ciclosporin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
ciclosporin derivatives 760 59865-13-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • neoral
  • ciclosporin
  • cyclosporine
  • cyclosporin
  • ciclosporine
  • cyclosporin A
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
  • Molecular weight: 1202.64
  • Formula: C62H111N11O12
  • CLOGP: 12
  • LIPINSKI: 3
  • HAC: 23
  • HDO: 5
  • TPSA: 278.80
  • ALOGS: -5.10
  • ROTB: 15
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.25 g O
0.25 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0.10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.66 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 27 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.07 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.30 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 4.101 Moderate 0.79
caco2-efflux Caco-2 efflux ratio (BA/AB) 27.353 Moderate 0.79
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 6.855 10^-6 cm/s Moderate 0.79
dh-clint Dog hepatocyte intrinsic clearance 45.920 uL/min/10^6 cells Moderate 0.79
dppb Dog plasma protein binding (% unbound) 1.730 % Moderate 0.79
fcs-ppb Fetal calf serum protein binding (% unbound) 3.610 % Moderate 0.79
herg hERG pIC50 4.220 pIC50 Moderate 0.79
hh-clint Human hepatocyte intrinsic clearance 3.656 uL/min/10^6 cells Moderate 0.79
hlm-clint Human liver microsomal intrinsic clearance 17.620 uL/min/mg protein Moderate 0.79
hppb Human plasma protein binding (% unbound) 3.570 % Moderate 0.79
kinase-safety-class CDK5,EIF2AK3,GRK2,PDK1,PDK2 5
kinase-selectivity-class PDK1 1
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 47.206 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 26.607 Moderate 0.79
mh-clint Mouse hepatocyte intrinsic clearance 7.568 Moderate 0.79
mppb Mouse plasma protein binding (% unbound) 0.950 Moderate 0.79
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 211.836 Moderate 0.79
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 0.660 % Moderate 0.79
rat-kpuu-brain Rat brain Kpuu 0.006 % High 1
rh-clint Rat hepatocyte intrinsic clearance 8.730 uL/min/10^6 cells Moderate 0.79
rh-fuinc Rat hepatocyte fraction unbound in incubation 7.710 % Moderate 0.79
rppb Rat plasma protein binding (% unbound) 1.540 % Moderate 0.79
solubility-dd Solubility at pH 7.4 in DMSO 87.096 uM Moderate 0.79

Approvals:

DateAgencyCompanyOrphan
Feb. 21, 2020 PMDA Novartis Pharma K.K.
Nov. 14, 1983 FDA NOVARTIS
May 19, 2015 EMA Santen Oy

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 1879.77 9.23 984 192881 25618 90408964
Eye irritation 1678.19 9.23 993 192872 32985 90401597
Transplant dysfunction 1618.38 9.23 555 193310 4727 90429855
Transplant rejection 1554.30 9.23 686 193179 12072 90422510
Graft versus host disease 1223.43 9.23 508 193357 7636 90426946
Acute graft versus host disease 1164.63 9.23 439 193426 5029 90429553
Chronic graft versus host disease 1133.50 9.23 400 193465 3739 90430843
Acute graft versus host disease in skin 1042.62 9.23 390 193475 4366 90430216
Epstein-Barr virus infection 1001.18 9.23 474 193391 9870 90424712
Product use in unapproved indication 832.62 9.23 2061 191804 334175 90100407
Graft versus host disease in gastrointestinal tract 808.36 9.23 317 193548 4071 90430511
Post transplant lymphoproliferative disorder 796.16 9.23 358 193507 6591 90427991
Graft versus host disease in skin 790.42 9.23 301 193564 3552 90431030
Thrombotic microangiopathy 724.90 9.23 440 193425 15303 90419279
Ovarian cyst 708.69 9.23 449 193416 16869 90417713
Cytomegalovirus infection reactivation 701.86 9.23 340 193525 7460 90427122
Posterior reversible encephalopathy syndrome 701.18 9.23 491 193374 21848 90412734
Blood iron abnormal 628.29 9.23 258 193607 3762 90430820
Renal impairment 624.41 9.23 937 192928 104484 90330098
Drug ineffective 607.49 9.23 5030 188835 1379268 89055314
Adenovirus infection 557.92 9.23 247 193618 4375 90430207
BK virus infection 557.89 9.23 245 193620 4253 90430329
Kidney transplant rejection 539.84 9.23 245 193620 4612 90429970
Acne 522.83 9.23 456 193409 28051 90406531
Eye pain 513.86 9.23 550 193315 43618 90390964
Acute graft versus host disease in intestine 512.61 9.23 186 193679 1897 90432685
Multiple organ dysfunction syndrome 474.22 9.23 655 193210 67681 90366901
Haemophagocytic lymphohistiocytosis 471.70 9.23 334 193531 15125 90419457
Pemphigus 466.83 9.23 71 193794 326793 90107789
Blood parathyroid hormone decreased 441.51 9.23 293 193572 11923 90422659
Cystitis haemorrhagic 435.65 9.23 220 193645 5293 90429289
Panniculitis 426.46 9.23 306 193559 14152 90420430
Glossodynia 424.39 9.23 86 193779 321693 90112889
Cytomegalovirus viraemia 422.90 9.23 240 193625 7346 90427236
Nephropathy toxic 421.91 9.23 289 193576 12399 90422183
Off label use 415.98 9.23 3879 189986 1098373 89336209
Hand deformity 399.68 9.23 75 193790 296287 90138295
Granuloma skin 397.72 9.23 261 193604 10419 90424163
Blood creatinine increased 389.50 9.23 743 193122 100643 90333939
Foreign body sensation in eyes 387.55 9.23 173 193692 3127 90431455
Skin necrosis 381.13 9.23 305 193560 16636 90417946
Ocular hyperaemia 381.06 9.23 414 193451 33384 90401198
Drug ineffective for unapproved indication 358.83 9.23 567 193298 66077 90368505
Basal cell carcinoma 352.25 9.23 395 193470 32994 90401588
Folliculitis 329.89 9.23 29 193836 204324 90230258
Systemic lupus erythematosus 329.56 9.23 182 193683 361714 90072868
Muscle injury 328.33 9.23 11 193854 176643 90257939
Aspergillus infection 325.95 9.23 232 193633 10591 90423991
Wound 309.96 9.23 130 193735 302850 90131732
Swelling 309.50 9.23 265 193600 418793 90015789
Pericarditis 306.59 9.23 98 193767 270053 90164529
Irritable bowel syndrome 305.53 9.23 41 193824 207407 90227175
Rheumatoid nodule 302.08 9.23 288 193577 19878 90414704
Immunosuppressant drug level increased 296.28 9.23 161 193704 4519 90430063
Epstein-Barr virus associated lymphoproliferative disorder 291.56 9.23 133 193732 2534 90432048
Completed suicide 289.13 9.23 4 193861 145054 90289528
Bronchopulmonary aspergillosis 279.67 9.23 216 193649 11182 90423400
Acute graft versus host disease in liver 279.62 9.23 93 193772 713 90433869
Duodenal ulcer perforation 277.76 9.23 66 193799 221222 90213360
Epstein-Barr virus infection reactivation 269.28 9.23 109 193756 1528 90433054
Chronic graft versus host disease in skin 269.28 9.23 101 193764 1139 90433443
Skin ulcer 261.23 9.23 420 193445 49655 90384927
Anti-cyclic citrullinated peptide antibody positive 260.84 9.23 90 193775 236343 90198239
Confusional state 259.50 9.23 266 193599 385939 90048643
Helicobacter infection 257.89 9.23 82 193783 226768 90207814
Hypercalcaemia 256.92 9.23 341 193524 33899 90400683
Ulcer 253.72 9.23 332 193533 32550 90402032
Wheezing 251.87 9.23 97 193768 237983 90196599
Abdominal discomfort 250.04 9.23 397 193468 476931 89957651
Type 2 diabetes mellitus 248.50 9.23 64 193801 203180 90231402
Human herpesvirus 6 infection 239.56 9.23 126 193739 3306 90431276
Rheumatic fever 238.46 9.23 25 193840 153096 90281486
Smooth muscle cell neoplasm 238.23 9.23 95 193770 1278 90433304
Impaired healing 237.05 9.23 102 193763 234097 90200485
Discomfort 235.46 9.23 148 193717 274187 90160395
Graft versus host disease in liver 233.27 9.23 85 193780 878 90433704
Venoocclusive liver disease 226.91 9.23 148 193717 5845 90428737
Lower respiratory tract infection 225.27 9.23 128 193737 250531 90184051
Viral haemorrhagic cystitis 223.76 9.23 93 193772 1400 90433182
Drug eruption 222.81 9.23 324 193541 35083 90399499
Pseudomonas infection 222.09 9.23 212 193653 14653 90419929
Instillation site pain 217.54 9.23 80 193785 850 90433732
Demyelination 214.57 9.23 161 193704 7979 90426603
Gingival hypertrophy 210.36 9.23 100 193765 2100 90432482
Dyspnoea 206.06 9.23 1078 192787 879877 89554705
Dizziness 204.54 9.23 616 193249 588668 89845914
Injury 204.45 9.23 83 193782 197266 90237316
Liver transplant rejection 201.04 9.23 90 193775 1638 90432944
Fatigue 200.85 9.23 1547 192318 1152476 89282106
Disease recurrence 199.38 9.23 318 193547 37335 90397247
Product container issue 199.01 9.23 96 193769 2085 90432497
Fall 194.79 9.23 467 193398 481343 89953239
Viraemia 194.40 9.23 87 193778 1582 90433000
Bursitis 193.85 9.23 26 193839 131628 90302954
Hypogammaglobulinaemia 192.17 9.23 169 193696 10505 90424077
Swollen joint count increased 190.17 9.23 12 193853 111194 90323388
Liver function test abnormal 187.06 9.23 366 193499 50479 90384103
Sepsis 185.86 9.23 820 193045 178994 90255588
Cytomegalovirus test positive 185.19 9.23 108 193757 3483 90431099
Scleral hyperaemia 183.24 9.23 54 193811 262 90434320
Complications of transplanted kidney 182.16 9.23 99 193766 2779 90431803
Therapeutic response decreased 181.57 9.23 511 193354 89218 90345364
Lacrimation increased 178.13 9.23 253 193612 26809 90407773
Cytomegalovirus colitis 177.70 9.23 103 193762 3283 90431299
Treatment failure 175.45 9.23 1182 192683 302746 90131836
Facet joint syndrome 173.20 9.23 9 193856 98380 90336202
Hypoaesthesia 172.39 9.23 253 193612 313957 90120625
Alanine aminotransferase increased 171.24 9.23 600 193265 117738 90316844
Obliterative bronchiolitis 169.07 9.23 92 193773 2589 90431993
SLE arthritis 168.91 9.23 62 193803 655 90433927
Blister 168.48 9.23 178 193687 254820 90179762
Weight increased 166.56 9.23 408 193457 417519 90017063
Intentional overdose 163.88 9.23 9 193856 93825 90340757
Drug resistance 161.00 9.23 257 193608 30192 90404390
Epstein-Barr viraemia 159.73 9.23 73 193792 1397 90433185
General physical health deterioration 159.19 9.23 325 193540 354790 90079792
Aspartate aminotransferase increased 158.63 9.23 533 193332 102404 90332178
Lip dry 158.42 9.23 16 193849 100939 90333643
Aplastic anaemia 157.39 9.23 167 193698 13102 90421480
Mucosal inflammation 156.82 9.23 367 193498 57258 90377324
Impaired gastric emptying 151.56 9.23 161 193704 12648 90421934
Ill-defined disorder 151.47 9.23 105 193760 184786 90249796
Abdominal pain upper 149.50 9.23 304 193561 332370 90102212
Gastrooesophageal reflux disease 149.31 9.23 85 193780 166252 90268330
Prescribed overdose 149.29 9.23 17 193848 97608 90336974
Venoocclusive disease 148.62 9.23 82 193783 2373 90432209
Asthenia 146.98 9.23 615 193250 533136 89901446
Eye discharge 145.18 9.23 129 193736 8129 90426453
Nasopharyngitis 145.10 9.23 420 193445 406684 90027898
Breast cancer stage III 144.73 9.23 9 193856 84438 90350144
Anxiety 142.68 9.23 279 193586 309493 90125089
Complications of bone marrow transplant 142.35 9.23 49 193816 422 90434160
Joint range of motion decreased 142.17 9.23 56 193809 135587 90298995
Enthesopathy 142.16 9.23 135 193730 9269 90425313
Contusion 141.99 9.23 198 193667 251018 90183564
Herpes zoster 141.37 9.23 485 193380 94159 90340423
Fibromyalgia 140.76 9.23 140 193725 206129 90228453
Pneumonia cytomegaloviral 140.75 9.23 86 193779 3025 90431557
Heart transplant rejection 138.15 9.23 56 193809 788 90433794
Pain 137.63 9.23 1416 192449 994925 89439657
Elbow deformity 136.33 9.23 66 193799 1445 90433137
Pneumocystis jirovecii pneumonia 136.28 9.23 198 193667 21418 90413164
Memory impairment 135.60 9.23 133 193732 197111 90237471
Nausea 135.60 9.23 1623 192242 1108693 89325889
Liver injury 134.32 9.23 101 193764 170466 90264116
Decreased appetite 133.78 9.23 389 193476 376151 90058431
Chronic allograft nephropathy 130.10 9.23 53 193812 756 90433826
Lung transplant rejection 130.06 9.23 57 193808 984 90433598
Alveolar proteinosis 129.37 9.23 54 193811 822 90433760
Asthma 128.89 9.23 199 193666 241961 90192621
Night sweats 128.78 9.23 57 193808 128709 90305873
Transplant failure 128.16 9.23 69 193796 1900 90432682
Herpes simplex 127.66 9.23 132 193733 10049 90424533
Renal tubular injury 126.27 9.23 59 193806 1190 90433392
Deep vein thrombosis postoperative 126.15 9.23 6 193859 70803 90363779
Varicella zoster virus infection 125.80 9.23 87 193778 3790 90430792
Vision blurred 125.51 9.23 518 193347 109775 90324807
Red blood cell sedimentation rate 124.71 9.23 93 193772 4565 90430017
Chronic graft versus host disease in liver 124.34 9.23 41 193824 305 90434277
Depression 124.02 9.23 288 193577 300313 90134269
Vomiting 123.78 9.23 1085 192780 787208 89647374
Immunosuppressant drug level decreased 123.39 9.23 57 193808 1119 90433463
Red blood cell sedimentation rate increased 122.26 9.23 422 193443 82173 90352409
Road traffic accident 122.08 9.23 39 193826 107587 90326995
Polyomavirus viraemia 120.26 9.23 58 193807 1259 90433323
Renal failure 119.45 9.23 576 193289 130431 90304151
Paraesthesia 119.15 9.23 221 193644 250105 90184477
Sleep disorder 119.12 9.23 149 193716 197881 90236701
Lymphoproliferative disorder 118.39 9.23 87 193778 4175 90430407
Constipation 117.80 9.23 266 193599 280129 90154453
Lower limb fracture 117.77 9.23 20 193845 84993 90349589
Muscle spasms 117.58 9.23 225 193640 251658 90182924
Drug abuse 117.16 9.23 18 193847 82329 90352253
Pathogen resistance 116.06 9.23 113 193752 8002 90426580
Peripheral venous disease 115.69 9.23 20 193845 83901 90350681
Hypotension 115.68 9.23 336 193529 325061 90109521
Diffuse large B-cell lymphoma 115.52 9.23 116 193749 8529 90426053
Infusion related reaction 115.40 9.23 479 193386 416301 90018281
Dyspepsia 115.17 9.23 153 193712 198007 90236575
Malaise 114.35 9.23 759 193106 585227 89849355
Leukopenia 113.81 9.23 472 193393 100238 90334344
Arthropathy 112.92 9.23 403 193462 365839 90068743
Wound infection 111.38 9.23 44 193821 106358 90328224
Dry mouth 111.21 9.23 138 193727 183921 90250661
Septic shock 110.10 9.23 413 193452 83747 90350835
Lymphocele 109.80 9.23 47 193818 764 90433818
Eye pruritus 109.25 9.23 211 193654 28816 90405766
Systemic candida 108.81 9.23 88 193777 4871 90429711
Skin plaque 108.61 9.23 120 193745 9855 90424727
Mucormycosis 108.40 9.23 79 193786 3742 90430840
Skin lesion 108.31 9.23 244 193621 37121 90397461
Proteinuria 107.57 9.23 185 193680 23106 90411476
Soft tissue disorder 106.77 9.23 82 193783 4208 90430374
Obesity 106.61 9.23 46 193819 105461 90329121
Rheumatoid factor positive 106.56 9.23 126 193739 171524 90263058
Delirium 106.25 9.23 45 193820 104314 90330268
Drug intolerance 106.17 9.23 1441 192424 446150 89988432
Tongue disorder 105.26 9.23 123 193742 10737 90423845
Hypertrichosis 105.23 9.23 55 193810 1424 90433158
Grip strength decreased 102.44 9.23 35 193830 92541 90342041
Hepatic enzyme increased 102.09 9.23 411 193454 360325 90074257
Tenosynovitis 101.54 9.23 140 193725 14427 90420155
Sinusitis 101.49 9.23 384 193481 342704 90091878
Nocardiosis 101.06 9.23 65 193800 2505 90432077
Diabetes mellitus 100.87 9.23 337 193528 64538 90370044
Hirsutism 100.46 9.23 56 193809 1654 90432928
Oral administration complication 100.34 9.23 27 193838 87 90434495
Leukaemia recurrent 99.96 9.23 53 193812 1414 90433168
Staphylococcal bacteraemia 99.40 9.23 100 193765 7369 90427213
Dislocation of vertebra 98.88 9.23 5 193860 55963 90378619
Cutaneous T-cell lymphoma 97.77 9.23 54 193811 1566 90433016
Adjustment disorder with depressed mood 97.39 9.23 6 193859 56747 90377835
Focal segmental glomerulosclerosis 96.32 9.23 56 193809 1795 90432787
Respiratory failure 95.52 9.23 503 193362 117915 90316667
Aplasia pure red cell 95.03 9.23 83 193782 5111 90429471
Psoriasis 94.52 9.23 590 193275 147164 90287418
Ankylosing spondylitis 94.23 9.23 128 193737 13005 90421577
Electrocardiogram QT prolonged 94.09 9.23 20 193845 72436 90362146
Autoimmune disorder 94.07 9.23 24 193841 76720 90357862
Mobility decreased 92.70 9.23 254 193611 250480 90184102
Bacteraemia 92.51 9.23 169 193696 22131 90412451
Bacterial sepsis 92.31 9.23 80 193785 4875 90429707
Stomatitis 90.94 9.23 293 193572 274405 90160177
Chronic graft versus host disease in eye 90.22 9.23 29 193836 197 90434385
Nephrotic syndrome 89.95 9.23 94 193771 7245 90427337
Bone marrow failure 89.61 9.23 207 193658 32014 90402568
Pancytopenia 89.01 9.23 499 193366 119764 90314818
Death 88.65 9.23 592 193273 455959 89978623
Encephalitis viral 87.46 9.23 53 193812 1836 90432746
Klebsiella infection 87.35 9.23 109 193756 10188 90424394
Paroxysmal nocturnal haemoglobinuria 87.14 9.23 31 193834 297 90434285
Splenomegaly 86.78 9.23 122 193743 12802 90421780
Erythema 86.64 9.23 809 193056 228437 90206145
Rash pruritic 85.68 9.23 376 193489 81838 90352744
Chest pain 84.35 9.23 374 193491 319271 90115311
Chorioretinopathy 84.14 9.23 40 193825 840 90433742
Hepatosplenic T-cell lymphoma 83.99 9.23 37 193828 647 90433935
Neurotoxicity 83.19 9.23 158 193707 21309 90413273
Erythema of eyelid 82.25 9.23 63 193802 3220 90431362
Graft versus host disease in lung 81.55 9.23 34 193831 516 90434066
JC virus infection 81.21 9.23 58 193807 2661 90431921
Chronic graft versus host disease oral 80.84 9.23 27 193838 210 90434372
X-ray abnormal 80.43 9.23 4 193861 45420 90389162
Somnolence 80.16 9.23 208 193657 208876 90225706
Growth retardation 79.92 9.23 49 193816 1734 90432848
Knee arthroplasty 79.79 9.23 39 193826 83143 90351439
Blood cholesterol increased 77.42 9.23 210 193655 207802 90226780
Staphylococcal infection 77.42 9.23 254 193611 48185 90386397
Gait inability 77.27 9.23 121 193744 146335 90288247
Squamous cell carcinoma 76.38 9.23 101 193764 10000 90424582
Protothecosis 76.23 9.23 31 193834 440 90434142
Blood lactate dehydrogenase increased 75.89 9.23 170 193695 25762 90408820
Renal transplant failure 74.61 9.23 40 193825 1092 90433490
Cystitis viral 74.42 9.23 26 193839 235 90434347
Hypokalaemia 74.37 9.23 103 193762 131013 90303569
Blood bilirubin increased 74.07 9.23 233 193632 43237 90391345
Migraine 74.06 9.23 188 193677 190204 90244378
Serum ferritin increased 73.89 9.23 85 193780 7296 90427286
Graft complication 73.41 9.23 27 193838 287 90434295
Live birth 73.03 9.23 39 193826 79068 90355514
Suicide attempt 72.85 9.23 35 193830 75364 90359218
Hair follicle tumour benign 72.79 9.23 29 193836 389 90434193
Cushingoid 72.60 9.23 100 193765 10295 90424287
Pneumonia fungal 72.12 9.23 82 193783 6949 90427633
Hypercholesterolaemia 71.68 9.23 66 193799 100826 90333756
Hepatic function abnormal 70.67 9.23 239 193626 46049 90388533
Dehydration 70.35 9.23 199 193666 194248 90240334
Coeliac disease 70.16 9.23 7 193858 44603 90389979
Medication error 69.40 9.23 48 193817 84604 90349978
Amnesia 69.11 9.23 78 193787 108427 90326155
Microangiopathy 68.99 9.23 44 193821 1671 90432911
Enterococcal infection 68.11 9.23 95 193770 9896 90424686
Therapy partial responder 67.32 9.23 147 193718 21896 90412686
Condition aggravated 67.23 9.23 1708 192157 593837 89840745
Pneumatosis intestinalis 67.10 9.23 57 193808 3380 90431202
Stem cell transplant 66.77 9.23 47 193818 2107 90432475
Chronic spontaneous urticaria 66.60 9.23 44 193821 1776 90432806
Cytomegalovirus chorioretinitis 66.34 9.23 49 193816 2370 90432212
Leukoencephalopathy 66.24 9.23 66 193799 4807 90429775
Disseminated intravascular coagulation 66.20 9.23 144 193721 21394 90413188
Cerebrovascular accident 66.18 9.23 101 193764 123432 90311150
Bacterial infection 65.62 9.23 151 193714 23293 90411289
Device expulsion 65.40 9.23 6 193859 40880 90393702
Lupus nephritis 64.86 9.23 65 193800 4767 90429815
Blepharospasm 64.83 9.23 19 193846 55426 90379156
Hyperhidrosis 64.23 9.23 121 193744 136184 90298398
Alanine aminotransferase abnormal 63.83 9.23 68 193797 5358 90429224
Lupus vulgaris 63.75 9.23 10 193855 45049 90389533
Tendonitis 63.55 9.23 141 193724 21231 90413351
Glomerulosclerosis 63.44 9.23 28 193837 492 90434090
Therapeutic product effect variable 63.19 9.23 40 193825 1499 90433083
Oedema peripheral 63.16 9.23 310 193555 257605 90176977
Escherichia infection 62.85 9.23 118 193747 15777 90418805
Hyponatraemia 62.52 9.23 119 193746 133419 90301163
Maternal exposure during pregnancy 62.51 9.23 482 193383 359581 90075001
Scedosporium infection 62.46 9.23 32 193833 794 90433788
Frequent bowel movements 62.17 9.23 22 193843 56913 90377669
C-reactive protein increased 62.06 9.23 627 193238 180762 90253820
Haemolytic uraemic syndrome 61.92 9.23 50 193815 2761 90431821
Hospitalisation 61.88 9.23 112 193753 127988 90306594
Lymphadenopathy 61.83 9.23 227 193638 45548 90389034
Malignant neoplasm progression 61.57 9.23 83 193782 106787 90327795
Ocular discomfort 61.49 9.23 72 193793 6298 90428284
Lactic acidosis 61.42 9.23 16 193849 50447 90384135
Fear of injection 61.11 9.23 83 193782 8432 90426150
Skin mass 60.40 9.23 77 193788 7353 90427229
Therapeutic product effect incomplete 60.12 9.23 657 193208 193239 90241343
Intentional product use issue 60.11 9.23 249 193616 216643 90217939
Syncope 59.71 9.23 121 193744 132542 90302040
Acute kidney injury 59.32 9.23 989 192876 319398 90115184
Onychomadesis 59.10 9.23 13 193852 45985 90388597
Instillation site irritation 58.96 9.23 21 193844 202 90434380
Hip arthroplasty 58.85 9.23 46 193819 76162 90358420
Abnormal sensation in eye 58.77 9.23 42 193823 1929 90432653
Arthralgia 58.35 9.23 1246 192619 777276 89657306
Eye swelling 58.09 9.23 166 193699 29220 90405362
Toxoplasmosis 57.78 9.23 40 193825 1745 90432837
Dermatitis 57.71 9.23 139 193726 22081 90412501
Idiopathic pneumonia syndrome 57.34 9.23 25 193840 426 90434156
Therapy non-responder 57.02 9.23 493 193372 136211 90298371
Opportunistic infection 56.96 9.23 43 193822 2150 90432432
Bronchiolitis obliterans syndrome 56.24 9.23 24 193841 387 90434195
Joint swelling 56.13 9.23 749 193116 502551 89932031
Headache 55.94 9.23 1412 192453 861334 89573248
Pulmonary tuberculosis 55.84 9.23 60 193805 4774 90429808
Back pain 55.31 9.23 424 193441 316751 90117831
Epstein-Barr virus associated lymphoma 55.20 9.23 28 193837 680 90433902
Eyelid oedema 55.09 9.23 93 193772 11441 90423141
Clear cell renal cell carcinoma 54.93 9.23 37 193828 1543 90433039
C-reactive protein 54.79 9.23 3 193862 31364 90403218
Loss of personal independence in daily activities 54.78 9.23 487 193378 135618 90298964
Drug tolerance decreased 54.54 9.23 172 193693 31958 90402624
Muscular weakness 54.37 9.23 242 193623 206424 90228158
Haemorrhage intracranial 54.37 9.23 108 193757 15054 90419528
Kidney fibrosis 54.07 9.23 42 193823 2192 90432390
Bradycardia 53.69 9.23 60 193805 83787 90350795
Kaposi's sarcoma 53.34 9.23 18 193847 145 90434437
Nail disorder 53.24 9.23 30 193835 59037 90375545
Fluid retention 53.24 9.23 66 193799 88025 90346557
Superficial injury of eye 53.23 9.23 23 193842 383 90434199
Pneumonia adenoviral 53.20 9.23 20 193845 227 90434355
Lupus vasculitis 53.18 9.23 26 193839 582 90434000
Progressive multifocal leukoencephalopathy 53.14 9.23 109 193756 15546 90419036
Chronic graft versus host disease in intestine 53.02 9.23 18 193847 148 90434434
Scleroderma 52.67 9.23 66 193799 6195 90428387
Palpitations 52.40 9.23 136 193729 136592 90297990
Gastrointestinal disorder 51.70 9.23 329 193536 256358 90178224
Red blood cell schistocytes present 51.66 9.23 22 193843 353 90434229
Osteoarthritis 51.60 9.23 229 193636 195501 90239081
Hepatitis C 51.38 9.23 62 193803 5598 90428984
Lymphadenectomy 51.11 9.23 32 193833 1176 90433406
Product delivery mechanism issue 51.01 9.23 24 193841 492 90434090
Pneumomediastinum 50.94 9.23 39 193826 1992 90432590
Renal tubular atrophy 50.41 9.23 29 193836 911 90433671
Drug level increased 50.26 9.23 152 193713 27610 90406972
Microsporidia infection 50.00 9.23 21 193844 325 90434257
Rectal haemorrhage 50.00 9.23 62 193803 82682 90351900
Walking aid user 49.96 9.23 8 193857 35498 90399084
Laryngitis fungal 49.83 9.23 18 193847 181 90434401
Gastroenteritis rotavirus 49.52 9.23 19 193846 229 90434353
Insomnia 49.52 9.23 465 193400 333009 90101573
Back injury 49.24 9.23 19 193846 46603 90387979
Plasmablastic lymphoma 49.15 9.23 19 193846 234 90434348
Visual acuity reduced 48.98 9.23 135 193730 23275 90411307
Herpes virus infection 48.52 9.23 64 193801 6320 90428262
Pulmonary haemorrhage 48.48 9.23 72 193793 7941 90426641
Fungal infection 48.22 9.23 200 193665 42461 90392121
Capillary leak syndrome 48.19 9.23 43 193822 2724 90431858
Pneumocystis jirovecii infection 48.17 9.23 37 193828 1899 90432683
Infection reactivation 48.10 9.23 37 193828 1903 90432679
Human polyomavirus infection 48.09 9.23 22 193843 422 90434160
Hypoglycaemia 48.08 9.23 47 193818 69801 90364781
Lung infiltration 47.91 9.23 103 193762 15179 90419403
Underdose 47.88 9.23 28 193837 53989 90380593
Laryngeal disorder 47.66 9.23 30 193835 1113 90433469
Brain abscess 47.60 9.23 43 193822 2769 90431813
Toxic leukoencephalopathy 47.58 9.23 27 193838 826 90433756
Dilatation intrahepatic duct acquired 47.45 9.23 26 193839 742 90433840
Pneumonia viral 47.36 9.23 75 193790 8748 90425834
Hypoproteinaemia 47.29 9.23 45 193820 3097 90431485
Intentional product misuse 47.28 9.23 74 193791 89530 90345052
Tongue ulceration 46.86 9.23 51 193814 4117 90430465
Hepatitis B 46.86 9.23 53 193812 4466 90430116
Device dislocation 46.85 9.23 6 193859 31476 90403106
Oral lichen planus 46.73 9.23 26 193839 765 90433817
Cerebral toxoplasmosis 46.70 9.23 32 193833 1373 90433209
Dry eye 46.64 9.23 246 193619 57685 90376897
Taste disorder 46.46 9.23 38 193827 61508 90373074
Exostosis 46.45 9.23 28 193837 53106 90381476
Diarrhoea 46.39 9.23 1595 192270 937595 89496987
Cognitive disorder 46.30 9.23 48 193817 69359 90365223
Parvovirus B19 infection 46.00 9.23 28 193837 978 90433604
Chronic kidney disease 45.95 9.23 221 193644 49970 90384612
Orthostatic hypotension 45.95 9.23 16 193849 41811 90392771
Clubbing 45.59 9.23 22 193843 478 90434104
Disseminated tuberculosis 45.43 9.23 45 193820 3254 90431328
Complications of transplanted lung 45.28 9.23 20 193845 352 90434230
Epidural lipomatosis 45.21 9.23 18 193847 241 90434341
Multiple sclerosis relapse 45.12 9.23 28 193837 52277 90382305
Engraft failure 45.02 9.23 20 193845 357 90434225
Photophobia 44.84 9.23 123 193742 21146 90413436
Cryptococcal meningoencephalitis 44.82 9.23 16 193849 155 90434427
Disseminated cryptococcosis 44.68 9.23 25 193840 744 90433838
Adenoviral hepatitis 44.61 9.23 21 193844 431 90434151
Anaphylactic reaction 44.32 9.23 330 193535 87194 90347388
Glomerulonephritis 44.25 9.23 39 193826 2431 90432151
Rheumatic disorder 44.20 9.23 45 193820 3363 90431219
Flushing 43.97 9.23 76 193789 88415 90346167
Hepatic failure 43.92 9.23 185 193680 39543 90395039
Chronic obstructive pulmonary disease 43.90 9.23 56 193809 73773 90360809
Nephroureterectomy 43.76 9.23 9 193856 3 90434579
Gait disturbance 43.65 9.23 352 193513 260144 90174438
Renal mass 43.64 9.23 39 193826 2476 90432106
Angiocentric lymphoma 43.42 9.23 24 193841 697 90433885
Hyperplasia 43.14 9.23 28 193837 1096 90433486
Fungaemia 43.02 9.23 44 193821 3306 90431276
Acute lymphocytic leukaemia recurrent 42.92 9.23 40 193825 2681 90431901
Finger deformity 42.87 9.23 9 193856 32888 90401694
Cardio-respiratory arrest 42.87 9.23 43 193822 63097 90371485
Acute respiratory distress syndrome 42.81 9.23 147 193718 28539 90406043
Serum sickness 42.75 9.23 45 193820 3497 90431085
Instillation site reaction 42.71 9.23 21 193844 476 90434106
Pyelonephritis 42.70 9.23 121 193744 21195 90413387
Pregnancy 42.42 9.23 42 193823 62005 90372577
Thrombotic thrombocytopenic purpura 42.00 9.23 48 193817 4090 90430492
Acute myeloid leukaemia recurrent 41.98 9.23 35 193830 2022 90432560
Graft versus host disease in eye 41.79 9.23 14 193851 110 90434472
Retinitis 41.75 9.23 15 193850 38443 90396139
Febrile neutropenia 41.70 9.23 520 193345 157829 90276753
Fusarium infection 41.65 9.23 27 193838 1055 90433527
Osteonecrosis 41.39 9.23 137 193728 26104 90408478
Graft loss 41.26 9.23 20 193845 439 90434143
Sedation 41.26 9.23 26 193839 48145 90386437
Injection site pain 41.23 9.23 211 193654 173488 90261094
Haemolysis 41.15 9.23 69 193796 8441 90426141
Renal tubular necrosis 41.01 9.23 94 193771 14461 90420121
Cryptococcosis 40.79 9.23 30 193835 1441 90433141
Soft tissue infection 40.79 9.23 40 193825 2857 90431725
Skin disorder 40.64 9.23 171 193694 36535 90398047
Blood stem cell transplant failure 40.54 9.23 16 193849 209 90434373
Skin neoplasm excision 40.47 9.23 32 193833 1714 90432868
Enterococcal sepsis 40.46 9.23 31 193834 1585 90432997
Bacillary angiomatosis 40.32 9.23 14 193851 124 90434458
Disease progression 40.26 9.23 512 193353 156103 90278479
Inflammation 40.20 9.23 570 193295 178022 90256560
Hepatitis E 40.19 9.23 33 193832 1866 90432716
Chest discomfort 40.12 9.23 156 193709 138209 90296373
Ovarian failure 40.01 9.23 31 193834 1612 90432970
Cellulitis staphylococcal 39.95 9.23 25 193840 918 90433664
Muscle spasticity 39.69 9.23 13 193852 35309 90399273
Product storage error 39.67 9.23 114 193751 20127 90414455
Jaw fracture 39.63 9.23 38 193827 2640 90431942
Hepatosplenomegaly 39.52 9.23 40 193825 2969 90431613
Bone marrow transplant 39.48 9.23 24 193841 836 90433746
Macular degeneration 39.24 9.23 16 193849 37954 90396628
Haemolytic anaemia 39.18 9.23 81 193784 11616 90422966
Hypertensive cardiomyopathy 39.13 9.23 17 193848 287 90434295
Pyoderma gangrenosum 39.06 9.23 48 193817 4416 90430166
Steroid dependence 39.00 9.23 35 193830 2234 90432348
International normalised ratio increased 38.55 9.23 27 193838 47289 90387293
Pulmonary nocardiosis 38.53 9.23 23 193842 775 90433807
T-cell lymphoma 38.53 9.23 23 193842 775 90433807
Adrenal suppression 38.40 9.23 25 193840 984 90433598
Squamous cell carcinoma of skin 38.18 9.23 62 193803 7387 90427195
Growth failure 38.17 9.23 18 193847 371 90434211
Oedema 38.16 9.23 261 193604 200034 90234548
Granuloma 38.03 9.23 56 193809 6129 90428453
Joint stiffness 37.89 9.23 68 193797 77974 90356608
Hypersensitivity 37.78 9.23 715 193150 453962 89980620
Bone marrow transplant rejection 37.65 9.23 12 193853 79 90434503
Escherichia urinary tract infection 37.59 9.23 88 193777 13727 90420855
Swelling of eyelid 37.39 9.23 52 193813 5402 90429180
Hyperbilirubinaemia 37.08 9.23 88 193777 13848 90420734
Fibroadenoma of breast 36.72 9.23 23 193842 846 90433736
Acinetobacter infection 36.56 9.23 32 193833 1976 90432606
Leukaemia in remission 36.50 9.23 9 193856 18 90434564
Cardiac failure congestive 36.43 9.23 100 193765 98594 90335988
Vulvovaginal erythema 36.36 9.23 20 193845 575 90434007
Enterococcal bacteraemia 36.29 9.23 32 193833 1996 90432586
Laryngitis 36.28 9.23 33 193832 50720 90383862
Polyomavirus-associated nephropathy 36.22 9.23 35 193830 2455 90432127
Mechanical ventilation 36.17 9.23 28 193837 1454 90433128
Penicillium infection 36.15 9.23 16 193849 283 90434299
Post transplant distal limb syndrome 36.06 9.23 17 193848 350 90434232
Eyelid disorder 35.94 9.23 33 193832 2170 90432412
Eye inflammation 35.78 9.23 62 193803 7789 90426793
Rheumatoid lung 35.71 9.23 44 193821 4059 90430523
Lymphocytic infiltration 35.71 9.23 25 193840 1111 90433471
Transaminases increased 35.67 9.23 166 193699 37026 90397556
Myopathy 35.58 9.23 85 193780 13433 90421149
Systemic mycosis 35.38 9.23 28 193837 1502 90433080
Adenovirus reactivation 35.37 9.23 15 193850 238 90434344
Engraftment syndrome 35.27 9.23 21 193844 704 90433878
Haptoglobin decreased 35.25 9.23 24 193841 1019 90433563
Multiple use of single-use product 35.11 9.23 30 193835 1793 90432789
Staphylococcal sepsis 35.05 9.23 68 193797 9315 90425267
Haematuria 35.04 9.23 158 193707 34779 90399803
Pulmonary alveolar haemorrhage 35.01 9.23 53 193812 5945 90428637
Epicondylitis 35.01 9.23 35 193830 2559 90432023
Lymphocele marsupialisation 34.73 9.23 8 193857 10 90434572
Papilloedema 34.67 9.23 46 193819 4569 90430013
Haemodialysis 34.66 9.23 65 193800 8682 90425900
Gouty tophus 34.49 9.23 15 193850 254 90434328
Tuberculosis gastrointestinal 34.43 9.23 17 193848 389 90434193
Anti-cyclic citrullinated peptide antibody 34.36 9.23 8 193857 27213 90407369
Product quality issue 34.30 9.23 74 193791 79251 90355331
Renal disorder 34.15 9.23 166 193699 37693 90396889
Cytomegalovirus enterocolitis 34.11 9.23 22 193843 852 90433730
Alpha haemolytic streptococcal infection 34.06 9.23 29 193836 1725 90432857
Blood urea increased 33.91 9.23 142 193723 30271 90404311
Full blood count abnormal 33.84 9.23 18 193847 36579 90398003
Mouth ulceration 33.73 9.23 172 193693 39802 90394780
Epidermodysplasia verruciformis 33.71 9.23 13 193852 159 90434423
Onychomycosis 33.66 9.23 19 193846 37357 90397225
Complications of transplanted heart 33.64 9.23 12 193853 116 90434466
Iris adhesions 33.62 9.23 17 193848 410 90434172
Eyelid irritation 33.60 9.23 23 193842 985 90433597
Pericardial effusion 33.58 9.23 162 193703 36671 90397911
Pneumonia klebsiella 33.52 9.23 37 193828 3035 90431547
Pain in extremity 33.38 9.23 722 193143 449807 89984775
Muscle fatigue 33.26 9.23 36 193829 2888 90431694
Thrombocytopenia 33.14 9.23 629 193236 208096 90226486
Interstitial lung disease 33.14 9.23 278 193587 76127 90358455
Autoimmune haemolytic anaemia 33.12 9.23 50 193815 5595 90428987
Procedural pain 32.97 9.23 15 193850 33345 90401237
Nephrectomy 32.96 9.23 30 193835 1951 90432631
Neoplasm progression 32.92 9.23 28 193837 44458 90390124
Platelet count decreased 32.78 9.23 442 193423 136527 90298055
Musculoskeletal stiffness 32.75 9.23 442 193423 296090 90138492
Glomerulonephritis membranous 32.74 9.23 20 193845 703 90433879
Synovitis 32.74 9.23 502 193363 329250 90105332
Injection site erythema 32.60 9.23 105 193760 98397 90336185
Anuria 32.55 9.23 87 193778 14731 90419851
Disability 32.22 9.23 24 193841 40721 90393861
Rash 32.20 9.23 1384 192481 794716 89639866
Life support 32.19 9.23 14 193851 237 90434345
Metapneumovirus infection 32.10 9.23 25 193840 1310 90433272
Balance disorder 31.77 9.23 104 193761 96976 90337606
Rhabdomyolysis 31.71 9.23 203 193662 51053 90383529
Respiratory tract infection bacterial 31.64 9.23 17 193848 466 90434116
Asthenopia 31.63 9.23 35 193830 2879 90431703
Hypouricaemia 31.51 9.23 14 193851 250 90434332
Gastroenteritis clostridial 31.41 9.23 19 193846 656 90433926
Lung disorder 31.25 9.23 190 193675 149693 90284889
Eyelids pruritus 31.23 9.23 29 193836 1935 90432647
Vulvovaginal candidiasis 31.05 9.23 40 193825 3860 90430722
Iron overload 30.93 9.23 22 193843 1003 90433579
Intentional self-injury 30.91 9.23 12 193853 29322 90405260
Eye infection toxoplasmal 30.90 9.23 16 193849 406 90434176
Lichenification 30.50 9.23 17 193848 502 90434080
Juvenile idiopathic arthritis 30.43 9.23 40 193825 3937 90430645
Cough 30.38 9.23 581 193284 368381 90066201
Serotonin syndrome 30.37 9.23 22 193843 37865 90396717
Agitation 30.35 9.23 61 193804 67037 90367545
Rebound effect 30.29 9.23 64 193801 9320 90425262
Exposure during pregnancy 30.22 9.23 345 193520 238065 90196517
Guillain-Barre syndrome 30.17 9.23 43 193822 4569 90430013
Gastroenteritis norovirus 30.14 9.23 31 193834 2345 90432237
Genital ulceration 30.02 9.23 22 193843 1051 90433531
Concomitant disease progression 29.91 9.23 30 193835 2202 90432380
Low birth weight baby 29.90 9.23 64 193801 9403 90425179
Concomitant disease aggravated 29.85 9.23 72 193793 11446 90423136
Drug withdrawal syndrome 29.85 9.23 12 193853 28711 90405871
Epilepsy 29.81 9.23 84 193781 82122 90352460
Osteonecrosis of jaw 29.69 9.23 24 193841 39079 90395503
Restlessness 29.61 9.23 20 193845 35700 90398882
Retinal haemorrhage 29.57 9.23 48 193817 5716 90428866
Neoplasm skin 29.48 9.23 35 193830 3107 90431475
Hypertensive encephalopathy 29.45 9.23 19 193846 736 90433846
Dyschromatopsia 29.41 9.23 19 193846 738 90433844
Expired product administered 29.40 9.23 53 193812 6869 90427713
Blood immunoglobulin M increased 29.37 9.23 24 193841 1348 90433234
Eyelid pain 28.82 9.23 19 193846 764 90433818
Mycoplasma infection 28.78 9.23 20 193845 878 90433704
Influenza like illness 28.77 9.23 83 193782 80528 90354054
Drug tolerance 28.67 9.23 94 193771 17822 90416760
Abdominal distension 28.58 9.23 163 193702 130438 90304144
Pre-eclampsia 28.57 9.23 69 193796 10979 90423603
Complications of transplant surgery 28.55 9.23 12 193853 186 90434396
Actinomycotic sepsis 28.53 9.23 13 193852 247 90434335
Parvovirus infection 28.39 9.23 16 193849 483 90434099
Candida infection 28.36 9.23 146 193719 33911 90400671
Toxic shock syndrome 28.30 9.23 21 193844 1023 90433559
Product label confusion 28.28 9.23 7 193858 22843 90411739
Cytomegalovirus syndrome 28.28 9.23 10 193855 94 90434488
Arthritis 28.22 9.23 509 193356 166806 90267776
Biloma 28.09 9.23 10 193855 96 90434486
Microangiopathic haemolytic anaemia 28.04 9.23 19 193846 800 90433782
Renal lymphocele 28.02 9.23 9 193856 61 90434521
Product dose omission issue 27.95 9.23 447 193418 291240 90143342
Ileal ulcer 27.91 9.23 21 193844 1045 90433537
Endocrine ophthalmopathy 27.77 9.23 21 193844 1053 90433529
Haemosiderosis 27.65 9.23 12 193853 202 90434380
MELAS syndrome 27.55 9.23 12 193853 204 90434378
Cerebral vasoconstriction 27.29 9.23 22 193843 1212 90433370
Streptococcal infection 27.22 9.23 53 193812 7280 90427302
Pain of skin 27.21 9.23 86 193779 15996 90418586
Peripheral T-cell lymphoma unspecified 27.13 9.23 13 193852 278 90434304
Steroid diabetes 27.07 9.23 30 193835 2472 90432110
Oxygen saturation decreased 26.98 9.23 128 193737 107355 90327227
Ulcerative keratitis 26.84 9.23 35 193830 3418 90431164
Blast crisis in myelogenous leukaemia 26.69 9.23 17 193848 644 90433938
Sleep disorder due to a general medical condition 26.53 9.23 34 193831 44704 90389878
Sinus tachycardia 26.40 9.23 14 193851 28499 90406083
Gastroenteritis adenovirus 26.39 9.23 13 193852 296 90434286
Femur fracture 26.32 9.23 36 193829 46046 90388536
Drug interaction 26.31 9.23 776 193089 275677 90158905
Central nervous system lymphoma 26.30 9.23 27 193838 2038 90432544
Premature delivery 26.16 9.23 157 193708 38605 90395977
Vulvovaginal swelling 26.15 9.23 18 193847 778 90433804
Blood immunoglobulin A decreased 26.14 9.23 25 193840 1731 90432851
Anaemia macrocytic 26.12 9.23 40 193825 4532 90430050
Lupus-like syndrome 26.09 9.23 40 193825 48806 90385776
Gastropleural fistula 26.02 9.23 8 193857 46 90434536
Feeling hot 25.92 9.23 83 193782 77925 90356657
Tuberculosis 25.89 9.23 72 193793 12477 90422105
Guttate psoriasis 25.88 9.23 16 193849 575 90434007
Unresponsive to stimuli 25.83 9.23 26 193839 38095 90396487
American trypanosomiasis 25.82 9.23 12 193853 239 90434343
Blindness cortical 25.78 9.23 16 193849 579 90434003
Haemorrhagic diathesis 25.67 9.23 44 193821 5480 90429102
Short stature 25.64 9.23 20 193845 1050 90433532
Angiosarcoma 25.64 9.23 12 193853 243 90434339
Hilar lymphadenopathy 25.59 9.23 22 193843 1326 90433256
Angioedema 25.51 9.23 231 193634 64645 90369937
Cataract 25.50 9.23 251 193614 71841 90362741
B-cell lymphoma 25.35 9.23 35 193830 3611 90430971
Renal cell carcinoma 25.33 9.23 36 193829 3815 90430767
Infusion site reaction 25.24 9.23 5 193860 19034 90415548
Cardiac arrest 25.16 9.23 127 193738 104808 90329774
Hepatic artery stenosis 25.14 9.23 9 193856 88 90434494
Herpes simplex pneumonia 25.14 9.23 9 193856 88 90434494
Pneumonia lipoid 25.11 9.23 10 193855 134 90434448
Dysplasia 24.95 9.23 22 193843 1372 90433210
Drug level fluctuating 24.90 9.23 15 193850 514 90434068
Haemorrhage urinary tract 24.88 9.23 20 193845 1097 90433485
Autoimmune thyroiditis 24.87 9.23 45 193820 5848 90428734
Glomerulonephritis membranoproliferative 24.82 9.23 13 193852 338 90434244
Infertility 24.76 9.23 18 193847 849 90433733
Impetigo herpetiformis 24.71 9.23 10 193855 140 90434442
Peripheral swelling 24.59 9.23 684 193181 412422 90022160
Hepatic enzyme abnormal 24.52 9.23 52 193813 7590 90426992
Atrial fibrillation 24.51 9.23 176 193689 133435 90301147
Sopor 24.48 9.23 11 193854 24633 90409949
Focal nodular hyperplasia 24.29 9.23 17 193848 755 90433827
Product packaging quantity issue 24.22 9.23 23 193842 1579 90433003
Rectal cancer metastatic 24.17 9.23 12 193853 278 90434304
Congenital coronary artery malformation 24.15 9.23 10 193855 149 90434433
Hiatus hernia 24.15 9.23 12 193853 25349 90409233
Burkholderia cepacia complex infection 24.14 9.23 11 193854 209 90434373
Maternal exposure timing unspecified 24.01 9.23 9 193856 22474 90412108
Coxsackie virus test positive 24.01 9.23 6 193859 13 90434569
Chorioretinal folds 24.01 9.23 6 193859 13 90434569
Klebsiella sepsis 23.98 9.23 24 193841 1757 90432825
Papilloma viral infection 23.97 9.23 24 193841 1758 90432824
Eye disorder 23.92 9.23 119 193746 27271 90407311
Gamma-glutamyltransferase increased 23.90 9.23 151 193714 37801 90396781
Eye infection fungal 23.79 9.23 10 193855 155 90434427
Infected neoplasm 23.79 9.23 13 193852 369 90434213
Eye complication associated with device 23.70 9.23 6 193859 14 90434568
Blood potassium decreased 23.70 9.23 41 193824 47686 90386896
Pseudomonal sepsis 23.69 9.23 37 193828 4265 90430317
Herpes ophthalmic 23.64 9.23 22 193843 1472 90433110
Peritonitis 23.55 9.23 94 193771 19611 90414971
Stenotrophomonas infection 23.44 9.23 28 193837 2501 90432081
Transient ischaemic attack 23.41 9.23 35 193830 43141 90391441
Weight decreased 23.39 9.23 626 193239 379284 90055298
Weber tuning fork test abnormal 23.34 9.23 9 193856 110 90434472
Eyelid exfoliation 23.34 9.23 12 193853 300 90434282
Gastrointestinal mucormycosis 23.27 9.23 12 193853 302 90434280
Loss of consciousness 23.24 9.23 190 193675 140048 90294534
Product use complaint 23.20 9.23 33 193832 3500 90431082
Conjunctival oedema 22.98 9.23 18 193847 951 90433631
Conjunctival hyperaemia 22.91 9.23 31 193834 3138 90431444
Blood immunoglobulin G increased 22.91 9.23 30 193835 2942 90431640
Systemic inflammatory response syndrome 22.87 9.23 46 193819 6470 90428112
Myelodysplastic syndrome 22.84 9.23 97 193768 20806 90413776
Escherichia sepsis 22.77 9.23 43 193822 5773 90428809
Sinus disorder 22.77 9.23 24 193841 34423 90400159
Stenotrophomonas sepsis 22.52 9.23 7 193858 42 90434540
Caesarean section 22.51 9.23 89 193776 18488 90416094
Proctitis 22.48 9.23 3 193862 15256 90419326
Squamous cell carcinoma of the oral cavity 22.46 9.23 13 193852 413 90434169
Gastroenteritis astroviral 22.46 9.23 8 193857 77 90434505
Organising pneumonia 22.45 9.23 50 193815 7547 90427035
Respiratory tract infection fungal 22.42 9.23 14 193851 512 90434070
Device difficult to use 22.42 9.23 5 193860 17520 90417062
Vascular hyalinosis 22.38 9.23 7 193858 43 90434539
Morphoea 22.35 9.23 13 193852 417 90434165
Neoplasm recurrence 22.23 9.23 31 193834 3228 90431354
T-lymphocyte count abnormal 22.14 9.23 6 193859 20 90434562
Meningoradiculitis 22.12 9.23 9 193856 128 90434454
Laryngitis viral 22.10 9.23 8 193857 81 90434501
Reversible cerebral vasoconstriction syndrome 22.02 9.23 35 193830 4095 90430487
Bronchostenosis 22.01 9.23 14 193851 529 90434053
Ear infection 21.98 9.23 76 193789 69699 90364883
Chemokine increased 21.92 9.23 6 193859 21 90434561
Herpes zoster infection neurological 21.92 9.23 14 193851 533 90434049
Primary hypogonadism 21.80 9.23 10 193855 193 90434389
Lung consolidation 21.77 9.23 38 193827 4802 90429780
Lacrimation decreased 21.72 9.23 13 193852 440 90434142
Fungal test positive 21.69 9.23 14 193851 543 90434039
Hepatitis B reactivation 21.63 9.23 34 193831 3940 90430642
Pain in jaw 21.56 9.23 176 193689 47809 90386773
Fungal endocarditis 21.51 9.23 12 193853 355 90434227
Intussusception 21.49 9.23 18 193847 1047 90433535
Metastases to liver 21.48 9.23 18 193847 28789 90405793
Genital cyst 21.47 9.23 7 193858 50 90434532
Cytopenia 21.47 9.23 84 193781 17365 90417217
Intracranial pressure increased 21.46 9.23 46 193819 6765 90427817
Hepatomegaly 21.40 9.23 70 193795 13256 90421326
Oesophageal candidiasis 21.38 9.23 46 193819 6783 90427799
Mycobacterial infection 21.37 9.23 25 193840 2185 90432397
Varicella 21.30 9.23 26 193839 2376 90432206
Clonal evolution 21.27 9.23 8 193857 91 90434491
Dysbiosis 21.22 9.23 22 193843 1680 90432902
Porokeratosis 21.21 9.23 9 193856 143 90434439
Renal tubular disorder 21.13 9.23 30 193835 3177 90431405
Nasal septum disorder 21.12 9.23 10 193855 208 90434374
Reticulocyte count increased 21.05 9.23 18 193847 1077 90433505
Sleep disorder due to general medical condition, insomnia type 21.04 9.23 175 193690 128519 90306063
Muscular dystrophy 21.01 9.23 7 193858 54 90434528
Weight fluctuation 20.94 9.23 8 193857 19741 90414841
Cutaneous T-cell lymphoma stage IV 20.91 9.23 6 193859 26 90434556
Rheumatoid arthritis 20.87 9.23 962 192903 361652 90072930
Infected dermal cyst 20.86 9.23 13 193852 474 90434108
Measles 20.74 9.23 12 193853 381 90434201
Raoultella ornithinolytica infection 20.73 9.23 8 193857 98 90434484
Pruritus allergic 20.73 9.23 22 193843 1726 90432856
Aqueous humour leakage 20.60 9.23 4 193861 0 90434582
Oral lichenoid reaction 20.59 9.23 8 193857 100 90434482
BK polyomavirus test positive 20.55 9.23 9 193856 155 90434427
Colitis erosive 20.53 9.23 10 193855 222 90434360
Rash pustular 20.53 9.23 50 193815 7999 90426583
Immune thrombocytopenia 20.51 9.23 69 193796 13257 90421325
Secondary adrenocortical insufficiency 20.40 9.23 25 193840 2293 90432289
Ulcer haemorrhage 20.18 9.23 16 193849 26305 90408277
Poisoning 20.17 9.23 4 193861 15213 90419369
Cytomegalovirus oesophagitis 20.11 9.23 12 193853 404 90434178
Torsade de pointes 20.10 9.23 4 193861 15178 90419404
Urinary retention 20.07 9.23 31 193834 37713 90396869
Transplant abscess 20.05 9.23 6 193859 31 90434551
Biopsy kidney abnormal 20.05 9.23 6 193859 31 90434551
Idiopathic intracranial hypertension 20.00 9.23 31 193834 3550 90431032
Seronegative arthritis 19.98 9.23 7 193858 18227 90416355
Immunosuppression 19.90 9.23 64 193801 12013 90422569
Viral test positive 19.86 9.23 14 193851 629 90433953
Cholangitis 19.81 9.23 46 193819 7136 90427446
Oesophageal stenosis 19.76 9.23 32 193833 3804 90430778
Bladder hypertrophy 19.74 9.23 13 193852 522 90434060
Ureaplasma infection 19.73 9.23 16 193849 889 90433693
Reticulocytosis 19.71 9.23 10 193855 243 90434339
Adenoviral haemorrhagic cystitis 19.70 9.23 9 193856 172 90434410
Acute myeloid leukaemia 19.70 9.23 92 193773 20548 90414034
Xanthoma 19.68 9.23 7 193858 67 90434515
Streptococcal bacteraemia 19.57 9.23 24 193841 2203 90432379
Groin pain 19.47 9.23 64 193801 12149 90422433
Vaccination failure 19.46 9.23 18 193847 1195 90433387
Chloroma 19.45 9.23 10 193855 250 90434332
Platelet count abnormal 19.45 9.23 34 193831 4301 90430281
Molluscum contagiosum 19.43 9.23 11 193854 335 90434247
Renal arteriosclerosis 19.42 9.23 9 193856 178 90434404
Gastrointestinal stromal tumour 19.41 9.23 19 193846 1354 90433228
Punctate keratitis 19.34 9.23 15 193850 781 90433801
Oedema mucosal 19.33 9.23 18 193847 1205 90433377
Urticaria pressure 19.32 9.23 7 193858 71 90434511
Parakeratosis 19.31 9.23 11 193854 339 90434243
Corneal lesion 19.30 9.23 6 193859 36 90434546
Overdose 19.28 9.23 230 193635 157479 90277103
Apoptosis 19.27 9.23 8 193857 120 90434462
Cytogenetic abnormality 19.24 9.23 13 193852 545 90434037
Head injury 19.23 9.23 23 193842 31165 90403417
Central obesity 19.21 9.23 19 193846 1371 90433211
Acute myocardial infarction 19.19 9.23 28 193837 34862 90399720
Demyelinating polyneuropathy 19.17 9.23 16 193849 926 90433656
Epstein-Barr virus antibody positive 19.16 9.23 11 193854 344 90434238
Laryngeal mass 19.16 9.23 6 193859 37 90434545
Lysozyme increased 19.10 9.23 5 193860 14 90434568
Therapy interrupted 19.07 9.23 50 193815 50058 90384524
Oral disorder 19.06 9.23 57 193808 10288 90424294
Presyncope 19.03 9.23 24 193841 31781 90402801
Generalised oedema 18.98 9.23 86 193779 18967 90415615
Diabetic macroangiopathy 18.98 9.23 8 193857 125 90434457
Paraspinal abscess 18.92 9.23 10 193855 265 90434317
Glutamate dehydrogenase level abnormal 18.85 9.23 5 193860 15 90434567
Chronic sinusitis 18.84 9.23 14 193851 23788 90410794
Alopecia scarring 18.68 9.23 9 193856 195 90434387
Bone erosion 18.62 9.23 55 193810 52966 90381616
Pneumonia bacterial 18.61 9.23 65 193800 12725 90421857
Ureteric stenosis 18.58 9.23 14 193851 698 90433884
Metastatic malignant melanoma 18.48 9.23 20 193845 1604 90432978
Adverse drug reaction 18.48 9.23 160 193705 116541 90318041
Calcification of muscle 18.47 9.23 9 193856 200 90434382
Atypical mycobacterial infection 18.46 9.23 20 193845 1606 90432976
Stab wound 18.42 9.23 7 193858 82 90434500
Urinary tract infection viral 18.42 9.23 7 193858 82 90434500
Mycobacterium kansasii infection 18.42 9.23 8 193857 135 90434447
Interleukin level increased 18.41 9.23 14 193851 708 90433874
Acute graft versus host disease oral 18.39 9.23 6 193859 43 90434539
Encephalitis 18.34 9.23 59 193806 11075 90423507
Cerebral venous sinus thrombosis 18.34 9.23 24 193841 2352 90432230
Madarosis 18.32 9.23 30 193835 3599 90430983
Transitional cell carcinoma 18.32 9.23 14 193851 713 90433869
Pneumonia pseudomonal 18.27 9.23 28 193837 3175 90431407
Enterobacter infection 18.27 9.23 25 193840 2558 90432024
Lacrimal disorder 18.23 9.23 10 193855 286 90434296
Lichen planus 18.23 9.23 26 193839 2765 90431817
Blood glucose increased 18.18 9.23 124 193741 95122 90339460
Human herpesvirus 8 infection 18.18 9.23 11 193854 380 90434202
Meningitis cryptococcal 18.16 9.23 21 193844 1812 90432770
Withdrawal syndrome 18.15 9.23 13 193852 22511 90412071
Herpes simplex reactivation 18.07 9.23 16 193849 1003 90433579
Hair growth abnormal 18.03 9.23 30 193835 3646 90430936
Lipids increased 18.03 9.23 18 193847 1314 90433268
Biliary tract disorder 18.02 9.23 15 193850 865 90433717
Drug effective for unapproved indication 17.91 9.23 47 193818 7871 90426711
Vulval disorder 17.89 9.23 18 193847 1326 90433256
Septic vasculitis 17.83 9.23 4 193861 4 90434578
Sinus bradycardia 17.75 9.23 7 193858 16945 90417637
Aortitis salmonella 17.74 9.23 5 193860 20 90434562
Brain oedema 17.72 9.23 79 193786 17306 90417276
Globulins decreased 17.70 9.23 11 193854 399 90434183
Injection site swelling 17.64 9.23 67 193798 59772 90374810
Schizophrenia 17.64 9.23 5 193860 14909 90419673
Acidosis hyperchloraemic 17.63 9.23 15 193850 891 90433691
Portal vein embolism 17.63 9.23 7 193858 93 90434489
Gallbladder rupture 17.61 9.23 12 193853 510 90434072
Poikiloderma 17.56 9.23 10 193855 308 90434274
Hairy cell leukaemia 17.55 9.23 5 193860 21 90434561
Hypoalbuminaemia 17.55 9.23 74 193791 15823 90418759
Leukaemoid reaction 17.54 9.23 9 193856 224 90434358
Pyrexia 17.49 9.23 1640 192225 658845 89775737
Rhinitis allergic 17.46 9.23 7 193858 16778 90417804
Keratitis 17.43 9.23 31 193834 3975 90430607
Acarodermatitis 17.43 9.23 18 193847 1368 90433214
Tachycardia 17.40 9.23 235 193630 157438 90277144
Giant cell myocarditis 17.36 9.23 5 193860 22 90434560
Cryptosporidiosis infection 17.31 9.23 11 193854 415 90434167
Laboratory test abnormal 17.31 9.23 40 193825 41814 90392768
Red blood cell abnormality 17.30 9.23 12 193853 525 90434057
Radiculopathy 17.26 9.23 9 193856 18496 90416086
Oliguria 17.23 9.23 56 193809 10568 90424014
Serratia infection 17.21 9.23 16 193849 1069 90433513
Laser therapy 17.20 9.23 6 193859 54 90434528
Renal-limited thrombotic microangiopathy 17.18 9.23 9 193856 234 90434348
Skin toxicity 17.17 9.23 42 193823 6737 90427845
Full blood count decreased 17.15 9.23 23 193842 29666 90404916
Impaired work ability 17.15 9.23 10 193855 19316 90415266
Obstructive airways disorder 17.13 9.23 18 193847 25851 90408731
Viral vasculitis 17.05 9.23 7 193858 102 90434480
Injection site reaction 17.03 9.23 121 193744 91959 90342623
Dermatopathic lymphadenopathy 17.01 9.23 5 193860 24 90434558
Arterial thrombosis 16.99 9.23 19 193846 1581 90433001
Skin hyperpigmentation 16.88 9.23 42 193823 6809 90427773
Hypertrophy of tongue papillae 16.84 9.23 5 193860 25 90434557
Galectin-3 increased 16.84 9.23 5 193860 25 90434557
Blood calcium decreased 16.82 9.23 24 193841 30158 90404424
Foot deformity 16.81 9.23 68 193797 59583 90374999
Blood alkaline phosphatase increased 16.81 9.23 167 193698 47912 90386670
Suicidal ideation 16.80 9.23 91 193774 73764 90360818
Coma 16.79 9.23 89 193776 72543 90362039
Dermatitis exfoliative generalised 16.74 9.23 37 193828 5556 90429026
Metamorphopsia 16.68 9.23 18 193847 1439 90433143
Tuberculous tenosynovitis 16.57 9.23 4 193861 7 90434575
Kidney enlargement 16.55 9.23 14 193851 825 90433757
Disseminated Bacillus Calmette-Guerin infection 16.55 9.23 6 193859 61 90434521
Glomerulonephritis proliferative 16.55 9.23 9 193856 253 90434329
End stage renal disease 16.53 9.23 48 193817 8523 90426059
Ciliary body disorder 16.52 9.23 5 193860 27 90434555
Hepatic fibrosis 16.51 9.23 31 193834 4144 90430438
Breath sounds abnormal 16.50 9.23 71 193794 15315 90419267
Atypical haemolytic uraemic syndrome 16.47 9.23 15 193850 976 90433606
Cholangitis infective 16.43 9.23 11 193854 454 90434128
Petechiae 16.40 9.23 72 193793 15669 90418913
Septic embolus 16.39 9.23 15 193850 982 90433600
Corneal abrasion 16.39 9.23 17 193848 1299 90433283
Mucosal ulceration 16.38 9.23 16 193849 1137 90433445
Tenderness 16.36 9.23 106 193759 26762 90407820
Upper gastrointestinal haemorrhage 16.35 9.23 15 193850 22961 90411621
Corneal transplant 16.33 9.23 10 193855 353 90434229
Psoriasis area severity index increased 16.33 9.23 8 193857 180 90434402
Serum amyloid A protein increased 16.32 9.23 13 193852 704 90433878
Breast cancer metastatic 16.26 9.23 6 193859 15126 90419456
Clonic convulsion 16.25 9.23 14 193851 846 90433736
Moraxella infection 16.24 9.23 11 193854 463 90434119
Encephalitis cytomegalovirus 16.24 9.23 13 193852 709 90433873
Cholestasis 16.23 9.23 133 193732 36166 90398416
Megakaryocytes decreased 16.23 9.23 5 193860 29 90434553
Primary effusion lymphoma 16.22 9.23 4 193861 8 90434574
Prescribed underdose 16.21 9.23 94 193771 74925 90359657
Renal transplant 16.16 9.23 19 193846 1669 90432913
Encapsulating peritoneal sclerosis 16.13 9.23 10 193855 361 90434221
Skin lesion removal 16.13 9.23 6 193859 66 90434516
Type IIb hyperlipidaemia 16.08 9.23 5 193860 30 90434552
Tubulointerstitial nephritis 16.06 9.23 101 193764 25242 90409340
Sciatica 16.05 9.23 139 193726 101243 90333339
Bone pain 16.03 9.23 73 193792 61910 90372672
Photosensitivity reaction 16 9.23 78 193787 17729 90416853
Dyspnoea exertional 15.93 9.23 90 193775 72198 90362384
Ascites 15.82 9.23 164 193701 47576 90387006
Osteomalacia 15.77 9.23 14 193851 881 90433701
Toxicity to various agents 15.75 9.23 482 193383 287364 90147218
Choroidal detachment 15.72 9.23 9 193856 280 90434302
Back disorder 15.70 9.23 19 193846 25612 90408970
Bile duct stenosis 15.68 9.23 19 193846 1723 90432859
Exercise tolerance increased 15.68 9.23 5 193860 33 90434549
Pneumonia staphylococcal 15.62 9.23 28 193837 3613 90430969
Lens disorder 15.60 9.23 8 193857 199 90434383
Eastern Cooperative Oncology Group performance status 15.56 9.23 7 193858 129 90434453
CD4 lymphocytes increased 15.52 9.23 8 193857 201 90434381
Drug level decreased 15.52 9.23 51 193814 9679 90424903
Punctal plug insertion 15.45 9.23 3 193862 0 90434582
Ewing's sarcoma recurrent 15.45 9.23 3 193862 0 90434582
Jejunal ulcer perforation 15.43 9.23 5 193860 35 90434547
Eyelid margin crusting 15.42 9.23 19 193846 1753 90432829
Injection site pruritus 15.40 9.23 61 193804 53773 90380809
Fasciitis 15.40 9.23 12 193853 629 90433953
Gingival bleeding 15.40 9.23 68 193797 14835 90419747
Ophthalmic herpes simplex 15.37 9.23 12 193853 631 90433951
Chronic myeloid leukaemia recurrent 15.35 9.23 9 193856 293 90434289
Rash vesicular 15.34 9.23 10 193855 18187 90416395
Septic arthritis streptococcal 15.34 9.23 4 193861 11 90434571
Parainfluenzae virus infection 15.28 9.23 24 193841 2779 90431803
Aspergillus test positive 15.22 9.23 10 193855 400 90434182
Skin maceration 15.21 9.23 8 193857 210 90434372
Immune reconstitution inflammatory syndrome 15.20 9.23 41 193824 6978 90427604
Bone marrow myelogram abnormal 15.19 9.23 5 193860 37 90434545
Rhinovirus infection 15.16 9.23 37 193828 5926 90428656
Inappropriate antidiuretic hormone secretion 15.13 9.23 82 193783 19423 90415159
Joint dislocation 15.12 9.23 47 193818 44535 90390047
Glycosuria 15.10 9.23 17 193848 1425 90433157
Erythrodermic psoriasis 15.07 9.23 15 193850 1091 90433491
Incorrect dose administered 15.07 9.23 245 193620 78685 90355897
Diabetic ketoacidosis 15.04 9.23 18 193847 24389 90410193
Meningism 15.04 9.23 11 193854 524 90434058
Central nervous system vasculitis 15.04 9.23 15 193850 1094 90433488
Aplasia 15.00 9.23 29 193836 3962 90430620
Eating disorder 14.98 9.23 23 193842 28050 90406532
Urinary tract infection pseudomonal 14.95 9.23 14 193851 944 90433638
Polyserositis 14.89 9.23 12 193853 661 90433921
Adjusted calcium decreased 14.87 9.23 8 193857 220 90434362
Hepatosplenic abscess 14.84 9.23 4 193861 13 90434569
Instillation site dryness 14.84 9.23 4 193861 13 90434569
Still's disease 14.84 9.23 4 193861 13 90434569
Corynebacterium infection 14.83 9.23 14 193851 954 90433628
Intervertebral disc protrusion 14.79 9.23 22 193843 27174 90407408
Allogenic stem cell transplantation 14.77 9.23 7 193858 146 90434436
Megakaryocytes increased 14.76 9.23 6 193859 85 90434497
Mycobacterium fortuitum infection 14.76 9.23 6 193859 85 90434497
Blood glucose decreased 14.74 9.23 17 193848 23412 90411170
Cholelithiasis 14.71 9.23 60 193805 52446 90382136
Occult blood 14.67 9.23 16 193849 1295 90433287
Encephalopathy 14.66 9.23 158 193707 46286 90388296
Device related infection 14.66 9.23 100 193765 25686 90408896
Pancreatic atrophy 14.64 9.23 9 193856 320 90434262
Plantar fascial fibromatosis 14.64 9.23 7 193858 149 90434433
Toe amputation 14.59 9.23 20 193845 2049 90432533
Adrenal mass 14.52 9.23 15 193850 1140 90433442
Genital discomfort 14.52 9.23 6 193859 89 90434493
Metastases to bone 14.49 9.23 20 193845 25485 90409097
Restless legs syndrome 14.47 9.23 16 193849 22454 90412128
Respiratory arrest 14.46 9.23 31 193834 33280 90401302
Infection masked 14.43 9.23 5 193860 44 90434538
Pulmonary embolism 14.42 9.23 195 193670 130625 90303957
Dactylitis 14.38 9.23 28 193837 3845 90430737
Haematotoxicity 14.35 9.23 59 193806 12476 90422106
Reticulocytopenia 14.34 9.23 6 193859 92 90434490
Malignant neoplasm of conjunctiva 14.33 9.23 5 193860 45 90434537
Anal infection 14.28 9.23 6 193859 93 90434489
Human herpes virus 6 serology positive 14.28 9.23 6 193859 93 90434489
Haemochromatosis 14.26 9.23 12 193853 702 90433880
Hyperthyroidism 14.20 9.23 11 193854 18299 90416283
Infective chondritis 14.20 9.23 4 193861 16 90434566
Ureteral neoplasm 14.20 9.23 4 193861 16 90434566
Tongue neoplasm 14.16 9.23 6 193859 95 90434487
Pneumonia herpes viral 14.14 9.23 5 193860 47 90434535
Hypocalcaemia 14.13 9.23 45 193820 42323 90392259
Nasal polyps 14.13 9.23 3 193862 10877 90423705
Cerebral haemorrhage 14.12 9.23 124 193741 34398 90400184
Abdominal pain 14.11 9.23 697 193168 395024 90039558
Vasculitis 14.11 9.23 90 193775 22603 90411979
Cardiac disorder 14.11 9.23 68 193797 56804 90377778
Throat tightness 14.03 9.23 26 193839 29458 90405124
Pancreas transplant rejection 14.03 9.23 7 193858 164 90434418
Nephroblastoma 14.00 9.23 4 193861 17 90434565
Musculoskeletal disorder 13.95 9.23 87 193778 21682 90412900
Keratoacanthoma 13.93 9.23 11 193854 588 90433994
Lipohypertrophy 13.91 9.23 12 193853 727 90433855
Acute disseminated encephalomyelitis 13.89 9.23 8 193857 252 90434330
Upper respiratory tract infection 13.88 9.23 192 193673 128126 90306456
Endocarditis 13.88 9.23 40 193825 7073 90427509
Albuminuria 13.87 9.23 9 193856 352 90434230
Dermatofibrosarcoma protuberans 13.87 9.23 5 193860 50 90434532
Amniotic cavity infection 13.84 9.23 16 193849 1380 90433202
Psychomotor disadaptation syndrome 13.82 9.23 4 193861 18 90434564
Pneumothorax 13.82 9.23 79 193786 19088 90415494
Polymyositis 13.79 9.23 20 193845 2159 90432423
Ear pain 13.74 9.23 70 193795 57632 90376950
Phaeohyphomycosis 13.73 9.23 10 193855 473 90434109
Temperature regulation disorder 13.73 9.23 7 193858 14572 90420010
Muscle twitching 13.73 9.23 19 193846 24183 90410399
Cutaneous lymphoma 13.72 9.23 7 193858 172 90434410
Gingival swelling 13.71 9.23 32 193833 4981 90429601
Myasthenia gravis crisis 13.71 9.23 14 193851 1050 90433532
Necrosis 13.71 9.23 38 193827 6572 90428010
Clostridium difficile colitis 13.69 9.23 101 193764 26605 90407977
Immunodeficiency 13.68 9.23 47 193818 43187 90391395
Retrograde portal vein flow 13.64 9.23 4 193861 19 90434563
Quality of life decreased 13.64 9.23 56 193809 11833 90422749
Cytomegalovirus enteritis 13.63 9.23 9 193856 363 90434219
IgA nephropathy 13.60 9.23 13 193852 900 90433682
Liver function test increased 13.59 9.23 116 193749 84739 90349843
B-cell aplasia 13.55 9.23 8 193857 264 90434318
Gastrointestinal viral infection 13.51 9.23 16 193849 1417 90433165
CD8 lymphocytes increased 13.47 9.23 4 193861 20 90434562
Transfusion-related acute lung injury 13.47 9.23 7 193858 179 90434403
Hypocomplementaemia 13.44 9.23 8 193857 268 90434314
Disseminated toxoplasmosis 13.44 9.23 7 193858 180 90434402
Foreign body reaction 13.41 9.23 6 193859 109 90434473
Nasal ulcer 13.41 9.23 22 193843 2644 90431938
Splenic abscess 13.39 9.23 8 193857 270 90434312
Haemorrhagic cyst 13.39 9.23 8 193857 270 90434312
Human herpesvirus 6 infection reactivation 13.38 9.23 11 193854 623 90433959
Keratolysis exfoliativa acquired 13.38 9.23 3 193862 3 90434579
Vaginal cancer stage 0 13.38 9.23 3 193862 3 90434579
Cutaneous T-cell lymphoma refractory 13.38 9.23 3 193862 3 90434579
Intestinal ulcer perforation 13.38 9.23 3 193862 3 90434579
Water pollution 13.38 9.23 3 193862 3 90434579
Nail pterygium 13.38 9.23 3 193862 3 90434579
Removal of transplanted organ 13.38 9.23 3 193862 3 90434579
Kidney anastomosis 13.38 9.23 3 193862 3 90434579
Diffuse alveolar damage 13.37 9.23 14 193851 1081 90433501
Glomerulonephropathy 13.36 9.23 6 193859 110 90434472
Peripheral artery aneurysm 13.36 9.23 5 193860 56 90434526
Vertigo 13.27 9.23 91 193774 69720 90364862
Lymphocyte morphology abnormal 13.23 9.23 10 193855 501 90434081
Eye infection 13.21 9.23 63 193802 14191 90420391
Oral pain 13.17 9.23 117 193748 32566 90402016
Motor dysfunction 13.16 9.23 13 193852 19217 90415365
Vasogenic cerebral oedema 13.16 9.23 15 193850 1275 90433307
Arteriosclerosis 13.15 9.23 52 193813 10801 90423781
Vaccination site inflammation 13.13 9.23 5 193860 59 90434523
Joint destruction 13.09 9.23 6 193859 13281 90421301
Foot fracture 13.08 9.23 23 193842 26583 90407999
Musculoskeletal pain 13.07 9.23 273 193592 170978 90263604
Pyelonephritis acute 13.07 9.23 33 193832 5399 90429183
Malabsorption 13.03 9.23 32 193833 5146 90429436
Actinic keratosis 13.02 9.23 24 193841 3164 90431418
Nail dystrophy 12.89 9.23 15 193850 1303 90433279
Fear 12.87 9.23 10 193855 16612 90417970
Fluid balance positive 12.87 9.23 4 193861 24 90434558
Respiratory gas exchange disorder 12.85 9.23 9 193856 400 90434182
Primary adrenal insufficiency 12.85 9.23 8 193857 291 90434291
Heart rate irregular 12.84 9.23 20 193845 24248 90410334
Herpes simplex test positive 12.83 9.23 9 193856 401 90434181
Myoglobinuria 12.83 9.23 9 193856 401 90434181
Vitiligo 12.82 9.23 19 193846 2091 90432491
Cerebral venous thrombosis 12.79 9.23 20 193845 2308 90432274
Squamous cell carcinoma of the cervix 12.77 9.23 9 193856 404 90434178
Product dose omission in error 12.77 9.23 15 193850 20488 90414094
Secondary hypertension 12.75 9.23 8 193857 295 90434287
Renal cortical necrosis 12.75 9.23 8 193857 295 90434287
Osteoporotic fracture 12.70 9.23 30 193835 4706 90429876
Viral myocarditis 12.70 9.23 9 193856 408 90434174
Cytomegalovirus gastrointestinal infection 12.68 9.23 9 193856 409 90434173
Feeling abnormal 12.65 9.23 267 193598 166968 90267614
Eosinophilic myocarditis 12.64 9.23 11 193854 674 90433908
Vesicoureteric reflux 12.63 9.23 8 193857 300 90434282
Deep vein thrombosis 12.63 9.23 130 193735 91490 90343092
Vulvovaginal pruritus 12.62 9.23 27 193838 3966 90430616
Haemoglobinuria 12.61 9.23 8 193857 301 90434281
Concussion 12.61 9.23 4 193861 11087 90423495
Chimerism 12.59 9.23 4 193861 26 90434556
Mycobacterium haemophilum infection 12.55 9.23 7 193858 207 90434375
Device leakage 12.48 9.23 3 193862 9988 90424594
Tongue pigmentation 12.47 9.23 4 193861 27 90434555
Extubation 12.47 9.23 4 193861 27 90434555
Otitis media 12.43 9.23 34 193831 5836 90428746
Self-consciousness 12.42 9.23 5 193860 69 90434513
Vascular device infection 12.41 9.23 5 193860 11947 90422635
Perinephric collection 12.41 9.23 6 193859 131 90434451
Coccidioidomycosis 12.38 9.23 14 193851 1179 90433403
Superinfection bacterial 12.36 9.23 13 193852 1009 90433573
Pyogenic granuloma 12.19 9.23 8 193857 319 90434263
Treatment noncompliance 12.17 9.23 63 193802 51664 90382918
Sebaceous carcinoma 12.17 9.23 5 193860 73 90434509
Hepatitis C virus test 12.17 9.23 3 193862 6 90434576
Adenoviral encephalitis 12.17 9.23 3 193862 6 90434576
Lethargy 12.15 9.23 82 193783 63057 90371525
Hypotony of eye 12.14 9.23 7 193858 221 90434361
Diffuse alopecia 12.13 9.23 14 193851 1206 90433376
Arterial disorder 12.11 9.23 15 193850 1391 90433191
Bladder cancer recurrent 12.11 9.23 7 193858 222 90434360
Transurethral bladder resection 12.11 9.23 5 193860 74 90434508
Chronic myeloid leukaemia 12.09 9.23 21 193844 2643 90431939
Undifferentiated connective tissue disease 12.05 9.23 6 193859 140 90434442
Upper respiratory tract inflammation 12.04 9.23 21 193844 2651 90431931
Psychotic disorder 12.01 9.23 31 193834 31199 90403383
Pterygium 12.00 9.23 8 193857 328 90434254
Lymphopenia 11.99 9.23 87 193778 22794 90411788
Neuralgic amyotrophy 11.99 9.23 4 193861 31 90434551
Renal infarct 11.98 9.23 16 193849 1599 90432983
Gastric ulcer 11.97 9.23 100 193765 27348 90407234
Protein-losing gastroenteropathy 11.95 9.23 8 193857 330 90434252
Dialysis 11.94 9.23 52 193813 11277 90423305
Papule 11.93 9.23 41 193824 7961 90426621
Inappropriate schedule of product administration 11.93 9.23 412 193453 149521 90285061
Escherichia bacteraemia 11.92 9.23 33 193832 5702 90428880
Dysarthria 11.91 9.23 68 193797 54414 90380168
Depressed mood 11.91 9.23 61 193804 50161 90384421
Acute polyneuropathy 11.89 9.23 9 193856 452 90434130
Lacrimation disorder 11.85 9.23 3 193862 7 90434575
Anogenital warts 11.84 9.23 10 193855 588 90433994
Adjustment disorder 11.84 9.23 3 193862 9639 90424943
Cachexia 11.84 9.23 37 193828 6841 90427741
Cytomegalovirus gastritis 11.83 9.23 8 193857 336 90434246
Mycotic allergy 11.81 9.23 13 193852 1063 90433519
Renal haematoma 11.80 9.23 7 193858 233 90434349
Abscess 11.79 9.23 75 193790 18816 90415766
Cutaneous mucormycosis 11.75 9.23 5 193860 80 90434502
Stress cardiomyopathy 11.73 9.23 7 193858 13348 90421234
Periostitis 11.70 9.23 9 193856 463 90434119
Maculopathy 11.69 9.23 20 193845 2486 90432096
Pneumococcal sepsis 11.69 9.23 12 193853 906 90433676
Superinfection viral 11.67 9.23 4 193861 34 90434548
Toxic encephalopathy 11.63 9.23 43 193822 8656 90425926
Acute hepatitis C 11.59 9.23 5 193860 83 90434499
Transverse sinus thrombosis 11.57 9.23 10 193855 607 90433975
Small intestine adenocarcinoma 11.56 9.23 4 193861 35 90434547
Poor quality sleep 11.56 9.23 22 193843 24671 90409911
Miliaria 11.55 9.23 15 193850 1459 90433123
Diffuse large B-cell lymphoma stage IV 11.52 9.23 8 193857 351 90434231
Injection site induration 11.50 9.23 4 193861 10464 90424118
Sensory loss 11.50 9.23 13 193852 18062 90416520
Acid base balance abnormal 11.50 9.23 8 193857 352 90434230
Retinal scar 11.49 9.23 6 193859 155 90434427
Affect lability 11.48 9.23 13 193852 18050 90416532
Device breakage 11.46 9.23 8 193857 14036 90420546
Intervertebral disc degeneration 11.46 9.23 12 193853 17262 90417320
Faecaloma 11.44 9.23 4 193861 10427 90424155
Foetal growth restriction 11.41 9.23 45 193820 9335 90425247
Influenza 11.41 9.23 384 193481 138880 90295702
Eye infection staphylococcal 11.37 9.23 5 193860 87 90434495
Azotaemia 11.34 9.23 31 193834 5317 90429265
CSF protein increased 11.34 9.23 11 193854 775 90433807
Dermatosis 11.32 9.23 10 193855 625 90433957
Vascular pseudoaneurysm ruptured 11.32 9.23 5 193860 88 90434494
Gliosis 11.32 9.23 9 193856 486 90434096
Primary hypothyroidism 11.32 9.23 6 193859 160 90434422
Benign neoplasm of eye 11.31 9.23 3 193862 9 90434573
Pharyngeal necrosis 11.31 9.23 3 193862 9 90434573
Blood gonadotrophin increased 11.31 9.23 3 193862 9 90434573
Phospholipidosis 11.31 9.23 7 193858 252 90434330
Complication associated with device 11.30 9.23 15 193850 19434 90415148
Nosocomial infection 11.30 9.23 17 193848 1896 90432686
Acute promyelocytic leukaemia 11.30 9.23 13 193852 1116 90433466
Eye movement disorder 11.28 9.23 34 193831 6164 90428418
Thyroglossal cyst infection 11.27 9.23 4 193861 38 90434544
Antibiotic level above therapeutic 11.27 9.23 9 193856 489 90434093
Enzyme level increased 11.27 9.23 9 193856 489 90434093
Feeding disorder 11.23 9.23 70 193795 17442 90417140
Liver disorder 11.22 9.23 187 193678 121082 90313500
Gastric disorder 11.21 9.23 115 193750 33269 90401313
Skin infection 11.20 9.23 71 193794 17793 90416789
Limbal stem cell deficiency 11.18 9.23 4 193861 39 90434543
Post procedural urine leak 11.18 9.23 4 193861 39 90434543
Pigmentation disorder 11.17 9.23 33 193832 5916 90428666
Blood pressure fluctuation 11.15 9.23 66 193799 52347 90382235
Heart rate increased 11.14 9.23 172 193693 112730 90321852
Meibomian gland dysfunction 11.14 9.23 7 193858 259 90434323
Lower respiratory tract infection bacterial 11.13 9.23 9 193856 498 90434084
Cardiac valve vegetation 11.13 9.23 8 193857 371 90434211
Tanning 11.12 9.23 5 193860 92 90434490
Capillaritis 11.12 9.23 6 193859 166 90434416
Beta 2 microglobulin increased 11.09 9.23 7 193858 261 90434321
Drug dose omission by device 11.09 9.23 4 193861 10227 90424355
Removal of renal transplant 11.07 9.23 3 193862 10 90434572
Vulvovaginal human papilloma virus infection 11.07 9.23 3 193862 10 90434572
Panic attack 11.06 9.23 25 193840 26340 90408242
Hypomagnesaemia 11.05 9.23 39 193826 35549 90399033
Tumour lysis syndrome 11.04 9.23 5 193860 11147 90423435
Mycobacterium avium complex infection 11.03 9.23 26 193839 4072 90430510
Haemostasis 11.03 9.23 8 193857 376 90434206
Bronchospasm 11.02 9.23 17 193848 20692 90413890
Agranulocytosis 11.01 9.23 119 193746 34883 90399699
Leukodystrophy 11.00 9.23 4 193861 41 90434541
Paraesthesia oral 11.00 9.23 33 193832 31626 90402956
Blood iron increased 11.00 9.23 17 193848 1942 90432640
Renal artery stenosis 10.99 9.23 18 193847 2159 90432423
Injection site haemorrhage 10.97 9.23 28 193837 28290 90406292
Legionella infection 10.95 9.23 9 193856 510 90434072
Drug-induced liver injury 10.93 9.23 132 193733 90186 90344396
Glaucoma 10.93 9.23 79 193786 20676 90413906
Coordination abnormal 10.92 9.23 18 193847 21338 90413244
Biopsy muscle abnormal 10.92 9.23 4 193861 42 90434540
Vascular graft complication 10.92 9.23 4 193861 42 90434540
Therapeutic product ineffective 10.92 9.23 19 193846 2395 90432187
Pallor 10.90 9.23 37 193828 34128 90400454
Premature labour 10.90 9.23 57 193808 13319 90421263
Genital lesion 10.85 9.23 7 193858 271 90434311
Parainfluenzae viral bronchitis 10.85 9.23 3 193862 11 90434571
Marginal zone lymphoma 10.83 9.23 5 193860 98 90434484
Oral mucosal exfoliation 10.78 9.23 16 193849 1764 90432818
Intestinal atony 10.77 9.23 6 193859 177 90434405
Small intestinal obstruction 10.76 9.23 18 193847 21216 90413366
Mean cell haemoglobin increased 10.76 9.23 25 193840 3880 90430702
Lymphadenopathy mediastinal 10.69 9.23 22 193843 3145 90431437
Hypertrophic cardiomyopathy 10.69 9.23 18 193847 2210 90432372
Chronic hepatitis C 10.68 9.23 6 193859 180 90434402
Graft infection 10.67 9.23 7 193858 279 90434303
Sinonasal papilloma 10.67 9.23 4 193861 45 90434537
Ocular pemphigoid 10.65 9.23 5 193860 102 90434480
Arteriosclerotic retinopathy 10.65 9.23 3 193862 12 90434570
Hepatic haematoma 10.63 9.23 9 193856 531 90434051
Myocardial infarction 10.61 9.23 161 193704 105811 90328771
Pneumonia pneumococcal 10.61 9.23 20 193845 2682 90431900
Hepatitis fulminant 10.59 9.23 25 193840 3920 90430662
Creatinine renal clearance decreased 10.56 9.23 15 193850 18884 90415698
Complications of transplanted liver 10.55 9.23 8 193857 403 90434179
Induration 10.54 9.23 15 193850 1592 90432990
Skin burning sensation 10.53 9.23 75 193790 19536 90415046
CSF white blood cell count increased 10.52 9.23 4 193861 47 90434535
Bone lesion 10.50 9.23 34 193831 6403 90428179
Hypomania 10.49 9.23 3 193862 8894 90425688
Limbic encephalitis 10.48 9.23 7 193858 288 90434294
Haematochezia 10.45 9.23 99 193766 70814 90363768
Central venous pressure increased 10.43 9.23 5 193860 107 90434475
Corneal erosion 10.43 9.23 8 193857 410 90434172
Gastrointestinal necrosis 10.41 9.23 22 193843 3203 90431379
Cranial nerve disorder 10.40 9.23 10 193855 697 90433885
Delayed graft function 10.39 9.23 14 193851 1411 90433171
Acinetobacter bacteraemia 10.39 9.23 5 193860 108 90434474
Chronic inflammatory demyelinating polyradiculoneuropathy 10.38 9.23 12 193853 1035 90433547
Encephalitis autoimmune 10.37 9.23 17 193848 2041 90432541
Pre-existing condition improved 10.37 9.23 43 193822 9126 90425456
Periportal oedema 10.29 9.23 4 193861 50 90434532
Periorbital oedema 10.28 9.23 35 193830 6764 90427818
Ubiquinone decreased 10.28 9.23 3 193862 14 90434568
Cytomegalovirus gastrointestinal ulcer 10.28 9.23 3 193862 14 90434568
Oesophageal perforation 10.27 9.23 8 193857 419 90434163
Arterial occlusive disease 10.27 9.23 7 193858 12439 90422143
Anti-Muellerian hormone level decreased 10.26 9.23 5 193860 111 90434471
Roseolovirus test positive 10.22 9.23 5 193860 112 90434470
Angina pectoris 10.20 9.23 46 193819 39114 90395468
Hallucination 10.19 9.23 91 193774 65868 90368714
Antinuclear antibody positive 10.19 9.23 43 193822 9198 90425384
Pulmonary toxicity 10.19 9.23 6 193859 11525 90423057
Liver transplant 10.17 9.23 18 193847 2299 90432283
Acquired claw toe 10.16 9.23 6 193859 198 90434384
Cerebral aspergillosis 10.14 9.23 9 193856 566 90434016
Laparotomy 10.11 9.23 8 193857 429 90434153
Burkitt's lymphoma 10.11 9.23 3 193862 15 90434567
CD4/CD8 ratio increased 10.11 9.23 3 193862 15 90434567
Extrapyramidal disorder 10.07 9.23 12 193853 16291 90418291
Intravascular haemolysis 10.06 9.23 8 193857 432 90434150
Food allergy 10.02 9.23 25 193840 25453 90409129
Flank pain 10.02 9.23 16 193849 19206 90415376
Gestational hypertension 10.02 9.23 21 193844 3041 90431541
Myocarditis 10.02 9.23 57 193808 13749 90420833
Erythropoiesis abnormal 10.00 9.23 7 193858 311 90434271
Tuberculous pleurisy 9.98 9.23 8 193857 437 90434145
Ureteral necrosis 9.95 9.23 4 193861 55 90434527
PaO2/FiO2 ratio decreased 9.95 9.23 3 193862 16 90434566
Malaria 9.92 9.23 6 193859 207 90434375
CD8 lymphocytes decreased 9.90 9.23 6 193859 208 90434374
Drug level changed 9.90 9.23 6 193859 208 90434374
Infestation 9.89 9.23 4 193861 56 90434526
Photodermatosis 9.88 9.23 9 193856 586 90433996
Respiratory moniliasis 9.87 9.23 6 193859 209 90434373
Abnormal behaviour 9.87 9.23 21 193844 22607 90411975
Complication of device insertion 9.84 9.23 5 193860 10431 90424151
Plasmodium falciparum infection 9.82 9.23 4 193861 57 90434525
Candida pneumonia 9.82 9.23 6 193859 211 90434371
Large intestine perforation 9.80 9.23 44 193821 9668 90424914
Urine output decreased 9.79 9.23 53 193812 12550 90422032
Haematemesis 9.79 9.23 38 193827 33688 90400894
Endotracheal intubation 9.78 9.23 22 193843 3342 90431240
Aortic intramural haematoma 9.76 9.23 5 193860 124 90434458
Foetal exposure during pregnancy 9.74 9.23 53 193812 42922 90391660
Protein urine present 9.74 9.23 35 193830 6949 90427633
Epistaxis 9.70 9.23 126 193739 84999 90349583
Pustule 9.70 9.23 20 193845 2863 90431719
Culture stool positive 9.69 9.23 7 193858 327 90434255
Disseminated varicella zoster virus infection 9.69 9.23 8 193857 456 90434126
Rheumatoid factor negative 9.67 9.23 9 193856 602 90433980
Middle insomnia 9.65 9.23 13 193852 16738 90417844
Corneal perforation 9.65 9.23 9 193856 604 90433978
Eczema herpeticum 9.62 9.23 6 193859 219 90434363
Vulval cancer stage 0 9.62 9.23 5 193860 128 90434454
Renal cyst infection 9.62 9.23 5 193860 128 90434454
Remission not achieved 9.52 9.23 6 193859 223 90434359
Perineal disorder 9.51 9.23 3 193862 19 90434563
Splenectomy 9.50 9.23 9 193856 616 90433966
Laryngeal dyspnoea 9.50 9.23 6 193859 224 90434358
Renal artery thrombosis 9.48 9.23 5 193860 132 90434450
Bone density decreased 9.46 9.23 14 193851 17331 90417251
Dermatitis atopic 9.44 9.23 84 193781 23388 90411194
Ocular vascular disorder 9.44 9.23 9 193856 621 90433961
Intraocular pressure increased 9.43 9.23 35 193830 7058 90427524
Cardiac tamponade 9.42 9.23 30 193835 5602 90428980
Growth of eyelashes 9.40 9.23 6 193859 228 90434354
Lung squamous cell carcinoma metastatic 9.38 9.23 3 193862 20 90434562
Refractory cytopenia with multilineage dysplasia 9.38 9.23 5 193860 135 90434447
Pseudolymphoma 9.32 9.23 9 193856 631 90433951
Reaction to preservatives 9.29 9.23 6 193859 233 90434349
Urinary incontinence 9.27 9.23 45 193820 37521 90397061
Infectious mononucleosis 9.26 9.23 16 193849 2005 90432577
Acute myeloid leukaemia (in remission) 9.26 9.23 3 193862 21 90434561
Instillation site discomfort 9.26 9.23 3 193862 21 90434561
Toxoplasma serology positive 9.26 9.23 3 193862 21 90434561
Gastrointestinal oedema 9.24 9.23 14 193851 1572 90433010
Sinus congestion 9.23 9.23 29 193836 27395 90407187
Pneumonia necrotising 9.23 9.23 9 193856 638 90433944

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 2004.35 10.98 1318 151911 30988 42437118
Graft versus host disease 1490.90 10.98 788 152441 12137 42455969
Acute graft versus host disease 1374.77 10.98 645 152584 7570 42460536
Acute graft versus host disease in skin 1364.31 10.98 622 152607 6802 42461304
BK virus infection 1152.33 10.98 584 152645 8200 42459906
Chronic graft versus host disease 1136.15 10.98 514 152715 5511 42462595
Cytomegalovirus infection reactivation 998.77 10.98 576 152653 10602 42457504
Product use in unapproved indication 954.81 10.98 2069 151160 182387 42285719
Post transplant lymphoproliferative disorder 931.41 10.98 513 152716 8607 42459499
Graft versus host disease in gastrointestinal tract 920.08 10.98 423 152806 4720 42463386
Epstein-Barr virus infection 903.66 10.98 514 152715 9204 42458902
Posterior reversible encephalopathy syndrome 799.03 10.98 525 152704 12296 42455810
Kidney transplant rejection 777.19 10.98 448 152781 8235 42459871
Cystitis haemorrhagic 725.73 10.98 404 152825 6925 42461181
Nephropathy toxic 722.79 10.98 549 152680 16289 42451817
Acute graft versus host disease in intestine 716.27 10.98 328 152901 3623 42464483
Graft versus host disease in skin 673.25 10.98 343 152886 4869 42463237
Thrombotic microangiopathy 597.31 10.98 465 152764 14317 42453789
Transplant rejection 561.13 10.98 433 152796 13155 42454951
Fatigue 502.48 10.98 497 152732 435144 42032962
Drug ineffective 468.02 10.98 3855 149374 626342 41841764
Acute graft versus host disease in liver 443.30 10.98 190 153039 1768 42466338
Epstein-Barr virus associated lymphoproliferative disorder 430.88 10.98 199 153030 2244 42465862
Cytomegalovirus viraemia 420.43 10.98 327 152902 10050 42458056
Gingival hypertrophy 372.79 10.98 180 153049 2259 42465847
Dizziness 371.45 10.98 218 153011 249036 42219070
Adenovirus infection 367.23 10.98 255 152974 6554 42461552
Renal impairment 364.97 10.98 1044 152185 109184 42358922
Chronic graft versus host disease in skin 360.81 10.98 155 153074 1451 42466655
Polyomavirus-associated nephropathy 347.50 10.98 229 153000 5386 42462720
Fall 342.54 10.98 210 153019 234310 42233796
Drug abuse 338.29 10.98 8 153221 104763 42363343
Blood creatinine increased 335.59 10.98 1012 152217 108991 42359115
Complications of transplanted kidney 320.95 10.98 214 153015 5136 42462970
Completed suicide 309.02 10.98 8 153221 96457 42371649
Death 306.36 10.98 787 152442 470398 41997708
Aspergillus infection 300.03 10.98 326 152903 15511 42452595
Bronchopulmonary aspergillosis 293.89 10.98 356 152873 19073 42449033
Immunosuppressant drug level increased 286.10 10.98 231 152998 7500 42460606
Drug ineffective for unapproved indication 283.88 10.98 557 152672 45606 42422500
Heart transplant rejection 280.07 10.98 128 153101 1406 42466700
Epstein-Barr virus infection reactivation 266.02 10.98 147 153082 2480 42465626
Graft versus host disease in liver 265.83 10.98 126 153103 1513 42466593
Product dose omission issue 259.59 10.98 115 153114 154250 42313856
Chronic graft versus host disease in liver 258.01 10.98 96 153133 590 42467516
Pneumonia cytomegaloviral 257.09 10.98 169 153060 3957 42464149
Hypotension 256.82 10.98 330 152899 257301 42210805
Dyspnoea 250.19 10.98 790 152439 441831 42026275
Encephalitis cytomegalovirus 240.82 10.98 108 153121 1131 42466975
Epstein-Barr viraemia 237.06 10.98 130 153099 2159 42465947
Multiple organ dysfunction syndrome 232.11 10.98 822 152407 96213 42371893
Polyomavirus viraemia 229.98 10.98 124 153105 1988 42466118
Haemophagocytic lymphohistiocytosis 228.28 10.98 304 152925 17918 42450188
Therapy non-responder 226.87 10.98 555 152674 52804 42415302
Transplant failure 219.36 10.98 152 153077 3892 42464214
Somnolence 219.16 10.98 117 153112 140988 42327118
Liver transplant rejection 217.76 10.98 127 153102 2386 42465720
Hepatic function abnormal 212.50 10.98 530 152699 51037 42417069
Venoocclusive disease 212 10.98 147 153082 3768 42464338
Constipation 210.63 10.98 165 153064 162126 42305980
Transplant dysfunction 206.03 10.98 136 153093 3207 42464899
Asthenia 201.02 10.98 445 152784 280348 42187758
Mucosal inflammation 200.86 10.98 505 152724 48869 42419237
Disease recurrence 200.77 10.98 373 152856 29305 42438801
Treatment failure 200.13 10.98 586 152643 62038 42406068
Syncope 199.75 10.98 55 153174 99351 42368755
Pneumocystis jirovecii pneumonia 195.37 10.98 336 152893 24845 42443261
Off label use 194.35 10.98 3293 149936 635042 41833064
Viraemia 184.61 10.98 101 153128 1669 42466437
Cytomegalovirus test positive 181.25 10.98 139 153090 4180 42463926
Obliterative bronchiolitis 173.82 10.98 91 153138 1370 42466736
Anxiety 173.07 10.98 106 153123 118454 42349652
Intentional overdose 169.73 10.98 3 153226 51453 42416653
Immunosuppressant drug level decreased 168.22 10.98 96 153133 1728 42466378
Squamous cell carcinoma 166.33 10.98 219 153010 12763 42455343
Mucormycosis 165.82 10.98 164 153065 6979 42461127
Enterococcal infection 165.04 10.98 210 153019 11829 42456277
Drug eruption 163.63 10.98 296 152933 22779 42445327
Chronic allograft nephropathy 163.40 10.98 90 153139 1508 42466598
Overdose 159.45 10.98 90 153139 105174 42362932
Venoocclusive liver disease 159.42 10.98 191 153038 10111 42457995
Eye irritation 159.24 10.98 200 153029 11118 42456988
Viral haemorrhagic cystitis 158.81 10.98 93 153136 1761 42466345
JC virus infection 158.46 10.98 111 153118 2893 42465213
Kidney fibrosis 151.61 10.98 104 153125 2618 42465488
Proteinuria 149.40 10.98 284 152945 22699 42445407
Pyrexia 148.86 10.98 2110 151119 391932 42076174
Pseudomonas infection 147.21 10.98 230 152999 15693 42452413
Pain 143.58 10.98 429 152800 244419 42223687
Cystitis viral 141.07 10.98 75 153154 1167 42466939
Hyperhidrosis 140.54 10.98 75 153154 90437 42377669
Chronic graft versus host disease in intestine 139.05 10.98 55 153174 408 42467698
Chronic obstructive pulmonary disease 136.33 10.98 30 153199 63084 42405022
Lymphoproliferative disorder 135.64 10.98 105 153124 3202 42464904
Back pain 134.53 10.98 188 153041 141588 42326518
Malignant neoplasm progression 133.39 10.98 116 153113 108284 42359822
Pulmonary embolism 132.07 10.98 141 153088 119471 42348635
Chest pain 130.43 10.98 187 153042 139343 42328763
Human herpesvirus 6 infection 130.17 10.98 92 153137 2433 42465673
Hypogammaglobulinaemia 128.84 10.98 185 153044 11706 42456400
Drug resistance 128.63 10.98 340 152889 33908 42434198
Injection site pain 127.86 10.98 26 153203 57772 42410334
Decreased appetite 125.37 10.98 322 152907 192815 42275291
Oral administration complication 124.23 10.98 32 153197 36 42468070
Bradycardia 123.92 10.98 77 153152 85407 42382699
Coombs positive haemolytic anaemia 122.02 10.98 68 153161 1167 42466939
Fungal infection 121.20 10.98 238 152991 19484 42448622
Suicide attempt 119.72 10.98 13 153216 46087 42422019
Stomatitis 118.20 10.98 424 152805 49905 42418201
Dehydration 115.55 10.98 208 153021 141559 42326547
Lymphocele 115.40 10.98 71 153158 1476 42466630
Staphylococcal infection 115.21 10.98 347 152882 37296 42430810
Acute myeloid leukaemia recurrent 111.39 10.98 96 153133 3416 42464690
Bacterial infection 110.05 10.98 282 152947 27597 42440509
Engraftment syndrome 109.34 10.98 66 153163 1324 42466782
Herpes simplex 108.89 10.98 131 153098 6964 42461142
Cardiac failure congestive 108.49 10.98 89 153140 85513 42382593
Confusional state 108.29 10.98 280 152949 167317 42300789
Hospitalisation 107.67 10.98 67 153162 74263 42393843
Haemolysis 106.56 10.98 151 153078 9438 42458668
Complications of bone marrow transplant 105.64 10.98 38 153191 209 42467897
Graft versus host disease in lung 104.72 10.98 52 153177 696 42467410
Focal segmental glomerulosclerosis 104.72 10.98 81 153148 2467 42465639
Myocardial infarction 104.63 10.98 178 153051 123831 42344275
Depression 104.30 10.98 149 153080 111214 42356892
Hirsutism 104.09 10.98 39 153190 245 42467861
Atrial fibrillation 104.03 10.98 216 153013 139377 42328729
Asthma 103.73 10.98 47 153182 62267 42405839
Nausea 101.65 10.98 925 152304 395874 42072232
Klebsiella infection 101.03 10.98 161 153068 11171 42456935
Lung transplant rejection 98.96 10.98 56 153173 991 42467115
Encephalitis viral 98.65 10.98 64 153165 1464 42466642
Hypoglycaemia 98.31 10.98 46 153183 59808 42408298
Cytomegalovirus chorioretinitis 98.12 10.98 101 153128 4510 42463596
Rash 98 10.98 589 152640 276365 42191741
Progressive multifocal leukoencephalopathy 97.54 10.98 160 153069 11376 42456730
Kaposi's sarcoma 95.96 10.98 50 153179 745 42467361
Hyponatraemia 95.75 10.98 135 153094 101327 42366779
Malaise 94.94 10.98 416 152813 211740 42256366
Pancytopenia 94.74 10.98 736 152493 117007 42351099
Neuropathy peripheral 92.70 10.98 139 153090 101714 42366392
Suicidal ideation 92.40 10.98 29 153200 48132 42419974
Sedation 92.36 10.98 4 153225 30471 42437635
Renal transplant failure 92.19 10.98 61 153168 1444 42466662
Electrocardiogram QT prolonged 91.75 10.98 29 153200 47916 42420190
Renal tubular atrophy 91.63 10.98 60 153169 1395 42466711
Graft versus host disease in eye 90.72 10.98 37 153192 300 42467806
Vomiting 90.42 10.98 640 152589 289083 42179023
Wheezing 90.12 10.98 42 153187 54739 42413367
Stress 89.64 10.98 24 153205 44188 42423918
Graft loss 89.36 10.98 50 153179 865 42467241
Hypokalaemia 89.11 10.98 76 153153 71645 42396461
Blood bilirubin increased 87.58 10.98 342 152887 41910 42426196
Chronic graft versus host disease oral 86.87 10.98 38 153191 373 42467733
Agitation 86.40 10.98 63 153166 64251 42403855
Weight decreased 86.35 10.98 419 152810 207529 42260577
Cushingoid 85.87 10.98 82 153147 3340 42464766
Balance disorder 85.67 10.98 32 153197 47613 42420493
Intentional product misuse 85.30 10.98 59 153170 61841 42406265
Nocardiosis 84.89 10.98 99 153130 5091 42463015
Lymphadenitis 84.47 10.98 71 153158 2440 42465666
Bronchiolitis obliterans syndrome 83.22 10.98 34 153195 277 42467829
Lymphoid tissue hypoplasia 83.10 10.98 47 153182 831 42467275
Renal failure 82.80 10.98 835 152394 142891 42325215
Lactic acidosis 82.05 10.98 30 153199 45231 42422875
Septic shock 81.62 10.98 587 152642 91085 42377021
Candida infection 81.60 10.98 215 153014 21395 42446711
Peripheral swelling 81.36 10.98 124 153105 90146 42377960
Thymus hypoplasia 81.19 10.98 46 153183 816 42467290
Tenosynovitis 80.90 10.98 92 153137 4603 42463503
Cytomegalovirus colitis 78.98 10.98 84 153145 3897 42464209
Aggression 78.84 10.98 30 153199 44133 42423973
Rectal haemorrhage 78.61 10.98 40 153189 49566 42418540
Concomitant disease progression 78.54 10.98 68 153161 2435 42465671
Diffuse large B-cell lymphoma 78.42 10.98 130 153099 9324 42458782
International normalised ratio increased 77.60 10.98 38 153191 48130 42419976
Palpitations 77.50 10.98 43 153186 50754 42417352
Diarrhoea 77.09 10.98 1180 152049 459669 42008437
Aplasia pure red cell 76.91 10.98 111 153118 7055 42461051
Cutaneous T-cell lymphoma 76.68 10.98 61 153168 1937 42466169
Arthralgia 76.53 10.98 429 152800 204809 42263297
Serotonin syndrome 76.36 10.98 4 153225 25841 42442265
Psoriasis 75.79 10.98 361 152868 48243 42419863
Staphylococcal sepsis 75.35 10.98 142 153087 11272 42456834
Insomnia 75.24 10.98 199 153030 118054 42350052
Hepatitis E 74.69 10.98 73 153156 3061 42465045
Cerebrovascular accident 74.34 10.98 148 153081 97012 42371094
Aplastic anaemia 74.34 10.98 148 153081 12236 42455870
Neurotoxicity 74.23 10.98 220 153009 23431 42444675
Skin plaque 73.70 10.98 98 153131 5765 42462341
Cytokine release syndrome 73.46 10.98 34 153195 44493 42423613
Haemodialysis 73.21 10.98 132 153097 10128 42457978
Haemolytic uraemic syndrome 73.08 10.98 65 153164 2414 42465692
Enthesopathy 72.23 10.98 88 153141 4740 42463366
Hypertension 72.13 10.98 918 152311 166286 42301820
Engraft failure 71.32 10.98 37 153192 546 42467560
Pneumomediastinum 71.32 10.98 71 153158 3045 42465061
Bacteraemia 71.19 10.98 225 153004 24815 42443291
Disseminated aspergillosis 71.11 10.98 55 153174 1675 42466431
Cardiac arrest 71.05 10.98 182 153047 109138 42358968
Parvovirus B19 infection 71.00 10.98 55 153174 1679 42466427
Skin lesion 70.79 10.98 237 152992 26937 42441169
Mycobacterial infection 68.98 10.98 65 153164 2603 42465503
Alanine aminotransferase abnormal 68.96 10.98 87 153142 4857 42463249
Unevaluable event 68.78 10.98 19 153210 34269 42433837
Acute respiratory distress syndrome 68.42 10.98 251 152978 29857 42438249
Lymphopenia 68.07 10.98 201 153028 21362 42446744
Thrombotic thrombocytopenic purpura 68.04 10.98 76 153153 3728 42464378
Squamous cell carcinoma of skin 66.89 10.98 144 153085 12582 42455524
Blood glucose increased 66.64 10.98 101 153128 73598 42394508
Erythrodermic psoriasis 66.48 10.98 44 153185 1042 42467064
Growth retardation 66.25 10.98 61 153168 2371 42465735
Cardio-respiratory arrest 65.93 10.98 68 153161 58568 42409538
Weight increased 65.49 10.98 186 153043 107797 42360309
Nightmare 65.07 10.98 7 153222 25005 42443101
Complications of transplanted heart 64.72 10.98 29 153200 303 42467803
Renal tubular necrosis 64.67 10.98 178 153051 18176 42449930
Loss of consciousness 64.55 10.98 148 153081 92206 42375900
Tachycardia 64.38 10.98 170 153059 100917 42367189
Chest discomfort 63.70 10.98 81 153148 63535 42404571
Myopathy 63.68 10.98 148 153081 13613 42454493
Drug reaction with eosinophilia and systemic symptoms 63.63 10.98 36 153193 42039 42426067
Alveolar proteinosis 63.53 10.98 37 153192 693 42467413
Vein rupture 63.19 10.98 41 153188 938 42467168
Pneumonia fungal 63.14 10.98 116 153113 9030 42459076
Hepatitis C 63.12 10.98 123 153106 10010 42458096
American trypanosomiasis 62.78 10.98 29 153200 327 42467779
Urinary retention 62.59 10.98 37 153192 42177 42425929
Papilloma viral infection 61.27 10.98 36 153193 686 42467420
Sepsis 60.95 10.98 1031 152198 198303 42269803
Mycobacterium chelonae infection 60.91 10.98 43 153186 1135 42466971
Deep vein thrombosis 60.80 10.98 115 153114 76842 42391264
Toxicity to various agents 60.76 10.98 529 152700 228607 42239499
Gastrooesophageal reflux disease 60.60 10.98 44 153185 44979 42423127
Heart rate decreased 60.10 10.98 28 153201 36504 42431602
Gastroenteritis astroviral 60.00 10.98 19 153210 65 42468041
Flushing 59.96 10.98 29 153200 36999 42431107
Escherichia infection 59.96 10.98 129 153100 11267 42456839
Erectile dysfunction 59.91 10.98 9 153220 24904 42443202
Viral test positive 59.73 10.98 25 153204 218 42467888
Scleroderma 59.25 10.98 50 153179 1728 42466378
Hypoaesthesia 58.94 10.98 104 153125 71359 42396747
Sleep disorder 58.48 10.98 52 153177 48043 42420063
Nephrotic syndrome 58.22 10.98 109 153120 8609 42459497
Incorrect route of product administration 57.94 10.98 9 153220 24296 42443810
Rebound effect 57.92 10.98 99 153130 7280 42460826
Enterocolitis viral 57.57 10.98 30 153199 447 42467659
Inappropriate schedule of product administration 57.55 10.98 166 153063 95736 42372370
Pneumatosis intestinalis 57.54 10.98 78 153151 4674 42463432
Coronary artery disease 57.40 10.98 65 153164 53655 42414451
Abdominal discomfort 57.24 10.98 115 153114 75140 42392966
Delirium 56.71 10.98 63 153166 52456 42415650
Mycobacterium haemophilum infection 56.20 10.98 29 153200 423 42467683
Joint swelling 56.09 10.98 99 153130 67923 42400183
Cerebral toxoplasmosis 55.94 10.98 52 153177 2046 42466060
Cardiac disorder 55.86 10.98 56 153173 48876 42419230
Full blood count abnormal 55.52 10.98 19 153210 29857 42438249
Chronic graft versus host disease in eye 55.47 10.98 25 153204 265 42467841
Bacillary angiomatosis 55.30 10.98 23 153206 197 42467909
Anaemia 55.17 10.98 694 152535 279584 42188522
Chorioretinopathy 55.06 10.98 45 153184 1486 42466620
Bacterial sepsis 54.93 10.98 90 153139 6392 42461714
Glomerulonephritis 54.22 10.98 56 153173 2510 42465596
End stage renal disease 53.85 10.98 156 153073 16402 42451704
Enterobacter infection 53.70 10.98 60 153169 2944 42465162
Varicella zoster virus infection 53.59 10.98 56 153173 2545 42465561
Dysgeusia 53.52 10.98 28 153201 34161 42433945
Alternaria infection 53.40 10.98 31 153198 577 42467529
Atypical mycobacterial infection 53.06 10.98 42 153187 1324 42466782
Nasopharyngitis 52.92 10.98 142 153087 83854 42384252
Ventricular fibrillation 52.87 10.98 21 153208 30102 42438004
Feeling abnormal 52.77 10.98 107 153122 69679 42398427
Glomerulonephritis membranous 52.69 10.98 43 153186 1417 42466689
C-reactive protein abnormal 52.40 10.98 108 153121 9153 42458953
Cryptococcosis 52.10 10.98 61 153168 3150 42464956
Infection reactivation 52.09 10.98 51 153178 2143 42465963
Nephropathy 51.99 10.98 91 153138 6820 42461286
Thrombosis 51.85 10.98 105 153124 68406 42399700
Lung infiltration 51.62 10.98 138 153091 13851 42454255
Tongue disorder 51.49 10.98 79 153150 5304 42462802
Generalised oedema 51.34 10.98 146 153083 15190 42452916
Enterococcal sepsis 51.32 10.98 49 153180 1995 42466111
Hypertrichosis 51.23 10.98 30 153199 568 42467538
Drug hypersensitivity 50.63 10.98 185 153044 99204 42368902
General physical health deterioration 50.61 10.98 327 152902 150919 42317187
Osteonecrosis of jaw 50.41 10.98 5 153224 19044 42449062
Basal cell carcinoma 50.38 10.98 188 153041 22545 42445561
Systemic mycosis 50.27 10.98 52 153177 2335 42465771
Memory impairment 50.22 10.98 64 153165 50158 42417948
Oxygen saturation decreased 49.93 10.98 98 153131 64589 42403517
Respiratory depression 49.81 10.98 5 153224 18863 42449243
Stenotrophomonas infection 49.80 10.98 64 153165 3640 42464466
Ventricular tachycardia 49.79 10.98 23 153206 30137 42437969
Human herpesvirus 8 infection 49.68 10.98 42 153187 1455 42466651
Human herpesvirus 6 infection reactivation 49.68 10.98 27 153202 440 42467666
Acute myocardial infarction 49.47 10.98 83 153146 58082 42410024
Injection site erythema 49.24 10.98 7 153222 20188 42447918
Nephrectomy 48.97 10.98 34 153195 873 42467233
Pneumonia aspiration 48.86 10.98 65 153164 50013 42418093
Drug level increased 48.66 10.98 205 153024 25995 42442111
Adenoviral haemorrhagic cystitis 48.53 10.98 28 153201 515 42467591
Short stature 48.37 10.98 26 153203 414 42467692
Pyogenic granuloma 48.31 10.98 23 153206 279 42467827
Transient ischaemic attack 48.03 10.98 31 153198 33708 42434398
Glomerulosclerosis 47.75 10.98 33 153196 841 42467265
Prostate cancer 47.71 10.98 54 153175 44589 42423517
Abdominal distension 47.70 10.98 118 153111 71617 42396489
Hypophosphataemia 47.20 10.98 9 153220 20936 42447170
Gait disturbance 46.96 10.98 187 153042 97813 42370293
Fusarium infection 46.90 10.98 42 153187 1574 42466532
Lactobacillus infection 46.51 10.98 24 153205 350 42467756
Papilloma 46.39 10.98 24 153205 352 42467754
Epstein-Barr virus associated lymphoma 46.25 10.98 35 153194 1031 42467075
Poikiloderma 45.98 10.98 23 153206 313 42467793
Diabetic ketoacidosis 45.60 10.98 12 153217 22355 42445751
Spermatozoa progressive motility decreased 45.49 10.98 20 153209 199 42467907
Hallucination 45.36 10.98 86 153143 57421 42410685
Leukaemia recurrent 45.27 10.98 44 153185 1832 42466274
Encephalitis 45.15 10.98 101 153128 9057 42459049
Drug withdrawal syndrome 45.01 10.98 11 153218 21538 42446568
Adverse drug reaction 44.88 10.98 41 153188 37393 42430713
Opportunistic infection 44.70 10.98 45 153184 1956 42466150
Complications of transplant surgery 44.50 10.98 26 153203 490 42467616
Tularaemia 44.49 10.98 19 153210 175 42467931
Vertigo 44.38 10.98 35 153194 34312 42433794
Human polyomavirus infection 44.16 10.98 37 153192 1266 42466840
Appendicitis 44.09 10.98 10 153219 20603 42447503
Actinic keratosis 44.04 10.98 72 153157 5104 42463002
Swollen tongue 44.03 10.98 11 153218 21220 42446886
Bone marrow failure 43.98 10.98 235 152994 32858 42435248
Urticaria 43.96 10.98 433 152796 73603 42394503
Stem cell transplant 43.75 10.98 51 153178 2621 42465485
Respiratory failure 43.70 10.98 675 152554 127457 42340649
Osteonecrosis 43.67 10.98 141 153088 15724 42452382
Human herpesvirus 6 encephalitis 43.35 10.98 27 153202 574 42467532
Tumour lysis syndrome 43.33 10.98 13 153216 22218 42445888
Ureteric stenosis 43.31 10.98 36 153193 1218 42466888
Hepatic fibrosis 43.13 10.98 69 153160 4803 42463303
Autoimmune haemolytic anaemia 43.09 10.98 75 153154 5596 42462510
Haptoglobin decreased 43.08 10.98 29 153200 707 42467399
Rhabdomyolysis 42.83 10.98 449 152780 77570 42390536
Haemosiderosis 42.75 10.98 22 153207 319 42467787
Sleep disorder due to a general medical condition 42.67 10.98 6 153223 17447 42450659
Orthostatic hypotension 42.29 10.98 29 153200 30541 42437565
Scedosporium infection 42.29 10.98 39 153190 1519 42466587
Head injury 42.04 10.98 11 153218 20571 42447535
Urine output decreased 41.88 10.98 109 153120 10764 42457342
Foetal exposure during pregnancy 41.64 10.98 66 153163 47245 42420861
Mycoplasma infection 41.60 10.98 27 153202 618 42467488
Venous injury 41.57 10.98 22 153207 339 42467767
Malacoplakia 41.56 10.98 31 153198 893 42467213
Contusion 41.47 10.98 54 153175 41931 42426175
Troponin increased 41.27 10.98 9 153220 19053 42449053
Cytomegalovirus syndrome 41.24 10.98 16 153213 112 42467994
Trichophytic granuloma 40.93 10.98 13 153216 45 42468061
Lymphocytic infiltration 40.91 10.98 31 153198 915 42467191
Herpes virus infection 40.81 10.98 58 153171 3634 42464472
Psoriatic arthropathy 40.78 10.98 188 153041 24779 42443327
Serum sickness 40.73 10.98 45 153184 2180 42465926
Meningoencephalitis herpetic 40.61 10.98 32 153197 1002 42467104
Unresponsive to stimuli 40.58 10.98 32 153197 31371 42436735
Gastroenteritis rotavirus 40.53 10.98 21 153208 309 42467797
Brain stem syndrome 40.41 10.98 27 153202 650 42467456
Blood pressure decreased 40.33 10.98 94 153135 58238 42409868
Therapeutic response decreased 40.14 10.98 249 152980 36763 42431343
Pruritus 39.92 10.98 460 152769 188311 42279795
Paraesthesia 39.92 10.98 133 153096 73326 42394780
Therapy interrupted 39.90 10.98 15 153214 22235 42445871
Smooth muscle cell neoplasm 39.87 10.98 20 153209 274 42467832
Microangiopathic haemolytic anaemia 39.76 10.98 33 153196 1114 42466992
Brain abscess 39.75 10.98 62 153167 4222 42463884
Haematochezia 39.73 10.98 95 153134 58341 42409765
Steroid diabetes 39.48 10.98 50 153179 2802 42465304
Serum ferritin increased 39.46 10.98 83 153146 7136 42460970
Red blood cell schistocytes present 39.37 10.98 21 153208 329 42467777
Toxoplasmosis 39.36 10.98 38 153191 1569 42466537
Chimerism 39.30 10.98 19 153210 239 42467867
Hyperplasia 39.21 10.98 27 153202 684 42467422
Accidental overdose 39.02 10.98 27 153202 28303 42439803
Prostatic specific antigen increased 38.72 10.98 7 153222 16918 42451188
Blood beta-D-glucan increased 38.71 10.98 24 153205 506 42467600
Hypocalcaemia 38.67 10.98 31 153198 30142 42437964
Renal disorder 38.65 10.98 206 153023 28774 42439332
Blood stem cell transplant failure 38.61 10.98 23 153206 450 42467656
Lymphadenopathy 38.43 10.98 228 153001 33137 42434969
White blood cell count decreased 38.29 10.98 236 152993 110160 42357946
Disseminated tuberculosis 38.29 10.98 49 153180 2775 42465331
Productive cough 38.19 10.98 80 153149 51487 42416619
Arteriosclerosis coronary artery 38.11 10.98 10 153219 18667 42449439
Synovitis 38.11 10.98 133 153096 15434 42452672
Reticulocyte count increased 38.07 10.98 28 153201 789 42467317
Dyskinesia 37.99 10.98 22 153207 25368 42442738
Wrong technique in product usage process 37.98 10.98 59 153170 42576 42425530
Eye pain 37.87 10.98 141 153088 16889 42451217
Treatment noncompliance 37.67 10.98 48 153181 37624 42430482
Dry skin 37.50 10.98 73 153156 48265 42419841
Pseudomonal sepsis 37.37 10.98 60 153169 4189 42463917
Instillation site pain 37.36 10.98 14 153215 88 42468018
Complications of transplanted lung 37.29 10.98 20 153209 317 42467789
Blood lactate dehydrogenase increased 37.28 10.98 189 153040 25892 42442214
Porokeratosis 37.17 10.98 15 153214 118 42467988
Drug dependence 37.15 10.98 30 153199 29064 42439042
Skin papilloma 37.13 10.98 48 153181 2746 42465360
Cardiogenic shock 37.12 10.98 44 153185 35596 42432510
Human ehrlichiosis 37.09 10.98 23 153206 485 42467621
Biopsy kidney abnormal 37.06 10.98 15 153214 119 42467987
Disseminated mycobacterium avium complex infection 37.05 10.98 18 153211 229 42467877
Immunosuppression 37.04 10.98 89 153140 8364 42459742
Candida sepsis 36.97 10.98 35 153194 1410 42466696
Hot flush 36.96 10.98 17 153212 22334 42445772
Abdominal pain upper 36.86 10.98 162 153067 82447 42385659
Dysphonia 36.75 10.98 29 153200 28421 42439685
Pneumonia bacterial 36.64 10.98 132 153097 15560 42452546
Blood pressure fluctuation 36.59 10.98 26 153203 26882 42441224
Drug level changed 36.55 10.98 21 153208 383 42467723
Benign prostatic hyperplasia 36.42 10.98 15 153214 21037 42447069
Sebaceous hyperplasia 36.22 10.98 15 153214 127 42467979
Hypersomnia 35.80 10.98 5 153224 14613 42453493
Nephrolithiasis 35.73 10.98 48 153181 36782 42431324
Epstein-Barr virus antibody positive 35.71 10.98 19 153210 296 42467810
Presyncope 35.54 10.98 18 153211 22369 42445737
Pulmonary nocardiosis 35.53 10.98 38 153191 1774 42466332
Tinnitus 35.52 10.98 31 153198 28907 42439199
Encephalitis fungal 35.44 10.98 17 153212 210 42467896
Infection 35.43 10.98 583 152646 111485 42356621
Acinetobacter infection 35.25 10.98 35 153194 1496 42466610
Plasmodium falciparum infection 35.20 10.98 13 153216 78 42468028
Blindness cortical 35.14 10.98 22 153207 472 42467634
Acute lymphocytic leukaemia recurrent 35.06 10.98 54 153175 3637 42464469
Chronic myeloid leukaemia 34.99 10.98 44 153185 2448 42465658
Hypersensitivity 34.91 10.98 406 152823 71964 42396142
Sleep apnoea syndrome 34.87 10.98 17 153212 21591 42446515
Lower respiratory tract infection 34.85 10.98 59 153170 41147 42426959
Osmotic demyelination syndrome 34.84 10.98 29 153200 983 42467123
Hemianopia 34.80 10.98 28 153201 904 42467202
Leukopenia 34.59 10.98 416 152813 74330 42393776
Laparotomy 34.51 10.98 19 153210 318 42467788
Hepatic enzyme increased 34.47 10.98 282 152947 45502 42422604
Viral infection 34.32 10.98 166 153063 22317 42445789
Renal lymphocele 34.13 10.98 12 153217 61 42468045
Cough 33.87 10.98 444 152785 177659 42290447
Lethargy 33.68 10.98 74 153155 46816 42421290
Neutrophil count decreased 33.65 10.98 116 153113 63299 42404807
Myopathy toxic 33.64 10.98 25 153204 716 42467390
Iron overload 33.34 10.98 34 153195 1501 42466605
Intentional self-injury 33.28 10.98 7 153222 15195 42452911
Rhinovirus infection 33.17 10.98 73 153156 6475 42461631
Injection site papule 33.10 10.98 19 153210 346 42467760
Hepatitis B 33.07 10.98 74 153155 6637 42461469
Skin infection 33.07 10.98 91 153138 9289 42458817
Respiratory arrest 33.05 10.98 32 153197 28392 42439714
Dermatitis exfoliative generalised 33.05 10.98 68 153161 5756 42462350
Phaeohyphomycosis 32.84 10.98 30 153199 1154 42466952
Eosinophilia 32.81 10.98 42 153187 32857 42435249
Endoscopic retrograde cholangiopancreatography 32.60 10.98 8 153221 6 42468100
Oliguria 32.49 10.98 90 153139 9223 42458883
Klebsiella sepsis 32.20 10.98 44 153185 2657 42465449
Flatulence 32.03 10.98 26 153203 25126 42442980
Heart rate irregular 31.99 10.98 9 153220 16041 42452065
Herpes simplex pneumonia 31.95 10.98 17 153212 265 42467841
Skin mass 31.89 10.98 60 153169 4756 42463350
Glomerulonephropathy 31.65 10.98 16 153213 223 42467883
Inflammatory myofibroblastic tumour 31.61 10.98 14 153215 142 42467964
Behcet's syndrome 31.54 10.98 8 153221 8 42468098
Skin necrosis 31.54 10.98 70 153159 6244 42461862
Hepatitis B reactivation 31.52 10.98 58 153171 4520 42463586
Laboratory test abnormal 31.51 10.98 22 153207 22956 42445150
Blood urea increased 31.51 10.98 214 153015 32579 42435527
Small intestinal obstruction 31.44 10.98 11 153218 17050 42451056
Escherichia sepsis 31.32 10.98 66 153163 5681 42462425
Systemic candida 31.24 10.98 63 153166 5256 42462850
Pulmonary haemorrhage 31.11 10.98 101 153128 11296 42456810
Life support 31.02 10.98 14 153215 149 42467957
Fungal sepsis 30.89 10.98 28 153201 1066 42467040
Intentional product use issue 30.77 10.98 143 153086 71690 42396416
Dyspepsia 30.75 10.98 64 153165 41288 42426818
Tremor 30.68 10.98 213 153016 96716 42371390
Restlessness 30.58 10.98 36 153193 29213 42438893
Pustular psoriasis 30.55 10.98 38 153191 2091 42466015
Corneal endotheliitis 30.50 10.98 11 153218 61 42468045
Abnormal behaviour 30.50 10.98 30 153199 26421 42441685
Passenger lymphocyte syndrome 30.46 10.98 12 153217 88 42468018
Musculoskeletal stiffness 30.42 10.98 106 153123 57659 42410447
Clostridium difficile colitis 30.37 10.98 154 153075 21098 42447008
IgA nephropathy 30.33 10.98 40 153189 2334 42465772
Idiopathic pneumonia syndrome 30.32 10.98 20 153209 471 42467635
Sinus bradycardia 30.22 10.98 8 153221 14845 42453261
Biphasic mesothelioma 30.06 10.98 11 153218 64 42468042
Frequent bowel movements 30.02 10.98 20 153209 21387 42446719
Dystonia 29.89 10.98 5 153224 12785 42455321
Chromophobe renal cell carcinoma 29.78 10.98 11 153218 66 42468040
Hepatic cancer recurrent 29.74 10.98 17 153212 307 42467799
Renal vessel disorder 29.68 10.98 15 153214 209 42467897
Renal transplant 29.66 10.98 40 153189 2385 42465721
Ureteric dilatation 29.55 10.98 15 153214 211 42467895
Anuria 29.52 10.98 100 153129 11432 42456674
Retinopathy haemorrhagic 29.51 10.98 11 153218 68 42468038
Intracranial pressure increased 29.43 10.98 57 153172 4617 42463489
Central nervous system fungal infection 29.31 10.98 19 153210 434 42467672
Lip swelling 29.24 10.98 16 153213 19037 42449069
Rotavirus infection 29.20 10.98 20 153209 502 42467604
Apoptosis 29.17 10.98 21 153208 572 42467534
Paroxysmal nocturnal haemoglobinuria 29.16 10.98 13 153216 134 42467972
Biliary hamartoma 29.01 10.98 8 153221 14 42468092
Device related infection 29.01 10.98 147 153082 20132 42447974
Removal of renal transplant 28.83 10.98 9 153220 29 42468077
Cytomegalovirus hepatitis 28.83 10.98 20 153209 513 42467593
Bronchitis 28.82 10.98 81 153148 47120 42420986
Swelling face 28.72 10.98 34 153195 27520 42440586
Dysphagia 28.70 10.98 149 153080 72570 42395536
Pallor 28.68 10.98 37 153192 28849 42439257
Blood potassium decreased 28.65 10.98 19 153210 20365 42447741
Osteopenia 28.48 10.98 67 153162 6211 42461895
Atypical mycobacterial pneumonia 28.46 10.98 15 153214 229 42467877
Plasmacytoma 28.44 10.98 54 153175 4310 42463796
Spinal cord injury cervical 28.43 10.98 16 153213 280 42467826
Hepatosplenomegaly 28.34 10.98 56 153173 4604 42463502
Oedema peripheral 28.20 10.98 333 152896 135743 42332363
Prescribed overdose 28.20 10.98 6 153223 12921 42455185
Acute disseminated encephalomyelitis 28.19 10.98 13 153216 146 42467960
Osteoporosis 27.96 10.98 117 153112 14789 42453317
Road traffic accident 27.92 10.98 17 153212 19076 42449030
Skin laceration 27.80 10.98 8 153221 14050 42454056
Aneurysm 27.77 10.98 36 153193 2065 42466041
Mycobacterium kansasii infection 27.65 10.98 17 153212 353 42467753
T-cell type acute leukaemia 27.51 10.98 14 153215 198 42467908
Central nervous system viral infection 27.50 10.98 13 153216 155 42467951
Pulmonary tuberculosis 27.49 10.98 61 153168 5440 42462666
Toxic leukoencephalopathy 27.48 10.98 22 153207 705 42467401
Complications of transplanted liver 27.46 10.98 16 153213 300 42467806
Schizophrenia 27.32 10.98 3 153226 10547 42457559
Cardiac failure 27.25 10.98 249 152980 106607 42361499
Respiratory tract infection fungal 27.22 10.98 23 153206 796 42467310
Heart rate increased 27.19 10.98 99 153130 53156 42414950
Herpes zoster meningoencephalitis 27.03 10.98 19 153210 498 42467608
Necrosis 26.99 10.98 68 153161 6583 42461523
Dry mouth 26.97 10.98 65 153164 39814 42428292
Malabsorption 26.95 10.98 41 153188 2732 42465374
Upper gastrointestinal haemorrhage 26.92 10.98 42 153187 30257 42437849
Legionella infection 26.85 10.98 20 153209 575 42467531
Drug level fluctuating 26.77 10.98 21 153208 653 42467453
Pyelonephritis chronic 26.76 10.98 9 153220 39 42468067
Swelling 26.74 10.98 104 153125 54781 42413325
Interleukin-2 receptor increased 26.72 10.98 13 153216 166 42467940
Abdominal pain 26.71 10.98 503 152726 189968 42278138
Pneumonia adenoviral 26.70 10.98 17 153212 376 42467730
Transaminases increased 26.64 10.98 206 153023 32679 42435427
Epstein-Barr virus test positive 26.50 10.98 21 153208 663 42467443
Fungal endocarditis 26.49 10.98 18 153211 446 42467660
Dyspnoea exertional 26.42 10.98 92 153137 50056 42418050
Central nervous system lesion 26.42 10.98 75 153154 7795 42460311
Extrapyramidal disorder 26.35 10.98 13 153216 16399 42451707
Salivary hypersecretion 26.20 10.98 4 153225 10939 42457167
Diffuse alveolar damage 26.15 10.98 39 153190 2553 42465553
Device issue 26.14 10.98 8 153221 13501 42454605
Mass excision 26.06 10.98 9 153220 43 42468063
Pneumocystis jirovecii infection 26.00 10.98 41 153188 2819 42465287
Leukoencephalopathy 25.97 10.98 56 153173 4898 42463208
Disturbance in attention 25.96 10.98 42 153187 29824 42438282
Monkeypox 25.89 10.98 17 153212 397 42467709
Diffuse large B-cell lymphoma stage IV 25.88 10.98 19 153210 534 42467572
Hypertensive encephalopathy 25.87 10.98 18 153211 464 42467642
Self-consciousness 25.85 10.98 12 153217 137 42467969
Lepromatous leprosy 25.78 10.98 10 153219 70 42468036
Bowen's disease 25.69 10.98 12 153217 139 42467967
Ureaplasma infection 25.66 10.98 20 153209 616 42467490
Cat scratch disease 25.61 10.98 16 153213 342 42467764
Skin injury 25.60 10.98 39 153190 2602 42465504
Acute graft versus host disease oral 25.57 10.98 8 153221 26 42468080
Reticulocytosis 25.57 10.98 15 153214 285 42467821
Cutaneous sporotrichosis 25.56 10.98 9 153220 46 42468060
Philadelphia positive chronic myeloid leukaemia 25.54 10.98 12 153217 141 42467965
Tendonitis 25.50 10.98 86 153143 9808 42458298
Red blood cell sedimentation rate 25.44 10.98 25 153204 1055 42467051
Haemorrhoids 25.32 10.98 15 153214 17082 42451024
Panniculitis 25.20 10.98 35 153194 2146 42465960
Pneumonia pseudomonal 25.17 10.98 55 153174 4854 42463252
Varicella 25.16 10.98 34 153195 2031 42466075
Therapy partial responder 25.13 10.98 140 153089 19881 42448225
Sweat gland tumour 25.13 10.98 17 153212 418 42467688
Therapy cessation 24.99 10.98 22 153207 20428 42447678
Cytomegalovirus enteritis 24.98 10.98 20 153209 641 42467465
Injury 24.94 10.98 26 153203 22290 42445816
Migraine with aura 24.93 10.98 23 153206 896 42467210
Activated partial thromboplastin time prolonged 24.93 10.98 13 153216 15890 42452216
Adverse event 24.82 10.98 29 153200 23611 42444495
CSF protein increased 24.78 10.98 22 153207 815 42467291
Intestinal obstruction 24.75 10.98 37 153192 27121 42440985
Laser therapy 24.74 10.98 6 153223 4 42468102
Subdural haematoma 24.71 10.98 28 153201 23110 42444996
Impaired quality of life 24.69 10.98 10 153219 14167 42453939
Erythema infectiosum 24.68 10.98 12 153217 153 42467953
Vanishing bile duct syndrome 24.64 10.98 32 153197 1839 42466267
Incisional drainage 24.54 10.98 11 153218 115 42467991
Aplasia 24.54 10.98 54 153175 4789 42463317
Cryptococcal cutaneous infection 24.41 10.98 12 153217 157 42467949
Pigmentation disorder 24.40 10.98 42 153187 3106 42465000
Post transplant distal limb syndrome 24.37 10.98 17 153212 440 42467666
Alanine aminotransferase increased 24.37 10.98 450 152779 87956 42380150
Rheumatoid arthritis 24.33 10.98 75 153154 42365 42425741
Glomerulonephritis membranoproliferative 24.33 10.98 18 153211 512 42467594
Sinus tachycardia 24.30 10.98 23 153206 20630 42447476
Foreign body sensation in eyes 24.18 10.98 23 153206 932 42467174
Keratitis 24.16 10.98 31 153198 1760 42466346
Neuroendocrine carcinoma of the skin 24.14 10.98 23 153206 934 42467172
Medication error 24.07 10.98 52 153177 33102 42435004
Mechanical ventilation 24.04 10.98 35 153194 2242 42465864
Irritability 24.04 10.98 40 153189 28088 42440018
Hepatotoxicity 24.04 10.98 164 153065 25003 42443103
Pain in jaw 24.03 10.98 11 153218 14491 42453615
Pathogen resistance 23.97 10.98 93 153136 11357 42456749
Empyema 23.95 10.98 49 153180 4131 42463975
Trichophytosis 23.84 10.98 16 153213 388 42467718
Impaired work ability 23.69 10.98 7 153222 12084 42456022
Achromobacter infection 23.69 10.98 12 153217 168 42467938
Accidental exposure to product 23.66 10.98 23 153206 20370 42447736
Oral disorder 23.64 10.98 53 153176 4759 42463347
Musculoskeletal pain 23.63 10.98 53 153176 33287 42434819
Angina pectoris 23.55 10.98 52 153177 32844 42435262
Limb injury 23.47 10.98 11 153218 14294 42453812
Aspiration 23.39 10.98 18 153211 17868 42450238
Disseminated intravascular coagulation 23.34 10.98 161 153068 24633 42443473
Coma 23.29 10.98 106 153123 53448 42414658
Retinitis 23.21 10.98 17 153212 476 42467630
Papillary renal cell carcinoma 23.20 10.98 15 153214 341 42467765
Bone marrow transplant rejection 23.13 10.98 13 153216 227 42467879
Meningeal neoplasm 23.06 10.98 10 153219 96 42468010
Staphylococcal bacteraemia 23.02 10.98 90 153139 11031 42457075
Idiopathic intracranial hypertension 22.96 10.98 21 153208 809 42467297
BK polyomavirus test positive 22.96 10.98 9 153220 65 42468041
Metabolic acidosis 22.94 10.98 102 153127 51756 42416350
Hydronephrosis 22.94 10.98 94 153135 11771 42456335
Respiratory syncytial virus infection 22.89 10.98 67 153162 7085 42461021
Blood pressure systolic increased 22.78 10.98 41 153188 27927 42440179
Abdominal abscess 22.72 10.98 54 153175 5039 42463067
Granuloma 22.71 10.98 47 153182 3994 42464112
Haemorrhagic cyst 22.70 10.98 10 153219 100 42468006
Fungal test positive 22.64 10.98 18 153211 571 42467535
Hand deformity 22.57 10.98 45 153184 3723 42464383
Tracheitis 22.54 10.98 23 153206 1016 42467090
Cerebral fungal infection 22.49 10.98 15 153214 360 42467746
Squamous cell carcinoma of the tongue 22.45 10.98 15 153214 361 42467745
Brain oedema 22.41 10.98 117 153112 16210 42451896
Pneumonia klebsiella 22.39 10.98 48 153181 4181 42463925
Feeling hot 22.37 10.98 31 153198 23451 42444655
Undifferentiated sarcoma 22.32 10.98 7 153222 23 42468083
Acanthamoeba infection 22.31 10.98 17 153212 506 42467600
Urinary incontinence 22.30 10.98 27 153202 21641 42446465
Diabetes mellitus 22.19 10.98 321 152908 59766 42408340
Acanthosis 22.17 10.98 11 153218 147 42467959
Product quality issue 22.14 10.98 19 153210 17863 42450243
Palatal disorder 22.11 10.98 12 153217 195 42467911
Spinal instability 22.01 10.98 18 153211 595 42467511
Hyperfibrinogenaemia 21.95 10.98 10 153219 109 42467997
Debridement 21.94 10.98 22 153207 952 42467154
Hypothyroidism 21.93 10.98 52 153177 32032 42436074
Granuloma skin 21.92 10.98 24 153205 1151 42466955
Increased appetite 21.92 10.98 3 153226 8903 42459203
Glomerulonephritis proliferative 21.88 10.98 13 153216 253 42467853
Adenovirus reactivation 21.78 10.98 15 153214 380 42467726
Incorrect dose administered 21.78 10.98 107 153122 52867 42415239
Taste disorder 21.73 10.98 5 153224 10202 42457904
Blood pressure increased 21.67 10.98 248 152981 101680 42366426
Nasal congestion 21.65 10.98 46 153183 29455 42438651
Oesophageal squamous cell carcinoma 21.64 10.98 15 153214 384 42467722
Device related sepsis 21.60 10.98 45 153184 3842 42464264
Peripheral artery aneurysm 21.53 10.98 17 153212 534 42467572
Osteoarthritis 21.52 10.98 34 153195 24371 42443735
Knee arthroplasty 21.51 10.98 3 153226 8778 42459328
Immune effector cell-associated neurotoxicity syndrome 21.46 10.98 4 153225 9457 42458649
Plasmablastic lymphoma 21.45 10.98 18 153211 617 42467489
Neuralgia 21.43 10.98 37 153192 25610 42442496
Liver abscess 21.42 10.98 52 153177 4918 42463188
NPM1 gene mutation 21.40 10.98 10 153219 116 42467990
Anger 21.37 10.98 10 153219 13008 42455098
Autoinflammatory disease 21.35 10.98 9 153220 80 42468026
C-reactive protein increased 21.32 10.98 334 152895 63226 42404880
Upper respiratory tract inflammation 21.27 10.98 30 153199 1866 42466240
New onset diabetes after transplantation 21.27 10.98 12 153217 211 42467895
Lip ulceration 21.27 10.98 22 153207 988 42467118
Phototherapy 21.26 10.98 7 153222 28 42468078
Mesangioproliferative glomerulonephritis 21.22 10.98 11 153218 162 42467944
Depressed mood 21.17 10.98 32 153197 23352 42444754
Pollakiuria 21.15 10.98 30 153199 22475 42445631
Anogenital warts 21.13 10.98 19 153210 716 42467390
Blood test abnormal 21.06 10.98 10 153219 12896 42455210
Keratoacanthoma 21.05 10.98 21 153208 903 42467203
Oral lichenoid reaction 21.03 10.98 10 153219 121 42467985
Papule 21.02 10.98 57 153172 5769 42462337
Mantle cell lymphoma stage IV 20.99 10.98 8 153221 53 42468053
Cytogenetic abnormality 20.91 10.98 21 153208 910 42467196
Capillary leak syndrome 20.83 10.98 36 153193 2671 42465435
Cytomegalovirus gastrointestinal infection 20.81 10.98 14 153215 341 42467765
Lung abscess 20.80 10.98 40 153189 3223 42464883
Limb deformity 20.78 10.98 17 153212 562 42467544
Headache 20.77 10.98 679 152550 238690 42229416
B-cell lymphoma 20.75 10.98 51 153178 4862 42463244
Haematemesis 20.60 10.98 49 153180 30150 42437956
Adenomatous polyposis coli 20.58 10.98 11 153218 173 42467933
Mycobacterium abscessus infection 20.58 10.98 19 153210 741 42467365
Delusion of parasitosis 20.53 10.98 10 153219 128 42467978
Ageusia 20.51 10.98 8 153221 11597 42456509
Haemolytic anaemia 20.31 10.98 92 153137 12035 42456071
Bile duct stenosis 20.28 10.98 25 153204 1363 42466743
Loss of personal independence in daily activities 20.26 10.98 101 153128 49715 42418391
Glomerulonephritis minimal lesion 20.25 10.98 18 153211 668 42467438
Renal arteriosclerosis 20.21 10.98 13 153216 293 42467813
Respiratory tract inflammation 20.17 10.98 15 153214 430 42467676
Monoclonal B-cell lymphocytosis 20.15 10.98 8 153221 60 42468046
Perinephric collection 20.15 10.98 11 153218 181 42467925
Osteoporotic fracture 20.14 10.98 26 153203 1485 42466621
Marrow hyperplasia 20.14 10.98 24 153205 1263 42466843
Pulmonary thrombosis 20.11 10.98 3 153226 8345 42459761
Rib fracture 20.04 10.98 18 153211 16553 42451553
Hyperkeratosis 19.98 10.98 48 153181 4510 42463596
Intentional dose omission 19.95 10.98 4 153225 8982 42459124
Astrovirus test positive 19.85 10.98 7 153222 36 42468070
Renal cell carcinoma stage I 19.85 10.98 7 153222 36 42468070
Infective tenosynovitis 19.84 10.98 9 153220 97 42468009
Cyanosis 19.82 10.98 15 153214 15016 42453090
Periorbital infection 19.78 10.98 11 153218 188 42467918
Micturition urgency 19.75 10.98 9 153220 11889 42456217
Hip fracture 19.69 10.98 12 153217 13460 42454646
Oligospermia 19.68 10.98 9 153220 99 42468007
Meningitis viral 19.63 10.98 22 153207 1083 42467023
Miosis 19.62 10.98 12 153217 13434 42454672
Morphoea 19.61 10.98 12 153217 247 42467859
Malignant melanoma stage I 19.60 10.98 9 153220 100 42468006
Tooth hypoplasia 19.56 10.98 12 153217 248 42467858
Obstructive airways disorder 19.54 10.98 37 153192 24722 42443384
Scleral hyperaemia 19.50 10.98 8 153221 66 42468040
Fungaemia 19.45 10.98 38 153191 3098 42465008
Central nervous system vasculitis 19.44 10.98 17 153212 617 42467489
Blood immunoglobulin G decreased 19.43 10.98 32 153197 2282 42465824
Hepatic vein occlusion 19.40 10.98 12 153217 252 42467854
Musculoskeletal chest pain 19.35 10.98 8 153221 11196 42456910
Chronic inflammatory demyelinating polyradiculoneuropathy 19.21 10.98 23 153206 1216 42466890
Needle issue 19.14 10.98 4 153225 8723 42459383
Epstein-Barr virus antigen positive 19.09 10.98 7 153222 41 42468065
Rhinorrhoea 19.08 10.98 55 153174 31739 42436367
Dysarthria 19.03 10.98 76 153153 39731 42428375
Sporotrichosis 18.99 10.98 8 153221 71 42468035
Hypophagia 18.98 10.98 43 153186 26913 42441193
Nephrosclerosis 18.86 10.98 21 153208 1026 42467080
CSF cell count increased 18.81 10.98 7 153222 43 42468063
Bacterial abdominal infection 18.81 10.98 5 153224 7 42468099
Urinary tract infection enterococcal 18.70 10.98 21 153208 1036 42467070
Anaphylactic shock 18.69 10.98 35 153194 23482 42444624
Injection site mass 18.66 10.98 4 153225 8571 42459535
Type III immune complex mediated reaction 18.64 10.98 16 153213 566 42467540
Respiratory distress 18.58 10.98 231 152998 41589 42426517
Hydrocephalus 18.56 10.98 56 153173 6022 42462084
Product use issue 18.55 10.98 383 152846 76368 42391738
Endocarditis 18.55 10.98 68 153161 8084 42460022
Norovirus infection 18.53 10.98 18 153211 749 42467357
Citrobacter infection 18.52 10.98 17 153212 658 42467448
Middle insomnia 18.45 10.98 3 153226 7830 42460276
Influenza like illness 18.44 10.98 56 153173 31784 42436322
Arterial disorder 18.44 10.98 23 153206 1269 42466837
Blood parathyroid hormone decreased 18.44 10.98 26 153203 1617 42466489
Bone cyst 18.34 10.98 26 153203 1625 42466481
Epidermodysplasia verruciformis 18.29 10.98 12 153217 280 42467826
Malignant sweat gland neoplasm 18.22 10.98 6 153223 24 42468082
Papilloedema 18.21 10.98 38 153191 3248 42464858
Anti-cyclic citrullinated peptide antibody positive 18.20 10.98 28 153201 1884 42466222
Diarrhoea haemorrhagic 18.14 10.98 65 153164 7642 42460464
Ventricular extrasystoles 18.12 10.98 13 153216 13377 42454729
Hypomagnesaemia 18.05 10.98 48 153181 28440 42439666
Joint ankylosis 18.03 10.98 26 153203 1651 42466455
Bronchoalveolar lavage abnormal 17.89 10.98 9 153220 124 42467982
Sudden death 17.89 10.98 20 153209 16609 42451497
Enamel anomaly 17.82 10.98 11 153218 230 42467876
Mycobacterium marinum infection 17.73 10.98 15 153214 520 42467586
Wound dehiscence 17.72 10.98 41 153188 3759 42464347
Gingivitis ulcerative 17.70 10.98 11 153218 233 42467873
Cerebrosclerosis 17.66 10.98 6 153223 27 42468079
Refractoriness to platelet transfusion 17.65 10.98 8 153221 86 42468020
Pulmonary fibrosis 17.64 10.98 44 153185 26637 42441469
Uveitis 17.62 10.98 73 153156 9185 42458921
Skin neoplasm excision 17.61 10.98 14 153215 444 42467662
West Nile viral infection 17.58 10.98 19 153210 898 42467208
Transitional cell carcinoma 17.46 10.98 33 153196 2625 42465481
Haematoma evacuation 17.41 10.98 11 153218 240 42467866
Nail psoriasis 17.40 10.98 9 153220 132 42467974
Cancer surgery 17.30 10.98 15 153214 538 42467568
Cytopenia 17.30 10.98 115 153114 17382 42450724
Gynaecomastia 17.28 10.98 12 153217 12555 42455551
Paranoia 17.24 10.98 15 153214 14011 42454095
Dry eye 17.24 10.98 105 153124 15401 42452705
Visceral leishmaniasis 17.21 10.98 21 153208 1133 42466973
Cytomegalovirus enterocolitis 17.20 10.98 23 153206 1360 42466746
Fear 17.13 10.98 9 153220 10956 42457150
No adverse event 17.11 10.98 77 153152 38944 42429162
Seasonal allergy 17.04 10.98 4 153225 8051 42460055
Feeling cold 17.04 10.98 13 153216 12960 42455146
Hepatorenal syndrome 17.00 10.98 34 153195 2820 42465286
Trichosporon infection 16.99 10.98 19 153210 933 42467173
Herpes zoster 16.95 10.98 214 153015 38663 42429443
Post procedural urine leak 16.93 10.98 9 153220 140 42467966
Wound 16.91 10.98 22 153207 17095 42451011
Guillain-Barre syndrome 16.87 10.98 61 153168 7202 42460904
Ischaemic stroke 16.87 10.98 34 153195 22199 42445907
Cardiac valve abscess 16.83 10.98 6 153223 32 42468074
Stent removal 16.80 10.98 5 153224 13 42468093
Acute generalised exanthematous pustulosis 16.80 10.98 5 153224 8590 42459516
Ureteritis 16.76 10.98 9 153220 143 42467963
Anaplastic large cell lymphoma T- and null-cell types 16.76 10.98 9 153220 143 42467963
Withdrawal syndrome 16.75 10.98 17 153212 14758 42453348
Superficial injury of eye 16.74 10.98 8 153221 98 42468008
Disseminated cryptococcosis 16.68 10.98 27 153202 1898 42466208
Gastrointestinal mucosal disorder 16.66 10.98 14 153215 481 42467625
Streptococcal sepsis 16.65 10.98 27 153202 1901 42466205
Device malfunction 16.64 10.98 12 153217 12315 42455791
Oral mucosal exfoliation 16.64 10.98 10 153219 199 42467907
Pneumonia influenzal 16.64 10.98 27 153202 1902 42466204
Neurosyphilis 16.63 10.98 7 153222 62 42468044
Vascular device infection 16.54 10.98 54 153175 6056 42462050
Urethral polyp 16.53 10.98 7 153222 63 42468043
Hypopnoea 16.51 10.98 4 153225 7878 42460228
Rectal adenocarcinoma 16.45 10.98 19 153210 967 42467139
Pneumoretroperitoneum 16.38 10.98 9 153220 150 42467956
Throat tightness 16.35 10.98 7 153222 9592 42458514
Pyelonephritis 16.34 10.98 64 153165 7850 42460256
Sputum discoloured 16.30 10.98 8 153221 10124 42457982
Intra-aortic balloon placement 16.30 10.98 4 153225 3 42468103
Hodgkin's disease mixed cellularity stage unspecified 16.30 10.98 4 153225 3 42468103
Macrophage activation 16.30 10.98 4 153225 3 42468103
Urethral dilatation 16.30 10.98 4 153225 3 42468103
Familial haemophagocytic lymphohistiocytosis 16.30 10.98 4 153225 3 42468103
Tooth dislocation 16.28 10.98 5 153224 15 42468091
Myeloma cast nephropathy 16.18 10.98 8 153221 106 42468000
Enterococcal bacteraemia 16.16 10.98 32 153197 2635 42465471
Hippocampal sclerosis 16.12 10.98 9 153220 155 42467951
Ureteric obstruction 16.12 10.98 22 153207 1327 42466779
Cholestasis 16.09 10.98 185 153044 32694 42435412
Renal cell carcinoma 16.07 10.98 50 153179 5467 42462639
Therapeutic response shortened 16.06 10.98 15 153214 13539 42454567
Lichenification 15.97 10.98 14 153215 510 42467596
Disseminated varicella zoster vaccine virus infection 15.89 10.98 7 153222 70 42468036
Endocarditis bacterial 15.83 10.98 21 153208 1232 42466874
Plasma cell myeloma 15.82 10.98 103 153126 47475 42420631
Illness 15.80 10.98 42 153187 24888 42443218
Transfusion associated graft versus host disease 15.77 10.98 4 153225 4 42468102
Demyelinating polyneuropathy 15.77 10.98 24 153205 1600 42466506
Infertility 15.68 10.98 10 153219 222 42467884
Disseminated Bacillus Calmette-Guerin infection 15.66 10.98 11 153218 288 42467818
Lichenoid keratosis 15.63 10.98 40 153189 3910 42464196
Serratia infection 15.62 10.98 21 153208 1248 42466858
Jejunal ulcer 15.61 10.98 8 153221 115 42467991
Urinary bladder haematoma 15.59 10.98 5 153224 18 42468088
Botryomycosis 15.59 10.98 6 153223 41 42468065
Bronchospasm 15.57 10.98 14 153215 12871 42455235
Melaena 15.50 10.98 79 153150 38667 42429439
Diverticulitis 15.49 10.98 37 153192 22736 42445370
Renal tubular injury 15.48 10.98 25 153204 1754 42466352
Hyperbilirubinaemia 15.47 10.98 127 153102 20508 42447598
Retinal scar 15.41 10.98 12 153217 369 42467737
Neoplasm progression 15.41 10.98 53 153176 28947 42439159
Ophthalmic herpes simplex 15.39 10.98 12 153217 370 42467736
Meningococcal sepsis 15.39 10.98 7 153222 76 42468030
Hair follicle tumour benign 15.38 10.98 5 153224 19 42468087
Corneal leukoma 15.38 10.98 5 153224 19 42468087
Arteriovenous fistula aneurysm 15.38 10.98 5 153224 19 42468087
Infection in an immunocompromised host 15.38 10.98 19 153210 1038 42467068
Cutaneous mucormycosis 15.32 10.98 15 153214 630 42467476
Superficial spreading melanoma stage unspecified 15.25 10.98 10 153219 233 42467873
Vitamin D deficiency 15.23 10.98 5 153224 8068 42460038
Nerve conduction studies abnormal 15.23 10.98 6 153223 44 42468062
Umbilical hernia repair 15.23 10.98 6 153223 44 42468062
Lung lobectomy 15.23 10.98 7 153222 78 42468028
Quadriparesis 15.22 10.98 29 153200 2321 42465785
Tongue ulceration 15.18 10.98 22 153207 1403 42466703
Colitis herpes 15.18 10.98 5 153224 20 42468086
Neck pain 15.18 10.98 56 153173 29958 42438148
Microangiopathy 15.13 10.98 24 153205 1658 42466448
Gastrointestinal infection 15.13 10.98 56 153173 6687 42461419
Sertoli-cell-only syndrome 15.11 10.98 6 153223 45 42468061
Intestinal ulcer 15.10 10.98 19 153210 1058 42467048
Lung neoplasm 15.08 10.98 44 153185 4644 42463462
Urinary tract infection viral 15.00 10.98 6 153223 46 42468060
Chronic kidney disease 15.00 10.98 246 152983 46995 42421111
Ejection fraction decreased 14.93 10.98 36 153193 22051 42446055
Non-Hodgkin's lymphoma 14.93 10.98 22 153207 1425 42466681
Cutaneous tuberculosis 14.90 10.98 8 153221 127 42467979
Abdominal hernia repair 14.89 10.98 6 153223 47 42468059
Ureteric anastomosis complication 14.89 10.98 6 153223 47 42468059
Ecthyma 14.88 10.98 15 153214 653 42467453
Atrioventricular block 14.86 10.98 8 153221 9607 42458499
Nervousness 14.86 10.98 16 153213 13516 42454590
Eyelid irritation 14.85 10.98 12 153217 390 42467716
Gouty tophus 14.85 10.98 9 153220 182 42467924
Hospice care 14.83 10.98 6 153223 8507 42459599
Neoplasm skin 14.82 10.98 19 153210 1078 42467028
Hallucination, auditory 14.79 10.98 19 153210 14845 42453261
Renal tubular disorder 14.77 10.98 45 153184 4864 42463242
Product administered to patient of inappropriate age 14.66 10.98 44 153185 4717 42463389
Blood calcium increased 14.66 10.98 6 153223 8448 42459658
Myelitis transverse 14.65 10.98 21 153208 1326 42466780
Iron deficiency 14.63 10.98 11 153218 11050 42457056
Viral myositis 14.63 10.98 5 153224 23 42468083
Growth disorder 14.63 10.98 7 153222 86 42468020
Acute myeloid leukaemia 14.61 10.98 133 153096 22123 42445983
Arrhythmia 14.59 10.98 85 153144 40232 42427874
Poor venous access 14.58 10.98 4 153225 7248 42460858
Palatal ulcer 14.57 10.98 6 153223 50 42468056
Influenza 14.52 10.98 148 153081 62027 42406079
Heparin-induced thrombocytopenia 14.52 10.98 3 153226 6594 42461512
Skin cancer metastatic 14.51 10.98 4 153225 7 42468099
Herpes simplex oesophagitis 14.50 10.98 10 153219 254 42467852
Sebaceous carcinoma 14.48 10.98 7 153222 88 42468018
Type 3 diabetes mellitus 14.48 10.98 7 153222 88 42468018
Hallucination, visual 14.42 10.98 34 153195 20986 42447120
Urinoma 14.36 10.98 10 153219 258 42467848
Blood glucose decreased 14.34 10.98 18 153211 14201 42453905
Tuberculoma of central nervous system 14.33 10.98 10 153219 259 42467847
Nasopharyngeal cancer 14.32 10.98 8 153221 138 42467968
Urinary bladder toxicity 14.29 10.98 5 153224 25 42468081
CSF pressure increased 14.29 10.98 5 153224 25 42468081
Explorative laparotomy 14.29 10.98 5 153224 25 42468081
Dermatitis acneiform 14.24 10.98 5 153224 7734 42460372
Product container issue 14.23 10.98 17 153212 897 42467209
Coombs direct test positive 14.22 10.98 11 153218 335 42467771
Atrioventricular block first degree 14.18 10.98 3 153226 6488 42461618
Mental status changes 14.09 10.98 91 153138 42024 42426082
Limbic encephalitis 14.09 10.98 12 153217 420 42467686
Bifidobacterium infection 14.08 10.98 7 153222 94 42468012
Drug level decreased 14.04 10.98 72 153157 9905 42458201
Anti-platelet antibody positive 14.00 10.98 10 153219 269 42467837
Myasthenic syndrome 14.00 10.98 16 153213 805 42467301
Superinfection bacterial 13.99 10.98 21 153208 1383 42466723
Subacute sclerosing panencephalitis 13.98 10.98 5 153224 27 42468079
Chest expansion decreased 13.97 10.98 8 153221 145 42467961
Underdose 13.96 10.98 24 153205 16642 42451464
H1N1 influenza 13.93 10.98 19 153210 1145 42466961
Vascular graft complication 13.92 10.98 8 153221 146 42467960
Renal cell carcinoma stage II 13.90 10.98 3 153226 0 42468106
Good syndrome 13.90 10.98 3 153226 0 42468106
Transplant abscess 13.90 10.98 3 153226 0 42468106
Gingivectomy 13.90 10.98 3 153226 0 42468106
Endocarditis pseudomonal 13.90 10.98 3 153226 0 42468106
Ureteric repair 13.90 10.98 3 153226 0 42468106
Cyst drainage 13.90 10.98 3 153226 0 42468106
Nail candida 13.90 10.98 3 153226 0 42468106
Bence Jones protein urine present 13.90 10.98 3 153226 0 42468106
Hepatitis B e antigen 13.90 10.98 3 153226 0 42468106
Hair growth rate abnormal 13.90 10.98 3 153226 0 42468106
Cytomegalovirus urinary tract infection 13.90 10.98 3 153226 0 42468106
Acquired amegakaryocytic thrombocytopenia 13.90 10.98 3 153226 0 42468106
Primary mediastinal large B-cell lymphoma 13.90 10.98 3 153226 0 42468106
Hepatitis viral 13.87 10.98 16 153213 813 42467293
Graft complication 13.84 10.98 15 153214 711 42467395
Ejection fraction abnormal 13.81 10.98 20 153209 1275 42466831
Thoracotomy 13.76 10.98 7 153222 99 42468007
Gammopathy 13.76 10.98 7 153222 99 42468007
Mood altered 13.75 10.98 11 153218 10707 42457399
Rash pruritic 13.74 10.98 68 153161 33535 42434571
Red blood cell abnormality 13.71 10.98 12 153217 436 42467670
Gastroenteritis Escherichia coli 13.69 10.98 17 153212 934 42467172
Dengue fever 13.66 10.98 12 153217 438 42467668
Speech disorder 13.66 10.98 56 153173 29065 42439041
Abscess drainage 13.65 10.98 11 153218 356 42467750
Pneumonia viral 13.64 10.98 40 153189 4234 42463872
Spindle cell sarcoma 13.64 10.98 8 153221 152 42467954
Blood sodium decreased 13.59 10.98 28 153201 18134 42449972
Atelectasis 13.54 10.98 31 153198 19330 42448776
Ventricular arrhythmia 13.52 10.98 3 153226 6276 42461830
Blood cholesterol increased 13.46 10.98 50 153179 26691 42441415
Glycosylated haemoglobin increased 13.41 10.98 16 153213 12908 42455198
Fibrosis 13.38 10.98 32 153197 2998 42465108
Haemoptysis 13.37 10.98 104 153125 46063 42422043
Toxic encephalopathy 13.37 10.98 55 153174 6898 42461208
Cytomegalovirus gastrointestinal ulcer 13.33 10.98 7 153222 106 42468000
Oral mucosal erythema 13.33 10.98 14 153215 640 42467466
Pityriasis rubra pilaris 13.29 10.98 10 153219 292 42467814
Supraventricular tachycardia 13.26 10.98 15 153214 12393 42455713
Splenic abscess 13.26 10.98 14 153215 644 42467462
Coronary artery occlusion 13.23 10.98 12 153217 10985 42457121
Fungal abscess central nervous system 13.23 10.98 8 153221 161 42467945
Anal squamous cell carcinoma 13.23 10.98 8 153221 161 42467945
Psychotic disorder 13.19 10.98 57 153172 29151 42438955
Parakeratosis 13.17 10.98 9 153220 225 42467881
Intervertebral disc degeneration 13.15 10.98 5 153224 7362 42460744
Meningoencephalitis amoebic 13.14 10.98 9 153220 226 42467880
Atrial septal defect 13.13 10.98 6 153223 7913 42460193
Peritonitis 13.08 10.98 113 153116 18520 42449586
Pulseless electrical activity 13.07 10.98 7 153222 8430 42459676
Subcapsular renal haematoma 13.07 10.98 13 153216 557 42467549
Corynebacterium infection 13.05 10.98 16 153213 867 42467239
Disorientation 13.02 10.98 77 153152 36312 42431794
Gingival oedema 13.01 10.98 5 153224 34 42468072
Colitis 12.99 10.98 106 153123 46466 42421640
Apathy 12.98 10.98 7 153222 8399 42459707
Inguinal hernia 12.94 10.98 8 153221 8904 42459202
Mucosal erosion 12.94 10.98 17 153212 988 42467118
Product dose omission in error 12.84 10.98 7 153222 8347 42459759
Metastases to central nervous system 12.82 10.98 11 153218 10344 42457762
Renal cell carcinoma stage III 12.79 10.98 4 153225 13 42468093
Dizziness postural 12.78 10.98 6 153223 7789 42460317
Abdominal wall abscess 12.78 10.98 14 153215 672 42467434
Cutaneous T-cell lymphoma stage I 12.78 10.98 7 153222 116 42467990
Reticulocytopenia 12.77 10.98 8 153221 172 42467934
Full blood count decreased 12.76 10.98 35 153194 20525 42447581
Renal vein thrombosis 12.74 10.98 12 153217 480 42467626
Activated partial thromboplastin time shortened 12.74 10.98 12 153217 480 42467626
Blood urine present 12.74 10.98 14 153215 11719 42456387
Bordetella infection 12.72 10.98 8 153221 173 42467933
Intracranial tumour haemorrhage 12.72 10.98 11 153218 393 42467713
Rhinocerebral mucormycosis 12.71 10.98 14 153215 676 42467430
Hiccups 12.70 10.98 15 153214 12156 42455950
Prostate cancer metastatic 12.69 10.98 4 153225 6625 42461481
Pseudomembranous colitis 12.68 10.98 32 153197 3101 42465005
Mucocutaneous leishmaniasis 12.67 10.98 7 153222 118 42467988
Lesion excision 12.65 10.98 5 153224 37 42468069
Prescribed underdose 12.63 10.98 11 153218 10271 42457835
Endotracheal intubation 12.63 10.98 36 153193 3749 42464357
Gingival swelling 12.63 10.98 20 153209 1380 42466726
Aspartate aminotransferase increased 12.59 10.98 365 152864 76798 42391308
Atrial flutter 12.57 10.98 27 153202 17224 42450882
Lung squamous cell carcinoma stage IV 12.54 10.98 5 153224 38 42468068
Aspergillus test positive 12.53 10.98 14 153215 687 42467419
Bronchopneumopathy 12.53 10.98 13 153216 586 42467520
Hyperaesthesia 12.51 10.98 3 153226 5949 42462157
Weight fluctuation 12.50 10.98 3 153226 5948 42462158
Drug intolerance 12.47 10.98 378 152851 80046 42388060
Reticulocyte count decreased 12.46 10.98 14 153215 691 42467415
Herpes ophthalmic 12.43 10.98 14 153215 693 42467413
Mediastinitis 12.42 10.98 17 153212 1028 42467078
Joint injury 12.42 10.98 21 153208 14655 42453451
Peripheral T-cell lymphoma unspecified 12.40 10.98 13 153216 593 42467513
Biliary catheter insertion 12.37 10.98 6 153223 76 42468030
Acid fast bacilli infection 12.36 10.98 7 153222 124 42467982
Severe acute respiratory syndrome 12.36 10.98 7 153222 124 42467982
Tricuspid valve incompetence 12.36 10.98 13 153216 11100 42457006
Oral papilloma 12.35 10.98 4 153225 15 42468091
Metastases to nasal sinuses 12.35 10.98 4 153225 15 42468091
Injection site hypersensitivity 12.26 10.98 11 153218 413 42467693
Osteitis 12.25 10.98 22 153207 1682 42466424
Hyporeflexia 12.24 10.98 26 153203 2250 42465856
Viral uveitis 12.21 10.98 5 153224 41 42468065
Sebaceous adenoma 12.21 10.98 5 153224 41 42468065
Eccrine squamous syringometaplasia 12.21 10.98 5 153224 41 42468065
Nephrogenic diabetes insipidus 12.20 10.98 21 153208 1553 42466553
Skin erosion 12.20 10.98 30 153199 2861 42465245
Clonal evolution 12.17 10.98 7 153222 128 42467978
Iris neoplasm 12.15 10.98 4 153225 16 42468090
Gastroenteritis cryptosporidial 12.10 10.98 9 153220 258 42467848
Visual acuity reduced 12.09 10.98 106 153123 17444 42450662
Faeces discoloured 12.09 10.98 27 153202 16987 42451119
Torsade de pointes 12.09 10.98 8 153221 8586 42459520
Gastroenteritis norovirus 12.08 10.98 22 153207 1701 42466405
Angina unstable 12.06 10.98 14 153215 11434 42456672
Cardiac hypertrophy 12.02 10.98 18 153211 1183 42466923
Cutaneous leishmaniasis 12.01 10.98 9 153220 261 42467845
T-cell lymphoma recurrent 12.01 10.98 5 153224 43 42468063
Skin neoplasm bleeding 11.96 10.98 4 153225 17 42468089
Echo virus infection 11.96 10.98 4 153225 17 42468089
Myocarditis 11.93 10.98 32 153197 18906 42449200
Campylobacter gastroenteritis 11.93 10.98 17 153212 1068 42467038
Nephrostomy 11.93 10.98 9 153220 264 42467842
Blood pressure abnormal 11.92 10.98 11 153218 9987 42458119
Azoospermia 11.91 10.98 12 153217 522 42467584
Gastrointestinal haemorrhage 11.91 10.98 264 152965 97462 42370644
Sneezing 11.90 10.98 4 153225 6359 42461747
Osteolysis 11.90 10.98 34 153195 3546 42464560
Semen volume decreased 11.89 10.98 10 153219 344 42467762
Hepatitis B surface antigen positive 11.88 10.98 7 153222 134 42467972
Disseminated toxoplasmosis 11.87 10.98 9 153220 266 42467840
Psoriasis area severity index increased 11.84 10.98 6 153223 84 42468022
Penile squamous cell carcinoma 11.84 10.98 6 153223 84 42468022
Secondary immunodeficiency 11.84 10.98 15 153214 841 42467265
Renal arteritis 11.83 10.98 3 153226 3 42468103
Hepatobiliary cancer 11.83 10.98 3 153226 3 42468103
Ureteral stent removal 11.83 10.98 3 153226 3 42468103
Vascular graft infection 11.83 10.98 3 153226 3 42468103
Peripheral artery dissection 11.83 10.98 3 153226 3 42468103
Ureteric operation 11.83 10.98 3 153226 3 42468103
Skin hypertrophy 11.83 10.98 29 153200 2760 42465346
Cold sweat 11.78 10.98 14 153215 11316 42456790
Cholangitis chronic 11.77 10.98 4 153225 18 42468088
Clostridium difficile infection 11.77 10.98 129 153100 22530 42445576
Blood iron decreased 11.77 10.98 4 153225 6314 42461792
Aeromonas infection 11.74 10.98 10 153219 350 42467756
Biopsy liver 11.72 10.98 9 153220 271 42467835
Poor quality sleep 11.72 10.98 10 153219 9430 42458676
Cytomegalovirus test 11.71 10.98 5 153224 46 42468060
Necrotising herpetic retinopathy 11.71 10.98 5 153224 46 42468060
Device occlusion 11.71 10.98 8 153221 8442 42459664
Blood pressure diastolic decreased 11.69 10.98 12 153217 10363 42457743
Splenic candidiasis 11.66 10.98 6 153223 87 42468019
Immune-mediated enterocolitis 11.66 10.98 3 153226 5674 42462432
Throat irritation 11.64 10.98 18 153211 13018 42455088
Corneal graft rejection 11.62 10.98 5 153224 47 42468059
Tuberculosis 11.62 10.98 69 153160 10030 42458076
Lymphangitis 11.61 10.98 13 153216 639 42467467
Sciatica 11.61 10.98 6 153223 7371 42460735
Retroperitoneal neoplasm 11.60 10.98 4 153225 19 42468087
Cerebral aspergillosis 11.59 10.98 22 153207 1755 42466351
Hyperphosphataemia 11.57 10.98 18 153211 12986 42455120
Nocturia 11.53 10.98 16 153213 12096 42456010
Papillary cystadenoma lymphomatosum 11.53 10.98 5 153224 48 42468058
Eye discharge 11.51 10.98 30 153199 2965 42465141
Retching 11.39 10.98 7 153222 7814 42460292
Chronic active Epstein-Barr virus infection 11.37 10.98 3 153226 4 42468102
Dermatitis atopic 11.35 10.98 80 153149 12324 42455782
Herpes zoster cutaneous disseminated 11.34 10.98 8 153221 211 42467895
Gastrointestinal stromal tumour 11.31 10.98 17 153212 1121 42466985
Orchitis 11.29 10.98 25 153204 2226 42465880
Oropharyngeal pain 11.29 10.98 98 153131 42412 42425694
Blood calcium decreased 11.26 10.98 14 153215 11094 42457012
Chills 11.21 10.98 255 152974 93811 42374295
Injection site bruising 11.20 10.98 15 153214 11510 42456596
Ophthalmic vein thrombosis 11.18 10.98 5 153224 52 42468054
Microsporidia infection 11.15 10.98 17 153212 1135 42466971
Hypospermia 11.12 10.98 4 153225 22 42468084
Complement factor C3 decreased 11.09 10.98 5 153224 53 42468053
Ureteral necrosis 11.09 10.98 5 153224 53 42468053
Thymoma 11.07 10.98 7 153222 153 42467953
Tooth extraction 11.06 10.98 3 153226 5477 42462629
Concomitant disease aggravated 11.06 10.98 50 153179 6536 42461570
Cystitis 11.03 10.98 76 153153 11622 42456484
Dementia 11.03 10.98 27 153202 16453 42451653
Low turnover osteopathy 11.03 10.98 6 153223 98 42468008
Computerised tomogram abnormal 11.01 10.98 23 153206 1967 42466139
Oral herpes 11.01 10.98 55 153174 7489 42460617
Mania 11.00 10.98 13 153216 10534 42457572

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 3778.42 9.75 2158 298641 52286 110236214
Graft versus host disease 2693.51 9.75 1217 299582 17589 110270911
Acute graft versus host disease 2567.15 9.75 1053 299746 11828 110276672
Acute graft versus host disease in skin 2229.23 9.75 904 299895 9836 110278664
Chronic graft versus host disease 2164.05 9.75 854 299945 8603 110279897
Epstein-Barr virus infection 1881.34 9.75 950 299849 17788 110270712
Post transplant lymphoproliferative disorder 1852.36 9.75 887 299912 14726 110273774
Product use in unapproved indication 1824.54 9.75 3860 296939 443517 109844983
Transplant rejection 1779.42 9.75 1002 299797 23565 110264935
BK virus infection 1740.94 9.75 805 299994 12301 110276199
Cytomegalovirus infection reactivation 1634.20 9.75 858 299941 17475 110271025
Transplant dysfunction 1605.74 9.75 665 300134 7663 110280837
Graft versus host disease in gastrointestinal tract 1604.69 9.75 679 300120 8289 110280211
Posterior reversible encephalopathy syndrome 1369.58 9.75 954 299845 32907 110255593
Graft versus host disease in skin 1319.21 9.75 577 300222 7677 110280823
Thrombotic microangiopathy 1178.27 9.75 821 299978 28328 110260172
Cystitis haemorrhagic 1176.02 9.75 602 300197 11607 110276893
Acute graft versus host disease in intestine 1140.53 9.75 466 300333 5173 110283327
Kidney transplant rejection 1116.93 9.75 578 300221 11409 110277091
Drug ineffective 1090.74 9.75 7453 293346 1513087 108775413
Nephropathy toxic 950.31 9.75 704 300095 26774 110261726
Adenovirus infection 874.31 9.75 477 300322 10517 110277983
Eye irritation 854.78 9.75 717 300082 32735 110255765
Cytomegalovirus viraemia 838.84 9.75 551 300248 17213 110271287
Renal impairment 829.20 9.75 1680 299119 186765 110101735
Epstein-Barr virus associated lymphoproliferative disorder 707.21 9.75 317 300482 4485 110284015
Ovarian cyst 691.85 9.75 446 300353 13484 110275016
Multiple organ dysfunction syndrome 684.53 9.75 1367 299432 150343 110138157
Aspergillus infection 673.00 9.75 558 300241 25058 110263442
Off label use 648.80 9.75 6567 294232 1493618 108794882
Bronchopulmonary aspergillosis 641.80 9.75 580 300219 29283 110259217
Completed suicide 612.33 9.75 9 300790 242372 110046128
Acute graft versus host disease in liver 603.30 9.75 231 300568 2128 110286372
Drug ineffective for unapproved indication 599.84 9.75 1035 299764 101803 110186697
Haemophagocytic lymphohistiocytosis 582.11 9.75 563 300236 30996 110257504
Blood creatinine increased 559.94 9.75 1412 299387 181477 110107023
Chronic graft versus host disease in skin 559.06 9.75 225 300574 2394 110286106
Gingival hypertrophy 540.96 9.75 255 300544 4076 110284424
Dizziness 528.34 9.75 675 300124 697518 109590982
Fall 503.12 9.75 540 300259 602942 109685558
Epstein-Barr virus infection reactivation 502.56 9.75 238 300561 3846 110284654
Fatigue 487.72 9.75 1689 299110 1214269 109074231
Immunosuppressant drug level increased 461.54 9.75 325 300474 11399 110277101
Polyomavirus-associated nephropathy 440.70 9.75 276 300523 7925 110280575
Disease recurrence 438.92 9.75 674 300125 60110 110228390
Acne 417.05 9.75 485 300314 33035 110255465
Complications of transplanted kidney 413.91 9.75 256 300543 7186 110281314
Pneumonia cytomegaloviral 406.66 9.75 247 300552 6707 110281793
Dyspnoea 405.74 9.75 1595 299204 1105277 109183223
Mucosal inflammation 401.14 9.75 839 299960 95302 110193198
Human herpesvirus 6 infection 400.98 9.75 240 300559 6341 110282159
Venoocclusive liver disease 398.90 9.75 331 300468 14876 110273624
Drug abuse 396.08 9.75 21 300778 177390 110111110
Graft versus host disease in liver 389.59 9.75 171 300628 2294 110286206
Liver transplant rejection 385.45 9.75 196 300603 3722 110284778
Wheezing 374.83 9.75 114 300685 255116 110033384
Drug eruption 369.29 9.75 582 300217 53077 110235423
Epstein-Barr viraemia 366.60 9.75 184 300615 3395 110285105
Blood parathyroid hormone decreased 360.29 9.75 293 300506 12796 110275704
Panniculitis 359.35 9.75 315 300484 15267 110273233
Pemphigus 357.23 9.75 74 300725 214496 110074004
Viral haemorrhagic cystitis 354.81 9.75 177 300622 3222 110285278
Glossodynia 354.60 9.75 84 300715 221920 110066580
Basal cell carcinoma 353.93 9.75 521 300278 44749 110243751
Polyomavirus viraemia 351.15 9.75 177 300622 3297 110285203
Pseudomonas infection 346.50 9.75 403 300396 27450 110261050
Viraemia 340.13 9.75 183 300616 3919 110284581
Hypotension 339.39 9.75 564 300235 523285 109765215
Transplant failure 334.27 9.75 202 300597 5433 110283067
Skin necrosis 331.13 9.75 348 300451 21164 110267336
Asthenia 328.96 9.75 882 299917 688117 109600383
Granuloma skin 326.34 9.75 260 300539 11023 110277477
Confusional state 323.10 9.75 484 300315 468196 109820304
Pneumocystis jirovecii pneumonia 320.01 9.75 482 300317 42253 110246247
Muscle injury 319.62 9.75 15 300784 140792 110147708
Intentional overdose 318.39 9.75 9 300790 132492 110156008
Drug resistance 317.69 9.75 559 300240 55815 110232685
Chronic graft versus host disease in liver 316.03 9.75 112 300687 810 110287690
Irritable bowel syndrome 310.42 9.75 40 300759 164175 110124325
Cytomegalovirus test positive 309.85 9.75 209 300590 6827 110281673
Hand deformity 309.45 9.75 104 300695 218402 110070098
Heart transplant rejection 296.28 9.75 133 300666 1888 110286612
Swelling 293.41 9.75 313 300486 350728 109937772
Folliculitis 291.38 9.75 52 300747 167601 110120899
Hepatic function abnormal 288.44 9.75 704 300095 88591 110199909
Systemic lupus erythematosus 287.89 9.75 167 300632 254171 110034329
Duodenal ulcer perforation 284.23 9.75 67 300732 177633 110110867
Pericarditis 284.03 9.75 120 300679 218994 110069506
Obliterative bronchiolitis 283.52 9.75 157 300642 3566 110284934
Venoocclusive disease 282.93 9.75 190 300609 6160 110282340
Wound 282.79 9.75 142 300657 234295 110054205
Nausea 281.78 9.75 2088 298711 1233602 109054898
Anxiety 274.90 9.75 320 300479 344758 109943742
Mucormycosis 271.85 9.75 228 300571 10400 110278100
Treatment failure 269.56 9.75 1475 299324 275759 110012741
Herpes simplex 267.94 9.75 269 300530 15495 110273005
Lower respiratory tract infection 264.83 9.75 167 300632 242939 110045561
Cytomegalovirus colitis 262.41 9.75 189 300610 6872 110281628
Encephalitis cytomegalovirus 261.99 9.75 120 300679 1790 110286710
Vomiting 260.48 9.75 1435 299364 909240 109379260
Bursitis 259.71 9.75 26 300773 129892 110158608
Helicobacter infection 258.51 9.75 86 300713 181791 110106709
Somnolence 257.84 9.75 257 300542 297192 109991308
Constipation 256.79 9.75 359 300440 357427 109931073
Pain 254.82 9.75 1539 299260 953416 109335084
Lymphoproliferative disorder 254.16 9.75 187 300612 7031 110281469
Chronic allograft nephropathy 252.76 9.75 121 300678 2005 110286495
Malaise 250.65 9.75 960 299839 670859 109617641
Squamous cell carcinoma 249.74 9.75 279 300520 18184 110270316
Hypoaesthesia 249.60 9.75 292 300507 313931 109974569
Asthma 248.70 9.75 190 300609 250101 110038399
Rheumatic fever 246.42 9.75 24 300775 122555 110165945
Rheumatoid nodule 244.70 9.75 289 300510 20007 110268493
Proteinuria 242.74 9.75 410 300389 39608 110248892
Smooth muscle cell neoplasm 242.58 9.75 104 300695 1313 110287187
Weight increased 242.04 9.75 485 300314 419159 109869341
Injury 241.35 9.75 90 300709 177175 110111325
JC virus infection 239.82 9.75 160 300639 5130 110283370
Abdominal pain upper 239.05 9.75 362 300437 348749 109939751
Hypogammaglobulinaemia 238.96 9.75 284 300515 19792 110268708
Abdominal discomfort 238.64 9.75 442 300357 393416 109895084
Eye pain 237.30 9.75 461 300338 49638 110238862
Decreased appetite 236.92 9.75 596 300203 475250 109813250
Gastrooesophageal reflux disease 230.95 9.75 100 300699 179876 110108624
Syncope 227.75 9.75 134 300665 202402 110086098
Nasopharyngitis 226.37 9.75 457 300342 393904 109894596
Therapy non-responder 225.78 9.75 937 299862 156370 110132130
Cystitis viral 225.75 9.75 100 300699 1373 110287127
Fibromyalgia 225.69 9.75 91 300708 170818 110117682
Facet joint syndrome 224.09 9.75 9 300790 96819 110191681
Bacterial infection 222.19 9.75 427 300372 45609 110242891
Immunosuppressant drug level decreased 219.68 9.75 120 300679 2651 110285849
Depression 219.23 9.75 327 300472 317008 109971492
Anti-cyclic citrullinated peptide antibody positive 213.84 9.75 114 300685 181870 110106630
Foreign body sensation in eyes 212.03 9.75 125 300674 3209 110285291
Septic shock 211.13 9.75 919 299880 156609 110131891
Sepsis 209.36 9.75 1566 299233 325780 109962720
Lip dry 208.18 9.75 17 300782 100066 110188434
Death 208.04 9.75 1086 299713 697783 109590717
Sleep disorder 206.15 9.75 144 300655 198500 110090000
Complications of bone marrow transplant 203.23 9.75 74 300725 584 110287916
Lung transplant rejection 202.87 9.75 101 300698 1830 110286670
Discomfort 198.38 9.75 175 300624 214532 110073968
Staphylococcal infection 197.34 9.75 524 300275 69420 110219080
Renal transplant failure 195.85 9.75 110 300689 2570 110285930
Renal failure 195.55 9.75 1168 299631 225406 110063094
Pancytopenia 195.49 9.75 1103 299696 208510 110079990
Type 2 diabetes mellitus 195.41 9.75 120 300679 177112 110111388
Diffuse large B-cell lymphoma 194.36 9.75 228 300571 15670 110272830
Enthesopathy 192.29 9.75 202 300597 12276 110276224
Enterococcal infection 191.32 9.75 256 300543 20110 110268390
General physical health deterioration 190.39 9.75 561 300238 424734 109863766
Nocardiosis 190.24 9.75 160 300639 7326 110281174
Chronic graft versus host disease in intestine 188.84 9.75 71 300728 619 110287881
Memory impairment 188.70 9.75 155 300644 196789 110091711
Cutaneous T-cell lymphoma 187.16 9.75 116 300683 3268 110285232
Cytomegalovirus chorioretinitis 186.63 9.75 155 300644 6973 110281527
Contusion 186.19 9.75 216 300583 233145 110055355
Skin ulcer 185.87 9.75 483 300316 63162 110225338
Therapeutic response decreased 184.31 9.75 630 300169 95869 110192631
Swollen joint count increased 183.31 9.75 11 300788 83650 110204850
Impaired healing 180.94 9.75 161 300638 196556 110091944
Chest pain 179.90 9.75 481 300318 375894 109912606
Paraesthesia 179.51 9.75 297 300502 276224 110012276
Product dose omission issue 178.60 9.75 380 300419 321402 109967098
Breast cancer stage III 177.70 9.75 9 300790 79108 110209392
Fungal infection 177.47 9.75 413 300386 50393 110238107
Dehydration 177.03 9.75 305 300494 279206 110009294
Aplastic anaemia 176.08 9.75 270 300529 24038 110264462
Kidney fibrosis 175.78 9.75 123 300676 4269 110284231
Ulcer 174.81 9.75 372 300427 42744 110245756
Bacteraemia 173.33 9.75 367 300432 42023 110246477
Focal segmental glomerulosclerosis 172.73 9.75 119 300680 4026 110284474
Road traffic accident 168.76 9.75 42 300757 107356 110181144
Prescribed overdose 168.75 9.75 20 300779 87561 110200939
Dry mouth 168.39 9.75 177 300622 199771 110088729
Bradycardia 167.72 9.75 108 300691 155409 110133091
Acute myeloid leukaemia recurrent 167.25 9.75 127 300672 5012 110283488
Skin lesion 166.63 9.75 407 300392 51224 110237276
Neurotoxicity 166.35 9.75 360 300439 41847 110246653
Alveolar proteinosis 166.30 9.75 82 300717 1454 110287046
Hyperhidrosis 165.51 9.75 159 300640 187139 110101361
Oral administration complication 163.84 9.75 44 300755 101 110288399
Hypercalcaemia 163.77 9.75 380 300419 46277 110242223
Varicella zoster virus infection 163.67 9.75 137 300662 6231 110282269
Hypokalaemia 163.42 9.75 153 300646 182295 110106205
Alanine aminotransferase abnormal 161.81 9.75 161 300638 9173 110279327
Tenosynovitis 159.62 9.75 209 300590 16074 110272426
Suicide attempt 159.46 9.75 42 300757 103352 110185148
Instillation site pain 158.92 9.75 64 300735 682 110287818
Ocular hyperaemia 157.02 9.75 337 300462 38949 110249551
Haemolysis 156.83 9.75 203 300596 15436 110273064
Blood bilirubin increased 156.64 9.75 509 300290 75463 110213037
Graft versus host disease in lung 155.79 9.75 74 300725 1204 110287296
Electrocardiogram QT prolonged 155.72 9.75 51 300748 108909 110179591
Kaposi's sarcoma 155.70 9.75 62 300737 640 110287860
Respiratory failure 155.48 9.75 1061 299738 214271 110074229
Blister 155.34 9.75 236 300563 227140 110061360
Aplasia pure red cell 154.68 9.75 159 300640 9419 110279081
Hyponatraemia 154.46 9.75 220 300579 217433 110071067
SLE arthritis 154.42 9.75 60 300739 577 110287923
Night sweats 152.94 9.75 87 300712 133896 110154604
Palpitations 152.89 9.75 125 300674 159087 110129413
Klebsiella infection 151.66 9.75 227 300572 19782 110268718
Ill-defined disorder 150.81 9.75 123 300676 156730 110131770
Encephalitis viral 148.62 9.75 96 300703 2911 110285589
Hypoglycaemia 148.16 9.75 65 300734 116039 110172461
Back pain 148.09 9.75 515 300284 370481 109918019
Skin plaque 147.40 9.75 177 300622 12468 110276032
Parvovirus B19 infection 144.92 9.75 93 300706 2788 110285712
Hospitalisation 144.28 9.75 106 300693 142387 110146113
Psoriasis 144.19 9.75 757 300042 139236 110149264
Joint range of motion decreased 143.58 9.75 76 300723 121756 110166744
Bacterial sepsis 143.50 9.75 159 300640 10267 110278233
Hepatitis C 143.31 9.75 174 300625 12399 110276101
Leukaemia recurrent 142.66 9.75 95 300704 3036 110285464
Delirium 141.24 9.75 97 300702 134928 110153572
Alanine aminotransferase increased 140.79 9.75 919 299880 182854 110105646
Lactic acidosis 140.68 9.75 39 300760 92772 110195728
Engraft failure 139.35 9.75 60 300739 766 110287734
Renal tubular injury 138.48 9.75 93 300706 3015 110285485
Chorioretinopathy 138.01 9.75 83 300716 2212 110286288
Arthralgia 137.65 9.75 1406 299393 778226 109510274
Lymphocele 137.29 9.75 77 300722 1794 110286706
Progressive multifocal leukoencephalopathy 136.11 9.75 244 300555 24712 110263788
Deep vein thrombosis postoperative 135.56 9.75 6 300793 59285 110229215
Dyspepsia 135.52 9.75 193 300606 190772 110097728
Chronic obstructive pulmonary disease 134.79 9.75 64 300735 109094 110179406
Pathogen resistance 134.68 9.75 201 300598 17471 110271029
Peripheral venous disease 133.91 9.75 32 300767 84085 110204415
Renal tubular atrophy 133.48 9.75 81 300718 2195 110286305
Hirsutism 133.30 9.75 74 300725 1689 110286811
Lower limb fracture 131.69 9.75 23 300776 75325 110213175
Tongue disorder 131.67 9.75 178 300621 14120 110274380
Pneumomediastinum 130.79 9.75 109 300690 4927 110283573
Rectal haemorrhage 128.14 9.75 84 300715 119749 110168751
Overdose 128.10 9.75 278 300521 233516 110054984
Pneumatosis intestinalis 127.74 9.75 136 300663 8393 110280107
Haemolytic uraemic syndrome 127.61 9.75 107 300692 4878 110283622
Coombs positive haemolytic anaemia 126.98 9.75 69 300730 1508 110286992
Blood cholesterol increased 126.97 9.75 191 300608 184594 110103906
Pseudomonal sepsis 124.58 9.75 138 300661 8908 110279592
Mobility decreased 123.82 9.75 290 300509 237132 110051368
Demyelination 123.28 9.75 140 300659 9289 110279211
Pneumonia fungal 122.88 9.75 175 300624 14579 110273921
Cerebrovascular accident 122.04 9.75 190 300609 181094 110107406
Scleral hyperaemia 120.80 9.75 42 300757 285 110288215
Red blood cell sedimentation rate 119.41 9.75 105 300694 5109 110283391
Hypertrichosis 119.25 9.75 69 300730 1709 110286791
Ototoxicity 119.05 9.75 95 300704 4036 110284464
Squamous cell carcinoma of skin 118.90 9.75 187 300612 17016 110271484
Cerebral toxoplasmosis 118.82 9.75 85 300714 3057 110285443
Lymphoid tissue hypoplasia 118.05 9.75 67 300732 1598 110286902
Cardio-respiratory arrest 117.49 9.75 86 300713 115750 110172750
Intentional product misuse 117.19 9.75 113 300686 132791 110155709
Acute respiratory distress syndrome 116.57 9.75 364 300435 52834 110235666
Engraftment syndrome 116.51 9.75 70 300729 1862 110286638
Escherichia infection 116.26 9.75 222 300577 23594 110264906
Sinusitis 116.25 9.75 415 300384 296273 109992227
Sedation 115.98 9.75 24 300775 69659 110218841
Injection site pain 115.51 9.75 191 300608 177731 110110769
Nephrotic syndrome 115.11 9.75 164 300635 13667 110274833
Pyrexia 115.11 9.75 3227 297572 895038 109393462
Staphylococcal bacteraemia 114.78 9.75 181 300618 16507 110271993
Malignant neoplasm progression 114.64 9.75 186 300613 174381 110114119
Thymus hypoplasia 114.56 9.75 66 300733 1621 110286879
Lymphadenopathy 114.29 9.75 408 300391 63427 110225073
Candida infection 114.11 9.75 338 300461 47671 110240829
Blood lactate dehydrogenase increased 113.94 9.75 321 300478 44013 110244487
Graft versus host disease in eye 113.90 9.75 44 300755 416 110288084
Epstein-Barr virus associated lymphoma 112.51 9.75 65 300734 1605 110286895
Infusion related reaction 112.24 9.75 594 300205 380568 109907932
Grip strength decreased 112.00 9.75 39 300760 80135 110208365
Cardiac failure congestive 111.77 9.75 148 300651 150852 110137648
Elbow deformity 110.41 9.75 62 300737 1448 110287052
Joint swelling 109.82 9.75 729 300070 442116 109846384
Opportunistic infection 109.70 9.75 85 300714 3458 110285042
Leukopenia 109.67 9.75 737 300062 148054 110140446
Cryptococcosis 109.55 9.75 95 300704 4536 110283964
Infection reactivation 109.47 9.75 90 300709 3991 110284509
Systemic candida 108.78 9.75 135 300664 9839 110278661
Diabetes mellitus 108.30 9.75 546 300253 98835 110189665
Systemic mycosis 108.10 9.75 87 300712 3742 110284758
Autoimmune haemolytic anaemia 107.27 9.75 138 300661 10429 110278071
Mycobacterium chelonae infection 107.11 9.75 79 300720 2981 110285519
Wound infection 106.74 9.75 65 300734 96400 110192100
Aspartate aminotransferase increased 106.60 9.75 773 300026 159163 110129337
Rheumatoid factor positive 105.88 9.75 121 300678 131519 110156981
Human polyomavirus infection 105.35 9.75 64 300735 1738 110286762
Obesity 105.13 9.75 92 300707 113259 110175241
Dislocation of vertebra 104.90 9.75 3 300796 43718 110244782
Liver function test abnormal 104.65 9.75 418 300381 68532 110219968
Scedosporium infection 103.45 9.75 71 300728 2387 110286113
Skin mass 102.49 9.75 130 300669 9686 110278814
Herpes zoster 102.09 9.75 572 300227 107807 110180693
Live birth 102.00 9.75 31 300768 69453 110219047
Stem cell transplant 101.08 9.75 89 300710 4338 110284162
Disseminated tuberculosis 100.94 9.75 95 300704 5051 110283449
Chronic graft versus host disease oral 100.73 9.75 41 300758 450 110288050
Thrombotic thrombocytopenic purpura 100.56 9.75 110 300689 7001 110281499
Arthropathy 100.55 9.75 421 300378 287101 110001399
Haemodialysis 100.18 9.75 176 300623 17543 110270957
Flushing 99.59 9.75 83 300716 104653 110183847
Diarrhoea 99.32 9.75 2352 298447 1137153 109151347
Mycobacterial infection 99.25 9.75 88 300711 4329 110284171
Balance disorder 98.31 9.75 103 300696 116457 110172043
Brain abscess 97.91 9.75 106 300693 6668 110281832
Frequent bowel movements 97.55 9.75 36 300763 71354 110217146
Bone marrow failure 97.04 9.75 362 300437 57486 110231014
Headache 97.02 9.75 1753 299046 880624 109407876
International normalised ratio increased 96.67 9.75 58 300741 86714 110201786
Migraine 96.61 9.75 201 300598 171451 110117049
Toxoplasmosis 96.59 9.75 76 300723 3163 110285337
Herpes virus infection 95.95 9.75 118 300681 8520 110279980
Chronic graft versus host disease in eye 95.88 9.75 38 300761 387 110288113
Staphylococcal sepsis 95.63 9.75 171 300628 17283 110271217
Intentional product use issue 95.62 9.75 349 300450 247557 110040943
Liver injury 95.30 9.75 164 300635 150249 110138251
Enterococcal sepsis 95.09 9.75 76 300723 3236 110285264
Idiopathic pneumonia syndrome 94.98 9.75 47 300752 840 110287660
Pulmonary embolism 94.36 9.75 285 300514 214189 110074311
Maternal exposure during pregnancy 94.30 9.75 365 300434 254518 110033982
Insomnia 94.27 9.75 584 300215 360006 109928494
Myopathy 93.93 9.75 209 300590 24751 110263749
Pulmonary tuberculosis 93.79 9.75 120 300679 9019 110279481
Cushingoid 93.27 9.75 136 300663 11576 110276924
Bacillary angiomatosis 93.22 9.75 36 300763 340 110288160
Red blood cell sedimentation rate increased 93.05 9.75 441 300358 77861 110210639
Autoimmune disorder 92.95 9.75 31 300768 65452 110223048
Lymphopenia 92.80 9.75 280 300519 39890 110248610
Adjustment disorder with depressed mood 92.53 9.75 7 300792 43876 110244624
Oedema peripheral 92.43 9.75 520 300279 328140 109960360
Nail disorder 92.30 9.75 22 300777 57913 110230587
Gastroenteritis rotavirus 92.29 9.75 41 300758 567 110287933
Glomerulonephritis 92.16 9.75 87 300712 4643 110283857
Blood iron abnormal 92.02 9.75 55 300744 1449 110287051
Actinic keratosis 91.47 9.75 104 300695 6909 110281591
Orthostatic hypotension 91.21 9.75 33 300766 66216 110222284
Osteoarthritis 90.53 9.75 229 300570 182394 110106106
Osteonecrosis 90.35 9.75 248 300551 33493 110255007
Chest discomfort 90.10 9.75 213 300586 173635 110114865
Serum sickness 89.62 9.75 83 300716 4323 110284177
Glomerulosclerosis 89.50 9.75 51 300748 1226 110287274
Lung infiltration 89.09 9.75 203 300596 24425 110264075
Medication error 88.99 9.75 93 300706 105273 110183227
Tendonitis 88.87 9.75 210 300589 25873 110262627
Rash 88.65 9.75 1636 299163 819328 109469172
Complications of transplanted heart 88.65 9.75 37 300762 435 110288065
Rhabdomyolysis 88.49 9.75 596 300203 119805 110168695
Renal tubular necrosis 87.65 9.75 230 300569 30245 110258255
Graft loss 87.64 9.75 51 300748 1277 110287223
Serotonin syndrome 87.54 9.75 26 300773 59127 110229373
American trypanosomiasis 87.49 9.75 40 300759 594 110287906
Blepharospasm 87.05 9.75 21 300778 54830 110233670
Glomerulonephritis membranous 87.01 9.75 59 300740 1944 110286556
Eye discharge 86.79 9.75 113 300686 8641 110279859
X-ray abnormal 86.67 9.75 4 300795 38113 110250387
Atrial fibrillation 86.14 9.75 327 300472 229315 110059185
Peripheral swelling 85.32 9.75 696 300103 403338 109885162
Suicidal ideation 85.01 9.75 78 300721 93859 110194641
Bronchiolitis obliterans syndrome 84.25 9.75 40 300759 650 110287850
Leukoencephalopathy 83.95 9.75 114 300685 9081 110279419
Hyperplasia 83.86 9.75 52 300747 1466 110287034
Knee arthroplasty 83.42 9.75 36 300763 64912 110223588
End stage renal disease 83.29 9.75 182 300617 21291 110267209
Red blood cell schistocytes present 82.99 9.75 41 300758 730 110287770
Blood stem cell transplant failure 82.74 9.75 40 300759 678 110287822
Acute lymphocytic leukaemia recurrent 82.67 9.75 90 300709 5697 110282803
Fusarium infection 82.59 9.75 65 300734 2706 110285794
Agitation 82.44 9.75 112 300687 112939 110175561
Drug level increased 82.03 9.75 301 300498 47418 110241082
Impaired gastric emptying 81.81 9.75 137 300662 13138 110275362
Taste disorder 81.24 9.75 38 300761 65349 110223151
Coeliac disease 80.44 9.75 11 300788 43176 110245324
Disseminated aspergillosis 80.07 9.75 61 300738 2419 110286081
Gait inability 79.89 9.75 156 300643 136220 110152280
Rebound effect 79.77 9.75 144 300655 14662 110273838
Lymphadenitis 79.47 9.75 86 300713 5407 110283093
Serum ferritin increased 79.42 9.75 127 300672 11720 110276780
Pulmonary nocardiosis 79.07 9.75 62 300737 2567 110285933
Osteonecrosis of jaw 78.96 9.75 17 300782 48000 110240500
Enterobacter infection 78.91 9.75 88 300711 5723 110282777
Adenovirus reactivation 78.61 9.75 39 300760 701 110287799
Amnesia 78.32 9.75 103 300696 105305 110183195
Musculoskeletal pain 77.11 9.75 248 300551 182775 110105725
Papilloma viral infection 76.65 9.75 56 300743 2082 110286418
Hair follicle tumour benign 76.52 9.75 33 300766 423 110288077
Microangiopathy 76.51 9.75 64 300735 2908 110285592
Protothecosis 76.41 9.75 35 300764 522 110287978
Human herpesvirus 8 infection 76.28 9.75 53 300746 1818 110286682
Oxygen saturation decreased 76.15 9.75 199 300600 156783 110131717
Onychomadesis 75.43 9.75 16 300783 45647 110242853
Paroxysmal nocturnal haemoglobinuria 75.35 9.75 32 300767 394 110288106
Injection site erythema 75.25 9.75 87 300712 94089 110194411
Mycoplasma infection 74.99 9.75 47 300752 1351 110287149
Stenotrophomonas infection 74.93 9.75 86 300713 5772 110282728
Gait disturbance 74.56 9.75 447 300352 277761 110010739
Cardiac arrest 74.54 9.75 279 300520 196474 110092026
Urinary retention 74.28 9.75 49 300750 69634 110218866
Splenomegaly 73.66 9.75 188 300611 24310 110264190
Growth retardation 73.60 9.75 59 300740 2523 110285977
Toxic leukoencephalopathy 73.52 9.75 49 300750 1568 110286932
Erythrodermic psoriasis 72.86 9.75 53 300746 1957 110286543
Product quality issue 72.58 9.75 62 300737 77237 110211263
Lymphocytic infiltration 72.51 9.75 53 300746 1972 110286528
Complications of transplanted lung 71.88 9.75 36 300763 661 110287839
Haemosiderosis 71.75 9.75 34 300765 550 110287950
Pulmonary haemorrhage 71.39 9.75 146 300653 16310 110272190
Transaminases increased 70.98 9.75 351 300448 63039 110225461
Multiple sclerosis relapse 70.93 9.75 24 300775 50216 110238284
Gastroenteritis astroviral 70.75 9.75 25 300774 179 110288321
Tachycardia 70.75 9.75 346 300453 226299 110062201
Loss of consciousness 70.12 9.75 285 300514 196021 110092479
Lacrimation increased 69.87 9.75 214 300585 30736 110257764
Generalised oedema 69.04 9.75 212 300587 30492 110258008
Full blood count abnormal 68.98 9.75 33 300766 56019 110232481
Hepatitis B 68.54 9.75 106 300693 9506 110278994
Therapy partial responder 68.16 9.75 239 300560 36822 110251678
Complications of transplant surgery 68.10 9.75 36 300763 743 110287757
Mycobacterium haemophilum infection 67.92 9.75 35 300764 684 110287816
Haptoglobin decreased 67.91 9.75 48 300751 1693 110286807
Underdose 67.33 9.75 45 300754 63509 110224991
Disseminated intravascular coagulation 67.28 9.75 256 300543 41030 110247470
Abdominal distension 67.18 9.75 247 300552 174856 110113644
Toxicity to various agents 67.11 9.75 912 299887 479643 109808857
Transient ischaemic attack 66.85 9.75 46 300753 63936 110224564
Plasmablastic lymphoma 66.78 9.75 36 300763 774 110287726
C-reactive protein 66.40 9.75 4 300795 30327 110258173
Scleroderma 66.24 9.75 84 300715 6257 110282243
Pneumonia bacterial 65.39 9.75 188 300611 26073 110262427
Pyogenic granuloma 64.84 9.75 31 300768 512 110287988
Myocardial infarction 64.83 9.75 285 300514 191798 110096702
Atypical mycobacterial infection 64.79 9.75 56 300743 2662 110285838
Poikiloderma 64.64 9.75 30 300769 462 110288038
Back injury 64.59 9.75 24 300775 47375 110241125
Pregnancy 64.49 9.75 29 300770 51038 110237462
Acinetobacter infection 64.48 9.75 63 300736 3510 110284990
Device dislocation 64.25 9.75 6 300793 31698 110256802
Sopor 64.20 9.75 11 300788 36535 110251965
Clear cell renal cell carcinoma 64.11 9.75 56 300743 2700 110285800
Viral test positive 64.06 9.75 36 300763 842 110287658
Renal cell carcinoma 63.72 9.75 90 300709 7440 110281060
Poisoning 63.23 9.75 4 300795 29101 110259399
Human herpesvirus 6 infection reactivation 63.20 9.75 39 300760 1090 110287410
Microangiopathic haemolytic anaemia 63.19 9.75 48 300751 1895 110286605
Graft complication 63.10 9.75 39 300760 1093 110287407
Hepatitis E 63.10 9.75 69 300730 4390 110284110
Pneumonia adenoviral 62.91 9.75 32 300767 608 110287892
Product container issue 62.65 9.75 44 300755 1536 110286964
Device expulsion 62.20 9.75 6 300793 30885 110257615
Pneumocystis jirovecii infection 62.11 9.75 68 300731 4332 110284168
Reticulocyte count increased 62.00 9.75 44 300755 1562 110286938
Weight decreased 61.90 9.75 898 299901 467159 109821341
Viral infection 61.48 9.75 297 300502 52842 110235658
Encephalitis 61.30 9.75 149 300650 18690 110269810
B-cell lymphoma 61.27 9.75 86 300713 7068 110281432
Muscle spasms 61.07 9.75 474 300325 277683 110010817
Iron overload 60.99 9.75 49 300750 2102 110286398
Sleep disorder due to a general medical condition 60.67 9.75 33 300766 52079 110236421
Cytokine release syndrome 60.56 9.75 61 300738 70245 110218255
Hepatosplenomegaly 60.48 9.75 84 300715 6835 110281665
Meningoencephalitis herpetic 60.34 9.75 51 300748 2351 110286149
Lupus vulgaris 59.96 9.75 10 300789 33873 110254627
Granuloma 59.90 9.75 99 300700 9391 110279109
Disseminated cryptococcosis 59.83 9.75 53 300746 2604 110285896
Presyncope 59.83 9.75 29 300770 48858 110239642
Alternaria infection 59.31 9.75 36 300763 976 110287524
Chronic kidney disease 59.29 9.75 383 300416 75908 110212592
Post transplant distal limb syndrome 58.47 9.75 34 300765 850 110287650
Cough 58.17 9.75 894 299905 460747 109827753
Capillary leak syndrome 57.70 9.75 69 300730 4839 110283661
Unresponsive to stimuli 57.68 9.75 53 300746 63737 110224763
Rhinovirus infection 57.67 9.75 110 300689 11679 110276821
Superficial injury of eye 56.99 9.75 26 300773 384 110288116
Exostosis 56.64 9.75 27 300772 45929 110242571
Feeling hot 56.19 9.75 101 300698 91005 110197495
Erythema of eyelid 56.13 9.75 61 300738 3854 110284646
Enterocolitis viral 55.94 9.75 33 300766 848 110287652
Finger deformity 55.90 9.75 11 300788 33081 110255419
Bone marrow transplant rejection 55.84 9.75 24 300775 305 110288195
Hyperbilirubinaemia 55.72 9.75 197 300602 30474 110258026
Blood glucose increased 55.48 9.75 180 300619 132316 110156184
Blood urea increased 55.06 9.75 295 300504 54662 110233838
Herpes simplex pneumonia 54.88 9.75 25 300774 368 110288132
Adenoviral haemorrhagic cystitis 54.87 9.75 30 300769 664 110287836
Concomitant disease progression 54.84 9.75 58 300741 3552 110284948
Dermatitis exfoliative generalised 54.45 9.75 103 300696 10869 110277631
Hepatosplenic T-cell lymphoma 54.38 9.75 34 300765 973 110287527
Biopsy kidney abnormal 53.94 9.75 20 300779 167 110288333
Steroid diabetes 53.94 9.75 69 300730 5185 110283315
Blood potassium decreased 53.80 9.75 41 300758 54073 110234427
Tongue ulceration 53.77 9.75 66 300733 4756 110283744
Intracranial pressure increased 53.65 9.75 100 300699 10435 110278065
Device related infection 53.24 9.75 231 300568 39288 110249212
Chimerism 53.11 9.75 23 300776 298 110288202
Blindness cortical 53.07 9.75 35 300764 1100 110287400
Cytomegalovirus syndrome 52.97 9.75 23 300776 300 110288200
Acute kidney injury 52.94 9.75 2172 298627 633258 109655242
Fluid retention 52.57 9.75 111 300688 94196 110194304
Epstein-Barr virus antibody positive 52.27 9.75 29 300770 661 110287839
Fungal endocarditis 52.26 9.75 31 300768 805 110287695
Angiocentric lymphoma 52.17 9.75 36 300763 1221 110287279
Secondary immunodeficiency 52.14 9.75 64 300735 4612 110283888
Exposure during pregnancy 52.01 9.75 256 300543 167168 110121332
Musculoskeletal stiffness 51.98 9.75 498 300301 279324 110009176
Anuria 51.90 9.75 165 300634 24176 110264324
Rotavirus infection 51.83 9.75 32 300767 895 110287605
Tularaemia 51.78 9.75 20 300779 189 110288311
Adenoviral hepatitis 51.73 9.75 33 300766 979 110287521
Life support 51.70 9.75 25 300774 424 110288076
Escherichia sepsis 51.68 9.75 97 300702 10175 110278325
Autoimmune neutropenia 51.46 9.75 29 300770 682 110287818
Epidermodysplasia verruciformis 51.38 9.75 25 300774 430 110288070
Feeling abnormal 51.27 9.75 285 300514 180426 110108074
Lactobacillus infection 51.11 9.75 26 300773 494 110288006
CSF protein increased 51.08 9.75 38 300761 1453 110287047
Guillain-Barre syndrome 51.03 9.75 99 300700 10645 110277855
Intentional self-injury 50.92 9.75 19 300780 37410 110251090
Apoptosis 50.90 9.75 29 300770 697 110287803
Clostridium difficile colitis 50.87 9.75 245 300554 43533 110244967
Mycobacterium kansasii infection 50.77 9.75 24 300775 386 110288114
C-reactive protein increased 50.72 9.75 854 299945 217065 110071435
Drug withdrawal syndrome 50.64 9.75 20 300779 38034 110250466
Respiratory tract infection fungal 50.48 9.75 36 300763 1288 110287212
Haemolytic anaemia 50.39 9.75 148 300651 20772 110267728
Nephrectomy 50.37 9.75 48 300751 2592 110285908
Vertigo 50.33 9.75 100 300699 86770 110201730
Aggression 50.29 9.75 52 300747 59158 110229342
Swollen tongue 50.16 9.75 54 300745 60308 110228192
Microsporidia infection 50.03 9.75 37 300762 1402 110287098
Klebsiella sepsis 49.83 9.75 59 300740 4094 110284406
Hip arthroplasty 49.72 9.75 47 300752 55766 110232734
Neoplasm skin 49.60 9.75 52 300747 3152 110285348
Dilatation intrahepatic duct acquired 49.44 9.75 30 300769 813 110287687
Restlessness 49.39 9.75 48 300751 56211 110232289
Neuropathy peripheral 49.10 9.75 286 300513 178991 110109509
Visual acuity reduced 48.77 9.75 195 300604 31978 110256522
Injection site reaction 48.68 9.75 106 300693 88964 110199536
Joint stiffness 48.64 9.75 67 300732 67176 110221324
Hepatic failure 48.55 9.75 337 300462 68402 110220098
Porokeratosis 48.50 9.75 21 300778 272 110288228
Chronic myeloid leukaemia 48.48 9.75 59 300740 4214 110284286
Fear of injection 48.43 9.75 87 300712 8824 110279676
Product administered to patient of inappropriate age 48.28 9.75 82 300717 7954 110280546
Deep vein thrombosis 48.14 9.75 206 300593 139681 110148819
Adverse drug reaction 48.05 9.75 138 300661 105421 110183079
Enterococcal bacteraemia 48.04 9.75 60 300739 4401 110284099
Immunosuppression 48.01 9.75 131 300668 17628 110270872
Trichophytic granuloma 47.82 9.75 14 300785 49 110288451
Nightmare 47.64 9.75 23 300776 38840 110249660
Head injury 47.57 9.75 29 300770 42988 110245512
Human herpesvirus 6 encephalitis 47.52 9.75 32 300767 1042 110287458
Dysgeusia 47.41 9.75 73 300726 69912 110218588
Hypocalcaemia 47.41 9.75 65 300734 65301 110223199
Coronary artery disease 47.41 9.75 76 300723 71614 110216886
Renal disorder 47.15 9.75 262 300537 49217 110239283
Ventricular tachycardia 47.08 9.75 40 300759 49969 110238531
Diabetic ketoacidosis 47 9.75 28 300771 42030 110246470
Necrosis 46.91 9.75 99 300700 11307 110277193
Lupus vasculitis 46.89 9.75 26 300773 592 110287908
Influenza like illness 46.86 9.75 107 300692 88305 110200195
Hepatic fibrosis 46.75 9.75 81 300718 7985 110280515
Gouty tophus 46.67 9.75 24 300775 467 110288033
Sebaceous hyperplasia 46.65 9.75 15 300784 77 110288423
Hypophosphataemia 46.58 9.75 16 300783 33166 110255334
Phaeohyphomycosis 46.39 9.75 38 300761 1676 110286824
Fungaemia 46.06 9.75 69 300730 6017 110282483
Human ehrlichiosis 45.97 9.75 27 300772 688 110287812
Brain oedema 45.96 9.75 187 300612 30911 110257589
Corneal endotheliitis 45.59 9.75 16 300783 112 110288388
Peripheral artery aneurysm 45.59 9.75 24 300775 491 110288009
Abdominal pain 45.55 9.75 1055 299744 511934 109776566
Acute myocardial infarction 45.54 9.75 100 300699 83677 110204823
Ureaplasma infection 45.51 9.75 36 300763 1510 110286990
Ventricular fibrillation 45.47 9.75 28 300771 41285 110247215
Drug reaction with eosinophilia and systemic symptoms 45.45 9.75 97 300702 81998 110206502
Nephropathy 45.42 9.75 108 300691 13359 110275141
Sinus tachycardia 45.15 9.75 33 300766 44460 110244040
Papilloedema 45.04 9.75 76 300723 7333 110281167
Dyskinesia 45.04 9.75 44 300755 51402 110237098
Sciatica 44.90 9.75 117 300682 92282 110196218
Renal lymphocele 44.88 9.75 16 300783 118 110288382
Heart rate decreased 44.80 9.75 99 300700 82657 110205843
IgA nephropathy 44.72 9.75 49 300750 3124 110285376
Coma 44.72 9.75 167 300632 117702 110170798
Plasmacytoma 44.68 9.75 63 300736 5199 110283301
Varicella 44.49 9.75 53 300746 3702 110284798
Hypoproteinaemia 44.42 9.75 67 300732 5878 110282622
Muscle spasticity 44.42 9.75 21 300778 35894 110252606
Oral lichen planus 44.35 9.75 29 300770 898 110287602
Gastrointestinal disorder 44.34 9.75 432 300367 241520 110046980
Therapy interrupted 44.33 9.75 42 300757 49780 110238720
Respiratory arrest 44.30 9.75 56 300743 58243 110230257
Laparotomy 44.27 9.75 24 300775 522 110287978
Cytogenetic abnormality 44.27 9.75 32 300767 1170 110287330
Skin neoplasm excision 44.26 9.75 40 300759 2018 110286482
Aplasia 44.25 9.75 78 300721 7795 110280705
Plasmodium falciparum infection 44.17 9.75 17 300782 159 110288341
Erythema 44.09 9.75 1071 299728 290376 109998124
Acute myeloid leukaemia 44.08 9.75 213 300586 37897 110250603
Pneumonia pseudomonal 44.02 9.75 76 300723 7470 110281030
Renal transplant 43.91 9.75 49 300750 3189 110285311
Haematochezia 43.62 9.75 164 300635 115360 110173140
Lymphadenectomy 43.57 9.75 35 300764 1501 110286999
Hepatic enzyme increased 43.32 9.75 613 300186 320279 109968221
Mechanical ventilation 43.06 9.75 49 300750 3258 110285242
Tuberculosis 43.05 9.75 126 300673 17648 110270852
Penicillium infection 42.96 9.75 25 300774 626 110287874
Laryngitis fungal 42.90 9.75 17 300782 173 110288327
Nephroureterectomy 42.71 9.75 10 300789 9 110288491
Heart rate irregular 42.45 9.75 20 300779 34254 110254246
Ureteric stenosis 42.38 9.75 35 300764 1562 110286938
Cytopenia 42.08 9.75 178 300621 29938 110258562
Malabsorption 41.87 9.75 68 300731 6357 110282143
Hepatitis B reactivation 41.87 9.75 74 300725 7410 110281090
Sinus bradycardia 41.77 9.75 14 300785 29469 110259031
Product label confusion 41.71 9.75 6 300793 22671 110265829
Alpha haemolytic streptococcal infection 41.40 9.75 50 300749 3543 110284957
Injection site pruritus 41.33 9.75 47 300752 51211 110237289
Diffuse alveolar damage 41.31 9.75 53 300746 3994 110284506
Immune thrombocytopenia 41.31 9.75 145 300654 22349 110266151
Tumour lysis syndrome 41.30 9.75 16 300783 30785 110257715
Legionella infection 41.15 9.75 28 300771 928 110287572
Walking aid user 40.98 9.75 9 300790 25066 110263434
Glomerulonephropathy 40.95 9.75 20 300779 347 110288153
Instillation site irritation 40.89 9.75 16 300783 157 110288343
Malacoplakia 40.87 9.75 31 300768 1221 110287279
Acute disseminated encephalomyelitis 40.82 9.75 21 300778 409 110288091
Reticulocytosis 40.71 9.75 24 300775 616 110287884
Ovarian failure 40.62 9.75 28 300771 948 110287552
Soft tissue disorder 40.54 9.75 49 300750 3475 110285025
Pneumonia viral 40.39 9.75 92 300707 11065 110277435
Rheumatoid lung 40.27 9.75 54 300745 4250 110284250
Vein rupture 40.24 9.75 42 300757 2533 110285967
Blood pressure fluctuation 40.11 9.75 90 300709 74734 110213766
Maternal exposure timing unspecified 39.98 9.75 5 300794 21008 110267492
Skin infection 39.54 9.75 143 300656 22366 110266134
Thrombocytopenia 39.47 9.75 1235 299564 347650 109940850
Papule 39.43 9.75 86 300713 10047 110278453
Glomerulonephritis membranoproliferative 39.23 9.75 26 300773 824 110287676
Fungal test positive 39.23 9.75 29 300770 1098 110287402
Bone marrow transplant 39.16 9.75 34 300765 1626 110286874
Empyema 39.12 9.75 61 300738 5509 110282991
Keratoacanthoma 38.98 9.75 32 300767 1416 110287084
Papilloma 38.98 9.75 22 300777 519 110287981
T-cell lymphoma 38.64 9.75 33 300766 1543 110286957
Ileal ulcer 38.46 9.75 35 300764 1782 110286718
Oliguria 38.44 9.75 125 300674 18532 110269968
Urine output decreased 38.13 9.75 130 300669 19746 110268754
Oral disorder 38.06 9.75 94 300705 11909 110276591
Diffuse large B-cell lymphoma stage IV 37.94 9.75 26 300773 872 110287628
Drug tolerance decreased 37.88 9.75 162 300637 27378 110261122
BK polyomavirus test positive 37.83 9.75 18 300781 294 110288206
Femur fracture 37.82 9.75 39 300760 44430 110244070
Hypercholesterolaemia 37.61 9.75 124 300675 90713 110197787
Laryngitis 37.45 9.75 36 300763 42375 110246125
Troponin increased 37.44 9.75 17 300782 29749 110258751
Acute graft versus host disease oral 37.42 9.75 13 300786 88 110288412
Onychomycosis 37.29 9.75 30 300769 38501 110249999
Cognitive disorder 37.25 9.75 118 300681 87393 110201107
Chronic sinusitis 37.16 9.75 11 300788 25073 110263427
Unevaluable event 37.12 9.75 65 300734 59162 110229338
Cytomegalovirus enterocolitis 37.08 9.75 38 300761 2243 110286257
Heart rate increased 37.00 9.75 234 300565 143600 110144900
Device difficult to use 36.96 9.75 4 300795 18801 110269699
Neutrophil count decreased 36.94 9.75 186 300613 120755 110167745
Brain stem syndrome 36.90 9.75 30 300769 1309 110287191
Eyelid oedema 36.78 9.75 108 300691 15154 110273346
Abnormal sensation in eye 36.59 9.75 37 300762 2149 110286351
Endocarditis 36.52 9.75 99 300700 13272 110275228
Pallor 36.28 9.75 61 300738 56406 110232094
Morphoea 36.26 9.75 22 300777 596 110287904
Central nervous system fungal infection 36.16 9.75 22 300777 599 110287901
Accidental overdose 36.15 9.75 53 300746 51781 110236719
Mucoepidermoid carcinoma of salivary gland 36.09 9.75 14 300785 134 110288366
Oral lichenoid reaction 36.04 9.75 15 300784 175 110288325
Dyspnoea exertional 35.95 9.75 153 300646 103907 110184593
Hiatus hernia 35.93 9.75 15 300784 27591 110260909
Fungal sepsis 35.88 9.75 37 300762 2200 110286300
Drug level fluctuating 35.72 9.75 26 300773 961 110287539
Chronic spontaneous urticaria 35.70 9.75 35 300764 1958 110286542
Fibroadenoma of breast 35.65 9.75 23 300776 696 110287804
Pigmentation disorder 35.50 9.75 68 300731 7243 110281257
Schizophrenia 35.34 9.75 8 300791 21818 110266682
Cutaneous T-cell lymphoma stage IV 35.30 9.75 11 300788 50 110288450
Procedural pain 35.29 9.75 27 300772 35538 110252962
Haematuria 35.19 9.75 363 300436 82642 110205858
Clonal evolution 35.09 9.75 16 300783 236 110288264
Epstein-Barr virus test positive 35.06 9.75 29 300770 1297 110287203
Cat scratch disease 34.84 9.75 22 300777 641 110287859
Epilepsy 34.83 9.75 147 300652 100062 110188438
Complications of transplanted liver 34.68 9.75 20 300779 492 110288008
Transitional cell carcinoma 34.67 9.75 43 300756 3132 110285368
Idiopathic intracranial hypertension 34.58 9.75 48 300751 3904 110284596
Pulmonary alveolar haemorrhage 34.54 9.75 127 300672 20023 110268477
Respiratory distress 34.51 9.75 312 300487 68562 110219938
Hallucination 34.51 9.75 150 300649 101282 110187218
Dry eye 34.50 9.75 265 300534 55528 110232972
Vulvovaginal erythema 34.50 9.75 20 300779 497 110288003
Leukaemia in remission 34.35 9.75 9 300790 18 110288482
Streptococcal infection 34.23 9.75 85 300714 10805 110277695
Weight fluctuation 34.13 9.75 9 300790 22136 110266364
Chromophobe renal cell carcinoma 33.97 9.75 11 300788 58 110288442
Disability 33.94 9.75 20 300779 30203 110258297
Demyelinating polyneuropathy 33.93 9.75 36 300763 2213 110286287
Erectile dysfunction 33.92 9.75 5 300794 18551 110269949
Infertility 33.89 9.75 23 300776 759 110287741
Pneumonia klebsiella 33.83 9.75 63 300736 6569 110281931
Arteriosclerosis coronary artery 33.76 9.75 13 300786 25105 110263395
Bile duct stenosis 33.75 9.75 39 300760 2637 110285863
Laser therapy 33.71 9.75 9 300790 20 110288480
Cytomegalovirus enteritis 33.68 9.75 26 300773 1052 110287448
Drug intolerance 33.67 9.75 1389 299410 405123 109883377
Neoplasm progression 33.57 9.75 79 300720 64516 110223984
Withdrawal syndrome 33.53 9.75 22 300777 31358 110257142
Respiratory depression 33.44 9.75 23 300776 31978 110256522
Behcet's syndrome 33.41 9.75 9 300790 21 110288479
Impaired work ability 33.36 9.75 15 300784 26404 110262096
Peritonitis 33.32 9.75 176 300623 32431 110256069
Torsade de pointes 33.32 9.75 10 300789 22590 110265910
Therapeutic product effect variable 33.25 9.75 39 300760 2679 110285821
Pain in extremity 33.24 9.75 1040 299759 486078 109802422
Upper gastrointestinal haemorrhage 33.23 9.75 53 300746 50043 110238457
Venous injury 33.22 9.75 25 300774 973 110287527
Cytomegalovirus gastrointestinal infection 33.06 9.75 22 300777 702 110287798
Marrow hyperplasia 33.03 9.75 32 300767 1764 110286736
Blast crisis in myelogenous leukaemia 33 9.75 25 300774 983 110287517
Nephrolithiasis 32.82 9.75 83 300716 66129 110222371
Drug level decreased 32.72 9.75 118 300681 18430 110270070
Muscular weakness 32.70 9.75 477 300322 247991 110040509
Lethargy 32.69 9.75 137 300662 93439 110195061
Organising pneumonia 32.63 9.75 99 300700 14144 110274356
Gastrointestinal mucormycosis 32.60 9.75 22 300777 719 110287781
Sweat gland tumour 32.57 9.75 20 300779 554 110287946
Eosinophilia 32.45 9.75 68 300731 57868 110230632
Passenger lymphocyte syndrome 32.43 9.75 14 300785 180 110288320
Cardiac disorder 32.37 9.75 103 300696 76177 110212323
Drug dependence 32.17 9.75 54 300745 49966 110238534
Gastroenteritis adenovirus 32.03 9.75 18 300781 421 110288079
Productive cough 32.01 9.75 181 300618 114124 110174376
Gastrointestinal stromal tumour 31.95 9.75 34 300765 2097 110286403
Depressed mood 31.90 9.75 74 300725 60735 110227765
Haematemesis 31.76 9.75 71 300728 59037 110229463
Ankylosing spondylitis 31.63 9.75 104 300695 15508 110272992
Herpes zoster meningoencephalitis 31.51 9.75 25 300774 1053 110287447
Lupus nephritis 31.42 9.75 50 300749 4595 110283905
Obstructive airways disorder 31.39 9.75 48 300751 46101 110242399
Self-consciousness 31.36 9.75 14 300785 196 110288304
Pyelonephritis 31.30 9.75 144 300655 25106 110263394
Tuberculosis gastrointestinal 31.27 9.75 20 300779 596 110287904
Hypomagnesaemia 31.24 9.75 74 300725 60296 110228204
Swelling of eyelid 31.23 9.75 61 300738 6592 110281908
Cryptococcal meningoencephalitis 31.22 9.75 17 300782 373 110288127
Drug level changed 31.15 9.75 20 300779 600 110287900
Chronic inflammatory demyelinating polyradiculoneuropathy 31.12 9.75 34 300765 2161 110286339
Drug effective for unapproved indication 31.09 9.75 97 300702 14070 110274430
Osmotic demyelination syndrome 31.08 9.75 33 300766 2030 110286470
Stress 31.05 9.75 164 300635 105184 110183316
Bowen's disease 31.01 9.75 12 300787 114 110288386
Hypertensive encephalopathy 31.01 9.75 26 300773 1185 110287315
Adenomatous polyposis coli 30.99 9.75 16 300783 314 110288186
Blood calcium decreased 30.98 9.75 31 300768 35814 110252686
Anti-cyclic citrullinated peptide antibody 30.98 9.75 8 300791 19956 110268544
Myopathy toxic 30.98 9.75 27 300772 1298 110287202
West Nile viral infection 30.96 9.75 27 300772 1299 110287201
Angina pectoris 30.94 9.75 78 300721 62217 110226283
Eye pruritus 30.86 9.75 173 300626 32602 110255898
Cytomegalovirus hepatitis 30.84 9.75 23 300776 883 110287617
Central nervous system viral infection 30.81 9.75 16 300783 318 110288182
Laboratory test abnormal 30.81 9.75 45 300754 44034 110244466
Lichenification 30.79 9.75 24 300775 985 110287515
Retinal haemorrhage 30.76 9.75 75 300724 9426 110279074
Haemorrhage intracranial 30.73 9.75 158 300641 28811 110259689
Treatment noncompliance 30.66 9.75 99 300700 72891 110215609
Ophthalmic herpes simplex 30.66 9.75 23 300776 891 110287609
Haemorrhagic cyst 30.58 9.75 17 300782 389 110288111
Candida sepsis 30.58 9.75 39 300760 2922 110285578
Liver abscess 30.48 9.75 66 300733 7673 110280827
Anogenital warts 30.36 9.75 25 300774 1111 110287389
Blood pressure decreased 30.24 9.75 186 300613 114905 110173595
Biliary hamartoma 30.21 9.75 8 300791 17 110288483
Device leakage 30.09 9.75 4 300795 16044 110272456
Small intestinal obstruction 30.04 9.75 26 300773 32187 110256313
Transplant abscess 29.94 9.75 10 300789 59 110288441
Extrapyramidal disorder 29.83 9.75 21 300778 28846 110259654
Biphasic mesothelioma 29.80 9.75 10 300789 60 110288440
Faecaloma 29.74 9.75 3 300796 14905 110273595
Laryngeal disorder 29.66 9.75 25 300774 1148 110287352
Central nervous system vasculitis 29.54 9.75 29 300770 1625 110286875
Thrombosis 29.40 9.75 174 300625 108488 110180012
Disseminated mycobacterium avium complex infection 29.27 9.75 18 300781 500 110288000
Blood beta-D-glucan increased 29.19 9.75 21 300778 762 110287738
Renal arteriosclerosis 29.07 9.75 18 300781 506 110287994
Product delivery mechanism issue 28.97 9.75 14 300785 237 110288263
Peripheral T-cell lymphoma unspecified 28.95 9.75 22 300777 869 110287631
Pneumonia aspiration 28.95 9.75 118 300681 81115 110207385
Dysarthria 28.86 9.75 124 300675 83997 110204503
Retinopathy haemorrhagic 28.85 9.75 11 300788 100 110288400
Pseudomonas aeruginosa meningitis 28.85 9.75 11 300788 100 110288400
Non-Hodgkin's lymphoma 28.74 9.75 27 300772 1432 110287068
Hepatomegaly 28.71 9.75 125 300674 21289 110267211
Pruritus 28.68 9.75 1291 299508 580269 109708231
Escherichia urinary tract infection 28.67 9.75 103 300696 16059 110272441
Sleep apnoea syndrome 28.55 9.75 41 300758 40406 110248094
Skin papilloma 28.53 9.75 60 300739 6836 110281664
Renal vein thrombosis 28.49 9.75 24 300775 1101 110287399
Renal vessel disorder 28.49 9.75 15 300784 307 110288193
Herpes ophthalmic 28.43 9.75 30 300769 1832 110286668
B-cell aplasia 28.33 9.75 16 300783 378 110288122
Guttate psoriasis 28.24 9.75 18 300781 533 110287967
Chronic myeloid leukaemia recurrent 28.21 9.75 16 300783 381 110288119
Cutaneous mucormycosis 28.18 9.75 20 300779 710 110287790
Atrioventricular block first degree 28.02 9.75 3 300796 14222 110274278
Retinal scar 27.97 9.75 17 300782 462 110288038
Blood immunoglobulin M increased 27.94 9.75 28 300771 1609 110286891
Pyoderma gangrenosum 27.91 9.75 52 300747 5424 110283076
Aspergillus test positive 27.84 9.75 23 300776 1027 110287473
Meningitis cryptococcal 27.83 9.75 48 300751 4714 110283786
Trichophytosis 27.81 9.75 17 300782 467 110288033
Throat tightness 27.78 9.75 30 300769 33459 110255041
Removal of renal transplant 27.77 9.75 8 300791 26 110288474
Mouth ulceration 27.77 9.75 225 300574 47913 110240587
Lepromatous leprosy 27.76 9.75 11 300788 112 110288388
Irritability 27.72 9.75 55 300744 47754 110240746
Liver function test increased 27.72 9.75 135 300664 88413 110200087
Parvovirus infection 27.68 9.75 22 300777 929 110287571
Iris adhesions 27.65 9.75 19 300780 640 110287860
Eye infection toxoplasmal 27.46 9.75 20 300779 740 110287760
Vaccination failure 27.46 9.75 34 300765 2472 110286028
Arterial disorder 27.42 9.75 32 300767 2187 110286313
Gastroenteritis norovirus 27.41 9.75 41 300758 3570 110284930
New onset diabetes after transplantation 27.34 9.75 16 300783 405 110288095
Blood glucose decreased 27.25 9.75 24 300775 29464 110259036
Lupus-like syndrome 27.20 9.75 43 300756 40749 110247751
Hypothyroidism 27.19 9.75 104 300695 72795 110215705
Skin laceration 27.16 9.75 31 300768 33722 110254778
Instillation site reaction 27.03 9.75 15 300784 342 110288158
Tooth hypoplasia 27.03 9.75 15 300784 342 110288158
Benign prostatic hyperplasia 27.00 9.75 8 300791 18226 110270274
Infective pulmonary exacerbation of cystic fibrosis 26.95 9.75 4 300795 14767 110273733
Epicondylitis 26.88 9.75 34 300765 2526 110285974
Synovitis 26.79 9.75 555 300244 273537 110014963
Erythema infectiosum 26.75 9.75 13 300786 223 110288277
Herpes simplex reactivation 26.71 9.75 26 300773 1442 110287058
Central nervous system lesion 26.64 9.75 98 300701 15455 110273045
Papillary renal cell carcinoma 26.57 9.75 15 300784 354 110288146
Fear 26.54 9.75 15 300784 23178 110265322
Hydrocephalus 26.53 9.75 75 300724 10300 110278200
Vulvovaginal swelling 26.49 9.75 18 300781 595 110287905
Monkeypox 26.42 9.75 15 300784 358 110288142
Keratitis 26.41 9.75 49 300750 5095 110283405
Sinus disorder 26.40 9.75 30 300769 32698 110255802
NPM1 gene mutation 26.38 9.75 11 300788 129 110288371
Intussusception 26.34 9.75 27 300772 1594 110286906
Diarrhoea haemorrhagic 26.33 9.75 98 300701 15541 110272959
Drug interaction 26.31 9.75 1636 299163 498547 109789953
Bronchospasm 26.31 9.75 26 300773 30213 110258287
Visceral leishmaniasis 26.30 9.75 28 300771 1728 110286772
Cerebral fungal infection 26.25 9.75 19 300780 696 110287804
Abnormal behaviour 26.18 9.75 41 300758 38998 110249502
Cryptococcal cutaneous infection 26.14 9.75 14 300785 297 110288203
Skin disorder 26.08 9.75 203 300596 42710 110245790
Cytomegalovirus gastrointestinal ulcer 26.01 9.75 11 300788 134 110288366
Paraesthesia oral 25.94 9.75 32 300767 33639 110254861
Respiratory tract inflammation 25.90 9.75 22 300777 1021 110287479
Hypertension 25.85 9.75 1663 299136 508421 109780079
Deafness 25.83 9.75 142 300657 26567 110261933
Renal mass 25.80 9.75 40 300759 3595 110284905
Product dose omission in error 25.79 9.75 16 300783 23496 110265004
Infusion site reaction 25.75 9.75 8 300791 17674 110270826
Astrovirus test positive 25.74 9.75 8 300791 36 110288464
Retinitis 25.67 9.75 30 300769 32297 110256203
Philadelphia positive chronic myeloid leukaemia 25.67 9.75 12 300787 188 110288312
CSF white blood cell count increased 25.65 9.75 11 300788 139 110288361
Migraine with aura 25.59 9.75 39 300760 3453 110285047
Sleep disorder due to general medical condition, insomnia type 25.58 9.75 175 300624 105468 110183032
Chloroma 25.51 9.75 20 300779 828 110287672
Disseminated toxoplasmosis 25.49 9.75 16 300783 461 110288039
Myelodysplastic syndrome 25.43 9.75 182 300617 37302 110251198
Soft tissue infection 25.41 9.75 48 300751 5059 110283441
Parosmia 25.41 9.75 3 300796 13177 110275323
Middle insomnia 25.33 9.75 12 300787 20490 110268010
Drug hypersensitivity 25.33 9.75 994 299805 453096 109835404
Pneumonia herpes viral 25.33 9.75 12 300787 194 110288306
Tremor 25.31 9.75 392 300407 201840 110086660
Angiosarcoma 25.29 9.75 17 300782 552 110287948
Encephalitis fungal 25.28 9.75 13 300786 253 110288247
Haematotoxicity 25.23 9.75 119 300680 20963 110267537
Stress cardiomyopathy 25.18 9.75 6 300793 15800 110272700
Glomerulonephritis minimal lesion 25.04 9.75 22 300777 1069 110287431
Ear infection 25.04 9.75 87 300712 62645 110225855
Rash pruritic 24.91 9.75 390 300409 97679 110190821
Laryngitis viral 24.83 9.75 9 300790 70 110288430
Immune effector cell-associated neurotoxicity syndrome 24.79 9.75 5 300794 14777 110273723
Malignant neoplasm of conjunctiva 24.72 9.75 9 300790 71 110288429
Red blood cell abnormality 24.69 9.75 20 300779 868 110287632
Glomerulonephritis proliferative 24.69 9.75 16 300783 488 110288012
Concomitant disease aggravated 24.66 9.75 99 300700 16265 110272235
Splenic abscess 24.64 9.75 21 300778 979 110287521
Infective tenosynovitis 24.60 9.75 16 300783 491 110288009
Renal tubular disorder 24.43 9.75 59 300740 7370 110281130
Endocrine ophthalmopathy 24.39 9.75 24 300775 1349 110287151
Device issue 24.39 9.75 35 300764 34500 110254000
Hepatic artery stenosis 24.22 9.75 13 300786 277 110288223
Nasal congestion 24.20 9.75 162 300637 98120 110190380
Jaw fracture 24.20 9.75 36 300763 3120 110285380
Limbic encephalitis 24.18 9.75 19 300780 789 110287711
Drug dose omission by device 24.15 9.75 5 300794 14511 110273989
Tinnitus 24.14 9.75 84 300715 60456 110228044
Oesophageal squamous cell carcinoma 24.12 9.75 16 300783 508 110287992
Periorbital infection 24.08 9.75 11 300788 163 110288337
Restless legs syndrome 24.05 9.75 19 300780 24607 110263893
Tardive dyskinesia 24.05 9.75 4 300795 13575 110274925
Chemokine increased 24.02 9.75 7 300792 24 110288476
Colitis herpes 24.02 9.75 7 300792 24 110288476
Arterial occlusive disease 24.02 9.75 6 300793 15302 110273198
Psoriasis area severity index increased 24.01 9.75 13 300786 282 110288218
Reversible cerebral vasoconstriction syndrome 24.00 9.75 45 300754 4716 110283784
Congenital coronary artery malformation 24.00 9.75 10 300789 117 110288383
Endocarditis bacterial 23.94 9.75 27 300772 1778 110286722
Inflammatory myofibroblastic tumour 23.88 9.75 12 300787 222 110288278
Hemianopia 23.85 9.75 34 300765 2834 110285666
Atypical haemolytic uraemic syndrome 23.85 9.75 25 300774 1515 110286985
Sebaceous carcinoma 23.84 9.75 11 300788 167 110288333
Swelling face 23.84 9.75 150 300649 92171 110196329
Blood immunoglobulin A decreased 23.83 9.75 30 300769 2218 110286282
Rash pustular 23.82 9.75 83 300716 12746 110275754
Renal cell carcinoma stage I 23.78 9.75 9 300790 80 110288420
Eyelid disorder 23.77 9.75 31 300768 2374 110286126
White blood cell count decreased 23.76 9.75 460 300339 228930 110059570
Vision blurred 23.54 9.75 487 300312 128535 110159965
Blood immunoglobulin G decreased 23.53 9.75 48 300751 5352 110283148
Cutaneous sporotrichosis 23.49 9.75 9 300790 83 110288417
Squamous cell carcinoma of the oral cavity 23.49 9.75 18 300781 720 110287780
Raoultella ornithinolytica infection 23.44 9.75 11 300788 174 110288326
Cutaneous T-cell lymphoma refractory 23.38 9.75 7 300792 27 110288473
Tongue neoplasm 23.34 9.75 10 300789 126 110288374
Corynebacterium infection 23.32 9.75 28 300771 1972 110286528
Urinary incontinence 23.24 9.75 62 300737 48525 110239975
Lip ulceration 23.20 9.75 33 300766 2745 110285755
Vulvovaginal candidiasis 23.10 9.75 36 300763 3249 110285251
Rib fracture 23.09 9.75 35 300764 33735 110254765
Dysphonia 23.05 9.75 117 300682 75812 110212688
Biloma 23.04 9.75 12 300787 240 110288260
Debridement 23.01 9.75 27 300772 1856 110286644
Mycobacterium avium complex infection 23.01 9.75 50 300749 5827 110282673
Haemorrhagic diathesis 22.97 9.75 58 300741 7450 110281050
Limb injury 22.96 9.75 42 300757 37594 110250906
Therapeutic product effect incomplete 22.90 9.75 783 300016 223022 110065478
Toxic encephalopathy 22.89 9.75 92 300707 15122 110273378
Affect lability 22.89 9.75 11 300788 18626 110269874
Radiculopathy 22.86 9.75 12 300787 19324 110269176
Ulcerative keratitis 22.74 9.75 44 300755 4722 110283778
Mesangioproliferative glomerulonephritis 22.68 9.75 12 300787 248 110288252
Vanishing bile duct syndrome 22.68 9.75 35 300764 3133 110285367
Mantle cell lymphoma stage IV 22.67 9.75 8 300791 57 110288443
Hepatotoxicity 22.62 9.75 268 300531 63132 110225368
Vascular graft infection 22.58 9.75 6 300793 13 110288487
Coxsackie virus test positive 22.58 9.75 6 300793 13 110288487
Reticulocytopenia 22.54 9.75 13 300786 320 110288180
Perinephric collection 22.44 9.75 14 300785 399 110288101
Undifferentiated sarcoma 22.43 9.75 7 300792 32 110288468
Steroid dependence 22.42 9.75 62 300737 8407 110280093
Lung abscess 22.37 9.75 45 300754 4967 110283533
Urinary tract infection viral 22.34 9.75 9 300790 96 110288404
Disease progression 22.33 9.75 843 299956 243191 110045309
Lung consolidation 22.32 9.75 71 300728 10405 110278095
Anaphylactic shock 22.29 9.75 69 300730 51477 110237023
Atrioventricular block 22.24 9.75 9 300790 16868 110271632
Incorrect route of product administration 22.24 9.75 94 300705 63967 110224533
Cryptosporidiosis infection 22.23 9.75 21 300778 1122 110287378
Hypoalbuminaemia 22.22 9.75 145 300654 28829 110259671
Gastropleural fistula 22.21 9.75 8 300791 61 110288439
Dermatitis atopic 22.21 9.75 132 300667 25409 110263091
Serratia infection 22.15 9.75 29 300770 2230 110286270
Prostate cancer 22.09 9.75 43 300756 37598 110250902
T-cell type acute leukaemia 21.94 9.75 13 300786 337 110288163
Squamous cell carcinoma of the tongue 21.92 9.75 18 300781 797 110287703
Injection site papule 21.88 9.75 20 300779 1024 110287476
Device occlusion 21.88 9.75 7 300792 15178 110273322
Adrenal suppression 21.86 9.75 25 300774 1671 110286829
Injection site warmth 21.80 9.75 10 300789 17395 110271105
Dermatitis 21.78 9.75 140 300659 27697 110260803
Anaplastic large cell lymphoma T- and null-cell types 21.77 9.75 11 300788 206 110288294
Intervertebral disc degeneration 21.72 9.75 11 300788 18074 110270426
Skin toxicity 21.68 9.75 76 300723 11707 110276793
Gingival swelling 21.61 9.75 46 300753 5284 110283216
Foot deformity 21.61 9.75 64 300735 48416 110240084
Lung disorder 21.52 9.75 352 300447 179695 110108805
Disturbance in attention 21.50 9.75 91 300708 61904 110226596
Ewing's sarcoma recurrent 21.44 9.75 6 300793 17 110288483
Lymphoma 21.39 9.75 110 300689 20061 110268439
Respiratory syncytial virus infection 21.33 9.75 87 300712 14397 110274103
Ulcer haemorrhage 21.31 9.75 18 300781 22553 110265947
Fibrosis 21.29 9.75 57 300742 7585 110280915
Device related sepsis 21.27 9.75 57 300742 7590 110280910
Weber tuning fork test abnormal 21.25 9.75 9 300790 110 110288390
Reticulocyte count decreased 21.22 9.75 19 300780 947 110287553
Azotaemia 21.17 9.75 68 300731 10017 110278483
Achromobacter infection 21.15 9.75 12 300787 286 110288214
Interleukin level increased 21.08 9.75 24 300775 1597 110286903
Pancreas transplant rejection 21.08 9.75 13 300786 363 110288137
Blood phosphorus increased 21.07 9.75 9 300790 16331 110272169
Urticaria pressure 21.05 9.75 8 300791 72 110288428
Autoimmune thyroiditis 21.05 9.75 51 300748 6383 110282117
Growth disorder 21.04 9.75 9 300790 113 110288387
Cholestasis 20.98 9.75 268 300531 64250 110224250
Cataract 20.92 9.75 318 300481 79167 110209333
Cytomegalovirus oesophagitis 20.88 9.75 19 300780 967 110287533
Drug tolerance 20.87 9.75 95 300704 16490 110272010
Hyperfibrinogenaemia 20.82 9.75 10 300789 167 110288333
Urethral polyp 20.77 9.75 8 300791 75 110288425
Superinfection bacterial 20.76 9.75 29 300770 2372 110286128
Anger 20.76 9.75 13 300786 18994 110269506
Head discomfort 20.74 9.75 13 300786 18987 110269513
Injection site swelling 20.64 9.75 92 300707 61698 110226802
Vasogenic cerebral oedema 20.62 9.75 28 300771 2230 110286270
COVID-19 pneumonia 20.56 9.75 172 300627 36971 110251529
Eyelid irritation 20.52 9.75 20 300779 1111 110287389
Pneumonia influenzal 20.49 9.75 37 300762 3768 110284732
Illness 20.46 9.75 135 300664 82036 110206464
Osteoporotic fracture 20.43 9.75 45 300754 5292 110283208
Pulseless electrical activity 20.41 9.75 10 300789 16747 110271753
Sinus congestion 20.41 9.75 32 300767 30427 110258073
Hypouricaemia 20.41 9.75 15 300784 563 110287937
Genital ulceration 20.37 9.75 26 300773 1949 110286551
Donor leukocyte infusion 20.32 9.75 7 300792 46 110288454
Salivary hypersecretion 20.32 9.75 11 300788 17410 110271090
Acanthosis 20.31 9.75 15 300784 567 110287933
Burkholderia cepacia complex infection 20.28 9.75 14 300785 475 110288025
Disseminated varicella zoster virus infection 20.21 9.75 21 300778 1260 110287240
Hepatic vein occlusion 20.18 9.75 12 300787 313 110288187
Blood calcium increased 20.17 9.75 12 300787 18028 110270472
Cyanosis 20.17 9.75 31 300768 29710 110258790
Vulval disorder 20.14 9.75 18 300781 895 110287605
Joint dislocation 20.11 9.75 39 300760 34151 110254349
MELAS syndrome 20.05 9.75 12 300787 317 110288183
Viral diarrhoea 20.04 9.75 15 300784 579 110287921
Ecthyma 20.03 9.75 19 300780 1020 110287480
Dyschromatopsia 20.03 9.75 21 300778 1273 110287227
Prescribed underdose 20.03 9.75 100 300699 65074 110223426
Trichosporon infection 19.95 9.75 21 300778 1279 110287221
Atypical mycobacterial pneumonia 19.95 9.75 12 300787 320 110288180
Pollakiuria 19.95 9.75 58 300741 44137 110244363
Delayed graft function 19.94 9.75 39 300760 4218 110284282
Tracheitis 19.91 9.75 24 300775 1697 110286803
Hip fracture 19.90 9.75 41 300758 35110 110253390
Neoplasm recurrence 19.90 9.75 44 300755 5188 110283312
Platelet count decreased 19.89 9.75 791 300008 229652 110058848
Phototherapy 19.87 9.75 6 300793 24 110288476
Impetigo herpetiformis 19.85 9.75 9 300790 131 110288369
Feeling cold 19.79 9.75 39 300760 33948 110254552
H1N1 influenza 19.75 9.75 32 300767 2986 110285514
Hepatic enzyme abnormal 19.74 9.75 65 300734 9698 110278802
Activated partial thromboplastin time prolonged 19.73 9.75 19 300780 22349 110266151
Embryonal rhabdomyosarcoma 19.71 9.75 7 300792 51 110288449
Respiratory symptom 19.65 9.75 8 300791 14937 110273563
Neuroendocrine carcinoma of the skin 19.64 9.75 24 300775 1721 110286779
Punctal plug insertion 19.64 9.75 4 300795 0 110288500
Gingivectomy 19.64 9.75 4 300795 0 110288500
Abscess 19.59 9.75 135 300664 27334 110261166
Macular degeneration 19.57 9.75 18 300781 21641 110266859
Megakaryocytes increased 19.54 9.75 9 300790 136 110288364
Central nervous system lymphoma 19.54 9.75 32 300767 3012 110285488
Muscle twitching 19.54 9.75 32 300767 29903 110258597
Gangrene 19.53 9.75 10 300789 16331 110272169
Adjustment disorder 19.52 9.75 3 300796 10792 110277708
Vascular graft complication 19.52 9.75 10 300789 193 110288307
Cerebrosclerosis 19.49 9.75 6 300793 26 110288474
Pustular psoriasis 19.46 9.75 81 300718 13524 110274976
Gastroenteritis clostridial 19.44 9.75 19 300780 1059 110287441
Retrograde portal vein flow 19.43 9.75 5 300794 9 110288491
Acanthamoeba infection 19.40 9.75 15 300784 608 110287892
Dystonia 19.38 9.75 25 300774 25780 110262720
Ureteric dilatation 19.36 9.75 11 300788 263 110288237
Condition aggravated 19.32 9.75 2282 298517 732554 109555946
Meningitis viral 19.31 9.75 28 300771 2371 110286129
Viral myocarditis 19.30 9.75 16 300783 718 110287782
Drug-induced liver injury 19.30 9.75 221 300578 119846 110168654
Poor quality sleep 19.29 9.75 29 300770 28048 110260452
Ocular discomfort 19.26 9.75 59 300740 8474 110280026
Pityriasis rubra pilaris 19.25 9.75 11 300788 266 110288234
Mucocutaneous leishmaniasis 19.25 9.75 14 300785 517 110287983
Oral mucosal exfoliation 19.23 9.75 23 300776 1613 110286887
Upper respiratory tract inflammation 19.22 9.75 39 300760 4332 110284168
Actinomycotic sepsis 19.20 9.75 10 300789 200 110288300
Coombs direct test positive 19.20 9.75 14 300785 519 110287981
Pneumonia pneumococcal 19.16 9.75 42 300757 4923 110283577
CSF cell count increased 19.14 9.75 9 300790 143 110288357
Hyperkeratosis 19.12 9.75 62 300737 9177 110279323
Cold sweat 19.10 9.75 19 300780 22012 110266488
Cholelithiasis 19.10 9.75 98 300701 63324 110225176
Ventricular extrasystoles 19.09 9.75 20 300779 22621 110265879
Eyelids pruritus 19.08 9.75 24 300775 1773 110286727
Genital cyst 19.03 9.75 7 300792 57 110288443
Hepatorenal syndrome 19.02 9.75 40 300759 4557 110283943
Throat irritation 18.95 9.75 78 300721 53474 110235026
Ureteral necrosis 18.95 9.75 8 300791 97 110288403
Cancer surgery 18.94 9.75 18 300781 969 110287531
Colitis erosive 18.92 9.75 11 300788 275 110288225
Gallbladder rupture 18.84 9.75 20 300779 1230 110287270
Exercise tolerance increased 18.79 9.75 6 300793 30 110288470
Type IIb hyperlipidaemia 18.79 9.75 6 300793 30 110288470
Abscess fungal 18.79 9.75 13 300786 443 110288057
Rectal cancer metastatic 18.78 9.75 14 300785 537 110287963
Gastroenteritis cryptosporidial 18.78 9.75 12 300787 357 110288143
Injection site induration 18.78 9.75 4 300795 11379 110277121
Bronchitis 18.77 9.75 307 300492 156725 110131775
Keratolysis exfoliativa acquired 18.76 9.75 5 300794 11 110288489
Acarodermatitis 18.76 9.75 25 300774 1956 110286544
Oropharyngeal pain 18.74 9.75 257 300542 135019 110153481
Blood urine present 18.72 9.75 23 300776 24222 110264278
Mycobacterium marinum infection 18.72 9.75 16 300783 749 110287751
Epstein-Barr virus antigen positive 18.66 9.75 8 300791 101 110288399
Meningoradiculitis 18.59 9.75 10 300789 214 110288286
Ear pain 18.54 9.75 78 300721 53148 110235352
Proteus infection 18.52 9.75 30 300769 2798 110285702
Erythema multiforme 18.52 9.75 18 300781 21079 110267421
Arrhythmia 18.51 9.75 112 300687 69463 110219037
Conjunctival oedema 18.50 9.75 22 300777 1534 110286966
Malignant melanoma stage I 18.49 9.75 9 300790 155 110288345
Pain of skin 18.38 9.75 105 300694 19924 110268576
Nosocomial infection 18.38 9.75 32 300767 3167 110285333
Injection site mass 18.33 9.75 24 300775 24589 110263911
Temperature regulation disorder 18.33 9.75 6 300793 12820 110275680
Dactylitis 18.32 9.75 37 300762 4096 110284404
Pericardial effusion 18.32 9.75 237 300562 56980 110231520
Endotracheal intubation 18.31 9.75 47 300752 6097 110282403
Renal infarct 18.26 9.75 33 300766 3362 110285138
Cranial nerve disorder 18.23 9.75 20 300779 1277 110287223
Hypomania 18.10 9.75 3 300796 10207 110278293
Skin injury 18.07 9.75 36 300763 3946 110284554
Therapy cessation 18.04 9.75 62 300737 44795 110243705
Blood bilirubin unconjugated increased 17.98 9.75 19 300780 1162 110287338
Proctitis 17.91 9.75 12 300787 16915 110271585
Miosis 17.89 9.75 20 300779 21963 110266537
Dermatopathic lymphadenopathy 17.88 9.75 6 300793 36 110288464
Varicocele 17.88 9.75 6 300793 36 110288464
Impaired quality of life 17.86 9.75 34 300765 29983 110258517
Cutaneous malacoplakia 17.84 9.75 9 300790 168 110288332
Tonsillitis 17.81 9.75 56 300743 8157 110280343
Conjunctival hyperaemia 17.79 9.75 45 300754 5786 110282714
Enamel anomaly 17.79 9.75 10 300789 234 110288266
Product use issue 17.78 9.75 1027 299772 310668 109977832
Hepatitis viral 17.77 9.75 21 300778 1454 110287046
Platelet count abnormal 17.65 9.75 47 300752 6235 110282265
Muscular dystrophy 17.64 9.75 10 300789 238 110288262
Prostatic specific antigen increased 17.62 9.75 6 300793 12505 110275995
Chorioretinal folds 17.48 9.75 6 300793 39 110288461
Cerebral vasoconstriction 17.48 9.75 21 300778 1480 110287020
Lung neoplasm 17.45 9.75 55 300744 8021 110280479
Metastases to bone 17.42 9.75 37 300762 31335 110257165
Nail candida 17.41 9.75 4 300795 3 110288497
Thirst 17.39 9.75 20 300779 21687 110266813
Meningococcal sepsis 17.37 9.75 9 300790 178 110288322
Magnetic resonance imaging head abnormal 17.31 9.75 33 300766 3502 110284998
Gliosis 17.28 9.75 15 300784 717 110287783
Hilar lymphadenopathy 17.28 9.75 26 300773 2276 110286224
Azoospermia 17.27 9.75 10 300789 248 110288252
Hypocomplementaemia 17.25 9.75 11 300788 326 110288174
Neutrophil morphology abnormal 17.25 9.75 8 300791 123 110288377
Concussion 17.20 9.75 5 300794 11533 110276967
Tenderness 17.20 9.75 138 300661 29299 110259201
Gamma-glutamyltransferase increased 17.20 9.75 248 300551 61061 110227439
Arteriovenous fistula aneurysm 17.19 9.75 5 300794 17 110288483
Injection site urticaria 17.17 9.75 13 300786 17202 110271298
Disseminated Bacillus Calmette-Guerin infection 17.16 9.75 11 300788 329 110288171
Eosinophilic granulomatosis with polyangiitis 17.13 9.75 4 300795 10682 110277818
Sertoli-cell-only syndrome 17.10 9.75 6 300793 42 110288458
Septic embolus 17.07 9.75 26 300773 2300 110286200
Inflammation 17.07 9.75 665 300134 192573 110095927
Joint ankylosis 17.06 9.75 27 300772 2470 110286030
Necrotising herpetic retinopathy 17.01 9.75 9 300790 186 110288314
Retching 17.01 9.75 22 300777 22660 110265840
Dysplasia 17.01 9.75 23 300776 1825 110286675
Retroperitoneal neoplasm 16.98 9.75 6 300793 43 110288457
Urinary bladder haematoma 16.97 9.75 5 300794 18 110288482
Aspiration 16.96 9.75 36 300763 30497 110258003
Sudden death 16.95 9.75 25 300774 24370 110264130
Delusion of parasitosis 16.95 9.75 10 300789 257 110288243
Laryngeal mass 16.95 9.75 7 300792 80 110288420
Rheumatic disorder 16.94 9.75 33 300766 3558 110284942
Heparin-induced thrombocytopenia 16.94 9.75 5 300794 11419 110277081
Alopecia scarring 16.93 9.75 9 300790 188 110288312
Calcification of muscle 16.93 9.75 9 300790 188 110288312
Kidney enlargement 16.92 9.75 21 300778 1530 110286970
Oedema 16.92 9.75 438 300361 209538 110078962
Neuralgia 16.91 9.75 71 300728 48407 110240093
Transfusion associated graft versus host disease 16.88 9.75 4 300795 4 110288496
Orchitis 16.87 9.75 23 300776 1839 110286661
Colectomy 16.86 9.75 37 300762 4341 110284159
CSF pressure increased 16.81 9.75 10 300789 261 110288239
Sporotrichosis 16.80 9.75 8 300791 131 110288369
Pulmonary cavitation 16.78 9.75 25 300774 2169 110286331
Blood immunoglobulin G increased 16.77 9.75 34 300765 3774 110284726
Neutropenic infection 16.77 9.75 31 300768 3214 110285286
Oesophageal candidiasis 16.76 9.75 69 300730 11465 110277035
Burkitt's lymphoma stage III 16.76 9.75 5 300794 19 110288481
Complement factor increased 16.76 9.75 5 300794 19 110288481
Muscle fatigue 16.73 9.75 35 300764 3972 110284528
Pneumoretroperitoneum 16.71 9.75 9 300790 193 110288307
Increased appetite 16.69 9.75 10 300789 14967 110273533
Acute polyneuropathy 16.66 9.75 15 300784 753 110287747
Central venous pressure increased 16.63 9.75 8 300791 134 110288366
Viral uveitis 16.63 9.75 9 300790 195 110288305
Retinal detachment 16.60 9.75 67 300732 11033 110277467
Acute promyelocytic leukaemia 16.55 9.75 23 300776 1873 110286627
Aneurysm 16.47 9.75 37 300762 4409 110284091
Polyserositis 16.40 9.75 17 300782 1017 110287483
Liver disorder 16.37 9.75 280 300519 141963 110146537
Cardiac valve vegetation 16.32 9.75 17 300782 1023 110287477
Cutaneous lymphoma 16.32 9.75 10 300789 276 110288224
Chest expansion decreased 16.31 9.75 9 300790 203 110288297
Superficial spreading melanoma stage unspecified 16.29 9.75 11 300788 360 110288140
Candida pneumonia 16.28 9.75 17 300782 1026 110287474
Lesion excision 16.27 9.75 8 300791 141 110288359
Metastases to central nervous system 16.23 9.75 23 300776 22794 110265706
Tooth dislocation 16.19 9.75 6 300793 50 110288450
Intestinal obstruction 16.17 9.75 82 300717 53145 110235355
Eye abscess 16.15 9.75 11 300788 365 110288135
Bone density decreased 16.14 9.75 12 300787 16030 110272470
Injection site bruising 16.13 9.75 78 300721 51185 110237315
CD4 lymphocytes decreased 16.12 9.75 29 300770 2945 110285555
Diabetic macroangiopathy 16.12 9.75 8 300791 144 110288356
Renal artery stenosis 16.09 9.75 33 300766 3693 110284807
Gastritis bacterial 16.08 9.75 13 300786 563 110287937
Asthenopia 16.07 9.75 30 300769 3134 110285366
Device malfunction 16.06 9.75 28 300771 25530 110262970
Clubbing 16.06 9.75 15 300784 790 110287710
Hippocampal sclerosis 16.03 9.75 9 300790 210 110288290
Autoinflammatory disease 16.02 9.75 11 300788 370 110288130
Renal cell carcinoma stage III 16.00 9.75 5 300794 23 110288477
Mass excision 16.00 9.75 11 300788 371 110288129
Non-cardiac chest pain 15.99 9.75 4 300795 10194 110278306
Polymorphonuclear chromatin clumping 15.99 9.75 4 300795 6 110288494
Cytomegalovirus test 15.99 9.75 6 300793 52 110288448
Dizziness postural 15.94 9.75 10 300789 14599 110273901
Needle issue 15.92 9.75 15 300784 17825 110270675
HCoV-OC43 infection 15.89 9.75 6 300793 53 110288447
Bone marrow myelogram abnormal 15.87 9.75 7 300792 95 110288405
Lipids increased 15.84 9.75 23 300776 1950 110286550
Hodgkin's disease 15.82 9.75 15 300784 805 110287695
Caesarean section 15.82 9.75 77 300722 13740 110274760
Bronchoalveolar lavage abnormal 15.81 9.75 11 300788 378 110288122
Antibody test negative 15.79 9.75 6 300793 54 110288446
Hypertensive cardiomyopathy 15.79 9.75 11 300788 379 110288121
Psychotic disorder 15.74 9.75 78 300721 50859 110237641
Post procedural urine leak 15.73 9.75 8 300791 152 110288348
Infected neoplasm 15.70 9.75 13 300786 582 110287918
Giant cell myocarditis 15.69 9.75 6 300793 55 110288445
Corneal perforation 15.67 9.75 16 300783 940 110287560
Infusion site extravasation 15.67 9.75 6 300793 11628 110276872
Toxic shock syndrome 15.66 9.75 20 300779 1500 110287000
Urinary bladder toxicity 15.66 9.75 5 300794 25 110288475
Galectin-3 increased 15.66 9.75 5 300794 25 110288475
Hypersomnia 15.66 9.75 33 300766 28028 110260472
Transurethral bladder resection 15.62 9.75 7 300792 99 110288401
Intentional dose omission 15.56 9.75 19 300780 20061 110268439
Complication associated with device 15.54 9.75 19 300780 20054 110268446
Parainfluenzae virus infection 15.53 9.75 48 300751 6926 110281574
Aortitis salmonella 15.50 9.75 5 300794 26 110288474
Portal vein embolism 15.49 9.75 7 300792 101 110288399
Sputum discoloured 15.48 9.75 33 300766 27912 110260588
Flatulence 15.47 9.75 81 300718 52068 110236432
Dementia 15.47 9.75 40 300759 31633 110256867
Tooth extraction 15.45 9.75 8 300791 12983 110275517
Disseminated varicella zoster vaccine virus infection 15.45 9.75 8 300791 158 110288342
Ocular pemphigoid 15.44 9.75 9 300790 226 110288274
Bifidobacterium infection 15.43 9.75 7 300792 102 110288398
Norovirus infection 15.42 9.75 25 300774 2334 110286166
Device use error 15.40 9.75 3 300796 9086 110279414
Urinary tract infection 15.32 9.75 728 300071 325554 109962946
Nerve conduction studies abnormal 15.31 9.75 8 300791 161 110288339
Renal necrosis 15.31 9.75 10 300789 309 110288191
Gingival oedema 15.31 9.75 7 300792 104 110288396
Tuberculous tenosynovitis 15.27 9.75 4 300795 8 110288492
Bladder hypertrophy 15.22 9.75 17 300782 1107 110287393
Bone tuberculosis 15.20 9.75 14 300785 724 110287776
Eye swelling 15.20 9.75 147 300652 32901 110255599
Autoimmune hepatitis 15.19 9.75 80 300719 14724 110273776
Parkinsonism 15.16 9.75 23 300776 22164 110266336
Foot fracture 15.15 9.75 29 300770 25517 110262983
Urinary tract infection pseudomonal 15.14 9.75 24 300775 2198 110286302
Vascular hyalinosis 15.14 9.75 8 300791 165 110288335
Meningoencephalitis amoebic 15.13 9.75 9 300790 235 110288265
Myasthenic syndrome 15.10 9.75 18 300781 1258 110287242
Dry skin 15.10 9.75 204 300595 107449 110181051
Disseminated cytomegaloviral infection 15.09 9.75 13 300786 615 110287885
Gingivitis ulcerative 15.07 9.75 12 300787 508 110287992
Splenectomy 15.07 9.75 15 300784 855 110287645
Acute lymphocytic leukaemia 15.06 9.75 42 300757 5723 110282777
Primary effusion lymphoma 15.06 9.75 6 300793 62 110288438
Gastrointestinal mucosal disorder 15.05 9.75 18 300781 1262 110287238
Hyperthyroidism 15.03 9.75 36 300763 29225 110259275
Molluscum contagiosum 15.02 9.75 13 300786 619 110287881
Antimitochondrial antibody positive 15.01 9.75 7 300792 109 110288391
Dysphagia 15.01 9.75 311 300488 153289 110135211
Faeces discoloured 15.00 9.75 45 300754 33903 110254597
Hydronephrosis 15.00 9.75 102 300697 20563 110267937
Herpes zoster infection neurological 14.99 9.75 12 300787 512 110287988
Lacrimation decreased 14.96 9.75 11 300788 413 110288087
Neurosyphilis 14.95 9.75 7 300792 110 110288390
Interleukin-2 receptor increased 14.95 9.75 10 300789 322 110288178
Peripheral coldness 14.95 9.75 17 300782 18523 110269977
Rhinitis allergic 14.92 9.75 16 300783 17906 110270594
Oral herpes 14.92 9.75 157 300642 35923 110252577
Ureteral neoplasm 14.90 9.75 5 300794 30 110288470
Hepatitis C virus test 14.89 9.75 6 300793 64 110288436
Herpes simplex test positive 14.88 9.75 13 300786 627 110287873
Lymphocyte morphology abnormal 14.87 9.75 16 300783 999 110287501
Parakeratosis 14.85 9.75 12 300787 519 110287981
Cutaneous symptom 14.85 9.75 15 300784 870 110287630
Lens disorder 14.84 9.75 8 300791 172 110288328
Penile squamous cell carcinoma 14.81 9.75 6 300793 65 110288435
Infection in an immunocompromised host 14.80 9.75 22 300777 1905 110286595
Blood test abnormal 14.77 9.75 35 300764 28519 110259981
Hallucination, auditory 14.77 9.75 31 300768 26366 110262134
Metapneumovirus infection 14.76 9.75 25 300774 2419 110286081
Mental status changes 14.75 9.75 134 300665 75988 110212512
Biliary sphincterotomy 14.73 9.75 3 300796 0 110288500
Choledocholithotomy 14.73 9.75 3 300796 0 110288500
Peritoneal lavage 14.73 9.75 3 300796 0 110288500
Hepatitis B e antigen 14.73 9.75 3 300796 0 110288500
Endocarditis pseudomonal 14.73 9.75 3 300796 0 110288500
Renal cell carcinoma stage II 14.73 9.75 3 300796 0 110288500
Nocardia sepsis 14.73 9.75 6 300793 66 110288434
Intravascular haemolysis 14.72 9.75 16 300783 1011 110287489
Globulins decreased 14.71 9.75 14 300785 755 110287745
Breast cancer metastatic 14.67 9.75 6 300793 11175 110277325
Human herpes virus 6 serology positive 14.66 9.75 9 300790 249 110288251
Ischaemic stroke 14.66 9.75 60 300739 41203 110247297
Tension headache 14.65 9.75 4 300795 9614 110278886
Gastroenteritis Escherichia coli 14.64 9.75 18 300781 1299 110287201
Allogenic stem cell transplantation 14.63 9.75 9 300790 250 110288250
Abdominal abscess 14.63 9.75 55 300744 8764 110279736
Lichenoid keratosis 14.62 9.75 44 300755 6258 110282242
Type 3 diabetes mellitus 14.51 9.75 7 300792 118 110288382
Lichen planus 14.49 9.75 30 300769 3380 110285120
Uveitis 14.49 9.75 105 300694 21605 110266895
Anti-platelet antibody positive 14.47 9.75 10 300789 340 110288160
Epididymitis 14.47 9.75 25 300774 2459 110286041
Palatal disorder 14.46 9.75 12 300787 539 110287961
Nasal polyps 14.45 9.75 9 300790 13191 110275309
Actinomycosis 14.39 9.75 18 300781 1322 110287178
Type III immune complex mediated reaction 14.39 9.75 16 300783 1037 110287463
Glutamate dehydrogenase level abnormal 14.38 9.75 4 300795 11 110288489
Eccrine squamous syringometaplasia 14.37 9.75 5 300794 34 110288466
Bacteroides bacteraemia 14.36 9.75 7 300792 121 110288379
Ureteritis 14.35 9.75 9 300790 259 110288241
Measles 14.35 9.75 13 300786 658 110287842
Bradypnoea 14.35 9.75 3 300796 8646 110279854
No adverse event 14.30 9.75 130 300669 73709 110214791
Acute generalised exanthematous pustulosis 14.29 9.75 23 300776 21641 110266859
Intervertebral disc protrusion 14.29 9.75 34 300765 27664 110260836
Diffuse alopecia 14.29 9.75 18 300781 1332 110287168
Oral fungal infection 14.26 9.75 35 300764 4417 110284083
Device breakage 14.25 9.75 10 300789 13759 110274741
Loss of personal independence in daily activities 14.14 9.75 520 300279 149500 110139000
Septic vasculitis 14.13 9.75 4 300795 12 110288488
Hodgkin's disease mixed cellularity stage unspecified 14.13 9.75 4 300795 12 110288488
Venous thrombosis 14.07 9.75 53 300746 8452 110280048
Quadriparesis 14.02 9.75 36 300763 4671 110283829
Apnoea 13.99 9.75 10 300789 13629 110274871
Polyomavirus test positive 13.96 9.75 9 300790 272 110288228
Mucosal ulceration 13.93 9.75 24 300775 2355 110286145
Ketoacidosis 13.93 9.75 5 300794 10082 110278418
Ventricular arrhythmia 13.93 9.75 5 300794 10082 110278418
Still's disease 13.89 9.75 4 300795 13 110288487
Central obesity 13.89 9.75 22 300777 2014 110286486
Pneumonia respiratory syncytial viral 13.88 9.75 26 300773 2723 110285777
Blood glucose abnormal 13.88 9.75 9 300790 12907 110275593
Mycobacterium abscessus infection 13.86 9.75 20 300779 1686 110286814
Anal incontinence 13.86 9.75 24 300775 21940 110266560
Hypotony of eye 13.85 9.75 11 300788 464 110288036
Ciliary body disorder 13.78 9.75 5 300794 39 110288461
Agnosia 13.76 9.75 9 300790 279 110288221
Computerised tomogram abnormal 13.75 9.75 32 300767 3904 110284596
Dialysis 13.74 9.75 96 300703 19523 110268977
Cellulitis staphylococcal 13.74 9.75 18 300781 1385 110287115
Salmonellosis 13.72 9.75 23 300776 2208 110286292
Incoherent 13.66 9.75 3 300796 8355 110280145
Vesicoureteric reflux 13.65 9.75 8 300791 203 110288297
Vaginal haemorrhage 13.57 9.75 30 300769 25044 110263456
Eating disorder 13.56 9.75 41 300758 30817 110257683
Otitis media 13.56 9.75 48 300751 7428 110281072
Hypopnoea 13.55 9.75 7 300792 11373 110277127
Pyelonephritis chronic 13.50 9.75 9 300790 288 110288212
Anal squamous cell carcinoma 13.50 9.75 14 300785 838 110287662
Acidosis hyperchloraemic 13.48 9.75 19 300780 1567 110286933
Sebaceous adenoma 13.46 9.75 5 300794 42 110288458
Coinfection 13.44 9.75 7 300792 140 110288360
Dermatitis acneiform 13.43 9.75 9 300790 12686 110275814
Skin hyperpigmentation 13.42 9.75 53 300746 8643 110279857
Tonsillar hypertrophy 13.30 9.75 21 300778 1917 110286583
Incorrect product administration duration 13.30 9.75 22 300777 20476 110268024
Gammopathy 13.28 9.75 8 300791 214 110288286
Cutaneous T-cell lymphoma stage I 13.26 9.75 7 300792 144 110288356
Electrocardiogram abnormal 13.17 9.75 19 300780 18690 110269810
Haemoglobinuria 13.16 9.75 14 300785 863 110287637
Eye infection fungal 13.15 9.75 12 300787 613 110287887
Cerebrovascular insufficiency 13.13 9.75 7 300792 147 110288353
Splenic candidiasis 13.13 9.75 6 300793 89 110288411
Back disorder 13.07 9.75 23 300776 20899 110267601
Body temperature increased 13.06 9.75 91 300708 54622 110233878
Juvenile idiopathic arthritis 13.06 9.75 41 300758 5966 110282534
Metamorphopsia 13.06 9.75 19 300780 1614 110286886
Panic attack 13.05 9.75 38 300761 28902 110259598
Photophobia 13.04 9.75 117 300682 25654 110262846
Accidental exposure to product 13.04 9.75 81 300718 49927 110238573
Haemorrhagic stroke 13.01 9.75 11 300788 13778 110274722
Apathy 12.97 9.75 15 300784 16224 110272276
Carotid artery thrombosis 12.93 9.75 5 300794 9633 110278867
Visual field defect 12.90 9.75 58 300741 10014 110278486
Squamous cell carcinoma of the cervix 12.90 9.75 9 300790 311 110288189
Perthes disease 12.87 9.75 4 300795 18 110288482
Mania 12.87 9.75 23 300776 20773 110267727
Viral vasculitis 12.86 9.75 8 300791 227 110288273
Eyelid pain 12.84 9.75 13 300786 756 110287744
Gastrointestinal oedema 12.84 9.75 28 300771 3270 110285230
Nervousness 12.84 9.75 54 300745 36797 110251703
Dengue fever 12.83 9.75 17 300782 1322 110287178
Moraxella infection 12.83 9.75 13 300786 757 110287743
Biliary tract disorder 12.83 9.75 20 300779 1806 110286694
Wrong technique in product usage process 12.81 9.75 164 300635 87184 110201316
Rhabdomyosarcoma recurrent 12.80 9.75 7 300792 155 110288345
Retinal pigment epitheliopathy 12.80 9.75 11 300788 519 110287981
Biopsy muscle abnormal 12.79 9.75 5 300794 49 110288451
Bacterial abdominal infection 12.79 9.75 5 300794 49 110288451
Toxoplasma serology positive 12.79 9.75 5 300794 49 110288451
Pre-eclampsia 12.77 9.75 52 300747 8598 110279902
Thymoma 12.75 9.75 10 300789 414 110288086
Trichodysplasia spinulosa 12.74 9.75 15 300784 1035 110287465
Lip swelling 12.73 9.75 83 300716 50584 110237916
Poor venous access 12.73 9.75 30 300769 24492 110264008
Transverse sinus thrombosis 12.72 9.75 13 300786 765 110287735
Paraspinal abscess 12.71 9.75 10 300789 416 110288084
White blood cell count increased 12.70 9.75 186 300613 96656 110191844
Focal nodular hyperplasia 12.70 9.75 14 300785 899 110287601
Echo virus infection 12.69 9.75 4 300795 19 110288481
Keratitis bacterial 12.67 9.75 8 300791 233 110288267
Mycetoma mycotic 12.67 9.75 10 300789 418 110288082
Lymphocele marsupialisation 12.66 9.75 3 300796 3 110288497
Large cell lung cancer stage IV 12.66 9.75 3 300796 3 110288497
Hyperchromasia 12.66 9.75 3 300796 3 110288497
Nail pterygium 12.66 9.75 3 300796 3 110288497
Biliary anastomosis 12.66 9.75 3 300796 3 110288497
Water pollution 12.66 9.75 3 300796 3 110288497
Leukaemic infiltration hepatic 12.66 9.75 3 300796 3 110288497
Vaginal cancer stage 0 12.66 9.75 3 300796 3 110288497
Bence Jones protein urine present 12.66 9.75 3 300796 3 110288497
Embolic stroke 12.65 9.75 4 300795 8739 110279761
Eye inflammation 12.65 9.75 54 300745 9117 110279383
Cataract operation 12.65 9.75 40 300759 5843 110282657
Rhinocerebral mucormycosis 12.64 9.75 18 300781 1499 110287001
Acute leukaemia 12.64 9.75 20 300779 1829 110286671
Gastrointestinal candidiasis 12.62 9.75 11 300788 529 110287971
Citrobacter infection 12.61 9.75 17 300782 1345 110287155
Xanthoma 12.58 9.75 8 300791 236 110288264
Graft infection 12.58 9.75 13 300786 775 110287725
Induration 12.57 9.75 23 300776 2366 110286134
Marginal zone lymphoma 12.55 9.75 8 300791 237 110288263
Cold agglutinins positive 12.52 9.75 5 300794 52 110288448
Lower motor neurone lesion 12.52 9.75 5 300794 52 110288448
Pasteurella infection 12.52 9.75 7 300792 162 110288338
Enterovirus infection 12.52 9.75 25 300774 2745 110285755
Product preparation error 12.50 9.75 7 300792 10872 110277628
Myelitis transverse 12.49 9.75 23 300776 2378 110286122
Bone pain 12.47 9.75 115 300684 65018 110223482
Refractoriness to platelet transfusion 12.46 9.75 8 300791 240 110288260
Lymphadenopathy mediastinal 12.45 9.75 38 300761 5446 110283054
Antiphospholipid antibodies positive 12.45 9.75 14 300785 919 110287581
Bile duct stent insertion 12.45 9.75 6 300793 101 110288399
Skin cancer 12.44 9.75 87 300712 17697 110270803
Retinal infiltrates 12.44 9.75 5 300794 53 110288447
Karyotype analysis abnormal 12.44 9.75 5 300794 53 110288447
Skin hypertrophy 12.44 9.75 36 300763 5011 110283489
Mydriasis 12.41 9.75 26 300773 22131 110266369
Nail dystrophy 12.41 9.75 16 300783 1212 110287288
Gastrointestinal viral infection 12.40 9.75 19 300780 1690 110286810
Appendicitis 12.38 9.75 38 300761 28426 110260074
Diffuse large B-cell lymphoma stage I 12.37 9.75 4 300795 21 110288479
Extra dose administered 12.36 9.75 9 300790 12150 110276350
Corneal scar 12.36 9.75 9 300790 333 110288167
Corneal lesion 12.34 9.75 6 300793 103 110288397
Subdural haematoma 12.34 9.75 54 300745 36400 110252100
Pseudolymphoma 12.33 9.75 16 300783 1219 110287281
Short stature 12.32 9.75 15 300784 1072 110287428
Jejunal ulcer 12.31 9.75 8 300791 245 110288255
Bradykinesia 12.31 9.75 7 300792 10781 110277719
Hairy cell leukaemia 12.29 9.75 7 300792 168 110288332
Sperm concentration decreased 12.29 9.75 6 300793 104 110288396
Photodermatosis 12.27 9.75 15 300784 1076 110287424
Flank pain 12.25 9.75 28 300771 23102 110265398
Cardiac tamponade 12.22 9.75 62 300737 11245 110277255
Skin neoplasm bleeding 12.21 9.75 4 300795 22 110288478
Anaemia 12.21 9.75 1302 299497 545784 109742716
Hepatitis C antibody positive 12.20 9.75 8 300791 249 110288251
Adjusted calcium decreased 12.20 9.75 8 300791 249 110288251
Aqueous humour leakage 12.20 9.75 3 300796 4 110288496
Respiratory tract congestion 12.18 9.75 43 300756 30814 110257686
Cytomegalovirus gastritis 12.17 9.75 12 300787 676 110287824
Cardiopulmonary failure 12.06 9.75 48 300751 7855 110280645
Hypertrophy of tongue papillae 12.04 9.75 5 300794 58 110288442
Corneal leukoma 12.04 9.75 5 300794 58 110288442
Biliary anastomosis complication 12.04 9.75 7 300792 175 110288325
Rectosigmoid cancer 12.03 9.75 9 300790 347 110288153
Refractory cytopenia with multilineage dysplasia 12.03 9.75 8 300791 255 110288245
Spindle cell sarcoma 12.00 9.75 8 300791 256 110288244
Scopulariopsis infection 12.00 9.75 7 300792 176 110288324
Norovirus test positive 12.00 9.75 14 300785 956 110287544
Hypertensive crisis 12.00 9.75 110 300689 24262 110264238
Cytomegalovirus urinary tract infection 11.99 9.75 6 300793 110 110288390
Pyelocaliectasis 11.97 9.75 15 300784 1104 110287396
Pulmonary thrombosis 11.97 9.75 12 300787 13851 110274649
Neuroendocrine tumour of the lung metastatic 11.97 9.75 7 300792 177 110288323
Vaccination site inflammation 11.96 9.75 5 300794 59 110288441
Renal adenoma 11.96 9.75 5 300794 59 110288441
Herpes simplex oesophagitis 11.96 9.75 10 300789 454 110288046
Pulse absent 11.95 9.75 8 300791 11284 110277216
Pseudallescheria infection 11.92 9.75 4 300795 24 110288476
Cerebral aspergillosis 11.91 9.75 22 300777 2280 110286220
Agranulocytosis 11.89 9.75 235 300564 61525 110226975
Chronic hepatitis 11.88 9.75 19 300780 1753 110286747
Seronegative arthritis 11.85 9.75 11 300788 13166 110275334
Pneumonia staphylococcal 11.83 9.75 40 300759 6051 110282449
Nephroblastoma 11.78 9.75 4 300795 25 110288475
Mood swings 11.77 9.75 28 300771 22784 110265716
Myeloma cast nephropathy 11.76 9.75 8 300791 265 110288235
Cerebral venous sinus thrombosis 11.76 9.75 25 300774 2870 110285630
Diffuse axonal injury 11.75 9.75 6 300793 115 110288385
Adenoviral encephalitis 11.74 9.75 5 300794 62 110288438
Multiple use of single-use product 11.73 9.75 16 300783 1280 110287220
Nasopharyngeal cancer 11.73 9.75 7 300792 184 110288316
Hepatitis B surface antigen positive 11.73 9.75 7 300792 184 110288316
Immune reconstitution inflammatory syndrome 11.72 9.75 80 300719 16146 110272354
Encephalopathy 11.68 9.75 296 300503 80759 110207741
Renal haemorrhage 11.67 9.75 23 300776 2502 110285998
Depressed level of consciousness 11.67 9.75 225 300574 112053 110176447
Acid base balance abnormal 11.65 9.75 10 300789 471 110288029
Hot flush 11.63 9.75 119 300680 65917 110222583
Myocarditis toxoplasmal 11.60 9.75 5 300794 64 110288436
Delusion 11.60 9.75 30 300769 23725 110264775
Coccidioidomycosis 11.60 9.75 18 300781 1619 110286881
Lipohypertrophy 11.59 9.75 14 300785 992 110287508
Gingival bleeding 11.59 9.75 93 300706 19746 110268754
Disseminated blastomycosis 11.58 9.75 10 300789 475 110288025
Human T-cell lymphotropic virus type I infection 11.56 9.75 6 300793 119 110288381
Eczema herpeticum 11.56 9.75 10 300789 476 110288024
Alexia 11.52 9.75 4 300795 27 110288473
Complement factor C3 decreased 11.49 9.75 9 300790 372 110288128
Initial insomnia 11.49 9.75 7 300792 10382 110278118
Coordination abnormal 11.46 9.75 33 300766 25195 110263305
Lacrimal gland neoplasm 11.45 9.75 3 300796 6 110288494
Nonkeratinising carcinoma of nasopharynx 11.45 9.75 3 300796 6 110288494
Alcaligenes infection 11.45 9.75 3 300796 6 110288494
Transfusion microchimerism 11.45 9.75 3 300796 6 110288494
Instillation site dryness 11.45 9.75 3 300796 6 110288494
Urethral adenoma 11.45 9.75 3 300796 6 110288494
Cardiopulmonary bypass 11.45 9.75 3 300796 6 110288494
Megaloblasts increased 11.45 9.75 3 300796 6 110288494
Colitis ulcerative 11.44 9.75 145 300654 77218 110211282
Calciphylaxis 11.43 9.75 31 300768 4156 110284344
Neuritis 11.42 9.75 3 300796 7396 110281104
Infective chondritis 11.40 9.75 4 300795 28 110288472
Micturition urgency 11.40 9.75 22 300777 19298 110269202
Blood thyroid stimulating hormone increased 11.38 9.75 10 300789 12291 110276209
Osteolysis 11.37 9.75 37 300762 5486 110283014
Blood iron increased 11.36 9.75 21 300778 2177 110286323
Pulmonary necrosis 11.35 9.75 11 300788 607 110287893
Skin striae 11.34 9.75 21 300778 2180 110286320
Feeling jittery 11.33 9.75 14 300785 14708 110273792
T-cell prolymphocytic leukaemia 11.33 9.75 5 300794 68 110288432
Superinfection viral 11.33 9.75 5 300794 68 110288432
Nephrosclerosis 11.33 9.75 20 300779 2001 110286499
Gastrointestinal infection 11.30 9.75 71 300728 13934 110274566
Pneumonia lipoid 11.30 9.75 7 300792 197 110288303
Secondary adrenocortical insufficiency 11.29 9.75 32 300767 4402 110284098
Nasal ulcer 11.28 9.75 23 300776 2564 110285936
Blood albumin decreased 11.28 9.75 120 300679 27532 110260968
Viral myositis 11.26 9.75 5 300794 69 110288431
Speech disorder 11.24 9.75 110 300689 61459 110227041
Nasal septum disorder 11.24 9.75 7 300792 199 110288301
Cutaneous leishmaniasis 11.20 9.75 9 300790 386 110288114
Hepatic artery thrombosis 11.18 9.75 9 300790 387 110288113
Haematoma evacuation 11.18 9.75 9 300790 387 110288113
Rectal adenocarcinoma 11.18 9.75 18 300781 1671 110286829
Pulmonary arterial hypertension 11.18 9.75 48 300751 32520 110255980
Spermatozoa progressive motility abnormal 11.16 9.75 4 300795 30 110288470
Respiratory tract infection bacterial 11.16 9.75 22 300777 2394 110286106
Parenteral nutrition 11.15 9.75 13 300786 887 110287613
Cutaneous tuberculosis 11.15 9.75 8 300791 289 110288211
Hepatic necrosis 11.15 9.75 55 300744 9867 110278633
Urethral dilatation 11.14 9.75 3 300796 7 110288493
Metastatic malignant melanoma 11.13 9.75 27 300772 3382 110285118
Eye disorder 11.12 9.75 124 300675 28782 110259718
Product prescribing issue 11.10 9.75 66 300733 12706 110275794
Anal ulcer 11.08 9.75 19 300780 1857 110286643
Systemic inflammatory response syndrome 11.08 9.75 67 300732 12976 110275524
Immune-mediated enterocolitis 11.07 9.75 7 300792 10178 110278322
Telangiectasia 11.07 9.75 19 300780 1858 110286642
Meningism 11.06 9.75 12 300787 757 110287743
Osteomyelitis 11.05 9.75 150 300649 36450 110252050
Cutaneous T-cell lymphoma stage III 11.05 9.75 4 300795 31 110288469
Alexithymia 11.05 9.75 4 300795 31 110288469
Heart rate abnormal 11.04 9.75 3 300796 7235 110281265
Activated partial thromboplastin time shortened 11.04 9.75 14 300785 1043 110287457
Infusion site pain 11.02 9.75 19 300780 17400 110271100
Roseolovirus test positive 11.01 9.75 8 300791 295 110288205
Oesophageal stenosis 11.00 9.75 35 300764 5130 110283370
Gastroenteritis salmonella 11.00 9.75 16 300783 1359 110287141
Subclavian vein thrombosis 10.98 9.75 24 300775 2808 110285692
Blindness 10.97 9.75 149 300650 36210 110252290
Extranodal marginal zone B-cell lymphoma (MALT type) 10.97 9.75 12 300787 764 110287736
Oral mucosa erosion 10.95 9.75 22 300777 2426 110286074
Erythrodermic atopic dermatitis 10.94 9.75 4 300795 32 110288468
Renal cortical necrosis 10.91 9.75 10 300789 514 110287986
Granulomatous dermatitis 10.88 9.75 10 300789 516 110287984
Pharyngeal swelling 10.87 9.75 10 300789 12022 110276478
Anaemia macrocytic 10.86 9.75 44 300755 7259 110281241
Musculoskeletal chest pain 10.85 9.75 41 300758 28806 110259694
Fracture 10.85 9.75 33 300766 24755 110263745
Cerebral venous thrombosis 10.83 9.75 26 300773 3236 110285264
Blood alkaline phosphatase increased 10.81 9.75 261 300538 70674 110217826
Nerve injury 10.80 9.75 8 300791 10705 110277795
Bronchopneumopathy 10.78 9.75 13 300786 920 110287580
CD8 lymphocytes decreased 10.77 9.75 8 300791 305 110288195
Pleuritic pain 10.77 9.75 17 300782 16123 110272377
Subacute sclerosing panencephalitis 10.77 9.75 5 300794 77 110288423
Dermatofibrosarcoma protuberans 10.77 9.75 5 300794 77 110288423
Glaucoma 10.77 9.75 101 300698 22416 110266084
Gastric mucosal lesion 10.77 9.75 15 300784 1224 110287276
Polycythaemia 10.76 9.75 26 300773 3249 110285251
Total lung capacity decreased 10.76 9.75 3 300796 7111 110281389
Pseudomembranous colitis 10.72 9.75 40 300759 6351 110282149
Hyperuricaemia 10.71 9.75 72 300727 14459 110274041
Mediastinitis 10.71 9.75 16 300783 1392 110287108
Urinary tract infection enterococcal 10.71 9.75 28 300771 3674 110284826
Acid fast bacilli infection 10.70 9.75 7 300792 217 110288283
Aeromonas infection 10.70 9.75 10 300789 527 110287973
Eyelid exfoliation 10.68 9.75 8 300791 309 110288191
Polymyositis 10.68 9.75 28 300771 3680 110284820
Clonic convulsion 10.68 9.75 17 300782 1563 110286937
Femoral artery aneurysm 10.67 9.75 7 300792 218 110288282
Corneal transplant 10.66 9.75 9 300790 414 110288086
Cardiac valve abscess 10.65 9.75 6 300793 141 110288359
Pulmonary toxicity 10.65 9.75 20 300779 17726 110270774
Chills 10.65 9.75 417 300382 190163 110098337
Hepatitis infectious mononucleosis 10.64 9.75 7 300792 219 110288281
Psychomotor skills impaired 10.63 9.75 3 300796 7055 110281445
Cardiac murmur 10.63 9.75 33 300766 24595 110263905
Fungal abscess central nervous system 10.61 9.75 7 300792 220 110288280
Hyperkinetic heart syndrome 10.61 9.75 6 300793 142 110288358
Body temperature decreased 10.60 9.75 58 300741 36877 110251623
Koebner phenomenon 10.60 9.75 5 300794 80 110288420
T-cell lymphoma recurrent 10.60 9.75 5 300794 80 110288420
Full blood count decreased 10.60 9.75 48 300751 32051 110256449
Benign neoplasm of eye 10.60 9.75 3 300796 9 110288491
Blood gonadotrophin increased 10.60 9.75 3 300796 9 110288491
Peripheral artery dissection 10.60 9.75 3 300796 9 110288491
Toothache 10.59 9.75 31 300768 23544 110264956
Carotid artery stenosis 10.59 9.75 6 300793 9257 110279243
Meningitis aseptic 10.59 9.75 54 300745 9816 110278684
Respiratory rate increased 10.55 9.75 34 300765 25049 110263451
Knee operation 10.55 9.75 3 300796 7019 110281481
Cystostomy 10.55 9.75 5 300794 81 110288419
Hospice care 10.54 9.75 11 300788 12462 110276038
Anhedonia 10.54 9.75 16 300783 15412 110273088
Cholangitis chronic 10.53 9.75 4 300795 36 110288464
Muscle rigidity 10.51 9.75 32 300767 23999 110264501
Spermatozoa progressive motility decreased 10.50 9.75 6 300793 145 110288355
Botryomycosis 10.49 9.75 5 300794 82 110288418
Dysstasia 10.49 9.75 50 300749 32936 110255564
Vulvovaginal pruritus 10.47 9.75 26 300773 3305 110285195
Anal fissure 10.46 9.75 7 300792 9874 110278626
Cell marker increased 10.45 9.75 11 300788 670 110287830
Dental plaque 10.44 9.75 5 300794 83 110288417
Anti-thyroid antibody 10.43 9.75 4 300795 37 110288463
Post procedural bile leak 10.43 9.75 9 300790 427 110288073
Lung lobectomy 10.42 9.75 7 300792 227 110288273
Escherichia pyelonephritis 10.40 9.75 13 300786 954 110287546
Renal atrophy 10.40 9.75 21 300778 2325 110286175
Head deformity 10.38 9.75 5 300794 84 110288416
Vulval cancer stage 0 10.38 9.75 5 300794 84 110288416
Injection site rash 10.38 9.75 31 300768 23388 110265112
Kidney anastomosis 10.36 9.75 3 300796 10 110288490
Vulvovaginal human papilloma virus infection 10.36 9.75 3 300796 10 110288490
Lung neoplasm malignant 10.36 9.75 52 300747 33790 110254710
Device effect incomplete 10.34 9.75 4 300795 38 110288462
Thyroglossal cyst infection 10.34 9.75 4 300795 38 110288462
Stenotrophomonas sepsis 10.31 9.75 7 300792 231 110288269
Upper-airway cough syndrome 10.30 9.75 17 300782 15840 110272660
Diverticulum intestinal 10.28 9.75 10 300789 11709 110276791
Transfusion-related acute lung injury 10.27 9.75 9 300790 436 110288064
Blastomycosis 10.25 9.75 14 300785 1121 110287379
Malignant sweat gland neoplasm 10.25 9.75 6 300793 152 110288348
Myocardial fibrosis 10.24 9.75 19 300780 1976 110286524
Onychalgia 10.23 9.75 14 300785 1123 110287377
Cardiogenic shock 10.23 9.75 103 300696 57235 110231265
Myasthenia gravis crisis 10.23 9.75 18 300781 1796 110286704
Genital discomfort 10.21 9.75 6 300793 153 110288347
Cholangitis infective 10.20 9.75 12 300787 827 110287673
Bundle branch block left 10.19 9.75 12 300787 12876 110275624
Beta 2 microglobulin increased 10.19 9.75 11 300788 690 110287810
Eructation 10.17 9.75 14 300785 14043 110274457
Bone cyst 10.16 9.75 27 300772 3576 110284924
Hiccups 10.16 9.75 12 300787 12857 110275643
Cord colitis syndrome 10.14 9.75 3 300796 11 110288489
Skin cancer metastatic 10.14 9.75 3 300796 11 110288489
Subcutaneous emphysema 10.13 9.75 22 300777 2562 110285938
Metastases to salivary gland 10.12 9.75 5 300794 89 110288411
Leukaemoid reaction 10.11 9.75 9 300790 445 110288055
Primary hypogonadism 10.10 9.75 7 300792 239 110288261
Salmonella test positive 10.07 9.75 5 300794 90 110288410
Cord blood transplant therapy 10.02 9.75 5 300794 91 110288409
Ocular hypertension 10.02 9.75 21 300778 2387 110286113
Eosinophilic pustular folliculitis 10.01 9.75 6 300793 159 110288341
Joint destruction 10 9.75 9 300790 10934 110277566
Abnormal dreams 10.00 9.75 12 300787 12768 110275732
Aortic arteriosclerosis 9.99 9.75 9 300790 10929 110277571
Severe acute respiratory syndrome 9.98 9.75 7 300792 244 110288256
CSF glucose decreased 9.97 9.75 6 300793 160 110288340
Splenic artery aneurysm 9.97 9.75 6 300793 160 110288340
Intraocular pressure increased 9.97 9.75 57 300742 10819 110277681
Jaundice 9.97 9.75 221 300578 59015 110229485
Pneumonia 9.96 9.75 2605 298194 874109 109414391
Hepatitis C RNA positive 9.95 9.75 7 300792 245 110288255
Necrotising fasciitis 9.94 9.75 44 300755 7547 110280953
Hepatitis B surface antibody 9.93 9.75 3 300796 12 110288488
Genital labial adhesions 9.93 9.75 3 300796 12 110288488
Hepatobiliary cancer 9.93 9.75 3 300796 12 110288488
Progressive bulbar palsy 9.93 9.75 5 300794 93 110288407
Cachexia 9.92 9.75 65 300734 12940 110275560
Endothelial dysfunction 9.92 9.75 8 300791 345 110288155
Palmar-plantar erythrodysaesthesia syndrome 9.91 9.75 68 300731 40957 110247543
Intestinal ulcer 9.90 9.75 21 300778 2406 110286094
N-telopeptide urine increased 9.90 9.75 4 300795 43 110288457
T-lymphocyte count abnormal 9.90 9.75 4 300795 43 110288457
Disorientation 9.88 9.75 134 300665 70537 110217963
Symptom recurrence 9.86 9.75 32 300767 4740 110283760
Premature delivery 9.86 9.75 127 300672 30505 110257995
Pulmonary fibrosis 9.85 9.75 207 300592 101835 110186665
Human anaplasmosis 9.83 9.75 5 300794 95 110288405
Segmented hyalinising vasculitis 9.83 9.75 5 300794 95 110288405
Sinonasal papilloma 9.82 9.75 4 300795 44 110288456
Hepatic atrophy 9.79 9.75 9 300790 464 110288036
Diverticulum 9.76 9.75 17 300782 15509 110272991

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AD01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Calcineurin inhibitors
ATC S01XA18 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA EPC N0000175457 Calcineurin Inhibitor Immunosuppressant
FDA MoA N0000175458 Calcineurin Inhibitors
CHEBI has role CHEBI:25212 metabolite
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35718 antifungal agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:37153 EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor
CHEBI has role CHEBI:49167 anti-asthmatic drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50903 carcinogenic agent
CHEBI has role CHEBI:149553 anticoronaviral agent
CHEBI has role CHEBI:176497 geroprotector
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D065095 Calcineurin Inhibitors
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
FDA MoA N0000185503 P-Glycoprotein Inhibitors
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35816 leprostatic drug
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:76595 nephroprotective agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

L04AD Calcineurin inhibitors 2 drugs
tacrolimusvoclosporin
S01XA Other ophthalmologicals 24 drugs
acetylcysteinealteplasealumascorbic acidavacincaptad pegolcenegermindexpanthenoldiquafosolethylmorphineguaiazulenheparininosine show all 24 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tear film insufficiency indication 46152009
Rheumatoid arthritis indication 69896004 DOID:7148
Kawasaki's disease indication 75053002 DOID:13378
Keratoconjunctivitis sicca indication 302896008 DOID:12895
Prevention of Liver Transplant Rejection indication
Prevention of Cardiac Transplant Rejection indication
Prevention of Kidney Transplant Rejection indication
Severe Recalcitrant Psoriasis indication
Graft-versus-host disease off-label use 234646005
Pure Red Cell Aplasia associated with Chronic Lymphocytic Leukemia off-label use
Prevention of Lung Transplant Rejection off-label use
Prevention of Graft Versus Host Disease off-label use
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Hyperbilirubinemia contraindication 14783006 DOID:2741
Metabolic acidosis, normal anion gap, acidifying salts contraindication 18104000
Hyperuricemia contraindication 35885006 DOID:1920
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Benign intracranial hypertension contraindication 68267002 DOID:11459
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Disorder of brain contraindication 81308009 DOID:936
Kidney disease contraindication 90708001 DOID:557
Neoplasm contraindication 108369006
Malignant lymphoma contraindication 118600007 DOID:0060058
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Toxic nephropathy contraindication 236514003
Hypertriglyceridemia contraindication 302870006
Primary malignant neoplasm contraindication 372087000
Breastfeeding (mother) contraindication 413712001
Hypertensive urgency contraindication 443482000
BK Polyomavirus Reactivation Nephropathy contraindication
Cyclosporine Toxicity contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Allergic dermatitis as manifested by excoriations (including facial and neck), miliary dermatitis, eosinophilic plaques, and self-induced alopecia Indication
Dogs Chronic keratoconjunctivitis sicca (KCS) Indication
Dogs Chronic superficial keratitis (CSK) Indication
Dogs Pruritus associated with allergic dermatitis Indication
Dogs Atopic dermatitis Indication

🐶 Veterinary products

ProductApplicantIngredients
Atopica for Cats Elanco US Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.1% VERKAZIA HARROW EYE N214965 June 23, 2021 RX EMULSION OPHTHALMIC 11612658 Jan. 27, 2026 FOR THE TREATMENT OF VERNAL KERATOCONJUNCTIVITIS IN CHILDREN AND ADULTS
0.09% CEQUA SUN PHARM N210913 Aug. 14, 2018 RX SOLUTION OPHTHALMIC 8980839 Aug. 23, 2033 INCREASE TEAR PRODUCTION IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.09% CEQUA SUN PHARM N210913 Aug. 14, 2018 RX SOLUTION OPHTHALMIC 9937225 Aug. 23, 2033 INCREASE TEAR PRODUCTION IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.1% VEVYE HARROW EYE N217469 May 30, 2023 RX SOLUTION OPHTHALMIC 12496326 Sept. 29, 2036 TREATMENT OF DRY EYE DISEASE (DED)
0.09% CEQUA SUN PHARM N210913 Aug. 14, 2018 RX SOLUTION OPHTHALMIC 11951153 Feb. 28, 2037 INCREASE TEAR PRODUCTION IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.1% VEVYE HARROW EYE N217469 May 30, 2023 RX SOLUTION OPHTHALMIC 11154513 Nov. 20, 2038 TREATMENT OF THE SIGNS AND SYMPTOMS OF DRY EYE DISEASE (DED)
0.1% VEVYE HARROW EYE N217469 May 30, 2023 RX SOLUTION OPHTHALMIC 11413323 Oct. 11, 2039 TREATMENT OF DRY EYE DISEASE (DED)
0.1% VEVYE HARROW EYE N217469 May 30, 2023 RX SOLUTION OPHTHALMIC 12059449 April 1, 2042 INCREASE TEAR PRODUCTION IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
0.1% VEVYE HARROW EYE N217469 May 30, 2023 RX SOLUTION OPHTHALMIC May 30, 2026 NEW PRODUCT
0.1% VERKAZIA HARROW EYE N214965 June 23, 2021 RX EMULSION OPHTHALMIC June 23, 2028 FOR THE TREATMENT OF VERNAL KERATOCONJUNCTIVITIS (VKC) IN CHILDREN AND ADULTS

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Peptidyl-prolyl cis-trans isomerase A Enzyme MODULATOR IC50 8.05 WOMBAT-PK CHEMBL
Multidrug resistance protein 1 Transporter EC50 6.30 WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter IC50 4.87 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP1A Enzyme IC50 7.80 WOMBAT-PK
Dihydroorotate dehydrogenase (quinone), mitochondrial Enzyme IC50 6.70 WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter IC50 5.57 CHEMBL
ATP-binding cassette sub-family G member 2 Transporter IC50 4.20 CHEMBL
Canalicular multispecific organic anion transporter 2 Transporter IC50 6.20 CHEMBL
fMet-Leu-Phe receptor GPCR ANTAGONIST EC50 6.30 IUPHAR
Bile salt export pump Transporter IC50 6.30 CHEMBL
Solute carrier organic anion transporter family member 1B1 Transporter INHIBITOR Ki 7.29 IUPHAR
Peptidyl-prolyl cis-trans isomerase FKBP4 Enzyme IC50 7.80 CHEMBL
Substance-K receptor GPCR Ki 5.86 DRUG MATRIX
Peptidyl-prolyl cis-trans isomerase B Enzyme Kd 8.01 CHEMBL
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Enzyme Kd 8.40 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP1B Enzyme Ki 8.22 CHEMBL
Peptidyl-prolyl cis-trans isomerase D Enzyme Ki 8.15 CHEMBL
Solute carrier organic anion transporter family member 1B3 Transporter INHIBITOR IC50 6.10 IUPHAR
Sodium/bile acid cotransporter Transporter INHIBITOR IC50 6 IUPHAR
Cytochrome P450 3A4 Enzyme Ki 5.31 WOMBAT-PK
Calcineurin subunit B type 1 Cytosolic other IC50 4.47 CHEMBL
Reverse transcriptase/RNaseH Enzyme IC50 6.34 CHEMBL
Bile salt export pump Transporter IC50 6.22 CHEMBL
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Kinase IC50 6.24 CHEMBL
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Enzyme IC50 4.21 CHEMBL

External reference:

IDSource
4018761 VUID
N0000147064 NUI
D00184 KEGG_DRUG
63798-73-2 SECONDARY_CAS_RN
202817 RXNORM
C0010592 UMLSCUI
CHEBI:4031 CHEBI
CHEMBL160 ChEMBL_ID
5284373 PUBCHEM_CID
DB00091 DRUGBANK_ID
3027 MMSL
31626 MMSL
4521 MMSL
72396 MMSL
d00079 MMSL
003420 NDDF
387467008 SNOMEDCT_US
80906007 SNOMEDCT_US
D016572 MESH_DESCRIPTOR_UI
1024 IUPHAR_LIGAND_ID
5086 INN_ID
4018761 VANDF
26496N541O UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Restasis MultiDose HUMAN PRESCRIPTION DRUG LABEL 1 0023-5301 EMULSION 0.50 mg OPHTHALMIC NDA 24 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 0023-9163 EMULSION 0.50 mg OPHTHALMIC NDA 24 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-0541 CAPSULE 50 mg ORAL ANDA 27 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-3108 CAPSULE 25 mg ORAL ANDA 27 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-3109 CAPSULE 100 mg ORAL ANDA 27 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-6463 CAPSULE 25 mg ORAL ANDA 27 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-6479 CAPSULE 100 mg ORAL ANDA 27 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0109 INJECTION 50 mg INTRAVENOUS NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0240 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0241 CAPSULE, LIQUID FILLED 100 mg ORAL NDA 23 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0246 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 23 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0248 CAPSULE, LIQUID FILLED 100 mg ORAL NDA 23 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0274 SOLUTION 100 mg ORAL NDA 23 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-9018 CAPSULE, LIQUID FILLED 25 mg ORAL ANDA 16 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-9019 CAPSULE, LIQUID FILLED 50 mg ORAL ANDA 16 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-9020 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 16 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 0172-7313 SOLUTION 100 mg ORAL ANDA 22 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 0378-8760 EMULSION 0.50 mg OPHTHALMIC ANDA 23 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 0480-4076 EMULSION 0.50 mg OPHTHALMIC ANDA 21 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 10702-808 EMULSION 0.50 mg OPHTHALMIC NDA authorized generic 24 sections
CYCLOSPORINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-837 CAPSULE, LIQUID FILLED 25 mg ORAL ANDA 20 sections
CYCLOSPORINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-838 CAPSULE, LIQUID FILLED 50 mg ORAL ANDA 20 sections
CYCLOSPORINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-839 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 20 sections
CYCLOSPORINE HUMAN PRESCRIPTION DRUG LABEL 1 24979-126 EMULSION 0.50 mg OPHTHALMIC ANDA 24 sections
CEQUA HUMAN PRESCRIPTION DRUG LABEL 1 47335-506 SOLUTION/ DROPS 0.00 g OPHTHALMIC NDA 22 sections
CEQUA HUMAN PRESCRIPTION DRUG LABEL 1 47335-507 SOLUTION/ DROPS 0.00 mg OPHTHALMIC NDA 22 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 50090-1242 EMULSION 0.50 mg OPHTHALMIC NDA 24 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 50090-4476 EMULSION 0.50 mg OPHTHALMIC NDA 25 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 54868-4793 EMULSION 0.50 mg OPHTHALMIC NDA 22 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 54868-5522 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 22 sections