ciclosporin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
760 59865-13-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • neoral
  • ciclosporin
  • cyclosporine
  • cyclosporin
  • ciclosporine
  • cyclosporin A
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
  • Molecular weight: 1202.64
  • Formula: C62H111N11O12
  • CLOGP: 14.36
  • LIPINSKI: 3
  • HAC: 23
  • HDO: 5
  • TPSA: 278.80
  • ALOGS: -5.10
  • ROTB: 15

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.25 g O
0.25 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.66 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 30 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.07 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 14, 1983 FDA NOVARTIS
Feb. 21, 2020 PMDA Novartis Pharma K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 1559.51 9.70 819 121943 17325 46545975
Eye irritation 1499.63 9.70 775 121987 15839 46547461
Transplant dysfunction 1421.17 9.70 515 122247 4167 46559133
Transplant rejection 1327.85 9.70 600 122162 8996 46554304
Graft versus host disease 991.63 9.70 437 122325 6151 46557149
Acute graft versus host disease 853.76 9.70 341 122421 3689 46559611
Chronic graft versus host disease 812.95 9.70 296 122466 2429 46560871
Product use in unapproved indication 811.83 9.70 1090 121672 89183 46474117
Ovarian cyst 661.92 9.70 430 122332 13657 46549643
Acute graft versus host disease in skin 582.32 9.70 238 122524 2744 46560556
Epstein-Barr virus infection 573.38 9.70 303 122459 6481 46556819
Acne 538.81 9.70 435 122327 19484 46543816
Kidney transplant rejection 486.94 9.70 231 122531 3887 46559413
Graft versus host disease in skin 479.62 9.70 194 122568 2173 46561127
Blood iron abnormal 479.31 9.70 211 122551 2959 46560341
Post transplant lymphoproliferative disorder 421.64 9.70 205 122557 3651 46559649
Graft versus host disease in gastrointestinal tract 415.75 9.70 179 122583 2371 46560929
Foreign body sensation in eyes 394.76 9.70 158 122604 1718 46561582
Acute graft versus host disease in intestine 392.55 9.70 153 122609 1542 46561758
Posterior reversible encephalopathy syndrome 366.34 9.70 310 122452 14831 46548469
Completed suicide 362.03 9.70 4 122758 145916 46417384
Thrombotic microangiopathy 359.68 9.70 241 122521 8065 46555235
Haemophagocytic lymphohistiocytosis 346.79 9.70 236 122526 8106 46555194
Adenovirus infection 341.50 9.70 161 122601 2669 46560631
Renal impairment 336.80 9.70 658 122104 73714 46489586
Eye pain 334.90 9.70 390 122372 27550 46535750
Ocular hyperaemia 305.57 9.70 315 122447 19395 46543905
Nephropathy toxic 300.68 9.70 207 122555 7247 46556053
Cystitis haemorrhagic 292.86 9.70 156 122606 3391 46559909
Immunosuppressant drug level increased 289.88 9.70 151 122611 3131 46560169
Blood creatinine increased 266.85 9.70 608 122154 75795 46487505
BK virus infection 265.81 9.70 136 122626 2713 46560587
Sleep disorder due to general medical condition, insomnia type 255.80 9.70 164 122598 5085 46558215
Blood parathyroid hormone decreased 241.46 9.70 148 122614 4233 46559067
Multiple organ dysfunction syndrome 238.26 9.70 461 122301 51249 46512051
Nausea 238.00 9.70 968 121794 686486 45876814
Panniculitis 229.11 9.70 158 122604 5546 46557754
Granuloma skin 221.89 9.70 129 122633 3341 46559959
Fall 214.55 9.70 334 122428 328763 46234537
Drug ineffective 203.81 9.70 2692 120070 675146 45888154
Cytomegalovirus viraemia 203.71 9.70 134 122628 4344 46558956
Bronchopulmonary aspergillosis 203.26 9.70 164 122598 7332 46555968
Aspergillus infection 200.22 9.70 157 122605 6733 46556567
Instillation site pain 199.85 9.70 79 122683 829 46562471
Acute graft versus host disease in liver 188.94 9.70 69 122693 571 46562729
Product container issue 185.80 9.70 92 122670 1707 46561593
Psoriasis 183.81 9.70 538 122224 78066 46485234
Skin necrosis 183.56 9.70 164 122598 8440 46554860
Fatigue 181.56 9.70 905 121857 607792 45955508
Death 180.73 9.70 383 122379 335165 46228135
Scleral hyperaemia 178.50 9.70 54 122708 227 46563073
Aplastic anaemia 176.18 9.70 148 122614 7005 46556295
Liver transplant rejection 174.04 9.70 81 122681 1302 46561998
Cytomegalovirus test positive 170.22 9.70 101 122661 2719 46560581
Dizziness 169.91 9.70 405 122357 340009 46223291
Drug intolerance 163.92 9.70 793 121969 146256 46417044
Complications of transplanted kidney 163.17 9.70 91 122671 2172 46561128
Eye pruritus 162.85 9.70 178 122584 11720 46551580
Chronic graft versus host disease in skin 157.79 9.70 60 122702 562 46562738
Epstein-Barr virus associated lymphoproliferative disorder 156.81 9.70 77 122685 1402 46561898
Basal cell carcinoma 152.06 9.70 226 122536 20261 46543039
Eye discharge 142.56 9.70 112 122650 4816 46558484
Intentional overdose 141.52 9.70 7 122755 64937 46498363
Obliterative bronchiolitis 137.95 9.70 75 122687 1700 46561600
Liver function test abnormal 137.49 9.70 347 122415 46140 46517160
SLE arthritis 136.07 9.70 54 122708 573 46562727
Hypotension 134.92 9.70 254 122508 232335 46330965
Nephrotic syndrome 134.13 9.70 108 122654 4813 46558487
Graft versus host disease in liver 133.80 9.70 49 122713 409 46562891
Complications of bone marrow transplant 130.01 9.70 48 122714 411 46562889
Constipation 127.86 9.70 162 122600 173935 46389365
Dyspnoea 127.14 9.70 815 121947 514733 46048567
Gingival hypertrophy 126.92 9.70 66 122696 1363 46561937
Chronic allograft nephropathy 126.70 9.70 52 122710 606 46562694
Lacrimation increased 126.46 9.70 181 122581 15680 46547620
Drug abuse 125.93 9.70 11 122751 63397 46499903
Asthenia 125.48 9.70 410 122352 310665 46252635
Epstein-Barr viraemia 124.31 9.70 53 122709 684 46562616
Pseudomonas infection 123.26 9.70 140 122622 9618 46553682
Rheumatoid nodule 121.80 9.70 134 122628 8886 46554414
Vomiting 120.88 9.70 698 122064 452096 46111204
Demyelination 120.64 9.70 108 122654 5572 46557728
Treatment failure 119.94 9.70 524 122238 92563 46470737
Lung transplant rejection 118.88 9.70 52 122710 717 46562583
Venoocclusive liver disease 117.36 9.70 94 122668 4157 46559143
Alveolar proteinosis 115.06 9.70 40 122722 282 46563018
Viraemia 113.12 9.70 55 122707 979 46562321
Focal segmental glomerulosclerosis 113.11 9.70 61 122701 1360 46561940
Human herpesvirus 6 infection 110.97 9.70 73 122689 2366 46560934
Venoocclusive disease 110.15 9.70 67 122695 1889 46561411
Ulcer 109.70 9.70 178 122584 17214 46546086
Anxiety 109.66 9.70 194 122568 181763 46381537
Heart transplant rejection 109.64 9.70 43 122719 441 46562859
Therapeutic response decreased 109.24 9.70 304 122458 42841 46520459
Pneumonia cytomegaloviral 107.46 9.70 66 122696 1894 46561406
Dry eye 105.41 9.70 241 122521 30081 46533219
Elbow deformity 104.33 9.70 57 122705 1305 46561995
Immunosuppressant drug level decreased 100.24 9.70 49 122713 883 46562417
Cerebrovascular accident 98.53 9.70 73 122689 100966 46462334
Mucormycosis 98.01 9.70 66 122696 2226 46561074
Transplant failure 97.50 9.70 53 122709 1201 46562099
Renal transplant failure 96.83 9.70 43 122719 616 46562684
C-reactive protein increased 96.40 9.70 356 122406 58234 46505066
Lymphocele 95.99 9.70 46 122716 792 46562508
Leukaemia recurrent 95.37 9.70 53 122709 1256 46562044
Red blood cell sedimentation rate increased 94.49 9.70 195 122567 22694 46540606
Dehydration 94.41 9.70 172 122590 159368 46403932
Smooth muscle cell neoplasm 93.35 9.70 40 122722 523 46562777
Inflammation 91.96 9.70 310 122452 48471 46514829
Syncope 91.93 9.70 84 122678 104719 46458581
Proteinuria 91.87 9.70 160 122602 16393 46546907
Pain 91.73 9.70 808 121954 476140 46087160
Somnolence 90.62 9.70 171 122591 156350 46406950
Hypogammaglobulinaemia 89.89 9.70 90 122672 5348 46557952
Soft tissue disorder 89.71 9.70 80 122682 4106 46559194
Electrocardiogram QT prolonged 89.30 9.70 14 122748 51311 46511989
Chronic graft versus host disease in liver 86.88 9.70 28 122734 151 46563149
Chorioretinopathy 85.86 9.70 41 122721 700 46562600
Hypercalcaemia 84.19 9.70 177 122585 20869 46542431
Lymphoproliferative disorder 84.01 9.70 64 122698 2628 46560672
Malaise 83.28 9.70 520 122242 330712 46232588
Diarrhoea 82.66 9.70 1009 121753 558593 46004707
Psoriatic arthropathy 82.11 9.70 246 122516 36133 46527167
Back pain 81.72 9.70 281 122481 209758 46353542
Pyrexia 81.03 9.70 1327 121435 347475 46215825
Depression 80.27 9.70 208 122554 169896 46393404
Cutaneous T-cell lymphoma 80.14 9.70 48 122714 1315 46561985
Hepatosplenic T-cell lymphoma 79.70 9.70 37 122725 591 46562709
Oral administration complication 79.62 9.70 25 122737 122 46563178
Skin plaque 79.33 9.70 87 122675 5748 46557552
Polyomavirus viraemia 78.89 9.70 32 122730 361 46562939
Gastrooesophageal reflux disease 78.78 9.70 49 122713 74295 46489005
Skin ulcer 78.53 9.70 225 122537 32233 46531067
Erythema of eyelid 78.17 9.70 53 122709 1808 46561492
Suicide attempt 77.66 9.70 24 122738 55012 46508288
Glossodynia 77.43 9.70 12 122750 44361 46518939
Hirsutism 77.25 9.70 42 122720 952 46562348
Vision blurred 76.21 9.70 412 122350 79296 46484004
Cytomegalovirus infection reactivation 74.22 9.70 47 122715 1425 46561875
Headache 73.05 9.70 856 121906 477496 46085804
Cardio-respiratory arrest 72.93 9.70 33 122729 59836 46503464
Drug tolerance decreased 72.68 9.70 62 122700 2997 46560303
Cytomegalovirus colitis 71.90 9.70 49 122713 1686 46561614
Hyperhidrosis 70.97 9.70 78 122684 89230 46474070
Hyponatraemia 70.55 9.70 98 122664 101234 46462066
Abdominal discomfort 70.42 9.70 186 122576 150979 46412321
Impaired gastric emptying 70.13 9.70 96 122666 7976 46555324
Disease recurrence 70.03 9.70 152 122610 18319 46544981
Glomerulosclerosis 69.74 9.70 28 122734 307 46562993
Drug eruption 69.18 9.70 165 122597 21164 46542136
Muscle spasms 69.06 9.70 137 122625 122976 46440324
Cardiac failure congestive 68.74 9.70 84 122678 91666 46471634
Hypertrichosis 68.32 9.70 38 122724 902 46562398
Aplasia pure red cell 67.26 9.70 70 122692 4355 46558945
Palpitations 66.44 9.70 92 122670 95167 46468133
Hair follicle tumour benign 66.18 9.70 28 122734 354 46562946
Superficial injury of eye 64.29 9.70 22 122740 147 46563153
Stem cell transplant 64.13 9.70 46 122716 1720 46561580
Leukopenia 63.80 9.70 351 122411 67992 46495308
Hypokalaemia 63.43 9.70 83 122679 87941 46475359
Decreased appetite 63.39 9.70 278 122484 193558 46369742
Nephrectomy 63.21 9.70 30 122732 505 46562795
Chronic spontaneous urticaria 62.89 9.70 30 122732 511 46562789
Blood lactate dehydrogenase increased 62.66 9.70 155 122607 20345 46542955
Viral haemorrhagic cystitis 62.27 9.70 31 122731 582 46562718
Weight increased 61.96 9.70 223 122539 164250 46399050
Chronic obstructive pulmonary disease 61.03 9.70 38 122724 57595 46505705
Bradycardia 60.71 9.70 51 122711 66247 46497053
Pathogen resistance 60.25 9.70 77 122685 5983 46557317
Confusional state 60.08 9.70 217 122545 159675 46403625
Epstein-Barr virus associated lymphoma 59.38 9.70 24 122738 268 46563032
Squamous cell carcinoma 58.94 9.70 87 122675 7749 46555551
Insomnia 58.61 9.70 229 122533 164695 46398605
Kidney fibrosis 58.47 9.70 40 122722 1385 46561915
Scedosporium infection 57.61 9.70 28 122734 498 46562802
Renal tubular atrophy 57.30 9.70 28 122734 504 46562796
Sepsis 57.30 9.70 578 122184 135436 46427864
Idiopathic pneumonia syndrome 57.00 9.70 25 122737 347 46562953
Graft complication 56.86 9.70 21 122741 180 46563120
Diffuse large B-cell lymphoma 56.76 9.70 74 122688 5864 46557436
Hand deformity 56.71 9.70 11 122751 34563 46528737
Pneumomediastinum 56.66 9.70 37 122725 1184 46562116
Flushing 56.39 9.70 52 122710 64562 46498738
Dilatation intrahepatic duct acquired 56.15 9.70 31 122731 725 46562575
Abdominal pain upper 56.06 9.70 195 122567 145110 46418190
Loss of consciousness 56.05 9.70 126 122636 108112 46455188
Toxicity to various agents 55.99 9.70 327 122435 211439 46351861
Encephalitis viral 55.88 9.70 41 122721 1589 46561711
Herpes zoster 55.79 9.70 337 122425 67535 46495765
Red blood cell schistocytes present 54.65 9.70 22 122740 243 46563057
Klebsiella infection 54.54 9.70 77 122685 6585 46556715
Injection site pain 54.46 9.70 126 122636 107026 46456274
Alopecia 54.15 9.70 659 122103 161755 46401545
Device expulsion 54.08 9.70 5 122757 27537 46535763
Injection site erythema 53.80 9.70 70 122692 74357 46488943
Graft versus host disease in lung 52.98 9.70 23 122739 311 46562989
Rheumatoid arthritis 52.76 9.70 906 121856 239309 46323991
Herpes simplex 52.61 9.70 79 122683 7144 46556156
International normalised ratio increased 52.35 9.70 29 122733 46854 46516446
Loss of personal independence in daily activities 52.25 9.70 292 122470 56891 46506409
Swelling 52.24 9.70 161 122601 124350 46438950
Nonalcoholic fatty liver disease 52.22 9.70 30 122732 759 46562541
Diabetes mellitus 52.12 9.70 265 122497 49800 46513500
Contusion 52.00 9.70 94 122668 87393 46475907
Blood glucose increased 51.78 9.70 68 122694 71945 46491355
Cardiac arrest 51.20 9.70 100 122662 90299 46473001
Lactic acidosis 51.16 9.70 13 122749 33896 46529404
Feeling abnormal 50.86 9.70 164 122598 124896 46438404
Hypoglycaemia 50.76 9.70 41 122721 54308 46508992
Therapeutic product effect variable 50.70 9.70 33 122729 1050 46562250
Blood bilirubin increased 50.69 9.70 201 122561 33983 46529317
Drug resistance 50.65 9.70 129 122633 17239 46546061
Malignant neoplasm progression 50.16 9.70 58 122704 64868 46498432
Off label use 50.14 9.70 1330 121432 378511 46184789
Multiple sclerosis relapse 50.09 9.70 24 122738 42101 46521199
Acute myeloid leukaemia recurrent 49.87 9.70 36 122726 1360 46561940
Normal newborn 48.59 9.70 69 122693 5932 46557368
Kaposi's sarcoma 48.56 9.70 18 122744 156 46563144
Bone marrow failure 48.55 9.70 180 122582 29489 46533811
Primary hypogonadism 48.46 9.70 18 122744 157 46563143
Product delivery mechanism issue 47.79 9.70 21 122741 293 46563007
Myocardial infarction 47.71 9.70 117 122645 97411 46465889
Toxoplasmosis 47.64 9.70 35 122727 1359 46561941
Pulmonary haemorrhage 47.17 9.70 71 122691 6434 46556866
Laryngitis fungal 47.16 9.70 17 122745 135 46563165
Eyelid irritation 47.13 9.70 22 122740 356 46562944
Atrial fibrillation 47.06 9.70 129 122633 103461 46459839
Aspartate aminotransferase increased 46.91 9.70 361 122401 78339 46484961
Hospitalisation 46.45 9.70 59 122703 63326 46499974
Neurotoxicity 45.44 9.70 107 122655 13610 46549690
Pneumocystis jirovecii pneumonia 45.24 9.70 114 122648 15134 46548166
Cytomegalovirus chorioretinitis 45.21 9.70 35 122727 1472 46561828
Nocardiosis 45.16 9.70 36 122726 1581 46561719
Osteonecrosis of jaw 45.06 9.70 17 122745 34385 46528915
Paraesthesia 45.02 9.70 158 122604 117279 46446021
Leukoencephalopathy 44.82 9.70 54 122708 3950 46559350
Acute lymphocytic leukaemia recurrent 44.82 9.70 40 122722 2055 46561245
Pneumonia viral 44.80 9.70 70 122692 6554 46556746
Alanine aminotransferase increased 44.79 9.70 391 122371 88060 46475240
Varicella zoster virus infection 44.78 9.70 42 122720 2301 46560999
Bacterial sepsis 44.75 9.70 51 122711 3516 46559784
Pustular psoriasis 44.68 9.70 54 122708 3963 46559337
Red blood cell sedimentation rate 44.31 9.70 37 122725 1736 46561564
Drug withdrawal syndrome 44.31 9.70 9 122753 27375 46535925
Hypoaesthesia 44.19 9.70 162 122600 118707 46444593
Enthesopathy 44.14 9.70 58 122704 4632 46558668
Haemolytic uraemic syndrome 44.14 9.70 43 122719 2471 46560829
Autoimmune haemolytic anaemia 43.75 9.70 55 122707 4203 46559097
Eyelid oedema 43.64 9.70 89 122673 10268 46553032
Septic shock 43.54 9.70 281 122481 57612 46505688
Plasma cell myeloma 43.51 9.70 32 122730 44446 46518854
Abnormal sensation in eye 43.24 9.70 36 122726 1682 46561618
Bone marrow transplant 43.08 9.70 25 122737 645 46562655
Complications of transplanted lung 43.02 9.70 18 122744 221 46563079
Wound 42.91 9.70 30 122732 42772 46520528
Device dislocation 42.69 9.70 4 122758 21798 46541502
Product use issue 42.66 9.70 408 122354 94236 46469064
C-reactive protein abnormal 42.59 9.70 138 122624 21132 46542168
Ankylosing spondylitis 42.54 9.70 69 122693 6668 46556632
Asthma 42.33 9.70 113 122649 91429 46471871
Agitation 42.27 9.70 50 122712 55365 46507935
Hepatic function abnormal 42.19 9.70 191 122571 34230 46529070
Pancytopenia 42.04 9.70 374 122388 84684 46478616
Oedema peripheral 41.98 9.70 247 122515 159459 46403841
Nephroureterectomy 41.91 9.70 9 122753 3 46563297
Disseminated intravascular coagulation 41.45 9.70 127 122635 18878 46544422
Balance disorder 41.39 9.70 66 122696 64455 46498845
Systemic candida 41.20 9.70 43 122719 2684 46560616
Multiple use of single-use product 41.09 9.70 24 122738 627 46562673
Cystitis viral 40.98 9.70 14 122748 93 46563207
Chronic graft versus host disease in intestine 40.51 9.70 13 122749 69 46563231
Deep vein thrombosis 40.37 9.70 94 122668 79679 46483621
Serum ferritin increased 40.23 9.70 59 122703 5224 46558076
Pneumatosis intestinalis 40.06 9.70 37 122725 1988 46561312
Intentional product misuse 39.87 9.70 39 122723 47089 46516211
Acute myocardial infarction 39.82 9.70 17 122745 31907 46531393
Pain in extremity 39.69 9.70 462 122300 258218 46305082
Lupus vasculitis 39.60 9.70 21 122741 452 46562848
Blood stem cell transplant failure 39.49 9.70 15 122747 140 46563160
Cough 39.40 9.70 401 122361 229848 46333452
Instillation site reaction 39.31 9.70 21 122741 459 46562841
Drug level increased 39.08 9.70 122 122640 18319 46544981
Nasopharyngitis 38.99 9.70 241 122521 153757 46409543
Suicidal ideation 38.75 9.70 55 122707 56327 46506973
Epicondylitis 38.74 9.70 34 122728 1708 46561592
Lupus nephritis 38.65 9.70 38 122724 2208 46561092
Fusarium infection 38.32 9.70 22 122740 556 46562744
Enterococcal infection 38.07 9.70 67 122695 6920 46556380
Sopor 37.88 9.70 4 122758 19824 46543476
Human polyomavirus infection 37.77 9.70 16 122746 203 46563097
Glomerulonephritis 37.61 9.70 32 122730 1541 46561759
Microangiopathy 37.50 9.70 25 122737 829 46562471
Ocular discomfort 37.41 9.70 43 122719 2992 46560308
Overlap syndrome 37.31 9.70 22 122740 585 46562715
Serum sickness 37.30 9.70 39 122723 2439 46560861
Herpes virus infection 37.28 9.70 54 122708 4728 46558572
Chest pain 37.22 9.70 291 122471 176033 46387267
Heart rate increased 37.15 9.70 89 122673 74702 46488598
Lethargy 37.11 9.70 48 122714 51123 46512177
Hypoproteinaemia 37.09 9.70 34 122728 1809 46561491
Polyomavirus-associated nephropathy 37.04 9.70 31 122731 1459 46561841
Eyelids pruritus 36.65 9.70 22 122740 605 46562695
Gastroenteritis rotavirus 36.65 9.70 13 122749 98 46563202
Clubbing 36.37 9.70 17 122745 276 46563024
Arthralgia 35.74 9.70 710 122052 363893 46199407
Renal tubular necrosis 35.72 9.70 84 122678 10675 46552625
Disseminated tuberculosis 35.63 9.70 40 122722 2712 46560588
Systemic mycosis 35.59 9.70 25 122737 904 46562396
Viral test positive 35.57 9.70 14 122748 145 46563155
Visual acuity reduced 35.21 9.70 133 122629 21980 46541320
Adrenal suppression 35.06 9.70 25 122737 926 46562374
Bronchiolitis obliterans syndrome 34.96 9.70 12 122750 81 46563219
Low birth weight baby 34.79 9.70 56 122706 5378 46557922
Graft loss 34.73 9.70 18 122744 369 46562931
Escherichia urinary tract infection 34.71 9.70 81 122681 10242 46553058
Pulmonary embolism 34.69 9.70 157 122605 108428 46454872
Lung infiltration 34.59 9.70 98 122664 13945 46549355
Graft versus host disease in eye 34.49 9.70 11 122751 57 46563243
Unresponsive to stimuli 34.36 9.70 21 122741 32153 46531147
Transient ischaemic attack 34.28 9.70 25 122737 34878 46528422
Acinetobacter infection 34.15 9.70 29 122733 1393 46561907
JC virus infection 34.11 9.70 31 122731 1631 46561669
Skin lesion 34.07 9.70 150 122612 26563 46536737
Lymphadenectomy 34.06 9.70 24 122738 872 46562428
Blood potassium decreased 33.96 9.70 30 122732 38033 46525267
Dyspepsia 33.59 9.70 82 122680 68390 46494910
Overdose 33.45 9.70 146 122616 101833 46461467
Asthenopia 33.35 9.70 33 122729 1933 46561367
Intentional self-injury 33.26 9.70 11 122751 24155 46539145
Influenza like illness 33.18 9.70 63 122699 57507 46505793
Memory impairment 33.14 9.70 99 122663 77238 46486062
Oxygen saturation decreased 33.02 9.70 84 122678 69080 46494220
Fungaemia 32.99 9.70 33 122729 1958 46561342
Cardiac disorder 32.99 9.70 40 122722 43818 46519482
Tuberculosis gastrointestinal 32.96 9.70 17 122745 345 46562955
Product dose omission issue 32.88 9.70 284 122478 168236 46395064
Systemic lupus erythematosus 32.82 9.70 77 122685 65103 46498197
Gastroenteritis clostridial 32.68 9.70 19 122743 492 46562808
Staphylococcal infection 32.22 9.70 182 122580 35589 46527711
Femur fracture 32.01 9.70 30 122732 36967 46526333
Paroxysmal nocturnal haemoglobinuria 31.94 9.70 13 122749 148 46563152
Mucosal inflammation 31.68 9.70 193 122569 38783 46524517
Muscle fatigue 31.61 9.70 34 122728 2197 46561103
Opportunistic infection 31.57 9.70 30 122732 1671 46561629
T-cell lymphoma 31.51 9.70 20 122742 609 46562691
Eyelid exfoliation 31.41 9.70 12 122750 114 46563186
Clear cell renal cell carcinoma 31.30 9.70 24 122738 995 46562305
Glomerulonephritis membranoproliferative 31.19 9.70 13 122749 158 46563142
Eye inflammation 31.14 9.70 44 122718 3765 46559535
Abdominal pain 31.08 9.70 422 122340 229609 46333691
Pneumonia fungal 31.02 9.70 46 122716 4114 46559186
Respiratory arrest 30.97 9.70 26 122736 33790 46529510
Gouty tophus 30.82 9.70 13 122749 163 46563137
Glomerulonephritis membranous 30.73 9.70 19 122743 552 46562748
Engraftment syndrome 30.70 9.70 15 122747 270 46563030
Capillary leak syndrome 30.63 9.70 31 122731 1866 46561434
Pulmonary tuberculosis 30.62 9.70 49 122713 4682 46558618
Mechanical ventilation 30.56 9.70 26 122736 1252 46562048
Sedation 30.55 9.70 11 122751 22899 46540401
Neoplasm progression 30.52 9.70 16 122746 26667 46536633
Renal tubular injury 30.27 9.70 16 122746 342 46562958
Bacteraemia 30.22 9.70 94 122668 14085 46549215
Fluid retention 30.18 9.70 55 122707 50991 46512309
Complications of transplant surgery 30.13 9.70 13 122749 173 46563127
Renal transplant 30.09 9.70 26 122736 1279 46562021
Arthropathy 29.81 9.70 118 122644 84582 46478718
Engraft failure 29.77 9.70 16 122746 354 46562946
Hiatus hernia 29.64 9.70 6 122756 18296 46545004
Haemolytic anaemia 29.63 9.70 74 122688 9768 46553532
Cognitive disorder 29.52 9.70 32 122730 36851 46526449
Wheezing 29.41 9.70 60 122702 53326 46509974
Lymphocytic infiltration 29.28 9.70 21 122741 785 46562515
Bone pain 29.10 9.70 49 122713 46841 46516459
Ovarian failure 29.07 9.70 24 122738 1108 46562192
Life support 28.90 9.70 14 122748 247 46563053
Knee arthroplasty 28.88 9.70 13 122749 23652 46539648
Condition aggravated 28.86 9.70 846 121916 244206 46319094
Instillation site irritation 28.84 9.70 11 122751 104 46563196
Psoriasis area severity index increased 28.82 9.70 9 122753 43 46563257
Tenosynovitis 28.66 9.70 62 122700 7453 46555847
Cytomegalovirus enterocolitis 28.59 9.70 18 122744 540 46562760
Chest discomfort 28.54 9.70 131 122631 90138 46473162
Drug level fluctuating 28.46 9.70 16 122746 388 46562912
Lymphocele marsupialisation 28.42 9.70 7 122755 10 46563290
Chronic graft versus host disease in eye 28.42 9.70 7 122755 10 46563290
Renal mass 28.33 9.70 29 122733 1769 46561531
Splenomegaly 28.29 9.70 72 122690 9616 46553684
Eye swelling 28.04 9.70 116 122646 19987 46543313
Delirium 27.95 9.70 34 122728 37194 46526106
Orthostatic hypotension 27.89 9.70 15 122747 24643 46538657
Gastrointestinal mucormycosis 27.86 9.70 12 122750 159 46563141
Sinus tachycardia 27.85 9.70 11 122751 21638 46541662
Haptoglobin decreased 27.84 9.70 18 122744 566 46562734
Blood urea increased 27.65 9.70 136 122626 25216 46538084
Anti-cyclic citrullinated peptide antibody positive 27.63 9.70 8 122754 19137 46544163
Blast crisis in myelogenous leukaemia 27.58 9.70 17 122745 491 46562809
Enterococcal sepsis 27.51 9.70 25 122737 1315 46561985
Pseudomonal sepsis 27.47 9.70 30 122732 1972 46561328
Haemodialysis 27.44 9.70 69 122693 9148 46554152
Bone marrow transplant rejection 27.41 9.70 9 122753 52 46563248
Thrombotic thrombocytopenic purpura 27.39 9.70 42 122720 3868 46559432
Eye infection toxoplasmal 27.15 9.70 14 122748 284 46563016
Renal arteriosclerosis 26.71 9.70 9 122753 57 46563243
American trypanosomiasis 26.71 9.70 9 122753 57 46563243
Hepatitis C 26.27 9.70 54 122708 6264 46557036
Angiocentric lymphoma 26.24 9.70 16 122746 453 46562847
Skin laceration 26.22 9.70 8 122754 18494 46544806
Hepatosplenomegaly 26.16 9.70 32 122730 2378 46560922
Laryngeal disorder 26.00 9.70 20 122742 833 46562467
Eye infection fungal 25.90 9.70 10 122752 98 46563202
Epstein-Barr virus infection reactivation 25.69 9.70 13 122749 253 46563047
Bursitis 25.66 9.70 10 122752 19832 46543468
Stenotrophomonas sepsis 25.66 9.70 8 122754 38 46563262
Weight decreased 25.61 9.70 395 122367 210454 46352846
Cushingoid 25.41 9.70 53 122709 6213 46557087
Cytomegalovirus syndrome 25.37 9.70 10 122752 104 46563196
Unevaluable event 25.34 9.70 52 122710 46123 46517177
Abdominal distension 25.30 9.70 103 122659 73248 46490052
Gait disturbance 25.23 9.70 252 122510 145011 46418289
Hepatitis E 25.21 9.70 23 122739 1216 46562084
Post transplant distal limb syndrome 25.18 9.70 12 122750 204 46563096
Bronchostenosis 25.14 9.70 14 122748 333 46562967
Madarosis 24.92 9.70 27 122735 1759 46561541
Nasal septum disorder 24.88 9.70 10 122752 110 46563190
Blood count abnormal 24.85 9.70 8 122754 17870 46545430
Hilar lymphadenopathy 24.79 9.70 21 122741 1005 46562295
Respiratory tract infection bacterial 24.74 9.70 11 122751 158 46563142
Presyncope 24.70 9.70 17 122745 24437 46538863
Bacillary angiomatosis 24.69 9.70 9 122753 74 46563226
Ventricular tachycardia 24.66 9.70 7 122755 16960 46546340
Rectal haemorrhage 24.66 9.70 39 122723 38216 46525084
Hairy cell leukaemia 24.48 9.70 7 122755 23 46563277
Fibroadenoma of breast 24.41 9.70 14 122748 353 46562947
Drug reaction with eosinophilia and systemic symptoms 24.36 9.70 25 122737 29523 46533777
Fear of injection 24.21 9.70 41 122721 4106 46559194
Throat tightness 24.17 9.70 12 122750 20627 46542673
Central obesity 24.16 9.70 19 122743 818 46562482
Restlessness 24.15 9.70 19 122743 25505 46537795
Pulmonary alveolar haemorrhage 24.10 9.70 41 122721 4121 46559179
Guttate psoriasis 24.06 9.70 14 122748 363 46562937
Product storage error 24.05 9.70 77 122685 11715 46551585
Infertility 23.95 9.70 17 122745 625 46562675
Poisoning 23.93 9.70 4 122758 13990 46549310
Tremor 23.85 9.70 192 122570 115447 46447853
Microsporidia infection 23.83 9.70 12 122750 231 46563069
Toxic leukoencephalopathy 23.83 9.70 16 122746 537 46562763
Injury 23.81 9.70 50 122712 43977 46519323
Eye complication associated with device 23.80 9.70 6 122756 10 46563290
Renal lymphocele 23.79 9.70 9 122753 83 46563217
Anuria 23.64 9.70 75 122687 11356 46551944
Encapsulating peritoneal sclerosis 23.55 9.70 14 122748 378 46562922
Respiratory failure 23.50 9.70 365 122397 94451 46468849
Cutaneous T-cell lymphoma stage IV 23.44 9.70 6 122756 11 46563289
Gastropleural fistula 23.44 9.70 8 122754 53 46563247
Injection site swelling 23.35 9.70 44 122718 40283 46523017
Escherichia infection 23.32 9.70 72 122690 10745 46552555
Growth failure 23.21 9.70 13 122749 313 46562987
Complications of transplanted heart 23.18 9.70 8 122754 55 46563245
Jaw fracture 23.18 9.70 31 122731 2518 46560782
Emotional distress 23.10 9.70 28 122734 30679 46532621
Behcet's syndrome 22.55 9.70 9 122753 97 46563203
Tongue disorder 22.54 9.70 55 122707 7155 46556145
Burkholderia cepacia complex infection 22.47 9.70 10 122752 144 46563156
Haematuria 22.46 9.70 134 122628 26724 46536576
Injection site pruritus 22.46 9.70 44 122718 39699 46523601
Therapy non-responder 22.45 9.70 185 122577 40967 46522333
Encephalitis 22.42 9.70 56 122706 7392 46555908
Transurethral bladder resection 22.38 9.70 5 122757 3 46563297
Epistaxis 22.36 9.70 90 122672 64215 46499085
Concomitant disease progression 22.33 9.70 28 122734 2134 46561166
Brain abscess 22.33 9.70 25 122737 1690 46561610
Red blood cell abnormality 22.23 9.70 12 122750 268 46563032
Globulins decreased 22.22 9.70 11 122751 204 46563096
Coronary artery disease 22.14 9.70 34 122728 33718 46529582
Alopecia scarring 22.07 9.70 9 122753 103 46563197
Road traffic accident 21.96 9.70 18 122744 23673 46539627
Chronic graft versus host disease oral 21.84 9.70 7 122755 37 46563263
Steroid diabetes 21.81 9.70 16 122746 620 46562680
Skin mass 21.81 9.70 45 122717 5235 46558065
Neoplasm recurrence 21.80 9.70 29 122733 2344 46560956
Tachycardia 21.67 9.70 163 122599 99459 46463841
Ocular vascular disorder 21.45 9.70 13 122749 364 46562936
Microangiopathic haemolytic anaemia 21.44 9.70 14 122748 448 46562852
Fungal infection 21.40 9.70 142 122620 29378 46533922
MELAS syndrome 21.40 9.70 9 122753 112 46563188
Acute respiratory distress syndrome 21.40 9.70 114 122648 21808 46541492
Device issue 21.39 9.70 13 122749 19967 46543333
Dysplasia 21.34 9.70 16 122746 641 46562659
Head injury 21.28 9.70 20 122742 24616 46538684
Product use complaint 21.21 9.70 25 122737 1787 46561513
Fear 21.16 9.70 8 122754 16164 46547136
Pneumocystis jirovecii infection 21.14 9.70 21 122741 1236 46562064
Thrombosis 21.09 9.70 76 122686 55993 46507307
Apoptosis 20.94 9.70 8 122754 76 46563224
Lichenification 20.77 9.70 13 122749 386 46562914
Diabetic ketoacidosis 20.71 9.70 11 122751 18199 46545101
Blood glucose decreased 20.64 9.70 12 122750 18880 46544420
Blood pressure fluctuation 20.63 9.70 30 122732 30418 46532882
Vertigo 20.63 9.70 69 122693 51979 46511321
Retinal haemorrhage 20.62 9.70 42 122720 4841 46558459
Underdose 20.56 9.70 13 122749 19545 46543755
Occult blood 20.55 9.70 18 122744 902 46562398
Pneumonia lipoid 20.32 9.70 9 122753 128 46563172
Adverse drug reaction 20.31 9.70 55 122707 44307 46518993
Genital cyst 20.30 9.70 7 122755 48 46563252
Fungal endocarditis 20.28 9.70 11 122751 248 46563052
Rectal cancer metastatic 20.24 9.70 11 122751 249 46563051
Hip fracture 20.21 9.70 24 122738 26532 46536768
Lymphadenopathy 20.16 9.70 154 122608 33334 46529966
Injection site haemorrhage 20.12 9.70 15 122747 20694 46542606
Neuropathy peripheral 20.11 9.70 148 122614 90745 46472555
Pneumonia adenoviral 20.07 9.70 6 122756 24 46563276
Procedural pain 19.98 9.70 5 122757 13174 46550126
Leukaemia in remission 19.96 9.70 5 122757 8 46563292
Hallucination 19.94 9.70 66 122696 49885 46513415
Oesophageal candidiasis 19.94 9.70 43 122719 5157 46558143
Cerebral toxoplasmosis 19.93 9.70 16 122746 710 46562590
Laser therapy 19.87 9.70 6 122756 25 46563275
Cord blood transplant therapy 19.77 9.70 4 122758 0 46563300
Interstitial lung disease 19.76 9.70 223 122539 53726 46509574
Premature labour 19.71 9.70 70 122692 11229 46552071
Hypertension 19.70 9.70 665 122097 195691 46367609
Torsade de pointes 19.65 9.70 4 122758 12150 46551150
Chorioretinal folds 19.59 9.70 5 122757 9 46563291
Hepatitis B 19.59 9.70 35 122727 3658 46559642
Renal failure 19.57 9.70 413 122349 113181 46450119
Ulcerative keratitis 19.51 9.70 27 122735 2266 46561034
Coma 19.46 9.70 83 122679 58266 46505034
Sinus bradycardia 19.45 9.70 6 122756 13776 46549524
Skin hypopigmentation 19.42 9.70 12 122750 348 46562952
Serotonin syndrome 19.40 9.70 21 122741 24199 46539101
Staphylococcal bacteraemia 19.32 9.70 41 122721 4863 46558437
Renal cortical necrosis 19.28 9.70 8 122754 96 46563204
Primary effusion lymphoma 19.25 9.70 5 122757 10 46563290
Iron overload 19.25 9.70 16 122746 746 46562554
Withdrawal syndrome 19.13 9.70 12 122750 18122 46545178
Renal disorder 19.12 9.70 128 122634 26558 46536742
Papilloedema 19.10 9.70 34 122728 3543 46559757
Migraine 19.08 9.70 107 122655 69919 46493381
Myocarditis 19.05 9.70 54 122708 7685 46555615
Product packaging quantity issue 19.03 9.70 19 122743 1125 46562175
Liver disorder 19.02 9.70 165 122597 37081 46526219
Staphylococcal sepsis 18.98 9.70 53 122709 7479 46555821
Infected dermal cyst 18.98 9.70 13 122749 451 46562849
Acute myeloid leukaemia 18.92 9.70 87 122675 15691 46547609
Photophobia 18.80 9.70 82 122680 14462 46548838
Penicillium infection 18.78 9.70 8 122754 103 46563197
Pyoderma gangrenosum 18.77 9.70 29 122733 2688 46560612
Impaired work ability 18.76 9.70 5 122757 12631 46550669
Rash pustular 18.70 9.70 50 122712 6879 46556421
Progressive multifocal leukoencephalopathy 18.69 9.70 69 122693 11277 46552023
Eyelid margin crusting 18.63 9.70 15 122747 668 46562632
Adjusted calcium decreased 18.57 9.70 8 122754 106 46563194
Medication error 18.54 9.70 33 122729 30878 46532422
Cholelithiasis 18.44 9.70 47 122715 38634 46524666
Bacterial infection 18.41 9.70 88 122674 16128 46547172
Stenotrophomonas infection 18.38 9.70 22 122740 1598 46561702
Inappropriate schedule of product administration 18.35 9.70 256 122506 64757 46498543
Periportal oedema 18.35 9.70 5 122757 13 46563287
Urinary retention 18.33 9.70 25 122737 26036 46537264
Intervertebral disc protrusion 18.30 9.70 16 122746 20389 46542911
Phaeohyphomycosis 18.18 9.70 10 122752 232 46563068
Infection 18.18 9.70 470 122292 133122 46430178
Lacrimation decreased 18.16 9.70 12 122750 392 46562908
Hypertrophy of tongue papillae 18.08 9.70 5 122757 14 46563286
Lysozyme increased 18.08 9.70 5 122757 14 46563286
Growth retardation 18.02 9.70 17 122745 938 46562362
Metastases to liver 18.00 9.70 15 122747 19570 46543730
Foot fracture 18.00 9.70 15 122747 19567 46543733
Corynebacterium infection 17.94 9.70 12 122750 400 46562900
Plasmablastic lymphoma 17.88 9.70 10 122752 240 46563060
Complications of transplanted liver 17.84 9.70 12 122750 404 46562896
Disseminated varicella zoster virus infection 17.81 9.70 15 122747 712 46562588
Respiratory tract infection fungal 17.81 9.70 12 122750 405 46562895
Mycobacterium kansasii infection 17.74 9.70 8 122754 119 46563181
Discomfort 17.73 9.70 63 122699 46607 46516693
Haemolysis 17.66 9.70 45 122717 6014 46557286
Encephalitis cytomegalovirus 17.60 9.70 13 122749 509 46562791
Urinary incontinence 17.53 9.70 30 122732 28500 46534800
Skin haemorrhage 17.43 9.70 44 122718 5847 46557453
Restless legs syndrome 17.39 9.70 10 122752 15833 46547467
Laryngitis viral 17.36 9.70 5 122757 17 46563283
Rash 17.26 9.70 764 121998 355748 46207552
Chloroma 17.21 9.70 9 122753 188 46563112
Abnormal behaviour 17.15 9.70 18 122744 21040 46542260
Lacrimal disorder 17.13 9.70 9 122753 190 46563110
Dyspnoea exertional 17.10 9.70 71 122691 50218 46513082
Haematemesis 17.06 9.70 31 122731 28775 46534525
Erythema 17.04 9.70 494 122268 142326 46420974
Septic vasculitis 17.01 9.70 4 122758 4 46563296
Full blood count decreased 16.98 9.70 20 122742 22191 46541109
Adenoviral haemorrhagic cystitis 16.94 9.70 8 122754 133 46563167
Biopsy kidney abnormal 16.94 9.70 6 122756 45 46563255
Pneumonia bacterial 16.94 9.70 48 122714 6831 46556469
Muscular weakness 16.92 9.70 157 122605 91687 46471613
Cerebral vasoconstriction 16.89 9.70 17 122745 1016 46562284
Weber tuning fork test abnormal 16.87 9.70 7 122755 84 46563216
General physical health deterioration 16.86 9.70 209 122553 115560 46447740
Panic attack 16.83 9.70 17 122745 20225 46543075
Oliguria 16.79 9.70 56 122706 8703 46554597
Laparotomy 16.78 9.70 8 122754 136 46563164
Hypertensive encephalopathy 16.76 9.70 14 122748 657 46562643
Diffuse alveolar damage 16.72 9.70 15 122747 776 46562524
Hyperplasia 16.69 9.70 14 122748 661 46562639
Psychotic disorder 16.62 9.70 21 122741 22600 46540700
Complication associated with device 16.59 9.70 10 122752 15431 46547869
Septic embolus 16.55 9.70 15 122747 786 46562514
Therapeutic product effect incomplete 16.46 9.70 293 122469 77860 46485440
Upper gastrointestinal haemorrhage 16.42 9.70 12 122750 16726 46546574
Immunodeficiency 16.31 9.70 7 122755 13099 46550201
Drug level decreased 16.30 9.70 43 122719 5869 46557431
Rash pruritic 16.30 9.70 183 122579 44032 46519268
Corneal lesion 16.17 9.70 5 122757 23 46563277
Sinusitis 16.11 9.70 242 122520 129526 46433774
Arrhythmia 16.10 9.70 43 122719 34798 46528502
Dermatomyositis 16.01 9.70 23 122739 1998 46561302
Hyperbilirubinaemia 15.97 9.70 62 122700 10376 46552924
Breast cancer metastatic 15.95 9.70 8 122754 13670 46549630
Portal venous gas 15.89 9.70 6 122756 55 46563245
Treatment noncompliance 15.88 9.70 34 122728 29697 46533603
Transitional cell carcinoma 15.79 9.70 13 122749 598 46562702
Pyelonephritis 15.77 9.70 81 122681 15276 46548024
Haemosiderosis 15.75 9.70 8 122754 157 46563143
Skin lesion removal 15.70 9.70 6 122756 57 46563243
Bronchiectasis 15.64 9.70 57 122705 9259 46554041
Expired product administered 15.61 9.70 41 122721 5581 46557719
Ureteric stenosis 15.53 9.70 13 122749 612 46562688
Renal cancer 15.51 9.70 29 122733 3139 46560161
Myopathy 15.47 9.70 55 122707 8826 46554474
Dry mouth 15.47 9.70 83 122679 54843 46508457
Aspergillus test positive 15.40 9.70 10 122752 317 46562983
Myoglobinuria 15.38 9.70 9 122753 236 46563064
Immunosuppression 15.32 9.70 49 122713 7451 46555849
Caesarean section 15.30 9.70 85 122677 16518 46546782
Reticulocytosis 15.30 9.70 7 122755 108 46563192
Pterygium 15.26 9.70 8 122754 168 46563132
No adverse event 15.26 9.70 43 122719 34188 46529112
Haemorrhage intracranial 15.14 9.70 70 122692 12654 46550646
Natural killer cell count increased 15.08 9.70 4 122758 9 46563291
Cytogenetic abnormality 15.07 9.70 12 122750 526 46562774
Type IIb hyperlipidaemia 15.07 9.70 5 122757 30 46563270
Mucosal ulceration 15.05 9.70 15 122747 886 46562414
Klebsiella sepsis 15 9.70 18 122744 1311 46561989
Metapneumovirus infection 14.91 9.70 14 122748 768 46562532
Chills 14.89 9.70 171 122591 95861 46467439
Pruritus allergic 14.86 9.70 16 122746 1035 46562265
Conjunctival hyperaemia 14.84 9.70 22 122740 1967 46561333
Hypocalcaemia 14.84 9.70 30 122732 26755 46536545
Cystostomy 14.83 9.70 3 122759 0 46563300
Ewing's sarcoma recurrent 14.83 9.70 3 122759 0 46563300
Punctal plug insertion 14.83 9.70 3 122759 0 46563300
Keratosis follicular 14.83 9.70 3 122759 0 46563300
Groin pain 14.83 9.70 55 122707 9010 46554290
Endotracheal intubation 14.81 9.70 23 122739 2142 46561158
Vaginal haemorrhage 14.77 9.70 28 122734 25576 46537724
Transaminases increased 14.71 9.70 124 122638 27637 46535663
Fungal test positive 14.69 9.70 12 122750 546 46562754
Mycobacterium fortuitum infection 14.66 9.70 5 122757 33 46563267
Perinephric collection 14.63 9.70 7 122755 120 46563180
Jejunal ulcer perforation 14.54 9.70 5 122757 34 46563266
Hepatic failure 14.52 9.70 143 122619 33273 46530027
Eyelid pain 14.48 9.70 9 122753 264 46563036
Bronchospasm 14.47 9.70 12 122750 15695 46547605
Moraxella infection 14.45 9.70 10 122752 353 46562947
Blindness cortical 14.43 9.70 11 122751 452 46562848
Infection masked 14.41 9.70 5 122757 35 46563265
Gait inability 14.41 9.70 46 122716 35157 46528143
Nail dystrophy 14.39 9.70 11 122751 454 46562846
Nephrolithiasis 14.38 9.70 42 122720 33009 46530291
Swollen tongue 14.34 9.70 35 122727 29197 46534103
Instillation site dryness 14.26 9.70 4 122758 12 46563288
Genital lesion 14.24 9.70 6 122756 75 46563225
Myelodysplastic syndrome 14.19 9.70 80 122682 15631 46547669
Central nervous system lymphoma 14.18 9.70 17 122745 1237 46562063
Chronic myeloid leukaemia recurrent 14.08 9.70 8 122754 198 46563102
Osteoporotic fracture 14.08 9.70 27 122735 2978 46560322
Still's disease 14.02 9.70 4 122758 13 46563287
Haematochezia 13.98 9.70 51 122711 37442 46525858
Escherichia sepsis 13.97 9.70 33 122729 4205 46559095
Prescribed overdose 13.96 9.70 5 122757 10444 46552856
Eye infection staphylococcal 13.95 9.70 5 122757 39 46563261
Pneumonia herpes viral 13.95 9.70 5 122757 39 46563261
Megakaryocytes increased 13.95 9.70 5 122757 39 46563261
Pericarditis 13.95 9.70 26 122736 23901 46539399
Heart rate irregular 13.93 9.70 17 122745 18574 46544726
Arthritis 13.93 9.70 283 122479 77033 46486267
Device malfunction 13.90 9.70 9 122753 13365 46549935
Serratia infection 13.89 9.70 13 122749 710 46562590
Diabetic macroangiopathy 13.89 9.70 7 122755 135 46563165
CD8 lymphocytes increased 13.80 9.70 4 122758 14 46563286
Pancreas transplant rejection 13.75 9.70 7 122755 138 46563162
White blood cell count decreased 13.69 9.70 210 122552 112021 46451279
Sinus disorder 13.67 9.70 14 122748 16549 46546751
Intervertebral disc degeneration 13.67 9.70 9 122753 13243 46550057
Product quality issue 13.62 9.70 48 122714 35600 46527700
Hypotony of eye 13.62 9.70 7 122755 141 46563159
Corneal abrasion 13.54 9.70 14 122748 864 46562436
Hyperkalaemia 13.53 9.70 78 122684 50631 46512669
CSF protein increased 13.51 9.70 11 122751 498 46562802
Erythrodermic psoriasis 13.40 9.70 14 122748 875 46562425
Candida pneumonia 13.40 9.70 7 122755 146 46563154
Extubation 13.38 9.70 4 122758 16 46563284
Infective chondritis 13.38 9.70 4 122758 16 46563284
Ureteral neoplasm 13.38 9.70 4 122758 16 46563284
Duodenal ulcer perforation 13.33 9.70 3 122759 8499 46554801
Depressed mood 13.32 9.70 44 122718 33275 46530025
Glomerulonephropathy 13.26 9.70 6 122756 90 46563210
Reticulocyte count increased 13.24 9.70 12 122750 629 46562671
Osteoarthritis 13.24 9.70 102 122660 61923 46501377
Mania 13.17 9.70 6 122756 10840 46552460
Tooth infection 13.14 9.70 8 122754 12278 46551022
CD4 lymphocytes increased 13.06 9.70 7 122755 154 46563146
Palmar-plantar erythrodysaesthesia syndrome 13.03 9.70 21 122741 20430 46542870
Lower respiratory tract infection 13.01 9.70 88 122674 55001 46508299
Psychomotor disadaptation syndrome 13.00 9.70 4 122758 18 46563282
IgA nephropathy 12.99 9.70 10 122752 417 46562883
Stevens-Johnson syndrome 12.98 9.70 26 122736 23271 46540029
Therapy cessation 12.97 9.70 32 122730 26597 46536703
Dysmetria 12.97 9.70 9 122753 319 46562981
Hepatic fibrosis 12.93 9.70 26 122736 2969 46560331
Fasciitis 12.92 9.70 11 122751 530 46562770
Cholangitis 12.89 9.70 34 122728 4640 46558660
Eyelid skin dryness 12.86 9.70 5 122757 50 46563250
Hepatic cirrhosis 12.84 9.70 78 122684 15654 46547646
Lymphadenopathy mediastinal 12.82 9.70 23 122739 2411 46560889
Reversible cerebral vasoconstriction syndrome 12.82 9.70 19 122743 1698 46561602
Cutaneous mucormycosis 12.76 9.70 3 122759 3 46563297
Cutaneous malacoplakia 12.76 9.70 3 122759 3 46563297
Megakaryocytes abnormal 12.76 9.70 3 122759 3 46563297
Kidney anastomosis 12.76 9.70 3 122759 3 46563297
Carcinoid tumour of the gastrointestinal tract 12.76 9.70 3 122759 3 46563297
Removal of transplanted organ 12.76 9.70 3 122759 3 46563297
Coxsackie virus test positive 12.76 9.70 3 122759 3 46563297
Squamous cell carcinoma of skin 12.76 9.70 36 122726 5111 46558189
Bronchitis 12.69 9.70 199 122563 105780 46457520
Chronic myeloid leukaemia 12.66 9.70 23 122739 2435 46560865
Skin toxicity 12.65 9.70 29 122733 3625 46559675
Feeling hot 12.61 9.70 54 122708 37874 46525426
Gastroenteritis norovirus 12.61 9.70 18 122744 1555 46561745
Spinal fracture 12.56 9.70 13 122749 15292 46548008
Renal necrosis 12.36 9.70 5 122757 56 46563244
Urinary tract infection 12.36 9.70 464 122298 219802 46343498
Adverse reaction 12.34 9.70 48 122714 8042 46555258
Febrile neutropenia 12.31 9.70 331 122431 94296 46469004
Parenteral nutrition 12.30 9.70 3 122759 4 46563296
Renal haematoma 12.30 9.70 7 122755 174 46563126
Human herpes virus 6 serology positive 12.28 9.70 6 122756 108 46563192
Pneumothorax 12.24 9.70 73 122689 14556 46548744
Alanine aminotransferase abnormal 12.20 9.70 23 122739 2504 46560796
Epidermodysplasia verruciformis 12.20 9.70 5 122757 58 46563242
Tongue pigmentation 12.20 9.70 4 122758 23 46563277
Conjunctival scar 12.20 9.70 4 122758 23 46563277
Choroidal detachment 12.19 9.70 7 122755 177 46563123
Conjunctival oedema 12.18 9.70 11 122751 574 46562726
Toxic encephalopathy 12.15 9.70 35 122727 5027 46558273
Glomerulonephritis proliferative 12.12 9.70 7 122755 179 46563121
Helicobacter infection 12.06 9.70 8 122754 11728 46551572
Lung consolidation 12.06 9.70 29 122733 3738 46559562
Leukodystrophy 12.05 9.70 4 122758 24 46563276
Corneal erosion 12.03 9.70 8 122754 264 46563036
Hyperthyroidism 12.01 9.70 8 122754 11703 46551597
Clonal evolution 11.98 9.70 5 122757 61 46563239
Ciliary body disorder 11.92 9.70 4 122758 25 46563275
Small intestinal obstruction 11.90 9.70 15 122747 16157 46547143
Large intestine polyp 11.88 9.70 3 122759 7858 46555442
Tubulointerstitial nephritis 11.87 9.70 73 122689 14715 46548585
Tooth extraction 11.82 9.70 6 122756 10187 46553113
Toe amputation 11.80 9.70 20 122742 2004 46561296
Ischaemic stroke 11.80 9.70 16 122746 16706 46546594
Dermatitis atopic 11.75 9.70 17 122745 1487 46561813
Metastatic malignant melanoma 11.70 9.70 16 122746 1328 46561972
Cytomegalovirus gastrointestinal infection 11.69 9.70 8 122754 277 46563023
Injection site bruising 11.69 9.70 51 122711 35585 46527715
Cytomegalovirus gastritis 11.68 9.70 7 122755 192 46563108
Eosinophilic pustular folliculitis 11.66 9.70 4 122758 27 46563273
Faecaloma 11.64 9.70 3 122759 7749 46555551
Flatulence 11.63 9.70 38 122724 28840 46534460
Vascular pseudoaneurysm ruptured 11.63 9.70 5 122757 66 46563234
Anogenital warts 11.62 9.70 9 122753 379 46562921
Papilloma viral infection 11.59 9.70 16 122746 1340 46561960
Night sweats 11.58 9.70 35 122727 27215 46536085
Rib fracture 11.58 9.70 20 122742 18934 46544366
Cyanosis 11.56 9.70 15 122747 15956 46547344
Adenoviral encephalitis 11.55 9.70 3 122759 6 46563294
Blood gonadotrophin increased 11.55 9.70 3 122759 6 46563294
Enzyme level increased 11.55 9.70 7 122755 196 46563104
Laboratory test abnormal 11.49 9.70 27 122735 22820 46540480
Obstructive airways disorder 11.45 9.70 11 122751 13401 46549899
Irritable bowel syndrome 11.45 9.70 16 122746 16499 46546801
Respiratory gas exchange disorder 11.45 9.70 9 122753 387 46562913
Muscle twitching 11.44 9.70 13 122749 14659 46548641
Necrosis 11.43 9.70 33 122729 4747 46558553
Vesicoureteric reflux 11.42 9.70 7 122755 200 46563100
Renal vein thrombosis 11.42 9.70 8 122754 288 46563012
Cardiac valve vegetation 11.42 9.70 8 122754 288 46563012
Eating disorder 11.41 9.70 13 122749 14641 46548659
Atypical mycobacterial infection 11.40 9.70 13 122749 897 46562403
Renal tubular disorder 11.37 9.70 22 122740 2443 46560857
Prescribed underdose 11.37 9.70 9 122753 12044 46551256
Genital discomfort 11.36 9.70 5 122757 70 46563230
Lipohypertrophy 11.35 9.70 12 122750 760 46562540
Acute disseminated encephalomyelitis 11.33 9.70 7 122755 203 46563097
Secondary hyperthyroidism 11.29 9.70 4 122758 30 46563270
Vascular graft complication 11.29 9.70 4 122758 30 46563270
Clonic convulsion 11.29 9.70 11 122751 632 46562668
Renal infarct 11.28 9.70 15 122747 1212 46562088
Pyogenic granuloma 11.27 9.70 8 122754 294 46563006
Drug dependence 11.27 9.70 22 122740 19879 46543421
Aqueous humour leakage 11.24 9.70 3 122759 7 46563293
Morphoea 11.20 9.70 8 122754 297 46563003
Diffuse axonal injury 11.18 9.70 4 122758 31 46563269
Ureteric cancer 11.17 9.70 5 122757 73 46563227
Tuberculosis 11.14 9.70 55 122707 10210 46553090
Incorrect dose administered 11.14 9.70 175 122587 45375 46517925
Upper respiratory tract infection 11.13 9.70 110 122652 63446 46499854
Scleroderma 11.11 9.70 32 122730 4597 46558703
Metastases to bone 11.09 9.70 18 122744 17458 46545842
Legionella infection 11.08 9.70 9 122753 406 46562894
Disturbance in attention 11.08 9.70 44 122718 31516 46531784
Pre-eclampsia 11.05 9.70 46 122716 7948 46555352
Mental status changes 11.03 9.70 57 122705 38031 46525269
Ill-defined disorder 11.02 9.70 35 122727 26792 46536508
Cholecystitis chronic 11.00 9.70 7 122755 10492 46552808
Hepatitis C virus test 10.95 9.70 3 122759 8 46563292
Rheumatic disorder 10.95 9.70 16 122746 1412 46561888
Aplasia 10.88 9.70 27 122735 3549 46559751
Anal incontinence 10.85 9.70 9 122753 11769 46551531
Mycoplasma infection 10.82 9.70 9 122753 420 46562880
Device breakage 10.81 9.70 6 122756 9686 46553614
Hepatic haematoma 10.80 9.70 9 122753 421 46562879
Right ventricular failure 10.76 9.70 16 122746 16077 46547223
Plantar fascial fibromatosis 10.73 9.70 6 122756 144 46563156
Apnoea 10.72 9.70 3 122759 7336 46555964
Keratolysis exfoliativa acquired 10.70 9.70 3 122759 9 46563291
Arteriosclerotic retinopathy 10.70 9.70 3 122759 9 46563291
Removal of renal transplant 10.70 9.70 3 122759 9 46563291
Glutamate dehydrogenase level abnormal 10.70 9.70 3 122759 9 46563291
Nightmare 10.62 9.70 17 122745 16581 46546719
Amnesia 10.60 9.70 65 122697 41566 46521734
Injection site induration 10.57 9.70 4 122758 8075 46555225
Meningoradiculitis 10.54 9.70 5 122757 84 46563216
Corneal transplant 10.50 9.70 7 122755 232 46563068
Gliosis 10.50 9.70 7 122755 232 46563068
Congenital musculoskeletal anomaly 10.50 9.70 9 122753 438 46562862
Renal artery thrombosis 10.49 9.70 5 122757 85 46563215
Tanning 10.49 9.70 5 122757 85 46563215
Post procedural urine leak 10.47 9.70 4 122758 38 46563262
Pericardial effusion 10.47 9.70 108 122654 25435 46537865
Pharyngeal necrosis 10.46 9.70 3 122759 10 46563290
Intestinal ulcer perforation 10.46 9.70 3 122759 10 46563290
Liver transplant 10.46 9.70 21 122741 2396 46560904
Capillaritis 10.44 9.70 5 122757 86 46563214
Central venous pressure increased 10.44 9.70 5 122757 86 46563214
Sleep disorder 10.44 9.70 76 122686 46719 46516581
Renal cancer stage IV 10.38 9.70 4 122758 39 46563261
Coeliac disease 10.32 9.70 3 122759 7158 46556142
Pneumonia klebsiella 10.27 9.70 19 122743 2040 46561260
Megakaryocytes decreased 10.24 9.70 3 122759 11 46563289
Acute hepatitis C 10.23 9.70 5 122757 90 46563210
Cholestasis 10.22 9.70 112 122650 26781 46536519
Amniotic cavity infection 10.22 9.70 14 122748 1164 46562136
Respiratory rate increased 10.21 9.70 9 122753 11424 46551876
Urine protein/creatinine ratio increased 10.19 9.70 7 122755 244 46563056
Peritonitis bacterial 10.18 9.70 5 122757 8648 46554652
B-cell lymphoma 10.16 9.70 25 122737 3269 46560031
Cerebral aspergillosis 10.14 9.70 8 122754 346 46562954
Neoplasm malignant 10.12 9.70 30 122732 23469 46539831
Drug level changed 10.09 9.70 6 122756 162 46563138
Dermatitis 10.09 9.70 68 122694 14140 46549160
Injection site reaction 10.06 9.70 79 122683 47770 46515530
Osmotic demyelination syndrome 10.04 9.70 10 122752 590 46562710
Alopecia universalis 10.04 9.70 5 122757 94 46563206
Guillain-Barre syndrome 10.02 9.70 25 122737 3297 46560003
Dysphagia 10 9.70 143 122619 77169 46486131
Cat scratch disease 10.00 9.70 6 122756 165 46563135
Diabetes mellitus inadequate control 9.99 9.70 12 122750 13202 46550098
Haemoglobinuria 9.99 9.70 7 122755 252 46563048
Blood loss anaemia 9.98 9.70 5 122757 8552 46554748
Blood pressure decreased 9.98 9.70 99 122663 57060 46506240
Cutaneous lymphoma 9.96 9.70 6 122756 166 46563134
Hepatomegaly 9.96 9.70 57 122705 11196 46552104
Intracranial pressure increased 9.96 9.70 29 122733 4191 46559109
CSF white blood cell count increased 9.95 9.70 4 122758 44 46563256
Stress cardiomyopathy 9.94 9.70 4 122758 7780 46555520
Shock haemorrhagic 9.93 9.70 47 122715 8577 46554723
Extrapyramidal disorder 9.91 9.70 9 122753 11259 46552041
Injection site warmth 9.90 9.70 13 122749 13759 46549541
Pre-existing condition improved 9.90 9.70 39 122723 6573 46556727
Haemorrhagic cyst 9.87 9.70 6 122756 169 46563131
Meibomian gland dysfunction 9.85 9.70 5 122757 98 46563202
Toxoplasma serology positive 9.84 9.70 3 122759 13 46563287
Diverticulitis 9.82 9.70 49 122713 32990 46530310
Aggression 9.82 9.70 29 122733 22715 46540585
Anger 9.80 9.70 10 122752 11842 46551458
Eyelid sensory disorder 9.79 9.70 4 122758 46 46563254
Red cell distribution width increased 9.77 9.70 4 122758 7700 46555600
Steroid withdrawal syndrome 9.77 9.70 9 122753 482 46562818
Delusion 9.76 9.70 9 122753 11179 46552121
Acid base balance abnormal 9.73 9.70 7 122755 263 46563037
Dyskinesia 9.73 9.70 41 122721 28884 46534416
Vaccination site inflammation 9.72 9.70 4 122758 47 46563253
Vulval cancer stage 0 9.71 9.70 5 122757 101 46563199
Growth of eyelashes 9.71 9.70 6 122756 174 46563126

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 1833.97 10.55 1103 104361 22571 29824443
Graft versus host disease 1316.79 10.55 665 104799 9485 29837529
Acute graft versus host disease 1004.80 10.55 465 104999 5399 29841615
Product use in unapproved indication 858.59 10.55 1172 104292 72521 29774493
Chronic graft versus host disease 820.95 10.55 363 105101 3756 29843258
Acute graft versus host disease in skin 795.21 10.55 365 105099 4151 29842863
Epstein-Barr virus infection 677.84 10.55 372 105092 6334 29840680
Kidney transplant rejection 667.87 10.55 383 105081 7126 29839888
Post transplant lymphoproliferative disorder 628.13 10.55 327 105137 4979 29842035
Graft versus host disease in gastrointestinal tract 597.22 10.55 266 105198 2803 29844211
Posterior reversible encephalopathy syndrome 580.24 10.55 369 105095 8338 29838676
Transplant rejection 530.00 10.55 356 105108 8850 29838164
Nephropathy toxic 479.03 10.55 354 105110 10285 29836729
Graft versus host disease in skin 477 10.55 233 105231 3074 29843940
Acute graft versus host disease in intestine 409.66 10.55 190 105274 2215 29844799
Cystitis haemorrhagic 393.40 10.55 232 105232 4555 29842459
BK virus infection 362.56 10.55 213 105251 4151 29842863
Fatigue 355.85 10.55 364 105100 320309 29526705
Thrombotic microangiopathy 346.64 10.55 268 105196 8342 29838672
Blood creatinine increased 337.82 10.55 889 104575 90486 29756528
Complications of transplanted kidney 324.58 10.55 194 105270 3907 29843107
Epstein-Barr virus associated lymphoproliferative disorder 320.97 10.55 145 105319 1583 29845431
Completed suicide 312.64 10.55 8 105456 99484 29747530
Renal impairment 310.06 10.55 818 104646 83366 29763648
Immunosuppressant drug level increased 270.99 10.55 182 105282 4520 29842494
Dizziness 270.66 10.55 177 105287 194732 29652282
Drug abuse 268.25 10.55 4 105460 82068 29764946
Fall 260.97 10.55 159 105305 181713 29665301
Aspergillus infection 251.71 10.55 240 105224 9974 29837040
Heart transplant rejection 248.25 10.55 110 105354 1143 29845871
Bronchopulmonary aspergillosis 240.89 10.55 255 105209 12029 29834985
Adenovirus infection 235.94 10.55 161 105303 4107 29842907
Chronic graft versus host disease in skin 230.27 10.55 89 105375 631 29846383
Death 229.58 10.55 582 104882 356701 29490313
Pneumonia cytomegaloviral 223.17 10.55 133 105331 2663 29844351
Gingival hypertrophy 220.45 10.55 110 105354 1523 29845491
Acute graft versus host disease in liver 216.47 10.55 100 105364 1154 29845860
Hepatic function abnormal 215.34 10.55 464 105000 41481 29805533
Liver transplant rejection 211.27 10.55 118 105346 2080 29844934
Haemophagocytic lymphohistiocytosis 207.69 10.55 212 105252 9579 29837435
Cytomegalovirus test positive 205.06 10.55 139 105325 3506 29843508
Cytomegalovirus viraemia 199.94 10.55 164 105300 5565 29841449
Multiple organ dysfunction syndrome 189.54 10.55 572 104892 62915 29784099
Hypotension 187.35 10.55 260 105204 200305 29646709
Graft versus host disease in liver 182.68 10.55 83 105381 919 29846095
Proteinuria 174.34 10.55 248 105216 15897 29831117
Chronic allograft nephropathy 173.69 10.55 84 105380 1082 29845932
Immunosuppressant drug level decreased 173.48 10.55 86 105378 1173 29845841
Transplant failure 171.46 10.55 108 105356 2396 29844618
Nephrotic syndrome 170.05 10.55 162 105302 6723 29840291
Eye irritation 169.94 10.55 149 105315 5547 29841467
Obliterative bronchiolitis 168.54 10.55 83 105381 1115 29845899
Drug eruption 167.27 10.55 254 105210 17272 29829742
Pyrexia 164.72 10.55 1670 103794 292819 29554195
Mucormycosis 161.59 10.55 140 105324 5128 29841886
Syncope 159.83 10.55 50 105414 84853 29762161
Polyomavirus viraemia 159.16 10.55 62 105402 450 29846564
Dyspnoea 153.06 10.55 630 104834 332665 29514349
Transplant dysfunction 152.47 10.55 98 105366 2254 29844760
Polyomavirus-associated nephropathy 152.42 10.55 110 105354 3075 29843939
Asthenia 149.95 10.55 350 105114 220940 29626074
Squamous cell carcinoma 143.83 10.55 179 105285 10071 29836943
Product dose omission issue 141.45 10.55 73 105391 91558 29755456
Lymphoproliferative disorder 141.04 10.55 93 105371 2237 29844777
Venoocclusive disease 136.78 10.55 95 105369 2495 29844519
Aplastic anaemia 135.83 10.55 130 105334 5426 29841588
Constipation 135.38 10.55 119 105345 112787 29734227
Drug ineffective 133.97 10.55 1804 103660 338583 29508431
Anxiety 129.48 10.55 78 105386 89793 29757221
Kidney fibrosis 128.10 10.55 84 105380 2001 29845013
Intentional overdose 127.76 10.55 4 105460 41477 29805537
Lymphocele 125.85 10.55 73 105391 1387 29845627
Cytomegalovirus infection reactivation 125.08 10.55 77 105387 1638 29845376
Cardiac failure congestive 121.95 10.55 73 105391 84334 29762680
Overdose 121.77 10.55 73 105391 84264 29762750
Stomatitis 119.87 10.55 345 105119 36934 29810080
Disease recurrence 119.53 10.55 194 105270 13967 29833047
Chronic graft versus host disease in intestine 119.01 10.55 41 105423 199 29846815
Psoriasis 118.43 10.55 374 105090 42132 29804882
Pain 116.87 10.55 273 105191 172368 29674646
Oral administration complication 115.65 10.55 32 105432 59 29846955
Human herpesvirus 6 infection 113.32 10.55 76 105388 1882 29845132
Focal segmental glomerulosclerosis 113.21 10.55 74 105390 1753 29845261
Myocardial infarction 113.02 10.55 167 105297 125458 29721556
Pneumocystis jirovecii pneumonia 112.49 10.55 210 105254 16910 29830104
JC virus infection 109.69 10.55 72 105392 1718 29845296
Somnolence 108.88 10.55 108 105356 96655 29750359
Lung transplant rejection 107.16 10.55 53 105411 719 29846295
Cerebrovascular accident 106.19 10.55 83 105381 83394 29763620
Complications of bone marrow transplant 106.18 10.55 37 105427 187 29846827
Hyperhidrosis 102.69 10.55 54 105410 67036 29779978
Viraemia 99.11 10.55 58 105406 1121 29845893
Decreased appetite 99.08 10.55 240 105224 149670 29697344
Chest pain 96.69 10.55 166 105298 117461 29729553
Dehydration 95.59 10.55 181 105283 123358 29723656
Renal transplant failure 94.46 10.55 54 105410 997 29846017
Hepatitis E 93.62 10.55 63 105401 1569 29845445
Depression 91.72 10.55 110 105354 90327 29756687
Chronic graft versus host disease in liver 91.17 10.55 35 105429 243 29846771
Venoocclusive liver disease 90.40 10.55 114 105350 6499 29840515
Bradycardia 90.05 10.55 60 105404 65466 29781548
Chronic obstructive pulmonary disease 88.87 10.55 26 105438 46100 29800914
Kaposi's sarcoma 87.55 10.55 51 105413 977 29846037
Back pain 85.03 10.55 144 105320 102452 29744562
Mucosal inflammation 84.63 10.55 268 105196 30226 29816788
Graft loss 84.41 10.55 47 105417 823 29846191
Progressive multifocal leukoencephalopathy 83.69 10.55 129 105335 8884 29838130
Confusional state 82.05 10.55 225 105239 134609 29712405
Suicide attempt 81.97 10.55 15 105449 36682 29810332
Hypoglycaemia 81.06 10.55 39 105425 50942 29796072
Vein rupture 80.82 10.55 41 105423 589 29846425
Neurotoxicity 79.58 10.55 156 105308 13026 29833988
Herpes simplex 79.33 10.55 88 105376 4376 29842638
Atrial fibrillation 78.82 10.55 164 105300 107960 29739054
Rash 78.54 10.55 378 105086 191511 29655503
Agitation 77.74 10.55 47 105417 54026 29792988
Tenosynovitis 76.15 10.55 77 105387 3438 29843576
Suicidal ideation 76.01 10.55 17 105447 36097 29810917
Hirsutism 75.53 10.55 27 105437 149 29846865
Engraftment syndrome 75.40 10.55 43 105421 790 29846224
Cardiac arrest 75.39 10.55 132 105332 92718 29754296
Malaise 74.21 10.55 319 105145 166643 29680371
International normalised ratio increased 73.67 10.55 38 105426 47701 29799313
Haemodialysis 72.95 10.55 136 105328 10937 29836077
Drug resistance 71.26 10.55 193 105271 19940 29827074
Enterococcal infection 71.22 10.55 114 105350 8110 29838904
Enthesopathy 71.04 10.55 68 105396 2838 29844176
Aggression 70.73 10.55 21 105443 36886 29810128
Acute myocardial infarction 70.70 10.55 50 105414 52889 29794125
Graft versus host disease in eye 69.66 10.55 27 105437 193 29846821
Pulmonary embolism 69.12 10.55 105 105359 78030 29768984
Aplasia pure red cell 69.11 10.55 92 105372 5534 29841480
Engraft failure 68.58 10.55 33 105431 420 29846594
Acute myeloid leukaemia recurrent 68.38 10.55 51 105413 1501 29845513
Renal tubular atrophy 68.22 10.55 44 105420 1018 29845996
Skin plaque 68.21 10.55 74 105390 3588 29843426
Pseudomonas infection 68.13 10.55 128 105336 10354 29836660
Rheumatoid arthritis 67.84 10.55 30 105434 41167 29805847
Graft versus host disease in lung 67.67 10.55 34 105430 478 29846536
Insomnia 67.65 10.55 142 105322 93194 29753820
Electrocardiogram QT prolonged 67.57 10.55 21 105443 35814 29811200
Fungal infection 66.94 10.55 148 105316 13452 29833562
Cardio-respiratory arrest 66.71 10.55 62 105402 57244 29789770
Injection site pain 66.40 10.55 13 105451 30297 29816717
Stem cell transplant 66.09 10.55 57 105407 2074 29844940
Therapy non-responder 66.02 10.55 241 105223 29212 29817802
Balance disorder 65.98 10.55 23 105441 36470 29810544
Leukaemia recurrent 65.90 10.55 50 105414 1511 29845503
Glomerulonephritis membranous 65.58 10.55 43 105421 1024 29845990
Haemolytic uraemic syndrome 65.05 10.55 55 105409 1947 29845067
Malignant neoplasm progression 65.04 10.55 96 105368 72191 29774823
Unevaluable event 64.84 10.55 16 105448 31769 29815245
Hospitalisation 64.44 10.55 38 105426 44281 29802733
Peripheral swelling 64.36 10.55 72 105392 61002 29786012
Hyponatraemia 63.69 10.55 86 105378 67116 29779898
Haemolysis 63.66 10.55 101 105363 7130 29839884
Concomitant disease progression 63.57 10.55 60 105404 2460 29844554
Nausea 63.28 10.55 705 104759 296252 29550762
Weight decreased 63.05 10.55 295 105169 150626 29696388
End stage renal disease 62.93 10.55 102 105362 7333 29839681
Erythrodermic psoriasis 62.78 10.55 37 105427 725 29846289
Coombs positive haemolytic anaemia 62.64 10.55 37 105427 728 29846286
Cytomegalovirus chorioretinitis 62.56 10.55 67 105397 3201 29843813
Blood bilirubin increased 62.27 10.55 275 105189 36361 29810653
Joint swelling 61.82 10.55 45 105419 46901 29800113
Diffuse large B-cell lymphoma 61.57 10.55 104 105360 7737 29839277
Pneumonia fungal 61.20 10.55 86 105378 5447 29841567
Plasma cell myeloma 60.87 10.55 59 105405 53403 29793611
Hypogammaglobulinaemia 60.14 10.55 83 105381 5169 29841845
Complications of transplanted heart 59.74 10.55 25 105439 223 29846791
Neuropathy peripheral 59.21 10.55 98 105366 70377 29776637
Toxoplasmosis 59.20 10.55 40 105424 1003 29846011
Behcet's syndrome 58.50 10.55 18 105446 56 29846958
Nephrectomy 58.38 10.55 34 105430 651 29846363
Rectal haemorrhage 58.23 10.55 25 105439 34914 29812100
Chorioretinopathy 57.99 10.55 45 105419 1407 29845607
Pustular psoriasis 57.45 10.55 47 105417 1588 29845426
Thrombotic thrombocytopenic purpura 56.57 10.55 65 105399 3360 29843654
Loss of consciousness 56.47 10.55 122 105342 79253 29767761
Hypokalaemia 56.44 10.55 56 105408 50136 29796878
Weight increased 55.94 10.55 112 105352 74801 29772213
Cystitis viral 55.88 10.55 29 105435 438 29846576
Renal tubular necrosis 55.79 10.55 148 105316 15103 29831911
Viral test positive 55.17 10.55 23 105441 203 29846811
Hypersensitivity 54.97 10.55 352 105112 53676 29793338
Spermatozoa progressive motility decreased 54.70 10.55 20 105444 119 29846895
Intentional product misuse 54.37 10.55 27 105437 34640 29812374
Skin lesion 53.57 10.55 165 105299 18329 29828685
Ureteric stenosis 53.23 10.55 40 105424 1191 29845823
Human herpesvirus 8 infection 52.97 10.55 32 105432 657 29846357
Squamous cell carcinoma of skin 52.93 10.55 106 105358 8989 29838025
Toxicity to various agents 52.82 10.55 386 105078 176797 29670217
Asthma 52.61 10.55 31 105433 36143 29810871
Cutaneous T-cell lymphoma 52.51 10.55 41 105423 1294 29845720
Bacterial sepsis 52.18 10.55 75 105389 4851 29842163
Treatment failure 52.05 10.55 251 105213 34428 29812586
Drug withdrawal syndrome 51.59 10.55 5 105459 19804 29827210
Serotonin syndrome 50.88 10.55 3 105461 17888 29829126
Alternaria infection 50.75 10.55 24 105440 293 29846721
Staphylococcal infection 50.70 10.55 226 105238 29998 29817016
Hallucination 50.42 10.55 59 105405 49000 29798014
American trypanosomiasis 49.92 10.55 21 105443 190 29846824
Vomiting 49.91 10.55 514 104950 219304 29627710
Renal transplant 49.81 10.55 45 105419 1743 29845271
Hypertrichosis 49.74 10.55 23 105441 266 29846748
Diarrhoea 49.70 10.55 853 104611 333250 29513764
Cytomegalovirus colitis 49.51 10.55 51 105413 2328 29844686
Mycobacterial infection 49.30 10.55 44 105420 1677 29845337
Disseminated tuberculosis 49.15 10.55 48 105416 2054 29844960
Blood glucose increased 48.55 10.55 89 105375 61441 29785573
Pyogenic granuloma 48.53 10.55 21 105443 205 29846809
Drug reaction with eosinophilia and systemic symptoms 48.09 10.55 20 105444 28468 29818546
Basal cell carcinoma 48.08 10.55 145 105319 15923 29831091
Lactic acidosis 47.92 10.55 25 105439 31188 29815826
Venous injury 47.84 10.55 22 105442 251 29846763
Pneumomediastinum 47.79 10.55 44 105420 1747 29845267
Flushing 47.73 10.55 22 105442 29470 29817544
Coronary artery disease 47.72 10.55 63 105401 49649 29797365
Osteonecrosis of jaw 47.71 10.55 5 105459 18613 29828401
Complications of transplant surgery 47.59 10.55 27 105437 491 29846523
Chest discomfort 47.49 10.55 54 105410 45426 29801588
Sepsis 47.36 10.55 751 104713 145644 29701370
Blood beta-D-glucan increased 46.91 10.55 26 105438 451 29846563
Blood stem cell transplant failure 46.89 10.55 25 105439 400 29846614
Hypertension 46.47 10.55 641 104823 120713 29726301
Autoimmune haemolytic anaemia 46.25 10.55 64 105400 3995 29843019
Lung infiltration 45.05 10.55 121 105343 12438 29834576
Pruritus 44.78 10.55 239 105225 117965 29729049
Sebaceous hyperplasia 44.70 10.55 14 105450 47 29846967
Epstein-Barr viraemia 44.66 10.55 32 105432 884 29846130
Tongue disorder 44.60 10.55 65 105399 4257 29842757
Scedosporium infection 44.40 10.55 29 105435 686 29846328
Cardiac disorder 44.29 10.55 45 105419 39848 29807166
Viral haemorrhagic cystitis 44.11 10.55 31 105433 830 29846184
Feeling abnormal 43.98 10.55 83 105381 56673 29790341
Serum sickness 43.97 10.55 42 105422 1748 29845266
Mycoplasma infection 43.73 10.55 21 105443 266 29846748
Biopsy kidney abnormal 43.51 10.55 16 105448 97 29846917
Blood lactate dehydrogenase increased 43.18 10.55 165 105299 20436 29826578
Glomerulosclerosis 43.18 10.55 28 105436 654 29846360
Dyspepsia 42.69 10.55 27 105437 30302 29816712
Escherichia infection 42.60 10.55 79 105385 6326 29840688
Haptoglobin decreased 42.44 10.55 26 105438 548 29846466
Encephalitis 42.33 10.55 79 105385 6357 29840657
Deep vein thrombosis 42.19 10.55 94 105370 60407 29786607
Encephalitis cytomegalovirus 42.17 10.55 23 105441 386 29846628
Candida infection 41.68 10.55 134 105330 15228 29831786
Wheezing 41.58 10.55 29 105435 30909 29816105
Trichophytic granuloma 41.31 10.55 14 105450 64 29846950
Drug level increased 40.96 10.55 150 105314 18204 29828810
Bacterial infection 40.79 10.55 117 105347 12493 29834521
Cushingoid 40.74 10.55 47 105417 2440 29844574
Lymphadenopathy 40.67 10.55 182 105282 24194 29822820
Psoriatic arthropathy 40.54 10.55 135 105329 15626 29831388
Sedation 40.44 10.55 5 105459 16368 29830646
Oliguria 40.10 10.55 84 105380 7355 29839659
Cryptococcosis 40.00 10.55 40 105424 1762 29845252
Alveolar proteinosis 39.94 10.55 20 105444 279 29846735
Drug level changed 39.78 10.55 21 105443 329 29846685
Wrong technique in product usage process 39.55 10.55 31 105433 31124 29815890
Arthralgia 39.39 10.55 298 105166 135493 29711521
Rhabdomyolysis 39.37 10.55 369 105095 63211 29783803
Erythema infectiosum 39.37 10.55 17 105447 165 29846849
Erectile dysfunction 39.15 10.55 8 105456 18094 29828920
Cytomegalovirus syndrome 38.97 10.55 15 105449 105 29846909
Red blood cell schistocytes present 38.66 10.55 20 105444 300 29846714
Delirium 38.48 10.55 52 105412 40579 29806435
Laparotomy 38.40 10.55 19 105445 258 29846756
Acute respiratory distress syndrome 38.23 10.55 174 105290 23298 29823716
Abdominal discomfort 38.11 10.55 71 105393 48720 29798294
Glomerulonephritis 37.97 10.55 39 105425 1774 29845240
Adenoviral haemorrhagic cystitis 37.92 10.55 22 105442 418 29846596
Lymphadenitis 37.85 10.55 38 105426 1682 29845332
Urinary retention 37.84 10.55 36 105428 32881 29814133
Drug hypersensitivity 37.52 10.55 120 105344 68399 29778615
Nocardiosis 37.17 10.55 53 105411 3402 29843612
Alanine aminotransferase abnormal 37.15 10.55 46 105418 2573 29844441
Therapeutic response decreased 37.08 10.55 177 105287 24172 29822842
Cerebral toxoplasmosis 37.04 10.55 35 105429 1437 29845577
Brain stem syndrome 37.01 10.55 21 105443 382 29846632
Urticaria 36.91 10.55 323 105141 54283 29792731
Staphylococcal sepsis 36.65 10.55 94 105370 9397 29837617
Hypoaesthesia 36.40 10.55 86 105378 54144 29792870
Gastrooesophageal reflux disease 36.24 10.55 36 105428 32219 29814795
Renal lymphocele 35.93 10.55 12 105452 52 29846962
Plasmablastic lymphoma 35.89 10.55 18 105446 252 29846762
Epstein-Barr virus associated lymphoma 35.85 10.55 23 105441 527 29846487
Gait disturbance 35.57 10.55 139 105325 74638 29772376
Instillation site pain 35.55 10.55 14 105450 105 29846909
Skin mass 35.40 10.55 52 105412 3430 29843584
Ventricular tachycardia 35.33 10.55 20 105444 23842 29823172
Encephalitis fungal 35.30 10.55 16 105448 176 29846838
Systemic candida 35.19 10.55 46 105418 2718 29844296
Diabetes mellitus 35.01 10.55 260 105204 41605 29805409
Herpes virus infection 35.00 10.55 44 105420 2500 29844514
Acute lymphocytic leukaemia recurrent 34.91 10.55 45 105419 2622 29844392
Palpitations 34.90 10.55 40 105424 33533 29813481
Atypical mycobacterial pneumonia 34.88 10.55 14 105450 111 29846903
Brain abscess 34.72 10.55 45 105419 2636 29844378
Injection site erythema 34.72 10.55 4 105460 13830 29833184
Glomerulonephritis membranoproliferative 34.66 10.55 20 105444 376 29846638
Tularaemia 34.39 10.55 13 105451 86 29846928
Bacillary angiomatosis 34.38 10.55 12 105452 61 29846953
Mechanical ventilation 34.33 10.55 36 105428 1678 29845336
Lymphocytic infiltration 34.31 10.55 23 105441 569 29846445
Urine output decreased 34.16 10.55 93 105371 9636 29837378
Pancytopenia 34.07 10.55 453 105011 84599 29762415
Cytomegalovirus hepatitis 33.49 10.55 18 105446 293 29846721
Myopathy toxic 33.39 10.55 20 105444 404 29846610
Injection site papule 33.33 10.55 18 105446 296 29846718
Skin papilloma 33.23 10.55 35 105429 1640 29845374
Cat scratch disease 33.16 10.55 12 105452 69 29846945
Meningoencephalitis herpetic 33.02 10.55 25 105439 753 29846261
Mass excision 33.02 10.55 10 105454 29 29846985
Renal failure 32.86 10.55 637 104827 128329 29718685
Drug dependence 32.77 10.55 17 105447 21278 29825736
Endoscopic retrograde cholangiopancreatography 32.77 10.55 8 105456 6 29847008
Escherichia sepsis 32.72 10.55 54 105410 3940 29843074
Toxic leukoencephalopathy 32.68 10.55 16 105448 212 29846802
Actinic keratosis 32.65 10.55 51 105413 3552 29843462
Nephropathy 32.57 10.55 64 105400 5352 29841662
Post transplant distal limb syndrome 32.39 10.55 17 105447 263 29846751
Leukopenia 32.33 10.55 321 105143 55838 29791176
Life support 32.32 10.55 14 105450 137 29846877
C-reactive protein abnormal 32.32 10.55 65 105399 5528 29841486
Tachycardia 32.01 10.55 142 105322 73597 29773417
Abnormal behaviour 31.89 10.55 26 105438 25597 29821417
Memory impairment 31.85 10.55 51 105413 37123 29809891
Hydronephrosis 31.67 10.55 86 105378 8897 29838117
Orthostatic hypotension 31.54 10.55 23 105441 23956 29823058
Respiratory arrest 31.35 10.55 34 105430 29224 29817790
Myopathy 31.17 10.55 95 105369 10491 29836523
Dysgeusia 31.08 10.55 25 105439 24776 29822238
Foreign body sensation in eyes 31.03 10.55 21 105443 528 29846486
Growth retardation 30.97 10.55 33 105431 1567 29845447
Nasopharyngitis 30.88 10.55 105 105359 58744 29788270
Renal vessel disorder 30.87 10.55 16 105448 241 29846773
Hepatitis B reactivation 30.76 10.55 44 105420 2833 29844181
Hypertensive encephalopathy 30.53 10.55 18 105446 353 29846661
Apoptosis 30.49 10.55 15 105449 201 29846813
B-cell lymphoma 30.46 10.55 56 105408 4454 29842560
Lung lobectomy 30.34 10.55 8 105456 11 29847003
Eye pain 30.34 10.55 101 105363 11688 29835326
Head injury 30.29 10.55 11 105453 17009 29830005
Hypocalcaemia 30.13 10.55 19 105445 21357 29825657
Renal disorder 30.00 10.55 163 105301 23421 29823593
Dyskinesia 29.96 10.55 20 105444 21814 29825200
Anaemia 29.87 10.55 534 104930 207458 29639556
Anuria 29.84 10.55 92 105372 10224 29836790
Contusion 29.65 10.55 40 105424 31240 29815774
Bone marrow failure 29.63 10.55 193 105271 29592 29817422
Epstein-Barr virus antibody positive 29.59 10.55 17 105447 317 29846697
Mycobacterium kansasii infection 29.35 10.55 15 105449 219 29846795
Acinetobacter infection 29.28 10.55 26 105438 984 29846030
Blood urea increased 29.20 10.55 200 105264 31181 29815833
Paraesthesia 29.15 10.55 96 105368 54231 29792783
Musculoskeletal stiffness 29.10 10.55 51 105413 35830 29811184
Unresponsive to stimuli 29.09 10.55 30 105434 26389 29820625
Hypersomnia 29.09 10.55 3 105461 11313 29835701
Bone marrow transplant rejection 29.04 10.55 14 105450 179 29846835
Diabetic ketoacidosis 29.02 10.55 10 105454 15976 29831038
Pyelonephritis chronic 29.01 10.55 9 105455 29 29846985
Removal of renal transplant 29.01 10.55 9 105455 29 29846985
Legionella infection 28.94 10.55 18 105446 390 29846624
Hyperplasia 28.93 10.55 20 105444 521 29846493
Bacteraemia 28.89 10.55 120 105344 15440 29831574
Serum ferritin increased 28.84 10.55 61 105403 5376 29841638
Hepatitis C 28.70 10.55 107 105357 13098 29833916
Immunosuppression 28.55 10.55 59 105405 5116 29841898
Central nervous system lesion 28.33 10.55 57 105407 4849 29842165
Sweat gland tumour 28.19 10.55 18 105446 409 29846605
Hepatic cancer recurrent 28.14 10.55 17 105447 349 29846665
Dermatitis atopic 28.12 10.55 26 105438 1038 29845976
Fungal sepsis 28.05 10.55 22 105442 699 29846315
Enterococcal sepsis 28.01 10.55 31 105433 1537 29845477
Blindness cortical 28.01 10.55 16 105448 295 29846719
Human polyomavirus infection 27.84 10.55 21 105443 629 29846385
Renal arteriosclerosis 27.76 10.55 13 105451 155 29846859
Phaeohyphomycosis 27.67 10.55 23 105441 795 29846219
Product quality issue 27.42 10.55 16 105448 18758 29828256
Candida sepsis 27.40 10.55 26 105438 1073 29845941
Klebsiella sepsis 27.37 10.55 32 105432 1685 29845329
Drug level decreased 27.25 10.55 62 105402 5743 29841271
Opportunistic infection 27.22 10.55 28 105436 1276 29845738
Adverse event 27.16 10.55 10 105454 15331 29831683
Aplasia 27.11 10.55 50 105414 3987 29843027
Systemic mycosis 27.01 10.55 27 105437 1189 29845825
Osmotic demyelination syndrome 26.83 10.55 21 105443 665 29846349
Scleroderma 26.81 10.55 28 105436 1299 29845715
Smooth muscle cell neoplasm 26.79 10.55 11 105453 93 29846921
Neuroendocrine carcinoma of the skin 26.63 10.55 20 105444 595 29846419
Reticulocyte count increased 26.58 10.55 18 105446 453 29846561
Acute disseminated encephalomyelitis 26.48 10.55 10 105454 66 29846948
Treatment noncompliance 26.34 10.55 30 105434 25223 29821791
Uveitis 26.27 10.55 59 105405 5418 29841596
C-reactive protein increased 26.25 10.55 251 105213 43222 29803792
Transient ischaemic attack 26.22 10.55 30 105434 25170 29821844
Fusarium infection 26.20 10.55 25 105439 1039 29845975
Leukoencephalopathy 26.16 10.55 49 105415 3953 29843061
Complications of transplanted liver 26.10 10.55 14 105450 227 29846787
Thrombosis 25.99 10.55 70 105394 42161 29804853
Injury 25.88 10.55 23 105441 21708 29825306
Steroid diabetes 25.83 10.55 27 105437 1254 29845760
Adverse drug reaction 25.81 10.55 26 105438 23119 29823895
Eosinophilia 25.74 10.55 24 105440 22136 29824878
Trichophytosis 25.58 10.55 15 105449 291 29846723
Bowen's disease 25.56 10.55 12 105452 144 29846870
Heart rate increased 25.51 10.55 62 105402 38659 29808355
Encephalitis viral 25.47 10.55 26 105438 1174 29845840
Pneumonia pseudomonal 25.44 10.55 45 105419 3473 29843541
Hepatitis B 25.40 10.55 62 105402 6010 29841004
Klebsiella infection 25.35 10.55 67 105397 6820 29840194
Pneumonia aspiration 25.28 10.55 60 105404 37720 29809294
Papilloma viral infection 25.16 10.55 16 105448 361 29846653
Pneumonia adenoviral 25.06 10.55 12 105452 151 29846863
Pain in jaw 25.02 10.55 6 105458 12150 29834864
Incisional drainage 24.93 10.55 11 105453 113 29846901
Laser therapy 24.86 10.55 6 105458 4 29847010
Infective tenosynovitis 24.83 10.55 9 105455 52 29846962
CSF protein increased 24.75 10.55 21 105443 747 29846267
Porokeratosis 24.73 10.55 10 105454 81 29846933
Dysphagia 24.71 10.55 109 105355 56589 29790425
Lethargy 24.70 10.55 65 105399 39454 29807560
Blood potassium decreased 24.62 10.55 14 105450 16648 29830366
Stress 24.61 10.55 21 105443 20214 29826800
Prostatic specific antigen increased 24.56 10.55 6 105458 11998 29835016
Lepromatous leprosy 24.52 10.55 10 105454 83 29846931
Incorrect route of product administration 24.47 10.55 5 105459 11310 29835704
Papilloma 24.35 10.55 11 105453 120 29846894
Glomerulonephritis proliferative 24.33 10.55 13 105451 209 29846805
Road traffic accident 24.30 10.55 15 105449 17056 29829958
Endotracheal intubation 24.06 10.55 36 105428 2414 29844600
Gastroenteritis rotavirus 23.93 10.55 12 105452 168 29846846
Papule 23.86 10.55 41 105423 3092 29843922
Haematotoxicity 23.71 10.55 61 105403 6109 29840905
Disseminated cryptococcosis 23.51 10.55 23 105441 986 29846028
Vertigo 23.49 10.55 27 105437 22608 29824406
Swelling face 23.44 10.55 24 105440 21180 29825834
Blood pressure decreased 23.35 10.55 86 105378 46989 29800025
Lymphopenia 23.26 10.55 100 105364 13063 29833951
Complications of transplanted lung 23.25 10.55 12 105452 179 29846835
Bronchitis 23.22 10.55 66 105398 39059 29807955
Oesophageal squamous cell carcinoma 23.14 10.55 15 105449 350 29846664
Hyperkeratosis 23.08 10.55 42 105422 3315 29843699
Fungal test positive 23.04 10.55 17 105447 492 29846522
Refractoriness to platelet transfusion 23.03 10.55 8 105456 40 29846974
Presyncope 23.00 10.55 14 105450 16042 29830972
Squamous cell carcinoma of the tongue 22.90 10.55 12 105452 185 29846829
Ureaplasma infection 22.90 10.55 12 105452 185 29846829
Nightmare 22.90 10.55 7 105457 12069 29834945
Pneumatosis intestinalis 22.89 10.55 37 105427 2653 29844361
Dry eye 22.88 10.55 62 105402 6406 29840608
Infection in an immunocompromised host 22.85 10.55 19 105445 657 29846357
Abdominal pain upper 22.82 10.55 128 105336 62423 29784591
West Nile viral infection 22.65 10.55 18 105446 583 29846431
Respiratory failure 22.60 10.55 488 104976 100154 29746860
Laboratory test abnormal 22.59 10.55 17 105447 17425 29829589
IgA nephropathy 22.55 10.55 22 105442 940 29846074
Tremor 22.49 10.55 164 105300 75199 29771815
Cerebral fungal infection 22.45 10.55 12 105452 193 29846821
Irritability 22.33 10.55 29 105435 23021 29823993
Nodule 22.32 10.55 51 105413 4737 29842277
Skin laceration 22.30 10.55 6 105458 11245 29835769
General physical health deterioration 22.08 10.55 235 105229 99709 29747305
Drug level fluctuating 22.08 10.55 16 105448 450 29846564
Macule 22.02 10.55 21 105443 872 29846142
Coma 22.02 10.55 71 105393 40378 29806636
Central nervous system fungal infection 22.00 10.55 13 105451 256 29846758
Human ehrlichiosis 21.97 10.55 12 105452 202 29846812
Wound dehiscence 21.96 10.55 41 105423 3300 29843714
Synovitis 21.87 10.55 80 105384 9703 29837311
Rotavirus infection 21.85 10.55 14 105450 320 29846694
Flatulence 21.82 10.55 19 105445 18110 29828904
Sinus bradycardia 21.78 10.55 7 105457 11688 29835326
Cytomegalovirus enteritis 21.76 10.55 15 105449 389 29846625
Musculoskeletal pain 21.62 10.55 48 105416 30892 29816122
Achromobacter infection 21.55 10.55 8 105456 50 29846964
Haemorrhagic cyst 21.55 10.55 8 105456 50 29846964
Oligospermia 21.53 10.55 9 105455 80 29846934
Subdural haematoma 21.51 10.55 21 105443 18951 29828063
Glomerulonephritis minimal lesion 21.43 10.55 15 105449 399 29846615
Toxic encephalopathy 21.38 10.55 49 105415 4560 29842454
Hepatosplenomegaly 21.37 10.55 43 105421 3658 29843356
Chronic myeloid leukaemia 21.33 10.55 35 105429 2542 29844472
Neoplasm skin 21.30 10.55 16 105448 476 29846538
Low birth weight baby 21.25 10.55 58 105406 6018 29840996
Respiratory depression 21.22 10.55 7 105457 11496 29835518
Herpes zoster 21.21 10.55 179 105285 29764 29817250
CSF cell count increased 21.21 10.55 7 105457 29 29846985
Pulmonary haemorrhage 21.16 10.55 77 105387 9315 29837699
Cryptococcal cutaneous infection 21.15 10.55 9 105455 84 29846930
Idiopathic intracranial hypertension 21.12 10.55 17 105447 561 29846453
Epistaxis 21.12 10.55 282 105182 52699 29794315
Swollen tongue 21.10 10.55 10 105454 13182 29833832
Drug ineffective for unapproved indication 21.06 10.55 85 105379 10795 29836219
Fear 21.03 10.55 6 105458 10819 29836195
Hair follicle tumour benign 20.92 10.55 5 105459 3 29847011
Perinephric collection 20.91 10.55 11 105453 171 29846843
Scleral hyperaemia 20.91 10.55 8 105456 55 29846959
Small intestinal obstruction 20.87 10.55 11 105453 13648 29833366
Varicella zoster virus infection 20.83 10.55 24 105440 1244 29845770
Diffuse large B-cell lymphoma stage IV 20.78 10.55 12 105452 226 29846788
Pulmonary tuberculosis 20.75 10.55 50 105414 4807 29842207
Poikiloderma 20.74 10.55 11 105453 174 29846840
Cytomegalovirus gastrointestinal infection 20.73 10.55 10 105454 128 29846886
Gouty tophus 20.73 10.55 10 105454 128 29846886
Arterial disorder 20.71 10.55 23 105441 1145 29845869
Retinitis 20.69 10.55 13 105451 287 29846727
Pyoderma gangrenosum 20.61 10.55 22 105442 1047 29845967
Respiratory syncytial virus infection 20.50 10.55 40 105424 3328 29843686
Microsporidia infection 20.47 10.55 17 105447 587 29846427
Angina pectoris 20.46 10.55 46 105418 29472 29817542
Mycobacterium chelonae infection 20.44 10.55 17 105447 588 29846426
Varicella 20.32 10.55 26 105438 1504 29845510
Meningeal neoplasm 20.31 10.55 8 105456 60 29846954
Haematoma evacuation 20.25 10.55 11 105453 183 29846831
Tumour lysis syndrome 20.25 10.55 10 105454 12875 29834139
Cholangitis 20.21 10.55 67 105397 7735 29839279
Cytogenetic abnormality 20.21 10.55 19 105445 775 29846239
Anger 20.11 10.55 7 105457 11113 29835901
Skin neoplasm excision 20.11 10.55 13 105451 302 29846712
Heart rate irregular 20.06 10.55 9 105455 12250 29834764
Epstein-Barr virus test positive 20.01 10.55 16 105448 523 29846491
Cancer surgery 19.98 10.55 15 105449 446 29846568
Pseudomonal sepsis 19.95 10.55 37 105427 2963 29844051
Debridement 19.94 10.55 21 105443 984 29846030
Sleep apnoea syndrome 19.89 10.55 18 105446 16839 29830175
Oxygen saturation decreased 19.86 10.55 82 105382 43358 29803656
Neurological symptom 19.85 10.55 40 105424 3407 29843607
Abdominal distension 19.84 10.55 88 105376 45621 29801393
Cutaneous mucormycosis 19.68 10.55 7 105457 38 29846976
Ischaemic stroke 19.66 10.55 17 105447 16258 29830756
Nephrosclerosis 19.65 10.55 19 105445 803 29846211
Dystonia 19.63 10.55 5 105459 9722 29837292
Alanine aminotransferase increased 19.61 10.55 369 105095 73907 29773107
Pityriasis rubra pilaris 19.55 10.55 8 105456 67 29846947
White blood cell count decreased 19.52 10.55 195 105269 83752 29763262
Papilloedema 19.50 10.55 32 105432 2324 29844690
Nephrolithiasis 19.46 10.55 36 105428 24774 29822240
Rhinocerebral mucormycosis 19.45 10.55 8 105456 68 29846946
Haematochezia 19.38 10.55 59 105405 34163 29812851
Evans syndrome 19.38 10.55 12 105452 258 29846756
Gastrointestinal haemorrhage 19.34 10.55 194 105270 83252 29763762
Pulmonary alveolar haemorrhage 19.32 10.55 59 105405 6522 29840492
Trichosporon infection 19.31 10.55 17 105447 636 29846378
Red blood cell abnormality 19.30 10.55 12 105452 260 29846754
Ventricular fibrillation 19.29 10.55 15 105449 15123 29831891
Therapy cessation 19.29 10.55 15 105449 15122 29831892
Acanthamoeba infection 19.25 10.55 15 105449 472 29846542
Oral herpes 19.18 10.55 46 105418 4409 29842605
Depressed mood 19.13 10.55 19 105445 17010 29830004
Respiratory tract infection fungal 19.09 10.55 17 105447 646 29846368
Infection reactivation 19.08 10.55 20 105444 932 29846082
Angioedema 18.97 10.55 60 105404 34324 29812690
Acanthosis 18.96 10.55 8 105456 73 29846941
Hepatic fibrosis 18.80 10.55 40 105424 3540 29843474
Heart rate decreased 18.75 10.55 28 105436 20966 29826048
Accidental overdose 18.74 10.55 22 105442 18253 29828761
Feeling cold 18.65 10.55 5 105459 9394 29837620
Arteriosclerosis coronary artery 18.61 10.55 8 105456 11168 29835846
Ureteral stent removal 18.61 10.55 4 105460 0 29847014
Undifferentiated sarcoma 18.61 10.55 4 105460 0 29847014
Meningococcal sepsis 18.54 10.55 6 105458 23 29846991
Fungal endocarditis 18.49 10.55 10 105454 165 29846849
Graft complication 18.47 10.55 13 105451 349 29846665
Lip swelling 18.41 10.55 11 105453 12733 29834281
Citrobacter infection 18.41 10.55 15 105449 504 29846510
Enterobacter infection 18.38 10.55 29 105435 2037 29844977
Adenomatous polyposis coli 18.38 10.55 10 105454 167 29846847
Disturbance in attention 18.36 10.55 31 105433 22098 29824916
Rib fracture 18.35 10.55 11 105453 12709 29834305
Infection 18.31 10.55 381 105083 77693 29769321
Organising pneumonia 18.31 10.55 49 105415 5025 29841989
Full blood count decreased 18.28 10.55 17 105447 15700 29831314
Atypical mycobacterial infection 18.24 10.55 18 105446 780 29846234
Pyelonephritis 18.19 10.55 51 105413 5375 29841639
Diffuse alveolar damage 18.16 10.55 28 105436 1928 29845086
Stent removal 18.15 10.55 5 105459 9 29847005
Blood pressure fluctuation 18.03 10.55 21 105443 17482 29829532
Haematemesis 18.02 10.55 41 105423 26162 29820852
Lung abscess 18.01 10.55 32 105432 2479 29844535
Sleep disorder 17.91 10.55 37 105427 24442 29822572
Skin toxicity 17.87 10.55 37 105427 3212 29843802
Pneumonia bacterial 17.84 10.55 73 105391 9330 29837684
Lactobacillus infection 17.81 10.55 8 105456 86 29846928
Sinus tachycardia 17.76 10.55 17 105447 15487 29831527
Reticulocytosis 17.76 10.55 12 105452 301 29846713
Hypercholesterolaemia 17.75 10.55 63 105401 7529 29839485
Tongue ulceration 17.74 10.55 21 105443 1121 29845893
Cardiac failure 17.68 10.55 198 105266 83220 29763794
Microangiopathic haemolytic anaemia 17.67 10.55 18 105446 811 29846203
Spindle cell sarcoma 17.65 10.55 8 105456 88 29846926
Hepatic enzyme increased 17.63 10.55 188 105276 33306 29813708
Restlessness 17.54 10.55 33 105431 22566 29824448
Hippocampal sclerosis 17.49 10.55 8 105456 90 29846924
Fungal abscess central nervous system 17.49 10.55 7 105457 55 29846959
Rash pruritic 17.48 10.55 33 105431 22539 29824475
Cytomegalovirus enterocolitis 17.47 10.55 18 105446 822 29846192
Ureteric dilatation 17.34 10.55 9 105455 136 29846878
Ageusia 17.32 10.55 5 105459 8948 29838066
Ureteral stent insertion 17.28 10.55 7 105457 57 29846957
Mycobacterium marinum infection 17.26 10.55 11 105453 249 29846765
Cough 17.24 10.55 325 105139 125317 29721697
Arthropathy 17.23 10.55 29 105435 20698 29826316
Biliary hamartoma 17.19 10.55 5 105459 12 29847002
Dry mouth 17.18 10.55 34 105430 22816 29824198
Rhinovirus infection 17.15 10.55 34 105430 2861 29844153
Neurological decompensation 17.12 10.55 30 105434 2298 29844716
Limb deformity 17.11 10.55 14 105450 473 29846541
Abscess drainage 17.11 10.55 11 105453 253 29846761
Epidermodysplasia verruciformis 17.11 10.55 6 105458 31 29846983
Palatal ulcer 17.11 10.55 6 105458 31 29846983
Disseminated toxoplasmosis 17.11 10.55 6 105458 31 29846983
Neutrophil count decreased 17.09 10.55 84 105380 42370 29804644
Bone marrow transplant 17.06 10.55 19 105445 949 29846065
Mitral valve incompetence 17.01 10.55 13 105451 13221 29833793
Pallor 16.99 10.55 30 105434 21019 29825995
Hepatitis viral 16.96 10.55 14 105450 479 29846535
Gastroenteritis norovirus 16.95 10.55 23 105441 1409 29845605
Hip fracture 16.94 10.55 9 105455 11115 29835899
Hot flush 16.93 10.55 16 105448 14664 29832350
Influenza like illness 16.86 10.55 41 105423 25564 29821450
Fungaemia 16.73 10.55 29 105435 2202 29844812
Gammopathy 16.67 10.55 7 105457 63 29846951
Thoracotomy 16.58 10.55 7 105457 64 29846950
Disorientation 16.51 10.55 56 105408 31362 29815652
Bile duct stenosis 16.47 10.55 21 105443 1210 29845804
Septic shock 16.45 10.55 315 105149 63292 29783722
Dysphonia 16.40 10.55 26 105438 19006 29828008
Hodgkin's disease mixed cellularity stage unspecified 16.38 10.55 4 105460 3 29847011
Cholangitis chronic 16.38 10.55 4 105460 3 29847011
Urethral dilatation 16.38 10.55 4 105460 3 29847011
Pseudallescheria infection 16.38 10.55 4 105460 3 29847011
Upper gastrointestinal haemorrhage 16.37 10.55 33 105431 21995 29825019
Aspartate aminotransferase increased 16.37 10.55 314 105150 63108 29783906
Colectomy 16.36 10.55 23 105441 1457 29845557
Urinoma 16.31 10.55 10 105454 211 29846803
Myasthenic syndrome 16.27 10.55 12 105452 347 29846667
Keratoacanthoma 16.24 10.55 14 105450 509 29846505
Surgery 16.18 10.55 82 105382 11469 29835545
Ureteritis 16.14 10.55 5 105459 16 29846998
Vascular graft complication 16.14 10.55 8 105456 109 29846905
Polyomavirus test positive 16.08 10.55 8 105456 110 29846904
Musculoskeletal chest pain 15.95 10.55 6 105458 9079 29837935
Glomerulonephropathy 15.95 10.55 8 105456 112 29846902
Hypophagia 15.94 10.55 34 105430 22202 29824812
Throat tightness 15.93 10.55 3 105461 7189 29839825
Plasmacytoma 15.92 10.55 36 105428 3320 29843694
Nephrostomy 15.91 10.55 10 105454 221 29846793
Osteoarthritis 15.88 10.55 25 105439 18324 29828690
Keratitis 15.86 10.55 20 105444 1140 29845874
Arteritis coronary 15.85 10.55 4 105460 4 29847010
Post procedural urine leak 15.80 10.55 9 105455 165 29846849
Keratitis bacterial 15.77 10.55 7 105457 73 29846941
Pathogen resistance 15.72 10.55 65 105399 8345 29838669
Lymphoma 15.72 10.55 74 105390 10047 29836967
Splenic abscess 15.70 10.55 11 105453 293 29846721
Cord blood transplant therapy 15.59 10.55 6 105458 42 29846972
Norovirus test positive 15.53 10.55 7 105457 76 29846938
Subcapsular renal haematoma 15.52 10.55 12 105452 373 29846641
Umbilical hernia repair 15.47 10.55 6 105458 43 29846971
Anaplastic large cell lymphoma T- and null-cell types 15.46 10.55 8 105456 120 29846894
Oral disorder 15.44 10.55 40 105424 4022 29842992
Dermatitis exfoliative generalised 15.42 10.55 32 105432 2783 29844231
Natural killer cell count increased 15.38 10.55 4 105460 5 29847009
Sporotrichosis 15.35 10.55 6 105458 44 29846970
Troponin increased 15.30 10.55 6 105458 8851 29838163
CSF pressure increased 15.29 10.55 5 105459 20 29846994
Urinary tract infection viral 15.29 10.55 5 105459 20 29846994
Superficial injury of eye 15.29 10.55 5 105459 20 29846994
Sinusitis bacterial 15.29 10.55 11 105453 306 29846708
Ureteric anastomosis complication 15.23 10.55 6 105458 45 29846969
Interleukin-2 receptor increased 15.23 10.55 8 105456 124 29846890
Epstein-Barr virus infection reactivation 15.18 10.55 10 105454 240 29846774
Hemianopia 15.18 10.55 15 105449 651 29846363
Diarrhoea haemorrhagic 15.17 10.55 50 105414 5755 29841259
Mental status changes 15.13 10.55 73 105391 37006 29810008
Ophthalmic herpes simplex 15.11 10.55 10 105454 242 29846772
Urinary tract infection enterococcal 15.10 10.55 17 105447 859 29846155
Salivary hypersecretion 15.06 10.55 4 105460 7562 29839452
Ureteral necrosis 15.01 10.55 6 105458 47 29846967
Disseminated varicella zoster vaccine virus infection 15.01 10.55 6 105458 47 29846967
Skin cancer metastatic 14.97 10.55 4 105460 6 29847008
Intra-aortic balloon placement 14.97 10.55 4 105460 6 29847008
Adult T-cell lymphoma/leukaemia recurrent 14.97 10.55 4 105460 6 29847008
Body height below normal 14.90 10.55 10 105454 248 29846766
Device malfunction 14.85 10.55 5 105459 8106 29838908
Peritonitis bacterial 14.85 10.55 11 105453 11367 29835647
Pneumonia klebsiella 14.85 10.55 30 105434 2560 29844454
Mycobacterium abscessus infection 14.83 10.55 14 105450 574 29846440
Infertility 14.80 10.55 9 105455 187 29846827
Necrosis 14.80 10.55 46 105418 5133 29841881
Viral myocarditis 14.73 10.55 8 105456 133 29846881
Ureteric obstruction 14.73 10.55 20 105444 1226 29845788
Nerve conduction studies abnormal 14.69 10.55 6 105458 50 29846964
Injection site reaction 14.57 10.55 10 105454 10750 29836264
Sudden death 14.49 10.55 20 105444 15472 29831542
Cryptosporidiosis infection 14.48 10.55 11 105453 333 29846681
Skin necrosis 14.46 10.55 43 105421 4684 29842330
Chest expansion decreased 14.42 10.55 8 105456 139 29846875
Extrapyramidal disorder 14.40 10.55 10 105454 10683 29836331
Liver abscess 14.39 10.55 34 105430 3228 29843786
Generalised oedema 14.35 10.55 81 105383 11804 29835210
Quadriparesis 14.31 10.55 18 105446 1023 29845991
Enterobacter bacteraemia 14.28 10.55 10 105454 266 29846748
Cutaneous sporotrichosis 14.24 10.55 4 105460 8 29847006
Autoinflammatory disease 14.23 10.55 5 105459 26 29846988
Hepatotoxicity 14.21 10.55 111 105353 18034 29828980
Retinal vasculitis 14.19 10.55 10 105454 269 29846745
Product container issue 14.13 10.55 16 105448 814 29846200
Explorative laparotomy 14.08 10.55 5 105459 27 29846987
Nasopharyngeal cancer 14.07 10.55 8 105456 146 29846868
Gastrointestinal candidiasis 14.07 10.55 8 105456 146 29846868
Product use issue 14.06 10.55 234 105230 45782 29801232
Granuloma 14.06 10.55 28 105436 2364 29844650
Malignant melanoma stage I 14.02 10.55 7 105457 97 29846917
Abdominal hernia repair 14.01 10.55 6 105458 57 29846957
Biliary catheter insertion 14.01 10.55 6 105458 57 29846957
Upper respiratory tract inflammation 14.00 10.55 24 105440 1807 29845207
Device issue 14.00 10.55 5 105459 7811 29839203
Liver operation 13.96 10.55 3 105461 0 29847014
Hepatitis B e antigen 13.96 10.55 3 105461 0 29847014
Leukopenia neonatal 13.96 10.55 3 105461 0 29847014
Peripheral artery dissection 13.96 10.55 3 105461 0 29847014
Renal cell carcinoma stage II 13.96 10.55 3 105461 0 29847014
Bence Jones protein urine present 13.96 10.55 3 105461 0 29847014
Growth disorder 13.96 10.55 3 105461 0 29847014
Transplant abscess 13.96 10.55 3 105461 0 29847014
Parenteral nutrition 13.96 10.55 3 105461 0 29847014
Tinea capitis 13.96 10.55 3 105461 0 29847014
Gingivectomy 13.96 10.55 3 105461 0 29847014
Ureteric repair 13.96 10.55 3 105461 0 29847014
Bacterial abdominal infection 13.96 10.55 3 105461 0 29847014
Tongue neoplasm 13.93 10.55 4 105460 9 29847005
Perinephric abscess 13.93 10.55 4 105460 9 29847005
Nephrogenic diabetes insipidus 13.88 10.55 19 105445 1174 29845840
Ventricular extrasystoles 13.84 10.55 12 105452 11462 29835552
Malabsorption 13.84 10.55 25 105439 1962 29845052
Eye discharge 13.82 10.55 23 105441 1690 29845324
Myocarditis toxoplasmal 13.78 10.55 5 105459 29 29846985
Cyanosis 13.78 10.55 13 105451 11922 29835092
Pollakiuria 13.73 10.55 24 105440 16882 29830132
Tuberculoma of central nervous system 13.69 10.55 10 105454 285 29846729
Viral uveitis 13.64 10.55 5 105459 30 29846984
Osteoma 13.64 10.55 5 105459 30 29846984
Bronchitis bacterial 13.63 10.55 15 105449 739 29846275
Coombs direct test positive 13.63 10.55 10 105454 287 29846727
Trichodysplasia spinulosa 13.59 10.55 9 105455 218 29846796
Creatinine urine increased 13.47 10.55 8 105456 159 29846855
Neck pain 13.43 10.55 34 105430 20910 29826104
Tooth hypoplasia 13.41 10.55 7 105457 107 29846907
Hypospermia 13.36 10.55 4 105460 11 29847003
Renal cell carcinoma stage III 13.36 10.55 4 105460 11 29847003
Stenotrophomonas infection 13.36 10.55 22 105442 1602 29845412
Neuroendocrine tumour of the lung metastatic 13.36 10.55 7 105457 108 29846906
Supraventricular tachycardia 13.32 10.55 10 105454 10262 29836752
Parvovirus B19 infection 13.30 10.55 13 105451 557 29846457
Intestinal obstruction 13.26 10.55 30 105434 19182 29827832
Liver transplant 13.23 10.55 30 105434 2772 29844242
Dry skin 13.23 10.55 38 105426 22416 29824598
Superficial spreading melanoma stage unspecified 13.17 10.55 8 105456 166 29846848
Renal infarct 13.16 10.55 18 105446 1111 29845903
Influenza 13.15 10.55 94 105370 43304 29803710
Arrhythmia 13.13 10.55 66 105398 33103 29813911
Enamel anomaly 13.13 10.55 7 105457 112 29846902
Eccrine squamous syringometaplasia 13.11 10.55 5 105459 34 29846980
Malignant neoplasm of renal pelvis 13.11 10.55 5 105459 34 29846980
Epstein-Barr virus antigen positive 13.11 10.55 5 105459 34 29846980
Complement factor C3 decreased 13.11 10.55 5 105459 34 29846980
Oral papilloma 13.11 10.55 4 105460 12 29847002
Blood count abnormal 13.09 10.55 13 105451 11639 29835375
Mania 13.09 10.55 8 105456 9146 29837868
Coronary artery occlusion 13.06 10.55 12 105452 11145 29835869
Dysarthria 13.05 10.55 59 105405 30431 29816583
Renal hypertension 13.04 10.55 8 105456 169 29846845
Product administration error 13.01 10.55 19 105445 14358 29832656
Skin hypertrophy 12.98 10.55 28 105436 2501 29844513
Malignant fibrous histiocytoma 12.97 10.55 7 105457 115 29846899
Urinary incontinence 12.91 10.55 25 105439 16915 29830099
Chronic kidney disease 12.91 10.55 196 105268 37642 29809372
Microangiopathy 12.90 10.55 15 105449 785 29846229
Computerised tomogram abnormal 12.90 10.55 23 105441 1786 29845228
Cold sweat 12.90 10.55 8 105456 9074 29837940
Papillary cystadenoma lymphomatosum 12.87 10.55 5 105459 36 29846978
Biliary ischaemia 12.87 10.55 4 105460 13 29847001
Splenic artery aneurysm 12.87 10.55 4 105460 13 29847001
Iron overload 12.83 10.55 19 105445 1262 29845752
Semen volume decreased 12.80 10.55 10 105454 316 29846698
Acquired gene mutation 12.77 10.55 18 105446 1143 29845871
Bone marrow oedema 12.73 10.55 12 105452 491 29846523
Sebaceous carcinoma 12.71 10.55 6 105458 73 29846941
Blood pressure systolic increased 12.69 10.55 21 105443 15089 29831925
Therapeutic procedure 12.68 10.55 8 105456 178 29846836
Hepatitis B surface antigen positive 12.65 10.55 7 105457 121 29846893
Device related sepsis 12.65 10.55 26 105438 2246 29844768
Renal artery stenosis 12.63 10.55 23 105441 1816 29845198
Herpes simplex test positive 12.60 10.55 8 105456 180 29846834
Melaena 12.59 10.55 65 105399 32372 29814642
Malacoplakia 12.50 10.55 7 105457 124 29846890
Pseudolymphoma 12.49 10.55 12 105452 503 29846511
Cytokine release syndrome 12.46 10.55 10 105454 9923 29837091
Pneumonia influenzal 12.46 10.55 19 105445 1296 29845718
Tracheitis 12.43 10.55 13 105451 604 29846410
Metastases to nasal sinuses 12.43 10.55 4 105460 15 29846999
T-cell lymphoma 12.43 10.55 16 105448 931 29846083
Metabolic acidosis 12.42 10.55 79 105385 37382 29809632
Prostate cancer 12.39 10.55 43 105421 23914 29823100
Meningitis viral 12.36 10.55 14 105450 712 29846302
Pneumonia respiratory syncytial viral 12.36 10.55 13 105451 608 29846406
Hyporeflexia 12.34 10.55 23 105441 1849 29845165
Karyotype analysis abnormal 12.31 10.55 5 105459 41 29846973
Chronic myeloid leukaemia recurrent 12.30 10.55 7 105457 128 29846886
Nervousness 12.30 10.55 14 105450 11774 29835240
Aneurysm 12.26 10.55 22 105442 1717 29845297
Peripheral T-cell lymphoma unspecified 12.26 10.55 12 105452 515 29846499
Ocular discomfort 12.24 10.55 19 105445 1316 29845698
Ophthalmic vein thrombosis 12.21 10.55 5 105459 42 29846972
VIth nerve paralysis 12.19 10.55 14 105450 723 29846291
Pericardial drainage 12.16 10.55 6 105458 81 29846933
Non-Hodgkin's lymphoma 12.15 10.55 22 105442 1729 29845285
Skin erosion 12.14 10.55 22 105442 1731 29845283
Gastroenteritis cryptosporidial 12.11 10.55 8 105456 193 29846821
Bordetella infection 12.11 10.55 5 105459 43 29846971
Haemorrhoids 12.04 10.55 15 105449 12126 29834888
Sebaceous adenoma 12.04 10.55 4 105460 17 29846997
Speech disorder 12.01 10.55 45 105419 24467 29822547
Lesion excision 12.01 10.55 5 105459 44 29846970
Anti-platelet antibody positive 12.01 10.55 9 105455 267 29846747
Metastases to lymph nodes 12.00 10.55 36 105428 3941 29843073
Chloroma 11.98 10.55 11 105453 435 29846579
Mediastinitis 11.97 10.55 12 105452 530 29846484
Tendonitis 11.93 10.55 58 105406 7978 29839036
Lung carcinoma cell type unspecified stage I 11.89 10.55 3 105461 3 29847011
Renal arteritis 11.89 10.55 3 105461 3 29847011
Hepatobiliary cancer 11.89 10.55 3 105461 3 29847011
Cyst drainage 11.89 10.55 3 105461 3 29847011
Transfusion associated graft versus host disease 11.89 10.55 3 105461 3 29847011
Macrophage activation 11.89 10.55 3 105461 3 29847011
Liver iron concentration increased 11.89 10.55 3 105461 3 29847011
Lung assist device therapy 11.86 10.55 4 105460 18 29846996
Muscle twitching 11.84 10.55 7 105457 8148 29838866
Tonsillar hypertrophy 11.83 10.55 12 105452 538 29846476
Lung neoplasm 11.74 10.55 39 105425 4507 29842507
Acarodermatitis 11.73 10.55 10 105454 358 29846656
Cytomegalovirus test 11.72 10.55 5 105459 47 29846967
Renal vein thrombosis 11.71 10.55 7 105457 141 29846873
Renal aneurysm 11.71 10.55 7 105457 141 29846873
Pseudomembranous colitis 11.69 10.55 29 105435 2839 29844175
Iris neoplasm 11.68 10.55 4 105460 19 29846995
Cytomegalovirus gastroenteritis 11.65 10.55 8 105456 206 29846808
T-cell prolymphocytic leukaemia 11.63 10.55 5 105459 48 29846966
Toxic skin eruption 11.58 10.55 13 105451 11002 29836012
Arterial rupture 11.57 10.55 11 105453 455 29846559
Meningitis tuberculous 11.56 10.55 12 105452 553 29846461
Acid fast bacilli infection 11.54 10.55 6 105458 91 29846923
Oedema peripheral 11.53 10.55 284 105180 105548 29741466
Throat irritation 11.50 10.55 8 105456 8540 29838474
Anaphylactic reaction 11.47 10.55 55 105409 27927 29819087
Incorrect dose administered 11.46 10.55 65 105399 31621 29815393
Peripheral nerve palsy 11.43 10.55 3 105461 4 29847010
Emotional distress 11.39 10.55 24 105440 15741 29831273
Bile duct stent insertion 11.37 10.55 6 105458 94 29846920
Pneumonia herpes viral 11.37 10.55 6 105458 94 29846920
Bone pain 11.36 10.55 32 105432 18994 29828020
Dermatitis acneiform 11.34 10.55 3 105461 5686 29841328
Ischaemic cardiomyopathy 11.32 10.55 4 105460 6293 29840721
Restless legs syndrome 11.31 10.55 5 105459 6867 29840147
Orchitis 11.31 10.55 20 105444 1543 29845471
Atelectasis 11.30 10.55 25 105439 16113 29830901
Lower respiratory tract infection 11.25 10.55 52 105412 26662 29820352
Tinnitus 11.20 10.55 25 105439 16063 29830951
Pupillary deformity 11.20 10.55 4 105460 22 29846992
Bronchioloalveolar carcinoma 11.20 10.55 4 105460 22 29846992
Low turnover osteopathy 11.20 10.55 6 105458 97 29846917
Renal cyst infection 11.19 10.55 5 105459 53 29846961
Thyroid cancer 11.17 10.55 18 105446 1287 29845727
Faeces discoloured 11.14 10.55 20 105444 13926 29833088
Oedema 11.14 10.55 213 105251 42780 29804234
Hepatic steatosis 11.13 10.55 22 105442 14771 29832243
B-lymphocyte count decreased 11.10 10.55 11 105453 479 29846535
Blood glucose decreased 11.09 10.55 18 105446 13035 29833979
Amnesia 11.06 10.55 46 105418 24275 29822739
Withdrawal syndrome 11.05 10.55 14 105450 11236 29835778
Chronic granulomatous disease 11.05 10.55 4 105460 23 29846991
Cerebrosclerosis 11.05 10.55 4 105460 23 29846991
Rectosigmoid cancer 11.04 10.55 7 105457 157 29846857
Anhedonia 11.04 10.55 8 105456 8361 29838653
Polychondritis 11.00 10.55 7 105457 158 29846856
Gynaecomastia 10.99 10.55 8 105456 8343 29838671
Blood immunoglobulin G decreased 10.98 10.55 15 105449 925 29846089
Sjogren's syndrome 10.95 10.55 5 105459 56 29846958
Dilatation intrahepatic duct acquired 10.95 10.55 5 105459 56 29846958
Sclerodactylia 10.91 10.55 4 105460 24 29846990
Retinal infiltrates 10.91 10.55 4 105460 24 29846990
Sinusitis fungal 10.90 10.55 10 105454 395 29846619
Myasthenia gravis 10.90 10.55 29 105435 2963 29844051
Idiopathic pneumonia syndrome 10.89 10.55 8 105456 230 29846784
Glomerular vascular disorder 10.88 10.55 5 105459 57 29846957
Psychotic disorder 10.87 10.55 39 105425 21476 29825538
Atrial septal defect 10.84 10.55 5 105459 6696 29840318
Poor quality sleep 10.82 10.55 6 105458 7235 29839779
Mucocutaneous leishmaniasis 10.80 10.55 5 105459 58 29846956
Prescribed underdose 10.79 10.55 7 105457 7752 29839262
Pneumocystis jirovecii infection 10.77 10.55 18 105446 1327 29845687
Tracheostomy 10.76 10.55 13 105451 709 29846305
Acute generalised exanthematous pustulosis 10.75 10.55 4 105460 6094 29840920
Electroencephalogram abnormal 10.75 10.55 25 105439 2349 29844665
Paranoia 10.73 10.55 12 105452 10176 29836838
Localised infection 10.71 10.55 20 105444 13717 29833297
Pulmonary cavitation 10.70 10.55 13 105451 713 29846301
H1N1 influenza 10.68 10.55 15 105449 949 29846065
Plasma cells increased 10.68 10.55 3 105461 6 29847008
Leiomyoma 10.68 10.55 3 105461 6 29847008
Nonkeratinising carcinoma of nasopharynx 10.68 10.55 3 105461 6 29847008
Cutaneous T-cell lymphoma stage I 10.68 10.55 3 105461 6 29847008
Diffuse mesangial sclerosis 10.68 10.55 3 105461 6 29847008
Diffuse large B-cell lymphoma stage I 10.68 10.55 3 105461 6 29847008
Cold agglutinins positive 10.68 10.55 3 105461 6 29847008
Complement factor increased 10.68 10.55 3 105461 6 29847008
Ureteric operation 10.68 10.55 3 105461 6 29847008
Torsade de pointes 10.68 10.55 6 105458 7184 29839830
Marrow hyperplasia 10.67 10.55 15 105449 950 29846064
Diverticulitis 10.67 10.55 29 105435 17416 29829598
Osteonecrosis 10.66 10.55 95 105369 16040 29830974
Haemolytic anaemia 10.65 10.55 66 105398 9944 29837070
Pulmonary hypertension 10.65 10.55 33 105431 19003 29828011
Cerebral aspergillosis 10.64 10.55 18 105446 1340 29845674
Nasal herpes 10.64 10.55 4 105460 26 29846988
Exophthalmos 10.57 10.55 11 105453 508 29846506

Pharmacologic Action:

SourceCodeDescription
ATC L04AD01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Calcineurin inhibitors
ATC S01XA18 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA EPC N0000175457 Calcineurin Inhibitor Immunosuppressant
FDA MoA N0000175458 Calcineurin Inhibitors
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:35705 immunosuppressant
CHEBI has role CHEBI:35718 antifungal drug
CHEBI has role CHEBI:35842 antirheumatic agent
CHEBI has role CHEBI:37153 protein serine/threonine phosphatase inhibitors
CHEBI has role CHEBI:49167 anti-asthmatic agents
CHEBI has role CHEBI:50177 dermatological agent
CHEBI has role CHEBI:50903 cancerogene
CHEBI has role CHEBI:149553 anti-coronaviral agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D065095 Calcineurin Inhibitors
MeSH PA D003879 Dermatologic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
FDA MoA N0000185503 P-Glycoprotein Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Tear film insufficiency indication 46152009
Rheumatoid arthritis indication 69896004 DOID:7148
Kawasaki's disease indication 75053002 DOID:13378
Keratoconjunctivitis sicca indication 302896008 DOID:12895
Prevention of Liver Transplant Rejection indication
Prevention of Cardiac Transplant Rejection indication
Prevention of Kidney Transplant Rejection indication
Severe Recalcitrant Psoriasis indication
Graft-versus-host disease off-label use 234646005
Pure Red Cell Aplasia associated with Chronic Lymphocytic Leukemia off-label use
Prevention of Lung Transplant Rejection off-label use
Prevention of Graft Versus Host Disease off-label use
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Hyperbilirubinemia contraindication 14783006 DOID:2741
Metabolic acidosis, normal anion gap, acidifying salts contraindication 18104000
Hyperuricemia contraindication 35885006 DOID:1920
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Benign intracranial hypertension contraindication 68267002 DOID:11459
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Disorder of brain contraindication 81308009 DOID:936
Kidney disease contraindication 90708001 DOID:557
Neoplasm contraindication 108369006
Malignant lymphoma contraindication 118600007 DOID:0060058
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Toxic nephropathy contraindication 236514003
Hypertriglyceridemia contraindication 302870006
Primary malignant neoplasm contraindication 372087000
Breastfeeding (mother) contraindication 413712001
Hypertensive urgency contraindication 443482000
BK Polyomavirus Reactivation Nephropathy contraindication
Cyclosporine Toxicity contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Peptidyl-prolyl cis-trans isomerase A Enzyme MODULATOR IC50 8.05 WOMBAT-PK CHEMBL
Dihydroorotate dehydrogenase (quinone), mitochondrial Enzyme IC50 6.70 WOMBAT-PK
Peptidyl-prolyl cis-trans isomerase FKBP1A Enzyme IC50 7.80 WOMBAT-PK
Substance-K receptor GPCR Ki 5.86 DRUG MATRIX
Multidrug resistance protein 1 Transporter EC50 6.30 WOMBAT-PK
Cytochrome P450 3A4 Enzyme Ki 5.31 WOMBAT-PK
Sodium/bile acid cotransporter Transporter INHIBITOR IC50 6 IUPHAR
Solute carrier organic anion transporter family member 1B3 Transporter INHIBITOR IC50 6.10 IUPHAR
fMet-Leu-Phe receptor GPCR ANTAGONIST EC50 6.30 IUPHAR
Canalicular multispecific organic anion transporter 1 Transporter IC50 4.87 CHEMBL
Multidrug resistance-associated protein 1 Transporter IC50 5.57 CHEMBL
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Enzyme Kd 8.40 CHEMBL
Peptidyl-prolyl cis-trans isomerase D Enzyme Ki 8.15 CHEMBL
Peptidyl-prolyl cis-trans isomerase B Enzyme Kd 8.01 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP1B Enzyme Ki 8.22 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP4 Enzyme IC50 7.80 CHEMBL
ATP-binding cassette sub-family G member 2 Transporter IC50 4.20 CHEMBL
Bile salt export pump Transporter IC50 6.30 CHEMBL
Solute carrier organic anion transporter family member 1B1 Transporter INHIBITOR Ki 7.29 IUPHAR
Reverse transcriptase/RNaseH Enzyme IC50 6.34 CHEMBL
Bile salt export pump Unclassified IC50 6.22 CHEMBL

External reference:

IDSource
4018761 VUID
N0000147064 NUI
D00184 KEGG_DRUG
4018761 VANDF
C0010592 UMLSCUI
CHEBI:4031 CHEBI
CHEMBL160 ChEMBL_ID
DB00091 DRUGBANK_ID
D016572 MESH_DESCRIPTOR_UI
5284373 PUBCHEM_CID
1024 IUPHAR_LIGAND_ID
5086 INN_ID
83HN0GTJ6D UNII
202817 RXNORM
3027 MMSL
31626 MMSL
4521 MMSL
72396 MMSL
d00079 MMSL
003420 NDDF
387467008 SNOMEDCT_US
80906007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Restasis MultiDose HUMAN PRESCRIPTION DRUG LABEL 1 0023-5301 EMULSION 0.50 mg OPHTHALMIC NDA 23 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 0023-9163 EMULSION 0.50 mg OPHTHALMIC NDA 24 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-0541 CAPSULE 50 mg ORAL ANDA 24 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-3108 CAPSULE 25 mg ORAL ANDA 24 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-3109 CAPSULE 100 mg ORAL ANDA 24 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-6463 CAPSULE 25 mg ORAL ANDA 24 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-6479 CAPSULE 100 mg ORAL ANDA 24 sections
Gengraf HUMAN PRESCRIPTION DRUG LABEL 1 0074-7269 SOLUTION 100 mg ORAL ANDA 24 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0109 INJECTION 50 mg INTRAVENOUS NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0110 SOLUTION 100 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0240 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 23 sections
Sandimmune HUMAN PRESCRIPTION DRUG LABEL 1 0078-0241 CAPSULE, LIQUID FILLED 100 mg ORAL NDA 23 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0246 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 23 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0248 CAPSULE, LIQUID FILLED 100 mg ORAL NDA 23 sections
Neoral HUMAN PRESCRIPTION DRUG LABEL 1 0078-0274 SOLUTION 100 mg ORAL NDA 23 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-5740 CAPSULE, LIQUID FILLED 25 mg ORAL ANDA 16 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-5741 CAPSULE, LIQUID FILLED 50 mg ORAL ANDA 16 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-5742 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 16 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-9018 CAPSULE, LIQUID FILLED 25 mg ORAL ANDA 16 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-9019 CAPSULE, LIQUID FILLED 50 mg ORAL ANDA 16 sections
CyclosporineModified HUMAN PRESCRIPTION DRUG LABEL 1 0093-9020 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 16 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 0172-7313 SOLUTION 100 mg ORAL ANDA 23 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 0574-0866 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 22 sections
CEQUA HUMAN PRESCRIPTION DRUG LABEL 1 47335-506 SOLUTION/ DROPS 0.00 g OPHTHALMIC NDA 22 sections
CEQUA HUMAN PRESCRIPTION DRUG LABEL 1 47335-507 SOLUTION/ DROPS 0.00 mg OPHTHALMIC NDA 22 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 50090-1242 EMULSION 0.50 mg OPHTHALMIC NDA 24 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 50090-4476 EMULSION 0.50 mg OPHTHALMIC NDA 25 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 51862-458 CAPSULE, LIQUID FILLED 25 mg ORAL ANDA 26 sections
Cyclosporine HUMAN PRESCRIPTION DRUG LABEL 1 51862-460 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 26 sections
RESTASIS HUMAN PRESCRIPTION DRUG LABEL 1 54868-4793 EMULSION 0.50 mg OPHTHALMIC NDA 22 sections