9.61 27 154197 869 63333929
Engraft failure 43.16 9.61 20 154204 346 63334452
Bursitis 43.03 9.61 18 154206 37023 63297775
Toxoplasmosis 42.92 9.61 33 154191 1490 63333308
Intentional product misuse 42.68 9.61 51 154173 60866 63273932
Delirium 42.63 9.61 36 154188 50505 63284293
Cough 42.63 9.61 480 153744 292263 63042535
Nephroureterectomy 42.62 9.61 9 154215 3 63334795
Bacteraemia 42.61 9.61 115 154109 17233 63317565
Ocular discomfort 42.57 9.61 52 154172 4181 63330617
Arthralgia 42.42 9.61 1057 153167 568653 62766145
Visual acuity reduced 42.36 9.61 133 154091 21693 63313105
Toxic leukoencephalopathy 42.27 9.61 25 154199 726 63334072
Microangiopathy 42.23 9.61 30 154194 1198 63333600
Paroxysmal nocturnal haemoglobinuria 41.91 9.61 17 154207 209 63334589
Sinusitis 41.69 9.61 351 153873 226302 63108496
Oral lichen planus 41.69 9.61 24 154200 662 63334136
Renal mass 41.61 9.61 39 154185 2314 63332484
Cryptococcal meningoencephalitis 41.57 9.61 14 154210 97 63334701
Hospitalisation 41.07 9.61 91 154133 84990 63249808
Liver injury 41.00 9.61 52 154172 60468 63274330
Drug level increased 40.91 9.61 135 154089 22601 63312197
Acute lymphocytic leukaemia recurrent 40.88 9.61 38 154186 2231 63332567
Angiocentric lymphoma 40.83 9.61 23 154201 608 63334190
Instillation site reaction 40.80 9.61 21 154203 461 63334337
Cardiac arrest 40.69 9.61 104 154120 92441 63242357
Pulmonary haemorrhage 40.62 9.61 67 154157 7114 63327684
Maternal exposure during pregnancy 40.38 9.61 341 153883 219721 63115077
Chest pain 40.37 9.61 333 153891 215626 63119172
JC virus infection 40.18 9.61 36 154188 2015 63332783
Device dislocation 40.13 9.61 7 154217 25698 63309100
Rheumatoid arthritis 39.98 9.61 851 153373 252968 63081830
Bone marrow transplant 39.94 9.61 24 154200 718 63334080
Pulmonary tuberculosis 39.88 9.61 52 154172 4465 63330333
Graft loss 39.73 9.61 19 154205 354 63334444
Normal newborn 39.56 9.61 72 154152 8269 63326529
Systemic candida 39.55 9.61 44 154180 3201 63331597
Product dose omission issue 39.52 9.61 371 153853 233942 63100856
Sopor 39.45 9.61 4 154220 22160 63312638
Laryngeal disorder 39.45 9.61 27 154197 1015 63333783
Oxygen saturation decreased 39.37 9.61 99 154125 88486 63246312
Therapy non-responder 39.22 9.61 317 153907 75584 63259214
Cytomegalovirus enterocolitis 39.20 9.61 23 154201 658 63334140
Complications of transplanted lung 39.05 9.61 17 154207 252 63334546
Sedation 38.84 9.61 23 154201 38786 63296012
Human polyomavirus infection 38.81 9.61 18 154206 312 63334486
Graft versus host disease in eye 38.59 9.61 12 154212 62 63334736
Skin mass 38.41 9.61 59 154165 5896 63328902
Rheumatic disorder 38.03 9.61 42 154182 3030 63331768
Agitation 37.79 9.61 54 154170 59703 63275095
Eye swelling 37.79 9.61 136 154088 23782 63311016
Lung infiltration 37.68 9.61 98 154126 14365 63320433
Insomnia 37.52 9.61 338 153886 214914 63119884
Adrenal suppression 37.51 9.61 25 154199 899 63333899
Atrial fibrillation 37.36 9.61 151 154073 116485 63218313
Night sweats 37.35 9.61 38 154186 48776 63286022
Lupus nephritis 37.22 9.61 40 154184 2799 63331999
Granuloma 37.05 9.61 57 154167 5704 63329094
Pneumatosis intestinalis 37.04 9.61 37 154187 2376 63332422
Splenomegaly 37.01 9.61 83 154141 11074 63323724
Serum sickness 36.97 9.61 40 154184 2820 63331978
Cryptococcosis 36.90 9.61 27 154197 1130 63333668
Nephrectomy 36.75 9.61 30 154194 1478 63333320
Blood stem cell transplant failure 36.74 9.61 14 154210 144 63334654
Hip arthroplasty 36.56 9.61 37 154187 47609 63287189
Scleroderma 36.48 9.61 55 154169 5407 63329391
Escherichia urinary tract infection 36.38 9.61 86 154138 11876 63322922
Hypoproteinaemia 36.31 9.61 34 154190 2015 63332783
Jaw fracture 36.10 9.61 38 154186 2596 63332202
Condition aggravated 35.99 9.61 1253 152971 400964 62933834
Glomerulonephritis 35.98 9.61 32 154192 1774 63333024
Pyrexia 35.95 9.61 1440 152784 469038 62865760
Respiratory failure 35.87 9.61 392 153832 101466 63233332
Ill-defined disorder 35.84 9.61 92 154132 81663 63253135
Plasmablastic lymphoma 35.49 9.61 15 154209 206 63334592
Acinetobacter infection 35.48 9.61 30 154194 1553 63333245
Adenoviral hepatitis 35.47 9.61 18 154206 383 63334415
Polyomavirus-associated nephropathy 35.34 9.61 32 154192 1816 63332982
Chronic graft versus host disease in intestine 35.04 9.61 12 154212 88 63334710
Blood glucose increased 34.64 9.61 97 154127 83659 63251139
Renal tubular necrosis 34.63 9.61 84 154140 11794 63323004
Autoimmune haemolytic anaemia 34.60 9.61 49 154175 4552 63330246
Rash 34.43 9.61 1069 153155 559802 62774996
Full blood count abnormal 34.37 9.61 17 154207 31700 63303098
Idiopathic pneumonia syndrome 34.32 9.61 17 154207 343 63334455
Epicondylitis 34.26 9.61 34 154190 2166 63332632
Chest discomfort 34.20 9.61 144 154080 109825 63224973
Systemic mycosis 33.87 9.61 26 154198 1171 63333627
Mechanical ventilation 33.77 9.61 27 154197 1291 63333507
Tuberculosis gastrointestinal 33.75 9.61 17 154207 356 63334442
Lymphocele marsupialisation 33.72 9.61 8 154216 10 63334788
Clubbing 33.67 9.61 18 154206 428 63334370
Hepatitis C 33.66 9.61 52 154172 5222 63329576
Drug withdrawal syndrome 33.60 9.61 12 154212 27182 63307616
Fungaemia 33.53 9.61 35 154189 2368 63332430
Osteonecrosis of jaw 33.51 9.61 22 154202 35101 63299697
Muscle fatigue 33.39 9.61 36 154188 2528 63332270
Neoplasm progression 33.19 9.61 24 154200 36404 63298394
Lymphadenectomy 33.04 9.61 24 154200 993 63333805
Pneumocystis jirovecii infection 33.01 9.61 28 154196 1456 63333342
Herpes virus infection 33.00 9.61 53 154171 5503 63329295
Fluid retention 32.96 9.61 59 154165 59627 63275171
Eye inflammation 32.70 9.61 53 154171 5546 63329252
Asthenopia 32.54 9.61 34 154190 2303 63332495
Intentional self-injury 32.31 9.61 11 154213 25676 63309122
Opportunistic infection 32.26 9.61 31 154193 1898 63332900
Fibroadenoma of breast 32.26 9.61 18 154206 467 63334331
Haemolytic anaemia 32.12 9.61 74 154150 10051 63324747
Photophobia 31.99 9.61 105 154119 17530 63317268
Ovarian failure 31.80 9.61 26 154198 1284 63333514
Epidermodysplasia verruciformis 31.79 9.61 12 154212 120 63334678
Transient ischaemic attack 31.71 9.61 27 154197 37726 63297072
Cerebral toxoplasmosis 31.59 9.61 23 154201 955 63333843
Pulmonary nocardiosis 31.51 9.61 16 154208 341 63334457
Gastroenteritis clostridial 31.48 9.61 19 154205 573 63334225
Engraftment syndrome 31.48 9.61 18 154206 490 63334308
Eyelid disorder 31.46 9.61 30 154194 1819 63332979
Femur fracture 31.39 9.61 33 154191 41723 63293075
Joint swelling 30.96 9.61 585 153639 327081 63007717
Renal tubular injury 30.93 9.61 18 154206 507 63334291
Multiple use of single-use product 30.85 9.61 27 154197 1465 63333333
Dermatitis 30.79 9.61 101 154123 16857 63317941
Loss of consciousness 30.69 9.61 165 154059 117956 63216842
Viral test positive 30.65 9.61 14 154210 234 63334564
Bone marrow transplant rejection 30.64 9.61 10 154214 62 63334736
Post transplant distal limb syndrome 30.38 9.61 14 154210 239 63334559
Life support 30.27 9.61 14 154210 241 63334557
Pseudomonal sepsis 30.03 9.61 33 154191 2368 63332430
Enterococcal sepsis 30 9.61 26 154198 1392 63333406
Gastroenteritis rotavirus 29.99 9.61 12 154212 142 63334656
Acute respiratory distress syndrome 29.97 9.61 125 154099 23409 63311389
Unresponsive to stimuli 29.88 9.61 23 154201 33793 63301005
Blood urea increased 29.69 9.61 135 154089 26244 63308554
Blood potassium decreased 29.64 9.61 35 154189 41991 63292807
Hiatus hernia 29.42 9.61 8 154216 21586 63313212
Bacterial infection 29.22 9.61 109 154115 19390 63315408
Growth retardation 29.21 9.61 25 154199 1316 63333482
T-cell lymphoma 29.16 9.61 19 154205 657 63334141
Instillation site irritation 29.05 9.61 11 154213 111 63334687
Rheumatoid lung 28.97 9.61 41 154183 3807 63330991
Lymphadenopathy 28.92 9.61 176 154048 38282 63296516
Product storage error 28.90 9.61 91 154133 14865 63319933
Influenza like illness 28.68 9.61 76 154148 66748 63268050
Drug reaction with eosinophilia and systemic symptoms 28.66 9.61 24 154200 33812 63300986
Road traffic accident 28.62 9.61 28 154196 36604 63298194
Eyelid exfoliation 28.58 9.61 12 154212 162 63334636
Eye infection toxoplasmal 28.33 9.61 14 154210 281 63334517
Respiratory tract infection bacterial 28.24 9.61 14 154210 283 63334515
Skin disorder 28.16 9.61 144 154080 29363 63305435
Cytomegalovirus syndrome 28.13 9.61 10 154214 83 63334715
Dysplasia 28.08 9.61 21 154203 909 63333889
Cushingoid 28.01 9.61 63 154161 8422 63326376
Arthritis 27.99 9.61 416 153808 115505 63219293
Haemodialysis 27.95 9.61 65 154159 8882 63325916
Complications of transplant surgery 27.93 9.61 12 154212 172 63334626
Concomitant disease progression 27.86 9.61 30 154194 2104 63332694
Sinus tachycardia 27.86 9.61 12 154212 24256 63310542
Deep vein thrombosis 27.78 9.61 107 154117 83693 63251105
Guttate psoriasis 27.74 9.61 16 154208 443 63334355
Gouty tophus 27.69 9.61 13 154211 232 63334566
Toxic shock syndrome 27.65 9.61 20 154204 822 63333976
Pulmonary embolism 27.61 9.61 168 154056 116516 63218282
Thrombotic thrombocytopenic purpura 27.60 9.61 40 154184 3796 63331002
Complications of transplanted heart 27.55 9.61 9 154215 56 63334742
Procedural pain 27.55 9.61 9 154215 21560 63313238
Abdominal pain 27.38 9.61 525 153699 292931 63041867
Blast crisis in myelogenous leukaemia 27.38 9.61 17 154207 540 63334258
Restlessness 27.36 9.61 19 154205 29434 63305364
Haematuria 26.93 9.61 141 154083 29016 63305782
Renal lymphocele 26.89 9.61 9 154215 61 63334737
Endocrine ophthalmopathy 26.86 9.61 18 154206 653 63334145
Psoriasis area severity index increased 26.64 9.61 9 154215 63 63334735
Hyperplasia 26.54 9.61 20 154204 876 63333922
Dilatation intrahepatic duct acquired 26.50 9.61 18 154206 668 63334130
Sleep disorder 26.49 9.61 105 154119 81461 63253337
Underdose 26.47 9.61 17 154207 27439 63307359
Eyelids pruritus 26.33 9.61 22 154202 1120 63333678
Brain abscess 26.30 9.61 29 154195 2089 63332709
Retinal haemorrhage 26.29 9.61 45 154179 4924 63329874
Lymphocytic infiltration 26.26 9.61 20 154204 890 63333908
Renal arteriosclerosis 26.05 9.61 9 154215 68 63334730
Glomerulonephritis membranous 25.96 9.61 17 154207 593 63334205
Pustular psoriasis 25.95 9.61 43 154181 4583 63330215
Bone pain 25.91 9.61 59 154165 54582 63280216
Hepatitis E 25.66 9.61 24 154200 1420 63333378
Suicidal ideation 25.29 9.61 73 154151 62348 63272450
Ulcerative keratitis 25.19 9.61 32 154192 2678 63332120
Expired product administered 25.17 9.61 50 154174 6131 63328667
Gastrointestinal mucormycosis 25.17 9.61 12 154212 222 63334576
Haptoglobin decreased 25.07 9.61 18 154206 731 63334067
Vertigo 25.03 9.61 69 154155 59818 63274980
Gastropleural fistula 25.02 9.61 8 154216 46 63334752
Escherichia infection 25.01 9.61 78 154146 12676 63322122
Drug level fluctuating 24.89 9.61 15 154209 451 63334347
Rectal haemorrhage 24.86 9.61 51 154173 48979 63285819
Fungal endocarditis 24.74 9.61 12 154212 231 63334567
Cutaneous T-cell lymphoma stage IV 24.66 9.61 6 154218 9 63334789
Acute myocardial infarction 24.59 9.61 25 154199 32099 63302699
Therapy partial responder 24.53 9.61 69 154155 10589 63324209
Transaminases increased 24.51 9.61 145 154079 31222 63303576
Hepatosplenomegaly 24.50 9.61 31 154193 2583 63332215
Gait disturbance 24.46 9.61 306 153918 182872 63151926
Pneumonia lipoid 24.43 9.61 10 154214 126 63334672
Presyncope 24.42 9.61 19 154205 27766 63307032
Eye complication associated with device 24.28 9.61 6 154218 10 63334788
Rectal cancer metastatic 24.14 9.61 12 154212 244 63334554
Angiosarcoma 24.10 9.61 12 154212 245 63334553
Staphylococcal bacteraemia 24.06 9.61 46 154178 5484 63329314
Eyelid pain 23.95 9.61 13 154211 319 63334479
Anuria 23.91 9.61 76 154148 12475 63322323
Eye infection fungal 23.88 9.61 10 154214 134 63334664
Migraine 23.83 9.61 150 154074 103196 63231602
Steroid diabetes 23.75 9.61 22 154202 1286 63333512
Capillary leak syndrome 23.72 9.61 28 154196 2172 63332626
Growth failure 23.69 9.61 13 154211 326 63334472
Macular degeneration 23.62 9.61 15 154209 24361 63310437
Congenital coronary artery malformation 23.62 9.61 10 154214 138 63334660
Fungal infection 23.58 9.61 162 154062 36712 63298086
Stenotrophomonas sepsis 23.58 9.61 7 154217 30 63334768
Serotonin syndrome 23.50 9.61 21 154203 28661 63306137
Peripheral T-cell lymphoma unspecified 23.49 9.61 11 154213 195 63334603
Lower limb fracture 23.34 9.61 15 154209 24206 63310592
Morphoea 23.34 9.61 13 154211 336 63334462
Cerebral vasoconstriction 23.26 9.61 21 154203 1187 63333611
Haemosiderosis 23.19 9.61 11 154213 201 63334597
Hepatic cirrhosis 23.11 9.61 120 154104 24614 63310184
Hilar lymphadenopathy 23.06 9.61 21 154203 1201 63333597
Bacillary angiomatosis 23 9.61 9 154215 100 63334698
Nasal septum disorder 22.93 9.61 10 154214 149 63334649
Burkholderia cepacia complex infection 22.87 9.61 10 154214 150 63334648
Hepatic enzyme abnormal 22.84 9.61 49 154175 6343 63328455
Impaired work ability 22.84 9.61 7 154217 17468 63317330
Cellulitis staphylococcal 22.83 9.61 17 154207 731 63334067
Transurethral bladder resection 22.77 9.61 5 154219 3 63334795
Product use complaint 22.66 9.61 29 154195 2445 63332353
Lichenification 22.62 9.61 14 154210 442 63334356
Sinus disorder 22.60 9.61 16 154208 24537 63310261
Parvovirus infection 22.54 9.61 12 154212 283 63334515
Alopecia scarring 22.53 9.61 9 154215 106 63334692
Feeling abnormal 22.49 9.61 241 153983 148151 63186647
Groin pain 22.46 9.61 65 154159 10138 63324660
Progressive multifocal leukoencephalopathy 22.43 9.61 76 154148 12895 63321903
Iron overload 22.29 9.61 18 154206 873 63333925
Blood immunoglobulin M increased 22.27 9.61 20 154204 1123 63333675
Hypersensitivity 22.26 9.61 541 153683 292144 63042654
Weber tuning fork test abnormal 22.23 9.61 9 154215 110 63334688
Infertility 22.18 9.61 17 154207 764 63334034
Respiratory arrest 22.16 9.61 28 154196 32617 63302181
Bronchostenosis 22.02 9.61 14 154210 464 63334334
Myocardial infarction 22.01 9.61 147 154077 99746 63235052
Pruritus allergic 22.00 9.61 23 154201 1559 63333239
Therapy interrupted 21.86 9.61 28 154196 32427 63302371
Haemorrhage intracranial 21.79 9.61 77 154147 13342 63321456
Klebsiella sepsis 21.76 9.61 22 154202 1433 63333365
Intentional product use issue 21.75 9.61 202 154022 127690 63207108
Muscle spasticity 21.69 9.61 13 154211 21781 63313017
B-cell lymphoma 21.68 9.61 33 154191 3272 63331526
Clonal evolution 21.65 9.61 8 154216 75 63334723
Abdominal distension 21.40 9.61 123 154101 86492 63248306
Lacrimation decreased 21.39 9.61 13 154211 397 63334401
Swelling of eyelid 21.39 9.61 32 154192 3124 63331674
Caesarean section 21.33 9.61 90 154134 16942 63317856
Injection site swelling 21.26 9.61 53 154171 47519 63287279
Blood pressure fluctuation 21.17 9.61 51 154173 46266 63288532
Hyperbilirubinaemia 21.09 9.61 68 154156 11246 63323552
Penicillium infection 21.07 9.61 9 154215 127 63334671
Microangiopathic haemolytic anaemia 20.92 9.61 15 154209 608 63334190
Cardiac disorder 20.90 9.61 59 154165 50757 63284041
Muscular dystrophy 20.85 9.61 7 154217 48 63334750
Coma 20.81 9.61 83 154141 64281 63270517
Poisoning 20.81 9.61 4 154220 13696 63321102
MELAS syndrome 20.76 9.61 9 154215 132 63334666
Gastrointestinal disorder 20.76 9.61 211 154013 131028 63203770
Cytomegalovirus oesophagitis 20.75 9.61 11 154213 257 63334541
Genital cyst 20.72 9.61 7 154217 49 63334749
Globulins decreased 20.71 9.61 11 154213 258 63334540
Hepatic failure 20.68 9.61 153 154071 35503 63299295
Heart rate increased 20.60 9.61 139 154085 94099 63240699
Oral lichenoid reaction 20.60 9.61 8 154216 87 63334711
Stenotrophomonas infection 20.55 9.61 25 154199 2002 63332796
Corneal lesion 20.34 9.61 6 154218 25 63334773
Rhabdomyolysis 20.28 9.61 179 154045 43772 63291026
Porokeratosis 20.23 9.61 9 154215 141 63334657
Osteonecrosis 20.21 9.61 115 154109 24415 63310383
Head injury 20.20 9.61 22 154202 27374 63307424
Adenovirus reactivation 20.17 9.61 9 154215 142 63334656
Blood glucose decreased 20.16 9.61 13 154211 20939 63313859
Weight decreased 20.13 9.61 515 153709 276283 63058515
Muscular weakness 20.06 9.61 195 154029 122158 63212640
Torsade de pointes 20.06 9.61 4 154220 13347 63321451
Parvovirus B19 infection 20.05 9.61 14 154210 544 63334254
Glomerulonephritis membranoproliferative 20 9.61 10 154214 206 63334592
Pain in jaw 20.00 9.61 177 154047 43319 63291479
Leukaemia in remission 19.99 9.61 5 154219 9 63334789
Blood immunoglobulin G increased 19.98 9.61 27 154197 2400 63332398
Laser therapy 19.97 9.61 6 154218 27 63334771
Encephalitis 19.96 9.61 57 154167 8823 63325975
Blood immunoglobulin A decreased 19.86 9.61 20 154204 1297 63333501
Infected dermal cyst 19.84 9.61 13 154211 454 63334344
Papilloedema 19.83 9.61 35 154189 3925 63330873
Apoptosis 19.75 9.61 8 154216 98 63334700
Obstructive airways disorder 19.70 9.61 13 154211 20686 63314112
Neoplasm recurrence 19.70 9.61 28 154196 2610 63332188
Rash pustular 19.65 9.61 50 154174 7232 63327566
Adverse reaction 19.64 9.61 62 154162 10141 63324657
Cholelithiasis 19.58 9.61 49 154175 43876 63290922
Metapneumovirus infection 19.58 9.61 18 154206 1042 63333756
Infection reactivation 19.55 9.61 19 154205 1180 63333618
Adenoviral haemorrhagic cystitis 19.51 9.61 9 154215 154 63334644
Peritonitis 19.46 9.61 88 154136 17066 63317732
Pyoderma gangrenosum 19.40 9.61 33 154191 3592 63331206
Laryngitis viral 19.39 9.61 7 154217 61 63334737
Product packaging quantity issue 19.33 9.61 20 154204 1339 63333459
Central obesity 19.25 9.61 19 154205 1202 63333596
Lichen planus 19.23 9.61 26 154198 2312 63332486
Anaemia macrocytic 19.23 9.61 32 154192 3422 63331376
Madarosis 19.14 9.61 30 154194 3051 63331747
Concomitant disease aggravated 19.06 9.61 57 154167 9055 63325743
Chorioretinal folds 19.02 9.61 5 154219 12 63334786
Foot fracture 19.01 9.61 18 154206 23896 63310902
Pregnancy 18.94 9.61 38 154186 36798 63298000
Renal disorder 18.85 9.61 141 154083 32833 63301965
Injection site pruritus 18.84 9.61 52 154172 45064 63289734
Haemolysis 18.81 9.61 47 154177 6721 63328077
Tuberculosis 18.79 9.61 65 154159 11146 63323652
Sinus bradycardia 18.71 9.61 6 154218 14545 63320253
Primary hypogonadism 18.71 9.61 9 154215 170 63334628
Oesophageal candidiasis 18.64 9.61 42 154182 5621 63329177
Cytogenetic abnormality 18.59 9.61 13 154211 506 63334292
Psychotic disorder 18.57 9.61 21 154203 25691 63309107
Urinary retention 18.55 9.61 28 154196 30273 63304525
Metastases to liver 18.55 9.61 18 154206 23621 63311177
Lysozyme increased 18.47 9.61 5 154219 14 63334784
Still's disease 18.47 9.61 5 154219 14 63334784
Withdrawal syndrome 18.44 9.61 13 154211 19984 63314814
Live birth 18.44 9.61 21 154203 25609 63309189
Hypertensive encephalopathy 18.36 9.61 14 154210 624 63334174
Impetigo herpetiformis 18.35 9.61 8 154216 119 63334679
Lacrimal disorder 18.33 9.61 10 154214 248 63334550
Human herpesvirus 8 infection 18.33 9.61 10 154214 248 63334550
Myelodysplastic syndrome 18.31 9.61 85 154139 16669 63318129
Gastroenteritis adenovirus 18.29 9.61 10 154214 249 63334549
Low birth weight baby 18.26 9.61 48 154176 7081 63327717
Thrombosis 18.20 9.61 88 154136 64667 63270131
Renal cortical necrosis 18.17 9.61 8 154216 122 63334676
Interstitial lung disease 18.13 9.61 230 153994 61678 63273120
Emotional distress 18.13 9.61 32 154192 32517 63302281
Metastatic malignant melanoma 18.07 9.61 19 154205 1296 63333502
Acute myeloid leukaemia 18.01 9.61 86 154138 17061 63317737
Diabetic macroangiopathy 18.00 9.61 8 154216 125 63334673
Mycobacterium kansasii infection 18.00 9.61 8 154216 125 63334673
Dry mouth 17.95 9.61 113 154111 77750 63257048
Treatment noncompliance 17.94 9.61 40 154184 37285 63297513
Kidney anastomosis 17.86 9.61 4 154220 3 63334795
Skin toxicity 17.85 9.61 37 154187 4677 63330121
Eye disorder 17.81 9.61 105 154119 22580 63312218
American trypanosomiasis 17.79 9.61 7 154217 79 63334719
Amnesia 17.76 9.61 72 154152 55513 63279285
Biopsy kidney abnormal 17.76 9.61 6 154218 42 63334756
Upper gastrointestinal haemorrhage 17.73 9.61 12 154212 18840 63315958
Corynebacterium infection 17.73 9.61 13 154211 546 63334252
Rebound effect 17.70 9.61 36 154188 4490 63330308
Plasma cell myeloma 17.66 9.61 38 154186 35867 63298931
Blood calcium decreased 17.63 9.61 23 154201 26428 63308370
Lethargy 17.62 9.61 73 154151 55934 63278864
Intervertebral disc protrusion 17.53 9.61 19 154205 23690 63311108
Frequent bowel movements 17.52 9.61 18 154206 23004 63311794
Dyspnoea exertional 17.51 9.61 81 154143 60221 63274577
Juvenile idiopathic arthritis 17.44 9.61 30 154194 3296 63331502
Lung consolidation 17.43 9.61 34 154190 4114 63330684
Urinary incontinence 17.36 9.61 32 154192 31982 63302816
Septic vasculitis 17.33 9.61 4 154220 4 63334794
Renal transplant 17.32 9.61 19 154205 1361 63333437
Megakaryocytes increased 17.29 9.61 6 154218 46 63334752
Tongue ulceration 17.19 9.61 31 154193 3535 63331263
Myopathy 17.14 9.61 63 154161 11128 63323670
Aortitis salmonella 17.12 9.61 5 154219 20 63334778
Respiratory tract infection fungal 17.05 9.61 12 154212 472 63334326
Full blood count decreased 16.97 9.61 23 154201 26001 63308797
Papilloma viral infection 16.96 9.61 20 154204 1550 63333248
Red blood cell abnormality 16.94 9.61 12 154212 477 63334321
Hypertrophy of tongue papillae 16.74 9.61 5 154219 22 63334776
Adverse drug reaction 16.72 9.61 119 154105 79595 63255203
Phaeohyphomycosis 16.71 9.61 10 154214 297 63334501
Reversible cerebral vasoconstriction syndrome 16.68 9.61 26 154198 2632 63332166
Tachycardia 16.67 9.61 195 154029 117961 63216837
Muscle twitching 16.60 9.61 14 154210 19654 63315144
Tremor 16.51 9.61 224 154000 132015 63202783
Hypertension 16.47 9.61 833 153391 278470 63056328
Guillain-Barre syndrome 16.47 9.61 32 154192 3861 63330937
Immunosuppression 16.45 9.61 53 154171 8761 63326037
Primary effusion lymphoma 16.44 9.61 4 154220 6 63334792
Pyelonephritis 16.43 9.61 86 154138 17692 63317106
Soft tissue infection 16.43 9.61 23 154201 2114 63332684
Palmar-plantar erythrodysaesthesia syndrome 16.41 9.61 19 154205 22996 63311802
Dry eye 16.30 9.61 161 154063 40600 63294198
Inappropriate schedule of product administration 16.15 9.61 348 153876 103617 63231181
Septic embolus 16.12 9.61 15 154209 882 63333916
Chloroma 16.11 9.61 9 154215 234 63334564
Mouth ulceration 16.09 9.61 136 154088 32848 63301950
Epistaxis 16.03 9.61 107 154117 72618 63262180
Conjunctival hyperaemia 15.95 9.61 24 154200 2355 63332443
Pain in extremity 15.89 9.61 651 153573 330835 63003963
Restless legs syndrome 15.87 9.61 13 154211 18518 63316280
Actinomycotic sepsis 15.83 9.61 7 154217 108 63334690
Hepatomegaly 15.81 9.61 64 154160 11825 63322973
Pulmonary alveolar haemorrhage 15.79 9.61 35 154189 4633 63330165
Pain of skin 15.77 9.61 63 154161 11571 63323227
Hepatitis B 15.72 9.61 31 154193 3781 63331017
Enterobacter infection 15.70 9.61 23 154201 2204 63332594
Transitional cell carcinoma 15.69 9.61 13 154211 654 63334144
Eyelid margin crusting 15.65 9.61 16 154208 1056 63333742
Pneumonia klebsiella 15.65 9.61 24 154200 2395 63332403
Aplasia 15.63 9.61 33 154191 4226 63330572
Incorrect dose administered 15.57 9.61 218 154006 59750 63275048
Moraxella infection 15.56 9.61 11 154213 436 63334362
Eating disorder 15.48 9.61 14 154210 19002 63315796
Type IIb hyperlipidaemia 15.46 9.61 5 154219 30 63334768
Exercise tolerance increased 15.46 9.61 5 154219 30 63334768
Oliguria 15.45 9.61 53 154171 9048 63325750
Fungal test positive 15.45 9.61 12 154212 550 63334248
Aspergillus test positive 15.45 9.61 10 154214 342 63334456
Stevens-Johnson syndrome 15.33 9.61 23 154201 24927 63309871
Skin lesion removal 15.31 9.61 6 154218 67 63334731
Adjusted calcium decreased 15.28 9.61 8 154216 182 63334616
Neck pain 15.28 9.61 245 153979 69073 63265725
Intracranial pressure increased 15.27 9.61 37 154187 5190 63329608
Throat tightness 15.23 9.61 23 154201 24864 63309934
Renal tubular disorder 15.14 9.61 25 154199 2657 63332141
Alpha haemolytic streptococcal infection 15.13 9.61 17 154207 1250 63333548
Drug level decreased 15.13 9.61 48 154176 7871 63326927
Reticulocyte count increased 15.12 9.61 15 154209 955 63333843
Conjunctival oedema 15.11 9.61 13 154211 689 63334109
Breast cancer female 15.10 9.61 7 154217 13552 63321246
Serratia infection 15.08 9.61 15 154209 958 63333840
Punctal plug insertion 15.07 9.61 3 154221 0 63334798
Aqueous humour leakage 15.07 9.61 3 154221 0 63334798
Ewing's sarcoma recurrent 15.07 9.61 3 154221 0 63334798
Drug hypersensitivity 15.06 9.61 910 153314 309777 63025021
Cataract 15.06 9.61 208 154016 56845 63277953
Arterial thrombosis 14.96 9.61 18 154206 1425 63333373
Fear 14.87 9.61 10 154214 15756 63319042
Pterygium 14.86 9.61 8 154216 193 63334605
Haemorrhagic cyst 14.82 9.61 8 154216 194 63334604
Jejunal ulcer perforation 14.80 9.61 5 154219 35 63334763
Infection masked 14.80 9.61 5 154219 35 63334763
Laryngeal mass 14.80 9.61 5 154219 35 63334763
Keratoacanthoma 14.79 9.61 11 154213 472 63334326
Foetal exposure during pregnancy 14.76 9.61 35 154189 31927 63302871
Platelet count decreased 14.75 9.61 378 153846 115744 63219054
Chronic spontaneous urticaria 14.64 9.61 16 154208 1141 63333657
Mycotic allergy 14.61 9.61 15 154209 995 63333803
Dermatitis exfoliative generalised 14.55 9.61 30 154194 3777 63331021
Diabetic ketoacidosis 14.54 9.61 17 154207 20488 63314310
Coronary artery disease 14.52 9.61 36 154188 32341 63302457
Erythrodermic psoriasis 14.51 9.61 15 154209 1003 63333795
Pallor 14.50 9.61 33 154191 30535 63304263
Parakeratosis 14.49 9.61 9 154215 286 63334512
Acute disseminated encephalomyelitis 14.46 9.61 8 154216 204 63334594
Vaginal haemorrhage 14.44 9.61 28 154196 27459 63307339
Heart rate irregular 14.43 9.61 20 154204 22401 63312397
Hypocalcaemia 14.43 9.61 35 154189 31678 63303120
Squamous cell carcinoma of skin 14.41 9.61 40 154184 6092 63328706
Staphylococcal sepsis 14.39 9.61 48 154176 8080 63326718
Central nervous system lymphoma 14.38 9.61 18 154206 1484 63333314
Injection site haemorrhage 14.38 9.61 23 154201 24291 63310507
Disability 14.36 9.61 14 154210 18333 63316465
Myoglobinuria 14.35 9.61 9 154215 291 63334507
Lip dry 14.34 9.61 10 154214 15460 63319338
Instillation site dryness 14.34 9.61 4 154220 13 63334785
Periportal oedema 14.34 9.61 4 154220 13 63334785
Reticulocytosis 14.32 9.61 7 154217 137 63334661
Panic attack 14.29 9.61 20 154204 22311 63312487
Disease progression 14.27 9.61 395 153829 122363 63212435
Transfusion-related acute lung injury 14.23 9.61 7 154217 139 63334659
Ureteric stenosis 14.23 9.61 12 154212 619 63334179
Hepatic fibrosis 14.22 9.61 29 154195 3623 63331175
Myasthenia gravis crisis 14.22 9.61 11 154213 501 63334297
Mycoplasma infection 14.18 9.61 11 154213 503 63334295
Pericardial effusion 14.17 9.61 123 154101 29935 63304863
Escherichia sepsis 14.16 9.61 35 154189 4972 63329826
Gastroenteritis norovirus 14.06 9.61 21 154203 2047 63332751
CSF protein increased 14.05 9.61 11 154213 510 63334288
Vesicoureteric reflux 14.05 9.61 8 154216 216 63334582
Glomerulonephropathy 14.03 9.61 6 154218 85 63334713
Febrile neutropenia 14.02 9.61 382 153842 118067 63216731
Mycobacterium fortuitum infection 14.01 9.61 5 154219 42 63334756
Hallucination 13.99 9.61 77 154147 54740 63280058
Pancreas transplant rejection 13.92 9.61 7 154217 146 63334652
Abnormal behaviour 13.90 9.61 19 154205 21407 63313391
Neoplasm skin 13.83 9.61 18 154206 1543 63333255
Pneumonia herpes viral 13.81 9.61 5 154219 44 63334754
Hypotony of eye 13.79 9.61 7 154217 149 63334649
Malignant neoplasm of conjunctiva 13.71 9.61 5 154219 45 63334753
Breast cancer metastatic 13.70 9.61 6 154218 12012 63322786
Ureteral neoplasm 13.69 9.61 4 154220 16 63334782
Infective chondritis 13.69 9.61 4 154220 16 63334782
Lipohypertrophy 13.68 9.61 12 154212 653 63334145
Nephrolithiasis 13.66 9.61 54 154170 41930 63292868
Pre-eclampsia 13.64 9.61 51 154173 9082 63325716
Autoimmune thyroiditis 13.61 9.61 30 154194 3956 63330842
Renal cell carcinoma 13.61 9.61 27 154197 3308 63331490
Anaphylactic reaction 13.60 9.61 231 153993 65869 63268929
Pneumonia staphylococcal 13.59 9.61 25 154199 2895 63331903
Chronic myeloid leukaemia recurrent 13.57 9.61 8 154216 231 63334567
Atypical mycobacterial infection 13.55 9.61 15 154209 1085 63333713
Intervertebral disc degeneration 13.52 9.61 11 154213 15721 63319077
Nephroblastoma 13.50 9.61 4 154220 17 63334781
Haematemesis 13.50 9.61 34 154190 30378 63304420
Adjustment disorder with depressed mood 13.49 9.61 4 154220 10200 63324598
Streptococcal bacteraemia 13.48 9.61 19 154205 1758 63333040
Chronic kidney disease 13.43 9.61 169 154055 45229 63289569
Foreign body reaction 13.43 9.61 6 154218 95 63334703
Toe amputation 13.41 9.61 20 154204 1947 63332851
Coccidioidomycosis 13.38 9.61 14 154210 950 63333848
Sleep apnoea syndrome 13.38 9.61 32 154192 29101 63305697
Mucosal ulceration 13.34 9.61 14 154210 953 63333845
Encephalitis cytomegalovirus 13.34 9.61 11 154213 550 63334248
Prescribed underdose 13.32 9.61 33 154191 29656 63305142
Psychomotor disadaptation syndrome 13.32 9.61 4 154220 18 63334780
Neuropathy peripheral 13.31 9.61 195 154029 113472 63221326
Gallbladder rupture 13.29 9.61 10 154214 437 63334361
Corneal abrasion 13.29 9.61 15 154209 1109 63333689
Feeling hot 13.26 9.61 70 154154 50284 63284514
Fibromyalgia 13.25 9.61 128 154096 80292 63254506
Small intestinal obstruction 13.22 9.61 15 154209 18322 63316476
Meningoradiculitis 13.20 9.61 6 154218 99 63334699
Human herpes virus 6 serology positive 13.20 9.61 6 154218 99 63334699
Dyschromatopsia 13.17 9.61 10 154214 443 63334355
Focal nodular hyperplasia 13.17 9.61 11 154213 560 63334238
Disturbance in attention 13.15 9.61 48 154176 38141 63296657
Rhinitis allergic 13.14 9.61 6 154218 11721 63323077
Occult blood 13.11 9.61 16 154208 1285 63333513
Encapsulating peritoneal sclerosis 13.09 9.61 9 154215 341 63334457
Ophthalmic herpes simplex 13.03 9.61 10 154214 450 63334348
Nail pterygium 13.00 9.61 3 154221 3 63334795
Carcinoid tumour of the gastrointestinal tract 13.00 9.61 3 154221 3 63334795
Keratolysis exfoliativa acquired 13.00 9.61 3 154221 3 63334795
Lung squamous cell carcinoma metastatic 13.00 9.61 3 154221 3 63334795
Coxsackie virus test positive 13.00 9.61 3 154221 3 63334795
Removal of transplanted organ 13.00 9.61 3 154221 3 63334795
Intestinal ulcer perforation 13.00 9.61 3 154221 3 63334795
Fasciitis 12.98 9.61 11 154213 571 63334227
Tongue pigmentation 12.97 9.61 4 154220 20 63334778
Overdose 12.93 9.61 199 154025 114879 63219919
Generalised oedema 12.93 9.61 74 154150 15744 63319054
Depressed mood 12.88 9.61 52 154172 40139 63294659
Clonic convulsion 12.79 9.61 12 154212 713 63334085
Device breakage 12.79 9.61 6 154218 11536 63323262
Weight fluctuation 12.71 9.61 4 154220 9815 63324983
Acid base balance abnormal 12.69 9.61 8 154216 261 63334537
Bronchospasm 12.61 9.61 14 154210 17266 63317532
Osteoporotic fracture 12.57 9.61 28 154196 3718 63331080
Systemic inflammatory response syndrome 12.56 9.61 36 154188 5585 63329213
Thrombocytopenia 12.52 9.61 467 153757 150690 63184108
Peripheral artery aneurysm 12.51 9.61 5 154219 59 63334739
Device malfunction 12.45 9.61 15 154209 17842 63316956
Vasogenic cerebral oedema 12.41 9.61 13 154211 883 63333915
Red cell distribution width increased 12.41 9.61 5 154219 10519 63324279
Meningitis cryptococcal 12.39 9.61 16 154208 1361 63333437
Leukodystrophy 12.37 9.61 4 154220 24 63334774
Extubation 12.37 9.61 4 154220 24 63334774
Skin hyperpigmentation 12.35 9.61 37 154187 5884 63328914
Metastases to bone 12.32 9.61 20 154204 20999 63313799
Perinephric collection 12.25 9.61 6 154218 118 63334680
Neuralgic amyotrophy 12.23 9.61 4 154220 25 63334773
Exposure during pregnancy 12.22 9.61 286 153938 155261 63179537
Vascular pseudoaneurysm ruptured 12.22 9.61 5 154219 63 63334735
Miliaria 12.18 9.61 15 154209 1216 63333582
Photosensitivity reaction 12.16 9.61 70 154154 14924 63319874
Obesity 12.15 9.61 35 154189 29917 63304881
Unevaluable event 12.14 9.61 74 154150 51312 63283486
Dislocation of vertebra 12.14 9.61 3 154221 8632 63326166
Diffuse alveolar damage 12.14 9.61 13 154211 906 63333892
Renal haematoma 12.13 9.61 7 154217 194 63334604
Complication associated with device 12.12 9.61 14 154210 16964 63317834
Glomerulonephritis proliferative 12.10 9.61 7 154217 195 63334603
Ciliary body disorder 12.09 9.61 4 154220 26 63334772
Hypertrophic cardiomyopathy 12.08 9.61 17 154207 1570 63333228
Cardiac valve vegetation 12.07 9.61 8 154216 285 63334513
Skin neoplasm excision 12.06 9.61 12 154212 767 63334031
Respiratory gas exchange disorder 12.05 9.61 9 154215 389 63334409
Urinary tract infection viral 12.01 9.61 5 154219 66 63334732
Pulmonary toxicity 11.98 9.61 4 154220 9451 63325347
Keratitis 11.96 9.61 26 154198 3396 63331402
Pneumothorax 11.96 9.61 74 154150 16187 63318611
Endotracheal intubation 11.85 9.61 22 154202 2566 63332232
Disseminated Bacillus Calmette-Guerin infection 11.84 9.61 4 154220 28 63334770
Thirst 11.84 9.61 10 154214 14031 63320767
Blindness cortical 11.84 9.61 10 154214 517 63334281
Cholangitis 11.83 9.61 35 154189 5526 63329272
Arrhythmia 11.81 9.61 50 154174 38090 63296708
Blood gonadotrophin increased 11.79 9.61 3 154221 6 63334792
Cord blood transplant therapy 11.79 9.61 3 154221 6 63334792
Adenoviral encephalitis 11.79 9.61 3 154221 6 63334792
Extrapyramidal disorder 11.78 9.61 9 154215 13275 63321523
Hyperthyroidism 11.71 9.61 11 154213 14662 63320136
Ocular vascular disorder 11.71 9.61 9 154215 406 63334392
Erythropoiesis abnormal 11.68 9.61 8 154216 301 63334497
Genital discomfort 11.68 9.61 5 154219 71 63334727
Cytomegalovirus gastrointestinal infection 11.66 9.61 8 154216 302 63334496
Pyogenic granuloma 11.57 9.61 8 154216 306 63334492
Concussion 11.56 9.61 4 154220 9240 63325558
Injection site induration 11.52 9.61 4 154220 9222 63325576
Tooth infection 11.52 9.61 16 154208 17904 63316894
Keratomileusis 11.47 9.61 3 154221 7 63334791
Mania 11.46 9.61 8 154216 12359 63322439
Biopsy muscle abnormal 11.38 9.61 4 154220 32 63334766
Therapy cessation 11.35 9.61 37 154187 30420 63304378
Urticaria pressure 11.27 9.61 4 154220 33 63334765
Choroidal detachment 11.26 9.61 7 154217 223 63334575
Hepatitis C virus test 11.19 9.61 3 154221 8 63334790
Necrosis 11.17 9.61 34 154190 5453 63329345
Eosinophilic pustular folliculitis 11.17 9.61 4 154220 34 63334764
Dyskinesia 11.16 9.61 40 154184 31962 63302836
Plantar fascial fibromatosis 11.14 9.61 6 154218 145 63334653
Squamous cell carcinoma of the cervix 11.12 9.61 8 154216 326 63334472
Acute hepatitis C 11.09 9.61 5 154219 81 63334717
Pneumonia bacterial 11.07 9.61 49 154175 9416 63325382
Nasal ulcer 11.07 9.61 20 154204 2284 63332514
Pancreatic steatosis 11.07 9.61 13 154211 1003 63333795
Bone marrow myelogram abnormal 11.07 9.61 4 154220 35 63334763
Laryngitis 11.06 9.61 15 154209 16952 63317846
X-ray abnormal 11.06 9.61 3 154221 8107 63326691
Creatinine renal clearance decreased 11.06 9.61 14 154210 16294 63318504
Tumour lysis syndrome 11.05 9.61 4 154220 8986 63325812
Renal artery stenosis 11.05 9.61 18 154206 1891 63332907
Anal incontinence 11.05 9.61 10 154214 13566 63321232
Myocarditis 11.00 9.61 52 154172 10273 63324525
Reticulocytopenia 10.98 9.61 5 154219 83 63334715
Epstein-Barr virus antibody positive 10.95 9.61 8 154216 334 63334464
Glutamate dehydrogenase level abnormal 10.93 9.61 3 154221 9 63334789
Arteriosclerotic retinopathy 10.93 9.61 3 154221 9 63334789
Pharyngeal necrosis 10.93 9.61 3 154221 9 63334789
CD4 lymphocytes increased 10.88 9.61 6 154218 152 63334646
Skin haemorrhage 10.87 9.61 51 154173 10043 63324755
Tanning 10.87 9.61 5 154219 85 63334713
Ventricular tachycardia 10.81 9.61 20 154204 19959 63314839
Peripheral venous disease 10.79 9.61 13 154211 15464 63319334
Nail dystrophy 10.79 9.61 13 154211 1030 63333768
Atypical haemolytic uraemic syndrome 10.79 9.61 11 154213 724 63334074
Thyroglossal cyst infection 10.78 9.61 4 154220 38 63334760
Feeling jittery 10.76 9.61 10 154214 13393 63321405
Legionella infection 10.72 9.61 9 154215 461 63334337
Haematochezia 10.71 9.61 81 154143 53463 63281335
Eye infection 10.71 9.61 58 154166 12087 63322711
Faecaloma 10.71 9.61 3 154221 7938 63326860
Cytomegalovirus gastrointestinal ulcer 10.69 9.61 3 154221 10 63334788
Removal of renal transplant 10.69 9.61 3 154221 10 63334788
Post procedural urine leak 10.69 9.61 4 154220 39 63334759
Hepatic haematoma 10.67 9.61 9 154215 464 63334334
Aggression 10.64 9.61 26 154198 23472 63311326
Cutaneous lymphoma 10.60 9.61 6 154218 160 63334638
Lymphadenopathy mediastinal 10.58 9.61 22 154202 2786 63332012
Joint stiffness 10.58 9.61 59 154165 41810 63292988
Nightmare 10.57 9.61 19 154205 19175 63315623
Heart rate decreased 10.56 9.61 66 154158 45494 63289304
Musculoskeletal stiffness 10.53 9.61 355 153869 184263 63150535
CSF white blood cell count increased 10.51 9.61 4 154220 41 63334757
Laparotomy 10.50 9.61 8 154216 356 63334442
Genital lesion 10.49 9.61 7 154217 252 63334546
Megakaryocytes decreased 10.47 9.61 3 154221 11 63334787
Parainfluenzae viral bronchitis 10.47 9.61 3 154221 11 63334787
Aortic intramural haematoma 10.46 9.61 5 154219 93 63334705
Oedema mucosal 10.46 9.61 13 154211 1064 63333734
Eosinophilic myocarditis 10.44 9.61 10 154214 610 63334188
Punctate keratitis 10.42 9.61 10 154214 611 63334187
Vascular graft complication 10.42 9.61 4 154220 42 63334756
Acarodermatitis 10.40 9.61 13 154211 1070 63333728
Tooth extraction 10.39 9.61 6 154218 10258 63324540
Drug dependence 10.38 9.61 28 154196 24455 63310343
Skin laceration 10.38 9.61 25 154199 22683 63312115
Candida pneumonia 10.37 9.61 6 154218 167 63334631
Stomatitis 10.37 9.61 257 153967 138468 63196330
Dysarthria 10.36 9.61 61 154163 42650 63292148
Meningism 10.32 9.61 9 154215 486 63334312
Human herpesvirus 6 infection reactivation 10.31 9.61 8 154216 366 63334432
Secondary hypertension 10.31 9.61 6 154218 169 63334629
Phospholipidosis 10.31 9.61 6 154218 169 63334629
Renal infarct 10.28 9.61 15 154209 1432 63333366
Infestation 10.26 9.61 4 154220 44 63334754
Pancreatic atrophy 10.25 9.61 6 154218 171 63334627
Diabetes mellitus inadequate control 10.24 9.61 13 154211 15113 63319685
Device issue 10.24 9.61 27 154197 23754 63311044
Rib fracture 10.23 9.61 25 154199 22572 63312226
Gamma-glutamyltransferase increased 10.20 9.61 127 154097 33904 63300894
Enterococcal bacteraemia 10.19 9.61 15 154209 1444 63333354
Sinonasal papilloma 10.18 9.61 4 154220 45 63334753
Superinfection bacterial 10.13 9.61 10 154214 633 63334165
Skin hypopigmentation 10.12 9.61 11 154213 780 63334018
No adverse event 10.11 9.61 59 154165 41346 63293452
Streptococcal infection 10.09 9.61 34 154190 5753 63329045
Meibomian gland dysfunction 10.06 9.61 6 154218 177 63334621
Central nervous system vasculitis 10.05 9.61 12 154212 942 63333856
Ureaplasma infection 10.03 9.61 10 154214 641 63334157
Vaccination site inflammation 10.02 9.61 4 154220 47 63334751
Injection site rash 10.02 9.61 19 154205 18790 63316008
Cytokine release syndrome 10.01 9.61 12 154212 14302 63320496
Haemochromatosis 10.00 9.61 9 154215 507 63334291
Sinus congestion 9.93 9.61 18 154206 18105 63316693
Anogenital warts 9.92 9.61 9 154215 512 63334286
Chronic hepatitis C 9.91 9.61 6 154218 182 63334616
Mental status changes 9.90 9.61 56 154168 39543 63295255
Ubiquinone decreased 9.90 9.61 3 154221 14 63334784
Pre-existing condition improved 9.89 9.61 43 154181 8201 63326597
Poor quality sleep 9.88 9.61 21 154203 19914 63314884
Allergic transfusion reaction 9.87 9.61 4 154220 49 63334749
Walking aid user 9.84 9.61 7 154217 10710 63324088
Grip strength decreased 9.82 9.61 25 154199 22262 63312536
Cytomegalovirus gastritis 9.82 9.61 6 154218 185 63334613
Renal vein thrombosis 9.80 9.61 8 154216 394 63334404
Upper respiratory tract inflammation 9.78 9.61 20 154204 2503 63332295
Complications of transplanted liver 9.75 9.61 8 154216 397 63334401
Kidney enlargement 9.75 9.61 10 154214 663 63334135
Pneumonia pseudomonal 9.73 9.61 20 154204 2513 63332285
Burkitt's lymphoma 9.73 9.61 3 154221 15 63334783
Galectin-3 increased 9.73 9.61 3 154221 15 63334783
Corneal transplant 9.71 9.61 7 154217 286 63334512
Dehiscence 9.70 9.61 5 154219 110 63334688
Hair growth abnormal 9.69 9.61 22 154202 2959 63331839
Dysmetria 9.69 9.61 9 154215 528 63334270
Parenteral nutrition 9.66 9.61 4 154220 52 63334746
Varicella 9.65 9.61 17 154207 1904 63332894

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 1891.94 10.79 1164 121296 24971 34809500
Graft versus host disease 1274.07 10.79 658 121802 9911 34824560
Acute graft versus host disease 1052.61 10.79 495 121965 6008 34828463
Acute graft versus host disease in skin 1037.76 10.79 458 122002 4743 34829728
Product use in unapproved indication 954.34 10.79 1574 120886 115925 34718546
Chronic graft versus host disease 947.07 10.79 408 122052 3965 34830506
Epstein-Barr virus infection 778.17 10.79 425 122035 7203 34827268
Post transplant lymphoproliferative disorder 731.10 10.79 387 122073 6141 34828330
Graft versus host disease in gastrointestinal tract 711.16 10.79 317 122143 3366 34831105
Kidney transplant rejection 654.12 10.79 377 122083 7120 34827351
Posterior reversible encephalopathy syndrome 591.88 10.79 392 122068 9562 34824909
Graft versus host disease in skin 541.96 10.79 268 122192 3657 34830814
Transplant rejection 536.77 10.79 374 122086 9937 34824534
BK virus infection 515.15 10.79 294 122166 5444 34829027
Acute graft versus host disease in intestine 506.60 10.79 228 122232 2480 34831991
Nephropathy toxic 478.68 10.79 378 122082 12210 34822261
Cytomegalovirus infection reactivation 437.49 10.79 254 122206 4864 34829607
Cystitis haemorrhagic 413.03 10.79 254 122206 5425 34829046
Fatigue 393.02 10.79 433 122027 370220 34464251
Thrombotic microangiopathy 388.75 10.79 312 122148 10318 34824153
Blood creatinine increased 356.00 10.79 926 121534 94050 34740421
Acute graft versus host disease in liver 345.23 10.79 148 122312 1418 34833053
Epstein-Barr virus associated lymphoproliferative disorder 344.14 10.79 158 122302 1806 34832665
Drug abuse 321.43 10.79 5 122455 99091 34735380
Complications of transplanted kidney 319.61 10.79 200 122260 4409 34830062
Dizziness 319.16 10.79 185 122275 218336 34616135
Renal impairment 306.67 10.79 874 121586 93639 34740832
Completed suicide 306.27 10.79 8 122452 98160 34736311
Adenovirus infection 305.16 10.79 204 122256 5053 34829418
Chronic graft versus host disease in skin 300.04 10.79 117 122343 857 34833614
Cytomegalovirus viraemia 282.19 10.79 223 122237 7207 34827264
Fall 281.95 10.79 182 122278 202703 34631768
Aspergillus infection 269.64 10.79 270 122190 11984 34822487
Drug ineffective 266.42 10.79 2600 119860 454151 34380320
Heart transplant rejection 253.89 10.79 111 122349 1120 34833351
Death 253.68 10.79 646 121814 397403 34437068
Bronchopulmonary aspergillosis 253.29 10.79 284 122176 14375 34820096
Gingival hypertrophy 250.37 10.79 124 122336 1697 34832774
Immunosuppressant drug level increased 241.34 10.79 187 122273 5868 34828603
Pneumonia cytomegaloviral 230.78 10.79 140 122320 2914 34831557
Graft versus host disease in liver 230.32 10.79 105 122355 1179 34833292
Hepatic function abnormal 226.25 10.79 488 121972 43875 34790596
Hypotension 204.81 10.79 287 122173 221362 34613109
Liver transplant rejection 202.14 10.79 113 122347 2006 34832465
Multiple organ dysfunction syndrome 201.33 10.79 658 121802 75908 34758563
Chronic graft versus host disease in liver 195.77 10.79 70 122390 389 34834082
Dyspnoea 193.30 10.79 676 121784 376106 34458365
Drug eruption 191.90 10.79 289 122171 19609 34814862
Polyomavirus viraemia 187.74 10.79 83 122377 862 34833609
Product dose omission issue 186.73 10.79 93 122367 119618 34714853
Eye irritation 185.79 10.79 177 122283 7384 34827087
Venoocclusive disease 185.28 10.79 119 122341 2748 34831723
Cytomegalovirus test positive 183.82 10.79 133 122327 3753 34830718
Transplant dysfunction 183.79 10.79 115 122345 2534 34831937
Polyomavirus-associated nephropathy 182.83 10.79 132 122328 3712 34830759
Syncope 177.80 10.79 50 122410 91401 34743070
Obliterative bronchiolitis 177.26 10.79 87 122373 1166 34833305
Transplant failure 173.55 10.79 124 122336 3429 34831042
Immunosuppressant drug level decreased 171.24 10.79 85 122375 1169 34833302
Haemophagocytic lymphohistiocytosis 167.82 10.79 217 122243 12756 34821715
Constipation 165.43 10.79 142 122318 136840 34697631
Asthenia 163.63 10.79 388 122072 244863 34589608
Squamous cell carcinoma 162.81 10.79 201 122259 11274 34823197
Chronic allograft nephropathy 162.22 10.79 82 122378 1175 34833296
Mucormycosis 157.33 10.79 145 122315 5797 34828674
Therapy non-responder 151.89 10.79 387 122073 38759 34795712
Pneumocystis jirovecii pneumonia 148.65 10.79 256 122204 19454 34815017
Proteinuria 148.36 10.79 248 122212 18394 34816077
Pyrexia 146.28 10.79 1794 120666 331219 34503252
Somnolence 141.83 10.79 109 122351 111007 34723464
Treatment failure 139.88 10.79 420 122040 46277 34788194
Anxiety 135.44 10.79 91 122369 99337 34735134
Chronic graft versus host disease in intestine 134.82 10.79 46 122414 217 34834254
Intentional overdose 134.51 10.79 4 122456 43670 34790801
Human herpesvirus 6 infection 126.20 10.79 83 122377 1998 34832473
Oral administration complication 125.05 10.79 32 122428 36 34834435
Lymphoproliferative disorder 124.99 10.79 92 122368 2667 34831804
Stomatitis 124.15 10.79 379 122081 42135 34792336
Mucosal inflammation 122.94 10.79 355 122105 38267 34796204
Overdose 121.80 10.79 85 122375 90974 34743497
Kidney fibrosis 121.05 10.79 83 122377 2145 34832326
Lymphocele 117.69 10.79 68 122392 1289 34833182
Bradycardia 115.43 10.79 60 122400 75358 34759113
Hyperhidrosis 114.70 10.79 61 122399 75631 34758840
Drug resistance 114.03 10.79 269 122191 25658 34808813
Epstein-Barr virus infection reactivation 113.90 10.79 62 122398 1042 34833429
JC virus infection 112.33 10.79 79 122381 2129 34832342
Chest pain 109.23 10.79 172 122288 126590 34707881
Cardiac failure congestive 108.39 10.79 80 122380 83190 34751281
Complications of bone marrow transplant 107.51 10.79 38 122422 203 34834268
Venoocclusive liver disease 107.35 10.79 136 122324 7830 34826641
Malignant neoplasm progression 102.93 10.79 94 122366 87952 34746519
Pain 102.72 10.79 370 122090 204305 34630166
Enterococcal infection 102.56 10.79 144 122316 9162 34825309
Pseudomonas infection 101.57 10.79 167 122293 12215 34822256
Back pain 101.42 10.79 169 122291 121620 34712851
Psoriasis 101.41 10.79 333 122127 38479 34795992
Disease recurrence 101.14 10.79 229 122231 21261 34813210
Lung transplant rejection 100.26 10.79 51 122409 741 34833730
Dehydration 98.67 10.79 191 122269 129778 34704693
Coombs positive haemolytic anaemia 98.66 10.79 54 122406 918 34833553
Decreased appetite 97.24 10.79 281 122179 166111 34668360
Viraemia 96.76 10.79 58 122402 1180 34833291
Chronic obstructive pulmonary disease 96.43 10.79 26 122434 48892 34785579
End stage renal disease 96.00 10.79 136 122324 8725 34825746
Myocardial infarction 95.39 10.79 174 122286 120911 34713560
Kaposi's sarcoma 95.04 10.79 51 122409 832 34833639
Fungal infection 94.96 10.79 187 122273 15748 34818723
Haemolysis 94.83 10.79 129 122331 7965 34826506
Suicide attempt 91.16 10.79 14 122446 39102 34795369
Graft versus host disease in lung 90.00 10.79 43 122417 541 34833930
Renal transplant failure 89.53 10.79 53 122407 1053 34833418
Diffuse large B-cell lymphoma 88.69 10.79 119 122341 7251 34827220
Hypogammaglobulinaemia 88.63 10.79 122 122338 7618 34826853
Atrial fibrillation 88.51 10.79 185 122275 122208 34712263
Cytomegalovirus chorioretinitis 88.13 10.79 84 122376 3505 34830966
Tenosynovitis 86.66 10.79 93 122367 4477 34829994
Hepatitis E 86.57 10.79 66 122394 2020 34832451
Acute myeloid leukaemia recurrent 86.43 10.79 67 122393 2103 34832368
Injection site pain 86.38 10.79 16 122444 38989 34795482
Hyponatraemia 84.54 10.79 99 122361 82592 34751879
Graft loss 83.98 10.79 47 122413 836 34833635
Hypoglycaemia 82.81 10.79 44 122416 54596 34779875
Focal segmental glomerulosclerosis 81.69 10.79 63 122397 1962 34832509
Confusional state 80.92 10.79 248 122212 143912 34690559
Skin plaque 80.72 10.79 90 122370 4524 34829947
Depression 80.57 10.79 135 122325 96963 34737508
Neurotoxicity 80.42 10.79 188 122272 17822 34816649
Malaise 79.27 10.79 358 122102 185467 34649004
Blood bilirubin increased 78.95 10.79 304 122156 37992 34796479
Viral haemorrhagic cystitis 78.78 10.79 50 122410 1130 34833341
Cerebrovascular accident 77.95 10.79 110 122350 84701 34749770
Progressive multifocal leukoencephalopathy 77.81 10.79 130 122330 9634 34824837
Staphylococcal infection 77.58 10.79 272 122188 32488 34801983
Agitation 77.50 10.79 53 122407 57346 34777125
Enthesopathy 77.32 10.79 88 122372 4525 34829946
Bacterial infection 77.16 10.79 179 122281 16884 34817587
Electrocardiogram QT prolonged 76.61 10.79 24 122436 40928 34793543
Graft versus host disease in eye 76.43 10.79 30 122430 224 34834247
Drug ineffective for unapproved indication 76.43 10.79 219 122241 23496 34810975
Herpes simplex 75.05 10.79 95 122365 5464 34829007
Intentional product misuse 74.80 10.79 33 122427 45578 34788893
Alanine aminotransferase abnormal 74.49 10.79 87 122373 4601 34829870
Renal tubular atrophy 74.14 10.79 48 122412 1124 34833347
Chronic graft versus host disease oral 74.13 10.79 25 122435 113 34834358
Epstein-Barr viraemia 73.95 10.79 50 122410 1262 34833209
Engraftment syndrome 73.52 10.79 45 122415 952 34833519
Haemodialysis 73.25 10.79 132 122328 10394 34824077
Hirsutism 72.96 10.79 27 122433 168 34834303
Concomitant disease progression 71.67 10.79 64 122396 2454 34832017
Suicidal ideation 71.49 10.79 26 122434 40362 34794109
Nocardiosis 70.73 10.79 78 122382 3873 34830598
International normalised ratio increased 70.42 10.79 39 122421 47288 34787183
Hypertension 70.29 10.79 759 121701 135684 34698787
Weight increased 69.46 10.79 138 122322 92895 34741576
Aplasia pure red cell 69.23 10.79 96 122364 6036 34828435
Balance disorder 68.93 10.79 28 122432 40626 34793845
Pulmonary embolism 68.85 10.79 131 122329 89615 34744856
Rash 68.44 10.79 478 121982 222274 34612197
Toxicity to various agents 67.58 10.79 418 122042 199944 34634527
Hospitalisation 67.38 10.79 60 122400 56842 34777629
Cardiac arrest 67.28 10.79 148 122312 96011 34738460
Renal tubular necrosis 67.11 10.79 161 122299 15519 34818952
Pneumomediastinum 67.05 10.79 60 122400 2307 34832164
Insomnia 67.04 10.79 167 122293 103740 34730731
Weight decreased 66.87 10.79 354 122106 175947 34658524
Vomiting 66.81 10.79 551 121909 247070 34587401
Vein rupture 66.75 10.79 41 122419 873 34833598
Aggression 65.79 10.79 27 122433 38937 34795534
Squamous cell carcinoma of skin 65.20 10.79 128 122332 10753 34823718
Mycobacterial infection 64.93 10.79 59 122401 2315 34832156
Unevaluable event 64.83 10.79 17 122443 32573 34801898
Wheezing 64.73 10.79 32 122428 41370 34793101
Lymphadenitis 64.68 10.79 55 122405 1973 34832498
Encephalitis cytomegalovirus 64.57 10.79 35 122425 583 34833888
Pneumonia fungal 64.04 10.79 100 122360 7000 34827471
Nausea 63.94 10.79 824 121636 339084 34495387
Complications of transplanted heart 63.57 10.79 28 122432 288 34834183
Rectal haemorrhage 63.09 10.79 31 122429 40218 34794253
Neuropathy peripheral 62.59 10.79 123 122337 83140 34751331
Hypokalaemia 62.43 10.79 67 122393 58147 34776324
Cardio-respiratory arrest 62.24 10.79 61 122399 55212 34779259
Erythrodermic psoriasis 61.98 10.79 39 122421 868 34833603
Basal cell carcinoma 61.86 10.79 180 122280 19478 34814993
Diarrhoea 61.82 10.79 978 121482 388934 34445537
Haemolytic uraemic syndrome 60.93 10.79 56 122404 2230 34832241
Hepatitis C 60.56 10.79 117 122343 9713 34824758
Cutaneous T-cell lymphoma 60.20 10.79 47 122413 1491 34832980
Cystitis viral 59.58 10.79 32 122428 523 34833948
Asthma 59.45 10.79 38 122422 42618 34791853
Acute myocardial infarction 58.53 10.79 61 122399 53658 34780813
Loss of consciousness 58.02 10.79 127 122333 82540 34751931
Sedation 57.96 10.79 4 122456 21002 34813469
C-reactive protein abnormal 57.79 10.79 107 122353 8603 34825868
Engraft failure 57.72 10.79 30 122430 457 34834014
Peripheral swelling 57.59 10.79 113 122347 76428 34758043
Psoriatic arthropathy 57.30 10.79 176 122284 19622 34814849
Chorioretinopathy 57.09 10.79 45 122415 1448 34833023
Pancytopenia 56.45 10.79 545 121915 94612 34739859
Tongue disorder 56.44 10.79 81 122379 5258 34829213
Pneumatosis intestinalis 56.09 10.79 69 122391 3854 34830617
Renal failure 55.53 10.79 700 121760 129857 34704614
Sepsis 55.47 10.79 855 121605 165706 34668765
Spermatozoa progressive motility decreased 55.22 10.79 20 122440 116 34834355
Cytomegalovirus colitis 55.17 10.79 58 122402 2726 34831745
Chest discomfort 54.95 10.79 66 122394 54464 34780007
Alveolar proteinosis 54.87 10.79 29 122431 458 34834013
Bacterial sepsis 54.55 10.79 79 122381 5171 34829300
Cryptococcosis 54.49 10.79 54 122406 2365 34832106
Serotonin syndrome 54.41 10.79 4 122456 19929 34814542
Hypersensitivity 54.19 10.79 383 122077 60652 34773819
Lactic acidosis 54.17 10.79 27 122433 34745 34799726
Viral test positive 53.70 10.79 22 122438 186 34834285
Blood glucose increased 53.28 10.79 95 122365 66623 34767848
American trypanosomiasis 52.43 10.79 23 122437 234 34834237
Stem cell transplant 52.40 10.79 50 122410 2089 34832382
Flushing 52.30 10.79 24 122436 32396 34802075
Nephrectomy 51.26 10.79 33 122427 765 34833706
Thrombotic thrombocytopenic purpura 51.00 10.79 61 122399 3309 34831162
Scleroderma 50.89 10.79 43 122417 1529 34832942
Skin lesion 50.83 10.79 181 122279 21780 34812691
Mycoplasma infection 50.68 10.79 26 122434 385 34834086
Escherichia infection 50.63 10.79 98 122362 8147 34826324
Pyogenic granuloma 50.62 10.79 23 122437 256 34834215
Drug level increased 50.20 10.79 181 122279 21915 34812556
Hallucination 50.14 10.79 64 122396 51434 34783037
Leukaemia recurrent 49.88 10.79 43 122417 1572 34832899
Therapeutic response decreased 48.85 10.79 218 122242 29095 34805376
Drug withdrawal syndrome 48.80 10.79 6 122454 19828 34814643
Palpitations 48.74 10.79 41 122419 39945 34794526
Ureteric stenosis 48.34 10.79 37 122423 1139 34833332
Stress 48.13 10.79 23 122437 30324 34804147
Drug reaction with eosinophilia and systemic symptoms 47.97 10.79 28 122432 32984 34801487
Encephalitis 47.78 10.79 89 122371 7188 34827283
Hypoaesthesia 47.71 10.79 89 122371 61355 34773116
Hypertrichosis 47.69 10.79 25 122435 388 34834083
Glomerulosclerosis 47.56 10.79 32 122428 801 34833670
Nephrotic syndrome 47.56 10.79 89 122371 7214 34827257
Bacillary angiomatosis 47.22 10.79 18 122442 123 34834348
Sebaceous hyperplasia 47.16 10.79 15 122445 54 34834417
Candida infection 47.15 10.79 153 122307 17562 34816909
Cardiac disorder 46.95 10.79 49 122411 43077 34791394
Lung infiltration 46.35 10.79 124 122336 12781 34821690
Haptoglobin decreased 45.67 10.79 27 122433 535 34833936
Disseminated tuberculosis 45.60 10.79 47 122413 2158 34832313
Acute respiratory distress syndrome 45.46 10.79 196 122264 25773 34808698
Alternaria infection 45.41 10.79 24 122436 379 34834092
Complications of transplant surgery 45.41 10.79 26 122434 484 34833987
Tachycardia 45.30 10.79 149 122311 84623 34749848
Aplastic anaemia 45.11 10.79 103 122357 9613 34824858
Osteonecrosis of jaw 45.04 10.79 5 122455 17884 34816587
Venous injury 45.01 10.79 22 122438 292 34834179
Microangiopathic haemolytic anaemia 44.93 10.79 32 122428 880 34833591
Toxoplasmosis 44.67 10.79 37 122423 1279 34833192
Erectile dysfunction 44.56 10.79 9 122451 20628 34813843
Hepatic fibrosis 44.52 10.79 67 122393 4540 34829931
Urinary retention 44.49 10.79 37 122423 36251 34798220
Diabetes mellitus 44.48 10.79 299 122161 46574 34787897
Synovitis 44.45 10.79 129 122331 13937 34820534
Bacteraemia 44.35 10.79 161 122299 19556 34814915
Deep vein thrombosis 44.34 10.79 102 122358 65146 34769325
Arthralgia 44.15 10.79 382 122078 169659 34664812
Coronary artery disease 44.02 10.79 63 122397 48242 34786229
Blood beta-D-glucan increased 44.00 10.79 24 122436 405 34834066
Steroid diabetes 43.98 10.79 46 122414 2149 34832322
Epstein-Barr virus associated lymphoma 43.84 10.79 28 122432 640 34833831
Chronic graft versus host disease in eye 43.72 10.79 16 122444 96 34834375
Actinic keratosis 43.54 10.79 66 122394 4501 34829970
Glomerulonephritis membranous 43.46 10.79 35 122425 1162 34833309
Heart rate decreased 43.26 10.79 29 122431 31716 34802755
Staphylococcal sepsis 43.12 10.79 102 122358 9742 34824729
Cytomegalovirus syndrome 43.04 10.79 16 122444 101 34834370
General physical health deterioration 42.98 10.79 268 122192 128001 34706470
Gait disturbance 42.55 10.79 154 122306 84986 34749485
Gastrooesophageal reflux disease 42.52 10.79 42 122418 37882 34796589
Lymphopenia 42.51 10.79 140 122320 16195 34818276
Ventricular tachycardia 42.37 10.79 20 122440 26559 34807912
Lymphocytic infiltration 42.10 10.79 28 122432 687 34833784
Feeling abnormal 42.05 10.79 100 122360 63135 34771336
Urticaria 41.90 10.79 367 122093 62010 34772461
Cerebral toxoplasmosis 41.73 10.79 40 122420 1681 34832790
Blood stem cell transplant failure 41.61 10.79 23 122437 399 34834072
Systemic candida 41.57 10.79 58 122402 3668 34830803
Blood lactate dehydrogenase increased 41.39 10.79 175 122285 22815 34811656
Trichophytic granuloma 41.27 10.79 13 122447 45 34834426
Encephalitis viral 40.98 10.79 34 122426 1178 34833293
Nasopharyngitis 40.92 10.79 118 122342 69850 34764621
Cushingoid 40.86 10.79 49 122411 2665 34831806
Chimerism 40.86 10.79 19 122441 224 34834247
Anaemia 40.74 10.79 574 121886 232761 34601710
Red blood cell schistocytes present 40.71 10.79 19 122441 226 34834245
Bronchiolitis obliterans syndrome 40.62 10.79 18 122442 188 34834283
Myopathy 40.47 10.79 110 122350 11444 34823027
Rhabdomyolysis 40.21 10.79 390 122070 67773 34766698
Cytokine release syndrome 40.02 10.79 15 122445 22862 34811609
Memory impairment 39.96 10.79 56 122404 43262 34791209
Septic shock 39.95 10.79 406 122054 71428 34763043
Respiratory depression 39.76 10.79 5 122455 16240 34818231
Joint swelling 39.59 10.79 95 122365 59795 34774676
Delirium 39.47 10.79 58 122402 43933 34790538
Biopsy kidney abnormal 39.29 10.79 15 122445 103 34834368
Adenoviral haemorrhagic cystitis 39.28 10.79 22 122438 392 34834079
Drug level changed 39.11 10.79 21 122439 343 34834128
Herpes virus infection 39.05 10.79 49 122411 2793 34831678
Scedosporium infection 39.03 10.79 29 122431 853 34833618
Systemic mycosis 38.97 10.79 37 122423 1536 34832935
Enterococcal sepsis 38.92 10.79 38 122422 1634 34832837
Encephalitis fungal 38.67 10.79 17 122443 174 34834297
Injection site erythema 38.66 10.79 5 122455 15894 34818577
Human herpesvirus 8 infection 38.60 10.79 30 122430 945 34833526
Serum sickness 38.45 10.79 41 122419 1959 34832512
Instillation site pain 38.26 10.79 14 122446 84 34834387
Meningoencephalitis herpetic 38.18 10.79 28 122432 807 34833664
Fusarium infection 38.10 10.79 32 122428 1128 34833343
Wrong technique in product usage process 37.93 10.79 42 122418 35944 34798527
Drug dependence 37.43 10.79 19 122441 24198 34810273
Head injury 37.03 10.79 9 122451 18151 34816320
Klebsiella infection 36.94 10.79 88 122372 8443 34826028
Prostate cancer 36.83 10.79 51 122409 39598 34794873
Enterobacter infection 36.79 10.79 44 122416 2386 34832085
Renal lymphocele 36.55 10.79 12 122448 49 34834422
Urine output decreased 36.54 10.79 97 122363 9952 34824519
Dysgeusia 36.38 10.79 24 122436 26473 34807998
Immunosuppression 36.37 10.79 73 122387 6231 34828240
Self-consciousness 36.36 10.79 12 122448 50 34834421
Renal disorder 36.25 10.79 181 122279 25299 34809172
Poikiloderma 36.03 10.79 16 122444 168 34834303
Smooth muscle cell neoplasm 35.95 10.79 16 122444 169 34834302
Renal transplant 35.71 10.79 38 122422 1811 34832660
Laparotomy 35.40 10.79 19 122441 310 34834161
Brain stem syndrome 35.39 10.79 23 122437 542 34833929
Brain abscess 35.39 10.79 49 122411 3076 34831395
Incorrect route of product administration 35.30 10.79 5 122455 14840 34819631
Heart rate increased 35.21 10.79 68 122392 46275 34788196
Diabetic ketoacidosis 34.75 10.79 10 122450 18022 34816449
Hypocalcaemia 34.72 10.79 21 122439 24268 34810203
Adverse drug reaction 34.65 10.79 31 122429 29311 34805160
Dermatitis exfoliative generalised 34.53 10.79 53 122407 3654 34830817
Human polyomavirus infection 34.13 10.79 25 122435 719 34833752
Ventricular fibrillation 34.02 10.79 19 122441 22935 34811536
Lactobacillus infection 33.85 10.79 18 122442 288 34834183
Thymus hypoplasia 33.75 10.79 20 122440 398 34834073
Lymphoid tissue hypoplasia 33.75 10.79 20 122440 398 34834073
Corneal endotheliitis 33.68 10.79 11 122449 44 34834427
Orthostatic hypotension 33.57 10.79 25 122435 25894 34808577
Contusion 33.55 10.79 47 122413 36317 34798154
Plasma cell myeloma 33.42 10.79 60 122400 41977 34792494
Papilloma viral infection 33.23 10.79 21 122439 471 34834000
Glomerulonephropathy 33.03 10.79 16 122444 208 34834263
Tularaemia 33.01 10.79 13 122447 98 34834373
Bone marrow failure 32.97 10.79 195 122265 29058 34805413
Transient ischaemic attack 32.82 10.79 29 122431 27584 34806887
Endoscopic retrograde cholangiopancreatography 32.81 10.79 8 122452 6 34834465
Oxygen saturation decreased 32.77 10.79 89 122371 53729 34780742
Abdominal pain upper 32.70 10.79 134 122326 71356 34763115
Blood urea increased 32.68 10.79 200 122260 30164 34804307
Atypical mycobacterial pneumonia 32.66 10.79 14 122446 134 34834337
Growth retardation 32.24 10.79 36 122424 1812 34832659
Pustular psoriasis 32.11 10.79 34 122426 1611 34832860
Eye pain 32.05 10.79 112 122348 13350 34821121
Mechanical ventilation 32.04 10.79 37 122423 1933 34832538
Injection site papule 32.02 10.79 18 122442 323 34834148
Glomerulonephritis 31.91 10.79 37 122423 1941 34832530
Acute lymphocytic leukaemia recurrent 31.91 10.79 46 122414 2998 34831473
Tumour lysis syndrome 31.89 10.79 10 122450 17049 34817422
Blood pressure fluctuation 31.88 10.79 25 122435 25224 34809247
Skin necrosis 31.67 10.79 66 122394 5787 34828684
Off label use 31.66 10.79 1783 120677 417741 34416730
Hyperplasia 31.63 10.79 22 122438 582 34833889
Chronic myeloid leukaemia 31.61 10.79 39 122421 2185 34832286
Oliguria 31.60 10.79 82 122378 8298 34826173
Unresponsive to stimuli 31.52 10.79 30 122430 27539 34806932
Infection 31.48 10.79 470 121990 90445 34744026
Epstein-Barr virus antibody positive 31.32 10.79 17 122443 284 34834187
Varicella zoster virus infection 31.20 10.79 35 122425 1771 34832700
Hepatic enzyme increased 31.11 10.79 239 122221 38841 34795630
Achromobacter infection 31.08 10.79 11 122449 59 34834412
Lymphadenopathy 30.97 10.79 188 122272 28275 34806196
Disseminated aspergillosis 30.88 10.79 24 122436 756 34833715
Life support 30.88 10.79 14 122446 155 34834316
Alanine aminotransferase increased 30.85 10.79 425 122035 80390 34754081
Plasmablastic lymphoma 30.79 10.79 18 122442 349 34834122
Cough 30.75 10.79 357 122103 149783 34684688
Anuria 30.68 10.79 93 122367 10292 34824179
Foreign body sensation in eyes 30.67 10.79 22 122438 612 34833859
C-reactive protein increased 30.66 10.79 307 122153 53791 34780680
Eosinophilia 30.61 10.79 28 122432 26194 34808277
Haematochezia 30.61 10.79 74 122386 46460 34788011
Prostatic specific antigen increased 30.48 10.79 7 122453 14673 34819798
Adverse event 30.41 10.79 14 122446 18863 34815608
Behcet's syndrome 30.38 10.79 8 122452 11 34834460
Diffuse alveolar damage 30.38 10.79 39 122421 2275 34832196
Respiratory arrest 30.36 10.79 32 122428 28011 34806460
Skin mass 30.35 10.79 52 122408 3933 34830538
Legionella infection 30.35 10.79 20 122440 483 34833988
Reticulocyte count increased 30.34 10.79 21 122439 551 34833920
Hepatic cancer recurrent 30.20 10.79 17 122443 306 34834165
Respiratory tract infection fungal 30.16 10.79 23 122437 704 34833767
Paraesthesia 30.15 10.79 119 122341 64053 34770418
Skin papilloma 30.09 10.79 37 122423 2066 34832405
Heart rate irregular 30.03 10.79 9 122451 15798 34818673
Blood pressure decreased 30.02 10.79 87 122373 51428 34783043
Aplasia 29.98 10.79 56 122404 4532 34829939
Hypersomnia 29.93 10.79 4 122456 12403 34822068
Myopathy toxic 29.89 10.79 21 122439 565 34833906
Sleep apnoea syndrome 29.85 10.79 17 122443 20304 34814167
Dyskinesia 29.84 10.79 21 122439 22392 34812079
Blindness cortical 29.65 10.79 18 122442 375 34834096
Nightmare 29.60 10.79 7 122453 14384 34820087
Renal vessel disorder 29.48 10.79 15 122445 218 34834253
Serum ferritin increased 29.47 10.79 66 122394 6080 34828391
Abdominal discomfort 29.38 10.79 109 122351 59726 34774745
Papilloma 29.33 10.79 16 122444 270 34834201
Mass excision 29.29 10.79 9 122451 28 34834443
Removal of renal transplant 29.06 10.79 9 122451 29 34834442
Central nervous system fungal infection 28.93 10.79 17 122443 333 34834138
Appendicitis 28.93 10.79 8 122452 14799 34819672
Apoptosis 28.91 10.79 18 122442 393 34834078
Cutaneous mucormycosis 28.90 10.79 14 122446 182 34834289
Complications of transplanted liver 28.89 10.79 15 122445 228 34834243
Pneumonia aspiration 28.87 10.79 65 122395 41838 34792633
Leukopenia 28.84 10.79 342 122118 62514 34771957
Drug hypersensitivity 28.67 10.79 165 122295 80364 34754107
Laboratory test abnormal 28.63 10.79 18 122442 20373 34814098
Iron overload 28.63 10.79 29 122431 1304 34833167
Abdominal distension 28.43 10.79 107 122353 58385 34776086
Skin injury 28.42 10.79 38 122422 2307 34832164
Panniculitis 28.39 10.79 35 122425 1959 34832512
Haemosiderosis 28.32 10.79 16 122444 290 34834181
Granuloma 28.23 10.79 45 122415 3206 34831265
Hydronephrosis 28.11 10.79 90 122370 10256 34824215
Osteonecrosis 28.09 10.79 115 122345 14775 34819696
Atypical mycobacterial infection 28.03 10.79 24 122436 869 34833602
Foetal exposure during pregnancy 28.00 10.79 57 122403 38044 34796427
Nephropathy 27.77 10.79 63 122397 5854 34828617
Pneumonia adenoviral 27.76 10.79 17 122443 360 34834111
Intentional self-injury 27.74 10.79 7 122453 13764 34820707
Red blood cell sedimentation rate 27.65 10.79 27 122433 1161 34833310
Abnormal behaviour 27.59 10.79 28 122432 24941 34809530
Glomerulonephritis membranoproliferative 27.56 10.79 18 122442 428 34834043
Erythema infectiosum 27.53 10.79 13 122447 159 34834312
Lepromatous leprosy 27.47 10.79 10 122450 59 34834412
Philadelphia positive chronic myeloid leukaemia 27.45 10.79 12 122448 121 34834350
Respiratory failure 27.30 10.79 533 121927 108039 34726432
Acinetobacter infection 27.29 10.79 27 122433 1180 34833291
Dyspepsia 26.95 10.79 55 122405 36677 34797794
Osmotic demyelination syndrome 26.88 10.79 23 122437 832 34833639
Cutaneous sporotrichosis 26.81 10.79 9 122451 40 34834431
Porokeratosis 26.75 10.79 11 122449 94 34834377
Opportunistic infection 26.73 10.79 31 122429 1627 34832844
Pyelonephritis chronic 26.63 10.79 9 122451 41 34834430
Bronchitis 26.60 10.79 68 122392 41895 34792576
Toxic leukoencephalopathy 26.60 10.79 17 122443 389 34834082
Plasmacytoma 26.59 10.79 47 122413 3644 34830827
Idiopathic intracranial hypertension 26.53 10.79 21 122439 680 34833791
Incisional drainage 26.45 10.79 11 122449 97 34834374
Nephrolithiasis 26.23 10.79 41 122419 30292 34804179
Dysphonia 26.09 10.79 26 122434 23357 34811114
Skin laceration 25.90 10.79 6 122454 12503 34821968
Autoimmune haemolytic anaemia 25.86 10.79 52 122408 4444 34830027
White blood cell count decreased 25.83 10.79 212 122248 95233 34739238
B-cell lymphoma 25.74 10.79 51 122409 4312 34830159
Bowen's disease 25.69 10.79 12 122448 143 34834328
Vertigo 25.62 10.79 31 122429 25505 34808966
Flatulence 25.51 10.79 22 122438 21176 34813295
Pallor 25.49 10.79 31 122429 25449 34809022
Trichophytosis 25.47 10.79 15 122445 295 34834176
Cytomegalovirus enteritis 25.46 10.79 18 122442 489 34833982
Tremor 25.40 10.79 177 122283 82410 34752061
Sweat gland tumour 25.39 10.79 17 122443 422 34834049
Sinus bradycardia 25.33 10.79 7 122453 12956 34821515
Tendonitis 25.28 10.79 80 122380 9060 34825411
Treatment noncompliance 25.25 10.79 37 122423 28063 34806408
Bone marrow transplant rejection 25.25 10.79 13 122447 194 34834277
Presyncope 25.18 10.79 18 122442 19041 34815430
Papule 25.17 10.79 49 122411 4090 34830381
Hepatitis B 25.13 10.79 61 122399 5922 34828549
Lung lobectomy 25.11 10.79 8 122452 29 34834442
Road traffic accident 25.07 10.79 15 122445 17435 34817036
Pulmonary tuberculosis 25.01 10.79 53 122407 4701 34829770
Glomerulonephritis proliferative 25.01 10.79 13 122447 198 34834273
Hypertensive encephalopathy 24.96 10.79 16 122444 368 34834103
Renal arteriosclerosis 24.96 10.79 13 122447 199 34834272
Laser therapy 24.90 10.79 6 122454 4 34834467
Haemorrhagic cyst 24.88 10.79 10 122450 80 34834391
Keratitis 24.86 10.79 28 122432 1423 34833048
Swollen tongue 24.85 10.79 10 122450 14595 34819876
Pulmonary haemorrhage 24.77 10.79 86 122374 10218 34824253
Angina pectoris 24.72 10.79 45 122415 31318 34803153
Microangiopathy 24.71 10.79 23 122437 931 34833540
Fungal sepsis 24.67 10.79 22 122438 842 34833629
Complications of transplanted lung 24.61 10.79 13 122447 205 34834266
Cytomegalovirus hepatitis 24.57 10.79 17 122443 446 34834025
Pneumonia pseudomonal 24.55 10.79 47 122413 3875 34830596
Phototherapy 24.50 10.79 8 122452 32 34834439
Mycobacterium kansasii infection 24.48 10.79 15 122445 318 34834153
Acute disseminated encephalomyelitis 24.46 10.79 10 122450 84 34834387
Swelling face 24.31 10.79 27 122433 23078 34811393
Escherichia sepsis 24.24 10.79 52 122408 4652 34829819
Respiratory syncytial virus infection 24.20 10.79 52 122408 4657 34829814
Candida sepsis 24.20 10.79 26 122434 1253 34833218
Granuloma skin 24.20 10.79 26 122434 1253 34833218
Infection reactivation 24.13 10.79 28 122432 1470 34833001
Small intestinal obstruction 23.98 10.79 11 122449 14855 34819616
Fungal test positive 23.92 10.79 18 122442 540 34833931
Cytomegalovirus gastrointestinal infection 23.91 10.79 13 122447 218 34834253
Debridement 23.83 10.79 22 122438 881 34833590
Cerebral fungal infection 23.65 10.79 14 122446 278 34834193
Sleep disorder 23.63 10.79 47 122413 31641 34802830
Transaminases increased 23.60 10.79 168 122292 26655 34807816
Hepatitis B reactivation 23.59 10.79 46 122414 3845 34830626
Lethargy 23.56 10.79 70 122390 41052 34793419
Hyperkeratosis 23.56 10.79 45 122415 3704 34830767
Post transplant distal limb syndrome 23.52 10.79 14 122446 281 34834190
Disturbance in attention 23.47 10.79 34 122426 25911 34808560
Sporotrichosis 23.30 10.79 9 122451 64 34834407
Aspartate aminotransferase increased 23.29 10.79 350 122110 67433 34767038
Ulcer 23.23 10.79 76 122384 8759 34825712
Dry mouth 23.14 10.79 44 122416 30121 34804350
Injury 23.08 10.79 23 122437 20664 34813807
Lung abscess 23.08 10.79 37 122423 2648 34831823
Drug level fluctuating 22.94 10.79 17 122443 498 34833973
Full blood count abnormal 22.92 10.79 19 122441 18649 34815822
Dystonia 22.86 10.79 5 122455 10840 34823631
Lip swelling 22.85 10.79 14 122446 16066 34818405
Papilloedema 22.80 10.79 37 122423 2676 34831795
Blood parathyroid hormone decreased 22.74 10.79 27 122433 1453 34833018
Phaeohyphomycosis 22.71 10.79 21 122439 843 34833628
Irritability 22.69 10.79 32 122428 24658 34809813
Hot flush 22.67 10.79 18 122442 18048 34816423
Product quality issue 22.62 10.79 16 122444 17019 34817452
Infective tenosynovitis 22.61 10.79 9 122451 70 34834401
Neutrophil count decreased 22.61 10.79 97 122363 51007 34783464
Coma 22.56 10.79 83 122377 45595 34788876
Hand deformity 22.53 10.79 44 122416 3681 34830790
Disseminated cryptococcosis 22.49 10.79 26 122434 1360 34833111
Restlessness 22.46 10.79 34 122426 25448 34809023
Oesophageal squamous cell carcinoma 22.41 10.79 15 122445 372 34834099
Thrombosis 22.19 10.79 96 122364 50362 34784109
Anger 22.16 10.79 7 122453 11877 34822594
Intentional product use issue 22.13 10.79 121 122339 59695 34774776
Pneumocystis jirovecii infection 21.94 10.79 29 122431 1741 34832730
Diffuse large B-cell lymphoma stage IV 21.88 10.79 13 122447 260 34834211
Hypercholesterolaemia 21.82 10.79 74 122386 8688 34825783
NPM1 gene mutation 21.65 10.79 10 122450 116 34834355
Varicella 21.60 10.79 28 122432 1649 34832822
Reticulocytosis 21.58 10.79 13 122447 267 34834204
CSF protein increased 21.56 10.79 20 122440 806 34833665
Fungaemia 21.55 10.79 35 122425 2533 34831938
Full blood count decreased 21.49 10.79 19 122441 18069 34816402
Pruritus 21.41 10.79 359 122101 141622 34692849
Glomerulonephritis minimal lesion 21.41 10.79 16 122444 475 34833996
Acanthamoeba infection 21.33 10.79 15 122445 404 34834067
Epstein-Barr virus test positive 21.33 10.79 17 122443 556 34833915
West Nile viral infection 21.29 10.79 19 122441 728 34833743
Therapy cessation 21.18 10.79 17 122443 16956 34817515
Blood potassium decreased 21.07 10.79 19 122441 17896 34816575
Infection in an immunocompromised host 21.04 10.79 18 122442 651 34833820
Leukoencephalopathy 21.04 10.79 46 122414 4169 34830302
Pathogen resistance 20.96 10.79 77 122383 9405 34825066
Depressed mood 20.96 10.79 22 122438 19295 34815176
Perinephric collection 20.91 10.79 11 122449 172 34834299
Limb deformity 20.84 10.79 17 122443 575 34833896
Malabsorption 20.82 10.79 33 122427 2339 34832132
Therapy interrupted 20.79 10.79 11 122449 13686 34820785
Biliary hamartoma 20.77 10.79 6 122454 14 34834457
Accidental overdose 20.68 10.79 24 122436 20116 34814355
Haematoma evacuation 20.58 10.79 11 122449 178 34834293
Arteriosclerosis coronary artery 20.51 10.79 9 122451 12476 34821995
Productive cough 20.50 10.79 66 122394 37747 34796724
Pain in jaw 20.50 10.79 10 122450 13030 34821441
Epistaxis 20.49 10.79 302 122158 57949 34776522
Schizophrenia 20.42 10.79 3 122457 8663 34825808
Anaplastic large cell lymphoma T- and null-cell types 20.40 10.79 9 122451 93 34834378
Neuroendocrine carcinoma of the skin 20.35 10.79 19 122441 772 34833699
Visceral leishmaniasis 20.35 10.79 17 122443 595 34833876
Subdural haematoma 20.26 10.79 25 122435 20396 34814075
Cardiogenic shock 20.26 10.79 39 122421 26579 34807892
Hepatosplenomegaly 20.25 10.79 45 122415 4124 34830347
Klebsiella sepsis 20.22 10.79 30 122430 2007 34832464
Graft complication 20.21 10.79 14 122446 368 34834103
Cytogenetic abnormality 20.20 10.79 20 122440 875 34833596
Bile duct stenosis 20.12 10.79 23 122437 1188 34833283
Musculoskeletal pain 20.10 10.79 52 122408 31911 34802560
Dysarthria 20.08 10.79 59 122401 34723 34799748
Extrapyramidal disorder 20.06 10.79 10 122450 12870 34821601
Paroxysmal nocturnal haemoglobinuria 20.02 10.79 7 122453 36 34834435
Malacoplakia 20.02 10.79 15 122445 447 34834024
Uveitis 19.98 10.79 65 122395 7470 34827001
Pulmonary nocardiosis 19.95 10.79 20 122440 888 34833583
Scleral hyperaemia 19.91 10.79 8 122452 64 34834407
Wound dehiscence 19.90 10.79 39 122421 3272 34831199
Fear 19.84 10.79 6 122454 10470 34824001
Rib fracture 19.82 10.79 13 122447 14387 34820084
Upper gastrointestinal haemorrhage 19.77 10.79 37 122423 25481 34808990
Neoplasm skin 19.75 10.79 19 122441 802 34833669
Hepatotoxicity 19.74 10.79 136 122324 21349 34813122
Gastroenteritis rotavirus 19.74 10.79 11 122449 194 34834277
Abdominal pain 19.68 10.79 430 122030 163188 34671283
Device issue 19.63 10.79 5 122455 9772 34824699
Dry skin 19.60 10.79 51 122409 31236 34803235
Endotracheal intubation 19.52 10.79 37 122423 3028 34831443
Papillary renal cell carcinoma 19.52 10.79 12 122448 256 34834215
Lower respiratory tract infection 19.49 10.79 52 122408 31585 34802886
Oligospermia 19.44 10.79 9 122451 105 34834366
Cardiac failure 19.43 10.79 215 122245 91033 34743438
Retinopathy haemorrhagic 19.41 10.79 7 122453 40 34834431
CSF cell count increased 19.41 10.79 7 122453 40 34834431
Adenomatous polyposis coli 19.38 10.79 10 122450 150 34834321
Drug level decreased 19.31 10.79 66 122394 7780 34826691
Product use issue 19.29 10.79 320 122140 62896 34771575
Metabolic acidosis 19.27 10.79 83 122377 43597 34790874
Marrow hyperplasia 19.18 10.79 22 122438 1141 34833330
Parvovirus B19 infection 19.10 10.79 19 122441 836 34833635
Dysphagia 19.02 10.79 134 122326 62247 34772224
Nephrosclerosis 19.01 10.79 20 122440 941 34833530
Refractoriness to platelet transfusion 19.00 10.79 8 122452 73 34834398
Plasmodium falciparum infection 18.99 10.79 7 122453 43 34834428
Generalised oedema 18.98 10.79 90 122370 12318 34822153
Influenza like illness 18.92 10.79 43 122417 27591 34806880
Pneumonia influenzal 18.89 10.79 25 122435 1503 34832968
Umbilical hernia repair 18.78 10.79 6 122454 22 34834449
Benign prostatic hyperplasia 18.75 10.79 14 122446 14481 34819990
Disseminated toxoplasmosis 18.72 10.79 8 122452 76 34834395
Cancer surgery 18.65 10.79 15 122445 497 34833974
Undifferentiated sarcoma 18.63 10.79 4 122456 0 34834471
Citrobacter infection 18.63 10.79 15 122445 498 34833973
Necrosis 18.58 10.79 53 122407 5670 34828801
Disseminated varicella zoster vaccine virus infection 18.47 10.79 7 122453 47 34834424
Herpes zoster 18.43 10.79 193 122267 34206 34800265
Mycobacterium marinum infection 18.38 10.79 12 122448 285 34834186
Malignant sweat gland neoplasm 18.37 10.79 6 122454 24 34834447
Joint ankylosis 18.33 10.79 25 122435 1547 34832924
Haematemesis 18.27 10.79 44 122416 27667 34806804
Microsporidia infection 18.25 10.79 17 122443 689 34833782
Acanthosis 18.24 10.79 9 122451 122 34834349
Rhinovirus infection 18.24 10.79 44 122416 4255 34830216
Salivary hypersecretion 18.19 10.79 4 122456 8640 34825831
Myasthenic syndrome 18.17 10.79 15 122445 516 34833955
Stent removal 18.17 10.79 5 122455 9 34834462
Cutaneous T-cell lymphoma stage I 18.17 10.79 5 122455 9 34834462
Anti-cyclic citrullinated peptide antibody positive 18.09 10.79 27 122433 1816 34832655
Pneumonia bacterial 18.08 10.79 86 122374 11786 34822685
Cat scratch disease 18.06 10.79 10 122450 174 34834297
Blood immunoglobulin G decreased 18.05 10.79 24 122436 1449 34833022
Pseudomonal sepsis 18.04 10.79 39 122421 3508 34830963
Mycobacterium chelonae infection 18.00 10.79 18 122442 797 34833674
Meningococcal sepsis 17.99 10.79 6 122454 26 34834445
Bone cyst 17.99 10.79 25 122435 1575 34832896
Fungal endocarditis 17.96 10.79 13 122447 367 34834104
Splenic abscess 17.90 10.79 13 122447 369 34834102
Mycobacterium abscessus infection 17.85 10.79 15 122445 529 34833942
Urinary incontinence 17.80 10.79 24 122436 18850 34815621
Arterial disorder 17.77 10.79 22 122438 1237 34833234
Upper respiratory tract inflammation 17.77 10.79 26 122434 1718 34832753
Intestinal obstruction 17.76 10.79 33 122427 22789 34811682
IgA nephropathy 17.71 10.79 22 122438 1241 34833230
Haemorrhoids 17.69 10.79 15 122445 14560 34819911
Trichosporon infection 17.68 10.79 17 122443 717 34833754
Ageusia 17.63 10.79 7 122453 10301 34824170
Drug intolerance 17.61 10.79 300 122160 59270 34775201
Cryptococcal cutaneous infection 17.53 10.79 8 122452 90 34834381
Troponin increased 17.50 10.79 9 122451 11380 34823091
Macule 17.50 10.79 24 122436 1493 34832978
Interleukin-2 receptor increased 17.50 10.79 9 122451 134 34834337
Sinus tachycardia 17.49 10.79 21 122439 17339 34817132
Keratoacanthoma 17.47 10.79 16 122444 634 34833837
Dyspnoea exertional 17.44 10.79 85 122375 43194 34791277
Toxic encephalopathy 17.42 10.79 49 122411 5200 34829271
Squamous cell carcinoma of the tongue 17.40 10.79 12 122448 313 34834158
Central nervous system lesion 17.36 10.79 56 122404 6407 34828064
Hyperfibrinogenaemia 17.31 10.79 7 122453 57 34834414
Retinitis 17.30 10.79 13 122447 389 34834082
Disseminated Bacillus Calmette-Guerin infection 17.29 10.79 10 122450 190 34834281
Pneumoretroperitoneum 17.26 10.79 9 122451 138 34834333
Organising pneumonia 17.15 10.79 53 122407 5926 34828545
Oedema peripheral 17.08 10.79 306 122154 119506 34714965
Skin neoplasm excision 17.02 10.79 13 122447 399 34834072
Ureteritis 16.93 10.79 5 122455 13 34834458
Hair follicle tumour benign 16.93 10.79 5 122455 13 34834458
Post procedural urine leak 16.92 10.79 9 122451 144 34834327
Neurological symptom 16.87 10.79 42 122418 4143 34830328
Meningeal neoplasm 16.80 10.79 7 122453 62 34834409
Hepatitis viral 16.73 10.79 15 122445 578 34833893
Gouty tophus 16.71 10.79 9 122451 148 34834323
Epstein-Barr virus antigen positive 16.68 10.79 6 122454 34 34834437
Botryomycosis 16.68 10.79 6 122454 34 34834437
Rheumatoid arthritis 16.66 10.79 73 122387 38165 34796306
Rebound effect 16.65 10.79 36 122424 3238 34831233
Tinnitus 16.64 10.79 28 122432 20090 34814381
Osteoporosis 16.63 10.79 88 122372 12580 34821891
Disorientation 16.59 10.79 60 122400 33128 34801343
Pityriasis rubra pilaris 16.58 10.79 8 122452 103 34834368
Disseminated intravascular coagulation 16.57 10.79 132 122328 21684 34812787
Inappropriate schedule of product administration 16.56 10.79 139 122321 62157 34772314
Musculoskeletal chest pain 16.53 10.79 7 122453 9911 34824560
Hypophosphataemia 16.52 10.79 9 122451 11017 34823454
Infertility 16.44 10.79 10 122450 209 34834262
Hodgkin's disease mixed cellularity stage unspecified 16.40 10.79 4 122456 3 34834468
Intra-aortic balloon placement 16.40 10.79 4 122456 3 34834468
Urethral dilatation 16.40 10.79 4 122456 3 34834468
Hippocampal sclerosis 16.38 10.79 8 122452 106 34834365
Cholangitis 16.31 10.79 67 122393 8622 34825849
Palatal ulcer 16.26 10.79 6 122454 37 34834434
Gammopathy 16.15 10.79 7 122453 69 34834402
Product container issue 16.10 10.79 16 122444 703 34833768
Abdominal wall abscess 16.07 10.79 14 122446 519 34833952
Thoracotomy 16.06 10.79 7 122453 70 34834401
Bacillus infection 16.05 10.79 11 122449 284 34834187
Fungal abscess central nervous system 15.99 10.79 8 122452 112 34834359
Ureaplasma infection 15.97 10.79 12 122448 359 34834112
Tongue ulceration 15.96 10.79 21 122439 1255 34833216
Abscess drainage 15.95 10.79 11 122449 287 34834184
Human ehrlichiosis 15.95 10.79 12 122448 360 34834111
Ureteric dilatation 15.89 10.79 9 122451 164 34834307
Angioedema 15.89 10.79 72 122388 37302 34797169
Urinoma 15.83 10.79 10 122450 224 34834247
Vascular graft complication 15.80 10.79 8 122452 115 34834356
Pulmonary alveolar haemorrhage 15.77 10.79 60 122400 7452 34827019
Oral herpes 15.76 10.79 49 122411 5498 34828973
Gynaecomastia 15.71 10.79 8 122452 10172 34824299
Pollakiuria 15.71 10.79 28 122432 19646 34814825
Taste disorder 15.70 10.79 3 122457 7152 34827319
Superficial injury of eye 15.62 10.79 6 122454 42 34834429
Passenger lymphocyte syndrome 15.62 10.79 6 122454 42 34834429
Limb injury 15.49 10.79 11 122449 11678 34822793
Blood pressure systolic increased 15.49 10.79 36 122424 22916 34811555
Oral disorder 15.43 10.79 41 122419 4208 34830263
Peripheral T-cell lymphoma unspecified 15.41 10.79 13 122447 461 34834010
Gastrointestinal infection 15.36 10.79 50 122410 5748 34828723
Supraventricular tachycardia 15.35 10.79 10 122450 11107 34823364
Pneumonia klebsiella 15.33 10.79 35 122425 3265 34831206
Subacute sclerosing panencephalitis 15.31 10.79 5 122455 20 34834451
CSF pressure increased 15.31 10.79 5 122455 20 34834451
Retinal scar 15.30 10.79 11 122449 307 34834164
Spindle cell sarcoma 15.10 10.79 8 122452 127 34834344
Red blood cell abnormality 15.07 10.79 12 122448 392 34834079
Rotavirus infection 15.04 10.79 12 122448 393 34834078
Ureteric anastomosis complication 15.04 10.79 6 122454 47 34834424
Ureteric obstruction 15.04 10.79 20 122440 1208 34833263
Impaired work ability 15.01 10.79 3 122457 6927 34827544
Skin cancer metastatic 14.99 10.79 4 122456 6 34834465
Dermatitis atopic 14.97 10.79 47 122413 5300 34829171
Ophthalmic herpes simplex 14.94 10.79 11 122449 319 34834152
Cholestasis 14.82 10.79 152 122308 26796 34807675
Hip fracture 14.81 10.79 12 122448 11913 34822558
Tuberculoma of central nervous system 14.73 10.79 10 122450 254 34834217
Hemianopia 14.73 10.79 15 122445 679 34833792
Interleukin level increased 14.72 10.79 8 122452 134 34834337
Nerve conduction studies abnormal 14.72 10.79 6 122454 50 34834421
Abdominal hernia repair 14.72 10.79 6 122454 50 34834421
Arrhythmia 14.62 10.79 70 122390 35738 34798733
Middle insomnia 14.61 10.79 3 122457 6799 34827672
Subcapsular renal haematoma 14.56 10.79 12 122448 412 34834059
Gastroenteritis cryptosporidial 14.55 10.79 9 122451 194 34834277
Pseudomembranous colitis 14.55 10.79 31 122429 2760 34831711
Blood pressure increased 14.53 10.79 219 122241 87883 34746588
Malignant melanoma stage I 14.52 10.79 7 122453 90 34834381
Enterocolitis viral 14.52 10.79 7 122453 90 34834381
Autoinflammatory disease 14.52 10.79 6 122454 52 34834419
Influenza 14.51 10.79 108 122352 49558 34784913
Non-Hodgkin's lymphoma 14.48 10.79 22 122438 1503 34832968
Haematotoxicity 14.45 10.79 62 122398 8132 34826339
Urinary bladder toxicity 14.42 10.79 5 122455 25 34834446
Total cholesterol/HDL ratio decreased 14.42 10.79 6 122454 53 34834418
Nasopharyngeal cancer 14.31 10.79 8 122452 142 34834329
Osteoarthritis 14.23 10.79 32 122428 20610 34813861
Seasonal allergy 14.23 10.79 3 122457 6672 34827799
Osteolysis 14.20 10.79 33 122427 3115 34831356
Diarrhoea haemorrhagic 14.18 10.79 54 122406 6710 34827761
Feeling cold 14.12 10.79 10 122450 10629 34823842
Renal tubular disorder 14.11 10.79 42 122418 4601 34829870
Limbic encephalitis 14.10 10.79 12 122448 431 34834040
Mitral valve incompetence 14.10 10.79 19 122441 14924 34819547
Concomitant disease aggravated 14.07 10.79 48 122412 5653 34828818
Chest expansion decreased 14.06 10.79 8 122452 147 34834324
Gingivectomy 13.97 10.79 3 122457 0 34834471
Peripheral artery dissection 13.97 10.79 3 122457 0 34834471
Bence Jones protein urine present 13.97 10.79 3 122457 0 34834471
Ureteral stent removal 13.97 10.79 3 122457 0 34834471
Transplant abscess 13.97 10.79 3 122457 0 34834471
Hepatitis B e antigen 13.97 10.79 3 122457 0 34834471
Ureteric repair 13.97 10.79 3 122457 0 34834471
Renal cell carcinoma stage II 13.97 10.79 3 122457 0 34834471
Primary mediastinal large B-cell lymphoma 13.97 10.79 3 122457 0 34834471
Cyst drainage 13.97 10.79 3 122457 0 34834471
Bacterial abdominal infection 13.97 10.79 3 122457 0 34834471
Hair growth rate abnormal 13.97 10.79 3 122457 0 34834471
Good syndrome 13.97 10.79 3 122457 0 34834471
Acute graft versus host disease oral 13.97 10.79 3 122457 0 34834471
Periorbital infection 13.97 10.79 8 122452 149 34834322
Explorative laparotomy 13.95 10.79 5 122455 28 34834443
Paranoia 13.95 10.79 13 122447 12055 34822416
Neck pain 13.91 10.79 44 122416 25305 34809166
Nephrogenic diabetes insipidus 13.90 10.79 20 122440 1301 34833170
Ventricular extrasystoles 13.80 10.79 13 122447 11995 34822476
Throat tightness 13.77 10.79 6 122454 8352 34826119
Cold sweat 13.77 10.79 9 122451 9978 34824493
Cutaneous tuberculosis 13.74 10.79 7 122453 102 34834369
Acid fast bacilli infection 13.74 10.79 7 122453 102 34834369
Mantle cell lymphoma stage IV 13.68 10.79 6 122454 61 34834410
Sudden death 13.67 10.79 20 122440 15181 34819290
Colitis 13.61 10.79 77 122383 37673 34796798
Viral infection 13.59 10.79 107 122353 17516 34816955
Gastrointestinal stromal tumour 13.57 10.79 17 122443 967 34833504
Device malfunction 13.56 10.79 10 122450 10411 34824060
Pigmentation disorder 13.54 10.79 28 122432 2441 34832030
Urinary tract infection enterococcal 13.54 10.79 16 122444 857 34833614
Viral uveitis 13.53 10.79 5 122455 31 34834440
Urinary tract infection viral 13.53 10.79 5 122455 31 34834440
Nephrostomy 13.53 10.79 9 122451 221 34834250
Toxic skin eruption 13.47 10.79 12 122448 11373 34823098
Viral myocarditis 13.42 10.79 8 122452 161 34834310
Musculoskeletal stiffness 13.40 10.79 102 122358 46578 34787893
Corneal graft rejection 13.39 10.79 5 122455 32 34834439
Neuroendocrine tumour of the lung metastatic 13.39 10.79 7 122453 108 34834363
Bronchitis bacterial 13.36 10.79 15 122445 760 34833711
Pyelonephritis 13.35 10.79 50 122410 6165 34828306
Cyanosis 13.33 10.79 15 122445 12749 34821722
Product administration error 13.28 10.79 23 122437 16321 34818150
Haemolytic anaemia 13.22 10.79 72 122388 10407 34824064
Cryptosporidiosis infection 13.14 10.79 12 122448 474 34833997
Rhinorrhoea 13.10 10.79 46 122414 25622 34808849
Gastroenteritis norovirus 13.08 10.79 21 122439 1505 34832966
Renal hypertension 13.08 10.79 8 122452 169 34834302
Sebaceous adenoma 13.01 10.79 5 122455 35 34834436
Inflammation 12.99 10.79 154 122306 28141 34806330
Disseminated varicella zoster virus infection 12.98 10.79 10 122450 311 34834160
Illness 12.97 10.79 17 122443 13512 34820959
Thymoma 12.96 10.79 6 122454 70 34834401
Herpes zoster cutaneous disseminated 12.96 10.79 8 122452 172 34834299
Superficial spreading melanoma stage unspecified 12.92 10.79 8 122452 173 34834298
Renal cell carcinoma stage III 12.89 10.79 4 122456 13 34834458
Splenic artery aneurysm 12.89 10.79 4 122456 13 34834458
Biliary catheter insertion 12.88 10.79 6 122454 71 34834400
Stenotrophomonas infection 12.86 10.79 25 122435 2085 34832386
Melaena 12.85 10.79 72 122388 35308 34799163
Anogenital warts 12.84 10.79 13 122447 584 34833887
Enamel anomaly 12.84 10.79 7 122453 118 34834353
Tooth hypoplasia 12.79 10.79 7 122453 119 34834352
Eccrine squamous syringometaplasia 12.78 10.79 5 122455 37 34834434
Throat irritation 12.72 10.79 11 122449 10574 34823897
Trichodysplasia spinulosa 12.68 10.79 9 122451 246 34834225
Needle issue 12.68 10.79 3 122457 6162 34828309
Atrial septal defect 12.67 10.79 5 122455 7387 34827084
Psoriasis area severity index increased 12.66 10.79 5 122455 38 34834433
Central nervous system vasculitis 12.66 10.79 12 122448 497 34833974
Hypomagnesaemia 12.66 10.79 37 122423 21814 34812657
Coombs direct test positive 12.65 10.79 10 122450 323 34834148
Surgery 12.64 10.79 89 122371 14068 34820403
Withdrawal syndrome 12.62 10.79 15 122445 12440 34822031
Acute generalised exanthematous pustulosis 12.62 10.79 4 122456 6772 34827699
Tracheitis 12.61 10.79 14 122446 700 34833771
Bronchopneumopathy 12.60 10.79 12 122448 500 34833971
Feeling hot 12.58 10.79 31 122429 19341 34815130
Colectomy 12.58 10.79 23 122437 1831 34832640
Liver abscess 12.57 10.79 36 122424 3859 34830612
Papillary cystadenoma lymphomatosum 12.55 10.79 5 122455 39 34834432
Keratitis bacterial 12.52 10.79 6 122454 76 34834395
Mental status changes 12.51 10.79 80 122380 38003 34796468
Clonal evolution 12.48 10.79 7 122453 125 34834346
Anti-platelet antibody positive 12.47 10.79 9 122451 253 34834218
Urinary bladder haematoma 12.45 10.79 4 122456 15 34834456
Oral papilloma 12.45 10.79 4 122456 15 34834456
Metastases to nasal sinuses 12.45 10.79 4 122456 15 34834456
Metastases to salivary gland 12.45 10.79 4 122456 15 34834456
Prescribed underdose 12.38 10.79 8 122452 8925 34825546
Incorrect dose administered 12.36 10.79 87 122373 40428 34794043
Accidental exposure to product 12.36 10.79 16 122444 12786 34821685
Skin hypertrophy 12.35 10.79 28 122432 2601 34831870
Nodule 12.34 10.79 52 122408 6767 34827704
Complement factor C3 decreased 12.34 10.79 5 122455 41 34834430
Sebaceous carcinoma 12.32 10.79 6 122454 79 34834392
H1N1 influenza 12.29 10.79 16 122444 946 34833525
Hypophagia 12.29 10.79 43 122417 23979 34810492
Gastrointestinal haemorrhage 12.28 10.79 227 122233 88250 34746221
Granulomatous dermatitis 12.25 10.79 9 122451 260 34834211
Tuberculosis 12.25 10.79 61 122399 8516 34825955
Ophthalmic vein thrombosis 12.23 10.79 5 122455 42 34834429
Amyloidosis senile 12.23 10.79 5 122455 42 34834429
Lung neoplasm 12.22 10.79 40 122420 4611 34829860
Neurological decompensation 12.20 10.79 30 122430 2936 34831535
Lesion excision 12.13 10.79 5 122455 43 34834428
Vitamin D deficiency 12.13 10.79 4 122456 6604 34827867
Endocarditis bacterial 12.12 10.79 16 122444 959 34833512
Renal aneurysm 12.10 10.79 7 122453 133 34834338
Hepatorenal syndrome 12.08 10.79 28 122432 2638 34831833
Semen volume decreased 12.07 10.79 10 122450 346 34834125
Hepatitis B surface antigen positive 12.05 10.79 7 122453 134 34834337
Chronic myeloid leukaemia recurrent 12.04 10.79 8 122452 196 34834275
Gastroenteritis salmonella 12.01 10.79 12 122448 531 34833940
Gastric haemorrhage 11.92 10.79 11 122449 10250 34824221
Nervousness 11.92 10.79 16 122444 12590 34821881
Enterobacter bacteraemia 11.91 10.79 11 122449 441 34834030
Hepatobiliary cancer 11.90 10.79 3 122457 3 34834468
Macrophage activation 11.90 10.79 3 122457 3 34834468
Transfusion associated graft versus host disease 11.90 10.79 3 122457 3 34834468
Leiomyoma 11.90 10.79 3 122457 3 34834468
Renal arteritis 11.90 10.79 3 122457 3 34834468
Vascular graft infection 11.90 10.79 3 122457 3 34834468
Cytomegalovirus enterocolitis 11.88 10.79 16 122444 978 34833493
Visual acuity reduced 11.88 10.79 97 122363 16052 34818419
Cholangitis chronic 11.87 10.79 4 122456 18 34834453
Biopsy liver 11.84 10.79 9 122451 274 34834197
Angina unstable 11.84 10.79 14 122446 11639 34822832
Cytomegalovirus test 11.84 10.79 5 122455 46 34834425
Aeromonas infection 11.82 10.79 9 122451 275 34834196
Campylobacter gastroenteritis 11.80 10.79 15 122445 866 34833605
Retroperitoneal neoplasm 11.70 10.79 4 122456 19 34834452
Iris neoplasm 11.70 10.79 4 122456 19 34834452
Viral myositis 11.70 10.79 4 122456 19 34834452
Serratia infection 11.66 10.79 15 122445 877 34833594
Bacteroides infection 11.65 10.79 7 122453 143 34834328
Medication error 11.63 10.79 48 122412 25517 34808954
Therapeutic procedure 11.62 10.79 8 122452 208 34834263
Lymphangitis 11.61 10.79 12 122448 553 34833918
Computerised tomogram abnormal 11.59 10.79 22 122438 1802 34832669
Intervertebral disc degeneration 11.58 10.79 4 122456 6413 34828058
Bile duct stent insertion 11.57 10.79 6 122454 91 34834380
Karyotype analysis abnormal 11.56 10.79 5 122455 49 34834422
Neutropenic sepsis 11.53 10.79 19 122441 13748 34820723
Laryngopharyngitis 11.53 10.79 4 122456 20 34834451
Sinusitis bacterial 11.50 10.79 11 122449 461 34834010
Acute myeloid leukaemia 11.49 10.79 106 122354 18164 34816307
Bronchoalveolar lavage 11.47 10.79 5 122455 50 34834421
Meningitis viral 11.46 10.79 15 122445 892 34833579
Pneumonia herpes viral 11.45 10.79 6 122454 93 34834378
Peripheral nerve palsy 11.45 10.79 3 122457 4 34834467
Pseudallescheria infection 11.45 10.79 3 122457 4 34834467
Ejection fraction decreased 11.41 10.79 32 122428 19122 34815349
Hypospermia 11.37 10.79 4 122456 21 34834450
Central venous pressure increased 11.37 10.79 4 122456 21 34834450
Blood glucose decreased 11.34 10.79 18 122442 13219 34821252
Coronary artery occlusion 11.32 10.79 13 122447 10949 34823522
Nasal congestion 11.31 10.79 42 122418 23015 34811456
Eye discharge 11.30 10.79 23 122437 1983 34832488
Low turnover osteopathy 11.28 10.79 6 122454 96 34834375
Pneumonia respiratory syncytial viral 11.25 10.79 15 122445 908 34833563
Pericardial drainage 11.23 10.79 6 122454 97 34834374
Bronchioloalveolar carcinoma 11.22 10.79 4 122456 22 34834449
Cerebrosclerosis 11.22 10.79 4 122456 22 34834449
Ureteral necrosis 11.22 10.79 5 122455 53 34834418
Herpes ophthalmic 11.21 10.79 12 122448 576 34833895
Corneal scar 11.19 10.79 7 122453 154 34834317
Faeces discoloured 11.15 10.79 22 122438 14856 34819615
Rotator cuff syndrome 11.13 10.79 3 122457 5646 34828825
Wound 11.12 10.79 22 122438 14842 34819629
Activated partial thromboplastin time shortened 11.09 10.79 11 122449 482 34833989
Sjogren's syndrome 11.06 10.79 5 122455 55 34834416
Chest wall abscess 11.04 10.79 7 122453 158 34834313
Blood urine present 11.03 10.79 13 122447 10821 34823650
Atelectasis 11.02 10.79 29 122431 17698 34816773
Aspiration 11.01 10.79 16 122444 12178 34822293
Renal necrosis 11.00 10.79 7 122453 159 34834312
Bone marrow transplant 10.99 10.79 16 122444 1052 34833419
Enterococcal bacteraemia 10.98 10.79 22 122438 1875 34832596
T-cell prolymphocytic leukaemia 10.98 10.79 5 122455 56 34834415
Heparin-induced thrombocytopenia 10.97 10.79 3 122457 5592 34828879
Dermatitis acneiform 10.92 10.79 4 122456 6185 34828286
Eye abscess 10.92 10.79 7 122453 161 34834310
Scopulariopsis infection 10.91 10.79 6 122454 103 34834368
Injection site reaction 10.91 10.79 18 122442 13015 34821456
Multiple use of single-use product 10.89 10.79 9 122451 310 34834161
Hepatomegaly 10.88 10.79 68 122392 10328 34824143
Aneurysm 10.86 10.79 22 122438 1890 34832581
VIth nerve paralysis 10.86 10.79 14 122446 820 34833651
Hypereosinophilic syndrome 10.83 10.79 8 122452 233 34834238
Botulism 10.81 10.79 7 122453 164 34834307
Body height below normal 10.81 10.79 8 122452 234 34834237
Chronic granulomatous disease 10.79 10.79 4 122456 25 34834446
Lung assist device therapy 10.79 10.79 4 122456 25 34834446

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 3300.47 9.78 1868 233854 40776 79467890
Graft versus host disease 2179.23 9.78 1006 234716 14020 79494646
Acute graft versus host disease 1992.34 9.78 841 234881 9326 79499340
Product use in unapproved indication 1816.17 9.78 2904 232818 247455 79261211
Acute graft versus host disease in skin 1681.14 9.78 687 235035 6971 79501695
Chronic graft versus host disease 1646.19 9.78 654 235068 6127 79502539
Transplant rejection 1635.21 9.78 900 234822 18537 79490129
Transplant dysfunction 1480.72 9.78 617 235105 6604 79502062
Epstein-Barr virus infection 1401.70 9.78 735 234987 13681 79494985
Post transplant lymphoproliferative disorder 1391.13 9.78 679 235043 10785 79497881
Graft versus host disease in gastrointestinal tract 1163.26 9.78 501 235221 5855 79502811
Graft versus host disease in skin 1005.18 9.78 446 235276 5627 79503039
Posterior reversible encephalopathy syndrome 986.31 9.78 731 234991 25550 79483116
Kidney transplant rejection 910.32 9.78 492 235230 9754 79498912
Acute graft versus host disease in intestine 810.71 9.78 340 235382 3701 79504965
BK virus infection 802.41 9.78 430 235292 8374 79500292
Eye irritation 797.98 9.78 585 235137 20096 79488570
Cystitis haemorrhagic 755.61 9.78 419 235303 8753 79499913
Thrombotic microangiopathy 703.44 9.78 537 235185 19632 79489034
Ovarian cyst 697.15 9.78 446 235276 12209 79496457
Adenovirus infection 693.45 9.78 385 235337 8062 79500604
Completed suicide 679.06 9.78 9 235713 245758 79262908
Cytomegalovirus infection reactivation 644.55 9.78 371 235351 8345 79500321
Nephropathy toxic 603.16 9.78 493 235229 19926 79488740
Renal impairment 573.26 9.78 1369 234353 156414 79352252
Cytomegalovirus viraemia 555.01 9.78 389 235333 12432 79496234
Drug ineffective 551.31 9.78 5230 230492 1075683 78432983
Aspergillus infection 535.47 9.78 448 235274 18713 79489953
Epstein-Barr virus associated lymphoproliferative disorder 497.99 9.78 232 235490 3300 79505366
Blood creatinine increased 497.43 9.78 1283 234439 153774 79354892
Multiple organ dysfunction syndrome 484.64 9.78 1087 234635 119159 79389507
Bronchopulmonary aspergillosis 484.56 9.78 452 235270 21842 79486824
Acute graft versus host disease in liver 470.89 9.78 187 235535 1748 79506918
Fatigue 460.19 9.78 1326 234396 928401 78580265
Acne 454.95 9.78 478 235244 26712 79481954
Fall 445.60 9.78 471 235251 487158 79021508
Haemophagocytic lymphohistiocytosis 438.92 9.78 424 235298 21413 79487253
Dizziness 429.01 9.78 557 235165 525884 78982782
Drug abuse 421.44 9.78 13 235709 162678 79345988
Chronic graft versus host disease in skin 421.38 9.78 163 235559 1411 79507255
Immunosuppressant drug level increased 370.16 9.78 265 235457 8762 79499904
Complications of transplanted kidney 369.68 9.78 232 235490 6134 79502532
Gingival hypertrophy 348.16 9.78 175 235547 2967 79505699
Pneumonia cytomegaloviral 339.63 9.78 201 235521 4768 79503898
Drug eruption 337.16 9.78 524 235198 43411 79465255
Hypotension 332.32 9.78 492 235230 439825 79068841
Dyspnoea 327.79 9.78 1364 234358 855661 78653005
Liver transplant rejection 319.63 9.78 167 235555 3081 79505585
Graft versus host disease in liver 316.80 9.78 137 235585 1617 79507049
Blood parathyroid hormone decreased 293.65 9.78 246 235476 10290 79498376
Panniculitis 292.57 9.78 263 235459 12108 79496558
Basal cell carcinoma 288.51 9.78 447 235275 36928 79471738
Cytomegalovirus test positive 282.29 9.78 191 235531 5756 79502910
Human herpesvirus 6 infection 277.89 9.78 182 235540 5188 79503478
Intentional overdose 276.07 9.78 8 235714 105952 79402714
Venoocclusive liver disease 268.08 9.78 245 235477 11526 79497140
Obliterative bronchiolitis 265.03 9.78 144 235578 2884 79505782
Granuloma skin 263.57 9.78 218 235504 8956 79499710
Hepatic function abnormal 261.62 9.78 631 235091 72476 79436190
Skin necrosis 257.32 9.78 292 235430 17795 79490871
Heart transplant rejection 256.64 9.78 113 235609 1397 79507269
Nausea 255.44 9.78 1721 234001 955475 78553191
Transplant failure 249.25 9.78 161 235561 4480 79504186
Asthenia 249.12 9.78 734 234988 510955 78997711
Chronic graft versus host disease in liver 248.25 9.78 88 235634 579 79508087
Chronic allograft nephropathy 243.12 9.78 113 235609 1598 79507068
Constipation 241.11 9.78 289 235433 282761 79225905
Treatment failure 241.03 9.78 1071 234651 169415 79339251
Polyomavirus viraemia 240.26 9.78 112 235610 1595 79507071
Glossodynia 239.53 9.78 17 235705 103320 79405346
Venoocclusive disease 239.12 9.78 156 235566 4417 79504249
Mucormycosis 238.64 9.78 199 235523 8270 79500396
Foreign body sensation in eyes 238.60 9.78 120 235602 2037 79506629
Syncope 236.96 9.78 117 235605 179332 79329334
Death 235.62 9.78 871 234851 565643 78943023
Pemphigus 234.88 9.78 15 235707 99567 79409099
Pseudomonas infection 226.50 9.78 294 235428 20609 79488057
Lymphoproliferative disorder 226.01 9.78 163 235559 5452 79503214
Polyomavirus-associated nephropathy 223.42 9.78 162 235560 5465 79503201
Epstein-Barr virus infection reactivation 223.31 9.78 110 235612 1782 79506884
Squamous cell carcinoma 216.82 9.78 249 235473 15373 79493293
Somnolence 216.57 9.78 232 235490 238749 79269917
Anxiety 215.63 9.78 250 235472 248262 79260404
Psoriasis 209.70 9.78 662 235060 88925 79419741
Vomiting 207.11 9.78 1140 234582 664688 78843978
Proteinuria 206.51 9.78 356 235366 32146 79476520
Immunosuppressant drug level decreased 205.70 9.78 106 235616 1898 79506768
Pneumocystis jirovecii pneumonia 205.15 9.78 355 235367 32153 79476513
Mucosal inflammation 202.77 9.78 586 235136 74994 79433672
Lung transplant rejection 198.74 9.78 95 235627 1436 79507230
Complications of bone marrow transplant 198.55 9.78 74 235648 572 79508094
Drug resistance 197.95 9.78 406 235316 41807 79466859
Pain 196.14 9.78 1248 234474 702554 78806112
Enthesopathy 195.81 9.78 205 235517 11403 79497263
Dehydration 191.21 9.78 273 235449 247914 79260752
Disease recurrence 183.44 9.78 404 235318 43705 79464961
Confusional state 181.40 9.78 421 235301 317576 79191090
Therapeutic response decreased 179.97 9.78 519 235203 66334 79442332
Smooth muscle cell neoplasm 179.86 9.78 77 235645 885 79507781
Rheumatoid nodule 177.71 9.78 238 235484 17200 79491466
Bradycardia 176.50 9.78 90 235632 135467 79373199
Wound 175.46 9.78 62 235660 116117 79392549
Eye pain 174.52 9.78 360 235362 37218 79471448
Hand deformity 173.98 9.78 46 235676 103873 79404793
Renal transplant failure 173.36 9.78 93 235629 1814 79506852
Swelling 170.28 9.78 235 235487 216476 79292190
Hyperhidrosis 170.01 9.78 120 235602 151372 79357294
Viraemia 167.70 9.78 105 235617 2764 79505902
Off label use 167.46 9.78 3677 232045 903538 78605128
Chronic graft versus host disease in intestine 166.25 9.78 56 235666 309 79508357
Ulcer 165.72 9.78 309 235413 29663 79479003
Diffuse large B-cell lymphoma 164.16 9.78 191 235531 11958 79496708
Epstein-Barr viraemia 163.40 9.78 94 235628 2111 79506555
Pericarditis 161.97 9.78 53 235669 104183 79404483
Cytomegalovirus colitis 159.51 9.78 123 235599 4562 79504104
Duodenal ulcer perforation 159.08 9.78 9 235713 66202 79442464
Systemic lupus erythematosus 158.37 9.78 80 235642 121069 79387597
Tenosynovitis 156.54 9.78 211 235511 15343 79493323
Therapy non-responder 156.28 9.78 613 235109 91692 79416974
Instillation site pain 155.71 9.78 64 235658 659 79508007
Oral administration complication 155.59 9.78 43 235679 102 79508564
Hyponatraemia 155.20 9.78 178 235544 177670 79330996
Product dose omission issue 155.00 9.78 311 235411 247226 79261440
Malaise 153.04 9.78 837 234885 489032 79019634
SLE arthritis 150.22 9.78 59 235663 534 79508132
Electrocardiogram QT prolonged 149.44 9.78 41 235681 90345 79418321
Kaposi's sarcoma 149.36 9.78 63 235659 696 79507970
Alanine aminotransferase abnormal 148.50 9.78 156 235566 8711 79499955
Decreased appetite 148.37 9.78 517 235205 341901 79166765
Weight increased 148.11 9.78 380 235342 277006 79231660
Viral haemorrhagic cystitis 147.78 9.78 86 235636 1975 79506691
Hypogammaglobulinaemia 146.35 9.78 186 235536 12765 79495901
Cerebrovascular accident 146 9.78 146 235576 155146 79353520
Helicobacter infection 144.24 9.78 18 235704 69686 79438980
Ocular hyperaemia 143.87 9.78 281 235441 27925 79480741
Alveolar proteinosis 143.72 9.78 62 235660 727 79507939
Abdominal discomfort 143.69 9.78 331 235391 250396 79258270
JC virus infection 143.41 9.78 107 235615 3774 79504892
Cytomegalovirus chorioretinitis 142.38 9.78 123 235599 5367 79503299
Hypoglycaemia 142.20 9.78 61 235661 101533 79407133
Hypokalaemia 141.73 9.78 130 235592 143910 79364756
Herpes simplex 140.84 9.78 177 235545 12010 79496656
Cutaneous T-cell lymphoma 140.82 9.78 92 235630 2611 79506055
Nocardiosis 140.77 9.78 124 235598 5555 79503111
Cardiac failure congestive 140.74 9.78 128 235594 142274 79366392
Suicide attempt 140.18 9.78 36 235686 82896 79425770
Skin plaque 138.67 9.78 165 235557 10580 79498086
Kidney fibrosis 138.59 9.78 101 235621 3434 79505232
Back pain 137.39 9.78 451 235271 303729 79204937
Focal segmental glomerulosclerosis 137.32 9.78 98 235624 3223 79505443
Palpitations 135.96 9.78 105 235617 126505 79382161
Acute myeloid leukaemia recurrent 135.69 9.78 98 235624 3285 79505381
Wheezing 135.45 9.78 89 235633 116575 79392091
Cardio-respiratory arrest 135.44 9.78 76 235646 108434 79400232
Toxicity to various agents 135.07 9.78 714 235008 420826 79087840
Skin ulcer 134.89 9.78 409 235313 53741 79454925
Chorioretinopathy 133.81 9.78 83 235639 2148 79506518
Red blood cell sedimentation rate increased 133.77 9.78 367 235355 45575 79463091
Drug ineffective for unapproved indication 133.31 9.78 393 235329 50845 79457821
Gastrooesophageal reflux disease 133.05 9.78 71 235651 104175 79404491
Abdominal pain upper 131.88 9.78 291 235431 223528 79285138
Leukaemia recurrent 131.44 9.78 89 235633 2685 79505981
Lymphocele 130.84 9.78 74 235648 1607 79507059
Tongue disorder 129.24 9.78 182 235540 13793 79494873
Neurotoxicity 128.66 9.78 292 235430 32226 79476440
Pneumomediastinum 128.63 9.78 98 235624 3569 79505097
Depression 128.44 9.78 281 235441 216509 79292157
Bacterial infection 128.36 9.78 285 235437 30995 79477671
Hypercalcaemia 127.18 9.78 322 235400 38108 79470558
Staphylococcal infection 123.08 9.78 416 235306 57879 79450787
Graft versus host disease in lung 122.69 9.78 58 235664 854 79507812
Blood bilirubin increased 121.27 9.78 451 235271 65781 79442885
Pyrexia 121.12 9.78 2739 232983 675970 78832696
Aplastic anaemia 120.19 9.78 201 235521 17704 79490962
Engraft failure 120.02 9.78 53 235669 660 79508006
Nasopharyngitis 119.82 9.78 369 235353 253512 79255154
Scleral hyperaemia 119.04 9.78 42 235680 272 79508394
Asthma 118.07 9.78 135 235587 134960 79373706
Aplasia pure red cell 117.79 9.78 130 235592 7680 79500986
Chronic obstructive pulmonary disease 116.84 9.78 53 235669 85366 79423300
Chest pain 115.78 9.78 436 235286 281868 79226798
Diabetes mellitus 115.65 9.78 499 235223 77891 79430775
Muscle injury 115.44 9.78 7 235715 48554 79460112
C-reactive protein increased 114.71 9.78 713 235009 128314 79380352
Balance disorder 113.96 9.78 76 235646 98781 79409885
Enterococcal infection 113.50 9.78 182 235540 15478 79493188
Irritable bowel syndrome 113.21 9.78 23 235699 62218 79446448
Hepatitis C 112.81 9.78 157 235565 11768 79496898
Lactic acidosis 110.67 9.78 35 235687 70324 79438342
Cystitis viral 109.44 9.78 50 235672 678 79507988
Diarrhoea 109.36 9.78 1889 233833 878600 78630066
Demyelination 108.18 9.78 126 235596 7897 79500769
Intentional product misuse 107.25 9.78 75 235647 95090 79413576
Malignant neoplasm progression 107.24 9.78 147 235575 135843 79372823
Ototoxicity 107.21 9.78 84 235638 3190 79505476
Sepsis 107.17 9.78 1243 234479 268185 79240481
Haemolysis 107.02 9.78 159 235563 12653 79496013
End stage renal disease 106.91 9.78 155 235567 12065 79496601
International normalised ratio increased 106.22 9.78 59 235663 84662 79424004
Skin lesion 106.05 9.78 318 235404 41526 79467140
Overdose 105.64 9.78 243 235479 183963 79324703
Anti-cyclic citrullinated peptide antibody positive 105.55 9.78 57 235665 83086 79425580
Disseminated tuberculosis 105.02 9.78 92 235630 4091 79504575
Atrial fibrillation 104.88 9.78 272 235450 197614 79311052
Contusion 104.59 9.78 174 235548 148602 79360064
Cryptococcosis 104.52 9.78 85 235637 3408 79505258
Bacterial sepsis 104.33 9.78 125 235597 8073 79500593
Epstein-Barr virus associated lymphoma 104.33 9.78 55 235667 1034 79507632
Renal tubular atrophy 103.66 9.78 66 235656 1790 79506876
Cardiac arrest 102.80 9.78 222 235500 171874 79336792
Septic shock 102.60 9.78 668 235054 122133 79386533
Coombs positive haemolytic anaemia 102.42 9.78 55 235667 1075 79507591
Stem cell transplant 102.22 9.78 86 235636 3618 79505048
Discomfort 101.89 9.78 133 235589 125484 79383182
Hypoaesthesia 101.73 9.78 238 235484 179114 79329552
Pathogen resistance 101.65 9.78 165 235557 14177 79494489
Fungal infection 100.87 9.78 312 235410 41436 79467230
Red blood cell sedimentation rate 100.58 9.78 102 235620 5463 79503203
Pseudomonal sepsis 100.51 9.78 107 235615 6067 79502599
Pancytopenia 100.37 9.78 835 234887 164910 79343756
Haemolytic uraemic syndrome 100.13 9.78 92 235630 4357 79504309
Elbow deformity 99.03 9.78 60 235662 1487 79507179
Injection site pain 98.76 9.78 144 235578 129694 79378972
Inflammation 98.17 9.78 541 235181 93212 79415454
Pneumonia fungal 97.80 9.78 142 235580 11068 79497598
Psoriatic arthropathy 96.14 9.78 471 235251 77528 79431138
Alanine aminotransferase increased 95.26 9.78 813 234909 161757 79346909
Flushing 95.01 9.78 73 235649 88195 79420471
Lower respiratory tract infection 94.72 9.78 147 235575 129073 79379593
Agitation 93.41 9.78 94 235628 99621 79409045
Graft versus host disease in eye 92.44 9.78 35 235687 284 79508382
Paraesthesia 92.18 9.78 244 235478 176079 79332587
Hirsutism 92.09 9.78 55 235667 1327 79507339
Glomerulosclerosis 91.70 9.78 51 235671 1071 79507595
Scedosporium infection 91.22 9.78 56 235666 1422 79507244
General physical health deterioration 90.41 9.78 462 235260 274776 79233890
Hospitalisation 90.39 9.78 87 235635 94149 79414517
Suicidal ideation 90.29 9.78 57 235665 76283 79432383
Blood lactate dehydrogenase increased 90.28 9.78 288 235434 38882 79469784
Blood iron abnormal 90.04 9.78 54 235668 1313 79507353
Systemic mycosis 88.60 9.78 69 235653 2597 79506069
Eye discharge 88.53 9.78 99 235623 5935 79502731
Hypertrichosis 87.98 9.78 52 235670 1230 79507436
Autoimmune haemolytic anaemia 87.88 9.78 116 235606 8264 79500402
Liver function test abnormal 87.22 9.78 400 235322 64075 79444591
Sedation 86.79 9.78 23 235699 51872 79456794
Haemodialysis 86.65 9.78 176 235546 17992 79490674
Myocardial infarction 86.57 9.78 268 235454 183861 79324805
Bacteraemia 86.55 9.78 253 235469 32571 79476095
Orthostatic hypotension 86.46 9.78 29 235693 56135 79452531
Toxoplasmosis 85.74 9.78 68 235654 2629 79506037
Renal failure 85.22 9.78 939 234783 200029 79308637
Varicella zoster virus infection 85.05 9.78 84 235638 4357 79504309
Injury 84.81 9.78 63 235659 77433 79431233
Cerebral toxoplasmosis 84.78 9.78 64 235658 2298 79506368
Blood stem cell transplant failure 84.40 9.78 38 235684 497 79508169
Arthralgia 84.24 9.78 1187 234535 570616 78938050
Nephrotic syndrome 83.92 9.78 132 235590 11042 79497624
Pneumatosis intestinalis 83.81 9.78 99 235623 6298 79502368
Engraftment syndrome 83.45 9.78 52 235670 1357 79507309
Aspartate aminotransferase increased 81.56 9.78 694 235028 137947 79370719
Graft loss 81.41 9.78 46 235676 997 79507669
Injection site erythema 81.24 9.78 67 235655 78130 79430536
Oxygen saturation decreased 80.82 9.78 162 235560 128885 79379781
Sopor 80.82 9.78 4 235718 33006 79475660
Loss of consciousness 80.69 9.78 242 235480 167701 79340965
Osteonecrosis of jaw 80.67 9.78 15 235707 43211 79465455
Klebsiella infection 80.64 9.78 157 235565 15563 79493103
Pulmonary embolism 80.58 9.78 250 235472 171404 79337262
Complications of transplanted heart 80.53 9.78 33 235689 337 79508329
Squamous cell carcinoma of skin 80.49 9.78 147 235575 13886 79494780
Prescribed overdose 80.31 9.78 9 235713 37874 79470792
Progressive multifocal leukoencephalopathy 79.29 9.78 183 235539 20417 79488249
Memory impairment 79.15 9.78 130 235592 111604 79397062
Serum sickness 79.01 9.78 74 235648 3592 79505074
Human polyomavirus infection 78.90 9.78 46 235676 1060 79507606
Actinic keratosis 78.33 9.78 93 235629 5949 79502717
Tendonitis 78.14 9.78 199 235523 23631 79485035
Red blood cell schistocytes present 77.83 9.78 37 235685 552 79508114
Encephalitis viral 77.68 9.78 63 235659 2516 79506150
Mycobacterial infection 77.06 9.78 73 235649 3595 79505071
Viral test positive 76.79 9.78 33 235689 383 79508283
Rectal haemorrhage 76.06 9.78 68 235654 76232 79432434
Skin mass 76.04 9.78 106 235616 7957 79500709
Leukopenia 75.95 9.78 597 235125 115916 79392750
Drug reaction with eosinophilia and systemic symptoms 75.93 9.78 48 235674 64196 79444470
Delirium 75.65 9.78 83 235639 84544 79424122
Acute lymphocytic leukaemia recurrent 75.37 9.78 81 235641 4643 79504023
Pulmonary tuberculosis 75.07 9.78 104 235618 7761 79500905
Folliculitis 74.74 9.78 35 235687 55345 79453321
Encephalitis cytomegalovirus 74.64 9.78 45 235677 1105 79507561
Herpes virus infection 74.58 9.78 98 235624 6951 79501715
Herpes zoster 73.90 9.78 500 235222 92583 79416083
Fusarium infection 73.32 9.78 53 235669 1779 79506887
Impaired gastric emptying 73.22 9.78 119 235603 10234 79498432
Cough 73.09 9.78 712 235010 366077 79142589
Hair follicle tumour benign 72.93 9.78 33 235689 437 79508229
Renal tubular necrosis 72.86 9.78 200 235522 24839 79483827
Chest discomfort 72.16 9.78 191 235531 137853 79370813
Lung infiltration 70.68 9.78 187 235535 22725 79485941
Bone marrow failure 70.57 9.78 319 235403 50788 79457878
Multiple sclerosis relapse 69.95 9.78 25 235697 46508 79462158
Lymphadenopathy 69.56 9.78 327 235395 52920 79455746
Headache 69.42 9.78 1440 234282 652332 78856334
Rash 69.29 9.78 1248 234474 577110 78931556
Blood glucose increased 68.90 9.78 148 235574 114827 79393839
Acute respiratory distress syndrome 68.45 9.78 285 235437 43782 79464884
Insomnia 68.37 9.78 434 235288 244736 79263930
American trypanosomiasis 68.23 9.78 29 235693 327 79508339
Rheumatic fever 68.14 9.78 4 235718 28521 79480145
Mycoplasma infection 67.61 9.78 37 235685 752 79507914
Glomerulonephritis membranous 67.54 9.78 48 235674 1568 79507098
Acute myocardial infarction 67.27 9.78 77 235645 76959 79431707
Drug tolerance decreased 67.04 9.78 130 235592 12848 79495818
Toxic leukoencephalopathy 66.86 9.78 42 235680 1112 79507554
Oedema peripheral 66.62 9.78 454 235268 251834 79256832
Graft complication 66.61 9.78 36 235686 713 79507953
Thrombotic thrombocytopenic purpura 66.46 9.78 88 235634 6288 79502378
Bacillary angiomatosis 66.42 9.78 26 235696 233 79508433
Opportunistic infection 66.39 9.78 61 235661 2889 79505777
Serotonin syndrome 66.32 9.78 25 235697 45002 79463664
Rheumatoid factor positive 66.31 9.78 48 235674 59791 79448875
Plasmablastic lymphoma 66.28 9.78 32 235690 495 79508171
Complications of transplant surgery 66.25 9.78 36 235686 721 79507945
Drug level increased 66.01 9.78 262 235460 39389 79469277
Product container issue 64.96 9.78 43 235679 1248 79507418
Escherichia infection 64.94 9.78 156 235566 17861 79490805
Lymphocytic infiltration 64.61 9.78 46 235676 1507 79507159
Enterococcal sepsis 64.54 9.78 58 235664 2668 79505998
Disseminated cryptococcosis 64.30 9.78 49 235673 1785 79506881
Pyogenic granuloma 63.95 9.78 31 235691 484 79508182
Erythrodermic psoriasis 63.91 9.78 48 235674 1710 79506956
Granuloma 63.68 9.78 99 235623 8198 79500468
C-reactive protein abnormal 63.16 9.78 297 235425 48070 79460596
Systemic candida 63.00 9.78 88 235634 6618 79502048
Lacrimation increased 62.90 9.78 177 235545 22300 79486366
Tachycardia 62.62 9.78 291 235431 177477 79331189
Respiratory failure 62.50 9.78 813 234909 180098 79328568
Brain abscess 62.38 9.78 75 235647 4861 79503805
Knee arthroplasty 62.07 9.78 25 235697 43223 79465443
B-cell lymphoma 62.06 9.78 84 235638 6131 79502535
Urinary retention 62.01 9.78 46 235676 56584 79452082
Superficial injury of eye 61.58 9.78 23 235699 179 79508487
Serum ferritin increased 61.42 9.78 107 235615 9740 79498926
Transient ischaemic attack 61.42 9.78 40 235682 52655 79456011
Fear of injection 61.34 9.78 92 235630 7382 79501284
Arthropathy 60.58 9.78 293 235429 176818 79331848
Glomerulonephritis 60.37 9.78 62 235660 3371 79505295
Heart rate increased 60.13 9.78 171 235551 120553 79388113
Leukoencephalopathy 60.01 9.78 94 235628 7835 79500831
Encephalitis 60.01 9.78 134 235588 14626 79494040
Rhabdomyolysis 59.98 9.78 515 235207 102616 79406050
Human herpesvirus 8 infection 59.86 9.78 40 235682 1180 79507486
Bronchiolitis obliterans syndrome 59.66 9.78 26 235696 313 79508353
Erythema of eyelid 59.51 9.78 54 235668 2516 79506150
Microangiopathy 59.24 9.78 47 235675 1818 79506848
Hyperplasia 59.18 9.78 40 235682 1203 79507463
Poisoning 59.01 9.78 4 235718 25268 79483398
Deep vein thrombosis 58.97 9.78 173 235549 120746 79387920
Drug withdrawal syndrome 58.80 9.78 15 235707 34703 79473963
Haptoglobin decreased 58.59 9.78 41 235681 1306 79507360
Microangiopathic haemolytic anaemia 58.44 9.78 43 235679 1484 79507182
Feeling abnormal 58.22 9.78 257 235465 158942 79349724
Pneumonia adenoviral 58.15 9.78 29 235693 483 79508183
Microsporidia infection 58.09 9.78 36 235686 930 79507736
Dyspepsia 57.85 9.78 149 235573 108538 79400128
Unresponsive to stimuli 57.70 9.78 48 235674 55740 79452926
Steroid diabetes 57.50 9.78 61 235661 3445 79505221
Sleep disorder 56.74 9.78 104 235618 85573 79423093
Meningoencephalitis herpetic 56.58 9.78 47 235675 1942 79506724
Nephrectomy 56.10 9.78 48 235674 2067 79506599
Drug intolerance 56.02 9.78 1094 234628 263025 79245641
Hypertension 55.46 9.78 1325 234397 329667 79178999
Swollen joint count increased 55.43 9.78 3 235719 22924 79485742
Respiratory arrest 55.34 9.78 53 235669 57497 79451169
Device expulsion 55.19 9.78 6 235716 25855 79482811
Bursitis 54.32 9.78 19 235703 35825 79472841
Complications of transplanted lung 54.28 9.78 27 235695 447 79508219
Vertigo 54.12 9.78 75 235647 69007 79439659
Presyncope 53.80 9.78 27 235695 41027 79467639
Abdominal pain 53.69 9.78 819 234903 388750 79119916
Clear cell renal cell carcinoma 53.61 9.78 51 235671 2525 79506141
Blood pressure fluctuation 53.50 9.78 72 235650 67073 79441593
Gait disturbance 53.49 9.78 376 235346 207130 79301536
Device dislocation 53.01 9.78 7 235715 25963 79482703
Joint swelling 52.66 9.78 572 235150 288074 79220592
Biopsy kidney abnormal 52.33 9.78 20 235702 167 79508499
Acinetobacter infection 52.21 9.78 52 235670 2725 79505941
Weight decreased 51.97 9.78 738 234984 354460 79154206
Blood potassium decreased 51.94 9.78 37 235685 46475 79462191
Aggression 51.29 9.78 45 235677 50913 79457753
Coma 51.28 9.78 141 235581 100508 79408158
Lymphadenitis 51.25 9.78 66 235656 4589 79504077
Idiopathic pneumonia syndrome 51.21 9.78 28 235694 568 79508098
Road traffic accident 51.08 9.78 33 235689 43631 79465035
Bone marrow transplant rejection 51.07 9.78 22 235700 257 79508409
Post transplant distal limb syndrome 51.03 9.78 28 235694 572 79508094
Sinusitis 51 9.78 353 235369 195148 79313518
Hepatosplenic T-cell lymphoma 50.98 9.78 32 235690 846 79507820
Hepatitis E 50.84 9.78 53 235669 2933 79505733
Osteonecrosis 50.58 9.78 204 235518 30891 79477775
Mechanical ventilation 50.57 9.78 51 235671 2713 79505953
Pulmonary haemorrhage 50.45 9.78 125 235597 14592 79494074
Infection reactivation 50.41 9.78 50 235672 2607 79506059
Coronary artery disease 50.38 9.78 72 235650 65402 79443264
Medication error 50.37 9.78 78 235644 68564 79440102
Pulmonary nocardiosis 50.36 9.78 37 235685 1274 79507392
Alternaria infection 50.34 9.78 29 235693 653 79508013
Renal transplant 50.31 9.78 49 235673 2498 79506168
Ventricular tachycardia 50.01 9.78 31 235691 41904 79466762
Myopathy 49.97 9.78 154 235568 20409 79488257
Eye pruritus 49.93 9.78 154 235568 20416 79488250
Impaired healing 49.93 9.78 116 235606 87539 79421127
Cognitive disorder 49.85 9.78 81 235641 69845 79438821
Scleroderma 49.83 9.78 71 235651 5439 79503227
Chimerism 49.82 9.78 22 235700 274 79508392
Cushingoid 49.73 9.78 96 235626 9456 79499210
Cytomegalovirus syndrome 49.46 9.78 22 235700 279 79508387
Transaminases increased 49.17 9.78 291 235431 51452 79457214
Hypocalcaemia 49.15 9.78 45 235677 49879 79458787
Life support 49.10 9.78 25 235697 436 79508230
Apoptosis 49.07 9.78 26 235696 494 79508172
Corneal endotheliitis 48.80 9.78 16 235706 80 79508586
Haemosiderosis 48.75 9.78 26 235696 501 79508165
Parvovirus B19 infection 48.52 9.78 38 235684 1442 79507224
Sebaceous hyperplasia 48.44 9.78 15 235707 60 79508606
Gastroenteritis rotavirus 48.27 9.78 24 235698 397 79508269
Candida infection 47.96 9.78 232 235490 37982 79470684
Type 2 diabetes mellitus 47.84 9.78 59 235663 57063 79451603
Intentional self-injury 47.74 9.78 18 235704 32401 79476265
Laparotomy 47.63 9.78 24 235698 409 79508257
Hallucination 47.62 9.78 115 235607 85630 79423036
Aplasia 47.51 9.78 84 235638 7736 79500930
Angiocentric lymphoma 47.50 9.78 31 235691 878 79507788
Dermatitis exfoliative generalised 46.89 9.78 80 235642 7161 79501505
Lymphoid tissue hypoplasia 46.86 9.78 31 235691 899 79507767
Blood urea increased 46.75 9.78 275 235447 48515 79460151
Trichophytic granuloma 46.67 9.78 14 235708 49 79508617
Lupus vasculitis 46.66 9.78 26 235696 548 79508118
Respiratory tract infection fungal 46.07 9.78 34 235688 1179 79507487
Neuropathy peripheral 45.89 9.78 238 235484 141067 79367599
Vein rupture 45.62 9.78 42 235680 1994 79506672
Mycobacterium kansasii infection 45.58 9.78 22 235700 340 79508326
Thymus hypoplasia 45.58 9.78 31 235691 942 79507724
Full blood count abnormal 45.46 9.78 32 235690 40442 79468224
Disseminated intravascular coagulation 45.27 9.78 218 235504 35624 79473042
Hepatic fibrosis 45.27 9.78 79 235643 7201 79501465
Heart rate irregular 45.11 9.78 20 235702 32659 79476007
Fungal endocarditis 45.03 9.78 26 235696 588 79508078
Chronic graft versus host disease in eye 45.00 9.78 17 235705 137 79508529
Renal lymphocele 44.91 9.78 16 235706 107 79508559
Influenza like illness 44.90 9.78 90 235632 71617 79437049
Drug dependence 44.79 9.78 33 235689 40736 79467930
Chronic graft versus host disease oral 44.68 9.78 17 235705 140 79508526
Adenoviral hepatitis 44.54 9.78 30 235692 897 79507769
Concomitant disease progression 44.27 9.78 53 235669 3420 79505246
Staphylococcal sepsis 44.22 9.78 119 235603 14607 79494059
Blister 44.21 9.78 192 235530 119284 79389382
Injection site pruritus 44.20 9.78 36 235686 42247 79466419
Reticulocyte count increased 44.18 9.78 35 235687 1351 79507315
Head injury 44.05 9.78 28 235694 37341 79471325
Unevaluable event 43.89 9.78 60 235662 55525 79453141
Cytokine release syndrome 43.78 9.78 26 235696 35972 79472694
Heart rate decreased 43.39 9.78 89 235633 70227 79438439
Pneumocystis jirovecii infection 43.35 9.78 48 235674 2846 79505820
Dyskinesia 43.32 9.78 41 235681 44732 79463934
Adenoviral haemorrhagic cystitis 43.28 9.78 24 235698 501 79508165
Legionella infection 43.25 9.78 28 235694 782 79507884
Enterobacter infection 43.06 9.78 60 235662 4502 79504164
Oral lichen planus 42.75 9.78 28 235694 798 79507868
Laryngitis fungal 42.24 9.78 16 235706 130 79508536
Pustular psoriasis 42.10 9.78 61 235661 4745 79503921
Abdominal distension 42.04 9.78 196 235526 119454 79389212
Glomerulonephropathy 42.03 9.78 20 235702 299 79508367
Anuria 41.97 9.78 147 235575 20816 79487850
Ureteric stenosis 41.92 9.78 34 235688 1358 79507308
Nephroureterectomy 41.88 9.78 10 235712 9 79508657
Gouty tophus 41.85 9.78 22 235700 411 79508255
Disseminated aspergillosis 41.70 9.78 31 235691 1087 79507579
Sinus tachycardia 41.69 9.78 29 235693 36879 79471787
Pallor 41.62 9.78 52 235670 50010 79458656
Neoplasm skin 41.59 9.78 36 235686 1575 79507091
Cytogenetic abnormality 41.53 9.78 31 235691 1094 79507572
Visual acuity reduced 41.47 9.78 185 235537 29284 79479382
Growth retardation 41.45 9.78 39 235683 1904 79506762
Infusion related reaction 41.28 9.78 458 235264 229779 79278887
Hepatitis B 41.27 9.78 82 235640 8250 79500416
Papilloma viral infection 41.26 9.78 37 235685 1697 79506969
Restlessness 41.10 9.78 46 235676 46446 79462220
Immunosuppression 41.03 9.78 106 235616 12697 79495969
CSF protein increased 41.01 9.78 32 235690 1208 79507458
Diabetic ketoacidosis 41.00 9.78 25 235697 34097 79474569
Fibromyalgia 40.93 9.78 80 235642 64260 79444406
Iron overload 40.89 9.78 38 235684 1826 79506840
Soft tissue disorder 40.53 9.78 51 235671 3464 79505202
Splenomegaly 40.23 9.78 144 235578 20610 79488056
Dry mouth 40.02 9.78 130 235592 87889 79420777
Cutaneous mucormycosis 39.81 9.78 17 235705 194 79508472
Fluid retention 39.26 9.78 93 235629 69716 79438950
Hepatosplenomegaly 39.23 9.78 67 235655 6002 79502664
Mucoepidermoid carcinoma of salivary gland 39.13 9.78 14 235708 95 79508571
Dysgeusia 39.12 9.78 68 235654 57109 79451557
Femur fracture 39.06 9.78 34 235688 38618 79470048
Mycobacterium chelonae infection 38.99 9.78 42 235680 2414 79506252
Sinus bradycardia 38.92 9.78 13 235709 25234 79483432
Chronic myeloid leukaemia 38.86 9.78 51 235671 3613 79505053
Rheumatoid lung 38.83 9.78 55 235667 4190 79504476
Haematochezia 38.78 9.78 131 235591 87514 79421152
Plasmacytoma 38.74 9.78 56 235666 4347 79504319
Lymphopenia 38.70 9.78 186 235536 30371 79478295
Bone marrow transplant 38.68 9.78 33 235689 1415 79507251
Tularaemia 38.63 9.78 14 235708 99 79508567
Epstein-Barr virus antibody positive 38.63 9.78 24 235698 623 79508043
Cutaneous T-cell lymphoma stage IV 38.45 9.78 11 235711 31 79508635
Fungaemia 38.38 9.78 57 235665 4534 79504132
Pneumonia viral 38.20 9.78 84 235638 9074 79499592
Respiratory depression 38.00 9.78 17 235705 27613 79481053
Diffuse alveolar damage 37.96 9.78 50 235672 3554 79505112
Hypoproteinaemia 37.87 9.78 53 235669 3993 79504673
Paroxysmal nocturnal haemoglobinuria 37.84 9.78 18 235704 269 79508397
Autoimmune neutropenia 37.68 9.78 23 235699 578 79508088
Ovarian failure 37.66 9.78 24 235698 652 79508014
Tumour lysis syndrome 37.48 9.78 12 235710 23927 79484739
Glomerulonephritis membranoproliferative 36.92 9.78 23 235699 600 79508066
Cardiac disorder 36.66 9.78 88 235634 65669 79442997
Renal cell carcinoma 36.58 9.78 68 235654 6510 79502156
Eyelid oedema 36.56 9.78 106 235616 13581 79495085
Night sweats 36.52 9.78 61 235661 52034 79456632
Acute disseminated encephalomyelitis 36.35 9.78 18 235704 295 79508371
Renal disorder 36.34 9.78 231 235491 41874 79466792
Porokeratosis 36.29 9.78 17 235705 245 79508421
Venous injury 36.26 9.78 25 235697 777 79507889
Blood beta-D-glucan increased 36.25 9.78 22 235700 547 79508119
Therapy interrupted 36.24 9.78 24 235698 31317 79477349
Ventricular fibrillation 36.17 9.78 25 235697 31901 79476765
Tuberculosis 36.17 9.78 113 235609 15085 79493581
Self-consciousness 36.11 9.78 13 235709 90 79508576
Neutrophil count decreased 35.99 9.78 149 235573 93810 79414856
Hiatus hernia 35.94 9.78 12 235710 23300 79485366
Eosinophilia 35.75 9.78 49 235673 45296 79463370
Klebsiella sepsis 35.63 9.78 46 235676 3206 79505460
Swollen tongue 35.62 9.78 44 235678 42526 79466140
Phaeohyphomycosis 35.55 9.78 29 235693 1168 79507498
Escherichia sepsis 35.44 9.78 78 235644 8430 79500236
Renal arteriosclerosis 35.35 9.78 18 235704 314 79508352
Brain stem syndrome 35.22 9.78 26 235696 902 79507764
Lactobacillus infection 35.21 9.78 19 235703 375 79508291
Intentional product use issue 35.21 9.78 284 235438 151828 79356838
Central nervous system fungal infection 35.13 9.78 20 235702 440 79508226
Overlap syndrome 35.11 9.78 27 235695 997 79507669
Haematemesis 35.00 9.78 63 235659 52201 79456465
Loss of personal independence in daily activities 34.98 9.78 460 235262 102120 79406546
Acute myeloid leukaemia 34.88 9.78 182 235540 30703 79477963
Haemolytic anaemia 34.85 9.78 124 235598 17696 79490970
Depressed mood 34.70 9.78 56 235666 48424 79460242
Keratoacanthoma 34.63 9.78 27 235695 1018 79507648
Blast crisis in myelogenous leukaemia 34.35 9.78 25 235697 848 79507818
Impaired work ability 34.31 9.78 8 235714 19673 79488993
Secondary immunodeficiency 34.27 9.78 45 235677 3189 79505477
Complications of transplanted liver 34.16 9.78 19 235703 399 79508267
Papilloedema 34.12 9.78 64 235658 6169 79502497
Fibroadenoma of breast 34.07 9.78 18 235704 340 79508326
Product use issue 33.91 9.78 836 234886 208986 79299680
Tremor 33.89 9.78 330 235392 169753 79338913
Haemorrhagic cyst 33.72 9.78 17 235705 290 79508376
Psoriasis area severity index increased 33.66 9.78 13 235709 112 79508554
Fungal test positive 33.49 9.78 27 235695 1069 79507597
West Nile viral infection 33.44 9.78 26 235696 976 79507690
Atypical mycobacterial infection 33.44 9.78 33 235689 1710 79506956
Maternal exposure during pregnancy 33.43 9.78 251 235471 136287 79372379
Dyspnoea exertional 33.40 9.78 138 235584 86935 79421731
Torsade de pointes 33.37 9.78 8 235714 19304 79489362
Cytomegalovirus gastrointestinal infection 33.14 9.78 20 235702 492 79508174
Ankylosing spondylitis 33.06 9.78 95 235627 12110 79496556
Epidermodysplasia verruciformis 33.06 9.78 18 235704 362 79508304
Laser therapy 32.97 9.78 9 235713 20 79508646
Irritability 32.90 9.78 44 235678 41100 79467566
Pneumonia pseudomonal 32.74 9.78 61 235661 5850 79502816
Behcet's syndrome 32.67 9.78 9 235713 21 79508645
Nephrolithiasis 32.42 9.78 68 235654 53223 79455443
Lethargy 32.34 9.78 127 235595 81165 79427501
Oliguria 32.33 9.78 114 235608 16195 79492471
Poikiloderma 32.07 9.78 18 235704 385 79508281
Infertility 32.05 9.78 22 235700 679 79507987
Staphylococcal bacteraemia 32.04 9.78 94 235628 12124 79496542
Clonal evolution 31.97 9.78 15 235707 217 79508449
Schizophrenia 31.91 9.78 4 235718 15436 79493230
Necrosis 31.88 9.78 80 235642 9413 79499253
Withdrawal syndrome 31.82 9.78 20 235702 26834 79481832
Urinary tract infection 31.63 9.78 596 235126 273916 79234750
Blindness cortical 31.62 9.78 25 235697 962 79507704
Osmotic demyelination syndrome 31.57 9.78 30 235692 1483 79507183
Blood pressure decreased 31.47 9.78 169 235553 99297 79409369
T-cell lymphoma 31.40 9.78 28 235694 1275 79507391
Upper gastrointestinal haemorrhage 31.34 9.78 46 235676 41334 79467332
Underdose 31.33 9.78 31 235691 33120 79475546
Transurethral bladder resection 31.30 9.78 7 235715 3 79508663
Generalised oedema 31.25 9.78 146 235576 23563 79485103
Abnormal behaviour 31.15 9.78 37 235685 36384 79472282
Drug tolerance 31.14 9.78 75 235647 8600 79500066
Cytomegalovirus enterocolitis 31.13 9.78 31 235691 1624 79507042
Tuberculosis gastrointestinal 31.04 9.78 20 235702 554 79508112
Dilatation intrahepatic duct acquired 31.03 9.78 22 235700 716 79507950
Drug level changed 31.01 9.78 20 235702 555 79508111
Nightmare 31.00 9.78 19 235703 25842 79482824
Lepromatous leprosy 30.95 9.78 11 235711 73 79508593
Blood calcium decreased 30.94 9.78 29 235693 31790 79476876
Chronic myeloid leukaemia recurrent 30.92 9.78 16 235706 289 79508377
Rotavirus infection 30.92 9.78 22 235700 720 79507946
Pneumonia bacterial 30.79 9.78 126 235596 19205 79489461
Reticulocytosis 30.69 9.78 19 235703 490 79508176
Neoplasm progression 30.56 9.78 67 235655 51615 79457051
Anaemia 30.55 9.78 1043 234679 443972 79064694
Cryptococcal meningoencephalitis 30.34 9.78 15 235707 245 79508421
Cerebral fungal infection 30.33 9.78 18 235704 429 79508237
Peripheral swelling 30.26 9.78 588 235134 269029 79239637
Lymphadenectomy 30.23 9.78 27 235695 1232 79507434
Sleep apnoea syndrome 30.21 9.78 38 235684 36440 79472226
Sweat gland tumour 30.05 9.78 19 235703 509 79508157
Drug level fluctuating 29.96 9.78 22 235700 757 79507909
Skin laceration 29.85 9.78 25 235697 28937 79479729
Papule 29.84 9.78 67 235655 7340 79501326
Erythema infectiosum 29.81 9.78 14 235708 203 79508463
Renal tubular injury 29.59 9.78 29 235693 1490 79507176
Extrapyramidal disorder 29.59 9.78 15 235707 22664 79486002
Therapeutic product effect variable 29.54 9.78 33 235689 1976 79506690
Bowen's disease 29.50 9.78 12 235710 120 79508546
Hyperbilirubinaemia 29.44 9.78 147 235575 24371 79484295
Pruritus 29.21 9.78 916 234806 393732 79114934
Urine output decreased 29.12 9.78 118 235604 17904 79490762
Lupus nephritis 29.05 9.78 40 235682 2968 79505698
Adverse drug reaction 28.85 9.78 100 235622 66292 79442374
Hip arthroplasty 28.83 9.78 38 235684 35718 79472948
Abnormal sensation in eye 28.82 9.78 32 235690 1903 79506763
Small intestinal obstruction 28.78 9.78 23 235699 27249 79481417
Renal vein thrombosis 28.69 9.78 19 235703 552 79508114
Dysarthria 28.62 9.78 103 235619 67519 79441147
Urinary incontinence 28.59 9.78 48 235674 40861 79467805
Nephropathy 28.54 9.78 78 235644 9660 79499006
Epstein-Barr virus test positive 28.49 9.78 25 235697 1114 79507552
Encephalitis fungal 28.34 9.78 13 235709 178 79508488
Varicella 28.33 9.78 39 235683 2893 79505773
Fear 28.00 9.78 15 235707 21971 79486695
Peripheral T-cell lymphoma unspecified 27.70 9.78 20 235702 670 79507996
IgA nephropathy 27.65 9.78 30 235692 1738 79506928
Hypomagnesaemia 27.59 9.78 61 235661 46850 79461816
Gastroenteritis adenovirus 27.59 9.78 16 235706 365 79508301
Renal vessel disorder 27.58 9.78 15 235707 301 79508365
Erectile dysfunction 27.55 9.78 5 235717 14659 79494007
Stenotrophomonas infection 27.55 9.78 44 235678 3729 79504937
Treatment noncompliance 27.54 9.78 72 235650 52196 79456470
Angina pectoris 27.46 9.78 71 235651 51661 79457005
Peripheral artery aneurysm 27.44 9.78 17 235705 439 79508227
Epicondylitis 27.37 9.78 33 235689 2145 79506521
Feeling hot 27.31 9.78 88 235634 59646 79449020
Cutaneous sporotrichosis 27.29 9.78 9 235713 46 79508620
Adenovirus reactivation 27.28 9.78 16 235706 373 79508293
Myopathy toxic 27.26 9.78 24 235698 1074 79507592
Trichophytosis 27.24 9.78 16 235706 374 79508292
Erythema 27.18 9.78 858 234864 222432 79286234
Removal of renal transplant 27.12 9.78 8 235714 26 79508640
Guttate psoriasis 27.07 9.78 17 235705 450 79508216
Pneumonia aspiration 27.03 9.78 104 235618 66863 79441803
Productive cough 26.89 9.78 152 235570 88179 79420487
Escherichia urinary tract infection 26.86 9.78 96 235626 13729 79494937
Cat scratch disease 26.83 9.78 16 235706 385 79508281
Arrhythmia 26.82 9.78 92 235630 61180 79447486
Skin toxicity 26.81 9.78 69 235653 8245 79500421
Fungal sepsis 26.80 9.78 30 235692 1800 79506866
Disturbance in attention 26.75 9.78 70 235652 50731 79457935
Endocrine ophthalmopathy 26.74 9.78 20 235702 708 79507958
Amnesia 26.71 9.78 96 235626 62961 79445705
Ophthalmic herpes simplex 26.69 9.78 20 235702 710 79507956
Angiosarcoma 26.64 9.78 17 235705 463 79508203
Blood glucose decreased 26.60 9.78 23 235699 26211 79482455
Glomerulonephritis proliferative 26.57 9.78 16 235706 392 79508274
Rib fracture 26.56 9.78 26 235696 27921 79480745
Lower limb fracture 26.54 9.78 18 235704 23197 79485469
Throat tightness 26.48 9.78 26 235696 27881 79480785
Therapeutic product effect incomplete 26.47 9.78 576 235146 141069 79367597
Normal newborn 26.31 9.78 62 235660 7010 79501656
Capillary leak syndrome 26.26 9.78 44 235678 3881 79504785
Non-Hodgkin's lymphoma 26.11 9.78 27 235695 1480 79507186
Arteriosclerosis coronary artery 26.05 9.78 10 235712 17806 79490860
Philadelphia positive chronic myeloid leukaemia 25.99 9.78 12 235710 167 79508499
Instillation site reaction 25.95 9.78 15 235707 340 79508326
Red blood cell abnormality 25.93 9.78 20 235702 742 79507924
Pneumonia herpes viral 25.92 9.78 12 235710 168 79508498
Renal mass 25.84 9.78 40 235682 3300 79505366
Intracranial pressure increased 25.75 9.78 68 235654 8254 79500412
Organising pneumonia 25.72 9.78 81 235641 10858 79497808
Pregnancy 25.50 9.78 25 235697 26826 79481840
NPM1 gene mutation 25.50 9.78 11 235711 129 79508537
Hypertensive encephalopathy 25.46 9.78 22 235700 960 79507706
Endotracheal intubation 25.43 9.78 48 235674 4649 79504017
Cytomegalovirus hepatitis 25.42 9.78 20 235702 764 79507902
Tongue ulceration 25.42 9.78 45 235677 4148 79504518
Therapy cessation 25.40 9.78 45 235677 37517 79471149
Bronchitis 25.38 9.78 255 235467 130389 79378277
Accidental overdose 25.36 9.78 49 235673 39532 79469134
Migraine 25.33 9.78 153 235569 87340 79421326
Anaplastic large cell lymphoma T- and null-cell types 25.27 9.78 11 235711 132 79508534
Achromobacter infection 25.20 9.78 11 235711 133 79508533
Bronchospasm 24.96 9.78 22 235700 24837 79483829
Thrombosis 24.91 9.78 146 235576 83954 79424712
Eyelid disorder 24.91 9.78 30 235692 1948 79506718
Device issue 24.87 9.78 26 235696 27082 79481584
Bone pain 24.87 9.78 83 235639 55659 79453007
White blood cell count decreased 24.49 9.78 400 235322 187888 79320778
Eye infection toxoplasmal 24.47 9.78 17 235705 535 79508131
Pulmonary alveolar haemorrhage 24.38 9.78 82 235640 11375 79497291
Frequent bowel movements 24.22 9.78 31 235691 29508 79479158
Ureaplasma infection 24.19 9.78 22 235700 1028 79507638
Marrow hyperplasia 24.11 9.78 27 235695 1621 79507045
Congenital coronary artery malformation 24.07 9.78 10 235712 106 79508560
Hepatomegaly 23.98 9.78 115 235607 18759 79489907
Restless legs syndrome 23.75 9.78 15 235707 20077 79488589
Immune thrombocytopenia 23.73 9.78 110 235612 17695 79490971
Ill-defined disorder 23.67 9.78 107 235615 65768 79442898
Chloroma 23.59 9.78 19 235703 751 79507915
Guillain-Barre syndrome 23.53 9.78 69 235653 8896 79499770
Atypical mycobacterial pneumonia 23.45 9.78 11 235711 159 79508507
Oesophageal squamous cell carcinoma 23.42 9.78 16 235706 490 79508176
Laryngeal disorder 23.38 9.78 22 235700 1074 79507592
Hypophosphataemia 23.36 9.78 15 235707 19898 79488768
Retinal scar 23.36 9.78 15 235707 413 79508253
Retinal haemorrhage 23.28 9.78 65 235657 8152 79500514
Keratitis 23.19 9.78 44 235678 4278 79504388
Parvovirus infection 23.17 9.78 18 235704 675 79507991
Stress 23.16 9.78 139 235583 79473 79429193
Urticaria 23.16 9.78 714 235008 184487 79324179
Arterial disorder 23.15 9.78 29 235693 1961 79506705
Product delivery mechanism issue 23.09 9.78 11 235711 165 79508501
Disseminated toxoplasmosis 22.93 9.78 12 235710 222 79508444
Visceral leishmaniasis 22.93 9.78 22 235700 1101 79507565
Anger 22.92 9.78 11 235711 17151 79491515
Debridement 22.85 9.78 27 235695 1718 79506948
Bile duct stenosis 22.85 9.78 29 235693 1987 79506679
Disability 22.82 9.78 11 235711 17109 79491557
Perinephric collection 22.82 9.78 14 235708 355 79508311
Blood immunoglobulin M increased 22.82 9.78 24 235698 1342 79507324
Morphoea 22.70 9.78 15 235707 434 79508232
Rash pruritic 22.69 9.78 317 235405 71312 79437354
Cytomegalovirus enteritis 22.67 9.78 19 235703 795 79507871
Papilloma 22.65 9.78 14 235708 360 79508306
Phototherapy 22.61 9.78 7 235715 28 79508638
Procedural pain 22.49 9.78 21 235701 23063 79485603
Diffuse large B-cell lymphoma stage IV 22.42 9.78 16 235706 526 79508140
Sinus disorder 22.41 9.78 20 235702 22444 79486222
Prostate cancer 22.37 9.78 40 235682 33228 79475438
Adrenal suppression 22.34 9.78 24 235698 1375 79507291
Lung abscess 22.23 9.78 42 235680 4070 79504596
Injection site warmth 22.18 9.78 8 235714 14799 79493867
Burkholderia cepacia complex infection 22.09 9.78 13 235709 305 79508361
Human ehrlichiosis 22.03 9.78 16 235706 541 79508125
Wrong technique in product usage process 22.02 9.78 128 235594 73747 79434919
Plasma cell myeloma 21.96 9.78 82 235640 53177 79455489
Middle insomnia 21.92 9.78 10 235712 16059 79492607
Jaw fracture 21.77 9.78 35 235687 2982 79505684
Meningitis cryptococcal 21.74 9.78 38 235684 3468 79505198
Cytomegalovirus oesophagitis 21.71 9.78 18 235704 742 79507924
Laryngitis viral 21.67 9.78 8 235714 60 79508606
Alopecia scarring 21.62 9.78 9 235713 96 79508570
Ulcerative keratitis 21.61 9.78 39 235683 3650 79505016
Gastropleural fistula 21.56 9.78 8 235714 61 79508605
Device malfunction 21.51 9.78 19 235703 21429 79487237
Hepatic failure 21.50 9.78 276 235446 60936 79447730
Limbic encephalitis 21.48 9.78 19 235703 856 79507810
Drug level decreased 21.47 9.78 92 235630 14310 79494356
Corynebacterium infection 21.45 9.78 23 235699 1315 79507351
Reversible cerebral vasoconstriction syndrome 21.43 9.78 35 235687 3022 79505644
Idiopathic intracranial hypertension 21.39 9.78 36 235686 3186 79505480
Pseudomonas aeruginosa meningitis 21.35 9.78 7 235715 35 79508631
Muscle twitching 21.35 9.78 25 235697 24739 79483927
Rebound effect 21.30 9.78 58 235664 7168 79501498
Oral disorder 21.26 9.78 72 235650 10023 79498643
Intervertebral disc degeneration 21.26 9.78 10 235712 15775 79492891
Tardive dyskinesia 21.22 9.78 3 235719 10568 79498098
Glomerulonephritis minimal lesion 21.16 9.78 18 235704 769 79507897
Papillary renal cell carcinoma 21.12 9.78 12 235710 263 79508403
Hepatitis B reactivation 21.06 9.78 52 235670 6056 79502610
Viral infection 21.04 9.78 207 235515 42809 79465857
Gastroenteritis norovirus 21.02 9.78 35 235687 3071 79505595
Biliary hamartoma 20.95 9.78 6 235716 17 79508649
Ewing's sarcoma recurrent 20.95 9.78 6 235716 17 79508649
Joint stiffness 20.94 9.78 57 235665 40773 79467893
Injection site reaction 20.90 9.78 87 235635 54698 79453968
Stomatitis 20.87 9.78 575 235147 146182 79362484
Disorientation 20.79 9.78 105 235617 62671 79445995
Dysplasia 20.78 9.78 23 235699 1363 79507303
Pollakiuria 20.75 9.78 50 235672 37267 79471399
Alpha haemolytic streptococcal infection 20.74 9.78 30 235692 2330 79506336
Penicillium infection 20.72 9.78 12 235710 273 79508393
Cold sweat 20.71 9.78 15 235707 18684 79489982
Atypical haemolytic uraemic syndrome 20.66 9.78 20 235702 1012 79507654
Vascular graft complication 20.64 9.78 10 235712 156 79508510
Troponin increased 20.62 9.78 16 235706 19239 79489427
Urinary tract infection viral 20.60 9.78 8 235714 70 79508596
Megakaryocytes increased 20.60 9.78 9 235713 109 79508557
Stevens-Johnson syndrome 20.60 9.78 54 235668 39112 79469554
Weber tuning fork test abnormal 20.53 9.78 9 235713 110 79508556
Embryonal rhabdomyosarcoma 20.43 9.78 7 235715 41 79508625
Anogenital warts 20.41 9.78 19 235703 915 79507751
Skin neoplasm excision 20.37 9.78 20 235702 1030 79507636
Psychotic disorder 20.34 9.78 59 235663 41343 79467323
Injection site papule 20.34 9.78 19 235703 919 79507747
Sporotrichosis 20.32 9.78 9 235713 113 79508553
Lichenification 20.27 9.78 18 235704 815 79507851
Chronic kidney disease 20.24 9.78 291 235431 65863 79442803
Hepatitis viral 20.24 9.78 20 235702 1038 79507628
Vision blurred 20.22 9.78 432 235290 105466 79403200
Oropharyngeal pain 20.19 9.78 216 235506 109137 79399529
Muscular dystrophy 20.19 9.78 10 235712 164 79508502
Colectomy 20.18 9.78 36 235686 3338 79505328
Toxic encephalopathy 20.18 9.78 77 235645 11363 79497303
Renal tubular disorder 20.07 9.78 53 235669 6433 79502233
Haematotoxicity 20.04 9.78 95 235627 15424 79493242
Oral lichenoid reaction 19.97 9.78 9 235713 118 79508548
Angioedema 19.95 9.78 137 235585 75898 79432768
Hepatic enzyme increased 19.95 9.78 400 235322 182210 79326456
Weight fluctuation 19.85 9.78 5 235717 11670 79496996
Rash pustular 19.85 9.78 76 235646 11235 79497431
Feeling cold 19.81 9.78 34 235688 28695 79479971
Tinnitus 19.79 9.78 66 235656 44267 79464399
Mania 19.77 9.78 15 235707 18245 79490421
Device leakage 19.76 9.78 4 235718 10852 79497814
Rectal cancer metastatic 19.57 9.78 14 235708 462 79508204
Pneumonia klebsiella 19.56 9.78 45 235677 5009 79503657
Concomitant disease aggravated 19.55 9.78 84 235638 13083 79495583
Hyperkalaemia 19.53 9.78 230 235492 114168 79394498
Blood cholesterol increased 19.51 9.78 156 235566 83564 79425102
Malignant neoplasm of conjunctiva 19.50 9.78 7 235715 48 79508618
Mental status changes 19.43 9.78 117 235605 66842 79441824
Limb injury 19.41 9.78 36 235686 29492 79479174
Prescribed underdose 19.38 9.78 36 235686 29478 79479188
CSF cell count increased 19.32 9.78 9 235713 128 79508538
Punctal plug insertion 19.31 9.78 4 235718 0 79508666
Gingivectomy 19.31 9.78 4 235718 0 79508666
Candida sepsis 19.31 9.78 30 235692 2483 79506183
Cataract 19.31 9.78 274 235448 61846 79446820
Therapy partial responder 19.29 9.78 102 235620 17295 79491371
Product quality issue 19.25 9.78 45 235677 33895 79474771
Muscle spasticity 19.25 9.78 21 235701 21454 79487212
Cholelithiasis 19.25 9.78 85 235637 52579 79456087
Body temperature increased 19.23 9.78 67 235655 44353 79464313
Injection site induration 19.22 9.78 3 235719 9816 79498850
Infection 19.17 9.78 886 234836 240826 79267840
Fibrosis 19.16 9.78 46 235676 5263 79503403
Skin papilloma 19.14 9.78 49 235673 5837 79502829
Neoplasm recurrence 19.12 9.78 40 235682 4174 79504492
Hypotony of eye 19.12 9.78 11 235711 247 79508419
Dystonia 19.10 9.78 21 235701 21378 79487288
Infective tenosynovitis 19.03 9.78 13 235709 398 79508268
Blood glucose abnormal 19.01 9.78 4 235718 10562 79498104
Leukaemia in remission 19.01 9.78 5 235717 9 79508657
Epstein-Barr virus antigen positive 19.00 9.78 8 235714 88 79508578
Lip dry 18.94 9.78 11 235711 15407 79493259
Skin disorder 18.94 9.78 168 235554 33775 79474891
Hip fracture 18.92 9.78 39 235683 30722 79477944
Mouth ulceration 18.90 9.78 185 235537 38209 79470457
Splenic abscess 18.89 9.78 15 235707 581 79508085
Respiratory syncytial virus infection 18.88 9.78 66 235656 9336 79499330
Swelling face 18.84 9.78 128 235594 71084 79437582
Vaginal haemorrhage 18.83 9.78 22 235700 21795 79486871
Dysphagia 18.82 9.78 251 235471 121885 79386781
Cryptococcal cutaneous infection 18.78 9.78 10 235712 192 79508474
Atrioventricular block 18.75 9.78 9 235713 14032 79494634
Haemorrhoids 18.72 9.78 36 235686 29092 79479574
Pneumonia influenzal 18.69 9.78 32 235690 2872 79505794
Plasmodium falciparum infection 18.68 9.78 8 235714 92 79508574
Skin injury 18.68 9.78 35 235687 3371 79505295
Depressed level of consciousness 18.63 9.78 189 235533 96463 79412203
Hyperkeratosis 18.61 9.78 58 235664 7732 79500934
Gastroenteritis clostridial 18.61 9.78 18 235704 910 79507756
Nasal congestion 18.60 9.78 141 235581 76411 79432255
Malabsorption 18.60 9.78 44 235678 4988 79503678
Genital cyst 18.57 9.78 7 235715 56 79508610
Liver injury 18.57 9.78 95 235627 56519 79452147
Erythema multiforme 18.48 9.78 15 235707 17636 79491030
Coombs direct test positive 18.47 9.78 13 235709 418 79508248
Hilar lymphadenopathy 18.37 9.78 25 235697 1834 79506832
Keratolysis exfoliativa acquired 18.35 9.78 5 235717 11 79508655
Head discomfort 18.31 9.78 10 235712 14492 79494174
Ureteral necrosis 18.31 9.78 8 235714 97 79508569
Exercise tolerance increased 18.30 9.78 6 235716 30 79508636
Blood immunoglobulin A decreased 18.24 9.78 22 235700 1431 79507235
Emotional distress 18.19 9.78 59 235663 39910 79468756
Myasthenic syndrome 18.15 9.78 17 235705 825 79507841
Transplant abscess 18.14 9.78 6 235716 31 79508635
Clostridium difficile colitis 18.13 9.78 160 235562 32123 79476543
Tooth hypoplasia 18.11 9.78 10 235712 207 79508459
Cyanosis 18.10 9.78 29 235693 25153 79483513
Chills 18.10 9.78 349 235373 159885 79348781
Sudden death 18.07 9.78 24 235698 22487 79486179
Thirst 18.07 9.78 17 235705 18602 79490064
Haematuria 18.06 9.78 295 235427 68541 79440125
Malacoplakia 18.03 9.78 15 235707 621 79508045
Cancer surgery 18.03 9.78 17 235705 832 79507834
Ventricular extrasystoles 17.96 9.78 19 235703 19685 79488981
Chronic sinusitis 17.94 9.78 8 235714 13018 79495648
H1N1 influenza 17.88 9.78 29 235693 2490 79506176
Muscle fatigue 17.87 9.78 35 235687 3484 79505182
Gastroenteritis cryptosporidial 17.86 9.78 11 235711 281 79508385
Disseminated Bacillus Calmette-Guerin infection 17.85 9.78 10 235712 213 79508453
Hyperglycaemia 17.83 9.78 128 235594 70207 79438459
Blood urine present 17.83 9.78 22 235700 21275 79487391
Injection site mass 17.81 9.78 20 235702 20164 79488502
Ocular discomfort 17.80 9.78 43 235679 4940 79503726
Renal infarct 17.78 9.78 30 235692 2661 79506005
Vasogenic cerebral oedema 17.76 9.78 22 235700 1471 79507195
Squamous cell carcinoma of the tongue 17.75 9.78 16 235706 739 79507927
Gallbladder rupture 17.75 9.78 18 235704 964 79507702
Salivary hypersecretion 17.69 9.78 10 235712 14214 79494452
Eyelid irritation 17.68 9.78 13 235709 448 79508218
Toxic skin eruption 17.66 9.78 24 235698 22269 79486397
Illness 17.65 9.78 74 235648 46437 79462229
Infection in an immunocompromised host 17.64 9.78 21 235701 1347 79507319
Corneal perforation 17.60 9.78 16 235706 747 79507919
Pulseless electrical activity 17.54 9.78 10 235712 14150 79494516
Still's disease 17.50 9.78 5 235717 14 79508652
Breast cancer female 17.49 9.78 6 235716 11455 79497211
Mycobacterium marinum infection 17.48 9.78 13 235709 456 79508210
Enterococcal bacteraemia 17.42 9.78 32 235690 3036 79505630
Full blood count decreased 17.36 9.78 33 235689 26786 79481880
Trichosporon infection 17.35 9.78 18 235704 990 79507676
Endocarditis bacterial 17.34 9.78 22 235700 1507 79507159
Brain oedema 17.31 9.78 131 235591 25132 79483534
Asthenopia 17.30 9.78 28 235694 2399 79506267
Pityriasis rubra pilaris 17.28 9.78 8 235714 112 79508554
Periorbital infection 17.28 9.78 8 235714 112 79508554
Proteus infection 17.28 9.78 26 235696 2092 79506574
Lung consolidation 17.27 9.78 62 235660 8885 79499781
Retroperitoneal neoplasm 17.25 9.78 6 235716 37 79508629
Intestinal obstruction 17.24 9.78 67 235655 42953 79465713
Human herpesvirus 6 infection reactivation 17.22 9.78 14 235708 561 79508105
Human herpesvirus 6 encephalitis 17.20 9.78 15 235707 663 79508003
Dermatitis atopic 17.18 9.78 67 235655 9989 79498677
Passenger lymphocyte syndrome 17.16 9.78 8 235714 114 79508552
Central nervous system vasculitis 17.15 9.78 21 235701 1387 79507279
Anal incontinence 17.15 9.78 17 235705 18151 79490515
Retinopathy haemorrhagic 17.12 9.78 7 235715 71 79508595
Foot fracture 17.08 9.78 24 235698 21957 79486709
Parenteral nutrition 17.04 9.78 7 235715 72 79508594
Instillation site irritation 17.04 9.78 7 235715 72 79508594
Disseminated varicella zoster vaccine virus infection 17.03 9.78 8 235714 116 79508550
Faeces discoloured 17.02 9.78 38 235684 29089 79479577
Colitis herpes 17.01 9.78 5 235717 16 79508650
Pneumoretroperitoneum 16.99 9.78 9 235713 171 79508495
Reticulocyte count decreased 16.97 9.78 17 235705 897 79507769
Tonsillar hypertrophy 16.97 9.78 22 235700 1540 79507126
Adenomatous polyposis coli 16.79 9.78 10 235712 240 79508426
Stress cardiomyopathy 16.78 9.78 6 235716 11160 79497506
Acanthosis 16.77 9.78 13 235709 486 79508180
Nail disorder 16.76 9.78 7 235715 11845 79496821
Blood immunoglobulin G increased 16.75 9.78 31 235691 2958 79505708
Fracture 16.74 9.78 24 235698 21777 79486889
Injection site rash 16.72 9.78 17 235705 17937 79490729
Joint ankylosis 16.71 9.78 26 235696 2154 79506512
Neuroendocrine carcinoma of the skin 16.69 9.78 20 235702 1292 79507374
Injection site swelling 16.67 9.78 77 235645 47055 79461611
Acanthamoeba infection 16.63 9.78 13 235709 492 79508174
Septic vasculitis 16.55 9.78 4 235718 4 79508662
Eye inflammation 16.49 9.78 49 235673 6364 79502302
Septic embolus 16.48 9.78 25 235697 2026 79506640
Meningococcal sepsis 16.46 9.78 7 235715 79 79508587
CSF pressure increased 16.46 9.78 10 235712 249 79508417
Eyelids pruritus 16.38 9.78 17 235705 936 79507730
Diarrhoea haemorrhagic 16.36 9.78 80 235642 13154 79495512
Non-cardiac chest pain 16.35 9.78 4 235718 9520 79499146
Burkitt's lymphoma stage III 16.35 9.78 5 235717 19 79508647
Injection site bruising 16.34 9.78 64 235658 40938 79467728
Viral myocarditis 16.34 9.78 13 235709 505 79508161
Apathy 16.31 9.78 9 235713 12968 79495698
Chest expansion decreased 16.31 9.78 9 235713 186 79508480
Lung neoplasm 16.31 9.78 52 235670 7017 79501649
Device related infection 16.28 9.78 164 235558 34130 79474536
Eye abscess 16.27 9.78 11 235711 331 79508335
Anti-thyroid antibody 16.25 9.78 6 235716 45 79508621
Exposure during pregnancy 16.25 9.78 206 235516 100926 79407740
Blood immunoglobulin G decreased 16.23 9.78 33 235689 3376 79505290
Benign prostatic hyperplasia 16.20 9.78 7 235715 11605 79497061
Sinus congestion 16.19 9.78 21 235701 19875 79488791
Rhinovirus infection 16.12 9.78 56 235666 7897 79500769
Gastrointestinal candidiasis 16.11 9.78 12 235710 422 79508244
Live birth 16.08 9.78 19 235703 18725 79489941
Obstructive airways disorder 16.07 9.78 44 235678 31415 79477251
Pyoderma gangrenosum 16.07 9.78 37 235685 4121 79504545
Dizziness postural 16.05 9.78 7 235715 11542 79497124
Disseminated varicella zoster virus infection 16.05 9.78 14 235708 619 79508047
Vesicoureteric reflux 16 9.78 8 235714 134 79508532
Infusion site extravasation 15.94 9.78 5 235717 10103 79498563
Gastrointestinal mucormycosis 15.92 9.78 12 235710 430 79508236
Central venous pressure increased 15.89 9.78 8 235714 136 79508530
Haemorrhage intracranial 15.85 9.78 132 235590 26061 79482605
Toxic shock syndrome 15.82 9.78 19 235703 1230 79507436
Primary effusion lymphoma 15.81 9.78 6 235716 49 79508617
Cytomegalovirus test 15.81 9.78 6 235716 49 79508617
Complication associated with device 15.81 9.78 17 235705 17479 79491187
MELAS syndrome 15.77 9.78 9 235713 199 79508467
Central nervous system lymphoma 15.77 9.78 26 235696 2263 79506403
Peritonitis 15.77 9.78 139 235583 27897 79480769
Lichen planus 15.71 9.78 29 235693 2762 79505904
Renal necrosis 15.68 9.78 10 235712 272 79508394
Azotaemia 15.68 9.78 57 235665 8219 79500447
Acarodermatitis 15.67 9.78 20 235702 1378 79507288
Adenoviral encephalitis 15.66 9.78 4 235718 6 79508660
Lesion excision 15.64 9.78 8 235714 141 79508525
Mass excision 15.62 9.78 11 235711 354 79508312
Aortitis salmonella 15.59 9.78 5 235717 23 79508643
Diabetes mellitus inadequate control 15.58 9.78 30 235692 24234 79484432
Poor quality sleep 15.56 9.78 27 235695 22695 79485971
Tongue neoplasm 15.52 9.78 7 235715 92 79508574
Bradyphrenia 15.51 9.78 6 235716 10634 79498032
Increased appetite 15.51 9.78 8 235714 11970 79496696
Diabetic macroangiopathy 15.49 9.78 8 235714 144 79508522
Human herpes virus 6 serology positive 15.41 9.78 9 235713 208 79508458
Post procedural urine leak 15.39 9.78 8 235714 146 79508520
Intervertebral disc protrusion 15.35 9.78 29 235693 23592 79485074
Endocarditis 15.27 9.78 67 235655 10530 79498136
Laboratory test abnormal 15.27 9.78 38 235684 28010 79480656
Paraesthesia oral 15.27 9.78 23 235699 20448 79488218
Device occlusion 15.25 9.78 8 235714 11858 79496808
Urinary bladder toxicity 15.25 9.78 5 235717 25 79508641
Globulins decreased 15.24 9.78 12 235710 459 79508207
Trichodysplasia spinulosa 15.20 9.78 15 235707 777 79507889
Candida pneumonia 15.17 9.78 14 235708 667 79507999
Autoimmune disorder 15.17 9.78 16 235706 16596 79492070
Pneumonia respiratory syncytial viral 15.14 9.78 23 235699 1867 79506799
Renal cell carcinoma stage III 15.09 9.78 5 235717 26 79508640
Hippocampal sclerosis 15.05 9.78 8 235714 153 79508513
Lung lobectomy 15.05 9.78 8 235714 153 79508513
Malignant sweat gland neoplasm 15.02 9.78 6 235716 57 79508609
Throat irritation 15.02 9.78 66 235656 40880 79467786
Peripheral coldness 15.01 9.78 15 235707 15955 79492711
Hepatotoxicity 14.97 9.78 224 235498 51128 79457538
Blood thyroid stimulating hormone increased 14.96 9.78 5 235717 9703 79498963
Caesarean section 14.94 9.78 75 235647 12460 79496206
Prostatic specific antigen increased 14.91 9.78 6 235716 10380 79498286
Heparin-induced thrombocytopenia 14.90 9.78 5 235717 9677 79498989
Gastrointestinal stromal tumour 14.90 9.78 22 235700 1741 79506925
Enterocolitis viral 14.89 9.78 11 235711 382 79508284
Apnoea 14.88 9.78 8 235714 11696 79496970
Cerebral vasoconstriction 14.88 9.78 20 235702 1450 79507216
Spermatozoa progressive motility decreased 14.84 9.78 6 235716 59 79508607
Keratitis bacterial 14.82 9.78 8 235714 158 79508508
Supraventricular tachycardia 14.82 9.78 25 235697 21245 79487421
Serratia infection 14.77 9.78 22 235700 1754 79506912
Mobility decreased 14.76 9.78 263 235459 121912 79386754
Tooth extraction 14.76 9.78 7 235715 10988 79497678
Lacrimation decreased 14.74 9.78 11 235711 388 79508278
Red cell distribution width increased 14.69 9.78 14 235708 15228 79493438
Hyperfibrinogenaemia 14.69 9.78 7 235715 105 79508561
Bile duct stent insertion 14.66 9.78 6 235716 61 79508605
Gliosis 14.65 9.78 12 235710 486 79508180
Retrograde portal vein flow 14.62 9.78 4 235718 9 79508657
Undifferentiated sarcoma 14.62 9.78 4 235718 9 79508657
Nerve conduction studies abnormal 14.60 9.78 8 235714 163 79508503
CSF white blood cell count increased 14.57 9.78 7 235715 107 79508559
Type IIb hyperlipidaemia 14.49 9.78 5 235717 30 79508636
Cytomegalovirus gastrointestinal ulcer 14.49 9.78 6 235716 63 79508603
Choledocholithotomy 14.48 9.78 3 235719 0 79508666
Nail candida 14.48 9.78 3 235719 0 79508666
Renal cell carcinoma stage II 14.48 9.78 3 235719 0 79508666
Hepatitis B e antigen 14.48 9.78 3 235719 0 79508666
Biliary sphincterotomy 14.48 9.78 3 235719 0 79508666
Peritoneal lavage 14.48 9.78 3 235719 0 79508666
Concussion 14.46 9.78 5 235717 9498 79499168
Neuroendocrine tumour of the lung metastatic 14.46 9.78 7 235715 109 79508557
Hypothyroidism 14.45 9.78 93 235629 52299 79456367
Myelodysplastic syndrome 14.43 9.78 145 235577 30156 79478510
Flatulence 14.41 9.78 71 235651 42653 79466013
Liver abscess 14.39 9.78 45 235677 6009 79502657
Pancreas transplant rejection 14.39 9.78 10 235712 315 79508351
Rheumatic disorder 14.36 9.78 30 235692 3128 79505538
Antimitochondrial antibody positive 14.34 9.78 7 235715 111 79508555
Walking aid user 14.34 9.78 6 235716 10142 79498524
Electrocardiogram abnormal 14.32 9.78 17 235705 16720 79491946
Symptom recurrence 14.24 9.78 25 235697 2289 79506377
Pulse absent 14.24 9.78 6 235716 10097 79498569
Mood swings 14.19 9.78 23 235699 19857 79488809
Hodgkin's disease 14.17 9.78 15 235707 845 79507821
Mantle cell lymphoma stage IV 14.17 9.78 6 235716 67 79508599
Hepatic enzyme abnormal 14.13 9.78 53 235669 7757 79500909
Urticaria pressure 14.09 9.78 5 235717 33 79508633
Eccrine squamous syringometaplasia 14.09 9.78 5 235717 33 79508633
Ketoacidosis 14.08 9.78 3 235719 7851 79500815
Eye infection fungal 14.02 9.78 12 235710 517 79508149
Moraxella infection 14.00 9.78 13 235709 624 79508042
Dermatitis acneiform 13.98 9.78 6 235716 9987 79498679
Corneal lesion 13.93 9.78 6 235716 70 79508596
Impetigo herpetiformis 13.91 9.78 7 235715 119 79508547
Mucosal ulceration 13.89 9.78 22 235700 1851 79506815
Scopulariopsis infection 13.86 9.78 7 235715 120 79508546
Cutaneous T-cell lymphoma stage I 13.84 9.78 5 235717 35 79508631
Anaphylactic shock 13.83 9.78 57 235665 35939 79472727
Panic attack 13.82 9.78 32 235690 24184 79484482
Hodgkin's disease mixed cellularity stage unspecified 13.80 9.78 4 235718 12 79508654
Transitional cell carcinoma 13.80 9.78 26 235696 2515 79506151
Laryngeal mass 13.79 9.78 6 235716 72 79508594
Cutaneous symptom 13.77 9.78 12 235710 530 79508136
Pain of skin 13.76 9.78 82 235640 14531 79494135
Swelling of eyelid 13.73 9.78 33 235689 3778 79504888
Sebaceous adenoma 13.72 9.78 5 235717 36 79508630
Subacute sclerosing panencephalitis 13.72 9.78 5 235717 36 79508630
Chorioretinal folds 13.72 9.78 5 235717 36 79508630
Incoherent 13.66 9.78 3 235719 7689 79500977
Rhabdomyosarcoma recurrent 13.65 9.78 7 235715 124 79508542
Bone marrow myelogram abnormal 13.64 9.78 6 235716 74 79508592
Respiratory rate increased 13.61 9.78 27 235695 21573 79487093
Chronic hepatitis 13.61 9.78 19 235703 1428 79507238
Hypersomnia 13.59 9.78 30 235692 23056 79485610
Telangiectasia 13.59 9.78 19 235703 1430 79507236
Aspergillus test positive 13.59 9.78 14 235708 764 79507902
Hepatitis C virus test 13.57 9.78 6 235716 75 79508591
Upper respiratory tract inflammation 13.54 9.78 34 235688 4001 79504665
Pulmonary arterial hypertension 13.52 9.78 41 235681 28325 79480341
Coccidioidomycosis 13.51 9.78 18 235704 1294 79507372
Central obesity 13.50 9.78 21 235701 1740 79506926
Abscess fungal 13.47 9.78 10 235712 350 79508316
Adjustment disorder with depressed mood 13.45 9.78 5 235717 9081 79499585
Pulmonary hypertension 13.44 9.78 85 235637 47995 79460671
Toothache 13.43 9.78 24 235698 19946 79488720
Endoscopic retrograde cholangiopancreatography 13.43 9.78 6 235716 77 79508589
Hydronephrosis 13.39 9.78 93 235629 17361 79491305
Tonsillitis 13.37 9.78 47 235675 6667 79501999
Speech disorder 13.36 9.78 100 235622 54345 79454321
Cardiac valve vegetation 13.35 9.78 15 235707 904 79507762
Splenectomy 13.34 9.78 14 235708 781 79507885
Metabolic acidosis 13.30 9.78 168 235554 82361 79426305
Cardiac failure 13.30 9.78 352 235370 154490 79354176
Hypomania 13.28 9.78 3 235719 7541 79501125
Karyotype analysis abnormal 13.27 9.78 5 235717 40 79508626
Blood phosphorus increased 13.26 9.78 7 235715 10340 79498326
Central nervous system lesion 13.23 9.78 76 235646 13292 79495374
Grip strength decreased 13.22 9.78 28 235694 21841 79486825
Rectosigmoid cancer 13.22 9.78 9 235713 274 79508392
Subdural haematoma 13.22 9.78 48 235674 31386 79477280
Hospice care 13.21 9.78 7 235715 10317 79498349
Thymoma 13.19 9.78 9 235713 275 79508391
Acid base balance abnormal 13.18 9.78 10 235712 362 79508304
Pulmonary thrombosis 13.18 9.78 10 235712 12161 79496505
Fungal abscess central nervous system 13.16 9.78 7 235715 134 79508532
Osteolysis 13.16 9.78 36 235686 4462 79504204
Alexia 13.12 9.78 4 235718 15 79508651
Diffuse large B-cell lymphoma stage I 13.12 9.78 4 235718 15 79508651
Urinary bladder haematoma 13.12 9.78 4 235718 15 79508651
Metastases to salivary gland 13.12 9.78 4 235718 15 79508651
Oral papilloma 13.12 9.78 4 235718 15 79508651
Hallucination, visual 13.10 9.78 51 235671 32678 79475988
Cerebrovascular insufficiency 13.07 9.78 7 235715 136 79508530
Retinal pigment epitheliopathy 13.07 9.78 11 235711 463 79508203
Biopsy muscle abnormal 13.06 9.78 5 235717 42 79508624
Gastroenteritis salmonella 13.05 9.78 16 235706 1058 79507608
Disseminated cytomegaloviral infection 13.05 9.78 11 235711 464 79508202
Pyelonephritis 13.02 9.78 104 235618 20284 79488382
Sputum discoloured 13.01 9.78 28 235694 21715 79486951
Pyelonephritis chronic 12.99 9.78 9 235713 282 79508384
Nosocomial infection 12.99 9.78 27 235695 2805 79505861
Blood loss anaemia 12.98 9.78 16 235706 15482 79493184
Dementia 12.97 9.78 34 235688 24625 79484041
Transfusion-related acute lung injury 12.96 9.78 9 235713 283 79508383
Extrasystoles 12.96 9.78 3 235719 7416 79501250
Agranulocytosis 12.96 9.78 196 235526 44834 79463832
Renal atrophy 12.94 9.78 21 235701 1804 79506862
Ureteral neoplasm 12.92 9.78 4 235718 16 79508650
Hot flush 12.90 9.78 102 235620 54775 79453891
Anhedonia 12.89 9.78 15 235707 14883 79493783
Aspiration 12.88 9.78 25 235697 20133 79488533
Ventricular arrhythmia 12.86 9.78 5 235717 8835 79499831
Toxoplasma serology positive 12.85 9.78 5 235717 44 79508622
Superficial spreading melanoma stage unspecified 12.80 9.78 9 235713 289 79508377
Lymphoma 12.80 9.78 92 235630 17368 79491298
Metastatic malignant melanoma 12.79 9.78 27 235695 2836 79505830
Nervousness 12.78 9.78 53 235669 33362 79475304
Photodermatosis 12.76 9.78 15 235707 949 79507717
Refractoriness to platelet transfusion 12.76 9.78 7 235715 143 79508523
Sleep disorder due to a general medical condition 12.76 9.78 14 235708 14263 79494403
Renal cell carcinoma stage I 12.76 9.78 5 235717 45 79508621
Mycobacterium fortuitum infection 12.73 9.78 8 235714 212 79508454
Vaccination failure 12.70 9.78 21 235701 1832 79506834
B-cell aplasia 12.70 9.78 8 235714 213 79508453
Citrobacter infection 12.69 9.78 15 235707 955 79507711
Retching 12.67 9.78 20 235702 17447 79491219
Pigmentation disorder 12.66 9.78 41 235681 5577 79503089
Polyomavirus test positive 12.66 9.78 8 235714 214 79508452
T-cell prolymphocytic leukaemia 12.66 9.78 5 235717 46 79508620
Cranial nerve disorder 12.63 9.78 16 235706 1094 79507572
Malignant melanoma stage I 12.63 9.78 7 235715 146 79508520
Needle issue 12.60 9.78 12 235710 13056 79495610
Hypocomplementaemia 12.60 9.78 8 235714 216 79508450
BK polyomavirus test positive 12.59 9.78 7 235715 147 79508519
Device breakage 12.58 9.78 8 235714 10667 79497999
Adjusted calcium decreased 12.56 9.78 8 235714 217 79508449
Magnetic resonance imaging head abnormal 12.52 9.78 26 235696 2700 79505966
Affect lability 12.51 9.78 9 235713 11250 79497416
Pneumonia pneumococcal 12.50 9.78 33 235689 4004 79504662
Retinal infiltrates 12.47 9.78 5 235717 48 79508618
Osteoporotic fracture 12.47 9.78 34 235688 4206 79504460
Nasal septum disorder 12.46 9.78 7 235715 150 79508516
Kidney enlargement 12.42 9.78 17 235705 1254 79507412
Hyperchromasia 12.41 9.78 3 235719 3 79508663
Leukaemic infiltration hepatic 12.41 9.78 3 235719 3 79508663
Peripheral artery dissection 12.41 9.78 3 235719 3 79508663
Lymphocele marsupialisation 12.41 9.78 3 235719 3 79508663
Nail pterygium 12.41 9.78 3 235719 3 79508663
Bence Jones protein urine present 12.41 9.78 3 235719 3 79508663
Large cell lung cancer stage IV 12.41 9.78 3 235719 3 79508663
Stent removal 12.41 9.78 3 235719 3 79508663
Cardiopulmonary bypass 12.41 9.78 3 235719 3 79508663
Coxsackie virus test positive 12.41 9.78 3 235719 3 79508663
Transfusion associated graft versus host disease 12.41 9.78 3 235719 3 79508663
Platelet destruction increased 12.41 9.78 3 235719 3 79508663
Ileal ulcer 12.41 9.78 16 235706 1114 79507552
Gammopathy 12.40 9.78 8 235714 222 79508444
Cold agglutinins positive 12.38 9.78 5 235717 49 79508617
Hypertrophy of tongue papillae 12.38 9.78 5 235717 49 79508617
Prostatic abscess 12.36 9.78 10 235712 398 79508268
Cryptosporidiosis infection 12.31 9.78 13 235709 730 79507936
Splenic artery aneurysm 12.30 9.78 6 235716 95 79508571
Amyloidosis senile 12.29 9.78 5 235717 50 79508616
Acute generalised exanthematous pustulosis 12.28 9.78 20 235702 17234 79491432
Spindle cell sarcoma 12.28 9.78 8 235714 226 79508440
Pathological fracture 12.27 9.78 8 235714 10529 79498137
Appendicitis 12.26 9.78 27 235695 20767 79487899
Musculoskeletal stiffness 12.25 9.78 409 235313 174599 79334067
Cord blood transplant therapy 12.21 9.78 5 235717 51 79508615
Progressive bulbar palsy 12.20 9.78 4 235718 20 79508646
Macule 12.19 9.78 27 235695 2930 79505736
Neutrophil morphology abnormal 12.19 9.78 6 235716 97 79508569
Renal haemorrhage 12.15 9.78 23 235699 2233 79506433
Lip swelling 12.13 9.78 71 235651 40840 79467826
Haematoma evacuation 12.12 9.78 9 235713 315 79508351
Embolic stroke 12.11 9.78 4 235718 7822 79500844
Lipohypertrophy 12.11 9.78 14 235708 870 79507796
Injection site urticaria 12.11 9.78 12 235710 12814 79495852
Conjunctival oedema 12.10 9.78 16 235706 1142 79507524
Anti-platelet antibody positive 12.07 9.78 9 235713 317 79508349
Herpes zoster meningoencephalitis 12.06 9.78 13 235709 748 79507918
Cerebrosclerosis 12.04 9.78 4 235718 21 79508645
Nephroblastoma 12.04 9.78 4 235718 21 79508645
Bone density decreased 12.02 9.78 13 235709 13334 79495332
Product dose omission in error 12.02 9.78 4 235718 7784 79500882
Actinomycotic sepsis 11.97 9.78 6 235716 101 79508565
Hepatitis C antibody positive 11.97 9.78 8 235714 236 79508430
Polycythaemia 11.94 9.78 23 235699 2261 79506405
Reticulocytopenia 11.94 9.78 8 235714 237 79508429
Pneumonia lipoid 11.94 9.78 7 235715 163 79508503
Parosmia 11.93 9.78 3 235719 7011 79501655
Pseudallescheria infection 11.89 9.78 4 235718 22 79508644
Extra dose administered 11.85 9.78 5 235717 8410 79500256
Osteoarthritis 11.84 9.78 184 235538 87125 79421541
Atelectasis 11.83 9.78 52 235670 32205 79476461
Urinary tract infection pseudomonal 11.82 9.78 20 235702 1778 79506888
Anal fissure 11.81 9.78 4 235718 7699 79500967
Palmar-plantar erythrodysaesthesia syndrome 11.80 9.78 54 235668 33080 79475586
Ischaemic stroke 11.79 9.78 54 235668 33077 79475589
Accidental exposure to product 11.79 9.78 50 235672 31272 79477394
Eructation 11.76 9.78 9 235713 10900 79497766
Cholestasis 11.76 9.78 218 235504 51891 79456775
Orchitis 11.72 9.78 17 235705 1324 79507342
Acid fast bacilli infection 11.72 9.78 7 235715 169 79508497
Meningoradiculitis 11.68 9.78 7 235715 170 79508496
Evans syndrome 11.68 9.78 10 235712 431 79508235
Autoimmune hepatitis 11.66 9.78 67 235655 11716 79496950
Pulmonary cavitation 11.66 9.78 19 235703 1637 79507029
Gingival swelling 11.65 9.78 35 235687 4574 79504092
Delusion 11.65 9.78 27 235695 20396 79488270
Haemoglobinuria 11.64 9.78 13 235709 778 79507888
Multiple use of single-use product 11.61 9.78 14 235708 910 79507756
Hepatitis B surface antigen positive 11.61 9.78 7 235715 172 79508494
Pseudolymphoma 11.60 9.78 16 235706 1189 79507477
Squamous cell carcinoma of the cervix 11.59 9.78 8 235714 249 79508417
Herpes ophthalmic 11.59 9.78 18 235704 1489 79507177
Oesophageal candidiasis 11.59 9.78 56 235666 9162 79499504
Muscle rigidity 11.57 9.78 26 235696 19856 79488810
Botryomycosis 11.56 9.78 5 235717 59 79508607
Bacterial abdominal infection 11.55 9.78 3 235719 5 79508661
Polymorphonuclear chromatin clumping 11.55 9.78 3 235719 5 79508661
Neurological symptom 11.51 9.78 54 235668 8729 79499937
Retinal detachment 11.50 9.78 56 235666 9191 79499475
Breast pain 11.50 9.78 5 235717 8260 79500406
Corneal graft rejection 11.49 9.78 5 235717 60 79508606
Dysphonia 11.46 9.78 110 235612 56762 79451904
Biliary anastomosis complication 11.46 9.78 7 235715 176 79508490
Mycobacterium abscessus infection 11.43 9.78 16 235706 1206 79507460
Pneumonia staphylococcal 11.38 9.78 36 235686 4838 79503828
Eyelid pain 11.32 9.78 9 235713 349 79508317
Cutaneous lymphoma 11.29 9.78 8 235714 260 79508406
Hallucination, auditory 11.29 9.78 28 235694 20665 79488001
Bronchostenosis 11.29 9.78 12 235710 679 79507987
Stenotrophomonas sepsis 11.29 9.78 7 235715 181 79508485
Hypophagia 11.29 9.78 83 235639 45284 79463382
Product administration error 11.28 9.78 52 235670 31794 79476872
Onychalgia 11.28 9.78 14 235708 938 79507728
Hepatic cirrhosis 11.26 9.78 155 235567 34751 79473915
Finger deformity 11.26 9.78 4 235718 7470 79501196
Cytomegalovirus gastroenteritis 11.24 9.78 10 235712 454 79508212
Thoracotomy 11.23 9.78 6 235716 116 79508550
Eosinophilic pustular folliculitis 11.23 9.78 6 235716 116 79508550
Refractory cytopenia with multilineage dysplasia 11.21 9.78 8 235714 263 79508403
Lymphocyte morphology abnormal 11.21 9.78 14 235708 944 79507722
Skin cancer metastatic 11.20 9.78 3 235719 6 79508660
Instillation site dryness 11.20 9.78 3 235719 6 79508660
Nonkeratinising carcinoma of nasopharynx 11.20 9.78 3 235719 6 79508660
Blood gonadotrophin increased 11.20 9.78 3 235719 6 79508660
Transfusion microchimerism 11.20 9.78 3 235719 6 79508660
Delayed graft function 11.20 9.78 29 235693 3478 79505188
Myocarditis toxoplasmal 11.20 9.78 5 235717 64 79508602
Inappropriate antidiuretic hormone secretion 11.18 9.78 40 235682 26273 79482393
Ear infection 11.17 9.78 58 235664 34374 79474292
Skin hyperpigmentation 11.16 9.78 47 235675 7256 79501410
Cutaneous malacoplakia 11.14 9.78 6 235716 118 79508548
Sebaceous carcinoma 11.14 9.78 6 235716 118 79508548
Intravascular haemolysis 11.13 9.78 13 235709 817 79507849
Nasopharyngeal cancer 11.12 9.78 7 235715 186 79508480
Carotid artery stenosis 11.12 9.78 6 235716 8752 79499914
Diffuse axonal injury 11.09 9.78 6 235716 119 79508547
Acquired gene mutation 11.09 9.78 22 235700 2211 79506455
Acute leukaemia 11.08 9.78 19 235703 1707 79506959
Acute myeloid leukaemia (in remission) 11.07 9.78 4 235718 28 79508638
Skin infection 11.07 9.78 92 235630 18153 79490513
Bilirubin conjugated abnormal 11.05 9.78 6 235716 120 79508546
Laryngitis 11.04 9.78 19 235703 16020 79492646
Pseudomembranous colitis 11.03 9.78 38 235684 5336 79503330
Feeling jittery 11.03 9.78 13 235709 12828 79495838
Necrotising herpetic retinopathy 11.00 9.78 6 235716 121 79508545
Herpes simplex reactivation 10.96 9.78 10 235712 469 79508197
Neuralgia 10.96 9.78 56 235666 33328 79475338
Product complaint 10.95 9.78 14 235708 13335 79495331
Peripheral vascular disorder 10.95 9.78 5 235717 8025 79500641
Mucocutaneous leishmaniasis 10.95 9.78 10 235712 470 79508196
Aeromonas infection 10.94 9.78 9 235713 367 79508299
Haematoma 10.93 9.78 100 235622 52095 79456571
Complement factor C3 decreased 10.89 9.78 9 235713 369 79508297
Biliary anastomosis 10.89 9.78 3 235719 7 79508659
Skin hypopigmentation 10.79 9.78 14 235708 981 79507685
Breast cancer metastatic 10.76 9.78 6 235716 8596 79500070
Gamma-glutamyltransferase increased 10.74 9.78 224 235498 54456 79454210
Metastases to central nervous system 10.73 9.78 20 235702 16355 79492311
Spermatozoa progressive motility abnormal 10.72 9.78 4 235718 31 79508635
Infective chondritis 10.72 9.78 4 235718 31 79508635
Tenderness 10.71 9.78 112 235610 23530 79485136
Flank pain 10.71 9.78 27 235695 19817 79488849
Exostosis 10.69 9.78 21 235701 16837 79491829
Malignant fibrous histiocytoma 10.67 9.78 7 235715 200 79508466
Streptococcal infection 10.64 9.78 53 235669 8777 79499889
Femoral artery aneurysm 10.64 9.78 7 235715 201 79508465
Metapneumovirus infection 10.63 9.78 19 235703 1765 79506901
Tension headache 10.62 9.78 4 235718 7207 79501459
Dialysis 10.62 9.78 92 235630 18370 79490296
Miosis 10.60 9.78 19 235703 15770 79492896
Parakeratosis 10.57 9.78 9 235713 385 79508281
Orbital apex syndrome 10.55 9.78 5 235717 74 79508592
Hyperkinetic heart syndrome 10.54 9.78 6 235716 132 79508534
Osteomyelitis fungal 10.53 9.78 8 235714 290 79508376
Nasal ulcer 10.52 9.78 21 235701 2119 79506547
Wound dehiscence 10.51 9.78 43 235679 6552 79502114
Renal hypertension 10.49 9.78 7 235715 206 79508460
Hepatorenal syndrome 10.49 9.78 32 235690 4217 79504449
Metastases to bone 10.47 9.78 37 235685 24390 79484276
Palatal ulcer 10.46 9.78 6 235716 134 79508532
Rheumatoid arthritis 10.45 9.78 733 234989 207737 79300929
Arterial occlusive disease 10.44 9.78 6 235716 8450 79500216
Hydrocephalus 10.43 9.78 53 235669 8847 79499819
Neuroblastoma recurrent 10.43 9.78 7 235715 208 79508458
Dry skin 10.37 9.78 140 235582 67855 79440811
Acute promyelocytic leukaemia 10.36 9.78 17 235705 1474 79507192
Coccidioides encephalitis 10.35 9.78 3 235719 9 79508657
Vascular graft infection 10.35 9.78 3 235719 9 79508657
Renal artery stenosis 10.32 9.78 28 235694 3454 79505212
Product administered to patient of inappropriate age 10.31 9.78 38 235684 5515 79503151
Cholangitis chronic 10.30 9.78 4 235718 35 79508631
Corneal scar 10.30 9.78 8 235714 300 79508366
Activated partial thromboplastin time shortened 10.30 9.78 13 235709 886 79507780
Lipids increased 10.22 9.78 18 235704 1653 79507013
Gastric haemorrhage 10.20 9.78 18 235704 15032 79493634
Ocular vascular disorder 10.20 9.78 10 235712 514 79508152
Device related sepsis 10.20 9.78 41 235681 6199 79502467
Spinal fracture 10.19 9.78 24 235698 18030 79490636
Meningoencephalitis amoebic 10.19 9.78 6 235716 141 79508525
Human anaplasmosis 10.15 9.78 5 235717 81 79508585
Abdominal wall abscess 10.15 9.78 15 235707 1188 79507478
Photophobia 10.14 9.78 99 235623 20429 79488237
Angina unstable 10.13 9.78 21 235701 16506 79492160
Kidney anastomosis 10.11 9.78 3 235719 10 79508656
Urethral dilatation 10.11 9.78 3 235719 10 79508656
Thyroglossal cyst infection 10.11 9.78 4 235718 37 79508629
Pulmonary necrosis 10.10 9.78 10 235712 520 79508146
Acute lymphocytic leukaemia 10.08 9.78 35 235687 4934 79503732
Urine odour abnormal 10.08 9.78 3 235719 6270 79502396
Lung neoplasm malignant 10.07 9.78 45 235677 27747 79480919
Paranoia 10.06 9.78 27 235695 19405 79489261
Abscess drainage 10.06 9.78 11 235711 643 79508023
Granulomatous dermatitis 10.05 9.78 9 235713 412 79508254
Tanning 10.04 9.78 5 235717 83 79508583
Urinoma 10.03 9.78 7 235715 222 79508444
Ciliary body disorder 10.01 9.78 4 235718 38 79508628
Chest wall abscess 10.00 9.78 7 235715 223 79508443
Fungal pharyngitis 10.00 9.78 7 235715 223 79508443
Eyelid exfoliation 10 9.78 6 235716 146 79508520
Burning sensation 9.96 9.78 118 235604 58514 79450152
Bronchopneumopathy 9.94 9.78 12 235710 781 79507885
Segmented hyalinising vasculitis 9.93 9.78 5 235717 85 79508581
Rhinitis allergic 9.93 9.78 13 235709 12256 79496410
Cytopenia 9.93 9.78 98 235624 20285 79488381
Cutaneous tuberculosis 9.92 9.78 7 235715 226 79508440
Vitrectomy 9.92 9.78 7 235715 226 79508440
Parainfluenzae viral bronchitis 9.89 9.78 3 235719 11 79508655
Hepatic artery thrombosis 9.87 9.78 8 235714 319 79508347
Hyperaesthesia 9.84 9.78 13 235709 12209 79496457
Encephalopathy 9.84 9.78 265 235457 67132 79441534
Lymphadenopathy mediastinal 9.83 9.78 32 235690 4364 79504302
Noninfective conjunctivitis 9.83 9.78 4 235718 40 79508626
Cystostomy 9.83 9.78 5 235717 87 79508579
Human T-cell lymphotropic virus type I infection 9.83 9.78 5 235717 87 79508579
Neutropenic infection 9.83 9.78 22 235700 2405 79506261
Nerve injury 9.81 9.78 8 235714 9384 79499282
Gastrointestinal oedema 9.79 9.78 23 235699 2595 79506071
Melaena 9.79 9.78 124 235598 60766 79447900
Hepatitis infectious mononucleosis 9.79 9.78 6 235716 152 79508514

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AD01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Calcineurin inhibitors
ATC S01XA18 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA EPC N0000175457 Calcineurin Inhibitor Immunosuppressant
FDA MoA N0000175458 Calcineurin Inhibitors
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:35718 antifungal agents
CHEBI has role CHEBI:35842 anti-rheumatic drugs
CHEBI has role CHEBI:37153 protein serine/threonine phosphatase inhibitors
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:50177 dermatologic agent
CHEBI has role CHEBI:50903 carcinogen
CHEBI has role CHEBI:149553 anticoronaviral drug
CHEBI has role CHEBI:176497 geroprotectors
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
FDA MoA N0000185503 P-Glycoprotein Inhibitors
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D065095 Calcineurin Inhibitors
MeSH PA D003879 Dermatologic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tear film insufficiency indication 46152009
Rheumatoid arthritis indication 69896004 DOID:7148
Kawasaki's disease indication 75053002 DOID:13378
Keratoconjunctivitis sicca indication 302896008 DOID:12895
Prevention of Liver Transplant Rejection indication
Prevention of Cardiac Transplant Rejection indication
Prevention of Kidney Transplant Rejection indication
Severe Recalcitrant Psoriasis indication
Graft-versus-host disease off-label use 234646005
Pure Red Cell Aplasia associated with Chronic Lymphocytic Leukemia off-label use
Prevention of Lung Transplant Rejection off-label use
Prevention of Graft Versus Host Disease off-label use
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Hyperbilirubinemia contraindication 14783006 DOID:2741
Metabolic acidosis, normal anion gap, acidifying salts contraindication 18104000
Hyperuricemia contraindication 35885006 DOID:1920
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Benign intracranial hypertension contraindication 68267002 DOID:11459
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Disorder of brain contraindication 81308009 DOID:936
Kidney disease contraindication 90708001 DOID:557
Neoplasm contraindication 108369006
Malignant lymphoma contraindication 118600007 DOID:0060058
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Toxic nephropathy contraindication 236514003
Hypertriglyceridemia contraindication 302870006
Primary malignant neoplasm contraindication 372087000
Breastfeeding (mother) contraindication 413712001
Hypertensive urgency contraindication 443482000
BK Polyomavirus Reactivation Nephropathy contraindication
Cyclosporine Toxicity contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Allergic dermatitis as manifested by excoriations (including facial and neck), miliary dermatitis, eosinophilic plaques, and self-induced alopecia Indication
Dogs Chronic keratoconjunctivitis sicca (KCS) Indication
Dogs Chronic superficial keratitis (CSK) Indication
Dogs Pruritus associated with allergic dermatitis Indication
Dogs Atopic dermatitis Indication

🐶 Veterinary products

ProductApplicantIngredients
Atopica for Cats Elanco US Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.05% RESTASIS MULTIDOSE ABBVIE N050790 Oct. 27, 2016 RX EMULSION OPHTHALMIC 8633162 Aug. 27, 2024 INCREASE TEAR PRODUCTION TO TREAT PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.05% RESTASIS MULTIDOSE ABBVIE N050790 Oct. 27, 2016 RX EMULSION OPHTHALMIC 8648048 Aug. 27, 2024 INCREASE TEAR PRODUCTION IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.05% RESTASIS MULTIDOSE ABBVIE N050790 Oct. 27, 2016 RX EMULSION OPHTHALMIC 9248191 Aug. 27, 2024 INCREASE TEAR PRODUCTION TO TREAT PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.1% VERKAZIA SANTEN N214965 June 23, 2021 RX EMULSION OPHTHALMIC 11612658 Jan. 27, 2026 FOR THE TREATMENT OF VERNAL KERATOCONJUNCTIVITIS IN CHILDREN AND ADULTS
0.09% CEQUA SUN PHARM N210913 Aug. 14, 2018 RX SOLUTION OPHTHALMIC 8980839 Aug. 23, 2033 INCREASE TEAR PRODUCTION IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.09% CEQUA SUN PHARM N210913 Aug. 14, 2018 RX SOLUTION OPHTHALMIC 9937225 Aug. 23, 2033 INCREASE TEAR PRODUCTION IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.1% VEVYE NOVALIQ GMBH N217469 May 30, 2023 RX SOLUTION OPHTHALMIC 11154513 Nov. 20, 2038 TREATMENT OF THE SIGNS AND SYMPTOMS OF DRY EYE DISEASE (DED)
0.1% VEVYE NOVALIQ GMBH N217469 May 30, 2023 RX SOLUTION OPHTHALMIC 11413323 Oct. 11, 2039 TREATMENT OF DRY EYE DISEASE (DED)

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
0.1% VERKAZIA SANTEN N214965 June 23, 2021 RX EMULSION OPHTHALMIC June 23, 2024 NEW PRODUCT
0.1% VEVYE NOVALIQ GMBH N217469 May 30, 2023 RX SOLUTION OPHTHALMIC May 30, 2026 NEW PRODUCT
0.1% VERKAZIA SANTEN N214965 June 23, 2021 RX EMULSION OPHTHALMIC June 23, 2028 FOR THE TREATMENT OF VERNAL KERATOCONJUNCTIVITIS (VKC) IN CHILDREN AND ADULTS

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Peptidyl-prolyl cis-trans isomerase A Enzyme MODULATOR IC50 8.05 WOMBAT-PK CHEMBL
Multidrug resistance protein 1 Transporter EC50 6.30 WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter IC50 4.87 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP1A Enzyme IC50 7.80 WOMBAT-PK
Dihydroorotate dehydrogenase (quinone), mitochondrial Enzyme IC50 6.70 WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter IC50 5.57 CHEMBL
ATP-binding cassette sub-family G member 2 Transporter IC50 4.20 CHEMBL
Canalicular multispecific organic anion transporter 2 Transporter IC50 6.20 CHEMBL
fMet-Leu-Phe receptor GPCR ANTAGONIST EC50 6.30 IUPHAR
Bile salt export pump Transporter IC50 6.30 CHEMBL
Solute carrier organic anion transporter family member 1B1 Transporter INHIBITOR Ki 7.29 IUPHAR
Peptidyl-prolyl cis-trans isomerase FKBP4 Enzyme IC50 7.80 CHEMBL
Substance-K receptor GPCR Ki 5.86 DRUG MATRIX
Peptidyl-prolyl cis-trans isomerase B Enzyme Kd 8.01 CHEMBL
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Enzyme Kd 8.40 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP1B Enzyme Ki 8.22 CHEMBL
Peptidyl-prolyl cis-trans isomerase D Enzyme Ki 8.15 CHEMBL
Solute carrier organic anion transporter family member 1B3 Transporter INHIBITOR IC50 6.10 IUPHAR
Sodium/bile acid cotransporter Transporter INHIBITOR IC50 6 IUPHAR
Cytochrome P450 3A4 Enzyme Ki 5.31 WOMBAT-PK
Calcineurin subunit B type 1 Unclassified IC50 4.47 CHEMBL
Reverse transcriptase/RNaseH Enzyme IC50 6.34 CHEMBL
Bile salt export pump Transporter IC50 6.22 CHEMBL
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Kinase IC50 6.24 CHEMBL
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Enzyme IC50 4.21 CHEMBL

External reference:

IDSource
4018761 VUID
N0000147064 NUI
D00184 KEGG_DRUG
63798-73-2 SECONDARY_CAS_RN
202817 RXNORM
4018761 VANDF
C0010592 UMLSCUI
CHEBI:4031 CHEBI
CHEMBL160 ChEMBL_ID
5284373 PUBCHEM_CID
DB00091 DRUGBANK_ID
3027 MMSL
31626 MMSL
4521 MMSL
72396 MMSL
d00079 MMSL
003420 NDDF
387467008 SNOMEDCT_US
80906007 SNOMEDCT_US
D016572 MESH_DESCRIPTOR_UI
5086 INN_ID
1024 IUPHAR_LIGAND_ID
26496N541O UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Restasis MultiDose HUMAN PRESCRIPTION DRUG LABEL 1 0023-5301 EMULSION 0.50 mg OPHTHALMIC NDA 24 sections
Restasis MultiDose HUMAN PRESCRIPTION DRUG LABEL 1 0023-5301 EMULSION 0.50 mg OPHTHALMIC NDA 24 sections
Restasis MultiDose HUMAN PRESCRIPTION DRUG LABEL 1 0023-5301 EMULSION 0.50 mg OPHTHALMIC NDA 24 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 0023-9163 EMULSION 0.50 mg OPHTHALMIC NDA 24 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 0023-9163 EMULSION 0.50 mg OPHTHALMIC NDA 24 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-0541 CAPSULE 50 mg ORAL ANDA 26 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-0541 CAPSULE 50 mg ORAL ANDA 26 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-3108 CAPSULE 25 mg ORAL ANDA 26 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-3108 CAPSULE 25 mg ORAL ANDA 26 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-3109 CAPSULE 100 mg ORAL ANDA 26 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-3109 CAPSULE 100 mg ORAL ANDA 26 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-6463 CAPSULE 25 mg ORAL ANDA 26 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-6463 CAPSULE 25 mg ORAL ANDA 26 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-6479 CAPSULE 100 mg ORAL ANDA 26 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-6479 CAPSULE 100 mg ORAL ANDA 26 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-7269 SOLUTION 100 mg ORAL ANDA 25 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-7269 SOLUTION 100 mg ORAL ANDA 25 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0109 INJECTION 50 mg INTRAVENOUS NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0109 INJECTION 50 mg INTRAVENOUS NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0109 INJECTION 50 mg INTRAVENOUS NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0110 SOLUTION 100 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0110 SOLUTION 100 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0110 SOLUTION 100 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0240 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0240 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0240 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0241 CAPSULE, LIQUID FILLED 100 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0241 CAPSULE, LIQUID FILLED 100 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0241 CAPSULE, LIQUID FILLED 100 mg ORAL NDA 23 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0246 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 23 sections