ciclosporin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
760 59865-13-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • neoral
  • ciclosporin
  • cyclosporine
  • cyclosporin
  • ciclosporine
  • cyclosporin A
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
  • Molecular weight: 1202.64
  • Formula: C62H111N11O12
  • CLOGP: 12
  • LIPINSKI: 3
  • HAC: 23
  • HDO: 5
  • TPSA: 278.80
  • ALOGS: -5.10
  • ROTB: 15
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.25 g O
0.25 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.66 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 30 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.07 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 14, 1983 FDA NOVARTIS
Feb. 21, 2020 PMDA Novartis Pharma K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 1562.18 9.55 820 133590 17142 50453572
Eye irritation 1560.87 9.55 807 133603 16333 50454381
Transplant dysfunction 1456.93 9.55 526 133884 4158 50466556
Transplant rejection 1375.17 9.55 617 133793 8992 50461722
Graft versus host disease 943.41 9.55 415 133995 5751 50464963
Acute graft versus host disease 828.60 9.55 333 134077 3625 50467089
Product use in unapproved indication 824.77 9.55 1258 133152 114561 50356153
Chronic graft versus host disease 715.63 9.55 274 134136 2593 50468121
Ovarian cyst 682.62 9.55 439 133971 13557 50457157
Epstein-Barr virus infection 606.80 9.55 319 134091 6678 50464036
Acute graft versus host disease in skin 590.84 9.55 242 134168 2776 50467938
Acne 566.87 9.55 447 133963 19148 50451566
Graft versus host disease in skin 524.50 9.55 212 134198 2344 50468370
Graft versus host disease in gastrointestinal tract 500.51 9.55 210 134200 2571 50468143
Blood iron abnormal 483.47 9.55 216 134194 3110 50467604
Kidney transplant rejection 467.30 9.55 223 134187 3764 50466950
Post transplant lymphoproliferative disorder 462.06 9.55 225 134185 3979 50466735
Foreign body sensation in eyes 416.16 9.55 163 134247 1648 50469066
Posterior reversible encephalopathy syndrome 402.89 9.55 327 134083 14601 50456113
Eye pain 373.00 9.55 418 133992 28031 50442683
Acute graft versus host disease in intestine 371.28 9.55 146 134264 1493 50469221
Renal impairment 369.23 9.55 695 133715 74966 50395748
Adenovirus infection 367.65 9.55 176 134234 2992 50467722
Thrombotic microangiopathy 359.16 9.55 247 134163 8544 50462170
Blood parathyroid hormone decreased 339.08 9.55 220 134190 6894 50463820
Completed suicide 328.86 9.55 4 134406 131885 50338829
Ocular hyperaemia 327.60 9.55 333 134077 19959 50450755
Panniculitis 324.21 9.55 229 134181 8274 50462440
Haemophagocytic lymphohistiocytosis 318.78 9.55 228 134182 8405 50462309
Granuloma skin 309.87 9.55 193 134217 5625 50465089
Blood creatinine increased 309.44 9.55 648 133762 75512 50395202
Cystitis haemorrhagic 304.63 9.55 163 134247 3539 50467175
Pemphigus 302.54 9.55 3 134407 120163 50350551
Nephropathy toxic 287.20 9.55 208 134202 7821 50462893
BK virus infection 283.41 9.55 143 134267 2738 50467976
Skin necrosis 270.17 9.55 227 134183 10640 50460074
Multiple organ dysfunction syndrome 268.96 9.55 481 133929 49856 50420858
Immunosuppressant drug level increased 254.44 9.55 136 134274 2946 50467768
Glossodynia 253.18 9.55 13 134397 115556 50355158
Cytomegalovirus viraemia 245.22 9.55 154 134256 4555 50466159
Basal cell carcinoma 233.50 9.55 299 134111 23057 50447657
Fatigue 226.66 9.55 1040 133370 706561 49764153
Hand deformity 220.33 9.55 11 134399 100188 50370526
Product container issue 217.77 9.55 96 134314 1336 50469378
Instillation site pain 207.33 9.55 80 134330 774 50469940
Rheumatoid nodule 203.74 9.55 208 134202 12527 50458187
Fall 198.68 9.55 367 134043 334565 50136149
Aspergillus infection 193.76 9.55 154 134256 6667 50464047
Systemic lupus erythematosus 191.73 9.55 67 134343 140555 50330159
Bronchopulmonary aspergillosis 189.57 9.55 159 134251 7433 50463281
Acute graft versus host disease in liver 187.75 9.55 68 134342 542 50470172
Cytomegalovirus infection reactivation 181.15 9.55 103 134307 2528 50468186
Nausea 181.02 9.55 1117 133293 704281 49766433
Ulcer 180.88 9.55 245 134165 19955 50450759
Scleral hyperaemia 180.48 9.55 54 134356 214 50470500
Swelling 174.22 9.55 166 134244 200706 50270008
Epstein-Barr virus associated lymphoproliferative disorder 169.55 9.55 85 134325 1604 50469110
Chronic graft versus host disease in skin 169.36 9.55 65 134345 619 50470095
Hypercalcaemia 169.08 9.55 256 134154 23096 50447618
Eye pruritus 165.66 9.55 185 134225 12349 50458365
Drug ineffective 163.86 9.55 3065 131345 816268 49654446
Wound 163.23 9.55 40 134370 105754 50364960
Cytomegalovirus test positive 161.25 9.55 95 134315 2497 50468217
Demyelination 160.45 9.55 131 134279 5895 50464819
Therapeutic response decreased 158.04 9.55 372 134038 46859 50423855
Complications of transplanted kidney 157.54 9.55 88 134322 2085 50468629
Abdominal discomfort 153.65 9.55 236 134174 231405 50239309
Liver transplant rejection 152.68 9.55 73 134337 1237 50469477
Graft versus host disease in liver 151.79 9.55 55 134355 439 50470275
Anti-cyclic citrullinated peptide antibody positive 151.27 9.55 9 134401 70578 50400136
Death 149.27 9.55 410 134000 324969 50145745
Dizziness 149.01 9.55 450 133960 345919 50124795
Eye discharge 148.38 9.55 117 134293 5006 50465708
Pseudomonas infection 147.18 9.55 152 134258 9278 50461436
SLE arthritis 145.80 9.55 57 134353 573 50470141
Red blood cell sedimentation rate increased 145.57 9.55 272 134138 29144 50441570
Skin ulcer 143.90 9.55 301 134109 35017 50435697
Liver function test abnormal 143.78 9.55 345 134065 43994 50426720
Drug eruption 142.29 9.55 238 134172 23368 50447346
Intentional overdose 140.19 9.55 6 134404 62498 50408216
Obliterative bronchiolitis 139.70 9.55 77 134333 1776 50468938
Lacrimation increased 138.52 9.55 197 134213 16795 50453919
Pericarditis 137.60 9.55 22 134388 78667 50392047
Dyspnoea 137.11 9.55 873 133537 546735 49923979
Constipation 134.20 9.55 178 134232 185530 50285184
Gingival hypertrophy 134.00 9.55 68 134342 1318 50469396
Hypotension 133.35 9.55 265 134145 235204 50235510
Complications of bone marrow transplant 132.50 9.55 49 134361 417 50470297
Smooth muscle cell neoplasm 131.34 9.55 56 134354 715 50469999
Epstein-Barr viraemia 130.87 9.55 58 134352 818 50469896
Pain 129.52 9.55 954 133456 577949 49892765
Inflammation 129.12 9.55 388 134022 56524 50414190
Chronic allograft nephropathy 125.43 9.55 52 134358 616 50470098
Human herpesvirus 6 infection 122.73 9.55 80 134330 2526 50468188
Viraemia 122.54 9.55 59 134351 1016 50469698
Psoriasis 121.93 9.55 432 133978 68568 50402146
Venoocclusive disease 119.29 9.55 70 134340 1826 50468888
C-reactive protein increased 119.02 9.55 418 133992 66056 50404658
Drug abuse 118.66 9.55 11 134399 59835 50410879
Lung transplant rejection 118.38 9.55 52 134358 717 50469997
Heart transplant rejection 111.90 9.55 43 134367 411 50470303
Elbow deformity 111.16 9.55 60 134350 1326 50469388
Drug intolerance 110.16 9.55 974 133436 218130 50252584
Discomfort 109.49 9.55 77 134333 108303 50362411
Chronic graft versus host disease in liver 108.57 9.55 37 134373 241 50470473
Vomiting 108.40 9.55 748 133662 460010 50010704
Treatment failure 107.97 9.55 680 133730 136957 50333757
Venoocclusive liver disease 107.95 9.55 90 134320 4171 50466543
Duodenal ulcer perforation 107.10 9.55 3 134407 45608 50425106
Pneumonia cytomegaloviral 104.90 9.55 65 134345 1876 50468838
Transplant failure 103.80 9.55 58 134352 1375 50469339
Asthenia 103.28 9.55 466 133944 318576 50152138
Cytomegalovirus colitis 102.80 9.55 64 134346 1863 50468851
Immunosuppressant drug level decreased 102.71 9.55 49 134361 826 50469888
Impaired gastric emptying 102.27 9.55 121 134289 8597 50462117
Weight increased 102.01 9.55 242 134168 201649 50269065
Enthesopathy 101.69 9.55 110 134300 7083 50463631
Anxiety 101.25 9.55 199 134211 177407 50293307
Lymphocele 101.12 9.55 47 134363 745 50469969
Alveolar proteinosis 99.72 9.55 36 134374 284 50470430
Helicobacter infection 98.90 9.55 9 134401 49693 50421021
Red blood cell sedimentation rate 97.67 9.55 79 134331 3507 50467207
Aspartate aminotransferase increased 96.54 9.55 437 133973 77561 50393153
Confusional state 94.62 9.55 222 134188 185706 50285008
Hypogammaglobulinaemia 92.82 9.55 94 134316 5605 50465109
Mucormycosis 92.63 9.55 66 134344 2417 50468297
Soft tissue disorder 92.51 9.55 82 134328 4132 50466582
Electrocardiogram QT prolonged 91.85 9.55 14 134396 51872 50418842
Vision blurred 90.97 9.55 432 133978 78215 50392499
Aplastic anaemia 90.51 9.55 107 134303 7596 50463118
Lymphoproliferative disorder 90.49 9.55 69 134341 2808 50467906
Ankylosing spondylitis 89.99 9.55 103 134307 7062 50463652
Skin plaque 89.86 9.55 97 134313 6231 50464483
Oral administration complication 89.41 9.55 26 134384 91 50470623
Dehydration 88.45 9.55 169 134241 152280 50318434
Syncope 88.19 9.55 86 134324 102916 50367798
Erythema of eyelid 88.11 9.55 57 134353 1776 50468938
Somnolence 87.17 9.55 175 134235 154810 50315904
Gastrooesophageal reflux disease 85.87 9.55 48 134362 76380 50394334
Alanine aminotransferase increased 85.80 9.55 462 133948 87897 50382817
Cutaneous T-cell lymphoma 85.72 9.55 49 134361 1215 50469499
Proteinuria 82.76 9.55 154 134256 16443 50454271
Tenosynovitis 82.47 9.55 120 134290 10445 50460269
Hirsutism 82.06 9.55 44 134366 959 50469755
Hepatosplenic T-cell lymphoma 81.68 9.55 37 134373 551 50470163
Psoriatic arthropathy 80.96 9.55 292 134118 46740 50423974
Leukaemia recurrent 80.75 9.55 47 134363 1207 50469507
Renal transplant failure 80.20 9.55 37 134373 576 50470138
Cerebrovascular accident 79.96 9.55 80 134330 94600 50376114
Chorioretinopathy 78.33 9.55 40 134370 786 50469928
Polyomavirus viraemia 76.59 9.55 33 134377 433 50470281
Irritable bowel syndrome 76.35 9.55 21 134389 51420 50419294
Back pain 75.62 9.55 314 134096 219716 50250998
Arthropathy 74.49 9.55 196 134214 157710 50313004
Sepsis 73.07 9.55 603 133807 132322 50338392
Focal segmental glomerulosclerosis 72.71 9.55 45 134365 1296 50469418
Epstein-Barr virus infection reactivation 72.39 9.55 33 134377 499 50470215
Off label use 72.00 9.55 1707 132703 472719 49997995
Diabetes mellitus 71.69 9.55 289 134121 48744 50421970
Tongue disorder 70.95 9.55 104 134306 9112 50461602
Graft complication 70.63 9.55 25 134385 185 50470529
Nocardiosis 70.03 9.55 48 134362 1650 50469064
Leukopenia 69.60 9.55 359 134051 67169 50403545
Herpes zoster 69.31 9.55 371 134039 70415 50400299
Abdominal pain upper 69.03 9.55 206 134204 159103 50311611
Nasopharyngitis 69.01 9.55 271 134139 192656 50278058
Diffuse large B-cell lymphoma 68.77 9.55 80 134330 5582 50465132
Loss of personal independence in daily activities 68.49 9.55 367 134043 69683 50401031
Pathogen resistance 68.46 9.55 80 134330 5609 50465105
Hypertrichosis 68.12 9.55 39 134371 970 50469744
Encephalitis viral 67.90 9.55 46 134364 1551 50469163
Malaise 67.73 9.55 568 133842 334964 50135750
Graft versus host disease in lung 67.67 9.55 28 134382 330 50470384
Diarrhoea 66.17 9.55 1133 133277 587343 49883371
Depression 66.00 9.55 222 134188 165201 50305513
Drug tolerance decreased 65.70 9.55 100 134310 9060 50461654
Hair follicle tumour benign 65.56 9.55 28 134382 359 50470355
C-reactive protein abnormal 65.33 9.55 192 134218 27617 50443097
Suicide attempt 64.91 9.55 28 134382 51704 50419010
Disease recurrence 64.80 9.55 156 134254 19925 50450789
Glomerulosclerosis 64.59 9.55 27 134383 327 50470387
Contusion 64.49 9.55 125 134285 112058 50358656
Rheumatoid factor positive 64.14 9.55 26 134384 49833 50420881
Viral haemorrhagic cystitis 64.10 9.55 33 134377 660 50470054
Stem cell transplant 63.76 9.55 45 134365 1623 50469091
Hyponatraemia 63.59 9.55 98 134312 96041 50374673
Hyperhidrosis 63.23 9.55 87 134323 89339 50381375
Lower respiratory tract infection 63.01 9.55 97 134313 95104 50375610
Muscle spasms 62.96 9.55 151 134259 125402 50345312
Superficial injury of eye 62.72 9.55 22 134388 158 50470556
Scedosporium infection 62.60 9.55 28 134382 404 50470310
Fear of injection 62.35 9.55 79 134331 6024 50464690
Aplasia pure red cell 62.30 9.55 66 134344 4149 50466565
Folliculitis 62.12 9.55 14 134396 39211 50431503
Hypokalaemia 61.82 9.55 86 134324 87906 50382808
Malignant neoplasm progression 61.71 9.55 54 134356 68070 50402644
Cardio-respiratory arrest 60.31 9.55 34 134376 53858 50416856
Palpitations 59.99 9.55 99 134311 94407 50376307
Blood lactate dehydrogenase increased 59.97 9.55 149 134261 19413 50451301
Squamous cell carcinoma 59.10 9.55 87 134323 7652 50463062
Cardiac failure congestive 58.75 9.55 83 134327 84299 50386415
Pneumocystis jirovecii pneumonia 58.58 9.55 124 134286 14539 50456175
Bradycardia 58.44 9.55 51 134359 64375 50406339
Pneumomediastinum 58.26 9.55 37 134373 1116 50469598
Klebsiella infection 58.03 9.55 83 134327 7111 50463603
Epstein-Barr virus associated lymphoma 57.30 9.55 27 134383 442 50470272
Chronic graft versus host disease in eye 57.29 9.55 18 134392 87 50470627
Blood bilirubin increased 56.91 9.55 201 134209 31837 50438877
Multiple sclerosis relapse 55.93 9.55 22 134388 42942 50427772
Varicella zoster virus infection 55.77 9.55 49 134361 2440 50468274
Headache 55.66 9.55 979 133431 505556 49965158
Device expulsion 55.29 9.55 6 134404 28816 50441898
Toxicity to various agents 54.33 9.55 336 134074 212163 50258551
Herpes simplex 53.95 9.55 80 134330 7082 50463632
Flushing 52.80 9.55 60 134350 66955 50403759
Therapeutic product effect variable 52.65 9.55 34 134376 1056 50469658
Chronic obstructive pulmonary disease 52.59 9.55 39 134371 53396 50417318
Rash pruritic 52.55 9.55 259 134151 47587 50423127
Rheumatoid arthritis 52.52 9.55 792 133618 201758 50268956
Decreased appetite 52.25 9.55 316 134094 200607 50270107
Injection site pain 52.19 9.55 138 134272 110886 50359828
Injection site erythema 51.88 9.55 74 134336 74862 50395852
Hypoglycaemia 51.59 9.55 40 134370 53541 50417173
Drug resistance 51.37 9.55 138 134272 18851 50451863
Impaired healing 51.26 9.55 66 134344 69720 50400994
Chronic graft versus host disease oral 51.20 9.55 17 134393 101 50470613
Pyrexia 51.03 9.55 1346 133064 378857 50091857
Alanine aminotransferase abnormal 50.94 9.55 59 134351 4097 50466617
Knee arthroplasty 50.70 9.55 16 134394 35830 50434884
Nephrectomy 50.36 9.55 30 134380 805 50469909
Eyelid oedema 49.93 9.55 90 134320 9376 50461338
Eyelid irritation 49.86 9.55 23 134387 358 50470356
Blood glucose increased 49.80 9.55 70 134340 71254 50399460
Kidney fibrosis 49.74 9.55 38 134372 1551 50469163
Balance disorder 49.57 9.55 69 134341 70521 50400193
Hepatic enzyme increased 49.08 9.55 193 134217 137187 50333527
Leukoencephalopathy 49.07 9.55 56 134354 3827 50466887
Kaposi's sarcoma 49.00 9.55 18 134392 150 50470564
Red blood cell schistocytes present 48.85 9.55 20 134390 229 50470485
Lactic acidosis 48.78 9.55 14 134396 33341 50437373
International normalised ratio increased 48.61 9.55 27 134383 43125 50427589
Arthralgia 47.80 9.55 849 133561 437853 50032861
Cognitive disorder 47.72 9.55 29 134381 44094 50426620
Laryngitis fungal 47.54 9.55 17 134393 130 50470584
Product delivery mechanism issue 47.33 9.55 21 134389 297 50470417
Loss of consciousness 47.33 9.55 132 134278 104221 50366493
Pneumonia viral 46.76 9.55 73 134337 6761 50463953
Abnormal sensation in eye 46.66 9.55 37 134373 1596 50469118
Hypoaesthesia 46.60 9.55 177 134233 127080 50343634
Pancytopenia 46.57 9.55 382 134028 83648 50387066
Insomnia 46.52 9.55 273 134137 174592 50296122
Bone marrow failure 46.25 9.55 170 134240 27454 50443260
Renal tubular atrophy 46.21 9.55 25 134385 555 50470159
Skin lesion 45.19 9.55 165 134245 26562 50444152
Acute myeloid leukaemia recurrent 45.18 9.55 34 134376 1356 50469358
Erythema 44.97 9.55 590 133820 145824 50324890
Hepatic function abnormal 44.90 9.55 189 134221 32492 50438222
Fusarium infection 44.64 9.55 24 134386 526 50470188
Nephrotic syndrome 44.44 9.55 59 134351 4711 50466003
Bronchiolitis obliterans syndrome 44.24 9.55 15 134395 96 50470618
Disseminated intravascular coagulation 43.83 9.55 122 134288 17013 50453701
Therapy non-responder 43.05 9.55 257 134153 50765 50419949
Haemolytic uraemic syndrome 42.88 9.55 41 134369 2278 50468436
Cytomegalovirus chorioretinitis 42.75 9.55 34 134376 1473 50469241
Cardiac arrest 42.41 9.55 100 134310 83551 50387163
Sinusitis 42.38 9.55 272 134138 170286 50300428
Normal newborn 42.38 9.55 69 134341 6622 50464092
Paraesthesia 42.26 9.55 170 134240 120073 50350641
Nephroureterectomy 41.82 9.55 9 134401 3 50470711
Lupus vasculitis 41.64 9.55 22 134388 465 50470249
Hospitalisation 41.43 9.55 73 134337 67864 50402850
Microangiopathy 41.32 9.55 27 134383 856 50469858
Overlap syndrome 41.17 9.55 24 134386 618 50470096
Toxic leukoencephalopathy 41.14 9.55 24 134386 619 50470095
Bone marrow transplant 40.76 9.55 24 134386 630 50470084
Neurotoxicity 40.76 9.55 108 134302 14632 50456082
Staphylococcal infection 40.69 9.55 195 134215 35421 50435293
Bacterial sepsis 40.51 9.55 49 134361 3563 50467151
Serum ferritin increased 40.47 9.55 59 134351 5143 50465571
Instillation site reaction 40.43 9.55 21 134389 428 50470286
Clear cell renal cell carcinoma 40.38 9.55 30 134380 1173 50469541
Toxoplasmosis 40.26 9.55 32 134378 1385 50469329
Septic shock 40.22 9.55 275 134135 56900 50413814
Device dislocation 40.05 9.55 5 134405 21541 50449173
Ocular discomfort 39.87 9.55 47 134363 3326 50467388
Cystitis viral 39.86 9.55 14 134396 101 50470613
Disseminated tuberculosis 39.66 9.55 41 134369 2505 50468209
Sedation 39.31 9.55 16 134394 30594 50440120
JC virus infection 39.21 9.55 35 134375 1780 50468934
Visual acuity reduced 38.96 9.55 130 134280 20009 50450705
Dyspepsia 38.83 9.55 87 134323 74010 50396704
Osteonecrosis of jaw 38.63 9.55 19 134391 32507 50438207
Acute lymphocytic leukaemia recurrent 38.59 9.55 36 134374 1939 50468775
Orthostatic hypotension 38.53 9.55 15 134395 29466 50441248
Sopor 38.49 9.55 4 134406 19875 50450839
Systemic candida 38.28 9.55 42 134368 2748 50467966
Cough 38.24 9.55 433 133977 240831 50229883
Enterococcal infection 38.20 9.55 67 134343 6831 50463883
Escherichia urinary tract infection 38.20 9.55 85 134325 10310 50460404
Pneumonia fungal 38.06 9.55 52 134358 4268 50466446
Drug level increased 37.83 9.55 125 134285 19143 50451571
Ill-defined disorder 37.80 9.55 54 134356 54600 50416114
Agitation 37.66 9.55 52 134358 53332 50417382
Complications of transplanted lung 37.20 9.55 16 134394 209 50470505
Oedema peripheral 37.19 9.55 256 134154 157705 50313009
Pulmonary haemorrhage 37.19 9.55 64 134346 6428 50464286
Bacteraemia 37.15 9.55 103 134307 14330 50456384
Atrial fibrillation 36.93 9.55 142 134268 101603 50369111
Adrenal suppression 36.79 9.55 25 134385 847 50469867
Engraft failure 36.27 9.55 18 134392 332 50470382
Human polyomavirus infection 36.15 9.55 17 134393 277 50470437
Tendonitis 36.09 9.55 112 134298 16593 50454121
Graft loss 35.93 9.55 18 134392 339 50470375
Lung infiltration 35.89 9.55 97 134313 13296 50457418
Epicondylitis 35.77 9.55 34 134376 1875 50468839
Polyomavirus-associated nephropathy 35.67 9.55 31 134379 1521 50469193
Glomerulonephritis 35.55 9.55 31 134379 1528 50469186
Blood stem cell transplant failure 35.52 9.55 14 134396 144 50470570
Type 2 diabetes mellitus 35.25 9.55 24 134386 34351 50436363
Hypoproteinaemia 35.06 9.55 33 134377 1798 50468916
Renal tubular necrosis 34.99 9.55 81 134329 10087 50460627
Wheezing 34.90 9.55 70 134340 61977 50408737
Intentional product misuse 34.52 9.55 44 134366 46690 50424024
Graft versus host disease in eye 34.38 9.55 11 134399 57 50470657
Fungaemia 34.26 9.55 34 134376 1978 50468736
Drug withdrawal syndrome 34.06 9.55 12 134398 25069 50445645
Rash 33.86 9.55 894 133516 436577 50034137
Feeling abnormal 33.85 9.55 195 134215 125297 50345417
Idiopathic pneumonia syndrome 33.80 9.55 17 134393 323 50470391
Viral test positive 33.76 9.55 14 134396 166 50470548
Eye swelling 33.75 9.55 124 134286 20020 50450694
Oxygen saturation decreased 33.69 9.55 92 134318 73156 50397558
Tuberculosis gastrointestinal 33.61 9.55 17 134393 327 50470387
Clubbing 33.47 9.55 16 134394 271 50470443
Suicidal ideation 33.33 9.55 60 134350 55325 50415389
Splenomegaly 33.29 9.55 77 134333 9583 50461131
Lymphadenectomy 33.18 9.55 24 134386 900 50469814
Cytomegalovirus enterocolitis 33.17 9.55 20 134390 549 50470165
Paroxysmal nocturnal haemoglobinuria 33.13 9.55 13 134397 132 50470582
Lymphocele marsupialisation 33.01 9.55 8 134402 10 50470704
Pneumatosis intestinalis 33.00 9.55 34 134376 2069 50468645
Muscle fatigue 32.99 9.55 35 134375 2204 50468510
Sleep disorder due to general medical condition, insomnia type 32.95 9.55 168 134242 31279 50439435
Hepatitis C 32.91 9.55 52 134358 4865 50465849
Serum sickness 32.82 9.55 37 134373 2495 50468219
Chest pain 32.71 9.55 306 134104 176576 50294138
Asthenopia 32.63 9.55 33 134377 1964 50468750
Myocardial infarction 32.47 9.55 124 134286 88903 50381811
Mucosal inflammation 32.46 9.55 200 134210 39942 50430772
Multiple use of single-use product 32.27 9.55 25 134385 1042 50469672
Fluid retention 32.18 9.55 53 134357 50596 50420118
Mechanical ventilation 32.03 9.55 26 134384 1160 50469554
Dysplasia 32.02 9.55 21 134389 670 50470044
Chest discomfort 32.00 9.55 132 134278 92590 50378124
Chronic graft versus host disease in intestine 31.97 9.55 11 134399 74 50470640
Renal mass 31.90 9.55 32 134378 1886 50468828
Acinetobacter infection 31.79 9.55 28 134382 1399 50469315
Eyelids pruritus 31.75 9.55 22 134388 770 50469944
Opportunistic infection 31.66 9.55 30 134380 1648 50469066
Systemic mycosis 31.65 9.55 25 134385 1072 50469642
Disseminated cryptococcosis 31.60 9.55 17 134393 373 50470341
Gouty tophus 31.58 9.55 13 134397 151 50470563
Product dose omission issue 31.50 9.55 324 134086 183514 50287200
Intentional self-injury 31.48 9.55 11 134399 23101 50447613
Maternal exposure during pregnancy 31.47 9.55 272 134138 159506 50311208
Blood urea increased 31.32 9.55 135 134275 23450 50447264
Injury 31.27 9.55 51 134359 48874 50421840
Femur fracture 31.22 9.55 32 134378 37432 50433282
Pulmonary tuberculosis 31.14 9.55 47 134363 4226 50466488
Pain in extremity 30.95 9.55 524 133886 272341 50198373
Asthma 30.95 9.55 127 134283 89210 50381504
Gastroenteritis rotavirus 30.93 9.55 12 134398 118 50470596
Condition aggravated 30.87 9.55 1019 133391 296039 50174675
Gastroenteritis clostridial 30.83 9.55 19 134391 543 50470171
Drug ineffective for unapproved indication 30.75 9.55 125 134285 21156 50449558
Unresponsive to stimuli 30.56 9.55 22 134388 30587 50440127
Eyelid exfoliation 30.40 9.55 12 134398 124 50470590
Bone marrow transplant rejection 30.32 9.55 10 134400 58 50470656
Delirium 30.29 9.55 34 134376 38158 50432556
Life support 30.06 9.55 14 134396 223 50470491
Memory impairment 29.94 9.55 109 134301 79251 50391463
Therapeutic product effect incomplete 29.86 9.55 373 134037 91142 50379572
Transient ischaemic attack 29.81 9.55 25 134385 32185 50438529
Cerebral toxoplasmosis 29.40 9.55 20 134390 679 50470035
Laryngeal disorder 29.31 9.55 22 134388 874 50469840
Ovarian failure 29.26 9.55 24 134386 1087 50469627
Cardiac disorder 29.19 9.55 43 134367 42936 50427778
Blood potassium decreased 29.18 9.55 33 134377 36912 50433802
General physical health deterioration 29.16 9.55 240 134170 142194 50328520
Autoimmune haemolytic anaemia 29.16 9.55 44 134366 3955 50466759
Oral lichen planus 29.03 9.55 18 134392 520 50470194
Acute respiratory distress syndrome 28.97 9.55 122 134288 20977 50449737
Jaw fracture 28.77 9.55 34 134376 2412 50468302
Instillation site irritation 28.73 9.55 11 134399 104 50470610
T-cell lymphoma 28.73 9.55 19 134391 615 50470099
Haemolytic anaemia 28.71 9.55 71 134339 9221 50461493
Renal tubular injury 28.64 9.55 16 134394 379 50470335
Skin mass 28.60 9.55 50 134360 5085 50465629
Respiratory tract infection bacterial 28.49 9.55 13 134397 197 50470517
Drug tolerance 28.43 9.55 49 134361 4927 50465787
Lymphadenopathy 28.42 9.55 169 134241 33330 50437384
Pneumocystis jirovecii infection 28.37 9.55 25 134385 1250 50469464
Enterococcal sepsis 28.37 9.55 25 134385 1250 50469464
Hiatus hernia 28.15 9.55 7 134403 18337 50452377
Complications of transplant surgery 28.09 9.55 12 134398 154 50470560
Influenza like illness 28.08 9.55 70 134340 57389 50413325
Renal arteriosclerosis 28.07 9.55 9 134401 47 50470667
Acute myocardial infarction 27.99 9.55 22 134388 29251 50441463
Eye infection toxoplasmal 27.84 9.55 14 134396 266 50470448
Joint swelling 27.82 9.55 471 133939 244815 50225899
Herpes virus infection 27.80 9.55 48 134362 4833 50465881
Growth retardation 27.79 9.55 23 134387 1055 50469659
Neoplasm progression 27.77 9.55 22 134388 29135 50441579
Bursitis 27.73 9.55 12 134398 22123 50448591
Medication error 27.71 9.55 33 134377 36071 50434643
Deep vein thrombosis 27.44 9.55 101 134309 73203 50397511
Pulmonary nocardiosis 27.41 9.55 12 134398 164 50470550
Blast crisis in myelogenous leukaemia 27.30 9.55 17 134393 495 50470219
Cytomegalovirus syndrome 27.26 9.55 10 134400 83 50470631
Haemodialysis 27.02 9.55 65 134345 8297 50462417
Haematuria 26.95 9.55 137 134273 25476 50445238
Thrombotic thrombocytopenic purpura 26.94 9.55 40 134370 3545 50467169
Bone pain 26.80 9.55 53 134357 47176 50423538
Psoriasis area severity index increased 26.76 9.55 9 134401 56 50470658
Ulcerative keratitis 26.74 9.55 32 134378 2301 50468413
Concomitant disease progression 26.70 9.55 30 134380 2015 50468699
Lupus nephritis 26.49 9.55 32 134378 2323 50468391
Glomerulonephritis membranous 26.38 9.55 17 134393 526 50470188
Pulmonary embolism 26.38 9.55 160 134250 101544 50369170
Eye infection fungal 26.36 9.55 10 134400 92 50470622
Drug level fluctuating 26.24 9.55 15 134395 372 50470342
Steroid diabetes 26.22 9.55 21 134389 919 50469795
Eye inflammation 26.12 9.55 43 134367 4165 50466549
Renal lymphocele 26.10 9.55 9 134401 61 50470653
Sinus tachycardia 26.09 9.55 12 134398 21342 50449372
Dilatation intrahepatic duct acquired 26.05 9.55 18 134392 627 50470087
Arthritis 26.00 9.55 348 134062 86373 50384341
Full blood count abnormal 25.81 9.55 15 134395 23373 50447341
Haptoglobin decreased 25.80 9.55 18 134392 637 50470077
Scleroderma 25.77 9.55 46 134364 4755 50465959
Respiratory arrest 25.73 9.55 25 134385 29984 50440730
Inappropriate schedule of product administration 25.72 9.55 298 134112 71533 50399181
Product storage error 25.53 9.55 81 134329 12143 50458571
Cutaneous T-cell lymphoma stage IV 25.46 9.55 6 134404 6 50470708
Laryngitis viral 25.40 9.55 7 134403 19 50470695
Granuloma 25.38 9.55 46 134364 4812 50465902
Renal failure 25.32 9.55 411 133999 106222 50364492
Bacillary angiomatosis 25.26 9.55 9 134401 68 50470646
Photophobia 25.24 9.55 92 134318 14795 50455919
Escherichia infection 25.18 9.55 75 134335 10866 50459848
Cushingoid 25.17 9.55 55 134355 6590 50464124
Drug reaction with eosinophilia and systemic symptoms 25.17 9.55 23 134387 28401 50442313
Pustular psoriasis 25.14 9.55 41 134369 3940 50466774
Blister 25.08 9.55 129 134281 85289 50385425
Presyncope 24.67 9.55 17 134393 24181 50446533
Angiosarcoma 24.60 9.55 12 134398 213 50470501
Infertility 24.51 9.55 17 134393 596 50470118
Product use complaint 24.50 9.55 27 134383 1775 50468939
Lethargy 24.33 9.55 60 134350 49372 50421342
Guttate psoriasis 24.32 9.55 14 134396 352 50470362
Gastropleural fistula 24.32 9.55 8 134402 46 50470668
Pseudomonal sepsis 24.31 9.55 29 134381 2078 50468636
Gastrointestinal mucormycosis 24.30 9.55 12 134398 219 50470495
Hilar lymphadenopathy 24.24 9.55 21 134389 1026 50469688
Nasal septum disorder 24.16 9.55 10 134400 118 50470596
Respiratory failure 24.15 9.55 358 134052 90823 50379891
Morphoea 24.14 9.55 13 134397 286 50470428
Fibroadenoma of breast 24.03 9.55 14 134396 360 50470354
Restlessness 23.96 9.55 19 134391 25154 50445560
Lymphocytic infiltration 23.81 9.55 19 134391 827 50469887
Eye complication associated with device 23.74 9.55 6 134404 10 50470704
Hepatosplenomegaly 23.73 9.55 30 134380 2282 50468432
Microsporidia infection 23.67 9.55 12 134398 232 50470482
Hepatic cirrhosis 23.64 9.55 101 134309 17476 50453238
Heart rate increased 23.63 9.55 115 134295 77135 50393579
Complications of transplanted heart 23.62 9.55 8 134402 51 50470663
Angiocentric lymphoma 23.60 9.55 16 134394 540 50470174
Pneumonia lipoid 23.57 9.55 10 134400 126 50470588
Prescribed overdose 23.54 9.55 5 134405 14595 50456119
Retinal haemorrhage 23.46 9.55 43 134367 4538 50466176
Plasmablastic lymphoma 23.30 9.55 11 134399 181 50470533
Post transplant distal limb syndrome 23.30 9.55 11 134399 181 50470533
Abdominal pain 23.22 9.55 465 133945 235763 50234951
Burkholderia cepacia complex infection 23.09 9.55 10 134400 133 50470581
Stenotrophomonas sepsis 22.96 9.55 7 134403 30 50470684
Growth failure 22.94 9.55 13 134397 317 50470397
Brain abscess 22.92 9.55 26 134384 1765 50468949
Fungal infection 22.80 9.55 147 134263 29818 50440896
Transaminases increased 22.73 9.55 139 134271 27685 50443029
Engraftment syndrome 22.72 9.55 13 134397 323 50470391
Bronchostenosis 22.66 9.55 14 134396 402 50470312
Haemosiderosis 22.56 9.55 11 134399 195 50470519
Lichenification 22.41 9.55 14 134396 410 50470304
Night sweats 22.40 9.55 34 134376 33540 50437174
Injection site pruritus 22.37 9.55 46 134364 40365 50430349
Transurethral bladder resection 22.33 9.55 5 134405 3 50470711
Hypertension 22.30 9.55 726 133684 210477 50260237
Bacterial infection 22.24 9.55 94 134316 16187 50454527
Tremor 22 9.55 197 134213 114706 50356008
Injection site swelling 21.92 9.55 49 134361 41724 50428990
Globulins decreased 21.87 9.55 11 134399 209 50470505
Capillary leak syndrome 21.78 9.55 26 134384 1864 50468850
Infusion related reaction 21.76 9.55 318 134092 169239 50301475
Alopecia scarring 21.76 9.55 9 134401 106 50470608
Iron overload 21.75 9.55 17 134393 718 50469996
Product packaging quantity issue 21.71 9.55 20 134390 1060 50469654
Penicillium infection 21.61 9.55 9 134401 108 50470606
Fungal endocarditis 21.59 9.55 11 134399 215 50470499
Staphylococcal bacteraemia 21.55 9.55 43 134367 4834 50465880
Lacrimation decreased 21.46 9.55 13 134397 360 50470354
Abdominal distension 21.46 9.55 110 134300 72793 50397921
Hepatitis E 21.36 9.55 21 134389 1208 50469506
Impaired work ability 21.33 9.55 5 134405 13635 50457079
MELAS syndrome 21.31 9.55 9 134401 112 50470602
Hypersensitivity 21.30 9.55 423 133987 214738 50255976
Rectal haemorrhage 21.25 9.55 44 134366 38514 50432200
Hyperplasia 21.24 9.55 17 134393 743 50469971
Pruritus allergic 21.09 9.55 20 134390 1100 50469614
Vertigo 21.03 9.55 69 134341 51763 50418951
Skin laceration 20.91 9.55 12 134398 18830 50451884
Ventricular tachycardia 20.76 9.55 8 134402 15813 50454901
Serotonin syndrome 20.71 9.55 21 134389 24692 50446022
Central obesity 20.69 9.55 19 134391 1003 50469711
Laser therapy 20.63 9.55 6 134404 21 50470693
Haemorrhage intracranial 20.58 9.55 76 134334 12298 50458416
Poisoning 20.57 9.55 4 134406 12425 50458289
Rectal cancer metastatic 20.55 9.55 11 134399 239 50470475
Rash pustular 20.53 9.55 50 134360 6431 50464283
Blood pressure fluctuation 20.50 9.55 40 134370 35783 50434931
Muscle spasticity 20.46 9.55 10 134400 17174 50453540
Tachycardia 20.46 9.55 168 134242 99595 50371119
Gait disturbance 20.43 9.55 278 134132 149727 50320987
Corneal lesion 20.42 9.55 6 134404 22 50470692
Anuria 20.36 9.55 71 134339 11173 50459541
Encephalitis 20.33 9.55 54 134356 7326 50463388
Genital cyst 20.23 9.55 7 134403 48 50470666
Apoptosis 20.15 9.55 8 134402 84 50470630
Microangiopathic haemolytic anaemia 20.15 9.55 14 134396 492 50470222
Hip arthroplasty 20.13 9.55 31 134379 30398 50440316
Neoplasm recurrence 20.10 9.55 28 134382 2341 50468373
Road traffic accident 20.06 9.55 21 134389 24331 50446383
Corynebacterium infection 19.98 9.55 13 134397 409 50470305
Leukaemia in remission 19.91 9.55 5 134405 8 50470706
Madarosis 19.86 9.55 29 134381 2531 50468183
Expired product administered 19.77 9.55 44 134366 5338 50465376
Renal disorder 19.75 9.55 133 134277 27372 50443342
Eyelid margin crusting 19.75 9.55 16 134394 712 50470002
Underdose 19.69 9.55 15 134395 20263 50450451
Blood glucose decreased 19.65 9.55 12 134398 18199 50452515
Progressive multifocal leukoencephalopathy 19.59 9.55 71 134339 11386 50459328
Papilloedema 19.58 9.55 34 134376 3439 50467275
Head injury 19.47 9.55 21 134389 23999 50446715
Metastases to liver 19.36 9.55 15 134395 20089 50450625
Foot fracture 19.33 9.55 15 134395 20076 50450638
Stenotrophomonas infection 19.30 9.55 23 134387 1646 50469068
Infection reactivation 19.30 9.55 18 134392 969 50469745
Torsade de pointes 19.19 9.55 4 134406 11831 50458883
Renal cortical necrosis 19.13 9.55 8 134402 97 50470617
Infected dermal cyst 19.12 9.55 13 134397 441 50470273
Red blood cell abnormality 19.01 9.55 12 134398 358 50470356
Coma 18.99 9.55 82 134328 56797 50413917
Thrombosis 18.94 9.55 80 134330 55753 50414961
Cryptococcosis 18.94 9.55 17 134393 871 50469843
Adenoviral haemorrhagic cystitis 18.74 9.55 9 134401 154 50470560
Hyperbilirubinaemia 18.71 9.55 62 134348 9508 50461206
Intervertebral disc protrusion 18.66 9.55 16 134394 20377 50450337
Groin pain 18.64 9.55 59 134351 8832 50461882
Chorioretinal folds 18.58 9.55 5 134405 12 50470702
Cellulitis staphylococcal 18.54 9.55 15 134395 666 50470048
Oesophageal candidiasis 18.54 9.55 41 134369 4953 50465761
American trypanosomiasis 18.49 9.55 7 134403 64 50470650
Metastatic malignant melanoma 18.46 9.55 19 134391 1155 50469559
Weight decreased 18.43 9.55 447 133963 220798 50249916
Sinus bradycardia 18.43 9.55 6 134404 13177 50457537
Urinary incontinence 18.40 9.55 29 134381 28179 50442535
Primary hypogonadism 18.38 9.55 9 134401 161 50470553
Hypertensive encephalopathy 18.35 9.55 14 134396 570 50470144
Phaeohyphomycosis 18.28 9.55 10 134400 227 50470487
Cytogenetic abnormality 18.25 9.55 13 134397 476 50470238
Emotional distress 18.20 9.55 30 134380 28633 50442081
Glomerulonephritis membranoproliferative 18.18 9.55 9 134401 165 50470549
Concomitant disease aggravated 18.18 9.55 55 134355 8036 50462678
Respiratory tract infection fungal 18.10 9.55 12 134398 390 50470324
Gastrointestinal disorder 18.05 9.55 162 134248 94294 50376420
Metapneumovirus infection 18.05 9.55 16 134394 806 50469908
Fear 18.05 9.55 8 134402 14541 50456173
Peripheral T-cell lymphoma unspecified 18.04 9.55 9 134401 168 50470546
Adenovirus reactivation 18.04 9.55 8 134402 113 50470601
Lysozyme increased 18.03 9.55 5 134405 14 50470700
Cholelithiasis 17.98 9.55 47 134363 37926 50432788
Plasma cell myeloma 17.90 9.55 35 134375 31287 50439427
Renal transplant 17.86 9.55 19 134391 1200 50469514
Overdose 17.79 9.55 174 134236 99553 50371161
Clonal evolution 17.76 9.55 7 134403 72 50470642
Dermatitis 17.73 9.55 80 134330 14171 50456543
Mycobacterium kansasii infection 17.61 9.55 8 134402 120 50470594
Primary effusion lymphoma 17.50 9.55 4 134406 3 50470711
Sinus disorder 17.48 9.55 14 134396 18444 50452270
Chronic spontaneous urticaria 17.44 9.55 13 134397 511 50470203
Caesarean section 17.41 9.55 85 134325 15554 50455160
Diabetic macroangiopathy 17.37 9.55 8 134402 124 50470590
Biopsy kidney abnormal 17.36 9.55 6 134404 41 50470673
Hypertrophy of tongue papillae 17.31 9.55 5 134405 17 50470697
Abnormal behaviour 17.29 9.55 16 134394 19642 50451072
Adjusted calcium decreased 17.26 9.55 8 134402 126 50470588
Vaginal haemorrhage 17.23 9.55 24 134386 24527 50446187
Coronary artery disease 17.17 9.55 33 134377 29693 50441021
Throat tightness 17.15 9.55 18 134392 20829 50449885
Peritonitis 17.12 9.55 84 134326 15402 50455312
Sleep disorder 17.10 9.55 86 134324 57197 50413517
Withdrawal syndrome 17.09 9.55 13 134397 17577 50453137
Septic vasculitis 16.97 9.55 4 134406 4 50470710
Moraxella infection 16.94 9.55 11 134399 345 50470369
Alpha haemolytic streptococcal infection 16.85 9.55 16 134394 881 50469833
Weber tuning fork test abnormal 16.80 9.55 7 134403 84 50470630
Papilloma viral infection 16.77 9.55 19 134391 1288 50469426
Device issue 16.71 9.55 17 134393 19955 50450759
Haemolysis 16.55 9.55 44 134366 5972 50464742
Chloroma 16.55 9.55 9 134401 202 50470512
Procedural pain 16.55 9.55 8 134402 13824 50456890
Full blood count decreased 16.54 9.55 21 134389 22325 50448389
Prescribed underdose 16.53 9.55 11 134399 15938 50454776
Restless legs syndrome 16.43 9.55 11 134399 15886 50454828
Epistaxis 16.38 9.55 101 134309 63853 50406861
Immunosuppression 16.24 9.55 50 134360 7376 50463338
Septic embolus 16.20 9.55 15 134395 800 50469914
Urinary retention 16.09 9.55 28 134382 26162 50444552
Muscular weakness 16.03 9.55 168 134242 94845 50375869
Skin lesion removal 16.03 9.55 6 134404 53 50470661
Parvovirus B19 infection 16.03 9.55 12 134398 475 50470239
Therapy interrupted 15.91 9.55 18 134392 20134 50450580
Liver disorder 15.91 9.55 160 134250 37062 50433652
Injection site haemorrhage 15.86 9.55 20 134390 21326 50449388
Transitional cell carcinoma 15.84 9.55 13 134397 589 50470125
Haematemesis 15.83 9.55 31 134379 27694 50443020
Lacrimal disorder 15.82 9.55 9 134401 221 50470493
Dyspnoea exertional 15.82 9.55 76 134334 51157 50419557
Human herpesvirus 8 infection 15.79 9.55 9 134401 222 50470492
Migraine 15.79 9.55 126 134284 75154 50395560
Pyelonephritis 15.65 9.55 80 134330 14909 50455805
Nephrolithiasis 15.63 9.55 44 134366 34649 50436065
Psychotic disorder 15.63 9.55 21 134389 21791 50448923
Fungal test positive 15.62 9.55 12 134398 494 50470220
Panic attack 15.58 9.55 17 134393 19325 50451389
Haematochezia 15.56 9.55 54 134356 39828 50430886
Neuropathy peripheral 15.55 9.55 173 134237 96584 50374130
Cerebral vasoconstriction 15.50 9.55 16 134394 976 50469738
Corneal abrasion 15.49 9.55 15 134395 847 50469867
Upper gastrointestinal haemorrhage 15.39 9.55 12 134398 16023 50454691
Hepatic failure 15.39 9.55 142 134268 32141 50438573
Gastroenteritis norovirus 15.35 9.55 21 134389 1726 50468988
Complication associated with device 15.34 9.55 10 134400 14645 50456069
Adverse drug reaction 15.32 9.55 85 134325 55137 50415577
Conjunctival hyperaemia 15.31 9.55 23 134387 2059 50468655
Treatment noncompliance 15.31 9.55 36 134374 30114 50440600
Product use issue 15.29 9.55 512 133898 148963 50321751
Myelodysplastic syndrome 15.27 9.55 80 134330 15052 50455662
B-cell lymphoma 15.26 9.55 28 134382 2957 50467757
Pterygium 15.23 9.55 8 134402 167 50470547
Diabetic ketoacidosis 15.19 9.55 15 134395 17857 50452857
Aspergillus test positive 15.19 9.55 10 134400 321 50470393
Lung consolidation 15.14 9.55 32 134378 3748 50466966
Myocarditis 15.10 9.55 51 134359 7896 50462818
Conjunctival oedema 15.10 9.55 13 134397 630 50470084
Rheumatoid lung 15.04 9.55 25 134385 2440 50468274
Exercise tolerance increased 15.02 9.55 5 134405 30 50470684
Type IIb hyperlipidaemia 15.02 9.55 5 134405 30 50470684
Unevaluable event 15.02 9.55 67 134343 45999 50424715
Oliguria 14.98 9.55 52 134358 8164 50462550
Rhabdomyolysis 14.91 9.55 164 134246 38863 50431851
Pulmonary alveolar haemorrhage 14.88 9.55 33 134377 3994 50466720
Pneumonia bacterial 14.87 9.55 48 134362 7261 50463453
Ewing's sarcoma recurrent 14.80 9.55 3 134407 0 50470714
Cord blood transplant therapy 14.80 9.55 3 134407 0 50470714
Cystostomy 14.80 9.55 3 134407 0 50470714
Punctal plug insertion 14.80 9.55 3 134407 0 50470714
Aqueous humour leakage 14.80 9.55 3 134407 0 50470714
Palmar-plantar erythrodysaesthesia syndrome 14.76 9.55 19 134391 20079 50450635
Klebsiella sepsis 14.73 9.55 17 134393 1176 50469538
Haemorrhagic cyst 14.69 9.55 8 134402 180 50470534
Obstructive airways disorder 14.67 9.55 12 134398 15640 50455074
Laparotomy 14.65 9.55 8 134402 181 50470533
Hepatitis B 14.65 9.55 30 134380 3436 50467278
Eyelid pain 14.64 9.55 9 134401 256 50470458
Tongue ulceration 14.63 9.55 28 134382 3052 50467662
Oral lichenoid reaction 14.63 9.55 6 134404 69 50470645
Myoglobinuria 14.55 9.55 9 134401 259 50470455
Hallucination 14.53 9.55 69 134341 46588 50424126
Adverse reaction 14.50 9.55 53 134357 8533 50462181
Hepatomegaly 14.50 9.55 62 134348 10731 50459983
Mycobacterium fortuitum infection 14.49 9.55 5 134405 34 50470680
Jejunal ulcer perforation 14.36 9.55 5 134405 35 50470679
Infection masked 14.36 9.55 5 134405 35 50470679
Laryngeal mass 14.36 9.55 5 134405 35 50470679
Drug level decreased 14.30 9.55 44 134366 6489 50464225
Metastases to bone 14.29 9.55 16 134394 17979 50452735
Tooth infection 14.27 9.55 10 134400 14102 50456612
Instillation site dryness 14.22 9.55 4 134406 12 50470702
Dry eye 14.22 9.55 139 134271 31956 50438758
Ureteric stenosis 14.19 9.55 12 134398 567 50470147
Atypical mycobacterial infection 14.03 9.55 14 134396 820 50469894
Pancreas transplant rejection 14.01 9.55 7 134403 131 50470583
CSF protein increased 14.00 9.55 11 134399 468 50470246
Depressed mood 14 9.55 45 134365 33978 50436736
Periportal oedema 13.98 9.55 4 134406 13 50470701
Still's disease 13.98 9.55 4 134406 13 50470701
Reticulocytosis 13.92 9.55 7 134403 133 50470581
Pneumonia herpes viral 13.90 9.55 5 134405 39 50470675
Hepatic fibrosis 13.87 9.55 28 134382 3174 50467540
Hepatitis B reactivation 13.87 9.55 22 134388 2065 50468649
Megakaryocytes increased 13.79 9.55 5 134405 40 50470674
Chronic myeloid leukaemia recurrent 13.72 9.55 8 134402 206 50470508
Glomerulonephropathy 13.71 9.55 6 134404 82 50470632
Skin haemorrhage 13.68 9.55 45 134365 6873 50463841
Intracranial pressure increased 13.68 9.55 33 134377 4219 50466495
Mucosal ulceration 13.67 9.55 14 134396 846 50469868
Hypotony of eye 13.64 9.55 7 134403 139 50470575
Lipohypertrophy 13.60 9.55 12 134398 601 50470113
Stevens-Johnson syndrome 13.60 9.55 23 134387 21729 50448985
Mania 13.54 9.55 6 134404 10910 50459804
Eyelid disorder 13.54 9.55 17 134393 1284 50469430
Fasciitis 13.53 9.55 11 134399 492 50470222
Heart rate irregular 13.51 9.55 19 134391 19341 50451373
Mycoplasma infection 13.44 9.55 10 134400 392 50470322
Guillain-Barre syndrome 13.42 9.55 29 134381 3448 50467266
Acute myeloid leukaemia 13.40 9.55 77 134333 14997 50455717
Eye infection staphylococcal 13.37 9.55 5 134405 44 50470670
Endotracheal intubation 13.35 9.55 22 134388 2132 50468582
Blindness cortical 13.35 9.55 10 134400 396 50470318
Pneumothorax 13.35 9.55 73 134337 13961 50456753
Ureteral neoplasm 13.34 9.55 4 134406 16 50470698
Infective chondritis 13.34 9.55 4 134406 16 50470698
Clonic convulsion 13.32 9.55 12 134398 618 50470096
Staphylococcal sepsis 13.24 9.55 45 134365 6991 50463723
Renal cell carcinoma 13.20 9.55 27 134383 3090 50467624
Bronchospasm 13.17 9.55 12 134398 14842 50455872
Immunodeficiency 13.13 9.55 12 134398 14816 50455898
Cholangitis 13.12 9.55 34 134376 4545 50466169
Hypertrophic cardiomyopathy 13.09 9.55 17 134393 1328 50469386
Osteoporotic fracture 13.03 9.55 27 134383 3118 50467596
Eating disorder 13.02 9.55 13 134397 15396 50455318
Intervertebral disc degeneration 13.02 9.55 10 134400 13451 50457263
Pregnancy 12.97 9.55 38 134372 29539 50441175
Disseminated Bacillus Calmette-Guerin infection 12.96 9.55 4 134406 18 50470696
Psychomotor disadaptation syndrome 12.96 9.55 4 134406 18 50470696
Occult blood 12.93 9.55 16 134394 1191 50469523
White blood cell count decreased 12.93 9.55 225 134185 116497 50354217
Central nervous system lymphoma 12.90 9.55 17 134393 1348 50469366
Erythrodermic psoriasis 12.87 9.55 14 134396 907 50469807
Foetal exposure during pregnancy 12.85 9.55 34 134376 27325 50443389
Blood calcium decreased 12.84 9.55 22 134388 20684 50450030
Encephalitis cytomegalovirus 12.81 9.55 11 134399 531 50470183
Toe amputation 12.77 9.55 20 134390 1857 50468857
Congenital coronary artery malformation 12.75 9.55 6 134404 98 50470616
Rheumatic disorder 12.74 9.55 18 134392 1525 50469189
Kidney anastomosis 12.73 9.55 3 134407 3 50470711
Nail pterygium 12.73 9.55 3 134407 3 50470711
Carcinoid tumour of the gastrointestinal tract 12.73 9.55 3 134407 3 50470711
Removal of transplanted organ 12.73 9.55 3 134407 3 50470711
Intestinal ulcer perforation 12.73 9.55 3 134407 3 50470711
Coxsackie virus test positive 12.73 9.55 3 134407 3 50470711
Keratolysis exfoliativa acquired 12.73 9.55 3 134407 3 50470711
Aplasia 12.71 9.55 30 134380 3783 50466931
Ocular vascular disorder 12.69 9.55 9 134401 327 50470387
Human herpes virus 6 serology positive 12.69 9.55 6 134404 99 50470615
Acid base balance abnormal 12.66 9.55 8 134402 239 50470475
Myopathy 12.66 9.55 53 134357 9086 50461628
Encapsulating peritoneal sclerosis 12.64 9.55 9 134401 329 50470385
Tongue pigmentation 12.62 9.55 4 134406 20 50470694
Live birth 12.59 9.55 15 134395 16393 50454321
Serratia infection 12.54 9.55 13 134397 797 50469917
Glomerulonephritis proliferative 12.52 9.55 7 134403 166 50470548
Device malfunction 12.50 9.55 13 134397 15108 50455606
Respiratory gas exchange disorder 12.46 9.55 9 134401 337 50470377
Reticulocyte count increased 12.43 9.55 13 134397 805 50469909
Pericardial effusion 12.42 9.55 113 134297 25476 50445238
Incorrect dose administered 12.39 9.55 189 134221 48225 50422489
Breast cancer metastatic 12.39 9.55 6 134404 10358 50460356
Genital discomfort 12.39 9.55 5 134405 55 50470659
Renal haematoma 12.30 9.55 7 134403 172 50470542
Escherichia sepsis 12.28 9.55 32 134378 4292 50466422
Juvenile idiopathic arthritis 12.26 9.55 25 134385 2854 50467860
Bronchiectasis 12.25 9.55 57 134353 10226 50460488
Autoimmune thyroiditis 12.23 9.55 27 134383 3258 50467456
Skin toxicity 12.20 9.55 30 134380 3883 50466831
Parakeratosis 12.09 9.55 8 134402 259 50470455
Hypocalcaemia 12.09 9.55 34 134376 26782 50443932
Vascular pseudoaneurysm ruptured 12.08 9.55 5 134405 59 50470655
Cardiac valve vegetation 12.07 9.55 8 134402 260 50470454
Pneumonia adenoviral 12.01 9.55 4 134406 24 50470690
Extubation 12.01 9.55 4 134406 24 50470690
Leukodystrophy 12.01 9.55 4 134406 24 50470690
Entropion 12.01 9.55 4 134406 24 50470690
Vascular graft complication 12.01 9.55 4 134406 24 50470690
Bone marrow myelogram abnormal 12.01 9.55 4 134406 24 50470690
Small intestinal obstruction 12.00 9.55 15 134395 16053 50454661
Pneumonia klebsiella 11.99 9.55 20 134390 1958 50468756
Muscle twitching 11.95 9.55 14 134396 15417 50455297
Secondary hypertension 11.93 9.55 6 134404 114 50470600
Perinephric collection 11.88 9.55 6 134404 115 50470599
Ciliary body disorder 11.88 9.55 4 134406 25 50470689
Ophthalmic herpes simplex 11.87 9.55 9 134401 363 50470351
Epidermodysplasia verruciformis 11.86 9.55 5 134405 62 50470652
Hyperthyroidism 11.83 9.55 9 134401 12166 50458548
Squamous cell carcinoma of the cervix 11.77 9.55 8 134402 271 50470443
Renal cancer 11.75 9.55 28 134382 3552 50467162
Choroidal detachment 11.75 9.55 7 134403 188 50470526
Candida pneumonia 11.74 9.55 6 134404 118 50470596
Erythropoiesis abnormal 11.67 9.55 8 134402 275 50470439
Pyogenic granuloma 11.62 9.55 8 134402 277 50470437
Eosinophilic pustular folliculitis 11.62 9.55 4 134406 27 50470687
Hip fracture 11.60 9.55 33 134377 25898 50444816
Vesicoureteric reflux 11.58 9.55 7 134403 193 50470521
Cryptococcal meningoencephalitis 11.58 9.55 5 134405 66 50470648
Adenoviral encephalitis 11.52 9.55 3 134407 6 50470708
Blood gonadotrophin increased 11.52 9.55 3 134407 6 50470708
Gallbladder rupture 11.49 9.55 9 134401 381 50470333
Injection site induration 11.43 9.55 4 134406 8393 50462321
Necrosis 11.41 9.55 33 134377 4703 50466011
Low birth weight baby 11.41 9.55 38 134372 5843 50464871
Rib fracture 11.40 9.55 21 134389 19200 50451514
Cytomegalovirus gastrointestinal infection 11.40 9.55 8 134402 286 50470428
Acute disseminated encephalomyelitis 11.39 9.55 7 134403 199 50470515
Skin hypopigmentation 11.37 9.55 11 134399 620 50470094
Dyschromatopsia 11.33 9.55 9 134401 389 50470325
Dry mouth 11.33 9.55 95 134315 56083 50414631
Upper respiratory tract infection 11.32 9.55 116 134294 65782 50404932
Pre-existing condition improved 11.31 9.55 43 134367 7054 50463660
Superinfection bacterial 11.26 9.55 10 134400 505 50470209
Peripheral artery aneurysm 11.25 9.55 4 134406 30 50470684
Actinomycotic sepsis 11.25 9.55 5 134405 71 50470643
Injection site extravasation 11.24 9.55 3 134407 7498 50463216
Plantar fascial fibromatosis 11.22 9.55 6 134404 130 50470584
Cutaneous mucormycosis 11.21 9.55 3 134407 7 50470707
Urticaria pressure 11.21 9.55 3 134407 7 50470707
Renal vein thrombosis 11.18 9.55 8 134402 295 50470419
Eyelid skin dryness 11.13 9.55 5 134405 73 50470641
Dysmetria 11.12 9.55 9 134401 400 50470314
Mental status changes 11.09 9.55 54 134356 36218 50434496
Extrapyramidal disorder 11.06 9.55 9 134401 11761 50458953
Skin hyperpigmentation 11.05 9.55 35 134375 5241 50465473
Pain in jaw 11.01 9.55 153 134257 38275 50432439
Disturbance in attention 11.00 9.55 44 134366 31142 50439572
Reversible cerebral vasoconstriction syndrome 10.99 9.55 20 134390 2099 50468615
Therapy cessation 10.99 9.55 34 134376 25977 50444737
Lower limb fracture 10.95 9.55 13 134397 14233 50456481
Genital lesion 10.94 9.55 7 134403 214 50470500
Lymphadenopathy mediastinal 10.93 9.55 22 134388 2489 50468225
Hepatitis C virus test 10.92 9.55 3 134407 8 50470706
Arrhythmia 10.91 9.55 48 134362 33084 50437630
Tanning 10.89 9.55 5 134405 77 50470637
Febrile neutropenia 10.88 9.55 338 134072 97329 50373385
Keratoacanthoma 10.80 9.55 9 134401 417 50470297
Corneal transplant 10.79 9.55 7 134403 219 50470495
Dehiscence 10.77 9.55 5 134405 79 50470635
Pallor 10.77 9.55 29 134381 23170 50447544
Nail dystrophy 10.77 9.55 12 134398 799 50469915
Cholestasis 10.76 9.55 109 134301 25292 50445422
Legionella infection 10.76 9.55 9 134401 419 50470295
CD4 lymphocytes increased 10.75 9.55 6 134404 142 50470572
Hepatic haematoma 10.72 9.55 9 134401 421 50470293
Device breakage 10.71 9.55 6 134404 9541 50461173
Right ventricular failure 10.69 9.55 16 134394 15877 50454837
Gingival swelling 10.69 9.55 28 134382 3767 50466947
Amnesia 10.68 9.55 67 134343 42193 50428521
Lichen planus 10.67 9.55 19 134391 1960 50468754
Removal of renal transplant 10.67 9.55 3 134407 9 50470705
Pharyngeal necrosis 10.67 9.55 3 134407 9 50470705
Glutamate dehydrogenase level abnormal 10.67 9.55 3 134407 9 50470705
Arteriosclerotic retinopathy 10.67 9.55 3 134407 9 50470705
Acute hepatitis C 10.66 9.55 5 134405 81 50470633
Meningoradiculitis 10.66 9.55 5 134405 81 50470633
Tuberculosis 10.65 9.55 54 134356 10029 50460685
Diffuse alveolar damage 10.63 9.55 12 134398 810 50469904
Punctate keratitis 10.59 9.55 10 134400 547 50470167
Central nervous system vasculitis 10.56 9.55 12 134398 816 50469898
Anal incontinence 10.53 9.55 9 134401 11481 50459233
Squamous cell carcinoma of skin 10.53 9.55 34 134376 5144 50465570
Post procedural urine leak 10.52 9.55 4 134406 37 50470677
Feeling hot 10.51 9.55 61 134349 39141 50431573
Cyanosis 10.50 9.55 15 134395 15169 50455545
Follicular lymphoma 10.44 9.55 5 134405 85 50470629
Thyroglossal cyst infection 10.43 9.55 4 134406 38 50470676
Meningitis cryptococcal 10.42 9.55 14 134396 1131 50469583
Faecaloma 10.36 9.55 3 134407 7105 50463609
Swollen tongue 10.35 9.55 40 134370 28590 50442124
Cutaneous lymphoma 10.35 9.55 6 134404 153 50470561
Fracture 10.34 9.55 18 134392 16815 50453899
Gliosis 10.33 9.55 7 134403 236 50470478
Injection site warmth 10.29 9.55 13 134397 13853 50456861
Device related infection 10.29 9.55 92 134318 20643 50450071
Corneal erosion 10.28 9.55 7 134403 238 50470476
Anger 10.24 9.55 9 134401 11324 50459390
Photosensitivity reaction 10.23 9.55 64 134346 12847 50457867
Sleep apnoea syndrome 10.22 9.55 31 134379 23837 50446877
Megakaryocytes decreased 10.21 9.55 3 134407 11 50470703
Renal tubular disorder 10.19 9.55 21 134389 2416 50468298
Coccidioidomycosis 10.17 9.55 12 134398 850 50469864
CSF white blood cell count increased 10.16 9.55 4 134406 41 50470673
Red cell distribution width increased 10.16 9.55 5 134405 8554 50462160
Allergic transfusion reaction 10.16 9.55 4 134406 41 50470673
Genital neoplasm malignant female 10.14 9.55 5 134405 91 50470623
Renal artery thrombosis 10.14 9.55 5 134405 91 50470623
Aggression 10.10 9.55 26 134384 21090 50449624
Diabetes mellitus inadequate control 10.10 9.55 12 134398 13133 50457581
Capillaritis 10.09 9.55 5 134405 92 50470622
Laboratory test abnormal 10.04 9.55 30 134380 23178 50447536
Dyskinesia 10.03 9.55 39 134371 27822 50442892
Neoplasm malignant 10.01 9.55 31 134379 23684 50447030
Haemochromatosis 10.01 9.55 9 134401 462 50470252
Arterial disorder 10.01 9.55 13 134397 1016 50469698
Infestation 9.99 9.55 4 134406 43 50470671
Renal infarct 9.97 9.55 15 134395 1345 50469369
Varicella 9.95 9.55 17 134393 1697 50469017
Drug level changed 9.94 9.55 6 134404 165 50470549
Cat scratch disease 9.91 9.55 6 134404 166 50470548
Eosinophilic myocarditis 9.85 9.55 8 134402 357 50470357
Ischaemic stroke 9.84 9.55 17 134393 15931 50454783
Corneal perforation 9.83 9.55 9 134401 473 50470241
Escherichia bacteraemia 9.83 9.55 24 134386 3092 50467622
Diverticulitis 9.80 9.55 50 134360 33132 50437582
Oedema mucosal 9.78 9.55 12 134398 885 50469829
Concussion 9.77 9.55 4 134406 7624 50463090
Tooth extraction 9.76 9.55 6 134404 9069 50461645
Osteonecrosis 9.72 9.55 97 134313 22420 50448294
Anaplastic large cell lymphoma T- and null-cell types 9.68 9.55 4 134406 47 50470667
Eyelid sensory disorder 9.68 9.55 4 134406 47 50470667
Vaccination site inflammation 9.68 9.55 4 134406 47 50470667
Oesophageal perforation 9.64 9.55 7 134403 264 50470450
CD8 lymphocytes increased 9.63 9.55 3 134407 14 50470700
Ubiquinone decreased 9.63 9.55 3 134407 14 50470700
Bronchitis 9.63 9.55 207 134203 103952 50366762
Generalised oedema 9.62 9.55 66 134344 13665 50457049
Agranulocytosis 9.60 9.55 93 134317 21328 50449386
Focal nodular hyperplasia 9.60 9.55 9 134401 488 50470226
Cholecystitis chronic 9.58 9.55 7 134403 9662 50461052

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 1791.64 10.89 1098 108197 22117 29443115
Graft versus host disease 1197.65 10.89 623 108672 9005 29456227
Acute graft versus host disease 919.17 10.89 443 108852 5381 29459851
Product use in unapproved indication 888.97 10.89 1332 107963 85543 29379689
Acute graft versus host disease in skin 869.40 10.89 398 108897 4266 29460966
Chronic graft versus host disease 808.58 10.89 362 108933 3667 29461565
Epstein-Barr virus infection 681.39 10.89 378 108917 6251 29458981
Kidney transplant rejection 632.56 10.89 367 108928 6638 29458594
Post transplant lymphoproliferative disorder 624.93 10.89 335 108960 5158 29460074
Graft versus host disease in gastrointestinal tract 613.40 10.89 280 109015 2978 29462254
Posterior reversible encephalopathy syndrome 539.22 10.89 363 108932 8613 29456619
Transplant rejection 511.80 10.89 355 108940 8857 29456375
Nephropathy toxic 458.10 10.89 353 108942 10403 29454829
Graft versus host disease in skin 444.05 10.89 227 109068 3152 29462080
Acute graft versus host disease in intestine 440.08 10.89 201 109094 2140 29463092
BK virus infection 389.21 10.89 233 109062 4474 29460758
Cystitis haemorrhagic 365.24 10.89 226 109069 4616 29460616
Fatigue 353.81 10.89 391 108904 316430 29148802
Blood creatinine increased 349.74 10.89 888 108407 84214 29381018
Epstein-Barr virus associated lymphoproliferative disorder 335.45 10.89 152 109143 1586 29463646
Complications of transplanted kidney 319.86 10.89 193 109102 3761 29461471
Renal impairment 310.85 10.89 826 108469 80507 29384725
Thrombotic microangiopathy 303.85 10.89 254 109041 8427 29456805
Acute graft versus host disease in liver 296.75 10.89 129 109166 1209 29464023
Completed suicide 296.16 10.89 8 109287 90238 29374994
Dizziness 277.52 10.89 180 109115 189504 29275728
Drug abuse 270.21 10.89 5 109290 79878 29385354
Fall 267.63 10.89 162 109133 177016 29288216
Cytomegalovirus infection reactivation 251.14 10.89 156 109139 3208 29462024
Heart transplant rejection 248.85 10.89 109 109186 1042 29464190
Aspergillus infection 247.57 10.89 247 109048 10334 29454898
Chronic graft versus host disease in skin 245.40 10.89 98 109197 725 29464507
Immunosuppressant drug level increased 242.29 10.89 174 109121 4591 29460641
Bronchopulmonary aspergillosis 238.33 10.89 260 109035 12084 29453148
Cytomegalovirus viraemia 235.96 10.89 192 109103 6128 29459104
Gingival hypertrophy 233.80 10.89 117 109178 1548 29463684
Pneumonia cytomegaloviral 227.55 10.89 135 109160 2547 29462685
Adenovirus infection 227.52 10.89 163 109132 4284 29460948
Death 225.14 10.89 592 108703 341492 29123740
Hepatic function abnormal 223.32 10.89 466 108829 38793 29426439
Liver transplant rejection 203.99 10.89 113 109182 1861 29463371
Polyomavirus viraemia 189.07 10.89 76 109219 573 29464659
Multiple organ dysfunction syndrome 186.73 10.89 585 108710 62531 29402701
Graft versus host disease in liver 184.68 10.89 87 109208 999 29464233
Cytomegalovirus test positive 183.27 10.89 129 109166 3294 29461938
Hypotension 183.05 10.89 272 109023 194082 29271150
Drug eruption 181.11 10.89 264 109031 16477 29448755
Eye irritation 174.88 10.89 157 109138 5741 29459491
Haemophagocytic lymphohistiocytosis 171.77 10.89 203 109092 10301 29454931
Immunosuppressant drug level decreased 170.38 10.89 84 109211 1074 29464158
Obliterative bronchiolitis 170.32 10.89 83 109212 1033 29464199
Syncope 166.78 10.89 47 109248 81324 29383908
Transplant dysfunction 166.25 10.89 104 109191 2166 29463066
Transplant failure 165.51 10.89 113 109182 2743 29462489
Chronic allograft nephropathy 164.06 10.89 81 109214 1039 29464193
Mucormycosis 162.29 10.89 142 109153 5016 29460216
Pyrexia 162.18 10.89 1698 107597 285924 29179308
Dyspnoea 160.76 10.89 643 108652 326089 29139143
Product dose omission issue 158.57 10.89 79 109216 96304 29368928
Venoocclusive disease 153.19 10.89 103 109192 2436 29462796
Polyomavirus-associated nephropathy 152.35 10.89 115 109180 3281 29461951
Asthenia 151.72 10.89 359 108936 214891 29250341
Proteinuria 150.71 10.89 235 109060 15569 29449663
Drug ineffective 148.47 10.89 2016 107279 361154 29104078
Constipation 147.69 10.89 123 109172 114037 29351195
Squamous cell carcinoma 146.36 10.89 185 109110 10066 29455166
Pneumocystis jirovecii pneumonia 134.94 10.89 231 109064 16548 29448684
Oral administration complication 131.27 10.89 32 109263 21 29465211
Intentional overdose 127.89 10.89 3 109292 38525 29426707
Lymphoproliferative disorder 125.55 10.89 91 109204 2436 29462796
Chronic graft versus host disease in liver 123.82 10.89 47 109248 298 29464934
Stomatitis 123.82 10.89 359 108936 36754 29428478
Kidney fibrosis 121.01 10.89 82 109213 1965 29463267
Anxiety 120.57 10.89 84 109211 85281 29379951
Overdose 116.13 10.89 76 109219 79743 29385489
Human herpesvirus 6 infection 115.82 10.89 77 109218 1786 29463446
Lymphocele 115.49 10.89 68 109227 1264 29463968
Somnolence 114.53 10.89 107 109188 93848 29371384
Pain 113.58 10.89 295 109000 171137 29294095
Cardiac failure congestive 109.95 10.89 74 109221 76507 29388725
JC virus infection 109.79 10.89 75 109220 1822 29463410
Chronic graft versus host disease in intestine 106.25 10.89 37 109258 176 29465056
Mucosal inflammation 104.78 10.89 305 108990 31290 29433942
Complications of bone marrow transplant 104.11 10.89 37 109258 189 29465043
Disease recurrence 103.70 10.89 200 109095 15714 29449518
Bradycardia 101.71 10.89 58 109237 65571 29399661
Decreased appetite 98.63 10.89 247 109048 145095 29320137
Chest pain 97.38 10.89 165 109130 111808 29353424
Hyperhidrosis 97.24 10.89 59 109236 64481 29400751
Drug resistance 96.95 10.89 233 109062 21307 29443925
Viraemia 96.20 10.89 56 109239 1018 29464214
Lung transplant rejection 96.16 10.89 49 109246 675 29464557
Kaposi's sarcoma 93.63 10.89 51 109244 811 29464421
Venoocclusive liver disease 91.17 10.89 120 109175 6797 29458435
Myocardial infarction 90.97 10.89 168 109127 110128 29355104
Cerebrovascular accident 90.91 10.89 90 109205 76821 29388411
Renal transplant failure 90.03 10.89 52 109243 931 29464301
Therapy non-responder 89.93 10.89 285 109010 30626 29434606
End stage renal disease 88.95 10.89 125 109170 7539 29457693
Back pain 85.95 10.89 154 109141 102130 29363102
Malignant neoplasm progression 85.50 10.89 88 109207 73771 29391461
Neurotoxicity 84.83 10.89 175 109120 14438 29450794
Dehydration 84.21 10.89 187 109108 114561 29350671
Suicide attempt 83.58 10.89 13 109282 34097 29431135
Graft loss 83.41 10.89 47 109248 801 29464431
Hepatitis E 82.52 10.89 60 109235 1614 29463618
Progressive multifocal leukoencephalopathy 82.21 10.89 129 109166 8590 29456642
Cytomegalovirus chorioretinitis 82.09 10.89 79 109216 3159 29462073
Confusional state 81.63 10.89 224 109071 127653 29337579
Tenosynovitis 81.56 10.89 84 109211 3649 29461583
Pseudomonas infection 81.52 10.89 145 109150 10707 29454525
Acute myeloid leukaemia recurrent 81.45 10.89 61 109234 1719 29463513
Chronic obstructive pulmonary disease 81.41 10.89 25 109270 40930 29424302
Psoriasis 81.16 10.89 283 109012 31944 29433288
Hypoglycaemia 80.40 10.89 39 109256 48307 29416925
Diffuse large B-cell lymphoma 79.82 10.89 107 109188 6169 29459063
Graft versus host disease in lung 78.68 10.89 38 109257 463 29464769
Treatment failure 78.45 10.89 307 108988 36632 29428600
Fungal infection 78.39 10.89 163 109132 13522 29451710
Depression 78.20 10.89 121 109174 85026 29380206
Joint swelling 76.69 10.89 44 109251 49586 29415646
Focal segmental glomerulosclerosis 76.24 10.89 59 109236 1748 29463484
Injection site pain 75.89 10.89 14 109281 32432 29432800
Agitation 75.75 10.89 48 109247 51256 29413976
Engraftment syndrome 75.63 10.89 44 109251 799 29464433
Vein rupture 75.27 10.89 41 109254 652 29464580
Enterococcal infection 74.75 10.89 120 109175 8148 29457084
Electrocardiogram QT prolonged 73.76 10.89 21 109274 36116 29429116
Atrial fibrillation 73.61 10.89 177 109118 105469 29359763
Cardiac arrest 73.58 10.89 127 109168 85464 29379768
Haemodialysis 73.48 10.89 132 109163 9822 29455410
Rash 72.78 10.89 408 108887 189411 29275821
Hyponatraemia 72.31 10.89 86 109209 67547 29397685
Graft versus host disease in eye 72.21 10.89 29 109266 218 29465014
Renal tubular atrophy 72.00 10.89 46 109249 995 29464237
Pulmonary embolism 71.97 10.89 107 109188 76427 29388805
International normalised ratio increased 71.97 10.89 37 109258 44335 29420897
Enthesopathy 70.77 10.89 78 109217 3665 29461567
Herpes simplex 69.40 10.89 88 109207 4802 29460430
Bacterial infection 69.28 10.89 150 109145 12798 29452434
Hirsutism 69.01 10.89 26 109269 161 29465071
Aplasia pure red cell 68.90 10.89 93 109202 5398 29459834
Malaise 67.33 10.89 332 108963 159270 29305962
Complications of transplanted heart 67.18 10.89 28 109267 234 29464998
Skin plaque 67.02 10.89 76 109219 3686 29461546
Coombs positive haemolytic anaemia 66.80 10.89 39 109256 713 29464519
Weight increased 66.59 10.89 113 109182 76554 29388678
Unevaluable event 65.43 10.89 15 109280 29836 29435396
Acute myocardial infarction 65.31 10.89 50 109245 48388 29416844
Haemolysis 64.31 10.89 102 109193 6854 29458378
Blood bilirubin increased 64.28 10.89 272 109023 33621 29431611
Squamous cell carcinoma of skin 63.99 10.89 121 109174 9365 29455867
Hypogammaglobulinaemia 63.64 10.89 93 109202 5814 29459418
Weight decreased 63.02 10.89 315 108980 150590 29314642
Concomitant disease progression 62.50 10.89 59 109236 2302 29462930
Suicidal ideation 62.46 10.89 25 109270 34691 29430541
Insomnia 62.38 10.89 148 109147 88613 29376619
Neuropathy peripheral 62.32 10.89 104 109191 70923 29394309
Pneumonia fungal 62.31 10.89 91 109204 5686 29459546
Balance disorder 61.95 10.89 28 109267 36142 29429090
Hepatitis C 61.78 10.89 115 109180 8795 29456437
Aggression 61.68 10.89 27 109268 35514 29429718
Cutaneous T-cell lymphoma 60.70 10.89 45 109250 1248 29463984
Engraft failure 60.61 10.89 30 109265 387 29464845
Renal tubular necrosis 60.32 10.89 151 109144 14164 29451068
Cystitis viral 60.16 10.89 32 109263 484 29464748
Cardio-respiratory arrest 60.01 10.89 59 109236 50542 29414690
Toxicity to various agents 59.33 10.89 387 108908 173274 29291958
Nausea 59.17 10.89 735 108560 288520 29176712
Hospitalisation 57.63 10.89 51 109244 45937 29419295
Chorioretinopathy 57.07 10.89 45 109250 1371 29463861
Erythrodermic psoriasis 56.94 10.89 36 109259 764 29464468
Haemolytic uraemic syndrome 56.85 10.89 52 109243 1948 29463284
Hypokalaemia 56.75 10.89 61 109234 50142 29415090
Staphylococcal infection 56.49 10.89 236 109059 29004 29436228
Mycoplasma infection 56.49 10.89 26 109269 282 29464950
Intentional product misuse 56.06 10.89 29 109266 34632 29430600
Lactic acidosis 55.71 10.89 21 109274 30226 29435006
Hypersensitivity 55.41 10.89 360 108935 52543 29412689
Epstein-Barr viraemia 55.02 10.89 38 109257 940 29464292
Rectal haemorrhage 54.27 10.89 30 109265 34519 29430713
Spermatozoa progressive motility decreased 54.18 10.89 20 109275 116 29465116
Loss of consciousness 54.03 10.89 121 109174 73935 29391297
Pyogenic granuloma 54.00 10.89 23 109272 204 29465028
Peripheral swelling 53.47 10.89 96 109199 63643 29401589
Stem cell transplant 53.26 10.89 50 109245 1937 29463295
Viral test positive 52.97 10.89 22 109273 182 29465050
Cytomegalovirus colitis 52.94 10.89 55 109240 2414 29462818
Skin lesion 52.87 10.89 170 109125 18402 29446830
Serotonin syndrome 52.52 10.89 3 109292 17509 29447723
Nephrectomy 52.42 10.89 33 109262 695 29464537
Hypertension 51.66 10.89 658 108637 115956 29349276
Leukaemia recurrent 51.22 10.89 43 109252 1434 29463798
Diarrhoea 51.14 10.89 894 108401 331804 29133428
Chest discomfort 50.73 10.89 57 109238 45926 29419306
Nephrotic syndrome 50.70 10.89 87 109208 6241 29458991
Pneumomediastinum 50.59 10.89 46 109249 1710 29463522
Basal cell carcinoma 50.16 10.89 157 109138 16753 29448479
Bacillary angiomatosis 50.01 10.89 18 109277 96 29465136
Sedation 49.23 10.89 4 109291 17401 29447831
Thrombotic thrombocytopenic purpura 49.19 10.89 60 109235 3146 29462086
Alveolar proteinosis 49.01 10.89 24 109271 302 29464930
Vomiting 48.92 10.89 525 108770 211735 29253497
Flushing 48.79 10.89 23 109272 28969 29436263
Drug withdrawal syndrome 48.54 10.89 5 109290 17979 29447253
Tongue disorder 48.52 10.89 72 109223 4564 29460668
American trypanosomiasis 48.34 10.89 22 109273 232 29465000
Glomerulonephritis membranous 48.31 10.89 35 109260 936 29464296
Arthralgia 48.23 10.89 310 108985 139307 29325925
Hypertrichosis 47.92 10.89 24 109271 318 29464914
Wheezing 47.83 10.89 32 109263 33208 29432024
Bacterial sepsis 47.73 10.89 72 109223 4631 29460601
Drug level increased 47.30 10.89 165 109130 18622 29446610
Blood lactate dehydrogenase increased 46.90 10.89 167 109128 19042 29446190
Toxoplasmosis 46.84 10.89 37 109258 1130 29464102
Blood glucose increased 46.69 10.89 92 109203 58892 29406340
Sepsis 46.48 10.89 763 108532 141919 29323313
Cryptococcosis 46.44 10.89 46 109249 1906 29463326
Disseminated tuberculosis 46.24 10.89 46 109249 1916 29463316
Ureteric stenosis 46.13 10.89 36 109259 1080 29464152
Alternaria infection 45.97 10.89 23 109272 304 29464928
Venous injury 45.84 10.89 22 109273 264 29464968
Asthma 45.55 10.89 35 109260 33814 29431418
Complications of transplant surgery 45.38 10.89 26 109269 458 29464774
Microangiopathic haemolytic anaemia 45.25 10.89 32 109263 823 29464409
Sebaceous hyperplasia 44.72 10.89 14 109281 44 29465188
Mycobacterial infection 44.65 10.89 44 109251 1812 29463420
Blood beta-D-glucan increased 44.60 10.89 24 109271 372 29464860
Lung infiltration 44.23 10.89 119 109176 11660 29453572
Nocardiosis 43.65 10.89 57 109238 3203 29462029
Osteonecrosis of jaw 43.52 10.89 5 109290 16505 29448727
Hallucination 43.50 10.89 61 109234 44651 29420581
Dyspepsia 43.35 10.89 29 109266 30096 29435136
Alanine aminotransferase abnormal 43.21 10.89 54 109241 2903 29462329
Chronic graft versus host disease oral 42.95 10.89 14 109281 52 29465180
Haptoglobin decreased 42.92 10.89 26 109269 510 29464722
Pancytopenia 42.82 10.89 483 108812 82685 29382547
Viral haemorrhagic cystitis 42.53 10.89 32 109263 908 29464324
Cytomegalovirus syndrome 42.21 10.89 16 109279 101 29465131
Steroid diabetes 42.18 10.89 41 109254 1660 29463572
Escherichia infection 41.62 10.89 83 109212 6681 29458551
Drug reaction with eosinophilia and systemic symptoms 41.57 10.89 26 109269 27966 29437266
Cardiac disorder 41.31 10.89 46 109249 37217 29428015
Brain stem syndrome 41.23 10.89 23 109272 384 29464848
Rheumatoid arthritis 41.07 10.89 35 109260 32117 29433115
Scedosporium infection 40.67 10.89 29 109266 756 29464476
Blood stem cell transplant failure 40.66 10.89 23 109272 395 29464837
Trichophytic granuloma 40.58 10.89 13 109282 45 29465187
Glomerulosclerosis 40.56 10.89 28 109267 692 29464540
Wrong technique in product usage process 40.41 10.89 34 109261 31394 29433838
Renal failure 40.39 10.89 639 108656 117960 29347272
Coronary artery disease 40.35 10.89 63 109232 44127 29421105
Lymphadenitis 40.34 10.89 39 109256 1568 29463664
Rhabdomyolysis 40.32 10.89 372 108923 60436 29404796
Pneumatosis intestinalis 40.26 10.89 54 109241 3115 29462117
Deep vein thrombosis 40.07 10.89 96 109199 57303 29407929
Staphylococcal sepsis 40.01 10.89 96 109199 8766 29456466
Red blood cell schistocytes present 39.96 10.89 19 109276 223 29465009
Acute respiratory distress syndrome 39.62 10.89 179 109116 22756 29442476
Psoriatic arthropathy 39.59 10.89 132 109163 14559 29450673
Drug level changed 39.57 10.89 21 109274 316 29464916
Erectile dysfunction 39.56 10.89 9 109286 18000 29447232
Hypoaesthesia 39.28 10.89 87 109208 53380 29411852
Urinary retention 39.21 10.89 36 109259 31862 29433370
Drug hypersensitivity 39.14 10.89 126 109169 68280 29396952
Immunosuppression 38.89 10.89 70 109225 5216 29460016
Biopsy kidney abnormal 38.88 10.89 15 109280 100 29465132
Feeling abnormal 38.86 10.89 90 109205 54355 29410877
Adenoviral haemorrhagic cystitis 38.73 10.89 22 109273 381 29464851
Actinic keratosis 38.48 10.89 58 109237 3728 29461504
Encephalitis fungal 38.40 10.89 17 109278 167 29465065
Renal transplant 38.26 10.89 38 109257 1580 29463652
Smooth muscle cell neoplasm 38.15 10.89 16 109279 136 29465096
Instillation site pain 37.95 10.89 14 109281 81 29465151
Plasmablastic lymphoma 37.73 10.89 18 109277 213 29465019
Abdominal discomfort 37.67 10.89 75 109220 47828 29417404
Injection site erythema 37.36 10.89 4 109291 13952 29451280
Gait disturbance 37.34 10.89 142 109153 73207 29392025
Laparotomy 37.33 10.89 19 109276 261 29464971
Serum sickness 37.27 10.89 39 109256 1726 29463506
Apoptosis 37.22 10.89 18 109277 220 29465012
Epstein-Barr virus infection reactivation 37.21 10.89 24 109271 528 29464704
Encephalitis cytomegalovirus 37.10 10.89 23 109272 471 29464761
Candida infection 36.85 10.89 132 109163 15093 29450139
Cerebral toxoplasmosis 36.75 10.89 35 109260 1381 29463851
Herpes virus infection 36.63 10.89 46 109249 2485 29462747
Meningoencephalitis herpetic 36.63 10.89 27 109268 742 29464490
Palpitations 36.41 10.89 40 109255 32564 29432668
Ventricular tachycardia 36.33 10.89 19 109276 22555 29442677
Myopathy 36.17 10.89 103 109192 10430 29454802
Encephalitis 36.13 10.89 76 109219 6354 29458878
Dermatitis exfoliative generalised 35.99 10.89 49 109246 2867 29462365
Renal lymphocele 35.92 10.89 12 109283 49 29465183
Renal disorder 35.83 10.89 172 109123 22423 29442809
Bacteraemia 35.73 10.89 137 109158 16186 29449046
Tachycardia 35.69 10.89 142 109153 72268 29392964
Urine output decreased 35.36 10.89 94 109201 9144 29456088
Delirium 35.18 10.89 57 109238 39340 29425892
Systemic mycosis 34.95 10.89 33 109262 1288 29463944
Cushingoid 34.79 10.89 44 109251 2394 29462838
Gastrooesophageal reflux disease 34.78 10.89 39 109256 31457 29433775
Myopathy toxic 34.49 10.89 21 109274 416 29464816
Blood urea increased 34.28 10.89 199 109096 27913 29437319
Memory impairment 34.25 10.89 51 109244 36419 29428813
Urticaria 34.05 10.89 330 108965 54330 29410902
Glomerulonephropathy 34.02 10.89 16 109279 183 29465049
Tularaemia 33.78 10.89 13 109282 86 29465146
Epstein-Barr virus associated lymphoma 33.73 10.89 23 109272 557 29464675
Musculoskeletal stiffness 33.63 10.89 54 109241 37404 29427828
Respiratory depression 33.47 10.89 5 109290 13518 29451714
Head injury 33.45 10.89 9 109286 16072 29449160
Nasopharyngitis 33.37 10.89 111 109184 59554 29405678
Pruritus 33.30 10.89 274 109021 116575 29348657
Lymphadenopathy 32.97 10.89 181 109114 24868 29440364
Hyperplasia 32.91 10.89 22 109273 515 29464717
Injection site papule 32.67 10.89 18 109277 293 29464939
Pustular psoriasis 32.58 10.89 34 109261 1500 29463732
Endoscopic retrograde cholangiopancreatography 32.38 10.89 8 109287 6 29465226
Diabetes mellitus 32.37 10.89 255 109040 39576 29425656
Foreign body sensation in eyes 32.32 10.89 22 109273 531 29464701
Human herpesvirus 8 infection 32.18 10.89 26 109269 821 29464411
Oliguria 32.08 10.89 79 109216 7333 29457899
Atypical mycobacterial pneumonia 32.03 10.89 14 109281 133 29465099
Achromobacter infection 31.99 10.89 11 109284 50 29465182
Eye pain 31.97 10.89 105 109190 11490 29453742
Drug dependence 31.83 10.89 19 109276 20962 29444270
Mechanical ventilation 31.74 10.89 35 109260 1645 29463587
Reticulocyte count increased 31.74 10.89 21 109274 483 29464749
Chronic myeloid leukaemia 31.71 10.89 38 109257 1956 29463276
Cutaneous mucormycosis 31.68 10.89 13 109282 104 29465128
Diabetic ketoacidosis 31.59 10.89 10 109285 16063 29449169
Glomerulonephritis 31.40 10.89 35 109260 1665 29463567
Skin mass 31.16 10.89 50 109245 3393 29461839
Life support 31.15 10.89 14 109281 143 29465089
Plasma cell myeloma 31.03 10.89 56 109239 37059 29428173
Abnormal behaviour 31.00 10.89 24 109271 23103 29442129
Eosinophilia 31.00 10.89 22 109273 22139 29443093
Legionella infection 30.96 10.89 20 109275 441 29464791
Scleroderma 30.85 10.89 31 109264 1307 29463925
Therapeutic response decreased 30.83 10.89 176 109119 24535 29440697
C-reactive protein abnormal 30.80 10.89 72 109223 6464 29458768
Epstein-Barr virus antibody positive 30.79 10.89 17 109278 278 29464954
Heart rate decreased 30.76 10.89 28 109267 24884 29440348
Lymphocytic infiltration 30.54 10.89 22 109273 583 29464649
Fusarium infection 30.46 10.89 27 109268 970 29464262
Hepatic cancer recurrent 30.42 10.89 17 109278 285 29464947
Respiratory tract infection fungal 30.41 10.89 23 109272 658 29464574
Renal arteriosclerosis 30.36 10.89 13 109282 117 29465115
Brain abscess 30.35 10.89 43 109252 2612 29462620
Systemic candida 30.28 10.89 44 109251 2736 29462496
Aplasia 30.14 10.89 54 109241 4009 29461223
Human polyomavirus infection 30.11 10.89 23 109272 668 29464564
Cytomegalovirus hepatitis 30.10 10.89 17 109278 291 29464941
Bronchiolitis obliterans syndrome 30.08 10.89 14 109281 156 29465076
Behcet's syndrome 29.96 10.89 8 109287 11 29465221
Chronic graft versus host disease in eye 29.90 10.89 10 109285 41 29465191
Cutaneous sporotrichosis 29.83 10.89 9 109286 24 29465208
Dysgeusia 29.80 10.89 24 109271 22650 29442582
Orthostatic hypotension 29.68 10.89 24 109271 22605 29442627
Renal vessel disorder 29.67 10.89 15 109280 203 29465029
Adverse drug reaction 29.65 10.89 27 109268 23993 29441239
Autoimmune haemolytic anaemia 29.65 10.89 52 109243 3796 29461436
Hypocalcaemia 29.59 10.89 20 109275 20645 29444587
Mass excision 29.57 10.89 9 109286 25 29465207
Leukopenia 29.49 10.89 323 108972 54880 29410352
Encephalitis viral 29.42 10.89 28 109267 1104 29464128
Klebsiella infection 29.38 10.89 76 109219 7273 29457959
Growth retardation 29.05 10.89 33 109262 1603 29463629
Unresponsive to stimuli 28.98 10.89 30 109265 25096 29440136
Skin papilloma 28.91 10.89 34 109261 1715 29463517
Heart rate increased 28.89 10.89 63 109232 38875 29426357
Chimerism 28.85 10.89 15 109280 216 29465016
Toxic leukoencephalopathy 28.80 10.89 16 109279 265 29464967
Pneumonia pseudomonal 28.75 10.89 47 109248 3240 29461992
Complications of transplanted liver 28.73 10.89 15 109280 218 29465014
Papilloma viral infection 28.64 10.89 19 109276 439 29464793
Removal of renal transplant 28.58 10.89 9 109286 29 29465203
Respiratory arrest 28.51 10.89 32 109263 25801 29439431
Central nervous system fungal infection 28.49 10.89 17 109278 324 29464908
Infection reactivation 28.46 10.89 27 109268 1060 29464172
Foetal exposure during pregnancy 28.40 10.89 51 109244 33816 29431416
Anaemia 28.26 10.89 548 108747 200403 29264829
Glomerulonephritis membranoproliferative 28.23 10.89 18 109277 388 29464844
Prostatic specific antigen increased 28.16 10.89 6 109289 12558 29452674
Opportunistic infection 28.10 10.89 31 109264 1458 29463774
General physical health deterioration 28.03 10.89 244 109051 102613 29362619
Mycobacterium kansasii infection 27.96 10.89 15 109280 231 29465001
Acinetobacter infection 27.94 10.89 26 109269 996 29464236
Stress 27.93 10.89 23 109272 21467 29443765
Intentional self-injury 27.83 10.89 6 109289 12455 29452777
Diffuse alveolar damage 27.78 10.89 36 109259 2007 29463225
Anuria 27.76 10.89 88 109207 9453 29455779
Thrombosis 27.72 10.89 75 109220 42970 29422262
Porokeratosis 27.70 10.89 11 109284 80 29465152
Lepromatous leprosy 27.68 10.89 10 109285 54 29465178
Drug ineffective for unapproved indication 27.66 10.89 115 109180 14099 29451133
Respiratory syncytial virus infection 27.62 10.89 49 109246 3610 29461622
Erythema infectiosum 27.54 10.89 13 109282 150 29465082
Lymphopenia 27.53 10.89 111 109184 13422 29451810
B-cell lymphoma 27.37 10.89 50 109245 3768 29461464
Philadelphia positive chronic myeloid leukaemia 27.36 10.89 11 109284 83 29465149
Poikiloderma 26.94 10.89 13 109282 158 29465074
Papilloma 26.92 10.89 12 109283 120 29465112
Serum ferritin increased 26.82 10.89 62 109233 5526 29459706
Plasmacytoma 26.81 10.89 45 109250 3170 29462062
Septic shock 26.81 10.89 351 108944 62209 29403023
Hydronephrosis 26.77 10.89 82 109213 8648 29456584
Incorrect route of product administration 26.72 10.89 4 109291 10797 29454435
Pyelonephritis chronic 26.70 10.89 9 109286 38 29465194
Hepatitis B reactivation 26.67 10.89 45 109250 3184 29462048
Dyskinesia 26.66 10.89 21 109274 20040 29445192
Trichophytosis 26.45 10.89 15 109280 259 29464973
Aplastic anaemia 26.34 10.89 74 109221 7436 29457796
Oxygen saturation decreased 26.24 10.89 82 109213 44855 29420377
Osmotic demyelination syndrome 26.21 10.89 21 109274 655 29464577
Escherichia sepsis 26.17 10.89 50 109245 3899 29461333
Abdominal pain upper 26.17 10.89 126 109169 60867 29404365
Incisional drainage 26.08 10.89 11 109284 95 29465137
Hypercholesterolaemia 26.05 10.89 72 109223 7166 29458066
Pneumonia aspiration 25.99 10.89 61 109234 36676 29428556
Adverse event 25.92 10.89 12 109283 15279 29449953
Contusion 25.92 10.89 47 109248 31048 29434184
Candida sepsis 25.86 10.89 26 109269 1097 29464135
Bone marrow failure 25.86 10.89 182 109113 27267 29437965
Corneal endotheliitis 25.83 10.89 8 109287 24 29465208
Blindness cortical 25.75 10.89 16 109279 329 29464903
Hypertensive encephalopathy 25.58 10.89 16 109279 333 29464899
Sweat gland tumour 25.54 10.89 17 109278 395 29464837
Laboratory test abnormal 25.50 10.89 18 109277 18167 29447065
Transient ischaemic attack 25.49 10.89 29 109266 23241 29441991
Cytomegalovirus gastrointestinal infection 25.45 10.89 13 109282 180 29465052
Skin laceration 25.38 10.89 5 109290 11057 29454175
Sleep apnoea syndrome 25.24 10.89 17 109278 17582 29447650
Alanine aminotransferase increased 25.17 10.89 385 108910 70559 29394673
Sporotrichosis 25.16 10.89 9 109286 47 29465185
Blood pressure decreased 25.15 10.89 85 109210 45392 29419840
Lung lobectomy 25.13 10.89 8 109287 27 29465205
Bowen's disease 25.08 10.89 12 109283 143 29465089
Blood pressure fluctuation 24.99 10.89 22 109273 19872 29445360
Tumour lysis syndrome 24.96 10.89 10 109285 13874 29451358
Fungal sepsis 24.90 10.89 22 109273 787 29464445
Bone marrow transplant rejection 24.89 10.89 13 109282 189 29465043
Nephropathy 24.83 10.89 58 109237 5205 29460027
Cytomegalovirus enteritis 24.67 10.89 17 109278 419 29464813
Fungal test positive 24.66 10.89 18 109277 487 29464745
Glomerulonephritis proliferative 24.59 10.89 13 109282 194 29465038
Laser therapy 24.58 10.89 6 109289 4 29465228
Pneumonia adenoviral 24.57 10.89 12 109283 150 29465082
Enterococcal sepsis 24.50 10.89 29 109266 1473 29463759
Ventricular fibrillation 24.50 10.89 14 109281 15819 29449413
Heart rate irregular 24.33 10.89 9 109286 13108 29452124
Synovitis 24.32 10.89 92 109203 10798 29454434
Macule 24.28 10.89 24 109271 992 29464240
Hepatitis B 24.23 10.89 59 109236 5438 29459794
Blood potassium decreased 24.22 10.89 14 109281 15720 29449512
Phototherapy 24.08 10.89 8 109287 32 29465200
Papule 24.06 10.89 43 109252 3186 29462046
Tremor 23.99 10.89 166 109129 73372 29391860
Disseminated toxoplasmosis 23.88 10.89 8 109287 33 29465199
Road traffic accident 23.74 10.89 14 109281 15547 29449685
Coma 23.73 10.89 71 109224 39379 29425853
Pneumocystis jirovecii infection 23.69 10.89 28 109267 1420 29463812
Hyperkeratosis 23.68 10.89 43 109252 3226 29462006
Neuroendocrine carcinoma of the skin 23.48 10.89 19 109276 601 29464631
Infective tenosynovitis 23.46 10.89 9 109286 59 29465173
Klebsiella sepsis 23.41 10.89 30 109265 1654 29463578
Enterobacter infection 23.34 10.89 33 109262 2001 29463231
Angina pectoris 23.29 10.89 42 109253 27808 29437424
Sinus bradycardia 23.20 10.89 7 109288 11596 29453636
C-reactive protein increased 23.18 10.89 258 109037 44005 29421227
Cat scratch disease 23.16 10.89 10 109285 92 29465140
Post transplant distal limb syndrome 23.14 10.89 14 109281 274 29464958
Phaeohyphomycosis 23.13 10.89 21 109274 779 29464453
Drug level fluctuating 22.98 10.89 17 109278 470 29464762
Leukoencephalopathy 22.91 10.89 46 109249 3721 29461511
CSF protein increased 22.88 10.89 20 109275 705 29464527
Complications of transplanted lung 22.77 10.89 12 109283 178 29465054
West Nile viral infection 22.70 10.89 19 109276 631 29464601
Debridement 22.68 10.89 21 109274 799 29464433
Treatment noncompliance 22.63 10.89 34 109261 24193 29441039
Nightmare 22.62 10.89 7 109288 11410 29453822
Oesophageal squamous cell carcinoma 22.59 10.89 15 109280 347 29464885
Hepatic fibrosis 22.58 10.89 42 109253 3210 29462022
Respiratory failure 22.47 10.89 493 108802 96638 29368594
Bronchitis 22.43 10.89 66 109229 36802 29428430
Epstein-Barr virus test positive 22.40 10.89 17 109278 489 29464743
Lethargy 22.34 10.89 68 109227 37512 29427720
Neoplasm skin 22.20 10.89 18 109277 571 29464661
Ureaplasma infection 22.13 10.89 12 109283 189 29465043
Hepatotoxicity 22.12 10.89 127 109168 17740 29447492
Dysphagia 22.11 10.89 116 109179 54810 29410422
Vertigo 22.09 10.89 29 109266 21832 29443400
Acute lymphocytic leukaemia recurrent 22.04 10.89 36 109259 2480 29462752
Human ehrlichiosis 22.02 10.89 12 109283 191 29465041
Product quality issue 21.94 10.89 16 109279 15879 29449353
Haemorrhagic cyst 21.93 10.89 9 109286 72 29465160
Cough 21.85 10.89 333 108962 126394 29338838
Oligospermia 21.82 10.89 9 109286 73 29465159
Irritability 21.76 10.89 30 109265 22122 29443110
Flatulence 21.75 10.89 20 109275 17689 29447543
Acute disseminated encephalomyelitis 21.72 10.89 9 109286 74 29465158
Mycobacterium chelonae infection 21.70 10.89 18 109277 590 29464642
Injury 21.67 10.89 23 109272 19023 29446209
Blood immunoglobulin G decreased 21.65 10.89 24 109271 1135 29464097
Swelling face 21.60 10.89 26 109269 20324 29444908
Infection in an immunocompromised host 21.60 10.89 18 109277 594 29464638
Pain in jaw 21.57 10.89 8 109287 11633 29453599
Infection 21.55 10.89 401 108894 76350 29388882
Paraesthesia 21.52 10.89 114 109181 53731 29411501
Atypical mycobacterial infection 21.45 10.89 19 109276 682 29464550
White blood cell count decreased 21.29 10.89 201 109094 83161 29382071
Skin necrosis 21.25 10.89 53 109242 4959 29460273
Reticulocytosis 21.24 10.89 13 109282 260 29464972
Presyncope 21.18 10.89 17 109278 16072 29449160
Dystonia 21.16 10.89 5 109290 9744 29455488
Aspartate aminotransferase increased 21.14 10.89 324 108971 59401 29405831
NPM1 gene mutation 21.14 10.89 10 109285 116 29465116
Pathogen resistance 21.05 10.89 72 109223 8044 29457188
Small intestinal obstruction 21.01 10.89 11 109284 13050 29452182
Anger 21.01 10.89 7 109288 10883 29454349
Perinephric collection 21.00 10.89 11 109284 161 29465071
Wound dehiscence 20.99 10.89 39 109256 2978 29462254
Hepatosplenomegaly 20.96 10.89 44 109251 3673 29461559
Pulmonary tuberculosis 20.85 10.89 48 109247 4267 29460965
Cytogenetic abnormality 20.79 10.89 20 109275 799 29464433
Microsporidia infection 20.79 10.89 17 109278 546 29464686
Abdominal distension 20.78 10.89 93 109202 45818 29419414
Anaplastic large cell lymphoma T- and null-cell types 20.73 10.89 9 109286 84 29465148
Subdural haematoma 20.67 10.89 22 109273 18171 29447061
Acanthamoeba infection 20.64 10.89 15 109280 403 29464829
Lip swelling 20.64 10.89 10 109285 12400 29452832
Retinitis 20.52 10.89 13 109282 277 29464955
CSF cell count increased 20.50 10.89 7 109288 31 29465201
Epistaxis 20.47 10.89 286 109009 51418 29413814
Biliary hamartoma 20.45 10.89 6 109289 14 29465218
Neurological symptom 20.31 10.89 41 109254 3329 29461903
Accidental overdose 20.29 10.89 21 109274 17572 29447660
Diffuse large B-cell lymphoma stage IV 20.24 10.89 12 109283 226 29465006
Swollen tongue 20.22 10.89 10 109285 12256 29452976
Cerebral fungal infection 20.15 10.89 12 109283 228 29465004
Tendonitis 20.10 10.89 70 109225 7891 29457341
Haematoma evacuation 20.08 10.89 11 109284 177 29465055
Disturbance in attention 20.07 10.89 30 109265 21394 29443838
Idiopathic intracranial hypertension 19.97 10.89 17 109278 578 29464654
Bile duct stenosis 19.93 10.89 23 109272 1137 29464095
IgA nephropathy 19.92 10.89 22 109273 1036 29464196
Citrobacter infection 19.90 10.89 15 109280 427 29464805
Dysphonia 19.88 10.89 25 109270 19171 29446061
Cancer surgery 19.83 10.89 15 109280 429 29464803
Gastrointestinal haemorrhage 19.79 10.89 193 109102 79340 29385892
Musculoskeletal pain 19.75 10.89 49 109246 28904 29436328
Cholangitis 19.67 10.89 67 109228 7470 29457762
Disseminated cryptococcosis 19.64 10.89 23 109272 1155 29464077
Scleral hyperaemia 19.60 10.89 8 109287 63 29465169
Gastroenteritis rotavirus 19.60 10.89 11 109284 186 29465046
Lung abscess 19.58 10.89 33 109262 2333 29462899
Hepatic enzyme increased 19.56 10.89 201 109094 33598 29431634
Drug level decreased 19.45 10.89 59 109236 6188 29459044
Microangiopathy 19.45 10.89 19 109276 774 29464458
Therapy cessation 19.39 10.89 15 109280 14447 29450785
Squamous cell carcinoma of the tongue 19.26 10.89 12 109283 248 29464984
Hot flush 19.22 10.89 16 109279 14854 29450378
Endotracheal intubation 19.19 10.89 35 109260 2634 29462598
Haematochezia 19.19 10.89 71 109224 36912 29428320
Arterial disorder 19.17 10.89 22 109273 1081 29464151
Hair follicle tumour benign 19.10 10.89 5 109290 6 29465226
Cryptococcal cutaneous infection 19.08 10.89 8 109287 68 29465164
Necrosis 19.07 10.89 51 109244 4979 29460253
Nephrosclerosis 19.03 10.89 19 109276 795 29464437
Parvovirus B19 infection 18.99 10.89 18 109277 706 29464526
Adenomatous polyposis coli 18.93 10.89 10 109285 149 29465083
Restlessness 18.88 10.89 33 109262 22112 29443120
Mitral valve incompetence 18.85 10.89 13 109282 13280 29451952
Nephrolithiasis 18.78 10.89 41 109254 25293 29439939
Haematotoxicity 18.77 10.89 61 109234 6638 29458594
Toxic encephalopathy 18.75 10.89 48 109247 4564 29460668
Varicella 18.69 10.89 25 109270 1438 29463794
Neutrophil count decreased 18.68 10.89 90 109205 43477 29421755
Splenic abscess 18.67 10.89 13 109282 326 29464906
Varicella zoster virus infection 18.62 10.89 25 109270 1443 29463789
Osteoporosis 18.56 10.89 84 109211 10685 29454547
Full blood count decreased 18.55 10.89 19 109276 15973 29449259
Sinus tachycardia 18.52 10.89 17 109278 15052 29450180
Fear 18.52 10.89 6 109289 9498 29455734
Sleep disorder 18.47 10.89 39 109256 24347 29440885
Umbilical hernia repair 18.47 10.89 6 109289 22 29465210
Undifferentiated sarcoma 18.42 10.89 4 109291 0 29465232
Interleukin-2 receptor increased 18.40 10.89 9 109286 113 29465119
Skin neoplasm excision 18.39 10.89 13 109282 334 29464898
Cytokine release syndrome 18.38 10.89 13 109282 13106 29452126
Red blood cell abnormality 18.29 10.89 12 109283 272 29464960
Oral herpes 18.25 10.89 47 109248 4485 29460747
Graft complication 18.23 10.89 13 109282 339 29464893
Pallor 18.22 10.89 31 109264 20993 29444239
Central nervous system lesion 18.21 10.89 54 109241 5594 29459638
Acanthosis 18.19 10.89 9 109286 116 29465116
Refractoriness to platelet transfusion 18.10 10.89 7 109288 47 29465185
Mycobacterium marinum infection 18.02 10.89 12 109283 279 29464953
Limb deformity 18.00 10.89 15 109280 495 29464737
Organising pneumonia 17.95 10.89 50 109245 4998 29460234
Product container issue 17.91 10.89 16 109279 581 29464651
Stent removal 17.91 10.89 5 109290 9 29465223
Disseminated Bacillus Calmette-Guerin infection 17.87 10.89 10 109285 168 29465064
Abscess drainage 17.84 10.89 11 109284 223 29465009
Ureteric dilatation 17.72 10.89 9 109286 123 29465109
Meningococcal sepsis 17.68 10.89 6 109289 26 29465206
Arthropathy 17.59 10.89 33 109262 21521 29443711
Feeling cold 17.57 10.89 6 109289 9185 29456047
Nodule 17.56 10.89 50 109245 5062 29460170
Troponin increased 17.54 10.89 6 109289 9177 29456055
Gouty tophus 17.53 10.89 9 109286 126 29465106
Fungaemia 17.49 10.89 30 109265 2151 29463081
Uveitis 17.44 10.89 55 109240 5892 29459340
Ischaemic stroke 17.40 10.89 20 109275 15957 29449275
Mycobacterium abscessus infection 17.38 10.89 14 109281 440 29464792
Panniculitis 17.37 10.89 22 109273 1199 29464033
Haematemesis 17.33 10.89 41 109254 24585 29440647
Rib fracture 17.30 10.89 13 109282 12705 29452527
Device malfunction 17.25 10.89 5 109290 8502 29456730
Malabsorption 17.23 10.89 28 109267 1920 29463312
Full blood count abnormal 17.23 10.89 18 109277 14995 29450237
Tongue ulceration 17.14 10.89 21 109274 1106 29464126
Off label use 17.08 10.89 1311 107984 299489 29165743
Cardiac failure 17.06 10.89 199 109096 79088 29386144
Herpes zoster 17.05 10.89 178 109117 29874 29435358
Oral disorder 17.03 10.89 41 109254 3752 29461480
Influenza like illness 17.01 10.89 41 109254 24429 29440803
Urinoma 16.98 10.89 10 109285 186 29465046
Arteriosclerosis coronary artery 16.96 10.89 9 109286 10596 29454636
Dysarthria 16.94 10.89 58 109237 30853 29434379
Rhinovirus infection 16.91 10.89 37 109258 3179 29462053
Hippocampal sclerosis 16.82 10.89 8 109287 94 29465138
Pityriasis rubra pilaris 16.74 10.89 7 109288 59 29465173
Ureteritis 16.67 10.89 5 109290 13 29465219
Meningeal neoplasm 16.64 10.89 7 109288 60 29465172
Upper gastrointestinal haemorrhage 16.63 10.89 35 109260 21879 29443353
Ophthalmic herpes simplex 16.55 10.89 11 109284 255 29464977
Thoracotomy 16.54 10.89 7 109288 61 29465171
Pulmonary haemorrhage 16.49 10.89 73 109222 9197 29456035
Glomerulonephritis minimal lesion 16.49 10.89 13 109282 396 29464836
Post procedural urine leak 16.47 10.89 9 109286 144 29465088
Depressed mood 16.43 10.89 22 109273 16426 29448806
Botryomycosis 16.37 10.89 6 109289 34 29465198
Osteoarthritis 16.34 10.89 26 109269 18077 29447155
Intra-aortic balloon placement 16.19 10.89 4 109291 3 29465229
Skin cancer metastatic 16.19 10.89 4 109291 3 29465229
Urethral dilatation 16.19 10.89 4 109291 3 29465229
Cholangitis chronic 16.19 10.89 4 109291 3 29465229
Hodgkin's disease mixed cellularity stage unspecified 16.19 10.89 4 109291 3 29465229
Intestinal obstruction 16.18 10.89 29 109266 19248 29445984
Vascular graft complication 16.18 10.89 8 109287 103 29465129
Extrapyramidal disorder 16.16 10.89 10 109285 10821 29454411
Papilloedema 16.15 10.89 30 109265 2290 29462942
Angioedema 16.09 10.89 62 109233 31853 29433379
Musculoskeletal chest pain 15.96 10.89 6 109289 8654 29456578
Palatal ulcer 15.95 10.89 6 109289 37 29465195
Keratitis 15.93 10.89 21 109274 1191 29464041
Dermatitis atopic 15.83 10.89 29 109266 2190 29463042
Gammopathy 15.79 10.89 7 109288 69 29465163
Peripheral T-cell lymphoma unspecified 15.78 10.89 13 109282 422 29464810
Salivary hypersecretion 15.69 10.89 4 109291 7405 29457827
Pseudomonal sepsis 15.64 10.89 34 109261 2908 29462324
Productive cough 15.58 10.89 61 109234 31198 29434034
Pollakiuria 15.55 10.89 24 109271 16892 29448340
Pneumonia bacterial 15.45 10.89 72 109223 9271 29455961
Upper respiratory tract inflammation 15.31 10.89 24 109271 1596 29463636
Gastroenteritis cryptosporidial 15.30 10.89 9 109286 167 29465065
Colectomy 15.24 10.89 23 109272 1480 29463752
Ageusia 15.17 10.89 7 109288 8931 29456301
Iron overload 15.16 10.89 20 109275 1135 29464097
Therapy interrupted 15.14 10.89 6 109289 8380 29456852
Disorientation 15.10 10.89 57 109238 29458 29435774
Trichosporon infection 15.07 10.89 15 109280 625 29464607
Ureteric anastomosis complication 15.07 10.89 6 109289 44 29465188
Ureteric obstruction 15.05 10.89 20 109275 1143 29464089
Subacute sclerosing panencephalitis 15.05 10.89 5 109290 20 29465212
CSF pressure increased 15.05 10.89 5 109290 20 29465212
Pyelonephritis 15.01 10.89 49 109246 5344 29459888
Device issue 15.01 10.89 5 109290 7775 29457457
Red blood cell sedimentation rate 14.96 10.89 14 109281 540 29464692
Metabolic acidosis 14.90 10.89 80 109215 37582 29427650
Liver abscess 14.90 10.89 36 109259 3302 29461930
Hemianopia 14.82 10.89 15 109280 638 29464594
Tuberculoma of central nervous system 14.82 10.89 10 109285 238 29464994
Sinusitis bacterial 14.81 10.89 11 109284 306 29464926
Cutaneous T-cell lymphoma stage I 14.77 10.89 4 109291 6 29465226
Laryngopharyngitis 14.77 10.89 4 109291 6 29465226
Subcapsular renal haematoma 14.77 10.89 12 109283 382 29464850
Abdominal hernia repair 14.73 10.89 6 109289 47 29465185
Disseminated varicella zoster vaccine virus infection 14.73 10.89 6 109289 47 29465185
Appendicitis 14.71 10.89 7 109288 8772 29456460
Spindle cell sarcoma 14.70 10.89 8 109287 127 29465105
Throat tightness 14.69 10.89 4 109291 7087 29458145
Keratoacanthoma 14.69 10.89 14 109281 553 29464679
Self-consciousness 14.67 10.89 5 109290 22 29465210
Viral myocarditis 14.64 10.89 8 109287 128 29465104
Prostate cancer 14.60 10.89 47 109248 25480 29439752
Pneumonia klebsiella 14.56 10.89 31 109264 2613 29462619
Urinary incontinence 14.56 10.89 24 109271 16457 29448775
Injection site reaction 14.51 10.89 12 109283 11176 29454056
Enterobacter bacteraemia 14.47 10.89 11 109284 317 29464915
Blood pressure systolic increased 14.45 10.89 25 109270 16820 29448412
Malignant melanoma stage I 14.44 10.89 7 109288 86 29465146
Product administration error 14.44 10.89 19 109276 14291 29450941
Myasthenic syndrome 14.43 10.89 12 109283 395 29464837
Nerve conduction studies abnormal 14.41 10.89 6 109289 50 29465182
Coinfection 14.40 10.89 4 109291 7 29465225
Nasopharyngeal cancer 14.37 10.89 8 109287 133 29465099
Malignant fibrous histiocytoma 14.37 10.89 7 109288 87 29465145
Lower respiratory tract infection 14.33 10.89 50 109245 26452 29438780
Explorative laparotomy 14.32 10.89 5 109290 24 29465208
Bronchopneumopathy 14.30 10.89 12 109283 400 29464832
Stenotrophomonas infection 14.28 10.89 24 109271 1693 29463539
Anaphylactic reaction 14.26 10.89 53 109242 27520 29437712
Infertility 14.24 10.89 9 109286 191 29465041
Incorrect dose administered 14.22 10.89 68 109227 32916 29432316
Autoinflammatory disease 14.21 10.89 6 109289 52 29465180
Cryptosporidiosis infection 14.17 10.89 12 109283 405 29464827
Ventricular extrasystoles 14.16 10.89 11 109284 10571 29454661
Bronchoalveolar lavage 14.16 10.89 5 109290 25 29465207
Nephrostomy 14.07 10.89 9 109286 195 29465037
Dry mouth 13.99 10.89 38 109257 21746 29443486
Sudden death 13.97 10.89 19 109276 14091 29451141
Urinary tract infection enterococcal 13.93 10.89 16 109279 787 29464445
Mental status changes 13.92 10.89 74 109221 34853 29430379
Hip fracture 13.92 10.89 11 109284 10481 29454751
Biliary catheter insertion 13.92 10.89 6 109289 55 29465177
Non-Hodgkin's lymphoma 13.90 10.89 22 109273 1475 29463757
Nephrogenic diabetes insipidus 13.85 10.89 19 109276 1120 29464112
Superficial injury of eye 13.84 10.89 5 109290 27 29465205
Viral infection 13.83 10.89 98 109197 14712 29450520
Liver operation 13.81 10.89 3 109292 0 29465232
Renal cell carcinoma stage II 13.81 10.89 3 109292 0 29465232
Gingivectomy 13.81 10.89 3 109292 0 29465232
Ureteral stent removal 13.81 10.89 3 109292 0 29465232
Primary mediastinal large B-cell lymphoma 13.81 10.89 3 109292 0 29465232
Ureteric repair 13.81 10.89 3 109292 0 29465232
Bence Jones protein urine present 13.81 10.89 3 109292 0 29465232
Bacterial abdominal infection 13.81 10.89 3 109292 0 29465232
Acute graft versus host disease oral 13.81 10.89 3 109292 0 29465232
Transplant abscess 13.81 10.89 3 109292 0 29465232
Hepatitis B e antigen 13.81 10.89 3 109292 0 29465232
Cyst drainage 13.81 10.89 3 109292 0 29465232
Growth disorder 13.81 10.89 3 109292 0 29465232
Peripheral artery dissection 13.81 10.89 3 109292 0 29465232
Hepatitis viral 13.80 10.89 13 109282 506 29464726
Pseudomembranous colitis 13.79 10.89 30 109265 2567 29462665
Cytomegalovirus enterocolitis 13.77 10.89 16 109279 797 29464435
Rotavirus infection 13.76 10.89 11 109284 342 29464890
Biliary ischaemia 13.74 10.89 4 109291 9 29465223
Neurological decompensation 13.72 10.89 29 109266 2433 29462799
Chest expansion decreased 13.67 10.89 8 109287 147 29465085
Retinal scar 13.59 10.89 10 109285 274 29464958
Generalised oedema 13.58 10.89 79 109216 11086 29454146
Supraventricular tachycardia 13.58 10.89 10 109285 9874 29455358
Osteonecrosis 13.53 10.89 91 109204 13428 29451804
Cyanosis 13.51 10.89 13 109282 11254 29453978
Product use issue 13.48 10.89 266 109029 51178 29414054
Benign prostatic hyperplasia 13.48 10.89 14 109281 11696 29453536
Renal tubular disorder 13.45 10.89 41 109254 4311 29460921
Device related sepsis 13.45 10.89 29 109266 2466 29462766
Fungal endocarditis 13.44 10.89 10 109285 279 29464953
Diarrhoea haemorrhagic 13.43 10.89 50 109245 5824 29459408
Viral uveitis 13.40 10.89 5 109290 30 29465202
Eye discharge 13.37 10.89 23 109272 1653 29463579
Dry skin 13.27 10.89 43 109252 23264 29441968
Urinary tract infection viral 13.27 10.89 5 109290 31 29465201
Osteoma 13.27 10.89 5 109290 31 29465201
Limbic encephalitis 13.25 10.89 11 109284 361 29464871
Oedema peripheral 13.15 10.89 287 109008 103270 29361962
Retinopathy haemorrhagic 13.13 10.89 5 109290 32 29465200
Neuroendocrine tumour of the lung metastatic 13.04 10.89 7 109288 108 29465124
Granulomatous dermatitis 13.02 10.89 9 109286 223 29465009
Psoriasis area severity index increased 13.00 10.89 5 109290 33 29465199
Coombs direct test positive 12.96 10.89 10 109285 295 29464937
Bronchitis bacterial 12.94 10.89 14 109281 644 29464588
Herpes zoster cutaneous disseminated 12.94 10.89 8 109287 163 29465069
Oral papilloma 12.92 10.89 4 109291 12 29465220
Ureteral stent insertion 12.88 10.89 6 109289 67 29465165
Epstein-Barr virus antigen positive 12.88 10.89 5 109290 34 29465198
Anogenital warts 12.86 10.89 13 109282 552 29464680
Renal hypertension 12.85 10.89 8 109287 165 29465067
Superficial spreading melanoma stage unspecified 12.81 10.89 8 109287 166 29465066
Skin erosion 12.78 10.89 23 109272 1713 29463519
Concomitant disease aggravated 12.77 10.89 44 109251 4934 29460298
Marrow hyperplasia 12.76 10.89 17 109278 974 29464258
T-cell prolymphocytic leukaemia 12.75 10.89 5 109290 35 29465197
Anti-platelet antibody positive 12.74 10.89 9 109286 231 29465001
Pulmonary alveolar haemorrhage 12.71 10.89 52 109243 6328 29458904
Renal cell carcinoma stage III 12.68 10.89 4 109291 13 29465219
Splenic artery aneurysm 12.68 10.89 4 109291 13 29465219
Passenger lymphocyte syndrome 12.63 10.89 5 109290 36 29465196
Papillary cystadenoma lymphomatosum 12.63 10.89 5 109290 36 29465196
Disseminated intravascular coagulation 12.61 10.89 121 109174 19859 29445373
Neck pain 12.61 10.89 39 109256 21408 29443824
Lung neoplasm 12.60 10.89 40 109255 4300 29460932
Pericardial drainage 12.58 10.89 6 109289 71 29465161
Eccrine squamous syringometaplasia 12.52 10.89 5 109290 37 29465195
Bile duct stent insertion 12.50 10.89 6 109289 72 29465160
Enamel anomaly 12.49 10.89 7 109288 118 29465114
Aneurysm 12.48 10.89 22 109273 1612 29463620
Trichodysplasia spinulosa 12.44 10.89 9 109286 240 29464992
Tooth hypoplasia 12.44 10.89 7 109288 119 29465113
Ureteral necrosis 12.40 10.89 5 109290 38 29465194
Lactobacillus infection 12.39 10.89 7 109288 120 29465112
Bone marrow oedema 12.36 10.89 12 109283 485 29464747
Tonsillar hypertrophy 12.34 10.89 13 109282 580 29464652
Complement factor C3 decreased 12.29 10.89 5 109290 39 29465193
Karyotype analysis abnormal 12.29 10.89 5 109290 39 29465193
Therapeutic procedure 12.28 10.89 8 109287 179 29465053
Computerised tomogram abnormal 12.26 10.89 22 109273 1635 29463597
Haemorrhoids 12.26 10.89 15 109280 11642 29453590
Lymphoma 12.25 10.89 70 109225 9758 29455474
Metastases to nasal sinuses 12.24 10.89 4 109291 15 29465217
Urinary bladder haematoma 12.24 10.89 4 109291 15 29465217
Hypospermia 12.24 10.89 4 109291 15 29465217
Hypophagia 12.24 10.89 38 109257 20834 29444398
Surgery 12.22 10.89 80 109215 11699 29453533
Aeromonas infection 12.19 10.89 9 109286 248 29464984
Limb injury 12.17 10.89 10 109285 9345 29455887
Ulcer 12.15 10.89 55 109240 6996 29458236
Sebaceous carcinoma 12.15 10.89 6 109289 77 29465155
Clonal evolution 12.13 10.89 7 109288 125 29465107
Arrhythmia 12.12 10.89 67 109228 31246 29433986
Skin toxicity 12.10 10.89 36 109259 3735 29461497
Glomerulonephritis rapidly progressive 12.08 10.89 12 109283 499 29464733
Cold sweat 12.07 10.89 9 109286 8833 29456399
Faciobrachial dystonic seizure 12.04 10.89 4 109291 16 29465216
Impaired work ability 12.03 10.89 3 109292 5637 29459595
Atrial septal defect 12.03 10.89 5 109290 6784 29458448
Lesion excision 11.97 10.89 5 109290 42 29465190
Ophthalmic vein thrombosis 11.97 10.89 5 109290 42 29465190
Blood parathyroid hormone decreased 11.96 10.89 15 109280 809 29464423
Bone marrow transplant 11.91 10.89 16 109279 924 29464308
Skin hypertrophy 11.91 10.89 27 109268 2376 29462856
Prescribed underdose 11.88 10.89 7 109288 7779 29457453
Glomerular vascular disorder 11.88 10.89 6 109289 81 29465151
Cytomegalovirus test 11.87 10.89 5 109290 43 29465189
Activated partial thromboplastin time shortened 11.85 10.89 11 109284 420 29464812
Sebaceous adenoma 11.85 10.89 4 109291 17 29465215
Malacoplakia 11.85 10.89 7 109288 131 29465101
Renal aneurysm 11.85 10.89 7 109288 131 29465101
Pseudolymphoma 11.77 10.89 12 109283 515 29464717
Macrophage activation 11.75 10.89 3 109292 3 29465229
Transfusion associated graft versus host disease 11.75 10.89 3 109292 3 29465229
Hepatobiliary cancer 11.75 10.89 3 109292 3 29465229
Pseudallescheria infection 11.75 10.89 3 109292 3 29465229
Leiomyoma 11.75 10.89 3 109292 3 29465229
Renal arteritis 11.75 10.89 3 109292 3 29465229
Hepatitis B surface antigen positive 11.71 10.89 7 109288 134 29465098
Gynaecomastia 11.70 10.89 8 109287 8209 29457023
Vitamin D deficiency 11.68 10.89 3 109292 5526 29459706
Total cholesterol/HDL ratio decreased 11.68 10.89 5 109290 45 29465187
Semen volume decreased 11.67 10.89 10 109285 343 29464889
Lymphangitis 11.65 10.89 12 109283 521 29464711
Pneumonia influenzal 11.61 10.89 19 109276 1311 29463921
Human anaplasmosis 11.58 10.89 5 109290 46 29465186
Tuberculosis 11.56 10.89 55 109240 7141 29458091
Dermatitis acneiform 11.56 10.89 3 109292 5488 29459744
Rash pruritic 11.56 10.89 43 109252 22320 29442912
Iris neoplasm 11.49 10.89 4 109291 19 29465213
Viral myositis 11.49 10.89 4 109291 19 29465213
Bronchioloalveolar carcinoma 11.49 10.89 4 109291 19 29465213
Hypereosinophilic syndrome 11.47 10.89 8 109287 201 29465031
Granuloma 11.45 10.89 27 109268 2437 29462795
Pneumonia herpes viral 11.44 10.89 6 109289 88 29465144
VIth nerve paralysis 11.43 10.89 14 109281 737 29464495
Visual acuity reduced 11.41 10.89 94 109201 14782 29450450
Angina unstable 11.41 10.89 14 109281 10851 29454381
Granuloma skin 11.39 10.89 13 109282 635 29464597
Melaena 11.37 10.89 68 109227 31108 29434124
Transaminases increased 11.37 10.89 131 109164 22531 29442701
Hyperfibrinogenaemia 11.31 10.89 5 109290 49 29465183
Herpes ophthalmic 11.30 10.89 11 109284 446 29464786
Peripheral nerve palsy 11.29 10.89 3 109292 4 29465228
Parenteral nutrition 11.29 10.89 3 109292 4 29465228
Gastrointestinal fungal infection 11.21 10.89 6 109289 92 29465140
Arterial rupture 11.14 10.89 11 109284 454 29464778
Influenza 11.11 10.89 100 109195 41781 29423451
Gastrointestinal candidiasis 11.05 10.89 7 109288 149 29465083
Pulmonary nocardiosis 11.04 10.89 12 109283 555 29464677
Low turnover osteopathy 11.04 10.89 6 109289 95 29465137
Speech disorder 11.02 10.89 47 109248 23469 29441763
Acquired gene mutation 11.02 10.89 18 109277 1240 29463992
Rectosigmoid cancer 11.01 10.89 7 109288 150 29465082
Cerebrosclerosis 11.01 10.89 4 109291 22 29465210
Steroid dependence 11.01 10.89 9 109286 289 29464943
Bilirubin conjugated abnormal 10.98 10.89 6 109289 96 29465136
Fungal abscess central nervous system 10.98 10.89 6 109289 96 29465136
Renal vein thrombosis 10.97 10.89 7 109288 151 29465081
Pulmonary cavitation 10.97 10.89 14 109281 769 29464463
Tracheostomy 10.94 10.89 13 109282 663 29464569
Renal necrosis 10.93 10.89 7 109288 152 29465080
Gastroenteritis norovirus 10.93 10.89 19 109276 1377 29463855
Hypotony of eye 10.93 10.89 6 109289 97 29465135
Enterococcal bacteraemia 10.89 10.89 20 109275 1513 29463719

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 3115.57 9.81 1764 204835 35435 64256698
Graft versus host disease 2037.30 9.81 959 205640 12854 64279279
Acute graft versus host disease 1776.19 9.81 768 205831 8316 64283817
Product use in unapproved indication 1727.20 9.81 2458 204141 174160 64117973
Transplant rejection 1555.98 9.81 862 205737 16539 64275594
Chronic graft versus host disease 1448.37 9.81 597 206002 5679 64286454
Transplant dysfunction 1436.68 9.81 605 205994 6103 64286030
Acute graft versus host disease in skin 1427.35 9.81 606 205993 6249 64285884
Epstein-Barr virus infection 1231.14 9.81 660 205939 11828 64280305
Post transplant lymphoproliferative disorder 1164.13 9.81 582 206017 8962 64283171
Graft versus host disease in gastrointestinal tract 1004.65 9.81 446 206153 5166 64286967
Kidney transplant rejection 874.41 9.81 480 206119 9031 64283102
Posterior reversible encephalopathy syndrome 871.81 9.81 664 205935 22282 64269851
Graft versus host disease in skin 846.40 9.81 390 206209 4957 64287176
Eye irritation 816.40 9.81 552 206047 15304 64276829
Acute graft versus host disease in intestine 724.66 9.81 311 206288 3298 64288835
Ovarian cyst 698.29 9.81 437 206162 10581 64281552
Completed suicide 671.63 9.81 9 206590 224405 64067728
Cystitis haemorrhagic 653.73 9.81 373 206226 7583 64284550
BK virus infection 621.13 9.81 352 206247 7060 64285073
Thrombotic microangiopathy 582.61 9.81 459 206140 16196 64275937
Nephropathy toxic 555.97 9.81 456 206143 17058 64275075
Renal impairment 544.22 9.81 1281 205318 133736 64158397
Adenovirus infection 529.57 9.81 315 206284 6940 64285193
Epstein-Barr virus associated lymphoproliferative disorder 476.53 9.81 222 206377 2897 64289236
Acne 473.62 9.81 470 206129 22611 64269522
Blood creatinine increased 472.69 9.81 1218 205381 134564 64157569
Cytomegalovirus viraemia 441.58 9.81 327 206272 10501 64281632
Fall 437.28 9.81 415 206184 416411 63875722
Aspergillus infection 437.08 9.81 386 206213 15993 64276140
Bronchopulmonary aspergillosis 431.71 9.81 410 206189 18675 64273458
Fatigue 412.07 9.81 1143 205456 747587 63544546
Multiple organ dysfunction syndrome 407.16 9.81 961 205638 100452 64191681
Acute graft versus host disease in liver 401.16 9.81 164 206435 1523 64290610
Haemophagocytic lymphohistiocytosis 395.84 9.81 377 206222 17232 64274901
Dizziness 382.15 9.81 491 206108 429672 63862461
Cytomegalovirus infection reactivation 379.13 9.81 234 206365 5522 64286611
Complications of transplanted kidney 368.31 9.81 225 206374 5210 64286923
Drug abuse 366.12 9.81 13 206586 132361 64159772
Immunosuppressant drug level increased 364.77 9.81 249 206350 7010 64285123
Chronic graft versus host disease in skin 361.00 9.81 144 206455 1247 64290886
Drug ineffective 348.17 9.81 4160 202439 836087 63456046
Pneumonia cytomegaloviral 326.11 9.81 192 206407 4147 64287986
Hypotension 318.84 9.81 454 206145 380520 63911613
Gingival hypertrophy 318.75 9.81 162 206437 2585 64289548
Liver transplant rejection 316.70 9.81 166 206433 2833 64289300
Drug eruption 307.48 9.81 472 206127 35664 64256469
Blood parathyroid hormone decreased 281.55 9.81 214 206385 7152 64284981
Panniculitis 279.30 9.81 230 206369 8649 64283484
Cytomegalovirus test positive 278.95 9.81 185 206414 4959 64287174
Dyspnoea 277.47 9.81 1273 205326 717401 63574732
Graft versus host disease in liver 267.88 9.81 120 206479 1421 64290712
Basal cell carcinoma 265.46 9.81 405 206194 30433 64261700
Intentional overdose 259.07 9.81 6 206593 89938 64202195
Heart transplant rejection 258.68 9.81 111 206488 1176 64290957
Granuloma skin 253.44 9.81 186 206413 5888 64286245
Obliterative bronchiolitis 249.07 9.81 136 206463 2529 64289604
Nausea 248.93 9.81 1489 205110 784311 63507822
Polyomavirus viraemia 246.08 9.81 104 206495 1058 64291075
Syncope 245.03 9.81 99 206500 157536 64134597
Foreign body sensation in eyes 244.20 9.81 117 206482 1632 64290501
Hepatic function abnormal 241.41 9.81 594 206005 63719 64228414
Chronic allograft nephropathy 240.89 9.81 111 206488 1410 64290723
Mucormycosis 236.86 9.81 193 206406 7148 64284985
Transplant failure 236.65 9.81 149 206450 3645 64288488
Death 230.47 9.81 785 205814 481920 63810213
Constipation 226.71 9.81 240 206359 229097 64063036
Skin necrosis 226.58 9.81 254 206345 14075 64278058
Human herpesvirus 6 infection 225.24 9.81 156 206443 4498 64287635
Asthenia 223.95 9.81 668 205931 427376 63864757
Lymphoproliferative disorder 214.57 9.81 157 206442 4946 64287187
Venoocclusive disease 212.91 9.81 142 206457 3843 64288290
Treatment failure 200.37 9.81 823 205776 115993 64176140
Squamous cell carcinoma 199.31 9.81 234 206365 13635 64278498
Immunosuppressant drug level decreased 198.91 9.81 103 206496 1712 64290421
Pseudomonas infection 195.24 9.81 263 206336 17620 64274513
Proteinuria 194.77 9.81 332 206267 27391 64264742
Chronic graft versus host disease in liver 194.29 9.81 72 206527 499 64291634
Somnolence 191.48 9.81 222 206377 203423 64088710
Polyomavirus-associated nephropathy 191.22 9.81 144 206455 4744 64287389
Complications of bone marrow transplant 190.42 9.81 73 206526 562 64291571
Venoocclusive liver disease 189.08 9.81 195 206404 9820 64282313
Lung transplant rejection 188.69 9.81 90 206509 1242 64290891
Anxiety 186.16 9.81 225 206374 202424 64089709
Vomiting 185.52 9.81 1023 205576 550094 63742039
Pain 184.93 9.81 1030 205569 552481 63739652
Dehydration 179.40 9.81 260 206339 216503 64075630
Disease recurrence 178.89 9.81 344 206255 31166 64260967
Eye pain 178.00 9.81 344 206255 31281 64260852
Renal transplant failure 176.66 9.81 92 206507 1548 64290585
Psoriasis 169.95 9.81 561 206038 71142 64220991
Bradycardia 165.40 9.81 86 206513 118133 64174000
Rheumatoid nodule 164.69 9.81 203 206396 12448 64279685
Cerebrovascular accident 162.26 9.81 122 206477 137461 64154672
Glossodynia 161.14 9.81 12 206587 64684 64227449
Pemphigus 160.99 9.81 8 206591 60693 64231440
Smooth muscle cell neoplasm 158.76 9.81 70 206529 796 64291337
Pneumocystis jirovecii pneumonia 157.25 9.81 302 206297 27332 64264801
Ocular hyperaemia 155.58 9.81 268 206331 22296 64269837
Oral administration complication 155.22 9.81 43 206556 92 64292041
Instillation site pain 154.63 9.81 64 206535 615 64291518
Confusional state 154.01 9.81 384 206215 260760 64031373
Viraemia 153.44 9.81 95 206504 2254 64289879
Ulcer 151.93 9.81 268 206331 22722 64269411
Cardiac failure congestive 151.16 9.81 118 206481 130462 64161671
Enthesopathy 150.93 9.81 170 206429 9468 64282665
Mucosal inflammation 149.51 9.81 491 206108 62093 64230040
Pyrexia 149.10 9.81 2564 204035 556080 63736053
Hyponatraemia 147.89 9.81 154 206445 148185 64143948
Weight increased 147.77 9.81 287 206312 213061 64079072
Electrocardiogram QT prolonged 146.25 9.81 37 206562 79411 64212722
Tenosynovitis 146.24 9.81 185 206414 11648 64280485
Therapeutic response decreased 145.49 9.81 432 206167 51756 64240377
Hypoglycaemia 145.37 9.81 53 206546 89839 64202294
Kaposi's sarcoma 145.29 9.81 63 206536 686 64291447
Hand deformity 144.65 9.81 16 206583 62755 64229378
Drug resistance 143.29 9.81 335 206264 34767 64257366
Hyperhidrosis 143.20 9.81 114 206485 124806 64167327
Cardio-respiratory arrest 143.03 9.81 68 206531 98325 64193808
Diffuse large B-cell lymphoma 142.59 9.81 171 206428 10190 64281943
Hypogammaglobulinaemia 141.77 9.81 170 206429 10129 64282004
Malaise 141.22 9.81 721 205878 395526 63896607
Cutaneous T-cell lymphoma 140.79 9.81 90 206509 2262 64289871
JC virus infection 138.31 9.81 102 206497 3253 64288880
Kidney fibrosis 136.28 9.81 98 206501 3003 64289130
Chronic graft versus host disease in intestine 133.37 9.81 46 206553 251 64291882
SLE arthritis 133.36 9.81 54 206545 488 64291645
Back pain 133.07 9.81 387 206212 249784 64042349
Toxicity to various agents 132.03 9.81 657 205942 362856 63929277
Epstein-Barr viraemia 131.07 9.81 78 206521 1719 64290414
Acute myeloid leukaemia recurrent 129.31 9.81 91 206508 2693 64289440
Chorioretinopathy 128.86 9.81 83 206516 2114 64290019
Cytomegalovirus colitis 128.26 9.81 104 206495 3824 64288309
Product dose omission issue 128.01 9.81 270 206329 194477 64097656
Leukaemia recurrent 128.00 9.81 88 206511 2506 64289627
Decreased appetite 127.56 9.81 467 206132 280822 64011311
Suicide attempt 127.03 9.81 35 206564 70972 64221161
Lymphocele 126.97 9.81 74 206525 1567 64290566
Hypokalaemia 126.72 9.81 122 206477 121781 64170352
Cytomegalovirus chorioretinitis 125.54 9.81 113 206486 4799 64287334
Anti-cyclic citrullinated peptide antibody positive 123.98 9.81 9 206590 49553 64242580
Alveolar proteinosis 123.12 9.81 52 206547 528 64291605
Herpes simplex 122.79 9.81 160 206439 10376 64281757
Off label use 122.78 9.81 2768 203831 630038 63662095
Depression 121.40 9.81 253 206346 183038 64109095
Focal segmental glomerulosclerosis 120.23 9.81 89 206510 2855 64289278
Palpitations 120.19 9.81 95 206504 104393 64187740
Scleral hyperaemia 120.16 9.81 42 206557 240 64291893
Red blood cell sedimentation rate increased 119.83 9.81 291 206308 30944 64261189
Skin plaque 118.87 9.81 145 206454 8795 64283338
Abdominal discomfort 118.80 9.81 254 206345 182068 64110065
Therapy non-responder 118.27 9.81 471 206128 65428 64226705
Neurotoxicity 116.76 9.81 266 206333 27138 64264995
Cardiac arrest 115.80 9.81 197 206402 153867 64138266
Lactic acidosis 114.19 9.81 28 206571 61382 64230751
Swelling 114.00 9.81 212 206387 160006 64132127
Overdose 112.77 9.81 212 206387 159354 64132779
Wound 112.46 9.81 52 206547 76425 64215708
Aplasia pure red cell 112.03 9.81 125 206474 6889 64285244
International normalised ratio increased 111.60 9.81 57 206542 79110 64213023
Gastrooesophageal reflux disease 111.17 9.81 64 206535 83079 64209054
Nocardiosis 110.82 9.81 104 206495 4663 64287470
Engraft failure 110.76 9.81 49 206550 562 64291571
Ototoxicity 110.49 9.81 82 206517 2641 64289492
Graft versus host disease in lung 109.87 9.81 53 206546 751 64291382
Abdominal pain upper 109.79 9.81 249 206350 174781 64117352
Hepatitis C 109.72 9.81 155 206444 10860 64281273
Chronic obstructive pulmonary disease 109.72 9.81 45 206554 71003 64221130
Inflammation 108.70 9.81 456 206143 64844 64227289
Blood bilirubin increased 108.68 9.81 418 206181 57135 64234998
Bacterial infection 108.33 9.81 244 206355 24706 64267427
Hypercalcaemia 108.27 9.81 281 206318 31135 64260998
Nasopharyngitis 108.15 9.81 298 206301 195775 64096358
Diarrhoea 105.95 9.81 1654 204945 721050 63571083
Pneumomediastinum 105.89 9.81 82 206517 2818 64289315
Alanine aminotransferase abnormal 105.32 9.81 120 206479 6768 64285365
Systemic lupus erythematosus 104.83 9.81 59 206540 77553 64214580
Epstein-Barr virus infection reactivation 104.82 9.81 58 206541 1108 64291025
End stage renal disease 103.75 9.81 147 206452 10328 64281805
Psoriatic arthropathy 102.85 9.81 339 206260 42942 64249191
Renal tubular atrophy 102.83 9.81 63 206536 1466 64290667
Cystitis viral 102.41 9.81 47 206552 591 64291542
Skin ulcer 102.33 9.81 342 206257 43632 64248501
Disseminated tuberculosis 101.44 9.81 88 206511 3557 64288576
Suicidal ideation 101.38 9.81 43 206556 66499 64225634
Stem cell transplant 100.85 9.81 86 206513 3395 64288738
C-reactive protein increased 100.81 9.81 583 206016 94326 64197807
Tongue disorder 100.22 9.81 156 206443 11924 64280209
Balance disorder 99.46 9.81 74 206525 83852 64208281
Demyelination 99.35 9.81 116 206483 6718 64285415
Injection site pain 98.78 9.81 127 206472 111281 64180852
Myocardial infarction 97.55 9.81 244 206355 165577 64126556
Hirsutism 97.48 9.81 52 206547 921 64291212
Chest pain 97.21 9.81 407 206192 235573 64056560
Flushing 96.27 9.81 67 206532 78581 64213552
Blood lactate dehydrogenase increased 96.19 9.81 278 206321 32800 64259333
Diabetes mellitus 96.08 9.81 445 206154 66029 64226104
Pericarditis 95.88 9.81 40 206559 62476 64229657
Atrial fibrillation 95.86 9.81 258 206341 170831 64121302
Scedosporium infection 95.58 9.81 56 206543 1198 64290935
Staphylococcal infection 93.99 9.81 366 206233 50312 64241821
Loss of consciousness 93.90 9.81 210 206389 148155 64143978
Agitation 93.51 9.81 87 206512 88280 64203853
Arthralgia 92.88 9.81 937 205662 441323 63850810
Bacterial sepsis 92.81 9.81 117 206482 7340 64284793
Elbow deformity 92.02 9.81 55 206544 1222 64290911
Malignant neoplasm progression 91.72 9.81 137 206462 112734 64179399
Eye discharge 90.62 9.81 96 206503 4988 64287145
Pathogen resistance 90.46 9.81 152 206447 12391 64279742
Haemolytic uraemic syndrome 90.18 9.81 86 206513 3935 64288198
Red blood cell sedimentation rate 90.14 9.81 83 206516 3631 64288502
Contusion 90.04 9.81 141 206458 113824 64178309
Pseudomonal sepsis 89.25 9.81 96 206503 5076 64287057
Epstein-Barr virus associated lymphoma 88.26 9.81 48 206551 885 64291248
Duodenal ulcer perforation 87.43 9.81 6 206593 34619 64257514
Skin lesion 86.91 9.81 286 206313 36196 64255937
Viral haemorrhagic cystitis 86.72 9.81 58 206541 1577 64290556
Injection site erythema 85.75 9.81 61 206538 70739 64221394
Nephrotic syndrome 85.65 9.81 128 206471 9439 64282694
Engraftment syndrome 85.61 9.81 50 206549 1063 64291070
Intentional product misuse 85.34 9.81 64 206535 72231 64219902
Osteonecrosis of jaw 84.91 9.81 13 206586 39812 64252321
Fungal infection 84.74 9.81 272 206327 33979 64258154
Toxoplasmosis 84.68 9.81 67 206532 2377 64289756
Haemodialysis 84.41 9.81 176 206423 16901 64275232
Graft versus host disease in eye 84.13 9.81 33 206566 272 64291861
Liver function test abnormal 83.90 9.81 395 206204 59006 64233127
Hypoaesthesia 83.13 9.81 203 206396 138905 64153228
Sedation 82.98 9.81 16 206583 41446 64250687
Complications of transplanted heart 82.90 9.81 33 206566 284 64291849
Blood stem cell transplant failure 81.48 9.81 38 206561 497 64291636
Glomerulosclerosis 81.30 9.81 46 206553 919 64291214
Pulmonary embolism 81.00 9.81 222 206377 146134 64145999
Eye pruritus 80.34 9.81 145 206454 12514 64279619
Wheezing 79.89 9.81 84 206515 80495 64211638
Sepsis 79.46 9.81 1105 205494 229236 64062897
Enterococcal infection 79.45 9.81 152 206447 13714 64278419
Acute myocardial infarction 79.40 9.81 64 206535 69654 64222479
Systemic mycosis 79.03 9.81 63 206536 2260 64289873
Hypertrichosis 79.00 9.81 48 206551 1100 64291033
Blood glucose increased 78.75 9.81 120 206479 97953 64194180
Hospitalisation 78.45 9.81 75 206524 75132 64217001
Pneumonia fungal 78.38 9.81 118 206481 8759 64283374
Sopor 78.36 9.81 4 206595 29657 64262476
Multiple sclerosis relapse 77.96 9.81 18 206581 41117 64251016
Progressive multifocal leukoencephalopathy 77.70 9.81 177 206422 18055 64274078
Red blood cell schistocytes present 77.42 9.81 37 206562 513 64291620
Asthma 76.96 9.81 116 206483 95109 64197024
Graft loss 76.83 9.81 45 206554 962 64291171
Aplastic anaemia 76.59 9.81 150 206449 13770 64278363
Cerebral toxoplasmosis 76.36 9.81 56 206543 1770 64290363
Helicobacter infection 76.36 9.81 15 206584 38347 64253786
Pancytopenia 75.98 9.81 747 205852 142562 64149571
Cryptococcosis 75.63 9.81 66 206533 2689 64289444
Viral test positive 75.49 9.81 33 206566 367 64291766
Serum sickness 74.95 9.81 70 206529 3119 64289014
Orthostatic hypotension 74.80 9.81 28 206571 46710 64245423
Product container issue 74.73 9.81 43 206556 888 64291245
Discomfort 73.98 9.81 90 206509 80788 64211345
Irritable bowel syndrome 73.57 9.81 15 206584 37354 64254779
Aspartate aminotransferase increased 73.35 9.81 644 205955 119144 64172989
Haemolysis 73.34 9.81 129 206470 10910 64281223
Blood iron abnormal 73.28 9.81 46 206553 1119 64291014
Alanine aminotransferase increased 72.87 9.81 723 205876 138308 64153825
Squamous cell carcinoma of skin 72.79 9.81 134 206465 11742 64280391
Insomnia 72.60 9.81 356 206243 197480 64094653
Glomerulonephritis membranous 72.19 9.81 48 206551 1292 64290841
Rash 71.96 9.81 1035 205564 457514 63834619
Bacillary angiomatosis 71.31 9.81 26 206573 171 64291962
Human polyomavirus infection 71.13 9.81 43 206556 976 64291157
Oxygen saturation decreased 70.87 9.81 148 206451 107028 64185105
Bacteraemia 70.51 9.81 218 206381 26693 64265440
Lymphadenopathy 70.03 9.81 316 206283 46370 64245763
Superficial injury of eye 69.86 9.81 23 206576 106 64292027
Hair follicle tumour benign 69.68 9.81 32 206567 403 64291730
Nephrectomy 69.60 9.81 48 206551 1374 64290759
Drug reaction with eosinophilia and systemic symptoms 69.30 9.81 44 206555 54173 64237960
Coombs positive haemolytic anaemia 69.01 9.81 40 206559 838 64291295
Chest discomfort 68.14 9.81 171 206428 115935 64176198
Mycoplasma infection 67.66 9.81 36 206563 634 64291499
Toxic leukoencephalopathy 67.48 9.81 40 206559 875 64291258
Renal tubular necrosis 67.38 9.81 189 206410 21921 64270212
Encephalitis viral 67.32 9.81 58 206541 2322 64289811
Herpes virus infection 66.89 9.81 91 206508 6153 64285980
Varicella zoster virus infection 66.80 9.81 72 206527 3816 64288317
Autoimmune haemolytic anaemia 66.70 9.81 97 206502 6979 64285154
Dyspepsia 66.69 9.81 96 206503 80216 64211917
Acute lymphocytic leukaemia recurrent 66.45 9.81 73 206526 3953 64288180
Feeling abnormal 66.45 9.81 213 206386 133389 64158744
Erythema of eyelid 66.15 9.81 53 206546 1915 64290218
Lung infiltration 66.06 9.81 181 206418 20708 64271425
Klebsiella infection 65.79 9.81 137 206462 13144 64278989
Opportunistic infection 65.60 9.81 60 206539 2602 64289531
Graft complication 65.55 9.81 35 206564 621 64291512
Muscle injury 65.55 9.81 5 206594 26432 64265701
Rectal haemorrhage 65.23 9.81 61 206538 61756 64230377
Pyogenic granuloma 64.98 9.81 31 206568 428 64291705
American trypanosomiasis 64.48 9.81 28 206571 306 64291827
Complications of transplant surgery 64.36 9.81 36 206563 703 64291430
Lower respiratory tract infection 63.95 9.81 129 206470 94485 64197648
Impaired gastric emptying 63.90 9.81 107 206492 8697 64283436
Thrombotic thrombocytopenic purpura 63.78 9.81 87 206512 5897 64286236
Arthropathy 63.61 9.81 188 206411 120779 64171354
Skin mass 63.51 9.81 95 206504 7011 64285122
Leukoencephalopathy 63.50 9.81 94 206505 6873 64285260
Joint swelling 62.63 9.81 418 206181 214964 64077169
Actinic keratosis 62.63 9.81 80 206519 5085 64287048
Leukopenia 62.34 9.81 545 206054 100697 64191436
Serotonin syndrome 62.09 9.81 24 206575 39258 64252875
Pneumatosis intestinalis 61.85 9.81 80 206519 5149 64286984
Steroid diabetes 61.66 9.81 58 206541 2608 64289525
Tachycardia 61.54 9.81 258 206341 149321 64142812
Drug level increased 61.00 9.81 244 206355 33952 64258181
Fusarium infection 60.88 9.81 46 206553 1523 64290610
Pulmonary tuberculosis 60.72 9.81 94 206505 7150 64284983
Delirium 60.17 9.81 80 206519 69114 64223019
Cough 60.12 9.81 648 205951 301500 63990633
C-reactive protein abnormal 59.85 9.81 217 206382 28830 64263303
Acute respiratory distress syndrome 59.49 9.81 265 206334 38670 64253463
Tendonitis 59.49 9.81 171 206428 20111 64272022
Ventricular tachycardia 59.23 9.81 18 206581 34247 64257886
Plasmablastic lymphoma 59.05 9.81 28 206571 381 64291752
Lacrimation increased 59.05 9.81 160 206439 18186 64273947
Septic shock 59.02 9.81 556 206043 104881 64187252
Apoptosis 58.94 9.81 26 206573 296 64291837
Drug tolerance decreased 58.93 9.81 91 206508 6907 64285226
Glomerulonephritis 58.89 9.81 59 206540 2869 64289264
Drug withdrawal syndrome 58.69 9.81 14 206585 31277 64260856
Respiratory arrest 58.65 9.81 50 206549 52935 64239198
Erythrodermic psoriasis 58.42 9.81 45 206554 1534 64290599
Escherichia infection 57.83 9.81 141 206458 15027 64277106
Microangiopathic haemolytic anaemia 57.48 9.81 42 206557 1320 64290813
Heart rate increased 57.38 9.81 146 206453 98529 64193604
Paraesthesia 57.23 9.81 229 206370 134293 64157840
Haptoglobin decreased 56.59 9.81 40 206559 1192 64290941
Unresponsive to stimuli 56.46 9.81 47 206552 50346 64241787
Urinary retention 56.23 9.81 45 206554 49156 64242977
B-cell lymphoma 56.15 9.81 78 206521 5379 64286754
Injury 55.91 9.81 58 206541 55934 64236199
Headache 55.64 9.81 1282 205317 528185 63763948
Deep vein thrombosis 55.64 9.81 163 206436 105019 64187114
Memory impairment 55.24 9.81 120 206479 85562 64206571
Poisoning 54.64 9.81 4 206595 21875 64270258
Infection reactivation 54.46 9.81 48 206551 1982 64290151
Brain abscess 54.27 9.81 67 206532 4114 64288019
Blood potassium decreased 54.13 9.81 31 206568 40368 64251765
Meningoencephalitis herpetic 54.09 9.81 45 206554 1716 64290417
Drug intolerance 53.95 9.81 874 205725 187118 64105015
Serum ferritin increased 53.74 9.81 97 206502 8371 64283762
Laparotomy 53.66 9.81 24 206575 283 64291850
Coronary artery disease 53.44 9.81 69 206530 60364 64231769
Hyperplasia 53.41 9.81 37 206562 1067 64291066
Prescribed overdose 52.90 9.81 3 206596 20328 64271805
Vein rupture 52.82 9.81 42 206557 1501 64290632
General physical health deterioration 52.53 9.81 411 206188 204014 64088119
Rhabdomyolysis 52.49 9.81 486 206113 91240 64200893
Bone marrow failure 52.49 9.81 297 206302 47655 64244478
Herpes zoster 52.29 9.81 433 206166 78754 64213379
Hypertension 52.17 9.81 1141 205458 258120 64034013
Renal transplant 52.17 9.81 49 206550 2199 64289934
Oedema peripheral 52.13 9.81 427 206172 209890 64082243
Systemic candida 51.62 9.81 74 206525 5255 64286878
Coma 51.43 9.81 129 206470 87486 64204647
Biopsy kidney abnormal 51.40 9.81 20 206579 161 64291972
Fear of injection 51.36 9.81 78 206521 5834 64286299
Presyncope 51.36 9.81 24 206575 35065 64257068
Idiopathic pneumonia syndrome 51.26 9.81 28 206571 521 64291612
Renal failure 51.14 9.81 842 205757 180846 64111287
Transient ischaemic attack 51.00 9.81 40 206559 44142 64247991
Hepatosplenic T-cell lymphoma 50.56 9.81 32 206567 790 64291343
Encephalitis 50.23 9.81 119 206480 12452 64279681
Bone marrow transplant rejection 49.99 9.81 22 206577 249 64291884
Complications of transplanted lung 49.86 9.81 25 206574 387 64291746
Device dislocation 49.81 9.81 5 206594 21173 64270960
Lymphocytic infiltration 49.74 9.81 39 206560 1365 64290768
Human herpesvirus 8 infection 49.67 9.81 35 206564 1038 64291095
Unevaluable event 49.63 9.81 53 206546 50436 64241697
Aggression 49.51 9.81 45 206554 46187 64245946
Alternaria infection 49.46 9.81 28 206571 560 64291573
Neuropathy peripheral 49.40 9.81 201 206398 117324 64174809
Drug ineffective for unapproved indication 49.16 9.81 214 206385 30919 64261214
Microangiopathy 49.09 9.81 40 206559 1481 64290652
Acinetobacter infection 48.96 9.81 49 206550 2380 64289753
Blood urea increased 48.68 9.81 274 206325 43879 64248254
Mycobacterium kansasii infection 48.63 9.81 22 206577 267 64291866
Disseminated cryptococcosis 48.05 9.81 40 206559 1527 64290606
Cytomegalovirus syndrome 47.98 9.81 22 206577 276 64291857
Mechanical ventilation 47.98 9.81 48 206551 2330 64289803
Injection site pruritus 47.93 9.81 31 206568 37795 64254338
Enterococcal sepsis 47.87 9.81 49 206550 2445 64289688
Life support 47.83 9.81 25 206574 424 64291709
Loss of personal independence in daily activities 47.74 9.81 396 206203 72058 64220075
Gastroenteritis rotavirus 47.49 9.81 24 206575 378 64291755
Chronic graft versus host disease in eye 47.45 9.81 15 206584 59 64292074
Device expulsion 47.17 9.81 6 206593 21130 64271003
Intentional self-injury 47.15 9.81 17 206582 29027 64263106
Encephalitis cytomegalovirus 47.03 9.81 33 206566 972 64291161
Knee arthroplasty 47.00 9.81 14 206585 26985 64265148
Respiratory tract infection fungal 46.82 9.81 34 206565 1058 64291075
Vertigo 46.60 9.81 73 206526 58938 64233195
Gait disturbance 46.17 9.81 342 206257 171813 64120320
Cushingoid 45.61 9.81 85 206514 7518 64284615
Mycobacterial infection 45.59 9.81 52 206547 2936 64289197
Trichophytic granuloma 45.56 9.81 14 206585 49 64292084
Gouty tophus 45.09 9.81 22 206577 320 64291813
Blood pressure fluctuation 45.07 9.81 60 206539 51811 64240322
Sebaceous hyperplasia 44.91 9.81 14 206585 52 64292081
Weight decreased 44.37 9.81 646 205953 285093 64007040
Sleep disorder 44.23 9.81 77 206522 59632 64232501
Bronchiolitis obliterans syndrome 44.12 9.81 20 206579 244 64291889
Legionella infection 44.00 9.81 28 206571 698 64291435
Post transplant distal limb syndrome 43.94 9.81 25 206574 505 64291628
Renal lymphocele 43.92 9.81 16 206583 105 64292028
Rheumatoid factor positive 43.77 9.81 29 206570 34909 64257224
Skin laceration 43.73 9.81 12 206587 24405 64267728
Myopathy 43.36 9.81 140 206459 17540 64274593
Pustular psoriasis 43.36 9.81 60 206539 4123 64288010
Aplasia 43.30 9.81 79 206520 6874 64285259
Dermatitis exfoliative generalised 43.07 9.81 72 206527 5844 64286289
Staphylococcal sepsis 43.03 9.81 114 206485 12785 64279348
Sinusitis 43.01 9.81 282 206317 145646 64146487
Hallucination 42.85 9.81 107 206492 72681 64219452
Cutaneous mucormycosis 42.80 9.81 16 206583 114 64292019
Sinus tachycardia 42.70 9.81 25 206574 32163 64259970
Reticulocyte count increased 42.69 9.81 33 206566 1131 64291002
Respiratory failure 42.44 9.81 739 205860 160444 64131689
Adenoviral haemorrhagic cystitis 42.09 9.81 24 206575 487 64291646
Microsporidia infection 42 9.81 28 206571 757 64291376
CSF protein increased 42.00 9.81 32 206567 1073 64291060
Hypocalcaemia 41.97 9.81 43 206556 41710 64250423
Influenza like illness 41.80 9.81 84 206515 61618 64230515
Glomerulonephropathy 41.67 9.81 20 206579 280 64291853
Laryngitis fungal 41.64 9.81 16 206583 124 64292009
Head injury 41.49 9.81 27 206572 32815 64259318
Pneumonia viral 41.48 9.81 83 206516 7739 64284394
Cytogenetic abnormality 41.11 9.81 31 206568 1023 64291110
Nephroureterectomy 41.08 9.81 10 206589 9 64292124
Pneumocystis jirovecii infection 41.05 9.81 44 206555 2317 64289816
Stomatitis 40.69 9.81 533 206066 109072 64183061
Pruritus 40.30 9.81 731 205868 311669 63980464
Ureteric stenosis 40.24 9.81 33 206566 1233 64290900
Product use issue 40.08 9.81 696 205903 151019 64141114
Growth retardation 40.07 9.81 36 206563 1525 64290608
Immunosuppression 40.02 9.81 99 206500 10647 64281486
Hepatitis E 39.99 9.81 44 206555 2387 64289746
Cognitive disorder 39.94 9.81 72 206527 55015 64237118
Bone marrow transplant 39.77 9.81 33 206566 1254 64290879
Heart rate irregular 39.74 9.81 19 206580 27394 64264739
Cardiac disorder 39.54 9.81 74 206525 55742 64236391
Visual acuity reduced 39.43 9.81 182 206417 26959 64265174
Mycobacterium chelonae infection 39.24 9.81 41 206558 2096 64290037
Tularaemia 39.21 9.81 14 206585 86 64292047
Dyskinesia 39.10 9.81 41 206558 39347 64252786
Chronic myeloid leukaemia 38.94 9.81 51 206548 3323 64288810
Renal arteriosclerosis 38.90 9.81 18 206581 231 64291902
Hepatosplenomegaly 38.86 9.81 65 206534 5278 64286855
Cutaneous T-cell lymphoma stage IV 38.67 9.81 11 206588 27 64292106
Soft tissue disorder 38.56 9.81 50 206549 3226 64288907
Diabetic ketoacidosis 38.44 9.81 24 206575 29821 64262312
Abnormal behaviour 38.11 9.81 31 206568 33591 64258542
Papilloma viral infection 38.05 9.81 34 206565 1430 64290703
Femur fracture 38.04 9.81 32 206567 34103 64258030
Lethargy 38.02 9.81 113 206486 72481 64219652
Sinus bradycardia 37.85 9.81 13 206586 22880 64269253
Splenomegaly 37.69 9.81 135 206464 17826 64274307
Lupus vasculitis 37.57 9.81 22 206577 470 64291663
Brain stem syndrome 37.40 9.81 26 206573 754 64291379
Renal disorder 37.36 9.81 217 206382 35148 64256985
Hepatitis B 37.32 9.81 79 206520 7666 64284467
Haematemesis 37.24 9.81 58 206541 46941 64245192
Chimerism 37.13 9.81 18 206581 258 64291875
Fungal endocarditis 37.08 9.81 22 206577 482 64291651
Tremor 36.68 9.81 301 206298 147929 64144204
Abdominal pain 36.60 9.81 743 205856 311632 63980501
Road traffic accident 36.55 9.81 27 206572 30718 64261415
Plasmacytoma 36.40 9.81 53 206546 3817 64288316
Infertility 36.37 9.81 22 206577 500 64291633
Corneal endotheliitis 36.33 9.81 12 206587 56 64292077
Renal cell carcinoma 36.32 9.81 68 206531 6036 64286097
Phaeohyphomycosis 36.26 9.81 29 206570 1045 64291088
Glomerulonephritis membranoproliferative 36.10 9.81 22 206577 507 64291626
Candida infection 35.98 9.81 197 206402 31222 64260911
Venous injury 35.94 9.81 23 206576 579 64291554
Disseminated intravascular coagulation 35.83 9.81 201 206398 32147 64259986
Hypoproteinaemia 35.79 9.81 49 206550 3333 64288800
Pulmonary nocardiosis 35.70 9.81 25 206574 734 64291399
Epstein-Barr virus antibody positive 35.63 9.81 23 206576 588 64291545
Restlessness 35.61 9.81 45 206554 39740 64252393
Fluid retention 35.57 9.81 87 206512 59519 64232614
Concomitant disease progression 35.56 9.81 48 206551 3221 64288912
Klebsiella sepsis 35.49 9.81 43 206556 2589 64289544
Ovarian failure 35.49 9.81 22 206577 523 64291610
Central nervous system fungal infection 35.24 9.81 20 206579 402 64291731
Eosinophilia 35.21 9.81 42 206557 38034 64254099
Anuria 35.18 9.81 137 206462 18827 64273306
Abdominal distension 35.03 9.81 173 206426 95821 64196312
Drug dependence 34.99 9.81 33 206566 33279 64258854
Mucoepidermoid carcinoma of salivary gland 34.97 9.81 13 206586 91 64292042
Granuloma 34.66 9.81 70 206529 6571 64285562
Fungal test positive 34.46 9.81 27 206572 944 64291189
Diffuse alveolar damage 34.43 9.81 47 206552 3188 64288945
Escherichia sepsis 34.43 9.81 73 206526 7092 64285041
Lymphadenitis 34.40 9.81 51 206548 3734 64288399
Fungaemia 34.40 9.81 51 206548 3734 64288399
Psoriasis area severity index increased 34.37 9.81 13 206586 96 64292037
Respiratory depression 34.36 9.81 16 206583 23427 64268706
Haematochezia 34.27 9.81 104 206495 66269 64225864
Blast crisis in myelogenous leukaemia 34.26 9.81 25 206574 784 64291349
Pulmonary haemorrhage 34.16 9.81 106 206493 13003 64279130
Overlap syndrome 34.05 9.81 24 206575 712 64291421
Swollen tongue 34.01 9.81 37 206562 34917 64257216
Cytomegalovirus gastrointestinal infection 33.80 9.81 20 206579 436 64291697
Sleep disorder due to general medical condition, insomnia type 33.72 9.81 170 206429 26100 64266033
West Nile viral infection 33.63 9.81 26 206573 891 64291242
Blood beta-D-glucan increased 33.59 9.81 21 206578 507 64291626
Hiatus hernia 33.57 9.81 11 206588 19946 64272187
Neoplasm skin 33.51 9.81 29 206570 1168 64290965
Pneumonia pseudomonal 33.48 9.81 58 206541 4845 64287288
Clear cell renal cell carcinoma 33.38 9.81 38 206561 2141 64289992
Transaminases increased 33.36 9.81 251 206348 44343 64247790
Lymphadenectomy 33.29 9.81 27 206572 993 64291140
Ankylosing spondylitis 32.96 9.81 78 206521 8156 64283977
Behcet's syndrome 32.89 9.81 9 206590 18 64292115
Eyelid oedema 32.66 9.81 100 206499 12179 64279954
Parvovirus B19 infection 32.65 9.81 29 206570 1210 64290923
Laser therapy 32.57 9.81 9 206590 19 64292114
Complications of transplanted liver 32.48 9.81 18 206581 345 64291788
Irritability 32.44 9.81 42 206557 36704 64255429
Necrosis 32.27 9.81 77 206522 8094 64284039
Drug level changed 32.13 9.81 20 206579 479 64291654
Torsade de pointes 32.11 9.81 8 206591 17355 64274778
Angiocentric lymphoma 32.07 9.81 24 206575 783 64291350
Chronic graft versus host disease oral 32.05 9.81 11 206588 59 64292074
Tuberculosis gastrointestinal 31.95 9.81 20 206579 484 64291649
Dysgeusia 31.91 9.81 64 206535 46983 64245150
Cat scratch disease 31.89 9.81 16 206583 248 64291885
Oliguria 31.83 9.81 111 206488 14465 64277668
Drug level fluctuating 31.38 9.81 22 206577 647 64291486
Neutrophil count decreased 31.21 9.81 134 206465 77062 64215071
Depressed mood 31.19 9.81 52 206547 40960 64251173
Renal vein thrombosis 31.17 9.81 19 206580 438 64291695
Oral lichen planus 31.03 9.81 22 206577 659 64291474
Therapeutic product effect variable 31.01 9.81 32 206567 1612 64290521
Bursitis 30.98 9.81 15 206584 21470 64270663
Red blood cell abnormality 30.86 9.81 20 206579 515 64291618
Heart rate decreased 30.84 9.81 83 206516 54984 64237149
Haemorrhagic cyst 30.84 9.81 16 206583 267 64291866
Fear 30.77 9.81 13 206586 20158 64271975
Lepromatous leprosy 30.75 9.81 11 206588 68 64292065
Transurethral bladder resection 30.74 9.81 7 206592 3 64292130
Rotavirus infection 30.73 9.81 21 206578 592 64291541
Myopathy toxic 30.69 9.81 24 206575 837 64291296
Dilatation intrahepatic duct acquired 30.65 9.81 22 206577 672 64291461
Full blood count abnormal 30.65 9.81 30 206569 29727 64262406
Pallor 30.59 9.81 48 206551 38733 64253400
Tumour lysis syndrome 30.52 9.81 12 206587 19428 64272705
Haemosiderosis 30.19 9.81 18 206581 398 64291735
Impaired work ability 30.18 9.81 6 206593 15213 64276920
Bronchitis 30.12 9.81 214 206385 108529 64183604
Porokeratosis 30.10 9.81 15 206584 229 64291904
Cutaneous sporotrichosis 30.09 9.81 9 206590 28 64292105
Acute disseminated encephalomyelitis 29.96 9.81 16 206583 284 64291849
Pneumonia bacterial 29.86 9.81 111 206488 14924 64277209
Haemolytic anaemia 29.80 9.81 116 206483 15937 64276196
Blindness cortical 29.71 9.81 23 206576 790 64291343
Erythema infectiosum 29.69 9.81 14 206585 188 64291945
Secondary immunodeficiency 29.63 9.81 40 206559 2684 64289449
Ventricular fibrillation 29.62 9.81 20 206579 23840 64268293
Reticulocytosis 29.60 9.81 19 206580 481 64291652
Epicondylitis 29.58 9.81 33 206566 1818 64290315
T-cell lymphoma 29.56 9.81 27 206572 1169 64290964
Device issue 29.46 9.81 18 206581 22630 64269503
Acute myeloid leukaemia 29.33 9.81 169 206430 27294 64264839
Throat tightness 29.31 9.81 19 206580 23141 64268992
Wrong technique in product usage process 29.30 9.81 108 206491 64866 64227267
Sweat gland tumour 29.29 9.81 19 206580 490 64291643
Ophthalmic herpes simplex 29.26 9.81 20 206579 564 64291569
Escherichia urinary tract infection 29.23 9.81 95 206504 11942 64280191
Nephrolithiasis 29.13 9.81 60 206539 43623 64248510
Staphylococcal bacteraemia 29.11 9.81 86 206513 10269 64281864
Normal newborn 29.07 9.81 59 206540 5558 64286575
Blood pressure decreased 28.84 9.81 160 206439 86039 64206094
Withdrawal syndrome 28.76 9.81 20 206579 23472 64268661
Laryngitis viral 28.60 9.81 8 206591 18 64292115
Encephalitis fungal 28.57 9.81 13 206586 160 64291973
Bowen's disease 28.57 9.81 12 206587 120 64292013
Cytomegalovirus enterocolitis 28.54 9.81 28 206571 1327 64290806
Pneumonia aspiration 28.41 9.81 96 206503 59175 64232958
Trichophytosis 28.13 9.81 16 206583 323 64291810
Clonal evolution 28.08 9.81 14 206585 214 64291919
Folliculitis 28.00 9.81 33 206566 30044 64262089
Abnormal sensation in eye 27.96 9.81 31 206568 1696 64290437
Chronic myeloid leukaemia recurrent 27.85 9.81 15 206584 271 64291862
Scleroderma 27.83 9.81 53 206546 4765 64287368
Paroxysmal nocturnal haemoglobinuria 27.61 9.81 13 206586 174 64291959
Epstein-Barr virus test positive 27.58 9.81 24 206575 974 64291159
Angina pectoris 27.53 9.81 65 206534 45016 64247117
Atypical mycobacterial infection 27.50 9.81 27 206572 1281 64290852
Medication error 27.47 9.81 76 206523 49890 64242243
Achromobacter infection 27.40 9.81 11 206588 97 64292036
Upper gastrointestinal haemorrhage 27.40 9.81 44 206555 35176 64256957
Angiosarcoma 27.36 9.81 17 206582 406 64291727
Urinary incontinence 27.34 9.81 46 206553 36105 64256028
Urine output decreased 27.30 9.81 115 206484 16377 64275756
Stenotrophomonas infection 27.27 9.81 41 206558 3039 64289094
Fungal sepsis 27.26 9.81 30 206569 1628 64290505
Renal vessel disorder 27.23 9.81 15 206584 284 64291849
IgA nephropathy 27.21 9.81 28 206571 1406 64290727
Keratoacanthoma 27.16 9.81 23 206576 899 64291234
Ischaemic stroke 26.87 9.81 32 206567 29003 64263130
Removal of renal transplant 26.72 9.81 8 206591 25 64292108
Adenovirus reactivation 26.65 9.81 14 206585 240 64291893
Glomerulonephritis proliferative 26.63 9.81 16 206583 359 64291774
Disseminated toxoplasmosis 26.57 9.81 12 206587 145 64291988
Tuberculosis 26.51 9.81 97 206502 12941 64279192
Endotracheal intubation 26.50 9.81 46 206553 3849 64288284
Bone pain 26.42 9.81 72 206527 47500 64244633
Renal tubular injury 26.36 9.81 25 206574 1136 64290997
Papilloedema 26.35 9.81 56 206543 5449 64286684
Pseudomonas aeruginosa meningitis 26.28 9.81 7 206592 12 64292121
Varicella 26.28 9.81 37 206562 2584 64289549
Dyspnoea exertional 26.26 9.81 134 206465 73596 64218537
Human ehrlichiosis 26.24 9.81 16 206583 369 64291764
Organising pneumonia 26.22 9.81 76 206523 8979 64283154
Rib fracture 26.21 9.81 23 206576 24015 64268118
Extrapyramidal disorder 26.20 9.81 15 206584 19537 64272596
Anaplastic large cell lymphoma T- and null-cell types 26.19 9.81 11 206588 110 64292023
Urinary tract infection 26.17 9.81 554 206045 231042 64061091
Peripheral artery aneurysm 26.09 9.81 16 206583 373 64291760
Fibroadenoma of breast 25.99 9.81 14 206585 253 64291880
Peripheral T-cell lymphoma unspecified 25.98 9.81 19 206580 598 64291535
Therapy interrupted 25.96 9.81 16 206583 20020 64272113
Thrombosis 25.95 9.81 127 206472 70515 64221618
Dysphagia 25.92 9.81 218 206381 106594 64185539
Device malfunction 25.90 9.81 12 206587 17621 64274512
Skin toxicity 25.84 9.81 62 206537 6540 64285593
Guttate psoriasis 25.64 9.81 16 206583 385 64291748
Poikiloderma 25.64 9.81 15 206584 320 64291813
Hypertensive encephalopathy 25.59 9.81 22 206577 878 64291255
Pneumonia herpes viral 25.59 9.81 12 206587 159 64291974
Nightmare 25.53 9.81 18 206581 20975 64271158
Underdose 25.51 9.81 27 206572 25802 64266331
Cerebral fungal infection 25.47 9.81 15 206584 324 64291809
White blood cell count decreased 25.47 9.81 354 206245 157483 64134650
Schizophrenia 25.34 9.81 3 206596 11165 64280968
Prescribed underdose 25.33 9.81 13 206586 18002 64274131
Emotional distress 25.33 9.81 48 206551 35990 64256143
Osteonecrosis 25.28 9.81 166 206433 28063 64264070
Iron overload 25.22 9.81 28 206571 1534 64290599
Anaemia 25.18 9.81 975 205624 377705 63914428
Capillary leak syndrome 25.18 9.81 41 206558 3256 64288877
Small intestinal obstruction 25.17 9.81 23 206576 23550 64268583
Eye infection toxoplasmal 25.17 9.81 17 206582 470 64291663
Instillation site reaction 25.15 9.81 15 206584 332 64291801
Osmotic demyelination syndrome 25.12 9.81 25 206574 1206 64290927
Accidental overdose 25.10 9.81 43 206556 33514 64258619
Erectile dysfunction 25.00 9.81 5 206594 12622 64279511
Hyperbilirubinaemia 24.98 9.81 134 206465 21071 64271062
Hepatitis B reactivation 24.88 9.81 51 206548 4838 64287295
Philadelphia positive chronic myeloid leukaemia 24.88 9.81 11 206588 126 64292007
Dysarthria 24.70 9.81 102 206497 59304 64232829
Non-Hodgkin's lymphoma 24.70 9.81 27 206572 1454 64290679
NPM1 gene mutation 24.65 9.81 11 206588 129 64292004
Bronchospasm 24.56 9.81 20 206579 21662 64270471
Productive cough 24.42 9.81 136 206463 73067 64219066
Peripheral swelling 24.31 9.81 498 206101 208655 64083478
Enterobacter infection 24.30 9.81 43 206556 3653 64288480
Blood glucose decreased 24.18 9.81 23 206576 23100 64269033
Atypical mycobacterial pneumonia 24.13 9.81 11 206588 136 64291997
Cytomegalovirus hepatitis 24.00 9.81 18 206581 589 64291544
Therapy cessation 23.97 9.81 42 206557 32447 64259686
Blood calcium decreased 23.82 9.81 28 206571 25526 64266607
Bile duct stenosis 23.82 9.81 29 206570 1755 64290378
Hepatic fibrosis 23.76 9.81 54 206545 5498 64286635
Chloroma 23.73 9.81 19 206580 686 64291447
Arteriosclerosis coronary artery 23.70 9.81 10 206589 15519 64276614
Lymphopenia 23.66 9.81 152 206447 25505 64266628
Tongue ulceration 23.60 9.81 42 206557 3584 64288549
Arterial disorder 23.55 9.81 29 206570 1776 64290357
Perinephric collection 23.51 9.81 14 206585 309 64291824
Ill-defined disorder 23.48 9.81 68 206531 43984 64248149
Sleep apnoea syndrome 23.46 9.81 37 206562 29795 64262338
Injection site warmth 23.40 9.81 7 206592 13455 64278678
Oesophageal squamous cell carcinoma 23.35 9.81 16 206583 453 64291680
Retinal scar 23.32 9.81 15 206584 381 64291752
Colectomy 23.23 9.81 35 206564 2599 64289534
Arrhythmia 23.22 9.81 89 206510 52855 64239278
Papule 23.12 9.81 58 206541 6292 64285841
Nephropathy 22.96 9.81 69 206530 8317 64283816
Ulcerative keratitis 22.96 9.81 38 206561 3059 64289074
Hyperkalaemia 22.94 9.81 210 206389 100919 64191214
Disturbance in attention 22.93 9.81 62 206537 41012 64251121
Urticaria 22.86 9.81 626 205973 146691 64145442
Dysplasia 22.74 9.81 23 206576 1131 64291002
Lymphoid tissue hypoplasia 22.69 9.81 16 206583 475 64291658
Anger 22.68 9.81 11 206588 15730 64276403
Sporotrichosis 22.65 9.81 9 206590 77 64292056
Dry mouth 22.55 9.81 108 206491 60310 64231823
Treatment noncompliance 22.54 9.81 68 206531 43414 64248719
Penicillium infection 22.32 9.81 12 206587 216 64291917
Rash pustular 22.21 9.81 76 206523 9809 64282324
Oral disorder 22.20 9.81 71 206528 8850 64283283
Haematotoxicity 22.19 9.81 91 206508 12805 64279328
Burkholderia cepacia complex infection 22.11 9.81 13 206586 280 64291853
Injection site reaction 22.08 9.81 76 206523 46588 64245545
Cyanosis 22.06 9.81 23 206576 22132 64270001
Phototherapy 22.05 9.81 7 206592 28 64292105
Respiratory syncytial virus infection 22.01 9.81 62 206537 7206 64284927
Neoplasm progression 22.00 9.81 63 206536 40901 64251232
Mental status changes 21.87 9.81 111 206488 61051 64231082
Adrenal suppression 21.80 9.81 24 206575 1303 64290830
Pneumonia adenoviral 21.73 9.81 11 206588 174 64291959
Restless legs syndrome 21.72 9.81 14 206585 17102 64275031
Vaginal haemorrhage 21.72 9.81 18 206581 19326 64272807
Vision blurred 21.61 9.81 408 206191 89908 64202225
Drug-induced liver injury 21.61 9.81 79 206520 47564 64244569
Pneumonia klebsiella 21.60 9.81 43 206556 3994 64288139
Eyelid irritation 21.59 9.81 13 206586 293 64291840
Lung abscess 21.56 9.81 40 206559 3526 64288607
Thymus hypoplasia 21.51 9.81 16 206583 517 64291616
Cytokine release syndrome 21.45 9.81 21 206578 20808 64271325
Generalised oedema 21.41 9.81 127 206472 20726 64271407
Epidermodysplasia verruciformis 21.39 9.81 11 206588 180 64291953
Maternal exposure during pregnancy 21.37 9.81 200 206399 95684 64196449
Vascular graft complication 21.36 9.81 10 206589 132 64292001
Retinal haemorrhage 21.33 9.81 62 206537 7336 64284797
Infective tenosynovitis 21.31 9.81 13 206586 300 64291833
Biliary hamartoma 21.30 9.81 6 206593 14 64292119
Drug level decreased 21.26 9.81 83 206516 11420 64280713
Stevens-Johnson syndrome 21.22 9.81 49 206550 34200 64257933
Eyelids pruritus 21.20 9.81 17 206582 615 64291518
Mania 21.11 9.81 13 206586 16273 64275860
Gastropleural fistula 21.05 9.81 8 206591 60 64292073
Debridement 21.01 9.81 26 206573 1600 64290533
Feeling cold 20.96 9.81 27 206572 23651 64268482
Injection site papule 20.95 9.81 19 206580 815 64291318
Hip fracture 20.94 9.81 34 206565 27065 64265068
Alopecia scarring 20.92 9.81 9 206590 96 64292037
Product delivery mechanism issue 20.90 9.81 10 206589 139 64291994
Adverse drug reaction 20.87 9.81 75 206524 45389 64246744
Toxic encephalopathy 20.79 9.81 74 206525 9741 64282392
Intervertebral disc degeneration 20.76 9.81 8 206591 13112 64279021
CSF cell count increased 20.76 9.81 9 206590 98 64292035
Disorientation 20.72 9.81 100 206499 55728 64236405
Splenic abscess 20.60 9.81 15 206584 469 64291664
Plasma cell myeloma 20.50 9.81 77 206522 45998 64246135
Ewing's sarcoma recurrent 20.47 9.81 6 206593 17 64292116
Parenteral nutrition 20.47 9.81 6 206593 17 64292116
Pollakiuria 20.44 9.81 44 206555 31486 64260647
Impaired healing 20.36 9.81 112 206487 60361 64231772
Hilar lymphadenopathy 20.34 9.81 25 206574 1528 64290605
Limbic encephalitis 20.31 9.81 17 206582 654 64291479
Diffuse large B-cell lymphoma stage IV 20.29 9.81 15 206584 480 64291653
Swelling face 20.24 9.81 109 206490 59057 64233076
Candida sepsis 20.22 9.81 30 206569 2198 64289935
Faeces discoloured 20.15 9.81 32 206567 25697 64266436
Guillain-Barre syndrome 20.14 9.81 62 206537 7573 64284560
Middle insomnia 20.13 9.81 8 206591 12869 64279264
Migraine 20.07 9.81 118 206481 62559 64229574
Angioedema 20.00 9.81 116 206483 61705 64230428
Blood immunoglobulin G decreased 20.00 9.81 33 206566 2650 64289483
Urinary tract infection viral 19.98 9.81 8 206591 70 64292063
Infection 19.91 9.81 752 205847 184128 64108005
Infusion related reaction 19.89 9.81 389 206210 164078 64128055
Embryonal rhabdomyosarcoma 19.88 9.81 7 206592 41 64292092
Flatulence 19.79 9.81 54 206545 35612 64256521
Cryptococcal cutaneous infection 19.71 9.81 10 206589 159 64291974
Neuroendocrine carcinoma of the skin 19.70 9.81 20 206579 988 64291145
Hypomagnesaemia 19.70 9.81 58 206541 37318 64254815
Lupus nephritis 19.68 9.81 31 206568 2393 64289740
Tardive dyskinesia 19.55 9.81 3 206596 9175 64282958
Ocular discomfort 19.51 9.81 41 206558 3958 64288175
Viral infection 19.43 9.81 189 206410 35951 64256182
Pulmonary alveolar haemorrhage 19.42 9.81 72 206527 9666 64282467
Anogenital warts 19.42 9.81 18 206581 794 64291339
Renal mass 19.42 9.81 33 206566 2714 64289419
Marrow hyperplasia 19.30 9.81 23 206576 1361 64290772
Hypotony of eye 19.30 9.81 11 206588 223 64291910
Hyperkeratosis 19.27 9.81 56 206543 6625 64285508
Gastroenteritis norovirus 19.18 9.81 33 206566 2742 64289391
Gastrointestinal haemorrhage 19.17 9.81 303 206296 132009 64160124
Fibrosis 19.15 9.81 45 206554 4683 64287450
Alopecia 19.07 9.81 679 205920 165011 64127122
Neoplasm recurrence 19.02 9.81 39 206560 3700 64288433
Troponin increased 18.99 9.81 13 206586 15386 64276747
Punctal plug insertion 18.99 9.81 4 206595 0 64292133
Gingivectomy 18.99 9.81 4 206595 0 64292133
Erythema 18.99 9.81 756 205843 186314 64105819
Keratolysis exfoliativa acquired 18.98 9.81 5 206594 8 64292125
Leukaemia in remission 18.98 9.81 5 206594 8 64292125
Cold sweat 18.86 9.81 15 206584 16440 64275693
Injection site induration 18.85 9.81 3 206596 8929 64283204
Ventricular extrasystoles 18.84 9.81 17 206582 17512 64274621
Tonsillar hypertrophy 18.77 9.81 22 206577 1279 64290854
Candida pneumonia 18.75 9.81 14 206585 455 64291678
Concomitant disease aggravated 18.73 9.81 80 206519 11462 64280671
Cancer surgery 18.73 9.81 17 206582 730 64291403
Papilloma 18.72 9.81 12 206587 303 64291830
Transplant abscess 18.71 9.81 6 206593 25 64292108
Ureteral necrosis 18.71 9.81 8 206591 84 64292049
Haemorrhoids 18.65 9.81 30 206569 23971 64268162
Cystostomy 18.62 9.81 5 206594 9 64292124
Feeling hot 18.61 9.81 79 206520 45584 64246549
Coombs direct test positive 18.58 9.81 13 206586 381 64291752
Megakaryocytes increased 18.46 9.81 8 206591 87 64292046
Renal infarct 18.44 9.81 30 206569 2381 64289752
Squamous cell carcinoma of the tongue 18.41 9.81 16 206583 648 64291485
Mycobacterium marinum infection 18.32 9.81 13 206586 390 64291743
Adenomatous polyposis coli 18.26 9.81 10 206589 187 64291946
Genital cyst 18.25 9.81 7 206592 54 64292079
Complication associated with device 18.24 9.81 13 206586 15067 64277066
Night sweats 18.23 9.81 57 206542 35989 64256144
Acanthosis 18.23 9.81 13 206586 393 64291740
Pulseless electrical activity 18.20 9.81 9 206590 12730 64279403
Amnesia 18.18 9.81 86 206513 48183 64243950
Fracture 18.08 9.81 20 206579 18735 64273398
Dermatitis atopic 18.06 9.81 39 206560 3837 64288296
Muscle fatigue 18.05 9.81 34 206565 3031 64289102
Gastroenteritis cryptosporidial 18.03 9.81 11 206588 254 64291879
Disseminated Bacillus Calmette-Guerin infection 18.03 9.81 10 206589 192 64291941
Cytomegalovirus enteritis 17.92 9.81 16 206583 672 64291461
Autoimmune neutropenia 17.89 9.81 13 206586 405 64291728
Hyperglycaemia 17.86 9.81 118 206481 60850 64231283
Exercise tolerance increased 17.83 9.81 6 206593 30 64292103
Rheumatoid lung 17.82 9.81 30 206569 2449 64289684
Tongue neoplasm 17.71 9.81 7 206592 59 64292074
Sudden death 17.70 9.81 23 206576 20073 64272060
Joint stiffness 17.65 9.81 45 206554 30359 64261774
Blister 17.56 9.81 170 206429 80797 64211336
Muscle twitching 17.51 9.81 21 206578 18977 64273156
Gastrointestinal mucormycosis 17.51 9.81 12 206587 340 64291793
Infection in an immunocompromised host 17.46 9.81 19 206580 1018 64291115
Hepatomegaly 17.45 9.81 103 206496 16779 64275354
MELAS syndrome 17.41 9.81 9 206590 149 64291984
Product quality issue 17.38 9.81 44 206555 29755 64262378
Lung neoplasm 17.38 9.81 52 206547 6253 64285880
Injection site bruising 17.37 9.81 59 206540 36314 64255819
Skin papilloma 17.37 9.81 46 206553 5157 64286976
Tooth hypoplasia 17.36 9.81 10 206589 207 64291926
Viral myocarditis 17.29 9.81 13 206586 427 64291706
Pregnancy 17.26 9.81 25 206574 20840 64271293
Dystonia 17.24 9.81 21 206578 18844 64273289
Cholelithiasis 17.18 9.81 81 206518 45425 64246708
Erythema multiforme 17.15 9.81 15 206584 15686 64276447
Neuroblastoma recurrent 17.12 9.81 7 206592 65 64292068
CSF pressure increased 17.11 9.81 10 206589 213 64291920
Chills 17.10 9.81 323 206276 136941 64155192
Pneumonia respiratory syncytial viral 17.09 9.81 22 206577 1409 64290724
Toxic skin eruption 17.06 9.81 22 206577 19262 64272871
Rectal cancer metastatic 17.06 9.81 13 206586 436 64291697
Device leakage 16.95 9.81 3 206596 8263 64283870
Mass excision 16.88 9.81 11 206588 286 64291847
Human herpesvirus 6 infection reactivation 16.88 9.81 11 206588 286 64291847
Lung consolidation 16.87 9.81 59 206540 7699 64284434
Globulins decreased 16.85 9.81 12 206587 362 64291771
Foot fracture 16.81 9.81 20 206579 18137 64273996
Limb injury 16.79 9.81 31 206568 23474 64268659
Alpha haemolytic streptococcal infection 16.78 9.81 24 206575 1701 64290432
Blood glucose abnormal 16.69 9.81 4 206595 8909 64283224
Corynebacterium infection 16.68 9.81 18 206581 955 64291178
Mobility decreased 16.67 9.81 185 206414 85655 64206478
Salivary hypersecretion 16.65 9.81 9 206590 12104 64280029
Bile duct stent insertion 16.65 9.81 6 206593 38 64292095
Malignant fibrous histiocytoma 16.58 9.81 7 206592 71 64292062
Pityriasis rubra pilaris 16.58 9.81 7 206592 71 64292062
Intestinal obstruction 16.56 9.81 60 206539 36226 64255907
Toothache 16.42 9.81 19 206580 17440 64274693
Atrioventricular block 16.41 9.81 9 206590 12006 64280127
Asthenopia 16.38 9.81 26 206573 2021 64290112
Type 2 diabetes mellitus 16.37 9.81 55 206544 33965 64258168
Sinus disorder 16.33 9.81 18 206581 16890 64275243
Skin neoplasm excision 16.27 9.81 17 206582 869 64291264
Diabetes mellitus inadequate control 16.24 9.81 27 206572 21294 64270839
Septic vasculitis 16.23 9.81 4 206595 4 64292129
Gastroenteritis clostridial 16.18 9.81 16 206583 766 64291367
Acanthamoeba infection 16.15 9.81 13 206586 473 64291660
Peritonitis 16.07 9.81 136 206463 24887 64267246
Central nervous system lymphoma 16.07 9.81 25 206574 1910 64290223
Injection site rash 16.06 9.81 16 206583 15726 64276407
Non-cardiac chest pain 16.05 9.81 4 206595 8676 64283457
Hepatic failure 16.03 9.81 258 206341 55136 64236997
Laryngeal disorder 16.02 9.81 17 206582 885 64291248
Injection site swelling 15.97 9.81 73 206526 41280 64250853
Morphoea 15.97 9.81 12 206587 394 64291739
Liver abscess 15.95 9.81 45 206554 5235 64286898
Burkitt's lymphoma stage III 15.95 9.81 5 206594 19 64292114
Device related infection 15.89 9.81 159 206440 30467 64261666
Glomerulonephritis minimal lesion 15.88 9.81 15 206584 678 64291455
Body temperature increased 15.85 9.81 62 206537 36604 64255529
Metabolic acidosis 15.81 9.81 148 206451 70810 64221323
Malabsorption 15.80 9.81 40 206559 4363 64287770
Hypertrophy of tongue papillae 15.75 9.81 5 206594 20 64292113
Rash pruritic 15.74 9.81 265 206334 57139 64234994
Lichenification 15.72 9.81 15 206584 687 64291446
Multiple use of single-use product 15.68 9.81 14 206585 588 64291545
Chest expansion decreased 15.64 9.81 9 206590 186 64291947
Neurological symptom 15.62 9.81 53 206546 6811 64285322
Depressed level of consciousness 15.62 9.81 176 206423 81260 64210873
Renal necrosis 15.58 9.81 10 206589 253 64291880
Weber tuning fork test abnormal 15.54 9.81 7 206592 84 64292049
Lung lobectomy 15.50 9.81 8 206591 132 64292001
Respiratory tract infection bacterial 15.49 9.81 16 206583 807 64291326
Gallbladder rupture 15.47 9.81 16 206583 808 64291325
Trichodysplasia spinulosa 15.46 9.81 15 206584 701 64291432
Reticulocyte count decreased 15.41 9.81 15 206584 704 64291429
Jaw fracture 15.39 9.81 30 206569 2744 64289389
Stress 15.39 9.81 122 206477 60412 64231721
Poor quality sleep 15.39 9.81 23 206576 18928 64273205
Disability 15.38 9.81 10 206589 12162 64279971
Cytomegalovirus test 15.35 9.81 6 206593 49 64292084
Adenoviral encephalitis 15.34 9.81 4 206595 6 64292127
Hippocampal sclerosis 15.34 9.81 8 206591 135 64291998
Passenger lymphocyte syndrome 15.33 9.81 7 206592 87 64292046
Brain oedema 15.26 9.81 122 206477 21953 64270180
Renal tubular disorder 15.22 9.81 48 206551 5939 64286194
Moraxella infection 15.21 9.81 13 206586 515 64291618
Subdural haematoma 15.17 9.81 43 206556 28011 64264122
Blood urine present 15.14 9.81 22 206577 18318 64273815
Hydronephrosis 15.13 9.81 87 206512 14038 64278095
Diabetic macroangiopathy 15.13 9.81 8 206591 139 64291994
Cutaneous symptom 15.11 9.81 12 206587 428 64291705
Hepatotoxicity 15.10 9.81 195 206404 39767 64252366
Speech disorder 15.09 9.81 92 206507 48349 64243784
Pathological fracture 15.08 9.81 5 206594 9000 64283133
Lesion excision 15.03 9.81 8 206591 141 64291992
Enterococcal bacteraemia 15.02 9.81 28 206571 2477 64289656
Intervertebral disc protrusion 14.99 9.81 26 206573 20165 64271968
Injection site mass 14.97 9.81 20 206579 17250 64274883
Hypophosphataemia 14.97 9.81 15 206584 14705 64277428
Urticaria pressure 14.96 9.81 4 206595 7 64292126
Post procedural urine leak 14.93 9.81 8 206591 143 64291990
Renal cell carcinoma stage III 14.86 9.81 5 206594 25 64292108
Myasthenic syndrome 14.85 9.81 14 206585 631 64291502
CSF white blood cell count increased 14.85 9.81 7 206592 94 64292039
Thymoma 14.83 9.81 8 206591 145 64291988
Spinal fracture 14.83 9.81 16 206583 15158 64276975
Muscle spasticity 14.76 9.81 19 206580 16650 64275483
Increased appetite 14.75 9.81 7 206592 10139 64281994
Mouth ulceration 14.75 9.81 164 206435 32280 64259853
Human herpes virus 6 serology positive 14.74 9.81 9 206590 208 64291925
Corneal lesion 14.74 9.81 6 206593 55 64292078
Nerve conduction studies abnormal 14.73 9.81 8 206591 147 64291986
Lacrimation decreased 14.72 9.81 11 206588 358 64291775
Retroperitoneal neoplasm 14.70 9.81 5 206594 26 64292107
Psychotic disorder 14.61 9.81 59 206540 34519 64257614
Head discomfort 14.58 9.81 10 206589 11824 64280309
Transitional cell carcinoma 14.58 9.81 26 206573 2223 64289910
Retinal pigment epitheliopathy 14.56 9.81 11 206588 364 64291769
Apathy 14.51 9.81 9 206590 11223 64280910
Caesarean section 14.50 9.81 73 206526 11201 64280932
Pulmonary hypertension 14.47 9.81 80 206519 43059 64249074
Instillation site irritation 14.46 9.81 6 206593 58 64292075
Bradyphrenia 14.45 9.81 6 206593 9400 64282733
Bronchiectasis 14.44 9.81 86 206513 14054 64278079
Prostatic specific antigen increased 14.44 9.81 5 206594 8755 64283378
H1N1 influenza 14.43 9.81 26 206573 2240 64289893
Diverticulitis 14.43 9.81 69 206530 38549 64253584
Trichosporon infection 14.42 9.81 16 206583 876 64291257
Chronic hepatitis 14.38 9.81 19 206580 1249 64290884
Spermatozoa progressive motility decreased 14.37 9.81 6 206593 59 64292074
Vesicoureteric reflux 14.34 9.81 7 206592 102 64292031
Idiopathic intracranial hypertension 14.33 9.81 28 206571 2565 64289568
Chronic kidney disease 14.32 9.81 263 206336 57656 64234477
Adjusted calcium decreased 14.31 9.81 8 206591 156 64291977
Retrograde portal vein flow 14.30 9.81 4 206595 9 64292124
Undifferentiated sarcoma 14.30 9.81 4 206595 9 64292124
Meningococcal sepsis 14.29 9.81 6 206593 60 64292073
Chorioretinal folds 14.24 9.81 5 206594 29 64292104
Citrobacter infection 14.24 9.81 15 206584 774 64291359
Choledocholithotomy 14.24 9.81 3 206596 0 64292133
Peritoneal lavage 14.24 9.81 3 206596 0 64292133
Large cell lung cancer stage IV 14.24 9.81 3 206596 0 64292133
Stent removal 14.24 9.81 3 206596 0 64292133
Biliary sphincterotomy 14.24 9.81 3 206596 0 64292133
Nail candida 14.24 9.81 3 206596 0 64292133
Hepatitis B e antigen 14.24 9.81 3 206596 0 64292133
Bacterial abdominal infection 14.24 9.81 3 206596 0 64292133
Renal cell carcinoma stage II 14.24 9.81 3 206596 0 64292133
Full blood count decreased 14.24 9.81 32 206567 22550 64269583
Hepatitis viral 14.23 9.81 16 206583 889 64291244
Pancreas transplant rejection 14.21 9.81 10 206589 296 64291837
Pulmonary thrombosis 14.19 9.81 8 206591 10510 64281623
Autoimmune hepatitis 14.19 9.81 67 206532 10017 64282116
Device occlusion 14.17 9.81 7 206592 9906 64282227
Corneal perforation 14.16 9.81 14 206585 670 64291463
Gliosis 14.15 9.81 11 206588 380 64291753
Type IIb hyperlipidaemia 14.10 9.81 5 206594 30 64292103
Karyotype analysis abnormal 14.10 9.81 5 206594 30 64292103
Nervousness 14.08 9.81 48 206551 29508 64262625
Stress cardiomyopathy 14.07 9.81 6 206593 9251 64282882
Apnoea 13.96 9.81 8 206591 10414 64281719
Pyelonephritis 13.95 9.81 99 206500 17167 64274966
Tinnitus 13.94 9.81 59 206540 34074 64258059
Neuroendocrine tumour of the lung metastatic 13.92 9.81 7 206592 109 64292024
Mucosal ulceration 13.90 9.81 22 206577 1705 64290428
Acid base balance abnormal 13.89 9.81 10 206589 307 64291826
Haemorrhage intracranial 13.88 9.81 127 206472 23757 64268376
Drug tolerance 13.86 9.81 47 206552 6038 64286095
Splenectomy 13.84 9.81 14 206585 689 64291444
Anal incontinence 13.79 9.81 17 206582 15179 64276954
Central obesity 13.79 9.81 20 206579 1435 64290698
Panic attack 13.79 9.81 29 206570 20924 64271209
Congenital coronary artery malformation 13.78 9.81 6 206593 66 64292067
Product administration error 13.78 9.81 44 206555 27599 64264534
Dizziness postural 13.77 9.81 7 206592 9745 64282388
Scopulariopsis infection 13.75 9.81 7 206592 112 64292021
Aspergillus test positive 13.75 9.81 14 206585 694 64291439
Diffuse large B-cell lymphoma stage I 13.74 9.81 4 206595 11 64292122
Incoherent 13.72 9.81 3 206596 7115 64285018
Bone marrow myelogram abnormal 13.70 9.81 6 206593 67 64292066
Heparin-induced thrombocytopenia 13.70 9.81 5 206594 8474 64283659
Nasal septum disorder 13.70 9.81 7 206592 113 64292020
Eccrine squamous syringometaplasia 13.70 9.81 5 206594 33 64292100
Cold urticaria 13.70 9.81 5 206594 33 64292100
Laboratory test abnormal 13.68 9.81 36 206563 24027 64268106
Peripheral coldness 13.64 9.81 14 206585 13570 64278563
Dermatitis acneiform 13.61 9.81 5 206594 8438 64283695
Product complaint 13.57 9.81 11 206588 11943 64280190
Disseminated varicella zoster vaccine virus infection 13.54 9.81 7 206592 116 64292017
Metastatic malignant melanoma 13.52 9.81 27 206572 2514 64289619
Retinal detachment 13.50 9.81 56 206543 7920 64284213
Steroid dependence 13.48 9.81 11 206588 408 64291725
Hodgkin's disease mixed cellularity stage unspecified 13.48 9.81 4 206595 12 64292121
Hodgkin's disease 13.45 9.81 15 206584 826 64291307
Supraventricular tachycardia 13.45 9.81 25 206574 18882 64273251
Gingival swelling 13.44 9.81 35 206564 3885 64288248
Electrocardiogram abnormal 13.42 9.81 14 206585 13467 64278666
Tooth extraction 13.39 9.81 7 206592 9594 64282539
Visceral leishmaniasis 13.37 9.81 16 206583 951 64291182
Central nervous system lesion 13.37 9.81 74 206525 11775 64280358
Disseminated cytomegaloviral infection 13.35 9.81 11 206588 414 64291719
Pneumonia pneumococcal 13.34 9.81 31 206568 3203 64288930
Eye inflammation 13.33 9.81 40 206559 4817 64287316
Subacute sclerosing panencephalitis 13.33 9.81 5 206594 36 64292097
Cerebrovascular insufficiency 13.32 9.81 7 206592 120 64292013
Central venous pressure increased 13.32 9.81 7 206592 120 64292013
Laryngeal mass 13.32 9.81 6 206593 72 64292061
Pulmonary cavitation 13.29 9.81 19 206580 1346 64290787
Magnetic resonance imaging head abnormal 13.28 9.81 26 206573 2386 64289747
Pulse absent 13.28 9.81 6 206593 8940 64283193
Ureaplasma infection 13.27 9.81 14 206585 724 64291409
Musculoskeletal stiffness 13.25 9.81 297 206302 122909 64169224
Still's disease 13.24 9.81 4 206595 13 64292120
Malignant melanoma stage I 13.22 9.81 7 206592 122 64292011
Aspiration 13.22 9.81 21 206578 16864 64275269
Musculoskeletal pain 13.22 9.81 182 206417 81112 64211021
Hypersomnia 13.22 9.81 27 206572 19690 64272443
Blood loss anaemia 13.19 9.81 15 206584 13877 64278256
Weight fluctuation 13.19 9.81 5 206594 8277 64283856
Endoscopic retrograde cholangiopancreatography 13.18 9.81 6 206593 74 64292059
Rectosigmoid cancer 13.16 9.81 9 206590 254 64291879
Lymphoma 13.11 9.81 83 206516 13858 64278275
Hepatitis C virus test 13.11 9.81 6 206593 75 64292058
Illness 13.10 9.81 32 206567 21906 64270227
Haematuria 13.05 9.81 269 206330 60202 64231931
Nasal congestion 13.05 9.81 125 206474 59533 64232600
Oropharyngeal pain 13.04 9.81 203 206396 88664 64203469
Cranial nerve disorder 13.04 9.81 15 206584 855 64291278
Ketoacidosis 13.01 9.81 3 206596 6860 64285273
Pyelonephritis chronic 13.01 9.81 9 206590 259 64291874
Lactobacillus infection 12.99 9.81 8 206591 188 64291945
Azotaemia 12.95 9.81 53 206546 7449 64284684
Cryptosporidiosis infection 12.94 9.81 13 206586 634 64291499
Polycythaemia 12.91 9.81 23 206576 1964 64290169
Pulmonary arterial hypertension 12.91 9.81 40 206559 25327 64266806
T-cell prolymphocytic leukaemia 12.88 9.81 5 206594 40 64292093
Ileal ulcer 12.84 9.81 16 206583 992 64291141
Oral papilloma 12.80 9.81 4 206595 15 64292118
Urinary bladder haematoma 12.80 9.81 4 206595 15 64292118
Anhedonia 12.80 9.81 15 206584 13691 64278442
Eye infection fungal 12.78 9.81 11 206588 440 64291693
Cord blood transplant therapy 12.77 9.81 5 206594 41 64292092
Renal cell carcinoma stage I 12.77 9.81 5 206594 41 64292092
Photodermatosis 12.74 9.81 15 206584 876 64291257
Herpes simplex reactivation 12.74 9.81 9 206590 268 64291865
Prostatic abscess 12.73 9.81 10 206589 351 64291782
Extra dose administered 12.70 9.81 3 206596 6747 64285386
Neutrophil morphology abnormal 12.70 9.81 6 206593 81 64292052
Anti-platelet antibody positive 12.68 9.81 9 206590 270 64291863
Anaphylactic shock 12.65 9.81 52 206547 30276 64261857
Delusion 12.65 9.81 24 206575 17990 64274143
Dementia 12.63 9.81 30 206569 20736 64271397
Ventricular arrhythmia 12.63 9.81 4 206595 7411 64284722
Squamous cell carcinoma of the cervix 12.62 9.81 8 206591 198 64291935
Ureteral neoplasm 12.60 9.81 4 206595 16 64292117
Disseminated aspergillosis 12.60 9.81 13 206586 655 64291478
Agranulocytosis 12.58 9.81 182 206417 38047 64254086
Pseudolymphoma 12.57 9.81 16 206583 1013 64291120
Intracranial pressure increased 12.57 9.81 50 206549 6939 64285194
Primary effusion lymphoma 12.56 9.81 5 206594 43 64292090
Rheumatoid arthritis 12.52 9.81 645 205954 163649 64128484
Superficial spreading melanoma stage unspecified 12.51 9.81 9 206590 276 64291857
Mood swings 12.51 9.81 23 206576 17445 64274688
Toxoplasma serology positive 12.46 9.81 5 206594 44 64292089
Extrasystoles 12.44 9.81 3 206596 6655 64285478
Abnormal dreams 12.43 9.81 9 206590 10347 64281786
Pain in extremity 12.43 9.81 820 205779 302265 63989868
Adenoviral hepatitis 12.42 9.81 11 206588 457 64291676
Procedural pain 12.42 9.81 19 206580 15489 64276644
Mycobacterium fortuitum infection 12.41 9.81 8 206591 204 64291929
Faciobrachial dystonic seizure 12.41 9.81 4 206595 17 64292116
Eye complication associated with device 12.41 9.81 4 206595 17 64292116
Exostosis 12.40 9.81 11 206588 11427 64280706
Epstein-Barr virus antigen positive 12.38 9.81 6 206593 86 64292047
Benign prostatic hyperplasia 12.32 9.81 7 206592 9158 64282975
Polyomavirus test positive 12.31 9.81 8 206591 207 64291926
Metapneumovirus infection 12.30 9.81 19 206580 1442 64290691
Concussion 12.30 9.81 5 206594 7933 64284200
Gammopathy 12.27 9.81 8 206591 208 64291925
Diffuse axonal injury 12.25 9.81 6 206593 88 64292045
Septic embolus 12.24 9.81 21 206578 1741 64290392
Sebaceous adenoma 12.23 9.81 4 206595 18 64292115
Hepatitis C antibody positive 12.21 9.81 8 206591 210 64291923
Osteoporotic fracture 12.21 9.81 32 206567 3566 64288567
Malignant neoplasm of conjunctiva 12.18 9.81 5 206594 47 64292086
Hyperchromasia 12.17 9.81 3 206596 3 64292130
Transfusion associated graft versus host disease 12.17 9.81 3 206596 3 64292130
Leukaemic infiltration hepatic 12.17 9.81 3 206596 3 64292130
Skin cancer metastatic 12.17 9.81 3 206596 3 64292130
Lymphocele marsupialisation 12.17 9.81 3 206596 3 64292130
Biliary anastomosis 12.17 9.81 3 206596 3 64292130
Nail pterygium 12.17 9.81 3 206596 3 64292130
Coxsackie virus test positive 12.17 9.81 3 206596 3 64292130
Bence Jones protein urine present 12.17 9.81 3 206596 3 64292130
Cardiopulmonary bypass 12.17 9.81 3 206596 3 64292130
Platelet destruction increased 12.17 9.81 3 206596 3 64292130
Peripheral artery dissection 12.17 9.81 3 206596 3 64292130
Conjunctival oedema 12.15 9.81 16 206583 1048 64291085
Keratitis bacterial 12.15 9.81 7 206592 145 64291988
Pulmonary oedema 12.13 9.81 178 206421 78496 64213637
Hip arthroplasty 12.09 9.81 32 206567 21319 64270814
Bronchostenosis 12.09 9.81 12 206587 577 64291556
Retinal infiltrates 12.08 9.81 5 206594 48 64292085
Bronchopneumopathy 12.02 9.81 12 206587 581 64291552
Cold agglutinins positive 11.99 9.81 5 206594 49 64292084
Macule 11.98 9.81 25 206574 2401 64289732
Proteus infection 11.97 9.81 20 206579 1623 64290510
Secondary hypertension 11.94 9.81 8 206591 218 64291915
Eye abscess 11.94 9.81 9 206590 297 64291836
Lip swelling 11.93 9.81 57 206542 31850 64260283
Complement factor C3 decreased 11.91 9.81 9 206590 298 64291835
Splenic artery aneurysm 11.90 9.81 6 206593 94 64292039
Throat irritation 11.90 9.81 59 206540 32652 64259481
Progressive bulbar palsy 11.88 9.81 4 206595 20 64292113
Spindle cell sarcoma 11.85 9.81 8 206591 221 64291912
Injection site urticaria 11.83 9.81 11 206588 11170 64280963
B-cell aplasia 11.81 9.81 7 206592 153 64291980
Serratia infection 11.81 9.81 19 206580 1494 64290639
Intravascular haemolysis 11.79 9.81 13 206586 707 64291426
Renal atrophy 11.78 9.81 20 206579 1644 64290489
Acarodermatitis 11.77 9.81 17 206582 1215 64290918
Antimitochondrial antibody positive 11.73 9.81 6 206593 97 64292036
Rhabdomyosarcoma recurrent 11.73 9.81 6 206593 97 64292036
Vulval cancer stage 0 11.73 9.81 5 206594 52 64292081
Haematoma evacuation 11.73 9.81 9 206590 305 64291828
Pseudallescheria infection 11.72 9.81 4 206595 21 64292112
Cerebrosclerosis 11.72 9.81 4 206595 21 64292112
Cataract 11.72 9.81 230 206369 51032 64241101
Enterocolitis viral 11.70 9.81 9 206590 306 64291827
Biliary anastomosis complication 11.69 9.81 7 206592 156 64291977
Breast pain 11.69 9.81 4 206595 7057 64285076
Thoracotomy 11.68 9.81 6 206593 98 64292035
Bilirubin conjugated abnormal 11.68 9.81 6 206593 98 64292035
Acquired gene mutation 11.66 9.81 22 206577 1964 64290169
Evans syndrome 11.64 9.81 10 206589 399 64291734
Dermatitis allergic 11.63 9.81 19 206580 15090 64277043
Thirst 11.63 9.81 17 206582 14120 64278013
Gastrointestinal candidiasis 11.63 9.81 9 206590 309 64291824
Cardiac valve vegetation 11.61 9.81 14 206585 839 64291294
Haemoglobinuria 11.60 9.81 13 206586 720 64291413
Stenotrophomonas sepsis 11.58 9.81 7 206592 159 64291974
Blood thyroid stimulating hormone increased 11.57 9.81 5 206594 7649 64284484
Human anaplasmosis 11.57 9.81 5 206594 54 64292079
Vasogenic cerebral oedema 11.57 9.81 15 206584 968 64291165
Cardiac failure 11.57 9.81 329 206270 132044 64160089
Respiratory rate increased 11.54 9.81 26 206573 18305 64273828
Ocular pemphigoid 11.52 9.81 6 206593 101 64292032
Hospice care 11.49 9.81 5 206594 7620 64284513
Cytomegalovirus gastrointestinal ulcer 11.49 9.81 5 206594 55 64292078
Myelodysplastic syndrome 11.46 9.81 137 206462 27442 64264691
Lower limb fracture 11.43 9.81 16 206583 13529 64278604
Nasopharyngeal cancer 11.42 9.81 7 206592 163 64291970
Pneumonia lipoid 11.42 9.81 7 206592 163 64291970
Reversible cerebral vasoconstriction syndrome 11.41 9.81 24 206575 2318 64289815
Angina unstable 11.40 9.81 20 206579 15447 64276686
Hypophagia 11.40 9.81 77 206522 39510 64252623
Skin hypopigmentation 11.37 9.81 14 206585 857 64291276
Lymphocyte morphology abnormal 11.36 9.81 14 206585 858 64291275
Delayed graft function 11.34 9.81 28 206571 3008 64289125
Device breakage 11.33 9.81 7 206592 8748 64283385
Polymorphonuclear chromatin clumping 11.31 9.81 3 206596 5 64292128
Eosinophilic pustular folliculitis 11.26 9.81 6 206593 106 64292027
Encephalopathy 11.21 9.81 257 206342 58562 64233571
Needle issue 11.21 9.81 8 206591 9264 64282869
Ocular vascular disorder 11.20 9.81 10 206589 420 64291713
Mycobacterium abscessus infection 11.20 9.81 15 206584 999 64291134
Urinary tract infection pseudomonal 11.18 9.81 18 206581 1416 64290717
Botryomycosis 11.18 9.81 5 206594 59 64292074
Genital neoplasm malignant female 11.18 9.81 5 206594 59 64292074
Hepatitis B surface antigen positive 11.16 9.81 7 206592 170 64291963
Sternotomy 11.14 9.81 4 206595 25 64292108
Retinopathy haemorrhagic 11.10 9.81 5 206594 60 64292073
Infusion site extravasation 11.10 9.81 4 206595 6833 64285300
Abscess drainage 11.10 9.81 11 206588 528 64291605
Skin cancer 11.08 9.81 71 206528 11903 64280230
Aeromonas infection 11.07 9.81 9 206590 332 64291801
Cutaneous lymphoma 11.07 9.81 8 206591 247 64291886
Eye infection staphylococcal 11.06 9.81 6 206593 110 64292023
Mucocutaneous leishmaniasis 11.04 9.81 10 206589 428 64291705
Myocarditis toxoplasmal 11.03 9.81 5 206594 61 64292072
Eructation 11.02 9.81 8 206591 9183 64282950
Nail disorder 11.02 9.81 7 206592 8617 64283516
Refractoriness to platelet transfusion 11.01 9.81 6 206593 111 64292022
Biliary ischaemia 11.01 9.81 4 206595 26 64292107
Noninfective conjunctivitis 11.01 9.81 4 206595 26 64292107
Retching 11.00 9.81 20 206579 15236 64276897
Blood gonadotrophin increased 10.96 9.81 3 206596 6 64292127
Nonkeratinising carcinoma of nasopharynx 10.96 9.81 3 206596 6 64292127
Transfusion microchimerism 10.96 9.81 3 206596 6 64292127
Instillation site dryness 10.96 9.81 3 206596 6 64292127
Granulomatous dermatitis 10.96 9.81 9 206590 337 64291796
Red cell distribution width increased 10.93 9.81 14 206585 12295 64279838
Hot flush 10.93 9.81 95 206504 46140 64245993
Dialysis 10.88 9.81 92 206507 16828 64275305
Activated partial thromboplastin time shortened 10.87 9.81 13 206586 772 64291361
Endocarditis 10.87 9.81 59 206540 9319 64282814
Musculoskeletal chest pain 10.84 9.81 34 206565 21445 64270688
Hallucination, visual 10.83 9.81 49 206550 27785 64264348
Immune thrombocytopenia 10.82 9.81 84 206515 14982 64277151
Sebaceous carcinoma 10.78 9.81 6 206593 116 64292017
Infected dermal cyst 10.78 9.81 13 206586 779 64291354
Lipohypertrophy 10.78 9.81 13 206586 779 64291354
Carotid artery stenosis 10.77 9.81 6 206593 7935 64284198
Ciliary body disorder 10.76 9.81 4 206595 28 64292105
Tonsillitis 10.76 9.81 42 206557 5778 64286355
Multiple fractures 10.76 9.81 3 206596 6037 64286096
Eyelid exfoliation 10.73 9.81 6 206593 117 64292016
Kidney enlargement 10.72 9.81 15 206584 1041 64291092
Onychalgia 10.71 9.81 13 206586 784 64291349
Anaphylactic reaction 10.71 9.81 155 206444 68509 64223624
Hypocomplementaemia 10.71 9.81 7 206592 183 64291950
Sputum discoloured 10.70 9.81 26 206573 17830 64274303
Gastroenteritis adenovirus 10.69 9.81 8 206591 261 64291872
Palatal ulcer 10.69 9.81 6 206593 118 64292015
Hypernatraemia 10.69 9.81 14 206585 12175 64279958
Oral lichenoid reaction 10.68 9.81 5 206594 66 64292067
Therapeutic product effect incomplete 10.68 9.81 419 206180 103063 64189070
Urinoma 10.67 9.81 7 206592 184 64291949
Endocarditis bacterial 10.66 9.81 17 206582 1326 64290807
Necrotising herpetic retinopathy 10.64 9.81 6 206593 119 64292014
Psychomotor disadaptation syndrome 10.64 9.81 4 206595 29 64292104
Cholangitis chronic 10.64 9.81 4 206595 29 64292104
Skin lesion inflammation 10.64 9.81 4 206595 29 64292104
Refractory cytopenia with multilineage dysplasia 10.64 9.81 8 206591 263 64291870
Atelectasis 10.61 9.81 48 206551 27218 64264915
Peripheral vascular disorder 10.57 9.81 5 206594 7256 64284877
Femoral artery aneurysm 10.57 9.81 7 206592 187 64291946
Affect lability 10.55 9.81 8 206591 8982 64283151
Orbital apex syndrome 10.55 9.81 5 206594 68 64292065
Clubbing 10.53 9.81 11 206588 562 64291571
Acute generalised exanthematous pustulosis 10.53 9.81 18 206581 14040 64278093
Herpes zoster meningoencephalitis 10.51 9.81 12 206587 678 64291455
Haematoma 10.50 9.81 96 206503 46154 64245979
Sinus congestion 10.47 9.81 21 206578 15418 64276715
Meningitis cryptococcal 10.45 9.81 27 206572 2982 64289151
Cerebral vasoconstriction 10.44 9.81 16 206583 1206 64290927
Hiccups 10.43 9.81 7 206592 8369 64283764
Spermatozoa progressive motility abnormal 10.41 9.81 4 206595 31 64292102
Infective chondritis 10.41 9.81 4 206595 31 64292102
Mycobacterium avium complex infection 10.40 9.81 32 206567 3908 64288225
Renal hypertension 10.38 9.81 7 206592 193 64291940
Oesophageal candidiasis 10.37 9.81 52 206547 7965 64284168
Decreased activity 10.37 9.81 5 206594 7175 64284958
Necrotising bronchiolitis 10.37 9.81 3 206596 8 64292125
Lichen planus 10.36 9.81 23 206576 2305 64289828
Pseudomembranous colitis 10.36 9.81 37 206562 4879 64287254
Mesangioproliferative glomerulonephritis 10.36 9.81 5 206594 71 64292062
Bone marrow necrosis 10.35 9.81 7 206592 194 64291939
Gastric haemorrhage 10.34 9.81 17 206582 13464 64278669
Musculoskeletal discomfort 10.32 9.81 23 206576 16254 64275879
Bronchoalveolar lavage 10.30 9.81 4 206595 32 64292101
Herpes ophthalmic 10.29 9.81 16 206583 1222 64290911
Gastrointestinal oedema 10.28 9.81 23 206576 2317 64289816
Haemorrhagic stroke 10.28 9.81 10 206589 9941 64282192
Tenderness 10.28 9.81 102 206497 19500 64272633
Metastases to central nervous system 10.25 9.81 18 206581 13894 64278239
Acute promyelocytic leukaemia 10.25 9.81 17 206582 1371 64290762
Rhinovirus infection 10.24 9.81 43 206556 6113 64286020
Upper respiratory tract inflammation 10.24 9.81 31 206568 3751 64288382
Mydriasis 10.24 9.81 21 206578 15291 64276842
Bone tuberculosis 10.23 9.81 10 206589 472 64291661
Hepatitis infectious mononucleosis 10.21 9.81 6 206593 129 64292004
Pneumonia influenzal 10.21 9.81 24 206575 2498 64289635
Parvovirus infection 10.20 9.81 11 206588 583 64291550
Cutaneous T-cell lymphoma stage I 10.20 9.81 4 206595 33 64292100
Keratitis 10.19 9.81 28 206571 3209 64288924
Melaena 10.16 9.81 116 206483 53432 64238701
Nerve injury 10.15 9.81 6 206593 7679 64284454
Acute polyneuropathy 10.12 9.81 9 206590 376 64291757
Herpes zoster cutaneous disseminated 10.12 9.81 9 206590 376 64291757
Occult blood 10.12 9.81 17 206582 1385 64290748
Infusion site pain 10.12 9.81 11 206588 10386 64281747
Tanning 10.11 9.81 5 206594 75 64292058
Hepatobiliary cancer 10.11 9.81 3 206596 9 64292124
Arterial bruit 10.11 9.81 3 206596 9 64292124
Sleep disorder due to a general medical condition 10.09 9.81 7 206592 8227 64283906
Pulmonary sepsis 10.08 9.81 27 206572 3048 64289085
Localised infection 10.08 9.81 56 206543 30105 64262028
Clonic convulsion 10.06 9.81 15 206584 1104 64291029
Papillary renal cell carcinoma 10.05 9.81 6 206593 133 64292000
Tracheostomy 10.05 9.81 15 206584 1105 64291028
Muscle rigidity 10.04 9.81 26 206573 17447 64274686
Renal cortical necrosis 10.03 9.81 8 206591 287 64291846
Pulmonary necrosis 10.02 9.81 10 206589 484 64291649
Blood pressure increased 10.02 9.81 451 206148 172101 64120032
Dental plaque 9.99 9.81 5 206594 77 64292056
Lipids increased 9.99 9.81 17 206582 1400 64290733
Ankle fracture 9.98 9.81 20 206579 14690 64277443
Vitrectomy 9.98 9.81 7 206592 206 64291927
Meningoencephalitis amoebic 9.97 9.81 6 206593 135 64291998
Orchitis 9.97 9.81 15 206584 1113 64291020
Frequent bowel movements 9.94 9.81 28 206571 18277 64273856
Familial mediterranean fever 9.94 9.81 5 206594 78 64292055
Hyperfibrinogenaemia 9.94 9.81 5 206594 78 64292055
Cerebellar syndrome 9.93 9.81 37 206562 4979 64287154
Palmar-plantar erythrodysaesthesia syndrome 9.91 9.81 53 206546 28766 64263367
Meningoradiculitis 9.89 9.81 6 206593 137 64291996
Dental caries 9.89 9.81 12 206587 10788 64281345
Kidney anastomosis 9.87 9.81 3 206596 10 64292123
Urethral dilatation 9.87 9.81 3 206596 10 64292123
Intra-aortic balloon placement 9.87 9.81 3 206596 10 64292123
Blindness 9.87 9.81 111 206488 21908 64270225
Eyelid disorder 9.87 9.81 17 206582 1414 64290719
Telangiectasia 9.87 9.81 15 206584 1123 64291010
Metastases to bone 9.86 9.81 33 206566 20402 64271731
Hepatic artery thrombosis 9.85 9.81 8 206591 295 64291838

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AD01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Calcineurin inhibitors
ATC S01XA18 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA EPC N0000175457 Calcineurin Inhibitor Immunosuppressant
FDA MoA N0000175458 Calcineurin Inhibitors
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:35718 antifungal agents
CHEBI has role CHEBI:35842 anti-rheumatic drugs
CHEBI has role CHEBI:37153 protein serine/threonine phosphatase inhibitors
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:50177 dermatologic agent
CHEBI has role CHEBI:50903 carcinogen
CHEBI has role CHEBI:149553 anticoronaviral drug
CHEBI has role CHEBI:176497 geroprotectors
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
FDA MoA N0000185503 P-Glycoprotein Inhibitors
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D065095 Calcineurin Inhibitors
MeSH PA D003879 Dermatologic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tear film insufficiency indication 46152009
Rheumatoid arthritis indication 69896004 DOID:7148
Kawasaki's disease indication 75053002 DOID:13378
Keratoconjunctivitis sicca indication 302896008 DOID:12895
Prevention of Liver Transplant Rejection indication
Prevention of Cardiac Transplant Rejection indication
Prevention of Kidney Transplant Rejection indication
Severe Recalcitrant Psoriasis indication
Graft-versus-host disease off-label use 234646005
Pure Red Cell Aplasia associated with Chronic Lymphocytic Leukemia off-label use
Prevention of Lung Transplant Rejection off-label use
Prevention of Graft Versus Host Disease off-label use
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Hyperbilirubinemia contraindication 14783006 DOID:2741
Metabolic acidosis, normal anion gap, acidifying salts contraindication 18104000
Hyperuricemia contraindication 35885006 DOID:1920
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Benign intracranial hypertension contraindication 68267002 DOID:11459
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Disorder of brain contraindication 81308009 DOID:936
Kidney disease contraindication 90708001 DOID:557
Neoplasm contraindication 108369006
Malignant lymphoma contraindication 118600007 DOID:0060058
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Toxic nephropathy contraindication 236514003
Hypertriglyceridemia contraindication 302870006
Primary malignant neoplasm contraindication 372087000
Breastfeeding (mother) contraindication 413712001
Hypertensive urgency contraindication 443482000
BK Polyomavirus Reactivation Nephropathy contraindication
Cyclosporine Toxicity contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Allergic dermatitis as manifested by excoriations (including facial and neck), miliary dermatitis, eosinophilic plaques, and self-induced alopecia Indication
Dogs Chronic keratoconjunctivitis sicca (KCS) Indication
Dogs Chronic superficial keratitis (CSK) Indication
Dogs Pruritus associated with allergic dermatitis Indication
Dogs Atopic dermatitis Indication

🐶 Veterinary products

ProductApplicantIngredients
Atopica for Cats Elanco US Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.05% RESTASIS MULTIDOSE ALLERGAN N050790 Oct. 27, 2016 RX EMULSION OPHTHALMIC 8633162 Aug. 27, 2024 INCREASE TEAR PRODUCTION TO TREAT PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.05% RESTASIS MULTIDOSE ALLERGAN N050790 Oct. 27, 2016 RX EMULSION OPHTHALMIC 8648048 Aug. 27, 2024 INCREASE TEAR PRODUCTION IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.05% RESTASIS MULTIDOSE ALLERGAN N050790 Oct. 27, 2016 RX EMULSION OPHTHALMIC 9248191 Aug. 27, 2024 INCREASE TEAR PRODUCTION TO TREAT PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.09% CEQUA SUN PHARM N210913 Aug. 14, 2018 RX SOLUTION OPHTHALMIC 8980839 Aug. 23, 2033 INCREASE TEAR PRODUCTION IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).
0.09% CEQUA SUN PHARM N210913 Aug. 14, 2018 RX SOLUTION OPHTHALMIC 9937225 Aug. 23, 2033 INCREASE TEAR PRODUCTION IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA (DRY EYE).

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
0.1% VERKAZIA SANTEN N214965 June 23, 2021 RX EMULSION OPHTHALMIC June 23, 2023 NEW PRODUCT
0.1% VERKAZIA SANTEN N214965 June 23, 2021 RX EMULSION OPHTHALMIC June 23, 2028 FOR THE TREATMENT OF VERNAL KERATOCONJUNCTIVITIS (VKC) IN CHILDREN AND ADULTS

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Peptidyl-prolyl cis-trans isomerase A Enzyme MODULATOR IC50 8.05 WOMBAT-PK CHEMBL
Multidrug resistance protein 1 Transporter EC50 6.30 WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter IC50 4.87 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP1A Enzyme IC50 7.80 WOMBAT-PK
Dihydroorotate dehydrogenase (quinone), mitochondrial Enzyme IC50 6.70 WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter IC50 5.57 CHEMBL
ATP-binding cassette sub-family G member 2 Transporter IC50 4.20 CHEMBL
fMet-Leu-Phe receptor GPCR ANTAGONIST EC50 6.30 IUPHAR
Bile salt export pump Transporter IC50 6.30 CHEMBL
Solute carrier organic anion transporter family member 1B1 Transporter INHIBITOR Ki 7.29 IUPHAR
Peptidyl-prolyl cis-trans isomerase FKBP4 Enzyme IC50 7.80 CHEMBL
Substance-K receptor GPCR Ki 5.86 DRUG MATRIX
Peptidyl-prolyl cis-trans isomerase B Enzyme Kd 8.01 CHEMBL
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Enzyme Kd 8.40 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP1B Enzyme Ki 8.22 CHEMBL
Peptidyl-prolyl cis-trans isomerase D Enzyme Ki 8.15 CHEMBL
Solute carrier organic anion transporter family member 1B3 Transporter INHIBITOR IC50 6.10 IUPHAR
Sodium/bile acid cotransporter Transporter INHIBITOR IC50 6 IUPHAR
Cytochrome P450 3A4 Enzyme Ki 5.31 WOMBAT-PK
Reverse transcriptase/RNaseH Enzyme IC50 6.34 CHEMBL
Bile salt export pump Transporter IC50 6.22 CHEMBL
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Kinase IC50 6.24 CHEMBL
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Enzyme IC50 4.21 CHEMBL

External reference:

IDSource
4018761 VUID
N0000147064 NUI
D00184 KEGG_DRUG
63798-73-2 SECONDARY_CAS_RN
202817 RXNORM
4018761 VANDF
C0010592 UMLSCUI
CHEBI:4031 CHEBI
CHEMBL160 ChEMBL_ID
5284373 PUBCHEM_CID
DB00091 DRUGBANK_ID
1024 IUPHAR_LIGAND_ID
3027 MMSL
31626 MMSL
4521 MMSL
72396 MMSL
d00079 MMSL
003420 NDDF
387467008 SNOMEDCT_US
80906007 SNOMEDCT_US
D016572 MESH_DESCRIPTOR_UI
5086 INN_ID
26496N541O UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Restasis MultiDose HUMAN PRESCRIPTION DRUG LABEL 1 0023-5301 EMULSION 0.50 mg OPHTHALMIC NDA 24 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 0023-9163 EMULSION 0.50 mg OPHTHALMIC NDA 24 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-0541 CAPSULE 50 mg ORAL ANDA 24 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-3108 CAPSULE 25 mg ORAL ANDA 24 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-3109 CAPSULE 100 mg ORAL ANDA 24 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-6463 CAPSULE 25 mg ORAL ANDA 24 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-6479 CAPSULE 100 mg ORAL ANDA 24 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-7269 SOLUTION 100 mg ORAL ANDA 24 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0109 INJECTION 50 mg INTRAVENOUS NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0109 INJECTION 50 mg INTRAVENOUS NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0110 SOLUTION 100 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0110 SOLUTION 100 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0240 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0240 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0241 CAPSULE, LIQUID FILLED 100 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0241 CAPSULE, LIQUID FILLED 100 mg ORAL NDA 23 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0246 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 23 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0246 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 23 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0248 CAPSULE, LIQUID FILLED 100 mg ORAL NDA 23 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0248 CAPSULE, LIQUID FILLED 100 mg ORAL NDA 23 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0274 SOLUTION 100 mg ORAL NDA 23 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0274 SOLUTION 100 mg ORAL NDA 23 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-5740 CAPSULE, LIQUID FILLED 25 mg ORAL ANDA 16 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-5741 CAPSULE, LIQUID FILLED 50 mg ORAL ANDA 16 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-5742 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 16 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-9018 CAPSULE, LIQUID FILLED 25 mg ORAL ANDA 16 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-9019 CAPSULE, LIQUID FILLED 50 mg ORAL ANDA 16 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-9020 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 16 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 0172-7313 SOLUTION 100 mg ORAL ANDA 23 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 0378-8760 EMULSION 0.50 mg OPHTHALMIC ANDA 23 sections